Claims
- 1. A method for suppressing immune reaction, comprising:
- administering to a subject in need thereof an effective amount of a compound of formula (I): ##STR10## wherein R.sup.1 is hydroxy or pharmaceutically acceptable protected hydroxy selected from the group consisting of 1-(lower alkylthio)(lower)alkyloxy, tri(lower)alkylsilyloxy, lower alkyldiphenyl-silyloxy, pharmaceutically acceptable organic carboxylic acyloxy, pharmaceutically acceptable organic sulfonic acyloxy, and pharmaceutically acceptable organic carbamic acyloxy,
- R.sup.2 is hydrogen or the same meanings as R.sup.1,
- R.sup.3 is methyl, ethyl, propyl or allyl, n is an integer of 1 or 2, and
- the symbol of a line and dotted line is a single bond or a double bond, or pharmaceutically acceptable basic salt thereof.
- 2. The method according to claim 1, wherein said compound of formula (I) is:
- 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0.sup.4,9 ]octacos-18-ene-2,3,10,16-tetraone.
- 3. The method according to claim 1, wherein said compound of formula (I) is:
- 17-ethyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0.sup.4,9 ]octacos-18-ene-2,3,10,16-tetraone.
Priority Claims (3)
Number |
Date |
Country |
Kind |
8430455 |
Mar 1984 |
GBX |
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8508420 |
Jan 1985 |
GBX |
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8502869 |
May 1985 |
GBX |
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Parent Case Info
This application is a Continuation of application Ser. No. 08/753,950, filed on Dec. 3, 1996, now U.S. Pat. No. 5,830,717, which is a Continuation of Ser. No. 08/450,412, filed May 25, 1995, now U.S. Pat. No. 5,624,842, which is a Divisional of Ser. No. 07/824,384, filed Jan. 23, 1992, abandoned, which is a Divisional of Ser. No. 07/491,205, filed Mar. 9, 1990, now U.S. Pat. No. 5,110,811, which is a Continuation of Ser. No. 06/868,749, filed May 30, 1986, now U.S. Pat. No. 4,929,611, which is a Continuation in Part of Ser. No. 06/799,855, filed Nov. 20, 1985, now U.S. Pat. No. 4,894,366.
US Referenced Citations (8)
Divisions (2)
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824384 |
Jan 1992 |
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Parent |
491205 |
Mar 1990 |
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Continuations (3)
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753950 |
Dec 1996 |
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Parent |
450412 |
May 1995 |
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Parent |
868749 |
May 1986 |
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Continuation in Parts (1)
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799855 |
Nov 1985 |
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