METHOD OF DIAGNOSIS

The invention relates to a method of diagnosing a scar of interest as keloid or non-keloid. The invention also provides kits and oligonucleotide arrays suitable for use in the diagnosis of a scar of interest as keloid or non-keloid.

Keloids (also referred to as keloid scars) are pathological scars produced by an aberrant and over-exuberant wound healing response. Keloids comprise raised scars that spread beyond the margins of an original wound and invade the normal skin surrounding the wound site. Keloids continue to grow over time, and do not regress spontaneously.

Keloids occur with equal frequency in men and women. The incidence of keloid formation is increased in those aged between 10 and 30 years. Keloids may arise as a result of a wide range of injuries, including piercing, surgery, vaccination, tattoos, bites, blunt trauma and burns.

Keloids may have a “domed”, nodular or ridged appearance. Keloids may have a colour similar to that of the surrounding unwounded skin, but are frequently somewhat darker, with a red, purple or brown appearance. Such colour mismatches may increase the visual prominence of keloids. The tendency for hyperpigmentation in keloids is increased on their exposure to solar ultraviolet radiation.

A keloid lesion may be considered to be made up of a number of different portions that may each exhibit quite different biological activity from one another. The central part of a mature keloid lesion (the intra-lesional portion) is largely acellular, while the peripheral part of the lesion (the peri-lesional portion) is relatively more cellular and is the site of increased angiogenic activity. This increase in new blood vessel formation has been linked with the outward growth of the lesion.

Although they represent examples of pathological scarring, keloids are primarily composed of the same cell types and extracellular matrix components that are found in undamaged skin and normal dermal scars. However, the relative abundance and arrangement of these cell types and extracellular matrix components differ from those found in either unwounded skin or normal dermal scars.

The major constituent of keloids is the extracellular matrix component collagen I. Fibroblasts derived from keloids exhibit up to a twenty-fold higher expression of collagen I in vitro, as compared to normal dermal fibroblasts. Similarly, cultured keloid fibroblasts also express elevated levels of elastin and proteoglycans, and it is believed that this increase in extracellular matrix deposition may play a role in keloid development and maintenance.

Collagen I present in keloids is arranged primarily in the form of thick “whorls”, which may be differentiated from the arrangement found in unwounded skin (a so-called “basket weave” of fibrils) and in normal scars (which contain collagen fibres that are thinner than those found in keloids and are arranged approximately parallel to one another). The frequent presence of thickened hyalinized collagen within keloids has led to this form of collagen being termed “keloidal collagen”.

Keloids contain fewer macrophages than do normal scars, but contain abundant eosinophils, mast cells, plasma cells and lymphocytes.

Keloids are seldom a direct cause of pain, but may give rise to discomfort, tenderness, irritation or itching during their formation or growth. Keloids may also impair mechanical function through their size or their increased stiffness compared to unwounded skin. This impairment may be particularly noticeable in the case of keloids located near a joint. Furthermore, it is well recognised that keloids, and in particular large or noticeably disfiguring examples, can cause psychological distress to those afflicted.

A further highly damaging property of keloids is their propensity to recur, particularly following surgical excision. Recurrence of keloids under such circumstances is normally also associated with further expansion of the lesion, and keloids may expand more aggressively following an earlier excision.

Treatment options for hypertrophic scars are similar to those for keloids with the exception that surgical excision is an acceptable and often more favourable approach.

It will, be appreciated that in the case of keloids, it will generally be preferred to avoid surgical intervention when possible. Given their high incidence of recurrence, and the fact that such recurrence is exacerbated by surgical intervention, it is important to be able to accurately diagnose keloids in order that suitable treatment regimes may be employed. Current treatment regimes for keloids include corticosteroid injections, cryotherapy, radiation therapy, silicone gel dressings and intra-lesional injection of agents intended to reduce the size of keloid scarring.

In present practice diagnosis of keloids is undertaken on the basis of the appearance of the scar. However, the accurate diagnosis of keloids is hampered by the fact that keloid morphology may be very similar to that of other pathological scars. The appearance of keloids and hypertrophic scars may be particularly similar. Hypertrophic scars resemble keloid scars in that they are also raised above the skin level. However, hypertrophic scars differ from keloids in that they remain within the boundaries of the original lesion, and may regress spontaneously several months after the initial injury. The visual similarity between keloid and hypertrophic scars means that diagnosis of a raised scar between these two distinct conditions is often confusing and cannot be accurately undertaken without long-term monitoring. There is a need for rapid and accurate means by which scars of interest may be diagnosed to indicate whether they are keloid in nature, or whether they belong to other pathological or excessive scarring types, such as hypertrophic scars.

Raised scars may often be assumed to be associated with keloid disease, and in the case of black patients an elevated scar will often be diagnosed by default as keloidal by many physicians (Rosenborough et al, 2004. J. Natl. Med. Assoc. 96, 108). This tendency can lead to the mis-identification of non-keloids scars (such as hypertrophic scars or very bad non-pathological scars) as keloids. It will be appreciated that this potential mis-diagnosis can result in inappropriate scar management decisions and can block the use of elective/scar revision surgery as a viable therapeutic approach in the case of such mis-diagnosed scars.

It is known that keloids are the only pathological dermal scars that grow beyond the boundaries of the original injury, as noted above. This property can provide a basis on which differential diagnosis between keloid and hypertrophic scars may be undertaken, although such diagnosis requires a very long time, given the need for prolonged observation of the scar to be diagnosed.

Other attempts to provide a basis on which tissues may be diagnosed as keloid or non-keloid have utilised histological assessments. Among the histological features suggested as providing suitable basis for diagnosis of keloids is the presence of so called “keloidal collagen”, a thickened hyalinized form of collagen, although this is not found in all keloid samples. Further features that may allow for the differentiation of keloids from other pathological scars (such as hypertrophic scars) are the presence of a non-flattened epidermis in keloids, non-fibrotic papillary dermis, the presence of a “tongue-like” advancing edge that surrounds keloid lesions (located below the normal-appearing epidermis and papillary dermis), presence of a horizontal cellular fibrous band located in the upper reticular dermis, and the presence of a prominent fascia-like band.

However, these histological cues for the diagnosis of keloids are also unsatisfactory. Not all of the features suggested as diagnostic markers are found in all keloid tissues, and similarly some of the suggested markers may also be found in non-keloid tissues.

Furthermore, the use of histological means for diagnosis of keloids requires considerable time to be expended in the preparation and analysis of histological samples, as well as the need for the application of skill and judgement on the part of the person undertaking such analysis.

Rapid and accurate methods and kits for the diagnosis of keloid scars will enable diagnosis to be undertaken with greater confidence. This will facilitate taking of correct decisions regarding the clinical treatment of skin lesions, and will be advantageous in treatment of both keloid and non-keloid lesions. In the case of tissues diagnosed as keloids it will be possible to avoid treatments that may otherwise exacerbate keloid recurrence and expansion, while such considerations will not be inappropriately applied in the treatment of non-keloid tissues. Furthermore, it is likely that early accurate diagnosis may have major benefits in relation to the success of palliative care regimes treatments, since many available treatments are believed to be more effective on less-mature scars.

The ability to differentiate between keloid-forming and non-keloid-forming patients may thus provide great advantages in terms of limiting surgery, and hence the risk of keloid formation, amongst those prone to keloid development, since it is generally considered that the prevention of keloid formation is of paramount importance in the management of keloid-forming patients, and avoidance of non-essential cosmetic surgery is recommended for these individuals.

In the light of the above it will be appreciated that there exists a well recognised need for the provision of new and alternative methods and kits for the diagnosis of keloids. Such methods and kits may preferably be suited to the safe and reliable diagnosis of keloids.

It is an aim of certain embodiments of the invention to provide novel methods and markers for the diagnosis of keloids. It is another aim of certain embodiments of the present invention to provide methods of diagnosis that allow a greater degree of certainty in diagnosis of a scar of interest as keloid or non-keloid than may be achieved by the prior art. It is another aim of certain embodiments of the invention to provide methods of diagnosis that allow greater speed of diagnosis, to determine whether a scar of interest is keloid or non-keloid, than do the methods of the prior art. It is still another aim of certain embodiments of the invention to provide methods for the diagnosis of a scar of interest as keloid or non-keloid that do not require the taking of large biopsies in order for a diagnosis to be made. It is still another aim of certain embodiments of the invention to provide methods, allowing the diagnosis of a scar of interest as keloid or non-keloid, that do not involve procedures that are likely to cause the recurrence and/or exacerbation of keloid formation.

According to a first aspect of the present invention there is provided a method for diagnosing a scar of interest as keloid or non-keloid, the method comprising:

comparing expression in a sample representative of gene expression in the scar of interest of at least one gene, selected from the group of genes set out in Table 1, with expression of the said at least one gene in a comparator tissue;

wherein decreased expression of said at least one gene in the scar of interest compared to expression of said at least one gene in the comparator tissue indicates that the scar of interest comprises a keloid.

In a second aspect of the invention there is provided a kit for diagnosing a scar of interest as keloid or non-keloid, the kit comprising:

i) at least one probe capable of binding specifically to a target molecule representative of expression in the scar of interest of at least one gene selected from the group set out in Table 1; and

ii) reference material able to indicate the level of expression of said at least one gene in comparator tissue.

It is preferred that the methods and kits of the invention to be used for in vitro diagnosis of a scar of interest as keloid or non-keloid.

Although the methods and kits of the invention are most suitable for use in diagnosis of human scars as keloid or non-keloid, they may also be useful in diagnosing similar conditions in non-human animals, such as “proud flesh” in horses.

The present invention is based on the identification by the inventors of a number of genes the decreased expression of which is diagnostic of keloid tissue. The inventors have found that comparison of the expression of one or more of these genes in a scar of interest with the expression occurring in a comparator tissue allows an accurate and rapid diagnosis as to whether the tissue is keloid or non-keloid. Identity of the scar of interest as keloid is indicated by a decrease in gene expression as compared to expression in the comparator tissue sample, whereas unchanged or increased expression in the scar of interest as compared to the comparator indicates that the scar of interest is non-keloid tissue.

The finding that decreased expression of the genes identified in Table 1 (i.e. the group comprising Gene Identification No. 1 to Gene Identification No. 590) may be used to diagnose whether a scar of interest is keloid or non-keloid is surprising, since although the expression of certain genes (such as those encoding VEGF, IGF1 and PAI1) has been linked to keloid tissue, the genes set out in Table 1 had never previously been identified as being associated with keloids, let alone as diagnostic of keloid scars.

In practicing the invention (whether by use of the methods, kits or arrays of the invention), expression of a selected gene (or genes) in a sample representative of gene expression in the scar of interest is compared with expression of the same gene (or genes) in a suitable comparator tissue. This comparison of expression of the selected gene (or genes) enables diagnosis of the scar of interest as keloid or non-keloid. If there is decreased expression of the selected gene (or genes) in the sample representative of gene expression in the scar of interest, as compared to in the comparator sample, then this indicates that the scar of interest comprises keloid tissue. If, on the other hand, there is no decrease in expression of the selected gene (or genes) in the sample representative of expression in the scar of interest (or, indeed, if there is an increase in expression of these genes), this indicates that the scar of interest does not comprise keloid tissue.

In general expression of selected genes in the scar of interest will be investigated by analysis of target molecules representative of gene expression. Suitable investigation may involve the analysis for presence or absence of such target molecules in a sample (qualitative analysis of gene expression, as discussed further elsewhere in the specification), or analysis of the relative abundance of target molecules in a sample (which may provide quantitative information as to gene expression, as considered in more detail elsewhere in the specification).

Gene expression in the comparator tissue may be represented by tissues or tissue extracts containing suitable target molecules, or may alternatively be represented by data setting out details of the gene expression levels in the comparator. The identification, isolation and analysis of suitable target molecules is discussed further elsewhere in the specification, as is the provision of information representative of gene expression in comparator tissue samples.

A comparator tissue, for the purposes of the present disclosure, is a tissue with which gene expression in a scar of interest can be compared, in order to allow diagnosis of the scar of interest as keloid or non-keloid. Specifically, the expression in the scar of interest of at least one gene set out in Table 1 is compared with expression of the same gene (or genes) in the comparator tissue.

A number of different tissue types may serve as suitable comparator tissues for use in accordance with the present invention. Suitable comparator tissues include normal skin. For the present purposes normal skin may be considered to be skin other than in a keloid scar, and preferably to be unscarred and unwounded skin.

Alternatively a comparator tissue suitable for use in accordance with the present invention may be tissue from a known keloid. For instance a suitable comparator tissue for use in accordance with the invention may comprise tissue from the skin adjacent to a known keloid (also referred to in the present specification as “extra-keloid comparator tissue”). Alternatively, a suitable comparator tissue may comprise tissue from the area at the periphery of a known keloid (also referred to herein as “peri-keloid comparator tissue”). In a further alternative, a suitable comparator tissue may comprise tissue from the interior part of a known keloid (also referred to as “intra-keloid comparator tissue”).

A “comparator sample” for the purposes of the present invention comprises any sample (such as a tissue extract, or the like, as considered elsewhere in the specification) that provides information as to the expression of a selected gene in the comparator tissue from which the comparator sample is derived.

Although the inventors have found that any of the genes represented by the group of genes set out in Table 1 may be used in accordance with the present invention, the inventors have further found that certain subsets of these genes have particular diagnostic value. These subsets are identified and considered in more detail below.

The inventors have noted that expression of certain genes set out in Table 1 varies between different areas of a keloid lesion. This information may be used to further refine diagnosis in accordance with the present invention (whether by methods, kits, or arrays of the invention).

The inventors have also found that preferred genes that may be investigated in the methods and kits of the invention may be selected with reference to their biological function.

A sample of interest, representative of a scar of interest to be diagnosed, may be further characterised with reference to the location from which it is derived in the scar. The inventors have found that characterisation of a sample of interest on this basis improves the efficacy of diagnoses undertaken in accordance with the invention. Samples of interest may be characterised as peri-lesional (which is to say samples taken from the periphery of a lesion comprising a scar of interest) and intra-lesional (those samples taken from the interior of a lesion comprising a scar of interest).

Genes from Table 1 that may be used in the diagnosis of peri-lesional samples of interest are set out in Table 2. It is a preferred embodiment that diagnosis in accordance with the invention (whether using the methods, kits or arrays of the invention) may be performed on the basis of comparison of one or more of the genes set out in Table 2.

Genes from Table 1 that may be used in the diagnosis of intra-lesional samples of interest are set out in Table 20. It is a preferred embodiment that diagnosis in accordance with the invention (whether using the methods, kits or arrays of the invention) may be performed on the basis of comparison of one or more of the genes set out in Table 20.

As set out above, comparator tissues suitable for use in diagnosis in accordance with the invention may also be characterised with reference to their source, as normal skin comparators; extra-keloid comparators; peri-keloid comparators; or intra-keloid comparators. The inventors have found that diagnosis in accordance with the invention may be improved by comparison of gene expression in a sample of interest characterised with reference to their location in a scar of interest, with gene expression of a comparator characterised in the manner set out above.

Thus it may be preferred that gene expression in a peri-lesional sample of interest is compared with gene expression in a normal skin comparator. Examples of suitable genes, expression of which may be compared between such samples in order to provide a diagnosis, are set out in Table 3. These genes may be further characterised with reference to their biological function. Accordingly those genes set out in Table 4 represent genes associated with cell motility, whereas those set out in Table 5 are associated with cell adhesion, the genes set out in Table 6 are associated with inflammation, and the genes set out in Table 7 are associated with the development of new blood vessels (particularly with angiogenesis).

Alternatively or additionally, it may be preferred that gene expression in a peri-lesional sample of interest is compared with gene expression in an extra-keloid comparator. Examples of suitable genes, expression of which may be compared between such samples in order to provide a diagnosis, are set out in Table 8. These genes may be further characterised with reference to their biological function. Accordingly those genes set out in Table 9 represent genes associated with cell motility, whereas those set out in Table 10 are associated with cell adhesion, the genes set out in Table 11 are associated with inflammation, and the genes set out in Table 12 are associated with the development of new blood vessels (particularly with angiogenesis).

Alternatively or additionally, it may be preferred that gene expression in a peri-lesional sample of interest is compared with gene expression in a peri-keloid comparator. Examples of suitable genes, expression of which may be compared between such samples in order to provide a diagnosis, are set out in Table 13. It will be appreciated that diagnosis on the basis of such comparisons will involve the gene expression in a tissue of interest and a comparator that are at different time-points in the healing process. Information regarding the time-points to be used is provided in Table 13. The genes set out in Table 13 may also be further characterised with reference to their biological function. Accordingly those genes set out in Table 14 are associated with cell adhesion, the genes set out in Table 15 are associated with inflammation, and the genes set out in Table 16 are associated with the development of new blood vessels (particularly with angiogenesis).

Alternatively or additionally, it may be preferred that gene expression in a peri-lesional sample of interest is compared with gene expression in an intra-keloid comparator. Examples of suitable genes, expression of which may be compared between such samples in order to provide a diagnosis, are set out in Table 17. These genes may be further characterised with reference to their biological function. Accordingly those genes set out in Table 18 represent genes associated with cell motility, whereas those set out in Table 19 are associated with inflammation.

Alternatively or additionally, it may be preferred that gene expression in an intra-lesional sample of interest is compared with gene expression in a normal skin comparator. Examples of suitable genes, expression of which may be compared between such samples in order to provide a diagnosis, are set out in Table 21.

Alternatively or additionally, it may be preferred that gene expression in an intra-lesional sample of interest is compared with gene expression in an extra-keloid comparator. Examples of suitable genes, expression of which may be compared between such samples in order to provide a diagnosis, are set out in Table 22. These genes may be further characterised with reference to their biological function. Accordingly those genes set out in Table 23 represent genes associated with cell motility.

Alternatively or additionally, it may be preferred that gene expression in an intra-lesional sample of interest is compared with gene expression in a peri-keloid comparator. Examples of suitable genes, expression of which may be compared between such samples in order to provide a diagnosis, are set out in Table 24. These genes may be further characterised with reference to their biological function. Accordingly those genes set out in Table 25 are associated with cell adhesion.

Alternatively or additionally, it may be preferred that gene expression in an intra-lesional sample of interest is compared with gene expression in an intra-keloid comparator. Examples of suitable genes, expression of which may be compared between such samples in order to provide a diagnosis, are set out in Table 26. It will be appreciated that diagnosis on the basis of such comparisons will involve the gene expression in a tissue of interest and a comparator that are at different time-points in the healing process. Information regarding the time-points to be used is provided in Table 26. The genes set out in Table 26 may also be further characterised with reference to their biological function. Accordingly those genes set out in Table 27 are associated with inflammation, and the genes set out in Table 28 are associated with the development of new blood vessels (particularly with angiogenesis).

It may be preferred that diagnosis in accordance with the present invention, whether carried out using the methods, kits or arrays of the invention, utilise comparison of one or more gene selected independently from one or more of the Tables 2 to 28.

A skilled person wishing to undertake a diagnosis in accordance with the invention may consider the nature of a sample that is available from a scar of interest, consider the nature of a comparator sample that is available, and thereby select appropriate genes expression of which may be compared with reference to the considerations set out above.

It is particularly preferred that the methods, kits or arrays of the invention may involve the comparison of genes selected from two or more of Tables 2 to 28. For example, preferred methods, kits or arrays may involve the comparison of at least one gene selected from each of two of Tables 2 to 28, more preferred methods, kits or arrays may involve comparison of at least one gene selected from each of three of Tables 2 to 28, even more preferred methods, kits or arrays may involve comparison of at least one gene selected from each of four of Tables 2 to 28, and most preferred methods, kits or arrays may involve comparison of at least one gene selected from each of five or more of Tables 2 to 28.

Diagnosis of a scar of interest as keloid or non-keloid in accordance with the present invention may be effected by comparing the expression in a sample representative of gene expression in the scar of interest with expression in a comparator sample of one gene selected from Table 1, however, it is preferred to utilise multiple genes from Table 1. Thus it may be preferred that diagnosis in accordance with the present invention may be effected by comparing the expression of up to five genes selected from Table 1. It is particularly preferred that diagnosis in accordance with the present invention is effected by comparing the expression of 5, 6, 7, 8, 9 or 10 genes selected from Table 1. Diagnosis may be effected by comparing expression of up to 20 or 50 genes selected from Table 1. Diagnosis in accordance with the present invention may be effected by comparing the expression of up to 100, 200, 300, 400 or even up to 500, genes selected from Table 1. Indeed it may in certain cases be preferred that diagnosis of a scar of interest as keloid or non-keloid in accordance with the present invention is effected by comparing the expression of 500 or more genes selected from Table 1. If so desired, a diagnosis can be made using any or all of the 590 genes represented in Table 1.

A scar of interest in the context of the present invention may be any scar for which it is desired to diagnose whether the scar comprises keloid or non-keloid tissue. It will be appreciated that dermal scars constitute preferred examples of suitable scars of interest. The ability to distinguish between keloids and other forms of severe or pathological scarring, such as hypertrophic scars, is of notable value. Such differentiation may allow the selection of clinical treatment that is appropriate to the type of scarring diagnosed. Accordingly, the use of the methods and kits of the present invention in effecting diagnosis of excessive or pathological dermal scars represents a particularly preferred example of their use.

A scar of interest may preferably be derived from an individual believed to be at elevated risk of keloid formation. Examples of such individuals include patients with a history of keloid formation, individuals of the African Continental Ancestry Group or individuals of the Asian Continental Ancestry Group.

Suitable scars of interest may be derived from individuals who have suffered injury to the skin. In particular these may include individuals suffering injury at a site where there is an elevated risk of keloid formation. Examples of such sites may typically include areas of high skin tension, such as the chest, back, shoulders, or neck. However, relevant sites may also include areas, such as the earlobes, that are common sites of keloid formation, although not subject to high skin tension.

Diagnosis using the methods, kits, and arrays of the invention may be useful in diagnosing scars of interest from patients who have experienced skin wounding, as well as in diagnosing scars of interest from patients who have experienced skin trauma.

For the purposes of the present invention “skin wounding” may be considered to comprise conditions or clinical situations in which partial or total penetration of the skin occurs, and also those in which partial or total destruction of one or more layers of the skin occurs. For example, wounds may include puncture wounds, incisional wounds, excisional wounds and partial or full thickness skin grafts (including both donor and recipient sites). Such wounds may be associated with surgical procedures or accidental injuries. Wounds may also include burn or scald injuries, resulting from exposure of the skin to substances at high or low temperatures sufficient to cause damage to the skin. Chemical “burns”, such as those caused by exposure of the skin to acid or alkali, and cosmetic procedures such as dermabrasion or exfoliation (included so-called “chemical peels” and “laser peels”) may also give rise to tissues for which it is wished to produce a diagnosis in accordance with the present invention.

For the purposes of the present invention “skin trauma” may be taken as referring to injuries that damage, but do not penetrate, the skin. Illustrative examples of injuries that may be considered as skin trauma include crush injuries to the skin, as well other “blunt” injuries.

Although the preceding paragraphs provide examples of individuals, or of scars of interest, that may particularly benefit from diagnosis in accordance with the present invention it will be appreciated that the methods, kits and arrays of the invention may be beneficially used in diagnosis of any scar of interest, particularly those that may be believed to be keloid scars. Generally tissues that are believed possibly to be keloid scars will be those that display one or more characteristics selected from the following group: an elevated profile compared to the surrounding skin; a lesion growing beyond its original boundaries; a lesion at the site of an earlier skin wound or trauma; hypo- or hyper-pigmentation compared to the surrounding skin.

Samples representative of gene expression in a scar of interest that may be used in accordance with the present invention encompass any sample that may provide information as to genes being expressed by the scar of interest.

Any suitable sample derived from the scar of interest may be used. Preferred sample include biopsies and, if available, samples of wound tissue, wound fluid, wound aspirates or wound exudates. Preferably such biopsies may be of a sort selected to reduce the level of injury inflicted to the patient, and thereby limit damage to those found to reduce the risk of (further) keloid formation. Such techniques may, for example, make use of needle biopsies in order to reduce the level of injury occurring. Any of the sample types discussed above may be used in diagnosis, in accordance with the invention, of the scar of interest from which the sample in question is derived.

Suitable samples may include tissue sections such as histological or frozen sections. Methods by which such sections may be prepared in such a way as to be able to provide information representative of gene expression in the scar of interest from which the section is derived will be well known to those skilled in the art, and should be selected with reference to the technique that it is intended to use when investigating gene expression.

Although the use of samples comprising a portion of the scar of interest is contemplated, it may generally be preferred that the sample representative of gene expression comprise a suitable extract taken from the scar of interest, said extract being capable of investigation to provide information regarding gene expression in the scar of interest. Suitable protocols which may be used for the production of tissue extracts capable of providing information regarding gene expression in a scar of interest will be well known to those skilled in the art. Preferred protocols may be selected with reference to the manner in which gene expression is to be investigated. Illustrative examples of protocols that may be used to produce tissue extracts representative of gene expression in a scar of interest are discussed below.

Suitable comparator samples, for use in accordance with methods, kits or arrays of the invention, may be selected with reference to the scar of interest in respect of which diagnosis is to be performed. Preferably the comparator tissue will be as well matched as possible to the scar of interest (matching may consider tissue type, tissue site, etc.). Sources and examples of suitable comparator samples will be apparent to those skilled in the art and include those derived from individuals that are not subject to keloid formation, as well as samples from keloid formers selected with reference to their location relative to a known keloid (i.e. non-keloid tissue, extra-keloid tissue, peri-lesional tissue, or intra-lesional tissue). It will be recognised that the skin constitutes a preferred source of comparator samples.

Suitable comparator samples may include portions of non-keloid tissues or organs including target molecules representative of gene expression (in which case the tissue should be preserved in such a manner that information regarding the expression of genes in the tissue may be extracted from the tissue, for example by analysis of the target molecules). Alternatively, suitable comparator samples may comprise tissue extracts incorporating extracted and/or isolated target molecules (such as mRNA or cDNA) that are representative of gene expression in the comparator sample. Relevant information regarding gene expression in comparator samples may also be provided in the form of data derived from such samples, as considered elsewhere in the specification.

Comparator samples from which information relating to the expression of selected genes may be derived include tissue samples and tissue extracts as considered herein with reference to samples derived from the scar of interest. For example, such information may be derived directly from a tissue or organ sample constituting the comparator sample, or from an extract capable of providing information regarding gene expression in the selected control sample. The expression of the selected gene, or genes, (selected from the group of genes set out in Table 1) in comparator samples of this type may be investigated using the methods described herein in connection with the investigation of gene expression in the scar of interest.

Although tissue or organ samples constituting comparator samples, or extracts from such samples, may be used directly as the source of information regarding gene expression in the comparator sample (as discussed elsewhere in the specification), it will generally be preferred that information regarding the expression of the selected gene (or genes) in the comparator sample be provided in the form of reference data. Such reference data may be provided in the form of tables indicative of gene expression in the chosen comparator tissue. Alternatively, the reference data may be supplied in the form of computer software containing retrievable information indicative of gene expression in the chosen comparator tissue. The reference data may, for example, be provided in the form of an algorithm enabling comparison of expression of at least one selected gene (or genes) in the scar of interest with expression of the same gene (or genes) in the comparator tissue sample.

In a preferred embodiment of the invention, a diagnosis as to whether the scar of interest is keloid or non-keloid may be delivered automatically on inputting results representative of expression of selected genes in the scar of interest into a predictive algorithm that has been trained upon data representative of gene expression in a suitable comparator sample. Well-established and commonly used classification systems include, but are not limited to, K-Nearest Neighbours, Centroid Classification, Linear Discriminant Analysis, Neural Networks and Support Vector Machines available, for example, in the Partek Genomics Suite software package (Partek Inc.).

A suitable sample representative of gene expression in a scar of interest or comparator sample may provide qualitatitive and/or quantitative information regarding gene expression. For the purpose of the present invention qualitative information regarding gene expression is to be considered to be information that provides identification as to genes expressed in a scar of interest or comparator sample, without providing information as to the relative amounts of expression (save as to whether a particular gene is, or is not, expressed). It will be appreciated that in some situations qualitative information may allow a sufficient comparison between expression in the scar of interest and the comparator sample to allow a diagnosis as to whether the scar of interest is keloid or non-keloid.

Qualitative information may be particularly suitable for diagnoses that are based on decreased expression of genes of Table 1 that are normally expressed in comparator samples, but are not expressed at all in keloids. In such cases the lack of expression of the gene the scar of interest will be sufficient to indicate an elevated risk of keloid formation. Examples include those genes identified by Gene Identification Numbers 2, 3 and 4 and it may be a preferred embodiment of the invention to investigate expression of these genes. The inventors have found that these genes may be used as the basis of a diagnosis when their expression is compared (quantitatively or qualitatively) between an intra-lesional scar of interest and a normal skin comparator.

It will, however, generally be preferred to use a sample capable of providing quantitative information regarding gene expression in the scar of interest or comparator sample. Such information allows ready comparison between the levels of expression in the scar of interest and the levels of expression in the comparator sample. For the purposes of the present invention quantitative information relating to gene expression may be taken to refer to either absolute or relative quantification. Methods by which absolute or relative quantitation may be achieved are discussed further below.

Samples representative of gene expression in the scar of interest or comparator sample will generally contain target molecules that are directly or indirectly representative of gene expression. Suitable samples may be provided in the form of tissue samples containing such target molecules, or, preferably as tissue extracts. A tissue extract representative of gene expression in a scar of interest will generally contain isolated target molecules that are representative of gene expression in the tissue from which the extract is obtained.

Suitable techniques by which tissue samples or tissue extracts may be obtained and prepared in order that they may provide information as to gene expression may be selected with reference to the type of target molecule that is to be employed. Examples of appropriate techniques that may be used will be readily apparent to the skilled person, however guidance as to suitable techniques is also provided elsewhere in the specification.

It will be appreciated that protein target molecules represent target molecules that are particularly amenable to direct detection. Such direct detection may provide qualitative or quantitative information as to the amount of the protein present in the scar of interest or comparator sample, thereby allowing comparison of expression.

In a preferred instance, the amount of certain target proteins present in a sample may also be assessed with reference to the biological activity of the target in the sample. Assessment and comparison of expression in this manner is particularly suitable in the case of protein targets having enzyme activity. Examples of genes set out in Table 1 having enzyme activity, and so particularly suitable for investigation in this manner, include those identified by Gene Identification Numbers 8, 22, 24, 29, 44, 46, 54, 56, 60, 69, 70, 75, 93, 94, 97, 102, 123, 133, 138, 147, 148, 150, 152, 159, 167, 170, 186, 194, 195, 209, 216, 221, 228, 232, 234, 239, 243, 262, 268, 289, 291, 293, 304, 306, 323, 324, 326, 357, 358, 359, 361, 366, 382, 385, 395, 398, 400, 402, 412, 419, 420, 437, 440, 446, 452, 456, 459, 460, 466, 467, 469, 472, 485, 486, 502, 505, 514, 516, 517, 534, 540, 558, 563, 569, 575, 581, 582 and 587. Enzyme activity of protein targets may, for example, be investigated by analysing breakdown of labelled enzyme substrate, and the amount of enzyme activity thereby correlated with gene expression occurring in the scar of interest or comparator sample. Merely by way of example, those enzymes identified by Gene Identification Nos. 56, 366, 412 and 581 all possess proteolytic activity, and it would therefore be possible to assess the presence or absence of these enzymes with reference to their ability to proteolytically degrade their substrates.

The presence or absence of target molecules in a tissue sample or extract will generally be detected using suitable probe molecules (although there may be some instances, such as those discussed above, where presence or absence of a target molecule may be determined directly without the need for a probe). Such detection will provide information as to gene expression, and thereby allow comparison between gene expression occurring in the scar of interest and expression occurring in the comparator sample. Diagnosis in accordance with the invention may be carried out based on such comparisons.

Probes will generally be capable of binding specifically to target molecules directly or indirectly representative of gene expression in the scar of interest or comparator sample. Binding of such probes may then be assessed and correlated with gene expression to allow an effective diagnostic comparison between gene expression in the scar of interest and in the comparator. Suitable probes that may be used in the methods, kits and arrays of the invention are discussed elsewhere in the specification.

Target molecules suitable for use in the methods, kits and arrays of the invention are molecules representative of gene expression either directly or indirectly, as considered in greater detail below. Target molecules may include mRNA gene transcripts, as well as natural and artificial products of such transcripts (e.g. proteins or cDNA respectively). It will be appreciated that samples for use in accordance with the present invention should be processed in a manner selected with reference to the nature of the target molecule that is to be used. Suitable protocols for processing of tissues to yield samples containing usable target molecules are discussed further below.

Suitable target molecules may comprise the direct products of gene expression. Such direct products of gene expression may, for example, comprise one or more gene transcripts representative of gene expression. The use of mRNA gene transcripts as target molecules allowing comparison of gene expression in the scar of interest with expression in the comparator sample is a preferred embodiment of the invention.

Alternatively, a sample representative of gene expression in the scar of interest or comparator sample may comprise target molecules that are indirectly representative of gene expression. Examples of such targets indirectly representative of gene expression may include natural products (such as proteins) that are produced on translation of a gene transcript, as well as artificial products generated from gene transcripts. Preferred examples of artificial target molecules generated from gene transcripts include cDNA and cRNA, either of which may be generated using well known protocols or commercially available kits or reagents.

For example, in a preferred embodiment, RNA representative of gene expression in a scar of interest or comparator sample may be isolated through a process of lysing cells taken from a suitable sample (which may be achieved using a commercially available lysis buffer such as that produced by Qiagen Ltd.) followed by centrifugation of the lysate using a commercially available nucleic acid separation column (such as the RNeasy midi spin column produced by Qiagen Ltd). Other methods for RNA extraction include variations on the phenol and guanidine isothiocyanate method of Chomczynski, P. and Sacchi, N. (1987) Analytical Biochemistry 162, 156. “Single Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction.” RNA obtained in this manner may constitute a suitable target molecule itself, or may serve as a template for the production of target molecules representative of gene expression.

It may be preferred that RNA derived from a scar of interest or comparator sample may be used as substrate for cDNA synthesis, for example using the Superscript System (Invitrogen Corp.). The resulting cDNA may then be converted to biotinylated cRNA (for instance using the BioArray RNA Transcript labelling kit from Enzo Life Sciences Inc.) and this cRNA purified from the reaction mixture (for instance using an RNeasy mini kit from Qiagen Ltd).

In the case of protein target molecules, gene expression may be assessed with reference to the total amount of the protein target present. Suitable techniques for the measurement of the amount of a protein target present in a sample representative of gene expression in a scar of interest or comparator sample include, but are not limited to, aptamers and antibody-based techniques, such as radio-immunoassays (RIAs), enzyme-linked immunoassays (ELISAs) and Western blotting, immuno-PCR and multiplex approaches such as those using beads or microspheres (for example xMap technology from Luminex Inc), (Bloom and Dean (2003) Biomarkers in Clinical Drug Development; Crowther (1995) Elisa Theory and Practice (Humana Press); Singh et al (1993) Diagnostics in the year 2000: Antibody, Biosensor and nucleic acid Technologies (Van Nostrand Reinhold, New York); Niemeyer C M, Adler M, Wacker R. Immuno-PCR: high sensitivity detection of proteins by nucleic acid amplification. Trends Biotechnol. 2005 April; 23(4):208-16; Abreu I, Laroche P, Bastos A, Issert V, Cruz M, Nero P, Fonseca J E, Branco J, Machado Caetano J A. Multiplexed immunoassay for detection of rheumatoid factors by FIDISTM technology. Ann N Y Acad Sci. 2005 June; 1050:357-63).

The disclosures of the documents set out in the preceding paragraphs are incorporated by reference, insofar as they describe methods that may useful to the skilled person in practising the present invention.

In the event that expression of one or more genes from Table 1 in a comparator sample is to be investigated via processing of a tissue or organ sample constituting the comparator sample, or by processing of a tissue extract representative of gene expression in the comparator sample, for example to isolate suitable target molecules, it is preferred that such processing is conducted using the same methods used to process the sample from the scar of interest. Such parallel processing of samples from both the scar of interest and comparator tissue allows a greater degree of confidence that comparisons of gene expression in these tissues will be normalised relative to one another (since any artifacts associated with the selected method by which tissue is processed and gene expression investigated will be applied to both the scar of interest and comparator samples).

Furthermore, the parallel processing of the comparator sample in this manner provides an “internal control” that will allow the practitioner to confirm that processing has occurred successfully. Since the practitioner will be aware that the selected one or more genes from Table 1 that have been selected for comparison of expression are normally expressed by comparator tissues, the practitioner will be able to discount any instances of processing (for investigation of gene expression) which give rise to assays indicating that expression of these internal controls cannot be detected (since these results will likely be as a result of a processing error leading to artificially low readings). Such results may otherwise give rise to an incorrect assessment that the scar of interest comprises keloid tissue (since the same artificial decrease in assessed expression would be noted in respect of the selected gene or genes from Table 1).

Samples representative of gene expression in a scar of interest, or a comparator tissue, may be manipulated prior to effecting comparison of gene expression. Such manipulation may, for example, be designed to make comparison of expression easier, or to increase the information made available by the comparison. Examples of suitable ways in which such samples may be manipulated are considered below.

Preferably the methods or kits of the invention will provide means by which the expression data relating to the scar of interest and comparator tissue may be “normalised” with respect to one another. Normalisation ensures that comparisons being made are “like for like”, and suitable parameters for use in normalisation are well known to those skilled in the art. Purely by way of illustration, normalisation may be effected with reference to cell numbers in the samples to be compared; and/or total protein content of samples to be compared; and/or total nucleic acid content of samples to be compared; and/or expression level of one or more genes the expression of which does not change between keloid and non-keloid tissues. Alternatively or additionally, a suitable control may involve assessing expression of one or more genes known to be expressed in keloids. Detection of the expression of such genes (in combination with the reduced expression of one or more of the genes set out in Table 1) will provide a suitable control against which gene expression can be referenced. Suitable examples of such genes are considered elsewhere in the specification.

The inventors have found that preferred samples representative of gene expression for use in accordance with the present invention are those samples comprising nucleic acid target molecules representative of gene expression. For the purposes of the present invention a nucleic acid target is a nucleic acid the presence or absence of which is to be detected, or the amount of which present is to be quantified. Such detection or quantification will allow a diagnostic comparison of expression to be effected. A target nucleic acid may preferably have a sequence that is complementary to the nucleic acid sequence of a corresponding probe directed to the target. A nucleic acid target in accordance with the present invention may encompass both a specific subsequence of a larger nucleic acid to which a probe is directed or, alternatively, the overall sequence (e.g. complete mRNA transcript) whose expression level it is desired to detect. Suitable nucleic acid targets may include both RNAs and DNAs, and encompass both naturally occurring and artificial nucleic acids.

It will be understood that target nucleic acids suitable for use in accordance with the invention need not comprise “full length” nucleic acids (e.g. full length gene transcripts), but need merely comprise a sufficient length to allow specific binding of probe molecules.

It will be understood that “nucleic acids” or “nucleic acid molecules” for the purposes of the present invention refer to a deoxyribonucleotide or ribonucleotide polymers in either single- or double-stranded form. Furthermore, unless the context requires otherwise, these terms should be taken to encompass known analogues of natural nucleotides that can function in a similar manner to naturally occurring nucleotides.

mRNA constitutes a preferred form of target molecule that may be used in the methods and kits of the invention. mRNA gene transcripts are directly representative of gene expression in the scar of interest or comparator sample.

It will be recognised that mRNA, representative of gene expression, may be found directly in a scar of interest or comparator sample, without the need for mRNA extraction or purification. For example, mRNA present in, and representative of gene expression in, a scar of interest or comparator sample may be investigated using appropriately fixed sections or biopsies of such a tissue. The use of samples of this kind may provide benefits in terms of the rapidity with which comparisons of expression can be made, as well as the relatively cheap and simple tissue processing that may be used to produce the sample. In situ hybridisation techniques represent preferred methods by which gene expression may be investigated and compared in tissues samples of this kind. Techniques, for the processing of scars of interest that maintain the availability of RNA representative of gene expression in the scar of interest or comparator sample are well known to those of skill in the art.

However, techniques by which mRNAs representative of gene expression in a scar of interest or comparator sample may be extracted and collected are well known to those skilled in the art, and the inventors have found that such techniques may be advantageously employed in accordance with the present invention. Samples comprising extracted mRNA from a scar of interest or comparator sample may be preferred for use in the methods and kits of the invention, since such extracts tend to be more readily investigated than is the case for samples comprising the original tissues. For example, suitable target molecules allowing for comparison of gene expression may comprise the total RNA isolated from a sample of the scar of interest, or a sample of comparator tissue.

Furthermore, extracted RNA may be readily amplified to produce an enlarged mRNA sample capable of yielding increased information on gene expression in the scar of interest or comparator sample. Suitable examples of techniques for the extraction and amplification of mRNA populations are well known, and are considered in more detail below.

By way of example, methods of isolation and purification of nucleic acids to produce nucleic acid targets suitable for use in accordance with the invention are described in detail in Chapter 3 of Laboratory Techniques in Biochemistry and Molecular Biology:

Hybridization With Nucleic Acid Probes, Part I. Theory and Nucleic Acid Preparation, P. Tijssen, ed. Elsevier, N.Y. (1993).

In a preferred method, the total nucleic acid may be isolated from a given sample using, for example, an acid guanidinium-phenol-chloroform extraction method.

In the event that it is desired to amplify the nucleic acid targets prior to investigation and comparison of gene expression it may be preferred to use a method that maintains or controls for the relative frequencies of the amplified nucleic acids in the scar of interest or control tissue from which the sample is derived.

Suitable methods of “quantitative” amplification are well known to those of skill in the art. One well known example, quantitative PCR involves simultaneously co-amplifying a control sequence whose quantities are known to be unchanged between comparator samples and those from the scar of interest. This provides an internal standard that may be used to calibrate the PCR reaction.

In addition to the methods outlined above, the skilled person will appreciate that any technology coupling the amplification of gene-transcript specific product to the generation of a signal may also be suitable for quantitation. A preferred example employs convenient improvements to the polymerase chain reaction (U.S. Pat. No. 4,683,195 and 4683202) that have rendered it suitable for the exact quantitation of specific mRNA transcripts by incorporating an initial reverse transcription of mRNA to cDNA. Further key improvements enable the measurement of accumulating PCR products in real-time as the reaction progresses. Examples of suitable technologies using fluorescent resonance energy transfer to generate a quantitative gene-specific signal include Taqman (U.S. Pat. No. 5,210,015 and 5487972), molecular beacons (WO-95/13399) and scorpions (US2005/0164219). The parallel quantitation of multiple transcripts is possible via the use of different fluorescent moieties for each gene target.

Other suitable amplification methods include, but are not limited to Nucleic acid sequence based amplification (NASBA) (Saad F. UPM3: review of a new molecular diagnostic urine test for prostate cancer. Can J Urol. 2005 February; 12 Suppl 1:40-3); Rolling Circle Amplification (RCA) (Gomez K F, Lane J, Cunnick G, Grimshaw D, Jiang W G, Mansel R E. From PCR to RCA: a surgical trainee's guide to the techniques of genetic amplification. Eur J Surg Oncol. 2002 August; 28(5):554-9); Branched Chain Nucleic Acids (BCNA) (Andras S C, Power J B, Cocking E C, Davey M R. Strategies for signal amplification in nucleic acid detection. Mol Biotechnol. 2001 September; 19(1):29-44); the invader assay (de Arruda M, Lyamichev V I, Eis P S, Iszczyszyn W, Kwiatkowski R W, Law S M, Olson M C, Rasmussen E B. Invader technology for DNA and RNA analysis: principles and applications. Expert Rev Mol Diagn. 2002 September; 2(5):487-96); ligase chain reaction (LCR) (see Wu and Wallace, Genomics, 4: 560 (1989), Landegren, et al., Science, 241: 1077 (1988) and Barringer, et al., Gene, 89: 117 (1990), transcription amplification (Kwoh, et al., Proc. Natl. Acad. Sci. USA, 86: 1173 (1989)), and self-sustained sequence replication (Guatelli, et al., Proc. Nat. Acad. Sci. USA, 87: 1874 (1990)).

In a particularly preferred embodiment, the mRNA transcripts from a tissue representative of gene expression in a scar of interest or comparator sample may be reverse transcribed with a reverse transcriptase and a promoter consisting of oligo dT and a sequence encoding the phage T7 promoter to provide single stranded DNA template. The second DNA strand is polymerized using a DNA polymerase. After synthesis of double-stranded cDNA, T7 RNA polymerase is added and RNA is transcribed from the cDNA template. Successive rounds of transcription from each single cDNA template results in amplified RNA. Methods of in vitro polymerization are well known to those of skill in the art (see, e.g., Sambrook, supra.) and this particular method is described in detail by Van Gelder, et al., Proc. Natl. Acad. Sci. USA, 87: 1663-1667 (1990) who demonstrate that in vitro amplification according to this method preserves the relative frequencies of the various RNA transcripts. Moreover, Eberwine et al. Proc. Natl. Acad. Sci. USA, 89: 3010-3014 (1992) provide a protocol that uses two rounds of amplification via in vitro transcription to achieve greater than 10⁶fold amplification of the original starting material, thereby permitting expression monitoring even when only a small sample of the scar of interest is available.

It will be appreciated by one of skill in the art that the direct transcription method described above leads to the production of antisense RNA (aRNA) targets. In such cases probes, such as oligonucleotide probes, to be used to investigate and compare gene expression should be chosen to be complementary to sequences or sub-sequences of the antisense nucleic acids.

The skilled person will further appreciate that artificial nucleic acid molecules may also be used in the comparison of gene expression. Examples of artificial target molecules suitable for use in accordance with the present invention include cDNAs made by reverse transcription of mRNA or second strand cDNA or RNA (cRNA) transcribed from a double stranded cDNA intermediate. Methods for the production of cDNAs and cRNAs are well documented in the art, and will be known to the skilled person, and indeed kits and reagents suitable for their production are readily commercially available.

For the purposes of the present invention, a sample that is “representative” of gene expression in a scar of interest is to be considered to encompass any sample providing information as to the expression of genes in the scar of interest. For example, a representative sample may provide information as to all the genes expressed in the scar of interest, and preferably the relative levels of expression of said genes.

In a preferred embodiment, a representative sample is one in which the concentration of target molecules is proportional to the concentration of mRNA gene transcripts of the gene (or genes) expression of which, in the scar of interest, is to be compared to comparators. While it is preferred that the proportionality be relatively strict (e.g., a doubling in the number of mRNA gene transcript occurring in the scar of interest leading to a doubling in the number of corresponding target molecules present in the sample), the skilled person will appreciate that the proportionality can be more relaxed and even non-linear. For example, an assay where a five fold difference in concentration of the mRNA gene transcripts in the scar of interest results in a three to six fold difference in the concentration of target molecules in the representative sample is sufficient for most purposes.

In the event that more precise quantification is required, serial dilutions of “standard” target molecules can be used to prepare calibration curves according to methods well known to those skilled in the art. More preferably quantitation of target molecules will be relative and normalised with respect to each other and/or “housekeeping” genes whose expression levels are not increased in keloid forming as compared to non-keloid forming tissues. Examples of such genes include exportin 7 (XPO7), Cleavage and Polyadenylation Specific Factor 4, 30 kDa (CPSF4), F-box only protein 7 (FBXO7), ADP-ribosylation factor 1 (ARF1), signal sequence receptor, beta (SSR2) and methionine-tRNA synthetase (MARS).

It will, of course, be appreciated that in the case of a qualitative sample or samples (where simple detection of the presence or absence of gene expression is desired) no such elaborate control or calibration is required.

Although it may be preferred in many instances that the representative sample provides information as to all genes expressed in the scar of interest or comparator sample, a suitable representative sample may alternatively provide information relating to the expression of only a sub-set of the total number of genes undergoing expression.

In many cases it may be preferred to assess the degree of gene expression in a scar of interest or comparator sample using probe molecules capable of indicating the presence of target molecules (representative of one or more of the genes set out in Table 1) in the relevant sample.

The use of target molecules and probes in methods, kits or assays in accordance with the present invention may confer increased sensitivity on the methods of the invention. This may lead to an increased ability to discriminate between otherwise small differences between expression in the scar of interest and expression in the comparator sample. This will have appreciable benefits on diagnosis in accordance with the invention.

Generally, suitable probes for use in the present invention will bind to their target molecules, and thereby allow detection of the target molecule (this detection being indicative of expression of the gene selected from Table 1 represented by the target molecule).

It may be preferred that probes for use in accordance with the invention allow replication of the target molecules (suitably in combination with the probe molecule). Replication in this manner produces a greater number of target molecules, and thus allows further binding of the labelled probe. In turn, the increased amount of labelled probe thus bound amplifies the detectable signal indicative of gene expression.

Probes for use in the methods and kits of the invention may be selected with reference to the product (direct or indirect) of gene expression to be investigated. Examples of suitable probes include oligonucleotide probes, antibodies, aptamers, and binding proteins or small molecules having suitable specificity.

Oligonucleotide probes constitute preferred probes suitable for use in accordance with the methods and kits of the invention. The generation of suitable oligonucleotide probes is well known to those skilled in the art (Oligonucleotide synthesis: Methods and Applications, Piet Herdewijn (ed) Humana Press (2004).). Oligonucleotide and modified oligonucleotides are commercially available from numerous companies.

An oligonucleotide is a single-stranded nucleic acid ranging in length from 2 to about 500 nucleotide bases, preferably from about 5 to about 50 nucleotides, more preferably from about 10 to about 40 nucleotides and most preferably from about 15 to about 40 nucleotides in length. Suitable hybridization methods, conditions, times, fluid volumes, and suitable methods by which hybridisation of oligonucleotide probes may be detected are as described elsewhere in the present specification.

For the purposes of the present invention an oligonucleotide probe may be taken to comprise an oligonucleotide capable of hybridising specifically to a target nucleic acid of complementary sequence through one or more types of chemical bond. Such binding may usually occur through complementary base pairing, and usually through hydrogen bond formation. Suitable oligonucleotide probes may include natural (ie., A, G, C, or T) or modified bases (7-deazaguanosine, inosine, etc.). In addition, a linkage other than a phosphodiester bond may be used to join the bases in an oligonucleotide probe, so long as this variation does not interfere with hybridisation of the oligonucleotide probe to its target. Thus, oligonucleotide probes suitable for use in the methods and kits of the invention may be peptide nucleic acids in which the constituent bases are joined by peptide bonds rather than phosphodiester linkages.

The phrase “hybridising specifically to” as used herein refers to the binding, duplexing, or hybridising of an oligonucleotide probe preferentially to a particular target nucleotide sequence under stringent conditions when that sequence is present in a complex mixture (such as total cellular DNA or RNA). Preferably a probe may bind, duplex or hybridise only to the particular target molecule.

The term “stringent conditions” refers to conditions under which a probe will hybridise to its target subsequence, but minimally to other sequences. Preferably a probe may hybridise to no sequences other than its target under stringent conditions. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridise specifically at higher temperatures.

In general, stringent conditions may be selected to be about 5° C. lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength and pH. The Tm is the temperature (under defined ionic strength, pH, and nucleic acid concentration) at which 50% of the oligonucleotide probes complementary to a target nucleic acid hybridise to the target nucleic acid at equilibrium. As the target nucleic acids will generally be present in excess, at Tm, 50% of the probes are occupied at equilibrium. By way of example, stringent conditions will be those in which the salt concentration is at least about 0.01 to 1.0 M Na ion concentration (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C. for short probes (e.g., 10 to 50 nucleotides). Stringent conditions may also be achieved with the addition of destabilizing agents such as formamide.

Considerations for the design and selection of probes suitable for use with antisense nucleic acid targets (aRNA) have been discussed above. In the case that the nucleic acid targets comprise sense nucleic acids, suitable oligonucleotide probes may be selected to be complementary to sequences or sub-sequences of the sense nucleic acids. In the case of nucleic acid targets that are double stranded, suitable probes may be of either sense as the nucleic acid targets will provide both sense and antisense strands.

Antibodies suitable for use in the methods or kits of the invention may be used to detect target molecules, such as proteins, that represent gene expression in a scar of interest.

Antibodies that may be used to investigate gene expression in accordance with the methods and kits of the present invention include monoclonal antibodies and polyclonal antibodies, as well as fragments of such antibodies, including, but not limited to, Fab or F(ab′)hd 2, and Fv fragments.

Methods suitable for the generation and/or identification of antibodies capable of binding specifically to a given target are well known to those skilled in the art. In general suitable antibodies may be generated by the use of the isolated target as an immunogen. This immunogen is administered to a mammalian organism, such as, but not limited to, a rat, rabbit, goat or mouse, and antibodies elicited as part of the immune response. Generally antibodies will be used in the context of the methods and kits of the invention to bind to protein products of gene expression. Suitable immunogens may include the full-length protein to be investigated, or an antigenic peptide fragment thereof.

Monoclonal antibodies can be produced by hybridomas, immortalized cell lines capable of secreting a specific monoclonal antibody. The immortalized cell lines can be created in vitro by fusing two different cell types, usually lymphocytes, one of which is a tumour cell.

Aptamers are nucleic acid molecules that assume a specific, sequence-dependent shape and bind to specific target ligands based on a lock-and-key fit between the aptamer and ligand. Typically, aptamers may comprise either single- or double-stranded DNA molecules (ssDNA or dsDNA) or single-stranded RNA molecules (ssRNA).

Aptamers may be used to bind both nucleic acid and non-nucleic acid targets. Accordingly aptamers are suitable probes for use in the investigation of gene expression products including RNA, DNA and small molecules or proteins. Preferably aptamers may be used to investigate gene expression products having a molecular weight of between 100 and 10,000 Da. ssDNA aptamers may be preferred for use in the investigation of gene expression products comprising DNA.

Suitable aptamers may be selected from random sequence pools, from which specific aptamers may be identified which bind to the selected target molecules with high affinity. Methods for the production and selection of aptamers having desired specificity are well known to those skilled in the art, and include the SELEX (systematic evolution of ligands by exponential enrichment) process. Briefly, large libraries of oligonucleotides are produced, allowing the isolation of large amounts of functional nucleic acids by an iterative process of in vitro selection and subsequent amplification through polymerase chain reaction.

The use of aptamers for investigation of gene expression in accordance with the methods and kits of the invention may be advantageous, since aptamers have relatively stable shelf lives. Aptamers suitable for use in the methods and/or kits of the invention may preferably be stabilized by chemical modifications (for example 2′-NH₂and 2′-F modifications).

Photoaptamers are a subclass of aptamers incorporating at least one bromo-deoxyuridine (BrdU) in place of a thymidine (T) nucleotide. The presence of the BrdU enables photoaptamers to form a specific covalent crosslink with their target ligands when exposed to ultraviolet light. Because crosslinking requires both affinity-based binding and close proximity between a BrdU (at a specific location in the photoaptamer) and an amino acid (at a specific location in the target ligand), photoaptamers may be preferred for use in the methods and kits of the invention when increased specificity of binding with a gene expression product is required.

Suitable methods by which gene expression may be compared in accordance with the present invention may be selected in the light of the considerations referred to in the preceding pages.

In general methods for analysis may be selected based on the nature of a target molecule to be investigated, and suitable selection criteria may distinguish between nucleic acid and protein target molecules.

However, as set out above, it may generally be preferred to investigate and compare gene expression using oligonucleotide probes capable of binding to nucleic acid target molecules.

Oligonucleotide probes may be used to detect complementary nucleic acid sequences (i.e., nucleic acid targets) in a suitable representative sample. Such complementary binding forms the basis of most techniques in which oligonucleotides may be used to detect, and thereby allow comparison of, expression of particular genes. Preferred technologies permit the parallel quantitation of the expression of multiple genes and include technologies where amplification and quantitation of species are coupled in real-time, such as the quantitative reverse transcription PCR technologies previously described herein, and technologies where quantitation of amplified species occurs subsequent to amplification, such as array technologies.

Array technologies involve the hybridisation of samples, representative of gene expression within the scar of interest or comparator sample, with a plurality of oligonucleotide probes wherein each probe preferentially hybridises to a disclosed gene or genes. Array technologies provide for the unique identification of specific oligonucleotide sequences, for example by their physical position (e.g., a grid in a two-dimensional array as commercially provided by Affymetrix Inc.) or by association with another feature (e.g. labelled beads as commercially provided by Illumina Inc or Luminex Inc). Oligonucleotide arrays may be synthesised in situ (e.g by light directed synthesis as commercially provided by Affymetrix Inc) or pre-formed and spotted by contact or ink-jet technology (as commercially provided by Agilent or Applied Biosystems). It will be apparent to those skilled in the art that whole or partial cDNA sequences may also serve as probes for array technology (as commercially provided by Clontech).

Oligonucleotide probes may be used in blotting techniques, such as Southern blotting or northern blotting, to detect and compare gene expression (for example by means of cDNA or mRNA target molecules representative of gene expression). Techniques and reagents suitable for use in Southern or northern blotting techniques will be well known to those of skill in the art. Briefly, samples comprising DNA (in the case of Southern blotting) or RNA (in the case of northern blotting) target molecules are separated according to their ability to penetrate a gel of a material such as acrylamide or agarose. Penetration of the gel may be driven by capillary action or by the activity of an electrical field. Once separation of the target molecules has been achieved these molecules are transferred to a thin membrane (typically nylon or nitrocellulose) before being immobilized on the membrane (for example by baking or by ultraviolet radiation). Gene expression may then be detected and compared by hybridisation of oligonucleotide probes to the target molecules bound to the membrane. More details of suitable conditions in which hybridisation may be effected are provided below, as are examples of techniques by which hybridisation may be detected.

In certain circumstances the use of traditional hybridisation protocols for comparing gene expression may prove problematic. For example blotting techniques may have difficulty distinguishing between two or more gene products of approximately the same molecular weight since such similarly sized products are difficult to separate using gels. Accordingly, in such circumstances it may be preferred to compare gene expression using alternative techniques, such as those described below.

Gene expression in a sample representing gene expression in a scar of interest may be assessed with reference to global transcript levels within suitable nucleic acid samples by means of high-density oligonucleotide array technology. Such technologies make use of arrays in which oligonucleotide probes are tethered, for example by covalent attachment, to a solid support. These arrays of oligonucleotide probes immobilized on solid supports represent preferred components to be used in the methods and kits of the invention for the comparison of gene expression. Large numbers of such probes may be attached in this manner to provide arrays suitable for the comparison of expression of large numbers of genes selected from those set out in Table 1. Accordingly it will be recognised that such oligonucleotide arrays may be particularly preferred in embodiments of the methods or kits of the invention where it is desired to compare expression of more than one gene selected from Table 1 in order to effect a diagnosis.

In a preferred embodiment investigation of gene expression using oligonucleotide arrays may be effected by hybridisation of oligonucleotide probes and nucleic acid targets at low stringency followed by at least one wash at higher stringency. Low stringency conditions suitable for use in accordance with these embodiments may comprise a reaction temperature of about 20° C. to about 50° C. (more preferably about 30° C. to about 40° C., and most preferably about 37° C.) and 6×SSPE-T buffer (or lower). Suitable hybridisation protocols may include subsequent washes at progressively increasing stringency until a desired level of hybridisation specificity is reached. Hybridisation stringency may also be varied by electronic means, for example as provided by Nanogen Inc. (Sosnowski R, Heller M J, Tu E, Forster A H, Radtkey R. Active microelectronic array system for DNA hybridization, genotyping and pharmacogenomic applications. Psychiatr Genet. 2002 December; 12(4):181-92).

