METHOD OF MODULATING MRNA TRANSLATION

Abstract

Described herein are methods of modulating mRNA translational efficiencies with translational enhancers or silencers that affects ribosomal retention. Also described herein are mRNA molecules including translational enhancers or silencers, as well as modified nucleobases. Also described herein are methods of constructing an mRNA molecule for producing a therapeutic peptide or a therapeutic protein with the identified enhancers.

Description

SEQUENCE LISTING

The ASCII text file named “047162-7374WO1(01839)_Seq Listing.xml” created on Mar. 1, 2023, comprising 1,207,787 bytes, is hereby incorporated by reference in its entirety.

BACKGROUND

The sequences and structures of 5′ untranslated regions (5′ UTRs) of mRNA molecules are known to affect translational efficiencies to a large extent. Specific sequence motifs in the 5′ UTR that increases and decreases translational efficiencies, called translational enhancers and translational silencers, however; remain largely unknown, and high-throughput methods that are able to identify translational enhancers and translational silencers are lacking.

Therefore, there is a need to develop high-throughput screening methods to identify translational enhancers and translational silencers, as well as a need to modulate mRNA translation with the identified enhancers/silencers and to construct mRNA molecules having desirable translational efficiencies. The present invention addresses these needs.

SUMMARY

In some aspects, the present invention is directed to the following non-limiting embodiments: Method of modulating a translational efficiency of mRNA

In some aspects, the present invention is directed to a method of modulating a translational efficiency of a messenger RNA (mRNA) molecule.

In some embodiments the method includes: modifying a 5′-UTR of the mRNA molecule to include a translational enhancer or a translational silencer.

In some embodiments, modifying the 5′-UTR of the mRNA molecule includes modifying a sequence of a DNA molecule encoding the mRNA molecule.

In some embodiments, the translational enhancer or the translational silence is a translational enhancer or a translational silencer for the translational machinery of a yeast species, optionally a yeast species selected from the group consisting of Saccharomyces cerevisiae, Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, Arxula adeninivorans, Kluyveromyces lactis, and Schizosaccharomyces pombe.

In some embodiments, the 5′-UTR of the mRNA molecule is modified to include the translational enhancer, and the translational enhancer includes at least one sequence selected from the group consisting of SEQ ID NOs: 1-3.

In some embodiments, the 5′-UTR of the mRNA molecule is modified to include the translational silencer, and the translational silencer includes at least one sequence selected from the group consisting of SEQ ID NOs: 4-6.

In some embodiments, the translational enhancer or the translational silence is a translational enhancer or a translational silencer for the translational machinery of a mammal, optionally a human.

In some embodiments, the 5′-UTR of the mRNA molecule is modified to include the translational enhancer, and the translational enhancer includes at least one sequence selected from the group consisting of SEQ ID NOs: 7-18, 29-51 and 56-1342.

In some embodiments, the 5′-UTR of the mRNA molecule is modified to include the translational silencer, and wherein the translational silencer includes at least one sequence selected from the group consisting of SEQ ID NOs: 19-28.

In some embodiments, the 5′-UTR of the mRNA molecule is further modified to include a modified nucleobase.

In some embodiments, the modified nucleobase includes N6-methyladenosine, inosine, N1-propylpseudouridine, N1-methoxymethylpseudouridine, N1-ethylpseudouridine, 5-methoxycytidine, 5-hydroxyuridine, 5-carboxyuridine, 5-formyluridine, 5-hydroxycytidine, 5-hyrdoxymethylcytidine, 5-hydroxymethyluridine, 5-formylcytidine, 5-carboxycytidine, N4-methylcytidine, pseudoisocytidine, 2-thiocytidine, 4-thiocytidine, N1-methylpseudouridine, pseudouridine, 5-methyluridine, 5-methoxyuridine, dihydrouridine, 5-methylcytidine, 4-thiouridine, 2-thiouridine, uridine-5′-O-(1-thiophosphate), 5-aminoallyluridine, or 4-acetylcytidine.

In some embodiments, the 5′-UTR of the mRNA molecule is modified to include the translational enhancer, and a ribosome retention score (RRS) of the modified mRNA molecule is 3× or higher than an RRS of the unmodified mRNA molecule.

In some embodiments, the 5′-UTR of the mRNA molecule is modified to include the translational silencer, and wherein a ribosome retention score (RRS) of the modified mRNA molecule is 0.3× or lower than an RRS of the unmodified mRNA molecule.

mRNA Molecule

In some aspects, the present invention is directed to an mRNA molecule.

In some embodiments, the mRNA molecule includes a 5′-UTR, and the 5′-UTR includes: a translational enhancer including at least one sequence selected from the group consisting of SEQ ID NOs: 1-3, 7-18, 29-51 and 56-1342, or a translational silencer including at least one selected from the group consisting of SEQ ID NOs: 4-6 and 19-28; and a modified nucleobase.

In some embodiments, the modified nucleobase includes N6-methyladenosine, inosine, N1-propylpseudouridine, N1-methoxymethylpseudouridine, N1-ethylpseudouridine, 5-methoxycytidine, 5-hydroxyuridine, 5-carboxyuridine, 5-formyluridine, 5-hydroxycytidine, 5-hyrdoxymethylcytidine, 5-hydroxymethyluridine, 5-formylcytidine, 5-carboxycytidine, N4-methylcytidine, pseudoisocytidine, 2-thiocytidine, 4-thiocytidine, N1-methylpseudouridine, pseudouridine, 5-methyluridine, 5-methoxyuridine, dihydrouridine, 5-methylcytidine, 4-thiouridine, 2-thiouridine, uridine-5′-O-(1-thiophosphate), 5-aminoallyluridine, or 4-acetylcytidine.

In some embodiments, the 5′-UTR includes the translational enhancer, and wherein a ribosome retention score (RRS) of the mRNA molecule is 3× or higher than an RRS of an mRNA molecule that does not include the translational enhancer or the modified nucleobase but otherwise has the same sequence.

In some embodiments, the 5′-UTR includes at least one sequences selected from the group consisting of SEQ ID NOs: 29-50.

In some embodiments, the 5′-UTR includes the translational silencer, and wherein an RRS of the mRNA molecule is 0.3× or lower than an RRS of an mRNA molecule that does not include the translational silencer or the modified nucleobase but otherwise has the same sequence.

In some embodiments, the mRNA molecule encodes a therapeutic peptide or a therapeutic protein.

In some embodiments, the therapeutic peptide or the therapeutic protein includes a vaccine.

Method of Constructing an mRNA Molecule

In some aspects, the present invention is directed to a method of constructing an mRNA molecule for producing a therapeutic peptide or a therapeutic protein.

In some embodiments, the method includes a translational enhancer at a 5′ UTR to the 5′ side of a coding region encoding the therapeutic peptide or a therapeutic protein.

In some embodiments the therapeutic peptide or a therapeutic protein includes a vaccine.

Yeast Cell for Expressing Protein

In some aspects, the present invention is directed to a yeast cell for expressing a protein.

In some embodiments, the yeast cell includes an mRNA molecule or a nucleotide encoding the mRNA molecule.

In some embodiments, the mRNA molecule includes: a 5′-UTR including at least one yeast translational enhancer; and a coding region encoding the protein, or a coding region for introducing a nucleotide sequence for encoding the protein.

In some embodiments, the 5′-UTR includes at least one sequence selected from the group consisting of SEQ ID NOs: 1-3.

In some embodiments, the yeast cell is a Saccharomyces cerevisiae cell, a Pichia pastoris cell, a Hansenula polymorpha cell, a Yarrowia lipolytica cell, an Arxula adeninivorans cell, a Kluyveromyces lactis cell, or a Schizosaccharomyces pombe cell.

BRIEF DESCRIPTION OF THE DRAWINGS

The following detailed description of exemplary embodiments will be better understood when read in conjunction with the appended drawings. For the purpose of illustrating, non-limiting embodiments are shown in the drawings. It should be understood, however, that the instant specification is not limited to the precise arrangements and instrumentalities of the embodiments shown in the drawings.

FIGS. 1A-1D demonstrates that DART quantifies 5′-UTR-mediated translational control over a 1,000-fold range, in accordance with some embodiments. FIG. 1A: Different endogenous yeast 5′ UTRs added to a common luciferase coding sequence and 3′ UTR result in large differences in translational output per mRNA in cell lysates. Colored bars represent 5′ UTR isoforms from a single gene. FIG. 1B: Schematic of DNA pool design. All sequences begin with the T7 promoter, followed by ≤122 nts of 5′ UTR sequence, then a minimum of 24 nts of coding sequence, followed by a 10 nt identifier barcode, and finally an RT handle for library preparation. Endogenous 5′ UTR sequences were derived from RNA-seq data. FIG. 1C: DART sequencing overview. FIG. 1D: DART reproducibly measures ribosome recruitment over a 1,000-fold range. Comparison of three DART replicates.

FIGS. 2A-2E demonstrates that the inhibitory RNA features have highly context-dependent effects on initiation, in accordance with some embodiments. FIG. 2A: Design of SL constructs. Two sets of SLs were designed to span a range of folding energies, with the second set scrambling the stem sequences of the first. Stems were inserted into 20 endogenous unstructured 5′ UTRs and positioned every 3 nts. FIG. 2B: Engineered SLs repress RRSs. All stems repress recruitment relative to sequences without an inserted stem, and the strongest stem shows the greatest level of repression, followed by the intermediate stem and the weakest stem. The p value was calculated using Fisher's test, comparing sequences with introduced stems to those without. FIG. 2C: Individual 5′ UTRs show distinct effects of SL insertion. The relative recruitment for the YER003C 5′ UTR with the −12 kcal/mol stem inserted is shown. In this case, the stem is most repressive near the cap and at the start codon. FIG. 2D: An example 5′ UTR from YDR135C showing reduced ribosome recruitment upon mutation of preferred AUGi context nucleotides (−3A, +4G, and +5C). FIG. 2D: Mutations in AUGi context nucleotides cause variable effects on ribosome recruitment, with changes of the −3A being generally the most deleterious. The density plot shows the probability distribution of the relative RRS at each position.

FIGS. 3A-3C demonstrate that eIF4G binding motifs promote translation initiation, in accordance with some embodiments. FIG. 3A: Schematic of eIF4G1 binding to designed 5′ UTR pool including both wild-type oligo(U) motifs and U->CA mutants. FIG. 3B: Violin plots of RRS distributions for 5′ UTRs containing U37, and the matched controls, for three independent replicates. The p values were calculated using Fisher's test. FIG. 3C: Ranked changes in RRSs between oligo(U) 5′ UTRs and matched U->CA mutants. Dots indicate the mean of all replicates that met read coverage thresholds. The minimum and maximum value across the replicates is also depicted. 5′ UTRs with a statistically significant (Bonferroni-corrected two-tailed t test p<0.05) difference between wild-type and mutant variants are shown.

FIGS. 4A-4E demonstrate that DART identifies translational silencers and enhancers within alternative 5′ UTRs, in accordance with some embodiments. FIG. 4A: 5′ UTR isoforms confound the interpretation of averaged ribosome densities observed in coding sequences by ribosome profiling. FIG. 4B: Most alternative 5′ UTR isoforms tested affect ribosome recruitment (RRS). 2,653 isoform pairs differed significantly by >2-fold, 145 differed significantly, but by <2-fold, and 1,332 did not confer significant differences in RRS. The p values were calculated from a Bonferroni-corrected t test. FIG. 4C: Example genes with alternative 5′ UTR isoforms differing in RRS. The long (5′ extended) isoforms of YDL201W, YDR337W, YBR138C, and YLR440C contain putative silencer elements, and the long isoforms of YGL095C, YLR091W, YDR063W, and YGR196C contain putative enhancers. FIG. 4D Violin plots of RRS values from isoform pairs showing differential ribosome recruitment (p<0.05). The additional 5′ sequences included in longer isoforms were used as inputs to identify enriched motifs using DREME. The top two silencing (above) and enhancing (below) motifs are shown. FIG. 4E: ACCAC motifs identified by DART analysis are sufficient to repress translation of full-length mRNAs in vitro (left) and in vivo (right). Translation activity in vivo is normalized to Fluc mRNA levels and total protein.

FIG. 5 illustrates certain aspects of the DART analysis, in accordance with some embodiments.

FIG. 6 lists some resources used in the first study, in accordance with some embodiments.

FIG. 7 shows some exemplary S. cerevisiae 5′ UTR translational enhancers identified with the DART analysis, in accordance with some embodiments.

FIG. 8 shows some exemplary S. cerevisiae 5′ UTR translational silencers identified with the DART analysis, in accordance with some embodiments.

FIGS. 9A-9B demonstrate that ribosome recruitment scores of the human 5′ UTR sequences obtained using the DART analysis are highly reproducible, in accordance with some embodiments. FIG. 9A: 5′ UTRs with unmodified nucleotides. FIG. 9B: 5′ UTRs modified with N1-methylpseudouridine (m1Ψ).

FIGS. 10A-10B demonstrate that the incorporation of N1-methylpseudouridine (m1Psi) into human 5′UTRs alters ribosome recruitment, in accordance with some embodiments.

FIGS. 11A-11B shows some exemplary human translational silencer and enhancer sequences, in accordance with some embodiments. FIG. 11A: Enhancers. FIG. 11B: Silencers.

FIGS. 12A-12B show that the screening method according to some embodiments herein identified thousands of short 5′-UTRs that outperform current class (e.g., those used by Moderna or Pfizer in mRNA-based vaccines). FIG. 12A: pool 1, 100 nucleotides to 230 nucleotides. FIG. 12B: pool 2, 10 nucleotides to 100 nucleotides.

FIG. 13 demonstrates that the m1Ψ sensitivity of translational efficiency is driven by the 5′-UTR, in accordance with some embodiments. The data show that the observed effects of m1Ψ on ribosome recruitment are driven by incorporation into the 5′ UTR and not the coding sequence. The same 5′-UTR sequence (in this case, the Moderna sequence) was testing with 3 different coding sequence segments in DART. Regardless of the coding sequence used, m1Ψ increases recruitment to this RNA.

FIG. 14 shows that that the screening method according to some embodiments herein identified thousands of short 5′-UTRs that outperform current class (e.g., those used by Moderna or Pfizer in mRNA-based vaccines).

FIG. 15: non-limiting examples of modified nucleotides that are compatible with the screening method herein. The present study validated that the modifications shown in FIG. 15 are compatible with the screening method herein. Top: N1-methylpseudouridine, pseudouridine, 5-methyluridine, 5-methoxyuridine, dihydrouridine, 5-methylcytidine, Bottom: 4-thiouridine, 2-thiouridine, uridine-5′-O-(1-thiophosphate), 5-aminoallyluridine, 4-acetylcytidine.

FIG. 16: systematic identification of regulatory elements, in accordance with some embodiments. FIG. 16 describes a variation of the screening method herein in a systematic manner. Here, the present study took the 100 best and 100 worst sequences and generated variants with scanning, non-overlapping 6 nucleotide deletions across the UTR sequence (over 6,000 variants). This pool was then subjected to the screening method herein. Putative regulatory sequences (enhancers or repressors) were identified by comparing the ribosome recruitment scores of the deletion variants to that of the parent UTR sequence.

FIG. 17 shows an example of the screening method according to FIG. 16. The present study identified a possible translation-enhancing element in an individual 5′ UTR. The top graph shows the log 2RRS for each variant, bottom shows the fold change in RRS compared to the parental sequence. Deletion of nucleotides 1-6 and 7-12 causes a significant decrease in ribosome recruitment to this sequence.

FIGS. 18A-18C: a non-limiting screen method according to some embodiments (DART) quantifies 200-fold differences in 5′ UTR-mediated ribosome recruitment that predicts protein synthesis in vitro and in cells. FIG. 18A: Schematic of the DART workflow. The sequences in the DNA pool begin with a T7 promoter followed by >27nt of common GFP coding sequence and an RT handle for library preparation. Endogenous 5′ UTR sequences were derived from Ensembl annotations. FIG. 18B: DART reproducibly measures ribosome recruitment of a 200-fold range. Comparison of three DART replicates. FIG. 18C: Ribosome recruitment scores predict 5′ UTR-driven translational activity in full-length mRNAs in vitro (Hela cytoplasmic lysate, middle) and in cells (Hela cell transfection, lower).

FIGS. 19A-19H: a non-limiting screen method according to some embodiments (DART) quantifies the regulatory impact of 5′ UTR length, secondary structure, Kozak context, and alternative isoform usage. FIG. 19A: 5′ UTR length is significantly anticorrelated with ribosome recruitment. Correlation plot of UTR length versus ribosome recruitment scores. FIG. 19B: The correlation of 5′ UTR length on activity is driven by sequences shorter than 80 nucleotides. 5′ UTRs were combined into increasing 10 nucleotide-length bins and plotted against RRS. RRS steadily decreases as 5′ UTR length increases until leveling off above 80 nucleotides. FIG. 19C: DART analysis of 11,000 5′ UTRs ranging from 100-230 nucleotides long demonstrates negligible correlation between UTR length and ribosome recruitment. FIG. 19D: Secondary structure has a moderate activity on ribosome recruitment activity. In silico predicted free energy of folding for each UTR is plotted against its RRS score. FIG. 19E: Top- and bottom-scoring 5′ UTRs show no meaningful difference in their Kozak sequence composition. Plots show the nucleotide composition of ten nucleotides upstream of the start codon for the top 25% (left, n=4937) and bottom 25% (right, n=4937) 5′ UTR sequences. FIG. 19F: Kozak sequence optimality has no impact on ribosome recruitment activity. Per-sequence Kozak scores were determined using TIS-Predictor. UTRs with the most optimal Kozak sequence (“Top 25%”) show no significant difference compared to the middle 50% or worst 25%. FIG. 19G: The majority of 5′ UTR isoform pairs exhibit significantly different ribosome recruitment activity. 8,109 isoform pairs differed significantly by >2-fold (red), 9,788 differed significantly, but by <2-fold, and 5,058 did not exhibit significant differences in RRS. FIG. 19H: Example genes with alternative 5′ UTR isoforms with large differences in RRS. The shorter isoforms of RBPJ and SYNGR3 show significantly higher activity than the longer isoforms, while the longer isoforms of SEPTIN9 and SLC12A9 are more active than their shorter isoforms.

FIGS. 20A-20D: N1-methylpseudouridine incorporation into 5′ UTRs significantly alters ribosome recruitment, in accordance with some embodiments. FIG. 20A: Replicates of uridine (left)- and N1-methypseuoduridine (m1Ψ, right)-containing 5′ UTRs exhibit strong correlation, while comparing identical sequences containing uridine versus m1Ψ (middle) reveals significant differences. The RRS scores plotted are an average of six replicates (error bars=S.D.). FIG. 20B: The impact of m1Ψ on ribosome recruitment is context dependent. 1,404 5′ UTRs exhibit significantly reduced ribosome recruitment when uridine is replaced with m1Y (right side; fold change >2, Benjamini-Hochberg adjusted p<0.01), while 2,600 5′ UTRs show significantly increased ribosome recruitment with m1Y (left side; fold change >2, Benjamini-Hochberg adjusted p<0.01). FIGS. 20C-20D: Single substitutions of uridine with m1Ψ can significantly impact ribosome recruitment activity both negatively (FIG. 20C, 6.8-fold decrease, p<0.0001), and positively (FIG. 20D, 4.24-fold increase, p<0.0001).

FIGS. 21A-21G: CCC motifs are a novel translational repressor, in accordance with some embodiments. FIG. 21A: Increasing cytidine content significantly represses ribosome recruitment. 5′ UTRs were binned according to their percent cytidine. FIG. 21B: C-rich sequences are enriched in poor-recruiting 5′ UTRs. The poorest 10% of recruiters were used as inputs for motif enrichment using DREME. 3 out of the top 5 motifs contain a CCC trinucleotide element. FIG. 21C: The presence of CCC motifs correlates with decreased ribosome recruitment. 5′ UTRs containing 30-35% cytidine were selected to hold overall cytidine constant. These UTRs were then binned based on the number of CCC motifs they contain. The data are represented as mean RRS for each bin (error bars=S.D.). FIGS. 21D-21E: CCC motifs are sufficient to repress ribosome recruitment in a dose-dependent manner. CCC sequences were iteratively added to 5′ UTRs and these UTRs were then subjected to DART analysis. The dose-dependent repressive effect is displayed for the 5′ UTR of ZFPL1 (FIG. 21D) and across all UTRs tested (FIG. 21E, n=225 parent 5′ UTRs, 1350 total variants). FIG. 21F: CCC motifs identified by DART are sufficient to repress translation in full-length mRNAs. FIGS. 21G-21H Removal of CCC motifs from human 5′ UTRs increases ribosome recruitment. CCC motifs were iteratively deleted from 5′ UTRs and these were subjected to DART analysis. The effect of successive CCC removal is demonstrated for the 5′ UTR of POC1B (FIG. 21G) and across all UTRs tested (FIG. 21H, n=225 parent 5′ UTRs, 1350 total variants).

DETAILED DESCRIPTION

The following disclosure provides many different embodiments, or examples, for implementing different features of the provided subject matter. Specific examples of components and arrangements are described below to simplify the present disclosure. These are, of course, merely examples and are not intended to be limiting. For example, the formation of a first feature over or on a second feature in the description that follows may include embodiments in which the first and second features are formed in direct contact, and may also include embodiments in which additional features may be formed between the first and second features, such that the first and second features may not be in direct contact. In addition, the present disclosure may repeat reference numerals and/or letters in the various examples. This repetition is for the purpose of simplicity and clarity and does not in itself dictate a relationship between the various embodiments and/or configurations discussed.

In the first study described herein (“the first study”), a method capable of identifying translational enhancers and translational silencers in the 5′ untranslated regions (5′ UTRs) of mRNA molecules was developed. Specifically, in the first study, a library of mRNA molecules having similar coding regions but different 5′ UTR sequences were mixed with 80s ribosomes to form complexes. The complexes in the mixture were stabilized with cycloheximide and the mixture were then subjected to density gradient fractionation to isolate the ribosome-mRNA complexes and the mRNA. The ribosomal recruitment efficiencies of the 5′ untranslated regions were determined according to the relative abundances of the mRNA molecules in the complex.

In the second study described herein (“the second study”), using the method developed in the first study, translational enhancers and translational silencers in the 5′ UTR were determined in the budding yeast.

In the third study described herein (“the third study”), using the method developed in the first study, translational enhancers and translational silencers in the 5′ UTR were determined in humans.

Accordingly, in some aspects, the present invention is directed to a method of modulating a translational efficiency of a messenger RNA (mRNA) molecule.

In some aspects, the present invention is directed to a non-naturally occurring mRNA molecule. In some embodiments, the non-naturally occurring mRNA molecule has increased or decreased translational efficiencies in comparison to similar naturally occurring mRNA molecules.

In some embodiments, the present invention is directed to a method of constructing mRNA molecules for producing therapeutic proteins/peptide.

Definitions

As used herein, each of the following terms has the meaning associated with it in this section. Unless defined otherwise, all technical and scientific terms used herein generally have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Generally, the nomenclature used herein and the laboratory procedures in animal pharmacology, pharmaceutical science, peptide chemistry, and organic chemistry are those well-known and commonly employed in the art. It should be understood that the order of steps or order for performing certain actions is immaterial, so long as the present teachings remain operable. Any use of section headings is intended to aid reading of the document and is not to be interpreted as limiting; information that is relevant to a section heading may occur within or outside of that particular section. All publications, patents, and patent documents referred to in this document are incorporated by reference herein in their entirety, as though individually incorporated by reference.

In the application, where an element or component is said to be included in and/or selected from a list of recited elements or components, it should be understood that the element or component can be any one of the recited elements or components and can be selected from a group consisting of two or more of the recited elements or components.

In the methods described herein, the acts can be carried out in any order, except when a temporal or operational sequence is explicitly recited. Furthermore, specified acts can be carried out concurrently unless explicit claim language recites that they be carried out separately. For example, a claimed act of doing X and a claimed act of doing Y can be conducted simultaneously within a single operation, and the resulting process will fall within the literal scope of the claimed process.

In this document, the terms “a,” “an,” or “the” are used to include one or more than one unless the context clearly dictates otherwise. The term “or” is used to refer to a nonexclusive “or” unless otherwise indicated. The statement “at least one of A and B” or “at least one of A or B” has the same meaning as “A, B, or A and B.”

“About” as used herein when referring to a measurable value such as an amount, a temporal duration, and the like, is meant to encompass variations of 20% or +10%, in certain embodiments ±5%, in certain embodiments 10%, in certain embodiments ±0.1% from the specified value, as such variations are appropriate to perform the disclosed methods.

Method of Identifying Translational Enhancers and/or Translational Silencers in 5′ UTRs of mRNA Molecules

In some embodiments, the instant specification is directed to a method of identifying translational enhancers and/or translational silencers in 5′ untranslated regions (5′ UTRs) of mRNA molecules.

In some embodiments, the method includes: preparing a plurality of mRNA molecules, wherein each mRNA molecules including a 5′ UTR and a coding region to the 3′ end of the 5′ UTR; contacting the plurality of mRNA molecules with a ribosome; isolating the ribosome; and

• • determining sequences of 5′ UTRs of mRNA molecules in complex with the isolated ribosomes.

In some embodiments, the 5′ UTRs of an mRNA molecule includes a translational enhancer if the mRNA molecule is more likely to be found in complex with the isolated ribosomes than average.

In some embodiments, the 5′ UTRs of an mRNA molecule includes a translational silencer if the mRNA molecule is less likely to be found in complex with the isolated ribosomes than average.

In some embodiments, the method further includes identifying one or more translational enhancers by determining one or more sequence motifs commonly found in 5′ UTRs of mRNA molecules that are more likely to be found in complex with the isolated ribosomes than average; or identifying one or more translational silencers by determining one or more sequence motifs commonly found in 5′ UTRs of mRNA molecules that are less likely to be found in complex with the isolated ribosomes than average.

In some embodiments, the plurality of mRNA molecules has the same sequence in the coding region. In some embodiments, the coding regions of the plurality of mRNA molecules have similar sequences. In some embodiments, the coding regions of the plurality of mRNA molecules affect translational efficiency at similar levels.

In some embodiments, isolating the ribosomes includes isolation according to the sedimentation coefficient of the ribosome.

In some embodiments, the ribosomes are isolated by density gradient fractionation.

In some embodiments, contacting the plurality of mRNA molecules with the ribosomes includes stabilizing complexes formed by mRNA molecules and ribosomes.

In some embodiments, stabilizing the complexes includes contacting the complexes with cycloheximide.

In some embodiments, the method includes calculating a ribosome retention score based on the relative abundance of the mRNA ribosome complex. As used herein, the term ribosome retention score or RRS refers to a numeric descriptor of the ability of a particular mRNA 5′ UTR to promote ribosome binding and thus translation of the 3′ coding region of the mRNA. The attached appendices describe non-limiting examples of methods for determining an RRS.

In some embodiments, the ribosome retention score mRNA molecules in complex with the isolated ribosomes is calculated based on the relative abundance of the mRNA molecule isolated in complex with ribosomes in comparison to an abundance of the mRNA molecule in the input pool.

In some embodiments, the ribosome retention score of an mRNA molecule in complex with the isolated ribosomes is calculated according to a relative abundance the mRNA molecule isolated in complex with ribosome in comparison to a sum of an abundance of the mRNA molecule isolated in complex with ribosome and an abundance of the mRNA molecule isolated without forming complex with ribosome.

In some embodiments, determining the sequences of 5′ UTRs of mRNA molecules includes sequencing the 5′ UTRs.

In some embodiments, the plurality of mRNA molecules further includes barcoding sequences.

In some embodiments, the barcoding sequences correspond to the sequences of the 5′ UTRs.

In some embodiments, determining the sequences of 5′ UTRs of mRNA molecules includes identifying the barcoding sequences of the mRNA molecules.

In some embodiments, the method further includes verifying the identified 5′ UTR translational enhancers and/or translational silencers.

In some embodiments, verifying the identified 5′ UTR translational enhancers and/or translational silencers includes constructing a first mRNA molecule including a first 5′ UTR and a coding region encoding a reporter protein.

In some embodiments, the first 5′ UTR includes the identified translational enhancers and/or translational silencers; constructing a second mRNA molecule including a second 5′ UTR and the coding region encoding the reporter protein.

In some embodiments, the second 5′ UTR does not include the identified translational enhancers and/or translational silencers, but is otherwise the same as the first 5′ UTR.

In some embodiments, verifying the identified 5′ UTR translational enhancers and/or translational silencers further includes contacting the first mRNA molecule and the second mRNA molecule with ribosome.

In some embodiments, verifying the identified 5′ UTR translational enhancers and/or translational silencers further includes measuring a first level of reporter signal from the translation of the first mRNA molecule.

In some embodiments, verifying the identified 5′ UTR translational enhancers and/or translational silencers further includes measuring a second level of reporter signal from the translation of the second mRNA molecule.

In some embodiments, verifying the identified 5′ UTR translational enhancers and/or translational silencers further includes comparing the first level and the second level.

Method of Modulating Translational Efficiency of mRNA Molecules

In some aspects, the present invention is directed to a method of modulating a translational efficiency of an mRNA molecule.

In some embodiments, the method includes modifying a 5′-UTR of the mRNA molecule to include a translational enhancer or a translational silencer.

In some embodiments, modifying the 5′-UTR of the mRNA molecule includes modifying a sequence of a DNA molecule encoding the mRNA molecule.

In some embodiments, the translational enhancer or the translational silence is a translational enhancer or a translational silencer for the translational machinery of yeasts. It is worth noting that, although the working examples described herein were tested in Saccharomyces cerevisiae, since the translation machinery is highly conserved among yeast species, the translational enhancers or translational silencers identified in Saccharomyces cerevisiae are expected to work in yeast in general. In some embodiments, the translational enhancer or the translational silence is a translational enhancer or a translational silencer for the translational machinery of Saccharomyces cerevisiae, Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, Arxula adeninivorans, Kluyveromyces lactis, or Schizosaccharomyces pombe.

In some embodiments, the 5′-UTR of the mRNA molecule is modified to include the translational enhancer, and wherein the translational enhancer includes at least one sequence selected from the group consisting of SEQ ID NOs: 1-3.

In some embodiments, the 5′-UTR of the mRNA molecule is modified to include the translational silencer, and wherein the translational silencer includes at least one sequence selected from the group consisting of SEQ ID NOs: 4-6.

In some embodiments, the translational enhancer or the translational silence is a translational enhancer or a translational silencer for the translational machinery of a mammal, such as a human. It is worth noting that, although the working examples described herein were tested in human cells, the translational machinery among mammals are conserved. As such, translational enhancer and translational silencers identified for humans are expected to work in other mammals.

In some embodiments, the 5′-UTR of the mRNA molecule is modified to include the translational enhancer, and wherein the translational enhancer includes at least one sequence selected from the group consisting of SEQ ID NOs: 7-18, 29-51, and 56-1342.

In some embodiments, the 5′-UTR of the mRNA molecule is modified to include the translational silencer, and wherein the translational silencer includes at least one sequence selected from the group consisting of SEQ ID NOs: 19-28.

In some embodiments, the 5′-UTR of the mRNA molecule is further modified to include a modified nucleobase. In some embodiments, the modified nucleobase includes N6-methyladenosine, inosine, N1-propylpseudouridine, N1-methoxymethylpseudouridine, N1-ethylpseudouridine, 5-methoxycytidine, 5-hydroxyuridine, 5-carboxyuridine, 5-formyluridine, 5-hydroxycytidine, 5-hyrdoxymethylcytidine, 5-hydroxymethyluridine, 5-formylcytidine, 5-carboxycytidine, N4-methylcytidine, pseudoisocytidine, 2-thiocytidine, 4-thiocytidine, N1-methylpseudouridine, pseudouridine, 5-methyluridine, 5-methoxyuridine, dihydrouridine, 5-methylcytidine, 4-thiouridine, 2-thiouridine, uridine-5′-O-(1-thiophosphate), 5-aminoallyluridine, or 4-acetylcytidine.

In some embodiments, the 5′-UTR of the mRNA molecule is modified to include the translational enhancer, and wherein a ribosome retention score (RRS) of the modified mRNA molecule is 2× or higher, such as 3× or higher, 10× or higher, 100× or higher or 1000× or higher, than an RRS of the unmodified mRNA molecule.

In some embodiments, the 5′-UTR of the mRNA molecule is modified to include the translational silencer, and wherein a ribosome retention score (RRS) of the modified mRNA molecule is 0.5× or lower, such 0.3× or lower, 0.1× or lower, 0.0 × or lower or 0.00 × or lower, than an RRS of the unmodified mRNA molecule.

In some embodiments, the 5′-UTR is modified to include the translational enhancer and a modified nucleobase that is able to enhance translation. In some embodiments, the 5′-UTR is modified to include the translational silencer and a modified nucleobase that is able to suppress translation. Whether a modified nucleobase in the 5′-UTR enhances or suppresses translation of an mRNA molecule is context dependent (i.e., a modified nucleobase that enhances translation in one position of one 5′UTR sequence might suppress translation if placed in another position, or in another 5′UTR sequence).

mRNA Molecule

In some embodiments, the present invention is directed to an mRNA molecule.

In some embodiments, the mRNA molecule does not exist in the nature. In some embodiments, the mRNA molecule does not exist in the nature because the mRNA molecule includes a modified nucleobase. As used herein, the term “modified nucleobase” refers to nucleobases other than the four common nucleobases adenine (A), cytosine (C), uracil (U), and guanine (G). The term “modified nucleobase” does not exclude naturally occurring nucleobases that are found in non-mRNA molecules. For example, nucleobases like pseudouridine, 5-methylcytosine, N1-methylpseudouridine and 2′-O-methylated exist in nature. These nucleobases are considered to be examples of modified nucleobases herein.

In some embodiments, the mRNA molecule includes a 5′-UTR.

In some embodiments, the 5′-UTR includes:

• • a translational enhancer including at least one sequence selected from the group consisting of SEQ ID NOs: 1-3, 7-18, 29-51, and 56-1342, or a translational silencer including at least one selected from the group consisting of SEQ ID NOs: 4-6 and 19-28; and
  • a modified nucleobase.

In some embodiments, the modified nucleobase is the nucleobases of N6-methyladenosine, inosine, N1-propylpseudouridine, N1-methoxymethylpseudouridine, N1-ethylpseudouridine, 5-methoxycytidine, 5-hydroxyuridine, 5-carboxyuridine, 5-formyluridine, 5-hydroxycytidine, 5-hyrdoxymethylcytidine, 5-hydroxymethyluridine, 5-formylcytidine, 5-carboxycytidine, N4-methylcytidine, pseudoisocytidine, 2-thiocytidine, 4-thiocytidine, N1-methylpseudouridine, pseudouridine, 5-methyluridine, 5-methoxyuridine, dihydrouridine, 5-methylcytidine, 4-thiouridine, 2-thiouridine, uridine-5′-O-(1-thiophosphate), 5-aminoallyluridine, or 4-acetylcytidine.

In some embodiments, the 5′-UTR includes the translational enhancer, and the modified nucleobase is able to enhance translation. In some embodiments, the 5′-UTR includes the translational silencer, and the modified nucleobase is able to suppress translation.

In some embodiments, the 5′-UTR includes the translational enhancer. In some embodiments, a ribosome retention score (RRS) of the mRNA molecule is 2× or higher, such as 3× or higher, 10× or higher, 100× or higher or 1000× or higher, than an RRS of an mRNA molecule that does not include the translational enhancer or the modified nucleobase but otherwise has the same sequence.

In some embodiments, the 5′-UTR includes the translational silencer. In some embodiments, an RRS of the mRNA molecule is 0.5× or lower, such as 0.3× or lower, 0.1× or lower, 0.01× or lower or 0.001× or lower, than an RRS of an mRNA molecule that does not include the translational silencer or the modified nucleobase but otherwise has the same sequence.

In some embodiments, the mRNA molecule encodes a therapeutic peptide or a therapeutic protein.

In some embodiments, the therapeutic peptide or the therapeutic protein includes a vaccine.

Method of Constructing mRNA Molecules for Producing Therapeutic Protein/Peptide

In some embodiments, the present invention is directed to a method of constructing an mRNA molecule for producing a therapeutic peptide or a therapeutic protein.

In some embodiments, the method includes including a translational enhancer at a 5′ UTR to the 5′ side of a coding region encoding the therapeutic peptide or a therapeutic protein.

In some embodiments, the therapeutic peptide or a therapeutic protein includes a vaccine.

Yeast Cell for Expressing Protein

In some embodiments, the present invention is directed to a yeast cell, such as a yeast cell for expressing a protein. In some embodiments, the yeast cell is a bioengineered yeast cell. In some embodiments, the protein to be expressed by the yeast cell is a protein exogenous or endogenous to the yeast cell. In some embodiments, the protein is a secreted protein.

In some embodiments, the yeast cell is a recombinant yeast cell having a sequence encoding a 5′-UTR translational enhancer engineered into either the genomic DNA or a plasmid/expression vector.

In some embodiments, the nucleic acid encoding the protein to be expressed is already in the yeast cell and is located downstream of the 5′-UTR translational enhancer such that the expression of the protein is enhanced by the 5′-UTR translational enhancer. In some embodiments, the nucleic acid encoding the protein to be expressed has not been engineered into the yeast cell, such that any desired nucleic acid sequences for encoding a protein can be placed downstream of the 5′-UTR translational enhancer.

In some embodiments, the 5′-UTR translational enhancers for yeasts are the same as or similar to those as detailed elsewhere herein.

In some embodiments, the yeast cell is Saccharomyces cerevisiae, Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, Arxula adeninivorans, Kluyveromyces lactis, or Schizosaccharomyces pombe.

EXAMPLES

The instant specification further describes in detail by reference to the following experimental examples. These examples are provided for purposes of illustration only, and are not intended to be limiting unless so specified. Thus, the instant specification should in no way be construed as being limited to the following examples, but rather, should be construed to encompass any and all variations which become evident as a result of the teaching provided herein.

Example 1

In the study described in Example 1 (“the first study”), a method to quantify translation initiation on thousands of 5′ UTRs in parallel was developed. The first study uncovered sequence-specific motifs that control translation by varied mechanisms and establish a platform for systematic interrogation of 5′ UTR variants that can be used to engineer mRNAs for optimized protein output.

Translational control shapes the proteome in normal and pathophysiological conditions. Current high-throughput approaches reveal large differences in mRNA-specific translation activity but cannot identify the causative mRNA features. The first study developed direct analysis of ribosome targeting (DART) and used it to dissect regulatory elements within 5′ untranslated regions that confer 1,000-fold differences in ribosome recruitment in biochemically accessible cell lysates. Using DART, the first study determined a functional role for most alternative 5′ UTR isoforms expressed in yeast, revealed a general mode of increased translation via direct binding to a core translation factor, and identified numerous translational control elements including C-rich silencers that are sufficient to repress translation both in vitro and in vivo. DART enables systematic assessment of the translational regulatory potential of 5′ UTR variants, whether native or disease-associated, and will facilitate engineering of mRNAs for optimized protein production in various systems.

Example 1-1: Related Information

Translation initiation is an important step in eukaryotic gene expression, the dysregulation of which is linked to heritable human diseases and cancer. Systematic characterization has shown that mRNA-specific translational activity varies by orders of magnitude under normal growth conditions and is extensively regulated in response to a wide range of physiological signals. Despite growing interest in the mRNA features responsible for this widespread translational control, current high-throughput methods, which rely on quantification of the average number of translating ribosomes per transcript, have revealed only partial correlations (R=0.3-0.8) that leave many differences in translation activity unexplained. In contrast, in-depth genetic and biochemical analysis has revealed detailed regulatory mechanisms for certain mRNAs.

