Claims
- 1. A method of inhibiting gastric acid secretion in mammals in need of gastric acid secretion inhibition comprising administering to said mammal a pharmaceutically effective dose of a direct acting 5-HT.sub.1A agonist which is a 4-amino-1,3,4,5-tetrahydrobenz[c,d]indole or a pharmaceutically acceptable salt thereof.
- 2. The method according to claim 1 wherein said mammals are humans.
- 3. The method according to claim 2 wherein said 4-amino-1,3,4,5-tetrahydrobenz[c,d]indole has the Formula: ##STR40## where R.sup.4 and R.sup.5 are individually selected from hydrogen, methyl, ethyl, n-propyl and allyl;
- X.sup.1 is OH, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkylthio, O-acyl, halogen, CN, CONH.sub.2, NH.sub.2, NO.sub.2, COO(C.sub.1 -C.sub.3 alkyl), CHO, or C(O)S (C.sub.1 -C.sub.3) alkyl; or a pharmaceutically acceptable acid addition salt thereof.
- 4. The method according to claim 3 wherein X.sup.1 is OH, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkylthio, CONH.sub.2 or COO(C.sub.1 -C.sub.3)alkyl.
- 5. The method according to claim 4 wherein R.sup.4 and R.sup.5 are both n-propyl.
- 6. The method according to claim 5 where X.sup.1 is OH, OCH.sub.3, SCH.sub.3, CONH.sub.2, or COOCH.sub.3.
- 7. The method according to claim 6 wherein X.sup.1 is OCH.sub.3.
- 8. The method according to claim 6 wherein X.sup.1 is SCH.sub.3.
- 9. The method according to claim 6 wherein X.sup.1 is CONH.sub.2.
Parent Case Info
This application is a division of application Ser. No. 08/068,723, filed May 26, 1993, now U.S. Pat. No. 5,340,838 which is a division of application Ser. No. 07/898,991, filed Jun. 15, 1992, now U.S. Pat. No. 5,258,379, which is a division of application Ser. No. 07/707,357, filed on May 29, 1991, now U.S. Pat. No. 5,158,956 which is a continuation-in-part of application Ser. No. 07/519,388, filed on May 4, 1990, now U.S. Pat. No. 5,096,908.
US Referenced Citations (4)
Foreign Referenced Citations (2)
Number |
Date |
Country |
148440 |
Jul 1985 |
EPX |
153083 |
Aug 1985 |
EPX |
Non-Patent Literature Citations (1)
Entry |
Handbook of Experimental Pharmacology, vol. XIX "5-Hydroxytrofptanine and Related Indolealkylanines", Erspaner, v. sub-ed, Springer-Verlog, New York, 1966, pp. 329-335. |
Divisions (3)
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Number |
Date |
Country |
Parent |
68723 |
May 1993 |
|
Parent |
898991 |
Jun 1992 |
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Parent |
707357 |
May 1991 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
519388 |
May 1990 |
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