Claims
- 1. A method of increasing the biological activity of a bioactive agent comprising the steps of complexing the bioactive agent to a complexing agent, wherein the biological activity of a bioactive agent/complexing agent complex is higher than the activity of an uncomplexed bioactive agent.
- 2. The method of claim 1, wherein the bioactive agent is an antibiotic.
- 3. The methods of claim 2, wherein the antibiotic is a hydrophobic antibiotic.
- 4. The method of claim 2, wherein the antibiotic is selected from the group consisting of tetracycline, tobramycin, and gentamicin.
- 5. The methods of claim 2, wherein the antibiotic is chlorhexidine.
- 6. The methods of claim 2, wherein the antibiotic is chlorhexidine digluconate.
- 7. The method of claim 1, wherein the complexing agent is cyclodextrin.
- 8. The method of claim 7, wherein the cyclodextrin is a naturally occurring cyclodextrin.
- 9. The method of claim 7, wherein the cyclodextrin is a chemically modified cyclodextrin.
- 10. A method of increasing the biological activity of an antibiotic against a microbial agent comprising complexing the antibiotic to a cyclodextrin, wherein the biological activity of a cyclodextrin/antibiotic complex is higher than the activity of an uncomplexed antibiotic.
- 11. The method of claim 10 wherein the antibiotic is hydrophobic.
- 12. The method of claim 10, wherein the antibiotic is selected from the group consisting of tetracycline, tobramycin, and gentamicin.
- 13. The method of claim 10, wherein the antibiotic is chlorhexidine.
- 14. The method of claim 10, wherein the antibiotic is chlorhexidine digluconate.
- 15. The method of claim 10, wherein the cyclodextrin is a naturally occurring cyclodextrin.
- 16. The method of claim 10, wherein the cyclodextrin is a chemically modified cyclodextrin.
- 17. A method of treating a microbial infection in an animal comprising administering to the animal an effective amount of an antibiotic that is complexed to a cyclodextrin.
- 18. The method of claim 17, wherein the antibiotic is hydrophobic.
- 19. The method of claim 17, wherein the antibiotic is selected from the group consisting of tetracycline, tobramycin, and gentamicin.
- 20. The method of claim 17, wherein the antibiotic is chlorhexidine.
- 21. The method of claim 17, wherein the antibiotic is chlorhexidine digluconate.
- 22. The method of claim 17, wherein the cyclodextrin is a naturally occurring cyclodextrin.
- 23. The method of claim 17, wherein the cyclodextrin is a chemically modified cyclodextrin.
PRIORITY INFORMATION
[0001] This Application is related to the subject matter in U.S. pending application Ser. No. 09/543,964 filed Apr. 7, 2000 and claims benefit of U.S. Provisional Application No. 60/241,054, filed Oct. 17, 2000. The contents of these applications are incorporated herein by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60241054 |
Oct 2000 |
US |