Genome-wide association studies (GWASs) show diverse disease phenotypes associated with non-coding single-nucleotide polymorphisms (SNPs) found within 5′ UTRs. However, current efforts to identify causal variants, which are potential targets for new therapies, are largely restricted to non-synonymous changes within protein coding sequences. A richer understanding of mRNA sequence-specific translation mechanisms is needed to predict which 5′ UTR variants are likely to do damage by dysregulating protein levels. The first study developed direct analysis of ribosome targeting (DART) technology as a bridge between high-throughput, but mechanistically difficult to parse, in vivo approaches and mechanistically precise, but low-throughput, in vitro translation reconstitution assays. In DART, thousands of synthetic mRNAs initiate translation in vitro. Differential abundance analysis of ribosome-bound and input mRNA reveals differences in translation activity. By massively parallel testing of defined sequences, both endogenous and mutated, the approach moves beyond correlation analysis to enable rapid, hypothesis-driven dissection of the causative role of specific 5′ UTR elements to determine their mechanisms of action.

Here, the first study demonstrates the broad power of DART to illuminate the mechanisms underlying translational control. Overall, the first study tested 4,354 full-length alternative mRNA isoforms from 2,064 yeast genes, which revealed widespread translational control by alternative 5′ UTRs. The first study also exploited the throughput of the DART approach to systematically interrogate the effects of RNA secondary structure, start codon context, and protein binding motifs on translation initiation. The results establish a broad stimulatory role for eIF4G1 binding sequences and also demonstrate highly context-dependent control by inhibitory 5′ UTR structures. This illustrates the potential of DART to illuminate the function of putative RNA regulatory elements identified by other high-throughput approaches. The first study further leveraged the alternative 5′ UTR isoform comparisons to discover hundreds of previously uncharacterized translational enhancers and silencers, short sequence elements that are sufficient to promote or repress ribosome recruitment. The study validated several C-rich silencers as sufficient to repress translation both in vitro and in vivo. Together, the results reveal thousands of previously unidentified functional elements within 5′ UTRs that substantially affect translation. This study establishes DART as a powerful new high-throughput method that can be broadly applied to both discover and interrogate regulatory features within 5′ UTRs.

Example 1-2: Development of DART for Quantitative Comparison of Translation Initiation

5′ UTRs directly contact the translation initiation machinery and can strongly influence translation activity (FIG. 1A), but the features that distinguish efficiently translated mRNAs are largely unknown. The first study developed DART as a high-throughput method to enable rapid determination of the role of individual regulatory elements within 5′ UTRs. The first study designed a library of DNA oligonucleotides (oligos), based on deep sequencing of yeast mRNA isoforms (Pelechano et al., 2014) (STAR Methods), that included 12,000 sequences corresponding to the full-length 5′ UTR sequences from 4,252 genes. This pool design focuses on identifying functional elements within endogenous 5′ UTRs, in contrast to complementary studies that interrogate random sequences. The library covers 68% of genes expressed during exponential growth and includes alternative mRNA isoforms for many genes. A common (5′) T7 promoter and a (3′) priming site for reverse transcription flanked each unique mRNA sequence. The 5′ UTR sequence was extended to include at least 24 nucleotides of endogenous coding sequence to preserve potentially important downstream sequences that are protected by initiating ribosomes. Each oligo also included a unique 10 nt barcode to distinguish closely related sequences (FIG. 1B).

Next, the first study used these designed pools to generate dsDNA templates for in vitro transcription, followed by enzymatic mRNA capping to produce the pooled RNA substrates for in vitro translation initiation. RNAs were enzymatically biotinylated at their 3′ ends to facilitate quantitative recovery. RNA pools were incubated in yeast translation extracts (Gilbert et al., 2007; Hodgman and Jewett, 2013; Iizuka et al., 1994) for 30 min, a time point that maximizes quantitative differences in ribosome recruitment between 5′ UTRs while yielding enough initiated mRNA for robust library preparation. Cycloheximide was included in the translation reaction to freeze recruited ribosomes at initiation codons and prevent ribosome run-off during ultracentrifugation to separate 80S ribosome-mRNA complexes from untranslated mRNAs. Ribosome-bound mRNA was isolated and sequenced, and the relative abundance of each sequence was compared to its abundance in the input pool to determine a ribosome recruitment score (RRS) for each 5′ UTR (FIG. 1C). DART revealed up to 1,000-fold differences in ribosome recruitment that were highly reproducible (R2=0.94-0.95) among three independent replicates (FIG. 1D). Six 5′ UTRs were selected for low-throughput validation and observed good agreement with DART measurements. Thus, the first study established a robust method to determine the translation initiation activity of defined 5′ UTR sequences.

A caveat to the 80S/input calculation used to assess translation initiation activity is that sequences that destabilize 5′ UTRs in extracts could also lead to a reduction in 80S-bound RNA compared to the input pool. The first study therefore tested an alternative method of calculating RRSs by sequencing the untranslated mRNA from the top of the gradient in addition to the 80S fraction, using the formula RRS0=80S/(80S+mRNP). These two metrics, RRS and RRS0, produced correlated, but not identical, results (R=0.61; p<2.2e-16). Notably, each of the main conclusions reported below is consistent between calculation methods. Because changes in translation initiation can indirectly affect mRNA levels, the 80S/input calculation (RRS) is preferred.

Example 1-3: A Broad Stimulatory Role for Initiation Factor Binding Motifs in 5′ UTRs

It was hypothesized that 5′ UTR elements that bind preferentially to eukaryotic initiation factors (eIFs) may function as translational enhancers. Consistent with this model, diverse viruses rely on high-affinity interactions between their 5′ UTRs and cellular initiation factors and/or ribosomes for efficient translation. The eIF4G subunit of the cap binding complex is a prime candidate to mediate the activity of translational enhancer sequences. eIF4G contains three RNA binding domains that directly interact with mRNA and are essential for yeast growth, although specific functional interactions between eIF4G and cellular mRNAs had not been characterized. A high-throughput approach, RNA Bind-n-Seq (RBNS), was used to interrogate the RNA binding specificity of eIF4G1. Using a library of random 20-mer RNA to test ˜87,380 distinct RNA 7-mer motifs for binding to different concentrations of recombinant eIF4G1, the first study uncovered a preference for RNA sequences containing oligo-uridine (U). Consistently, it was found that inserting oligo(U) into an unstructured RNA increased binding to eIF4G1 by 20-fold.

Here, the first study sought to comprehensively test the impact of endogenous oligo(U) motifs on translation initiation. Hundreds of native yeast 5′ UTRs contain oligo(U) sequences, which are evolutionarily conserved among budding yeast species and enriched in genes with regulatory roles. The first synthesized a pool of capped mRNAs consisting of all yeast 5′ UTR sequences ≤94 nt long that contain U³7 (168 in total), together with their start codons and some coding sequence. The pool included matched controls for each 5′ UTR in which the oligo(U) motif was replaced with a CA repeat of equal length (FIG. 3A). The first study performed DART on these native 5′ UTR sequences and compared their activity with and without their endogenous oligo(U) motifs. In all three replicates, wild-type oligo(U)-containing mRNAs were recruited more efficiently to the ribosomal fraction than their matched mutant counterparts (FIG. 3B). Of the 5′ UTR sequences whose ribosome recruitment differed significantly (p<0.05 by two-tailed paired t test) between the wild-type and mutant variants, all were recruited better with the oligo(U) motif present (FIG. 3C). These results are consistent with and substantially extend previous low-throughput experiments that showed endogenous 5′ UTR oligo(U) motifs stimulated translation of full-length mRNA in yeast lysates. The results reveal a broad stimulatory role for eIF4G binding motifs within yeast 5′ UTRs and illustrate the power of DART to assess the function of putative RNA regulatory elements identified by other high-throughput approaches.

Example 1-4: Production of Alternative 5′ UTR Isoforms Generally Affects Translation Activity

Many eukaryotic genes express multiple mRNA isoforms that differ in their 5′ UTRs, which complicates the analysis of ribosome profiling data to identify translational control elements. Because ribosome-protected footprints within coding sequences cannot be correctly assigned to translation initiation by specific 5 UTRs, the mRNA-specific translational efficiency inferred from ribosome profiling data may not accurately reflect the actual translation activity of any mRNA isoform (FIG. 4A). DART was therefore used to directly compare the activity of expressed alternative mRNA isoforms whose 5′ UTRs differ by at least 10 nucleotides.

The first study analyzed RNA sequencing (RNA-seq) data from wild-type yeast (STAR Methods) and identified 4,354 alternative mRNA isoforms expressed from 2,064 genes that we tested for isoform-specific translation activity by using DART. Notably, 1,639 isoform pairs with reproducible differences in ribosome recruitment were identified (p<0.05, Bonferroni corrected two-tailed t test), of which 843 differed by more than 3-fold. These results provide significantly evidence that alternative 5′ UTRs differ in ribosome association in vivo. DART establishes the direct contribution of differences in 5′ UTR sequences to differences in translation initiation and eliminates potentially confounding effects of co-occurring alternative 3′-UTR sequences.

Example 1-5. C-Rich Sequences Silence Translation

These mRNA isoforms were leveraged comparisons to identify previously undetected translational control elements within 5′ UTRs. Enhancer and silencer elements were operationally defined as sequences present in a longer 5′ UTR variant that showed a higher RRS than a shorter alternative 5′ UTR of the same gene (enhancer) or lower RRS than the corresponding shorter alternative 5′ UTR (silencer). 658 enhancer regions and 541 silencer regions were identified by the criteria that their inclusion reproducibly changed RRS more than 2-fold (p<0.001, n=3 replicates). Of these, 72 enhancers and 67 silencers changed RRS by more than 10-fold (FIG. 4C). Remarkably, sequence differences of only ten nucleotides were sufficient to significantly alter translation initiation in many cases. Thus, DART reveals relatively short RNA sequences (10-13 nucleotides) that are sufficient to significantly alter ribosome recruitment when present near the 5′ end of the mRNA. Overall, it was found that 68% of genes with alternative 5′ UTRs showed significant differences in translation initiation between isoforms.

To illuminate the mechanisms of translational control, the first study looked for overrepresented motifs within enhancers and silencers using DREME (Bailey et al., 2015). Long 5′ UTR isoforms with higher ribosome recruitment activity were enriched for AU-rich sequences, which are distinct from the previously identified eIF4G-binding U7 motif. Intriguingly, the silencer regions were enriched in CCH motifs. The first study observed similar C-rich motifs in the bottom 10% of all 5′ UTRs (FIG. 4D), which suggests a common mechanism of translational repression.

The first study verified the repressive effects of C-rich silencer motifs on the translational output of full-length mRNAs by using luciferase reporters. For selected genes containing the motif of interest in the longer 5′ UTR isoform, mutations were introduced to disrupt the putative silencer in the long isoform, thereby testing its necessity for translation repression. In parallel, the motif was added to the short isoform, thereby testing its sufficiency. In each case, disruption of the motif from the longer isoform resulted in an increase in protein production whereas addition of the motif reduced luciferase activity from the short isoform (FIG. 4E). Similar effects with these constructs expressed in vivo were observed (FIG. 4E), and somewhat smaller differences in translation between 5′ UTRs in vivo and in vitro were noted. Together, these results validate the C-rich sequence motifs uncovered by DART analysis as translational control elements that repress ribosome recruitment in vitro and protein production in cells.

Example 1-6

Here DART is presented as a new approach for high-throughput functional testing of endogenous and engineered 5′ UTR variants. The first study applied DART to more than 8,000 endogenous 5′ UTRs from the model eukaryote S. cerevisiae and identified C-rich motifs as translational silencers present within hundreds of 5′ UTRs. The study also used DART to systematically probe the effect of oligo(U) motifs and thereby established a general stimulatory role for this 5′ UTR element in endogenous mRNAs. The results illustrate the power of the DART method to uncover the regulatory elements underlying mRNA-specific differences in protein output, which are anticipated will be broadly applicable to the study of translation initiation, including by human mRNAs.

′ UTR sequences that increased or decreased ribosome recruitment by more than 1,000-fold in cell lysates were identified. Specific sequences, such as C-rich motifs, that affected ribosome recruitment as measured by DART similarly affected protein synthesis from luciferase reporters in cells (e.g., FIGS. 4D and 4E). However, the magnitude of 5′ UTR differences was larger in vitro.

Example 1-7: Materials and Methods

The yeast strain YWG1245 (MATa trplDleu2-3,112 ura3-52 gcn2D::hisG PGAL1-myc-UBR1::TRP1::ubr1, pRS316 <URA3>) used in this assay was cultured in liquid YPAD (1% yeast extract, 2% peptone, 2% glucose, 0.01% adenine hemisulfate) at 30° C. with constant shaking.

5′ UTR Pool Design and Synthesis

Each sequence in the pool consisted of approximately 122 nucleotides of 5′ UTR sequence followed by at least 24 nucleotides of coding sequence followed by a randomized 10 nucleotide unique identifier barcode and an adaptor sequence used for priming reverse transcription and Illumina sequencing (FIG. 1A). For 5′ UTR annotations, 5′ UTR abundances were calculated from deep RNA sequencing of wild type yeast (Pelechano et al., 2013, 2014). Each 5′ UTR was merged with its most abundant neighbor within 10 nts in either direction such that no two 5′ UTRs were within 10 nts of each other. We then imposed the following requirements for inclusion in the pool: (1) 5′ UTRs must be expressed within 25% of the mode abundance for a given 5′ UTR, and (2) 5′ UTRs must make up at least 5% of the total abundance for that ORF, unless the mode was <5% of the total, in which case we used the mode. Upstream AUGs within 761 (6.3% of all) 5′ UTR sequences were mutated to AGT such that the first AUG encountered by a scanning pre-initiation complex moving 50 to 30 would be the annotated AUGi. We included a parallel set of constructs testing the ribosome recruitment activity of each uAUG individually, in which case the downstream (canonical) AUG was mutated to AGT. In total, the study measured recruitment to 1334 uAUGs. Designed oligos were purchased as a pool (Twist Bioscience) and PCR amplified with RN7 and RN8. RNAs were produced by runoff T7 transcription from gel-purified DNA template. RNAs were 5′ capped using the Vaccinia Capping System (NEB M2080S) and 3′ biotinylated using the Pierce RNA 3′ end biotinylation kit (Thermo Scientific 20160).

Translation Assays

Yeast translation extracts were made as described (Rojas-Duran and Gilbert, 2012) from YWG1245 (MATa trp1Dleu2-3,112 ura3-52 gcn2D::hisG PGAL1-myc-UBR1::TRP1::ubr1, pRS316 <URA3>) cultured in liquid YPAD (1% yeast extract, 2% peptone, 2% glucose, 0.01% adenine hemisulfate). Cultures were grown to mid-log phase, harvested and then washed two times in mannitol buffer (30 mM HEPES pH 7.4, 100 mM KOAc, 2 mM Mg(OAc)₂, 2 mM DTT, 0.1 mM PMSF, 8.5% mannitol). Cells were then resuspended in 1.5× volume of mannitol buffer and subsequently lysed by bead beating with 5× pellet volume of glass beads. Six 1 min rounds of bead beating were performed with intermittent one minute cooling periods on ice. Beads were pelleted and the supernatant transferred to a fresh tube. Cell debris was pelleted by a 30 min spin at 16,000 rcf Supernatant was removed and dialyzed using Slide-A-lyzer, 3-12 mL, 3,500 MWCO (Pierce #66110) for four h (30 mM HEPES pH 7.4, 100 mM KOAc, 2 mM Mg(OAc)₂, 2 mM DTT), changing the buffer once. Approximately 40 pmoles of mRNA were added per 2 mL in vitro translation reaction (22 mM HEPES pH 7.4, 120 mM KOGln, 3 mM MgOGln, 3.75 mM ATP, 0.5 mM GTP, 25 mM creatine phosphate, 1.6 mM DTT, 400U RNaseIn, 2 mM PMSF, 650 mg creatine phosphokinase, 1× cOmplete EDTA-free protease inhibitor) containing 50% yeast extract. Reactions were incubated with 0.5 mg/mL cycloheximide at 26° C. for 30 min in a shaking thermomixer.

To measure translation activity in vivo YWG1245 was transformed with pGAL-5′ UTR-Fluc plasmids and grown to log phase in media containing 2% raffinose. 5′ UTR sequences were generated by gBlock (Twist Bioscience) mRNA expression was induced by addition of galactose to a final concentration of 2%. Whole-cell lysates were prepared by vortexing with glass beads in 1×PBS with protease inhibitors (2 mM phenylmethanesulfonyl fluoride, and 1 3protease inhibitor cocktail (Roche). Luciferase activity was measured using the Luciferase Bright-Glo Assay System (Promega) on a Berthold Centro XS Luminometer. Luciferase values were normalized to both FLUC mRNA levels and total protein. Fluc mRNA levels were determined by Northern blot on total cellular RNA isolated from whole-cell lysates by hot phenol extraction and normalized to U1 RNA levels. Fluc mRNA levels were determined by Northern blot on total cellular RNA isolated from whole-cell lysates by hot phenol extraction and normalized to U1 RNA levels. Probes made using radiolabeled PCR products from the following primer pairs: 5′-AAGGCGTGTTTGCTGACGTTTC-3′ (SEQ ID NO: 52), 5′-CACCCGTTCCTACCAAGACC-30 (U1) (SEQ ID NO: 53); 5′-TGGGCGCGTTATTTATCGGAGTTGC-3′ (SEQ ID NO: 54), 5′-GAGCCCATATCCTTGCCTGATACC-3′ (Fluc) (SEQ ID NO: 55).

80S Isolation

Translation reactions were loaded onto 10%-50% sucrose gradients in polysome lysis buffer (20 mM HEPES-KOH pH 7.4, 2 mM magnesium acetate, 0.1 M potassium acetate, 0.1 mg/mL cycloheximide, 1% Triton X-100) and centrifuged at 27,000×g in a Beckman SW28 rotor for 3 h. Gradients were fractionated from the top down using a Biocomp Gradient Station (Biocomp Instruments) with continual monitoring of absorbance at 254 nm. Fractions corresponding to the 80S peak were pooled and RNA extracted using phenol/chloroform followed by isopropanol precipitation.

Library Preparation

RNA pellets from the input pool, total lysate, and gradient fractions were resuspended in binding buffer (0.5M NaCl, 20 mM Tris-HCl pH 7.5, 1 mM EDTA) and biotinylated 5′ UTRs were recovered using Hydrophilic Streptavidin Beads (NEB S1421S). Isolated RNA was reverse transcribed using the barcoded primer OWG921 and Superscript III (Invitrogen 18080093). Gel-purified cDNA products were ligated to the adaptor OWG920 using T4 RNA ligase 1 (NEB M0437M). cDNA cleanup was performed using 10 ml MyOne Silane beads (Thermo Scientific 37002D) per sample. Libraries were then PCR amplified with primers RP1 and OBC and sequenced on a HiSeq 2500.

Example 2: Identification of Additional Yeast Translational Enhancers and Translational Silencers

In the second study described herein (“the second study”), using the method developed in the first study, translational enhancers and translational silencers in the 5′ UTR were determined in the budding yeast. These enhancers and silencers are shown in FIGS. 7 and 8 and listed in Table 1 below:

TABLE 1
Identified Saccharomyces cerevisiae translational
enhancers and translational silencers
Translational Enhancers UUKKA (SEQ ID NO: 1)
                        RUURA (SEQ ID NO: 2)
                        WUAG (SEQ ID NO: 3)
Translational Silencers CCC (SEQ ID NO: 4)
                        UCCWH (SEQ ID NO: 5)
                        WCC (SEQ ID NO: 6)

Example 3: Identification of Additional Human Translational Enhancers and Translational Silencers

In the third study described herein (“the third study”), using the method developed in the first study, translational enhancers and translational silencers in the 5′ UTR were determined in humans.

Specifically, a human 5′ UTR pool was designed and synthesized. In this 5′-UTR pool, each sequence in the human 5′ UTR pool consisted of a T7 promoter followed by between 10-230 nucleotides of 5′ UTR sequence followed by at least 24 nucleotides of GFP coding sequence followed by an adaptor sequence used for priming reverse transcription and Illumina sequencing. 5′ UTR sequences were derived from Ensembl annotations. Designed oligos were purchased as pools (Twist Bioscience) and PCR amplified. RNAs were produced by runoff T7 transcription from gel-purified DNA template. RNAs were 5′ capped using the Vaccinia Capping System (NEB M2080S).

In the human translation assays, 20 pmoles of pool RNA were added per 500 microliter translation reaction (16 mM HEPES KOH pH 7.4, 40 mM KOGln, 2 mM MGOGln, 0.8 mM ATP, 0.1 mM GTP, 20 mM creatine phosphate, 0.1 mM spermidine, 1.6 mM DTT, 2 mM PMSF, 140U RNasin Plus, 165 mg creatine phosphokinase, 1× cOmplete EDTA-free protease inhibitor) containing 50% Hela cytoplasmic extract (Ipracell). Reactions were incubated with 0.5 mg/mL cycloheximide at 37° C. for 30 min in a shaking thermomixer.

The human 80S was isolated according to the following: translation reactions were loaded onto 10%-50% sucrose gradients in polysome lysis buffer (20 mM HEPES-KOH pH 7.4, 2 mM magnesium glutamate, 0.1 M potassium glutamate, 0.5 mg/mL cycloheximide, 10% Triton X-100) and centrifuged at 35,000×g in a Beckman SW41 rotor for 3 h. Gradients were fractionated from the top down using a Biocomp Gradient Station (Biocomp Instruments) with continual monitoring of absorbance at 254 nm. Fractions corresponding to the 80S peak were pooled and RNA extracted using phenol/chloroform followed by isopropanol precipitation.

The study confirmed that the DART analysis developed in the first study is highly reproduceable (FIGS. 9A-9B).

One batch of identified enhancers and silencers are shown in FIGS. 11A-11B, and listed in Table 2 below:

TABLE 2
Identified human translational enhancers
and translational silencers
Translational Enhancers DUUUB (SEQ ID NO: 7)
                        AADAW (SEQ ID NO: 8)
                        UUSWD (SEQ ID NO: 9)
                        UAYW (SEQ ID NO: 10)
                        WKWA (SEQ ID NO: 11)
                        WGGWA (SEQ ID NO: 12)
                        AWW (SEQ ID NO: 13)
                        CAACUGCW (SEQ ID NO: 14)
                        USUU (SEQ ID NO: 15)
                        CUUMCCAU (SEQ ID NO: 16)
                        AAGACCCM (SEQ ID NO: 17)
                        GAGACGAA (SEQ ID NO: 18)
Translational Silencers CNCCCV (SEQ ID NO: 19)
                        CBCCDC (SEQ ID NO: 20)
                        CCBYC (SEQ ID NO: 21)
                        HCCCR (SEQ ID NO: 22)
                        CCC (SEQ ID NO: 23)
                        CWCC (SEQ ID NO: 24)
                        CKCGC (SEQ ID NO: 25)
                        GCC (SEQ ID NO: 26)
                        YGUCC (SEQ ID NO: 27)
                        CGR (SEQ ID NO: 28)

The study further shows that the incorporation of modified nucleobases, such as the NJ-methylpseudouridine, in the 5′ UTRs resulted in in the change of translational efficiencies (FIGS. 10A-10B). The most efficiency human 5′ UTR sequences with N1-methylpseudouridine identified in this batch are listed below in Table 3:

TABLE 3
	log2RRS
Identifier	(m1Psi)	Sequence
ENSG00000187514-	4.778818414	CCCCCACUGGCUGCUCUGAAAAGCCAUCUUUGCAUUG
ENST00000409115-		UUCCUCAUCCGCCUCCUUGCUCGCCGCAGCCGCCUCCG
182		CCGCGCGCCUCCUCCGCCGCCGCGGACUCCGGCAGCUU
		UAUCGCCAGAGUCCCUGAACUCUCGCUUUCUUUUUAA
		UCCCCUGCAUCGGAUCACCGGCGUGCCCCACC
		(SEQ ID NO: 29)
ENSG00000206069-	2.68842281071736	AUUGUUCUACAAGCUAAAUUAUUCCUUCAAAGGAG
ENST00000640159-		AGGAGAAUUGUAUAAGGUCACAGACGUGGAUCCAA
140		AGCCGGAGCCUGAGCAGAGGUGGCCACGCUGGAGG
		GUCUUGACCUAAAGUGUGGUCAGCGAUACUGCCUA
		(SEQ ID NO: 30)
ENSG00000184515-	2.616826934	AGUUGCAGUCUGGUAGUUGUCGCUGGCCGUGUGACGG
ENST00000333643-		CUCGCUGUUGCCCUGAAGGCAGGCGAGCCAGCUGCCC
223		AGGAAAGGUGGAAAGUGGUAGAAGCUGACCCCUGAGC
		CCUGGCAGGUCUUUAAGUGCGUUUGUGCAGCCGAUUU
		CAAGGCUAAGAGAGAAAGACUGCCUCUGAUCCCUGAA
		GGAAGAAAAAAAAAAAAAAAACAGGAAAAAAACUCA
		AC (SEQ ID NO: 31)
ENSG00000154305-	2.187493918	GACGUGUUUUAUAGGCGGCAUAAAGCGAAAGUGCAGG
ENST00000340535-		CAGCUGUGGAAGGCGAAGUUCAAUCCCAGAGUCCGCC
173		CCCUGAAUUGGGGCCUUUCCGGAGGAGGAAGCUCUGA
		AAAACAGGGGGCCCAGUGCCAUUCCGCAGGGAAUUGU
		CGCUUGCGUUCAGCUGUUCUACACA
		(SEQ ID NO: 32)
ENSG00000145244-	1.947769934	AGUUCAGUUUGUCUCUCUUGAGCUUGGAGAAAAUCAU
ENST00000502252-		CCGUAGUGCCUCCCCGGGGGACACGUAGAGGAGAGAA
123		AAGCGACCAAGAUAAAAGUGGACAGAAGAAUAAGCGA
		GACUUUUUAUCC (SEQ ID NO: 33)
ENSG00000143799-	1.934885519	AGGCAUCAGCAAUCUAUCAGGGAACGGCGGUGGCCGG
ENST00000677091-		UGCGGCGUGUUCGGUGGCGGCUCUGGCCGCUCAGGCG
171		CCUGCGGCUGGGUGAGCGCACGCGAGGCGGCGAGGCG
		GCAGCGUGUUUCUAGGUCGUGGCGUCGGGCUUCCGGA
		GCUUUGGCGGCAGCUAGGGGAGG (SEQ ID NO: 34)
ENSG00000155380-	1.872300924	AAAACAGAAACCAUAAGGCCUACCUCCCAGGGUUGCU
ENST00000679803-		GUGAGAAUUGAGGGGGAGGAUAUUUGGAUUUGACCU
100		GCAUUUUGGAAUUUAUCUACACUUAAA
		(SEQ ID NO: 35)
ENSG00000115159-	1.85654596	AUUAGUACAGCACCCAGAGGUCUUCGGAGCAAAGCUG
ENST00000415049-		UUAAAGAAGUGGGGUCCAUUUGAGCCCCAACUUUGCC
128		UUCCUUAGGUCCCCUUGGGCUUGUCUAGCCCUAGGAG
		UUCCAACAAGCUAAGAA (SEQ ID NO: 36)
ENSG00000124374-	1.844203412	AGUGUGCAGUAAGAGAUAACCUGGCAAGUGGUAGUGG
ENST00000244221-		CGCUUCUCGGGUGCUGUGCUUCACGUUUUGGUACUAA
187		AGGCCGAGACUGUUGUGGCGACGGCGACCUCUACGGC
		AACGGCUUAAGCUCUCGGAGGAGUGGCAGAGUACGAU
		CUGAAGGAGGGGCUUCUGGUUAGCCCAGGUUCCAUCA
		UA (SEQ ID NO: 37)
ENSG00000154760-	1.798983187	GGAAACGCGGAGUGUCCUGGAGCUUGACGCGCUGGAG
ENST00000285013-		CUUGAGAGGUCUUUCAGGACUGAUUUUGGUGGAAGAA
205		GACAGCAGGCGGUGGGCAUUCACUGUGCUGGUGGGAA
		GUCUGGUUACAUUAAGAAAGGAAUUCUAGCAAAGUUA
		UUCUGUAAAUACAACAGAAUCAGUUGCUUUUGUUAAA
		UAUAUUGGUGCAAGUUCAAC (SEQ ID NO: 38)
ENSG00000176102-	1.778455315	AAUUCAUAUUUGAGUGGGGGUGGCGAUUGGUGUUG
ENST00000323959-		GCGGUCUGGCUCAGCUGGGCAGGGGGUAACUUUACUG
155		AUUUGGGGGUGGUUUUUAGUUUAAUUUUUCUUUUCU
		AGCUUCCCAUCGACGGUCAGUGCGCACGUUGUAAUCA
		GCUGAGGCC (SEQ ID NO: 39)
ENSG00000175294-	1.769363289	AGUCUGCAUUGAGCUUGGCUCAGGAAAGAAGGGAAAU
ENST00000312106-		CCAGGCGGGGCCUGUUGGGCCCAGGUCUUGAGCUCUU
100Fluc		UUGGCUCCAGAGUUCCCAGCACAGUC
		(SEQ ID NO: 40)
ENSG00000170290-	1.743646862	AGACAGCCUGGGAGGGGAGAAGGAGUUGGAGCUCAAG
ENST00000305991-		UUGGAGACAGCGAGGAGAAACCUGCCAUAGCCAGGGU
169		GUGUCUUUGAUCCUCUUCAGGAGGUGAGGAGAAGCCA
		GAGGUCCUUGGUGUGCCCUCAGAAAUCUGCCUGCAGU
		UCUCACCAAGCCGCUGUGAAA (SEQ ID NO: 41)
ENSG00000138468-	1.740036667	UUUUUUUUUUUUUUUUUUUUUUUUUUUUCCUUUCCCC
ENST00000314261-		UCCCCCUCCCUCUCCAAGCCGGAGGGGUCCUGAGGUG
111		ACAGCGCCUGCAACUGAAAUUUCAGCAGCGGGAGAAG
		(SEQ ID NO: 42)
ENSG00000171657-	1.708240385	ACACUGACUAAAGAUAUUGGAAGAGUGAAGAUCAGAG
ENST00000302548-		AAUUUUAAGUCUGAAAUUUGGCAUCACUGCCCUGAAC
214		AAUAUAACCUUAGUUGGCAUAAACUACUCAUACAGAC
		AAAGGCAUUAUCCAUCACAAUAAGUAACUUUUUGUCU
		UUAUUUCAACCGGACAAUCGUGAUUAGAAAAGCUCCU
		GUGACAAAAUUCAAGAAAACCUGACAUAA
		(SEQ ID NO: 43)
ENSG00000154760-	1.687013216	AAACGCGGAGUGUCCUGGAGCUUGACGCGCUGGAGCU
ENST00000534689-		UGAGAGGUCUUUCAGGACUGAUUUUGGUGGAAGAAG
203		ACAGCAGGCGGUGGGCAUUCACUGUGCUGGUGGGAAG
		UCUGGUUACAUUAAGAAAGGAAUUCUAGCAAAGUUAU
		UCUGUAAAUACAACAGAAUCAGUUGCUUUUGUUAAAU
		AUAUUGGUGCAAGUUCAAC (SEQ ID NO: 44)
ENSG00000105357-	1.665273017	GAGGCUGCAGCAGCACAUACAGGAGCUAGAGGCCC
ENST00000262269-		ACCUUGAGGCUGAGGAGGGUGCGCGGCAGAAGCUG
100		CAGCUGGAGAAGGUGACGACAGAGGCAAAA (SEQ
		ID NO: 45)
ENSG00000164919-	1.661077612	AUUCUGCGCCUGCGCGCGGCUACAGCACGGUUCGUUU
ENST00000520468-		UUCCUUUAGUCAGGAAGGACGUUGGUGUUGAGGUUAG
100		CAUACGUAUCAAGGACAGUAACUACC
		(SEQ ID NO: 46)
ENSG00000163762-	1.65902399510468	GAGAGAGAGAGAGAAAAAAAAGGUCAGGUAGGAAGA
ENST00000470080-		AGAAAAAUAGACUUUCUGUGACUGUAUACUCUUGAAA
100		UCUCCCGCAGGUUCUAAGCAGGGCAAA
		(SEQ ID NO: 47)
ENSG00000061492-	1.636603322	CAGAAUUUUCUCACAUAAAUACUGAGGAAGACCCUGC
ENST0000a0361560-		CCUCUCCUCACUUCUCUGGACUUGGCCCUGAGCUGGA
100		CCUGGUCCACUGGGGUAGGCAGGGCG
		(SEQ ID NO: 48)
ENSG00000138311-	1.616348731	AGUCUGAUUUACGGCUCUGCUGAAAACCGCUUCGCUC
ENST00000395254-		CCGCAGCAUCAGCACCGGAGGCGGCGGCUGCAGCAGC
103		AGCAGCAACAAGUCGGGACUUUUAGAGUA
		(SEQ ID NO: 49)
ENSG00000117308-	1.612147772	AUUAGUCACUGCGCCCAGGAGCCAGUUUACACCUAGC
ENST00000445705-		GAAGGCGGAGGCAUUGGACAAGCCUGGGUCUGAGCAG
210		ACAGAACCCCUUCCUGCGACCCUGGAGUCCCAAUCGU
		GCUGCCAUUUUCCUUCUGCCCAGGACUCUCCAGUCCU
		CAGUCACCUUGGACAAAGAAGUGUGGAUCCUCAGAUU
		CCAUCUUUUCCAACUCCAAGGUGCC
		(SEQ ID NO: 50)
ENSG00000078369-	1.610202699	CUGGAAGGUCUGGGGGACUGAGGGAAGCGAAGAGAAA
ENST00000437146-		AGCAAGAGCAAUUAAAUAUCUCACAUUCUUGAAGGUG
100		GCAUUGAAGAGCACUAAGAUCGGAAG
		(SEQ ID NO: 51)

A further screening identified more than a thousand short 5′-UTR sequences that, when combined with N1-methylpseudouridine, resulted in higher translational efficiency than the 5′-UTR used in Moderna mRNA-based vaccine. The short 5′-UTR sequences in this batch are listed below in Table 4 below:

