Patent Grant
10301400
To produce stereoregular polymers, catalytic insertion polymerization is the method of choice. Resulting stereoregular poly(1-olefins) and poly(dienes) are of enormous practical importance. An introduction of polar groups in such stereoregular polymerizations is challenging, however, due to the sensitivity of most catalysts towards heteroatom-containing substrates. An introduction of polar and reactive groups in the polymer backbone and into the end-groups in particular is desirable to enhance the compatibility with polar surface, like e.g. metals or fillers and for cross-linking. Concerning an incorporation into the polymer chain, recent work has resulted in an advance towards stereoregular polar functionalized poly(propylene) (Nozaki et al., Angew. Chem., Int. Ed. 2016, 55, (26), 7505-7509.) For poly(dienes), insertion polymerization of functionalized dienes and other pathways to stereoregular poly(dienes) have been reported (Leicht et al., S. ACS Macro Lett. 2016, 5, (6), 777-780; Leicht et al., Polym. Chem. 2016; Cui et al., Polym. Chem. 2016, 7, (6), 1264-1270.) Examples for syntheses of chain-end functionalized poly(dienes) are so far based on methods like anionic polymerization (Quirk et al., Polymer 2004, 45, (3), 873-880; Stewart et al., British Polymer Journal 1990, 22, (4), 319-325.) or ring opening metathesis polymerization (Hillmyer et al., Macromolecules 1997, 30, (4), 718-721; Ji et al., Macromolecules 2004, 37, (15), 5485-5489; Chung et al., Macromolecules 1992, 25, (20), 5137-5144) that do not provide access to stereoregular polymers. There remains a need for a method to produce stereoregular polymers functionalized with polar groups.
Most lanthanide-based catalyst precursors for stereoselective diene polymerization require activation by a second reagent, often organo-metal compounds. The present invention includes the usage of polar functionalized organo-metal activators for the synthesis of chain-end functionalized stereoregular dienes. Further, the combination of this method with the generation of functionalized chain-ends by quenching at the end of the polymerization and direct copolymerization with functionalized dienes gives access to stereoregular, trifunctional, hetero-telechelic poly(dienes).
The preparation of stereoregular poly(dienes) with functional groups in the main chain as well as in both end-groups, the later in a hetero-telechelic fashion is disclosed. A key element is the finding that Nd-based trans-selective systems for diene polymerization are tolerant towards different functional groups based on nitrogen or sulfur. Further, activation of Nd(BH4)3.(THF)3 proceeds with functionalized magnesium alkyls to introduce functional groups at the initiating chain-ends. At the terminating chain-end, an end-group could be generated by conversion of reactive metal-carbon bonds present in the catalyst system with suitable quenching reagents. Notably, all three elements are compatible with one another and can be carried out together, i.e. stereoregularity or the nature of the reactive metal-polymeryl bonds are not compromised by the presence of functional activators or monomers.
Stereoregular poly(dienes) with three different functional groups were synthesized by insertion polymerization. The functional groups are located simultaneously in the polymer backbone and at both chain ends, yielding hetero-telechelic and in-chain functionalized polymers. A combination of three compatible functionalization methods allows for the syntheses of these particular polymers. Nd(BH4)3.(THF)3 catalyzes, after activation with MgR2, the direct copolymerization of 1,3-butadiene or isoprene with polar functionalized dienes, thus enabling the functionalization of the polymer's backbone. The use of functionalized organo-Mg compounds, like (PhS—C5H10)2Mg, for the activation of Nd(BH4)3.(THF)3 enables the functionalization of one chain-end and quenching of the polymerization with suitable reagents like Si(OEt)4 allows for the functionalization of the other chain-end. While activation of Nd(BH4)3.(THF)3 with MgR2 initiates usually a 1,4-trans selective diene polymerization, the use of polar organo-Mg compounds as activation reagents has also been shown to be a viable method for chain-end functionalization in cis-selective diene polymerizations.