Suitable techniques for the detection of hybridisation between oligonucleotide probes and nucleic acid targets are considered further below.

The identity of selected oligonucleotide probes incorporated in arrays may be altered to allow more detailed selection of the genes, the expression of which is to be compared. For example arrays suitable for use in the methods or kits of the invention may comprise one or more oligonucleotide probes selected with reference to the differential expression of selected genes from Tables 1 to 28 as considered previously.

Alternatively, assessment of gene expression in a scar of interest or comparator sample based on levels of nucleic acids sequences (such as mRNA or DNA) in a sample representative of gene expression in the scar of interest or comparator may be undertaken using other suitable techniques that will be apparent to the skilled person. For example, northern blotting provides a sensitive method by which levels of mRNA representative of gene expression in a scar of interest or comparator sample may be assessed.

Other suitable methodologies that may be used in the comparison of nucleic acid targets representative of gene expression include, but are not limited to, nucleic acid sequence based amplification (NASBA); rolling circle DNA amplification (RCA); branched chain nucleic acid and invader assays; the use of aptamers, antibodies or antibody derivatives (Singh et al, 1993; Boeckh and Boivin 1998; Bloom and Dean, 2003; Jain, 2004; Millar and Moore, 2004; Olson, 2004; Yang and Rothman, 2004).

As described previously, gene expression in a scar of interest or comparator sample may alternatively be investigated using samples comprising proteins representative of gene expression. Suitable techniques by which such protein samples may be investigated to assess gene expression include, but are not limited to, aptamer detection; mass spectrometry; nuclear magnetic resonance (NMR); antibody-based methods such as immuno-PCR and multiplex approaches such as those using arrays, beads or microspheres (for example xMap technology from Luminex Inc), ELISA, RIA and Western blotting; and other methods well known to those skilled in the art (Bloom and Dean (2003) Biomarkers in Clinical Drug Development; Crowther (1995) Elisa Theory and Practice (Humana Press); Singh et al (1993) Diagnostics in the year 2000: Antibody, Biosensor and nucleic acid Technologies (Van Nostrand Reinhold, New York); Niemeyer C M, Adler M, Wacker R. Immuno-PCR: high sensitivity detection of proteins by nucleic acid amplification. Trends Biotechnol. 2005 April; 23(4):208-16; Abreu I, Laroche P, Bastos A, Issert V, Cruz M, Nero P, Fonseca J E, Branco J, Machado Caetano J A. Multiplexed immunoassay for detection of rheumatoid factors by FIDISTM technology. Ann N Y Acad Sci. 2005 June; 1050:357-63).

For instance, expression of proteins having enzymatic activity may be investigated and compared using assays based around activity of the protein in question. Enzymatic protein extracts (here constituting samples representative of gene expression in the scar of interest or comparator sample) may, for example, be incubated with samples comprising known quantities of the appropriately labelled substrate. The amount of enzymatic activity, and hence an indication of the level of gene expression in the scar of interest or comparator sample, may be determined by the amount of substrate converted by the enzyme.

Detection of probe or target molecules can be facilitated by coupling (i.e., physical linking) of such molecules to a detectable moiety. Alternatively suitable probe or target molecules may be synthesised such that they incorporate detectable moieties. Techniques that may be used in the coupling or incorporation of detectable moieties in probe or target molecules suitable for use in the method, kits or arrays of the invention are considered below.

Examples of detectable moieties that may be used in the labelling of probes or targets suitable for use in accordance with the invention include any composition detectable by spectroscopic, photochemical, biochemical, immunochemical, electrical, optical or chemical means. Suitable detectable moieties include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, radioactive materials and colorimetric materials. These detectable moieties are suitable for incorporation in all types of probes or targets that may be used in the methods or kits of the invention unless indicated to the contrary.

Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, beta-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride, phycoerythrin, texas red, rhodamine, green fluorescent protein, and the like; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin; examples of suitable radioactive material include ¹²⁵I, ¹³¹I, ³⁵S, ³H, ¹⁴C, or ³²P; examples of suitable colorimetric materials include colloidal gold or coloured glass or plastic (e.g., polystyrene, polypropylene, latex, etc.) beads.

Means of detecting such labels are well known to the skilled person. For example, radiolabels may be detected using photographic film or scintillation counters; fluorescent markers may be detected using a photodetector to detect emitted light. Enzymatic labels are typically detected by providing the enzyme with a substrate and detecting the reaction product produced by the action of the enzyme on the substrate, and colorimetric labels are detected by simply visualizing the coloured label.

In a preferred embodiment of the invention fluorescently labelled probes or targets may be scanned and fluorescence detected using a laser confocal scanner.

In the case of labelled nucleic acid probes or targets suitable labelling may take place before, during, or after hybridisation. In a preferred embodiment, nucleic acid probes or targets for use in the methods or kits of the invention are labelled before hybridisation. Fluorescence labels are particularly preferred and, where used, quantification of the hybridisation of the nucleic acid probes to their nucleic acid targets is by quantification of fluorescence from the hybridised fluorescently labelled nucleic acid. More preferably quantitation may be from a fluorescently labelled reagent that binds a hapten incorporated into the nucleic acid.

In a preferred embodiment of the invention analysis of hybridisation may be achieved using suitable analysis software, such as the Microarray Analysis Suite (Affymetrix Inc.) and diagnosis automated by use of classification software (for example Partek Genomics Suite from Partek Inc).

Effective quantification may be achieved using a fluorescence microscope which can be equipped with an automated stage to permit automatic scanning of the array, and which can be equipped with a data acquisition system for the automated measurement, recording and subsequent processing of the fluorescence intensity information. Suitable arrangements for such automation are conventional and well known to those skilled in the art.

In a preferred embodiment, the hybridised nucleic acids are detected by detecting one or more detectable moieties attached to the nucleic acids. The detectable moieties may be incorporated by any of a number of means well known to those of skill in the art.

However, in a preferred embodiment, such moieties are simultaneously incorporated during an amplification step in the preparation of the sample nucleic acids (probes or targets). Thus, for example, polymerase chain reaction (PCR) using primers or nucleotides labelled with a detectable moiety will provide an amplification product labelled with said moiety. In a preferred embodiment, transcription amplification using a fluorescently labelled nucleotide (e.g. fluorescein-labelled UTP and/or CTP) incorporates the label into the transcribed nucleic acids.

Alternatively, a suitable detectable moiety may be added directly to the original nucleic acid sample (e.g., mRNA, polyA mRNA, cDNA, etc. from the scar of interest) or to an amplification product after amplification of the original nucleic acid is completed. Means of attaching labels such as fluorescent labels to nucleic acids are well known to those skilled in the art and include, for example nick translation or end-labelling (e.g. with a labeled RNA) by kinasing of the nucleic acid and subsequent attachment (ligation) of a nucleic acid linker joining the sample nucleic acid to a label (such as a suitable fluorophore).

As set out previously, in addition to the methods and kits described above, the invention also provides a kit for diagnosing a scar of interest as keloid or non-keloid, the kit comprising:

i) at least one probe capable of binding specifically to a target molecule representative of expression in a scar of interest of at least one gene selected from the group set out in Table 1; and

ii) reference material able to indicate the level of expression of said at least one gene in a comparator sample.

Preferably kits in accordance with this aspect of the invention may further comprise assay control material able to indicate that an assay has been performed correctly. Suitably such assay control material may include target molecules representative of expression of genes the expression of which does not vary between keloid and non-keloid tissues. Suitable examples of such housekeeping genes are considered elsewhere in the specification, and target molecules representative of expression of any of these genes may be advantageously provided in the kits of the invention. The provision of housekeeping genes of this sort in known quantities may provide a “standard” against which assay results may be normalised.

It may be preferred that a kit according to the present invention further comprises material (such as target molecules) representative of one or more genes whose expression is increased in keloid tissue. The provision of such genes may increase the ability to discriminate a biologically meaningful result from a change in the absolute input material or a change in the efficiency of any assay process. For example, lysyl oxidase displays a 3-fold higher expression in keloid tissue than in non-keloid tissue. Lysyl oxidase is a key enzyme involved in collagen cross-linking and has previously been shown to be highly expressed in fibrotic tissue.

Kits of the invention may further comprise materials for the preparation of a population of target molecules representative of gene expression in a scar of interest (or in a comparator tissue). Such materials may be suitable for the preparation of a population of nucleic acid target molecules. Alternatively such materials may be suitable for the preparation of a population of protein target molecules. It may be preferred that the kits comprise materials for the preparation of a population of labelled target molecules representative of gene expression in a scar of interest or comparator tissue.

It is also preferred that kits of the present invention may further comprise an algorithm or reference data/material able to indicate that the level of expression of said at least one gene, selected from the group set out in Table 1, in the scar of interest is diagnostic that the scar of interest is keloid tissue.

The algorithm may be provided in the form of a mathematical model of the difference in gene expression of said at least one gene, selected from the group set out in Table 1, between comparator data and data from scars of interest (such as known patient data). This mathematical model may then be deployed on gene expression data of said at least one gene, selected from the group set out in Table 1, from a new patient sample. The output thus generated will thus provide a diagnosis as to whether a scar of interest comprises keloid or non-keloid tissue.

Probes for inclusion in kits in accordance with this second aspect of the invention may be selected using the same criteria as for the first aspect of the invention. Suitable probes may be selected from the group comprising oligonucleotide probes, antibodies, aptamers and specific binding proteins.

Kits in accordance with the present invention may preferably comprise probes capable of binding specifically to target molecules representative of expression of up to five genes selected from the group set out in Table 1 (i.e. target molecules representative of the expression of up to five genes selected from Table 1). It is particularly preferred that kits of the invention comprise probes capable of binding 5, 6, 7, 8, 9 or 10 such target molecules. Kits may include probes capable of binding to up to 20 or up to 50 genes selected from those set out in Table 1. Suitable kits may comprise probes capable of binding to up to 100, 200, 300, 400 or 500 such target molecules. Indeed, kits of the invention may comprise probes capable of binding specifically to 500 or more target molecules, and may even comprise probes capable of binding specifically to targets representative of expression of all 590 of the genes set out in Table 1.

A kit of the invention will comprise probes capable of binding to target molecules representative of expression of at least one gene selected from Table 1, and/or probes capable of binding to target molecules representative of expression of at least one gene selected from Table 2, and/or probes capable of binding to target molecules representative of expression of at least one gene selected from Table 3, and/or probes capable of binding to target molecules representative of expression of at least one gene selected from Table 8, and/or probes capable of binding to target molecules representative of expression of at least one gene selected from Table 13, and/or probes capable of binding to target molecules representative of expression of at least one gene selected from Table 17, and/or probes capable of binding to target molecules representative of expression of at least one gene selected from Table 20, and/or probes capable of binding to target molecules representative of expression of at least one gene selected from Table 22, and/or probes capable of binding to target molecules representative of expression of at least one gene selected from Table 24, and/or probes capable of binding to target molecules representative of expression of at least one gene selected from Table 26.

Kits of the invention may include probes capable of binding to target molecules representative of gene expression of any of the genes set out in any one of (or any combination of) Tables 2 to 28.

The probes provided in the kits of the invention may preferably be labelled probes. Labelled probes may comprise any detectable moiety considered in connection with the first aspect of the invention. Preferred labelled probes may be chosen from the group comprising haptens, fluorescently labelled probes, radioactively labelled probes and enzymatically labelled probes.

The reference material provided in kits of the invention may comprise a library of nucleic acid targets representative of expression in an appropriate comparator sample of one or more genes selected from the group of genes set out in Table 1.

In a preferred embodiment the reference material may comprise recorded information regarding the level of expression of one or more genes selected from the group of genes set out in Table 1 in keloid and non-keloid tissue.

In a most preferred example the reference data may be used to create an algorithm which may deliver a diagnosis based upon the level of expression of one or more genes selected from the group of genes set out in Table 1.

Oligonucleotide probes provided in kits of the invention, may preferably be provided in the form of an oligonucleotide array as considered elsewhere in the specification.

It will be appreciated from the preceding pages that the use of oligonucleotide arrays is particularly useful in effecting a diagnosis in accordance with the present invention as to whether a scar of interest is keloid or non-keloid tissue.

Accordingly, in a third aspect of the invention there is provided an array of oligonucleotide probes, characterised in that at least 7.0% of the oligonucleotides probes present in the array are representative of genes selected from the group of genes set out in Table 1.

The invention also provides an array comprising immobilized antibody probes capable of binding specifically to molecules representative of expression of one or more of the group of genes set out in Table 1. Furthermore, the invention also provides an array comprising a nylon substrate to which are adhered nucleic acid probes representative of genes selected from the group of genes set out in Table 1. The nucleic acid probes may preferably be cDNA molecules.

Although a planar array surface is preferred, the array may be fabricated on a surface of virtually any shape or even a multiplicity of surfaces. In a further example a suitable array may be fabricated on the surface of a library of addressable beads, in which each bead displays a known nucleic acid sequence. Alternatively, a suitable array may be fabricated on the surface of a nylon substrate, typically a woven or non-woven nylon membrane.

It will be appreciated that arrays in accordance with the present invention can be used to compare the expression of a large number of genes set out in Table 1 simultaneously (and indeed to compare simultaneous expression of such genes), and that this gives rise to significant advantages in reduced labour, cost and time. Furthermore, the comparison of expression levels of multiple genes allows a greater degree of confidence in diagnoses that may be effected in accordance with the invention.

An array in accordance with the present invention may comprise up to five probes specific for genes selected from the group set out in Table 1. Preferably an array may comprise 5, 6, 7, 8, 9 or 10 probes specific for genes selected from the group set out in Table 1. Arrays may comprise probes specific for up to 20 or up to 50 genes selected from the group set out in Table 1. Suitable arrays may comprise up to 100, up to 200, up to 300, up to 400 or up to 500 probes specific genes selected from the group set out in Table 1. Indeed, suitable arrays may comprise probes specific for 500 or more of the genes set out in Table 1, and may even comprise probes specific for all 590 genes set out in Table 1. It will be appreciated that each of the probes should be specific for a different selected gene, and that more than one copy of each probe may be provided.

Arrays of the invention may comprise probes capable of binding to a target representative of expression of at least one gene selected from the group set out in Table 2, and/or probes capable of binding to a target representative of expression of at least one gene selected from the group set out in Table 3, and/or probes capable of binding to a target representative of expression of at least one gene selected from the group set out in Table 8, and/or probes capable of binding to a target representative of expression of at least one gene selected from the group set out in Table 13, and/or probes capable of binding to a target representative of expression of at least one gene selected from the group set out in Table 17, and/or probes capable of binding to a target representative of expression of at least one gene selected from the group set out in Table 20, and/or probes capable of binding to a target representative of expression of at least one gene selected from the group set out in Table 22, and/or probes capable of binding to a target representative of expression of at least one gene selected from the group set out in Table 24, and/or probes capable of binding to a target representative of expression of at least one gene selected from the group set out in Table 26.

An array according to the present invention may comprise probes capable of binding to targets representative of the expression of one or more genes selected from any one of, or any combination of, Tables 1 to 28.

It is preferred that an array according to the present invention may further comprise one or more genes whose expression is increased in keloid tissue. The provision of such genes may increase the ability to discriminate a biologically meaningful result from a change in the absolute input material or a change in the efficiency of any assay process. For example, lysyl oxidase displays a 3-fold higher expression in keloid tissue. Lysyl oxidase is a key enzyme involved in collagen cross-linking and has previously been shown to be highly expressed in fibrotic tissue.

The methods, kits and arrays of the invention may also make use of one or more “housekeeping genes” to provide a control by which the efficiency of any assay may be assessed. These housekeeping genes may be provided in the kits of the invention, or on the arrays of the invention. Suitable housekeeping genes will be those that are either invariant between keloid and non-keloid tissue or show no association with keloid formation. Examples of genes that display invariant expression in both keloid and non-keloid (comparator) biopsy samples include exportin 7 (XPO7), Cleavage and Polyadenylation Specific Factor 4, 30 kDa (CPSF4), F-box only protein 7 (FBXO7), ADP-ribosylation factor 1 (ARF1), signal sequence receptor, beta (SSR2) and methionine-tRNA synthetase (MARS).

Oligonucleotide arrays in accordance with the invention may be synthesized by any suitable technique known in the art. A preferred technique that may be used in the synthesis of such arrays is light-directed very large scaled immobilized polymer synthesis (VLSIPS), which has previously been described in a number of publications (Lipshutz R J, Fodor S P, Gingeras T R, Lockhart D J. High density synthetic oligonucleotide arrays. Nat Genet. 1999 January; 21(1 Suppl):20-4; Jacobs J W, Fodor S P. Combinatorial chemistry—applications of light-directed chemical synthesis. Trends Biotechnol. 1994 January; 12(1):19-26).

An oligonucleotide array in accordance with the invention may allow comparison of hybridisation, and thereby gene expression, to be carried out in extremely small fluid volumes (e.g., 250 μl or less, more preferably 100 μl or less, and most preferably 10 μl or less). This confers a number of advantages. In small volumes, hybridization may proceed very rapidly. In addition, hybridization conditions are extremely uniform throughout the sample, and the hybridization format is amenable to automated processing.

The skilled person will appreciate that diagnosis in accordance with the present invention (whether carried out using the methods, kits or arrays of the invention) may be useful in assessing the efficacy of a treatment employed to alleviate or cure keloid scarring. A keloid in which a treatment is producing a beneficial effect may be identified by virtue of its ability to alleviate the reduction of expression observed in respect of the genes set out in any of Tables 1 to 28.

A treatment that renders expression of one or more genes selected from Table 1 within a treated keloid more similar to the expression of said gene (or genes) found in a normal skin comparator should be viewed as having a beneficial effect on the keloid being treated. In the event that expression in a treated keloid is not rendered more similar to the expression found in a normal skin comparator, the treatment may be viewed as not beneficial to the keloid scar in question. In such cases it may be wished to adopt an alternative treatment strategy, and optionally to subsequently assess the effectiveness of the alternative strategy in the same manner.

Table Legends

Genes the expression of which may be investigated in accordance with the present invention are set out in the accompanying Tables. These Tables provide, in respect of each gene, a Gene Identification Number; a Public Identifier and Data Source (by which the skilled person may identify the gene in question and obtain further information regarding its sequence); the Gene Name; a Probe ID (setting out details of at least one probe that may be used to investigate expression of the gene in question); details of tissues that may be used in comparing expression of the gene in question; as well as details of the Fold Change in expression and P value derived from comparisons conducted as described in the Experimental Results section.

Table 1: Genes that diagnose a keloid scar. All genes are highly statistically significant with p-values less than 0.01.

Table 2: Genes that may be used in the diagnosis of a peri-lesional sample of a scar of interest as a keloid or non-keloid scar.

Table 3: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and a normal skin comparator to diagnose the scar of interest as a keloid or non-keloid scar.

Table 4: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and a normal skin comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with cell motility functionality in accordance with the Gene Ontology classification (GO:0006928).

Table 5: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and a normal skin comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with cell adhesion functionality in accordance with the Gene Ontology classification (GO:0007155).

Table 6: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and a normal skin comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with inflammation functionality in accordance with the Gene Ontology classification (GO:0006954).

Table 7: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and a normal skin comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with angiogenesis functionality in accordance with the Gene Ontology classification (GO:0001525).

Table 8: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and an extra-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar.

Table 9: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and an extra-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with cell motility functionality in accordance with the Gene Ontology classification (GO:0006928). Table 10: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and an extra-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with cell adhesion functionality in accordance with the Gene Ontology classification (GO:0007155).

Table 11: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and an extra-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with inflammation functionality in accordance with the Gene Ontology classification (GO:0006954).

Table 12: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and an extra-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with angiogenesis functionality in accordance with the Gene Ontology classification (GO:0001525).

Table 13: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and a peri-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar.

Table 14: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and a peri-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with cell adhesion functionality in accordance with the Gene Ontology classification (GO:0007155).

Table 15: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and a peri-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with inflammation functionality in accordance with the Gene Ontology classification (GO:0006954).

Table 16: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and a peri-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with angiogenesis functionality in accordance with the Gene Ontology classification (GO:0001525).

Table 17: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and an intra-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar.

Table 18: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and an intra-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with cell motility functionality in accordance with the Gene Ontology classification (GO:0006928).

Table 19: Genes the expression of which may be compared between a peri-lesional sample from a scar of interest and an intra-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with inflammation functionality in accordance with the Gene Ontology classification (GO:0006954).

Table 20: Genes that may be used in the diagnosis of an intra-lesional sample of a scar of interest as a keloid or non-keloid scar.

Table 21: Genes the expression of which may be compared between an intra-lesional sample from a scar of interest and a normal skin comparator to diagnose the scar of interest as a keloid or non-keloid scar.

Table 22: Genes the expression of which may be compared between an intra-lesional sample from a scar of interest and an extra-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar.

Table 23: Genes the expression of which may be compared between an intra-lesional sample from a scar of interest and an extra-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with cell motility functionality in accordance with the Gene Ontology classification (GO:0006928).

Table 24: Genes the expression of which may be compared between an intra-lesional sample from a scar of interest and a peri-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar.

Table 25: Genes the expression of which may be compared between an intra-lesional sample from a scar of interest and a peri-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with cell adhesion functionality in accordance with the Gene Ontology classification (GO:00071 55).

Table 26: Genes the expression of which may be compared between an intra-lesional sample from a scar of interest and an intra-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar.

Table 27: Genes the expression of which may be compared between an intra-lesional sample from a scar of interest and an intra-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with inflammation functionality in accordance with the Gene Ontology classification (GO:0006954).

Table 28: Genes the expression of which may be compared between an intra-lesional sample from a scar of interest and an intra-keloid comparator to diagnose the scar of interest as a keloid or non-keloid scar. Genes identified in this table encode proteins with angiogenesis functionality in accordance with the Gene Ontology classification (GO:0001 525).

The invention will now be further described with reference to the following Experimental Results.

EXPERIMENTAL RESULTS

The suitability of the genes set out in Table 1 for use in the diagnosis of scars of interest as keloid or non-keloid is illustrated by the following study. In this study expression of the genes set out in Table 1 was compared between samples taken from known keloid tissues and suitably matched comparator tissues.

1.1 Diagnosis of Keloid Tissue.

Twenty patients of the African Continental Ancestry Group who had keloids that had been established for at least one year provided keloid samples for use in the present study. Only keloids for which a full medical history could be established were included. The age of the scar, a thorough review of the scar history and examination by a clinician, ensured that the scar had been correctly diagnosed as keloidal and not hypertrophic.

Three African Continental Ancestry Group subjects with no history of keloid formation provided control comparator tissue (“normal comparator”) for use in the study described herein.

1.2 Tissue Collection.

Keloids were sampled using ellipsoid excisions perpendicular to the keloid margin and the resulting biopsies were sectioned to provide samples comprising skin surrounding the keloid lesion (extra-keloid tissue), the peripheral portion of the keloid lesion (peri-lesional tissue), or the interior part of the keloid lesion (intra-lesional tissue). Since these tissues were selected from stringently diagnosed examples of keloids they provided a suitable experimental example to test the diagnostic capacity of the genes set out in Table 1.

Extra-keloid tissue collected in these procedures was used as a comparator tissue (extra-keloid comparator) for use in the following studies. Skin tissue from non-keloid forming individuals was also biopsied in a similar manner to provide relevant non-keloid comparator tissues.

Once collected, the biopsy sections were immersed in RNA Later solution (Ambion) and stored at −80° C. until later analysis of gene expression.

1.3 Preparation of Samples Representative of Gene Expression in Tissue.

Peri-lesional, intra-lesional and extra-lesional samples from keloid formers and skin samples from non-keloid formers were disrupted using a Diax (G-10) homogeniser in the presence of proprietary Qiagen lysis buffer, and the lysate produced then incubated with proteinase K at 55° C. for 20 minutes.

Following incubation the mixture was separated by centrifugation, and RNA present purified using a RNeasy midi spin column (Qiagen Ltd).

1.4 Production of Nucleic Acid Targets.

10 μg total RNA was used as substrate for cDNA synthesis using the Superscript System (Invitrogen Corp.). The resulting cDNA was then converted to biotinylated cRNA target molecules using the BioArray RNA Transcript labelling Kit (Enzo Life Sciences Inc.). The cRNA target molecules were subsequently purified from the reaction mixture using a RNeasy mini kit (Qiagen Ltd). 20 μg cRNA was fragmented for array hybridisation.

1.5 Comparison of Gene Expression.

Fragmented cRNA target molecules representative of gene expression in peri- and intra-lesional keloid tissues and in extra-keloid and non-keloid comparator tissues were hybridised to oligonucleotide arrays comprising oligonucleotide probes representing the genes set out in Table 1. Standard Affymetrix protocols (Affymetrix Inc) were used to effect hybridisation. The hybridised arrays were stained with streptavidin-phycoerythrin and then scanned using a laser confocal scanner to generate fluorescence intensities.

All arrays were normalised to a target intensity of 1000, and signal values and detection P-values were calculated using the Microarray Analysis Suite version 5.0 software. Data sets passing quality control were imported into the Spotfire analysis suite for comparison of expression with that in comparator tissues.

Signal values were transformed to log 2 scale and t-tests comparing the gene expression in samples representative of keloids with expression in comparators were performed on the log 2 transformed data. Mean signal values were calculated for each sample group and fold changes were calculated from these mean values.

1.6 Results.

T-tests comparing expression of the genes set out in Table 1 in keloid tissues (peri- and intra-lesional tissues) with expression of the same genes in comparator tissues all had a t-test p-value of less than 0.01. This confirms that the expression of each and all of the genes set out in Table 1 are highly significantly decreased in keloid tissue as opposed to comparators.

These results clearly illustrate that decreased expression in a sample from a scar of interest of one or more genes from the group set out in Table 1, as compared to expression of the same gene or genes in a comparator sample, provides a clear diagnosis that the scar of interest is a keloid tissue.

TABLE 1

Diagnostic Down

Gene ID
Public Identifier
Data Source
Gene Name
Probe_ID
Comparison
Fold Change
P value

1
4250
Entrez Gene
secretoglobin, family 2A, member 2
36329_at
Day 0 Intra/Day 0 Control
0.009
7.1701E−04

36329_at
Day 3 Intra/Day 3 Control
0.017
3.3179E−04

36329_at
Day 7 Intra/Day 7 Control
0.021
2.8985E−03

36329_at
Day 3 Intra/Day 3 Extra
0.023
2.7212E−03

36329_at
Day 3 Peri/Day 3 Control
0.131
2.0793E−03

2
5304
Entrez Gene
prolactin-induced protein
41094_at
Day 0 Intra/Day 0 Control
0.032
5.1676E−04

41094_at
Day 7 Intra/Day 7 Control
0.076
9.5561E−03

41094_at
Day 3 Intra/Day 3 Control
0.094
1.9791E−04

3
10647
Entrez Gene
secretoglobin, family 1D, member 2
32880_at
Day 0 Intra/Day 0 Control
0.033
4.4000E−05

32880_at
Day 7 Intra/Day 7 Control
0.065
7.5456E−03

32880_at
Day 3 Intra/Day 3 Control
0.075
8.2511E−04

32880_at
Day 3 Intra/Day 3 Extra
0.102
5.4085E−03

32880_at
Day 3 Peri/Day 3 Control
0.211
2.5582E−03

4
HG1763-HT178
The Institute for
—
325_s_at
Day 3 Intra/Day 3 Extra
0.038
6.4653E−03

Genomic Research

325_s_at
Day 7 Intra/Day 7 Control
0.060
1.7598E−03

325_s_at
Day 3 Intra/Day 3 Control
0.073
2.6304E−04

325_s_at
Day 0 Intra/Day 0 Control
0.091
6.8631E−04

5
2167
Entrez Gene
fatty acid binding protein 4, adipocyte
38430_at
Day 7 Intra/Day 7 Extra
0.053
1.3371E−03

38430_at
Day 7 Intra/Day 7 Control
0.075
4.2884E−03

38430_at
Day 0 Peri/Day 0 Control
0.219
8.7014E−03

6
3283
Entrez Gene
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
35721_at
Day 0 Intra/Day 0 Peri
0.062
4.4497E−03

7
6288
Entrez Gene
serum amyloid A1
33272_at
Day 3 Intra/Day 3 Extra
0.069
6.8147E−03

33272_at
Day 7 Intra/Day 7 Extra
0.117
4.3324E−03

8
9415
Entrez Gene
fatty acid desaturase 2
32190_at
Day 0 Intra/Day 0 Peri
0.081
5.6381E−04

32190_at
Day 7 Intra/Day 7 Peri
0.201
7.6424E−03

32190_at
Day 3 Peri/Day 0 Peri
0.365
8.5757E−03

9
247
Entrez Gene
arachidonate 15-lipoxygenase, second type
37430_at
Day 0 Intra/Day 0 Peri
0.096
4.5492E−03

10
1690
Entrez Gene
coagulation factor C homolog, cochlin (Limulus polyphemus)
34190_at
Day 3 Intra/Day 3 Extra
0.129
1.6089E−03

11
553168
Entrez Gene
chromosome 1 open reading frame 68
31326_at
Day 7 Peri/Day 7 Control
0.138
7.6909E−03

31326_at
Day 3 Peri/Day 3 Control
0.214
6.7718E−03

31326_at
Day 7 Peri/Day 0 Peri
0.229
1.6500E−05

31326 at
Day 7 Peri/Day 7 Extra
0.288
7.6740E−03

31326_at
Day 3 Peri/Day 0 Peri
0.487
3.0725E−03

12
HG371-HT2638
The Institute for
—
700_s_at
Day 0 Intra/Day 0 Peri
0.143
4.4849E−03

Genomic Research

13
125
Entrez Gene
alcohol dehydrogenase IB (class I), beta polypeptide
35730_at
Day 3 Intra/Day 0 Intra
0.162
9.2302E−03

35730_at
Day 0 Peri/Day 0 Intra
0.252
5.3255E−03

14
3205
Entrez Gene
homeo box A9
37809_at
Day 3 Peri/Day 3 Control
0.180
5.0202E−03

37809_at
Day 7 Peri/Day 7 Extra
0.237
8.7426E−03

37809_at
Day 3 Peri/Day 3 Extra
0.314
9.1991E−03

15
7136
Entrez Gene
troponin I type 2 (skeletal, fast)
38457_at
Day 0 Peri/Day 0 Control
0.185
5.1425E−04

16
L09190
GenBank
Full-length cDNA clone CS0DI027YJ05 of Placenta Cot
37635_at
Day 3 Intra/Day 3 Peri
0.206
2.8404E−03

25-normalized at Homo sapiens (human)

17
6210
Entrez Gene
ribosomal protein S15a
34316_at
Day 3 Peri/Day 3 Control
0.241
3.8100E−05

34316_at
Day 7 Peri/Day 7 Control
0.432
2.3230E−04

34316_at
Day 3 Peri/Day 3 Extra
0.476
1.6785E−04

18
7123
Entrez Gene
C-type lectin domain family 3, member B
36569_at
Day 3 Intra/Day 0 Intra
0.243
7.7786E−03

36569_at
Day 3 Peri/Day 0 Peri
0.356
1.8400E−05

36569_at
Day 7 Peri/Day 0 Peri
0.428
5.8746E−04

19
10351
Entrez Gene
ATP-binding cassette, sub-family A (ABC1), member 8
35717_at
Day 3 Intra/Day 0 Intra
0.279
3.1166E−03

35717_at
Day 3 Intra/Day 3 Peri
0.305
5.8783E−04

20
AB011538
GenBank
CDNA clone IMAGE: 5922621
35324_at
Day 3 Intra/Day 0 Intra
0.280
3.8006E−03

35324_at
Day 3 Peri/Day 0 Peri
0.447
1.3446E−04

35324_at
Day 7 Peri/Day 0 Peri
0.623
4.2479E−03

21
3131
Entrez Gene
Hepatic leukemia factor
38627_at
Day 3 Intra/Day 0 Intra
0.289
1.1838E−03

38627_at
Day 7 Intra/Day 0 Intra
0.325
6.7101E−03

38627_at
Day 0 Peri/Day 0 Intra
0.556
5.7849E−03

22
M57951
GenBank
UDP glucuronosyltransferase 1 family, polypeptide A10
32392_s_at
Day 3 Peri/Day 3 Extra
0.320
3.1014E−03

/// UDP glucuronosyltransferase 1 family, polypeptide

A8 /// UDP glucuronosyltransferase 1 fami

23
4211
Entrez Gene
Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)
40763_at
Day 3 Intra/Day 0 Intra
0.324
4.5206E−03

24
2053
Entrez Gene
epoxide hydrolase 2, cytoplasmic
41473_at
Day 3 Intra/Day 0 Intra
0.327
3.5922E−03

41473_at
Day 3 Peri/Day 0 Peri
0.521
6.6949E−03

25
4253
Entrez Gene
CTAGE family, member 5
41615_at
Day 3 Intra/Day 0 Intra
0.330
3.8948E−03

26
5271
Entrez Gene
serpin peptidase inhibitor, clade B (ovalbumin), member 8
36312_at
Day 7 Peri/Day 7 Extra
0.331
4.7432E−04

36312_at
Day 7 Intra/Day 7 Extra
0.482
4.6083E−03

27
3119
Entrez Gene
major histocompatibility complex, class II, DQ beta 1
36876_f_at
Day 0 Intra/Day 0 Control
0.350
9.9683E−03

28
10781
Entrez Gene
zinc finger protein 266
41621_i_at
Day 0 Peri/Day 0 Control
0.350
5.4116E−04

29
4128
Entrez Gene
monoamine oxidase A
41772_at
Day 3 Peri/Day 3 Extra
0.351
3.2109E−03

41771_g_at
Day 3 Peri/Day 3 Control
0.464
2.4030E−03

41772_at
Day 7 Peri/Day 7 Extra
0.614
6.2007E−03

30
3885
Entrez Gene
keratin, hair, acidic, 4
34012_at
Day 0 Intra/Day 0 Peri
0.352
4.5590E−03

31
8483
Entrez Gene
cartilage intermediate layer protein, nucleotide
34985_at
Day 3 Peri/Day 0 Peri
0.354
4.8214E−04

pyrophosphohydrolase
34985_at
Day 7 Peri/Day 0 Peri
0.381
2.9109E−03

32
11075
Entrez Gene
stathmin-like 2
38800_at
Day 3 Intra/Day 0 Intra
0.356
5.6882E−03

33
3075
Entrez Gene
complement factor H
32250_at
Day 7 Intra/Day 0 Intra
0.356
2.4648E−03

34
10458
Entrez Gene
BAl1-associated protein 2
37761_at
Day 7 Peri/Day 0 Peri
0.358
3.2292E−04

37760_at
Day 7 Intra/Day 3 Intra
0.799
8.1747E−03

35
9086
Entrez Gene
eukaryotic translation initiation factor 1A, Y-linked
40097_at
Day 3 Intra/Day 0 Intra
0.358
8.6154E−03

36
2273
Entrez Gene
four and a half LIM domains 1
32542_at
Day 3 Intra/Day 0 Intra
0.367
5.7500E−03

32542_at
Day 3 Peri/Day 0 Peri
0.598
1.0604E−03

32542_at
Day 7 Peri/Day 0 Peri
0.643
1.4304E−03

37
23016
Entrez Gene
exosome component 7
33294_at
Day 0 Peri/Day 0 Control
0.369
2.9368E−04

33294_at
Day 3 Peri/Day 3 Control
0.453
3.7416E−04

38
23352
Entrez Gene
retinoblastoma-associated factor 600
33860_at
Day 0 Peri/Day 0 Control
0.369
5.2550E−04

33860_at
Day 3 Peri/Day 3 Control
0.374
1.4026E−03

33860_at
Day 7 Peri/Day 7 Control
0.452
4.0374E−03

33860_at
Day 3 Peri/Day 3 Extra
0.549
6.8632E−03

33860_at
Day 7 Peri/Day 7 Extra
0.579
3.6353E−03

39
7138
Entrez Gene
troponin T type 1 (skeletal, slow)
36113_s_at
Day 7 Peri/Day 7 Control
0.371
6.4628E−03

36113_s_at
Day 3 Peri/Day 3 Control
0.452
4.3070E−03

40
4223
Entrez Gene
mesenchyme homeo box 2 (growth arrest-specific
40398_s_at
Day 3 Intra/Day 0 Intra
0.376
7.2046E−03

homeo box)

41
3400
Entrez Gene
Inhibitor of DNA binding 4, dominant negative helix-loop
41536_at
Day 3 Intra/Day 0 Intra
0.381
8.0900E−05

helix protein
41536_at
Day 7 Intra/Day 0 Intra
0.410
2.1354E−03

41536_at
Day 3 Intra/Day 3 Control
0.488
2.0560E−03

42
10521
Entrez Gene
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
35363_at
Day 0 Peri/Day 0 Control
0.383
2.2472E−03

35363_at
Day 7 Peri/Day 7 Extra
0.577
6.8649E−03

43
8710
Entrez Gene
serpin peptidase inhibitor, clade B (ovalbumin), member 7
35577_at
Day 0 Peri/Day 0 Control
0.385
4.8105E−04

35577_at
Day 0 Intra/Day 0 Control
0.489
6.7433E−03

35577_at
Day 3 Intra/Day 3 Control
0.566
9.3574E−03

44
2194
Entrez Gene
fatty acid synthase
38429_at
Day 0 Intra/Day 0 Peri
0.386
9.3714E−03

38429_at
Day 3 Peri/Day 0 Peri
0.512
8.4627E−03

45
3202
Entrez Gene
homeo box A5
873_at
Day 3 Peri/Day 3 Extra
0.387
6.1920E−03

46
54
Entrez Gene
acid phosphatase 5, tartrate resistant
677_s_at
Day 7 Peri/Day 7 Control
0.389
2.8442E−04

677_s_at
Day 7 Peri/Day 7 Extra
0.672
8.0184E−03

47
406
Entrez Gene
aryl hydrocarbon receptor nuclear translocator-like
36896_s_at
Day 3 Intra/Day 3 Control
0.391
9.1974E−03

48
9452
Entrez Gene
Integral membrane protein 2A
40775_at
Day 3 Intra/Day 0 Intra
0.392
3.3491E−03

40775_at
Day 7 Intra/Day 0 Intra
0.400
2.0273E−03

49
63928
Entrez Gene
hepatocellular carcinoma antigen gene 520
33007_at
Day 3 Peri/Day 3 Control
0.394
7.4079E−03

33007_at
Day 3 Intra/Day 3 Control
0.466
7.7206E−03

50
5055
Entrez Gene
serpin peptidase inhibitor, clade B (ovalbumin), member 2
37185_at
Day 0 Peri/Day 0 Control
0.399
5.5226E−03

51
5354
Entrez Gene
proteolipid protein 1 (Pelizaeus-Merzbacher disease,
41158_at
Day 3 Intra/Day 0 Intra
0.403
1.1357E−04

spastic paraplegia 2, uncomplicated)
41158_at
Day 7 Intra/Day 0 Intra
0.503
1.7500E−03

41158_at
Day 0 Peri/Day 0 Control
0.544
4.8737E−03

41158_at
Day 3 Peri/Day 0 Peri
0.715
7.5707E−03

52
642
Entrez Gene
bleomycin hydrolase
394_at
Day 3 Peri/Day 3 Control
0.404
6.8138E−03

53
10443
Entrez Gene
Hypothetical gene CG012
1532_g_at
Day 0 Peri/Day 0 Control
0.406
9.9594E−04

1532_g_at
Day 3 Peri/Day 3 Control
0.567
4.1852E−03

1532_g_at
Day 0 Peri/Day 0 Intra
0.660
5.2680E−03

54
224
Entrez Gene
aldehyde dehydrogenase 3 family, member A2
40409_at
Day 3 Intra/Day 3 Control
0.410
5.0007E−03

40409_at
Day 3 Peri/Day 3 Control
0.445
7.4233E−03

40409_at
Day 3 Intra/Day 0 Intra
0.466
8.5061E−04

55
90634
Entrez Gene
hypothetical gene CG018
1527_s_at
Day 0 Peri/Day 0 Control
0.410
2.0450E−03

34239_at
Day 3 Intra/Day 3 Control
0.472
5.9625E−03

1527_s_at
Day 3 Peri/Day 3 Control
0.515
2.5140E−03

56
1675
Entrez Gene
D component of complement (adipsin)
40282_s_at
Day 7 Peri/Day 0 Peri
0.410
3.2238E−03

57
23242
Entrez Gene
cordon-bleu homolog (mouse)
35669_at
Day 3 Intra/Day 0 Intra
0.414
5.3389E−03

35669_at
Day 3 Intra/Day 3 Control
0.417
3.3977E−03

35669_at
Day 3 Intra/Day 3 Extra
0.522
4.0595E−04

35669_at
Day 7 Peri/Day 0 Peri
0.543
1.1342E−03

35669_at
Day 3 Peri/Day 0 Peri
0.585
1.2820E−03

58
10158
Entrez Gene
PDZK1 interacting protein 1
31610_at
Day 3 Peri/Day 3 Extra
0.421
4.1131E−03

59
10001
Entrez Gene
mediator of RNA polymerase II transcription, subunit 6 homolog (yeast)
35430_at
Day 3 Peri/Day 3 Control
0.427
4.0549E−03

60
97
Entrez Gene
acylphosphatase 1, erythrocyte (common) type
33334_at
Day 0 Peri/Day 0 Control
0.427
3.3326E−03

61
M11119
GenBank
—
38850_at
Day 3 Intra/Day 0 Intra
0.428
8.8745E−03

62
9687
Entrez Gene
GREB1 protein
38875_r_at
Day 7 Intra/Day 0 Intra
0.428
1.0961E−04

63
51097
Entrez Gene
saccharopine dehydrogenase (putative)
34863_s_at
Day 3 Peri/Day 3 Control
0.430
9.0435E−03

34862_at
Day 7 Intra/Day 0 Intra
0.680
6.5823E−03

64
2217
Entrez Gene
Fc fragment of IgG, receptor, transporter, alpha
31431_at
Day 7 Peri/Day 7 Control
0.430
7.9132E−04

65
1983
Entrez Gene
eukaryotic translation initiation factor 5
167_at
Day 3 Peri/Day 3 Control
0.431
3.2376E−04

167_at
Day 7 Peri/Day 7 Extra
0.519
7.0199E−03

66
51601
Entrez Gene
lipoyltransferase 1
37441_at
Day 0 Peri/Day 0 Intra
0.432
3.4529E−03

67
9145
Entrez Gene
synaptogyrin 1
35354_at
Day 7 Intra/Day 0 Intra
0.432
1.9735E−03

35354_at
Day 3 Intra/Day 0 Intra
0.469
5.7597E−03

68
1117
Entrez Gene
chitinase 3-like 2
31891_at
Day 0 Intra/Day 0 Peri
0.432
5.3219E−04

69
13
Entrez Gene
arylacetamide deacetylase (esterase)
36512_at
Day 3 Intra/Day 3 Extra
0.434
1.5905E−04

70
2618
Entrez Gene
phosphoribosylglycinamide formyltransferase,
38384_at
Day 3 Peri/Day 3 Extra
0.436
8.9104E−03

phosphoribosylglycinamide synthetase,

phosphoribosylaminoimidazole synthetase

71
HG3570-HT377
The Institute for
—
936_s_at
Day 3 Peri/Day 3 Control
0.437
1.3929E−04

Genomic Research

936_s_at
Day 7 Peri/Day 7 Control
0.554
6.0851E−03

936_s_at
Day 7 Peri/Day 0 Peri
0.679
6.6192E−03

72
53335
Entrez Gene
B-cell CLL/lymphoma 11A (zinc finger protein)
41356_at
Day 3 Peri/Day 3 Extra
0.438
5.3163E−03

73
57798
Entrez Gene
GATA zinc finger domain containing 1
34195_at
Day 3 Intra/Day 3 Peri
0.441
6.2766E−04

74
8906
Entrez Gene
adaptor-related protein complex 1, gamma 2 subunit
38798_s_at
Day 0 Peri/Day 0 Control
0.441
6.9369E−03

38798_s_at
Day 3 Peri/Day 3 Control
0.480
6.4090E−03

75
26
Entrez Gene
amiloride binding protein 1 (amine oxidase (copper-
37186_s_at
Day 3 Intra/Day 3 Extra
0.443
5.1668E−03

containing))

76
AL080082
GenBank
MRNA; cDNA DKFZp564G1162 (from clone
35581_at
Day 3 Intra/Day 0 Intra
0.444
9.2254E−03

DKFZp564G1162)

77
9524
Entrez Gene
glycoprotein, synaptic 2
38966_at
Day 7 Peri/Day 7 Control
0.444
3.9851E−03

38966_at
Day 3 Peri/Day 3 Control
0.530
1.4148E−03

38966_at
Day 7 Peri/Day 0 Peri
0.614
2.1060E−03

78
91137
Entrez Gene
hypothetical protein BC017169
37178_at
Day 3 Peri/Day 3 Control
0.449
3.9314E−03

79
56288
Entrez Gene
par-3 partitioning defective 3 homolog (C. elegans)
40973_at
Day 0 Peri/Day 0 Control
0.451
2.5568E−03

40973_at
Day 3 Intra/Day 3 Control
0.533
5.0405E−03

80
26154
Entrez Gene
ATP-binding cassette, sub-family A (ABC1), member 12
31754_at
Day 3 Peri/Day 3 Extra
0.453
4.6700E−03

31754_at
Day 3 Intra/Day 3 Extra
0.557
5.7474E−03

81
260294
Entrez Gene
Williams Beuren syndrome chromosome region 20C
41258_at
Day 0 Peri/Day 0 Control
0.453
3.7268E−03

82
1410
Entrez Gene
crystallin, alpha B
32242_at
Day 3 Peri/Day 3 Extra
0.454
8.8596E−03

32243_g_at
Day 3 Intra/Day 3 Extra
0.468
5.9480E−03

83
131544
Entrez Gene
hypothetical protein DKFZp667G2110
41274_at
Day 0 Peri/Day 0 Control
0.454
4.4963E−03

41274_at
Days 3 Peri/Day 3 Control
0.589
7.6530E−03

84
10733
Entrez Gene
polo-like kinase 4 (Drosophila)
975_at
Day 7 Intra/Day 7 Extra
0.455
5.4588E−03

975_at
Day 7 Peri/Day 7 Extra
0.459
4.3469E−03

85
8848
Entrez Gene
TSC22 domain family, member 1
39032_at
Day 3 Intra/Day 0 Intra
0.455
1.8273E−03

86
10181
Entrez Gene
RNA binding motif protein 5
1556_at
Day 0 Peri/Day 0 Control
0.460
1.4047E−03

87
5264
Entrez Gene
phytanoyl-CoA hydroxylase (Refsum disease)
32724_at
Day 3 Intra/Day 0 Intra
0.465
4.1244E−03

88
10529
Entrez Gene
nebulette
34873_at
Day 3 Intra/Day 3 Control
0.466
5.5136E−03

89
60481
Entrez Gene
ELOVL family member 5, elongation of long chain fatty
33821_at
Day 0 Intra/Day 0 Peri
0.468
8.7794E−03

acids (FEN1/Elo2, SUR4/Elo3-like, yeast)

90
6924
Entrez Gene
Transcription elongation factor B (SIII), polypeptide 3
32049_f_at
Day 0 Peri/Day 0 Intra
0.469
3.1906E−03

(110 kDa, elongin A)

91
10248
Entrez Gene
processing of precursor 7, ribonuclease P subunit (S. cerevisiae)
32213_at
Day 7 Intra/Day 3 Intra
0.470
9.0083E−03

92
1545
Entrez Gene
cytochrome P450, family 1, subfamily B, polypeptide 1
40071_at
Day 7 Intra/Day 7 Peri
0.471
9.8480E−03

93
1152
Entrez Gene
creatine kinase, brain
40863_r_at
Day 7 Intra/Day 7 Control
0.472
4.0142E−03

40863_r_at
Day 7 Peri/Day 0 Peri
0.507
3.2271E−04

94
10450
Entrez Gene
peptidylprolyl isomerase E (cyclophilin E)
34365_at
Day 3 Peri/Day 3 Control
0.473
5.7231E−03

34365_at
Day 3 Intra/Day 3 Control
0.518
4.1270E−03

34365_at
Day 7 Peri/Day 0 Peri
0.638
2.8273E−03

95
HG1112-HT111
The Institute for
—
1839_at
Day 3 Peri/Day 3 Extra
0.473
1.6274E−03

Genomic Research

1839_at
Day 3 Peri/Day 3 Control
0.555
9.8116E−03

96
10090
Entrez Gene
uronyl-2-sulfotransferase
41859_at
Day 3 Intra/Day 0 Intra
0.474
1.8927E−03

41859_at
Day 7 Intra/Day 0 Intra
0.521
1.4198E−04

97
4129
Entrez Gene
monoamine oxidase B
37628_at
Day 3 Peri/Day 3 Extra
0.475
8.4099E−04

98
352961
Entrez Gene
MHC class I mRNA fragment 3.8-1
34934_at
Day 3 Intra/Day 0 Intra
0.479
6.5297E−03

99
10314
Entrez Gene
LanC lantibiotic synthetase component C-like 1
39441_at
Day 0 Peri/Day 0 Control
0.482
2.7594E−03

(bacterial)
39441_at
Day 0 Intra/Day 0 Control
0.488
6.0119E−04

100
10628
Entrez Gene
thioredoxin interacting protein
31508_at
Day 3 Intra/Day 0 Intra
0.482
9.0159E−03

101
8532
Entrez Gene
carboxypeptidase Z
37248_at
Day 7 Peri/Day 0 Peri
0.483
2.2125E−04

37248_at
Day 3 Peri/Day 0 Peri
0.522
7.1260E−04

102
6038
Entrez Gene
ribonuclease, RNase A family, 4
32664_at
Day 3 Intra/Day 0 Intra
0.483
2.7472E−03

32664_at
Day 7 Intra/Day 0 Intra
0.569
4.9291E−03

32664_at
Day 3 Peri/Day 0 Peri
0.636
5.8524E−04

32664_at
Day 7 Peri/Day 0 Peri
0.691
3.6796E−03

103
10924
Entrez Gene
sphingomyelin phosphodiesterase, acid-like 3A
39950_at
Day 3 Peri/Day 3 Control
0.483
8.6125E−03

104
6414
Entrez Gene
selenoprotein P, plasma, 1
34363_at
Day 3 Intra/Day 0 Intra
0.488
6.0330E−03

105
9987
Entrez Gene
Heterogeneous nuclear ribonucleoproteln D-like
32393_s_at
Day 3 Intra/Day 3 Peri
0.489
1.9407E−03

106
8634
Entrez Gene
RNA terminal phosphate cyclase domain 1
35195_at
Day 7 Peri/Day 7 Extra
0.489
1.6326E−03

107
4163
Entrez Gene
mutated in colorectal cancers
35561_at
Day 0 Intra/Day 0 Peri
0.489
6.2800E−05

35561_at
Day 7 Peri/Day 0 Peri
0.606
7.2171E−03

108
7262
Entrez Gene
pleckstrin homology-like domain, family A, member 2
31888_s_at
Day 3 Peri/Day 3 Extra
0.490
4.0424E−03

109
26039
Entrez Gene
synovial sarcoma translocation gene on chromosome
31903_at
Day 0 Peri/Day 0 Control
0.493
1.3274E−03

18-like 1

110
1525
Entrez Gene
coxsackie virus and adenovirus receptor
37534_at
Day 3 Peri/Day 3 Extra
0.493
7.3178E−03

111
2947
Entrez Gene
glutathione S-transferase M3 (brain)
1120_at
Day 7 Intra/Day 0 Intra
0.494
7.1503E−03

112
11072
Entrez Gene
dual specificity phosphatase 14
38272_at
Day 7 Peri/Day 7 Extra
0.494
1.4839E−03

113
6490
Entrez Gene
silver homolog (mouse)
38327_at
Day 3 Peri/Day 3 Extra
0.497
4.4983E−04

38327_at
Day 3 Peri/Day 3 Control
0.512
5.3933E−04

38327_at
Day 3 Peri/Day 0 Peri
0.710
9.2062E−03

114
8864
Entrez Gene
period homolog 2 (Drosophila)
35008_at
Day 3 Intra/Day 0 Intra
0.497
4.3990E−03

115
4176
Entrez Gene
MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
947_at
Day 0 Peri/Day 0 Control
0.498
7.8436E−04

116
2197
Entrez Gene
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV)
31955_at
Day 7 Peri/Day 7 Control
0.498
8.3003E−03

ubiquitously expressed (fox derived); ribosomal protein

S30

117
104
Entrez Gene
adenosine deaminase, RNA-specific, B1 (RED1
38748_at
Day 3 Intra/Day 0 Intra
0.499
8.5077E−04

homolog rat)
38748_at
Day 7 Intra/Day 0 Intra
0.541
1.9004E−03

118
4898
Entrez Gene
nardilysin (N-arginine dibasic convertase)
34787_at
Day 3 Peri/Day 3 Control
0.499
2.6275E−03

119
6662
Entrez Gene
SRY (sex determining region Y)-box 9 (campomelic
33436_at
Day 3 Peri/Day 3 Extra
0.500
5.3219E−03

dysplasia, autosomal sex-reversal)
33436_at
Day 0 Intra/Day 0 Peri
0.521
8.5777E−03

120
2114
Entrez Gene
v-ets erythroblastosis virus E26 oncogene homolog 2
38739_at
Day 3 Peri/Day 3 Extra
0.501
4.4662E−03

(avian)

121
1158
Entrez Gene
creatine kinase, muscle
32486_at
Day 0 Peri/Day 0 Intra
0.501
6.1425E−03

122
9831
Entrez Gene
zinc finger protein 623
39954_r_at
Day 3 Intra/Day 0 Intra
0.505
3.3609E−03

123
1573
Entrez Gene
cytochrome P450, family 2, subfamily J, polypeptide 2
501_g_at
Day 3 Peri/Day 3 Control
0.505
2.0051E−03

501_g_at
Day 3 Intra/Day 3 Control
0.529
4.2791E−03

124
22982
Entrez Gene
KIAA0934
33408_at
Day 3 Intra/Day 0 Intra
0.506
3.1621E−03

125
51710
Entrez Gene
zinc finger protein 44 (KOX7)
35409_r_at
Day 3 Intra/Day 3 Peri
0.507
5.1572E−03

126
2533
Entrez Gene
FYN binding protein (FYB-120/130)
41819_at
Day 3 Intra/Day 3 Peri
0.507
3.0115E−03

127
9857
Entrez Gene
centrosome-associated protein 350
33805_at
Day 3 Intra/Day 3 Peri
0.508
4.3400E−05

128
9891
Entrez Gene
NUAK family, SNF1-like kinase, 1
33787_at
Day 3 Intra/Day 0 Intra
0.508
1.4528E−03

129
9833
Entrez Gene
maternal embryonic leucine zipper kinase
38847_at
Day 7 Peri/Day 7 Extra
0.510
9.6404E−03

130
U18300
GenBank
damage-specific DNA binding protein 2, 48 kDa /// LIM
1243_at
Day 3 Peri/Day 3 Control
0.511
4.6848E−04

homeobox 3
1243_at
Day 0 Peri/Day 0 Control
0.556
6.7443E−03

1243_at
Day 7 Peri/Day 0 Peri
0.749
8.6022E−03

131
23051
Entrez Gene
zinc fingers and homeoboxes 3
40461_at
Day 3 Intra/Day 0 Intra
0.513
6.7006E−04

40461_at
Day 7 Intra/Day 0 Intra
0.609
6.3269E−03

40461_at
Day 3 Peri/Day 0 Peri
0.738
3.2244E−03

132
51706
Entrez Gene
cytochrome b5 reductase 1
35329_at
Day 3 Peri/Day 3 Control
0.513
1.8894E−03

133
3422
Entrez Gene
isopentenyl-diphosphate delta isomerase 1
36985_at
Day 7 Intra/Day 7 Extra
0.515
5.4407E−03

134
7728
Entrez Gene
zinc finger protein 175
37500_at
Day 7 Intra/Day 7 Peri
0.515
4.1955E−03

135
36
Entrez Gene
acyl-Coenzyme A dehydrogenase, short/branched chain
40673_at
Day 3 Intra/Day 3 Control
0.515
1.3679E−03

136
2013
Entrez Gene
epithelial membrane protein 2
39631_at
Day 3 Peri/Day 3 Extra
0.517
3.1103E−03

39631_at
Day 7 Peri/Day 0 Peri
0.629
5.1967E−04

137
81563
Entrez Gene
chromosome 1 open reading frame 21
41679_at
Day 7 Peri/Day 0 Peri
0.517
12344E−03

41679_at
Day 3 Peri/Day 0 Peri
0.607
8.6951E−03

138
1638
Entrez Gene
dopachrome tautomerase (dopachrome delta-
41182_at
Day 7 Peri/Day 0 Peri
0.518
2.7300E−05

isomerase, tyrosine-related protein 2)
41182_at
Day 3 Peri/Day 0 Peri
0.596
1.9071E−04

139
10965
Entrez Gene
acyl-CoA thioesterase 2
36625_at
Day 7 Intra/Day 7 Control
0.518
7.3351E−04

140
10284
Entrez Gene
Sin3-associated polypeptide, 18 kDa
41277_at
Day 3 Intra/Day 0 Intra
0.520
2.4318E−03

141
57613
Entrez Gene
KIAA1467 protein
41826_at
Day 0 Peri/Day 0 Control
0.520
5.9359E−03

142
2647
Entrez Gene
biogenesis of lysosome-related organelles complex-1,
39133_at
Day 7 Peri/Day 7 Control
0.520
1.5729E−03

subunit 1

143
7073
Entrez Gene
TIA1 cytotoxic granule-associated RNA binding protein-
41761_at
Day 3 Intra/Day 0 Intra
0.521
4.5836E−03

like 1

144
AF096870
GenBank
tripartite motif-containing 16 /// similar to tripartite motif-
38881_i_at
Day 3 Peri/Day 3 Extra
0.521
1.0549E−04

containing 16; estrogen-responsive B box protein

145
8853
Entrez Gene
development and differentiation enhancing factor 2
39410_at
Day 7 Intra/Day 0 Intra
0.521
2.9990E−03

146
4968
Entrez Gene
8-oxoguanine DNA glycosylase
38335_at
Day 3 Intra/Day 0 Intra
0.522
7.5868E−04

38335_at
Day 7 Intra/Day 0 Intra
0.626
6.6349E−03

38335_at
Day 0 Peri/Day 0 Intra
0.759
8.2179E−03

147
2110
Entrez Gene
electron-transferring-flavoprotein dehydrogenase
33494_at
Day 7 Intra/Day 7 Extra
0.523
1.1689E−03

148
4713
Entrez Gene
NADH dehydrogenase (ubiquinone) 1 beta subcomplex,
35773_i_at
Day 7 Peri/Day 7 Control
0.525
1.8840E−03

7, 18 kDa
35773_i_at Day
7 Peri/Day 0 Peri
0.748
5.4735E−03

35774_r_at
Day 7 Peri/Day 3 Peri
0.791
1.2591E−03

149
1396
Entrez Gene
cysteine-rich protein 1 (intestinal)
33232_at
Day 7 Peri/Day 0 Peri
0.526
3.2907E−04

33232_at
Day 3 Peri/Day 0 Peri
0.596
1.5417E−03

150
771
Entrez Gene
carbonic anhydrase XII
36454_at
Day 0 Peri/Day 0 Control
0.526
3.3461E−03