TABLE 4
	m1Psi_	SEQ
	AVG_log2	ID
ID	RRS	NO:	Sequence
ENSG000	1.169790902	SEQ	CUGCUUGGCUUUGAGGAAGAGUGGCAGUACUGCCU
00000457-		ID	CACUGCAUAAGGG
ENST000		NO:
00367770-		56
48
ENSG000	1.254321398	SEQ	GAAGCUCUCCUGUUUGACGAAAGU
00000460-		ID
ENST000		NO:
00459772-		57
24
ENSG000	1.42504224	SEQ	AUAGCCUAGAUCGAGCUCCCUGUGUGCACCGCGCGC
00002016-		ID	UGCCCGAGAGGUCAACCAGAAUCAAG
ENST000		NO:
00544742-		58
62
ENSG000	1.641692433	SEQ	UAGAAGAGUGAUAUUUGUGUGAGAGCCUGGGUCAG
00003096-		ID	GCUUAUUUUGAGACGUGGGCCCCACUGAGGUCAUU
ENST000		NO:	AUCCAACUUUUAGAGGUG
00541812-		59
88
ENSG000	1.198841244	SEQ	AGGACUGAGUUCUGAAUUAACUAAAGUAACUUGUC
00003402-		ID	UGGUUUGCAGAGUGCUG
ENST000		NO:
00479953-		60
52
ENSG000	1.386556667	SEQ	UCAGAAACUGUUAGUUGGCAAAGGAGUUACCAUCU
00003402-		ID	CCUAUUAAACGGGCAAGGACAAGUUCCCUUUUCUG
ENST000		NO:	AGAGUGCUG
00494258-		61
79
ENSG000	1.108285028	SEQ	ACUUCGGCGGAC
00004455-		ID
ENST000		NO:
00548033-		62
12
ENSG000	1.39092934	SEQ	ACUAGUGCUUCCUAGUGUCAGGGCCAGCUGUGUAG
00004766-		ID	UGGCUCGGUGUGAUUUGUUAGCUCUUUGAGGCAGG
ENST000		NO:	GUACCCUCCUCAGGAUUUCGAU
00436177-		63
92
ENSG000	1.351422107	SEQ	ACAACAAAGCUUCCAGAGGGAGAGGAAGG
00005981-		ID
ENST000		NO:
00325885-		64
29
ENSG000	1.473564565	SEQ	UGGGAAAUAAAGUCAUUUGUAGUUUUUUCUCUCUU
00006576-		ID	GCACAGCCUAAAAGUACCAAGUUGUGAUUUCAGUG
ENST000		NO:	GAAUAA
00248550-		65
76
ENSG000	1.538217907	SEQ	ACAGAAGACUGGACACAAUUCCGAAGAGCUGCCCA
00006659-		ID	GAAGGAGAGAACA
ENST000		NO:
00392052-		66
48
ENSG000	1.117959259	SEQ	UGCUGCUCUCGGUUUAGUCCAAGAUCAGCGAUAUC
00006747-		ID	ACGCGUCCCCCGGAGCAUCGCGUGCAGGAGCC
ENST000		NO:
00297029-		67
67
ENSG000	1.244066478	SEQ	GCUGCUCUCGGUUUAGUCCAAGAUCAGCGAUAUCA
00006747-		ID	CGCGUCCCCCGGAGCAUCGCGUGCAGGAGCC
ENST000		NO:
00436854-		68
66
ENSG000	1.154217639	SEQ	AGCUCCUGGCGCCUGCGAUAGCGGCAAG
00007341-		ID
ENST000		NO:
00358039-		69
28
ENSG000	1.193659185	SEQ	CUGCCUUGCUCUGCCAGGAACC
00007384-		ID
ENST000		NO:
00417043-		70
22
ENSG000	1.105464088	SEQ	GUGAAAGGUUGCGAAG
00007923-		ID
ENST000		NO:
00377577-		71
16
ENSG000	1.108125958	SEQ	AAGAAGCGGAGAUUUAACGGGGACGUGCGGCCAGA
00010704-		ID	GCUGGGGAA
ENST000		NO:
00336625-		72
44
ENSG000	1.66013041	SEQ	UCUCUUACUUCAAAGACUGAACAUUCUUCACGAUC
00011258-		ID	UGAAAGGAAAAGAAGAGAUUCUUUCGGG
ENST000		NO:
00415868-		73
63
ENSG000	1.1337154	SEQ	UCGGGCAUUAAAAAAUAUUUAAUCAUUCAGUUGUU
00011454-		ID	GAGACUCAUUCUUGAGUU
ENST000		NO:
00426918-		74
53
ENSG000	1.502675649	SEQ	AUUCUACAGUGCAAGUAGCUUUGAUUGUCAGGGUU
00011465-		ID	CAGGUUCCCUGGUUGUGAAAAUACAGUAGAUAAAU
ENST000		NO:	C
00550563-		75
71
ENSG000	1.182322223	SEQ	GUUGCUUGGGCGCUUCUCCGCUGCGUGUAGGUGAA
00013375-		ID	GGGGGCUUCCUGACCGAGAC
ENST000		NO:
00512866-		76
55
ENSG000	1.353206743	SEQ	UACAGUUUGAAGACAGUAAUACCUGGAAUUGAGCA
00013441-		ID	UCAGUUCUGUCAUUCUUAAAUUUGC
ENST000		NO:
00409769-		77
60
ENSG000	1.222017984	SEQ	AAUCCCUUAAUUAAAUAGCUUCCCCUCUACAGGCUU
00014257		ID	UUGAAGUGGUAGCAGUUCCUCCUAACUCCUGCCAG
ENST000		NO:	AAACAGCUCUCCUCAAC
00495911-		78
88
ENSG000	1.393481764	SEQ	AGACCACAGAGCCCUGGGUUGUGGAAGAGGUGGCU
00014919-		ID	GUUCCCUGUCAUCAGU
ENST000		NO:
00370483-		79
51
ENSG000	1.447526496	SEQ	GUUUAAAAUUAUCCAACUGCCAUAGAGCUAAAUUC
00018236-		ID	UUUUUUGGAAAAUUGAACCGAACUUCUACUGAAUA
ENST000		NO:	CAAG
00348761-		80
74
ENSG000	1.650397087	SEQ	GAAAGUUAGUUGCUUUCUUAACCUCAUCAAAUUCA
00021826-		ID	GUAAGAUUUAGCCGAGGCCCAGUCCACAAAUCAUC
ENST000		NO:	AAA
00673711-		81
73
ENSG000	1.309628047	SEQ	GUUAAGCUAGUCCAGAGCCGAGUCCAAAUUUUAUU
00022267-		ID	CCGGUACAGGG
ENST000		NO:
00539015-		82
46
ENSG000	1.148156641	SEQ	AGAAUUCAGAACUUUGCUUCUAAAAAGGUCCCUCC
00022267-		ID	AGCUACAAGGUGGGCACC
ENST000		NO:
00628032-		83
53
ENSG000	1.321011671	SEQ	AGAGUUAGCCGAGGCCGCCAUAUUGAAUAAGCGAC
00023228-		ID	CCGGCCUCCUAGGGGGUCGUCGUGGUCCAGACAGUU
ENST000		NO:	UAGCAGAACAGCCUCCGCGGCUCCGGGGAGAAGCAA
00233190-		84	U
108
ENSG000	1.406012596	SEQ	AUAUUGAAUAAGCGACCCGGCCUCCUAGGGGGUCG
00023228-		ID	UCGUGGUCCAGACAGUUUAGCAGAACAGCCUCCGCG
ENST000		NO:	GCUCCGGGGAGAAGCAAU
00440274-		85
89
ENSG000	1.459698608	SEQ	UAUUAAUAGAAGAGUCUUCGUUCCAGACGCAGUCC
00023839-		ID	AGGAAUC
ENST000		NO:
00649493-		86
42
ENSG000	1.23653664	SEQ	CUUCAUUUCCCAUCGUGCUGAGGCGGGUGGCAGUG
00028203-		ID	CGGAGAAGG
ENST000		NO:
00436874-		87
44
ENSG000	1.452349547	SEQ	GCAGAUCAGCGGAAGUGCUAAAGUAAGGUGCUAUA
00031081-		ID	CUUUACUUAAAAGGUGAAA
ENST000		NO:
00482743-		88
54
ENSG000	1.222568403	SEQ	AACAGUUGCCUUUUCCUCUCACAGAAGGAAGAUUU
00035720-		ID	CAUUUUGUUUGAGACGAGAAACCAAACCACACACC
ENST000		NO:	AAAGAGAGGGGU
00396225-		89
82
ENSG000	1.785440513	SEQ	ACGUGGACGUCAACAGCA
00036054-		ID
ENST000		NO:
00344949-		90
18
ENSG000	1.223366542	SEQ	AAUUGUAAAGAGAGAGAAGUGGAUAAAUCAGUGCU
00038945-		ID	GCUUUCUUUAGGACGAAAGAAGU
ENST000		NO:
00262101-		91
58
ENSG000	1.219486289	SEQ	UAGGUUUCAAUUGUAAAGAGAGAGAAGUGGAUAAA
00038945-		ID	UCAGUGCUGCUUUCUUUAGGACGAAAGAAGU
ENST000		NO:
00381998-		92
66
ENSG000	1.334322058	SEQ	AGAUUUGCUCUCACUGCUCCCAAAA
00039123-		ID
ENST000		NO:
00230640-		93
25
ENSG000	1.24977856	SEQ	AGUUUUGAGCAUACUUCUGAACUGGCUUUUGUUGA
00048740-		ID	GACUAUCAGUAUAGAAGC
ENST000		NO:
00633200-		94
53
ENSG000	1.183441512	SEQ	GAGACAGUUGAAAGUUCUCUACAACAGAAGCCAAG
00049247-		ID	AAGGAAGCCGUCUAUCUUGUGGCGAUC
ENST000		NO:
00361696-		95
62
ENSG000	1.305957441	SEQ	UUUCUCCCCGAG
00049540-		ID
ENST000		NO:
00428787-		96
12
ENSG000	1.606022945	SEQ	GAGAAUAAAAACAGUGCUUUUGAGUAAAAAGUCAU
00050730-		ID	UUAACAGAUUCCAGUUGGAGUGCUC
ENST000		NO:
00507879-		97
60
ENSG000	1.135865322	SEQ	AUAUUGCAGGACGCUGCAUC
00050748-		ID
ENST000		NO:
00397072-		98
20
ENSG000	1.147992378	SEQ	AGUCAAUUAGUUAAAGACUCUGACAUCUGCUAGGC
00053702-		ID	GGGAGGCAAGAGACCUAACAAGCAGGGGCC
ENST000		NO:
00542990-		99
65
ENSG000	1.126727287	SEQ	UUCACUUCUUCAACUGAGAGUGACAGUAUAUAAUC
00054654		ID	UCCAUUGAGUCAAAGA
ENST000		NO:
00554584-		100
51
ENSG000	1.194826351	SEQ	AGACACACAUAGCCUCUCUGCCCACCUCUGCUUCCU
00057149-		ID	CUAGGAACACAGGAGUUCCAGAUCACAUCGAGUUC
ENST000		NO:	ACC
00283752-		101
74
ENSG000	1.289797178	SEQ	GUCAGUCCCAGUGGGAAGUUCAACAGGCAGGGGCA
00057593-		ID	GCACUGCAGAGAUUUCAUC
ENST000		NO:
00541084-		102
54
ENSG000	1.251738427	SEQ	ACGCUUUGCGGCUGUCGUCGGAGAGGCAUCUGGGU
00058729-		ID	UCGGACUGGGGCCGCC
ENST000		NO:
00510384-		103
51
ENSG000	1.098136979	SEQ	GUCCUCGCAGCC
00061794-		ID
ENST000		NO:
00081029-		104
12
ENSG000	1.438331965	SEQ	ACCUGGCCGAGCAGGAGGCGCCAUC
00063177-		ID
ENST000		NO:
00547897-		105
25
ENSG000	1.361048302	SEQ	CAAAGCUGGCUCUGCAGGGGAC
00064205-		ID
ENST000		NO:
00190983-		106
22
ENSG000	1.1348426	SEQ	CUGCUCUGUUAAAAGCGAAA
00064933-		ID
ENST000		NO:
00424307-		107
20
ENSG000	1.097381246	SEQ	CCCUCCGGGAAG
00065427-		ID
ENST000		NO
00562875-		108
12
ENSG000	1.287728744	SEQ	AGAGAGAGGGGGAUUUAUUCAAAGUUGUUUCCAAU
00065618-		ID	UCCUUCAAAACCUCAAACCAGGUGGCUAGUGU
ENST000		NO:
00393211-		109
67
ENSG000	1.147916239	SEQ	UUGGCUCCAGACAAAUAAAC
00066427-		ID
ENST000		NO:
00557030-		110
20
ENSG000	1.336270833	SEQ	CGAUAGACGAGGACGCCAACAGCAGCGGAGAAACG
00066654-		ID	UUUCUCUUUCCUCUCAGUUUGCGCACACC
ENST000		NO:
00565248-		111
64
ENSG000	1.295319418	SEQ	GAGAAAGCUGUCUAGGUAGAGUUCAGUCAGCCCAG
00067225-		ID	UGACCUCAGCAGCC
ENST000		NO:
00564178-		112
49
ENSG000	1.256881067	SEQ	UGACAAGACCACAAUCUGAUCCCAAAG
00068781-		ID
ENST000		NO:
00394751-		113
27
ENSG000	1.261796623	SEQ	GAUUGUCUGUGCUCUGAGCAGGCUGAAGUGACUGG
00069702-		ID	ACGAGACGCACUGUUGGAGAAAUAAAA
ENST000		NO:
00525962-		114
62
ENSG000	1.816127806	SEQ	AUUUUCUUCAAUCACAUCUGAAUAAAUCACUUGAA
00070669-		ID	GAAAGCUUAUAGCUUCAUUGCACC
ENST000		NO:
00454046-		115
59
ENSG000	1.137119928	SEQ	AGUUGAAAACUUACAGAGUCCUGAGGCUUUCAGAC
00070718-		ID	UGAAAAAGGCUUUCUUCUGUCACUGACAAUCGCCA
ENST000		NO:	CC
00517922-		116
72
ENSG000	1.77062527	SEQ	CGCUGAGAGCAGCAAGGCCAGAGUUGAAAACUUAC
00070718-		ID	AGAGUCCUGAGGCUUUCAGACUGAAAAAGGCUUUC
ENST000		NO:	UUCUGUCACUGACAAUCGCCACC
00530375-		117
93
ENSG000	1.319758271	SEQ	UCAUCGUUUUGAAGAGUUCUGCGUUUUGCCAGUCA
00071051-		ID	CCUCUCAACUGUGUGCCAAAGGACUCCAGUAAAG
ENST000		NO:
00522586-		118
69
ENSG000	1.829424723	SEQ	CACAGAGCGACAGAGACAUUUAUUGUUAUUUGUUU
00071054-		ID	UUUGGUGGCAAAAAGGGAAA
ENST000		NO:
00413150-		119
55
ENSG000	1.170950597	SEQ	AGCCGCACUCGCCAGCGACUCAUCUCUCCAGCGGGU
00071575-		ID	UUUUUUUUGUUUGUCGUGUGCGAUCCUCACACUC
ENST000		NO:
00405331-		120
70
ENSG000	1.118018921	SEQ	AGUGUUUGAUAAAGACAGCUCCUCUUAGGAAGAAC
00072080-		ID	UGUCAUCCCCAAACACAUAGAGAGACACUCUCUGUC
ENST000		NO:	UCUCGAUUACAAUC
00168148-		121
85
ENSG000	1.451902319	SEQ	AAUCCGCAUUCAGUUGUCGAGGAGUGCCAGUCACC
00072571-		ID	UUCAGUUUCUGGAGCUGGCCGUCAAC
ENST000		NO:
00393915-		122
61
ENSG000	1.447852479	SEQ	CUUUUCGCGCGAAACCUGGUUGUUGCUGUAGUGGC
00073111-		ID	GGAGAGGAUCGUGGUACUGCU
ENST000		NO:
00265056-		123
56
ENSG000	1.358968597	SEQ	ACUUUUCGCGCGAAACCUGGUUGUUGCUGUAGUGG
00073111-		ID	CGGAGAGGAUCGUGGUACUGCU
ENST000		NO:
00474964-		124
57
ENSG000	1.410113142	SEQ	AAAGGGAAGCGAAGCCGGAGCUGCGGGCGCUUUUU
00073584-		ID	CUGCCCGCGGUGUCUCAGAUUCAUUCUUAAGGAAC
ENST000		NO:	UGAGAACUUAAUCUUCCAAA
00580419-		125
90
ENSG000	1.460575417	SEQ	AGAAAGUUUAAAGUGCUGAGUGAUUUGCACUAGCU
00073969-		ID	GUAUAGAUCUUUGGUGGAGGAGGAAAGUGGAAAAU
ENST000		NO:	UAUUAAUUUCAGAGC
00571172		126
85-
ENSG000	1.115293315	SEQ	ACCGAGCUGCCUGCC
00074660-		ID
ENST000		NO:
00573852-		127
15
ENSG000	1.113548171	SEQ	CCGAUACUCAGCCCUCUGCGACC
00075239-		ID
ENST000		NO:
00531813-		128
23
ENSG000	1.192169419	SEQ	UAGAGUUGAAGAACAGACUCAAACCAGGUUUUUAU
00075303-		ID	UUAAUUAGUUAAAAAU
ENST000		NO:
00429674-		129
51
ENSG000	1.146633395	SEQ	AGCAGACACUGGAAGUUGAAGUCAUUGGGAGGUGA
00075420-		ID	GCCCUUAAGGAGAGCCCAA
ENST000		NO:
00443501-		130
54
ENSG000	1.316791348	SEQ	UAUUUUUAUUUACAGUUUUUGUUCAACUAGGCAAC
00075711-		ID	UUAAAAUAGUUUUGCUUUAGUUAUAAAAUAUUGUA
ENST000		NO:	AGUGUAGAGUA
00658155-		131
81
ENSG000	1.304083668	SEQ	UCUCUCUCGCUCGUUCCCUAACAUUAAAGAGAAA
00076067-		ID
ENST000		NO:
00552916-		132
34
ENSG000	1.094285381	SEQ	CUAGACGUUUCCUUGGCUCUUCUGGCGCCAAA
00076242-		ID
ENST000		NO:
00457004-		133
32
ENSG000	1.247415306	SEQ	UCUAGACGUUUCCUUGGCUCUUCUGGCGCCAAA
00076242-		ID
ENST000		NO:
00673972-		134
33
ENSG000	1.264737114	SEQ	AGAGACACGAAUAGUUUUCAGCCGCAACAGGCUGC
00077044-		ID	GUUUCAGCCGGAAGAGUGAAAGGGCACCUUGAAAA
ENST000		NO:	CGCAAGUUU
00409813-		135
79
ENSG000	1.360777028	SEQ	AGAUCGUAAACAAAACCCAGGACGCCAGGCAGAUU
00077063-		ID	UCUGUGUUAACAAGAAAAAAGAGUUUGAGUUGGAU
ENST000		NO:	ACUCUCAGUAAAUCCGAGCUGCGG
00434890-		136
94
ENSG000	1.123328923	SEQ	CGCUUUUUCCGCGGGCGCUUGAUAACGCGGGUGAG
00077935-		ID	GCGUGGAGGGCGGCGCC
ENST000		NO:
00404354-		137
52
ENSG000	1.381292769	SEQ	UUAUAUUUAAGCAGUGAGAGUAUUUACGUCAAGAU
00078142-		ID	CAACUUAUUCUUCAAAUCAUUUCACUC
ENST000		NO:
00589056-		138
62
ENSG000	1.118461149	SEQ	CUGGUUUCUUGCCUUAAGGAGCCCAUUGCCUUUCCC
00078304-		ID	GCUGAAGUCUAG
ENST000		NO:
00334743-		139
48
ENSG000	1.718228618	SEQ	AGCAGUUUCUGAGCUGCAAAAACUAGUUUCUAAAC
00078674-		ID	AGAGAGUUAAUUGUUAAAUCCAGU
ENST000		NO:
00524226-		140
59
ENSG000	1.167182176	SEQ	ACUUUCUUUUGUAAAGUUGGUUUCUACAAAG
00079557-		ID
ENST000		NO:
00226355-		141
31
ENSG000	1.358393990	SEQ	AAAAACAGCAACUCUAAACUGGCUCUGGAUAGUUC
00079819-		ID	AUAAGCUGUGGCC
ENST000		NO:
00529709-		142
48
ENSG000	1.232028523	SEQ	AGCCUUCGGGCCUUGUAGUAGGUAGCAGUAAACAG
00080503-		ID	CAGAUUUGAGUAUCCACAAUCCUUUCAGUAUUAAA
ENST000		NO:	UUUUCAGUAAAAUAAAAUUACUUGUAU
00634343-		143
97
ENSG000	1.347728768	SEQ	AAAAUAACUAGCAACC
00081051-		ID
ENST000		NO:
00226359-		144
16
ENSG000	1.220437906	SEQ	AUUGUGCUUCCACCACUGCCAAUAACAAAAUAACU
00081051-		ID	AGCAACC
ENST000		NO:
00395792-		145
42
ENSG000	1.428014134	SEQ	AAUUUGAAGGGUUUCUUGUAGAGAGAAAGUCACAU
00082153-		ID	UUUGACGUACAUUUGAUUCAAGUGCAGGGUGUCUU
ENST000		NO:	UU
00419090-		146
72
ENSG000	1.701310135	SEQ	CAGAGGUGCUGUUAUCAGAAUAGUCUUCUGGGUAU
00082269-		ID	AAAUUAAAA
ENST000		NO:
00194672-		147
44
ENSG000	1.114153277	SEQ	GAGAAUCCCGGUGGUGAGCGGGG
00083123-		ID
ENST000		NO:
00320393-		148
23
ENSG000	1.232812987	SEQ	UUUGUUUCUGUCAGGCUGUCCCUGGCCGGGGUUCU
00083814-		ID	GUAACGCUUGUGUGGGCCGCAGGUGGAGGUGUUGG
ENST000		NO:	GAAAGCGCGGAGGAG
00600125-		149
85
ENSG000	1.18233773	SEQ	CCCCUUUGGAGCUACUUCCUC
00084092-		ID
ENST000		NO:
00264230-		150
21
ENSG000	1.759674184	SEQ	GUUUUUCUUUUUUUAAGUAACAAGUAAACCAUACA
00084463-		ID	AAUUGUCAAC
ENST000		NO:
00535638-		151
45
ENSG000	1.155467285	SEQ	GCUGUCCUCUUCAGCUCAAG
00084754-		ID
ENST000		NO:
00645274-		152
20
ENSG000	1.283122656	SEQ	CUGGAAGAGGAUCUUGGGCGCCGCCAGGUUCUGUG
00085063-		ID	GACAAUCACA
ENST000		NO:
00533403-		153
45
ENSG000	2.109716508	SEQ	AUUAUACUUCUUACAGUGAGGAGCCAGAGCUUCCA
00085063-		ID	GGUUCUGUGGACAAUCACA
ENST000		NO:
00652678-		154
54
ENSG000	1.848653664	SEQ	GUGAGAGGACAUUGUGAUAAGUGAAGUGAAAGAGC
00085117-		ID	UUUGUCAGCUGCACAGGUGA
ENST000		NO:
00526958-		155
55
ENSG000	1.611121882	SEQ	ACAGAAAGUAGCUCAUUCCUCCUAACUGGGUAAUA
00085721-		ID	GACAGUGGUGGGGCCUGGAAAAGAUUUCAAAU
ENST000		NO:
00327307-		156
67
ENSG000	1.12826237	SEQ	AGCUACAGCUACCUCCGGACGCUCUCAAG
00086589-		ID
ENST000		NO:
00518917-		157
29
ENSG000	1.107517003	SEQ	CAGAUACUUUGGUGUUGAACAUUUGGGAUAGAAGA
00086666-		ID	GAGAAAUUUAAAAUUAAAAAUUUUCCAUAUUUCUA
ENST000		NO:	UCACAAAUAUUGGUGUGCAACUGAGGAAC
00558087-		158
99
ENSG000	1.599711439	SEQ	AGCUUCAAGUGAAGUUAAUCUGAGGUGAAGCAAAC
00086666-		ID	AGAAAAUUGUGGAGGUUUUGUUGGUGGAGAUAAGU
ENST000		NO:	AAUUAACAUUUCGAAACAGGAA
00558390-		159
92
ENSG000	1.284347896	SEQ	GAAGAGAGAAAUUUAAAAUUAAAAAUUUUCCAUAU
00086666		ID	UUCUAUCACAAAUAUUGGUAAUUUGACAACAGUUA
ENST000		NO:	AUUUGAUUGUCGUCUUAAUAAAAUUUA
00558724-		160
97
ENSG000	1.216464705	SEQ	ACAGCUUCAAGUGAAGUUAAUCUGAGGUGAAGCAA
00086666-		ID	ACAGAAAAUUGUGGAGGUUUUGUUGGUGGAGAUAA
ENST000		NO:	GUAAUUAACAUUUCGAAACAGGAA
00560976-		161
94
ENSG000	1.471574188	SEQ	CAGAUUUGUUUUCCUCUGAGUGGUUUUCAGCUUGC
00086991-		ID	UGGUUAAUUGAAA
ENST000		NO:
00528341-		162
48
ENSG000	2.371610223	SEQ	AAGCGGCGAGUCUCC
00087157-		ID
ENST000		NO:
00589689-		163
15
ENSG000	1.108833409	SEQ	AUAUACGGGCUCCAGGCUGAACGGCUCGGGCCACUU
00087237-		ID	ACACACCACUGCCUGAUAACC
ENST000		NO:
00379780-		164
57
ENSG000	1.362579746	SEQ	UUCAGCAACCCGUCUGAACAGAUCUGGCGUCCUGGA
00087250-		ID	GAAUUCUAGA
ENST000		NO:
00561640-		165
46
ENSG000	1.18848933	SEQ	CGCGCCUUCCUGCGGCUAAG
00087365-		ID
ENST000		NO:
00524627-		166
20
ENSG000	1.595928126	SEQ	ACAAUCUGCCUCUGAAGCUGGAGAUACUAGCUGCA
00087589-		ID	GAGCUCAGGGGAGCUGCUCCACAUCACCGAC
ENST000		NO:
00679529-		167
66
ENSG000	1.129908239	SEQ	CCUUUUAUAAGUAACCUACUACUCCUGCAAUAACA
00087884-		ID	GCAUAAUCUAUUC
ENST000		NO:
00525034-		168
48
ENSG000	1.409121561	SEQ	UUCUGGAGGCUGGGAAGUCCAAGACCAGUUGGCUC
00087884-		ID	GCAUCUGACUUCAGUGAAGUUCCUU
ENST000		NO:
00533193-		169
60
ENSG000	1.355750854	SEQ	CCCGCUUCCAAA
00088682-		ID
ENST000		NO:
00567072-		170
12
ENSG000	1.531612167	SEQ	CAGGAAGCUAGCAGAGUUUGCUUCUGAGACGAAUU
00088756-		ID	CUGUUACAGUACAGUGCAUUUAGUAGGAUCAAGUU
ENST000		NO:	AAUU
00532996-		171
74
ENSG000	1.504027167	SEQ	AUUGCAGCAAGUAAGCCAACAAGGUCUUUUCAGG
00088926-		ID
ENST000		NO:
00264692-		172
34
ENSG000	1.313077944	SEQ	AGAACAGACGUUUGAACAGAGCAGGCUUCUGAGGU
00089012		ID	CUCCAAA
ENST000		NO:
00344103-		173
42
ENSG000	1.138740766	SEQ	GUUGCCACUCUCUCUCCUGUCA
00089127-		ID
ENST000		NO:
00550689-		174
22
ENSG000	1.110939792	SEQ	ACUAUCGCUUACCUACCUCCCUCUGCAGGAACCCGG
00089248-		ID	CGAU
ENST000		NO:
00261735-		175
40
ENSG000	1.294803529	SEQ	GCUAAGUUUUUGGCCGCUUCAAG
00090316-		ID
ENST000		NO:
00264750-		176
23
ENSG000	1.175153364	SEQ	AGCACUCUGACCUAGCAGUCAAC
00090382-		ID
ENST000		NO:
00548839-		177
23
ENSG000	1.26417695	SEQ	CUAGCACUCUGACCUAGCAGUCAAC
00090382-		ID
ENST000		NO:
00549690-		178
25
ENSG000	1.291714013	SEQ	UUAUUUUGGCAGCCUUAUCCAAGUCUGGUACAACA
00090402-		ID	UAGCAAAGAGAACAGGCUAGUAAAUAAG
ENST000		NO:
00476593-		179
63
ENSG000	1.276220722	SEQ	ACAAGCCAGCCAGUCCCUGCAGCUCCACAAACUGAC
00090512-		ID	CCAUCCUGGGCCUUGUUCUCCACAGA
ENST000		NO:
00265029-		180
62
ENSG000	1.113273781	SEQ	CCAACUGGGUCCUGAAGUAGCUGAA
00091844-		ID
ENST000		NO:
00367225-		181
25
ENSG000	1.703707313	SEQ	AUUGCAUCACUGCACUCCAGCUUGUAGUACAGUGA
00092199-		ID	GACAGUGUCUUAAGGAAAG
ENST000		NO:
00557157-		182
54
ENSG000	1.476660275	SEQ	AAGGAGUUCAAGUUGCUUGCCAGACUAACUUACUU
00092871-		ID	UUAAAAGUAAGCAGCCUUCCAAGUUAAGAGAGUAU
ENST000		NO:	UUUAAAUUUCAGAUUUUAUC
00413582-		183
90
ENSG000	1.230131751	SEQ	CAGCCCAUCCACAACCUGCUC
00093010-		ID
ENST000		NO:
00677397-		184
21
ENSG000	1.796093904	SEQ	UUUUUCCAGUGAAACAAAACGUAAGAAUCUGAGUU
00093134-		ID	UGUUUUUCAAAGAUCACUAAAUUUUAGUU
ENST000		NO:
00414302-		185
64
ENSG000	1.10489472	SEQ	UUCUUGGCCUUGGCAAACUUUGGAGAUUGGGGACA
00094841-		ID	GCCAGUAGAGGUGACUUC
ENST000		NO:
00530743-		186
53
ENSG000	1.391468642	SEQ	GCGUCUGAGCAUUGUUAGUCGUUAUUUUCAAGCUU
00095777-		ID	UGCUAACGGUUUUUAAACCUUUGAG
ENST000		NO:
00543632-		187
60
ENSG000	1.308773902	SEQ	UGCAGUUUUUAAGAAGAAAAAGAAGGCCCUGAGUC
00095951-		ID	AAAGAAG
ENST000		NO:
00484210-		188
42
ENSG000	1.627930576	SEQ	AAAACAGGAAAUAGGUGUUUCAUAUAUACGGCUCU
00096006-		ID	AACCUUCUCUCUCUGCACCUUCCUUCUGUCAAUAG
ENST000		NO:
00354620-		189
70
ENSG000	1.424151377	SEQ	ACCUUCCUUCUGUCAAUAG
00096006-		ID
ENST000		NO:
00371159-		190
19
ENSG000	1.423812077	SEQ	AUCUUGCUUGUAGUCCUCUUUCCUUUUCACCUUUCC
00099364-		ID	AUUGUUCCUGACGAGUAGAA
ENST000		NO:
00562798-		191
56
ENSG000	1.107438314	SEQ	ACAGCAGACGUACCCUCCCUCGCUGCCUGCCUGCAG
00099769-		ID	CCUGCCCUGCAGUCAGG
ENST000		NO:
00215539-		192
53
ENSG000	1.488372727	SEQ	ACCAGCCCAGCCUUUCAGUGCAGGCUCCAGCCCUCC
00100362-		ID	ACCCCCACCCGAGUUGCAGG
ENST000		NO:
00216200-		193
56
ENSG000	1.734491128	SEQ	UUAUUACCUCCCUUUUAAAGAGUAGGAAGCUCUGA
00100439-		ID	CACAGAAAAGCUAAAUA
ENST000		NO:
00545034-		194
52
ENSG000	1.217321134	SEQ	AAGAAAUAGAACAGAAUUCAGCC
00100592-		ID
ENST000		NO:
00395125-		195
23
ENSG000	1.442046225	SEQ	AUAUAGUAGUCAGCAACCGGAGGAGUCACGUUGGG
00100625-		ID	GGAACGGCAGAAAGCAGCUAUCCGUUUACACUACU
ENST000		NO:	UUGCUCUAACAGCUAUCUUA
00556952-		196
90
ENSG000	1.181338232	SEQ	GCGGAGGGAGUGGAACCUCGAUAUUGGUGGUGUCC
00100714-		ID	AUCGUGGGCAGCGGACUAAUAAAGGCC
ENST000		NO:
00651537-		197
62
ENSG000	1.166937751	SEQ	CCAGCGAAGACAGGCUGAG
00100767-		ID
ENST000		NO:
00216658-		198
19
ENSG000	1.637845248	SEQ	AGAACCGUUCGCGGAGGAAAGGCGAACUAGUGUUG
00100983-		ID	GG
ENST000		NO:
00643443-		199
37
ENSG000	1.15349591	SEQ	ACAGUUGUGUUGGGCUCACACCAGUGAACCGAAGC
00101162-		ID	UCUGGAUUCUGAGAGUCUGAGGAUUCCGUGAAGAU
ENST000		NO:	CUCAGACUUGGGCUCAGAGCAAGG
00217133-		200
94
ENSG000	1.464676374	SEQ	AGCCUCGUGACCUUUUACCCCAAC
00101452-		ID
ENST000		NO:
00252011-		201
24
ENSG000	1.152621177	SEQ	ACUAGGGCAAUCUGCCGGAAGAGUCAGGUUCUGUG
00101473-		ID	UAGUUCUCCGCGUCUUCCGCGGAGCGGGUGUGCAG
ENST000		NO:	GGCCUGCAGCAUUGAACUAG
00481938-		202
90
ENSG000	1.286831533	SEQ	CCUGGCAAUCCC
00101542-		ID
ENST000		NO:
00536675-		203
12
ENSG000	1.287310106	SEQ	AGUGUUGGUUCAGUAAGUUUUACCAUCAAUUCAAG
00101654-		ID	UAAUCAUAA
ENST000		NO:
00262173-		204
44
ENSG000	1.447930373	SEQ	AAGUAGCGCUGCGGUUGGCAGCGGCGGG
00101751-		ID
ENST000		NO:
00406285-		205
28
ENSG000	1.155649303	SEQ	ACUCUCUGUUCUUGCUAUCUAAGUGCCGCUGCUUCC
00101812-		ID	GCC
ENST000		NO:
00355016-		206
39
ENSG000	1.368781976	SEQ	AAUUUGAGACUCAGCCUAGUCCAGGCAAGCUACUG
00101842-		ID	GCACCUGCUGCUCUCAACUAACCUCCACACA
ENST000		NO:
00217957-		207
66
ENSG000	1.294937074	SEQ	GGAAUCGGGAGAUUCGGGACC
00101868-		ID
ENST000		NO:
00677890-		208
21
ENSG000	1.520470786	SEQ	AGACUGUUCCAAG
00101935-		ID
ENST000		NO:
00372059-		209
13
ENSG000	1.201193262	SEQ	UUACAAGGAUCACAGGGGUUGGUACAAGUUGCUUG
00101974-		ID	AUAAUCUGCAGCAUUCUCUCUGAGAUUUAGCUGCC
ENST000		NO:	AUUGUGUUGCCAAAUUUCUGCAGUUCAGU
00327569-		210
99
ENSG000	1.253705718	SEQ	ACACGCGCCCUACCUCGGAGUGUGUGGCGCCAGUAG
00102021-		ID	UCAGGGAAG
ENST000		NO:
00371920-		211
45
ENSG000	1.924927925	SEQ	GUUAGUUCUACAGAAGAGGCAGAAAAACAAGAGAU
00102271-		ID	AACAAAGGCUCCGUUUCCUUUCUGUGAGAGAAGGC
ENST000		NO:	UUUUGUCUUUCCUCCUGCUACG
00373119-		212
92
ENSG000	1.180478522	SEQ	ACGAGGUGGGCC
00102387-		ID
ENST000		NO:
00372907-		213
12
ENSG000	1.126298746	SEQ	CAGACUGUGGUUUUGUGCUUGCUCACCAAAGCUAA
00102452-		ID	CCUCAGC
ENST000		NO:
00675594-		214
42
ENSG000	1.335722854	SEQ	GGCAGCGGGACGCACCAUUUCAGUUGUGUUCUUGG
00102738-		ID	UUCAUUUCGUGUCUCGGCG
ENST000		NO:
00323563-		215
54
ENSG000	1.716041113	SEQ	AAAGGGGCCUUCAAGAAGAGAGUUCUCAGAGCAGA
00102780-		ID	CUCAGCUUUAGGUGCUGAAAGUAAUUUCUCAAGAU
ENST000		NO:	CAUCACUCCAUUCAGAAGGCUA
00626247-		216
92
ENSG000	1.340489447	SEQ	ACUCAGCCUCCCUUCCCCAGCCGUGACAGCACUGGA
00102891-		ID	GCCUUUCGGACACCUGGACC
ENST000		NO:
00219162-		217
56
ENSG000	1.563641032	SEQ	UUCCUUACCUGCUUUGAGUCUGUGGAAGGAGACAG
00102900-		ID	GAAUUCUGGAUCUGCAUCUCCA
ENST000		NO:
00568656-		218
57
ENSG000	1.663197806	SEQ	CUUGGACCUUGGCCCUCGCUUUCCAGG
00103269-		ID
ENST000		NO:
00219551-		219
27
ENSG000	1.189560838	SEQ	GAGAAUCAGAUUGUGCCCACAAGGCGGAAAGUUAC
00103274-		ID	GACAGCGGGUUCCGGUGACCACGAAGGCGGCAAAG
ENST000		NO:	GCGACGGA
00574334-		220
78
ENSG000	1.267516878	SEQ	AUUCCAUCCCAC
00103356-		ID
ENST000		NO:
00563499-		221
12
ENSG000	1.242641463	SEQ	ACGUGUGCUAUUCCAUCCCAC
00103356-		ID
ENST000		NO:
00564668-		222
21
ENSG000	1.185296402	SEQ	GCAGCAGUUUUCUACGUCUGAAAUUUUUUAGUUCU
00103429-		ID	CUGGAACCCAGAAUUUGCUAAGAG
ENST000		NO:
00566710-		223
59
ENSG000	1.377359015	SEQ	ACAUUAAAAAUAACAUUUUUCUCUCUUGUAGUGUG
00103540-		ID	ACUGUGGGAAG
ENST000		NO:
00396208-		224
46
ENSG000	1.215285335	SEQ	GCUGUCCUAGGAUUGCUGGCUUUUGUUUUUGCUGC
00104081-		ID	UGAGCCUGGAGCUCAGCUCAGACUGAGAGGAGAG
ENST000		NO:
00561360-		225
69
ENSG000	1.224564945	SEQ	GUAGUACGAAUCCGUCAGGCCGGAACC
00104129-		ID
ENST000		NO:
00220496-		226
27
ENSG000	1.564981531	SEQ	UUAAAAAAACAGUUUCCUGCUAGUGCCCUGAAGAU
00104205-		ID	UCCUGCCAAGAGAAUAUUUGGUGAUAAUUUUGAUC
ENST000		NO:	CAGUCCAGAGUUCAGAGCAUUCCUUCAA
00519396-		227
98
ENSG000	1.46221118	SEQ	UGUUGCAGACCCAGGAGUCUCUGAAGGCUUCCGCG
00104221-		ID
ENST000		NO:	GCUUUGGGGCCGGUUGUGAG
00520601-		228
55
ENSG000	1.32565235	SEQ	GAAGACGCUUCCUGGGUUUGAGGAGUUCAGUGACU
00104299-		ID	GCUAUUGAACCACCAAAAGUCCAUU
ENST000		NO:
00522363-		229
60
ENSG000	1.370427866	SEQ	GUGCAAACAUCUCAAGCCAGUUCAGAGUUUGCUGU
00104313-		ID	UUCCUCAAGUUGCAGGUCU
ENST000		NO:
00419131-		230
54
ENSG000	1.16477741	SEQ	CUUUUCUUUGGCAAG
00104408-		ID
ENST000		NO:
00220849-		231
15
ENSG000	1.790039456	SEQ	ACAGACUCCCUUUUCUUUGGCAAG
00104408-		ID
ENST000		NO:
00519627-		232
24
ENSG000	1.361434181	SEQ	AGACUCCCUUUUCUUUGGCAAG
00104408-		ID
ENST000		NO:
00678042-		233
22
ENSG000	1.169183735	SEQ	CUUCCGCGUGC
00104687-		ID
ENST000		NO:
00221130-		234
11
ENSG000	2.021321532	SEQ	UUGGCUGCUAGAGCG