The present invention therefore involves the use of functional magnesium-based chain transfer reagants that impart functionality on the end of every polymer chain. By combining this technique with known functionalization techniques such as termination with functional terminators or copolymerization with functional monomers, the invention describes a method to make stereoregular polymers that contain functionality on both ends, as well as in-chain. Either high-cis or high-trans polymers can be made through changes to the catalyst system, without affecting the functionalization reactions.
The present invention is directed to a method of making a functionalized elastomer, comprising the step of polymerizing a conjugated diene monomer in the presence of a lathanide-based coordination polymerization catalyst activated with a magnesium compound of formula 1
where R1 is phenylene, or a linear or branched alkane diyl group containing 2 to 10 carbon atoms, or a combination of one or more phenylene groups and one or more linear or branched alkane diyl groups containing 1 to 10 carbon atoms; Q is of formula 2 or 3
where R2 is phenyl, or a linear or branched alkyl group containing 2 to 10 carbon atoms;
where R3 and R4 are independently phenyl or a linear or branched alkyl group containing 1 to 10 carbon atoms, or R2 and R3 taken together with the nitrogen atom represent a nitrogen containing heterocyclic group containing from 4 to 12 carbon atoms.
There is further disclosed a rubber composition comprising the functionalized elastomer produced by this method, and a tire comprising the rubber composition.
There is disclosed a method of making a functionalized elastomer, comprising the step of polymerizing a conjugated diene monomer in the presence of a lathanide-based coordination polymerization catalyst activated with a magnesium compound of formula 1
where R1 is phenylene, or a linear or branched alkane diyl group containing 2 to 10 carbon atoms, or a combination of one or more phenylene groups and one or more linear or branched alkane diyl groups containing 1 to 10 carbon atoms;
Q is of formula 2 or 3
where R2 is phenyl, or a linear or branched alkyl group containing 2 to 10 carbon atoms;
where R3 and R4 are independently phenyl or a linear or branched alkyl group containing 1 to 10 carbon atoms, or R2 and R3 taken together with the nitrogen atom represent a nitrogen containing heterocyclic group containing from 4 to 12 carbon atoms.
Polymerizations according to the method utilitize a lanthanide based catalyst system. Suitable catalysts include neodymium based catalysts, including neodymium borohydride complexes activated with dialkylmagnesium compounds, and neodymium carboxylates activated with dialkylmagnesium compounds and alkyl aluminum chlorides.
Such polymerizations are typically conducted in a hydrocarbon solvent that can be one or more aromatic, paraffinic, or cycloparaffinic compounds. These solvents will normally contain from 4 to 10 carbon atoms per molecule and will be liquids under the conditions of the polymerization. Some representative examples of suitable organic solvents include pentane, isooctane, cyclohexane, normal hexane, benzene, toluene, xylene, ethylbenzene, and the like, alone or in admixture.
In one embodiment, the neodymium catalyst system is a neodymium borohydride activated with a functional dialkyl magnesium compound. In one embodiment, the neodymium borohydride is Nd(BH4)3.(THF)3 where THF is tetrahydrofuran. Suitable functional dialkyl magnesium compounds included compound of formula 1
where R1 is phenylene, or a linear or branched alkane diyl group containing 2 to 10 carbon atoms, or a combination of one or more phenylene groups and one or more linear or branched alkane diyl groups containing 1 to 10 carbon atoms;
Q is of formula 2 or I3
where R2 is phenyl, or a linear or branched alkyl group containing 2 to 10 carbon atoms;
where R3 and R4 are independently phenyl or a linear or branched alkyl group containing 1 to 10 carbon atoms, or R2 and R3 taken together with the nitrogen atom represent a nitrogen containing heterocyclic group containing from 4 to 12 carbon atoms.
In one embodiment, the neodymium catalyst system used in the process of this invention is made by preforming three catalyst components. These components are (1) the functional dialkyl magnesium compound of formula I, (2) a neodymium carboxylate, and (3) an alkyl aluminum chloride. In making the neodymium catalyst system the neodymium carboxylate and the alkyl aluminum chloride compound are first reacted together for 10 seconds to 30 minutes in the presence of isoprene or butadiene to produce a neodymium-aluminum catalyst component. The neodymium carboxylate and the organoaluminum compound are preferable reacted for 2 minutes to 30 minutes and are more preferable reacted for 3 to 25 minutes in producing the neodymium-aluminum catalyst component.