35275_at
Day 3 Peri/Day 3 Extra
0.650
2.8445E−03

151
55187
Entrez Gene
vacuolar protein sorting 13D (yeast)
32743_at
Day 3 Intra/Day 0 Intra
0.527
2.5585E−03

32743_at
Day 0 Peri/Day 0 Control
0.619
1.5268E−03

32743_at
Day 3 Peri/Day 0 Peri
0.772
6.0079E−03

152
498
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F1
40096_at
Day 3 Peri/Day 3 Control
0.527
6.5302E−03

complex, alpha subunit, isoform 1, cardiac muscle
40096_at
Day 0 Peri/Day 0 Control
0.563
2.0338E−04

153
9140
Entrez Gene
ATG12 autophagy related 12 homolog (S. cerevisiae)
32720_at
Day 3 Intra/Day 3 Peri
0.530
2.7861E−04

154
242
Entrez Gene
arachidonate 12-lipoxygenase, 12R type
33029_at
Day 7 Peri/Day 7 Extra
0.530
9.3336E−03

155
23506
Entrez Gene
KIAA0240
38892_at
Day 3 Intra/Day 0 Intra
0.531
5.3954E−03

156
5985
Entrez Gene
replication factor C (activator 1) 5, 36.5 kDa
653_at
Day 0 Peri/Day 0 Control
0.533
6.1850E−03

157
26610
Entrez Gene
elongation protein 4 homolog (S. cerevisiae)
38347_at
Day 0 Peri/Day 0 Intra
0.533
6.3391E−03

158
6595
Entrez Gene
SWI/SNF related, matrix associated, actin dependent
40961_at
Day 3 Intra/Day 0 Intra
0.533
6.2437E−03

regulator of chromatin, subfamily a, member 2

159
5110
Entrez Gene
Protein-L-isoaspartate (D-aspartate) O-
37737_at
Day 7 Intra/Day 7 Extra
0.534
2.8151E−03

methyltransferase
37738_g_at
Day 3 Peri/Day 3 Control
0.678
3.6789E−03

160
113146
Entrez Gene
chromosome 14 open reading frame 78
36497_at
Day 3 Peri/Day 3 Control
0.535
3.4244E−03

36497_at
Day 7 Peri/Day 0 Peri
0.545
2.9700E−05

36497_at
Day 3 Peri/Day 0 Peri
0.577
3.7100E−05

161
201229
Entrez Gene
hypothetical protein LOC201229
39557_at
Day 3 Intra/Day 0 Intra
0.535
2.3943E−03

162
22909
Entrez Gene
KIAA1018 protein
36458_at
Day 3 Intra/Day 0 Intra
0.536
6.1234E−03

163
51099
Entrez Gene
Abhydrolase domain containing 5
33309_at
Day 3 Intra/Day 3 Peri
0.536
9.8735E−03

164
114882
Entrez Gene
oxysterol binding protein-like 8
41438_at
Day 3 Intra/Day 3 Peri
0.536
3.0621E−03

165
10124
Entrez Gene
ADP-ribosylation factor-like 4
33796_at
Day 3 Peri/Day 3 Control
0.537
6.8833E−03

166
10653
Entrez Gene
serine peptidase inhibitor, Kunliz type, 2
34348_at
Day 3 Peri/Day 3 Control
0.537
9.4449E−03

34348_at
Day 0 Peri/Day 0 Control
0.573
7.9326E−03

34348_at
Day 7 Intra/Day 7 Extra
0.699
5.3002E−03

167
10434
Entrez Gene
lysophospholipase I
39396_at
Day 3 Peri/Day 3 Control
0.541
7.9687E−03

168
399563
Entrez Gene
hypothetical protein FLJ43806
37151_at
Day 7 Intra/Day 0 Intra
0.542
7.7014E−03

169
123
Entrez Gene
adipose differentiation-related protein
34378_at
Day 7 Peri/Day 7 Extra
0.542
1.2411E−03

170
80308
Entrez Gene
Fad1, flavin adenine dinucleotide synthetase, homolog
39074_at
Day 3 Peri/Day 3 Control
0.544
3.5087E−04

(yeast)

171
1662
Entrez Gene
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
831_at
Day 7 Intra/Day 7 Extra
0.544
5.2360E−03

172
5130
Entrez Gene
phosphate cytidylyltransferase 1, choline, alpha
39285_at
Day 0 Intra/Day 0 Peri
0.545
2.3355E−03

173
23345
Entrez Gene
spectrin repeat containing, nuclear envelope 1
38113_at
Day 0 Peri/Day 0 Control
0.546
1.8607E−03

174
26235
Entrez Gene
F-box and leucine-rich repeat protein 4
39987_at
Day 7 Intra/Day 7 Peri
0.546
3.2958E−03

175
80208
Entrez Gene
hypothetical protein FLJ21439
40615_at
Day 0 Peri/Day 0 Control
0.546
5.1650E−03

176
202
Entrez Gene
absent in melanoma 1
32112_s_at
Day 3 Peri/Day 3 Extra
0.547
1.9891E−03

32112_s_at
Day 3 Intra/Day 3 Extra
0.617
9.6499E−03

177
9774
Entrez Gene
BCL2-associated transcription factor 1
38050_at
Day 7 Intra/Day 7 Extra
0.547
4.7061E−03

178
5268
Entrez Gene
serpin peptidase inhibitor, clade B (ovalbumin), member 5
862_at
Day 3 Peri/Day 3 Extra
0.548
8.5245E−03

862_at
Day 7 Peri/Day 7 Extra
0.576
5.9941E−03

179
1474
Entrez Gene
cystatin E/M
33128_s_at
Day 7 Peri/Day 0 Peri
0.549
1.9072E−03

33128_s_at
Day 3 Peri/Day 0 Peri
0.605
2.6588E−03

180
9927
Entrez Gene
mitofusin 2
34369_at
Day 3 Peri/Day 3 Control
0.549
2.5016E−03

34369_at
Day 3 Peri/Day 3 Extra
0.635
6.4361E−03

181
4232
Entrez Gene
mesoderm specific transcript homolog (mouse)
37749_at
Day 7 Intra/Day 7 Extra
0.553
9.8929E−04

182
2145
Entrez Gene
enhancer of zeste homolog 1 (Drosophila)
32259_at
Day 7 Intra/Day 0 Intra
0.554
8.0450E−03

32259_at
Day 3 Peri/Day 3 Control
0.593
1.0957E−03

183
2959
Entrez Gene
general transcription factor IIB
1070_at
Day 3 Peri/Day 3 Control
0.556
4.5246E−03

184
U73737
GenBank
—
1017_at
Day 3 Intra/Day 3 Peri
0.556
4.6650E−03

185
4736
Entrez Gene
ribosomal protein L10a
36786_at
Day 3 Peri/Day 3 Extra
0.556
7.2273E−04

36786_at
Day 7 Peri/Day 7 Control
0.592
1.4203E−03

36786_at
Day 3 Peri/Day 3 Control
0.622
8.0958E−04

36786_at
Day 0 Peri/Day 0 Control
0.668
3.0374E−03

36786_at
Day 7 Peri/Day 0 Peri
0.783
1.0376E−03

186
644
Entrez Gene
biliverdin reductase A
32618_at
Day 3 Peri/Day 3 Control
0.557
3.0605E−04

32618_at
Day 3 Peri/Day 3 Extra
0.620
3.2950E−04

32618_at
Day 0 Peri/Day 0 Control
0.677
7.9770E−03

32618_at
Day 3 Peri/Day 3 Intra
0.702
5.1159E−03

187
9665
Entrez Gene
limkain b1
31936_s_at
Day 3 Peri/Day 3 Control
0.558
3.7112E−03

188
3033
Entrez Gene
L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain
35435_s_at
Day 3 Peri/Day 3 Extra
0.558
7.5277E−03

35435_s_at
Day 7 Peri/Day 7 Extra
0.692
5.5220E−03

189
10300
Entrez Gene
katanin p80 (WD repeat containing) subunit B 1
40976_at
Day 3 Intra/Day 3 Extra
0.559
9.1699E−03

190
55651
Entrez Gene
nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)
41322_s_at
Day 3 Peri/Day 3 Extra
0.559
1.2634E−03

41322_s_at
Day 3 Intra/Day 3 Extra
0.675
9.6475E−03

191
11336
Entrez Gene
SEC6-like 1 (S. cerevisiae)
37597_s_at
Day 3 Peri/Day 3 control
0.560
4.7635E−03

37597_s_at
Day 3 Peri/Day 3 Extra
0.566
9.6420E−04

192
7009
Entrez Gene
testis enhanced gene transcript (BAX inhibitor 1)
33988_at
Day 3 Peri/Day 3 Control
0.560
1.0937E−03

33988_at
Day 3 Peri/Day 3 Extra
0.582
8.2347E−04

193
23107
Entrez Gene
mitochondrial ribosomal protein S27
39377_at
Day 3 Peri/Day 3 Extra
0.561
3.7750E−03

39377_at
Day 3 Peri/Day 3 Control
0.571
9.8955E−03

39377_at
Day 3 Peri/Day 3 Intra
0.634
9.8004E−03

194
50
Entrez Gene
aconitase 2, mitochondrial
160044_g_at
Day 3 Peri/Day 3 Control
0.562
5.6984E−03

195
2746
Entrez Gene
glutamate dehydrogenase 1
31691_g_at
Day 3 Peri/Day 3 Control
0.563
6.9886E−03

196
57209
Entrez Gene
zinc finger protein 248
35139_at
Day 3 Intra/Day 0 Intra
0.565
2.1978E−03

197
6477
Entrez Gene
Seven in absentia homolog 1 (Drosophila)
32161_at
Day 0 Peri/Day 0 Intra
0.565
2.6625E−03

198
6166
Entrez Gene
ribosomal protein L36a-like
39856_at
Day 0 Peri/Day 0 Control
0.568
7.8476E−03

199
7175
Entrez Gene
translocated promoter region (to activated MET oncogene)
421_at
Day 0 Peri/Day 0 Control
0.569
3.6369E−03

200
8349
Entrez Gene
histone 2, H2be
33352_at
Day 3 Intra/Day 3 Control
0.570
6.1256E−03

33352_at
Day 3 Intra/Day 3 Extra
0.617
5.0561E−03

201
171546
Entrez Gene
chromosome 14 open reading frame 147
33399_at
Day 3 Peri/Day 3 Extra
0.571
4.6866E−03

33399_at
Day 3 Intra/Day 3 Extra
0.656
8.8383E−03

202
10553
Entrez Gene
HIV-1 Tat interactive protein 2, 30 kDa
38824_at
Day 3 Peri/Day 3 Control
0.571
7.2789E−03

38824_at
Day 3 Peri/Day 3 Extra
0.592
5.7073E−03

203
115817
Entrez Gene
dehydrogenase/reductase (SDR family) member 1
39103_s_at
Day 3 Peri/Day 3 Control
0.571
2.1724E−04

39103_s_at
Day 0 Intra/Day 0 Control
0.592
1.8258E−03

39103_s_at
Day 3 Peri/Day 3 Extra
0.601
5.7200E−03

204
25813
Entrez Gene
sorting and assembly machinery component 50
34845_at
Day 3 Peri/Day 3 Extra
0.572
1.2889E−03

homolog (S. cerevisiae)

205
25963
Entrez Gene
DKFZP564G2022 protein
40437_at
Day 3 Peri/Day 3 Control
0.572
3.2143E−03

206
1212
Entrez Gene
clathrin, light polypeptide (Lcb)
32523_at
Day 3 Peri/Day 3 Control
0.573
4.0809E−03

207
1652
Entrez Gene
D-dopachrome lautomerase
374_f_at
Day 7 Peri/Day 7 Control
0.573
7.7105E−03

208
27335
Entrez Gene
eukaryotic translation initiation factor 3, subunit 12
31492_at
Day 3 Peri/Day 3 Extra
0.574
7.4544E−04

209
217
Entrez Gene
aldehyde dehydrogenase 2 family (mitochondrial)
32747_at
Day 3 Peri/Day 3 Extra
0.574
5.1549E−04

32747_at
Day 7 Peri/Day 0 Peri
0.741
2.4111E−03

210
10049
Entrez Gene
DnaJ (Hsp40) homolog, subfamily B, member 6
41234_at
Day 7 Peri/Day 7 Extra
0.577
3.8743E−03

211
8315
Entrez Gene
BRCA1 associated protein
41512_at
Day 3 Intra/Day 0 Intra
0.577
1.1128E−03

41512_at
Day 3 Intra/Day 3 Peri
0.677
7.0812E−04

212
8623
Entrez Gene
acetylserotonin O-methyltransferase-like
36553_at
Day 3 Intra/Day 0 Intra
0.578
7.1773E−04

36553_at
Day 3 Peri/Day 0 Peri
0.710
1.0994E−04

213
169611
Entrez Gene
olfactomedin-like 2A
38312_at
Day 3 Intra/Day 0 Intra
0.579
3.6248E−03

38312_at
Day 3 Peri/Day 0 Peri
0.719
4.2489E−04

214
11066
Entrez Gene
U11/U12 snRNP 35K
41029_at
Day 3 Peri/Day 3 Extra
0.580
1.0146E−03

41029_at
Day 3 Intra/Day 3 Extra
0.589
7.2521E−03

215
9936
Entrez Gene
CD302 antigen
34760_at
Day 0 Peri/Day 0 Intra
0.580
5.4949E−04

216
4729
Entrez Gene
NADH dehydrogenase (ubiquinone) flavoprotein 2,
34893_at
Day 7 Peri/Day 7 Control
0.581
9.2931E−03

24 kDa
34893_at
Day 7 Peri/Day 7 Extra
0.600
1.3243E−03

217
987
Entrez Gene
LPS-responsive vesicle trafficking, beach and anchor
35371_at
Day 3 Peri/Day 3 Control
0.582
1.9359E−03

containing
35371_at
Day 3 Peri/Day 3 Extra
0.618
2.4693E−03

35371_at
Day 3 Intra/Day 3 Control
0.652
2.1271E−03

218
128
Entrez Gene
alcohol dehydrogenase 5 (class III), chi polypeptide
37708_r_at
Day 3 Intra/Day 0 Intra
0.582
8.9780E−03

37708_r_at
Day 0 Peri/Day 0 Intra
0.600
6.4350E−03

219
65055
Entrez Gene
chromosome 2 open reading frame 23
36096_at
Day 3 Intra/Day 3 Peri
0.583
2.9762E−03

220
7295
Entrez Gene
thioredoxin
36992_at
Day 3 Peri/Day 3 Extra
0.583
3.0827E−03

36992_at
Day 3 Peri/Day 3 Intra
0.673
4.8045E−03

221
5917
Entrez Gene
arginyl-tRNA synthetase
549_at
Day 7 Intra/Day 7 Extra
0.584
6.5983E−03

222
10980
Entrez Gene
COP9 constitutive photomorphogenic homolog subunit
40138_at
Day 7 Peri/Day 7 Control
0.584
6.5665E−03

6 (Arabidopsis)

223
2621
Entrez Gene
growth arrest-specific 6
1597_at
Day 3 Intra/Day 0 Intra
0.585
6.6299E−03

1597_at
Day 3 Peri/Day 0 Peri
0.689
5.8701E−03

224
831
Entrez Gene
calpastatin
41257_at
Day 3 Intra/Day 0 Intra
0.585
5.3045E−04

41257_at
Day 0 Peri/Day 0 Intra
0.700
3.4819E−03

225
5927
Entrez Gene
Jumonji, AT rich interactive domain 1A (RBBP2-like)
1785_at
Day 3 Intra/Day 3 Peri
0.585
3.1353E−03

226
2824
Entrez Gene
glycoprotein M6B
37251_s_at
Day 3 Intra/Day 3 Peri
0.586
8.6602E−03

227
1153
Entrez Gene
cold inducible RNA binding protein
39864_at
Day 3 Intra/Day 0 Intra
0.587
2.1268E−03

39864_at
Day 7 Intra/Day 0 Intra
0.611
6.9554E−03

228
645
Entrez Gene
biliverdin reductase B (flavin reductase (NADPH))
37002_at
Day 7 Peri/Day 7 Control
0.588
8.3451E−04

229
8581
Entrez Gene
lymphocyte antigen 6 complex, locus D
36284_at
Day 7 Peri/Day 7 Extra
0.589
9.2936E−03

230
AB006780
GenBank
lectin, galactoside-binding, soluble, 3 (galeclin 3) ///
35367_at
Day 3 Intra/Day 0 Intra
0.590
8.4864E−03

galectin-3 internal gene
35367_at
Day 7 Peri/Day 0 Peri
0.683
4.0159E−04

35367_at
Day 3 Peri/Day 0 Peri
0.763
8.3297E−03

231
6929
Entrez Gene
transcription factor 3 (E2A immunoglobulin enhancer
1373_at
Day 3 Intra/Day 0 Intra
0.590
2.7482E−03

binding factors E12/E47)
1373_at
Day 3 Peri/Day 0 Peri
0.738
3.1310E−04

232
10476
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F0
35760_at
Day 3 Peri/Day 3 Extra
0.590
1.5912E−03

complex, subunit d
35760_at
Day 0 Peri/Day 0 Control
0.738
8.9277E−03

233
7022
Entrez Gene
transcription factor AP-2 gamma (activating enhancer
40303_at
Day 3 Peri/Day 3 Control
0.591
7.9662E−03

binding protein 2 gamma)

234
2806
Entrez Gene
glutamic-oxaloacetic transaminase 2, mitochondrial
40764_at
Day 3 Peri/Day 3 Extra
0.591
2.0500E−03

(aspartate aminotransferase 2)

235
23185
Entrez Gene
La ribonucleoprotein domain family, member 5
32586_at
Day 0 Peri/Day 0 Control
0.591
3.7384E−03

32586_at
Day 3 Peri/Day 3 Control
0.685
8.4169E−04

32586_at
Day 3 Peri/Day 3 Extra
0.782
5.1596E−03

236
HG3254-HT343
The Institute for
—
1163_at
Day 3 Intra/Day 3 Control
0.591
5.8755E−03

Genomic Research

237
708
Entrez Gene
complement component 1, q subcomponent binding
37668_at
Day 3 Peri/Day 3 Extra
0.591
6.3705E−03

protein

238
81875
Entrez Gene
Interferon stimulated exonuclease gene 20 kDa-like 2
40946_at
Day 3 Peri/Day 3 Extra
0.593
3.2988E−03

239
AI032612
GenBank
enolase 1, (alpha) /// small nuclear ribonucleoprotein
41403_at
Day 3 Peri/Day 3 Extra
0.593
2.1695E−03

polypeptide F
41403_at
Day 7 Peri/Day 7 Extra
0.674
9.8788E−04

240
26040
Entrez Gene
SET binding protein 1
34990_at
Day 3 Peri/Day 0 Peri
0.593
3.4533E−04

34990_at
Day 7 Peri/Day 0 Peri
0.711
9.8766E−03

241
8673
Entrez Gene
vesicle-associated membrane protein 8 (endobrevin)
32715_at
Day 3 Peri/Day 3 Extra
0.593
2.2624E−03

32715_at
Day 0 Peri/Day 0 Control
0.628
1.3473E−03

242
23353
Entrez Gene
unc-84 homolog A (C. elegans)
36588_at
Day 7 Intra/Day 0 Intra
0.594
2.9354E−03

243
4255
Entrez Gene
O-6-methylguanine-DNA methyltransferase
2051_at
Day 7 Peri/Day 7 Control
0.594
5.4697E−03

244
6670
Entrez Gene
Sp3 transcription factor
41573_at
Day 3 Intra/Day 0 Intra
0.594
6.5653E−03

245
6249
Entrez Gene
restin (Reed-Steinberg cell-expressed intermediate
34350_at
Day 7 Peri/Day 7 Extra
0.595
8.1420E−03

filament-associated protein)

246
11188
Entrez Gene
nischarin
33916_at
Day 0 Peri/Day 0 Control
0.595
3.7132E−03

33916_at
Day 3 Peri/Day 3 Control
0.647
6.0432E−03

247
2355
Entrez Gene
FOS-like antigen 2
40268_at
Day 0 Intra/Day 0 Peri
0.596
5.8255E−03

248
2547
Entrez Gene
X-ray repair complementing defective repair in Chinese
32766_at
Day 3 Peri/Day 3 Extra
0.597
8.7735E−04

hamster cells 6 (Ku autoantigen, 70 kDa)

249
545
Entrez Gene
ataxia talangiectasia and Rad3 related
37229_at
Day 7 Intra/Day 7 Extra
0.597
5.6822E−03

37229_at
Day 7 Peri/Day 7 Extra
0.619
5.1546E−03

250
4775
Entrez Gene
nuclear factor of activated T-cells, cytoplasmic,
40822_at
Day 0 Peri/Day 0 Control
0.597
3.4027E−03

calcineurin-dependent 3
40823_s_at
Day 3 Peri/Day 3 Extra
0.633
7.3198E−03

40822_at
Day 0 Peri/Day 0 Intra
0.746
7.0070E−03

251
8776
Entrez Gene
myotubularin related protein 1
34654_at
Day 3 Intra/Day 3 Extra
0.598
1.6699E−03

34654_at
Day 3 Intra/Day 3 Control
0.631
5.7609E−03

252
4790
Entrez Gene
nuclear factor of kappa light polypeptide gene enhancer
1378_g_at
Day 3 Peri/Day 3 Extra
0.598
6.5881E−03

in B-cells 1 (p105)
1378_g_at
Day 0 Peri/Day 0 Control
0.646
7.6400E−03

253
AL080234
GenBank
Full-length cDNA clone CS0DM001YA04 of Fetal liver
38070_at
Day 7 Intra/Day 0 Intra
0.598
4.0826E−03

of Homo sapiens (human)

254
26135
Entrez Gene
SERPINE1 mRNA binding protein 1
40440_at
Day 0 Peri/Day 0 Control
0.599
7.7405E−03

40440_at
Day 3 Peri/Day 3 Intra
0.727
9.5681E−03

255
23234
Entrez Gene
DnaJ (Hsp40) homolog, subfamily C, member 9
41569_at
Day 7 Peri/Day 7 Extra
0.599
4.9293E−03

41569_at
Day 7 Intra/Day 7 Extra
0.615
8.2268E−03

256
94239
Entrez Gene
H2A histone family, member V
39046_at
Day 3 Intra/Day 0 Intra
0.600
7.9321E−03

39046_at
Day 7 Intra/Day 0 Intra
0.650
5.0612E−03

257
AI557912
GenBank
translocase of outer mitochondrial membrane 7
39025_at
Day 7 Intra/Day 0 Intra
0.601
3.8343E−03

homolog (yeast) /// hypothetical protein LOC201725
39025_at
Day 7 Peri/Day 7 Control
0.716
2.2149E−03

39025_at
Day 7 Intra/Day 7 Control
0.727
5.2071E−03

39025_at
Day 7 Peri/Day 0 Peri
0.798
1.0424E−03

258
4437
Entrez Gene
mutS homolog 3 (E. coli)
1719_at
Day 3 Peri/Day 3 Extra
0.603
6.7926E−03

259
3550
Entrez Gene
IK cytokine, down-regulator of HLA II
218_at
Day 3 Peri/Day 3 Control
0.606
4.9835E−04

260
5453
Entrez Gene
POU domain class 3, transcription factor 1
33675_at
Day 3 Peri/Day 0 Peri
0.606
4.5158E−03

261
6651
Entrez Gene
SON DNA binding protein
39096_at
Day 7 Intra/Day 0 Intra
0.607
3.4000E−03

39096_at
Day 7 Intra/Day 7 Peri
0.641
4.2992E−03

39096_at
Day 7 Intra/Day 3 Intra
0.710
4.2168E−03

262
353
Entrez Gene
adenine phosphoribosyltransferase
34310_at
Day 3 Peri/Day 3 Control
0.607
7.6231E−03

34310_at
Day 3 Peri/Day 3 Intra
0.619
3.4883E−03

263
6427
Entrez Gene
splicing factor, arginine/serine-rich 2
36111_s_at
Day 7 Peri/Day 7 Extra
0.607
1.0792E−03

36111_s_at
Day 7 Intra/Day 7 Extra
0.665
1.5173E−04

36111_s_at
Day 7 Intra/Day 3 Intra
0.709
6.0916E−03

264
221749
Entrez Gene
chromosome 6 open reading frame 145
34246_at
Day 3 Intra/Day 0 Intra
0.608
3.6829E−03

265
79703
Entrez Gene
hypothetical protein FLJ22531
41804_at
Day 3 Peri/Day 3 Control
0.608
1.1934E−04

266
27292
Entrez Gene
dimethyladenosine transferase
39883_at
Day 7 Peri/Day 7 Extra
0.609
2.6811E−03

267
54665
Entrez Gene
round spermatid basic protein 1
37828_at
Day 3 Intra/Day 0 Intra
0.610
7.8572E−04

37828_at
Day 0 Peri/Day 0 Intra
0.626
4.8045E−03

268
513
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F1
37992_s_at
Day 7 Peri/Day 7 Control
0.611
6.2111E−03

complex, delta subunit

269
AL050091
GenBank
glutamate receptor, ionotropic, N-methyl D-aspartate-
35736_at
Day 0 Peri/Day 0 Control
0.611
4.7952E−03

like 1A /// GRINL1A combined protein /// similar to

glutamate receptor, ionotropic, N-methyl D-a

270
3301
Entrez Gene
DnaJ (Hsp40) homolog, subfamily A, member 1
39118_at
Day 7 Intra/Day 7 Extra
0.611
5.7425E−03

271
9349
Entrez Gene
ribosomal protein L23
32395_r_at
Day 3 Peri/Day 3 Extra
0.611
2.2508E−03

272
22826
Entrez Gene
DnaJ (Hsp40) homolog, subfamily C, member 8
36166_at
Day 0 Intra/Day 0 Control
0.612
5.7794E−03

273
23090
Entrez Gene
zinc finger protein 423
34950_at
Day 3 Peri/Day 0 Peri
0.613
2.6182E−04

34950_at
Day 7 Intra/Day 7 Peri
0.623
7.6235E−03

274
64112
Entrez Gene
modulator of apoptosis 1
34767_at
Day 3 Intra/Day 0 Intra
0.614
4.4658E−03

275
10497
Entrez Gene
unc-13 homolog B (C. elegans)
40087_at
Day 3 Peri/Day 3 Control
0.614
3.7491E−03

40087_at
Day 0 Intra/Day 0 Control
0.769
3.3634E−03

276
56957
Entrez Gene
chromosome 14 open reading frame 132
41837_at
Day 3 Peri/Day 0 Peri
0.614
6.2326E−04

41837_at
Day 7 Peri/Day 0 Peri
0.660
1.7553E−03

277
8560
Entrez Gene
degenerative spermatocyte homolog 1, lipid desaturase
33337_at
Day 3 Peri/Day 3 Control
0.614
8.5255E−03

(Drosophila)
33337_at
Day 7 Peri/Day 7 Control
0.626
3.0395E−03

33337_at
Day 7 Peri/Day 0 Peri
0.690
1.2271E−03

278
10975
Entrez Gene
ubiquinol-cytochrome c reductase, 6.4 kDa subunit
38451_at
Day 7 Peri/Day 7 Control
0.614
8.2100E−05

279
10641
Entrez Gene
tumor suppressor candidate 4
40497_at
Day 0 Peri/Day 0 Control
0.614
9.7424E−03

40497_at
Day 3 Peri/Day 3 Control
0.655
1.1667E−04

280
8663
Entrez Gene
eukaryotic translation initiation factor 3, subunit 8,
34841_at
Day 3 Peri/Day 3 Extra
0.615
9.0352E−03

110 kDa
34841_at
Day 3 Peri/Day 0 Peri
0.776
9.4126E−03

281
50717
Entrez Gene
WD repeat domain 42A
39823_at
Day 3 Peri/Day 3 Control
0.616
2.9015E−03

282
23392
Entrez Gene
KIAA0368
34414_at
Day 7 Intra/Day 0 Intra
0.616
1.2883E−03

34414_at
Day 0 Peri/Day 0 Intra
0.644
5.3735E−03

283
5934
Entrez Gene
retinoblastoma-like 2 (p130)
32597_at
Day 3 Intra/Day 0 Intra
0.616
8.7510E−03

284
4781
Entrez Gene
Nuclear factor I/B
41229_at
Day 3 Intra/Day 0 Intra
0.616
3.0477E−03

285
23650
Entrez Gene
tripartite motif-containing 29
1898_at
Day 7 Peri/Day 0 Peri
0.617
3.0138E−03

286
8665
Entrez Gene
eukaryotic translation initiation factor 3, subunit 5
32576_at
Day 3 Peri/Day 3 Extra
0.617
4.1860E−03

epsilon, 47 kDa

287
7203
Entrez Gene
chaperonin containing TCP1, subunit 3 (gamma)
40774_at
Day 3 Peri/Day 3 Extra
0.617
6.5552E−03

288
3418
Entrez Gene
Isocitrate dehydrogenase 2 (NADP+), mitochondrial
32332_at
Day 0 Intra/Day 0 Peri
0.617
1.2980E−03

289
9
Entrez Gene
N-acetyltransferase 1 (arylamine N-acetyltransferase)
38187_at
Day 7 Intra/Day 7 Extra
0.619
5.7524E−03

290
25797
Entrez Gene
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
35966_at
Day 3 Intra/Day 0 Intra
0.619
4.9522E−03

35966_at
Day 0 Peri/Day 0 Intra
0.663
6.8919E−03

291
5092
Entrez Gene
6-pyruvoyl-tetrahydropterin synthase/dimerization
34352_at
Day 7 Peri/Day 7 Control
0.620
2.4354E−03

cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
34352_at
Day 3 Peri/Day 3 Intra
0.704
1.5982E−03

292
7818
Entrez Gene
death associated protein 3
1356_at
Day 0 Peri/Day 0 Control
0.621
1.4788E−03

293
U05861
GenBank
aldo-keto reductase family 1, member C1 (dihydrodiol
32805_at
Day 3 Peri/Day 3 Extra
0.621
6.7226E−03

dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid

dehydrogenase) /// aldo-keto reductase family

294
23063
Entrez Gene
KIAA0261
40086_at
Day 3 Peri/Day 3 Control
0.623
5.5939E−03

295
9529
Entrez Gene
BCL2-associated athanogene 5
36463_at
Day 3 Peri/Day 3 Extra
0.624
7.6918E−03

296
57147
Entrez Gene
SCY1-like 3 (S. cerevisiae)
41329_at
Day 3 Peri/Day 3 Control
0.624
2.9063E−03

297
8888
Entrez Gene
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
40469_at
Day 7 Intra/Day 7 Extra
0.624
4.8160E−03

associated protein

298
10289
Entrez Gene
translation factor sui1 homolog
33351_at
Day 0 Peri/Day 0 Intra
0.624
5.2711E−04

33351_at
Day 3 Intra/Day 0 Intra
0.673
1.7268E−03

299
9536
Entrez Gene
prostaglandin E synthase
38131_at
Day 3 Peri/Day 3 Extra
0.626
9.0721E−03

300
22883
Entrez Gene
calsyntenin 1
41498_at
Day 3 Peri/Day 3 Control
0.626
9.2124E−04

41498_at
Day 3 Peri/Day 0 Peri
0.777
3.9252E−03

301
7520
Entrez Gene
X-ray repair complementing defective repair in Chinese
2093_s_at
Day 3 Peri/Day 3 Control
0.627
1.0646E−03

hamster cells 5 (double-strand-break rejoining; Ku
38733_at
Day 0 Peri/Day 0 Control
0.644
9.6568E−03

autoantigen, 80 kDa)

302
24139
Entrez Gene
echinoderm microtubule associated protein like 2
41328_s_at
Day 0 Intra/Day 0 Peri
0.627
4.4037E−03

303
4928
Entrez Gene
nucleoporin 98 kDa
38911_at
Day 3 Peri/Day 3 Extra
0.627
2.3405E−03

304
3290
Entrez Gene
hydroxysteroid (11-beta) dehydrogenase 1
35702_at
Day 7 Peri/Day 0 Peri
0.628
6.5442E−03

305
23351
Entrez Gene
KIAA0323
32592_at
Day 0 Peri/Day 0 Control
0.628
8.9436E−04

32592_at
Day 0 Intra/Day 0 Control
0.679
8.2136E−03

306
2065
Entrez Gene
v-erb-b2 erythroblastic leukemia viral oncogene
2089_s_at
Day 0 Peri/Day 0 Control
0.629
5.0250E−03

homolog 3 (avian)
32787_at
Day 7 Peri/Day 0 Peri
0.677
7.5081E−03

307
10217
Entrez Gene
CTD (carboxy-terminal domain, RNA polymerase II,
40196_at
Day 3 Peri/Day 3 Control
0.630
3.3471E−03

polypeptide A) small phosphatase-like
40196_at
Day 7 Peri/Day 0 Peri
0.735
2.0122E−03

40196_at
Day 3 Peri/Day 0 Peri
0.770
5.2302E−03

308
23658
Entrez Gene
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
34270_at
Day 3 Peri/Day 3 Control
0.631
1.9266E−03

309
W28948
GenBank
Full length insert cDNA YH77E09
37161_at
Day 3 Peri/Day 3 Extra
0.631
4.5494E−03

37161_at
Day 3 Peri/Day 3 Control
0.640
6.9170E−03

310
22903
Entrez Gene
BTB (POZ) domain containing 3
37755_at
Day 3 Intra/Day 0 Intra
0.631
9.7703E−03

311
4681
Entrez Gene
neuroblastoma, suppression of tumorigenicity 1
37005_at
Day 0 Intra/Day 0 Peri
0.631
3.2813E−03

37005_at
Day 7 Peri/Day 0 Peri
0.642
1.7449E−03

37005_at
Day 3 Peri/Day 0 Peri
0.695
2.4042E−03

312
10301
Entrez Gene
deleted in lymphocytic leukemia, 1
33791_at
Day 7 Intra/Day 0 Intra
0.631
8.9965E−03

33791_at
Day 3 Intra/Day 0 Intra
0.726
6.7457E−03

313
AF052138
GenBank
FLJ35348 /// Bromodomain containing 3
41841_at
Day 3 Intra/Day 0 Intra
0.632
4.2490E−03

314
6209
Entrez Gene
ribosomal protein S15
39916_r_at
Day 7 Peri/Day 7 Control
0.633
1.4158E−03

39916_r_at
Day 3 Peri/Day 3 Control
0.675
7.7101E−03

315
8930
Entrez Gene
methyl-CpG binding domain protein 4
34386_at
Day 7 Intra/Day 7 Extra
0.634
3.7388E−03

316
8824
Entrez Gene
carboxylesterase 2 (intestine, liver)
40882_at
Day 7 Peri/Day 7 Intra
0.635
9.8901E−03

317
10961
Entrez Gene
endoplasmic reticulum protein 29
36945_at
Day 3 Peri/Day 3 Control
0.635
9.2309E−04

318
7265
Entrez Gene
tetratricopeptide repeat domain 1
37321_at
Day 3 Peri/Day 3 Control
0.635
7.5603E−03

319
1428
Entrez Gene
crystallin, mu
38285_at
Day 3 Intra/Day 0 Intra
0.636
1.2448E−03

320
10614
Entrez Gene
Hexamethylene bis-acetamide inducible 1
40220_at
Day 3 Intra/Day 0 Intra
0.636
3.7740E−03

321
6128
Entrez Gene
ribosomal protein L6
31952_at
Day 3 Peri/Day 3 Extra
0.637
8.7667E−03

322
5245
Entrez Gene
prohibitin
36592_at
Day 3 Peri/Day 3 Extra
0.637
3.4444E−03

323
9296
Entrez Gene
ATPase, H+ transporting, lysosomal 14 kDa, V1 subunit F
37395_at
Day 7 Peri/Day 7 Control
0.638
2.2448E−03

37395_at
Day 3 Peri/Day 3 Control
0.722
8.6817E−04

37395_at
Day 3 Peri/Day 3 Extra
0.810
7.4746E−03

37395_at
Day 7 Peri/Day 0 Peri
0.840
4.0330E−03

324
1340
Entrez Gene
cytochrome c oxidase subunit Vib polypeptide 1
40872_at
Day 3 Peri/Day 3 Extra
0.638
1.3105E−03

(ubiquitous)
40872_at
Day 3 Intra/Day 3 Extra
0.698
6.3894E−03

325
1891
Entrez Gene
enoyl Coenzyme A hydratase 1, peroxisomal
32756_at
Day 3 Peri/Day 3 Extra
0.638
8.7097E−03

326
1632
Entrez Gene
dodecenoyl-Coenzyme A delta isomerase (3,2 trans-
37982_at
Day 7 Peri/Day 7 Control
0.639
2.3722E−03

enoyl-Coenzyme A isomerase)

327
1933
Entrez Gene
eukaryotic translation elongation factor 1 beta 2
35748_at
Day 3 Peri/Day 3 Extra
0.639
7.6265E−04

328
6141
Entrez Gene
ribosomal protein L18
31546_at
Day 7 Peri/Day 7 Control
0.639
6.9963E−03

31546_at
Day 3 Peri/Day 3 Extra
0.691
6.7124E−03

31546_at
Day 7 Peri/Day 0 Peri
0.760
9.8180E−03

329
4026
Entrez Gene
LIM domain containing preferred translocation partner in
41195_at
Day 3 Intra/Day 3 Peri
0.639
3.3595E−03

lipoma

330
6950
Entrez Gene
t-complex 1
34791_at
Day 3 Peri/Day 3 Extra
0.640
3.7040E−03

331
29760
Entrez Gene
B-cell linker
38242_at
Day 3 Peri/Day 3 Extra
0.640
7.2677E−04

332
573
Entrez Gene
BCL2-associated athanogene
34798_at
Day 3 Peri/Day 3 Control
0.642
4.4022E−03

333
2709
Entrez Gene
gap junction protein, beta 5 (connexin 31.1)
38903_at
Day 7 Peri/Day 0 Peri
0.643
1.7967E−03

334
6230
Entrez Gene
ribosomal protein S25
31573_at
Day 7 Intra/Day 0 Intra
0.643
9.4033E−03

335
11083
Entrez Gene
death associated transcription factor 1
32045_at
Day 0 Peri/Day 0 Control
0.644
6.8658E−03

336
10247
Entrez Gene
heat-responsive protein 12
32173_at
Day 7 Peri/Day 7 Extra
0.645
6.3967E−03

32173_at
Day 3 Peri/Day 3 Control
0.659
6.9500E−03

337
27067
Entrez Gene
staufen, RNA binding protein, homolog 2 (Drosophila)
38341_at
Day 3 Intra/Day 3 Extra
0.645
8.2036E−03

338
899
Entrez Gene
cyclin F
35907_at
Day 3 Peri/Day 3 Extra
0.646
8.5538E−03

339
HG162-HT3165
The Institute for
—
1278_at
Day 3 Peri/Day 0 Peri
0.647
6.0118E−03

Genomic Research

340
6139
Entrez Gene
ribosomal protein L17
32440_at
Day 3 Peri/Day 3 Extra
0.647
6.1617E−03

341
9521
Entrez Gene
eukaryotic translation elongation factor 1 epsilon 1
40587_s_at
Day 7 Intra/Day 3 Intra
0.647
1.9928E−03

40587_s_at
Day 3 Peri/Day 3 Intra
0.697
4.8656E−04

40587_s_at
Day 3 Peri/Day 3 Extra
0.718
6.3530E−03

342
1054
Entrez Gene
CCAAT/enhancer binding protein (C/EBP), gamma
39219_at
Day 7 Peri/Day 7 Extra
0.647
8.7653E−03

39219_at
Day 7 Intra/Day 7 Extra
0.676
1.0916E−03

343
7739
Entrez Gene
zinc finger protein 185 (LIM domain)
32139_at
Day 0 Peri/Day 0 Control
0.648
5.7560E−03

344
8664
Entrez Gene
eukaryotic translation initiation factor 3, subunit 7 zeta,
35298_at
Day 3 Peri/Day 3 Extra
0.649
2.0180E−03

66/67 kDa

345
57418
Entrez Gene
WD repeat domain 18
35983_at
Day 3 Peri/Day 3 Extra
0.651
3.7380E−03

346
6187
Entrez Gene
ribosomal protein S2
31527_at
Day 3 Peri/Day 3 Extra
0.651
6.9801E−03

347
11079
Entrez Gene
RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)
41551_at
Day 7 Peri/Day 7 Extra
0.651
8.1132E−03

348
26211
Entrez Gene
olfactory receptor, family 2, subfamily F, member 1
31921_at
Day 3 Peri/Day 3 Control
0.652
2.1176E−03

349
6206
Entrez Gene
ribosomal protein S12
33117_r_at
Day 3 Peri/Day 3 Extra
0.652
2.4740E−03

350
9798
Entrez Gene
KIAA0174
36942_at
Day 0 Peri/Day 0 Control
0.653
5.6656E−03

351
132556
Entrez Gene
similar to Transcription factor BTF3 homolog 3
31519_f_at
Day 0 Peri/Day 0 Intra
0.653
9.2891E−03

352
8732
Entrez Gene
RNA guanylyltransferase and 5′-phosphatase
35202_at
Day 7 Intra/Day 7 Extra
0.654
1.2688E−03

353
4070
Entrez Gene
tumor-associated calcium signal transducer 2
291_s_at
Day 0 Peri/Day 0 Control
0.654
9.5683E−03

291_s_at
Day 3 Peri/Day 3 Extra
0.655
8.7414E−03

354
7152
Entrez Gene
topoisomerase (DNA) I pseudogene 2
31680_at
Day 7 Peri/Day 7 Extra
0.654
8.0454E−03

355
4615
Entrez Gene
myeloid differentiation primary response gene (88)
38369_at
Day 7 Peri/Day 7 Extra
0.654
5.5186E−03

356
51567
Entrez Gene
TRAF and TNF receptor associated protein
34825_at
Day 3 Intra/Day 3 Extra
0.655
3.0500E−05

357
9377
Entrez Gene
cytochrome c oxidase subunit Va
41223_at
Day 3 Peri/Day 3 Extra
0.656
7.0969E−03

358
7386
Entrez Gene
ubiquinol-cytochrome c reductase, Rieske iron-sulfur
34401_at
Day 3 Peri/Day 3 Extra
0.656
5.8159E−03

polypeptide 1

359
4835
Entrez Gene
NAD(P)H dehydrogenase, quinone 2
36880_at
Day 7 Peri/Day 7 Control
0.657
7.2935E−03

360
3298
Entrez Gene
heat shock transcription factor 2
202_at
Day 7 Intra/Day 0 Intra
0.658
7.1609E−03

361
4677
Entrez Gene
asparaginyl-tRNA synthetase
41241_at
Day 0 Intra/Day 0 Control
0.658
3.0519E−03

362
HG1980-HT202
The institute for
—
956_at
Day 7 Peri/Day 7 Extra
0.658
8.0238E−03

Genomic Research

363
23384
Entrez Gene
KIAA0376 protein
34837_at
Day 3 Intra/Day 0 Intra
0.659
2.3071E−03

364
54107
Entrez Gene
polymerase (DNA directed), epsilon 3 (p17 subunit)
38702_at
Day 3 Peri/Day 3 Extra
0.660
3.6355E−03

365
6635
Entrez Gene
small nuclear ribonucleoprotein polypeptide E
38679_g_at
Day 7 Intra/Day 7 Extra
0.661
3.7759E−04

38679_g_at
Day 7 Intra/Day 3 Intra
0.697
1.8800E−05

366
8192
Entrez Gene
CIpP caseinolytic peptidase, ATP-dependent,
32528_at
Day 7 Peri/Day 7 Intra
0.661
7.3475E−03

proteolytic subunit homolog (E. coli)

367
51690
Entrez Gene
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
36846_s_at
Day 7 Peri/Day 7 Control
0.662
8.8105E−04

368
5936
Entrez Gene
RNA binding motif protein 4
35351_at
Day 3 Peri/Day 3 Extra
0.662
1.3875E−03

369
7004
Entrez Gene
TEA domain family member 4
41037_at
Day 7 Peri/Day 7 Extra
0.662
6.4186E−04

41037_at
Day 7 Intra/Day 7 Extra
0.710
7.7243E−03

41037_at
Day 0 Intra/Day 0 Peri
0.755
4.0427E−03

370
3094
Entrez Gene
histidine triad nucleotide binding protein 1
1009_at
Day 3 Peri/Day 3 Extra
0.662
6.3134E−03

1009_at
Day 3 Peri/Day 3 Intra
0.704
8.1604E−03

371
4832
Entrez Gene
non-metastatic cells 3, protein expressed in
197_at
Day 3 Intra/Day 3 Control
0.663
6.9663E−03

372
10557
Entrez Gene
ribonuclease P/MRP 38 kDa subunit
41040_at
Day 7 Peri/Day 7 Extra
0.663
2.3436E−03

41040_at
Day 7 Intra/Day 7 Extra
0.667
4.5174E−03

373
26156
Entrez Gene
ribosomal L1 domain containing 1
39418_at
Day 7 Peri/Day 7 Extra
0.664
2.4392E−03

39418_at
Day 7 Intra/Day 3 Intra
0.691
5.6288E−03

39418_at
Day 3 Peri/Day 3 Extra
0.730
4.3297E−03

374
6122
Entrez Gene
ribosomal protein L3
31722_at
Day 3 Peri/Day 3 Extra
0.665
8.4932E−03

31722_at
Day 7 Peri/Day 0 Peri
0.792
9.5624E−03

375
6176
Entrez Gene
ribosomal protein, large, P1
31957_r_at
Day 7 Peri/Day 0 Peri
0.666
3.7416E−03

376
26053
Entrez Gene
autism susceptibility candidate 2
35648_at
Day 3 Intra/Day 0 Intra
0.667
3.9622E−03

377
56339
Entrez Gene
Methyltransferase like 3
32244_at
Day 3 Intra/Day 0 Intra
0.667
8.9345E−04

32244_at
Day 3 Intra/Day 3 Extra
0.726
7.6780E−03

378
10014
Entrez Gene
histone deacetylase 5
38810_at
Day 3 Peri/Day 3 Control
0.667
1.7702E−04

38810_at
Day 7 Peri/Day 0 Peri
0.778
7.8739E−03

38810_at
Day 3 Peri/Day 0 Peri
0.784
9.3572E−04

379
10610
Entrez Gene
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-
34693_at
Day 7 Peri/Day 0 Peri
0.668
5.8340E−04

1,3)-N-acetylgalactosaminide alpha-2,6-

sialyltransferase 2

380
HG662-HT662
The Institute for
—
1151_at
Day 3 Peri/Day 3 Control
0.669
1.5550E−03

Genomic Research

381
10694
Entrez Gene
chaperonin containing TCP1, subunit 8 (theta)
39767_at
Day 3 Peri/Day 3 Extra
0.669
4.6792E−03

382
10038
Entrez Gene
poly (ADP-ribose) polymerase family, member 2
34756_g_at
Day 7 Intra/Day 7 Extra
0.669
7.1429E−03

383
4856
Entrez Gene
nephroblastoma overexpressed gene
39250_at
Day 3 Peri/Day 0 Peri
0.670
5.1134E−03

384
9314
Entrez Gene
Kruppel-like factor 4 (gut)
36214_at
Day 7 Peri/Day 0 Peri
0.670
7.5246E−03

385
4694
Entrez Gene
NADH dehydrogenase (ubiquinone) 1 alpha
36169_at
Day 3 Peri/Day 3 Control
0.671
5.9310E−04

subcomplex, 1, 7.5 kDa
36169_at
Day 3 Peri/Day 3 Extra
0.706
1.3204E−03

36169_at
Day 7 Peri/Day 7 Control
0.710
9.3036E−03

36169_at
Day 3 Peri/Day 3 Intra
0.754
3.5482E−03

386
10904
Entrez Gene
bladder cancer associated protein
35267_g_at
Day 7 Intra/Day 0 Intra
0.672
2.1451E−03

35266_at
Day 3 Peri/Day 0 Peri
0.815
4.1112E−03

387
7411
Entrez Gene
von Hippel-Lindau binding protein 1
171_at
Day 7 Intra/Day 7 Extra
0.672
7.7370E−03

388
10682
Entrez Gene
emopamil binding protein (sterol isomerase)
32536_at
Day 3 Peri/Day 3 Extra
0.672
3.7237E−03

389
8667
Entrez Gene
eukaryotic translation initiation factor 3, subunit 3
35327_at
Day 3 Peri/Day 3 Control
0.672
5.0660E−03

gamma, 40 kDa

390
1349
Entrez Gene
cytochrome c oxidase subunit VIIb
36687_at
Day 7 Intra/Day 3 Intra
0.673
1.8885E−03

391
54462
Entrez Gene
KIAA1128
37617_at
Day 3 Intra/Day 0 Intra
0.674
5.5416E−03

37617_at
Day 3 Intra/Day 3 Control
0.696
9.3133E−03

392
80003
Entrez Gene
pecanex-like 2 (Drosophila)
39650_s_at
Day 3 Intra/Day 0 Intra
0.674
6.1109E−03

393
25972
Entrez Gene
unc-50 homolog (C. elegans)
39442_at
Day 7 Intra/Day 7 Extra
0.675
9.6835E−03

394
64795
Entrez Gene
hypothetical protein FLJ13910
36580_at
Day 3 Intra/Day 0 Intra
0.676
3.2610E−03

395
5441
Entrez Gene
polymerase (RNA) II (DNA directed) polypeptide L,
35841_at
Day 7 Peri/Day 7 Control
0.676
2.4659E−03

7.6 kDa

396
2146
Entrez Gene
enhancer of zeste homolog 2 (Drosophila)
37305_at
Day 7 Peri/Day 7 Extra
0.677
5.6094E−03

37305_at
Day 3 Peri/Day 3 Extra
0.701
9.0063E−03

397
7743
Entrez Gene
zinc finger protein 189
36072_at
Day 3 Intra/Day 0 Intra
0.678
3.7246E−03

398
2950
Entrez Gene
glutathione S-transferase pI
33396_at
Day 3 Peri/Day 3 Extra
0.679
6.0265E−03

33396_at
Day 7 Peri/Day 7 Extra
0.695
5.1049E−03

399
50813
Entrez Gene
COP9 constitutive photomorphogenic homolog subunit
34404_at
Day 0 Intra/Day 0 Peri
0.681
4.7805E−03

7A (Arabidopsis)

400
3156
Entrez Gene
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
39328_at
Day 3 Intra/Day 3 Extra
0.681
6.1525E−03

401
6156
Entrez Gene
ribosomal protein L30
31708_at
Day 3 Peri/Day 3 Extra
0.682
4.7648E−03

402
516
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F0
38076_at
Day 3 Peri/Day 3 Extra
0.682
3.2512E−04

complex, subunit c (subunit 9), isoform 1

403
9128
Entrez Gene
PRP4 pre-mRNA processing factor 4 homolog (yeast)
37936_at
Day 3 Peri/Day 3 Extra
0.682
1.2100E−03

37936_at
Day 3 Peri/Day 3 Intra
0.809
4.3656E−03

404
3028
Entrez Gene
hydroxyacyl-Coenzyme A dehydrogenase, type II
40778_at
Day 3 Peri/Day 3 Control
0.683
9.5528E−03

40778_at
Day 3 Peri/Day 3 Extra
0.687
5.4834E−03

40778_at
Day 0 Peri/Day 0 Control
0.700
6.7401E−03

40778_at
Day 7 Peri/Day 0 Peri
0.785
3.6406E−03

405
2961
Entrez Gene
general transcription factor IIE, polypeptide 2, beta
37295_at
Day 7 Peri/Day 7 Extra
0.683
5.1041E−03

34 kDa
37295_at
Day 7 Intra/Day 7 Extra
0.796
1.4862E−03

406
10969
Entrez Gene
EBNA1 binding protein 2
36135_at
Day 3 Peri/Day 3 Extra
0.683
7.3375E−03

407
6748
Entrez Gene
signal sequence receptor, delta (translocon-associated
38635_at
Day 7 Peri/Day 7 Control
0.684
3.2000E−03

protein delta)

408
4610
Entrez Gene
v-myc myelocytomatosis viral oncogene homolog 1,
1490_at
Day 3 Peri/Day 0 Peri
0.684
2.9494E−04

lung carcinoma derived (avian)

409
4170
Entrez Gene
myeloid cell leukemia sequence 1 (BCL2-related)
277_at
Day 3 Intra/Day 3 Extra
0.684
9.6905E−03

410
23075
Entrez Gene
SWAP-70 protein
31869_at
Day 0 Peri/Day 0 Intra
0.684
5.9906E−03

411
1537
Entrez Gene
cytochrome c-1
1160_at
Day 3 Peri/Day 3 Control
0.685
9.9616E−03

412
6768
Entrez Gene
suppression of tumorigenicity 14 (colon carcinoma,
35309_at
Day 3 Peri/Day 3 Extra
0.685
2.8284E−03

matriptase, epithin)

413
6138
Entrez Gene
ribosomal protein L15
32433_at
Day 0 Peri/Day 0 Intra
0.686
4.8021E−03

414
23112
Entrez Gene
trinucleotide repeat containing 6B
37487_at
Day 3 Intra/Day 3 Peri
0.688
3.9849E−03

415
64976
Entrez Gene
mitochondrial ribosomal protein L40
32745_at
Day 3 Peri/Day 3 Control
0.688
7.4413E−03

416
10420
Entrez Gene
testis-specific kinase 2
33164_at
Day 7 Peri/Day 0 Peri
0.688
8.0384E−03

417
9759
Entrez Gene
histone deacetylase 4
38271_at
Day 3 Intra/Day 0 Intra
0.689
4.9833E−03

38271_at
Day 0 Peri/Day 0 Intra
0.776
6.2327E−03

418
4676
Entrez Gene
nucleosome assembly protein 1-like 4
32575_at
Day 3 Peri/Day 3 Control
0.689
7.9600E−05

32575_at
Day 7 Intra/Day 7 Extra
0.790
4.9890E−03

32575_at
Day 3 Peri/Day 3 Intra
0.820
9.3028E−03

419
5425
Entrez Gene
polymerase (DNA directed), delta 2, regulatory subunit
1470_at
Day 3 Peri/Day 3 Intra
0.689
5.7659E−03

50 kDa

420
6390
Entrez Gene
succinate dehydrogenase complex, subunit B, iron
35751_at
Day 3 Peri/Day 3 Extra
0.689
9.9046E−03

sulfur (Ip)

421
162
Entrez Gene
adaptor-related protein complex 1, beta 1 subunit
40745_at
Day 3 Peri/Day 3 Extra
0.689
1.6623E−03

422
1749
Entrez Gene
distal-less homeo box 5
41087_at
Day 3 Intra/Day 0 Intra
0.689
3.6526E−03

423
6749
Entrez Gene
structure specific recognition protein 1
37739_at
Day 3 Peri/Day 3 Extra
0.690
4.8988E−03

424
4134
Entrez Gene
microtubule-associated protein 4
33850_at
Day 3 Peri/Day 0 Peri
0.690
9.2919E−04

33850_at
Day 7 Peri/Day 0 Peri
0.747
8.7450E−03

425
6832
Entrez Gene
suppressor of var1, 3-like 1 (S. cerevisiae)
41408_at
Day 3 Peri/Day 3 Extra
0.691
6.4202E−03

426
10939
Entrez Gene
AFG3 ATPase family gene 3-like 2 (yeast)
34315_at
Day 3 Peri/Day 3 Extra
0.692
3.6562E−04

427
22794
Entrez Gene
cancer susceptibility candidate 3
38437_at
Day 7 Intra/Day 0 Intra
0.692
2.7057E−03

38437_at
Day 3 Intra/Day 0 Intra
0.742
4.1247E−03

428
322
Entrez Gene
amyloid beta (A4) precursor protein-binding, family B,
1101_at
Day 7 Intra/Day 0 Intra
0.692
1.6594E−03

member 1 (Fe65)

429
10570
Entrez Gene
dihydropyrimidinase-like 4
39503_s_at
Day 7 Peri/Day 0 Peri
0.693
9.8616E−03

430
6637
Entrez Gene
small nuclear ribonucleoprotein polypeptide G
37337_at
Day 7 Intra/Day 3 Intra
0.693
3.9690E−03

431
8337
Entrez Gene
histone 2, H2aa
286_at
Day 3 Peri/Day 3 Control
0.693
7.8013E−03

432
6193
Entrez Gene
ribosomal protein S5
32437_at
Day 3 Peri/Day 3 Extra
0.693
1.4564E−03

32437_at
Day 7 Peri/Day 0 Peri
0.740
3.6964E−03

32437_at
Day 3 Peri/Day 0 Peri
0.808
6.6422E−03

433
23492
Entrez Gene
chromobox homolog 7
36894_at
Day 3 Peri/Day 3 Control
0.693
8.8784E−03

36894_at
Day 3 Peri/Day 0 Peri
0.742
1.6692E−03

36894_at
Day 7 Peri/Day 0 Peri
0.742
3.4050E−03

434
4809
Entrez Gene
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
41746_at
Day 3 Peri/Day 3 Control
0.693
5.4886E−03

41746_at
Day 3 Peri/Day 0 Peri
0.830
6.1703E−03

435
889
Entrez Gene
KRIT1, ankyrin repeat containing
34031_i_at
Day 3 Intra/Day 3 Peri
0.694
4.9207E−03

436
79090
Entrez Gene
trafficking protein particle complex 6A
36529_at
Day 3 Peri/Day 0 Peri
0.694
6.8032E−03

437
328
Entrez Gene
APEX nuclease (multifunctional DNA repair enzyme) 1
2025_s_at
Day 3 Peri/Day 3 Control
0.695
4.9002E−03

2025_s_at
Day 3 Peri/Day 3 Extra
0.746
9.3963E−03

438
84525
Entrez Gene
homeodomain-only protein
39698_at
Day 7 Peri/Day 0 Peri
0.695
8.7289E−03

439
2549
Entrez Gene
GRB2-associated binding protein 1
33997_at
Day 7 Intra/Day 0 Intra
0.695
2.4091E−04

33997_at
Day 3 Intra/Day 0 Intra
0.710
2.0825E−03

33997_at
Day 0 Peri/Day 0 Intra
0.731
4.0375E−03

440
533
Entrez Gene
ATPase, H+ transporting, lysosomal 21 kDa, V0 subunit
36167_at
Day 7 Peri/Day 7 Control
0.696
9.2513E−03

c″

441
4717
Entrez Gene
NADH dehydrogenase (ubiquinone) 1, subcomplex
38485_at
Day 3 Peri/Day 3 Extra
0.696
2.0589E−03

unknown, 1, 6 kDa

442
23385
Entrez Gene
nicastrin
34835_at
Day 3 Peri/Day 3 Extra
0.696
1.6857E−03

34835_at
Day 3 Peri/Day 3 Intra
0.790
4.8084E−03

443
23125
Entrez Gene
calmodulin binding transcription activator 2
41421_at
Day 7 Intra/Day 0 Intra
0.696
8.6760E−03

444
2926
Entrez Gene
G-rich RNA sequence binding factor 1
32595_at
Day 7 Intra/Day 7 Extra
0.696
6.0979E−03

445
4678
Entrez Gene
nuclear autoantigenic sperm protein (histone-binding)
33255_at
Day 3 Peri/Day 3 Control
0.696
9.0975E−03

446
1847
Entrez Gene
dual specificity phosphatase 5
529_at
Day 7 Peri/Day 7 Extra
0.697
3.7478E−03

447
22849
Entrez Gene
cytoplasmic polyadenylation element binding protein 3
34931_at
Day 3 Intra/Day 0 Intra
0.697
6.8691E−03