00104763-		ID
ENST000		NO:
00518087-		235
15
ENSG000	1.260127344	SEQ	AGUGGCGUUGGCUGCUAGAGCG
00104763-		ID
ENST000		NO:
00637603-		236
22
ENSG000	1.189060489	SEQ	UGGCGUUGGCUGCUAGAGCG
00104763-		ID
ENST000		NO:
00637638-		237
20
ENSG000	1.346252571	SEQ	ACCCGCAAACCAGAUCGCCGCUCCGGAGCCCCCAGC
00104833-		ID	CCACUGGGAGGGCUCGCGGUUACUGCAAGGAUUCU
ENST000		NO:	GGCGAAGUAGGUCUAAAUAGA
00598635-		238
92
ENSG000	2.107429577	SEQ	ACCCGGAGCGGGAAG
00104853-		ID
ENST000		NO:
00591304-		239
15
ENSG000	1.137899399	SEQ	GGUCCUAAUUCGGGAAACGUGCACCUUGACUAAUU
00104907-		ID	CGGUUUUCUGUGGCUACGAGAGCAGGCUUGGCGGG
ENST000		NO:	CGGAGGCGCCAGCGGAGUUCUC
00592814-		240
92
ENSG000	1.383285769	SEQ	ACACGAUUCUCCAAC
00104980-		ID
ENST000		NO:
00270538-		241
15
ENSG000	1.094498183	SEQ	UCUAGUCCACGCUCGGAGCC
00105193-		ID
ENST000		NO:
00599539-		242
20
ENSG000	1.408944673	SEQ	AACACCCUCCUGGAGG
00105219-		ID
ENST000		NO:
00221818-		243
16
ENSG000	1.419375769	SEQ	GGAAAAGCUCGAUAAUUACCCAGCCUAACCAUUUC
00105248-		ID	UCAGGUGCUUGCGAGGUGAUCAGAAGGCAAAG
ENST000		NO:
00262962-		244
67
ENSG000	3.405465052	SEQ	AAGACGCCAAG
00105278-		ID
ENST000		NO:
00438164-		245
11
ENSG000	1.471425722	SEQ	UAAGACCGGCCCCUUCCGGUUACGAAACCUUAGCAA
00105341-		ID	G
ENST000		NO:
00592922-		246
37
ENSG000	1.252950824	SEQ	CUUCCUUUGACAAG
00105373-		ID
ENST000		NO:
00246802-		247
14
ENSG000	2.147015895	SEQ	ACUCCCUUCCUCUUUUCUGCUCACACAGGAAGCCCU
00105383-		ID	GGAAGCUGCUUCCUCAGAC
ENST000		NO:
00421133-		248
55
ENSG000	1.161684562	SEQ	AGCCUCCAGCGGUGGCUACAGUUGAAACCCUCACAC
00105398-		ID	CACGCAGGAAGAGGUCAUCAUC
ENST000		NO:
00222002-		249
58
ENSG000	1.28954586	SEQ	ACAGCAGCUCUACCCCUCACGACGCAGAC
00105404-		ID
ENST000		NO:
00222008-		250
29
ENSG000	1.196237228	SEQ	GGGUUUGGUGGCAGAAGGAGAGUGUGGGGGAGGCA
00105467-		ID	GGGGUCUUCUCCCUGAUCGUCUUCUCCUCCCUGCUG
ENST000		NO:	ACCGACGGCUACCAGAACAAG
00600863-		251
92
ENSG000	1.127089717	SEQ	CUUCGACUCGCU
00105583-		ID
ENST000		NO:
00596731-		252
12
ENSG000	1.153290946	SEQ	CCCCUGCCUCUGAGG
00105605-		ID
ENST000		NO:
00391766-		253
15
ENSG000	1.209464013	SEQ	AGAGGACACUUCCUUUUGCGGGUGGCGGCGAACGC
00105640-		ID	GGAGAGCACGCC
ENST000		NO:
00222247-		254
47
ENSG000	2.004472198	SEQ	AAGAGGAGCUGGUGAGAAGACAGCGAA
00105669-		ID
ENST000		NO:
00351079-		255
27
ENSG000	1.312591204	SEQ	AUUGUGGGAUUGG
00105705-		ID
ENST000		NO:
00247001-		256
13
ENSG000	1.168007566	SEQ	CCUGUUGCAGCC
00105793-		ID
ENST000		NO:
00439832-		257
12
ENSG000	1.248962899	SEQ	GUGGGAACCUUGACAAGCAGC
00105849-		ID
ENST000		NO:
00222567-		258
21
ENSG000	1.220285281	SEQ	ACUGUGCUCUGCGAGCCGAAUC
00105879-		ID
ENST000		NO:
00222597-		259
22
ENSG000	1.329508674	SEQ	AUAAACAUUGGGCUGCACAUAGAGACUUAAUUUUA
00105954-		ID	GAUUUAGACAAA
ENST000		NO:
00222674-		260
47
ENSG000	1.200722879	SEQ	AUAAAUUGUGCAAGGGUGCUAUAGACGCACAAACG
00106004-		ID	ACCGCGAGCCACAAAUCAAGCACACAUAUCAAAAAA
ENST000		NO:	CAA
00222726-		261
74
ENSG000	1.71541121	SEQ	UAGAUCGUCAGGAAAAGCCUAAAGAUUAGACUGUA
00106028-		ID	AGAAAAGAAAAUAGAAGCC
ENST000		NO:
00465582-		262
54
ENSG000	1.160270956	SEQ	AUCUUUGCAGAUUAUCCUGUGGAAGGAAA
00106245-		ID
ENST000		NO:
00456893-		263
29
ENSG000	1.865183436	SEQ	UACAGCUUUGAUUUUAUAACAUCCUGCUAAUUUUU
00106392-		ID	GUUCUUACAGAAAUACACUUUCGGGAA
ENST000		NO:
00223122-		264
62
ENSG000	1.124579959	SEQ	AAAAUCAAUUCUCACACGCUGGG
00106484-		ID
ENST000		NO:
00458161-		265
23
ENSG000	1.341577069	SEQ	UCAUUGCGGCUGGCGUUCCCAAUACAGACGCAUCGU
00106524-		ID	UUCUUUUUUAAUACUCCCUAAGAAAGGGAAUAACC
ENST000		NO:	UUCAAGCUGGCGGGAGCA
00453623-		266
89
ENSG000	1.112496496	SEQ	CUGGUUCCUCUCGGAGCGGAGACGGCAA
00106682-		ID
ENST000		NO:
00265753-		267
28
ENSG000	1.243776181	SEQ	CAAUUCCUGUCUGGAUUAUAUUGCUUUUUCAUUUA
00106771-		ID	GCAUCCCUGGCUGGCUCAGUGAGAAUUCCAGUAUU
ENST000		NO:	CCUGGUUAUUGUUUUCCUG
00491854-		268
89
ENSG000	1.116866223	SEQ	GAGCCGGAGGAGGUGGAGAGUA
00106785-		ID
ENST000		NO:
00375098-		269
22
ENSG000	1.356659093	SEQ	ACAGCCUGCGGGGAACGUAGCUAGCUGCAAGCAGA
00107201-		ID	GGCCGGC
ENST000		NO
00679771-		270
42
ENSG000	1.456823895	SEQ	CUUCUUGGUGAAUUUUUGGAGUAAGCCAUUAAAUU
00107643-		ID	AAUUGCUUGCCAUC
ENST000		NO:
00360332-		271
49
ENSG000	1.45184235	SEQ	AGUGGUGUGGUACCGGGUACCCGGAGACGUGUAUC
00107651-		ID	GGACGGUGGGCCGCAGCC
ENST000		NO:
00369075-		272
53
ENSG000	1.160501833	SEQ	AAGCUCUUACUGCAGGCAGAUUGAAGCGUCUUACU
00107771-		ID	UUCCGAAAAUUGGAGUGUGACAAU
ENST000		NO:
00493409-		273
59
ENSG000	1.155153638	SEQ	GUGAGCGGCAAC
00107949-		ID
ENST000		NO:
00278100-		274
12
ENSG000	1.114402864	SEQ	AUUUCAACACUACACUUGCACA
00108094-		ID
ENST000		NO:
00374746-		275
22
ENSG000	1.183590449	SEQ	AGUUUGCAGUUGAGCCCAAACUGAAGUCUGUCUGU
00108094-		ID	AGAAGGAAACAACAAACUUUGUACUUU
ENST000		NO:
00421317-		276
62
ENSG000	1.098761062	SEQ	GUUCUCCGUAAG
00108349-		ID
ENST000		NO:
00264645-		277
12
ENSG000	1.323960217	SEQ	AUUGUGCCCUACCAGAGAGGACAGAGUGGCACCGCC
00108352-		ID	UCCAGUGGCA
ENST000		NO:
00456989-		278
46
ENSG000	1.567342301	SEQ	UGCAUUUGGUAUUAGCUAGUGGAAGCAGUAGUUAG
00108375-		ID	UGUUGAAGUGCAUUGCUGCAGCUGGUAGC
ENST000		NO:
00583753-		279
64
ENSG000	1.711817659	SEQ	AGCCGGAGCCGUGGCCUGCGGGGCCGGCGAC
00108433-		ID
ENST000		NO:
00638219-		280
31
ENSG000	1.348128084	SEQ	CUUUAUUAGAGAGAUACUUGUUGACCGACGAAGUC
00108852-		ID	AGUGGGGCAGCCGCUAAGAAUA
ENST000		NO:
00518766-		281
57
ENSG000	1.535761109	SEQ	AUUGGGAGCCUUUGGGGGUUUAUUCUCUUCCCUUC
00108932-		ID	UAACUUGAUUAAGA
ENST000		NO:
00580666-		282
49
ENSG000	1.214309141	SEQ	CACAAUCUACACAGCAGCCUUGAAGGAAAAGACGCC
00109113-		ID	AGACUUCAGACGUCUCUCUCCUCGGGCGCCCUGCAA
ENST000		NO:	GGCCGCAGGCAGG
00412625-		283
85
ENSG000	1.649774593	SEQ	AAAAUAUCAGAGUCACCAGAGACACAAGGCUUGAA
00109163-		ID	GCUCUGUCCUGGGAAAAU
ENST000		NO:
00226413-		284
53
ENSG000	1.585246933	SEQ	AAAAGAAUUAUCACAUUGCACAAGG
00109181-		ID
ENST000		NO:
00458688-		285
25
ENSG000	1.24414818	SEQ	UUAUAAAGCUAAAGAUCACAACUUAUUUUCUAGAU
00109205-		ID	AUAUCAUACGAAA
ENST000		NO:
00396094-		286
48
ENSG000	1.199283504	SEQ	AGAGCUGAGAGAGGAAAAGAACACAGAUCUCGCAG
00109205-		ID	UGUUCAGAUUUUUCUUUUUAGGUCCAGGAGUAAGA
ENST000		NO:	UAUAUCAUACGAAA
00683306-		287
84
ENSG000	1.137668917	SEQ	CCGAGGAGCUGAGGAAGCCUAGAGCUCUCAGAAGC
00109475-		ID	AGUCCUUUGAGCUGGUGUAGGGGCACUCAGA
ENST000		NO:
00394668-		288
66
ENSG000	1.177103964	SEQ	UCCUAUUGGGUUAACACUGGAGGCUCUAAG
00109911-		ID
ENST000		NO:
00639878-		289
30
ENSG000	1.556481021	SEQ	ACAGGGCAGACCUGUAGUGUUCGUUUAUUCCUGGG
00110060-		ID	GUUGUCAUAUC
ENST000		NO:
00530811-		290
46
ENSG000	1.620457185	SEQ	ACCGGCUGAGCC
00110104-		ID
ENST000		NO:
00227520-		291
12
ENSG000	1.441213556	SEQ	GGCUCAGAGAGGUUAAGUGACUCAGCCAAGGUCAA
00110200-		ID	ACAGCUAUCUAGGAGCC
ENST000		NO:
00438939-		292
52
ENSG000	1.692791453	SEQ	UAGUAAGUGGUGGAGCCAGGACUCAAAGCCAGUCU
00110200-		ID	AGGAGCC
ENST000		NO:
00543050-		293
42
ENSG000	1.329757167	SEQ	AUUAUUCUUUUGAAGAUUCUUCGUUGUCAAGCCGC
00110321-		ID	CAAA
ENST000		NO:
00531647-		294
39
ENSG000	2.178657666	SEQ	ACAGCGGCUUCCUUGAUCCUUGCCACCCGCGACUGA
00110484-		ID	ACACCGACAGCAGCAGCCUCACC
ENST000		NO:
00227918-		295
59
ENSG000	1.323790599	SEQ	GUCACUUUCAGUAAUUCAAAGGCAAUUUACCAGUG
00110693-		ID	AUUUCUGGGUGCUGGGGCUGAUAUUUUUUGUGCAU
ENST000		NO:	AUUUAAGA
00396356-		296
78
ENSG000	1.146761652	SEQ	CUUUCGUUGCCUGAUCGCCGCCAUC
00110700-		ID
ENST000		NO:
00228140-		297
25
ENSG000	1.132076128	SEQ	UCCCGAUUGACUGGCCUGCUUGGCAAGGCAAGUAG
00110717-		ID	CGGCGGCGCUUCAAG
ENST000		NO:
00526446-		298
50
ENSG000	1.250931727	SEQ	GUUGUCACUCGACUACCAAG
00110871-		ID
ENST000		NO:
00445328-		299
20
ENSG000	1.331264455	SEQ	ACUAGGCGGUUUGGUAACACG
00110880-		ID
ENST000		NO:
00547294-		300
21
ENSG000	1.254153987	SEQ	CCGGAAUAGUGAGCCCUGGGCGCGGGGGCGGCGUG
00110911-		ID	UCAGGUGGUUGCGGAGCUGAAUCAUAUUCUAAGAA
ENST000		NO:	CUCAGCCACUCAGGUAUCCACC
00546636-		301
92
ENSG000	1.503396046	SEQ	GCGUGUCAGGUGGUUGCGGAGCUGAAUCAUAUUCU
00110911-		ID	AAGAACUCAGCCACUCAGGUAUCCACC
ENST000		NO:
00547198-		302
62
ENSG000	1.261552878	SEQ	ACUGUGGUUCUGCGCUUGUCAUC
00111300-		ID
ENST000		NO:
00549711-		303
23
ENSG000	1.095459425	SEQ	ACAGGGCAGUGUAGUUCCAGAAAAUAGGACUGACC
00111404-		ID	AAGAAGCAGAAAAGCAAG
ENST000		NO:
00538724-		304
53
ENSG000	1.489070215	SEQ	AUUAGUAUCUCUUGGGCUGCUGUGAGUGACACACG
00111536-		ID	CUGAGUGGGGUGAAGGGAA
ENST000		NO:
00229134-		305
54
ENSG000	1.613651694	SEQ	AGGUGAUCAUUUCAAACCAAGCAUCAGCAACAAUU
00111700-		ID	AAAAAUAUUCACUUGGUAUCUGUAGUUUAAUA
ENST000		NO:
00261196-		306
67
ENSG000	1.146171964	SEQ	CUUGGGGACCCUGGACCACUAUC
00111752-		ID
ENST000		NO:
00541181-		307
23
ENSG000	1.132594155	SEQ	GUCCAUCUCAUAGCAGGCACAAACUCAUCCAUCCCC
00112115-		ID	AGUUGAUUGGAAGAAACAACG
ENST000		NO:
00648244-		308
57
ENSG000	1.314688872	SEQ	GAAGAAGAAGAAGCUUUUGAUUGGACAGUCGCUAG
00112118-		ID	UCCGACCUCAGAGAACUCAGCCAAUCAUA
ENST000		NO:
00229854-		309
64
ENSG000	1.438278383	SEQ	AACGUCAUCUAGGAGCACCGAGCAGCUUGGCUAAA
00112651-		ID	AGUAAGGGUGUCGUGCUG
ENST000		NO:
00388752-		310
53
ENSG000	1.185669251	SEQ	AUUAUUUCAUCAUUUGGGCUUGCCCUUUCAGUUGG
00112655-		ID	AGCACUGUGAUUGGACCCAAGUUGGCAAGAGUGGA
ENST000		NO:	AGACCAGGGGACAGAACAGAAAUCCCC
00473339-		311
97
ENSG000	1.365249769	SEQ	CAAACGUGUUUGCGGAAAGGAGUUUGGGUUCCAUC
00112742-		ID	UUUUCAUUUCCCCAGCGCAGCUUUCUGUAGAA
ENST000		NO:
00369798-		312
67
ENSG000	1.184779413	SEQ	AGUUAAAGUAGGAGUUAGUACUGUUCAGUUUUUUU
00112742-		ID	CUUAGAA
ENST000		NO:
00504040-		313
42
ENSG000	1.476021554	SEQ	AGAAGUUUGGCUCAAUUAAGAAACAUCAGGGAGAU
00112851-		ID	AAAUUCAACCCAGUGUGUCUAAAA
ENST000		NO:
00508515-		314
59
ENSG000	1.205223684	SEQ	AAGACUGCAUCCGGCUCCAGGAAAAGCGAGUGGGA
00112874-		ID	UAUCCCAAUCUUUGGACUGCAUCCUGGUUGCCUCUA
ENST000		NO:	CUGUGGUCACCUUUGGGAAGAA
00230792-		315
93
ENSG000	1.359402443	SEQ	CAAGUAUAUUAGCUAGUACAGCACGUAGUAGCCUG
00112964-		ID	GGGUCCUACAGGU
ENST000		NO:
00537449-		316
48
ENSG000	1.281458891	SEQ	ACUUCGGGGCCAAG
00112983-		ID
ENST000		NO:
00450756-		317
14
ENSG000	1.119058459	SEQ	CCUUUUGGUACGCUCCAAG
00113048-		ID
ENST000		NO:
00261413-		318
19
ENSG000	1.273308197	SEQ	GUGAGGCCGACAGCUCCAAACUCCGUCCCCAGUCCU
00113141-		ID	CACUCCUACUCCAAGUG
ENST000		NO:
00502899-		319
53
ENSG000	1.593984875	SEQ	GGAAGACGGCAGUUUGGCGACAUUUCUCGGCCGAA
00113240-		ID	GGGCCAUUUGCUUUUGCGGAG
ENST000		NO:
00611575-		320
56
ENSG000	1.094820619	SEQ	CCUUUCCUUUCCGCGUGUAGA
00113272-		ID
ENST000		NO:
00231198-		321
21
ENSG000	1.520153816	SEQ	ACUUCCGGUUCUCUGUCAGUCGCGAGCGAACGACCA
00113387-		ID	AGAGGGUGUUCGACUGCUAGAGCCGAGCGAAGCG
ENST000		NO:
00265073-		322
70
ENSG000	1.17560556	SEQ	UGCAUCGUUAGCUUCUCCUGAUAAACUAAUUGCCU
00113520		ID	CACAUUGUCACUGCAAAUCGACACCUAUUA
ENST000		NO:
00622422		323
65-
ENSG000	1.140745863	SEQ	AGUCACUUUCUUUGCCAAAGGCAAACGCAGAACGU
00113525-		ID	UUCAGAGCC
ENST000		NO:
00231454-		324
44
ENSG000	1.147296502	SEQ	AUUGGAACUGUCACCCGGAGGACAGGCUGUCAGAG
00113721-		ID	CUGGACACC
ENST000		NO:
00517957-		325
44
ENSG000	1.633358985	SEQ	GUUAAAUCAAUUUCUGUUUGCUUUCUUCUCUUCUC
00113916-		ID	UGUAGGUUUUGAGCAAAAUUUUGGACUGUGAAGCA
ENST000		NO:	AGGCAUUGGUGAAGACAAA
00430339-		326
89
ENSG000	1.256566246	SEQ	AAAGUGCUGAGUUAAAGUACAUUUCUGGAUUUGGG
00113924-		ID	A
ENST000		NO:
00476082-		327
36
ENSG000	1.257047904	SEQ	GUAUUUGAGUUCUACCGUCAGUCCUGGCAUUAUUU
00114013-		ID	CUCUCUCUACAAGGAGCCUUAGGAGCACU
ENST000		NO:
00482356-		328
64
ENSG000	1.242432585	SEQ	CUUUCUUUUCGCCAUCUUUUGUCUUUCCGUGGAGC
00114391-		ID	UGUCGCC
ENST000		NO:
00394077-		329
42
ENSG000	1.52300545	SEQ	UUUCCGUGGAGCUGUCGCC
00114391-		ID
ENST000		NO:
00469605-		330
19
ENSG000	1.231832202	SEQ	GUGUAGUGUUUUGAGUCCGGCUUCCAUUUAGCGUA
00114416		ID	GAAGCAAUUUAAUUUUAAUUAGUUUUUUUCCAAUU
ENST000		NO:	UAGAAGAUAAUAC
00480918-		331
83
ENSG000	1.253039015	SEQ	AAUUUGCGCGCUCUCUUUCUGCUGCUCCCCAGCUCU
00114942-		ID	CGGAUACAGCCGACACC
ENST000		NO:
00415904-		332
53
ENSG000	1.178219002	SEQ	AGUAAGGGUCGUUGGUGGGAAAG
00114988		ID
ENST000		NO:
00434865-		333
23
ENSG000	1.444686796	SEQ	AGAAUAUAACAGCACUCCCAAAGAACUGGGUACUC
00115009-		ID	AACACUGAGCAGAUCUGUUCUUUGAGCUAAAAACC
ENST000		NO:
00358813-		334
70
ENSG000	1.505063683	SEQ	UAAAAUAGCCCUUCUGUUACUGUCCGGGGCUGCGG
00115365-		ID	GGUGAGAGGCCAGGGCUUGCUUCCGGCGUC
ENST000		NO:
00441020-		335
65
ENSG000	1.534506324	SEQ	AGAAGCCAACUCAGACUCAGCCAACAGAGAUUGUU
00115386-		ID	GAUUUGCCUCUUAAGCAAGAGAUUCAUUGCAGCUC
ENST000		NO:	AGC
00233735-		336
73
ENSG000	1.253091384	SEQ	GCGAGUCUCUUUGCGGCGCUACACUAGAGCAGAGU
00115541-		ID	ACGAGUCUGAGGCGGAGGGAGUA
ENST000		NO:
00233893-		337
58
ENSG000	1.802128923	SEQ	AUUUUGUUUUUGUGUUUUUGCAGGGAGGAGCUCUU
00115548-		ID	CCUGCAGGCGUGGAAACC
ENST000		NO:
00427678-		338
53
ENSG000	1.19044608	SEQ	GACAGCUCCGCGAGCCCCCUACAACUCGUUUCCUUC
00115649-		ID	CGUUCACCUUCGCAGGGCGGCGACUGGCGGCGCG
ENST000		NO:
00451647-		339
70
ENSG000	1.165056902	SEQ	AACAGUUCCUAGAAA
00115850-		ID
ENST000		NO:
00264162-		340
15
ENSG000	1.782780655	SEQ	AUUGCAGGGUCUUUCUGAGUUGAUUUCUUAUAGCA
00115896-		ID	CCUCUCAAGAAA
ENST000		NO:
00487695-		341
47
ENSG000	1.389940816	SEQ	AAGUAGAAGAAGCCCUUAGCCUAAGUAAGCGAUAA
00115935-		ID	GAUUUAUCAGCAAGACUGUUGAACGCAUAACUGCC
ENST000		NO:	CAAG
00436221-		342
74
ENSG000	1.791769809	SEQ	AUUGCAAUUCCAAAAGUUGUAAGACGGGAUAUUCU
00116044-		ID	CUUCUGUGCUGUCAAGGGAC
ENST000		NO:
00423513-		343
55
ENSG000	1.144305482	SEQ	AGAAGCGGCAGGAGCAGCGUUGGCACCGGCGAACC
00116106-		ID
ENST000		NO:
00409854-		344
35
ENSG000	1.202555624	SEQ	AAGAGAACCCUCGGCGGCAAG
00116151-		ID
ENST000		NO:
00378531-		345
21
ENSG000	1.168149072	SEQ	CUCUGCAGCAUAAUUUAGGCAUUGGAGGAGCUGUG
00116171-		ID	GUUGUAACACUCUACAAG
ENST000		NO:
00435345-		346
53
ENSG000	1.756620821	SEQ	AGAAAGAGUCUGGUUUCGAGUUUUGGAGAUCCUUG
00116539-		ID	UUUUUUAGUGAACACAGUUCUGUAAAAUUUUCAUA
ENST000		NO:	AGAUUCCUUGGCAAUAACAUACGCUUGUG
00677042-		347
99
ENSG000	1.186342555	SEQ	AUUUUGCCUUUUUGUUAGGUUUCCUAAAGACAAAA
00116747-		ID	AAAA
ENST000		NO:
00367441-		348
39
ENSG000	1.533309333	SEQ	AGUCUCACUUCAGUUCCUUUUGCAGUAAGAGCUCA
00116824-		ID	GAAUCAAAAGAGGAAACCAACCCCUAAG
ENST000		NO:
00369478-		349
63
ENSG000	1.198622228	SEQ	CUUUUUCUAGCCAGGCUCUCAACUGUCUCCUGCGUU
00117091-		ID	GCUGGGAAGUUCUGGAAGGAAGC
ENST000		NO:
00368046-		350
59
ENSG000	1.198255056	SEQ	AGAGCUCCCUGUACUUUCCCAACAGUAUCGCUCUUU
00117118-		ID	AUAUUCAUCGUGA
ENST000		NO:
00491274-		351
49
ENSG000	1.681815645	SEQ	AGAAGGUUUCCGGUUCCGGUGUAACGUUCGGGCUC
00117360-		ID	CGUCUCAGGGGCUGAAGUUUGUGAGGUGUAGUAUU
ENST000		NO:	GAGUCCUGUUUGAGCUAUUGUUCUCUUUUUCCUGA
00324862-		352	AAA
108
ENSG000	1.599803688	SEQ	ACCCCGUGGAGCACGCCGAU
00117481-		ID
ENST000		NO:
00474844-		353
20
ENSG000	1.342415184	SEQ	AUUACCUGGCUGGUGUUUGCUUGUUCUGGAGUGAU
00117682-		ID	CUUCUGACUGGAAAAGAACU
ENST000		NO:
00430232-		354
55
ENSG000	1.149980607	SEQ	CUUGCCUUGCGCUGCGCGCUCACC
00117691-		ID
ENST000		NO:
00366988-		355
24
ENSG000	1.766812098	SEQ	AGAGCAGAGACC
00118194-		ID
ENST000		NO:
00367315-		356
12
ENSG000	1.132807482	SEQ	UCUGUGCUUGAAAUUCUGUGACUCUUCCCUGUAUC
00118260-		ID	U
ENST000		NO:
00457101-		357
36
ENSG000	1.314243435	SEQ	AGCCUGUGCAAGUGAUUUGGGAGAGGAAGGGGAGA
00118263-		ID	GUAGUUAACUGGUUCGGC
ENST000		NO:
00412414-		358
53
ENSG000	1.398087945	SEQ	GAGACGCAGAGGCGGACAAG
00118363-		ID
ENST000		NO:
00263672-		359
20
ENSG000	1.101739656	SEQ	ACAGUGGUGGGGACAACCUGAGUGCUCAGUCGUAA
00118514-		ID	AGAGGAAAGGCAGAAUUUUUCCUUGCU
ENST000		NO:
00367845-		360
62
ENSG000	1.370569545	SEQ	UAGCAGAAGCUCUACAAGUAGUAUUCAUUCAGUUU
00118520-		ID	CUUACUCUGUUGUCCAGGCUAGAGUACAGUGGCAC
ENST000		NO:	GAUC
00672233-		361
74
ENSG000	1.267324767	SEQ	CUUCCUCGCUUUCUCUGUCUCUCUGUCUCUCUCUCU
00118526-		ID	CUCUCUCCCUCGUCCACUCCCCCAAAC
ENST000		NO:
00237316-		362
63
ENSG000	1.256610665	SEQ	GAGGAAGCCGACUAGGCGAAUUCACUUACUGACCG
00118640-		ID	GCCUGGGCUGCUCUGAGAC
ENST000		NO:
00409760-		363
54
ENSG000	1.279088258	SEQ	CAAGUUUUAAGCAAGAAGAAGGAAAAACUGACAGA
00119397-		ID	AGAGCUUCAGAAACUACAGAAAGACAUAGAG
ENST000		NO:
00373844-		364
66
ENSG000	1.428293972	SEQ	ACCAGUAAGUCGUGUAUUUAGCAUUCAUUCAUCAA
00119403-		ID	AGCCUCCGGAGUCCUCCUACGUGCCCUGCACU
ENST000		NO:
00616568-		365
67
ENSG000	1.296681277	SEQ	GUAGGUGAGCUCGUGAAACAAUAGUAAGAGGAGAA
00119487-		ID	AAUAGCCUUUUAAGGAAAUUGGCCCACAGAAAGG
ENST000		NO:
00373498-		366
69
ENSG000	1.145538231	SEQ	CAGGCCCUCAUCACCUUUUUUCAAGUCAAGAUUUCA
00119508-		ID	UCCCAUAC
ENST000		NO:
00330847-		367
44
ENSG000	1.168101099	SEQ	UUCUUUCCCGAGCUUGGAACUUCGUUAUCCGCG
00119655-		ID
ENST000		NO:
00434013-		368
33
ENSG000	1.176659639	SEQ	UACGCCUCUUCAUUCCCGUCC
00119950-		ID
ENST000		NO:
00650752-		369
21
ENSG000	1.143186536	SEQ	AUAAGUUCCUAGUUAGACACAGGACCUGCUGGGCC
00120160-		ID	ACAGAAAGGAGGCUCUGGGUAGACGCACUAGAUUA
ENST000		NO:	CUGGAUAAAUCACUUCAAUUUCCCA
00380032-		370
95
ENSG000	1.354852912	SEQ	UAGCUCAGUGUUGACAGCUCAGAGAGAGAAAGAUC
00120868-		ID	UGAGGGAAG
ENST000		NO:
00552268-		371
44
ENSG000	1.166143999	SEQ	CGCUGCACUGUCUCUCCGACGCAAGACUGUCCCGGC
00120963-		ID	CCGGAU
ENST000		NO:
00523146-		372
42
ENSG000	1.408580833	SEQ	ACAGAAGUUAGCCACCUUUCUUAACGGUCCGGGAA
00121207-		ID	ACCAGAGGUCUCUCCAGCUACUCAGGG
ENST000		NO:
00507827-		373
62
ENSG000	1.55909511	SEQ	GUGUAUUUGAAUAAACCAGGUUGGCAAAUCAUACU
00121270-		ID	AUAGCUGAAAGAAUUGGCAGGAACUGAAA
ENST000		NO:
00353782-		374
64
ENSG000	2.05704384	SEQ	GUCUAAGAGGCAGACAGAUACAUUGUUCUUCACUG
00121381-		ID	GUCAGCUGAAAGUCAAUUCAUCAUCAGUGAUAUUC
ENST000		NO:	AAAAAUCACAAGUCUUUGCUGGC
00240691-		375
93
ENSG000	1.219648877	SEQ	AUUGCUGCAGACGCUCACCCCAGACACUCACUGCAC
00121410-		ID	CGGAGUGAGCGCGACCAUC
ENST000		NO:
00263100-		376
55
ENSG000	1.257256177	SEQ	GUUGUUGUAGUUCCGAGAGACACGUGAGGUUCUGC
00121749-		ID	UACGUCAUUACCAGGCACGCGCAGGAAAC
ENST000		NO:
00550746-		377
64
ENSG000	1.400484744	SEQ	ACAAAUCAAUCCACGGGUACAGAAGUCUGACUUCCC
00121871-		ID	GACACUCAAUUUCACAGGGUGUCUCUUGAAGAGCU
ENST000		NO	GCCAGUUUUGUAAUCAACCACGAACG
00497724-		378
97
ENSG000	1.129313299	SEQ	UAAUUCGCCAAA
00122026-		ID
ENST000		NO:
00483765-		379
12
ENSG000	1.123234948	SEQ	AGCCUUGUUCAGACGCCCAGUGACCUGCCGAGGUCG
00122136-		ID	GCAGCACAGAGCUCUGGAG
ENST000		NO:
00371776-		380
55
ENSG000	1.374253728	SEQ	UAUAUUGAGAGUGUCCACGUCUCCUCGCUGAACCU
00122257-		ID	UAGGAAUCCCUUGGCACC
ENST000		NO:
00646282-		381
53
ENSG000	1.362705352	SEQ	AGGCGGUGGGGCCCACAGCC
00122481-		ID
ENST000		NO:
00263893-		382
20
ENSG000	1.297662757	SEQ	GUCUGGCUAAGUUUGACAAUAGUGGAAAGUGACAA
00122507-		ID	GAUAAAAUAAUUGUGGGUAGCUUU
ENST000		NO:
00425508-		383
59
ENSG000	1.485480999	SEQ	CUGGUGUAGCUCGUCCGGUUACCUUCAGGAAGAUU
00122643		ID	GGAUAACCAAGAA
ENST000		NO:
00643244-		384
48
ENSG000	1.14985107	SEQ	AGUUUUCUUGGAGGCUUUUUUGGUCCAAUUUGUGA
00122958-		ID	GAUCGAUAUUGUUCUUAAGUAGUGGGAAACCAGGA
ENST000		NO:	AA
00489794-		385
72
ENSG000	1.659647385	SEQ	UAAAUAUUUUUUGCUUUAGUUUUUCUUAUAAGGCU
00123219-		ID	AAAAAUUCACAAAGCAUAUAUCA
ENST000		NO:
00242872-		386
58
ENSG000	1.097159879	SEQ	GAGAGUCAGGUGGAUUCUUGGGCAUUUGCUAUUAA
00123561-		ID	CUUCCUUCCAAA
ENST000		NO:
00372563-		387
47
ENSG000	1.754687177	SEQ	ACACGCCUUUCUUAUUGGAUACCGGCUUUUCAGUG
00124155		ID	GGCCGAGCGCCGCUGGGUAGGCGGAAGUAGCCGCA
ENST000		NO:	GGC
00279035-		388
73
ENSG000	2.111689527	SEQ	AAGUAGCCGCAGGC
00124155-		ID
ENST000		NO:
00638953-		389
14
ENSG000	1.283329662	SEQ	CUUUCCUGCCUCUGAUUCCGGGCUGUC
00124194-		ID
ENST000		NO:
00342560-		390
27
ENSG000	1.310536821	SEQ	ACGACAACUUCCGGAAGAGGUCGCC
00124217-		ID
ENST000		NO:
00244051-		391
25
ENSG000	1.565674628	SEQ	UGAGUUUGGGUCAAUCAGUUUCUCAAGUUAUUUAA
00124279-		ID	CCAGUUGUUUUUAAAUUUUUUAAUUUAGUUAUCAA
ENST000		NO:	AUUGAGAAUCUGAGUGU
00507036-		392
87
ENSG000	1.12182243	SEQ	AACUGAGUCAGUUGAAUUACAUAUCUCCCUGAUAG
00124564-		ID	GUGAAAACCAUUCACUAGGAGAGGAGAAACACA
ENST000		NO:
00449356-		393
68
ENSG000	1.402410839	SEQ	AGUCUGUUCUGACAGUUUGAGAUUACUUAUUGUCU
00124575-		ID	UUUCUGGGAAGACAAAAAC
ENST000		NO:
00244534-		394
54
ENSG000	1.567524235	SEQ	GCAUCCUGCUUCGUCAGGUUUAUACCACUUUAUUU
00124610-		ID	GGUGUGCUGUGUUAGUCACC
ENST000		NO:
00244573-		395
55
ENSG000	1.384338821	SEQ	CCGGACCCUGCAGCCGCAGAG
00124614-		ID
ENST000		NO:
00344700-		396
21
ENSG000	1.234780887	SEQ	ACGCUGUUUUUCCUUUUCGUUGGCGCUUUAUAGCU
00124635-		ID	ACACAGUGCU
ENST000		NO:
00339812-		397
45
ENSG000	1.097694872	SEQ	GAGACAGAAGGUUGUGUUGGGGAACUGAAGGAGUU
00124641-		ID	UCUGUGGGCGGACAGGGAACCCUGCGUUUCUACUG
ENST000		NO:	UGUGAUUCUGCCACCUUCCUGGCCCGACGCC
00409312-		398
101
ENSG000	1.449876957	SEQ	AACAGUUUGAGCUCUGGCAUAGAAGAGGCUGGUGG
00124762-		ID	CUAUUUUGUCCUUGGGCUGCCUGUUUUCAGGCGCC
ENST000		NO:
00615513-		399
70
ENSG000	1.173610821	SEQ	CGGAGCCGCCGAGAGCCUUAGCCGACGGAAACUGGA
00124783-		ID	CACUGGACCGGCAGCGCC
ENST000		NO:
00489567-		400
54
ENSG000	1.23925685	SEQ	UAGUAAAGUGUUCAAGCUGGCUUAUUCAGGUCUGC
00124818-		ID	UGAGAUCUCUACUGGUUUGCUUUUCAGAUCCCUCG
ENST000		NO:	UGGUUCGAGAACAGA
00489301-		401
85
ENSG000	1.855733836	SEQ	ACAGCAACUUCCUUGAUCCCUGCCACGCACGACUGA
00124939-		ID	ACACAGACAGCAGCCGCCUCGCC
ENST000		NO:
00244930-		402
59
ENSG000	1.58350479	SEQ	AAAGGAUCAAGCAUCCCUGAGUUUCAAACAGAAAC
00125363-		ID	UUGCACUGAAUACAUUCAAAGAACCAUCAAGAA
ENST000		NO:
00348912-		403
68
ENSG000	1.692324353	SEQ	UUACUUUCUUACUCUUGGGUCAGUUCCUGCUACAG
00125434-		ID	CUAUCCCACC
ENST000		NO:
00380067-		404
45
ENSG000	1.428100736	SEQ	CUCAACAGCAGCACUUCCGGGUUGGGAGAAAGGUG
00125482-		ID	GCGGCGCUUUCGGAGGGAAUAAA
ENST000		NO:
00334270-		405
58
ENSG000	1.302825379	SEQ	AACAACAUCCUGGGAUUGGGACACACUUUCUGGGC
00125551-		ID	ACUGCUGGCCAGUCCCAAA
ENST000		NO:
00410086-		406
54
ENSG000	1.294196952	SEQ	CUUCAUUCCAUUUUCUGUUGAGUAAUAAACUCAAC
00125571-		ID	GUUGAAA
ENST000		NO:
00349806-		407
42
ENSG000	1.552818327	SEQ	ACACAUCCGGGCUUCUGCUACUAGUGAGAGGAAG
00125676-		ID
ENST000		NO:
00355725-		408
34
ENSG000	1.129692343	SEQ	CCGGCGUUCAAG
00125691-		ID
ENST000		NO:
00394332-		409
12
ENSG000	1.135389126	SEQ	CCUUUUUUCUUUUUUCCGGCGUUCAAG
00125691-		ID
ENST000		NO:
00577407-		410
27
ENSG000	1.125753565	SEQ	CUCAACACUGGGUCAGAAGUCACGGCCAGACAAGA
00125775-		ID	AACGGGGUGUUCUGAGAAUCAGCC
ENST000		NO:
00339987-		411
59
ENSG000	1.10603883	SEQ	CUGAGGAGUACAGAGAACACUCUUCCUGUUCCUCU
00125831		ID	GCAGCUGAAGG
ENST000		NO:
00377007-		412
46
ENSG000	1.606487715	SEQ	AGAUUCAAGGCUUCCUCUCUGGCACCCAACC
00125903-		ID
ENST000		NO:
00246105-		413
31
ENSG000	1.191481023	SEQ	UCCGCUGUGGUCAUUUAGGAAAUCGUAAAUCAGUU
00126091-		ID	GAAG
ENST000		NO:
00645165-		414
39
ENSG000	1.101837922	SEQ	UUUAGGAAAUCGUAAAUCAGUUGAAG
00126091-		ID
ENST000		NO:
00646686-		415
26
ENSG000	1.271196805	SEQ	ACAGUAGGUAGGAAGUCUCAGAGGAAGGAGCCCCU
00126467		ID	CCCUGGGAGCCAGACCCCCACACC
ENST000		NO:
00246801-		416
59
ENSG000	1.827283611	SEQ	ACAUUGUGUCUAUUGUAUCCCUUGGCUGGUGUAUU
00126970-		ID	UGUACAUCUCUCGGGACGUGAAAUUGACAGUGAAA
ENST000		NO:	AGU
00374839-		417
73
ENSG000	1.756976608	SEQ	AAGUGAAUAACCAAGUUUAACCUGUUUUAAUUGAA
