Claims
- 1. A kit for qualifying an automated biological screening system, comprising:
at least one slide carrying a biological specimen with a plurality of marked target zones (MTZs) exhibiting an attribute, the at least one slide being configured for being processed by the automated biological screening system to determine locations of biological objects suspected of exhibiting the attribute; a medium storing known locations of the MTZs; and computer software containing instructions, which when executed, compare the known locations of the MTZs to the locations of the suspicious biological objects in order to determine a number of matches.
- 2. The kit of claim 1, wherein the at least one slide comprises a plurality of slides.
- 3. The kit of claim 1, wherein the MTZs comprise cells exhibiting an abnormal attribute.
- 4. The kit of claim 3, wherein the abnormal cells are selected from a group consisting of Low Grade Squamous Intraepithelial Lesions (LGSIL), High Grade Squamous Intraepithelial Lesions (HGSIL), Squamous Cell Carcinoma, Adenocarcinoma, and Adenocarcinoma in situ.
- 5. The kit of claim 1, wherein the medium is a computer medium.
- 6. The kit of claim 1, wherein the medium further stores statistical information relating to the MTZs.
- 7. The kit of claim 6, wherein the statistical information comprises a number of match counts between the known locations of the MTZs and the locations of suspected biological objects obtained from at least one other automated biological screening system.
- 8. The kit of claim 7, wherein the statistical information comprises a mean.
- 9. The kit of claim 7, wherein the statistical information comprises a tolerance interval.
- 10. The kit of claim 9, wherein the tolerance interval is defined such that a predefined percentage of the population is contained within the tolerance interval at at least a predefined confidence level.
- 11. The kit of claim 1, wherein the instructions, when executed, indicate that the automated biological screening system is qualified based on the number of matches.
- 12. The kit of claim 6, wherein the instructions, when executed, indicate that the automated biological screening system is qualified based on the number of matches and the statistical information.
- 13. A method of qualifying an automated biological screening system, comprising:
providing at least one biological specimen having a plurality of marked target zones (MTZs) exhibiting an attribute; processing the at least one biological specimen through the automated biological screening system to determine locations of biological objects suspected of exhibiting the attribute; and comparing the locations of the MTZs to the locations of the suspicious biological objects in order to determine a number of matches.
- 14. The method of claim 13, wherein the at least one biological specimen is carried by a slide.
- 15. The method of claim 13, wherein the at least one biological specimen comprises a plurality of biological specimens.
- 16. The method of claim 13, wherein the MTZs comprise cells exhibiting an abnormal attribute.
- 17. The method of claim 16, wherein the abnormal cells are selected from a group consisting of Low Grade Squamous Intraepithelial Lesions (LGSIL), High Grade Squamous Intraepithelial Lesions (HGSIL), Squamous Cell Carcinoma, Adenocarcinoma, and Adenocarcinoma in situ.
- 18. The method of claim 13, further comprising qualifying the automated biological screening system based on the number of matches.
- 19. The method of claim 13, further comprising qualifying the automated biological screening system based on the number of matches and statistical information relating to the MTZs.
- 20. The method of claim 19, wherein the statistical information comprises a number of match counts between the locations of the MTZs and the locations of suspected biological objects obtained from at least one other automated biological screening system.
- 21. The method of claim 20, wherein the statistical information comprises a mean, and the automated biological screening system is qualified based on the number of matches relative to the mean.
- 22. The method of claim 20, wherein the statistical information comprises a tolerance interval, and the automated biological screening system is qualified based on the number of matches that fall within the tolerance interval.
- 23. The method of claim 22, wherein the tolerance interval is defined such that a predefined percentage of the population is contained within the tolerance interval at at least a predefined confidence level.
- 24. A method of generating statistical information for a biological specimen, comprising:
providing at least one biological specimen having a plurality of marked target zones (MTZs) exhibiting an attribute; processing the at least one biological specimen through at least one automated biological screening system over a number of runs, wherein locations of biological objects suspected of exhibiting the attribute are determined for each processing run; comparing the locations of the MTZs to the locations of the suspicious biological objects in order to determine a number of matches for each run; and generating statistical information based on the number of matches for each run.
- 25. The method of claim 24, wherein the at least one biological specimen is carried by a slide.
- 26. The method of claim 24, wherein the at least one biological specimen comprises a plurality of biological specimens.
- 27. The method of claim 24, wherein the at least one automated biological screening system comprises a plurality of automated biological screening systems.
- 28. The method of claim 24, wherein the MTZs comprise cells exhibiting an abnormality.
- 29. The method of claim 28, wherein the abnormal cells are selected from a group consisting of Low Grade Squamous Intraepithelial Lesions (LGSIL), High Grade Squamous Intraepithelial Lesions (HGSIL), Squamous Cell Carcinoma, Adenocarcinoma, and Adenocarcinoma in situ.
- 30. The method of claim 19, wherein the statistical information comprises a number of match counts between the locations of the MTZs and the locations of suspected biological objects obtained from at least one other automated biological screening system.
- 31. The method of claim 30, wherein the statistical information comprises a mean of the number of matches determining over the runs.
- 32. The method of claim 30, wherein the statistical information comprises a tolerance interval for the number of matches.
- 33. The method of claim 32, wherein the tolerance interval is defined such that a predefined percentage of the population is contained within the tolerance interval at at least a predefined confidence level.
RELATED APPLICATIONS
[0001] This application claims priority from provisional U.S. Patent Application Ser. No. 60/478,208, filed Jun. 12, 2003.
Provisional Applications (1)
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Number |
Date |
Country |
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60478208 |
Jun 2003 |
US |