Claims
- 1. A method of manufacturing a porous matrix controlled release drug delivery substance wherein the drug is present in the pores of the matrix comprising the steps of:dispersing, stirring, and emulsifying an aqueous solution containing a water soluble drug in an organic solvent in which a polymer compound and a surface active agent are dissolved in a water-in-oil type emulsion, wherein said surface active-agent is present in the amount of about 0.1 to about 5% wt of the emulsion; thereafter forming the emulsion into a desirable matrix shape; drying at room temperature until the matrix surface is hardened; and vacuum drying to remove water and the organic solvent.
- 2. The method as claimed in claim 1, wherein the polymer compound is selected from the group comprising of poly(l-lactide), poly(dl-lactide), polyglycolide, lactide-glycolide copolymers, poly ortho-ester copolymers, ethylene-vinyl acetate copolymers, and ethylene-vinyl alcohol copolymers.
- 3. The method as claimed in claim 1, wherein the surface-active agent is selected from the group consisting of sorbitan esters and polyoxyethylene sorbitans.
- 4. The method as claimed in claim 1, wherein the drug is a water-soluble drug for oral and non-oral administration that is dissolved in an inner aqueous solution inside the water-in-oil type emulsion.
- 5. The method as claimed in claim 1, wherein the organic solvent is selected from the group comprising of dichloromethane and chloroform.
- 6. The method as claimed in claim 1, wherein the volume ratio of the aqueous solution to the organic solvent is 1:2˜1:40.
Priority Claims (1)
Number |
Date |
Country |
Kind |
96-82443 |
Dec 1997 |
KR |
|
Parent Case Info
This application is a 371 of PCT/KR97/00289, filed on Dec. 31, 1997.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/KR97/00289 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO98/29100 |
7/9/1998 |
WO |
A |
US Referenced Citations (7)
Number |
Name |
Date |
Kind |
4305502 |
Gregory et al. |
Dec 1981 |
A |
4371516 |
Gregory et al. |
Feb 1983 |
A |
4616047 |
Lafon |
Oct 1986 |
A |
4818542 |
DeLuca et al. |
Apr 1989 |
A |
5626861 |
Laurencin et al. |
May 1997 |
A |
5723508 |
Healy et al. |
Mar 1998 |
A |
5942253 |
Gombotz et al. |
Aug 1999 |
A |
Non-Patent Literature Citations (1)
Entry |
Abstract of German Patent DE 2423811 A (1974). |