Claims
- 1. A method of inhibiting gastric acid secretion in mammals in need of gastric acid secretion inhibition comprising administering to said mammal a pharmaceutically effective dose of a direct acting 5-HT.sub.1A agonist which is an 8-substituted-2-amino-1,2,3,4-tetrahydronaphthalene or a pharmaceutically acceptable acid addition salt thereof.
- 2. The method according to claim 1 wherein said mammals are humans.
- 3. The method according to claim 2 wherein said 8-substituted -2-amino-1,2,3,4-tetrahydronaphthalene has the formula: ##STR40## where R is C.sub.1 -C.sub.4 alkyl, allyl, or (C.sub.3 -C.sub.5 cycloalkyl)methyl;
- R.sup.1 is hydrogen, C.sub.1 -C.sub.4 alkyl; allyl; (C.sub.3 -C.sub.5 cycloalkyl)-methyl, or aryl(C.sub.1 -C.sub.4 alkyl);
- R.sup.2 is hydrogen or methyl;
- X.sup.4 is OH, C.sub.1 -C.sub.3 alkoxy, halo, COOR.sup.3 or S(O).sub.n R.sup.3 ;
- R.sup.3 is C.sub.1 -C.sub.8 alkyl, aryl, substituted aryl, aryl(C.sub.1 -C.sub.4 -alkyl), substituted aryl(C.sub.1 -C.sub.4 alkyl); or C.sub.5 -C.sub.7 cycloalkyl; or R and R.sup.1 are taken together with the nitrogen atom to form a group; ##STR41## where A is 3-trifluoromethylphenyl, 3-halophenyl, 2-pyrimidinyl, halopyrimidin-2-yl, 2-pyrazinyl or halo-2-pyrazinyl;
- n is 0, 1, or 2; or a pharmaceutically acceptable acid addition salt thereof.
- 4. The method according to claim 3 wherein R.sup.2 is H.
- 5. The method according to claim 4 wherein X.sup.4 is OH, C.sub.1 -C.sub.3 alkoxy or S(O).sub.n R.sup.3 and n is 0.
- 6. The method according to claims 5 wherein X.sup.4 is OH, OCH.sub.3 or SCH.sub.3.
- 7. The method according to claims 6 wherein R and R.sup.1 are both C.sub.1 -C.sub.4 alkyl or cyclopropylmethyl.
- 8. The method according to claim 7 wherein R and R.sup.1 are both n-propyl.
- 9. The method according to claim 7 wherein R and R.sup.1 are both cyclopropylmethyl.
Parent Case Info
This application is a division of prior application Ser. No. 08/387,492, filed Feb. 13, 1995, which is a division of prior application is a division of prior application Ser. No. 08/219,157, filed Mar. 29, 1994 now U.S. Pat. No. 5,457,120, which is a division of prior application Ser. No. 08/068,723, filed May 26, 1993, now U.S. Pat. No. 5,340,838, which is a division of prior application Ser. No. 07/898,991, filed Jun. 15, 1992, now U.S. Pat. No. 5,258,379, which is a division of prior application Ser. No. 07/707,357, filed May 29, 1991, now U.S. Pat. No. 5,158,956, which is a continuation-in-part of application Ser. No. 07/519,388, filed May 4, 1990, now U.S. Pat. No. 5,096,908.
US Referenced Citations (5)
Non-Patent Literature Citations (1)
Entry |
Chemical Abstracts 94: 58494 (J.P. 55069511) abstract copy. |
Divisions (5)
|
Number |
Date |
Country |
Parent |
387492 |
Feb 1995 |
|
Parent |
219157 |
Mar 1994 |
|
Parent |
68723 |
May 1993 |
|
Parent |
898991 |
Jun 1992 |
|
Parent |
707357 |
May 1991 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
519388 |
May 1990 |
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