The neodymium-aluminum catalyst component is then reacted with the functional dialkyl magnesium compound to yield the active catalyst system.
The neodymium catalyst system will typically be pre-formed at a temperature that is within the range of about 0° C. to about 100° C. The neodymium catalyst system will more typically be prepared at a temperature that is within the range of about 10° C. to about 60° C.
The neodymium carboxylate utilizes an organic monocarboxylic acid ligand that contains from 1 to 20 carbon atoms, such as acetic acid, propionic acid, valeric acid, hexanoic acid, 2-ethylhexanoic acid, neodecanoic acid, lauric acid, stearic acid and the like neodymium naphthenate, neodymium neodecanoate, neodymium octanoate, and other neodymium metal complexes with carboxylic acid containing ligands containing from 1 to 20 carbon atoms.
The concentration of the total catalyst system employed of course, depends upon factors such as purity of the system, polymerization rate desired, temperature and other factors. Therefore, specific concentrations cannot be set forth except to say that catalytic amounts are used.
Temperatures at which the polymerization reaction is carried out can be varied over a wide range. Usually the temperature can be varied from extremely low temperatures such as −60° C. up to high temperatures, such as 150° C. or higher. Thus, the temperature is not a critical factor of the invention. It is generally preferred, however, to conduct the reaction at a temperature in the range of from about 10° C. to about 90° C. The pressure at which the polymerization is carried out can also be varied over a wide range. The reaction can be conducted at atmospheric pressure or, if desired, it can be carried out at sub-atmospheric or super-atmospheric pressure. Generally, a satisfactory polymerization is obtained when the reaction is carried out at about autogenous pressure, developed by the reactants under the operating conditions used.
Examples of useful functional dialkyl magnesium compounds of formula 1 include but are not limited to compounds such as the following
The polymerization can be quenched or terminated by the addition of a functional terminator, an alcohol or another protic source, such as water.
In one embodiment, the polymerization is terminated using a functional terminator. By functional terminator, it is meant an organic compound capable of terminating the polymerization reaction, wherein the organic compound is substituted with a functional group comprising at least one heteroatom selected from phosphorus, boron, oxygen, halogens and silicon.
In one embodiment, the functional terminator comprises at least one functional group selected from the group consisting of phosphane, phosphonic acid, phosphate, phosphodiester, phosphotriester, silyl, alklysilyl, alkoxysilyl, and siloxy.
Useful functional terminators include but are not limited to tetraethoxysilane, n-octyltriethoxysilane, 3-chloropropyltriethoxysilane, and chlorodiphenylphosphine.
Suitable monomers for use in the polymerization are conjugated diene monomers and functionalized versions thereof. Suitable conjugated diene monomers include 1,3-butadiene and isoprene. Other suitable conjugated diene monomers include 2,3-dimethyl-1,3-butadiene, piperylene, 3-butyl-1,3-octadiene, 2-phenyl-1,3-butadiene, and the like, and combinations thereof.
In one embodiment, the monomer includes a functionalized monomer of formula 4
wherein R6 is a covalent bond, phenylene, a linear or branched alkane diyl group containing 1 to 10 carbon atoms, or a combination of one or more phenylene groups and one or more linear or branched alkane diyl groups containing 1 to 10 carbon atoms; R7 is hydrogen or a linear or branched alkyl group containing 1 to 10 carbon atoms; X1 is selected from formulas 5 and 6
wherein R8 and R9 are independently trialkylsilyl, phenyl or a linear or branched alkyl group containing 1 to 10 carbon atoms, or one of R8 and R9 is hydrogen and the other is phenyl or a linear or branched alkyl group containing 1 to 10 carbon atoms, or R8 and R9 taken together with the nitrogen atom represent a nitrogen containing heterocyclic group containing from 4 to 12 carbon atoms; and X2 is a sulfur atom or a structure of formula 7 or 8
wherein when X2 is of formula 8, the S atom of formula 8 is adjacent to the phenyl ring of formula 6 and the N atom of formula 8 is adjacent to R6.