00127328-		ID	UUGCAUUUUGACGAAUUAUCAAUAAAA
ENST000		NO:
00550847-		418
62
ENSG000	1.829718954	SEQ	UCAGUGAGGAGAUUCUAGUUAUCAACAGAAAGAAC
00127362-		ID	AAAGAUCAGGGCUGCCUAAUUGCUGAC
ENST000		NO:
00247879-		419
62
ENSG000	1.281544561	SEQ	AGUGGUUGAUUCUUCACCACACUGAAACCAUUAGG
00127483-		ID	AAAAAUCCUUGUGGUUAACAGCAGAGGCUUCAGAG
ENST000		NO:	UGUAACCUGUACUCGGGCCUAGAAAUUAUUUAAA
00312239-		420
104
ENSG000	1.441516297	SEQ	UAUAGCCUUGCAGAACUUCUACUUGCCUGCCUCCCU
00128218-		ID	GCCUCUGGCC
ENST000		NO:
00398465-		421
46
ENSG000	1.271370506	SEQ	AUUGCAGCCUCCCUGAUUCCAGAAGGUACCUUGGU
00128242-		ID	GUCUGAG
ENST000		NO:
00427899-		422
42
ENSG000	1.343106118	SEQ	AUACUGCCUUCCUGUA
00128245-		ID
ENST000		NO:
00420430-		423
16
ENSG000	1.322318192	SEQ	AUAAAUACAGCUUGACUCAGCCACUGUAGUACUGA
00128510-		ID	CUCCCCGGGGAC
ENST000		NO:
00445470-		424
47
ENSG000	1.198048305	SEQ	UCUCUACCUGGAAAUUGGUACAGAGAUUCAGAGUC
00128519-		ID	UUUGUCCAGGAAGACACUUUGGAGUAGAAGA
ENST000		NO:
00249284-		425
66
ENSG000	1.22100676	SEQ	ACGCACAGUUGUGACCAUCAAGU
00128536-		ID
ENST000		NO:
00496633-		426
23
ENSG000	1.499517508	SEQ	UUGAAACCGGGAAGUUUGCUCUAACAUUUCCAGAG
00128573-		ID	AAGGUAUUAAGUC
ENST000		NO:
00393489-		427
48
ENSG000	1.541931367	SEQ	GUGAGUCUGGGAUUGAAUUUUCCUAGGACUCCGUU
00128573-		ID	UCAAGGUUAAUUCGAAAGUCUUGUGGAAGAUCUGG
ENST000		NO:	AAGAAACAGGUAUUAAGUC
00634623-		428
89
ENSG000	1.400013537	SEQ	CUAGAGAGUUCAGCCUACAAAGGACACAAUCUCUC
00128710-		ID	UUCUUCAAAUUCUUCCCCAAA
ENST000		NO:
00249501-		429
56
ENSG000	1.285459599	SEQ	CUGAACGGAGUCCACACAGGCAGACUUGACCUUGAC
00129170-		ID	CAGAUAGUCUUCAAG
ENST000		NO:
00647990-		430
51
ENSG000	1.234745603	SEQ	CCUUUCUCCUGCAGCC
00129221-		ID
ENST000		NO:
00571740-		431
16
ENSG000	1.989152396	SEQ	ACAGCGUUGUGCAAAGUAAGUCCUUCCACUGAACC
00129317-		ID	GAGGCACUGUUAUAGAAGA
ENST000		NO:
00553166-		432
54
ENSG000	1.236668508	SEQ	ACAGAACCGCC
00129347-		ID
ENST000		NO:
00312962-		433
11
ENSG000	1.501828781	SEQ	AAGGAACUCUAUCACAAUUUGAAAAGAUAAGCAAA
00129351-		ID	AGUUUGAUUUCCAGACACUACAGAAGAAGUAAAA
ENST000		NO:
00250241-		434
69
ENSG000	1.644735004	SEQ	AUAGAGUUGAAGUAUUGAUAACACCAAGGAACUCU
00129351-		ID	AUCACAAUUUGAAAAGAUAAGCAAAAGUUUGAUUU
ENST000		NO:	CCAGACACUACAGAAGAAGUAAAA
00587505-		435
94
ENSG000	1.38430594	SEQ	CUCUUCCGUCGCAGAGUUUCGCC
00129824-		ID
ENST000		NO:
00250784-		436
23
ENSG000	1.601091851	SEQ	AUACCUUAGACCCUCAGUC
00130173-		ID
ENST000		NO:
00252453-		437
19
ENSG000	1.325354514	SEQ	ACACUCGCGGCACAGGCUGACAGUAUUGUCGGGGG
00130224-		ID	CUAUUCUCUCUCCCAGGAAC
ENST000		NO:
00317135-		438
55
ENSG000	1.227032478	SEQ	AGUCUAGGGAAAGUCAUUCAGUGGAGUUGAUCUUG
00130234-		ID	GCUCACAGGGGACG
ENST000		NO:
00252519-		439
49
ENSG000	1.639319664	SEQ	ACACAGCUUCUUGGUGCUCCAAAGACGGGCGGUAG
00130592-		ID	GAGGAAGAUCAAAGAAGCGAGAAAGUG
ENST000		NO:
00457279-		440
62
ENSG000	1.706803609	SEQ	AUUUUAGGCAGCUAUUGCUUCAGAAGUCACAGUCU
00130638-		ID	GUUCCACCAGCCUUUGCCAAGG
ENST000		NO:
00402380-		441
57
ENSG000	1.16505064	SEQ	GUUGCUGCCGCG
00130731-		ID
ENST000		NO:
00397666-		442
12
ENSG000	1.153743825	SEQ	AGCUUCUCCUGGGCCGGCGCC
00130943-		ID
ENST000		NO:
00253255-		443
21
ENSG000	1.3496519	SEQ	AUUCAUCUUCCAGGCUCUCCUUCCAUCAAGUCUCUC
00131015-		ID	AUCCCUAGCGCUCUGGGUCCUUA
ENST000		NO:
00367351-		444
59
ENSG000	1.61688911	SEQ	GAAGAGUAACGCUACUACUUCUGUUUCCUUUUGAG
00131018-		ID	UCUGCUCUGACACCCCGGUGGGGGAA
ENST000		NO:
00537033-		445
61
ENSG000	1.367433332	SEQ	CCGAACACGAGCACCACAGGCGCCCGAAGGCCGGAA
00131051-		ID	CAGGCGUUUAGAGAAA
ENST000		NO:
00416529-		446
52
ENSG000	1.117929139	SEQ	AGCAGAGCCAGAGCAGG
00131095-		ID
ENST000		NO:
00588037-		447
17
ENSG000	1.472465384	SEQ	AGUCUCUGAAAACUCUUCAGACACUGAGGGGCACC
00131203-		ID	AGAGGAGCAGACUACAAGA
ENST000		NO:
00253513-		448
54
ENSG000	1.196423496	SEQ	AGCUUCCGGGUUUCCUGGGCUACUACG
00131475-		ID
ENST000		NO:
00253794-		449
27
ENSG000	1.289764047	SEQ	CUAGCGGCUCUCCCCGCGUCCAAG
00131558-		ID
ENST000		NO:
00253861-		450
24
ENSG000	2.021349727	SEQ	GCGGGGCCUCUACCGGCCCG
00131778-		ID
ENST000		NO:
00369258-		451
20
ENSG000	1.856306094	SEQ	AAACCAAAUACUCAGCUGCGUUAGGAAUUCCUUCU
00131981-		ID	GAUUCUUGCUGCAGGAAA
ENST000		NO:
00553493-		452
53
ENSG000	1.500074403	SEQ	GCAUUGCCGUUUUUGCUCAGAAUCGCGACUAAGGC
00132141-		ID	UUUUUUUUUUUCUCCCUCUGAACGGUUAGGCU
ENST000		NO:
00314144-		453
67
ENSG000	1.568651568	SEQ	AUUGCCGUUUUUGCUCAGAAUCGCGACUAAGGCUU
00132141-		ID	UUUUUUUUUCUCCCUCUGAACGGUUAGGCU
ENST000		NO:
00436961-		454
65
ENSG000	1.405876675	SEQ	ACUUCAAGUCUUUUUCUUUUAACGGAUUGAUCUUU
00132170-		ID	UGCUAGAUAGAGACAAAAUAUCAGUGUGAAUUACA
ENST000		NO:	GCAAACCCCUAUUCCAGUCUGUU
00683699-		455
93
ENSG000	1.533415588	SEQ	GUUUCAGUUUGAAGAAAAUCAGUGUUGGGGUUGCA
00132185-		ID	GGAGACCUAAACACAGUCACC
ENST000		NO:
00367957-		456
56
ENSG000	1.274076278	SEQ	ACAGUCUCUGCAGAGAAAUCAAAG
00132300-		ID
ENST000		NO:
00409783-		457
24
ENSG000	1.421294695	SEQ	AUCUUUCCAGCCUCAGUCGGACGGGCGCGGAGACGC
00132341-		ID	UUCUGGAAGGAACGCCGCG
ENST000		NO:
00541679-		458
55
ENSG000	1.129460196	SEQ	AAAAAAGCUCUGUGCUGGCUGGAGCCCCCUCAGUG
00132386-		ID	UGCAGGCUUAGAGGGACUAGGCUGGGUGUGGAGCU
ENST000		NO:	GCAGCGUAUCCACAGGCCCCAGG
00571360-		459
93
ENSG000	1.119292049	SEQ	AUCAGCAAGCUCCAGUGCUACGUGUCCCUGGCAUUU
00132432-		ID	UAGGUGUCGGUUGGGUAGGCAGUC
ENST000		NO:
00352861-		460
60
ENSG000	1.219214634	SEQ	GAGUUCUGAUUUGAAGACUAAUAGUAAUAUAUCUA
00132465-		ID	GUUUUUCAGAAGAAGUGAAGUCAAG
ENST000		NO:
00510614-		461
60
ENSG000	1.403220563	SEQ	UUGGAGAGACU
00132471-		ID
ENST000		NO:
00591831-		462
11
ENSG000	1.376167926	SEQ	CCGAAAGCCUGCAGAGAGCAGAAC
00132530-		ID
ENST000		NO:
00576724-		463
24
ENSG000	1.197074799	SEQ	AAAAGAGCUUAAAAAGUAAAACUGUGCUUUGUCCU
00132604-		ID	AGACUGUUCCUUUGAU
ENST000		NO:
00566257-		464
51
ENSG000	1.146047515	SEQ	AAAGCGUGGCAGCGCAGGCGCAAGCGCAGAGAGCG
00132716-		ID	GAGGCGGUGGUGGUGGCGGCCGCUGGCCAGUGCUG
ENST000		NO:	GCUACAGCAAACAUCAUUCAAG
00447377-		465
92
ENSG000	1.236696574	SEQ	CAGCGCACCAGGUGUCUUUAAGAGUGAUUGAAGAG
00132849-		ID	AAUAAUUCAAA
ENST000		NO:
00635023-		466
46
ENSG000	1.334296863	SEQ	GGCGAGGAGAGGCACACCACUAUUGUUUUAAUUUG
00133027-		ID	CUUUUACCUGAUUCCUGGCAGACUUCUGCGUU
ENST000		NO:
00395782-		467
67
ENSG000	1.194767908	SEQ	UCCUAUUCAUUCUCUUGAUUUUUUUUAAAGAAAAC
00133067-		ID	UUCUUUUGAAAAUUUCCAUCCAAUUCCAAACAAGC
ENST000		NO:	UAGGACGAACAAAGGGACCUCAGC
00423542-		468
94
ENSG000	2.706005771	SEQ	AGCGAUCUCCGAGCGAGGCGGCAAG
00133226-		ID
ENST000		NO:
00323848-		469
25
ENSG000	1.405632638	SEQ	AAUUUAAGGCUGGACACAGAGUCAGCAACACACAA
00133328-		ID	GACAUCAUCUUGAAGGAAGG
ENST000		NO:
00255695-		470
55
ENSG000	1.229968723	SEQ	AGUAAAGGCAAAGUACUUUUCAAACAUUCUGCAGC
00133424-		ID	UGGGAGUACUUCUUUUUUUAAUUUUUUAAAAUAGU
ENST000		NO:	UCAAGGUGAUUUGUAAUCCACAGCAAA
00674780-		471
97
ENSG000	1.954195587	SEQ	ACAGAGCUAGCCGGACGUCCUCCGACUCAAGAUAUU
00133731-		ID	UGUCAAAUAUUUUCAGAAG
ENST000		NO:
00519816-		472
55
ENSG000	1.437882414	SEQ	AUAUUCACCCUUCAGUAGGAGUAGCACAGAGCAAG
00134042-		ID	AAGCUAGCCACGCUGGGCUCCUCAUUGCCUAGCUCA
ENST000		NO:	GUUCC
00588444-		473
76
ENSG000	1.289162858	SEQ	UUUCCAGGUUAACUAAGGUCUCAGCUGUAAACCAA
00134121-		ID	AAGUGAGAGGAGACAUUAAGAUUUUCAUUCUUACC
ENST000		NO:	GGGUUGUCUUCUUCCUGAAGAGCA
00620033-		474
94
ENSG000	1.356759582	SEQ	AAAGCAGUGGUGUUUUACCACUCUGCAGAGAAAGC
00134215-		ID	UAAGGUUGCUAACCAAACAAAAUAACUUUACACUG
ENST000		NO:	ACA
00415432-		475
73
ENSG000	1.347501055	SEQ	ACUCAACCUCUGAAGUUUAGUGACACUAUUGGGAC
00134256-		ID	GAAAAAGGACUGUGCUGGCCCAA
ENST000		NO:
00682167-		476
58
ENSG000	1.148492689	SEQ	GGAAAAAGCAGUACAUUUAGAAGUAGAAGACUUAG
00134352-		ID	CUUCAAAUCCCUACUCCUUCACUUACUAAUUUUGUG
ENST000		NO:	AUUUGGAAAUAUCCGCGCAAG
00522633-		477
92
ENSG000	1.438008154	SEQ	CAGUGCAACUGAAACUUUUGCAUUACUAUACUACU
00134365-		ID	GAGAAUAUCUAAC
ENST000		NO:
00367418-		478
48
ENSG000	1.150004902	SEQ	UUUUGUCUUCCUUGAACAGCCACA
00134419-		ID
ENST000		NO:
00576436-		479
24
ENSG000	2.277302108	SEQ	GCAAAUACUAGUAGAAAAGGUUAUUGGAAUUCUGU
00134480-		ID	UCGGUGUUUAAGCCAGCA
ENST000		NO:
00508855-		480
53
ENSG000	1.994580395	SEQ	ACACAUUUUAGGUAGUUGAUUAGAAAACAUACUUG
00134489-		ID	UCAGAAUUGUCUGGCUGGAUUAAUUUGCUAAUUUG
ENST000		NO:	ACCUUCUUCAUCAUUUGAGUUG
00256906-		481
92
ENSG000	1.777013002	SEQ	CUUCAAGAUUAUCAAUAAUCGGAGAUACGUAUAUU
00134588-		ID	UUAUUUGUAAAGAAAAC
ENST000		NO:
00370832-		482
52
ENSG000	1.25325593	SEQ	CAGGGCCCGUGUUGUGCUUUUGGCCCAGGUAGGUG
00134668-		ID	GACAGAC
ENST000		NO:
00533231-		483
42
ENSG000	1.882459719	SEQ	UUCAAAGAAUAUAGAGUGUUUUGAAAAGUUCAGUC
00134769-		ID	UGUCCCUUCAUUGAAUUUUAGA
ENST000		NO:
00598142-		484
57
ENSG000	1.102219776	SEQ	AUUCUCAGCGCUGAUUUUGAG
00135052-		ID
ENST000		NO:
00470762-		485
21
ENSG000	1.283815746	SEQ	ACAUAUCCCAGGAGGCAAGUCGCAGGGGAGCACGG
00135205-		ID	AAUCGUGAAAA
ENST000		NO:
00415750-		486
46
ENSG000	1.496409599	SEQ	GGAGACAGAGAUCCCAGGACAAAGUUGCAGCAGGC
00135248-		ID	CCCUGAGCAGUUGUAGAA
ENST000		NO:
00315184-		487
53
ENSG000	1.178726176	SEQ	CAGAUAGAUUUUUCUCCCAGC
00135297-		ID
ENST000		NO:
00680758-		488
21
ENSG000	1.400766672	SEQ	GUUGCUUGGACUUGGCCCUAUUCUGUAUCAGGUCG
00135314-		ID	GAGCAGAGC
ENST000		NO:
00610330-		489
44
ENSG000	1.964019989	SEQ	UUCUCACCCUGCCUUUGUUACUGGGAAACCGAACGC
00135373-		ID	GGCGCUGUGGCUUUCAGCUUGGAUC
ENST000		NO:
00529527-		490
61
ENSG000	1.690695667	SEQ	CCCUGCCUUUGUUACUGGGAAACCGAACGCGGCGCU
00135373-		ID	GUGGCUUUCAGCUUGGAUC
ENST000		NO:
00531728-		491
55
ENSG000	1.931349561	SEQ	GAUAUUUGGUCUUUGCCUGGCUGAGGGACACAAAG
00135525-		ID	CAAGAAGAGGGAGACAGUCAGAUAGUUUGCAGGAU
ENST000		NO:	AUUCAAGAAAGAAGGAUUUUAGC
00544465-		492
93
ENSG000	1.296682686	SEQ	AAUACUGGGAUCUUCAGUGGCAGGAGGAGUAAUCA
00135605-		ID	GAAGACGGAG
ENST000		NO:
00505452-		493
45
ENSG000	1.225110078	SEQ	AUUUCCCUUUUUACCAAGAAGAAAGAUUUGUUCAG
00135905-		ID	CCUGGUGACGCUUCAGAAGAGAAGAGUUUAACGAC
ENST000		NO:	AUUGAUAUUUUGAAAUAUUUUGUGACUCAAAUUAU
00409592-		494	AGCAAUACG
114
ENSG000	1.663519082	SEQ	ACUGUUUUGCAAACAUAGCAUCAACAUAGAAGUUA
00135905-		ID	UUUUGUAGGCUCCAGGAGUCAGCG
ENST000		NO:
00644695-		495
59
ENSG000	1.388582632	SEQ	AACGCUUCCUUCGCGGGGCUUUGUGGGUAGCCGAC
00135974-		ID	UGGGGUCUCCUGGCGACGACC
ENST000		NO:
00410049-		496
56
ENSG000	1.196904506	SEQ	UAGAGAGAGGAA
00136002-		ID
ENST000		NO:
00355771-		497
12
ENSG000	1.445754515	SEQ	CAGAGAGUUCGGCUUAUUUAUAGGAAUUGCUUGAA
00136144-		ID	GCCAGAGUC
ENST000		NO:
00258646-		498
44
ENSG000	1.171193993	SEQ	CAGUCAUUCCCUUGUAGGGACAACUAGAAGAAAUU
00136261-		ID	UU
ENST000		NO:
00446596-		499
37
ENSG000	1.312722487	SEQ	AGAAAUUCUGCAAAAUAAGUUGGUCUCUAGGAUAC
00136273-		ID	AUAAGUUGCAUUUUAGUAAUUCCUUAUUUUAACCC
ENST000		NO:	CUGCUUUAGGAAUCAGUAAC
00433977-		500
90
ENSG000	1.274652444	SEQ	AGUCGGUGAAGGGCGAGCGGCGCGGCGGCUGCG
00136404-		ID
ENST000		NO:
00379384-		501
33
ENSG000	1.497033428	SEQ	CUCUUCCUGAGAAACGAGCAAACCUGAAAGCUACUC
00136514-		ID	UCUCAGCUUCAGAGGGAAAAA
ENST000		NO:
00259030-		502
57
ENSG000	1.420321563	SEQ	AUUUACUCCAUCCUUUAUAGUGAGUCUACAGGACG
00136560-		ID	AAGAGGA
ENST000		NO:
00403609-		503
42
ENSG000	1.600646987	SEQ	AUCACUGACCUUGGAAGCUGCUGGAGCCACGAUUC
00136688-		ID	AGUCCCCUGGACUGUAGAUAAAGACCCUUUCUUGCC
ENST000		NO:	AGGUGCUGAGACAACCACACU
00259205-		504
92
ENSG000	1.123375448	SEQ	ACCAACGCUGUCGCCACCUCUGUAGCC
00136861-		ID
ENST000		NO:
00473282-		505
27
ENSG000	1.120416332	SEQ	ACUGCUUUCUUGGGAAG
00136930-		ID
ENST000		NO:
00259457-		506
17
ENSG000	1.440814772	SEQ	AGACAGUUCCUGCAGCGCUUACCGCCUGGCCUCUCG
00136937-		ID	GUUCCGCGGCGCACCGGAGGGCAGC
ENST000		NO:
00375147-		507
61
ENSG000	1.188196376	SEQ	ACACGCUGCAAAAGGCUUUCCAAGAAUCCUCGAC
00136960-		ID
ENST000		NO:
00520066-		508
34
ENSG000	1.221018744	SEQ	ACAGAAUACUGAAAA
00137033-		ID
ENST000		NO:
00611532-		509
15
ENSG000	1.409150199	SEQ	ACAGAGCUGCAGCUCUUCAGGGAAGAAAUCAAAAC
00137033-		ID	AAGAUCACAAGAAUACUGAAAA
ENST000		NO:
00682010-		510
57
ENSG000	1.213289572	SEQ	CGCCUCUUCUCUUUUUGGGAACGUGGCGAGCAAAA
00137074-		ID	AAGUCUUGAGCCAGAGUG
ENST000		NO:
00467331-		511
53
ENSG000	1.375070072	SEQ	UUCAAGGUUACCCAUCUCAAGUAGCCUAGCAAUAU
00137080-		ID	UGGCAACAUCCCA
ENST000		NO:
00380225-		512
48
ENSG000	1.149603089	SEQ	AGUGUCGAUCCCUCAGCCAGGGC
00137135-		ID
ENST000		NO:
00475323-		513
23
ENSG000	1.31471218	SEQ	CCGGGCGAGCGCAGCCAAC
00137177-		ID
ENST000		NO:
00378826-		514
19
ENSG000	1.37316859	SEQ	AUUGAGAUCACAUAGCCAACUCUG
00137204-		ID
ENST000		NO:
00436107-		515
24
ENSG000	2.196827289	SEQ	AUUACACAUUCAAAGUAUCCAUUUGUUCUCAAGAG
00137397-		ID	GUAGCAAGAAACAGUAUCCACAGUGGACUCCGGGG
ENST000		NO:	CUCCUACAGACUUGGCACAGCUUCCUACAGUCUUGA
00357569-		516	AACAGCCCUGUUGUUCUGUC
126
ENSG000	1.220664428	SEQ	AUUUCUCGCC
00137404-		ID
ENST000		NO:
00376421-		517
10
ENSG000	1.286952453	SEQ	ACACUACGCCAGAACAAG
00137413-		ID
ENST000		NO:
00372977-		518
18
ENSG000	1.30072718	SEQ	AACGAAGAGGCACACAGGAGGUCGGAGAACACAAU
00137491-		ID	AUCAACAGGGCCAGCGGGUGAGGUACCCCAGGUACC
ENST000		NO:	AGACAAGGAAACCAAAGCCACA
00530556-		519
93
ENSG000	1.874881202	SEQ	AGAAGAGGACGUUGUCACAGAUAAAGAGCCAGGCU
00137496-		ID	CACCAGCUCCUGACGCAGUCAUC
ENST000		NO:
00393707-		520
58
ENSG000	1.250896159	SEQ	GUGAUCAGCUC
00137642-		ID
ENST000		NO:
00534286-		521
11
ENSG000	2.329684846	SEQ	AUUAUUUUCUAAAUUCUGUGCUAACAGAACCGGCU
00137675-		ID	UCAGCUGAAGAAAGAGAGGA
ENST000		NO:
00260229-		522
55
ENSG000	1.524938971	SEQ	AUACUUUCAGUUUCAGUCACACAAGAAGGGAGGAG
00137752-		ID	AGAAAAGCC
ENST000		NO:
00353247-		523
44
ENSG000	1.096978726	SEQ	CAGUAAAUAAAAACACAACUAUUGAUUCAGAGAAA
00137871-		ID	GGAAAAUUGAUC
ENST000		NO:
00558067-		524
47
ENSG000	1.349626178	SEQ	CCUUUCCCUGUUAGAC
00137955-		ID
ENST000		NO:
00319942-		525
16
ENSG000	1.443191362	SEQ	AACAGUUAAUCCUCAAUUUAAGCCUGAUCUAACCCC
00137959-		ID	UAGAAACAGUAUAGGAUAUAUUCUGUUAAAGAGUG
ENST000		NO:	AAAAAAGUGAAAAUCUCUGCCAUUU
00680295-		526
96
ENSG000	1.522146348	SEQ	ACUCAGAGGCCGUCCAAGACACUGGCAAGCCGCAGA
00138039-		ID	AGCCCAGUUCGCCGGCC
ENST000		NO:
00294954-		527
53
ENSG000	1.197719658	SEQ	ACAGAGCAGGUUCUUUUACAGGGAGCCACC
00138068-		ID
ENST000		NO:
00535679-		528
30
ENSG000	1.181668687	SEQ	GUCACCUCUGACAAAAUUCUGGGGACGCUGGGAAC
00138162-		ID	ACUGAAUCAAC
ENST000		NO:
00334433-		529
46
ENSG000	1.342668752	SEQ	AUUGUUUGAAUUUGAAAACGGUAACAUCGCAGUGC
00138182-		ID	UGCUCGCGGGUCUGGCUAGUCAGGCGAAGUUUGCA
ENST000		NO:	GA
00260753-		530
72
ENSG000	1.291351298	SEQ	GCAGGAGUCUACACCCAGGCGGUGGCUAUACUUAU
00138231-		ID	UAAAGUUGGCGGGAGCUGAGCGAUCAGUCGGUCCU
ENST000		NO:	GGGCUGGCUGUGGUGUAGGGCGUUGCAGGCAGCGC
00260803-		531	UCACCUCCUCAGGCCGGCAGA
126
ENSG000	1.680490531	SEQ	GCAUUUAUAUAGCAGAGUAAGAAUCAGGAAAGAAG
00138592-		ID	CACUUGUAAGGAAAUAUAGCAUCCAUUGUGAAAGU
ENST000		NO:	GGAAAAGUAAAGAUAAUUCAUC
00558091-		532
92
ENSG000	1.599779967	SEQ	CUCAGUCAAGCUGAAGUGAAAACGAGACCAAGGUC
00138684-		ID	UAGCUCUACUGUUGGUACUU
ENST000		NO:
00648588-		533
55
ENSG000	1.392715227	SEQ	GAAAUCUUUUAGGCCUUUAGAGUUUGUUCUGGAAA
00138688-		ID	AACUUUAGUA
ENST000		NO:
00388738-		534
45
ENSG000	1.354008715	SEQ	ACAUUGACUGCUCUGCUGCUGCA
00138696-		ID
ENST000		NO:
00440890-		535
23
ENSG000	1.271036129	SEQ	GGGCCCUGACAGUUGAAAGGAAGGAAGUUGCCCUA
00138741-		ID	AUAUUCUACAGUUGUUUUAUCGUUGCUACUGAUUA
ENST000		NO:	GGUCC
00506449-		536
75
ENSG000	1.408945716	SEQ	AAAGAAUUUCUCAGGCUCAAAAUCCAAUACAGGAG
00138755-		ID	UGACUUGGAACUCCAUUCUAUCACU
ENST000		NO:
00264888-		537
60
ENSG000	1.413788622	SEQ	AUUGUGGGAAAAG
00139180-		ID
ENST000		NO:
00266544-		538
13
ENSG000	1.222487091	SEQ	AAGUCUGUUCAGCUGCCUGUUUGAAGAAAGUUUAU
00139220-		ID	UUUUUAAAAACUAGUUUUGCAGUUGGCUGAAGAGA
ENST000		NO:	GACAGUGAAAUAUUGAAGAACGU
00551461-		539
93
ENSG000	1.311768333	SEQ	ACUUCCGGGCUCGGCAGCUAGACUAGCGGGGGCAGC
00139631-		ID	CUCAGAGCGGCUACCUGUGCACCCUGCCUCCGGCUC
ENST000		NO:	UCCUGAGCAGAGAGAUCCUG
00437073-		540
92
ENSG000	1.144898413	SEQ	UAGGGCCGCUGUGG
00139746-		ID
ENST000		NO:
00267229-		541
14
ENSG000	1.140503021	SEQ	GUCUUGGAGAGAGGCUGUGUGCAUUAGCUACAAAU
00140262-		ID	AGUAACAUUUUCAAAAUCAAC
ENST000		NO:
00343827-		542
56
ENSG000	1.699983351	SEQ	ACUGAAGACUUACUCCCUUUGCCUGUGUGGAUAUA
00140262-		ID	GUUCUUGGAGAGAGGCUGUGUGCAUUAGCUACAAA
ENST000		NO:	UAGUAACAUUUUCAAAAUCAAC
00543579-		543
92
ENSG000	1.390016553	SEQ	GAGUCAUACUCCAGUGGUUUAGUUGAUAAAGUAUC
00140386-		ID	UUGGCAUAGAAGAGAAUUUAAAGA
ENST000		NO:
00324767-		544
59
ENSG000	1.159919678	SEQ	AGUCUCCUUUAAGGAGAGCUUGUAGGCUUCUAAUU
00140403-		ID	UCACAUUUCAGCAAGCUGGCUAAAGAC
ENST000		NO:
00446172-		545
62
ENSG000	1.237967637	SEQ	CCGCUGAAGUGGAGCAGGUACAGUCACAGCUGUGG
00140459-		ID	GGACAGC
ENST000		NO:
00435365-		546
42
ENSG000	1.223971881	SEQ	GUGAGGCCGAGGUGACUGCAGAGCGGCUCGCGAGU
00140525-		ID	UCUGUGAUAGUAGCAACA
ENST000		NO:
00563250-		547
53
ENSG000	1.113367469	SEQ	UCCACGUUUCUUUAGCGGGCAGUGGUAAAAAGAGU
00140718-		ID	AUUUAAGAUCGGUCGAGUUUGAGUGGCUGAGGCAG
ENST000		NO:	UUUUGGUUUCAAGGCAAUCGAUACAGAAAGUGCAC
00460382-		548	UGACUGGUGGUGUCAACCC
124
ENSG000	1.379159616	SEQ	GUGGUUUCCUAGAAACAGUAUUGUUUAUUGGCAUU
00141027-		ID	GAUCUCACAGUCUGGUGAGGACUUCUUUACUGAUA
ENST000		NO:
00395848-		549
70
ENSG000	1.134255567	SEQ	GCCUAAAGUAAAAUUCAGCUCGAAGUACAGCAGUA
00141255-		ID	UAAAGACAG
ENST000		NO:
00574051-		550
44
ENSG000	1.329912052	SEQ	CAAUAAAGUUUUAUAUUUAUUUUGUGAAGGUGCC
00141279-		ID
ENST000		NO:
00530514-		551
34
ENSG000	1.796554333	SEQ	ACUUGCCGAUAGUGGUGACGGCGGCAAC
00141380-		ID
ENST000		NO:
00582792-		552
28
ENSG000	1.230257795	SEQ	AGCGAUAUCCGGACACAGAUCACAGCGUUCUUUCU
00141404-		ID	GUUUGUUUGCAGGGGCUGGUGAGUCUGGGAAAAGC
ENST000		NO:	ACUAUCGUCAAACAG
00585642-		553
85
ENSG000	1.191594015	SEQ	UCAGAACCAUCAAGUAGAGUCAAAC
00141431-		ID
ENST000		NO:
00592288-		554
25
ENSG000	1.398730258	SEQ	CAACCCUGAAGUUCAUAGUUAGCUACUUUCAACUG
00141434-		ID	GAAGCUACAAC
ENST000		NO:
00581447-		555
46
ENSG000	1.513906113	SEQ	ACUCGCCUCAUUUUCUCUAAGCAGAGCAACUUCGCG
00141668-		ID	GACAGCGGAGCUCGCCCAGCAGUG
ENST000		NO:
00584764-		556
60
ENSG000	1.212522073	SEQ	ACUGGGCGGACCGCGGCGGCAGC
00141744-		ID
ENST000		NO:
00269582-		557
23
ENSG000	1.259900848	SEQ	ACUUUCACUCACCGCCUGUCCUUCCUGACACCUCAC
00142484-		ID	C
ENST000		NO:
00270560-		558
37
ENSG000	1.395323206	SEQ	GUGACAGAGCGCUUUACGACAGUUGCUUUGAGGCA
00142507-		ID	GUACCGGAGGAGAAAG
ENST000		NO:
00614486-		559
51
ENSG000	1.24945238	SEQ	CUGGGAGUCGUUAGUGAGG
00142546-		ID
ENST000		NO:
00594932-		560
19
ENSG000	1.254143024	SEQ	ACAUUUGCGGGAACGCAGAGCGGAGCGUGGAGAGC
00142552-		ID	GGAGCGAAGCUGGAUAACAGGGGACCG
ENST000		NO:
00270645-		561
62
ENSG000	1.128512499	SEQ	AGUGUGUGGCUGCUUCUGGACUCAAGGAGGAGGAG
00142611-		ID	AGAGAUUCCGCGAGCCGACACC
ENST000		NO:
00270722-		562
57
ENSG000	1.379157796	SEQ	CUCUUCCUGCUCUCCAUC
00142676-		ID
ENST000		NO:
00643754-		563
18
ENSG000	1.359498231	SEQ	AGUCCUUGGCGUUUCCUUUGGCGGAUUUUCUGUUU
00142856-		ID	UCGGAAGUUGCUGGGUUCGUUUUAUUCAGCGGCAG
ENST000		NO:	UGGUGCUUUCCCGAAUCUCAGA
00271002-		564
92
ENSG000	1.688343768	SEQ	GUUUUCGGAAGUUGCUGGGUUCGUUUUAUUCAGCG
00142856-		ID	GCAGUGGUGCUUUCCCGAAUCUCAGA
ENST000		NO:
00371092-		565
61
ENSG000	1.357553822	SEQ	ACAGUCAUAGCUCUUAGCUUCUGUGUAAGAAGUUG
00142875-		ID	UGAGCUCCUUCUGGAAACAUUUGCAGUUACAUUAA
ENST000		NO:	GUAAAGUGUAAAGUCACAGUA
00370685-		566
91
ENSG000	1.148814753	SEQ	GUUAUUUUGAGCAAUAGUUUUUGGAAAGGUUGGUU
00142875-		ID	UUCAUC
ENST000		NO:
00394839-		567
41
ENSG000	1.130408224	SEQ	ACGAGCCUUUCCGGUGCU
00143183-		ID
ENST000		NO:
00612311-		568
18
ENSG000	1.229689439	SEQ	CUCUUGCGCCCUGGUCCAAG
00143222-		ID
ENST000		NO:
00368003-		569
20
ENSG000	1.144374529	SEQ	ACAGUGCUGGG
00143226-		ID
ENST000		NO:
00271450-		570
11
ENSG000	1.15445736	SEQ	AGAAGUGUCUGACAAAACAAAGAAACAAAACCUCA
00143248-		ID	GUGAAAA
ENST000		NO:
00367903-		571
42
ENSG000	1.628278755	SEQ	CAAAGACUGGCUCUGCUGUUAAGAAGUUGUACUUA
00143248-		ID	AAGCGGAGGAGCUAAGCCACCUGCCAAA
ENST000		NO:
00531476-		572
63
ENSG000	1.22937685	SEQ	AGAAUUGUUAAAAUCUUUGUGAAGCACACCACUGA
00143278-		ID	AG
ENST000		NO:
00367412-		573
37
ENSG000	1.233402722	SEQ	AGAACUGAGCUCAUCUUUGCGGGGUUAGCUAGCCG
00143321-		ID	UUGAGUCCAAGUCUCCUUGGCAAGACAGUAGCUUA
ENST000		NO:	GAGAAACGAGAUCGA
00368206-		574
85
ENSG000	1.180621821	SEQ	CUCUUUACACAGAACAGUUUAACUUUUGUGCUUCU
00143322-		ID	GGGCAGAGGU
ENST000		NO:
00344730-		575
45
ENSG000	1.242198062	SEQ	CUGGGCAGAGGU
00143322-		ID
ENST000		NO:
00512653-		576
12
ENSG000	1.485125549	SEQ	AAAAAGAGCCCUUGAAGCUGGAAGACGGGAGAGGA
00143379-		ID	CAAAAGC
ENST000		NO:
00368964-		577
42
ENSG000	1.66529389	SEQ	AAGAGAGAAUCUCUUAUAGUUGCUGAUACAGGUUU
00143398-		ID	CAACUUUCUGUGCUGUGGGGUCAGUGGUAAGAGAG
ENST000		NO:	CAGCAUCUGGAAUCAAGAGACCC
00418435-		578
93
ENSG000	1.11234934	SEQ	AUUCUGUGCCUGUGAAC
00143436-		ID
ENST000		NO:
00368830-		579
17
ENSG000	1.134078117	SEQ	AUUUUCGAGUUGGUGAGACACCGCGGCAGUCGACU
00143507-		ID	UGGAAGAGUCUCUGGUGGUAGAGGUGGACUUAGUA
ENST000		NO:	GUUUUAAGCAGAACC
00468085-		580
85
ENSG000	1.192767603	SEQ	GUGAGAGGAGGCUGCAACGCCGAGCGGAGGAGGCA
00143549-		ID	GGAACCGGAGCGCGAGCAGUAGCUGGGUGGGCACC
ENST000		NO:
00368533-		581
70
ENSG000	1.667823427	SEQ	ACACAUCUCACUCAUCCUUCUACUCGUGACGCUUCC
00143556-		ID	CAGCUCUGGCUUUUUGAAAGCAAAG
ENST000		NO:
00368723-		582
61
ENSG000	1.175624102	SEQ	GUCAGUGUGGAGGAGACUGAGUAUUCUACCUUGUA
00143569-		ID	AAUACUGUUAUUUGUAUAUACUGUAA
ENST000		NO:
00428931-		583
61
ENSG000	1.413605476	SEQ	GGAAGGAAGUGUUUUUAAAACUACGUGAGGCAUCA
00143977-		ID	GAAUCCGAAAGCCACUUUAGUCUUAGCAA
ENST000		NO:
00413456-		584
64
ENSG000	1.267636273	SEQ	GCCUCCAGGAUC
00144115		ID
ENST000		NO:
00324166-		585
12
ENSG000	1.142958067	SEQ	CCUCACACCAACAACUGCACCUACUUUCUUACAGGG
00144130-		ID	UUGGAGUCCUAUAAC
ENST000		NO:
00327581-		586
51
ENSG000	1.201604128	SEQ	GUGUAAGACACUGAAGACACUGCAGAGCAAGGUGC
00144290-		ID	UUAUUCCAGAGGCGUUACAAAAC
ENST000		NO:
00421911-		587
58
ENSG000	1.100129357	SEQ	UAGACUAUAAGCUUUUGGAAAACAGGGACUAGUUC
00144331-		ID	UUCUUCAACAAGUUGUACACAACAAGUAGCAGGUU
ENST000		NO:	GUUUGGCACAGUGCAG
00439340-		588
86
ENSG000	1.107466439	SEQ	ACAGUCUUGAGUCAUUCAUUCUCAAGGACACUUGA
00144410-		ID	UCCACUGCCAGAGAGGCCCAGAAUUUUCUAACUUAC
ENST000		NO:	UGUGUGGCAGA
00272852-		589
82
ENSG000	1.145354517	SEQ	AGUAGCGGGCGGCAGAGCUGGAGUGAAGGGAGCUA
00144591-		ID	GUGGUAGCAGUCACCAUU
ENST000		NO:
00682481-		590
53
ENSG000	1.422725123	SEQ	UCUUUCCGGGACAAC
00144895-		ID
ENST000		NO:
00482093-		591
15
ENSG000	1.371132109	SEQ	AGAGAAGAAG
00145191-		ID
ENST000		NO:
00648682-		592
10
ENSG000	1.273612863	SEQ	ACCACUUUUACAGUGUCACCUACAGGAGAGAGGAG
00145321-		ID	GUGCUGCAAGACUCUCUGGUAGAAAA
ENST000		NO:
00273951-		593
61
ENSG000	1.234149722	SEQ	ACUGUUUUUUCAAAGAGAUUGCUUACUCCACCAGG
00145321-		ID	AGAAGUAUAUCUACCUAUUCUACCACUGGUGAGUA
ENST000		NO:	UCUGGACUAGUCCAACUGGUAGGAA
00504199-		594
95
ENSG000	1.510041506	SEQ	GUACAGGCGGCACGGUUUGAGUGCAGAGAUAUUUU