448
10106
Entrez Gene
CTD (carboxy-terminal domain, RNA polymerase II,
41202_s_at
Day 3 Intra/Day 0 Intra
0.698
3.5449E−03

polypeptide A) small phosphatase 2

449
57017
Entrez Gene
chromosome 16 open reading frame 49
34810_at
Day 7 Peri/Day 7 Control
0.700
1.2592E−03

34810_at
Day 7 Peri/Day 0 Peri
0.810
4.2261E−03

450
10329
Entrez Gene
transmembrane protein 5
37445_at
Day 3 Intra/Day 3 Extra
0.700
2.4850E−03

451
26959
Entrez Gene
HMG-box transcription factor 1
39809_at
Day 3 Intra/Day 0 Intra
0.701
9.4669E−03

452
539
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F1
37029_at
Day 3 Peri/Day 3 Intra
0.701
5.7342E−03

complex, O subunit (oligomycin sensitivity conferring
37029_at
Day 7 Intra/Day 7 Control
0.784
7.2352E−03

protein)

453
10542
Entrez Gene
hepatitis B virus x interacting protein
38054_at
Day 3 Peri/Day 3 Control
0.704
9.1709E−03

38054_at
Day 7 Intra/Day 7 Extra
0.782
3.3831E−03

454
8624
Entrez Gene
Down syndrome critical region gene 2
36088_at
Day 7 Intra/Day 3 Intra
0.704
8.0554E−03

455
694
Entrez Gene
B-cell translocation gene 1, anti-proliferative
37294_at
Day 3 Peri/Day 3 Extra
0.704
5.5679E−03

456
5431
Entrez Gene
polymerase (RNA) II (DNA directed) polypeptide B,
39746_at
Day 7 Intra/Day 7 Extra
0.705
2.3347E−03

140 kDa

457
4174
Entrez Gene
MCM5 minichromosome maintenance deficient 5, cell
982_at
Day 7 Peri/Day 3 Peri
0.706
4.9235E−04

division cycle 46 (S. cerevisiae)

458
10278
Entrez Gene
embryonal Fyn-associated substrate
33883_at
Day 7 Peri/Day 0 Peri
0.706
2.0000E−05

33883_at
Day 3 Peri/Day 0 Peri
0.718
6.1275E−04

459
593
Entrez Gene
branched chain keto acid dehydrogenase E1, alpha
37704_at
Day 3 Peri/Day 3 Control
0.707
1.4726E−03

polypeptide (maple syrup urine disease)
37704_at
Day 3 Peri/Day 3 Extra
0.720
1.7216E−03

460
4357
Entrez Gene
mercaptopyruvate sulfurtransferase
36124_at
Day 7 Peri/Day 0 Peri
0.707
7.1338E−04

461
3727
Entrez Gene
jun D proto-oncogene
41483_s_at
Day 7 Peri/Day 0 Peri
0.707
9.7391E−03

462
51635
Entrez Gene
dehydrogenase/reductase (SDR family) member 7
39814_s_at
Day 3 Peri/Day 3 Extra
0.708
6.9810E−03

39814_s_at
Day 3 Peri/Day 3 Intra
0.740
6.8403E−03

463
22870
Entrez Gene
SAPS domain family, member 1
36862_at
Day 3 Peri/Day 3 Control
0.709
6.5040E−03

464
22882
Entrez Gene
zinc fingers and homeoboxes 2
41503_at
Day 3 Peri/Day 0 Peri
0.709
9.7700E−05

41503_at
Day 7 Intra/Day 7 Peri
0.750
6.4066E−03

41503_at
Day 7 Peri/Day 0 Peri
0.830
5.9812E−03

465
613
Entrez Gene
breakpoint cluster region
34679_at
Day 3 Peri/Day 3 Extra
0.709
4.4827E−03

466
7150
Entrez Gene
topoisomerase (DNA) I
1030_s_at
Day 7 Peri/Day 7 Extra
0.711
1.5853E−03

467
1329
Entrez Gene
cytochrome c oxidase subunit Vb
39921_at
Day 3 Peri/Day 3 Extra
0.711
8.1965E−03

39921_at
Day 7 Intra/Day 7 Control
0.718
5.7364E−03

468
51020
Entrez Gene
HD domain containing 2
34359_at
Day 7 Intra/Day 0 Intra
0.712
2.4876E−03

34359_at
Day 7 Intra/Day 7 Extra
0.777
2.8509E−03

469
6888
Entrez Gene
transaldolase 1
37311_at
Day 3 Peri/Day 3 Extra
0.713
2.9353E−04

470
3184
Entrez Gene
heterogeneous nuclear ribonucleoprotein D (AU-rich
38016_at
Day 0 Peri/Day 0 Intra
0.714
4.2703E−03

element RNA binding protein 1, 37 kDa)

471
6050
Entrez Gene
ribonuclease/angiogenin inhibitor 1
36187_at
Day 3 Peri/Day 3 Extra
0.715
1.3879E−03

36187_at
Day 3 Peri/Day 3 Control
0.730
5.3879E−03

472
2064
Entrez Gene
v-erb-b2 erythroblastic leukemia viral oncogene
33218_at
Day 3 Peri/Day 0 Peri
0.718
4.9044E−04

homolog 2, neuro/glioblastoma derived oncogene
33218_at
Day 7 Peri/Day 0 Peri
0.740
6.2999E−04

homolog (avian)

473
3054
Entrez Gene
host cell factor C1 (VP16-accessory protein)
37910_at
Day 0 Intra/Day 0 Peri
0.718
6.3341E−03

474
79026
Entrez Gene
AHNAK nucleoprotein (desmoyokin)
37027_at
Day 7 Intra/Day 0 Intra
0.718
8.1471E−03

37027_at
Day 7 Peri/Day 0 Peri
0.748
8.8700E−05

37027_at
Day 3 Peri/Day 0 Peri
0.780
3.1374E−04

475
U77948
GenBank
general transcription factor II, i /// general transcription
35450_s_at
Day 0 Peri/Day 0 Control
0.718
8.5556E−03

factor II, i, pseudogene 1

476
949
Entrez Gene
scavenger receptor class B, member 1
41200_at
Day 7 Peri/Day 0 Peri
0.720
1.3768E−03

41200_at
Day 3 Peri/Day 0 Peri
0.721
1.6250E−03

477
1917
Entrez Gene
eukaryotic translation elongation factor 1 alpha 2
35174_i_at
Day 7 Peri/Day 0 Peri
0.720
6.7372E−04

478
6205
Entrez Gene
ribosomal protein S11
32330_at
Day 7 Peri/Day 0 Peri
0.721
3.3215E−03

479
10611
Entrez Gene
PDZ and LIM domain 5
37366_at
Day 3 Intra/Day 3 Extra
0.722
2.3752E−03

480
HG1614-HT161
The Institute for
—
954_s_at
Day 7 Peri/Day 7 Control
0.722
8.4646E−03

Genomic Research

954_s_at
Day 7 Peri/Day 7 Intra
0.747
1.0730E−03

481
79095
Entrez Gene
chromosome 9 open reading frame 16
41047_at
Day 3 Peri/Day 0 Peri
0.725
5.9374E−03

482
9813
Entrez Gene
KIAA0494
41830_at
Day 3 Intra/Day 0 Intra
0.725
3.4757E−03

483
22924
Entrez Gene
microtubule-associated protein, RP/EB family, member 3
40825_at
Day 7 Peri/Day 0 Peri
0.725
1.1882E−03

40825_at
Day 3 Peri/Day 0 Peri
0.765
2.4008E−03

484
26578
Entrez Gene
osteoclast stimulating factor 1
467_at
Day 7 Peri/Day 7 Extra
0.725
7.2710E−03

485
1347
Entrez Gene
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)
41760_at
Day 3 Peri/Day 3 Extra
0.726
1.4279E−03

486
3615
Entrez Gene
IMP (inosine monophosphate) dehydrogenase 2
36624_at
Day 3 Peri/Day 3 Extra
0.726
5.8955E−03

36624_at
Day 7 Peri/Day 0 Peri
0.740
8.1540E−04

487
1981
Entrez Gene
eukaryotic translation initiation factor 4 gamma, 1
32844_at
Day 7 Peri/Day 0 Peri
0.727
9.4700E−03

488
22934
Entrez Gene
ribose 5-phosphate isomerase A (ribose 5-phosphate
38036_at
Day 0 Peri/Day 0 Intra
0.729
4.9732E−03

epimerase)

489
26100
Entrez Gene
WIPI49-like protein 2
33392_at
Day 3 Intra/Day 3 Extra
0.731
6.9435E−03

490
11311
Entrez Gene
vacuolar protein sorting 45A (yeast)
35779_at
Day 0 Peri/Day 0 Intra
0.731
7.1397E−03

491
3916
Entrez Gene
lysosomal-associated membrane protein 1
39758_f_at
Day 3 Peri/Day 3 Extra
0.732
1.6743E−03

492
23020
Entrez Gene
activating signal cointegrator 1 complex subunit 3-like 1
41224_at
Day 3 Peri/Day 3 Extra
0.732
7.2017E−03

493
10473
Entrez Gene
high mobility group nucleosomal binding domain 4
35738_at
Day 3 Peri/Day 3 Control
0.732
4.8156E−03

494
10075
Entrez Gene
HECT, UBA and WWE domain containing 1
34374_g_at
Day 0 Intra/Day 0 Peri
0.733
2.9867E−03

34372_at
Day 3 Peri/Day 0 Peri
0.802
9.1907E−03

495
6812
Entrez Gene
syntaxin binding protein 1
33942_s_at
Day 3 Peri/Day 3 Extra
0.734
2.7323E−03

496
23511
Entrez Gene
nucleoporin 188 kDa
32644_at
Day 3 Peri/Day 3 Extra
0.735
1.7224E−03

497
HG2238HT232-
The Institute for
—
329_s_at
Day 3 Peri/Day 0 Peri
0.736
9.9413E−03

Genomic Research

498
283638
Entrez Gene
KIAA0284
38592_s_at
Day 3 Peri/Day 3 Extra
0.736
1.6693E−03

38592_s_at
Day 3 Peri/Day 3 Control
0.788
5.7373E−03

499
30968
Entrez Gene
stomatin (EPB72)-like 2
34380_at
Day 3 Peri/Day 3 Extra
0.736
6.0626E−03

500
23259
Entrez Gene
DDHD domain containing 2
35177_at
Day 7 Intra/Day 0 Intra
0.736
6.5771E−03

501
10634
Entrez Gene
growth arrest-specific 2 like 1
31874_at
Day 7 Peri/Day 0 Peri
0.737
7.5700E−05

31874_at
Day 3 Peri/Day 0 Peri
0.791
1.9327E−03

502
3420
Entrez Gene
isocitrate dehydrogenase 3 (NAD+) beta
40111_g_at
Day 3 Peri/Day 3 Extra
0.737
9.0628E−03

503
10424
Entrez Gene
progesterone receptor membrane component 2
38821_at
Day 7 Peri/Day 0 Peri
0.736
3.9496E−03

38821_at
Day 3 Peri/Day 0 Peri
0.746
7.1002E−03

504
8531
Entrez Gene
cold shock domain protein A
39839_at
Day 7 Peri/Day 0 Peri
0.738
8.5534E−03

505
5439
Entrez Gene
polymerase (RNA) II (DNA directed) polypeptide J,
1486_at
Day 7 Peri/Day 0 Peri
0.740
2.7928E−03

13.3 kDa
1486_at
Day 7 Peri/Day 3 Peri
0.772
1.7983E−03

506
10929
Entrez Gene
Splicing factor, arginine/serine-rich, 46 kD
32038_s_at
Day 3 Peri/Day 3 Control
0.740
6.3052E−03

507
6227
Entrez Gene
ribosomal protein S21
32744_at
Day 7 Peri/Day 0 Peri
0.740
7.2902E−03

508
6169
Entrez Gene
ribosomal protein L38
34085_at
Day 7 Peri/Day 0 Peri
0.743
6.3557E−03

509
51304
Entrez Gene
zinc finger, DHHC-type containing 3
39751_at
Day 3 Intra/Day 3 Extra
0.744
7.7468E−03

510
6218
Entrez Gene
ribosomal protein S17
34592_at
Day 7 Peri/Day 0 Peri
0.745
2.8146E−03

511
9540
Entrez Gene
tumor protein p53 inducible protein 3
36079_at
Day 3 Peri/Day 3 Intra
0.746
5.1335E−03

512
1327
Entrez Gene
cytochrome c oxidase subunit IV isoform 1
39027_at
Day 3 Peri/Day 3 Extra
0.746
6.3689E−03

513
10541
Entrez Gene
acidic (leucine-rich) nuclear phosphoprotein 32 family,
38479_at
Day 7 Intra/Day 7 Extra
0.747
1.6161E−03

member B

514
3030
Entrez Gene
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-
36952_at
Day 3 Peri/Day 3 Extra
0.750
6.1291E−03

Coenzyme A thiolase/enoyl-Coenzyme A hydratase
36952_at
Day 0 Peri/Day 0 Control
0.835
2.4582E−03

(trifunctional protein), alpha subunit

515
23379
Entrez Gene
KIAA0947 protein
41595_at
Day 7 Intra/Day 7 Extra
0.751
2.7370E−03

516
3032
Entrez Gene
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-
39741_at
Day 3 Peri/Day 3 Extra
0.752
2.0159E−03

Coenzyme A thiolase/enoyl-Coenzyme A hydratase

(trifunctional protein), beta subunit

517
5223
Entrez Gene
phosphoglycerate mutase 1 (brain)
41221_at
Day 3 Peri/Day 3 Extra
0.752
1.6814E−03

518
10638
Entrez Gene
S-phase response (cyclin-related)
1685_at
Day 3 Peri/Day 0 Peri
0.754
1.2093E−03

519
9215
Entrez Gene
like-glycosyltransferase
41346_at
Day 3 Intra/Day 0 Intra
0.754
4.1376E−03

520
10572
Entrez Gene
CD27-binding (Siva) protein
39020_at
Day 3 Peri/Day 3 Control
0.754
9.5129E−03

521
10241
Entrez Gene
nuclear domain 10 protein
40063_at
Day 3 Intra/Day 0 Intra
0.755
7.6513E−03

522
162427
Entrez Gene
hypothetical protein LOC162427
38423_at
Day 0 Peri/Day 0 Control
0.755
7.1257E−03

38423_at
Day 3 Peri/Day 0 Peri
0.845
2.2722E−03

38423_at
Day 7 Peri/Day 0 Peri
0.848
1.7317E−03

523
10036
Entrez Gene
chromatin assembly factor 1, subunit A (p150)
32589_at
Day 7 Peri/Day 7 Extra
0.756
2.8970E−03

524
6202
Entrez Gene
ribosomal protein S8
31583_at
Day 7 Peri/Day 0 Peri
0.756
8.6210E−03

525
55218
Entrez Gene
chromosome 14 open reading frame 114
35283_at
Day 0 Peri/Day 0 Control
0.759
7.7904E−04

526
1955
Entrez Gene
EGF-like-domain, multiple 5
36488_at
Day 3 Intra/Day 0 Intra
0.759
7.4685E−03

527
9724
Entrez Gene
UTP14, U3 small nucleolar ribonucleoprotein, homolog
39405_at
Day 0 Peri/Day 0 Intra
0.760
3.9078E−03

C (yeast)

528
26003
Entrez Gene
golgi reassembly stacking protein 2, 55 kDa
35805_at
Day 3 Peri/Day 0 Peri
0.761
2.3291E−04

35805_at
Day 7 Peri/Day 0 Peri
0.770
2.6315E−03

529
56829
Entrez Gene
zinc finger CCCH-type, antiviral 1
35682_at
Day 3 Peri/Day 3 Control
0.761
2.0789E−04

530
4601
Entrez Gene
MAX interactor 1
39072_at
Day 3 Intra/Day 0 Intra
0.762
4.0454E−03

654_at
Day 7 Peri/Day 0 Peri
0.783
5.2959E−03

39072_at
Day 3 Peri/Day 0 Peri
0.839
6.8595E−03

531
6293
Entrez Gene
vacuolar protein sorting 52 (yeast)
32658_at
Day 0 Peri/Day 0 Control
0.762
7.4217E−03

32658_at
Day 7 Peri/Day 0 Peri
0.858
6.8088E−03

532
1998
Entrez Gene
E74-like factor 2 (ets domain transcription factor)
507_s_at
Day 7 Intra/Day 0 Intra
0.763
4.9954E−03

533
10067
Entrez Gene
secretory carrier membrane protein 3
32799_at
Day 7 Peri/Day 0 Peri
0.763
8.9346E−03

534
5437
Entrez Gene
polymerase (RNA) II (DNA directed) polypeptide H
35631_at
Day 3 Peri/Day 3 Extra
0.764
7.2269E−03

35631_at
Day 3 Peri/Day 3 Intra
0.772
5.4217E−03

535
6203
Entrez Gene
ribosomal protein S9
31511_at
Day 7 Peri/Day 0 Peri
0.764
7.8708E−03

536
55744
Entnez Gene
hypothetical protein FLJ10803
37610_at
Day 3 Peri/Day 3 Extra
0.764
2.5200E−03

537
7693
Entrez Gene
zinc finger protein 134 (clone pHZ-15)
36295_at
Day 3 Intra/Day 0 Intra
0.764
9.8397E−03

538
5036
Entrez Gene
proliferation-associated 2G4, 38 kDa
41600_at
Day 7 Peri/Day 0 Peri
0.765
6.9426E−03

539
9249
Entrez Gene
dehydrogenase/reductase (SDR family) member 3
40782_at
Day 3 Peri/Day 0 Peri
0.765
6.4510E−03

540
1337
Entrez Gene
cytochrome c oxidase subunit Via polypeptide 1
41206_r_at
Day 7 Peri/Day 0 Peri
0.766
1.7769E−03

541
23623
Entrez Gene
RUN and SH3 domain containing 1
34264_at
Day 3 Peri/Day 3 Intra
0.768
9.1280E−03

542
8890
Entrez Gene
eukaryotic translation initiation factor 2B, subunit 4
32659_at
Day 3 Peri/Day 3 Control
0.768
8.3725E−03

delta, 67 kDa

543
203069
Entrez Gene
R3H domain and coiled-coil containing 1
35156_at
Day 7 Peri/Day 0 Peri
0.769
8.4083E−03

544
7529
Entrez Gene
tyrosine 3-monooxygenase/tryptophan 5-
32324_at
Day 3 Peri/ Day 3 Extra
0.769
5.4500E−03

monooxygenase activation protein, beta polypeptide

545
23294
Entrez Gene
ankyrin repeat and sterile alpha motif domain containing 1
40971_at
Day 3 Intra/Day 0 Intra
0.769
7.4093E−03

40971_at
Day 3 Peri/Day 0 Peri
0.796
3.4853E−03

546
29
Entrez Gene
active BCR-related gene
39058_at
Day 3 Peri/Day 3 Control
0.771
7.8298E−03

39058_at
Day 3 Peri/Day 3 Extra
0.796
8.8684E−03

547
1937
Entrez Gene
eukaryotic translation elongation factor 1 gamma
1676_s_at
Day 7 Peri/Day 0 Peri
0.771
8.5875E−03

548
5636
Entrez Gene
phosphoribosyl pyrophosphate synthetase-associated
41853_at
Day 3 Intra/Day 3 Extra
0.772
9.6928E−03

protein 2

549
147179
Entrez Gene
WIRE protein
40787_at
Day 3 Peri/Day 0 Peri
0.772
8.6910E−04

550
9703
Entrez Gene
KIAA0100 gene product
39783_at
Day 0 Intra/Day 0 Peri
0.773
4.2046E−03

551
10294
Entrez Gene
DnaJ (Hsp40) homolog, subfamily A, member 2
34201_at
Day 3 Intra/Day 0 Intra
0.775
2.1191E−03

552
9741
Entrez Gene
lysosomal-associated protein transmembrane 4 alpha
39019_at
Day 3 Intra/Day 0 Intra
0.776
6.0768E−03

39019_at
Day 7 Intra/Day 0 Intra
0.815
9.6992E−03

553
8480
Entrez Gene
RAE1 RNA export 1 homolog (S. pombe)
32757_at
Day 3 Peri/Day 3 Extra
0.778
1.2850E−03

32758_g_at
Day 7 Peri/Day 7 Intra
0.786
2.2519E−03

554
10556
Entrez Gene
ribonuclease P/MRP 30 kDa subunit
39702_at
Day 3 Intra/Day 3 Extra
0.778
8.7433E−03

555
9562
Entrez Gene
multiple inositol polyphosphate histidine phosphatase, 1
38325_at
Day 3 Intra/Day 3 Extra
0.779
8.9541E−03

556
9528
Entrez Gene
transmembrane protein 59
39033_at
Day 3 Intra/Day 3 Control
0.779
6.9035E−03

39033_at
Day 3 Intra/Day 0 Intra
0.787
2.6172E−04

557
5326
Entrez Gene
pleiomorphic adenoma gene-like 2
40061_at
Day 3 Intra/Day 3 Peri
0.779
7.8774E−03

558
3163
Entrez Gene
heme oxygenase (decycling) 2
37916_at
Day 7 Peri/Day 3 Peri
0.781
9.4119E−03

559
22864
Entrez Gene
KIAA1002 protein
41366_at
Day 3 Peri/Day 0 Peri
0.781
8.7647E−03

560
23307
Entrez Gene
KIAA0674
31826_at
Day 0 Peri/Day 0 Control
0.783
2.4933E−03

561
670
Entrez Gene
biphenyl hydrolase-like (serine hydrolase; breast
40912_s_at
Day 0 Intra/Day 0 Control
0.784
7.7779E−03

epithelial mucin-associated antigen)

562
9903
Entrez Gene
kelch-like 21 (Drosophila)
37230_at
Day 3 Peri/Day 0 Peri
0.786
5.6275E−03

37230_at
Day 7 Peri/Day 0 Peri
0.812
4.4808E−03

563
5236
Entrez Gene
phosphoglucomutase 1
32210_at
Day 3 Peri/Day 0 Peri
0.789
7.7233E−03

564
51780
Entrez Gene
jumoriji domain containing 1B
33870_at
Day 3 Intra/Day 0 Intra
0.789
6.0617E−03

565
2975
Entrez Gene
general transcription factor IIIC, polypeptide 1, alpha
35671_at
Day 7 Peri/Day 0 Peri
0.791
3.1660E−03

220 kDa

566
10956
Entrez Gene
amplified in osteosarcoma
36996_at
Day 7 Peri/Day 0 Peri
0.791
9.0785E−03

36996_at
Day 3 Peri/Day 0 Peri
0.818
6.2854E−03

567
1201
Entrez Gene
ceroid-lipofuscinosis, neuronal 3, juvenile (Batten,
497_at
Day 3 Peri/Day 3 Control
0.792
5.8473E−03

Spielmeyer-Vogt disease)

568
56270
Entrez Gene
WDR45-like
39185_at
Day 3 Intra/Day 3 Control
0.792
6.7923E−03

569
527
Entrez Gene
ATPase, H+ transporting, lysosomal 16 kDa, V0 subunit c
36994_at
Day 7 Peri/Day 0 Peri
0.794
8.6116E−03

570
8720
Entrez Gene
membrane-bound transcription factor peptidase, site 1
36964_at
Day 3 Peri/Day 0 Peri
0.795
9.8019E−03

571
3151
Entrez Gene
high-mobility group nucleosomal binding domain 2
41231_f_at
Day 3 Peri/Day 3 Extra
0.796
7.6383E−04

41231_f_at
Day 3 Peri/Day 3 Intra
0.827
4.3201E−03

572
286440
Entrez Gene
hypothetical protein LOC286440
41655_at
Day 3 Peri/Day 0 Peri
0.796
8.4134E−03

573
6136
Entrez Gene
ribosomal protein L12
33668_at
Day 7 Peri/Day 0 Peri
0.797
2.3409E−03

574
79073
Entrez Gene
hypothetical protein MGC5508
39693_at
Day 3 Intra/Day 3 Extra
0.797
7.6719E−03

575
445
Entrez Gene
argininosuccinate synthetase
40541_at
Day 7 Peri/Day 3 Peri
0.799
7.5623E−03

576
11224
Entrez Gene
ribosomal protein L35
41765_at
Day 7 Peri/Day 0 Peri
0.800
6.9298E−03

577
11258
Entrez Gene
dynactin 3 (p22)
40410_at
Day 3 Peri/Day 3 Control
0.808
6.4549E−03

578
4779
Entrez Gene
nuclear factor (erythroid-derived 2)-like 1
38439_at
Day 7 Peri/Day 0 Peri
0.811
5.5209E−03

579
149603
Entrez Gene
ring finger protein 187
39722_at
Day 3 Peri/Day 0 Peri
0.812
7.5346E−03

580
8818
Entrez Gene
dolichyl-phosphate mannosyltransferase polypeptide 2,
38726_at
Day 7 Peri/Day 3 Peri
0.814
3.7920E−03

regulatory subunit

581
823
Entrez Gene
calpain 1, (mu/l) large subunit
33908_at
Day 7 Peri/Day 3 Peri
0.815
9.2186E−03

582
5438
Entrez Gene
polymerase (RNA) II (DNA directed) polypeptide I,
34828_at
Day 0 Peri/Day 0 Control
0.816
8.6878E−03

14.5 kDa

583
6720
Entrez Gene
sterol regulatory element binding transcription factor 1
32135_at
Day 3 Peri/Day 0 Peri
0.819
6.4366E−03

584
23633
Entrez Gene
Karyopherin alpha 6 (importin alpha 7)
40275_at
Day 3 Peri/Day 0 Peri
0.824
1.6981E−03

40275_at
Day 7 Peri/Day 0 Peri
0.847
5.5244E−03

585
7534
Entrez Gene
tyrosine 3-monooxygenase/tryptophan 5-
1235_at
Day 3 Peri/Day 3 Extra
0.824
9.9973E−03

monooxygenase activation protein, zeta polypeptide
1235_at
Day 3 Peri/Day 3 Intra
0.853
7.0175E−03

586
23481
Entrez Gene
pescadillo homolog 1, containing BRCT domain
41869_at
Day 7 Peri/Day 0 Peri
0.831
9.3885E−03

(zebrafish)

587
369
Entrez Gene
v-raf murine sarcoma 3611 viral oncogene homolog
1706_at
Day 7 Intra/Day 3 Intra
0.832
4.3502E−04

588
23
Entrez Gene
ATP-binding cassette, sub-family F (GCN20), member 1
39141_at
Day 7 Intra/Day 3 Intra
0.837
5.3611E−03

589
25966
Entrez Gene
chromosome 21 open reading frame 25
32107_at
Day 7 Intra/Day 7 Extra
0.845
5.8404E−03

590
23644
Entrez Gene
autoantigen
36670_at
Day 3 Intra/Day 0 Intra
0.866
7.3351E−03

TABLE 2

Diagnostic Down

Public

Gene ID
Identifier
Data Source
Gene Name

1
4250
Entrez Gene
secretoglobin, family 2A, member 2

3
10647
Entrez Gene
secretoglobin, family 1D, member 2

5
2167
Entrez Gene
fatty acid binding protein 4, adipocyte

8
9415
Entrez Gene
fatty acid desaturase 2

11
553168
Entrez Gene
chromosome 1 open reading frame 68

13
125
Entrez Gene
alcohol dehydrogenase IB (class I), beta polypeptide

14
3205
Entrez Gene
homeo box A9

15
7136
Entrez Gene
troponin I type 2 (skeletal, fast)

17
6210
Entrez Gene
ribosomal protein S15a

18
7123
Entrez Gene
C-type lectin domain family 3, member B

20
AB011538
GenBank
CDNA clone IMAGE: 5922621

21
3131
Entrez Gene
Hepatic leukemia factor

22
M57951
GenBank
UDP glucuronosyltransferase 1 family, polypeptide A10

/// UDP glucuronosyltransferase 1 family, polypeptide

A8 /// UDP glucuronosyltransferase 1 fami

24
2053
Entrez Gene
epoxide hydrolase 2, cytoplasmic

26
5271
Entrez Gene
serpin peptidase inhibitor, clade B (ovalbumin), member 8

28
10781
Entrez Gene
zinc finger protein 266

29
4128
Entrez Gene
monoamine oxidase A

31
8483
Entrez Gene
cartilage intermediate layer protein, nucleotide

pyrophosphohydrolase

34
10458
Entrez Gene
BAI1-associated protein 2

36
2273
Entrez Gene
four and a half LIM domains 1

37
23016
Entrez Gene
exosome component 7

38
23352
Entrez Gene
retinoblastoma-associated factor 600

39
7138
Entrez Gene
troponin T type 1 (skeletal, slow)

42
10521
Entrez Gene
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

43
8710
Entrez Gene
serpin peptidase inhibitor, clade B (ovalbumin), member 7

44
2194
Entrez Gene
fatty acid synthase

45
3202
Entrez Gene
homeo box A5

46
54
Entrez Gene
acid phosphatase 5, tartrate resistant

49
63928
Entrez Gene
hepatocellular carcinoma antigen gene 520

50
5055
Entrez Gene
serpin peptidase inhibitor, clade B (ovalbumin), member 2

51
5354
Entrez Gene
proteolipid protein 1 (Pelizaeus-Merzbacher disease,

spastic paraplegia 2, uncomplicated)

52
642
Entrez Gene
bleomycin hydrolase

53
10443
Entrez Gene
Hypothetical gene CG012

54
224
Entrez Gene
aldehyde dehydrogenase 3 family, member A2

55
90634
Entrez Gene
hypothetical gene CG018

56
1675
Entrez Gene
D component of complement (adipsin)

57
23242
Entrez Gene
cordon-bleu homolog (mouse)

58
10158
Entrez Gene
PDZK1 interacting protein 1

59
10001
Entrez Gene
mediator of RNA polymerase II transcription, subunit 6

homolog (yeast)

60
97
Entrez Gene
acylphosphatase 1, erythrocyte (common) type

63
51097
Entrez Gene
saccharopine dehydrogenase (putative)

64
2217
Entrez Gene
Fc fragment of IgG, receptor, transporter, alpha

65
1983
Entrez Gene
eukaryotic translation initiation factor 5

66
51601
Entrez Gene
lipoyltransferase 1

70
2618
Entrez Gene
phosphoribosylglycinamide formyltransferase,

phosphoribosylglycinamide synthetase,

phosphoribosylaminoimidazole synthetase

71
HG3570-
The Institute for
—

HT377
Genomic Research

72
53335
Entrez Gene
B-cell CLL/lymphoma 11A (zinc finger protein)

74
8906
Entrez Gene
adaptor-related protein complex 1, gamma 2 subunit

77
9524
Entrez Gene
glycoprotein, synaptic 2

78
91137
Entrez Gene
hypothetical protein BC017169

79
56288
Entrez Gene
par-3 partitioning defective 3 homolog (C. elegans)

80
26154
Entrez Gene
ATP-binding cassette, sub-family A (ABC1), member 12

81
260294
Entrez Gene
Williams Beuren syndrome chromosome region 20C

82
1410
Entrez Gene
crystallin, alpha B

83
131544
Entrez Gene
hypothetical protein DKFZp667G2110

84
10733
Entrez Gene
polo-like kinase 4 (Drosophila)

86
10181
Entrez Gene
RNA binding motif protein 5

90
6924
Entrez Gene
Transcription elongation factor B (SIII), polypeptide 3

(110 kDa, elongin A)

93
1152
Entrez Gene
creatine kinase, brain

94
10450
Entrez Gene
peptidylprolyl isomerase E (cyclophilin E)

95
HG1112-
The Institute for
—

HT111
Genomic Research

97
4129
Entrez Gene
monoamine oxidase B

99
10314
Entrez Gene
LanC lantibiotic synthetase component C-like 1

(bacterial)

101
8532
Entrez Gene
carboxypeptidase Z

102
6038
Entrez Gene
ribonuclease, RNase A family, 4

103
10924
Entrez Gene
sphingomyelin phosphodiesterase, acid-like 3A

106
8634
Entrez Gene
RNA terminal phosphate cyclase domain 1

107
4163
Entrez Gene
mutated in colorectal cancers

108
7262
Entrez Gene
pleckstrin homology-like domain, family A, member 2

109
26039
Entrez Gene
synovial sarcoma translocation gene on chromosome

18-like 1

110
1525
Entrez Gene
coxsackie virus and adenovirus receptor

112
11072
Entrez Gene
dual specificity phosphatase 14

113
6490
Entrez Gene
sliver homolog (mouse)

115
4176
Entrez Gene
MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)

116
2197
Entrez Gene
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV)

ubiquitously expressed (fox derived); ribosomal protein

S30

118
4898
Entrez Gene
nardilysin (N-arginine dibasic convertase)

119
6662
Entrez Gene
SRY (sex determining region Y)-box 9 (campornelic

dysplasia, autosomal sex-reversal)

120
2114
Entrez Gene
v-ets erythroblastosis virus E26 oncogene homolog 2

(avian)

121
1158
Entrez Gene
creatine kinase, muscle

123
1573
Entrez Gene
cytochrome P450, family 2, subfamily J, polypeptide 2

129
9833
Entrez Gene
maternal embryonic leucine zipper kinase

130
U18300
GenBank
damage-specific DNA binding protein 2, 48 kDa /// LIM

homeobox 3

131
23051
Entrez Gene
zinc fingers and homeoboxes 3

132
51706
Entrez Gene
cytochrome b5 reductase 1

136
2013
Entrez Gene
epithelial membrane protein 2

137
81563
Entrez Gene
chromosome 1 open reading frame 21

138
1638
Entrez Gene
dopachrome tautomerase (dopachrome delta-

isomerase, tyrosine-related protein 2)

141
57613
Entrez Gene
KIAA1467 protein

142
2647
Entrez Gene
biogenesis of lysosome-related organelies complex-1,

subunit 1

144
AF096870
GenBank
tripartite motif-containing 16 /// similar to tripartite motif-

containing 16; estrogen-responsive B box protein

146
4968
Entrez Gene
8-oxoguanine DNA glycosylase

148
4713
Entrez Gene
NADH dehydrogenase (ubiquinone) 1 beta subcomplex,

7, 18 kDa

149
1396
Entrez Gene
cysteine-rich protein 1 (intestinal)

150
771
Entrez Gene
carbonic anhydrase XII

151
55187
Entrez Gene
vacuolar protein sorting 13D (yeast)

152
498
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F1

complex, alpha subunit, isoform 1, cardiac muscle

154
242
Entrez Gene
arachidonate 12-lipoxygenase, 12R type

156
5985
Entrez Gene
replication factor C (activator 1) 5, 36.5 kDa

157
26610
Entrez Gene
elongation protein 4 homolog (S. cerevisiae)

159
5110
Entrez Gene
Protein-L-isoaspartate (D-aspartate) O-

methyltransferase

160
113146
Entrez Gene
chromosome 14 open reading frame 78

165
10124
Entrez Gene
ADP-ribosylation factor-like 4

166
10653
Entrez Gene
serine peptidase inhibitor, Kunitz type, 2

167
10434
Entrez Gene
lysophospholipase I

169
123
Entrez Gene
adipose differentiation-related protein

170
80308
Entrez Gene
Fad1, flavin adenine dinucleotide synthetase, homolog

(yeast)

173
23345
Entrez Gene
spectrin repeat containing, nuclear envelope 1

175
80208
Entrez Gene
hypothetical protein FLJ21439

176
202
Entrez Gene
absent in melanoma 1

178
5268
Entrez Gene
serpin peptidase inhibitor, clade B (ovalbumin), member 5

178
5268
Entrez Gene
serpin peptidese inhibitor, clade B (ovalbumin), member 5

179
1474
Entrez Gene
cystatin E/M

180
9927
Entrez Gene
mitofusin 2

182
2145
Entrez Gene
enhancer of zeste homolog 1 (Drosophila)

183
2959
Entrez Gene
general transcription factor IIB

185
4736
Entrez Gene
ribosomal protein L10a

186
644
Entrez Gene
biliverdin reductase A

187
9665
Entrez Gene
limkain b1

188
3033
Entrez Gene
L-3-hydroxyacyl-Coenzyme A dehydrogenase, short

chain

190
55651
Entrez Gene
nucleolar protein family A, member 2 (H/ACA small

nucleolar RNPs)

191
11336
Entrez Gene
SEC6-like 1 (S. cerevisiae)

192
7009
Entrez Gene
testis enhanced gene transcript (BAX inhibitor 1)

193
23107
Entrez Gene
mitochondrial ribosomal protein S27

194
50
Entrez Gene
aconitase 2, mitochondrial

195
2746
Entrez Gene
glutamate dehydrogenase 1

197
6477
Entrez Gene
Seven in absentia homolog 1 (Drosophila)

198
6166
Entrez Gene
ribosomal protein L36a-like

199
7175
Entrez Gene
translocated promoter region (to activated MET

oncogene)

201
171546
Entrez Gene
chromosome 14 open reading frame 147

202
10553
Entrez Gene
HIV-1 Tat interactive protein 2, 30 kDa

203
115817
Entrez Gene
dehydrogenase/reductase (SDR family) member 1

204
25813
Entrez Gene
sorting and assembly machinery component 50

homolog (S. cerevisiae)

205
25953
Entrez Gene
DKFZP564G2022 protein

206
1212
Entrez Gene
clathrin, light polypeptide (Lcb)

207
1652
Entrez Gene
D-dopachrome tautomerase

208
27335
Entrez Gene
eukaryotic translation initiation factor 3, subunit 12

209
217
Entrez Gene
aldehyde dehydrogenase 2 family (mitochondrial)

210
10049
Entrez Gene
DnaJ (Hsp40) homolog, subfamily B, member 6

212
8623
Entrez Gene
acetylserotonin O-methyltransferase-like

213
169611
Entrez Gene
olfactomedin-like 2A

214
11066
Entrez Gene
U11/U12 snRNP 35K

215
9936
Entrez Gene
CD302 antigen

216
4729
Entrez Gene
NADH dehydrogenase (ubiquinone) flavoprotein 2,

24 kDa

217
987
Entrez Gene
LPS-responsive vesicle trafficking, beach and anchor

containing

218
128
Entrez Gene
alcohol dehydrogenase 5 (class III), chi polypeptide

220
7295
Entrez Gene
thioredoxin

222
10980
Entrez Gene
COP9 constitutive photomorphogenic homolog subunit

6 (Arabidopsis)

223
2621
Entrez Gene
growth arrest-specific 6

224
831
Entrez Gene
calpastatin

228
645
Entrez Gene
biliverdin reductase B (flavin reductase (NADPH))

229
8581
Entrez Gene
lymphocyte antigen 6 complex, locus D

230
AB006780
GenBank
lectin, galectoside-binding, soluble, 3 (galectin 3) ///

galectin-3 internal gene

231
6929
Entrez Gene
transcription factor 3 (E2A immunoglobulin enhancer

binding factors E12/E47)

232
10476
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F0

complex, subunit d

233
7022
Entrez Gene
transcription factor AP-2 gamma (activating enhancer

binding protein 2 gamma)

234
2806
Entrez Gene
glutamic-oxaloacetic transaminase 2, mitochondrial

(aspartate aminotransferase 2)

235
23185
Entrez Gene
La ribonucleoprotein domain family, member 5

237
708
Entrez Gene
complement component 1, q subcomponent binding

protein

238
81875
Entrez Gene
Interferon stimulated exonuclease gene 20 kDa-like 2

239
AI032612
GenBank
enolase 1, (alpha) /// small nuclear ribonucleoprotein

polypeptide F

240
26040
Entrez Gene
SET binding protein 1

241
8673
Entrez Gene
vesicle-associated membrane protein 8 (endobrevin)

243
4255
Entrez Gene
O-6-methylguanine-DNA methyltransferase

245
6249
Entrez Gene
restin (Reed-Steinberg cell-expressed intermediate

filament-associated protein)

246
11188
Entrez Gene
nischarin

248
2547
Entrez Gene
X-ray repair complementing defective repair in Chinese

hamster cells 6 (Ku autoantigen, 70 kDa)

249
545
Entrez Gene
ataxia telangiectasia and Rad3 related

250
4775
Entrez Gene
nuclear factor of activated T-cells, cytoplasmic,

calcineurin-dependent 3

252
4790
Entrez Gene
nuclear factor of kappa light polypeptide gene enhancer

in B-cells 1 (p105)

254
26135
Entrez Gene
SERPINE1 mRNA binding protein 1

255
23234
Entrez Gene
DnaJ (Hsp40) homolog, subfamily C, member 9

257
AI557912
GenBank
translocase of outer mitochondrial membrane 7

homolog (yeast) /// hypothetical protein LOC201725

258
4437
Entrez Gene
mutS homolog 3 (E. coli)

259
3550
Entrez Gene
IK cytokine, down-regulator of HLA II

260
5453
Entrez Gene
POU domain, class 3, transcription factor 1

262
353
Entrez Gene
adenine phosphoribosyltransferase

263
6427
Entrez Gene
splicing factor, arginine/serine-rich 2

265
79703
Entrez Gene
hypothetical protein FLJ22531

266
27292
Entrez Gene
dimethyladenosine transferase

267
54665
Entrez Gene
round spermatid basic protein 1

268
513
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F1

complex, delta subunit

269
AL050091
GenBank
glutamate receptor, ionotropic, N-methyl D-aspartate-

like 1A /// GRINL1A combined protein /// similar to

glutamate receptor, ionotropic, N-methyl D-a

271
9349
Entrez Gene
ribosomal protein L23

273
23090
Entrez Gene
zinc finger protein 423

275
10497
Entrez Gene
unc-13 homolog B (C. elegans)

276
56967
Entrez Gene
chromosome 14 open reading frame 132

276
56967
Entrez Gene
chromosome 14 open reading frame 132

277
8560
Entrez Gene
degenerative spermatocyte homolog 1, lipid desaturase

(Drosophila)

278
10975
Entrez Gene
ubiquinol-cytochrome c reductase, 6.4 kDa subunit

279
10641
Entrez Gene
tumor suppressor candidate 4

280
8663
Entrez Gene
eukaryotic translation initiation factor 3, subunit 8,

110 kDa

281
50717
Entrez Gene
WD repeat domain 42A

282
23392
Entrez Gene
KIAA0368

285
23650
Entrez Gene
tripartite motif-containing 29

286
8665
Entrez Gene
eukaryotic translation initiation factor 3, subunit 5

epsilon, 47 kDa

287
7203
Entrez Gene
chaperonin containing TCP1, subunit 3 (gamma)

290
25797
Entrez Gene
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)

291
5092
Entrez Gene
6-pyruvoyl-tetrahydropterin synthase/dimerization

cofactor of hepatocyte nuclear factor 1 alpha (TCF1)

292
7818
Entrez Gene
death associated protein 3

293
U05861
GenBank
aldo-keto reductase family 1, member C1 (dihydrodiol

dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid

dehydrogenase) /// aldo-keto reductase family

294
23063
Entrez Gene
KIAA0261

295
9529
Entrez Gene
BCL2-associated athanogene 5

296
57147
Entrez Gene
SCY1-like 3 (S. cerevisiae)

298
10289
Entrez Gene
translation factor sui1 homolog

299
9536
Entrez Gene
prostaglandin E synthase

300
22883
Entrez Gene
calsyntenin 1

301
7520
Entrez Gene
X-ray repair complementing defective repair in Chinese

hamster cells 5 (double-strand-break rejoining; Ku

autoantigen, 60 kDa)

303
4928
Entrez Gene
nucleoporin 98 kDa

304
3290
Entrez Gene
hydroxysteroid (11-beta) dehydrogenase 1

305
23351
Entrez Gene
KIAA0323

306
2065
Entrez Gene
v-erb-b2 erythroblastic leukemia viral oncogene

homolog 3 (avian)

307
10217
Entrez Gene
CTD (carboxy-terminal domain, RNA polymerase II,

polypeptide A) small phosphatase-like

308
23658
Entrez Gene
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)

309
W28948
GenBank
Full length insert cDNA YH77E09

311
4681
Entrez Gene
neuroblastoma, suppression of tumorigenicity 1

314
6209
Entrez Gene
ribosomal protein S15

316
8824
Entrez Gene
carboxylesterase 2 (intestine, liver)

317
10961
Entrez Gene
endoplasmic reticulum protein 29

318
7265
Entrez Gene
tetratricopeptide repeat domain 1

321
6128
Entrez Gene
ribosomal protein L6

322
5245
Entrez Gene
prohibitin

323
9296
Entrez Gene
ATPase, H+ transporting, lysosomal 14 kDa, V1 subunit F

324
1340
Entrez Gene
cytochrome c oxidase subunit Vib polypeptide 1

(ubiquitous)

325
1891
Entrez Gene
enoyl Coenzyme A hydratase 1, peroxisomal

326
1632
Entrez Gene
dodecenoyl-Coenzyme A delta isomerase (3,2 trans-

enoyl-Coenzyme A isomerase)

327
1933
Entrez Gene
eukaryotic translation elongation factor 1 beta 2

328
6141
Entrez Gene
ribosomal protein L18

330
6950
Entrez Gene
t-complex 1

331
29760
Entrez Gene
B-cell linker

332
573
Entrez Gene
BCL2-associated athanogene

333
2709
Entrez Gene
gap junction protein, beta 5 (connexin 31.1)

335
11083
Entrez Gene
death associated transcription factor 1

336
10247
Entrez Gene
heat-responsive protein 12

338
899
Entrez Gene
cyclin F

339
HG162-
The Institute for
—

HT3165
Genomic Research

340
6139
Entrez Gene
ribosomal protein L17

341
9521
Entrez Gene
eukaryotic translation elongation factor 1 epsilon 1

342
1054
Entrez Gene
CCAAT/enhancer binding protein (C/EBP), gamma

343
7739
Entrez Gene
zinc finger protein 185 (LIM domain)

344
8664
Entrez Gene
eukaryotic translation initiation factor 3, subunit 7 zeta,

66/67 kDa

345
57418
Entrez Gene
WD repeat domain 18

346
6187
Entrez Gene
ribosomal protein S2

347
11079
Entrez Gene
RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)

348
26211
Entrez Gene
olfactory receptor, family 2, subfamily F, member 1

349
6206
Entrez Gene
ribosomal protein S12

350
9798
Entrez Gene
KIAA0174

351
132556
Entrez Gene
similar to Transcription factor BTF3 homolog 3

353
4070
Entrez Gene
tumor-associated calcium signal transducer 2

354
7152
Entrez Gene
topoisomerase (DNA) I pseudogene 2

355
4615
Entrez Gene
myeloid differentiation primary response gene (88)

357
9377
Entrez Gene
cytochrome c oxidase subunit Va

358
7386
Entrez Gene
ubiquinol-cytochrome c reductase, Rieske iron-sulfur

polypeptide 1

359
4835
Entrez Gene
NAD(P)H dehydrogenase, quinone 2

362
HG1980-
The Institute for
—

HT202
Genomic Research

364
54107
Entrez Gene
polymerase (DNA directed), epsilon 3 (p17 subunit)

366
8192
Entrez Gene
ClpP caseinolytic peptidase, ATP-dependent, proteolytic

subunit homolog (E. coli)

367
51690
Entrez Gene
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)

368
5936
Entrez Gene
RNA binding motif protein 4

369
7004
Entrez Gene
TEA domain family member 4

370
3094
Entrez Gene
histidine triad nucleotide binding protein 1

372
10557
Entrez Gene
ribonuclease P/MRP 38 kDa subunit

373
26156
Entrez Gene
ribosomal L1 domain containing 1

374
6122
Entrez Gene
ribosomal protein L3

375
6176
Entrez Gene
ribosomal protein, large, P1

378
10014
Entrez Gene
histone deacetylase 5

379
10610
Entrez Gene
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)

N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

380
HG662-HT662
The Institute for
—

Genomic Research

381
10694
Entrez Gene
chaperonin containing TCP1, subunit 8 (theta)

383
4856
Entrez Gene
nephroblastoma overexpressed gene

384
9314
Entrez Gene
Kruppel-like factor 4 (gut)

385
4694
Entrez Gene
NADH dehydrogenase (ubiquinone) 1 alpha

subcomplex, 1, 7.5 kDa

386
10904
Entrez Gene
bladder cancer associated protein

388
10682
Entrez Gene
emopamil binding protein (sterol isomerase)

389
8667
Entrez Gene
eukaryotic translation initiation factor 3, subunit 3

gamma, 40 kDa

395
5441
Entrez Gene
polymerase (RNA) II (DNA directed) polypeptide L,

7.6 kDa

396
2146
Entrez Gene
enhancer of zeste homolog 2 (Drosophila)

398
2950
Entrez Gene
glutathione S-transferase pi

401
6156
Entrez Gene
ribosomal protein L30

402
516
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F0

complex, subunit c (subunit 9), isoform 1

403
9128
Entrez Gene
PRP4 pre-mRNA processing factor 4 homolog (yeast)

404
3028
Entrez Gene
hydroxyacyl-Coenzyme A dehydrogenase, type II

405
2961
Entrez Gene
general transcription factor IIE, polypeptide 2, beta

34 kDa

406
10969
Entrez Gene
EBNA1 binding protein 2

407
6748
Entrez Gene
signal sequence receptor, delta (translocon-associated

protein delta)

408
4610
Entrez Gene
v-myc myelocytomatosis viral oncogene homolog 1,

lung carcinoma derived (avian)

410
23075
Entrez Gene
SWAP-70 protein

411
1537
Entrez Gene
cytochrome c-1

412
6768
Entrez Gene
suppression of tumorigenicity 14 (colon carcinoma,

matriptase, epithin)

413
6138
Entrez Gene
ribosomal protein L15

415
64976
Entrez Gene
mitochondrial ribosomal protein L40

416
10420
Entrez Gene
testis-specific kinase 2

417
9759
Entrez Gene
histone deacetylase 4

418
4676
Entrez Gene
nucleosome assembly protein 1-like 4

419
5425
Entrez Gene
polymerase (DNA directed), delta 2, regulatory subunit

50 kDa

420
6390
Entrez Gene
succinate dehydrogenase complex, subunit B, iron

sulfur (Ip)

421
162
Entrez Gene
adaptor-related protein complex 1, beta 1 subunit

423
6749
Entrez Gene
structure specific recognition protein 1

424
4134
Entrez Gene
microtubule-associated protein 4

425
6832
Entrez Gene
suppressor of var1, 3-like 1 (S. cerevisiae)

426
10939
Entrez Gene
AFG3 ATPase family gene 3-like 2 (yeast)

429
10570
Entrez Gene
dihydropyrimidinase-like 4

431
8337
Entrez Gene
histone 2, H2aa

432
6193
Entrez Gene
ribosomal protein S5

433
23492
Entrez Gene
chromobox homolog 7

434
4809
Entrez Gene
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)

434
4809
Entrez Gene
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)

436
79090
Entrez Gene
trafficking protein particle complex 6A

437
328
Entrez Gene
APEX nuclease (multifunctional DNA repair enzyme) 1

438
84525
Entrez Gene
homeodomain-only protein

439
2549
Entrez Gene
GRB2-associated binding protein 1

440
533
Entrez Gene
ATPase, H+ transporting, lysosomal 21 kDa, V0 subunit

c″

441
4717
Entrez Gene
NADH dehydrogenase (ubiquinone) 1, subcomplex

unknown, 1, 6 kDa

442
23385
Entrez Gene
nicastrin

445
4678
Entrez Gene
nuclear autoantigenic sperm protein (histone-binding)

446
1847
Entrez Gene
dual specificity phosphatase 5

449
57017
Entrez Gene
chromosome 16 open reading frame 49

452
539
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F1

complex, O subunit (oligomycin sensitivity conferring

protein)

453
10542
Entrez Gene
hepatitis B virus x interacting protein

455
694
Entrez Gene
B cell translocation gene 1, anti-proliferative

457
4174
Entrez Gene
MCM5 minichromosome maintenance deficient 5, cell

division cycle 46 (S. cerevisiae)

458
10278
Entrez Gene
embryonal Fyn-associated substrate

459
593
Entrez Gene
branched chain keto acid dehydrogenase E1, alpha

polypeptide (maple syrup urine disease)

460
4357
Entrez Gene
mercaptopyruvate sulfurtransferase

461
3727
Entrez Gene
jun D proto-oncogene

462
51635
Entrez Gene
dehydrogenase/reductase (SDR family) member 7

463
22870
Entrez Gene
SAPS domain family, member 1

464
22882
Entrez Gene
zinc fingers and homeoboxes 2

465
613
Entrez Gene
breakpoint cluster region

466
7150
Entrez Gene
topoisomerase (DNA) I

467
1329
Entrez Gene
cytochrome c oxidase subunit Vb

469
6888
Entrez Gene
transaldolase 1

470
3184
Entrez Gene
heterogeneous nuclear ribonucleoprotein D (AU-rich

element RNA binding protein 1, 37 kDa)

471
6050
Entrez Gene
ribonuclease/angiogenin inhibitor 1

472
2064
Entrez Gene
v-erb-b2 erythroblastic leukemia viral oncogene

homolog 2, neuro/glioblastoma derived oncogene

homolog (avian)

474
79026
Entrez Gene
AHNAK nucleoprotein (desmoyokin)

475
U77948
GenBank
general transcription factor II, i /// general transcription

factor II, i, pseudogene 1

476
949
Entrez Gene
scavenger receptor class B, member 1

477
1917
Entrez Gene
eukaryotic translation elongation factor 1 alpha 2

478
6205
Entrez Gene
ribosomal protein S11

480
HG1614-
The Institute for
—

HT161
Genomic Research

481
79095
Entrez Gene
chromosome 9 open reading frame 16

483
22924
Entrez Gene
microtubule-associated protein, RP/EB family, member 3

484
26578
Entrez Gene
osteoclast stimulating factor 1

485
1347
Entrez Gene
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)

486
3615
Entrez Gene
IMP (inosine monophosphate) dehydrogenase 2

487
1981
Entrez Gene
eukaryotic translation initiation factor 4 gamma, 1

488
22934
Entrez Gene
ribose 5-phosphate isomerase A (ribose 5-phosphate

epimerase)

490
11311
Entrez Gene
vacuolar protein sorting 45A (yeast)

491
3916
Entrez Gene
lysosomal-associated membrane protein 1

492
23020
Entrez Gene
activating signal cointegrator 1 complex subunit 3-like 1

493
10473
Entrez Gene
high mobility group nucleosomal binding domain 4

494
10075
Entrez Gene
HECT, UBA and WWE domain containing 1

495
6812
Entrez Gene
syntaxin binding protein 1

496
23511
Entrez Gene
nucleoporin 188 kDa

497
HG2238-
The Institute for
—

HT232
Genomic Research

498
283638
Entrez Gene
KIAA0284

499
30968
Entrez Gene
stomatin (EPB72)-like 2

501
10634
Entrez Gene
growth arrest-specific 2 like 1

502
3420
Entrez Gene
isocitrate dehydrogenase 3 (NAD+) beta

503
10424
Entrez Gene
progesterone receptor membrane component 2

504
8531
Entrez Gene
cold shock domain protein A

505
5439
Entrez Gene
polymerase (RNA) II (DNA directed) polypeptide J,

13.3 kDa

506
10929
Entrez Gene
Splicing factor, arginine/serine-rich, 46 kD

507
6227
Entrez Gene
ribosomal protein S21

508
6169
Entrez Gene
ribosomal protein L38

510
6218
Entrez Gene
ribosomal protein S17

511
9540
Entrez Gene
tumor protein p53 inducible protein 3

512
1327
Entrez Gene
cytochrome c oxidase subunit IV isoform 1

514
3030
Entrez Gene
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-

Coenzyme A thiolase/enoyl-Coenzyme A hydratase

(trifunctional protein), alpha subunit

516
3032
Entrez Gene
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-

Coenzyme A thiolase/enoyl-Coenzyme A hydratase

(trifunctional protein), beta subunit

517
5223
Entrez Gene
phosphoglycerate mutase 1 (brain)

518
10638
Entrez Gene
S-phase response (cyclin-related)

520
10572
Entrez Gene
CD27-binding (Siva) protein

522
162427
Entrez Gene
hypothetical protein LOC162427

523
10036
Entrez Gene
chromatin assembly factor 1, subunit A (p150)

524
6202
Entrez Gene
ribosomal protein S8

525
55218
Entrez Gene
chromosome 14 open reading frame 114

527
9724
Entrez Gene
UTP14, U3 small nucleolar ribonucleoprotein, homolog

C (yeast)

528
26003
Entrez Gene
golgi reassembly stacking protein 2, 55 kDa

529
56829
Entrez Gene
zinc finger CCCH-type, antiviral 1

530
4601
Entrez Gene
MAX interactor 1

531
6293
Entrez Gene
vacuolar protein sorting 52 (yeast)

533
10067
Entrez Gene
secretory carrier membrane protein 3

534
5437
Entrez Gene
polymerase (RNA) II (DNA directed) polypeptide H

535
6203
Entrez Gene
ribosomal protein S9

536
55744
Entrez Gene
hypothetical protein FLJ10803

538
5036
Entrez Gene
proliferation-associated 2G4, 38 kDa

539
9249
Entrez Gene
dehydrogenase/reductase (SDR family) member 3

540
1337
Entrez Gene
cytochrome c oxidase subunit VIa polypeptide 1

541
23623
Entrez Gene
RUN and SH3 domain containing 1

542
8890
Entrez Gene
eukaryotic translation initiation factor 2B, subunit 4

delta, 67 kDa

543
203069
Entrez Gene
R3H domain and coiled-coil containing 1

544
7529
Entrez Gene
tyrosine 3-monooxygenase/tryptophan 5-

monooxygenase activation protein, beta polypeptide

545
23294
Entrez Gene
ankyrin repeat and sterile alpha motif domain containing 1

546
29
Entrez Gene
active BCR-related gene

547
1937
Entrez Gene
eukaryotic translation elongation factor 1 gamma

549
147179
Entrez Gene
WIRE protein

553
8480
Entrez Gene
RAE1 RNA export 1 homolog (S. pombe)

558
3163
Entrez Gene
heme oxygenase (decycling) 2

559
22864
Entrez Gene
KIAA1002 protein

560
23307
Entrez Gene
KIAA0674

562
9903
Entrez Gene
kelch-like 21 (Drosophila)

563
5236
Entrez Gene
phosphoglucomutase 1

565
2975
Entrez Gene
general transcription factor IIIC, polypeptide 1, alpha

220 kDa

566
10956
Entrez Gene
amplified in osteosarcoma

567
1201
Entrez Gene
ceroid-lipofuscinosis, neuronal 3, juvenile (Batten,

Spielmeyer-Vogt disease)

569
527
Entrez Gene
ATPase, H+ transporting, lysosomal 16 kDa, V0 subunit c

570
8720
Entrez Gene
membrane-bound transcription factor peptidase, site 1

571
3151
Entrez Gene
high-mobility group nucleosomal binding domain 2

572
286440
Entrez Gene
hypothetical protein LOC286440

573
6136
Entrez Gene
ribosomal protein L12

575
445
Entrez Gene
argininosuccinate synthetase

576
11224
Entrez Gene
ribosomal protein L35

577
11258
Entrez Gene
dynactin 3 (p22)

578
4779
Entrez Gene
nuclear factor (erythroid-derived 2)-like 1

579
149603
Entrez Gene
ring finger protein 187

580
8818
Entrez Gene
dolichyl-phosphate mannosyltransferase polypeptide 2,

regulatory subunit

581
823
Entrez Gene
calpain 1, (mu/l) large subunit

582
5438
Entrez Gene
polymerase (RNA) II (DNA directed) polypeptide I,

14.5 kDa

583
6720
Entrez Gene
sterol regulatory element binding transcription factor 1

584
23633
Entrez Gene
Karyopherin alpha 6 (importin alpha 7)