In one embodiment, the nitrogen containing heterocyclic group is selected from the group consisting of the structures
wherein R5 groups can be the same or different and represent a member selected from the group consisting of linear or branched alkyl groups containing from 1 to about 10 carbon atoms, aryl groups, allyl groups, and alkoxy groups, and wherein Y represents oxygen, sulfur, or a methylene group, and n is an integer from 4 to 12.
In one embodiment, suitable functionalized monomers are selected from the following monomer structures
where in monomer 3, TMS refers to a trimethylsilyl group.
The use of functional magnesium-based chain transfer reagents of formula 1 imparts functionality on the end of every polymer chain end. By combining the technique with known functionalization techniques such as termination with functional terminators or copolymerization with functional monomers, the polymerization results in stereoregular polymers that contain functionality on both ends, as well as in-chain. Either high-cis or high-trans polymers can be made through changes to the catalyst system, without affecting the functionalization reactions. By stereoregular, it is meant that the polymer microstructure includes at least 80 percent by weight of monomer residues (i.e., polymer subunits derived from a given monomer) in the cis 1,4-configuration, or 90 percent by weight of monomer residues in the trans 1,4-configuration. In one embodiment, the polymer contains at least 85 percent by weight of monomer residues in cis 1,4-configuration. In one embodiment, the polymer contains at least 95 percent by weight of monomer residues in trans 1,4-configuration.
This invention is illustrated by the following examples that are merely for the purpose of illustration and are not to be regarded as limiting the scope of the invention or the manner in which it can be practiced. Unless specifically indicated otherwise, parts and percentages are given by weight.
Homopolymerizations of BD were performed to optimize polymerization conditions for high stereoselectivity and to assess the influence of the diene:Nd ratio on the molecular weights and molecular weight distributions of the obtained polymers. 5 μmol Nd(BH4)3.(THF)3 were activated with 1 equiv. of MgBu2 in the presence of different amounts of BD in toluene (Table 1, entries 1-3). Polymerization at 60° C. for 5 h yielded in all cases highly stereoregular 1,4-trans-PBD (≥95 mol % trans-units). The molecular weights of the obtained polymers are close to the theoretically calculated molecular weights (for a polymerization where only one polymer chain per Nd is formed) and increase linearly with increasing BD:Nd ratio. Although GPC analyses indicate a bimodal molecular weight distribution (cf. SI), all molecular weight distributions are narrow (Mw/Mn=1.3-1.6). Hence, a controlled character of the polymerization can be assumed. DSC analyses of the polymers gave the typically two distinct melting points for high 1,4-trans-PBD. Not only butadiene but also isoprene is stereoselectively polymerized. A polymerization of isoprene in an NMR tube gives poly(isoprene) with 95% 1,4-trans units (Table 1, entry 4). The narrow molecular weight distribution and a molecular weight close to the theoretical value also indicate a controlled polymerization of isoprene. Having established the general polymerization behavior under our conditions of the catalyst system based on Nd(BH4)3.(THF)3, three different approaches for the functionalization of the obtained stereoregular poly(diene) were explored: 1) The direct introduction of polar groups into the backbone of the polymer by insertion copolymerization of butadiene or isoprene with polar functionalized dienes. 2) The functionalization of one chain-end by reaction of the reactive metal-carbon bond with a suitable quenching reagent. 3) The functionalization of the other chain-end by using polar functionalized Mg-compounds.
Polymerization conditions: Nd(BH4)3.(THF)3:MgBu2=1:1, T=60° C. in toluene a) determined by 1H NMR b) determined by GPC in THF vs. PS standards. c) determined by DSC d) determined by 13C NMR e) incorporation not determined because comonomer incorporation signals are overlapped by the polymer backbone. f) quenched with 600 μmol Si(OEt)4. g) quenched with 600 μmol Ph2PCl.
Copolymerization with Polar Functionalized Dienes.
The functional group tolerance of Nd(BH4)3.(THF)3 activated with MgR2 in diene polymerizations was tested with comonomers 1-5 (Table 1-A, entries 7-12).
Chart 1: Polar functionalized dienes used in copolymerizations with butadiene and isoprene.
