Claims
- 1. A method of inhibiting gastric acid secretion in mammals in need of gastric acid secretion inhibition comprising administering to said mammal a pharmaceutically effective dose of a direct acting 5-HT.sub.1A agonist which is a 5-substituted-3-aminochromane or a pharmaceutically acceptable acid addition salt thereof.
- 2. The method according to claim 1 wherein said mammals are humans.
- 3. The method according to claim 2 wherein said 5-substituted-3-aminochromane has the formula ##STR39## where R is C.sub.1 -C.sub.4 alkyl, allyl, or cyclopropylmethyl; R.sup.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, allyl, or cyclopropylmethyl, or aryl(C.sub.1 -C.sub.4 -alkyl);
- R.sup.2 is hydrogen or methyl;
- X is --O--;
- R.sup.3 is C.sub.1 -C.sub.8 alkyl, aryl, substituted aryl, aryl(C.sub.1 -C.sub.4 -alkyl), substituted aryl(C.sub.1 -C.sub.4 alkyl), or C.sub.5 -C.sub.7 cycloalkyl;
- n is 0, 1, or 2;
- and pharmaceutically acceptable acid addition salts thereof.
- 4. The method according to claim 3 wherein said 5-substituted-3-aminochromane is 3-(di- n-propylamino)-5-methylthiochromane or a pharmaceutically acceptable acid addition salt thereof.
Parent Case Info
This application is a division of prior application Ser. No. 08/387,492, filed Feb. 13, 1995, which is a division of prior application Ser. No. 08/219,157, filed Mar. 29, 1994, now U.S. Pat. No. 5,457,120, which is a division of prior application Ser. No. 08/068,723, filed May 26, 1993, now U.S. Pat. No. 5,340,838, which is a division of prior application Ser. No. 07/898,991, filed Jun. 15, 1992, now U.S. Pat. No. 5,258,379, which is a division of prior application Ser. No. 07/707,357, filed May 29, 1991, now U.S. Pat. No. 5,158,956, which is a continuation-in-part of application Ser. No. 07/519,388, filed May 4, 1990, now U.S. Pat. No. 5,096,908.
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Divisions (5)
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Number |
Date |
Country |
Parent |
387492 |
Feb 1995 |
|
Parent |
219157 |
Mar 1994 |
|
Parent |
68723 |
May 1993 |
|
Parent |
898991 |
Jun 1992 |
|
Parent |
707357 |
May 1991 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
519388 |
May 1990 |
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