00145362-		ID	CUUUCCAAACUGUUCAAA
ENST000		NO:
00394537-		595
53
ENSG000	1.86606588	SEQ	GGUUUAAUUCUUCAGAUCACAUUGAGAGUAAAGGU
00145414-		ID	AUUAAAAUAAAGGAGACU
ENST000		NO:
00509434-		596
53
ENSG000	1.184037397	SEQ	UAUUUUCAGAAUUUCAGAAAUUGAAAAGGGAUAAG
00145416-		ID	AGGAAGGAGAAA
ENST000		NO:
00274056-		597
47
ENSG000	1.164271099	SEQ	CUAUAUUCUCUGUUCUGCAUUAUAAGCAAC
00145416-		ID
ENST000		NO:
00339875-		598
30
ENSG000	1.506110818	SEQ	ACAAGCGCCUUACGAAAGGCGGCAAAAAGGGAGCC
00145425-		ID	AAGAAGAAAGGUUGAUCCAUUUUCUAAGAAAGAUU
ENST000		NO:	GGUAGUAGUUGAAAGCACCUGCU
00507327-		599
93
ENSG000	1.169807393	SEQ	CUCUUCCGGUCUUUCUGGUCUCGGCCGCAGAAGCGA
00145592-		ID	G
ENST000		NO:
00274242-		600
37
ENSG000	1.654899794	SEQ	UAUAGGUUUUAAAAGUAAUUCCAAGACACCAUUAC
00145675-		ID	AAAGAAAGCCGGACUCUUUUCUUAUAACUGAGCUC
ENST000		NO:	AGCCAAGGAAACUCUUGCACAA
00336483-		601
92
ENSG000	1.228077774	SEQ	AGCAGCUUGUAUUCUUAGAAACGCAGCAGACAGCA
00145703-		ID	ACUUUAGCAGGUGAUUUCAAUCAAGUCAGCUGAA
ENST000		NO:
00396234-		602
69
ENSG000	1.249023976	SEQ	ACGAGAGGAAGCUUAAAUCUGUCGUUUGAAUUUAG
00145723-		ID	GACCACCUCGGUUCACA
ENST000		NO:
00512248-		603
52
ENSG000	1.298039977	SEQ	AGUGUCGAGUCAGCUGUAGUGACAAUCUCAGAGCA
00145879-		ID	GCUUCUACACCACAGCCAUUUCCAGC
ENST000		NO:
00274565-		604
61
ENSG000	1.268497747	SEQ	CUUUUCUGAAAACAUCAGCAUUCUGCCAUAUCUGG
00145934-		ID	AAUA
ENST000		NO:
00518659-		605
39
ENSG000	1.189230872	SEQ	ACUUCGCUGUGAAG
00146007-		ID
ENST000		NO:
00274712-		606
14
ENSG000	1.272249185	SEQ	UAGUAGUAGGCUCCCUUCCCACCUCAGUCAUUGGUU
00146147-		ID	UGCUCGCUCCCUUAGUUGAGUAAUCA
ENST000		NO:
00503951-		607
62
ENSG000	1.327706632	SEQ	UCUUUCUCUCUUUCUCAUUCUCUUUCAAU
00146147-		ID
ENST000		NO:
00509997-		608
29
ENSG000	1.358539776	SEQ	GGAAACUUAUUUAAGGAGUGCUGACUUACCGUAUC
00146267-		ID	AGGUGAUAAGAAGUACAUC
ENST000		NO:
00538471-		609
54
ENSG000	1.734820535	SEQ	UUUUAGUGGUGGAGUCAAUUUAUUUCUGAAACGAU
00146592-		ID	CUCAUUUACCUGAAGUAGGAGCUCAUAUUUAUUUU
ENST000		NO:	CAGGAUUUAGUAGGAAUCCAAG
00396300-		610
92
ENSG000	1.10489515	SEQ	ACUCAAGUUCGGAACGUUCCGAAG
00146776-		ID
ENST000		NO:
00318724-		611
24
ENSG000	1.899199977	SEQ	GAUCGCUUCAGGUUCCAAAAGUACAACAGUUUUAC
00146776-		ID	AGUCGUCGUAGCAUCAGAUUAAGUUGGCAGCCUGA
ENST000		NO:	GUCUCUCUAGAGAAGACACGGUUCA
00472195-		612
95
ENSG000	1.74032445	SEQ	GUAGAUUAGCUCAACACUCGAGAAUCAUUGCAGCU
00146809-		ID	UCAAGGA
ENST000		NO:
00275699-		613
42
ENSG000	1.121553935	SEQ	GAGCACGGAACUUAUUCCUGCCCAGAGUUCAGACAC
00147010-		ID	AGCCAGAAAUUACCAUUUCAUACUUCACAGA
ENST000		NO:
00379698-		614
67
ENSG000	1.219039436	SEQ	AAAAUUAGAAAAUUUAAACUUCUUCAGUAGGACGU
00147044-		ID	GUUGGAACACCUCAUUUU
ENST000		NO:
00643043-		615
53
ENSG000	1.170463811	SEQ	GCGGCCGAUCAGAGGAGCAGGAACUGGAACCCUGG
00147099-		ID	CCGAGUCCGAAAAAAGCCAGAUCUGGAAGGUGGCU
ENST000		NO:	GCGGAACGGUUUUAAGCGGAAG
00373554-		616
92
ENSG000	1.643128391	SEQ	CCGAGUCCGAAAAAAGCCAGAUCUGGAAGGUGGCU
00147099-		ID	GCGGAACGGUUUUAAGCGGAAG
ENST000		NO:
00648834-		617
57
ENSG000	1.20698	SEQ	GCAGCUGAGCGUUGGAAGCCAUUUUGGCUGCAACC
00147127-		ID	UACCUGAAGCG
ENST000		NO:
00276066-		618
46
ENSG000	1.248024213	SEQ	AUUCGGCAGCCAGACUCCUUGAAAUACCCUUUCAGU
00147166-		ID	AAUCAUUCAACCAACGCUUCC
ENST000		NO:
00373829-		619
57
ENSG000	1.4528557	SEQ	ACAGUACUCAACCUACUUCAAGGGAAGAUUGGGAU
00147437-		ID	CUUUUUGGCUCUCUGCCUCUAAACAGA
ENST000		NO:
00421054-		620
62
ENSG000	1.954172457	SEQ	AAGAGGACUCCAAGCGCC
00147576-		ID
ENST000		NO:
00276576-		621
18
ENSG000	1.494732017	SEQ	ACUCCAAGCGCC
00147576-		ID
ENST000		NO
00422166-		622
12
ENSG000	1.112748848	SEQ	CCUCUUUUUCCGGCUGGAACC
00147604-		ID
ENST000		NO:
00352983-		623
21
ENSG000	1.257158970	SEQ	UCUUUCUUCCUGUCUGCUUGGAAAG
00147677-		ID
ENST000		NO:
00518995-		624
25
ENSG000	1.272203789	SEQ	AAGAGACGCUUCCUUCUGAUC
00147862-		ID
ENST000		NO:
00636735-		625
21
ENSG000	1.158431422	SEQ	ACCUCUGGUGCCAAAGGGCGGCGCAGCGGCUGCCGA
00147889-		ID	GCUCGGCCCUGGAGGCGGCGAGAAC
ENST000		NO:
00579755-		626
61
ENSG000	1.322161708	SEQ	CGGCGUGUUGGUCCCAGCGGUUCAGCUGAGGUAGG
00147996-		ID	GACGUGCCGUAGGCCGGA
ENST000		NO:
00430059-		627
53
ENSG000	1.575979209	SEQ	GUCUUAUUCUUUUUAGUGGAGUUUUCCAAGGAUUG
00148187-		ID	UCUUCAGUC
ENST000		NO:
00489572-		628
44
ENSG000	1.265236768	SEQ	CAGUGCUGCAAUAGAACUUUUCAGCAGACUACAAG
00148200-		ID	AAGCAGUAA
ENST000		NO:
00475178-		629
44
ENSG000	1.284654826	SEQ	GUCUGCCGGGCC
00148803-		ID
ENST000		NO:
00278025-		630
12
ENSG000	1.27621693	SEQ	CAUUAUAAGUUCAGUAGUACAACAUUUUGUGAGAG
00148935-		ID	AAGUCUGUAUAAAAAGCAAUUGCUCUUUUGUUUCC
ENST000		NO:	AAAACAGGUAUUACAAGUGGAUAAAUA
00532398-		631
97
ENSG000	1.604750689	SEQ	AUUCACUCGCUCUUUUCAUUCACGAAGGUAGUGAG
00149084-		ID	GCCUAGUGGAAAGCC
ENST000		NO:
00636007-		632
50
ENSG000	1.133062745	SEQ	AUUCACGAAGGUAGUGAGGCCUAGUGGAAAGCC
00149084-		ID
ENST000		NO:
00636722-		633
33
ENSG000	1.383974628	SEQ	AUUCCGUGUUC
00149084-		ID
ENST000		NO:
00638034-		634
11
ENSG000	2.328080788	SEQ	AAGCUGAGAGGGCCCGCGGGUAGGC
00149262-		ID
ENST000		NO:
00534064-		635
25
ENSG000	1.108821914	SEQ	UUAGGGAUUCCGGUUCACA
00149292-		ID
ENST000		NO:
00314756-		636
19
ENSG000	1.268076996	SEQ	GGAAAGUCACAAGCCUCUUGAGUCAUAAAAACAGC
00149300-		ID	UGGGCUCCCUUGGAGACAGAGCGCC
ENST000		NO:
00278601-		637
60
ENSG000	1.465679578	SEQ	GCAUUCCCUUGGGCAGAGAGUGGAG
00149489-		ID
ENST000		NO:
00278833-		638
25
ENSG000	1.352591675	SEQ	UGGCAUCUUCCUUACUUUGUCCAUCCUCCGGACUCG
00149532-		ID	CGAUCUUCCUUCCGGAGCC
ENST000		NO:
00536145-		639
55
ENSG000	1.209434894	SEQ	ACAAGGAGGCAGGCAAGACAGCAAGGCAUAGAGAC
00149968-		ID	AACAUAGAGCUAAGUAAAGCCAGUGGAA
ENST000		NO:
00299855-		640
63
ENSG000	1.183808331	SEQ	AAGGAGGCAGGCAAGACAGCAAGGCAUAGAGACAA
00149968-		ID	CAUAGAGCUAAGUAAAGCCAGUGGAA
ENST000		NO:
00524478-		641
61
ENSG000	1.751805475	SEQ	AUUUCAGUUUAUACUUAAUAAAACAAAACAUACCU
00150045-		ID	GUAUACACACACAUUCACUCACAUUGAAG
ENST000		NO:
00279545-		642
64
ENSG000	1.529361133	SEQ	AAGUAAAAGUGGUCAAACAACUUAACAGUGUGCCA
00150093-		ID	GUUUUCCUAAGCGUGCUUGCCACUGAUUGUAAGUC
ENST000		NO:	UUUUAUUGUUUGGCUUCUUGAUAA
00480226-		643
94
ENSG000	1.367487177	SEQ	CUUUCUCAGAAAACCAAAU
00150540-		ID
ENST000		NO:
00280096-		644
19
ENSG000	1.341507935	SEQ	UGUCUUUAAAAAAUAACUGUAUACUAAGCAAAACU
00150636-		ID	CAGGUCUUAAAAAUAAAU
ENST000		NO:
00581520-		645
53
ENSG000	1.133266124	SEQ	GGAGUGUGUCUGAGGAAACACAUCCCGGACACCAC
00150722-		ID	UUAGGGUUAGUCUUUCUGAGCUCUUCACAUCUCUG
ENST000		NO:	ACUAAUUAUCAUCAUUACC
00409702-		646
89
ENSG000	1.349622591	SEQ	UUCCUACGACAAAAGAUACAUCAUCAAGACUAUUA
00150867-		ID	CCAGUGAAGACGUGGCCGAA
ENST000		NO:
00323883-		647
55
ENSG000	1.281733641	SEQ	CUUCCCUGGCCUUGCCCUCUCUCUUUCUGCCCUGUA
00151062-		ID	GCCGCGGGCGUCCAA
ENST000		NO:
00538027-		648
51
ENSG000	1.343539722	SEQ	GUCUGACGGCACUUAAGGUCUAAAAAAGAAGGAAG
00151093-		ID	UUGUUUCUGAUCAUCUGAAUCUUAAUC
ENST000		NO:
00428266-		649
62
ENSG000	1.141568488	SEQ	CUGUGGUUUAAGGGACUGUGCUCGGGGAAGACGUG
00151474-		ID	CUGUCAGCG
ENST000		NO:
00649155-		650
44
ENSG000	1.565400149	SEQ	AGCUGGGGAGUUUGCAGAUCUGAUCUGUCAGCGGG
00151474-		ID	GACUGAGAGCAAAUCGGGACAUUCAUC
ENST000		NO:
00649947-		651
62
ENSG000	1.297593807	SEQ	UCACAAUCACAUUGAGCCAAAACGCAUCCAGUGUU
00151611-		ID	UUCUCCAGUUACAAAUAAAACGAAU
ENST000		NO:
00647947-		652
60
ENSG000	1.490938996	SEQ	GAUAAUCUUUUCCUUCUUAUUCAUUGCAGAAGCUU
00151687-		ID	CAAAAAGGACACACUAGAUUUAAUUAGAA
ENST000		NO:
00313581-		653
64
ENSG000	1.392974894	SEQ	AGUAUCCCGAUAUUUUAAAAGCUGAGAUCUCCACU
00151718-		ID	ACAAGAUUAAGGU
ENST000		NO:
00504005-		654
48
ENSG000	1.243892669	SEQ	ACGCGCUCUACUCCUGUAACGGAAAGGUCGCGGCUU
00151846-		ID	GUGUGCCUGCGGGCAGCCGUGCCGAGA
ENST000		NO:
00281589-		655
63
ENSG000	1.655756045	SEQ	UUAUACUUCAGUUGUUCAGUCAGAUUGGACCCUGU
00151923-		ID	AAAAGCUGUAAA
ENST000		NO:
00369086-		656
47
ENSG000	1.18852873	SEQ	GCACAUUUGGCUAUUUUUCAAAGAGAGCAGUUAGU
00152061-		ID	UCAAGAAAGUGCUUAUUUUGUUUUUUAUUCUUCUU
ENST000		NO:	UUUGUGGUCUAUUUAGGAAAACAAA
00347255-		657
95
ENSG000	1.316014396	SEQ	AGUCUGGUCUGGAGCUGGGACAGCAGCUGCUGCUG
00152061		ID	UGGAAAGGCCAGCUGGCAAG
ENST000		NO:
00392064-		658
55
ENSG000	1.553255941	SEQ	ACCUUUCCGCGGGCCGCGGGG
00152082-		ID
ENST000		NO:
00281871-		659
21
ENSG000	1.214248325	SEQ	AAAAAUCUCAGU
00152234-		ID
ENST000		NO:
00585650-		660
12
ENSG000	2.480118118	SEQ	AGCCGCAGCU
00152240-		ID
ENST000		NO:
00585518-		661
10
ENSG000	1.460980997	SEQ	GCAGUCCAAUUCAUCAGUUGUCUUUAGUUUACUCA
00152266-		ID	GCAUCAGCUACUAACAUACCUGAACGAAGAUCUUG
ENST000		NO:	UUCUAAGACAUUGUAGUUGAAG
00282091-		662
92
ENSG000	1.418126325	SEQ	AGACUUGGUAUAGUGGGAGAGCCUGACUGAGAGUG
00152556-		ID	GAUC
ENST000		NO:
00312352-		663
39
ENSG000	1.56883394	SEQ	AUCUUGAUUCCUGCUGUGUCUUAACUGACCAUUGU
00152556-		ID	CUUAAAUUCUAGAGUGGAUC
ENST000		NO:
00546465-		664
55
ENSG000	1.495932291	SEQ	AGAAUAAACAUUUCUGGGA
00152670-		ID
ENST000		NO:
00511853-		665
19
ENSG000	1.267655147	SEQ	GUGAAGUAGAGUGAGCAUUAGCCUGGCAGACAGCU
00152818-		ID	AGGGUAAUAGAGUACUUCCAGUGGAAGUCAAAGCA
ENST000		NO:	CAA
00455022-		666
73
ENSG000	2.319422253	SEQ	GUGAAUUAUAGUUUAAGUUACUGCAAGUCCUAAAC
00152942-		ID	UACGGAGUGGAACUAUUACAGUUUAUA
ENST000		NO:
00380774-		667
62
ENSG000	1.241287767	SEQ	CAGGAGUUCCUCCUUGGCCGCGGCUGUAGCUGAGA
00153048-		ID	GAAGGGACAGGAGGUCAGCC
ENST000		NO:
00567554-		668
55
ENSG000	1.347315863	SEQ	ACUUCCGGUUAAGAAGUCAACACUCAGGUCUGAAA
00153130-		ID	AUUGAACAAG
ENST000		NO:
00338517-		669
45
ENSG000	1.348682671	SEQ	ACCUUUAAUUUCCUCGAAAACGCCUGUAACUCGGCU
00153234-		ID	GAAGCC
ENST000		NO:
00409108-		670
42
ENSG000	1.120345783	SEQ	UUACGACACUGUCCACCUUUAAUUUCCUCGAAAACG
00153234-		ID	CCUGUAACUCGGCUGAAGCUUCAGUACCUUU
ENST000		NO:
00429376-		671
67
ENSG000	1.525738722	SEQ	AUUUGCCUUCUCUUCACUUGGGGAGUAUCAAUUUG
00153250-		ID	CCACAGCAGUCUCUGGUCCCAGCCCACCCC
ENST000		NO:
00409289-		672
65
ENSG000	1.413535488	SEQ	UAAGGUAAUUCGUAGUCAAGAAGCUACACGUAAUU
00153253-		ID	AAAGUUGCAGGAGUAAAAG
ENST000		NO:
00440431-		673
54
ENSG000	1.184687091	SEQ	AAUUGACUUUGUGAUCAUUACAGAAAGUCUGGUGU
00153283-		ID	AAGGUGUUCAGAAGACA
ENST000		NO:
00283285-		674
52
ENSG000	1.429514237	SEQ	CAUCAAUUGACUUUGUGAUCAUUACAGAAAGUCUG
00153283-		ID	GUGUAAGGUGUUCAGAAGACA
ENST000		NO:
00494798-		675
56
ENSG000	1.202250959	SEQ	ACACUCAGUUUUGAACACACGGUGACACCUGAGAA
00153303-		ID	GC
ENST000		NO:
00336070-		676
37
ENSG000	1.688431066	SEQ	AUUCAUUUGAGUGGGAAUCUCAAAGCAGUUGAGUA
00153802-		ID	GGCAGAAAAAAGAACCUCUUCAUUAAGGAUUAAA
ENST000		NO:
00283916-		677
69
ENSG000	1.180284691	SEQ	UAAUCAGCUGUAAGUGCCGUCACUGGAUAGAAGGU
00153814-		ID	CCGUCCUUGGGUCUGU
ENST000		NO:
00430432-		678
51
ENSG000	1.300920619	SEQ	AUACAAAAACAUCAUAGUUAAGUAAACUCACCAGA
00154165-		ID	UUUGGCAUCUGCUCUUUGGUG
ENST000		NO:
00284311-		679
56
ENSG000	1.534661839	SEQ	AGUAACUGUGUUUCUAGAUUUUUCCUCCAGCUUUC
00154258-		ID	CUGAGAGAAACAGGUCAAA
ENST000		NO:
00495634-		680
54
ENSG000	1.348255679	SEQ	AUACAGUUUCUCUUUGCCAGACUAGACUAAAGAAG
00154269-		ID	GAGCACUAAUUUAUUCUGAUAAAACAGGUCUAGUC
ENST000		NO:	AGCUACCAGGACA
00357639-		681
83
ENSG000	1.316702052	SEQ	ACAGUUUCUCUUUGCCAGACUAGACUAAAGAAGGA
00154269-		ID	GCACUAAUUUAUUCUGAUAAAACAGGUCUAGUCAG
ENST000		NO:	CUACCAGGACA
00423831-		682
81
ENSG000	1.233629493	SEQ	AGCUGUUUUUCGUCUUCCCUAGGCUAUUUCUGCCG
00154277-		ID	GGCGCUCCGCGAAG
ENST000		NO:
00284440-		683
49
ENSG000	1.301628321	SEQ	UAUUGCUAGACCACCUUGCUUGGAAUUAAAAGUUA
00154310-		ID	CACAGUUAUUUUUCCCAGAACAGUUAUUUUCAGCU
ENST000		NO:	UAAGGA
00468757-		684
76
ENSG000	1.103263975	SEQ	ACUUUUCCAGAUCUAGGAGCAUCAGUGACACCUCG
00154479-		ID	UCAGAGAGUCUGGUACGGUUUGGACGGCGCUGUGG
ENST000		NO:	ACGGGCGAAGGAAAGUACAGGGG
00421028-		685
93
ENSG000	1.147633269	SEQ	UUUUCAGGCCAAAAGGUGUGUUUUGCUGACUUCAA
00154645-		ID	GCAUCCCUGCUACAAA
ENST000		NO:
00338326-		686
51
ENSG000	1.486960459	SEQ	GCGUGGCAGUUGAAAGAGUGGCGGGAGAAGUUGCA
00154920-		ID	GGGAAUUAUUUGAUAGCACAUACUG
ENST000		NO:
00511711-		687
60
ENSG000	1.313618755	SEQ	UGCCAAUCAUUGUGACAUUUUUCUGAUUUUUUUU
00155249-		ID	UUUAGGUAACUGAAUAUUGGAUAC
ENST000		NO:
00285600-		688
59
ENSG000	1.460542016	SEQ	AGUUGUUUCUGUAACAGCAGAAAGUGCACUCACUA
00155307-		ID	GGAGUAGUCAGAAUUCAAA
ENST000		NO:
00400566-		689
54
ENSG000	1.212930496	SEQ	CUUCCGGGCAAA
00155463-		ID
ENST000		NO:
00442110-		690
12
ENSG000	1.214818394	SEQ	CUCUUCCGGGCAAA
00155463-		ID
ENST000		NO:
00612549-		691
14
ENSG000	1.14747866	SEQ	GUUCGCCCUAAAGGUACCAAU
00155545-		ID
ENST000		NO:
00381199-		692
21
ENSG000	1.13181364	SEQ	UCGUUCGCCCUAAAGGUACCAAU
00155545-		ID
ENST000		NO:
00381213-		693
23
ENSG000	2.132610821	SEQ	UUCGCCCUAAAGGUACCAAU
00155545-		ID
ENST000		NO:
00452157-		694
20
ENSG000	1.232923977	SEQ	UGACAGAAGCGUCAAUUCCUGGGAGUAGUUCGUUG
00155621		ID	GUUUUCUUUCCCCUCAUCCUUUUGCCUGCUCCCGGC
ENST000		NO:	GAGGGGUGGCUUUGAUUUCGGCG
00473252-		695
94
ENSG000	1.094757446	SEQ	GAAGUUUGAGCCUCUUUGGUAGCAGGAGGCUGGAA
00155659-		ID	GAAAGGACAGAAGUAGCUCUGGCUGUG
ENST000		NO:
00412866-		696
62
ENSG000	1.806665059	SEQ	AGAGCUGGAAUCUCUGCACGGGCCUUGGAAAACGA
00155827-		ID	CUGUCUUCUUCUGCCAAA
ENST000		NO:
00374819-		697
53
ENSG000	1.25660662	SEQ	AGUUUGAACUUACAAUACUUAAGUCCUGGCAAGUC
00155833-		ID	AUAAGUGGGGAAA
ENST000		NO:
00374798-		698
48
ENSG000	1.226924038	SEQ	ACAAUACUUAAGUCCUGGCAAGUCAUAAGUGGGGA
00155833-		ID	AA
ENST000		NO:
00487798-		699
37
ENSG000	1.379887787	SEQ	GAGUUCACCUUUCAACAUCACCAGUUUGAACUUAC
00155833-		ID	AAUACUUAAGUCCUGGCAAGUCAUAAGUGGGGAAA
ENST000		NO:
00612124-		700
70
ENSG000	1.175313108	SEQ	CGGCUGCAGAGGGGAAGGCGGCUACCAGUGUAAAG
00155868-		ID	CCAGAGCUGAGGUUCUUGAUAGUCCACA
ENST000		NO:
00286317-		701
63
ENSG000	1.809713411	SEQ	GACAGUUUCCCGAUUUGAGGUGAAACCAGUAAGAG
00155893-		ID	AAAAUAGAAUACUUAAUA
ENST000		NO:
00637579-		702
53
ENSG000	1.195673929	SEQ	GCUGUUGCCAUC
00155957-		ID
ENST000		NO:
00613669-		703
12
ENSG000	1.244232447	SEQ	ACACUUUGCCACAGAAAGCAGUGAGCAAGA
00155974-		ID
ENST000		NO:
00545666-		704
30
ENSG000	1.204091313	SEQ	ACUUUAUUACAGACCUUGGAAGCAAGAGGAUUGCA
00156006-		ID	UUCAGCCUAGUUCCUGGUUGCUGGCCAAAGGGAUC
ENST000		NO:
00286479-		705
70
ENSG000	1.911499754	SEQ	UUUGUACUUCCUGAGAGAAGGCAGAGAAGAAGAAG
00156026-		ID	UUUUUAUUACAUAGAGUAAC
ENST000		NO:
00604152-		706
55
ENSG000	1.101524448	SEQ	AGAAAGGAGCAGCAACUGGAAAACAAGCAUUGCAU
00156096-		ID	UGCAUCAGG
ENST000		NO:
00305107-		707
44
ENSG000	1.416432995	SEQ	ACAGCCUGGACUCAGAGCUCAAGUCUGAACUCUACC
00156234-		ID	UCCAGACAGA
ENST000		NO:
00682537-		708
46
ENSG000	1.381627379	SEQ	AUACACAAGAAGUUUCAGGAGUCAGAGGAGGGUUG
00156273-		ID	AGUAUAAUUAGAAGCAGUCUUUCCACUGAACUUCC
ENST000		NO:	CGACAACAUUUGUUAGUCAGA
00447177-		709
91
ENSG000	1.172091281	SEQ	UCUCUUUCUGGUCAAA
00156467-		ID
ENST000		NO:
00521036-		710
16
ENSG000	1.380721414	SEQ	UUAAAUAAGUAGGGAUUGUUUAAAAAAAAAAGCUG
00156687-		ID	UAAUAGUUUAUCUGGGGGUGG
ENST000		NO:
00453357-		711
56
ENSG000	1.117138641	SEQ	UCUAGCGAAAUAGUGCUACAGAGAGCCCUGCUACG
00156958-		ID	CGUCGGGUCCAGGUUACUGAAGCUAAAGGAG
ENST000		NO:
00559423-		712
66
ENSG000	1.383482115	SEQ	AUUGACUUGAGUCAAAACAUCACAAAGGCUCCAUA
00157106-		ID	UUAUACAGU
ENST000		NO:
00565224-		713
44
ENSG000	1.303449037	SEQ	ACUCCCCUGGCAGACCCCGCCAAGCGCCUCGGAGCG
00157303-		ID	CGCAGG
ENST000		NO:
00375472-		714
42
ENSG000	1.176651374	SEQ	GGUCAGAGAGAAGCAAUAAUUAUUAUUAACAUUUA
00157554-		ID	UUAACGAUCAAUAAACUUGAUCGCAUU
ENST000		NO:
00398905-		715
62
ENSG000	1.10797867	SEQ	UUUACUUUUCUUUUAUUAGGUUGUUUGCU
00157578-		ID
ENST000		NO:
00380671-		716
29
ENSG000	1.125559456	SEQ	CUUACUUUGCAAAGAAGGAAG
00157601-		ID
ENST000		NO:
00619682-		717
21
ENSG000	1.530186557	SEQ	CAGGACGUCUUCCAGAGUGUGUUUUUUGGCUACAG
00157703-		ID	UGUUUUCAGUAUCCUCUUUGGCCUCCUGGCUGACA
ENST000		NO:	GAU
00436657-		718
73
ENSG000	1.135989055	SEQ	GUUUUAUCUCCCUUUCUGUUUUGUUUGUGACCAGG
00157916-		ID	CAUAAAGCAGUCACCUUCAACAGUUACAGA
ENST000		NO:
00443438-		719
65
ENSG000	1.10366532	SEQ	AGGAGAGUUGCCAAACUGUUAAGAGUGGUUAUUUC
00158055-		ID	UGAGCAGAAGA
ENST000		NO:
00236255-		720
46
ENSG000	1.126411487	SEQ	ACAGAGCAGUGAUAACUACCUGCCAGUGUCUCUUA
00158125-		ID	GGAGUGAGGUACCUGGAGUUCGGGGACCCCAACCU
ENST000		NO:	GUGACA
00379416-		721
76
ENSG000	1.166225024	SEQ	AGUGUUCUAACUAUUAACGCUACG
00158373-		ID
ENST000		NO:
00289316-		722
24
ENSG000	1.274062176	SEQ	CCUGUCAUUCGUUCGUCCUCAGUGCAGGGCAACAGG
00158578-		ID	ACUUUAGGUUCAAG
ENST000		NO:
00493869-		723
50
ENSG000	1.727126472	SEQ	UUCUUUUUGGAUUGAAGCCUUUUCCCCACGACUCU
00158941-		ID	GAAAGAGGACAGCGUUCCCA
ENST000		NO:
00523349-		724
55
ENSG000	1.482570527	SEQ	AUUAGAUAUUUCAUCUUACUGCAGAGCAUAGAAUC
00158987-		ID	AAUAGGAGCUUCUCCUUAGGGAGCUGCUUUGAAAC
ENST000		NO:	AGCUUCCAGCUGAUCUUACCAAG
00513227-		725
93
ENSG000	1.12745884	SEQ	GUCCAUUCUUCCGGUGGAG
00159111-		ID
ENST000		NO:
00421763-		726
19
ENSG000	1.427199471	SEQ	CUUCCGGUGGAG
00159111-		ID
ENST000		NO:
00423147-		727
12
ENSG000	1.20729524	SEQ	AGUCUGGGAGCCUGGAGGACUAGCGAGGAGGAGUU
00159140-		ID	GAGAGAACGGAGCGGACGCC
ENST000		NO:
00356577-		728
55
ENSG000	1.276294002	SEQ	GCUACCGUGACUAAG
00159377-		ID
ENST000		NO:
00290541-		729
15
ENSG000	1.126393286	SEQ	AUCUUCUUGCCAUUCAGUUGUAGAUCUUUGAAGAC
00159516-		ID	UCUGAUUCUCUGAGACUGAGGAGAG
ENST000		NO:
00368748-		730
60
ENSG000	1.422864852	SEQ	UUUUUCCUCUGCGAAUAGUGUUUUCUGAUUAACUA
00159708-		ID	CUAGUUAGUUCUAGUCCAAAAAAAGAAAC
ENST000		NO:
00435835-		731
64
ENSG000	1.158459245	SEQ	GCAGGUCCCACCUUGUGGAGG
00160049-		ID
ENST000		NO:
00476658-		732
21
ENSG000	1.36178054	SEQ	ACUUCCGGUGUUACCUGUGUCGUUACCGGGAGCUG
00160588-		ID	UAAACAAGGUGUGCAAGCAUCUGAAGAGCUGCCGG
ENST000		NO:	G
00278949-		733
71
ENSG000	1.675653398	SEQ	GUCGUUACCGGGAGCUGUAAACAAGGUGUGCAAGC
00160588-		ID	AUCUGAAGAGCUGCCGGG
ENST000		NO:
00525386-		734
53
ENSG000	1.293935903	SEQ	CUCAACUUCCCUAGUCAGUGACGCGGCGCCGGCCAG
00161217-		ID	AAAUCCGACCGGACCGGGCUCGGGGGAGCGUGAGU
ENST000		NO:	UGCAGUUAAAAGAAG
00441879-		735
86
ENSG000	1.389024992	SEQ	CUGGCCUUCUCC
00161249-		ID
ENST000		NO:
00436012-		736
12
ENSG000	1.258751599	SEQ	CCAGACCUGGAGGGCUUGGGUAAAA
00161265-		ID
ENST000		NO:
00601236-		737
25
ENSG000	1.194196332	SEQ	ACUUCCGGAACAAGCGUCGCGUUUCUGAGGAGAAA
00161920-		ID	CUCUUGGUGAGAAUUCCCAGAGUGAUA
ENST000		NO:
00293777-		738
62
ENSG000	1.296649421	SEQ	CUAGUUUCUAAGGAUC
00161960-		ID
ENST000		NO:
00578476-		739
16
ENSG000	1.190368102	SEQ	ACACUGGCCCUUGCUUUGGAGUCAGGAGGCCUCUCU
00162078-		ID	UCUUCCCACAGAGCCCUGGG
ENST000		NO:
00572863-		740
56
ENSG000	1.191410773	SEQ	CUUUUAUUGCUUUUGUACAAGACCAGACAGGAUCU
00162086-		ID	CAUUUGUUAAACGUGGUACCAAUUGGGUGUCUUAA
ENST000		NO:	CACAGGAGCAGAACUUCCUAGAGCAGA
00612186-		741
97
ENSG000	1.595056086	SEQ	CAGCCAGUCCUGAGCACCUAACC
00162438-		ID
ENST000		NO:
00375943-		742
23
ENSG000	1.372891159	SEQ	GUCACCGCUUUCGCUUCUGCUUGAGUAGUCAAGUG
00162600-		ID	AAAAA
ENST000		NO:
00371226-		743
40
ENSG000	1.146783963	SEQ	UGGAGAAAAGCCAAACAAUUGCAGUUUUCCAUAUU
00162601-		ID	UUAGAGAAAAUAAAUUAAUCAGUCUCAGUUUUCU
ENST000		NO:
00622766-		744
69
ENSG000	1.242603249	SEQ	UGACAGCAGCCAGCUCAGGAGGCAGAGGACGAGAG
00162641-		ID	CGAUCGGGCUGCACACAC
ENST000		NO:
00369994-		745
53
ENSG000	1.196267171	SEQ	UUAUCUGCAGAGAUCAGGCCAAAGGGAGCUCUAGA
00162735-		ID	AGGUUGUUGGGGAGCACUAAACUGGAGAAUAAGAG
ENST000		NO:	AAGAUAGUUUAAGUCCGUACC
00392220-		746
91
ENSG000	1.27790561	SEQ	CAGACAGGAGCCGAACGGGGGCUUCCGCUCAGCAGA
00162736-		ID	GAGGCAAG
ENST000		NO:
00437169-		747
44
ENSG000	1.115541037	SEQ	UCUUCCCUAUCCCUAGUUCCAAAAG
00162929-		ID
ENST000		NO:
00356719-		748
25
ENSG000	1.662013999	SEQ	AGUGUCCAGAAGUCUGGAGCGUAGGUGAAAGGACA
00163072-		ID	AAAGCCAGACACAUUUCAAC
ENST000		NO:
00439509-		749
55
ENSG000	1.519405663	SEQ	AGCAUAUUUCAUUUUCUGUCAUUGGACUUUGAGCC
00163110-		ID	AUUAGAACC
ENST000		NO:
00508216-		750
44
ENSG000	1.390898977	SEQ	UGAACUGAAAUCUCCUUGUUGCUUUGAAAUCUUAG
00163131-		ID	AAGAGAGCCCACUAAUUCAAGGACUCUUACUGUGG
ENST000		NO:	GAGCAACUGCUGGUUCUAUCACA
00680311-		751
93
ENSG000	1.430130946	SEQ	CAGCACUCCACCAAAGCCUCUGCCUCAGCCUUACUG
00163207-		ID	UGAGUCUGGUUGACAGUAGCUUCUAAG
ENST000		NO:
00368764-		752
63
ENSG000	1.642518385	SEQ	UAAACUCCUGGUACUCUAGCACCGAUCUGCUUUGG
00163216-		ID	AGAACCUGAUCCUGAGACUCCAGCAGG
ENST000		NO:
00360379-		753
62
ENSG000	1.40718731	SEQ	UAUAAUUUCGUACAGCAACUUGCGGAGAGAUUUGU
00163297-		ID	GAGCCCUGAA
ENST000		NO:
00449651-		754
45
ENSG000	1.275629366	SEQ	ACAGCUGGCAUUCAGCCUCCAGAGCACCAGCACUGG
00163331-		ID	CACUGGCACUGGCACACGCU
ENST000		NO:
00309950-		755
56
ENSG000	1.111938635	SEQ	CUUCCUCGGAACUGUUGCCCAC
00163352-		ID
ENST000		NO:
00368427-		756
22
ENSG000	1.10833621	SEQ	AGAAUACGGUGAGAAAUUCCAGGAGCACAGAAGUC
00163354-		ID	AGCGGGCAUCUCCUGGAGACAGGCAGACAUUUGGU
ENST000		NO:	CUCAGCAGCC
00368424-		757
80
ENSG000	1.22356696	SEQ	CUUUCUUGGCCAGAGGCGCCGGUUGGACUCACGGGC
00163463-		ID	GGGGCAGU
ENST000		NO:
00482246-		758
44
ENSG000	1.209765684	SEQ	GAGAAUUGCUUCCUGAGAAGGUAAGUA
00163468-		ID
ENST000		NO:
00446905-		759
27
ENSG000	1.220822728	SEQ	CUCUUCCUGUCUUUGUGGCUCCGGAAAGGCGUUUG
00163479-		ID	GGAGUCCAACG
ENST000		NO:
00496742-		760
46
ENSG000	1.584138237	SEQ	ACUGUCAGCUUUGAACACUGAACGCGAGGACUGUU
00163600-		ID	AACUGUUUCUGGCAAAC
ENST000		NO:
00316386-		761
52
ENSG000	1.126515178	SEQ	AGUAUAUUAGUGCUAAUUUCCCUCCGUUUGUCCUA
00163631-		ID	GCUUUUCUCUUCUGUCAACCCCACACGCCUUUGGCA
ENST000		NO:	CA
00621628-		762
73
ENSG000	1.156801668	SEQ	ACAGAAGCCGUUUCUCAUC
00163646-		ID
ENST000		NO:
00327047-		763
19
ENSG000	1.157314453	SEQ	AGAAUCCAGCACUCCAAGCACUGCUGUCUUCUCACA
00163687-		ID	GAGUCUUGAAGCCAGAGCAGCGCCAGG
ENST000		NO:
00486455-		764
63
ENSG000	1.141606568	SEQ	ACCUUCAGGCCAGUCAGCCAGUUUCCGGGAGCCCUA
00163701-		ID	AUUGCACAGAAGCCC
ENST000		NO:
00454992-		765
51
ENSG000	2.057044302	SEQ	AGGUGGAGGAG
00163743-		ID
ENST000		NO:
00507014-		766
11
ENSG000	1.222486514	SEQ	GUAUCUGCCCAUCUUAGAUUCUUCCUAGCAAUAAU
00163746-		ID	UCUGAGAGACUCUGGAUUGUGGGCCGAAGUGAGA
ENST000		NO:
00613069-		767
69
ENSG000	1.196060089	SEQ	CAAAGAAGAACC
00163751-		ID
ENST000		NO:
00296046-		768
12
ENSG000	1.371076129	SEQ	AGAGAUAGAGUCUUCCCUGGCAUUGCAGGAGAGAA
00163810-		ID	UCUGAAGGG
ENST000		NO:
00422219-		769
44
ENSG000	1.421708959	SEQ	UCAUUCAAGUGAGUAAGUUAAGAAGUGCCAAGGGU
00163885-		ID	GAGGAUCUCCUUUAGAAGAGGAGAAGCCUUGCAUC
ENST000		NO:	AACCUCUUGGGCCUCAGCCAAG
00510833-		770
92
ENSG000	1.644096472	SEQ	AGGUGAAAAAUUAGACGAUUUCAAGAAUUGGAGCU
00164118-		ID	GAAUCUGAGUUUAAGUA
ENST000		NO:
00296519-		771
52
ENSG000	1.221022678	SEQ	GUAAGUUUUUUUUGGUUGCUGACAAAGUUCUUUUU
00164129-		ID	AUUCCAAGCAGGACUAUAAU
ENST000		NO:
00506953-		772
55
ENSG000	1.538892719	SEQ	UUACACUAAGAACUCUUUGUUACAUCAGGUAUUGC
00164164-		ID	ACUCUCAGUCUCGCCAGUUUGAAGUCAGA
ENST000		NO:
00509620-		773
64
ENSG000	1.583020697	SEQ	AUUAUAAACUCAUUUCUGUUUUAUUUUACUGAAGA
00164181-		ID	ACCCAUUAAAAGAGCCAGUAAAUCCUGUGGAAA
ENST000		NO:
00504455-		774
68
ENSG000	1.129415916	SEQ	AGAAACAUUCAGAUUCUCCAGAGAAAGUUGUAUUU
