Claims
- 1. A method of sterilizing articles in a load in a chamber with a chemical sterilant, comprising:a) conditioning the load; b) introducing chemical sterilant; c) maintaining the load with the chemical sterilant to achieve sterilization, wherein conditioning the load comprises steps d) to g);d) evacuating said chamber; e) generating plasma in said chamber; f) venting said chamber to approximately atmospheric or subatmospheric pressure; and g) repeating d) to f) at least two times.
- 2. The method of claim 1, wherein conditioning the load comprises increasing the temperature of at least a portion of the load to at least 30° C.
- 3. The method of claim 1, wherein conditioning the load comprises increasing the temperature of at least a portion of the load to at least 35° C.
- 4. The method of claim 1, wherein said chemical sterilant comprises hydrogen peroxide.
- 5. The method of claim 1, additionally comprising venting said chamber to a pressure, maintaining said pressure, and then evacuating said chamber, wherein said venting is after step c).
- 6. The method of claim 1, wherein step b) or c) additionally comprises generating plasma in said chamber.
- 7. The method of claim 5, wherein the plasma is generated with lower power than the plasma of step e).
- 8. A method of reducing sterilant residuals on articles in a load in a chamber comprising:a) evacuating said chamber a first time; b) introducing sterilant; c) maintaining the load with the sterilant to achieve sterilization; d) venting said chamber to a pressure; e) maintaining said pressure; f) evacuating said chamber a second time; g) venting said chamber a second time; and h) removing said articles in said load from said chamber.
- 9. The method of claim 8, wherein said venting pressure is atmospheric or sub-atmospheric pressure.
- 10. The method of claim 8, additionally comprising generating plasma in said chamber in step b), c) or f).
- 11. The method of claim 8, further comprising repeating steps d) through f).
- 12. The method of claim 8, further comprising:a′) evacuating said chamber; b′) generating plasma in said chamber; and c′) venting said chamber; wherein steps a′) to c′) occur prior to steps a) to h) of claim 8.
- 13. A method for sterilizing devices in a chamber, said method having at least two plasma steps, wherein at least one plasma step occurs before introducing the chemical sterilant and at least one plasma step occurs after introducing said chemical sterilant, comprising:generating plasma with a higher power level in the at least one plasma step occurring before introducing the chemical sterilant than in the at least one plasma step occurring after introducing said chemical sterilant.
- 14. The method of claim 13, wherein said chemical sterilant comprises hydrogen peroxide.
- 15. The method of claim 13, additionally comprising:a) venting said chamber; and b) evacuating said chamber; wherein steps a) and b) occur after generating plasma with the higher power level.
- 16. The method of claim 13, additionally comprising:a) venting said chamber to a pressure; b) maintaining said pressure; and c) evacuating said chamber, wherein steps a) through c) occur after the at least one plasma step occurring after introducing said chemical sterilant.
- 17. A method of sterilizing articles in a load with a chemical sterilant in a chamber with improved material compatibility comprising:a) evacuating the chamber; b) generating plasma with a first power level; c) venting the chamber to a pressure d) evacuating the chamber; e) introducing chemical sterilant into the chamber, wherein said introducing occurs after generating plasma with the first power level; f) evacuating the chamber; g) generating plasma with a second power level, wherein said generating plasma with the second power level occurs after said introducing; h) venting said chamber, wherein said venting occurs after generating plasma with the second power level; i) evacuating said chamber; and j) venting said chamber, wherein said first power level is higher than said second power level, thereby sterilizing said articles with improved material compatibility.
- 18. The method of claim 17, additionally comprising repeating steps a), b) and c) more than once.
- 19. The method of claim 17, additional comprising venting after step e).
- 20. The method of claim 17, additionally comprising maintaining the pressure after venting step h).
- 21. The method of claim 17, additionally comprising generating plasma in said chamber after step i).
- 22. The method of claim 17, additionally comprising repeating steps h) and i).
- 23. The method of claim 17, wherein said chemical sterilant comprises an antimicrobial agent.
- 24. The method of claim 23, wherein said antimicrobial agent comprises hydrogen peroxide.
RELATED APPLICATIONS
This application claims the benefits under 35 U.S.C. §119(e) of Provisional Application No. 60/127,160, filed Mar. 31, 1999.
US Referenced Citations (16)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0 707 186 |
Apr 1996 |
EP |
Non-Patent Literature Citations (1)
Entry |
A New Technology for Instrument Sterilization, Advanced Sterilization Products, Paul T. Jacobs, 1993. |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/127160 |
Mar 1999 |
US |