Claims
- 1. A method of inhibiting gastric acid secretion in mammals comprising administering to a mammal in need of gastric acid secretion inhibitions a pharmaceutically effective dose of a direct acting 5-HT1a agonist or a pharmaceutically acceptable salt thereof.
- 2. The method according to claim 1 wherein said mammals are humans.
- 3. The method according to claim 2 wherein said 5-HT1A agonist is a benzodioxane or a pharmaceutically acceptable acid addition salt thereof.
- 4. The method according to claim 3 wherein said benzodioxane has the Formula: ##STR40## where X.sup.6 is hydrogen, hydroxy, or --O(C.sub.1 -C.sub.3)alkyl;
- R.sup.15 is hydrogen; and
- R.sup.16 is --(CH.sub.2).sub.d --Y.sup.2 --Z.sup.1 where d is 2-4;
- Y.sup.2 is a bond, --O-- or --S--; and Z.sup.1 is unsubstituted, mono- or disubstituted phenyl where the substituents are selected from halo, trifluoromethyl, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, or C.sub.1 -C.sub.3 alkylthio; or a C.sub.3 --C.sub.6 cycloalkyl group or a 8-azaspiro4,5]decan-7,9-dione group; or NR.sup.15 R.sup.16 comprises a 8-(1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one) group; or a pharmaceutically acceptable salt thereof.
- 5. The method according to claim 4 wherein --NR.sup.15 R.sup.16 are taken together to comprise an 8-(1-phenyl-1,3,8-triazaspiro4,5]decan-4-one)group.
- 6. The method according to claim 4 wherein Y.sup.2 is a bond.
- 7. The method according to claim 6 wherein X.sup.6 is OH.
- 8. The method according to claim 7 wherein Z.sup.1 is a cyclohexyl group.
- 9. The method according to claim 4 wherein X.sup.6 is hydrogen, R.sup.15 is hydrogen, Y.sup.2 is a bond and Z.sup.1 is an 8-azaspiro[4,5]decan-7,9-dione group.
Parent Case Info
This application is a continuation-in-part of application Ser. No. 07/519,388, filed on May 4, 1990, U.S. Pat. No. 5,096,908.
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Date |
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2906757 |
Mills et al. |
Sep 1959 |
|
2922744 |
Mills et al. |
Jan 1960 |
|
4794118 |
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|
Foreign Referenced Citations (1)
Number |
Date |
Country |
170213 |
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EPX |
Non-Patent Literature Citations (1)
Entry |
Nelson, W. L. et al., J. Med. Chem., 20, 880-885 (1977). |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
519388 |
May 1990 |
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