585
7534
Entrez Gene
tyrosine 3-monooxygenase/tryptophan 5-

monooxygenase activation protein, zeta polypeptide

586
23481
Entrez Gene
pescadillo homolog 1, containing BRCT domain

(zebrafish)

Gene ID
Probe_ID
Comparison
Fold Change
P value

1
36329_at
Day 3 Peri/Day 3 Control
0.131
2.0793E−03

3
32880_at
Day 3 Peri/Day 3 Control
0.211
2.5582E−03

5
38430_at
Day 0 Peri/Day 0 Control
0.219
8.7014E−03

8
32190_at
Day 3 Peri/Day 0 Peri
0.365
8.5757E−03

11
31326_at
Day 7 Peri/Day 7 Control
0.138
7.6909E−03

31326_at
Day 3 Peri/Day 3 Control
0.214
6.7718E−03

31326_at
Day 7 Peri/Day 0 Peri
0.229
1.6500E−05

31326_at
Day 7 Peri/Day 7 Extra
0.288
7.6740E−03

31326_at
Day 3 Peri/Day 0 Peri
0.487
3.0725E−03

13
35730_at
Day 0 Peri/Day 0 Intra
0.252
5.3255E−03

14
37809_at
Day 3 Peri/Day 3 Control
0.180
5.0202E−03

37809_at
Day 7 Peri/Day 7 Extra
0.237
8.7426E−03

37809_at
Day 3 Peri/Day 3 Extra
0.314
9.1991E−03

15
38457_at
Day 0 Peri/Day 0 Control
0.185
5.1425E−04

17
34316_at
Day 3 Peri/Day 3 Control
0.241
3.8100E−05

34316_at
Day 7 Peri/Day 7 Control
0.432
2.3230E−04

34316_at
Day 3 Peri/Day 3 Extra
0.476
1.6785E−04

18
36569_at
Day 3 Peri/Day 0 Peri
0.356
1.8400E−05

36569_at
Day 7 Peri/Day 0 Peri
0.428
5.8746E−04

20
35324_at
Day 3 Peri/Day 0 Peri
0.447
1.3446E−04

35324_at
Day 7 Peri/Day 0 Peri
0.623
4.2479E−03

21
38627_at
Day 0 Peri/Day 0 Intra
0.556
5.7849E−03

22
32392_s_at
Day 3 Peri/Day 3 Extra
0.320
3.1014E−03

24
41473_at
Day 3 Peri/Day 0 Peri
0.521
6.6949E−03

26
36312_at
Day 7 Peri/Day 7 Extra
0.331
4.7432E−04

28
41621_i_at
Day 0 Peri/Day 0 Control
0.350
5.4116E−04

29
41772_at
Day 3 Peri/Day 3 Extra
0.351
3.2109E−03

41771_g_at
Day 3 Peri/Day 3 Control
0.464
2.4030E−03

41772_at
Day 7 Peri/Day 7 Extra
0.614
6.2007E−03

31
34985_at
Day 3 Peri/Day 0 Peri
0.354
4.8214E−04

34985_at
Day 7 Peri/Day 0 Peri
0.381
2.9109E−03

34
37761_at
Day 7 Peri/Day 0 Peri
0.358
3.2292E−04

36
32542_at
Day 3 Peri/Day 0 Peri
0.598
1.0604E−03

32542_at
Day 7 Peri/Day 0 Peri
0.643
1.4304E−03

37
33294_at
Day 0 Peri/Day 0 Control
0.369
2.9368E−04

33294_at
Day 3 Peri/Day 3 Control
0.453
3.7416E−04

38
33860_at
Day 0 Peri/Day 0 Control
0.369
5.2550E−04

33860_at
Day 3 Peri/Day 3 Control
0.374
1.4026E−03

33860_at
Day 7 Peri/Day 7 Control
0.452
4.0374E−03

33860_at
Day 3 Peri/Day 3 Extra
0.549
6.8632E−03

33860_at
Day 7 Peri/Day 7 Extra
0.579
3.6353E−03

39
36113_s_at
Day 7 Peri/Day 7 Control
0.371
6.4628E−03

36113_s_at
Day 3 Peri/Day 3 Control
0.452
4.3070E−03

42
35363_at
Day 0 Peri/Day 0 Control
0.383
2.2472E−03

35363_at
Day 7 Peri/Day 7 Extra
0.577
6.8649E−03

43
35577_at
Day 0 Peri/Day 0 Control
0.385
4.8105E−04

44
38429_at
Day 3 Peri/Day 0 Peri
0.512
8.4627E−03

45
873_at
Day 3 Peri/Day 3 Extra
0.387
6.1920E−03

46
677_s_at
Day 7 Peri/Day 7 Control
0.389
2.8442E−04

677_s_at
Day 7 Peri/Day 7 Extra
0.672
8.0184E−03

49
33007_at
Day 3 Peri/Day 3 Control
0.394
7.4079E−03

50
37185_at
Day 0 Peri/Day 0 Control
0.399
5.5226E−03

51
41158_at
Day 0 Peri/Day 0 Control
0.544
4.8737E−03

41158_at
Day 3 Peri/Day 0 Peri
0.715
7.5707E−03

52
394_at
Day 3 Peri/Day 3 Control
0.404
6.8138E−03

53
1532_g_at
Day 0 Peri/Day 0 Control
0.406
9.9594E−04

1532_g_at
Day 3 Peri/Day 3 Control
0.567
4.1852E−03

1532_g_at
Day 0 Peri/Day 0 Intra
0.660
5.2680E−03

54
40409_at
Day 3 Peri/Day 3 Control
0.445
7.4233E−03

55
1527_s_at
Day 0 Peri/Day 0 Control
0.410
2.0450E−03

1527_s_at
Day 3 Peri/Day 3 Control
0.515
2.5140E−03

56
40282_s_at
Day 7 Peri/Day 0 Peri
0.410
3.2238E−03

57
35669_at
Day 7 Peri/Day 0 Peri
0.543
1.1342E−03

35669_at
Day 3 Peri/Day 0 Peri
0.585
1.2820E−03

58
31610_at
Day 3 Peri/Day 3 Extra
0.421
4.1131E−03

59
35430_at
Day 3 Peri/Day 3 Control
0.427
4.0549E−03

60
33334_at
Day 0 Peri/Day 0 Control
0.427
3.3326E−03

63
34863_s_at
Day 3 Peri/Day 3 Control
0.430
9.0435E−03

64
31431_at
Day 7 Peri/Day 7 Control
0.430
7.9132E−04

65
167_at
Day 3 Peri/Day 3 Control
0.431
3.2376E−04

167_at
Day 7 Peri/Day 7 Extra
0.519
7.0199E−03

66
37441_at
Day 0 Peri/Day 0 Intra
0.432
3.4529E−03

70
38384_at
Day 3 Peri/Day 3 Extra
0.436
8.9104E−03

71
936_s_at
Day 3 Peri/Day 3 Control
0.437
1.3929E−04

936_s_at
Day 7 Peri/Day 7 Control
0.554
6.0851E−03

936_s_at
Day 7 Peri/Day 0 Peri
0.679
6.6192E−03

72
41356_at
Day 3 Peri/Day 3 Extra
0.438
5.3163E−03

74
38798_s_at
Day 0 Peri/Day 0 Control
0.441
6.9369E−03

38798_s_at
Day 3 Peri/Day 3 Control
0.480
6.4090E−03

77
38966_at
Day 7 Peri/Day 7 Control
0.444
3.9851E−03

38966_at
Day 3 Peri/Day 3 Control
0.530
1.4148E−03

38966_at
Day 7 Peri/Day 0 Peri
0.614
2.1060E−03

78
37178_at
Day 3 Peri/Day 3 Control
0.449
3.9314E−03

79
40973_at
Day 0 Peri/Day 0 Control
0.451
2.5568E−03

80
31754_at
Day 3 Peri/Day 3 Extra
0.453
4.6700E−03

81
41258_at
Day 0 Peri/Day 0 Control
0.453
3.7268E−03

82
32242_at
Day 3 Peri/Day 3 Extra
0.454
8.8596E−03

83
41274_at
Day 0 Peri/Day 0 Control
0.454
4.4963E−03

41274_at
Day 3 Peri/Day 3 Control
0.589
7.6530E−03

84
975_at
Day 7 Peri/Day 7 Extra
0.459
4.3469E−03

86
1556_at
Day 0 Peri/Day 0 Control
0.460
1.4047E−03

90
32049_f_at
Day 0 Peri/Day 0 Intra
0.469
3.1906E−03

93
40863_r_at
Day 7 Peri/Day 0 Peri
0.507
3.2271E−04

94
34365_at
Day 3 Peri/Day 3 Control
0.473
5.7231E−03

34365_at
Day 7 Peri/Day 0 Peri
0.638
2.8273E−03

95
1839_at
Day 3 Peri/Day 3 Extra
0.473
1.6274E−03

1839_at
Day 3 Peri/Day 3 Control
0.555
9.8116E−03

97
37628_at
Day 3 Peri/Day 3 Extra
0.475
8.4099E−04

99
39441_at
Day 0 Peri/Day 0 Control
0.482
2.7594E−03

101
37248_at
Day 7 Peri/Day 0 Peri
0.483
2.2125E−04

37248_at
Day 3 Peri/Day 0 Peri
0.522
7.1260E−04

102
32664_at
Day 3 Peri/Day 0 Peri
0.636
5.8524E−04

32664_at
Day 7 Peri/Day 0 Peri
0.691
3.6796E−03

103
39950_at
Day 3 Peri/Day 3 Control
0.483
8.6125E−03

106
35195_at
Day 7 Peri/Day 7 Extra
0.489
1.6326E−03

107
35561_at
Day 7 Peri/Day 0 Peri
0.606
7.2171E−03

108
31888_s_at
Day 3 Peri/Day 3 Extra
0.490
4.0424E−03

109
31903_at
Day 0 Peri/Day 0 Control
0.493
1.3274E−03

110
37534_at
Day 3 Peri/Day 3 Extra
0.493
7.3178E−03

112
38272_at
Day 7 Peri/Day 7 Extra
0.494
1.4839E−03

113
38327_at
Day 3 Peri/Day 3 Extra
0.497
4.4983E−04

38327_at
Day 3 Peri/Day 3 Control
0.512
5.3933E−04

38327_at
Day 3 Peri/Day 0 Peri
0.710
9.2062E−03

115
947_at
Day 0 Peri/Day 0 Control
0.498
7.8436E−04

116
31955_at
Day 7 Peri/Day 7 Control
0.498
8.3003E−03

118
34787_at
Day 3 Peri/Day 3 Control
0.499
2.6275E−03

119
33436_at
Day 3 Peri/Day 3 Extra
0.500
5.3219E−03

120
38739_at
Day 3 Peri/Day 3 Extra
0.501
4.4662E−03

121
32486_at
Day 0 Peri/Day 0 Intra
0.501
6.1425E−03

123
501_g_at
Day 3 Peri/Day 3 Control
0.505
2.0051E−03

129
38847_at
Day 7 Peri/Day 7 Extra
0.510
9.6404E−03

130
1243_at
Day 3 Peri/Day 3 Control
0.511
4.6848E−04

1243_at
Day 0 Peri/Day 0 Control
0.556
6.7443E−03

1243_at
Day 7 Peri/Day 0 Peri
0.749
8.6022E−03

131
40461_at
Day 3 Peri/Day 0 Peri
0.738
3.2244E−03

132
35329_at
Day 3 Peri/Day 3 Control
0.513
1.8894E−03

136
39631_at
Day 3 Peri/Day 3 Extra
0.517
3.1103E−03

39631_at
Day 7 Peri/Day 0 Peri
0.629
5.1967E−04

137
41679_at
Day 7 Peri/Day 0 Peri
0.517
1.2344E−03

41679_at
Day 3 Peri/Day 0 Peri
0.607
8.6951E−03

138
41182_at
Day 7 Peri/Day 0 Peri
0.518
2.7300E−05

41182_at
Day 3 Peri/Day 0 Peri
0.596
1.9071E−04

141
41826_at
Day 0 Peri/Day 0 Control
0.520
5.9389E−03

142
39133_at
Day 7 Peri/Day 7 Control
0.520
1.5729E−03

144
38881_i_at
Day 3 Peri/Day 3 Extra
0.521
1.0549E−04

146
38335_at
Day 0 Peri/Day 0 Intra
0.759
8.2179E−03

148
35773_i_at
Day 7 Peri/Day 7 Control
0.525
1.8840E−03

35773_i_at
Day 7 Peri/Day 0 Peri
0.748
5.4735E−03

35773_i_at
Day 7 Peri/Day 3 Peri
0.791
1.2691E−03

149
33232_at
Day 7 Peri/Day 0 Peri
0.526
3.2907E−04

33232_at
Day 3 Peri/Day 0 Peri
0.596
1.5417E−03

150
36454_at
Day 0 Peri/Day 0 Control
0.526
3.3461E−03

35275_at
Day 3 Peri/Day 3 Extra
0.650
2.8445E−03

151
32743_at
Day 0 Peri/Day 0 Control
0.619
1.5268E−03

32743_at
Day 3 Peri/Day 0 Peri
0.772
6.0079E−03

152
40096_at
Day 3 Peri/Day 3 Control
0.527
6.5302E−03

40096_at
Day 0 Peri/Day 0 Control
0.563
2.0338E−04

154
33029_at
Day 7 Peri/Day 7 Extra
0.530
9.3336E−03

156
653_at
Day 0 Peri/Day 0 Control
0.533
6.1850E−03

157
38347_at
Day 0 Peri/Day 0 Intra
0.533
6.3391E−03

159
37738_g_at
Day 3 Peri/Day 3 Control
0.678
3.6789E−03

160
36497_at
Day 3 Peri/Day 3 Control
0.535
3.4244E−03

36497_at
Day 7 Peri/Day 0 Peri
0.545
2.9700E−05

36497_at
Day 3 Peri/Day 0 Peri
0.577
3.7100E−05

165
33796_at
Day 3 Peri/Day 3 Control
0.537
6.8833E−03

166
34348_at
Day 3 Peri/Day 3 Control
0.537
9.4449E−03

34348_at
Day 0 Peri/Day 0 Control
0.573
7.9326E−03

167
39396_at
Day 3 Peri/Day 3 Control
0.541
7.9687E−03

169
34378_at
Day 7 Peri/Day 7 Extra
0.542
1.2411E−03

170
39074_at
Day 3 Peri/Day 3 Control
0.544
3.5087E−04

173
38113_at
Day 0 Peri/Day 0 Control
0.546
1.8607E−03

175
40615_at
Day 0 Peri/Day 0 Control
0.546
5.1650E−03

176
32112_s_at
Day 3 Peri/Day 3 Extra
0.547
1.9891E−03

178
862_at
Day 3 Peri/Day 3 Extra
0.548
8.5245E−03

178
862_at
Day 7 Peri/Day 7 Extra
0.576
5.9941E−03

179
33128_s_at
Day 7 Peri/Day 0 Peri
0.549
1.9072E−03

33128_s_at
Day 3 Peri/Day 0 Peri
0.605
2.6588E−03

180
34369_at
Day 3 Peri/Day 3 Control
0.549
2.5016E−03

34369_at
Day 3 Peri/Day 3 Extra
0.635
6.4361E−03

182
32259_at
Day 3 Peri/Day 3 Control
0.593
1.0957E−03

183
1070_at
Day 3 Peri/Day 3 Control
0.556
4.5246E−03

185
36786_at
Day 3 Peri/Day 3 Extra
0.556
7.2273E−04

36786_at
Day 7 Peri/Day 7 Control
0.592
1.4203E−03

36786_at
Day 3 Peri/Day 3 Control
0.622
8.0958E−04

36786_at
Day 0 Peri/Day 0 Control
0.668
3.0374E−03

36786_at
Day 7 Peri/Day 0 Peri
0.783
1.0376E−03

186
32618_at
Day 3 Peri/Day 3 Control
0.557
3.0605E−04

32618_at
Day 3 Peri/Day 3 Extra
0.620
3.2950E−04

32618_at
Day 0 Peri/Day 0 Control
0.677
7.9770E−03

32618_at
Day 3 Peri/Day 3 Intra
0.702
5.1159E−03

187
31936_s_at
Day 3 Peri/Day 3 Control
0.558
3.7112E−03

188
35435_s_at
Day 3 Peri/Day 3 Extra
0.558
7.5277E−03

354345_s_at
Day 7 Peri/Day 7 Extra
0.692
5.5220E−03

190
41322_s_at
Day 3 Peri/Day 3 Extra
0.559
1.2634E−03

191
37597_s_at
Day 3 Peri/Day 3 Control
0.560
4.7635E−03

37597_s_at
Day 3 Peri/Day 3 Extra
0.566
9.6420E−04

192
33988_at
Day 3 Peri/Day 3 Control
0.560
1.0937E−03

33988_at
Day 3 Peri/Day 3 Extra
0.582
8.2347E−04

193
39377_at
Day 3 Peri/Day 3 Extra
0.561
3.7750E−03

39377_at
Day 3 Peri/Day 3 Control
0.571
9.8955E−03

39377_at
Day 3 Peri/Day 3 Intra
0.634
9.8004E−03

194
160044_g_at
Day 3 Peri/Day 3 Control
0.562
5.6984E−03

195
31691_g_at
Day 3 Peri/Day 3 Control
0.563
6.9886E−03

197
32161_at
Day 0 Peri/Day 0 Intra
0.565
2.6625E−03

198
39856_at
Day 0 Peri/Day 0 Control
0.568
7.8476E−03

199
421_at
Day 0 Peri/Day 0 Control
0.569
3.6369E−03

201
33399_at
Day 3 Peri/Day 3 Extra
0.571
4.6866E−03

202
38824_at
Day 3 Peri/Day 3 Control
0.571
7.2789E−03

38824_at
Day 3 Peri/Day 3 Extra
0.592
5.7073E−03

203
39103_s_at
Day 3 Peri/Day 3 Control
0.571
2.1724E−04

39103_s_at
Day 3 Peri/Day 3 Extra
0.601
5.7200E−03

204
34845_at
Day 3 Peri/Day 3 Extra
0.572
1.2889E−03

205
40437_at
Day 3 Peri/Day 3 Control
0.572
3.2143E−03

206
32523_at
Day 3 Peri/Day 3 Control
0.573
4.0809E−03

207
374_f_at
Day 7 Peri/Day 7 Control
0.573
7.7105E−03

208
31492_at
Day 3 Peri/Day 3 Extra
0.574
7.4544E−04

209
32747_at
Day 3 Peri/Day 3 Extra
0.574
5.1549E−04

32747_at
Day 7 Peri/Day 0 Peri
0.741
2.4111E−03

210
41234_at
Day 7 Peri/Day 7 Extra
0.577
3.8743E−03

212
36553_at
Day 3 Peri/Day 0 Peri
0.710
1.0994E−04

213
38312_at
Day 3 Peri/Day 0 Peri
0.719
4.2489E−04

214
41029_at
Day 3 Peri/Day 3 Extra
0.580
1.0146E−03

215
34760_at
Day 0 Peri/Day 0 Intra
0.580
5.4949E−04

216
34893_at
Day 7 Peri/Day 7 Control
0.581
9.2931E−03

34893_at
Day 7 Peri/Day 7 Extra
0.600
1.3243E−03

217
35371_at
Day 3 Peri/Day 3 Control
0.582
1.9359E−03

35371_at
Day 3 Peri/Day 3 Extra
0.618
2.4693E−03

218
37708_r_at
Day 0 Peri/Day 0 Intra
0.600
6.4350E−03

220
36992_at
Day 3 Peri/Day 3 Extra
0.583
3.0827E−03

36992_at
Day 3 Peri/Day 3 Intra
0.673
4.8045E−03

222
40138_at
Day 7 Peri/Day 7 Control
0.584
6.5665E−03

223
1597_at
Day 3 Peri/Day 0 Peri
0.689
5.8701E−03

224
41257_at
Day 0 Peri/Day 0 Intra
0.700
3.4819E−03

228
37002_at
Day 7 Peri/Day 7 Control
0.588
8.3451E−04

229
36284_at
Day 7 Peri/Day 7 Extra
0.589
9.2936E−03

230
35367_at
Day 7 Peri/Day 0 Peri
0.683
4.0159E−04

35367_at
Day 3 Peri/Day 0 Peri
0.763
8.3297E−03

231
1373_at
Day 3 Peri/Day 0 Peri
0.738
3.1310E−04

232
35760_at
Day 3 Peri/Day 3 Extra
0.590
1.5912E−03

35760_at
Day 0 Peri/Day 0 Control
0.738
8.9277E−03

233
40303_at
Day 3 Peri/Day 3 Control
0.591
7.9662E−03

234
40764_at
Day 3 Peri/Day 3 Extra
0.591
2.0500E−03

235
32586_at
Day 0 Peri/Day 0 Control
0.591
3.7384E−03

32586_at
Day 3 Peri/Day 3 Control
0.685
8.4169E−04

32586_at
Day 3 Peri/Day 3 Extra
0.782
5.1596E−03

237
37668_at
Day 3 Peri/Day 3 Extra
0.591
6.3705E−03

238
40946_at
Day 3 Peri/Day 3 Extra
0.593
3.2988E−03

239
41403_at
Day 3 Peri/Day 3 Extra
0.593
2.1695E−03

41403_at
Day 7 Peri/Day 7 Extra
0.674
9.8788E−04

240
34990_at
Day 3 Peri/Day 0 Peri
0.593
3.4533E−04

34990_at
Day 7 Peri/Day 0 Peri
0.711
9.8766E−03

241
32715_at
Day 3 Peri/Day 3 Extra
0.593
2.2624E−03

32715_at
Day 0 Peri/Day 0 Control
0.628
1.3473E−03

243
2051_at
Day 7 Peri/Day 7 Control
0.594
5.4697E−03

245
34350_at
Day 7 Peri/Day 7 Extra
0.595
8.1420E−03

246
33916_at
Day 0 Peri/Day 0 Control
0.595
3.7132E−03

33916_at
Day 3 Peri/Day 3 Control
0.647
6.0432E−03

248
32766_at
Day 3 Peri/Day 3 Extra
0.597
8.7735E−04

249
37229_at
Day 7 Peri/Day 7 Extra
0.619
5.1546E−03

250
40822_at
Day 0 Peri/Day 0 Control
0.597
3.4027E−03

40823_s_at
Day 3 Peri/Day 3 Extra
0.633
7.3198E−03

40822_at
Day 0 Peri/Day 0 Intra
0.746
7.0070E−03

252
1378_g_at
Day 3 Peri/Day 3 Extra
0.598
6.5881E−03

1378_g_at
Day 0 Peri/Day 0 Control
0.646
7.6400E−03

254
40440_at
Day 0 Peri/Day 0 Control
0.599
7.7405E−03

40440_at
Day 3 Peri/Day 3 Intra
0.727
9.5681E−03

255
41569_at
Day 7 Peri/Day 7 Extra
0.599
4.9293E−03

257
39025_at
Day 7 Peri/Day 7 Control
0.716
2.2149E−03

39025_at
Day 7 Peri/Day 0 Peri
0.798
1.0424E−03

258
1719_at
Day 3 Peri/Day 3 Extra
0.603
6.7926E−03

259
218_at
Day 3 Peri/Day 3 Control
0.606
4.9835E−04

260
33675_at
Day 3 Peri/Day 0 Peri
0.606
4.5158E−03

262
34310_at
Day 3 Peri/Day 3 Control
0.607
7.6231E−03

34310_at
Day 3 Peri/Day 3 Intra
0.619
3.4883E−03

263
36111_s_at
Day 7 Peri/Day 7 Extra
0.607
1.0792E−03

265
41804_at
Day 3 Peri/Day 3 Control
0.608
1.1934E−04

266
39883_at
Day 7 Peri/Day 7 Extra
0.609
2.6811E−03

267
37828_at
Day 0 Peri/Day 0 Intra
0.626
4.8045E−03

268
37992_s_at
Day 7 Peri/Day 7 Control
0.611
6.2111E−03

269
35736_at
Day 0 Peri/Day 0 Control
0.611
4.7952E−03

271
32395_r_at
Day 3 Peri/Day 3 Extra
0.611
2.2508E−03

273
34950_at
Day 3 Peri/Day 0 Peri
0.613
2.6182E−04

275
40087_at
Day 3 Peri/Day 3 Control
0.614
3.7491E−03

276
41837_at
Day 3 Peri/Day 0 Peri
0.614
6.2326E−04

276
41837_at
Day 7 Peri/Day 0 Peri
0.660
1.7553E−03

277
33337_at
Day 3 Peri/Day 3 Control
0.614
8.5255E−03

33337_at
Day 7 Peri/Day 7 Control
0.626
3.0395E−03

33337_at
Day 7 Peri/Day 0 Peri
0.690
1.2271E−03

278
38451_at
Day 7 Peri/Day 7 Control
0.614
8.2100E−05

279
40497_at
Day 0 Peri/Day 0 Control
0.614
9.7424E−03

40497_at
Day 3 Peri/Day 3 Control
0.655
1.1667E−04

280
34841_at
Day 3 Peri/Day 3 Extra
0.615
9.0352E−03

34841_at
Day 3 Peri/Day 0 Peri
0.776
9.4126E−03

281
39823_at
Day 3 Peri/Day 3 Control
0.616
2.9015E−03

282
34414_at
Day 0 Peri/Day 0 Intra
0.644
5.3735E−03

285
1898_at
Day 7 Peri/Day 0 Peri
0.617
3.0138E−03

286
32576_at
Day 3 Peri/Day 3 Extra
0.617
4.1860E−03

287
40774_at
Day 3 Peri/Day 3 Extra
0.617
6.5552E−3

290
35966_at
Day 0 Peri/Day 0 Intra
0.663
6.8919E−03

291
34352_at
Day 7 Peri/Day 7 Control
0.620
2.4354E−03

34352_at
Day 3 Peri/Day 3 Intra
0.704
1.5982E−03

292
1356_at
Day 0 Peri/Day 0 Control
0.621
1.4788E−03

293
32805_at
Day 3 Peri/Day 3 Extra
0.621
6.7226E−03

294
40086_at
Day 3 Peri/Day 3 Control
0.623
5.5939E−03

295
36463_at
Day 3 Peri/Day 3 Extra
0.624
7.6918E−03

296
41329_at
Day 3 Peri/Day 3 Control
0.624
2.9063E−03

298
33351_at
Day 0 Peri/Day 0 Intra
0.624
5.2711E−04

299
38131_at
Day 3 Peri/Day 3 Extra
0.626
9.0721E−03

300
41498_at
Day 3 Peri/Day 3 Control
0.626
9.2124E−04

41498_at
Day 3 Peri/Day 0 Peri
0.777
3.9252E−03

301
2093_s_at
Day 3 Peri/Day 3 Control
0.627
1.0646E−03

38733_at
Day 0 Peri/Day 0 Control
0.644
9.6568E−03

303
38911_at
Day 3 Peri/Day 3 Extra
0.627
2.3405E−03

304
35702_at
Day 7 Peri/Day 0 Peri
0.628
6.5442E−03

305
32592_at
Day 0 Peri/Day 0 Control
0.628
8.9436E−04

306
2089_s_at
Day 0 Peri/Day 0 Control
0.629
5.0250E−03

32787_at
Day 7 Peri/Day 0 Peri
0.677
7.5081E−03

307
40196_at
Day 3 Peri/Day 3 Control
0.630
3.3471E−03

40196_at
Day 7 Peri/Day 0 Peri
0.735
2.0122E−03

40196_at
Day 3 Peri/Day 0 Peri
0.770
5.2302E−03

308
34270_at
Day 3 Peri/Day 3 Control
0.631
1.9266E−03

309
37161_at
Day 3 Peri/Day 3 Extra
0.631
4.5494E−03

37161_at
Day 3 Peri/Day 3 Control
0.640
6.9170E−03

311
37005_at
Day 7 Peri/Day 0 Peri
0.642
1.7449E−03

37005_at
Day 3 Peri/Day 0 Peri
0.695
2.4042E−03

314
39916_r_at
Day 7 Peri/Day 7 Control
0.633
1.4158E−03

39916_r_at
Day 3 Peri/Day 3 Control
0.675
7.7101E−03

316
40882_at
Day 7 Peri/Day 7 Intra
0.635
9.8901E−03

317
36945_at
Day 3 Peri/Day 3 Control
0.635
9.2309E−04

318
37321_at
Day 3 Peri/Day 3 Control
0.635
7.5603E−03

321
31952_at
Day 3 Peri/Day 3 Extra
0.637
8.7667E−03

322
36592_at
Day 3 Peri/Day 3 Extra
0.637
3.4444E−03

323
37395_at
Day 7 Peri/Day 7 Control
0.638
2.2448E−03

37395_at
Day 3 Peri/Day 3 Control
0.722
8.6817E−04

37395_at
Day 3 Peri/Day 3 Extra
0.810
7.4746E−03

37395_at
Day 7 Peri/Day 0 Peri
0.840
4.0330E−03

324
40872_at
Day 3 Peri/Day 3 Extra
0.638
1.3105E−03

325
32756_at
Day 3 Peri/Day 3 Extra
0.638
8.7097E−03

326
37982_at
Day 7 Peri/Day 7 Control
0.639
2.3722E−03

327
35748_at
Day 3 Peri/Day 3 Extra
0.639
7.6265E−04

328
31546_at
Day 7 Peri/Day 7 Control
0.639
6.9963E−03

31546_at
Day 3 Peri/Day 3 Extra
0.691
6.7124E−03

31546_at
Day 7 Peri/Day 0 Peri
0.760
9.8180E−03

330
34791_at
Day 3 Peri/Day 3 Extra
0.640
3.7040E−03

331
38242_at
Day 3 Peri/Day 3 Extra
0.640
7.2677E−04

332
34798_at
Day 3 Peri/Day 3 Control
0.642
4.4022E−03

333
38903_at
Day 7 Peri/Day 0 Peri
0.643
1.7967E−03

335
32045_at
Day 0 Peri/Day 0 Control
0.644
6.8658E−03

336
32173_at
Day 7 Peri/Day 7 Extra
0.645
6.3967E−03

32173_at
Day 3 Peri/Day 3 Control
0.659
6.9500E−03

338
35907_at
Day 3 Peri/Day 3 Extra
0.646
8.5538E−03

339
1278_at
Day 3 Peri/Day 0 Peri
0.647
6.0118E−03

340
32440_at
Day 3 Peri/Day 3 Extra
0.647
6.1617E−03

341
40587_s_at
Day 3 Peri/Day 3 Intra
0.697
4.8656E−04

40587_s_at
Day 3 Peri/Day 3 Extra
0.718
6.3530E−03

342
39219_at
Day 7 Peri/Day 7 Extra
0.647
8.7653E−03

343
32139_at
Day 0 Peri/Day 0 Control
0.648
5.7560E−03

344
35298_at
Day 3 Peri/Day 3 Extra
0.649
2.0180E−03

345
35983_at
Day 3 Peri/Day 3 Extra
0.651
3.7380E−03

346
31527_at
Day 3 Peri/Day 3 Extra
0.651
6.9801E−03

347
41551_at
Day 7 Peri/Day 7 Extra
0.651
8.1132E−03

348
31921_at
Day 3 Peri/Day 3 Control
0.652
2.1176E−03

349
33117_r_at
Day 3 Peri/Day 3 Extra
0.652
2.4740E−03

350
36942_at
Day 0 Peri/Day 0 Control
0.653
5.6656E−03

351
31519_f_at
Day 0 Peri/Day 0 Intra
0.653
9.2891E−03

353
291_s_at
Day 0 Peri/Day 0 Control
0.654
9.5683E−03

291_s_at
Day 3 Peri/Day 3 Extra
0.655
8.7414E−03

354
31680_at
Day 7 Peri/Day 7 Extra
0.654
8.0454E−03

355
38369_at
Day 7 Peri/Day 7 Extra
0.654
5.5186E−03

357
41223_at
Day 3 Peri/Day 3 Extra
0.656
7.0969E−03

358
34401_at
Day 3 Peri/Day 3 Extra
0.656
5.8159E−03

359
36880_at
Day 7 Peri/Day 7 Control
0.657
7.2935E−03

362
956_at
Day 7 Peri/Day 7 Extra
0.658
8.0238E−03

364
38702_at
Day 3 Peri/Day 3 Extra
0.660
3.6355E−03

366
32528_at
Day 7 Peri/Day 7 Intra
0.661
7.3475E−03

367
36846_s_at
Day 7 Peri/Day 7 Control
0.662
8.8105E−04

368
35351_at
Day 3 Peri/Day 3 Extra
0.662
1.3875E−03

369
41037_at
Day 7 Peri/Day 7 Extra
0.662
6.4186E−04

370
1009_at
Day 3 Peri/Day 3 Extra
0.662
6.3134E−03

1009_at
Day 3 Peri/Day 3 Intra
0.704
8.1604E−03

372
41040_at
Day 7 Peri/Day 7 Extra
0.663
2.3436E−03

373
39418_at
Day 7 Peri/Day 7 Extra
0.664
2.4392E−03

39418_at
Day 3 Peri/Day 3 Extra
0.730
4.3297E−03

374
31722_at
Day 3 Peri/Day 3 Extra
0.665
8.4932E−03

31722_at
Day 7 Peri/Day 0 Peri
0.792
9.5624E−03

375
31957_r_at
Day 7 Peri/Day 0 Peri
0.666
3.7416E−03

378
38810_at
Day 3 Peri/Day 3 Control
0.667
1.7702E−04

38810_at
Day 7 Peri/Day 0 Peri
0.778
7.8739E−03

38810_at
Day 3 Peri/Day 0 Peri
0.784
9.3572E−04

379
34693_at
Day 7 Peri/Day 0 Peri
0.668
5.8340E−04

380
1151_at
Day 3 Peri/Day 3 Control
0.669
1.5550E−03

381
39767_at
Day 3 Peri/Day 3 Extra
0.669
4.6792E−03

383
39250_at
Day 3 Peri/Day 0 Peri
0.670
5.1134E−03

384
36214_at
Day 7 Peri/Day 0 Peri
0.670
7.5246E−03

385
36169_at
Day 3 Peri/Day 3 Control
0.671
5.9310E−04

36169_at
Day 3 Peri/Day 3 Extra
0.706
1.3204E−03

36169_at
Day 7 Peri/Day 7 Control
0.710
9.3036E−03

36169_at
Day 3 Peri/Day 3 Intra
0.754
3.5482E−03

386
35266_at
Day 3 Peri/Day 0 Peri
0.815
4.1112E−03

388
32536_at
Day 3 Peri/Day 3 Extra
0.672
3.7237E−03

389
35327_at
Day 3 Peri/Day 3 Control
0.672
5.0660E−03

395
35841_at
Day 7 Peri/Day 7 Control
0.676
2.4659E−03

396
37305_at
Day 7 Peri/Day 7 Extra
0.677
5.6094E−03

37305_at
Day 3 Peri/Day 3 Extra
0.701
9.0063E−03

398
33396_at
Day 3 Peri/Day 3 Extra
0.679
6.0265E−03

33396_at
Day 7 Peri/Day 7 Extra
0.695
5.1049E−03

401
31708_at
Day 3 Peri/Day 3 Extra
0.682
4.7648E−03

402
38076_at
Day 3 Peri/Day 3 Extra
0.682
3.2512E−04

403
37936_at
Day 3 Peri/Day 3 Extra
0.682
1.2100E−03

37936_at
Day 3 Peri/Day 3 Intra
0.809
4.3656E−03

404
40778_at
Day 3 Peri/Day 3 Control
0.683
9.5528E−03

40778_at
Day 3 Peri/Day 3 Extra
0.687
5.4834E−03

40778_at
Day 0 Peri/Day 0 Control
0.700
6.7401E−03

40778_at
Day 7 Peri/Day 0 Peri
0.785
3.6406E−03

405
37295_at
Day 7 Peri/Day 7 Extra
0.683
5.1041E−03

406
36135_at
Day 3 Peri/Day 3 Extra
0.683
7.3375E−03

407
38635_at
Day 7 Peri/Day 7 Control
0.684
3.2000E−03

408
1490_at
Day 3 Peri/Day 0 Peri
0.684
2.9494E−04

410
31869_at
Day 0 Peri/Day 0 Intra
0.684
5.9906E−03

411
1160_at
Day 3 Peri/Day 3 Control
0.685
9.9616E−03

412
35309_at
Day 3 Peri/Day 3 Extra
0.685
2.8284E−03

413
32433_at
Day 0 Peri/Day 0 Intra
0.686
4.8021E−03

415
32745_at
Day 3 Peri/Day 3 Control
0.688
7.4413E−03

416
33164_at
Day 7 Peri/Day 0 Peri
0.688
8.0384E−03

417
38271_at
Day 0 Peri/Day 0 Intra
0.776
6.2327E−03

418
32575_at
Day 3 Peri/Day 3 Control
0.689
7.9600E−05

32575_at
Day 3 Peri/Day 3 Intra
0.820
9.3028E−03

419
1470_at
Day 3 Peri/Day 3 Intra
0.689
5.7659E−03

420
35751_at
Day 3 Peri/Day 3 Extra
0.689
9.9046E−03

421
40745_at
Day 3 Peri/Day 3 Extra
0.689
1.6623E−03

423
37739_at
Day 3 Peri/Day 3 Extra
0.690
4.8988E−03

424
33850_at
Day 3 Peri/Day 0 Peri
0.690
9.2919E−04

33850_at
Day 7 Peri/Day 0 Peri
0.747
8.7450E−03

425
41408_at
Day 3 Peri/Day 3 Extra
0.691
6.4202E−03

426
34315_at
Day 3 Peri/Day 3 Extra
0.692
3.6562E−04

429
39503_s_at
Day 7 Peri/Day 0 Peri
0.693
9.8616E−03

431
286_at
Day 3 Peri/Day 3 Control
0.693
7.8013E−03

432
32437_at
Day 3 Peri/Day 3 Extra
0.693
1.4564E−03

32437_at
Day 7 Peri/Day 0 Peri
0.740
3.6964E−03

32437_at
Day 3 Peri/Day 0 Peri
0.808
6.6422E−03

433
36894_at
Day 3 Peri/Day 3 Control
0.693
8.8784E−03

36894_at
Day 3 Peri/Day 0 Peri
0.742
1.6692E−03

36894_at
Day 7 Peri/Day 0 Peri
0.742
3.4050E−03

434
41746_at
Day 3 Peri/Day 3 Control
0.693
5.4886E−03

434
41746_at
Day 3 Peri/Day 0 Peri
0.830
6.1703E−03

436
36529_at
Day 3 Peri/Day 0 Peri
0.694
6.8032E−03

437
2025_s_at
Day 3 Peri/Day 3 Control
0.695
4.9002E−03

2025_s_at
Day 3 Peri/Day 3 Extra
0.746
9.3963E−03

438
39698_at
Day 7 Peri/Day 0 Peri
0.695
8.7289E−03

439
33997_at
Day 0 Peri/Day 0 Intra
0.731
4.0375E−03

440
36167_at
Day 7 Peri/Day 7 Control
0.696
9.2513E−03

441
38485_at
Day 3 Peri/Day 3 Extra
0.696
2.0589E−03

442
34835_at
Day 3 Peri/Day 3 Extra
0.696
1.6857E−03

34835_at
Day 3 Peri/Day 3 Intra
0.790
4.8084E−03

445
33255_at
Day 3 Peri/Day 3 Control
0.696
9.0975E−03

446
529_at
Day 7 Peri/Day 7 Extra
0.697
3.7478E−03

449
34810_at
Day 7 Peri/Day 7 Control
0.700
1.2592E−03

34810_at
Day 7 Peri/Day 0 Peri
0.810
4.2261E−03

452
37029_at
Day 3 Peri/Day 3 Intra
0.701
5.7342E−03

453
38054_at
Day 3 Peri/Day 3 Control
0.704
9.1709E−03

455
37294_at
Day 3 Peri/Day 3 Extra
0.704
5.5679E−03

457
982_at
Day 7 Peri/Day 3 Peri
0.706
4.9235E−04

458
33883_at
Day 7 Peri/Day 0 Peri
0.706
2.0000E−05

33883_at
Day 3 Peri/Day 0 Peri
0.718
6.1275E−04

459
37704_at
Day 3 Peri/Day 3 Control
0.707
1.4726E−03

37704_at
Day 3 Peri/Day 3 Extra
0.720
1.7216E−03

460
36124_at
Day 7 Peri/Day 0 Peri
0.707
7.1338E−04

461
41483_s_at
Day 7 Peri/Day 0 Peri
0.707
9.7391E−03

462
39814_s_at
Day 3 Peri/Day 3 Extra
0.708
6.9810E−03

39814_s_at
Day 3 Peri/Day 3 Intra
0.740
6.8403E−03

463
36862_at
Day 3 Peri/Day 3 Control
0.709
6.5040E−03

464
41503_at
Day 3 Peri/Day 0 Peri
0.709
9.7700E−05

41503_at
Day 7 Peri/Day 0 Peri
0.830
5.9812E−03

465
34679_at
Day 3 Peri/Day 3 Extra
0.709
4.4827E−03

466
1030_s_at
Day 7 Peri/Day 7 Extra
0.711
1.5853E−03

467
39921_at
Day 3 Peri/Day 3 Extra
0.711
8.1965E−03

469
37311_at
Day 3 Peri/Day 3 Extra
0.713
2.9353E−04

470
38016_at
Day 0 Peri/Day 0 Intra
0.714
4.2703E−03

471
36187_at
Day 3 Peri/Day 3 Extra
0.715
1.3879E−03

36187_at
Day 3 Peri/Day 3 Control
0.730
5.3879E−03

472
33218_at
Day 3 Peri/Day 0 Peri
0.718
4.9044E−04

33218_at
Day 7 Peri/Day 0 Peri
0.740
6.2999E−04

474
37027_at
Day 7 Peri/Day 0 Peri
0.748
8.8700E−05

37027_at
Day 3 Peri/Day 0 Peri
0.780
3.1374E−04

475
35450_s_at
Day 0 Peri/Day 0 Control
0.718
8.5556E−03

476
41200_at
Day 7 Peri/Day 0 Peri
0.720
1.3768E−03

41200_at
Day 3 Peri/Day 0 Peri
0.721
1.6250E−03

477
35174_i_at
Day 7 Peri/Day 0 Peri
0.720
6.7372E−04

478
32330_at
Day 7 Peri/Day 0 Peri
0.721
3.3215E−03

480
954_s_at
Day 7 Peri/Day 7 Control
0.722
8.4646E−03

954_s_at
Day 7 Peri/Day 7 Intra
0.747
1.0730E−03

481
41047_at
Day 3 Peri/Day 0 Peri
0.725
5.9374E−03

483
40825_at
Day 7 Peri/Day 0 Peri
0.725
1.1882E−03

40825_at
Day 3 Peri/Day 0 Peri
0.765
2.4008E−03

484
467_at
Day 7 Peri/Day 7 Extra
0.725
7.2710E−03

485
41760_at
Day 3 Peri/Day 3 Extra
0.726
1.4279E−03

486
36624_at
Day 3 Peri/Day 3 Extra
0.726
5.8955E−03

36624_at
Day 7 Peri/Day 0 Peri
0.740
8.1540E−04

487
32844_at
Day 7 Peri/Day 0 Peri
0.727
9.4700E−03

488
38036_at
Day 0 Peri/Day 0 Intra
0.729
4.9732E−03

490
35779_at
Day 0 Peri/Day 0 Intra
0.731
7.1397E−03

491
39758_f_at
Day 3 Peri/Day 3 Extra
0.732
1.6743E−03

492
41224_at
Day 3 Peri/Day 3 Extra
0.732
7.2017E−03

493
35738_at
Day 3 Peri/Day 3 Control
0.732
4.8156E−03

494
34372_at
Day 3 Peri/Day 0 Peri
0.802
9.1907E−03

495
33942_s_at
Day 3 Peri/Day 3 Extra
0.734
2.7323E−03

496
32644_at
Day 3 Peri/Day 3 Extra
0.735
1.7224E−03

497
329_s_at
Day 3 Peri/Day 0 Peri
0.736
9.9413E−03

498
38592_s_at
Day 3 Peri/Day 3 Extra
0.736
1.6693E−03

38592_s_at
Day 3 Peri/Day 3 Control
0.788
5.7373E−03

499
34380_at
Day 3 Peri/Day 3 Extra
0.736
6.0626E−03

501
31874_at
Day 7 Peri/Day 0 Peri
0.737
7.5700E−05

31874_at
Day 3 Peri/Day 0 Peri
0.791
1.9327E−03

502
40111_g_at
Day 3 Peri/Day 3 Extra
0.737
9.0628E−03

503
38821_at
Day 7 Peri/Day 0 Peri
0.738
3.9496E−03

38821_at
Day 3 Peri/Day 0 Peri
0.746
7.1002E−03

504
39839_at
Day 7 Peri/Day 0 Peri
0.738
8.5534E−03

505
1486_at
Day 7 Peri/Day 0 Peri
0.740
2.7928E−03

1486_at
Day 7 Peri/Day 3 Peri
0.772
1.7983E−03

506
32038_s_at
Day 3 Peri/Day 3 Control
0.740
6.3052E−03

507
32744_at
Day 7 Peri/Day 0 Peri
0.740
7.2902E−03

508
34085_at
Day 7 Peri/Day 0 Peri
0.743
6.3557E−03

510
34592_at
Day 7 Peri/Day 0 Peri
0.745
2.8146E−03

511
36079_at
Day 3 Peri/Day 3 Intra
0.746
5.1335E−03

512
39027_at
Day 3 Peri/Day 3 Extra
0.746
6.3689E−03

514
36952_at
Day 3 Peri/Day 3 Extra
0.750
6.1291E−03

36952_at
Day 0 Peri/Day 0 Control
0.835
2.4582E−03

516
39741_at
Day 3 Peri/Day 3 Extra
0.752
2.0159E−03

517
41221_at
Day 3 Peri/Day 3 Extra
0.752
1.6814E−03

518
1685_at
Day 3 Peri/Day 0 Peri
0.754
1.2093E−03

520
39020_at
Day 3 Peri/Day 3 Control
0.754
9.5129E−03

522
38423_at
Day 0 Peri/Day 0 Control
0.755
7.1257E−03

38423_at
Day 3 Peri/Day 0 Peri
0.845
2.2722E−03

38423_at
Day 7 Peri/Day 0 Peri
0.848
1.7317E−03

523
32589_at
Day 7 Peri/Day 7 Extra
0.756
2.8970E−03

524
31583_at
Day 7 Peri/Day 0 Peri
0.756
8.6210E−03

525
35283_at
Day 0 Peri/Day 0 Control
0.759
7.7904E−04

527
39405_at
Day 0 Peri/Day 0 Intra
0.760
3.9078E−03

528
35805_at
Day 3 Peri/Day 0 Peri
0.761
2.3291E−04

35805_at
Day 7 Peri/Day 0 Peri
0.770
2.6315E−03

529
35682_at
Day 3 Peri/Day 3 Control
0.761
2.0789E−04

530
654_at
Day 7 Peri/Day 0 Peri
0.783
5.2959E−03

39072_at
Day 3 Peri/Day 0 Peri
0.839
6.8595E−03

531
32658_at
Day 0 Peri/Day 0 Control
0.762
7.4217E−03

32658_at
Day 7 Peri/Day 0 Peri
0.858
6.8088E−03

533
32799_at
Day 7 Peri/Day 0 Peri
0.763
8.9346E−03

534
35631_at
Day 3 Peri/Day 3 Extra
0.764
7.2269E−03

35631_at
Day 3 Peri/Day 3 Intra
0.772
5.4217E−03

535
31511_at
Day 7 Peri/Day 0 Peri
0.764
7.8708E−03

536
37610_at
Day 3 Peri/Day 3 Extra
0.764
2.5200E−03

538
41600_at
Day 7 Peri/Day 0 Peri
0.765
6.9426E−03

539
40782_at
Day 3 Peri/Day 0 Peri
0.765
6.4510E−03

540
41206_r_at
Day 7 Peri/Day 0 Peri
0.766
1.7769E−03

541
34264_at
Day 3 Peri/Day 3 Intra
0.768
9.1280E−03

542
32659_at
Day 3 Peri/Day 3 Control
0.768
8.3725E−03

543
35156_at
Day 7 Peri/Day 0 Peri
0.769
8.4083E−03

544
32324_at
Day 3 Peri/Day 3 Extra
0.769
5.4500E−03

545
40971_at
Day 3 Peri/Day 0 Peri
0.796
3.4853E−03

546
39058_at
Day 3 Peri/Day 3 Control
0.771
7.8298E−03

39058_at
Day 3 Peri/Day 3 Extra
0.796
8.8684E−03

547
1676_s_at
Day 7 Peri/Day 0 Peri
0.771
8.5875E−03

549
40787_at
Day 3 Peri/Day 0 Peri
0.772
8.6910E−04

553
32757_at
Day 3 Peri/Day 3 Extra
0.778
1.2850E−03

32758_g_at
Day 7 Peri/Day 7 Intra
0.786
2.2519E−03

558
37916_at
Day 7 Peri/Day 3 Peri
0.781
9.4119E−03

559
41366_at
Day 3 Peri/Day 0 Peri
0.781
8.7647E−03

560
31826_at
Day 0 Peri/Day 0 Control
0.783
2.4933E−03

562
37230_at
Day 3 Peri/Day 0 Peri
0.786
5.6275E−03

37230_at
Day 7 Peri/Day 0 Peri
0.812
4.4808E−03

563
32210_at
Day 3 Peri/Day 0 Peri
0.789
7.7233E−03

565
35671_at
Day 7 Peri/Day 0 Peri
0.791
3.1660E−03

566
36996_at
Day 7 Peri/Day 0 Peri
0.791
9.0785E−03

36996_at
Day 3 Peri/Day 0 Peri
0.818
6.2854E−03

567
497_at
Day 3 Peri/Day 3 Control
0.792
5.8473E−03

569
36994_at
Day 7 Peri/Day 0 Peri
0.794
8.6116E−03

570
36964_at
Day 3 Peri/Day 0 Peri
0.795
9.8019E−03

571
41231_f_at
Day 3 Peri/Day 3 Extra
0.796
7.6383E−04

41231_f_at
Day 3 Peri/Day 3 Intra
0.827
4.3201E−03

572
41655_at
Day 3 Peri/Day 0 Peri
0.796
8.4134E−03

573
33668_at
Day 7 Peri/Day 0 Peri
0.797
2.3409E−03

575
40541_at
Day 7 Peri/Day 3 Peri
0.799
7.5623E−03

576
41765_at
Day 7 Peri/Day 0 Peri
0.800
6.9298E−03

577
40410_at
Day 3 Peri/Day 3 Control
0.808
6.4549E−03

578
38439_at
Day 7 Peri/Day 0 Peri
0.811
5.5209E−03

579
39722_at
Day 3 Peri/Day 0 Peri
0.812
7.5346E−03

580
38726_at
Day 7 Peri/Day 3 Peri
0.814
3.7920E−03

581
33908_at
Day 7 Peri/Day 3 Peri
0.815
9.2186E−03

582
34828_at
Day 0 Peri/Day 0 Control
0.816
8.6878E−03

583
32135_at
Day 3 Peri/Day 0 Peri
0.819
6.4366E−03

584
40275_at
Day 3 Peri/Day 0 Peri
0.824
1.6981E−03

40275_at
Day 7 Peri/Day 0 Peri
0.847
5.5244E−03

585
1235_at
Day 3 Peri/Day 3 Extra
0.824
9.9973E−03

1235_at
Day 3 Peri/Day 3 Intra
0.853
7.0175E−03

586
41869_at
Day 7 Peri/Day 0 Peri
0.831
9.3885E−03

TABLE 3

Diagnostic Down

Gene
Public

ID
Identifier
Data Source
Gene Name

1
4250
Entrez Gene
secretoglobin, family 2A, member 2

3
10647
Entrez Gene
secretoglobin, family 1D, member 2

5
2167
Entrez Gene
fatty acid binding protein 4, adipocyte

11
553168
Entrez Gene
chromosome 1 open reading frame 68

14
3205
Entrez Gene
homeo box A9

15
7136
Entrez Gene
troponin I type 2 (skeletal, fast)

17
6210
Entrez Gene
ribosomal protein S15a

28
10781
Entrez Gene
zinc finger protein 266

29
4128
Entrez Gene
monoamine oxidase A

37
23016
Entrez Gene
exosome component 7

38
23352
Entrez Gene
retinoblastoma-associated factor 600

39
7138
Entrez Gene
troponin T type 1 (skeletal, slow)

42
10521
Entrez Gene
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

43
8710
Entrez Gene
serpin peptidase inhibitor, clade B (ovalbumin),

member 7

46
54
Entrez Gene
acid phosphatase 5, tartrate resistant

49
63928
Entrez Gene
hepatocellular carcinoma antigen gene 520

50
5055
Entrez Gene
serpin peptidase inhibitor, clade B (ovalbumin),

member 2

51
5354
Entrez Gene
proteolipld protein 1 (Pelizaeus-Merzbacher disease,

spastic paraplegia 2, uncomplicated)

52
642
Entrez Gene
bleomycin hydrolase

53
10443
Entrez Gene
Hypothetical gene CG012

54
224
Entrez Gene
aldehyde dehydrogenase 3 family, member A2

55
90634
Entrez Gene
hypothetical gene CG018

59
10001
Entrez Gene
mediator of RNA polymerase II transcription,

subunit 6 homolog (yeast)

60
97
Entrez Gene
acylphosphatase 1, erythrocyte (common) type

63
51097
Entrez Gene
saccharopine dehydrogenase (putative)

64
2217
Entrez Gene
Fc fragment of IgG, receptor, transporter, alpha

65
1983
Entrez Gene
eukaryotic translation initiation factor 5

71
HG3570-
The Institute for
—

HT377
Genomic Research

74
8906
Entrez Gene
adaptor-related protein complex 1, gamma 2 subunit

77
9524
Entrez Gene
glycoprotein, synaptic 2

78
91137
Entrez Gene
hypothetical protein BC017169

79
56288
Entrez Gene
par-3 partitioning defective 3 homolog (C. elegans)

81
260294
Entrez Gene
Williams Beuren syndrome chromosome region 20C

83
131544
Entrez Gene
hypothetical protein DKFZp667G2110

86
10181
Entrez Gene
RNA binding motif protein 5

94
10450
Entrez Gene
peptidylprolyl isomerase E (cyclophilin E)

95
HG1112-
The Institute
—

HT111
for Genomic

Research

99
10314
Entrez Gene
LanC lantibiotic synthetase component C-like 1

(bacterial)

103
10924
Entrez Gene
sphingomyelin phosphodiesterase, acid-like 3A

109
26039
Entrez Gene
synovial sarcoma translocation gene on chromosome

18-like 1

113
6490
Entrez Gene
silver homolog (mouse)

115
4176
Entrez Gene
MCM7 minichromosome maintenance

deficient 7 (S. cerevisiae)

116
2197
Entrez Gene
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV)

ubiquitously expressed (fox derived): ribosomal protein

S30

118
4898
Entrez Gene
nardilysin (N-arginine dibasic convertase)

123
1573
Entrez Gene
cytochrome P450, family 2, subfamily J, polypeptide 2

130
U18300
GenBank
damage-specific DNA binding protein 2, 48 kDa /// LIM

homeobox 3

132
51706
Entrez Gene
cytochrome b5 reductase 1

141
57613
Entrez Gene
KIAA1467 protein

142
2647
Entrez Gene
biogenesis of lysosome-related organelles complex-1,

subunit 1

148
4713
Entrez Gene
NADH dehydrogenase (ubiquinone) 1 beta

subcomplex, 7, 18 kDa

150
771
Entrez Gene
carbonic anhydrase XII

151
55187
Entrez Gene
vacuolar protein sorting 13D (yeast)

152
498
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F1

complex, alpha subunit, isoform 1, cardiac muscle

156
5985
Entrez Gene
replication factor C (activator 1) 5, 36.5 kDa

159
5110
Entrez Gene
Protein-L-isoaspartate (D-aspartate) O-

methyltransferase

160
113146
Entrez Gene
chromosome 14 open reading frame 78

165
10124
Entrez Gene
ADP-ribosylation factor-like 4

166
10653
Entrez Gene
serine peptidase inhibitor, Kunitz type, 2

167
10434
Entrez Gene
lysophospholipase I

170
80308
Entrez Gene
Fad1, flavin adenine dinucleotide synthetase, homolog

(yeast)

173
23345
Entrez Gene
spectrin repeat containing, nuclear envelope 1

175
80208
Entrez Gene
hypothetical protein FLJ21439

180
9927
Entrez Gene
mitofusin 2

182
2145
Entrez Gene
enhancer of zeste homolog 1 (Drosophila)

183
2959
Entrez Gene
general transcription factor IIB

185
4736
Entrez Gene
ribosomal protein L10a

186
644
Entrez Gene
biliverdin reductase A

187
9665
Entrez Gene
limkain b1

191
11336
Entrez Gene
SEC6-like 1 (S. cerevisiae)

192
7009
Entrez Gene
testis enhanced gene transcript (BAX inhibitor 1)

193
23107
Entrez Gene
mitochondrial ribosomal protein S27

194
50
Entrez Gene
aconitase 2, mitochondrial

195
2746
Entrez Gene
glutamate dehydrogenase 1

198
6166
Entrez Gene
ribosomal protein L36a-like

199
7175
Entrez Gene
translocated promoter region (to activated MET

oncogene)

202
10553
Entrez Gene
HIV-1 Tat interactive protein 2, 30 kDa

203
115817
Entrez Gene
dehydrogenase/reductase (SDR family) member 1

205
25963
Entrez Gene
DKFZP564G2022 protein

206
1212
Entrez Gene
clathrin, light polypeptide (Lcb)

207
1652
Entrez Gene
D-dopachrome tautomerase

216
4729
Entrez Gene
NADH dehydrogenase (ubiquinone) flavoprotein 2,

24 kDa

217
987
Entrez Gene
LPS-responsive vesicle trafficking, beach and anchor

containing

222
10980
Entrez Gene
COP9 constitutive photomorphogenic homolog subunit

6 (Arabidopsis)

228
645
Entrez Gene
biliverdin reductase B (flavin reductase (NADPH))

232
10476
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F0

complex, subunit d

233
7022
Entrez Gene
transcription factor AP-2 gamma (activating enhancer

binding protein 2 gamma)

235
23185
Entrez Gene
La ribonucleoprotein domain family, member 5

241
8673
Entrez Gene
vesicle-associated membrane protein 8 (endobrevin)

243
4255
Entrez Gene
O-6-methylguanine-DNA methyltransferase

246
11188
Entrez Gene
nischarin

250
4775
Entrez Gene
nuclear factor of activated T-cells, cytoplasmic,

calcineurin-dependent 3

252
4790
Entrez Gene
nuclear factor of kappa light polypeptide gene

enhancer in B-cells 1 (p105)

254
26135
Entrez Gene
SERPINE1 mRNA binding protein 1

257
AI557912
GenBank
translocase of outer mitochondrial membrane 7

homolog (yeast) /// hypothetical protein LOC201725

259
3550
Entrez Gene
IK cytokine, down-regulator of HLA II

262
353
Entrez Gene
adenine phosphoribosyltransferase

265
79703
Entrez Gene
hypothetical protein FLJ22531

268
513
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F1

complex, delta subunit

269
AL050091
GenBank
glutamate receptor, ionotropic, N-methyl D-aspartate-

like 1A /// GRINL1A combined protein /// similar to

glutamate receptor, ionotropic, N-methyl D-a

275
10497
Entrez Gene
unc-13 homolog B (C. elegans)

