Claims
- 1. A method of inhibiting aromatase, comprising administering to a mammal in need thereof a pharmaceutical composition comprising an effective aromatase inhibiting amount of a compound of the formula (I): ##STR10## wherein X.sub.1 is a chlorine or fluorine atom, or a hydroxy group, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
- 2. A method according to claim 1, wherein a racemic mixture of compounds of the formulas [I(t-(+))] and [I(t-(-))] are administered: ##STR11## wherein X.sub.1 is a chlorine or fluorine atom, or a hydroxy group, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
- 3. A method according to claim 1, wherein a compound of the formula [I(t-(+))] is administered: ##STR12## wherein X.sub.1 is a chlorine or fluorine atom, or a hydroxy group, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
- 4. A method according to claim 1, wherein a compound of the formula [I(t-(-))] is administered: ##STR13## wherein X.sub.1 is a chlorine or fluorine atom, or a hydroxy group, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
- 5. A method according to claim 1, wherein a racemic mixture of compounds of the formulas [I(c-(+))] and [I(c-(-))] are administered: ##STR14## wherein X.sub.1 is a chlorine or fluorine atom, or a hydroxy group, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
- 6. A method according to claim 1, wherein a compound of the formula [I(c-(+))] is administered: ##STR15## wherein X.sub.1 is a chlorine or fluorine atom, or a hydroxy group, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
- 7. A method according to claim 1, wherein a compound of the formula [I(c-(-))] is administered: ##STR16## wherein X.sub.1 is a chlorine or fluorine atom, or a hydroxy group, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
- 8. A method according to claim 1, wherein a tumor in the mammal is treated.
- 9. A method according to claim 2, wherein a tumor in the mammal is treated.
- 10. A method according to claim 3, wherein a tumor in the mammal is treated.
- 11. A method according to claim 4, wherein a tumor in the mammal is treated.
- 12. A method according to claim 5, wherein a tumor in the mammal is treated.
- 13. A method according to claim 6, wherein a tumor in the mammal is treated.
- 14. A method according to claim 7, wherein a tumor in the mammal is treated.
Priority Claims (2)
Number |
Date |
Country |
Kind |
4-61441 |
Feb 1992 |
JPX |
|
PCT/JP93/00181 |
Feb 1993 |
WOX |
|
CROSS REFERENCE TO RELATED APPLICATION
This is a continuation-in-part application of patent application Ser. No. 08/137,045 filed on Oct. 4, 1993, now U.S. Pat. No. 5,489,597, which was derived from International Patent Application No. PCT/JP93/00181 filed on Feb. 12, 1993.
Foreign Referenced Citations (3)
Number |
Date |
Country |
0324646 |
Jul 1989 |
EPX |
0413448 |
Feb 1991 |
EPX |
3197464 |
Aug 1991 |
JPX |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
137045 |
Oct 1993 |
|