Polymerization conditions: Nd(BH4)3.(THF)3:MgBu2=1:1, T=60° C. in toluene a) determined by 1H NMR b) determined by GPC in THF vs. PS standards. c) determined by DSC d) determined by 13C NMR e) incorporation not determined because comonomer incorporation signals are overlapped by the polymer backbone. f) quenched with 600 μmol Si(OEt)4. g) quenched with 600 μmol Ph2PCl.
Comparison of the copolymerizations with a BD homopolymerization under otherwise identical conditions reveals no to little adverse impact of the comonomer present on yield, molecular weight and stereoselectivity (e.g. Table 1, 1-A, entry 1 vs. 7). Copolymerizations with 3 and 5 result in polymers with broader molecular weight distributions. Additionally, copolymers of 1 and 3 exhibit a lowered second melting point. Incorporation of 1 and 3 proceeds efficiently (73% and 99% comonomer conversion) and yields copolymers with incorporations of 3.9 mol % and 3.6 mol % respectively (
These polymerizations prove that Nd(BH4)3.(THF)3 activated with MgR2 is a viable catalyst system for the direct copolymerization of butadiene or isoprene with functionalized dienes to polar functionalized 1,4-trans-poly(dienes).
Chain-End Functionalization by Quenching.
The second part of the functionalization strategy aims at the reaction of reactive metal-carbon bonds present with a suitable quenching reagent (Scheme 1).
Scheme 1: Chain-end functionalization by reaction of metal-polymer carbon bonds with Si(OEt)4 as reactive quenching reagents.
We tested four different quenching reagents, Si(OEt)4, Ph2PCl, B(OEt)3, and P(O)(OEt)3 towards their reactivity with the aforementioned metal-carbon bonds. For this purpose, polymerizations run with an IP:Nd ratio of 100:1 were terminated by the addition of the quenching reagents (cf. Table 1, entries 5 and 6, for examples with Si(OEt)4 and Ph2PCl). The reaction mixture was stirred at the polymerization temperature until it became colorless. The polymers were isolated by precipitation in dry acetonitrile (polymers quenched with Si(OEt)4, B(OEt)3, or P(O)(OEt)3) or acidified MeOH (Ph2PCl-modified) followed by drying under reduced pressure. To verify the functionalization by quenching, the polymers were subjected to a thorough analysis by means of NMR spectroscopy. 1H and 13C NMR showed no indication for a successful functionalization for polymers quenched with B(OEt)3 or P(O)(OEt)3. In contrast, the polymer quenched with Si(OEt)4 exhibits characteristic shifts for an ethoxy-moiety in the 1H NMR spectrum at δ=3.89 ppm and δ=1.20 ppm (
A quantitative view on the end-group functionalization reveals that the reaction does not proceed quantitatively, with quenching efficiencies (i.e. portion of chains functionalized) between 40 and 50%.
A polymer quenched with Ph2PCl at the end of the polymerization reaction exhibits characteristic 1H NMR shifts in the aromatic region at δ=7.81−6.90 ppm, indicating a successful functionalization of the polymer. Although this assumption is substantiated by the observation of signals in the 31P NMR spectrum, the presence of at least seven different 31P species, however, points to a low selectivity or the occurrence of side reactions. Still, DOSY-NMR establishes the connection of the aromatic protons to the poly(isoprene) backbone in terms of identical diffusion coefficients and thus a successful functionalization.
Chain-End Functionalization by Activation with Functionalized Mg-Reagents.
The third functionalization strategy targets the introduction of functional groups via the use of functional activation reagents, i.e. organo-magnesium compounds. This functionalization would result in poly(dienes) with polar end groups (Scheme 2).
Scheme 2: Activation of Nd(BH4)3.(THF)3 with functionalized organo-magnesium compounds gives access to chain-end functionalized poly(dienes).
Before we started to assess the potential of this approach towards a possible functionalization of the polymer chain-end, we tested our polymerization conditions in terms of this method's general ability to transfer organic moieties from Mg to Nd and eventually to the chain-end with a non-functionalized alkyl group, i.e. an n-butyl moiety through transfer from MgBu2. The presence of n-butyl end-groups was observed by the appearance of a 1H NMR signal with a shift typical for aliphatic —CH3 groups (δ=0.90 ppm) for all polymerizations in which MgBu2 was used as activation reagent.
