Patent Grant
7013617
The present invention relates to a method of filling and sealing a gas capsule, particularly a gas capsule of a kind that holds a discrete volume of pressurised gas at high pressure, say, between 30 bar and 80 bar.
Sealed gas capsules are well known for use in circumstances where the force of the gas, typically carbon dioxide, under pressure is employed to dispense a substance such as draught beer from a beer dispenser or soda water from a soda siphon. Such capsules have a body portion and a neck portion, the latter typically being provided with a seal which is able to be broken so as to release the gas.
It is also known to employ such sealed gas capsules containing helium at high pressures in medical devices using the energy of the pressurised helium to drive a therapeutic agent through the skin of a patient. The storage of helium presents particular problems in view of its high fugacity.
In PCT published application WO94/24263 there is described a needle-less syringe, which includes a metal capsule containing helium gas at high pressure which is used to force particles of a therapeutic agent through the skin of a patient in a substantially painless manner. The capsule is detachable from the remainder of the syringe and once used, either a new charge of gas can be placed in the capsule or more favourably the capsule can be discarded and a new capsule charged with gas can be attached to the remainder of the syringe.
In the circumstance where the gas capsule is a “throw away” item it is important that it can be manufactured simply and cheaply. In medical applications helium gas is a favoured fluid since it is very light which makes it suitable for use as a propellant for therapeutic agents in that when it impinges against the skin of a patient it will bounce off into the atmosphere and not pass through the skin of the patient. However, helium because it is light, is difficult to contain since it will leak through the most minuscule fault in a container.
U.S. Pat. No. 4,727,233 relates to the sealing of metal tubes, particularly of stainless steel, for example, tubes that are used to fill containers of gas at high pressure. In the method according to U.S. Pat. No. 4,727,233, once a predetermined quantity of gas has been supplied to the container, the latter is sealed by the cutting and sealing of the tube through which it is filled. The following procedure is adopted. A pair of main jaws which carry so-called presser nibs are operated to squash part a chosen portion of the tube. A pair of auxiliary jaws which also carry presser nibs are detachably engaged to the main jaws. Accordingly, operation of the main jaws causes the auxiliary jaws to squash the rest of the chosen portion of the tube. The squashing of the chosen portion of the tube is carried out in such a manner so as to achieve a completely sealed constriction of the tube. If desired, a bush may be pre-inserted in the chosen portion of the tube so as to facilitate the formation of this seal. The auxiliary jaws are then disengaged from the main jaws and taken away so as to free part of the squashed part of the tube, while the remaining part of the squashed portion remains under the clamping pressure exerted by the main jaws. The tube is then severed, for example, by means of cutting blades, at the freed part of the squashed portion to form an end having lips. The lips are then welded, for example, by plasma-arc welding.
The procedure set out in U.S. Pat. No. 4,727,233 has a number of disadvantages. First, the need to disengage the auxiliary jaws from the main jaws and then to sever the tube adds considerably to the length of time required to perform the entire sealing operation and therefore makes it unsuitable for use in industrial production when the tubes are required on a continuous basis. Second, the cutting of the tube may create small particles of metal that may interfere with the subsequent welding process or even become trapped in the lips making possible their subsequent release under pressure if the sealed gas container is to be opened by puncturing the weld. Such release of metal particles could be injurious to a patient if the gas is employed for the transcutaneous delivery of a pharmaceutical.
It is an aim of the present invention to provide a method of filling and sealing a gas capsule with helium at a pressure of at least 30 bar.
According to the present invention, a method of filling and sealing a gas capsule having (i) a hollow body portion and (ii) an elongate hollow neck portion having a free open distal end extending from the body portion, comprising the sequential steps of:
Preferably the fluid is helium at a pressure of at least 30 bar, and the capsule is formed of aluminium or an aluminium alloy.
An embodiment of the invention will now be described by way of example, reference being made to the Figures of the accompanying diagrammatic drawing in which;
As shown, a capsule 1 comprises a hollow cylindrical body portion 2 made, for example, from aluminium or an aluminium alloy from which extends an elongate hollow neck portion 4 of smaller diameter than the body portion 2. Initially the neck portion 4 has an open free distal end 6.
When it is desired to fill the capsule 1 with helium under pressure, a filling cap 7 is applied in a manner known per se to the free distal end 6 of the neck portion 4. A vacuum is applied at the filling cap 7 to evacuate the hollow cylinder body portion 2 after which the body portion 2 is filled with the helium under pressure. With the filling cap 7 still in place over the free distal end of the neck portion 4 and pressure still applied to the fluid within the body portion 2, the elongate hollow neck portion 4 is crimped at a location spaced from said free end 6 (see FIG. 2). This crimp is made sufficiently firm to avoid significant leakage of fluid from the body portion 2.
The filling cap 7 is then removed from the free distal end 6 of the neck portion 4 to reveal said free distal end 6. Immediately said free end 6 is revealed then a second crimp is applied (see
The purpose of the first crimp is to prevent fluid under pressure from reaching the second crimp and thus the free distal end 6 so that the laser weld can be made without gas permeation holes. Effectively, the two crimps define an interim chamber which prevents or inhibits fluid under pressure reaching the point where the free distal end 6 of the neck portion 4 is to be welded.
The crimps can be effected with either a circular swage type crimp or a simple flat crimp.
When the capsule is to be used in connection with a needleless syringe then the fluid will be helium at a pressure of at least 30 bar.
The method according to the invention enables the weld to be made at the distal free end 7 of the elongate hollow neck portion 4. In consequence, no severing of the neck portion 4 is performed at any time during the filling and sealing procedure.
This application is a continuation-in-part of U.S. patent application Ser. No. 09/718,856 filed Nov. 22, 2000, now abandoned which application is a continuation-in-part of U.S. patent application Ser. No. 09/283,551 filed Apr. 1, 1999, now abandoned.
| Number | Name | Date | Kind |
|---|---|---|---|
| 636317 | Von Bühler | Nov 1899 | A |
| 2335799 | Schwab | Nov 1943 | A |
| 2503171 | Posner | Apr 1950 | A |
| 2837880 | Rosenblatt et al. | Jun 1958 | A |
| 3141225 | Watson | Jul 1964 | A |
| 3374126 | Lingenfelter | Mar 1968 | A |
| 3785025 | Wolf | Jan 1974 | A |
| 3789689 | Mace | Feb 1974 | A |
| 4204378 | Thompson | May 1980 | A |
| 4287746 | Thompson | Sep 1981 | A |
| 4727233 | Pavese et al. | Feb 1988 | A |
| 5159799 | Rising et al. | Nov 1992 | A |
| 5221311 | Rising et al. | Jun 1993 | A |
| 5358288 | Lindner et al. | Oct 1994 | A |
| 5546783 | Fischer et al. | Aug 1996 | A |
| Number | Date | Country |
|---|---|---|
| WO 9424263 | Oct 1994 | WO |
| Number | Date | Country | |
|---|---|---|---|
| 20050050849 A1 | Mar 2005 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 09718856 | Nov 2000 | US |
| Child | 10699131 | US | |
| Parent | 09283551 | Apr 1999 | US |
| Child | 09718856 | US |