277
8560
Entrez Gene
degenerative spermatocyte homolog 1, lipid

desaturase (Drosophila)

278
10975
Entrez Gene
ubiquinol-cytochrome c reductase, 6.4 kDa subunit

279
10641
Entrez Gene
tumor suppressor candidate 4

281
50717
Entrez Gene
WD repeat domain 42A

291
5092
Entrez Gene
6-pyruvoyl-tetrahydropterin synthase/dimerization

cofactor of hepatocyte nuclear factor 1 alpha (TCF1)

292
7818
Entrez Gene
death associated protein 3

294
23063
Entrez Gene
KIAA0261

296
57147
Entrez Gene
SCY1-like 3 (S. cerevisiae)

300
22883
Entrez Gene
calsyntenin 1

301
7520
Entrez Gene
X-ray repair complementing defective repair in

Chinese hamster cells 5 (double-strand-break

rejoining; Ku autoantigen, 80 kDa)

305
23351
Entrez Gene
KIAA0323

306
2065
Entrez Gene
v-erb-b2 erythroblastic leukemia viral oncogene

homolog 3 (avian)

307
10217
Entrez Gene
CTD (carboxy-terminal domain, RNA polymerase II,

polypeptide A) small phosphatase-like

308
23658
Entrez Gene
LSM5 homolog, U6 small nuclear RNA

associated (S. cerevisiae)

309
W28948
GenBank
Full length insert cDNA YH77E09

314
6209
Entrez Gene
ribosomal protein S15

317
10961
Entrez Gene
endoplasmic reticulum protein 29

318
7265
Entrez Gene
tetratricopeptide repeat domain 1

323
9296
Entrez Gene
ATPase, H+ transporting, lysosomal 14 kDa, V1

subunit F

326
1632
Entrez Gene
dodecenoyl-Coenzyme A delta isomerase (3,2 transenoyl-

Coenzyme A isomerase)

328
6141
Entrez Gene
ribosomal protein L18

332
573
Entrez Gene
BCL2-associated athanogene

335
11083
Entrez Gene
death associated transcription factor 1

336
10247
Entrez Gene
heat-responsive protein 12

343
7739
Entrez Gene
zinc finger protein 185 (LIM domain)

348
26211
Entrez Gene
olfactory receptor, family 2, subfamily F, member 1

350
9798
Entrez Gene
KIAA0174

353
4070
Entrez Gene
tumor-associated calcium signal transducer 2

359
4835
Entrez Gene
NAD(P)H dehydrogenase, quinone 2

367
51690
Entrez Gene
LSM7 homolog, U6 small nuclear RNA

associated (S. cerevisiae)

378
10014
Entrez Gene
histone deacetylase 5

380
HG662-HT662
The Institute
—

for Genomic

Research

385
4694
Entrez Gene
NADH dehydrogenase (ubiquinone) 1 alpha

subcomplex, 1, 7.5 kDa

389
8667
Entrez Gene
eukaryotic translation initiation factor 3, subunit 3

gamma, 40 kDa

395
5441
Entrez Gene
polymerase (RNA) II (DNA directed) polypeptide L,

7.6 kDa

404
3028
Entrez Gene
hydroxyacyl-Coenzyme A dehydrogenase, type II

407
6748
Entrez Gene
signal sequence receptor, delta (translocon-associated

protein delta)

411
1537
Entrez Gene
cytochrome c-1

415
64976
Entrez Gene
mitochondrial ribosomal protein L40

418
4676
Entrez Gene
nucleosome assembly protein 1-like 4

431
8337
Entrez Gene
histone 2, H2aa

433
23492
Entrez Gene
chromobox homolog 7

434
4809
Entrez Gene
NHP2 non-histone chromosome protein

2-like 1 (S. cerevisiae)

437
328
Entrez Gene
APEX nuclease (multifunctional DNA repair enzyme) 1

440
533
Entrez Gene
ATPase, H+ transporting, lysosomal 21 kDa, V0

subunit c″

445
4678
Entrez Gene
nuclear autoantigenic sperm protein (histone-binding)

449
57017
Entrez Gene
chromosome 16 open reading frame 49

453
10542
Entrez Gene
hepatitis B virus x interacting protein

459
593
Entrez Gene
branched chain keto acid dehydrogenase E1, alpha

polypeptide (maple syrup urine disease)

463
22870
Entrez Gene
SAPS domain family, member 1

471
6050
Entrez Gene
ribonuclease/angiogenin inhibitor 1

475
U77948
GenBank
general transcription factor II, I /// general transcription

factor II, i, pseudogene 1

480
HG1614-
The Institute
—

HT161
for Genomic

Research

493
10473
Entrez Gene
high mobility group nucleosomal binding domain 4

498
283638
Entrez Gene
KIAA0284

506
10929
Entrez Gene
Splicing factor, arginine/serine-rich, 46 kD

514
3030
Entrez Gene
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-

Coenzyme A thiolase/enoyl-Coenzyme A hydratase

(trifunctional protein), alpha subunit

520
10572
Entrez Gene
CD27-binding (Siva) protein

522
162427
Entrez Gene
hypothetical protein LOC162427

525
55218
Entrez Gene
chromosome 14 open reading frame 114

529
56829
Entrez Gene
zinc finger CCCH-type, antiviral 1

531
6293
Entrez Gene
vacuolar protein sorting 52 (yeast)

542
8890
Entrez Gene
eukaryotic translation initiation factor 2B, subunit 4

delta, 67 kDa

546
29
Entrez Gene
active BCR-related gene

560
23307
Entrez Gene
KIAA0674

567
1201
Entrez Gene
ceroid-lipofuscinosis, neuronal 3, juvenile (Batten,

Spielmeyer-Vogt disease)

577
11258
Entrez Gene
dynactin 3 (p22)

582
5438
Entrez Gene
polymerase (RNA) II (DNA directed) polypeptide I,

14.5 kDa

Gene

Fold

ID
Probe_ID
Comparison
Change
P value

1
36329_at
Day 3 Peri/Day 3 Control
0.131
2.0793E−03

3
32880_at
Day 3 Peri/Day 3 Control
0.211
2.5582E−03

5
38430_at
Day 0 Peri/Day 0 Control
0.219
8.7014E−03

11
31326_at
Day 7 Peri/Day 7 Control
0.138
7.6909E−03

31326_at
Day 3 Peri/Day 3 Control
0.214
6.7718E−03

14
37809_at
Day 3 Peri/Day 3 Control
0.180
5.0202E−03

15
38457_at
Day 0 Peri/Day 0 Control
0.185
5.1425E−04

17
34316_at
Day 3 Peri/Day 3 Control
0.241
3.8100E−05

34316_at
Day 7 Peri/Day 7 Control
0.432
2.3230E−04

28
41621_i_at
Day 0 Peri/Day 0 Control
0.350
5.4116E−04

29
41771_g_at
Day 3 Peri/Day 3 Control
0.464
2.4030E−03

37
33294_at
Day 0 Peri/Day 0 Control
0.369
2.9368E−04

33294_at
Day 3 Peri/Day 3 Control
0.453
3.7416E−04

38
33860_at
Day 0 Peri/Day 0 Control
0.369
5.2550E−04

33860_at
Day 3 Peri/Day 3 Control
0.374
1.4026E−03

33860_at
Day 7 Peri/Day 7 Control
0.452
4.0374E−03

39
36113_s_at
Day 7 Peri/Day 7 Control
0.371
6.4628E−03

36113_s_at
Day 3 Peri/Day 3 Control
0.452
4.3070E−03

42
35363_at
Day 0 Peri/Day 0 Control
0.383
2.2472E−03

43
35577_at
Day 0 Peri/Day 0 Control
0.385
4.8105E−04

46
677_s_at
Day 7 Peri/Day 7 Control
0.389
2.8442E−04

49
33007_at
Day 3 Peri/Day 3 Control
0.394
7.4079E−03

50
37185_at
Day 0 Peri/Day 0 Control
0.399
5.5226E−03

51
41158_at
Day 0 Peri/Day 0 Control
0.544
4.8737E−03

52
394_at
Day 3 Peri/Day 3 Control
0.404
6.8138E−03

53
1532_g_at
Day 0 Peri/Day 0 Control
0.406
9.9594E−04

1532_g_at
Day 3 Peri/Day 3 Control
0.567
4.1852E−03

54
40409_at
Day 3 Peri/Day 3 Control
0.445
7.4233E−03

55
1527_s_at
Day 0 Peri/Day 0 Control
0.410
2.0450E−03

1527_s_at
Day 3 Peri/Day 3 Control
0.515
2.5140E−03

59
35430_at
Day 3 Peri/Day 3 Control
0.427
4.0549E−03

60
33334_at
Day 0 Peri/Day 0 Control
0.427
3.3326E−03

63
34863_s_at
Day 3 Peri/Day 3 Control
0.430
9.0435E−03

64
31431_at
Day 7 Peri/Day 7 Control
0.430
7.9132E−04

65
167_at
Day 3 Peri/Day 3 Control
0.431
3.2376E−04

71
936_s_at
Day 3 Peri/Day 3 Control
0.437
1.3929E−04

936_s_at
Day 7 Peri/Day 7 Control
0.554
6.0851E−03

74
38798_s_at
Day 0 Peri/Day 0 Control
0.441
6.9369E−03

38798_s_at
Day 3 Peri/Day 3 Control
0.480
6.4090E−03

77
38966_at
Day 7 Peri/Day 7 Control
0.444
3.9851E−03

38966_at
Day 3 Peri/Day 3 Control
0.530
1.4148E−03

78
37178_at
Day 3 Peri/Day 3 Control
0.449
3.9314E−03

79
40973_at
Day 0 Peri/Day 0 Control
0.451
2.5568E−03

81
41258_at
Day 0 Peri/Day 0 Control
0.453
3.7268E−03

83
41274_at
Day 0 Peri/Day 0 Control
0.454
4.4963E−03

41274_at
Day 3 Peri/Day 3 Control
0.589
7.6530E−03

86
1556_at
Day 0 Peri/Day 0 Control
0.460
1.4047E−03

94
34365_at
Day 3 Peri/Day 3 Control
0.473
5.7231E−03

95
1839_at
Day 3 Peri/Day 3 Control
0.555
9.8116E−03

99
39441_at
Day 0 Peri/Day 0 Control
0.482
2.7594E−03

103
39950_at
Day 3 Peri/Day 3 Control
0.483
8.6125E−03

109
31903_at
Day 0 Peri/Day 0 Control
0.493
1.3274E−03

113
38327_at
Day 3 Peri/Day 3 Control
0.512
5.3933E−04

115
947_at
Day 0 Peri/Day 0 Control
0.498
7.8436E−04

116
31955_at
Day 7 Peri/Day 7 Control
0.498
8.3003E−03

118
34787_at
Day 3 Peri/Day 3 Control
0.499
2.6275E−03

123
501_g_at
Day 3 Peri/Day 3 Control
0.505
2.0051E−03

130
1243_at
Day 3 Peri/Day 3 Control
0.511
4.6848E−04

1243_at
Day 0 Peri/Day 0 Control
0.556
6.7443E−03

132
35329_at
Day 3 Peri/Day 3 Control
0.513
1.8894E−03

141
41826_at
Day 0 Peri/Day 0 Control
0.520
5.9389E−03

142
39133_at
Day 7 Peri/Day 7 Control
0.520
1.5729E−03

148
35773_i_at
Day 7 Peri/Day 7 Control
0.525
1.8840E−03

150
36454_at
Day 0 Peri/Day 0 Control
0.526
3.3461E−03

151
32743_at
Day 0 Peri/Day 0 Control
0.619
1.5268E−03

152
40096_at
Day 3 Peri/Day 3 Control
0.527
6.5302E−03

40096_at
Day 0 Peri/Day 0 Control
0.563
2.0338E−04

156
653_at
Day 0 Peri/Day 0 Control
0.533
6.1850E−03

159
37738_g_at
Day 3 Peri/Day 3 Control
0.678
3.6789E−03

160
36497_at
Day 3 Peri/Day 3 Control
0.535
3.4244E−03

165
33796_at
Day 3 Peri/Day 3 Control
0.537
6.8833E−03

166
34348_at
Day 3 Peri/Day 3 Control
0.537
9.4449E−03

34348_at
Day 0 Peri/Day 0 Control
0.573
7.9326E−03

167
39396_at
Day 3 Peri/Day 3 Control
0.541
7.9687E−03

170
39074_at
Day 3 Peri/Day 3 Control
0.544
3.5087E−04

173
38113_at
Day 0 Peri/Day 0 Control
0.546
1.8607E−03

175
40615_at
Day 0 Peri/Day 0 Control
0.546
5.1650E−03

180
34369_at
Day 3 Peri/Day 3 Control
0.549
2.5016E−03

182
32259_at
Day 3 Peri/Day 3 Control
0.593
1.0957E−03

183
1070_at
Day 3 Peri/Day 3 Control
0.556
4.5246E−03

185
36786_at
Day 7 Peri/Day 7 Control
0.592
1.4203E−03

36786_at
Day 3 Peri/Day 3 Control
0.622
8.0958E−04

36786_at
Day 0 Peri/Day 0 Control
0.668
3.0374E−03

186
32618_at
Day 3 Peri/Day 3 Control
0.557
3.0605E−04

32618_at
Day 0 Peri/Day 0 Control
0.677
7.9770E−03

187
31936_s_at
Day 3 Peri/Day 3 Control
0.558
3.7112E−03

191
37597_s_at
Day 3 Peri/Day 3 Control
0.560
4.7635E−03

192
33988_at
Day 3 Peri/Day 3 Control
0.560
1.0937E−03

193
39377_at
Day 3 Peri/Day 3 Control
0.571
9.8955E−03

194
160044_g_at
Day 3 Peri/Day 3 Control
0.562
5.6984E−03

195
31691_g_at
Day 3 Peri/Day 3 Control
0.563
6.9886E−03

198
39856_at
Day 0 Peri/Day 0 Control
0.568
7.8476E−03

199
421_at
Day 0 Peri/Day 0 Control
0.569
3.6369E−03

202
38824_at
Day 3 Peri/Day 3 Control
0.571
7.2789E−03

203
39103_s_at
Day 3 Peri/Day 3 Control
0.571
2.1724E−04

205
40437_at
Day 3 Peri/Day 3 Control
0.572
3.2143E−03

206
32523_at
Day 3 Peri/Day 3 Control
0.573
4.0809E−03

207
374_f_at
Day 7 Peri/Day 7 Control
0.573
7.7105E−03

216
34893_at
Day 7 Peri/Day 7 Control
0.581
9.2931E−03

217
35371_at
Day 3 Peri/Day 3 Control
0.582
1.9359E−03

222
40138_at
Day 7 Peri/Day 7 Control
0.584
6.5665E−03

228
37002_at
Day 7 Peri/Day 7 Control
0.588
8.3451E−04

232
35760_at
Day 0 Peri/Day 0 Control
0.738
8.9277E−03

233
40303_at
Day 3 Peri/Day 3 Control
0.591
7.9662E−03

235
32586_at
Day 0 Peri/Day 0 Control
0.591
3.7384E−03

32586_at
Day 3 Peri/Day 3 Control
0.685
8.4169E−04

241
32715_at
Day 0 Peri/Day 0 Control
0.628
1.3473E−03

243
2051_at
Day 7 Peri/Day 7 Control
0.594
5.4697E−03

246
33916_at
Day 0 Peri/Day 0 Control
0.595
3.7132E−03

33916_at
Day 3 Peri/Day 3 Control
0.647
6.0432E−03

250
40822_at
Day 0 Peri/Day 0 Control
0.597
3.4027E−03

252
1378_g_at
Day 0 Peri/Day 0 Control
0.646
7.6400E−03

254
40440_at
Day 0 Peri/Day 0 Control
0.599
7.7405E−03

257
39025_at
Day 7 Peri/Day 7 Control
0.716
2.2149E−03

259
218_at
Day 3 Peri/Day 3 Control
0.606
4.9835E−04

262
34310_at
Day 3 Peri/Day 3 Control
0.607
7.6231E−03

265
41804_at
Day 3 Peri/Day 3 Control
0.608
1.1934E−04

268
37992_s_at
Day 7 Peri/Day 7 Control
0.611
6.2111E−03

269
35736_at
Day 0 Peri/Day 0 Control
0.611
4.7952E−03

275
40087_at
Day 3 Peri/Day 3 Control
0.614
3.7491E−03

277
33337_at
Day 3 Peri/Day 3 Control
0.614
8.5255E−03

33337_at
Day 7 Peri/Day 7 Control
0.626
3.0395E−03

278
38451_at
Day 7 Peri/Day 7 Control
0.614
8.2100E−05

279
40497_at
Day 0 Peri/Day 0 Control
0.614
9.7424E−03

40497_at
Day 3 Peri/Day 3 Control
0.655
1.1667E−04

281
39823_at
Day 3 Peri/Day 3 Control
0.616
2.9015E−03

291
34352_at
Day 7 Peri/Day 7 Control
0.620
2.4354E−03

292
1356_at
Day 0 Peri/Day 0 Control
0.621
1.4788E−03

294
40086_at
Day 3 Peri/Day 3 Control
0.623
5.5939E−03

296
41329_at
Day 3 Peri/Day 3 Control
0.624
2.9063E−03

300
41498_at
Day 3 Peri/Day 3 Control
0.626
9.2124E−04

301
2093_s_at
Day 3 Peri/Day 3 Control
0.627
1.0646E−03

38733_at
Day 0 Peri/Day 0 Control
0.644
9.6568E−03

305
32592_at
Day 0 Peri/Day 0 Control
0.628
8.9436E−04

306
2089_s_at
Day 0 Peri/Day 0 Control
0.629
5.0250E−03

307
40196_at
Day 3 Peri/Day 3 Control
0.630
3.3471E−03

308
34270_at
Day 3 Peri/Day 3 Control
0.631
1.9266E−03

309
37161_at
Day 3 Peri/Day 3 Control
0.640
6.9170E−03

314
39916_r_at
Day 7 Peri/Day 7 Control
0.633
1.4158E−03

39916_r_at
Day 3 Peri/Day 3 Control
0.675
7.7101E−03

317
36945_at
Day 3 Peri/Day 3 Control
0.635
9.2309E−04

318
37321_at
Day 3 Peri/Day 3 Control
0.635
7.5603E−03

323
37395_at
Day 7 Peri/Day 7 Control
0.638
2.2448E−03

37395_at
Day 3 Peri/Day 3 Control
0.722
8.6817E−04

326
37982_at
Day 7 Peri/Day 7 Control
0.639
2.3722E−03

328
31546_at
Day 7 Peri/Day 7 Control
0.639
6.9963E−03

332
34798_at
Day 3 Peri/Day 3 Control
0.642
4.4022E−03

335
32045_at
Day 0 Peri/Day 0 Control
0.644
6.8658E−03

336
32173_at
Day 3 Peri/Day 3 Control
0.659
6.9500E−03

343
32139_at
Day 0 Peri/Day 0 Control
0.648
5.7560E−03

348
31921_at
Day 3 Peri/Day 3 Control
0.652
2.1176E−03

350
36942_at
Day 0 Peri/Day 0 Control
0.653
5.6656E−03

353
291_s_at
Day 0 Peri/Day 0 Control
0.654
9.5683E−03

359
36880_at
Day 7 Peri/Day 7 Control
0.657
7.2935E−03

367
36846_s_at
Day 7 Peri/Day 7 Control
0.662
8.8105E−04

378
38810_at
Day 3 Peri/Day 3 Control
0.667
1.7702E−04

380
1151_at
Day 3 Peri/Day 3 Control
0.669
1.5550E−03

385
36169_at
Day 3 Peri/Day 3 Control
0.671
5.9310E−04

36169_at
Day 7 Peri/Day 7 Control
0.710
9.3036E−03

389
35327_at
Day 3 Peri/Day 3 Control
0.672
5.0660E−03

395
35841_at
Day 7 Peri/Day 7 Control
0.676
2.4659E−03

404
40778_at
Day 3 Peri/Day 3 Control
0.683
9.5528E−03

40778_at
Day 0 Peri/Day 0 Control
0.700
6.7401E−03

407
38635_at
Day 7 Peri/Day 7 Control
0.684
3.2000E−03

411
1160_at
Day 3 Peri/Day 3 Control
0.685
9.9616E−03

415
32745_at
Day 3 Peri/Day 3 Control
0.688
7.4413E−03

418
32575_at
Day 3 Peri/Day 3 Control
0.689
7.9600E−05

431
286_at
Day 3 Peri/Day 3 Control
0.693
7.8013E−03

433
36894_at
Day 3 Peri/Day 3 Control
0.693
8.8784E−03

434
41746_at
Day 3 Peri/Day 3 Control
0.693
5.4886E−03

437
2025_s_at
Day 3 Peri/Day 3 Control
0.695
4.9002E−03

440
36167_at
Day 7 Peri/Day 7 Control
0.696
9.2513E−03

445
33255_at
Day 3 Peri/Day 3 Control
0.696
9.0975E−03

449
34810_at
Day 7 Peri/Day 7 Control
0.700
1.2592E−03

453
38054_at
Day 3 Peri/Day 3 Control
0.704
9.1709E−03

459
37704_at
Day 3 Peri/Day 3 Control
0.707
1.4726E−03

463
36862_at
Day 3 Peri/Day 3 Control
0.709
6.5040E−03

471
36187_at
Day 3 Peri/Day 3 Control
0.730
5.3879E−03

475
35450_s_at
Day 0 Peri/Day 0 Control
0.718
8.5556E−03

480
954_s_at
Day 7 Peri/Day 7 Control
0.722
8.4646E−03

493
35738_at
Day 3 Peri/Day 3 Control
0.732
4.8156E−03

498
38592_s_at
Day 3 Peri/Day 3 Control
0.788
5.7373E−03

506
32038_s_at
Day 3 Peri/Day 3 Control
0.740
6.3052E−03

514
36952_at
Day 0 Peri/Day 0 Control
0.835
2.4582E−03

520
39020_at
Day 3 Peri/Day 3 Control
0.754
9.5129E−03

522
38423_at
Day 0 Peri/Day 0 Control
0.755
7.1257E−03

525
35283_at
Day 0 Peri/Day 0 Control
0.759
7.7904E−04

529
35682_at
Day 3 Peri/Day 3 Control
0.761
2.0789E−04

531
32658_at
Day 0 Peri/Day 0 Control
0.762
7.4217E−03

542
32659_at
Day 3 Peri/Day 3 Control
0.768
8.3725E−03

546
39058_at
Day 3 Peri/Day 3 Control
0.771
7.8298E−03

560
31826_at
Day 0 Peri/Day 0 Control
0.783
2.4933E−03

567
497_at
Day 3 Peri/Day 3 Control
0.792
5.8473E−03

577
40410_at
Day 3 Peri/Day 3 Control
0.808
6.4549E−03

582
34828_at
Day 0 Peri/Day 0 Control
0.816
8.6878E−03

TABLE 4

Diagnostic Down

Gene
Public

Fold

ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Change
P value

166
10653
Entrez Gene
serine peptidase inhibitor, Kunitz type, 2
34348_at
Day 3 Peri/Day 3 Control
0.537
9.4449E−03

34348_at
Day 0 Peri/Day 0 Control
0.573
7.9326E−03

TABLE 5

Diagnostic Down

Public

Gene ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Fold Change
P value

141
57613
Entrez Gene
KIAA1467 protein
41826_at
Day 0 Peri/Day 0 Control
0.520
5.9389E−03

300
22883
Entrez Gene
calsyntenin 1
41498_at
Day 3 Peri/Day 3 Control
0.626
9.2124E−04

TABLE 6

Diagnostic Down

Public

Gene ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Fold Change
P value

250
4775
Entrez Gene
nuclear factor of activated T-cells,
40822_at
Day 0 Peri/Day 0 Control
0.597
3.4027E−03

cytoplasmic, calcineurin-dependent 3

252
4790
Entrez Gene
nuclear factor of kappa light
1378_g_at
Day 0 Peri/ Day 0 Control
0.646
7.6400E−03

polypeptide gene enhancer in

8-cells 1 (p105)

378
10014
Entrez Gene
histone deacetylase 5
38810_at
Day 3 Peri/Day 3 Control
0.667
1.7702E−04

TABLE 7

Diagnostic Down

Public

Gene ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Fold Change
P value

202
10553
Entrez Gene
HIV-1 Tat interactive protein 2,
38824_at
Day 3 Peri/Day 3 Control
0.571
7.2789E−03

30 kDa

TABLE 8

Diagnostic Down

Public

Gene ID
Identifier
Data Source
Gene Name

11
553168
Entrez Gene
chromosome 1 open reading frame 68

14
3205
Entrez Gene
homeo box A9

17
6210
Entrez Gene
ribosomal protein S15a

22
M57951
GenBank
UDP glucuronosyltransferase 1 family, polypeptide

A10 /// UDP glucuronosyltransferase 1 family,

polypeptide A8 /// UDP glucuronosyltransferase 1

fami

26
5271
Entrez Gene
serpin peptidase inhibitor, clade B (ovalbumin),

member 8

29
4128
Entrez Gene
monoamine oxidase A

38
23352
Entrez Gene
retinoblastoma-associated factor 600

42
10521
Entrez Gene
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

45
3202
Entrez Gene
homeo box A5

46
54
Entrez Gene
acid phosphatase 5, tartrate resistant

58
10158
Entrez Gene
PDZK1 interacting protein 1

65
1983
Entrez Gene
eukaryotic translation initiation factor 5

70
2618
Entrez Gene
phosphoribosylglycinamide formyltransferase,

phosphoribosylglycinamide synthetase,

phosphoribosylaminoimidazole synthetase

72
53335
Entrez Gene
B-cell CLL/lymphoma 11A (zinc finger protein)

80
26154
Entrez Gene
ATP-binding cassette, sub-family A (ABC1), member

12

82
1410
Entrez Gene
crystallin, alpha B

84
10733
Entrez Gene
polo-like kinase 4 (Drosophila)

95
HG1112-
The Institute for
—

HT111
Genomic Research

97
4129
Entrez Gene
monoamine oxidase B

106
8634
Entrez Gene
RNA terminal phosphate cyclase domain 1

108
7262
Entrez Gene
pleckstrin homology-like domain, family A, member 2

110
1525
Entrez Gene
coxsackie virus and adenovirus receptor

112
11072
Entrez Gene
dual specificity phosphatase 14

113
6490
Entrez Gene
silver homolog (mouse)

119
6662
Entrez Gene
SRY (sex determining region Y)-box 9 (campomelic

dysplasia, autosomal sex-reversal)

120
2114
Entrez Gene
v-ets erythroblastosis virus E26 oncogene homolog 2

(avian)

129
9833
Entrez Gene
maternal embryonic leucina zipper kinase

136
2013
Entrez Gene
epithelial membrane protein 2

144
AF096870
GenBank
tripartite motif-containing 16 /// similar to tripartite

motif-containing 16; estrogen-responsive B box

protein

150
771
Entrez Gene
carbonic anhydrase XII

154
242
Entrez Gene
arachidonate 12-lipoxygenase, 12R type

169
123
Entrez Gene
adipose differentiation-related protein

176
202
Entrez Gene
absent in melanoma 1

178
5268
Entrez Gene
serpin peptidase inhibitor, clade B (ovalbumin),

members 5

180
9927
Entrez Gene
mitofusin 2

185
4736
Entrez Gene
ribosomal protein L10a

186
644
Entrez Gene
biliverdin reductase A

188
3033
Entrez Gene
L-3-hydroxyacyl-Coenzyme A dehydrogenase, short

chain

190
55651
Entrez Gene
nucleolar protein family A, member 2 (H/ACA small

nucleolar RNPs)

191
11336
Entrez Gene
SEC6-llke 1 (S. cerevisiae)

192
7009
Entrez Gene
testis enhanced gene transcript (BAX inhibitor 1)

193
23107
Entrez Gene
mitochondrial ribosomal protein S27

201
171546
Entrez Gene
chromosome 14 open reading frame 147

202
10553
Entrez Gene
HIV-1 Tat interactive protein 2, 30 kDa

203
115817
Entrez Gene
dehydrogenase/reductase (SDR family) member 1

204
25813
Entrez Gene
sorting and assembly machinery component 50

homolog (s. cerevisiae)

208
27335
Entrez Gene
eukaryotic translation Initiation factor 3, subunit 12

209
217
Entrez Gene
aldehyde dehydrogenase 2 family (mitochondrial)

210
10049
Entrez Gene
DnaJ (Hsp40) homolog, subfamily 8, member 6

214
11066
Entrez Gene
U11/U12 snRNP 35K

216
4729
Entrez Gene
NADH dehydrogenase (ubiquinone) flavoprotein 2,

24 kDa

217
987
Entrez Gene
LPS-responsive vesicle trafficking, beach and anchor

containing

220
7295
Entrez Gene
thioredoxin

229
8581
Entrez Gene
lymphocyte antigen 6 complex, locus D

232
10476
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F0

complex, subunit d

234
2806
Entrez Gene
glutamic-oxaloacetic transaminase 2, mitochondrial

(aspartate aminotransferase 2)

235
23185
Entrez Gene
La ribonucleoprotein domain family, member 5

237
708
Entrez Gene
complement component 1, q subcomponent binding

protein

238
81875
Entrez Gene
interferon stimulated exonuclease gene 20 kDa-like 2

239
AI032612
GenBank
enolase 1, (alpha) /// small nuclear ribonucleoprotein

polypeptide F

241
8673
Entrez Gene
vesicle-associated membrane protein 8 (endobrevin)

245
6249
Entrez Gene
restin (Reed-Steinberg cell-expressed intermediate

filament-associated protein)

248
2547
Entrez Gene
X-ray repair complementing defective repair in

Chinese hamster cells 6 (Ku autoantigen, 70 kDa)

249
545
Entrez Gene
ataxia telangiectasia and Rad3 related

250
4775
Entrez Gene
nuclear factor of activated T-cells, cytoplasmic,

calcineurin-dependent 3

252
4790
Entrez Gene
nuclear factor of kappa light polypeptide gene

enhancer in B-cells 1 (p105)

255
23234
Entrez Gene
DnaJ (Hsp40) homolog, subfamily C, member 9

258
4437
Entrez Gene
mutS homolog 3 (E. coli)

263
6427
Entrez Gene
splicing factor, arginine/serine-rich 2

266
27292
Entrez Gene
dimethyladenosine transferase

271
9349
Entrez Gene
ribosomal protein L23

280
8663
Entrez Gene
eukaryotic translation initiation factor 3, subunit 8,

110 kDa

286
8665
Entrez Gene
eukaryotic translation initiation factor 3, subunit 5

epsilon, 47 kDa

287
7203
Entrez Gene
chaperonin containing TCP1, subunit 3 (gamma)

293
U05861
GenBank
aldo-keto reductase family 1, member C1

(dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-

hydroxysteroid dehydrogenase) /// aldo-keto

reductase family

295
9529
Entrez Gene
BCL2-associated athanogene 5

299
9536
Entrez Gene
prostaglandin E synthase

303
4928
Entrez Gene
nucleoporin 98 kDa

309
W28948
GenBank
Full length insert cDNA YH77E09

321
6128
Entrez Gene
ribosomal protein L6

322
5245
Entrez Gene
prohibitin

323
9296
Entrez Gene
ATPase, H+ transporting, lysosomal 14 kDa, V1

subunit F

324
1340
Entrez Gene
cytochrome c oxidase subunit Vib polypeptide 1

(ubiquitous)

325
1891
Entrez Gene
enoyl Coenzyme A hydratase 1, peroxisomal

327
1933
Entrez Gene
eukaryotic translation elongation factor 1 beta 2

328
6141
Entrez Gene
ribosomal protein L18

330
6950
Entrez Gene
t-complex 1

331
29760
Entrez Gene
B-cell linker

336
10247
Entrez Gene
heat-responsive protein 12

338
899
Entrez Gene
cyclin F

340
6139
Entrez Gene
ribosomal protein L17

341
9521
Entrez Gene
eukaryotic translation elongation factor 1 epsilon 1

342
1054
Entrez Gene
CCAAT/enhancer binding protein (C/EBP), gamma

344
8664
Entrez Gene
eukaryotic translation initiation factor 3, subunit 7

zeta, 66/67 kDa

345
57418
Entrez Gene
WD repeat domain 18

346
6187
Entrez Gene
ribosomal protein S2

347
11079
Entrez Gene
RER1 retention in endoplasmic reticulum 1 homolog

(S. cerevisiae)

349
6206
Entrez Gene
ribosomal protein S12

353
4070
Entrez Gene
tumor-associated calcium signal transducer 2

354
7152
Entrez Gene
topoisomerase (DNA) I pseudogene 2

355
4615
Entrez Gene
myeloid differentiation primary response gene (88)

357
9377
Entrez Gene
cytochrome c oxidase subunit Va

358
7386
Entrez Gene
ubiquinol-cytochrome c reductase, Rieske iron-sulfur

polypeptide 1

362
HG1980-
The Institute for
—

HT202
Genomic Research

364
54107
Entrez Gene
polymerase (DNA directed), epsilon 3 (p17 subunit)

368
5936
Entrez Gene
RNA binding motif protein 4

369
7004
Entrez Gene
TEA domain family member 4

370
3094
Entrez Gene
histidine triad nucleotide binding protein 1

372
10557
Entrez Gene
ribonuclease P/MRP 38 kDa subunit

373
26156
Entrez Gene
ribosomal L1 domain containing 1

374
6122
Entrez Gene
ribosomal protein L3

381
10694
Entrez Gene
chaperonin containing TCP1, subunit 8 (theta)

385
4694
Entrez Gene
NADH dehydrogenase (ubiquinone) 1 alpha

subcomplex, 1, 7.5 kDa

388
10682
Entrez Gene
emopamil binding protein (sterol isomerase)

396
2146
Entrez Gene
enhancer of zeste homolog 2 (Drosophila)

398
2950
Entrez Gene
glutathione S-transferase pl

401
6156
Entrez Gene
ribosomal protein L30

402
516
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F0

complex, subunit c (subunit 9), isoform 1

403
9128
Entrez Gene
PRP4 pre-mRNA processing factor 4 homolog

(yeast)

404
3028
Entrez Gene
hydroxyacyl-Coenzyme A dehydrogenase, type II

405
2961
Entrez Gene
general transcription factor IIE, polypeptide 2, beta

34 kDa

406
10969
Entrez Gene
EBNA1 binding protein 2

412
6768
Entrez Gene
suppression of tumorigenicity 14 (colon carcinoma,

matriptase, epithin)

420
6390
Entrez Gene
succinate dehydrogenase complex, subunit B, iron

sulfur (Ip)

421
162
Entrez Gene
adaptor-related protein complex 1, beta 1 subunit

423
6749
Entrez Gene
structure specific recognition protein 1

425
6832
Entrez Gene
suppressor of var1, 3-like 1 (S. cerevisiae)

426
10939
Entrez Gene
AFG3 ATPase family gene 3-like 2 (yeast)

432
6193
Entrez Gene
ribosomal protein S5

437
328
Entrez Gene
APEX nuclease (multifunctional DNA repair enzyme) 1

441
4717
Entrez Gene
NADH dehydrogenase (ubiquinone) 1, subcomplex

unknown, 1, 6 kDa

442
23385
Entrez Gene
nicastrin

446
1847
Entrez Gene
dual specificity phosphatase 5

455
694
Entrez Gene
B-cell translocation gene 1, anti-proliferative

459
593
Entrez Gene
branched chain keto acid dehydrogenase E1, alpha

polypeptide (maple syrup urine disease)

462
51635
Entrez Gene
dehydrogenase/reductase (SDR family) member 7

465
613
Entrez Gene
breakpoint cluster region

466
7150
Entrez Gene
topoisomerase (DNA) I

467
1329
Entrez Gene
cytochrome c oxidase subunit Vb

469
6888
Entrez Gene
transaldolase 1

471
6050
Entrez Gene
ribonuclease/angiogenin inhibitor 1

484
26578
Entrez Gene
osteoclast stimulating factor 1

485
1347
Entrez Gene
cytochrome c oxidase subunit VIIa polypeptide 2

(liver)

486
3615
Entrez Gene
IMP (inosine monophosphate) dehydrogenase 2

491
3916
Entrez Gene
lysosomal-associated membrane protein 1

492
23020
Entrez Gene
activating signal cointegrator 1 complex subunit 3-like 1

495
6812
Entrez Gene
syntaxin binding protein 1

496
23511
Entrez Gene
nucleoporin 188 kDa

498
283638
Entrez Gene
KIAA0284

499
30968
Entrez Gene
stomatin (EPB72)-like 2

502
3420
Entrez Gene
isocitrate dehydrogenase 3 (NAD+) beta

512
1327
Entrez Gene
cytochrome c oxidase subunit IV isoform 1

514
3030
Entrez Gene
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-

Coenzyme A thiolase/enoyl-Coenzyme A hydratase

(trifunctional protein), alpha subunit

516
3032
Entrez Gene
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-

Coenzyme A thiolase/enoyl-Coenzyme A hydratase

(trifunctional protein), beta subunit

517
5223
Entrez Gene
phosphoglycerate mutase 1 (brain)

523
10036
Entrez Gene
chromatin assembly factor 1, subunit A (p150)

534
5437
Entrez Gene
polymerase (RNA) II (DNA directed) polypeptide H

536
55744
Entrez Gene
hypothetical protein FLJ10803

544
7529
Entrez Gene
tyrosine 3-monooxygenase/tryptophan 5-

monooxygenase activation protein, beta polypeptide

546
29
Entrez Gene
active BCR-related gene

553
8480
Entrez Gene
RAE1 RNA export 1 homolog (S. pombe)

571
3151
Entrez Gene
high-mobility group nucleosomal binding domain 2

585
7534
Entrez Gene
tyrosine 3-monooxygenase/tryptophan 5-

monooxygenase activation protein, zeta polypeptide

Gene ID
Probe_ID
Comparison
Fold Change
P value

11
31326_at
Day 7 Peri/Day 7 Extra
0.288
7.6740E−03

14
37809_at
Day 7 Peri/Day 7 Extra
0.237
8.7426E−03

37809_at
Day 3 Peri/Day 3 Extra
0.314
9.1991E−03

17
34316_at
Day 3 Peri/Day 3 Extra
0.476
1.6785E−04

22
32392_s_at
Day 3 Peri/Day 3 Extra
0.320
3.1014E−03

26
36312_at
Day 7 Peri/Day 7 Extra
0.331
4.7432E−04

29
41772_at
Day 3 Peri/Day 3 Extra
0.351
3.2109E−03

41772_at
Day 7 Peri/Day 7 Extra
0.614
6.2007E−03

38
33860_at
Day 3 Peri/Day 3 Extra
0.549
6.8632E−03

33860_at
Day 7 Peri/Day 7 Extra
0.579
3.6353E−03

42
35363_at
Day 7 Peri/Day 7 Extra
0.577
6.8649E−03

45
873_at
Day 3 Peri/Day 3 Extra
0.387
6.1920E−03

46
677_s_at
Day 7 Peri/Day 7 Extra
0.672
8.0184E−03

58
31610_at
Day 3 Peri/Day 3 Extra
0.421
4.1131E−03

65
167_at
Day 7 Peri/Day 7 Extra
0.519
7.0199E−03

70
38384_at
Day 3 Peri/Day 3 Extra
0.436
8.9104E−03

72
41356_at
Day 3 Peri/Day 3 Extra
0.438
5.3163E−03

80
31754_at
Day 3 Peri/Day 3 Extra
0.453
4.6700E−03

82
32242_at
Day 3 Peri/Day 3 Extra
0.454
8.8596E−03

84
975_at
Day 7 Peri/Day 7 Extra
0.459
4.3469E−03

95
1839_at
Day 3 Peri/Day 3 Extra
0.473
1.6274E−03

97
37628_at
Day 3 Peri/Day 3 Extra
0.475
8.4099E−04

106
35195_at
Day 7 Peri/Day 7 Extra
0.489
1.6326E−03

108
31888_s_at
Day 3 Peri/Day 3 Extra
0.490
4.0424E−03

110
37534_at
Day 3 Peri/Day 3 Extra
0.493
7.3178E−03

112
38272_at
Day 7 Peri/Day 7 Extra
0.494
1.4839E−03

113
38327_at
Day 3 Peri/Day 3 Extra
0.497
4.4983E−04

119
33436_at
Day 3 Peri/Day 3 Extra
0.500
5.3219E−03

120
38739_at
Day 3 Peri/Day 3 Extra
0.501
4.4662E−03

129
38847_at
Day 7 Peri/Day 7 Extra
0.510
9.6404E−03

136
39631_at
Day 3 Peri/Day 3 Extra
0.517
3.1103E−03

144
38881_i_at
Day 3 Peri/Day 3 Extra
0.521
1.0549E−04

150
35275_at
Day 3 Peri/Day 3 Extra
0.650
2.8445E−03

154
33029_at
Day 7 Peri/Day 7 Extra
0.530
9.3336E−03

169
34378_at
Day 7 Peri/Day 7 Extra
0.542
1.2411E−03

176
32112_s_at
Day 3 Peri/Day 3 Extra
0.547
1.9891E−03

178
862_at
Day 3 Peri/Day 3 Extra
0.548
8.5245E−03

862_at
Day 7 Peri/Day 7 Extra
0.576
5.9941E−03

180
34369_at
Day 3 Peri/Day 3 Extra
0.635
6.4361E−03

185
36786_at
Day 3 Peri/Day 3 Extra
0.556
7.2273E−04

186
32618_at
Day 3 Peri/Day 3 Extra
0.620
3.2960E−04

188
35435_s_at
Day 3 Peri/Day 3 Extra
0.558
7.5277E−03

35435_at
Day 7 Peri/Day 7 Extra
0.692
5.5220E−03

190
41322_s_at
Day 3 Peri/Day 3 Extra
0.559
1.2634E−03

191
37597_s_at
Day 3 Peri/Day 3 Extra
0.566
9.6420E−04

192
33988_at
Day 3 Peri/Day 3 Extra
0.582
8.2347E−04

193
39377_at
Day 3 Peri/Day 3 Extra
0.561
3.7750E−03

201
33399_at
Day 3 Peri/Day 3 Extra
0.571
4.6866E−03

202
38824_at
Day 3 Peri/Day 3 Extra
0.592
5.7073E−03

203
39103_s_at
Day 3 Peri/Day 3 Extra
0.601
5.7200E−03

204
34845_at
Day 3 Peri/Day 3 Extra
0.572
1.2889E−03

208
31492_at
Day 3 Peri/Day 3 Extra
0.574
7.4544E−04

209
32747_at
Day 3 Peri/Day 3 Extra
0.574
5.1549E−04

210
41234_at
Day 7 Peri/Day 7 Extra
0.577
3.8743E−03

214
41029_at
Day 3 Peri/Day 3 Extra
0.580
1.0146E−03

216
34893_at
Day 7 Peri/Day 7 Extra
0.600
1.3243E−03

217
35371_at
Day 3 Peri/Day 3 Extra
0.618
2.4693E−03

220
36992_at
Day 3 Peri/Day 3 Extra
0.583
3.0827E−03

229
36284_at
Day 7 Peri/Day 7 Extra
0.589
9.2936E−03

232
35760_at
Day 3 Peri/Day 3 Extra
0.590
1.5912E−03

234
40764_at
Day 3 Peri/Day 3 Extra
0.591
2.0500E−03

235
32585_at
Day 3 Peri/Day 3 Extra
0.782
5.1596E−03

237
37668_at
Day 3 Peri/Day 3 Extra
0.591
6.3705E−03

238
40946_at
Day 3 Peri/Day 3 Extra
0.593
3.2988E−03

239
41403_at
Day 3 Peri/Day 3 Extra
0.593
2.1695E−03

41403_at
Day 7 Peri/Day 7 Extra
0.674
9.8788E−04

241
32715_at
Day 3 Peri/Day 3 Extra
0.593
2.2624E−03

245
34350_at
Day 7 Peri/Day 7 Extra
0.595
8.1420E−03

248
32766_at
Day 3 Peri/Day 3 Extra
0.597
8.7735E−04

249
37229_at
Day 7 Peri/Day 7 Extra
0.619
5.1546E−03

250
40823_s_at
Day 3 Peri/Day 3 Extra
0.633
7.3198E−03

252
1378_g_at
Day 3 Peri/Day 3 Extra
0.598
6.5881E−03

255
41569_at
Day 7 Peri/Day 7 Extra
0.599
4.9293E−03

258
1719_at
Day 3 Peri/Day 3 Extra
0.603
6.7926E−03

263
36111_s_at
Day 7 Peri/Day 7 Extra
0.607
1.0792E−03

266
39883_at
Day 7 Peri/Day 7 Extra
0.609
2.6811E−03

271
32395_r_at
Day 3 Peri/Day 3 Extra
0.611
2.2508E−03

280
34841_at
Day 3 Peri/ Day 3 Extra
0.615
9.0352E−03

286
32576_at
Day 3 Peri/Day 3 Extra
0.617
4.1860E−03

287
40774_at
Day 3 Peri/Day 3 Extra
0.617
6.5552E−03

293
32805_at
Day 3 Peri/Day 3 Extra
0.621
6.7226E−03

295
36463_at
Day 3 Peri/Day 3 Extra
0.624
7.6918E−03

299
38131_at
Day 3 Peri/Day 3 Extra
0.626
9.0721E−03

303
38911_at
Day 3 Peri/Day 3 Extra
0.627
2.3405E−03

309
37161_at
Day 3 Peri/Day 3 Extra
0.631
4.5494E−03

321
31952_at
Day 3 Peri/Day 3 Extra
0.637
8.7667E−03

322
36592_at
Day 3 Peri/Day 3 Extra
0.637
3.4444E−03

323
37395_at
Day 3 Peri/Day 3 Extra
0.810
7.4746E−03

324
40872_at
Day 3 Peri/Day 3 Extra
0.638
1.3105E−03

325
32756_at
Day 3 Peri/Day 3 Extra
0.638
8.7097E−03

327
35748_at
Day 3 Peri/Day 3 Extra
0.639
7.6265E−04

328
31546_at
Day 3 Peri/Day 3 Extra
0.691
6.7124E−03

330
34791_at
Day 3 Peri/Day 3 Extra
0.640
3.7040E−03

331
38242_at
Day 3 Peri/Day 3 Extra
0.640
7.2677E−04

336
32173_at
Day 7 Peri/Day 7 Extra
0.645
6.3967E−03

338
35907_at
Day 3 Peri/Day 3 Extra
0.646
8.5538E−03

340
32440_at
Day 3 Peri/Day 3 Extra
0.647
6.1617E−03

341
40587_s_at
Day 3 Peri/Day 3 Extra
0.718
6.3530E−03

342
39219_at
Day 7 Peri/Day 7 Extra
0.647
8.7653E−03

344
35298_at
Day 3 Peri/Day 3 Extra
0.649
2.0180E−03

345
35983_at
Day 3 Peri/Day 3 Extra
0.651
3.7380E−03

346
31527_at
Day 3 Peri/Day 3 Extra
0.651
6.9801E−03

347
41551_at
Day 7 Peri/Day 7 Extra
0.651
8.1132E−03

349
33117_r_at
Day 3 Peri/Day 3 Extra
0.652
2.4740E−03

353
291_s_at
Day 3 Peri/Day 3 Extra
0.655
8.7414E−03

354
31680_at
Day 7 Peri/Day 7 Extra
0.654
8.0454E−03

355
38369_at
Day 7 Peri/Day 7 Extra
0.654
5.5186E−03

357
41223_at
Day 3 Peri/Day 3 Extra
0.656
7.0969E−03

358
34401_at
Day 3 Peri/Day 3 Extra
0.656
5.8159E−03

362
956_at
Day 7 Peri/Day 7 Extra
0.658
8.0238E−03

364
38702_at
Day 3 Peri/Day 3 Extra
0.660
3.6355E−03

368
35351_at
Day 3 Peri/Day 3 Extra
0.662
1.3875E−03

369
41037_at
Day 7 Peri/Day 7 Extra
0.662
6.4186E−04

370
1009_at
Day 3 Peri/Day 3 Extra
0.662
6.3134E−03

372
41040_at
Day 7 Peri/Day 7 Extra
0.663
2.3436E−03

373
39418_at
Day 7 Peri/Day 7 Extra
0.664
2.4392E−03

39418_at
Day 3 Peri/Day 3 Extra
0.730
4.3297E−03

374
31722_at
Day 3 Peri/Day 3 Extra
0.665
8.4932E−03

381
39767_at
Day 3 Peri/Day 3 Extra
0.669
4.6792E−03

385
36169_at
Day 3 Peri/Day 3 Extra
0.706
1.3204E−03

388
32536_at
Day 3 Peri/Day 3 Extra
0.672
3.7237E−03

396
37305_at
Day 7 Peri/ Day 7 Extra
0.677
5.6094E−03

37305_at
Day 3 Peri/Day 3 Extra
0.701
9.0063E−03

398
33396_at
Day 3 Peri/Day 3 Extra
0.679
6.0265E−03

33396_at
Day 7 Peri/Day 7 Extra
0.695
5.1049E−03

401
31708_at
Day 3 Peri/Day 3 Extra
0.682
4.7648E−03

402
38076_at
Day 3 Peri/Day 3 Extra
0.682
3.2512E−04

403
37936_at
Day 3 Peri/Day 3 Extra
0.682
1.2100E−03

404
40778_at
Day 3 Peri/Day 3 Extra
0.687
5.4834E−03

405
37295_at
Day 7 Peri/Day 7 Extra
0.683
5.1041E−03

406
36135_at
Day 3 Peri/Day 3 Extra
0.683
7.3375E−03

412
35309_at
Day 3 Peri/Day 3 Extra
0.685
2.8284E−03

420
35751_at
Day 3 Peri/Day 3 Extra
0.689
9.9046E−03

421
40745_at
Day 3 Peri/Day 3 Extra
0.689
1.6623E−03

423
37739_at
Day 3 Peri/Day 3 Extra
0.690
4.8988E−03

425
41408_at
Day 3 Peri/Day 3 Extra
0.691
6.4202E−03

426
34315_at
Day 3 Peri/Day 3 Extra
0.692
3.6562E−04

432
32437_at
Day 3 Peri/Day 3 Extra
0.693
1.4564E−03

437
2025_s_at
Day 3 Peri/Day 3 Extra
0.746
9.3963E−03

441
38485_at
Day 3 Peri/Day 3 Extra
0.696
2.0589E−03

442
34835_at
Day 3 Peri/Day 3 Extra
0.696
1.6857E−03

446
529_at
Day 7 Peri/Day 7 Extra
0.697
3.7478E−03

455
37294_at
Day 3 Peri/Day 3 Extra
0.704
5.5679E−03

459
37704_at
Day 3 Peri/Day 3 Extra
0.720
1.7216E−03

462
39814_s_at
Day 3 Peri/Day 3 Extra
0.708
6.9810E−03

465
34679_at
Day 3 Peri/Day 3 Extra
0.709
4.4827E−03

466
1030_s_at
Day 7 Peri/Day 7 Extra
0.711
1.5853E−03

467
39921_at
Day 3 Peri/Day 3 Extra
0.711
8.1965E−03

469
37311_at
Day 3 Peri/Day 3 Extra
0.713
2.9353E−04

471
36187_at
Day 3 Peri/Day 3 Extra
0.715
1.3879E−03

484
467_at
Day 7 Peri/Day 7 Extra
0.725
7.2710E−03

485
41760_at
Day 3 Peri/Day 3 Extra
0.726
1.4279E−03

486
36624_at
Day 3 Peri/Day 3 Extra
0.726
5.8955E−03

491
39758_f_at
Day 3 Peri/Day 3 Extra
0.732
1.6743E−03

492
41224_at
Day 3 Peri/Day 3 Extra
0.732
7.2017E−03

495
33942_s_at
Day 3 Peri/ Day 3 Extra
0.734
2.7323E−03

496
32644_at
Day 3 Peri/Day 3 Extra
0.735
1.7224E−03

498
38592_s_at
Day 3 Peri/Day 3 Extra
0.736
1.6693E−03

499
34380_at
Day 3 Peri/Day 3 Extra
0.736
6.0626E−03

502
40111_g_at
Day 3 Peri/Day 3 Extra
0.737
9.0628E−03

512
39027_at
Day 3 Peri/Day 3 Extra
0.746
6.3689E−03

514
36952_at
Day 3 Peri/Day 3 Extra
0.750
6.1291E−03

516
39741_at
Day 3 Peri/Day 3 Extra
0.752
2.0159E−03

517
41221_at
Day 3 Peri/Day 3 Extra
0.752
1.6814E−03

523
32589_at
Day 7 Peri/Day 7 Extra
0.756
2.8970E−03

534
35631_at
Day 3 Peri/Day 3 Extra
0.764
7.2269E−03

536
37610_at
Day 3 Peri/Day 3 Extra
0.764
2.5200E−03

544
32324_at
Day 3 Peri/Day 3 Extra
0.769
5.4500E−03

546
39058_at
Day 3 Peri/Day 3 Extra
0.796
8.8684E−03

553
32757_at
Day 3 Peri/Day 3 Extra
0.778
1.2850E−03

571
41231_f_at
Day 3 Peri/Day 3 Extra
0.796
7.6383E−04

585
1235_at
Day 3 Peri/Day 3 Extra
0.824
9.9973E−03

TABLE 9

Diagnostic Down

Public

Gene ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Fold Change
P value

178
5268
Entrez Gene
serpin peptidase inhibitor,
862_at
Day 3 Peri/Day 3 Extra
0.548
8.5245E−03

clade B (ovalbumin), member 5
862_at
Day 7 Peri/Day 7 Extra
0.576
5.9941E−03

220
7295
Entrez Gene
thioredoxin
36992_at
Day 3 Peri/Day 3 Extra
0.583
3.0827E−03

TABLE 10

Diagnostic Down

Public

Gene ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Fold Change
P value

110
1525
Entrez Gene
coxsackie virus and
37534_at
Day 3 Peri/Day 3 Extra
0.493
7.3178E−03

adenovirus receptor

229
8581
Entrez Gene
lymphocyte antigen 6
36284_at
Day 7 Peri/Day 7 Extra
0.589
9.2936E−03

complex, locus D

TABLE 11

Diagnostic Down

Public

Gene ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Fold Change
P value

250
4775
Entrez Gene
nuclear factor of activated T-cells,
40823_s_at
Day 3 Peri/Day 3 Extra
0.633
7.3198E−03

cytoplasmic, calcineurin-dependent 3

252
4790
Entrez Gene
nuclear factor of kappa light polypeptide
1378_g_at
Day 3 Peri/Day 3 Extra
0.598
6.5881E−03

gene enhancer in B-cells 1 (p105)

355
4615
Entrez Gene
myeloid differentiation primary
38369_at
Day 7 Peri/Day 7 Extra
0.654
5.5186E−03

response gene (88)

TABLE 12

Diagnostic Down

Public

Gene ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Fold Change
P value

202
10553
Entrez Gene
HIV-1 Tat interactive protein 2,
38824_at
Day 3 Peri/Day 3 Extra
0.592
5.7073E−03

30 kDa

TABLE 13

Diagnostic Down

Gene
Public

Fold

ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Change
P value

8
9415
Entrez Gene
fatty acid desaturase 2
32190_at
Day 3 Peri/Day 0 Peri
0.365
8.5757E−03

11
553168
Entrez Gene
chromosome 1 open reading frame 68
31326_at
Day 7 Peri/Day 0 Peri
0.229
1.6500E−05

31326_at
Day 3 Peri/Day 0 Peri
0.487
3.0725E−03

18
7123
Entrez Gene
C-type lectin domain family 3, member B
36569_at
Day 3 Peri/Day 0 Peri
0.356
1.8400E−05

36569_at
Day 7 Peri/Day 0 Peri
0.428
5.8746E−04

20
AB011538
GenBank
CDNA clone IMAGE: 5922621
35324_at
Day 3 Peri/Day 0 Peri
0.447
1.3446E−04

35324_at
Day 7 Peri/Day 0 Peri
0.623
4.2479E−03

24
2053
Entrez Gene
epoxide hydrolase 2, cytoplasmic
41473_at
Day 3 Peri/Day 0 Peri
0.521
6.6949E−03

31
8483
Entrez Gene
cartilage intermediate layer protein, nucleotide
34985_at
Day 3 Peri/Day 0 Peri
0.354
4.8214E−04

pyrophosphohydrolase
34985_at
Day 7 Peri/Day 0 Peri
0.381
2.9109E−03

34
10458
Entrez Gene
BAI1-associated protein 2
37761_at
Day 7 Peri/Day 0 Peri
0.358
3.2292E−04

36
2273
Entrez Gene
four and a half LIM domains 1
32542_at
Day 3 Peri/Day 0 Peri
0.598
1.0604E−03

32542_at
Day 7 Peri/Day 0 Peri
0.643
1.4304E−03

44
2194
Entrez Gene
fatty acid synthase
38429_at
Day 3 Peri/Day 0 Peri
0.512
8.4627E−03

51
5354
Entrez Gene
proteolipid protein 1 (Pelizaeus-Merzbacher
41158_at
Day 3 Peri/Day 0 Peri
0.715
7.5707E−03

disease, spastic paraplegia 2, uncomplicated)

56
1675
Entrez Gene
D component of complement (adipsin)
40282_s_at
Day 7 Peri/Day 0 Peri
0.410
3.2238E−03

57
23242
Entrez Gene
cordon-bleu homolog (mouse)
35669_at
Day 7 Peri/Day 0 Peri
0.543
1.1342E−03

35669_at
Day 3 Peri/Day 0 Peri
0.585
1.2820E−03

71
HG3570-
The Institute for
—
936_s_at
Day 7 Peri/Day 0 Peri
0.679
6.6192E−03

HT377
Genomic Research

77
9524
Entrez Gene
glycoprotein, synaptic 2
38966_at
Day 7 Peri/Day 0 Peri
0.614
2.1060E−03

93
1152
Entrez Gene
creatine kinase, brain
40863_r_at
Day 7 Peri/Day 0 Peri
0.507
3.2271E−04

94
10450
Entrez Gene
peptidylprolyl isomerase E (cyclophilin E)
34365_at
Day 7 Peri/Day 0 Peri
0.638
2.8273E−03

101
8532
Entrez Gene
carboxypeptidase Z
37248_at
Day 7 Peri/Day 0 Peri
0.483
2.2125E−04

37248_at
Day 3 Peri/Day 0 Peri
0.522
7.1260E−04

102
6038
Entrez Gene
ribonuclease, RNase A family, 4
32664_at
Day 3 Peri/Day 0 Peri
0.636
5.8524E−04

32664_at
Day 7 Peri/Day 0 Peri
0.691
3.6796E−03

107
4163
Entrez Gene
mutated in colorectal cancers
35561_at
Day 7 Peri/Day 0 Peri
0.606
7.2171E−03

113
6490
Entrez Gene
silver homolog (mouse)
38327_at
Day 3 Peri/Day 0 Peri
0.710
9.2062E−03

130
U18300
GenBank
damage-specific DNA binding protein 2,
1243_at
Day 7 Peri/Day 0 Peri
0.749
8.6022E−03

48 kDa /// LIM homeobox 3

131
23051
Entrez Gene
zinc fingers and homeoboxes 3
40461_at
Day 3 Peri/Day 0 Peri
0.738
3.2244E−03