A detailed NMR analysis to prove the presence of a butyl group as chain-end was performed for a copolymer synthesized from IP and 3. TOCSY irradiation at the resonance of the CH3 group results in magnetization transfer along the residual butyl chain up to the aliphatic and olefinic signals of the first isoprene unit in the backbone (
Having established the possibility to introduce a chain-end by transferring an organic group from Mg to Nd, we engaged in the synthesis of different polar functionalized organo-Mg compounds (Chart 2).
Chart 2: Polar Functionalized Organo-Magnesium Compounds Used for the Activation of Nd-Based Catalyst Systems.
Polar functionalized organo-Mg compounds Mg-1 to Mg-5 were synthesized by reacting the according Br- or Cl-compound, e.g. Cl—C5H10—SPh for Mg-5, with activated Mg to form the mono-alkyl Mg compound ClMg—C5H10—SPh. The di-alkyl Mg compound Mg(C5H10—SPh)2, Mg-5, was then formed by shifting the Schlenk equilibrium towards MgR2/MgCl2 upon addition of dioxane. Removal of MgX2 gave the desired magnesium compounds Mg-1 to Mg-5 in good to high yields with the saturated species, e.g. C5H11—SPh, as a side product. There is no need, however, to remove the saturated species because they have no adverse influence on the intended use of the synthesized organo-Mg compounds.
Polymerizations with a Nd:diene ratio of ca. 1:100 were performed to assess the general ability of Mg-x (x=1-5) to activate Nd(BH4)3.(THF)3 for the trans-selective diene polymerization. The low Nd:diene ratio was chosen to ensure an end-group to backbone ratio sufficiently high for subsequent NMR analyses. Activation of Nd(BH4)3. (THF)3 was successful with all different polar functionalized organo-Mg compounds. This includes not only the activation by Mg-alkyl compounds (Mg-1, Mg-4, and Mg-5) but also the activation by Mg-aryl compounds (Mg-2 and Mg-3).
Polymerization conditions: Nd(BH4)3.(THF)3:MgR2=1:1, T=60° C. in toluene or C6D6 a) activation efficiency=(funct. groups in polymer in mol %·100−1)·(n(MgR2)·M(diene)·m(polymer)−1)−1 b) determined by 1H NMR b) determined by GPC in THF vs. PS standards. d) determined by 13C NMR e) Nd:MgR=1:1.5 f) not determined because signals of functional groups are (partially) overlapped by backbone signals g) not determined because the low amount of functional groups does not allow for a reliable integration.
13C-NMR shows all obtained polymers to be stereoregular with a high 1,4-trans-content (91-95 mol % trans-units), comparable to the model polymers obtained by activation of Nd(BH4)3.(THF)3 with MgBu2. NMR experiments verify the ability of this approach to generate polar functionalized chain-ends. All obtained polymers exhibit in both, 1H and 13C NMR, characteristic signals for the respective functional group, including pyrrolidine rings for Mg-2, Mg-3, and Mg-4, resonating between δ=2.94 ppm (13C: 47.5 ppm, Mg-2) and 2.38 ppm (13C: 54.1 ppm, Mg-3). In addition, signals for the benzylic protons of Mg-3 (1H: 3.53 ppm, 13C: 61.1 ppm) and (C4H8)N—CH2 group of Mg-4 are found in the respective spectra. In the case of the PhS—CH2— group, introduced by activation with Mg-5, a proton signal at δ=2.67 ppm (13C: 33.3 ppm) suggests functionalization and 1D-TOCSY reveals the connectivity along the residual pentyl-chain to the olefinic signal of the first unit in the PBD backbone. To further prove the chain-end functionalization, i.e. the attachment to the polymer chain, DOSY NMR experiments were performed for all different functional groups (
Chain-end functionalization proceeds efficiently for the obtained polymers. It is known that each activator MgR2 transfers one moiety to the Nd center in the activation step. Moreover, MALDI-TOF analyses of the obtained polymers have proved that all polymer chains bear a chain-end with R-groups derived from the MgR2 used. Under the assumption of quantitative chain-end functionalization, it is possible to determine the activation efficiency of the different Mg-x (Table 2). The activation efficiency is the ratio of the amount of functional groups found in the functionalized polymers to the theoretically expected amount of functionalization expected for quantitative activation of Nd(BH4)3.(THF)3, i.e.