00164483-		ID	ACAGGAGACAGCA
ENST000		NO:
00529723-		775
48
ENSG000	1.184568011	SEQ	ACAGCACGCUGCCACGCCGACGCAGACCCCUCUCUG
00164687-		ID	CACGCCAGCCCGCCCGCACCCACC
ENST000		NO:
00297258-		776
60
ENSG000	1.176135501	SEQ	ACAUAUCCACUCCUGCUCUCCCUCCUGCAGGUGACC
00164816-		ID	CCAGCC
ENST000		NO:
00330590-		777
42
ENSG000	1.525410616	SEQ	ACUCUGCAUUUCUUUCCCGCCCUCUGCAGUAGUGUU
00164828-		ID	UGAAGUGGUGAAC
ENST000		NO:
00401592-		778
49
ENSG000	1.215169189	SEQ	AGCACGGUUCGUUUUUCCUUUAGUCAGGAAGGACG
00164919-		ID	UUGGUGUUGAGCAUACGUAUCAAGGACAGUAACUA
ENST000		NO:	CC
00297564-		779
72
ENSG000	1.216700317	SEQ	UUUCCGGCUCCGGUGUC
00165055-		ID
ENST000		NO:
00497665-		780
17
ENSG000	1.106943014	SEQ	AGGGCGGAGCGGGCGGCAGACCCGGAGCAGC
00165060-		ID
ENST000		NO:
00484259-		781
31
ENSG000	1.471090327	SEQ	AGUCAUCUUUAUCCCUUUAAGCAGUGUUUAUUUUC
00165120-		ID	UGAGCAAGGAGUCAUC
ENST000		NO:
00297819-		782
51
ENSG000	1.528556817	SEQ	ACAUUCAACCUCUGCCACC
00165168-		ID
ENST000		NO:
00378588-		783
19
ENSG000	1.428969599	SEQ	AGGAAGAGAGUCAGGAGGCGAUUUUUACCUCAGAG
00165181-		ID	UUUGAAAUUUACACUGCUUUGAAAGAAAGAAGAU
ENST000		NO:
00683944-		784
69
ENSG000	1.256873376	SEQ	AGACCUCUCGGGCGAGCGCGGCGCAGCGCAGAUUAA
00165325-		ID	AAAUCAAGAAAUAUAAACCAGAGUUAGCAGUUUCU
ENST000		NO:	UGAC
00298050-		785
75
ENSG000	1.431428471	SEQ	AUUAAAAAUCAAGAAAUAUAAACCAGAGUUAGCAG
00165325-		ID	UUUCUUGAC
ENST000		NO:
00532819-		786
44
ENSG000	1.414595795	SEQ	GAGAAGUAGGCGAUUUCGGAGGAGUGAGAAAUAGC
00165409-		ID	CCCGAGUCCCGUGGAAA
ENST000		NO:
00555326-		787
52
ENSG000	1.545112709	SEQ	CUUCCUUGUAAG
00165526-		ID
ENST000		NO:
00298317-		788
12
ENSG000	1.156547604	SEQ	UUCCAGGAUCAGAAGUACUGAGGAGCAGAGCCAAU
00165555-		ID	CUUCUCUGUUUGGAAAUAGUGGCUUGGAA
ENST000		NO:
00555603-		789
64
ENSG000	1.241647736	SEQ	AGUUGUUCUCAGGUGUUUGGGCUUGUUGUUCCGUA
00165630-		ID	UACUCAGUGGGUUCGCGGCCGCCGGCCCAGUGAGGC
ENST000		NO:	UGGGUUCGAGGAGCUGGAGCGGGAAACUGGAGCUU
00378572-		790	AAAUUCUGGCGGCGAG
122
ENSG000	1.148512534	SEQ	GCGAGUUUGACGGGGUCCUAAGAGUGCUGCUGGGC
00165669-		ID	GACCACUUCCUGACAGAAGAAAAG
ENST000		NO:
00369172-		791
59
ENSG000	1.10941127	SEQ	ACUCUUGUUGCAUCAUCAGCGUGCACCUCCACGAGU
00165832-		ID	AAACAGGUCUGGGCUACAAAAGU
ENST000		NO:
00298746-		792
59
ENSG000	1.229538326	SEQ	GUCAGCUUCACAUUCUCAGGAACUCUCCUUCUUUGG
00165949-		ID	GUCUGGCUGAAGUUGAGGAUCUCUUACUCUCUAGG
ENST000		NO:	CCACGGAAUUAACCCGAGCAGGC
00620396-		793
94
ENSG000	1.351093994	SEQ	CAAACCCAGUCUUGUCAAUAGCGGGUUUCACCCUCC
00165970-		ID	ACCAGUUCAGUCUGUUGCCUGUGUCAGAC
ENST000		NO:
00525748-		794
65
ENSG000	1.409596512	SEQ	AGAAAAAAGAAAUCCUCUUUUUAGAACAUCUCUUG
00165983-		ID	GUGGUACCAUCAGAA
ENST000		NO:
00298942-		795
50
ENSG000	1.273258764	SEQ	GUUUCUCUCCGCAAGCGCGCG
00166123-		ID
ENST000		NO:
00562132-		796
21
ENSG000	1.102281595	SEQ	GUCAGAGGGCCGGAGCGAGAAG
00166128-		ID
ENST000		NO:
00559927-		797
22
ENSG000	1.226043733	SEQ	AAACGUGAAGAAGGUGAAG
00166136-		ID
ENST000		NO:
00528425-		798
19
ENSG000	1.316731002	SEQ	AAACAGAUACCAGUGAGUAGUUUGAAACAGGAACA
00166199-		ID	AAAUCUUCUGAAAGCUCGGAGCAGAAGCCUUUUUG
ENST000		NO:	GUCAAC
00529366-		799
76
ENSG000	1.152093597	SEQ	CUCUCUUUGUCCAACGUAGAAGAGACA
00166329-		ID
ENST000		NO:
00299415-		800
27
ENSG000	1.836787708	SEQ	GAAAUCUGUCUUUGUUGCUCUGGGAGAGGGGACUC
00166352-		ID	CUGGAAGUUGUCUGUGAAUAAAGACUAGCCGAAGA
ENST000		NO:	UACUGUGGCCUCAGUAAUAGGA
00676885-		801
92
ENSG000	1.266002899	SEQ	UCUUCCCUUCUUUGUAGUUCAGGAUUCGCCCAAA
00166415-		ID
ENST000		NO:
00559418-		802
34
ENSG000	1.3308146	SEQ	CUUUUUCGUCUGGGCUGCCAAC
00166441-		ID
ENST000		NO:
00314138-		803
22
ENSG000	1.411305208	SEQ	CAGAAGAUACUUGUGUUUUCCUGUAGUUGACAAAA
00166478-		ID	AACGGUAGAAG
ENST000		NO:
00417726-		804
46
ENSG000	1.164322509	SEQ	AGUGUCUUUAUCCCUCUUUUGCACAGUCAGCUUCU
00166479-		ID	GCAGCUCUCCCGGGCUAGC
ENST000		NO:
00569053-		805
54
ENSG000	1.391687773	SEQ	AACACUCCUGAGGAGAAAGAAAGAGAGGGAGGGAG
00166523-		ID	AGAAAAAGAGAGAGAGAGAAACAAAAAACCAAAGA
ENST000		NO:	GAGAGAAAAA
00446457-		806
80
ENSG000	1.12078269	SEQ	GGAGGUUUUCUCUUGGGUUUGUUUGGAUUUUUUUU
00166569-		ID	UUCAGCUUUUGUCUGAAUUUUGGUUUUAUUUUUCU
ENST000		NO:	GGGGCAGAGAAA
00587244-		807
82
ENSG000	1.305837737	SEQ	CAGCCCUUGCCAGCAUCCAGCC
00166716-		ID
ENST000		NO:
00299927-		808
22
ENSG000	1.344619977	SEQ	GCGGAGCGGCAGGAGUCAGGAGGAGCUGGCGUGGG
00166839-		ID	AGACCGACGGCCUUUGGG
ENST000		NO:
00496660-		809
53
ENSG000	1.313277674	SEQ	CGGGCCAAGCCUACCGGGGGUCACAAUUUGGGUCU
00167528-		ID	GCAGCAGAA
ENST000		NO:
00549125-		810
44
ENSG000	1.24220233	SEQ	ACAGUGAAAAAGCAGUCUGGCUCCCGAGGUCCACCC
00167615-		ID	CUUAUACCCCAAGGUCCAG
ENST000		NO:
00610347-		811
55
ENSG000	1.107255084	SEQ	UUCUUCAGCCUUAACCUAAGGUCUCAUACUCGGAGC
00167634-		ID	ACU
ENST000		NO:
00328092-		812
39
ENSG000	1.26005911	SEQ	ACAGCCCACCAGUGACCACGAAGGCUGUGCUGCUUG
00167653-		ID	CCCUGUUG
ENST000		NO:
00301258-		813
44
ENSG000	1.416393545	SEQ	AAACGUGCCCCUUCACCGGAACCGAGCAACGGUAAC
00167693-		ID	UGUGCCCCUUCACCGGAACCGAGCA
ENST000		NO:
00575801-		814
61
ENSG000	1.235074399	SEQ	UAGUGCAAGUAAGAAAGAAACUGAAUUUGUCAUUU
00167904-		ID	UCACCUGAAGAAAA
ENST000		NO:
00522030-		815
49
ENSG000	1.311760597	SEQ	AGUGGCAUCCUUCCCUUUCUAAUCAGAGAUUUUCU
00167910-		ID	UCCUCAGAGAUUUUGGCCUAGAUUUGCAAA
ENST000		NO:
00301645-		816
65
ENSG000	1.377414837	SEQ	ACACUCUUCGUCAUCACCUCUCCUAUUCGCCUGGAC
00167916-		ID	AAGCUCAGUUUUGCAGGAGCACC
ENST000		NO:
00264651-		817
59
ENSG000	1.343453797	SEQ	GUAAAUCCGCCAUCUUCCUGCGGCGCGUUGCGAC
00167967-		ID
ENST000		NO:
00565090-		818
34
ENSG000	1.14438112	SEQ	AGAGACGACCUUAAGUGGACAGAGAUUCUAGAACA
00168070-		ID	GGAGAAAUAAAACAGCUAUCGUUUGGGAGCA
ENST000		NO:
00432175-		819
66
ENSG000	1.117737096	SEQ	UGCGUAUACAUACAUACUAGUUAGUUGCGUUUAGU
00168385-		ID	UGUGUCUGUGUGUUUUUUUUUUAACAGACGAAGCU
ENST000		NO:	UCACAAAAG
00449239-		820
79
ENSG000	2.183440562	SEQ	AGAGCAUAGCACCUGCAGCAAG
00168484-		ID
ENST000		NO:
00524255-		821
22
ENSG000	1.13522483	SEQ	GCUUUAAUAGGGAGAUCAAGAGUAAUUUGAGUUAU
00168502-		ID	AAUCAGAAUCCUAGAGUGAGGAGGAGCACCUCUAG
ENST000		NO:	UCCUUGAGGUGGAAAGAACUGGAA
00518815-		822
94
ENSG000	1.102748702	SEQ	ACACCUUCUGAGGCAGCGGC
00168925-		ID
ENST000		NO:
00361017-		823
20
ENSG000	1.435108539	SEQ	UUAAGUCGUUCCCUCUACAAAGGACUUCCUAGUGG
00168961-		ID	GUGUGAAAGGCAGCGGUGGCCACAGAGGCGGCGGA
ENST000		NO:	GAG
00577392-		824
73
ENSG000	1.255378288	SEQ	AAGUUGCUUUGGUUUCUAUUUCUUUGUUAAGUCGU
00168961-		ID	UCCCUCUACAAAGGACUUCCUAGUGGGUGUGAAAG
ENST000		NO:	GCAGCGGUGGCCACAGAGGCGGCGGAGAG
00580779-		825
99
ENSG000	1.22432666	SEQ	GAUUAUUAAGUUCCUGCAACUUAACUGGGAACUGA
00169239-		ID	UCAAGAUUUCAAGCUAAAG
ENST000		NO:
00454127-		826
54
ENSG000	1.380880693	SEQ	ACAGAGUCUCUUUCCAGUCC
00169282-		ID
ENST000		NO:
00475456-		827
20
ENSG000	1.264156377	SEQ	ACAAGCUCAGCG
00169299-		ID
ENST000		NO
00512556-		828
12
ENSG000	1.109415953	SEQ	AGAACAACCAGCUGGAUCAGUUCUCACAGGAGCUA
00169385-		ID	CAGCGCGGAGACUGGGAAAC
ENST000		NO:
00304625-		829
55
ENSG000	1.802634697	SEQ	GUAAUAGUGUUUUAAGAAUAUUUCAGCGUAGUAGA
00169398-		ID	GGAUUUAAGCAGAUCGCUUUGCCUACUUUAAUUAU
ENST000		NO:
00519024-		830
70
ENSG000	1.44833275	SEQ	GUUUUAAGAAUAUUUCAGCGUAGUAGAGGAUUUAA
00169398-		ID	GCAGAUCGCUUUGCCUACUUUAAUUAU
ENST000		NO:
00520151-		831
62
ENSG000	1.149006677	SEQ	AAUAGUGUUUUAAGAAUAUUUCAGCGUAGUAGAGG
00169398-		ID	AUUUAAGCAGAUCGCUUUGCCUACUUUAAUUAU
ENST000		NO:
00523670-		832
68
ENSG000	1.393839725	SEQ	AUAACACCUAGUUUGAGUCAACCUGGUUAAGUACA
00169605-		ID	AAUAGUAGAAGGCUUCUCAUUCAGGUCC
ENST000		NO:
00673932-		833
63
ENSG000	1.137406067	SEQ	ACUGAAGAGUC
00169607-		ID
ENST000		NO:
00302450-		834
11
ENSG000	1.3820307	SEQ	UCAGAGCUCUCAAGCACCCACG
00169756-		ID
ENST000		NO:
00414829-		835
22
ENSG000	1.321902051	SEQ	GUUAGUAGUACCGUCGCUUUCCUGGAUAGUGGCUA
00169764-		ID	UCUUAGCAAAGCA
ENST000		NO:
00475462-		836
48
ENSG000	1.220633954	SEQ	UCCAGACAGGACUGUCCAGAGCAACGGUGUGCCAG
00169783-		ID	AGAGACUGAGAAGUACCCAGAA
ENST000		NO:
00557798-		837
57
ENSG000	1.654364873	SEQ	AAACUCCUCUUUGAUUCUUCUAGCUGUUUCACUAU
00169906-		ID	UGGGCAACCAGACACCAGA
ENST000		NO:
00380200-		838
54
ENSG000	1.103786962	SEQ	ACUCUCCUGUAAAACGCUAGAGCGGCGAGUUGUUA
00169976-		ID	CCUGCGUCCUCUGACCUGAGAGCGAAGGGGAAAGC
ENST000		NO:	GGCGAG
00367569-		839
76
ENSG000	1.217667466	SEQ	GCAGUUCCGGUGAGUCCGUGG
00170043-		ID
ENST000		NO:
00571947-		840
21
ENSG000	1.132252954	SEQ	AGCUACAACCAAGUAAGCAAGUGUCAGGGCUCACC
00170054-		ID	AACCAGUCAAGGACAGGGCAGGAGAAGAGGAACCU
ENST000		NO:	GCAAAGACAUAUUUUGUUCCAAA
00298845-		841
93
ENSG000	1.277076802	SEQ	AAGUCAUUCCUUCUGCAAAGGACUGCCUGGCAGGU
00170298-		ID	GUGAAAGGCAGCGGUGGCCACAGAGGCGGUGGAG
ENST000		NO:
00423676-		842
69
ENSG000	1.329092069	SEQ	AGCCCUUGCGCCCUGUUUGUGCCAGCAGGCACCAGC
00170325-		ID	GAACCAAAAGCAGGUGUCC
ENST000		NO:
00526082-		843
55
ENSG000	1.347256771	SEQ	CCGGAACGUCUUUUUGCGGACGCCCUCGGAGCAGCC
00170390-		ID	GCG
ENST000		NO:
00411937-		844
39
ENSG000	1.106061418	SEQ	ACACACACAUCUGCACCUCAACCACAGACUACACUU
00170476-		ID	GCUGAACUGGCUCCUGGGGCC
ENST000		NO:
00302125-		845
57
ENSG000	1.173639899	SEQ	CUGCUUUUCUCCAGCUCUGUCAACUCAACCUUUCCC
00170484-		ID	ACC
ENST000		NO:
00549343-		846
39
ENSG000	1.22328703	SEQ	ACAGGCCCUUGGUUCCAUCCUCUGCCAUCUACUCCA
00170523-		ID	CUGUUCAGACACCUCCUAACCUCCGUC
ENST000		NO:
00293670-		847
63
ENSG000	1.692965547	SEQ	ACAGAUCUGCCUCUUCUCCAAGAAACUCAACCACUA
00170545-		ID	GUGACA
ENST000		NO:
00380103-		848
42
ENSG000	1.655208685	SEQ	GCUGUUUAGAACUAUUGUACCGCUGCCAGUGACUG
00170579-		ID	UCUGUAUUAGGGUUGGGAGCAGGAAC
ENST000		NO:
00515196-		849
61
ENSG000	1.099285922	SEQ	UAGGGACGGGAAGUCGCGACCAGAGCCAUUGGAGG
00170581-		ID	GCGCGGGGACUGCAACCCUAAUCAGAGCCCAA
ENST000		NO:
00652624-		850
67
ENSG000	1.17560493	SEQ	AGAAGUCCUGUAGGGAGAGUGGCAGUUACCUUCUC
00170613-		ID	UCCGUCUCUCUCUCGGGGACUCUAUUUGUGGCUGG
ENST000		NO:	UGGAGCUGUCUUAAACGAAGAGAACC
00302938-		851
96
ENSG000	1.114255163	SEQ	CGAGCACUUGGAUUCAGCUUCUUCAUUUCCAAC
00170627-		ID
ENST000		NO:
00546931-		852
33
ENSG000	1.563860374	SEQ	CCAGUGAAGUCCUGGGCAGAAGA
00170782-		ID
ENST000		NO:
00379829-		853
23
ENSG000	1.264633689	SEQ	CACUUGACCUUCCAUCAGUAAGACGGACUUUUCUA
00170852-		ID	AUCUGUUCCUGGAGAUAUUAAGUGAAUACAGUC
ENST000		NO:
00621876-		854
68
ENSG000	1.112044721	SEQ	CUCUUUCUCAGUGACCGGGUGGUUUGCUUAGGCGC
00170889-		ID	AGACGGGGAAGCGGAGCCAAC
ENST000		NO:
00302907-		855
56
ENSG000	1.222934026	SEQ	UAAUUCAGCCACAUCUCCUCCUUCUCACUCAACUCA
00170954-		ID	GACCUCUCAGGAUAACUUGGUGAA
ENST000		NO:
00595174-		856
60
ENSG000	1.159693194	SEQ	CCUGACCGUAGUGCGGCCAGCAGUUGCAGGCAGACG
00170955-		ID	GAGCAGAGCGGUCAGGGAUC
ENST000		NO:
00530979-		857
56
ENSG000	1.509461646	SEQ	ACAGCAUUCCUGGAGCCCAGGCUCUUUUCCACAGAG
00170956-		ID	GAGGAAAGAGCAGGCAGCAGAGACC
ENST000		NO:
00415495-		858
61
ENSG000	1.533932631	SEQ	UUGAGUAAGUUCACUGGUGUGUCAUCAGUUUGCAG
00171109-		ID	UUCUAUCAUCCACUUUAGUUGGUGCUUUUCUAACU
ENST000		NO:	UUAUCUCCCUCUAGUAGCAUA
00263969-		859
91
ENSG000	1.373999542	SEQ	GCAGAGGUCACCGUCCAGGUUGGACAGCAGCACCUU
00171174-		ID	UGAGCG
ENST000		NO:
00302188-		860
42
ENSG000	1.36119849	SEQ	GCCGUCCGCGGAAAUUUGAA
00171241-		ID
ENST000		NO:
00303383-		861
20
ENSG000	1.451884879	SEQ	AAGCCUUCCAAACCCUCCUUCCUGGAAACCCACCCA
00171396-		ID	GAACCUCCACCCUCUGACACC
ENST000		NO:
00390661-		862
57
ENSG000	1.31453917	SEQ	UGGAAGUGCUCAAGUGUGGUAUACACUCAGGUGCA
00171405-		ID	UUUUUCCAAUCACAAUAUUCUGGACUGAAAU
ENST000		NO:
00351072-		863
66
ENSG000	1.357584551	SEQ	AAGAUUAUAGAGACUUGCUUUAGAACCACAAGAAG
00171533-		ID	AAAGAGGAGGCCGGCUUUUCAGCUAGCAUC
ENST000		NO:
00434603-		864
65
ENSG000	1.402997763	SEQ	AAUCCUUUCUUUCAGCUGGAGUGCUCCUCAGGAGCC
00171560-		ID	AGCCCCACCCUUAGAAAAG
ENST000		NO:
00403106-		865
55
ENSG000	1.743207923	SEQ	UUCUUCUUUUUUUCUCAAGAGAAUAUUUGACCUGA
00171681-		ID	GUUAAUUCUUGGAUCUCUGAGGUCUUCUACACAGA
ENST000		NO:	AGUAUAUUUAGAGAGCAAUUCAGA
00534828-		866
94
ENSG000	1.291928251	SEQ	AAACUAAGAGUAGUGCUGCAGCAAGCUCCCUCUUG
00171681-		ID	GAUUCAGA
ENST000		NO:
00539057-		867
43
ENSG000	1.339719472	SEQ	AAGUUGCUUUGGUUUCUAUUACUUUGUUAAGUCAU
00171916-		ID	UCCUUCUGCAAAGGACUGCCUGGCAGGUGUCAAAG
ENST000		NO:	GCAGUGGUGGCCACAGAGGCGGUGGAGAG
00577691-		868
99
ENSG000	1.276933056	SEQ	UGGUUUCUAUUACUUUGUUAAGUCAUUCCUUCUGC
00171916-		ID	AAAGGACUGCCUGGCAGGUGUCAAAGGCAGUGGUG
ENST000		NO:	GCCACAGAGGCGGUGGAGAG
00582333-		869
90
ENSG000	1.099509523	SEQ	CAUCGCUCUGUGUUUCCUGCUCCAGGUUUCGCGUCU
00171953-		ID	CGCAUCUUCCCAGACCCUCGGGCGCG
ENST000		NO:
00462733-		870
62
ENSG000	1.387947552	SEQ	CUGUUUGGAGUUGGAAGCCGAGACCUAAAGUUGGG
00172167-		ID	GGGUGAUCUCUGAGGAG
ENST000		NO:
00305949-		871
52
ENSG000	1.165971712	SEQ	GUGAGACUUCCAGAUCUUCUCUGGUGAAGUGUGUU
00172179-		ID	UCCUGCAACGAUCACGAAC
ENST000		NO:
00306482-		872
54
ENSG000	1.135030651	SEQ	ACAUCACAGAAGUAGAGGCAGACCUUGCUUCAGUA
00172215-		ID	GCAAGCUCAUCUCUGGAACAAACUGGCAAAGCAUC
ENST000		NO:	UCUGCUGGUGUUCAUCAGAACAGACACC
00304552-		873
98
ENSG000	1.197357555	SEQ	AGACAGUCAUCUCAGGAGCAGAAAGAAAAGAGCUC
00172243-		ID	CCAAAGUCUAUAUCUAUUCAGGGGCUCUCAAGAAC
ENST000		NO:	A
00298523-		874
71
ENSG000	1.411417369	SEQ	AUUUCCUGCUCUUGAAUAUCUGGUUGAACUACUUA
00172243-		ID	AGCUUAAUUUGUUAAACUCCGGGGCUCUCAAGAAC
ENST000		NO:	A
00529761-		875
71
ENSG000	1.14069491	SEQ	GGAAUAGGAAUC
00172270-		ID
ENST000		NO:
00614867-		876
12
ENSG000	1.162152591	SEQ	GCGAGGAAUAGGAAUC
00172270-		ID
ENST000		NO:
00618006-		877
16
ENSG000	1.37492807	SEQ	GUAGGACCGGCGAGGAAUAGGAAUC
00172270-		ID
ENST000		NO:
00680326-		878
25
ENSG000	1.528653385	SEQ	UUGCUUUAUUUCUCAUUGCUACAGGUCAUCUUAAG
00172365-		ID	UUUCUCAGAUAAUACUG
ENST000		NO:
00302581-		879
52
ENSG000	1.312636872	SEQ	ACUGGGUUGCUGAUCCAGCU
00172367-		ID
ENST000		NO:
00355547-		880
20
ENSG000	2.852381712	SEQ	AGAAUUUGAUUUGACUAUAUUUACCAUAUCAGAUU
00172410-		ID	CACAUUCAGUCCUCAGCAAA
ENST000		NO:
00304526-		881
55
ENSG000	1.225818801	SEQ	AUUGGAUUCCUGAUCUGAUUGAAGCCCAGAAGUGA
00172421-		ID	CAGAGUCACUGGCCAC
ENST000		NO:
00520404-		882
51
ENSG000	1.151508341	SEQ	UUGGGAUUUUGGAGUUGAGCACC
00172425-		ID
ENST000		NO:
00528570-		883
23
ENSG000	1.266011212	SEQ	UAAGUGUACAGUCUUAGGCCUUCUGAAGCAGCAUU
00172468-		ID	UGAAGCUGCAGUCCUGAAAACCAGUCAGGCCGGAA
ENST000		NO:	GAGUAGAUAAAGAAAUAUUUAUUUGAG
00309834-		884
97
ENSG000	1.277180577	SEQ	UUUGUUUUGUAGAUUGGUUGUUUCAUU
00172775-		ID
ENST000		NO:
00389447-		885
27
ENSG000	1.123937221	SEQ	CCCUCCAUUGCU
00173218-		ID
ENST000		NO:
00369509-		886
12
ENSG000	1.328926193	SEQ	AGUUUGUUGAAGUUCGUGACUGCUUCACUCUCUCA
00173391-		ID	UUCUUAGCUUGAAUUUGGAA
ENST000		NO:
00309539-		887
55
ENSG000	2.00761585	SEQ	AUUUUUAGUUUGUUGAAGUUCGUGACUGCUUCACU
00173391-		ID	CUCUCAUUCUUAGCUUGAAUUUGGAA
ENST000		NO:
00544577-		888
61
ENSG000	1.16294317	SEQ	AGCCCAGAAAGGAGCCACGGGGAGAAGCGGAGUUU
00173452-		ID	CUUCUUUGUGGCAUUUGUGGAAUAUUGUGUGCCAA
ENST000		NO:	AAAAAAAUCAGGACUUGUC
00422233-		889
89
ENSG000	1.180531783	SEQ	UCUUCCUUGCGGAAAUUUGCAUCGUGGGCUUGUAG
00173567-		ID	GGACUGCUUCACUGAGCC
ENST000		NO:
00421160-		890
53
ENSG000	1.793917021	SEQ	GUCAGUGGAGGCAGCAGCGGUAGAGGCGGCGGCGA
00173599-		ID	GGACUGGCGACGGCGAGGAGAUAGUGUCUGCCUUC
ENST000		NO:	UGGAGAGCUGACCAAACACUAAGG
00524491-		891
94
ENSG000	1.411983838	SEQ	AGUAUAUUCUGUUCUCUUGGGACAUUACAGUUUUG
00173908-		ID	CAUAGACAAGGUGAACAUUUCUCAAAACACC
ENST000		NO:
00306658-		892
66
ENSG000	1.167350608	SEQ	GCAAGUAGUACCUCAGGGUAAACUGCCAGAAGGCU
00174038-		ID	AAGGGAA
ENST000		NO:
00378745-		893
42
ENSG000	1.099566468	SEQ	GUCACAGAGGAG
00174175-		ID
ENST000		NO:
00367795-		894
12
ENSG000	1.906898622	SEQ	ACUUAGUUAAAUUUCAGUAACUAUUAUAUCCGUUU
00174371-		ID	UCCUCGGAGUGAGAGAAAACUCUUUUUAGAUAUCA
ENST000		NO:	UCUGAGAGGUAGUUAAUUUGGCACC
00437497-		895
95
ENSG000	1.578869575	SEQ	ACACUCAUUUUAGCCAGUGUCCAGGCUAUCAGCAG
00174429-		ID	AGAAAGACAGGUGGGCAGC
ENST000		NO:
00311955-		896
54
ENSG000	1.147621291	SEQ	GUUGCCAGGACGACGCCUGCGAAG
00174483-		ID
ENST000		NO:
00525809-		897
24
ENSG000	1.325274445	SEQ	ACUAUUGGGCGUUACGCGAGGGCGGGGCCGGUUGC
00174483-		ID	CAGGACGACGCCUGCGAAG
ENST000		NO:
00526760-		898
54
ENSG000	2.422909313	SEQ	AACGCGGUUACCGUGGAAACCGCGGCC
00174628-		ID
ENST000		NO:
00564186-		899
27
ENSG000	1.442627439	SEQ	CCCCUCGUCUCCUCCAAG
00174780-		ID
ENST000		NO:
00504757-		900
18
ENSG000	1.157674769	SEQ	AGUAGAAAAGUUUCUUUUCUUUGAAGUACAGAACU
00174837-		ID	ACAGCAUA
ENST000		NO:
00250572-		901
43
ENSG000	1.426691301	SEQ	UCUGCAGAGUGAGAGCAAACUAAAAGAGAAAAAUC
00174970-		ID	AAAGUUGACUACAAUA
ENST000		NO:
00312345-		902
51
ENSG000	1.096097895	SEQ	CUUUCCUCUCCUGACUAAGUUUCUCUGGCUUCCCUG
00175121-		ID	AGGCUGCAGGUGUUAAUCUGGGGGGCCCUGGGCCC
ENST000		NO:	UGAGCCGGCAGCAGAAAU
00372789-		903
89
ENSG000	1.190833023	SEQ	AGGUUCGAUACAAGAGGCUGUUUUCCUAGCGUGGC
00175387-		ID	UUGCUGCCUUUGGUAAGAAC
ENST000		NO:
00586040-		904
55
ENSG000	1.543381243	SEQ	AUUUGCCUCUGCAACUUGACUCUCCUCUAGGAAGA
00175787-		ID	GUACUCCAGAGAGCAGGGAU
ENST000		NO:
00480716-		905
55
ENSG000	1.640477609	SEQ	CUAUCUGACCACAUUGUUAAACUUGGUUAGUUUUG
00176009-		ID	CAGGUUAAAGAGGAA
ENST000		NO:
00531618-		906
50
ENSG000	1.239154308	SEQ	AUAGUAAAGGUCGGCCCGCGCAAG
00177034-		ID
ENST000		NO:
00512528-		907
24
ENSG000	1.46662933	SEQ	CCUCUUUAGUGC
00177103-		ID
ENST000		NO:
00527706-		908
12
ENSG000	1.10877424	SEQ	CCGAGCCCGAGCC
00177225-		ID
ENST000		NO:
00524550-		909
13
ENSG000	1.266570569	SEQ	ACUCUUGGAGGAAGGCAUCAGUUAAGGACACUGGA
00177669-		ID	AAAGACAGGCUCUUUUGUUCUGGUUCCUA
ENST000		NO:
00320542-		910
64
ENSG000	1.985642212	SEQ	GAAAGUUCUAUAGUCUCUAUAUUCUGUUAUCAAGU
00177684-		ID	CUUUCAACAACUUCUUUCUACAGA
ENST000		NO:
00322066-		911
59
ENSG000	1.449863416	SEQ	AGAAGGUCACAAAGCUUGCAGGGUAAGUGACACAA
00177694-		ID	CUUGAAACUGCUUGGCCCUCUUUAAAAAGAAAUAA
ENST000		NO:	UAAA
00454872-		912
74
ENSG000	1.295821214	SEQ	AAGUGAUUUGCUUAAAAUUUCUCACACAAAGCUAC
00177752-		ID	AUUUACUGGAGGAUCUUUCUAUAAAAAAUAAACAG
ENST000		NO:	AGG
00332990-		913
73
ENSG000	1.1016613	SEQ	UGGCCAGGCCCAGGAAAUCC
00178104-		ID
ENST000		NO:
00585156-		914
20
ENSG000	1.11417304	SEQ	ACAGAGAACCUCAGCUGGACAAAGCAGCCUUGAUC
00178172-		ID	UGAGUGAGCUAACUGACACA
ENST000		NO:
00325630-		915
55
ENSG000	2.126320054	SEQ	UCAUAUUUGUGCUCCUUCACGGGAGGGCAGGGAGG
00178287-		ID	UUCAACGGACCUUAAAAC
ENST000		NO:
00326625-		916
53
ENSG000	1.28415615	SEQ	UCUAGGUUUUCACAUCCUUUCUAGUAGUUUCGCCA
00178460-		ID	UCUAUAGCUUUUAUCAACAAUUGUGGUUUAAUCAA
ENST000		NO:	UUAGAAAUAUUAACCAGGAGAAA
00415737-		917
93
ENSG000	1.346267224	SEQ	AAUUUUAAUCUUCUUUUCUUAGAACUAUCUUGGUU
00178522-		ID	GGCAUCAUCAGGCCCUGAGAGCACAGUGC
ENST000		NO:
00449493-		918
64
ENSG000	1.452521093	SEQ	CCGCGAGCUUACACCGGCUUCUCUCUGUCCUCAGCC
00178741-		ID	CGCGCGCCGCCAUCGCCGUC
ENST000		NO:
00562233-		919
56
ENSG000	1.945486005	SEQ	GUGAGUUGCAGUUUGUGUGAGGAUCCCGGGGCCGC
00179262-		ID	CGCGUCGCUCGGGCCCCGCC
ENST000		NO:
00593114-		920
55
ENSG000	1.367184063	SEQ	UUGCCUUUAGGUUUUCCGAAGGUCAACA
00179626-		ID
ENST000		NO:
00394256-		921
28
ENSG000	1.238926188	SEQ	AUUUGUGACUUCUUCAGACCACUUUC
00179915-		ID
ENST000		NO:
00331040-		922
26
ENSG000	1.249845236	SEQ	AUUCUCUGCCUCUGAAGGCUCCAGAGGCUGUGGGA
00180287-		ID	AGCAGCACAUCAGCGACAGCUCCUGGCUGCUGGACU
ENST000		NO:	CCGCAGGGAGGGAAGGAAGAUUGGUCGCA
00314833-		923
100
ENSG000	1.105668147	SEQ	AAAAGUAAAACCAGUUGUUGUGGAGAAAUAAGAGG
00180336-		ID	ACCUGCUCCUCCAAUUUAAAGUCAGUUUGGCCA
ENST000		NO:
00432494-		924
68
ENSG000	1.452912777	SEQ	AUAGUUCUGCAGUCACAAGGGCUUUGUAGUCAGUC
00180347-		ID	UUAGCUGCUGGAACAUUCAAGGAGACAAAAAGGCA
ENST000		NO:	CAGAAGAUCUCCACACAUACUUUG
00451887-		925
94
ENSG000	1.104190423	SEQ	AGAGAGGGAGUCGGUGUGGACGCGAGGAGCCGGGC
00180353-		ID	GCUUAGAACAGAGGCUUGCACAGGUGGAG
ENST000		NO:
00464274-		926
64
ENSG000	1.334429401	SEQ	ACUGAAGCAGCAGCUCAGUUUCUCACUCCGAAGUG
00180353-		ID	GCAGCAGCCAGAGAGGGAGUCGGUGUGGACGCGAG
ENST000		NO:	GAGCCGGGCGCUUAGAACAGAGGCUUGCACAGGUG
00495491-		927	GAG
108
ENSG000	1.247964792	SEQ	AAAGCGGCCAGUUUUUACAUAUUUCUUGAUUUUGU
00180573-		ID	UUGUUUUCUCGUGAGCUUAGGCCGCUGGUUUUGGU
ENST000		NO:	GAUUUUUGUCUGAUUGCA
00314088-		928
88
ENSG000	1.296417677	SEQ	GAUUUUGUUUGUUUUCUCGUGAGCUUAGGCCGCUG
00180573-		ID	GUUUUGGUGAUUUUUGUCUGAUUGCA
ENST000		NO:
00377791-		929
61
ENSG000	1.693230226	SEQ	CUUGGACCAAUCAGCCUUGUGUUUAUAGGAAUUAU
00180773-		ID	UUCUGUUCACUGU
ENST000		NO:
00534116-		930
48
ENSG000	1.480900202	SEQ	AACAACAGCUGAGUCAGACAGAGUAUCUGUACACU
00180872-		ID	GUUUUAUACCAAGAAAUCAUUUACA
ENST000		NO:
00651554-		931
60
ENSG000	1.872737891	SEQ	ACAGGCAGUAACCACGAGUCUCAGCCCCUUAGCUGA
00180919-		ID	ACUUUUAAACAGAGAUUUCUUCUAUUUCAGACAGA
ENST000		NO:	CACUGAGACUGAGGCACCCAUUCC
00316529-		932
95
ENSG000	1.282665562	SEQ	UUCUCUUCAGGAGUAAACUUCUGGAAAAAUAGA
00181009-		ID
ENST000		NO:
00317093-		933
33
ENSG000	1.205743985	SEQ	UUCUGUGGUGGUUCCAACCUGUGAUAACUGAGAAC
00181023-		ID	AAUACAAAUAGAGAUUUGAAAUUCAGUUUGAAUC
ENST000		NO:
00317121-		934
69
ENSG000	1.376599392	SEQ	CUUGUACCUGUCGUUCGCAGUGGCUCACUUUCCCAA
00181322-		ID	GCC
ENST000		NO:
00484930-		935
39
ENSG000	1.30411828	SEQ	CCCUCUGUCUUUAGGGGCUGAGAUUUAGUCCAUCU
00181616-		ID	GCCUCUGCC
ENST000		NO:
00641796-		936
44
ENSG000	1.341404417	SEQ	AGUCACUUGCCAUUUCUCAUAACAGCGUCAGAGAG
00181617-		ID	AAAGAACUGACUGAAACGUUUGAG
ENST000		NO:
00317987-		937
59
ENSG000	1.219852565	SEQ	UCUCAGCAGUUUAAAGCAAUUGAACAUC
00181693-		ID
ENST000		NO:
00313022-		938
28
ENSG000	1.197577581	SEQ	UGUUGAUAGCCCAUUGUGCAAAAUAAGUGAUAAAA
00181785-		ID	UUCAAAGUUCUUGAGUGUGCUGAGGUCCAGUGGGA
ENST000		NO:	AAAACAAGAAAACUAAG
00641320-		939
87
ENSG000	1.644675067	SEQ	AAGAAAGUGGGUCAGCAGGAGUUCCAGCAUCUCAG
00181904-		ID	AAUUGUGGUGAAAACCAAUACAAAAA
ENST000		NO:
00338051-		940
61
ENSG000	1.591939527	SEQ	UUCUUUUUUUAACGUUUCCACUUUUAGUAUUAUUU
00182004-		ID	CAGAGAUCGCGGAUUCAGGUGUGGCUCUAGUAGCA
ENST000		NO:	AGUGAAU
00367208-		941
77
ENSG000	1.643557117	SEQ	CUUUAUUCCGGAAGUUGCUCUCAGAGGCAGCGUGC
00182004-		ID	GGGUGUGCUCUUUGUGAAAUUCCACC
ENST000		NO:
00414487-		942
61
ENSG000	1.769986651	SEQ	GCACUCGACGGCUGACUGGAGCAGCGGAUAUAAGU
00182134-		ID	CAAAGAGUACAGCAGAAA
ENST000		NO:
00526413-		943
53
ENSG000	1.362800917	SEQ	GUACAGGUUAUUUCAUUUCUGGCUGCAGUUUUGCA
00182150-		ID	UAAAAAGGGAACUCGUGAGGAUAUUGAAAAUAAC
ENST000		NO:
00402838-		944
69
ENSG000	1.206313264	SEQ	CUUUUCUUUGCUGGAUCUGGAGGC
00182185-		ID
ENST000		NO:
00553334-		945
24
ENSG000	1.302329302	SEQ	GAGUAGUUCUACCAUUCUCUUUUGAGUCAUAUAGA
00182287-		ID	GAGUGCGCAAGUUAUAGCACAG
ENST000		NO:
00673445-		946
57
ENSG000	1.162249211	SEQ	AAAAUACUAACCAGCCAGAGAAACAGAAUCCUAAC
00182333-		ID	UAUUUCUGAGGAAACUGCAGGUCCAAA
ENST000		NO:
00608620-		947
62
ENSG000	1.163065949	SEQ	UUAUUAGCAAGCAGCAAAU
00182504-		ID
ENST000		NO:
00465011-		948
19
ENSG000	1.256476998	SEQ	UAUUAACAAAAUCAGUUAAGCAGUAGAAAGGUGGG
00182568-		ID	UUCUUCUGAAGAUAAAGUGAACC
ENST000		NO:
00475083-		949