136
2013
Entrez Gene
epithelial membrane protein 2
39631_at
Day 7 Peri/Day 0 Peri
0.629
5.1967E−04

137
81563
Entrez Gene
chromosome 1 open reading frame 21
41679_at
Day 7 Peri/Day 0 Peri
0.517
1.2344E−03

41679_at
Day 3 Peri/Day 0 Peri
0.607
8.6951E−03

138
1638
Entrez Gene
dopachrome tautornerase (dopachrome delta-
41182_at
Day 7 Peri/Day 0 Peri
0.518
2.7300E−05

isomerase, tyrosine-related protein 2)
41182_at
Day 3 Peri/Day 0 Peri
0.596
1.9071E−04

148
4713
Entrez Gene
NADH dehydrogenase (ubiquinone) 1 beta
35773_i_at
Day 7 Peri/Day 0 Peri
0.748
5.4735E−03

subcomplex, 7, 18 kDa
35774_r_at
Day 7 Peri/Day 3 Peri
0.791
1.2691E−03

149
1396
Entrez Gene
cysteine-rich protein 1 (intestinal)
33232_at
Day 7 Peri/Day 0 Peri
0.526
3.2907E−04

33232_at
Day 3 Peri/Day 0 Peri
0.596
1.5417E−03

151
55187
Entrez Gene
vacuolar protein sorting 13D (yeast)
32743_at
Day 3 Peri/Day 0 Peri
0.772
6.0079E−03

160
113146
Entrez Gene
chromosome 14 open reading frame 78
36497_at
Day 7 Peri/Day 0 Peri
0.545
2.9700E−05

36497_at
Day 3 Peri/Day 0 Peri
0.577
3.7100E−05

179
1474
Entrez Gene
cystatin E/M
33128_s_at
Day 7 Peri/Day 0 Peri
0.549
1.9072E−03

33128_s_at
Day 3 Peri/Day 0 Peri
0.605
2.6588E−03

185
4736
Entrez Gene
ribosomal protein L10a
36786_at
Day 7 Peri/Day 0 Peri
0.783
1.0376E−03

209
217
Entrez Gene
aldehyde dehydrogenase 2 family
32747_at
Day 7 Peri/Day 0 Peri
0.741
2.4111E−03

(mitochondrial)

212
8623
Entrez Gene
acetylserotonin O-methyltransferase-like
36553_at
Day 3 Peri/Day 0 Peri
0.710
1.0994E−04

213
169611
Entrez Gene
olfactomedin-like 2A
38312_at
Day 3 Peri/Day 0 Peri
0.719
4.2489E−04

223
2621
Entrez Gene
growth arrest-specific 6
1597_at
Day 3 Peri/Day 0 Peri
0.689
5.8701E−03

230
AB006780
GenBank
lectin, galactoside-binding, soluble, 3
35367_at
Day 7 Peri/Day 0 Peri
0.683
4.0159E−04

(galectin 3) /// galectin-3 internal gene
35367_at
Day 3 Peri/Day 0 Peri
0.763
8.3297E−03

231
6929
Entrez Gene
transcription factor 3 (E2A immunoglobulin
1373_at
Day 3 Peri/Day 0 Peri
0.738
3.1310E−04

enhancer binding factors E12/E47)

240
26040
Entrez Gene
SET binding protein 1
34990_at
Day 3 Peri/Day 0 Peri
0.593
3.4533E−04

34990_at
Day 7 Peri/Day 0 Peri
0.711
9.8766E−03

257
AI557912
GenBank
translocase of outer mitochondrial membrane 7
39025_at
Day 7 Peri/Day 0 Peri
0.798
1.0424E−03

homolog (yeast) /// hypothetical protein

LOC201725

260
5453
Entrez Gene
POU domain, class 3, transcription factor 1
33675_at
Day 3 Peri/Day 0 Peri
0.606
4.5158E−03

273
23090
Entrez Gene
zinc finger protein 423
34950_at
Day 3 Peri/Day 0 Peri
0.613
2.6182E−04

276
56967
Entrez Gene
chromosome 14 open reading frame 132
41837_at
Day 3 Peri/Day 0 Peri
0.614
6.2326E−04

41837_at
Day 7 Peri/Day 0 Peri
0.660
1.7553E−03

277
8560
Entrez Gene
degenerative spermatocyte homolog 1, lipid
33337_at
Day 7 Peri/Day 0 Peri
0.690
1.2271E−03

desaturase (Drosophila)

280
8663
Entrez Gene
eukaryotic translation initiation factor 3,
34841_at
Day 3 Peri/Day 0 Peri
0.776
9.4126E−03

subunit 8, 110 kDa

285
23650
Entrez Gene
tripartite motif-containing 29
1898_at
Day 7 Peri/Day 0 Peri
0.617
3.0138E−03

300
22883
Entrez Gene
calsyntenin 1
41498_at
Day 3 Peri/Day 0 Peri
0.777
3.9252E−03

304
3290
Entrez Gene
hydroxysteroid (11-beta) dehydrogenase 1
35702_at
Day 7 Peri/Day 0 Peri
0.628
6.5442E−03

306
2065
Entrez Gene
v-erb-b2 erythroblastic leukemia viral oncogene
32787_at
Day 7 Peri/Day 0 Peri
0.677
7.5081E−03

homolog 3 (avian)

307
10217
Entrez Gene
CTD (carboxy-terminal domain, RNA
40196_at
Day 7 Peri/Day 0 Peri
0.735
2.0122E−03

polymerase II, polypeptide A) small
40196_at
Day 3 Peri/Day 0 Peri
0.770
5.2302E−03

phosphatase-like

311
4681
Entrez Gene
neuroblastoma, suppression of tumorigenicity 1
37005_at
Day 7 Peri/Day 0 Peri
0.642
1.7449E−03

37005_at
Day 3 Peri/Day 0 Peri
0.695
2.4042E−03

323
9296
Entrez Gene
ATPase, H+ transporting, lysosomal 14 kDa,
37395_at
Day 7 Peri/Day 0 Peri
0.840
4.0330E−03

V1 subunit F

328
6141
Entrez Gene
ribosomal protein L18
31546_at
Day 7 Peri/Day 0 Peri
0.760
9.8180E−03

333
2709
Entrez Gene
gap junction protein, beta 5 (connexin 31.1)
38903_at
Day 7 Peri/Day 0 Peri
0.643
1.7967E−03

339
HG162-
The Institute for
—
1278_at
Day 3 Peri/Day 0 Peri
0.647
6.0118E−03

HT3165
Genomic Research

374
6122
Entrez Gene
ribosomal protein L3
31722_at
Day 7 Peri/Day 0 Peri
0.792
9.5624E−03

375
6176
Entrez Gene
ribosomal protein, large, P1
31957_r_at
Day 7 Peri/Day 0 Peri
0.666
3.7416E−03

378
10014
Entrez Gene
histone deacetylase 5
38810_at
Day 7 Peri/Day 0 Peri
0.778
7.8739E−03

38810_at
Day 3 Peri/Day 0 Peri
0.784
9.3572E−04

379
10610
Entrez Gene
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-
34693_at
Day 7 Peri/Day 0 Peri
0.668
5.8340E−04

galactosyl-1,3)-N-acetylgalactosaminide

alpha-2,6-sialyltransferase 2

383
4856
Entrez Gene
nephroblastoma overexpressed gene
39250_at
Day 3 Peri/Day 0 Peri
0.670
5.1134E−03

384
9314
Entrez Gene
Kruppel-like factor 4 (gut)
36214_at
Day 7 Peri/Day 0 Peri
0.670
7.5246E−03

386
10904
Entrez Gene
bladder cancer associated protein
35266_at
Day 3 Peri/Day 0 Peri
0.815
4.1112E−03

404
3028
Entrez Gene
hydroxyacyl-Coenzyme A dehydrogenase,
40778_at
Day 7 Peri/Day 0 Peri
0.785
3.6406E−03

type II

408
4610
Entrez Gene
v-myc myelocytomatosis viral oncogene
1490_at
Day 3 Peri/Day 0 Peri
0.684
2.9494E−04

homolog 1, lung carcinoma derived (avian)

416
10420
Entrez Gene
testis-specific kinase 2
33164_at
Day 7 Peri/Day 0 Peri
0.688
8.0384E−03

424
4134
Entrez Gene
microtubule-associated protein 4
33850_at
Day 3 Peri/Day 0 Peri
0.690
9.2919E−04

33850_at
Day 7 Peri/Day 0 Peri
0.747
8.7450E−03

429
10570
Entrez Gene
dihydropyrimidinase-like 4
39503_s_at
Day 7 Peri/Day 0 Peri
0.693
9.8616E−03

432
6193
Entrez Gene
ribosomal protein S5
32437_at
Day 7 Peri/Day 0 Peri
0.740
3.6964E−03

32437_at
Day 3 Peri/Day 0 Peri
0.808
6.6422E−03

433
23492
Entrez Gene
chromobox homolog 7
36894_at
Day 3 Peri/Day 0 Peri
0.742
1.6692E−03

36894_at
Day 7 Peri/Day 0 Peri
0.742
3.4050E−03

434
4809
Entrez Gene
NHP2 non-histone chromosome protein
41746_at
Day 3 Peri/Day 0 Peri
0.830
6.1703E−03

2-like 1 (S. cerevisiae)

436
79090
Entrez Gene
trafficking protein particle complex 6A
36529_at
Day 3 Peri/Day 0 Peri
0.694
6.8032E−03

438
84525
Entrez Gene
homeodomain-only protein
39698_at
Day 7 Peri/Day 0 Peri
0.695
8.7289E−03

449
57017
Entrez Gene
chromosome 16 open reading frame 49
34810_at
Day 7 Peri/Day 0 Peri
0.810
4.2261E−03

457
4174
Entrez Gene
MCM5 minichromosome maintenance deficient
982_at
Day 7 Peri/Day 3 Peri
0.706
4.9235E−04

5, cell division cycle 46 (S. cerevisiae)

458
10278
Entrez Gene
embryonal Fyn-associated substrate
33883_at
Day 7 Peri/Day 0 Peri
0.706
2.0000E−05

33883_at
Day 3 Peri/Day 0 Peri
0.718
6.1275E−04

460
4357
Entrez Gene
mercaptopyruvate sulfurtransferase
36124_at
Day 7 Peri/Day 0 Peri
0.707
7.1338E−04

461
3727
Entrez Gene
jun D proto-oncogene
41483_s_at
Day 7 Day 0 Peri
0.707
9.7391E−03

464
22882
Entrez Gene
zinc fingers and homeoboxes 2
41503_at
Day 3 Peri/Day 0 Peri
0.709
9.7700E−05

41503_at
Day 7 Peri/Day 0 Peri
0.830
5.9812E−03

472
2064
Entrez Gene
v-erb-b2 erythroblastic leukemia viral oncogene
33218_at
Day 3 Peri/Day 0 Peri
0.718
4.9044E−04

homolog 2, neuro/glioblastoma derived
33218_at
Day 7 Peri/Day 0 Peri
0.740
6.2999E−04

oncogene homolog (avian)

474
79026
Entrez Gene
AHNAK nucleoprotein (desmoyokin)
37027_at
Day 7 Peri/Day 0 Peri
0.748
8.8700E−05

37027_at
Day 3 Peri/Day 0 Peri
0.780
3.1374E−04

476
949
Entrez Gene
scavenger receptor class B, member 1
41200_at
Day 7 Peri/Day 0 Peri
0.720
1.3768E−03

41200_at
Day 3 Peri/Day 0 Peri
0.721
1.6250E−03

477
1917
Entrez Gene
eukaryotic translation elongation factor 1
35174_i_at
Day 7 Peri/Day 0 Peri
0.720
6.7372E−04

alpha 2

478
6205
Entrez Gene
ribosomal protein S11
32330_at
Day 7 Peri/Day 0 Peri
0.721
3.3215E−03

481
79095
Entrez Gene
chromosome 9 open reading frame 16
41047_at
Day 3 Peri/Day 0 Peri
0.725
5.9374E−03

483
22924
Entrez Gene
microtubule-associated protein, RP/EB family,
40825_at
Day 7 Peri/Day 0 Peri
0.725
1.1882E−03

member 3
40825_at
Day 3 Peri/Day 0 Peri
0.765
2.4008E−03

486
3615
Entrez Gene
IMP (inosine monophosphate) dehydrogenase 2
36624_at
Day 7 Peri/Day 0 Peri
0.740
8.1540E−04

487
1981
Entrez Gene
eukaryotic translation initiation factor 4
32844_at
Day 7 Peri/Day 0 Peri
0.727
9.4700E−03

gamma, 1

494
10075
Entrez Gene
HECT, UBA and WWE domain containing 1
34372_at
Day 3 Peri/Day 0 Peri
0.802
9.1907E−03

497
HG2238-
The Institute for
—
329_s_at
Day 3 Peri/Day 0 Peri
0.736
9.9413E−03

HT232
Genomic Research

501
10634
Entrez Gene
growth arrest-specific 2 like 1
31874_at
Day 7 Peri/Day 0 Peri
0.737
7.5700E−05

31874_at
Day 3 Peri/Day 0 Peri
0.791
1.9327E−03

503
10424
Entrez Gene
progesterone receptor membrane component 2
38821_at
Day 7 Peri/Day 0 Peri
0.738
3.9496E−03

38821_at
Day 3 Peri/Day 0 Peri
0.746
7.1002E−03

504
8531
Entrez Gene
cold shock domain protein A
39839_at
Day 7 Peri/Day 0 Peri
0.738
8.5534E−03

505
5439
Entrez Gene
polymerase (RNA) II (DNA directed)
1486_at
Day 7 Peri/Day 0 Peri
0.740
2.7928E−03

polypeptide J, 13.3 kDa
1486_at
Day 7 Peri/Day 3 Peri
0.772
1.7983E−03

507
6227
Entrez Gene
ribosomal protein S21
32744_at
Day 7 Peri/Day 0 Peri
0.740
7.2902E−03

508
6169
Entrez Gene
ribosomal protein L38
34085_at
Day 7 Peri/Day 0 Peri
0.743
6.3557E−03

510
6218
Entrez Gene
ribosomal protein S17
34592_at
Day 7 Peri/Day 0 Peri
0.745
2.8146E−03

518
10638
Entrez Gene
S-phase response (cyclin-related)
1685_at
Day 3 Peri/Day 0 Peri
0.754
1.2093E−03

522
162427
Entrez Gene
hypothetical protein LOC162427
38423_at
Day 3 Peri/Day 0 Peri
0.845
2.2722E−03

38423_at
Day 7 Peri/Day 0 Peri
0.848
1.7317E−03

524
6202
Entrez Gene
ribosomal protein S8
31583_at
Day 7 Peri/Day 0 Peri
0.756
8.6210E−03

528
26003
Entrez Gene
golgi reassembly stacking protein 2, 55 kDa
35805_at
Day 3 Peri/Day 0 Peri
0.761
2.3291E−04

35805_at
Day 7 Peri/Day 0 Peri
0.770
2.6315E−03

530
4601
Entrez Gene
MAX interactor 1
654_at
Day 7 Peri/Day 0 Peri
0.783
5.2959E−03

39072_at
Day 3 Peri/Day 0 Peri
0.839
6.8595E−03

531
6293
Entrez Gene
vacuolar protein sorting 52 (yeast)
32658_at
Day 7 Peri/Day 0 Peri
0.858
6.8088E−03

533
10067
Entrez Gene
secretory carrier membrane protein 3
32799_at
Day 7 Peri/Day 0 Peri
0.763
8.9346E−03

535
6203
Entrez Gene
ribosomal protein S9
31511_at
Day 7 Peri/Day 0 Peri
0.764
7.8708E−03

538
5036
Entrez Gene
proliferation-associated 2G4, 38 kDa
41600_at
Day 7 Peri/Day 0 Peri
0.765
6.9426E−03

539
9249
Entrez Gene
dehydrogenase/reductase (SDR family)
40782_at
Day 3 Peri/Day 0 Peri
0.765
6.4510E−03

member 3

540
1337
Entrez Gene
cytochrome c oxidase subunit VIa
41206_r_at
Day 7 Peri/Day 0 Peri
0.765
1.7769E−03

polypeptide 1

543
203069
Entrez Gene
R3H domain and coiled-coil containing 1
35156_at
Day 7 Peri/Day 0 Peri
0.769
8.4083E−03

545
23294
Entrez Gene
ankyrin repeat and sterile alpha motif domain
40971_at
Day 3 Peri/Day 0 Peri
0.796
3.4853E−03

containing 1

547
1937
Entrez Gene
eukaryotic translation elongation factor 1
1676_s_at
Day 7 Peri/Day 0 Peri
0.771
8.5875E−03

gamma

549
147179
Entrez Gene
WIRE protein
40787_at
Day 3 Peri/Day 0 Peri
0.772
8.6910E−04

558
3163
Entrez Gene
heme oxygenase (decycling) 2
37916_at
Day 7 Peri/Day 3 Peri
0.781
9.4119E−03

559
22864
Entrez Gene
KIAA1002 protein
41366_at
Day 3 Peri/Day 0 Peri
0 781
8.7647E−03

562
9903
Entrez Gene
kelch-like 21 (Drosophila)
37230_at
Day 3 Peri/Day 0 Peri
0.786
5.6275E−03

37230_at
Day 7 Peri/Day 0 Peri
0.812
4.4808E−03

563
5236
Entrez Gene
phosphoglucomutase 1
32210_at
Day 3 Peri/Day 0 Peri
0.789
7.7233E−03

565
2975
Entrez Gene
general transcription factor IIIC, polypeptide 1,
35671_at
Day 7 Peri/Day 0 Peri
0.791
3.1660E−03

alpha 220 kDa

566
10956
Entrez Gene
amplified in osteosarcoma
36996_at
Day 7 Peri/Day 0 Peri
0.791
9.0785E−03

36996_at
Day 3 Peri/Day 0 Peri
0.818
6.2854E−03

569
527
Entrez Gene
ATPase, H+ transporting, lysosomal 16 kDa,
36994_at
Day 7 Peri/Day 0 Peri
0.794
8.6116E−03

V0 subunit c

570
8720
Entrez Gene
membrane-bound transcription factor peptidase,
36964_at
Day 3 Peri/Day 0 Peri
0.795
9.8019E−03

site 1

572
286440
Entrez Gene
hypothetical protein LOC286440
41655_at
Day 3 Peri/Day 0 Peri
0.796
8.4134E−03

573
6136
Entrez Gene
ribosomal protein L12
33668_at
Day 7 Peri/Day 0 Peri
0.797
2.3409E−03

575
445
Entrez Gene
argininosuccinate synthetase
40541_at
Day 7 Peri/Day 3 Peri
0.799
7.5623E−03

576
11224
Entrez Gene
ribosomal protein L35
41765_at
Day 7 Peri/Day 0 Peri
0.800
6.9298E−03

578
4779
Entrez Gene
nuclear factor (erythroid-derived 2)-like 1
38439_at
Day 7 Peri/Day 0 Peri
0.811
5.5209E−03

579
149603
Entrez Gene
ring finger protein 187
39722_at
Day 3 Peri/Day 0 Peri
0.812
7.5346E−03

580
8818
Entrez Gene
dolichyl-phosphate mannosyltransferase
38726_at
Day 7 Peri/Day 3 Peri
0.814
3.7920E−03

polypeptide 2, regulatory subunit

581
823
Entrez Gene
calpain 1, (mu/l) large subunit
33908_at
Day 7 Peri/Day 3 Peri
0.815
9.2186E−03

583
6720
Entrez Gene
sterol regulatory element binding transcription
32135_at
Day 3 Peri/Day 0 Peri
0.819
6.4366E−03

factor 1

584
23633
Entrez Gene
Karyopherin alpha 6 (importin alpha 7)
40275_at
Day 3 Peri/Day 0 Peri
0.824
1.6981E−03

40275_at
Day 7 Peri/Day 0 Peri
0.847
5.5244E−03

586
23481
Entrez Gene
pescadillo homolog 1, containing BRCT
41869_at
Day 7 Peri/Day 0 Peri
0.831
9.3885E−03

domain (zebrafish)

TABLE 14

Diagnostic Down

Public

Gene_ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Fold Change
P value

300
22883
Entrez Gene
calsyntenin 1
41498_at
Day 3 Peri/Day 0 Peri
0.777
3.9252E−03

458
10278
Entrez Gene
embryonal Fyn-associated substrate
33883_at
Day 7 Peri/Day 0 Peri
0.706
2.0000E−05

33883_at
Day 3 Peri/Day 0 Peri
0.718
6.1275E−04

476
949
Entrez Gene
scavenger receptor class B,
41200_at
Day 7 Peri/Day 0 Peri
0.720
1.3768E−03

member 1
41200_at
Day 3 Peri/Day 0 Peri
0.721
1.6250E−03

TABLE 15

Diagnostic Down

Public

Fold

Gene ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Change
P value

24
2053
Entrez Gene
epoxide hydrolase 2, cytoplasmic
41473_at
Day 3 Peri/Day 0 Peri
0.521
6.6949E−03

378
10014
Entrez Gene
histone deacetylase 5
38810_at
Day 7 Peri/Day 0 Peri
0.778
7.8739E−03

38810_at
Day 3 Peri/Day 0 Peri
0.784
9.3572E−04

578
4779
Entrez Gene
nuclear factor (erythroid-
38439_at
Day 7 Peri/Day 0 Peri
0.811
5.5209E−03

derived 2)-like 1

TABLE 16

Diagnostic Down

Public

Gene ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Fold Change
P value

102
6038
Entrez Gene
ribonuclease, RNase A family, 4
32664_at
Day 3 Peri/Day 0 Peri
0.636
5.8524E−04

32664_at
Day 7 Peri/Day 0 Peri
0.691
3.6796E−03

TABLE 17

Diagnostic Down

Gene
Public

Fold

ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Change
P value

13
125
Entrez Gene
alcohol dehydrogenase IB (class I), beta polypeptide
35730_at
Day 0 Peri/Day 0 Intra
0.252
5.3255E−03

21
3131
Entrez Gene
Hepatic leukemia factor
38627_at
Day 0 Peri/Day 0 Intra
0.556
5.7849E−03

53
10443
Entrez Gene
Hypothetical gene CG012
1532_g_at
Day 0 Peri/Day 0 Intra
0.660
5.2680E−03

66
51601
Entrez Gene
lipoyltransferase 1
37441_at
Day 0 Peri/Day 0 Intra
0.432
3.4529E−03

90
6924
Entrez Gene
Transcription elongation factor B (SIII), polypeptide 3
32049_f_at
Day 0 Peri/Day 0 Intra
0.469
3.1906E−03

(110 kDa, elongin A)

121
1158
Entrez Gene
creatine kinase, muscle
32486_at
Day 0 Peri/Day 0 Intra
0.501
6.1425E−03

146
4968
Entrez Gene
8-oxoguanine DNA glycosylase
38335_at
Day 0 Peri/Day 0 Intra
0.759
8.2179E−03

157
26610
Entrez Gene
elongation protein 4 homolog (S. cerevisiae)
38347_at
Day 0 Peri/Day 0 Intra
0.533
6.3391E−03

186
644
Entrez Gene
biliverdin reductase A
32618_at
Day 3 Peri/Day 3 Intra
0.702
5.1159E−03

193
23107
Entrez Gene
mitochondrial ribosomal protein S27
39377_at
Day 3 Peri/Day 3 Intra
0.634
9.8004E−03

197
6477
Entrez Gene
Seven in absentia homolog 1 (Drosophila)
32161_at
Day 0 Peri/Day 0 Intra
0.565
2.6625E−03

215
9936
Entrez Gene
CD302 antigen
34760_at
Day 0 Peri/Day 0 Intra
0.580
5.4949E−04

218
128
Entrez Gene
alcohol dehydrogenase 5 (class III), chl polypeptide
37708_r_at
Day 0 Peri/Day 0 Intra
0.600
6.4350E−03

220
7295
Entrez Gene
thioredoxin
36992_at
Day 3 Peri/Day 3 Intra
0.673
4.8045E−03

224
831
Entrez Gene
calpastatin
41257_at
Day 0 Peri/Day 0 Intra
0.700
3.4819E−03

250
4775
Entrez Gene
nuclear factor of activated T-cells, cytoplasmic,
40822_at
Day 0 Peri/Day 0 Intra
0.746
7.0070E−03

calcineurin-dependent 3

254
26135
Entrez Gene
SERPINE1 mRNA binding protein 1
40440_at
Day 3 Peri/Day 3 Intra
0.727
9.5681E−03

262
353
Entrez Gene
adenine phosphoribosyltransferase
34310_at
Day 3 Peri/Day 3 Intra
0.619
3.4883E−03

267
54665
Entrez Gene
round spermatid basic protein 1
37828_at
Day 0 Peri/Day 0 Intra
0.626
4.8045E−03

282
23392
Entrez Gene
KIAA0368
34414_at
Day 0 Peri/Day 0 Intra
0.644
5.3735E−03

290
25797
Entrez Gene
glutaminyl-peptide cyclotransferase (glutaminyl
35966_at
Day 0 Peri/Day 0 Intra
0.663
6.8919E−03

cyclase)

291
5092
Entrez Gene
6-pyruvoyl-tetrahydropterin synthase/dimerization
34352_at
Day 3 Peri/Day 3 Intra
0.704
1.5982E−03

cofactor of hepatocyte nuclear factor 1 alpha (TCF1)

298
10289
Entrez Gene
translation factor sui1 homolog
33351_at
Day 0 Peri/Day 0 Intra
0.624
5.2711E−04

316
8824
Entrez Gene
carboxylesterase 2 (intestine, liver)
40882_at
Day 7 Peri/Day 7 Intra
0.635
9.8901E−03

341
9521
Entrez Gene
eukaryotic translation elongation factor 1 epsilon 1
40587_s_at
Day 3 Peri/Day 3 Intra
0.697
4.8656E−04

351
132556
Entrez Gene
similar to Transcription factor BTF3 homolog 3
31519_f_at
Day 0 Peri/Day 0 Intra
0.653
9.2891E−03

366
8192
Entrez Gene
CipP caseinolytic peptidase, ATP-dependent,
32528_at
Day 7 Peri/Day 7 Intra
0.661
7.3475E−03

proteolytic subunit homolog (E. coli)

370
3094
Entrez Gene
histidine triad nucleotide binding protein 1
1009_at
Day 3 Peri/Day 3 Intra
0.704
8.1604E−03

385
4694
Entrez Gene
NADH dehydrogenase (ubiquinone) 1 alpha
36169_at
Day 3 Peri/Day 3 Intra
0.754
3.5482E−03

subcomplex, 1, 7.5 kDa

403
9128
Entrez Gene
PRP4 pre-mRNA processing factor 4 homolog (yeast)
37936_at
Day 3 Peri/Day 3 Intra
0.809
4.3656E−03

410
23075
Entrez Gene
SWAP-70 protein
31869_at
Day 0 Peri/Day 0 Intra
0.684
5.9906E−03

413
6138
Entrez Gene
ribosomal protein L15
32433_at
Day 0 Peri/Day 0 Intra
0.686
4.8021E−03

417
9759
Entrez Gene
histone deacetylase 4
38271_at
Day 0 Peri/Day 0 Intra
0.776
6.2327E−03

418
4676
Entrez Gene
nucleosome assembly protein 1-like 4
32575_at
Day 3 Peri/Day 3 Intra
0.820
9.3028E−03

419
5425
Entrez Gene
polymerase (DNA directed), delta 2, regulatory subunit
1470_at
Day 3 Peri/Day 3 Intra
0.689
5.7659E−03

50 kDa

439
2549
Entrez Gene
GRB2-associated binding protein 1
33997_at
Day 0 Peri/Day 0 Intra
0.731
4.0375E−03

442
23385
Entrez Gene
nicastrin
34835_at
Day 3 Peri/Day 3 Intra
0.790
4.8084E−03

452
539
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F1
37029_at
Day 3 Peri/Day 3 Intra
0.701
5.7342E−03

complex, O subunit (oligomycin sensitivity

conferring protein)

462
51635
Entrez Gene
dehydrogenase/reductase (SDR family) member 7
39814_s_at
Day 3 Peri/Day 3 Intra
0.740
6.8403E−03

470
3184
Entrez Gene
heterogeneous nuclear ribonucleoprotein D (AU-rich
38016_at
Day 0 Peri/Day 0 Intra
0.714
4.2703E−03

element RNA binding protein 1, 37 kDa)

480
HG1614-
The Institute
—
954_s_at
Day 7 Peri/Day 7 Intra
0.747
1.0730E−03

HT161
for

Genomic

Research

488
22934
Entrez Gene
ribose 5-phosphate isomerase A (ribose 5-phosphate
38036_at
Day 0 Peri/Day 0 Intra
0.729
4.9732E−03

epimerase)

490
11311
Entrez Gene
vacuolar protein sorting 45A (yeast)
35779_at
Day 0 Peri/Day 0 Intra
0.731
7.1397E−03

511
9540
Entrez Gene
tumor protein p53 inducible protein 3
36079_at
Day 3 Peri/Day 3 Intra
0.746
5.1335E−03

527
9724
Entrez Gene
UTP14, U3 small nucleolar ribonucleoprotein,
39405_at
Day 0 Peri/Day 0 Intra
0.760
3.9078E−03

homolog C (yeast)

534
5437
Entrez Gene
polymerase (RNA) II (DNA directed) polypeptide H
35631_at
Day 3 Peri/Day 3 Intra
0.772
5.4217E−03

541
23623
Entrez Gene
RUN and SH3 domain containing 1
34264_at
Day 3 Peri/Day 3 Intra
0.768
9.1280E−03

553
8480
Entrez Gene
RAE1 RNA export 1 homolog (S. pombe)
32758_g_at
Day 7 Peri/Day 7 Intra
0.786
2.2519E−03

571
3151
Entrez Gene
high-mobility group nucleosomal binding domain 2
41231_f_at
Day 3 Peri/Day 3 Intra
0.827
4.3201E−03

585
7534
Entrez Gene
tyrosine 3-monooxygenase/tryptophan
1235_at
Day 3 Peri/Day 3 Intra
0.853
7.0175E−03

5-monooxygenase activation protein,

zeta polypeptide

TABLE 18

Diagnostic Down

Public

Gene ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Fold Change
P value

220
7295
Entrez Gene
thioredoxin
36992_at
Day 3 Peri/Day 3 Intra
0.673
4.8045E−03

TABLE 19

Diagnostic Down

Public

Seq_ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Fold Change
P value

250
4775
Entrez Gene
nuclear factor of activated T-cells, cytoplasmic,
40822_at
Day 0 Peri/Day 0 Intra
0.746
7.0070E−03

calcineurin-dependent 3

417
9759
Entrez Gene
histone deacetylase 4
38271_at
Day 0 Peri/Day 0 Intra
0.776
6.2327E−03

490
11311
Entrez Gene
vacuolar protein sorting 45A (yeast)
35779_at
Day 0 Peri/Day 0 Intra
0.731
7.1397E−03

TABLE 20

Diagnostic Down

Gene
Public

Fold

ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Change
P value

1
4250
Entrez Gene
secretoglobin, family 2A, member 2
36329_at
Day 0 Intra/Day 0 Control
0.009
7.1701E−04

36329_at
Day 3 Intra/Day 3 Control
0.017
3.3179E−04

36329_at
Day 7 Intra/Day 7 Control
0.021
2.8985E−03

36329_at
Day 3 Intra/Day 3 Extra
0.023
2.7212E−03

2
5304
Entrez Gene
prolactin-induced protein
41094_at
Day 0 Intra/Day 0 Control
0.032
5.1676E−04

41094_at
Day 7 Intra/Day 7 Control
0.076
9.5561E−03

41094_at
Day 3 Intra/Day 3 Control
0.094
1.9791E−04

3
10647
Entrez Gene
secretoglobin, family 1D, member 2
32880_at
Day 0 Intra/Day 0 Control
0.033
4.4000E−05

32880_at
Day 7 Intra/Day 7 Control
0.065
7.5456E−03

32880_at
Day 3 Intra/Day 3 Control
0.075
8.2511E−04

32880_at
Day 3 Intra/Day 3 Extra
0.102
5.4085E−03

4
HG1763-
The Institute
—
325_s_at
Day 3 Intra/Day 3 Extra
0.038
6.4653E−03

HT178
for

325_s_at
Day 7 Intra/Day 7 Control
0.060
1.7598E−03

Genomic

325_s_at
Day 3 Intra/Day 3 Control
0.073
2.6304E−04

Research

325_s_at
Day 0 Intra/Day 0 Control
0.091
6.8631E−04

5
2167
Entrez Gene
fatty acid binding protein 4, adipocyte
38430_at
Day 7 Intra/Day 7 Extra
0.053
1.3371E−03

38430_at
Day 7 Intra/Day 7 Control
0.075
4.2884E−03

6
3283
Entrez Gene
hydroxy-delta-5-steroid dehydrogenase, 3
35721_at
Day 0 Intra/Day 0 Peri
0.062
4.4497E−03

beta- and steroid delta-isomerase 1

7
6288
Entrez Gene
serum amyloid A1
33272_at
Day 3 Intra/Day 3 Extra
0.069
6.8147E−03

33272_at
Day 7 Intra/Day 7 Extra
0.117
4.3324E−03

8
9415
Entrez Gene
fatty acid desaturase 2
32190_at
Day 0 Intra/Day 0 Peri
0.081
5.6381E−04

32190_at
Day 7 Intra/Day 7 Peri
0.201
7.6424E−03

9
247
Entrez Gene
arachidonate 15-lipoxygenase, second type
37430_at
Day 0 Intra/Day 0 Peri
0.096
4.5492E−03

10
1690
Entrez Gene
coagulation factor C homolog, cochlin
34190_at
Day 3 Intra/Day 3 Extra
0.129
1.6089E−03

(Limulus polyphemus)

12
HG371-
The Institute
—
700_s_at
Day 0 Intra/Day 0 Peri
0.143
4.4849E−03

HT2638
for

Genomic

Research

13
125
Entrez Gene
alcohol dehydrogenase IB (class I), beta
35730_at
Day 3 Intra/Day 0 Intra
0.162
9.2302E−03

polypeptide

16
L09190
GenBank
Full-length cDNA clone CS0DI027YJ05 of
37635_at
Day 3 Intra/Day 3 Peri
0.206
2.8404E−03

Placenta Cot 25-normalized of Homo sapiens

(human)

18
7123
Entrez Gene
C-type lectin domain family 3, member B
36569_at
Day 3 Intra/Day 0 Intra
0.243
7.7786E−03

19
10351
Entrez Gene
ATP-binding cassette, sub-family A (ABC1),
35717_at
Day 3 Intra/Day 0 Intra
0.279
3.1166E−03

member 8
35717_at
Day 3 Intra/Day 3 Peri
0.305
5.8783E−04

20
AB011538
GenBank
CDNA clone IMAGE: 5922621
35324_at
Day 3 Intra/Day 0 Intra
0.280
3.8006E−03

21
3131
Entrez Gene
Hepatic leukemia factor
38627_at
Day 3 Intra/Day 0 Intra
0.289
1.1838E−03

38627_at
Day 7 Intra/Day 0 Intra
0.325
6.7101E−03

23
4211
Entrez Gene
Meis1, myeloid ecotropic viral integration site
40763_at
Day 3 Intra/Day 0 Intra
0.324
4.5206E−03

1 homolog (mouse)

24
2053
Entrez Gene
epoxide hydrolase 2, cytoplasmic
41473_at
Day 3 Intra/Day 0 Intra
0.327
3.5922E−03

25
4253
Entrez Gene
CTAGE family, member 5
41615_at
Day 3 Intra/Day 0 Intra
0.330
3.8948E−03

26
5271
Entrez Gene
serpin peptidase inhibitor, clade B
36312_at
Day 7 Intra/Day 7 Extra
0.482
4.6083E−03

(ovalbumin), member 8

27
3119
Entrez Gene
major histocompatibility complex, class II,
36878_f_at
Day 0 Intra/Day 0 Control
0.350
9.9683E−03

DQ bela 1

30
3885
Entrez Gene
keratin, hair, acidic, 4
34012_at
Day 0 Intra/Day 0 Peri
0.352
4.5590E−03

32
11075
Entrez Gene
stathmin-like 2
38800_at
Day 3 Intra/Day 0 Intra
0.356
5.6882E−03

33
3075
Entrez Gene
complement factor H
32250_at
Day 7 Intra/Day 0 Intra
0.356
2.4648E−03

34
10458
Entrez Gene
BAI1-associated protein 2
37760_at
Day 7 Intra/Day 3 Intra
0.799
8.1747E−03

35
9086
Entrez Gene
eukaryotic translation initiation factor 1A, Y-
40097_at
Day 3 Intra/Day 0 Intra
0.358
8.6154E−03

linked

36
2273
Entrez Gene
four and a half LIM domains 1
32542_at
Day 3 Intra/Day 0 Intra
0.367
5.7500E−03

40
4223
Entrez Gene
mesenchyme homeo box 2 (growth arrest-
40398_s_at
Day 3 Intra/Day 0 Intra
0.376
7.2046E−03

specific homeo box)

41
3400
Entrez Gene
inhibitor of DNA binding 4, dominant negative
41536_at
Day 3 Intra/Day 0 Intra
0.381
8.0900E−05

helix-loop-helix protein
41536_at
Day 7 Intra/Day 0 Intra
0.410
2.1354E−03

41536_at
Day 3 Intra/Day 3 Control
0.488
2.0560E−03

43
8710
Entrez Gene
serpin peptidase inhibitor, clade B
35577_at
Day 0 Intra/Day 0 Control
0.489
6.7433E−03

(ovalbumin), member 7
35577_at
Day 3 Intra/Day 3 Control
0.566
9.3574E−03

44
2194
Entrez Gene
fatty acid synthase
38429_at
Day 0 Intra/Day 0 Peri
0.386
9.3714E−03

47
406
Entrez Gene
aryl hydrocarbon receptor nuclear
36896_s_at
Day 3 Intra/Day 3 Control
0.391
9.1974E−03

translocator-like

48
9452
Entrez Gene
integral membrane protein 2A
40775_at
Day 3 Intra/Day 0 Intra
0.392
3.3491E−03

40775_at
Day 7 Intra/Day 0 Intra
0.400
2.0273E−03

49
63928
Entrez Gene
hepatocellular carcinoma antigen gene 520
33007_at
Day 3 Intra/Day 3 Control
0.466
7.7206E−03

51
5354
Entrez Gene
proteolipid protein 1 (Pelizaeus-Merzbacher
41158_at
Day 3 Intra/Day 0 Intra
0.403
1.1357E−04

disease, spastic paraplegia 2,
41158_at
Day 7 Intra/Day 0 Intra
0.503
1.7500E−03

uncomplicated)

54
224
Entrez Gene
aldehyde dehydrogenase 3 family, member
40409_at
Day 3 Intra/Day 3 Control
0.410
5.0007E−03

A2
40409_at
Day 3 Intra/Day 0 Intra
0.466
8.5061E−04

55
90634
Entrez Gene
hypothetical gene CG018
34239_at
Day 3 Intra/Day 3 Control
0.472
5.9625E−03

57
23242
Entrez Gene
cordon-bleu homolog (mouse)
35669_at
Day 3 Intra/Day 0 Intra
0.414
5.3389E−03

35669_at
Day 3 Intra/Day 3 Control
0.417
3.3977E−03

35669_at
Day 3 Intra/Day 3 Extra
0.522
4.0595E−04

61
M11119
GenBank
—
38850_at
Day 3 Intra/Day 0 Intra
0.428
8.8745E−03

62
9687
Entrez Gene
GREB1 protein
38875_r_at
Day 7 Intra/Day 0 Intra
0.428
1.0961E−04

63
51097
Entrez Gene
saccharopine dehydrogenase (putative)
34862_at
Day 7 Intra/Day 0 Intra
0.680
6.5823E−03

67
9145
Entrez Gene
synaptogyrin 1
35354_at
Day 7 Intra/Day 0 Intra
0.432
1.9735E−03

35354_at
Day 3 Intra/Day 0 Intra
0.469
5.7597E−03

68
1117
Entrez Gene
chitinase 3-like 2
31891_at
Day 0 Intra/Day 0 Peri
0.432
5.3219E−04

69
13
Entrez Gene
arylacetamide deacetylase (esterase)
36512_at
Day 3 Intra/Day 3 Extra
0.434
1.5905E−04

73
57798
Entrez Gene
GATA zinc finger domain containing 1
34195_at
Day 3 Intra/Day 3 Peri
0.441
6.2766E−04

75
26
Entrez Gene
amiloride binding protein 1 (amine oxidase
37186_s_at
Day 3 Intra/Day 3 Extra
0.443
5.1668E−03

(copper-containing))

76
AL080082
GenBank
MRNA; cDNA DKFZp564G1162 (from clone
35581_at
Day 3 Intra/Day 0 Intra
0.444
9.2254E−03

DKFZp564G1162)

79
56288
Entrez Gene
par-3 partitioning defective 3 homolog
40973_at
Day 3 Intra/Day 3 Control
0.533
5.0405E−03

(C. elegans)

80
26154
Entrez Gene
ATP-binding cassette, sub-family A (ABC1),
31754_at
Day 3 Intra/Day 3 Extra
0.557
5.7474E−03

member 12

82
1410
Entrez Gene
crystallin, alpha B
32243_g_at
Day 3 Intra/Day 3 Extra
0.468
5.9480E−03

84
10733
Entrez Gene
polo-like kinase 4 (Drosophila)
975_at
Day 7 Intra/Day 7 Extra
0.455
5.4588E−03

85
8848
Entrez Gene
TSC22 domain family, member 1
39032_at
Day 3 Intra/Day 0 Intra
0.455
1.8273E−03

87
5264
Entrez Gene
phytanoyl-CoA hydroxylase (Refsum
32724_at
Day 3 Intra/Day 0 Intra
0.465
4.1244E−03

disease)

88
10529
Entrez Gene
nebulette
34873_at
Day 3 Intra/Day 3 Control
0.466
5.5136E−03

89
60481
Entrez Gene
ELOVL family member 5, elongation of long
33821_at
Day 0 Intra/Day 0 Peri
0.468
8.7794E−03

chain fatty acids (FEN1/Elo2, SUR4/Elo3-

like, yeast)

91
10248
Entrez Gene
processing of precursor 7, ribonuclease P
32213_at
Day 7 Intra/Day 3 Intra
0.470
9.0083E−03

subunit (S. cerevisiae)

92
1545
Entrez Gene
cytochrome P450, family 1, subfamily B,
40071_at
Day 7 Intra/Day 7 Peri
0.471
9.8480E−03

polypeptide 1

93
1152
Entrez Gene
creatine kinase, brain
40863_r_at
Day 7 Intra/Day 7 Control
0.472
4.0142E−03

94
10450
Entrez Gene
peptidylprolyl isomerase E (cyclophilin E)
34365_at
Day 3 Intra/Day 3 Control
0.518
4.1270E−03

96
10090
Entrez Gene
uronyl-2-sulfotransferase
41859_at
Day 3 Intra/Day 0 Intra
0.474
1.8927E−03

41859_at
Day 7 Intra/Day 0 Intra
0.521
1.4198E−04

98
352961
Entrez Gene
MHC class I mRNA fragment 3.8-1
34934_at
Day 3 Intra/Day 0 Intra
0.479
6.5297E−03

99
10314
Entrez Gene
LanC lantibiotic synthetase component C-like
39441_at
Day 0 Intra/Day 0 Control
0.488
6.0119E−04

1 (bacterial)

100
10628
Entrez Gene
thioredoxin interacting protein
31508_at
Day 3 Intra/Day 0 Intra
0.482
9.0159E−03

102
6038
Entrez Gene
ribonuclease, RNase A family, 4
32664_at
Day 3 Intra/Day 0 Intra
0.483
2.7472E−03

32664_at
Day 7 Intra/Day 0 Intra
0.569
4.9291E−04

104
6414
Entrez Gene
selenoprotein P, plasma, 1
34363_at
Day 3 Intra/Day 0 Intra
0.488
6.0330E−03

105
9987
Entrez Gene
Heterogeneous nuclear ribonucleoprotein D-
32393_s_at
Day 3 Intra/Day 3 Peri
0.489
1.9407E−03

like

107
4163
Entrez Gene
mutated in colorectal cancers
35561_at
Day 0 Intra/Day 0 Peri
0.489
6.2800E−05

111
2947
Entrez Gene
glutathione S-transferase M3 (brain)
1120_at
Day 7 Intra/Day 0 Intra
0.494
7.1503E−03

114
8864
Entrez Gene
period homolog 2 (Drosophila)
35008_at
Day 3 Intra/Day 0 Intra
0.497
4.3990E−03

117
104
Entrez Gene
adenosine deaminase, RNA-specific, B1
38748_at
Day 3 Intra/Day 0 Intra
0.499
8.5077E−04

(RED1 homolog rat)
38748_at
Day 7 Intra/Day 0 Intra
0.541
1.9004E−03

119
6662
Entrez Gene
SRY (sex determining region Y)-box 9
33436_at
Day 0 Intra/Day 0 Peri
0.521
8.5777E−03

(campomelic dysplasia, autosomal sex-

reversal)

122
9831
Entrez Gene
zinc finger protein 623
39954_r_at
Day 3 Intra/Day 0 Intra
0.505
3.3609E−03

123
1573
Entrez Gene
cytochrome P450, family 2, subfamily J,
501_g_t
Day 3 Intra/Day 3 Control
0.529
4.2791E−03

polypeptide 2

124
22982
Entrez Gene
KIAA0934
33408_at
Day 3 Intra/Day 0 Intra
0.506
3.1621E−03

125
51710
Entrez Gene
zinc finger protein 44 (KOX 7)
35409_r_at
Day 3 Intra/Day 3 Peri
0.507
5.1572E−03

126
2533
Entrez Gene
FYN binding protein (FYB-120/130)
41819_at
Day 3 Intra/Day 3 Peri
0.507
3.0115E−03

127
9857
Entrez Gene
centrosome-associated protein 350
33805_at
Day 3 Intra/Day 3 Peri
0.508
4.3400E−05

128
9891
Entrez Gene
NUAK family, SNF1-like kinase, 1
33787_at
Day 3 Intra/Day 0 Intra
0.508
1.4528E−03

131
23051
Entrez Gene
zinc fingers and homeoboxes 3
40461_at
Day 3 Intra/Day 0 Intra
0.513
6.7006E−04

40461_at
Day 7 Intra/Day 0 Intra
0.609
6.3269E−03

133
3422
Entrez Gene
isopentenyl-diphosphate delta Isomerase 1
36985_at
Day 7 Intra/Day 7 Extra
0.515
5.4407E−03

134
7728
Entrez Gene
zinc finger protein 175
37500_at
Day 7 Intra/Day 7 Peri
0.515
4.1955E−03

135
36
Entrez Gene
acyl-Coenzyme A dehydrogenase,
40673_at
Day 3 Intra/Day 3 Control
0.515
1.3679E−03

short/branched chain

139
10965
Entrez Gene
acyl-CoA thioesterase 2
36625_at
Day 7 Intra/Day 7 Control
0.518
7.3351E−04

140
10284
Entrez Gene
Sin3-associated polypeptide, 18 kDa
41277_at
Day 3 Intra/Day 0 Intra
0.520
2.4318E−03

143
7073
Entrez Gene
TIA1 cytotoxic granule-associated RNA
41761_at
Day 3 Intra/Day 0 Intra
0.521
4.5836E−03

binding protein-like 1

145
8853
Entrez Gene
development and differentiation enhancing
39410_at
Day 7 Intra/Day 0 Intra
0.521
2.9990E−03

factor 2

146
4968
Entrez Gene
8-oxoguanine DNA glycosylase
38335_at
Day 3 Intra/Day 0 Intra
0.522
7.5868E−04

38335_at
Day 7 Intra/Day 0 Intra
0.626
6.6349E−03

147
2110
Entrez Gene
electron-transferring-flavoprotein
33494_at
Day 7 Intra/Day 7 Extra
0.523
1.1689E−03

dehydrogenase

151
55187
Entrez Gene
vacuolar protein sorting 13D (yeast)
32743_at
Day 3 Intra/Day 0 Intra
0.527
2.5585E−03

153
9140
Entrez Gene
ATG12 autophagy related 12 homolog
32720_at
Day 3 Intra/Day 3 Peri
0.530
2.7861E−04

(S. cerevisiae)

155
23506
Entrez Gene
KIAA0240
38892_at
Day 3 Intra/Day 0 Intra
0.531
5.3954E−03

158
6595
Entrez Gene
SWI/SNF related, matrix associated, actin
40961_at
Day 3 Intra/Day 0 Intra
0.533
6.2437E−03

dependent regulator of chromatin, subfamily

a, member 2

159
5110
Entrez Gene
Protein-L-isoaspartate (D-aspartate) O-
37737_at
Day 7 Intra/Day 7 Extra
0.534
2.8151E−03

methyltransferase

161
201229
Entrez Gene
hypothetical protein LOC201229
39557_at
Day 3 Intra/Day 0 Intra
0.535
2.3943E−03

162
22909
Entrez Gene
KIAA1018 protein
36458_at
Day 3 Intra/Day 0 Intra
0.536
6.1234E−03

163
51099
Entrez Gene
Abhydrolase domain containing 5
33309_at
Day 3 Intra/Day 3 Peri
0.536
9.8735E−03

164
114882
Entrez Gene
oxysterol binding protein-like 8
41438_at
Day 3 Intra/Day 3 Peri
0.536
3.0621E−03

166
10653
Entrez Gene
serine peptidase inhibitor, Kunitz type, 2
34348_at
Day 7 Intra/Day 7 Extra
0.699
5.3002E−03

168
399563
Entrez Gene
hypothetical protein FLJ43806
37151_at
Day 7 Intra/Day 0 Intra
0.542
7.7014E−03

171
1662
Entrez Gene
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
831_at
Day 7 Intra/Day 7 Extra
0.544
5.2360E−03

172
5130
Entrez Gene
phosphate cytidylyltransferase 1, choline,
39285_at
Day 0 Intra/Day 0 Peri
0.545
2.3355E−03

alpha

174
26235
Entrez Gene
F-box and leucine-rich repeat protein 4
39987_at
Day 7 Intra/Day 7 Peri
0.546
3.2958E−03

176
202
Entrez Gene
absent in melanoma 1
32112_s_at
Day 3 Intra/Day 3 Extra
0.617
9.6499E−03

177
9774
Entrez Gene
BCL2-associated transcription factor 1
38050_at
Day 7 Intra/Day 7 Extra
0.547
4.7061E−03

181
4232
Entrez Gene
mesoderm specific transcript homolog
37749_at
Day 7 Intra/Day 7 Extra
0.553
9.8929E−04

(mouse)

182
2145
Entrez Gene
enhancer of zeste homolog 1 (Drosophila)
32259_at
Day 7 Intra/Day 0 Intra
0.554
8.0450E−03

184
U73737
GenBank
—
1017_at
Day 3 Intra/Day 3 Peri
0.556
4.6650E−03

189
10300
Entrez Gene
katanin p80 (WD repeat containing) subunit
40976_at
Day 3 Intra/Day 3 Extra
0.559
9.1699E−03

B1

251
8776
Entrez Gene
myotubularin related protein 1
34654_at
Day 3 Intra/Day 3 Extra
0.598
1.6699E−03

34654_at
Day 3 Intra/Day 3 Control
0.631
5.7609E−03

253
AL080234
GenBank
Full-length cDNA clone CS0DM001YA04 of
38070_at
Day 7 Intra/Day 0 Intra
0.598
4.0826E−03

Fetal liver of Homo sapiens (human)

255
23234
Entrez Gene
DnaJ (Hsp40) homolog, subfamily C,
41569_at
Day 7 Intra/Day 7 Extra
0.615
8.2268E−03

member 9

256
94239
Entrez Gene
H2A histone family, member V
39046_at
Day 3 Intra/Day 0 Intra
0.600
7.9321E−03

39046_at
Day 7 Intra/Day 0 Intra
0.650
5.0612E−03

257
AI557912
GenBank
translocase of outer mitochondrial membrane
39025_at
Day 7 Intra/Day 0 Intra
0.601
3.8343E−03

7 homolog (yeast) /// hypothetical protein
39025_at
Day 7 Intra/Day 7 Control
0.727
5.2071E−03

LOC201725

261
6651
Entrez Gene
SON DNA binding protein
39096_at
Day 7 Intra/Day 0 Intra
0.607
3.4000E−03

39096_at
Day 7 Intra/Day 7 Peri
0.641
4.2992E−03

39096_at
Day 7 Intra/Day 3 Intra
0.710
4.2168E−03

263
6427
Entrez Gene
splicing factor, arginine/serine-rich 2
36111_s_at
Day 7 Intra/Day 7 Extra
0.665
1.5173E−04

36111_s_at
Day 7 Intra/Day 3 Intra
0.709
6.0916E−03

264
221749
Entrez Gene
chromosome 6 open reading frame 145
34246_at
Day 3 Intra/Day 0 Intra
0.608
3.6829E−03

267
54665
Entrez Gene
round spermatid basic protein 1
37828_at
Day 3 Intra/Day 0 Intra
0.610
7.8572E−04

270
3301
Entrez Gene
DnaJ (Hsp40) homolog, subfamily A,
39118_at
Day 7 Intra/Day 7 Extra
0.611
5.7425E−03

member 1

272
22826
Entrez Gene
DnaJ (Hsp40) homolog, subfamily C,
36156_at
Day 0 Intra/Day 0 Control
0.612
5.7794E−03

member 8

273
23090
Entrez Gene
zinc finger protein 423
34950_at
Day 7 Intra/Day 7 Peri
0.623
7.6235E−03

274
64112
Entrez Gene
modulator of apoptosis 1
34767_at
Day 3 Intra/Day 0 Intra
0.614
4.4658E−03

275
10497
Entrez Gene
unc-13 homolog B (C. elegans)
40087_at
Day 0 Intra/Day 0 Control
0.769
3.3634E−03

282
23392
Entrez Gene
KIAA0368
34414_at
Day 7 Intra/Day 0 Intra
0.616
1.2883E−03

283
5934
Entrez Gene
retinoblastoma-like 2 (p130)
32597_at
Day 3 Intra/Day 0 Intra
0.616
8.7510E−03

284
4781
Entrez Gene
Nuclear factor I/B
41229_at
Day 3 Intra/Day 0 Intra
0.616
3.0477E−03

288
3418
Entrez Gene
isocitrate dehydrogenase 2 (NADP+),
32332_at
Day 0 Intra/Day 0 Peri
0.617
1.2980E−03

mitochondrial

289
9
Entrez Gene
N-acetyltransferase 1 (arylamine N-
38187_at
Day 7 Intra/Day 7 Extra
0.619
5.7524E−03

acetyltransferase)

290
25797
Entrez Gene
glutaminyl-peptide cyclotransferase
35966_at
Day 3 Intra/Day 0 Intra
0.619
4.9522E−03

(glutaminyl cyclase)

297
8888
Entrez Gene
MCM3 minichromosome maintenance
40469_at
Day 7 Intra/Day 7 Extra
0.624
4.8160E−03

deficient 3 (S. cerevisiae) associated protein

298
10289
Entrez Gene
translation factor sui1 homolog
33351_at
Day 3 Intra/Day 0 Intra
0.673
1.7268E−03

302
24139
Entrez Gene
echinoderm microtubule associated protein
41328_s_at
Day 0 Intra/Day 0 Peri
0.627
4.4037E−03

like 2

305
23351
Entrez Gene
KIAA0323
32592_at
Day 0 Intra/Day 0 Control
0.679
8.2136E−03

310
22903
Entrez Gene
BTB (POZ) domain containing 3
37755_at
Day 3 Intra/Day 0 Intra
0.631
9.7703E−03

311
4681
Entrez Gene
neuroblastoma, suppression of tumorigenicity 1
37005_at
Day 0 Intra/Day 0 Peri
0.631
3.2813E−03

312
10301
Entrez Gene
deleted in lymphocytic leukemia, 1
33791_at
Day 7 Intra/Day 0 Intra
0.631
8.9965E−03

33791_at
Day 3 Intra/Day 0 Intra
0.726
6.7457E−03

313
AF052138
GenBank
FLJ35348 /// Bromodomain containing 3
41841_at
Day 3 Intra/Day 0 Intra
0.632
4.2490E−03

315
8930
Entrez Gene
methyl-CpG binding domain protein 4
34386_at
Day 7 Intra/Day 7 Extra
0.634
3.7388E−03

319
1428
Entrez Gene
crystallin, mu
38285_at
Day 3 Intra/Day 0 Intra
0.636
1.2448E−03

320
10614
Entrez Gene
Hexamethylene bis-acetamide inducible 1
40220_at
Day 3 Intra/Day 0 Intra
0.636
3.7740E−03

324
1340
Entrez Gene
cytochrome c oxidase subunit Vib
40872_at
Day 3 Intra/Day 3 Extra
0.698
6.3894E−03

polypeptide 1 (ubiquitous)

329
4026
Entrez Gene
LIM domain containing preferred
41195_at
Day 3 Intra/Day 3 Peri
0.639
3.3595E−03

translocation partner in lipoma

334
6230
Entrez Gene
ribosomal protein S25
31573_at
Day 7 Intra/Day 0 Intra
0.643
9.4033E−03

337
27067
Entrez Gene
staufen, RNA binding protein, homolog 2
38341_at
Day 3 Intra/Day 3 Extra
0.645
8.2036E−03

(Drosophila)

341
9521
Entrez Gene
eukaryotic translation elongation factor 1
40587_s_at
Day 7 Intra/Day 3 Intra
0.647
1.9928E−03

epsilon 1

342
1054
Entrez Gene
CCAAT/enhancer binding protein (C/EBP),
39219_at
Day 7 Intra/Day 7 Extra
0.676
1.0916E−03

gamma

352
8732
Entrez Gene
RNA guanylyltransferase and 5′-phosphatase
35202_at
Day 7 Intra/Day 7 Extra
0.654
1.2688E−03

356
51567
Entrez Gene
TRAF and TNF receptor associated protein
34825_at
Day 3 Intra/Day 3 Extra
0.655
3.0500E−05

360
3298
Entrez Gene
heat shock transcription factor 2
202_at
Day 7 Intra/Day 0 Intra
0.658
7.1609E−03

361
4677
Entrez Gene
asparaginyl-tRNA synthetase
41241_at
Day 0 Intra/Day 0 Control
0.658
3.0519E−03

363
23384
Entrez Gene
KIAA0376 protein
34837_at
Day 3 Intra/Day 0 Intra
0.659
2.3071E−03

365
6635
Entrez Gene
small nuclear ribonucleoprotein polypeptide E
38679_g_at
Day 7 Intra/Day 7 Extra
0.661
3.7759E−04

38679_g_at
Day 7 Intra/Day 3 Intra
0.697
1.8800E−05

369
7004
Entrez Gene
TEA domain family member 4
41037_at
Day 7 Intra/Day 7 Extra
0.710
7.7243E−03

41037_at
Day 0 Intra/Day 0 Peri
0.755
4.0427E−03

371
4832
Entrez Gene
non-metastatic cells 3, protein expressed in
197_at
Day 3 Intra/Day 3 Control
0.663
6.9663E−03

372
10557
Entrez Gene
ribonuclease P/MRP 38 kDa subunit
41040_at
Day 7 Intra/Day 7 Extra
0.667
4.5174E−03

373
26156
Entrez Gene
ribosomal L1 domain containing 1
39418_at
Day 7 Intra/Day 3 Intra
0.691
5.6288E−03