Activation occurs moderately for Mg-3 and Mg-4 with efficiencies between 42 and 58% (Mg-3) and 32 and 42% (Mg-4), respectively. In contrast, excellent activation efficiencies are observed for polymerizations activated with Mg-1 or Mg-5 (92-94%).
The molecular weight distributions are broader in these examples than observed for polymerizations activated with MgBu2, this arises most likely from a slower activation compared to activation by MgBu2 caused by the addition of Mg-x as a solid (the Mg-x used are typically poorly soluble in toluene). Nevertheless, molecular weights comparable to polymerizations activated with MgBu2 can be obtained by adjusting the diene:Nd ratio. Polymerizations with a diene:Nd ratio of 920:1 gave polymers with molecular weights (48 and 57×103 g mol−1) close to the theoretical value (50×103 g mol−1, Table 2, entries 9 and 10).
We have established separately that all three methods to functionalize the synthesized stereoregular poly(dienes) work. Further, it would be highly desirable to combine all three functionalization methods in one polymerization. This could give access to stereoregular, hetero-telechelic poly(dienes) bearing three different functional groups (Scheme 3).
Scheme 3: Combination of three different methods for the introduction of functional groups, thus enabling the synthesis of triple functionalized, hetero-telechelic poly(dienes).
Trifunctional Polymers
Having established the functionalization of both end-groups and of the polymer backbone separately, we studied the combination of all three methods simultaneously to obtain hetero-telechelic, mid-chain functionalized poly(dienes).
As an example of a stereoregular poly(isoprene), the copolymerization of IP and 3 was investigated. The polymerization was activated with Mg-1 (IP:Nd:Mg=100:1:1) and quenched with Si(OEt)4. The obtained polymer is stereoregular with 94% 1,4-trans-units. 1H-NMR shows the presence of TMS-groups (0.19 ppm) and TMS2NCH2-groups (2.84 ppm) indicating a comonomer incorporation of 2.3 mol %. CarbNCH2-groups resonate at 3.83 ppm and the aromatic protons of the carbazyl group are clearly observed (
As an example of a stereoregular poly(butadiene), a copolymerization of BD and 6 (2 mol %) was studied. The polymerization was activated by Mg-5 (BD:Nd:Mg=100:1:1) and quenched with Si(OEt)4 at the end of the reaction. 1H, 13C, and 2D NMR spectroscopy shows the polymer obtained to be stereoregular (94% 1,4-trans-units) and reveals the presence of all three different functional groups (
We have shown in previous work, that the direct copolymerization of functionalized dienes with butadiene or isoprene is feasible with cis-selective Nd-based catalyst systems. It would also be highly desirable for these systems to introduce the possibility of functionalizing chain-ends by activation with functionalized activators. Prior examples of the initiation of cis-selective butadiene polymerizations with magnesium alkyls are scarce. We tested the reported catalyst system (Nd(versatate)3 activated with MgR2 in the presence of ethylaluminium sesquichloride) in polymerizations of butadiene after activation with MgBu2 or Mg-5. Polymerizations activated with MgBu2 showed that the used catalyst system can produce stereoregular poly(butadiene) with a high content of 1,4-cis-units (e.g. 92 mol %). Similarly, a BD polymerization activated with Mg-5 resulted in the formation of stereoregular PBD (86 mol % 1,4-cis-units). Additionally, NMR spectroscopy reveals the presence of functional groups introduced by the activation with Mg-5 as already described above for trans-selective catalyst systems. These results evidence that the introduction of functionalized chain-ends by usage of functionalized activators is also feasible in cis-selective diene polymerization catalyzed by Nd-based catalyst systems.
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