Claims
- 1. A method of inhibiting gastric acid secretion in mammals comprising administering to a mammal in need of gastric acid secretion inhibition a pharmaceutically effective dose of a direct acting 5-HT1A agonist which is a trans-2-phenylcyclopropylamine or a pharmaceutically acceptable salt thereof.
- 2. The method according to claim 1 wherein said mammals are humans.
- 3. The method according to claim 2 wherein said 2-phenylcyclopropylamine has the Formula: ##STR38## where R.sup.13 is C.sub.1 -C.sub.3 alkyl;
- X.sup.3 is hydrogen, OH or OCH.sub.3,
- Y is hydrogen, OH or OCH.sub.3, provided that one of X.sup.3 and Y must be hydrogen; or a pharmaceutically acceptable salt thereof.
- 4. The method according to claim 3 wherein R.sup.13 is n-propyl.
- 5. The method according to claim 4 wherein X.sup.3 is H and Y is OH.
- 6. The method according to claim 4 wherein X.sup.3 is OH and Y is H.
Parent Case Info
This application is a division of application Ser. No. 07/898,991, filed Jun. 15, 1992, now U.S. Pat. No. 5,232,946 which is a division of application Ser. No. 07/707,357, filed on May 29, 1991, now U.S. Pat. No. 5,158,956 which is a continuation-in-part of application Ser. No. 07/519,388, filed on May, 4, 1990, now U.S. Pat. No. 5,096,908.
US Referenced Citations (3)
Non-Patent Literature Citations (1)
Entry |
Arvidsson, L. E., et al., J. Med. Chem., 31, 92-99 (1988). |
Divisions (2)
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Number |
Date |
Country |
Parent |
898991 |
Jun 1992 |
|
Parent |
707357 |
May 1991 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
519388 |
May 1990 |
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