376
26053
Entrez Gene
autism susceptibility candidate 2
35648_at
Day 3 Intra/Day 0 Intra
0.667
3.9622E−03

377
56339
Entrez Gene
Methyltransferase like 3
32244_at
Day 3 Intra/Day 0 Intra
0.667
8.9345E−04

32244_at
Day 3 Intra/Day 3 Extra
0.726
7.6780E−03

382
10038
Entrez Gene
poly (ADP-ribose) polymerase family,
34756_g_at
Day 7 Intra/Day 7 Extra
0.669
7.1429E−03

member 2

386
10904
Entrez Gene
bladder cancer associated protein
35267_g_at
Day 7 Intra/Day 0 Intra
0.672
2.1451E−03

387
7411
Entrez Gene
von Hippel-Lindau binding protein 1
171_at
Day 7 Intra/Day 7 Extra
0.672
7.7370E−03

390
1349
Entrez Gene
cytochrome c oxidase subunit VIIb
36687_at
Day 7 Intra/Day 3 Intra
0.673
1.8885E−03

391
54462
Entrez Gene
KIAA1128
37617_at
Day 3 Intra/Day 0 Intra
0.674
5.5416E−03

37617_at
Day 3 Intra/Day 3 Control
0.696
9.3133E−03

392
80003
Entrez Gene
pecanex-like 2 (Drosophila)
39650_s_at
Day 3 Intra/Day 0 Intra
0.674
6.1109E−03

393
25972
Entrez Gene
unc-50 homolog (C. elegans)
39442_at
Day 7 Intra/Day 7 Extra
0.675
9.6835E−03

394
64795
Entrez Gene
hypothetical protein FLJ13910
36580_at
Day 3 Intra/Day 0 Intra
0.676
3.2610E−03

397
7743
Entrez Gene
zinc finger protein 189
36072_at
Day 3 Intra/Day 0 Intra
0.678
3.7246E−03

399
50813
Entrez Gene
COP6 constitutive photomorphogenic
34404_at
Day 0 Intra/Day 0 Peri
0.681
4.7805E−03

homolog subunit 7A (Arabidopsis)

400
3156
Entrez Gene
3-hydroxy-3-methylglutaryl-Coenzyme A
39328_at
Day 3 Intra/Day 3 Extra
0.681
6.1525E−03

reductase

405
2961
Entrez Gene
general transcription factor IIE, polypeptide 2,
37295_at
Day 7 Intra/Day 7 Extra
0.796
1.4862E−03

beta 34 kDa

409
4170
Entrez Gene
myeloid cell leukemia sequence 1 (BCL2-
277_at
Day 3 Intra/Day 3 Extra
0.684
9.6905E−03

related)

414
23112
Entrez Gene
trinucleotide repeat containing 6B
37487_at
Day 3 Intra/Day 3 Peri
0.688
3.9849E−03

417
9759
Entrez Gene
histone deacetylase 4
38271_at
Day 3 Intra/Day 0 Intra
0.689
4.9833E−03

418
4676
Entrez Gene
nucleosome assembly protein 1-like 4
32575_at
Day 7 Intra/Day 7 Extra
0.790
4.9890E−03

422
1749
Entrez Gene
distal-less homeo box 5
41087_at
Day 3 Intra/Day 0 Intra
0.689
3.6526E−03

427
22794
Entrez Gene
cancer susceptibility candidate 3
38437_at
Day 7 Intra/Day 0 Intra
0.692
2.7057E−03

38437_at
Day 3 Intra/Day 0 Intra
0.742
4.1247E−03

428
322
Entrez Gene
amyloid beta (A4) precursor protein binding,
1101_at
Day 7 Intra/Day 0 Intra
0.692
1.6594E−03

family B, member 1 (Fe65)

430
6637
Entrez Gene
small nuclear ribonucleoprotein polypeptide G
37337_at
Day 7 Intra/Day 3 Intra
0.693
3.9690E−03

435
889
Entrez Gene
KRIT1, ankyrin repeat containing
34031_i_at
Day 3 Intra/Day 3 Peri
0.694
4.9207E−03

439
2549
Entrez Gene
GRB2-associated binding protein 1
33997_at
Day 7 Intra/Day 0 Intra
0.695
2.4091E−04

33997_at
Day 3 Intra/Day 0 Intra
0.710
2.0825E−03

443
23125
Entrez Gene
calmodulin binding transcription activator 2
41421_at
Day 7 Intra/Day 0 Intra
0.696
8.6760E−03

444
2926
Entrez Gene
G-rich RNA sequence binding factor 1
32595_at
Day 7 Intra/Day 7 Extra
0.696
6.0979E−03

447
22849
Entrez Gene
cytoplasmic polyadenylation element binding
34931_at
Day 3 Intra/Day 0 Intra
0.697
6.8691E−03

protein 3

448
10106
Entrez Gene
CTD (carboxy-terminal domain, RNA
41202_s_at
Day 3 Intra/Day 0 Intra
0.698
3.5449E−03

polymerase II, polypeptide A) small

phosphatase 2

450
10329
Entrez Gene
transmembrane protein 5
37445_at
Day 3 Intra/Day 3 Extra
0.700
2.4850E−03

451
26959
Entrez Gene
HMG-box transcription factor 1
39809_at
Day 3 Intra/Day 0 Intra
0.701
9.4669E−03

452
539
Entrez Gene
ATP synthase, H+ transporting, mitochondrial
37029_at
Day 7 Intra/Day 7 Control
0.784
7.2352E−03

F1 complex, O subunit (oligomycin sensitivity

conferring protein)

453
10542
Entrez Gene
hepatitis B virus x interacting protein
38054_at
Day 7 Intra/Day 7 Extra
0.782
3.3831E−03

454
8624
Entrez Gene
Down syndrome critical region gene 2
36088_at
Day 7 Intra/Day 3 Intra
0.704
8.0554E−03

456
5431
Entrez Gene
polymerase (RNA) II (DNA directed)
39746_at
Day 7 Intra/Day 7 Extra
0.705
2.3347E−03

polypeptide B, 140 kDa

464
22882
Entrez Gene
zinc fingers and homeoboxes 2
41503_at
Day 7 Intra/Day 7 Peri
0.750
6.4066E−03

467
1329
Entrez Gene
cytochrome c oxidase subunit Vb
39921_at
Day 7 Intra/Day 7 Control
0.718
5.7364E−03

468
51020
Entrez Gene
HD domain containing 2
34359_at
Day 7 Intra/Day 0 Intra
0.712
2.4876E−03

34359_at
Day 7 Intra/Day 7 Extra
0.777
2.8509E−03

473
3054
Entrez Gene
host cell factor C1 (VP16-accessory protein)
37910_at
Day 0 Intra/Day 0 Peri
0.718
6.3341E−03

474
79026
Entrez Gene
AHNAK nucleoprotein (desmoyokin)
37027_at
Day 7 Intra/Day 0 Intra
0.718
8.1471E−03

479
10611
Entrez Gene
PDZ and LIM domain 5
37366_at
Day 3 Intra/Day 3 Extra
0.722
2.3752E−03

482
9813
Entrez Gene
KIAA0494
41830_at
Day 3 Intra/Day 0 Intra
0.725
3.4757E−03

489
26100
Entrez Gene
WIPI49-like protein 2
33392_at
Day 3 Intra/Day 3 Extra
0.731
6.9435E−03

494
10075
Entrez Gene
HECT, UBA and WWE domain containing 1
34374_g_at
Day 0 Intra/Day 0 Peri
0.733
2.9867E−03

500
23259
Entrez Gene
DDHD domain containing 2
35177_at
Day 7 Intra/Day 0 Intra
0.736
6.5771E−03

509
51304
Entrez Gene
zinc finger, DHHC-type containing 3
39751_at
Day 3 Intra/Day 3 Extra
0.744
7.7468E−03

513
10541
Entrez Gene
acidic (leucine-rich) nuclear phosphoprotein
38479_at
Day 7 Intra/Day 7 Extra
0.747
1.6161E−03

32 family, member B

515
23379
Entrez Gene
KIAA0947 protein
41595_at
Day 7 Intra/Day 7 Extra
0.751
2.7370E−03

519
9215
Entrez Gene
like-glycosyltransferase
41346_at
Day 3 Intra/Day 0 Intra
0.754
4.1376E−03

521
10241
Entrez Gene
nuclear domain 10 protein
40063_at
Day 3 Intra/Day 0 Intra
0.755
7.6513E−03

526
1955
Entrez Gene
EGF-like-domain, multiple 5
36488_at
Day 3 Intra/Day 0 Intra
0.759
7.4685E−03

530
4601
Entrez Gene
MAX interactor 1
39072_at
Day 3 Intra/Day 0 Intra
0.762
4.0454E−03

532
1998
Entrez Gene
E74-like factor 2 (ets domain transcription
507_s_at
Day 7 Intra/Day 0 Intra
0.763
4.9954E−03

factor)

537
7693
Entrez Gene
zinc finger protein 134 (clone pHZ-15)
36295_at
Day 3 Intra/Day 0 Intra
0.764
9.8397E−03

545
23294
Entrez Gene
ankyrin repeat and sterile alpha motif domain
40971_at
Day 3 Intra/Day 0 Intra
0.769
7.4093E−03

containing 1

548
5636
Entrez Gene
phosphoribosyl pyrophosphate synthetase-
41853_at
Day 3 Intra/Day 3 Extra
0.772
9.6928E−03

associated protein 2

550
9703
Entrez Gene
KIAA0100 gene product
39783_at
Day 0 Intra/Day 0 Peri
0.773
4.2046E−03

551
10294
Entrez Gene
DnaJ (Hsp40) homolog, subfamily A,
34201_at
Day 3 Intra/Day 0 Intra
0.775
2.1191E−03

member 2

552
9741
Entrez Gene
lysosomal-associated protein
39019_at
Day 3 Intra/Day 0 Intra
0.776
6.0768E−03

transmembrane 4 alpha
39019_at
Day 7 Intra/Day 0 Intra
0.815
9.6992E−03

554
10556
Entrez Gene
ribonuclease P/MRP 30 kDa subunit
39702_at
Day 3 Intra/Day 3 Extra
0.778
8.7433E−03

555
9562
Entrez Gene
multiple inositol polyphosphate histidine
38325_at
Day 3 Intra/Day 3 Extra
0.779
8.9541E−03

phosphatase, 1

556
9528
Entrez Gene
transmembrane protein 59
39033_at
Day 3 Intra/Day 3 Control
0.779
6.9035E−03

39033_at
Day 3 Intra/Day 0 Intra
0.787
2.6172E−04

557
5326
Entrez Gene
pieiomorphic adenoma gene-like 2
40061_at
Day 3 Intra/Day 3 Peri
0.779
7.8774E−03

561
670
Entrez Gene
biphenyl hydrolase-like (serine hydrolase;
40912_s_at
Day 0 Intra/Day 0 Control
0.784
7.7779E−03

breast epithelial mucin-associated antigen)

564
51780
Entrez Gene
jumonji domain containing 1B
33870_at
Day 3 Intra/Day 0 Intra
0.789
6.0617E−03

568
56270
Entrez Gene
WDR45-like
39185_at
Day 3 Intra/Day 3 Control
0.792
6.7923E−03

574
79073
Entrez Gene
hypothetical protein MGC5508
39693_at
Day 3 Intra/Day 3 Extra
0.797
7.6719E−03

587
369
Entrez Gene
v-raf murine sarcoma 3611 viral oncogene
1706_at
Day 7 Intra/Day 3 Intra
0.832
4.3502E−04

homolog

588
23
Entrez Gene
ATP-binding cassette, sub-family F (GCN20),
39141_at
Day 7 Intra/Day 3 Intra
0.837
5.3611E−03

member 1

589
25966
Entrez Gene
chromosome 21 open reading frame 25
32107_at
Day 7 Intra/Day 7 Extra
0.845
5.8404E−03

590
23644
Entrez Gene
autoantigen
36670_at
Day 3 Intra/Day 0 Intra
0.866
7.3351E−03

TABLE 21

Diagnostic Down

Gene
Public

Fold

ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Change
P value

1
4250
Entrez Gene
secretoglobin, family 2A, member 2
36329_at
Day 0 Intra/Day 0 Control
0.009
7.1701E−04

36329_at
Day 3 Intra/Day 3 Control
0.017
3.3179E−04

36329_at
Day 7 Intra/Day 7 Control
0.021
2.8985E−03

2
5304
Entrez Gene
prolactin-induced protein
41094_at
Day 0 Intra/Day 0 Control
0.032
5.1676E−04

41094_at
Day 7 Intra/Day 7 Control
0.076
9.5561E−03

41094_at
Day 3 Intra/Day 3 Control
0.094
1.9791E−04

3
10647
Entrez Gene
secretoglobin, family 1D, member 2
32880_at
Day 0 Intra/Day 0 Control
0.033
4.4000E−05

32880_at
Day 7 Intra/Day 7 Control
0.065
7.5456E−03

32880_at
Day 3 Intra/Day 3 Control
0.075
8.2511E−04

4
HG1763-
The Institute
—
325_s_at
Day 7 Intra/Day 7 Control
0.060
1.7598E−03

HT178
for Genomic

325_s_at
Day 3 Intra/Day 3 Control
0.073
2.6304E−04

Research

325_s_at
Day 0 Intra/Day 0 Control
0.091
6.8631E−04

5
2167
Entrez Gene
fatty acid binding protein 4, adipocyte
38430_at
Day 7 Intra/Day 7 Control
0.075
4.2884E−03

27
3119
Entrez Gene
major histocompatibility complex, class II,
36878_f_at
Day 0 Intra/Day 0 Control
0.350
9.9683E−03

DQ beta 1

41
3400
Entrez Gene
Inhibitor of DNA binding 4, dominant
41536_at
Day 3 Intra/Day 3 Control
0.488
2.0560E−03

negative helix-loop-helix protein

43
8710
Entrez Gene
serpin peptidase inhibitor, clade B (ovalbumin),
35577_at
Day 0 Intra/Day 0 Control
0.489
6.7433E−03

member 7
35577_at
Day 3 Intra/Day 3 Control
0.566
9.3574E−03

47
406
Entrez Gene
aryl hydrocarbon receptor nuclear
36896_s_at
Day 3 Intra/Day 3 Control
0.391
9.1974E−03

translocator-like

49
63928
Entrez Gene
hepatocellular carcinoma antigen gene 520
33007_at
Day 3 Intra/Day 3 Control
0.466
7.7206E−03

54
224
Entrez Gene
aldehyde dehydrogenase 3 family, member A2
40409_at
Day 3 Intra/Day 3 Control
0.410
5.0007E−03

55
90634
Entrez Gene
hypothetical gene CG018
34239_at
Day 3 Intra/Day 3 Control
0.472
5.9625E−03

57
23242
Entrez Gene
cordon-bleu homolog (mouse)
35669_at
Day 3 Intra/Day 3 Control
0.417
3.3977E−03

79
56288
Entrez Gene
par-3 partitioning defective 3 homolog
40973_at
Day 3 Intra/Day 3 Control
0.533
5.0405E−03

(C. elegans)

88
10529
Entrez Gene
nebulette
34873_at
Day 3 Intra/Day 3 Control
0.466
5.5136E−03

93
1152
Entrez Gene
creatine kinase, brain
40863_r_at
Day 7 Intra/Day 7 Control
0.472
4.0142E−03

94
10450
Entrez Gene
peptidylprolyl isomerase E (cyclophilin E)
34365_at
Day 3 Intra/Day 3 Control
0.518
4.1270E−03

99
10314
Entrez Gene
LanC lantibiotic synthetase component C-like 1
39441_at
Day 0 Intra/Day 0 Control
0.488
6.0119E−04

(bacterial)

123
1573
Entrez Gene
cytochrome P450, family 2, subfamily J,
501_g_at
Day 3 Intra/Day 3 Control
0.529
4.2791E−03

polypeptide 2

135
36
Entrez Gene
acyl-Coenzyme A dehydrogenase, short/branched
40673_at
Day 3 Intra/Day 3 Control
0.515
1.3679E−03

chain

139
10965
Entrez Gene
acyl-CoA thioesterase 2
36625_at
Day 7 Intra/Day 7 Control
0.518
7.3351E−04

200
8349
Entrez Gene
histone 2, H2be
33352_at
Day 3 Intra/Day 3 Control
0.570
6.1256E−03

203
115817
Entrez Gene
dehydrogenase/reductase (SDR family) member 1
39103_s_at
Day 0 Intra/Day 0 Control
0.592
1.8258E−03

217
987
Entrez Gene
LPS-responsive vesicle trafficking, beach and
35371_at
Day 3 Intra/Day 3 Control
0.652
2.1271E−03

anchor containing

236
HG3254-
The Institute
—
1163_at
Day 3 Intra/Day 3 Control
0.591
5.8755E−03

HT343
for Genomic

Research

251
8776
Entrez Gene
myotubularin related protein 1
34654_at
Day 3 Intra/Day 3 Control
0.631
5.7609E−03

257
AI557912
GenBank
translocase of outer mitochondrial membrane 7
39025_at
Day 7 Intra/Day 7 Control
0.727
5.2071E−03

homolog (yeast) /// hypothetical protein

LOC201725

272
22826
Entrez Gene
DnaJ (Hsp40) homolog, subfamily C, member 8
36166_at
Day 0 Intra/Day 0 Control
0.612
5.7794E−03

275
10497
Entrez Gene
unc-13 homolog B (C. elegans)
40087_at
Day 0 Intra/Day 0 Control
0.769
3.3634E−03

305
23351
Entrez Gene
KIAA0323
32592_at
Day 0 Intra/Day 0 Control
0.679
8.2136E−03

361
4677
Entrez Gene
asparaginyl-tRNA synthetase
41241_at
Day 0 Intra/Day 0 Control
0.658
3.0519E−03

371
4832
Entrez Gene
non-metastatic cells 3, protein expressed in
197_at
Day 3 Intra/Day 3 Control
0.663
6.9663E−03

391
54462
Entrez Gene
KIAA1128
37617_at
Day 3 Intra/Day 3 Control
0.696
9.3133E−03

452
539
Entrez Gene
ATP synthase, H+ transporting, mitochondrial F1
37029_at
Day 7 Intra/Day 7 Control
0.784
7.2352E−03

complex, O subunit (oligomycin sensitivity

conferring protein)

467
1329
Entrez Gene
cytochrome c oxidase subunit Vb
39921_at
Day 7 Intra/Day 7 Control
0.718
5.7364E−03

556
9528
Entrez Gene
transmembrane protein 59
39033_at
Day 3 Intra/Day 3 Control
0.779
6.9035E−03

561
670
Entrez Gene
biphenyl hydrolase-like (serine hydrolase; breast
40912_s_at
Day 0 Intra/Day 0 Control
0.784
7.7779E−03

epithelial mucin-associated antigen)

568
56270
Entrez Gene
WDR45-like
39185_at
Day 3 Intra/Day 3 Control
0.792
6.7923E−03

TABLE 22

Diagnostic Down

Gene
Public

Fold

ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Change
P value

1
4250
Entrez Gene
secretoglobin, family 2A, member 2
36329_at
Day 3 Intra/Day 3 Extra
0.023
2.7212E−03

3
10647
Entrez Gene
secretoglobin, family 1D, member 2
32880_at
Day 3 Intra/Day 3 Extra
0.102
5.4085E−03

4
HG1763-
The Institute
—
325_s_at
Day 3 Intra/Day 3 Extra
0.038
6.4653E−03

HT178
for Genomic

Research

5
2167
Entrez Gene
fatty acid binding protein 4, adipocyte
38430_at
Day 7 Intra/Day 7 Extra
0.053
1.3371E−03

7
6288
Entrez Gene
serum amyloid A1
33272_at
Day 3 Intra/Day 3 Extra
0.069
6.8147E−03

33272_at
Day 7 Intra/Day 7 Extra
0.117
4.3324E−03

10
1690
Entrez Gene
coagulation factor C homolog, cochlin (Limulus
34190_at
Day 3 Intra/Day 3 Extra
0.129
1.6089E−03

polyphemus)

26
5271
Entrez Gene
serpin peptidase inhibitor, clade B (ovalbumin),
36312_at
Day 7 Intra/Day 7 Extra
0.482
4.6083E−03

member 8

57
23242
Entrez Gene
cordon-bleu homolog (mouse)
35669_at
Day 3 Intra/Day 3 Extra
0.522
4.0595E−04

69
13
Entrez Gene
arylacetamide deacetylase (esterase)
36512_at
Day 3 Intra/Day 3 Extra
0.434
1.5905E−04

75
26
Entrez Gene
amiloride binding protein 1 (amine oxidase
37186_s_at
Day 3 Intra/Day 3 Extra
0.443
5.1668E−03

(copper-containing))

80
26154
Entrez Gene
ATP-binding cassette, sub-family A
31754_at
Day 3 Intra/Day 3 Extra
0.557
5.7474E−03

(ABC1), member 12

82
1410
Entrez Gene
crystallin, alpha B
32243_g_at
Day 3 Intra/Day 3 Extra
0.468
5.9480E−03

84
10733
Entrez Gene
polo-like kinase 4 (Drosophila)
975_at
Day 7 Intra/Day 7 Extra
0.455
5.4588E−03

133
3422
Entrez Gene
isopentenyl-diphosphate delta isomerase 1
36985_at
Day 7 Intra/Day 7 Extra
0.515
5.4407E−03

147
2110
Entrez Gene
electron-transferring-flavoprotein dehydrogenase
33494_at
Day 7 Intra/Day 7 Extra
0.523
1.1689E−03

159
5110
Entrez Gene
Protein-L-isoaspartate (D-aspartate) O-
37737_at
Day 7 Intra/Day 7 Extra
0.534
2.8151E−03

methyltransferase

166
10653
Entrez Gene
serine peptidase inhibitor, Kunitz type, 2
34348_at
Day 7 Intra/Day 7 Extra
0.699
5.3002E−03

171
1662
Entrez Gene
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
831_at
Day 7 Intra/Day 7 Extra
0.544
5.2360E−03

176
202
Entrez Gene
absent in melanoma 1
32112_s_at
Day 3 Intra/Day 3 Extra
0.617
9.6499E−03

177
9774
Entrez Gene
BCL2-associated transcription factor 1
38050_at
Day 7 Intra/Day 7 Extra
0.547
4.7061E−03

181
4232
Entrez Gene
mesoderm specific transcript homolog (mouse)
37749_at
Day 7 Intra/Day 7 Extra
0.553
9.8929E−04

189
10300
Entrez Gene
katanin p80 (WD repeat containing) subunit B1
40976_at
Day 3 Intra/Day 3 Extra
0.559
9.1699E−03

190
55651
Entrez Gene
nucleolar protein family A, member 2
41322_s_at
Day 3 Intra/Day 3 Extra
0.675
9.6475E−03

(H/ACA small nucleolar RNPs)

200
8349
Entrez Gene
histone 2, H2be
33352_at
Day 3 Intra/Day 3 Extra
0.617
5.0561E−03

201
171546
Entrez Gene
chromosome 14 open reading frame 147
33399_at
Day 3 Intra/Day 3 Extra
0.656
8.8383E−03

214
11066
Entrez Gene
U11/U12 snRNP 35K
41029_at
Day 3 Intra/Day 3 Extra
0.589
7.2521E−03

221
5917
Entrez Gene
arginyl-tRNA synthetase
549_at
Day 7 Intra/Day 7 Extra
0.584
6.5983E−03

249
545
Entrez Gene
ataxia telangiectasia and Rad3 related
37229_at
Day 7 Intra/Day 7 Extra
0.597
5.6822E−03

251
8776
Entrez Gene
myotubularin related protein 1
34654_at
Day 3 Intra/Day 3 Extra
0.598
1.6699E−03

255
23234
Entrez Gene
DnaJ (Hsp40) homolog, subfamily C, member 9
41569_at
Day 7 Intra/Day 7 Extra
0.615
8.2268E−03

263
6427
Entrez Gene
splicing factor, arginine/serine-rich 2
36111_s_at
Day 7 Intra/Day 7 Extra
0.665
1.5173E−04

270
3301
Entrez Gene
DnaJ (Hsp40) homolog, subfamily A, member 1
39118_at
Day 7 Intra/Day 7 Extra
0.611
5.7425E−03

289
9
Entrez Gene
N-acetyltransferase 1 (arylamine
38187_at
Day 7 Intra/Day 7 Extra
0.619
5.7524E−03

N-acetyltransferase)

297
8888
Entrez Gene
MCM3 minichromosome maintenance
40469_at
Day 7 Intra/Day 7 Extra
0.624
4.8160E−03

deficient 3 (S. cerevisiae) associated protein

315
8930
Entrez Gene
methyl-CpG binding domain protein 4
34386_at
Day 7 Intra/Day 7 Extra
0.634
3.7388E−03

324
1340
Entrez Gene
cytochrome c oxidase subunit Vib polypeptide 1
40872_at
Day 3 Intra/Day 3 Extra
0.698
6.3894E−03

(ubiquitous)

337
27067
Entrez Gene
staufen, RNA binding protein, homolog 2
38341_at
Day 3 Intra/Day 3 Extra
0.645
8.2036E−03

(Drosophila)

342
1054
Entrez Gene
CCAAT/enhancer binding protein (C/EBP),
39219_at
Day 7 Intra/Day 7 Extra
0.676
1.0916E−03

gamma

352
8732
Entrez Gene
RNA guanylyltransferase and 5′-phosphatase
35202_at
Day 7 Intra/Day 7 Extra
0.654
1.2688E−03

356
51567
Entrez Gene
TRAF and TNF receptor associated protein
34825_at
Day 3 Intra/Day 3 Extra
0.655
3.0500E−05

365
6635
Entrez Gene
small nuclear ribonucleoprotein polypeptide E
38679_g_at
Day 7 Intra/Day 7 Extra
0.661
3.7759E−04

369
7004
Entrez Gene
TEA domain family member 4
41037_at
Day 7 Intra/Day 7 Extra
0.710
7.7243E−03

372
10557
Entrez Gene
ribonuclease P/MRP 38 kDa subunit
41040_at
Day 7 Intra/Day 7 Extra
0.667
4.5174E−03

377
56339
Entrez Gene
Methyltransferase like 3
32244_at
Day 3 Intra/Day 3 Extra
0.726
7.6780E−03

382
10038
Entrez Gene
poly (ADP-ribose) polymerase family, member 2
34756_g_at
Day 7 Intra/Day 7 Extra
0.669
7.1429E−03

387
7411
Entrez Gene
von Hippel-Lindau binding protein 1
171_at
Day 7 Intra/Day 7 Extra
0.672
7.7370E−03

393
25972
Entrez Gene
unc-50 homolog (C. elegans)
39442_at
Day 7 Intra/Day 7 Extra
0.675
9.6835E−03

400
3156
Entrez Gene
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
39328_at
Day 3 Intra/Day 3 Extra
0.681
6.1525E−03

405
2961
Entrez Gene
general transcription factor IIE, polypeptide 2, beta
37295_at
Day 7 Intra/Day 7 Extra
0.796
1.4862E−03

34 kDa

409
4170
Entrez Gene
myeloid cell leukemia sequence 1 (BCL2-related)
277_at
Day 3 Intra/Day 3 Extra
0.684
9.6905E−03

418
4676
Entrez Gene
nucleosome assembly protein 1-like 4
32575_at
Day 7 Intra/Day 7 Extra
0.790
4.9890E−03

444
2926
Entrez Gene
G-rich RNA sequence binding factor 1
32595_at
Day 7 Intra/Day 7 Extra
0.696
6.0979E−03

450
10329
Entrez Gene
transmembrane protein 5
37445_at
Day 3 Intra/Day 3 Extra
0.700
2.4850E−03

453
10542
Entrez Gene
hepatitis B virus x interacting protein
38054_at
Day 7 Intra/Day 7 Extra
0.782
3.3831E−03

456
5431
Entrez Gene
polymerase (RNA) II (DNA directed)
39746_at
Day 7 Intra/Day 7 Extra
0.705
2.3347E−03

polypeptide B, 140 kDa

468
51020
Entrez Gene
HD domain containing 2
34359_at
Day 7 Intra/Day 7 Extra
0.777
2.8509E−03

479
10611
Entrez Gene
PDZ and LIM domain 5
37366_at
Day 3 Intra/Day 3 Extra
0.722
2.3752E−03

489
26100
Entrez Gene
WIPI49-like protein 2
33392_at
Day 3 Intra/Day 3 Extra
0.731
6.9435E−03

509
51304
Entrez Gene
zinc finger, DHHC-type containing 3
39751_at
Day 3 Intra/Day 3 Extra
0.744
7.7468E−03

513
10541
Entrez Gene
acidic (leucine-rich) nuclear phosphoprotein
38479_at
Day 7 Intra/Day 7 Extra
0.747
1.6161E−03

32 family, member B

515
23379
Entrez Gene
KIAA0947 protein
41595_at
Day 7 Intra/Day 7 Extra
0.751
2.7370E−03

548
5636
Entrez Gene
phosphoribosyl pyrophosphate synthetase-
41853_at
Day 3 Intra/Day 3 Extra
0.772
9.6928E−03

associated protein 2

554
10556
Entrez Gene
ribonuclease P/MRP 30 kDa subunit
39702_at
Day 3 Intra/Day 3 Extra
0.778
8.7433E−03

555
9562
Entrez Gene
multiple inositol polyphosphate histidine
38325_at
Day 3 Intra/Day 3 Extra
0.779
8.9541E−03

phosphatase, 1

574
79073
Entrez Gene
hypothetical protein MGC5508
39693_at
Day 3 Intra/Day 3 Extra
0.797
7.6719E−03

589
25966
Entrez Gene
chromosome 21 open reading frame 25
32107_at
Day 7 Intra/Day 7 Extra
0.845
5.8404E−03

TABLE 23

Diagnostic Down

Gene
Public

Fold

ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Change
P value

166
10653
Entrez Gene
serine peptidase inhibitor, Kunitz type, 2
34348_at
Day 7 Intra/Day 7 Extra
0.699
5.3002E−03

TABLE 24

Diagnostic Down

Gene
Public

Fold

ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Change
P value

6
3283
Entrez Gene
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
35721_at
Day 0 Intra/Day 0 Peri
0.062
4.4497E−03

steroid delta-isomerase 1
32190_at
Day 0 Intra/Day 0 Peri
0.081
5.6381E−04

32190_at
Day 7 Intra/Day 7 Peri
0.201
7.6424E−03

9
247
Entrez Gene
arachidonate 15-lipoxygenase, second type
37430_at
Day 0 Intra/Day 0 Peri
0.096
4.5492E−03

12
HG371-
The Institute
—
700_s_at
Day 0 Intra/Day 0 Peri
0.143
4.4849E−03

HT2638
for Genomic

Research

16
L09190
GenBank
Full-length cDNA clone CS0DI027YJ05 of Placenta
37635_at
Day 3 Intra/Day 3 Peri
0.206
2.8404E−03

Cot 25-normalized of Homo sapiens (human)

19
10351
Entrez Gene
ATP-binding cassette, sub-family A (ABC1),
35717_at
Day 3 Intra/Day 3 Peri
0.305
5.8783E−04

member 8

30
3885
Entrez Gene
keratin, hair, acidic, 4
34012_at
Day 0 Intra/Day 0 Peri
0.352
4.5590E−03

44
2194
Entrez Gene
fatty acid synthase
38429_at
Day 0 Intra/Day 0 Peri
0.386
9.3714E−03

68
1117
Entrez Gene
chitinase 3-like 2
31891_at
Day 0 Intra/Day 0 Pari
0.432
5.3219E−04

73
57798
Entrez Gene
GATA zinc finger domain containing 1
34195_at
Day 3 Intra/Day 3 Peri
0.441
6.2766E−04

89
60481
Entrez Gene
ELOVL family member 5, elongation of long chain
33821_at
Day 0 Intra/Day 0 Peri
0.468
8.7794E−03

fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)

92
1545
Entrez Gene
cytochrome P450, family 1, subfamily B,
40071_at
Day 7 Intra/Day 7 Peri
0.471
9.8480E−03

polypeptide 1

105
9987
Entrez Gene
Heterogeneous nuclear ribonucleoprotein D-like
32393_s_at
Day 3 Intra/Day 3 Peri
0.489
1.9407E−03

107
4163
Entrez Gene
mutated in colorectal cancers
35561_at
Day 0 Intra/Day 0 Peri
0.489
6.2800E−05

119
6662
Entrez Gene
SRY (sex determining region Y)-box 9 (campomelic
33436_at
Day 0 Intra/Day 0 Peri
0.521
8.5777E−03

dysplasia, autosomal sex-reversal)

125
51710
Entrez Gene
zinc finger protein 44 (KOX 7)
35409_r_at
Day 3 Intra/Day 3 Peri
0.507
5.1572E−03

126
2533
Entrez Gene
FYN binding protein (FYB-120/130)
41819_at
Day 3 Intra/Day 3 Peri
0.507
3.0115E−03

127
9857
Entrez Gene
centrosome-associated protein 350
33805_at
Day 3 Intra/Day 3 Peri
0.508
4.3400E−05

134
7728
Entrez Gene
zinc finger protein 175
37500_at
Day 7 Intra/Day 7 Peri
0.515
4.1955E−03

153
9140
Entrez Gene
ATG12 autophagy related 12 homolog (S. cerevisiae)
32720_at
Day 3 Intra/Day 3 Peri
0.530
2.7861E−04

163
51099
Entrez Gene
Abhydrolase domain containing 5
33309_at
Day 3 Intra/Day 3 Peri
0.536
9.8735E−03

164
114882
Entrez Gene
oxysterol binding protein-like 8
41438_at
Day 3 Intra/Day 3 Peri
0.536
3.0621E−03

172
5130
Entrez Gene
phosphate cytidylyltransferase 1, choline, alpha
39285_at
Day 0 Intra/Day 0 Peri
0.545
2.3355E−03

174
26235
Entrez Gene
F-box and leucine-rich repeat protein 4
39987_at
Day 7 Intra/Day 7 Peri
0.546
3.2958E−03

184
U73737
GenBank
—
1017_at
Day 3 Intra/Day 3 Peri
0.556
4.6650E−03

211
8315
Entrez Gene
BRCA1 associated protein
41512_at
Day 3 Intra/Day 3 Peri
0.677
7.0812E−04

219
65055
Entrez Gene
chromosome 2 open reading frame 23
36096_at
Day 3 Intra/Day 3 Peri
0.583
2.9762E−03

225
5927
Entrez Gene
Jumonji, AT rich interactive domain 1A
1785_at
Day 3 Intra/Day 3 Peri
0.585
3.1353E−03

(RBBP2-like)

226
2824
Entrez Gene
glycoprotein M6B
37251_s_at
Day 3 Intra/Day 3 Peri
0.586
8.6602E−03

247
2355
Entrez Gene
FOS-like antigen 2
40268_at
Day 0 Intra/Day 0 Peri
0.596
5.8255E−03

261
6651
Entrez Gene
SON DNA binding protein
39096_at
Day 7 Intra/Day 7 Peri
0.641
4.2992E−03

273
23090
Entrez Gene
zinc finger protein 423
34950_at
Day 7 Intra/Day 7 Peri
0.623
7.6235E−03

288
3418
Entrez Gene
isocitrate dehydrogenase 2 (NADP+), mitochondrial
32332_at
Day 0 Intra/Day 0 Peri
0.617
1.2980E−03

302
24139
Entrez Gene
echinoderm microtubule associated protein like 2
41328_s_at
Day 0 Intra/Day 0 Peri
0.627
4.4037E−03

311
4681
Entrez Gene
neuroblastoma, suppression of tumorigenicity 1
37005_at
Day 0 Intra/Day 0 Peri
0.631
3.2813E−03

329
4026
Entrez Gene
LIM domain containing preferred translocation
41195_at
Day 3 Intra/Day 3 Peri
0.639
3.3595E−03

partner in lipoma

369
7004
Entrez Gene
TEA domain family member 4
41037_at
Day 0 Intra/Day 0 Peri
0.755
4.0427E−03

399
50813
Entrez Gene
COP9 constitutive photomorphogenic homolog
34404_at
Day 0 Intra/Day 0 Peri
0.681
4.7805E−03

subunit 7A (Arabidopsis)

414
23112
Entrez Gene
trinucleotide repeat containing 6B
37487_at
Day 3 Intra/Day 3 Peri
0.688
3.9849E−03

435
889
Entrez Gene
KRIT1, ankyrin repeat containing
34031_i_at
Day 3 Intra/Day 3 Peri
0.694
4.9207E−03

464
22882
Entrez Gene
zinc fingers and homeoboxes 2
41503_at
Day 7 Intra/Day 7 Peri
0.750
6.4066E−03

473
3054
Entrez Gene
host cell factor C1 (VP16-accessory protein)
37910_at
Day 0 Intra/Day 0 Peri
0.718
6.3341E−03

494
10075
Entrez Gene
HECT, UBA and WWE domain containing 1
34374_g_at
Day 0 Intra/Day 0 Peri
0.733
2.9867E−03

550
9703
Entrez Gene
KIAA0100 gene product
39783_at
Day 0 Intra/Day 0 Peri
0.773
4.2046E−03

557
5326
Entrez Gene
pleiomorphic adenoma gene-like 2
40061_at
Day 3 Intra/Day 3 Peri
0.779
7.8774E−03

TABLE 25

Diagnostic Down

Public

Fold

Gene ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Change
P value

329
4026
Entrez Gene
LIM domain containing preferred
41195_at
Day 3 Intra/Day 3 Peri
0.639
3.3595E−03

translocation partner in lipoma

TABLE 26

Diagnostic Down

Gene
Public

Fold

ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Change
P value

13
125
Entrez Gene
alcohol dehydrogenase IB (class I), beta
35730_at
Day 3 Intra/Day 0 Intra
0.162
9.2302E−03

polypeptide

18
7123
Entrez Gene
C-type lectin domain family 3, member B
36569_at
Day 3 Intra/Day 0 Intra
0.243
7.7786E−03

19
10351
Entrez Gene
ATP-binding cassette, sub-family A (ABC1),
35717_at
Day 3 Intra/Day 0 Intra
0.279
3.1166E−03

member 8

20
AB011538
GenBank
CDNA clone IMAGE: 5922621
35324_at
Day 3 Intra/Day 0 Intra
0.280
3.8006E−03

21
3131
Entrez Gene
Hepatic leukemia factor
38627_at
Day 3 Intra/Day 0 Intra
0.289
1.1838E−03

38627_at
Day 7 Intra/Day 0 Intra
0.325
6.7101E−03

23
4211
Entrez Gene
Meis1, myeloid ecotropic viral integration site 1
40763_at
Day 3 Intra/Day 0 Intra
0.324
4.5206E−03

homolog (mouse)

24
2053
Entrez Gene
epoxide hydrolase 2, cytoplasmic
41473_at
Day 3 Intra/Day 0 Intra
0.327
3.5922E−03

25
4253
Entrez Gene
CTAGE family, member 5
41615_at
Day 3 Intra/Day 0 Intra
0.330
3.8948E−03

32
11075
Entrez Gene
stathmin-like 2
38800_at
Day 3 Intra/Day 0 Intra
0.356
5.6882E−03

33
3075
Entrez Gene
complement factor H
32250_at
Day 7 Intra/Day 0 Intra
0.356
2.4648E−03

34
10458
Entrez Gene
BAI1-associated protein 2
37760_at
Day 7 Intra/Day 3 Intra
0.799
8.1747E−03

35
9086
Entrez Gene
eukaryotic translation initiation factor 1A, Y-linked
40097_at
Day 3 Intra/Day 0 Intra
0.358
8.6154E−03

36
2273
Entrez Gene
four and a half LIM domains 1
32542_at
Day 3 Intra/Day 0 Intra
0.367
5.7500E−03

40
4223
Entrez Gene
mesenchyme homeo box 2 (growth arrest-specific
40398_s_at
Day 3 Intra/Day 0 Intra
0.376
7.2046E−03

homeo box)

41
3400
Entrez Gene
inhibitor of DNA binding 4, dominant negative
41536_at
Day 3 Intra/Day 0 Intra
0.381
8.0900E−05

helix-loop-helix protein
41536_at
Day 7 Intra/Day 0 Intra
0.410
2.1354E−03

48
9452
Entrez Gene
integral membrane protein 2A
40775_at
Day 3 Intra/Day 0 Intra
0.392
3.3491E−03

40775_at
Day 7 Intra/Day 0 Intra
0.400
2.0273E−03

51
5354
Entrez Gene
proteolipid protein 1 (Pelizaeus-Merzbacher
41158_at
Day 3 Intra/Day 0 Intra
0.403
1.1357E−04

disease, spastic paraplegia 2, uncomplicated)
41158_at
Day 7 Intra/Day 0 Intra
0.503
1.7500E−03

54
224
Entrez Gene
aldehyde dehydrogenase 3 family, member A2
40409_at
Day 3 Intra/Day 0 Intra
0.466
8.5061E−04

57
23242
Entrez Gene
cordon-bleu homolog (mouse)
35669_at
Day 3 Intra/Day 0 Intra
0.414
5.3389E−03

61
M11119
GenBank
—
38850_at
Day 3 Intra/Day 0 Intra
0.428
8.8745E−03

62
9687
Entrez Gene
GREB1 protein
38875_r_at
Day 7 Intra/Day 0 Intra
0.428
1.0961E−04

63
51097
Entrez Gene
saccharopine dehydrogenase (putative)
34862_at
Day 7 Intra/Day 0 Intra
0.680
6.5823E−03

67
9145
Entrez Gene
synaptogyrin 1
35354_at
Day 7 Intra/Day 0 Intra
0.432
1.9735E−03

35354_at
Day 3 Intra/Day 0 Intra
0.469
5.7597E−03

76
AL080082
GenBank
MRNA; cDNA DKFZp564G1162 (from clone
35581_at
Day 3 Intra/Day 0 Intra
0.444
9.2254E−03

DKFZp564G1162)

85
8848
Entrez Gene
TSC22 domain family, member 1
39032_at
Day 3 Intra/Day 0 Intra
0.455
1.8273E−03

87
5264
Entrez Gene
phytanoyl-CoA hydroxylase (Refsum disease)
32724_at
Day 3 Intra/Day 0 Intra
0.465
4.1244E−03

91
10248
Entrez Gene
processing of precursor 7, ribonuclease P subunit
32213_at
Day 7 Intra/Day 3 Intra
0.470
9.0083E−03

(S. cerevisiae)

96
10090
Entrez Gene
uronyl-2-sulfotransferase
41859_at
Day 3 Intra/Day 0 Intra
0.474
1.8927E−03

41859_at
Day 7 Intra/Day 0 Intra
0.521
1.4198E−04

98
352961
Entrez Gene
MHC class I mRNA fragment 3.8-1
34934_at
Day 3 Intra/Day 0 Intra
0.479
6.5297E−03

100
10628
Entrez Gene
thioredoxin interacting protein
31508_at
Day 3 Intra/Day 0 Intra
0.482
9.0159E−03

102
6038
Entrez Gene
ribonuclease, RNase A family, 4
32664_at
Day 3 Intra/Day 0 Intra
0.483
2.7472E−03

32664_at
Day 7 Intra/Day 0 Intra
0.569
4.9291E−04

104
6414
Entrez Gene
selenoprotein P, plasma, 1
34363_at
Day 3 Intra/Day 0 Intra
0.488
6.0330E−03

111
2947
Entrez Gene
glutathione S-transferase M3 (brain)
1120_at
Day 7 Intra/Day 0 Intra
0.494
7.1503E−03

114
8864
Entrez Gene
period homolog 2 (Drosophila)
35008_at
Day 3 Intra/Day 0 Intra
0.497
4.3990E−03

117
104
Entrez Gene
adenosine deaminase, RNA-specific, B1 (RED1
38748_at
Day 3 Intra/Day 0 Intra
0.499
8.5077E−04

homolog rat)
38748_at
Day 7 Intra/Day 0 Intra
0.541
1.9004E−03

122
9831
Entrez Gene
zinc finger protein 623
39954_r_at
Day 3 Intra/Day 0 Intra
0.505
3.3609E−03

124
22982
Entrez Gene
KIAA0934
33408_at
Day 3 Intra/Day 0 Intra
0.506
3.1621E−03

128
9891
Entrez Gene
NUAK family, SNF1-like kinase, 1
33787_at
Day 3 Intra/Day 0 Intra
0.508
1.4528E−03

131
23051
Entrez Gene
zinc fingers and homeoboxes 3
40461_at
Day 3 Intra/Day 0 Intra
0.513
6.7006E−04

40461_at
Day 7 Intra/Day 0 Intra
0.609
6.3269E−03

140
10284
Entrez Gene
Sin3-associated polypeptide, 18 kDa
41217_at
Day 3 Intra/Day 0 Intra
0.520
2.4318E−03

143
7073
Entrez Gene
TIA1 cytotoxic granule-associated RNA binding
41761_at
Day 3 Intra/Day 0 Intra
0.521
4.5836E−03

protein-like 1

145
8853
Entrez Gene
development and differentiation enhancing factor 2
39410_at
Day 7 Intra/Day 0 Intra
0.521
2.9990E−03

146
4968
Entrez Gene
8-oxoguanine DNA glycosylase
38335_at
Day 3 Intra/Day 0 Intra
0.522
7.5868E−04

38335_at
Day 7 Intra/Day 0 Intra
0.626
6.6349E−03

151
55187
Entrez Gene
vacuolar protein sorting 13D (yeast)
32743_at
Day 3 Intra/Day 0 Intra
0.527
2.5585E−03

155
23506
Entrez Gene
KIAA0240
38892_at
Day 3 Intra/Day 0 Intra
0.531
5.3954E−03

158
6595
Entrez Gene
SWI/SNF related, matrix associated, actin
40961_at
Day 3 Intra/Day 0 Intra
0.533
6.2437E−03

dependent regulator of chromatin, subfamily a,

member 2

161
201229
Entrez Gene
hypothetical protein LOC201229
39557_at
Day 3 Intra/Day 0 Intra
0.535
2.3943E−03

162
22909
Entrez Gene
KIAA1018 protein
36458_at
Day 3 Intra/Day 0 Intra
0.536
6.1234E−03

168
399563
Entrez Gene
hypothetical protein FLJ43806
37151_at
Day 7 Intra/Day 0 Intra
0.542
7.7014E−03

182
2145
Entrez Gene
enhancer of zeste homolog 1 (Drosophila)
32259_at
Day 7 Intra/Day 0 Intra
0.554
8.0450E−03

196
57209
Entrez Gene
zinc finger protein 248
35139_at
Day 3 Intra/Day 0 Intra
0.565
2.1978E−03

211
8315
Entrez Gene
BRCA1 associated protein
41512_at
Day 3 Intra/Day 0 Intra
0.577
1.1128E−03

212
8623
Entrez Gene
acetylserotonin O-methyltransferase-like
36553_at
Day 3 Intra/Day 0 Intra
0.578
7.1773E−04

213
169611
Entrez Gene
olfactomedin-like 2A
38312_at
Day 3 Intra/Day 0 Intra
0.579
3.6248E−03

218
128
Entrez Gene
alcohol dehydrogenase 5 (class III), chi polypeptide
37708_r_at
Day 3 Intra/Day 0 Intra
0.582
8.9780E−03

223
2621
Entrez Gene
growth arrest-specific 6
1597_at
Day 3 Intra/Day 0 Intra
0.585
6.6299E−03

224
831
Entrez Gene
calpastatin
41257_at
Day 3 Intra/Day 0 Intra
0.585
5.3045E−04

227
1153
Entrez Gene
cold inducible RNA binding protein
39864_at
Day 3 Intra/Day 0 Intra
0.587
2.1268E−03

39864_at
Day 7 Intra/Day 0 Intra
0.611
6.9554E−03

230
AB006780
GenBank
lectin, galactoside-binding, soluble, 3 (galectin 3) ///
35367_at
Day 3 Intra/Day 0 Intra
0.590
8.4864E−03

galectin-3 internal gene

231
6929
Entrez Gene
transcription factor 3 (E2A immunoglobulin
1373_at
Day 3 Intra/Day 0 Intra
0.590
2.7482E−03

enhancer binding factors E12/E47)

242
23353
Entrez Gene
unc-84 homolog A (C. elegans)
36588_at
Day 7 Intra/Day 0 Intra
0.594
2.9354E−03

244
6670
Entrez Gene
Sp3 transcription factor
41573_at
Day 3 Intra/Day 0 Intra
0.594
6.5653E−03

253
AL080234
GenBank
Full-length cDNA clone CS0DM001YA04 of Fetal
38070_at
Day 7 Intra/Day 0 Intra
0.598
4.0826E−03

liver of Homo sapiens (human)

256
94239
Entrez Gene
H2A histone family, member V
39046_at
Day 3 Intra/Day 0 Intra
0.600
7.9321E−03

39046_at
Day 7 Intra/Day 0 Intra
0.650
5.0612E−03

257
AI557912
GenBank
translocase of outer mitochondrial membrane 7
39025_at
Day 7 Intra/Day 0 Intra
0.601
3.8343E−03

homolog (yeast) /// hypothetical protein LOC201725

261
6651
Entrez Gene
SON DNA binding protein
39096_at
Day 7 Intra/Day 0 Intra
0.607
3.4000E−03

39096_at
Day 7 Intra/Day 3 Intra
0.710
4.2168E−03

263
6427
Entrez Gene
splicing factor, arginine/serine-rich 2
36111_s_at
Day 7 Intra/Day 3 Intra
0.709
6.0916E−03

264
221749
Entrez Gene
chromosome 6 open reading frame 145
34246_at
Day 3 Intra/Day 0 Intra
0.608
3.6829E−03

267
54665
Entrez Gene
round spermatid basic protein 1
37828_at
Day 3 Intra/Day 0 Intra
0.610
7.8572E−04

274
64112
Entrez Gene
modulator of apoptosis 1
34767_at
Day 3 Intra/Day 0 Intra
0.614
4.4658E−03

282
23392
Entrez Gene
KIAA0368
34414_at
Day 7 Intra/Day 0 Intra
0.616
1.2883E−03

283
5934
Entrez Gene
retinoblastoma-like 2 (p130)
32597_at
Day 3 Intra/Day 0 Intra
0.616
8.7510E−03

284
4781
Entrez Gene
Nuclear factor I/B
41229_at
Day 3 Intra/Day 0 Intra
0.616
3.0477E−03

290
25797
Entrez Gene
glutaminyl-peptide cyclotransferase (glutaminyl
35966_at
Day 3 Intra/Day 0 Intra
0.619
4.9522E−03

cyclase)

298
10289
Entrez Gene
translation factor sul1 homolog
33351_at
Day 3 Intra/Day 0 Intra
0.673
1.7268E−03

310
22903
Entrez Gene
BTB (POZ) domain containing 3
37755_at
Day 3 Intra/Day 0 Intra
0.631
9.7703E−03

312
10301
Entrez Gene
deleted in lymphocytic leukemia, 1
33791_at
Day 7 Intra/Day 0 Intra
0.631
8.9965E−03

33791_at
Day 3 Intra/Day 0 Intra
0.726
6.7457E−03

313
AF052138
GenBank
FLJ35348 /// Bromodomain containing 3
41841_at
Day 3 Intra/Day 0 Intra
0.632
4.2490E−03

319
1428
Entrez Gene
crystallin, mu
38285_at
Day 3 Intra/Day 0 Intra
0.636
1.2448E−03

320
10614
Entrez Gene
Hexamethylene bis-acetamide inducible 1
40220_at
Day 3 Intra/Day 0 Intra
0.636
3.7740E−03

334
6230
Entrez Gene
ribosomal protein S25
31573_at
Day 7 Intra/Day 0 Intra
0.643
9.4033E−03

341
9521
Entrez Gene
eukaryotic translation elongation factor 1 epsilon 1
40587_s_at
Day 7 Intra/Day 3 Intra
0.647
1.9928E−03

360
3298
Entrez Gene
heat shock transcription factor 2
202_at
Day 7 Intra/Day 0 Intra
0.658
7.1609E−03

363
23384
Entrez Gene
KIAA0376 protein
34837_at
Day 3 Intra/Day 0 Intra
0.659
2.3071E−03

365
6635
Entrez Gene
small nuclear ribonucleoprotein polypeptide E
38679_g_at
Day 7 Intra/Day 3 Intra
0.697
1.8800E−05

373
26156
Entrez Gene
ribosomal L1 domain containing 1
39418_at
Day 7 Intra/Day 3 Intra
0.691
5.6288E−03

376
26053
Entrez Gene
autism susceptibility candidate 2
35648_at
Day 3 Intra/Day 0 Intra
0.667
3.9622E−03

377
56339
Entrez Gene
Methyltransferase like 3
32244_at
Day 3 Intra/Day 0 Intra
0.667
8.9345E−04

386
10904
Entrez Gene
bladder cancer associated protein
35267_g_at
Day 7 Intra/Day 0 Intra
0.672
2.1451E−03

390
1349
Entrez Gene
cytochrome c oxidase subunit VIIb
36687_at
Day 7 Intra/Day 3 Intra
0.673
1.8885E−03

391
54462
Entrez Gene
KIAA1128
37617_at
Day 3 Intra/Day 0 Intra
0.674
5.5416E−03

392
80003
Entrez Gene
pecanex-like 2 (Drosophila)
39650_s_at
Day 3 Intra/Day 0 Intra
0.674
6.1109E−03

394
64795
Entrez Gene
hypothetical protein FLJ13910
36580_at
Day 3 Intra/Day 0 Intra
0.676
3.2610E−03

397
7743
Entrez Gene
zinc finger protein 189
36072_at
Day 3 Intra/Day 0 Intra
0.678
3.7246E−03

417
9759
Entrez Gene
histone deacetylase 4
38271_at
Day 3 Intra/Day 0 Intra
0.689
4.9833E−03

422
1749
Entrez Gene
distal-less homeo box 5
41087_at
Day 3 Intra/Day 0 Intra
0.689
3.6526E−03

427
22794
Entrez Gene
cancer susceptibility candidate 3
38437_at
Day 7 Intra/Day 0 Intra
0.692
2.7057E−03

38437_at
Day 3 Intra/Day 0 Intra
0.742
4.1247E−03

428
322
Entrez Gene
amyloid beta (A4) precursor protein-binding, family
1101_at
Day 7 Intra/Day 0 Intra
0.692
1.6594E−03

B, member 1 (Fe65)

430
6637
Entrez Gene
small nuclear ribonucleoprotein polypeptide G
37337_at
Day 7 Intra/Day 3 Intra
0.693
3.9690E−03

439
2549
Entrez Gene
GRB2-associated binding protein 1
33997_at
Day 7 Intra/Day 0 Intra
0.695
2.4091E−04

33997_at
Day 3 Intra/Day 0 Intra
0.710
2.0825E−03

443
23125
Entrez Gene
calmodulin binding transcription activator 2
41421_at
Day 7 Intra/Day 0 Intra
0.696
8.6760E−03

447
22849
Entrez Gene
cytoplasmic polyadenylation element binding
34931_at
Day 3 Intra/Day 0 Intra
0.697
6.8691E−03

protein 3

448
10106
Entrez Gene
CTD (carboxy-terminal domain, RNA polymerase
41202_s_at
Day 3 Intra/Day 0 Intra
0.698
3.5449E−03

II, polypeptide A) small phosphatase 2

451
26959
Entrez Gene
HMG-box transcription factor 1
39809_at
Day 3 Intra/Day 0 Intra
0.701
9.4669E−03

454
8624
Entrez Gene
Down syndrome critical region gene 2
36088_at
Day 7 Intra/Day 3 Intra
0.704
8.0554E−03

468
51020
Entrez Gene
HD domain containing 2
34359_at
Day 7 Intra/Day 0 Intra
0.712
2.4876E−03

474
79026
Entrez Gene
AHNAK nucleoprotein (desmoyokin)
37027_at
Day 7 Intra/Day 0 Intra
0.718
8.1471E−03

482
9813
Entrez Gene
KIAA0494
41830_at
Day 3 Intra/Day 0 Intra
0.725
3.4757E−03

500
23259
Entrez Gene
DDHD domain containing 2
35177_at
Day 7 Intra/Day 0 Intra
0.736
6.5771E−03

519
9215
Entrez Gene
like-glycosyltransferase
41346_at
Day 3 Intra/Day 0 Intra
0.754
4.1376E−03

521
10241
Entrez Gene
nuclear domain 10 protein
40063_at
Day 3 Intra/Day 0 Intra
0.755
7.6513E−03

526
1955
Entrez Gene
EGF-like-domain, multiple 5
36488_at
Day 3 Intra/Day 0 Intra
0.759
7.4685E−03

530
4601
Entrez Gene
MAX interactor 1
39072_at
Day 3 Intra/Day 0 Intra
0.762
4.0454E−03

532
1998
Entrez Gene
E74-like factor 2 (ets domain transcription factor)
507_s_at
Day 7 Intra/Day 0 Intra
0.763
4.9954E−03

537
7693
Entrez Gene
zinc finger protein 134 (clone pHZ-15)
36295_at
Day 3 Intra/Day 0 Intra
0.764
9.8397E−03

545
23294
Entrez Gene
ankyrin repeat and sterile alpha motif domain
40971_at
Day 3 Intra/Day 0 Intra
0.769
7.4093E−03

containing 1

551
10294
Entrez Gene
DnaJ (Hsp40) homolog, subfamily A, member 2
34201_at
Day 3 Intra/Day 0 Intra
0.775
2.1191E−03

552
9741
Entrez Gene
lysosomal-associated protein transmembrane 4
39019_at
Day 3 Intra/Day 0 Intra
0.776
6.0768E−03

alpha
39019_at
Day 7 Intra/Day 0 Intra
0.815
9.6992E−03

556
9528
Entrez Gene
transmembrane protein 59
39033_at
Day 3 Intra/Day 0 Intra
0.787
2.6172E−04

564
51780
Entrez Gene
Jumonji domain containing 1B
33870_at
Day 3 Intra/Day 0 Intra
0.789
6.0617E−03

587
369
Entrez Gene
v-raf murine sarcoma 3611 viral oncogene homolog
1706_at
Day 7 Intra/Day 3 Intra
0.832
4.3502E−04

588
23
Entrez Gene
ATP-binding cassette, sub-family F (GCN20),
39141_at
Day 7 Intra/Day 3 Intra
0.837
5.3611E−03

member 1

590
23644
Entrez Gene
autoantigen
36670_at
Day 3 Intra/Day 0 Intra
0.866
7.3351E−03

TABLE 27

Diagnostic Down

Gene
Public

Fold

ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Change
P value

24
2053
Entrez Gene
epoxide hydrolase 2, cytoplasmic
41473_at
Day 3 Intra/Day 0 Intra
0.327
3.5922E−03

417
9759
Entrez Gene
histone deacetylase 4
38271_at
Day 3 Intra/Day 0 Intra
0.689
4.9833E−03

588
23
Entrez Gene
ATP-binding cassette, sub-family F
39141_at
Day 7 Intra/Day 3 Intra
0.837
5.3611E−03

(GCN20), member 1

TABLE 28

Diagnostic Down

Public

Gene ID
Identifier
Data Source
Gene Name
Probe_ID
Comparison
Fold Change
P value

102
6038
Entrez Gene
ribonuclease, RNase A family, 4
32664_at
Day 3 Intra/Day 0 Intra
0.483
2.7472E−03

32664_at
Day 7 Intra/Day 0 Intra
0.569
4.9291E−04

METHOD OF DIAGNOSIS

Information

Publication Number

Date Filed

Date Published

Inventors

Original Assignees

CPC

US Classifications

International Classifications

Abstract

Description

Claims

Priority Claims (1)

PCT Information