58
ENSG000	1.501244068	SEQ	CUGCGGAAGUUCAACUAUUCAAC
00182628-		ID
ENST000		NO:
00330137-		950
23
ENSG000	1.428481425	SEQ	AAAACACUGACUAGUAAGGAGGAAGACAUUGAAGA
00182732-		ID	AGGAAAGCCAUCUAUCUCUGUAAGAGGACA
ENST000		NO:
00554782-		951
65
ENSG000	1.28907986	SEQ	ACUGAUAUAAAUCUGCUUAGGAGGCCUGAUUCACA
00182853-		ID	GACGCUACAGG
ENST000		NO:
00416307-		952
46
ENSG000	1.372846253	SEQ	ACUCGCUUUCCUCGGAUUCCCGGAGUUGGGGGAUU
00182923-		ID	UUUGACAUCUUGUGAAGCAGAACUACAGGAGCUC
ENST000		NO:
00684170-		953
69
ENSG000	2.763412453	SEQ	AAGGAGAGAAA
00182944-		ID
ENST000		NO:
00332035-		954
11
ENSG000	1.101929967	SEQ	AGAGGGAAAGCGAGAGGGAGACGGACGUUGAGAGA
00182944-		ID	ACGAGGAGGAAGGAGAGAAA
ENST000		NO:
00437155-		955
55
ENSG000	1.664718743	SEQ	AACAUUACCAGUUUCAACUUACUAGUCUCAAGUCC
00183035-		ID	AGGCAACGUACAGGCAGGGGAA
ENST000		NO:
00621735-		956
57
ENSG000	1.208273829	SEQ	AGCAAGGUUCCUUGGAAGAAG
00183077-		ID
ENST000		NO:
00586731-		957
21
ENSG000	1.194329717	SEQ	AAUUGGUUUAGUAUCUGUAUAGUGGCAAUACUCUG
00183230-		ID	UCCUGCAGUAGGCAGC
ENST000		NO:
00683624-		958
51
ENSG000	1.178516795	SEQ	ACAAACCGGACCCGCAACCACC
00183283-		ID
ENST000		NO:
00604900-		959
22
ENSG000	1.240103799	SEQ	CAUUGUGGCUGGCAUAGUAUACAUACUUGGUUAAA
00183389-		ID	UAUAAGGGAGG
ENST000		NO:
00330728-		960
46
ENSG000	1.176566889	SEQ	AAUAGCAGCAGUACAGCCUUCUGAAUUUGGUACAC
00183389-		ID	UGGGUCUCCAGAUUGAUCAGGAAACUUUAC
ENST000		NO:
00641835-		961
65
ENSG000	1.372175066	SEQ	AGGCUGACAGAGAAAUUUUUCAUUUUCUUUCUUGU
00183395-		ID	UUGACUGUAGUCAAACAUCAAACUAAGA
ENST000		NO:
00329406-		962
63
ENSG000	1.204264954	SEQ	UCAUUUCCAUCAAGUGUGCAGCAGUGGUCUCUCUG
00183560-		ID	UAGCAGGCC
ENST000		NO:
00440961-		963
44
ENSG000	1.155796664	SEQ	ACCACUGGUCUUCUUGUGCUUAUCCGGGCAAGAAC
00183625-		ID	UUAUCGAAAUACAAUAGAAGUUUUUACUUAGAAGA
ENST000		NO:	GAUUUUCAGGGAGAAGUGAA
00395940-		964
90
ENSG000	1.511096092	SEQ	GAGAGACUACAACUCCCAGUAGUCACCGCG
00183632-		ID
ENST000		NO:
00569420-		965
30
ENSG000	1.432209209	SEQ	UAUAACAAGAGGAUUGCCUGAUCCAGCCAAG
00183735-		ID
ENST000		NO:
00676469-		966
31
ENSG000	1.213968303	SEQ	CAAACAGGGACA
00183765-		ID
ENST000		NO:
00464581-		967
12
ENSG000	1.382016145	SEQ	ACUUGCCGAAGC
00183853-		ID
ENST000		NO:
00368172-		968
12
ENSG000	1.400768934	SEQ	CUGGCAGAUAAGUGCUCUGGUUGUACAGUGAGG
00183862-		ID
ENST000		NO:
00329903-		969
33
ENSG000	1.194208509	SEQ	AGAUCGUCGCCUAUCCUGCUUGCGCAGCCGCUAUCG
00184083-		ID	CGUCUGCCCACCGACGAAGC
ENST000		NO:
00375180-		970
56
ENSG000	1.348401227	SEQ	CUGCAUUUUGUGAUCCUCUAUUUCAACACUGGUCC
00184140-		ID	AGUUAGCAGUAGAGUUGUCACAGCCGACAGAGGCA
ENST000		NO:
00328882-		971
70
ENSG000	1.669547111	SEQ	UGCUGGGAUUACAGGCGUGAGCCACCGCGUCUGGCC
00184209-		ID	UCAGCCAAGGUUUUUAAGUAACAUAUUUCAGCAUU
ENST000		NO:	GGCUCUACAGCGUUGCAGAAC
00350887-		972
92
ENSG000	1.921123475	SEQ	ACACAUCUCACUCAUCCUUCUACUCGUGACACUUCC
00184330-		ID	CAGUUCUGGCUUUUUGAAAGCAAAG
ENST000		NO:
00368729-		973
61
ENSG000	2.014335888	SEQ	AACGCAAAACCUGCUCUUUAGAUUUCGAGCUUAUU
00184357-		ID	CUCUUCUAGCAGUUUCUUGCCACC
ENST000		NO:
00331442-		974
59
ENSG000	1.120565441	SEQ	CUUUCCCGGAGGCUGGCAG
00184428-		ID
ENST000		NO:
00329245-		975
19
ENSG000	1.797996465	SEQ	AUACGAGUUACUUUUUUUAAGUCCGUUGAAACAGA
00184434-		ID	GUUAAUUUCCUUUAGCACACAAGUCUUAGAGACAA
ENST000		NO:	AAGAAAAAAAGGUCUGCAAC
00380055-		976
90
ENSG000	1.09960343	SEQ	AGAAACCUGUGUAGCCAGAG
00184451-		ID
ENST000		NO:
00332438-		977
20
ENSG000	1.196399177	SEQ	CUGAGCGCAGUUGGAGUUCGGAGGAAAAGGGCUCA
00184465-		ID	GAUUGAAG
ENST000		NO:
00423258-		978
43
ENSG000	1.462206433	SEQ	AGGACACAUUUAGUCAGAGUAGCUUAUAAGAGACC
00184588-		ID	GUUCCCUCCGCCUUCUUCCUCAGAGGAAGUUUCUUG
ENST000		NO:	AAGAAUCUUAUCAAAAAUUAGCA
00526197-		979
94
ENSG000	1.854117048	SEQ	AGAAGGAUCCAUCUAACAUUUACUGAAAUAAGGAA
00184613-		ID	GAGUCUUUAUUCAAUCUAAAAGUGAAAAAAGAACC
ENST000		NO:	UUUUAGACAUUAUUAUUAUAAA
00333837-		980
92
ENSG000	1.343693352	SEQ	CUGUGUCUUACC
00184678-		ID
ENST000		NO:
00369155-		981
12
ENSG000	1.456029376	SEQ	ACUCGGCCUAGGAAUUUCCCUUAUCUCCUUCGCAGU
00184697-		ID	GCAGCUCCUUCAACCUCGCC
ENST000		NO:
00328796-		982
56
ENSG000	1.646705337	SEQ	ACCUGCCCAGUGCCACUUCCUUCUCUCUGUCCCUGU
00184925-		ID	GGGCCCAGCAGCUGCCAGG
ENST000		NO:
00371633-		983
55
ENSG000	1.559106462	SEQ	UUUUGCUCUCUGGGAUUGGUUUCUUAAAGAAUCUG
00185008-		ID	GAUCCUUUUUAAUAGUUCAAA
ENST000		NO:
00332191-		984
56
ENSG000	1.126932167	SEQ	GAGAAAGUUGUCUGCGUCUCGAGGCGAGUUGGCGG
00185043-		ID	AGCUGUGCGCGCGGCGGGGCG
ENST000		NO:
00328649-		985
56
ENSG000	1.497642295	SEQ	AUCCCUCUCAGCUCUUGCUAAGUGAUCACUAGCUUG
00185069-		ID	CCUCCAAGCUCUCUCACU
ENST000		NO:
00332411-		986
54
ENSG000	1.360169832	SEQ	UUGGUUUUGCCACUAUUGUUUCAUU
00185130-		ID
ENST000		NO:
00377401-		987
25
ENSG000	1.105239705	SEQ	AUCUGUUUUUUUCCCUUCUGAGCA
00185432-		ID
ENST000		NO:
00332160-		988
24
ENSG000	1.59079098	SEQ	UGCAAUUAAAGGAGUCGGGUCUCUAACUGUUGAUC
00185432-		ID	UGUUUUUUUCCCUUCUGAGCA
ENST000		NO:
00547104-		989
56
ENSG000	1.313763959	SEQ	ACAUUUAAGAAAUACAUUGGUUCAGUCCAGAAAGG
00185432-		ID	CAGGACAACCCGACGCGAGGCAGGGAGCUUCCAGGU
ENST000		NO:	UAUAGCA
00550502-		990
78
ENSG000	1.131954047	SEQ	CCCCCGGCAGCCCGGAGGAGC
00185532-		ID
ENST000		NO:
00373976-		991
21
ENSG000	1.468037556	SEQ	CCCCGCCUGAUCCGUGUCCGAC
00185624-		ID
ENST000		NO:
00680226-		992
22
ENSG000	1.51099076	SEQ	CUUCCUGCUGUC
00185627-		ID
ENST000		NO:
00382671-		993
12
ENSG000	1.703911723	SEQ	AAAAGUAGUCUACCCUGAAGACCCCAGAUUUUUGA
00185737-		ID	UCUGCUCUUUUGAGUCAGUUGAUAGAAUA
ENST000		NO:
00602794-		994
64
ENSG000	1.478052558	SEQ	ACACCUCAGUUCACAAUCCUGGGGCGAU
00185792-		ID
ENST000		NO:
00332836-		995
28
ENSG000	1.519311248	SEQ	UUAAAGUACUUGGAGUUUUUAUAGGUUGGCACUCA
00185864-		ID	UCAGUAGCCCCUGUUCUCAUUCUGCAA
ENST000		NO:
00529969-		996
62
ENSG000	1.387501218	SEQ	AUUUCAAGGAUUCUACCAUCAGAAAAGAGGCCAAA
00186007-		ID	CUUCUAUCAUC
ENST000		NO:
00367149-		997
46
ENSG000	1.385222169	SEQ	CCCAGAUCUCUUCAGUUUUUAGUCCUCAUUCUGUG
00186092-		ID	AAAAUUGCUGUAGUCUCUUCCAGUU
ENST000		NO:
00641515-		998
60
ENSG000	1.245881817	SEQ	ACUGUGCUGGGGUGUACAUCUACACUAGACACCUU
00186335-		ID	CCUGCUUCCCUCCUUCCAGAGCAGACCUCUUUGUCA
ENST000		NO:	CCCCGAGCUCCUUGUUUCUUAAGCAGUC
00335244-		999
99
ENSG000	1.18259916	SEQ	GUUUUUCUCUCUGCUUUCUCAACAGCCAGAUCUGCC
00186469-		ID	AGUGAGCCUCAGGCUUUAGGAACUGAAGAGUGUUU
ENST000		NO:	CUGAAAGAUCUAUCCAGCACUCCG
00556752-		1000
95
ENSG000	1.103341541	SEQ	UCAGGGCAGUAGAACAUAUUUUAAUCAAGUCCCCU
00186572-		ID	UGAUAAAAGAGCUUGAUUCCAGCUACUGCACUUCC
ENST000		NO:	UUCAUCAGCUCUCCACUG
00335021-		1001
88
ENSG000	1.998127013	SEQ	CCUUGCCAGUCCUUCAGAGCCAUUGUAGCAGGAGGC
00186635-		ID	AGAGUACAGAGUG
ENST000		NO:
00455638-		1002
49
ENSG000	1.135427481	SEQ	GGCUUUGGGAAGAUCUAAAGACCCAGGAAGGUCUC
00186652-		ID	UGGGUGGGAUAAAGCCAAG
ENST000		NO:
00533605-		1003
54
ENSG000	1.450039966	SEQ	CAAGGUUAUCCAUCUCAAGUAGCCUAGCAAUAUUU
00186803-		ID	GCAACAUCCCA
ENST000		NO:
00357374-		1004
46
ENSG000	1.129244458	SEQ	CUGCUAUACAACUGAGCCUACCUUUCUUGAAACC
00186924-		ID
ENST000		NO:
00334680-		1005
34
ENSG000	1.466846422	SEQ	AGAAUCUUCUUAGGUACACUCAGCUGAACUCCCAUC
00186971-		ID	UCUCAUCAGC
ENST000		NO:
00334068-		1006
46
ENSG000	1.14098428	SEQ	AAGUGGGGCAGC
00187024-		ID
ENST000		NO:
00416214-		1007
12
ENSG000	1.538600768	SEQ	AGUCACACUUCAGAAAUAUCCUCCUACACCUCAACU
00187026-		ID	GAAAUCUAACCUCCUGAAAUC
ENST000		NO:
00333892-		1008
57
ENSG000	1.102818675	SEQ	CUUUGCCAGUCCAUCUUCAAAUUGGAAUUAUAGAA
00187098-		ID	AGUAGAGGGAGGGAUAGUCUACCGUCUCUCACUGG
ENST000		NO:	AUUGGUGCCACCUAAAACAUUGUU
00394348-		1009
94
ENSG000	1.247153321	SEQ	UCUUUGCCAGUCCAUCUUCAAAUUGGAAUUAUAGA
00187098-		ID	AAGUAGAGGGAGGGAUAGUCUACCGUCUCUCACUG
ENST000		NO:	GAUUGGUGCCACCUAAAACAUUGUU
00478490-		1010
95
ENSG000	1.906298135	SEQ	AGAACCAGUAAGCAAAUUAAGUGUAUCGAUUGCAA
00187391-		ID	UUUUGUUGGACUAACCCUGCUUUUUUUUUCUUAAG
ENST000		NO:	GAAUAAACUUGAUUCCUUUUAGU
00636178-		1011
93
ENSG000	1.346087887	SEQ	AGUCUUUUCGCUGGUUAUUACAUCUUGCGUUUCUC
00187475-		ID	UGUUGUU
ENST000		NO:
00338379-		1012
42
ENSG000	1.286957338	SEQ	GCUGUCUGUGUCUUCAGGUCAUC
00187492-		ID
ENST000		NO:
00343366-		1013
23
ENSG000	1.262401764	SEQ	AUUUGUGACUUGUCUC
00187627-		ID
ENST000		NO:
00409776-		1014
16
ENSG000	1.35268997	SEQ	ACCAGUUCGCGCUCUCCUCCGGCAGAAGUAGCAGCU
00187690-		ID	GCGCUCUUGCUCUCUGGGGGAGAACCUGGCGUU
ENST000		NO:
00342995-		1015
69
ENSG000	1.512590793	SEQ	UGAACAAUUGCAGUUACUACCUUAGUUCUGUAAGG
00187701-		ID	UUUCUCUCUAAAUAUUCAGAUCAUCGUGUUUGGGG
ENST000		NO:	AAGAUACUGUGUAAGAGCU
00460972-		1016
89
ENSG000	1.933200485	SEQ	AAAAGUUGCUUCUUACAGGAAUAUAAAUAGUUUCU
00187733-		ID	GGAAAGGACACUGACAACUUCAAAGCAAA
ENST000		NO:
00370079-		1017
64
ENSG000	2.222280021	SEQ	AGCCGCCGCCGGGGCUGUAGGCGCCAAGGCC
00187741-		ID
ENST000		NO:
00568369-		1018
31
ENSG000	1.302585382	SEQ	GGAAUUAGAGAAUAAAAUCCCAGCACG
00187753-		ID
ENST000		NO:
00613665-		1019
27
ENSG000	1.586904311	SEQ	GUGCGAAGGAAACCGAGUGGGAUCGGAACCGUAGC
00187790-		ID	GGUUGAGCUGCUGCUGCUACGGAUAUCUGACAGAA
ENST000		NO:	GCCUUCGGUGGUUGUCGGCCUA
00556036-		1020
92
ENSG000	1.130407808	SEQ	ACUAGGCUCUCAGCCAGGG
00188038-		ID
ENST000		NO:
00339176-		1021
19
ENSG000	1.178508086	SEQ	UGCAGUCCUGUCUCGUUUCCCUCUUUCUCUCUCUCU
00188269-		ID	CUCUGAUAGUCACUUCAAUCAA
ENST000		NO:
00594432-		1022
58
ENSG000	1.114829554	SEQ	ACUUCUGCAGCACAGCUCCCUUCCCAGGACGUGAAA
00188373-		ID	AUCUGCCUUCUCACC
ENST000		NO:
00372126-		1023
51
ENSG000	1.136596257	SEQ	AGAGAACCUGGAGCCUAAGGUUUAGGCUCACCCAU
00188379-		ID	UUCAACCAGUCUAGCAGCAUCUGCAACAUCUACA
ENST000		NO:
00380206-		1024
69
ENSG000	1.171829026	SEQ	AAUCCUCCUCUUCUCCCUUCCUGAAGCUGCACGCUG
00188467-		ID	CAGUAAGAGCACAGCAGAA
ENST000		NO:
00341459-		1025
55
ENSG000	1.245989307	SEQ	UGCAGUAAGAGCACAGCAGAA
00188467-		ID
ENST000		NO:
00449382-		1026
21
ENSG000	1.437532998	SEQ	UAAUUAUUGAGUGCUCUGCCUGCUUAGGACUCUGC
00188629-		ID	CCAGCCAGGAAGGAAACCUACAGGAGGAAGA
ENST000		NO:
00589262-		1027
66
ENSG000	1.958972325	SEQ	GUUUUCUUAGUAUAGUUCAUUCUCAAUAAUAUUUC
00188649-		ID	UUAUUUAUUUAGAAAGUUGAAAUAAAAGGACCAUC
ENST000		NO:
00636965-		1028
70
ENSG000	1.385334897	SEQ	ACUUUGCUGAUUUAGCUUAGUGAAGAGGAACCAGA
00188820-		ID	AAUUUGUCCUUGAAUA
ENST000		NO:
00368606-		1029
51
ENSG000	1.117127511	SEQ	AGUGAACUUCUGAUAGGGUCUUAUUU
00188992-		ID
ENST000		NO:
00344577-		1030
26
ENSG000	1.186798237	SEQ	CCUUUUUGGUGAAUUGAGUGCUGUUUUUGCUUUUC
00188992-		ID	UCAGAUUCCAA
ENST000		NO:
00536861-		1031
46
ENSG000	1.097273628	SEQ	AAGACAGGCAUCUCAAAUCGGCUGAUUCUGCAUCU
00189058-		ID	GGAAACUGCCUUCAUCUUGAAAGAAAAGCUCCAGG
ENST000		NO:	UCCCUUCUCCAGCCACCCAGCCCCAAG
00343267-		1032
97
ENSG000	1.214331453	SEQ	AUUCUCUGGAGUUUGA
00189144-		ID
ENST000		NO:
00489148-		1033
16
ENSG000	1.223880777	SEQ	UCAGAUCACAGAUUUCCCUGCCAA
00189181-		ID
ENST000		NO:
00342623-		1034
24
ENSG000	1.185393876	SEQ	CUGCUCAGCACUAGGCCGGCAGAAUCUGAGCG
00189430-		ID
ENST000		NO:
00598576-		1035
32
ENSG000	1.520503024	SEQ	AACACUCACAAGAGAGCAGAGGAGCCCCAAGUCUU
00196209-		ID	GGGGACCACAGAAGAGUCC
ENST000		NO:
00608073-		1036
54
ENSG000	1.988764021	SEQ	AGAAGGGUACAAAUCUUUUUUCUUUCUCCAAGGAG
00196353-		ID	AAUCUUUUGAGCACAAGUA
ENST000		NO:
00505881-		1037
54
ENSG000	1.279951085	SEQ	CUGAGUCACAUUGAGGUCUCUUGCUUUAGGAACUG
00196391-		ID	AGUACGCUUGAUA
ENST000		NO:
00558586-		1038
48
ENSG000	1.856926054	SEQ	ACACUCGCUUCUGGAACGUCUGAGGUUAUCAAUAA
00196565-		ID	GCUCCUAGUCCAGACGCC
ENST000		NO:
00336906-		1039
53
ENSG000	1.143503127	SEQ	GCAUUAUCCACUAGAUACGUCGAAGAAGAGGGAAA
00196628-		ID	CCAAUUAGGGUCGAAAUAA
ENST000		NO:
00568147-		1040
54
ENSG000	1.121501726	SEQ	GAAAAGUCAACUGAAGGAAUUGUUGUGAAAAAAGG
00196628-		ID	GACAGCGAGUUUGAAAUAAAAGUUGUUAGAGUGGU
ENST000		NO:	ACUGAGGAGAAAAAAGAAUCCGAGACC
00628689-		1041
97
ENSG000	1.233556294	SEQ	AUUGGAAGUACAGUUUUUGGAAGUGUGGAGCAGUU
00196628-		ID	UGGCUAAGAAUAGGA
ENST000		NO:
00630828-		1042
50
ENSG000	1.128029078	SEQ	ACGGCCGUCGCC
00196683-		ID
ENST000		NO:
00372879-		1043
12
ENSG000	1.447781298	SEQ	UGGAUACACUGGAAAAAGUUCUUGCUGGGCAACCA
00196712-		ID	AAGGACACAAGUAGAUUAG
ENST000		NO:
00490416-		1044
54
ENSG000	1.670486941	SEQ	ACAAGAGAACAACUUGCUCCUUCCACAGGAAGCUGC
00196844-		ID	ACCUGACAGAAGCUCCAGG
ENST000		NO:
00358524-		1045
55
ENSG000	1.178078321	SEQ	CUGUUUGGAGAGACUCAGCCAUC
00196890-		ID
ENST000		NO:
00620438-		1046
23
ENSG000	1.113116982	SEQ	GGGAGACUGGAGUCGAAGGCCGUGAGGUAUUUUUC
00197223-		ID	UAAGUCAGCCAUA
ENST000		NO:
00355848-		1047
48
ENSG000	1.173655751	SEQ	ACAAAGCGUUGGGUGAGACUCCUCUUGCUCGUC
00197238-		ID
ENST000		NO:
00355057-		1048
33
ENSG000	1.178970809	SEQ	CAAGGCAUUCUUCCAGUUCCUCAGCCUCCUCUUUCC
00197309-		ID	UUCCUAGGACUGGCUUCC
ENST000		NO:
00318666-		1049
54
ENSG000	1.116606471	SEQ	UCCUUGCACAAGAGGAAGUAUAUCCAAUUCUUGCC
00197309-		ID	AGGCAUUGAGACUGGCUUCC
ENST000		NO:
00641546-		1050
55
ENSG000	1.142287306	SEQ	CCUUUCUCUCCUCUGAGCCACAACUAAAGUAGUUUU
00197428-		ID	CUACUUUUCCCUUUCUACUUUCCUAGACCCUGGAUU
ENST000		NO:	UUGU
00357605-		1051
76
ENSG000	1.117052404	SEQ	GUCUUUGGUAGUUUUUUUGCACUAACUUCAGGAGC
00197465-		ID	CAGCUCGUGAUCUCAGG
ENST000		NO:
00358615-		1052
52
ENSG000	1.225835677	SEQ	AGUGGCAAGCGCGGGCAGGACCGCGUUGCGUCAUC
00197548-		ID	GGGGCGCGCGCCUCAGAGAGAGCUGUGGUUGCCGG
ENST000		NO:	AAGUUGAGCGGCGGCAAGAAAUA
00451830-		1053
93
ENSG000	1.428994846	SEQ	CUCAAAACUGCCAGUGUGAGAGGAUUUGGAAAUCA
00197580-		ID	CUGGAUCUGCUCAAUACAAAA
ENST000		NO:
00527939-		1054
56
ENSG000	1.237656909	SEQ	ACUGUUUAGUAGUACUCAAAACUGCCAGUGUGAGA
00197580-		ID	GGAUUUGGAAAUCACUGGAUCUGCUCAAUACAAAA
ENST000		NO:
00531003-		1055
70
ENSG000	2.54485032	SEQ	GUGAAUAUUAGUCAUCAUUUAUAUUUUAUUACUAU
00197603-		ID	UAUUGUUUACAGAAUCUUGGGACUGUUUUACUUAA
ENST000		NO:	UUGGUCAUUGAUAGCUUAACAAAC
00508244-		1056
94
ENSG000	1.326741738	SEQ	ACAGUGAUAUCCUGAGAGAAG
00197885-		ID
ENST000		NO:
00614374-		1057
21
ENSG000	1.368717994	SEQ	AGAGAACCUAGAGCCCAAGGUUCAGAGUCACCCAUC
00197919-		ID	UCAGCAAGCCCAGAAGUAUCUGCAAUAUCUACG
ENST000		NO:
00276927-		1058
69
ENSG000	1.21685797	SEQ	CCUUCGCGGCGCUUCCUAGUUCGGCUGGUUCUUCUG
00198001-		ID	UCGCCGGCUUCAGCAGCCCGCGCCCGGGCAGGAAUA
ENST000		NO:	GAAG
00550615-		1059
76
ENSG000	1.568821266	SEQ	AAGCAGAUUCUAAAAGCAGUUUCUCUUCAGAACAU
00198015-		ID	CUUUUUUCAUACCACUUGAUAAGCAUCUUGAAACA
ENST000		NO:	CC
00548545-		1060
72
ENSG000	1.252271504	SEQ	GUUGAGGUCAAGUAGUAGCGUUGGGCUGCGGCAGC
00198033-		ID	GGAGGAGCUCAAC
ENST000		NO:
00618094-		1061
48
ENSG000	1.400423915	SEQ	CUUACCGUGGCGAGUUCCGCGCUCA
00198056-		ID
ENST000		NO:
00338193-		1062
25
ENSG000	1.159667994	SEQ	GGUAGACGCGAUCUGCUGGCUACUACCGGCCUUCCC
00198062-		ID	UGGCUGUUAAAAGCAG
ENST000		NO:
00343518-		1063
52
ENSG000	1.519311248	SEQ	UUAAAGUACUUGGAGUUUUUAUAGGUUGGCACUCA
00198064-		ID	UCAGUAGCCCCUGUUCUCAUUCUGCAA
ENST000		NO:
00564219-		1064
62
ENSG000	1.243385767	SEQ	AGACUGGUCUUCUGAGGACCUCUGCCCUCUACACAG
00198131-		ID	CGGCCUCUUCAGGUGCAGGGAGGAA
ENST000		NO:
00269829-		1065
61
ENSG000	1.364844039	SEQ	GAAAACUCAUUUGCUCUUGGAGCAGUCAGGCAGUG
00198157-		ID	ACUGCCUUCGGCUUUUUUUCUGCUGACUAAGAUCU
ENST000		NO:	CCUAUAGAGAGCUACAACA
00373250-		1066
89
ENSG000	1.287988673	SEQ	UUCUCUCUGACCAGCACC
00198223-		ID
ENST000		NO:
00381500-		1067
18
ENSG000	1.136884293	SEQ	GUCAUUGGCACC
00198231-		ID
ENST000		NO:
00578137-		1068
12
ENSG000	1.327651757	SEQ	AUUGGAGACCCUUUUCACAAG
00198242-		ID
ENST000		NO:
00422514-		1069
21
ENSG000	1.212784343	SEQ	CUAAAACCUGCCAGCAGUACUUUUGAGUUUUUUUU
00198363-		ID	UUUGUUUUGUUUUACUUUAGCAUUUAUUAUUCAGU
ENST000		NO:	GAUUGAAGAAAUCAAA
00389204-		1070
86
ENSG000	1.295356884	SEQ	AGUCAAACUCAGAAUCUUCUCAGUGUAACUCAGCU
00198390-		ID	GAACUCACAUCUCCCAUCAAC
ENST000		NO:
00355459-		1071
56
ENSG000	1.262455064	SEQ	AGCAUAACUUAUAGAGAAGCUAGUAAGUUCUGAGA
00198398-		ID	AAGAAGGAAAUAAACACAGGCACCAAACCACUAUC
ENST000		NO:	CUAAGUUGACUGUCCUUUAAAU
00354905-		1072
92
ENSG000	1.447695994	SEQ	ACAUUCGAAAAACUCACUGUCUUGGAAACCUACCU
00198443-		ID	AGAACCUCCACCCUCUGACACC
ENST000		NO:
00398472-		1073
57
ENSG000	1.285407624	SEQ	CUUUCAAAGAGACAUAUUAGUCAAGGAAGCAACUC
00198633-		ID	GGAAGAGGAAAGAAAGGAAGUCAGGA
ENST000		NO:
00332323-		1074
61
ENSG000	1.357838037	SEQ	UCUUUUCUGCCGGGUA
00198839-		ID
ENST000		NO:
00450657-		1075
16
ENSG000	1.200607499	SEQ	CCCAGGCAGACUGAGGAGUCCCUGUGUUUUUGGCA
00203757-		ID	AAGGUAGCUCUACUAGAAAU
ENST000		NO:
00368145-		1076
55
ENSG000	1.220477114	SEQ	ACAUUGCCAGCAUCUUCUCUCCUCACUCACCCUUCC
00203782-		ID	UGGUGCUUUGGGCUCUCCUUCCUUCUCAGACAAG
ENST000		NO:
00368742-		1077
70
ENSG000	1.211073127	SEQ	UAAACUCCUGGUACUUGAGCACUGAUCUGCUUUGG
00203785-		ID	AGAACCUGAUUCUGAGACUCCAGCAGG
ENST000		NO:
00368750-		1078
62
ENSG000	1.255133038	SEQ	AUAGGAAUUUAGUGAUUGACA
00203963-		ID
ENST000		NO:
00371006-		1079
21
ENSG000	1.172272144	SEQ	ACAGUGCUCAUUGUGCCUGCGCUGCCAGCAGCCAGG
00204161-		ID	AGCCAGGAGCCAAGAGCAGAGCGCCAGCAGUAACU
ENST000		NO:	UGGGGGUCAGC
00374151-		1080
82
ENSG000	1.094469431	SEQ	CUGGAAGGAAGCAGG
00204305-		ID
ENST000		NO:
00375056-		1081
15
ENSG000	1.241533366	SEQ	AAUCAAGGAGAGUCUCUGGACACUAUAAUUCCUGU
00204361-		ID	GAGAACACGAGAAG
ENST000		NO:
00389586-		1082
49
ENSG000	1.226415559	SEQ	AUUCAGUUGGCCACUGCUGAGCAGCUGAGAAGGUG
00204516-		ID	GCGACGUAGGGGCC
ENST000		NO:
00252229-		1083
49
ENSG000	1.803398624	SEQ	AUAAACAAACAUUGAUUGCUUUCCUAUCUUACAUU
00204703-		ID	UUUUUAGGAGUGCGAAAUAAGUGAGUCAUC
ENST000		NO:
00377173-		1084
65
ENSG000	1.217365165	SEQ	ACGAGUUCUUCCGGGGCGGAGGUCACC
00204822-		ID
ENST000		NO:
00409710-		1085
27
ENSG000	1.181049777	SEQ	AGAUUUUGGGAAACUCACCUCUUAACAGAAGCCCA
00204873-		ID	CCCUCCAUCCCUGACACC
ENST000		NO:
00411528-		1086
53
ENSG000	1.302969659	SEQ	AGAAGGCACUCCAUUCUGGCUUUCACAAAUACAGC
00204897-		ID	UCUGCAACGCGUUUGCCCUGAUACC
ENST000		NO:
00312150-		1087
60
ENSG000	2.012761787	SEQ	CACACUCUGCCUUUGGACGUGAGAGAGAGCGCACCU
00205097-		ID	UUCACUUGAGCUUCAAC
ENST000		NO:
00378763-		1088
53
ENSG000	1.327723269	SEQ	ACCAGAACCCUGAAUUCCGAGAUAGAGGGAGUGUU
00205108-		ID	GAUCUCAGUCUAAGUAAGUUUAGACC
ENST000		NO:
00378788-		1089
61
ENSG000	1.616305036	SEQ	GUGCAGCAUUGUACUGCAAGUCAAUCGAUACAAUA
00205111-		ID	AUUUAAGUCACUUCAGCUAUA
ENST000		NO:
00419111-		1090
56
ENSG000	1.138413812	SEQ	AUAACUCAGCCUCUCCAGAGUGCAGCCACCAGUACC
00205279-		ID	UCCGCAGAUUGAGUAGUGAAGAAAAGAAAACCAGG
ENST000		NO:	AUAUCCUGUGCUCUGGCUUCCCUGGACC
00620385-		1091
99
ENSG000	1.286185086	SEQ	UUUCUUAGUUGGAAGUUGUGGUAGUUCUCCAGGCU
00205352-		ID	GGAGGACACACCUAAAC
ENST000		NO:
00549135-		1092
52
ENSG000	1.196031431	SEQ	AGACUGCGAAGGAGAACGCAGCAAGCCCAGGCGGC
00205352-		ID	GGUGGAAAGGCUGGAGGACACACCUAAAC
ENST000		NO:
00549581-		1093
64
ENSG000	1.234513358	SEQ	CGAACACCUCCAAC
00205403-		ID
ENST000		NO:
00512148-		1094
14
ENSG000	1.400709177	SEQ	AGUCCUGCUUCUCUUCCCUCUCUCCUCCAGCCUCUC
00205420-		ID	ACACUCUCCUCAGCUCUCUCAUCUCCUGGAACC
ENST000		NO:
00330722-		1095
69
ENSG000	1.511096092	SEQ	GAGAGACUACAACUCCCAGUAGUCACCGCG
00205456-		ID
ENST000		NO:
00569631-		1096
30
ENSG000	1.511096092	SEQ	GAGAGACUACAACUCCCAGUAGUCACCGCG
00205457-		ID
ENST000		NO:
00360260-		1097
30
ENSG000	1.110139908	SEQ	AGACACACACAGCCUCUCUGCCCACCUCUGCUUCCU
00206073-		ID	CUAGGAACACAGGAGUUCCAGAUCACAUCGAGUUC
ENST000		NO:	ACC
00341074-		1098
74
ENSG000	1.533402897	SEQ	AUUGAACUCCAUCUUCUGACACC
00206106-		ID
ENST000		NO:
00382830-		1099
23
ENSG000	1.094469431	SEQ	CUGGAAGGAAGCAGG
00206320-		ID
ENST000		NO:
00383279-		1100
15
ENSG000	1.185659153	SEQ	GGGGAACAUAGAGUGCUGAAGACAGAAUCUAGAGC
00206355-		ID	CUUCAAAUAAGUUGGAG
ENST000		NO:
00449364-		1101
52
ENSG000	1.209507245	SEQ	AAUCACUCCGGAGACUGAGCC
00206378-		ID
ENST000		NO:
00383379-		1102
21
ENSG000	1.133412347	SEQ	GCUGACGUGAAG
00206406-		ID
ENST000		NO:
00620798-		1103
12
ENSG000	1.499177611	SEQ	GGGGAACAUAGAGUGCUGGAGACAGAAUCUAGAGC
00206457-		ID	CUUCAAAUAAGUUGGAG
ENST000		NO:
00429943-		1104
52
ENSG000	1.38117268	SEQ	GCCGGAAGCGGAAAUAGCACCGGGCGCCGCCACAGU
00206490-		ID	AGCUGUAACUGCCACCGCG
ENST000		NO:
00424994-		1105
55
ENSG000	1.803398624	SEQ	AUAAACAAACAUUGAUUGCUUUCCUAUCUUACAUU
00206524-		ID	UUUUUAGGAGUGCGAAAUAAGUGAGUCAUC
ENST000		NO:
00383653-		1106
65
ENSG000	1.099729526	SEQ	UCAGCUCCCAGAGUGAUCCUGGACAGG
00206526-		ID
ENST000		NO:
00383656-		1107
27
ENSG000	1.168348872	SEQ	AUAAAAUCUGUGCUGUCAAACUGAUUAGGAACUGA
00211599-		ID	CUACCACCUGCAGGUCAGGGCCAAGGUU
ENST000		NO:
00390244-		1108
63
ENSG000	1.552173531	SEQ	AUCUUAAAAGAGGUUCUUUCUCUGGGAGUUGGCAG
00211611-		ID	UAGCAAAACUGACAAGUCAAGGCAGGAAG
ENST000		NO:
00390256-		1109
64
ENSG000	1.110137154	SEQ	CAAGUCACAGAUACAGAAGACCCCUCCGUCCUGGAG
00211724-		ID	CACCUGCC
ENST000		NO:
00390371-		1110
44
ENSG000	1.580879837	SEQ	AUUCUUUCUUCAAAGCAGCC
00211753-		ID
ENST000		NO:
00390400-		1111
20
ENSG000	1.263523387	SEQ	CACUGUGAUUUCUUCAGUUUAAGGAUCAAGACCAU
00211793-		ID	UAUUUGGGUAACACACUAAAG
ENST000		NO:
00390441-		1112
56
ENSG000	1.837518927	SEQ	AUUAUUUUUUUUUCGUGUUUAAGGUUUGAAUCCUC
00211794-		ID	AGUGAACCAGGGCAGAAAAGA
ENST000		NO:
00390442-		1113
56
ENSG000	1.140021391	SEQ	ACAGAAGUGGCGCCUCUGAGAAAAGAAGGUUGGAA
00211800-		ID	UUAUCGUAAUUUGUUUCUAGGCUGAGAUACCAGC
ENST000		NO:
00390448-		1114
69
ENSG000	1.800550963	SEQ	ACUAUUUCUAUUGAUCUGGAAGAAGCUUGUACCAG
00211806-		ID	GCAACCCAUUUAGGAGAAGUUGGAGUAAGAGGGAG
ENST000		NO:	AGGGAG
00390454-		1115
76
ENSG000	1.65030921	SEQ	AGCAUCAUCCAGAAACCACAUCCCUCCGCUAGAGAA
00211968-		ID	GCCCCUGACGGCACAGUUCCUCACU
ENST000		NO:
00390628-		1116
61
ENSG000	1.364868797	SEQ	UCACAACCAGUGAUAUUAGGCUUGCAUUUUCUUUC
00212126-		ID	UUUUUUUCUGCUCAGAU
ENST000		NO:
00506868-		1117
52
ENSG000	1.285281798	SEQ	AUUCACACCUCAGAAGCCUUAUCCUUCUUUUCAAUC
00212899-		ID	AAACCCAUAAAUACCACAGACUCUAAUAGCC
ENST000		NO:
00391586-		1118
67
ENSG000	1.553759704	SEQ	GUAGCCAUUCCUGAAUUUCUUUCAGCACUGGGAAA
00213139-		ID	ACCAGUCUAGUCACCAAAA
ENST000		NO:
00307944-		1119
54
ENSG000	1.099147505	SEQ	AUUUACUUCCUGCGGGUGCACAGGCUGUGGUCGUC
00213246-		ID	UAUCUCCCUGUUGUUCUUCCCAUCGGCGAAG
ENST000		NO:
00225504-		1120
66
ENSG000	1.236604787	SEQ	GUUGCUGGGAAG
00213380-		ID
ENST000		NO:
00306875-		1121
12
ENSG000	1.144582434	SEQ	UCCUAUCGAUAAGGUUCAGUUAGCCAAGGUGGAGG
00213424-		ID	AGUGGAAAAGA
ENST000		NO:
00581564-		1122
46
ENSG000	1.337584474	SEQ	CUAGUCUGCAUCUGAGUAAC
00213619-		ID
ENST000		NO:
00530295-		1123
20
ENSG000	1.117156616	SEQ	GUCUCUGGUUUCUGGCCCCUUGUCUGCAGAG
00213886-		ID
ENST000		NO:
00377050-		1124
31
ENSG000	1.13486989	SEQ	ACAUAUCUGCUUCCGACACAGCUGCAAUCACUAGCA
00213931-		ID	AGCUCUCAGGCCUGGCAUC
ENST000		NO:
00396895-		1125
55
ENSG000	1.856926054	SEQ	ACACUCGCUUCUGGAACGUCUGAGGUUAUCAAUAA
00213934-		ID	GCUCCUAGUCCAGACGCC
ENST000		NO:
00330597-		1126
53
ENSG000	1.426053561	SEQ	CAGCGCUUGAGGCUUGAAGAGGGAGACAAGCUAAA
00214050-		ID	AGAGGAUAUCCAGUUGUUUC
ENST000		NO:
00517673-		1127
55
ENSG000	1.281011584	SEQ	GUAAGUGUGAGAAAUUUGGCAAUAAAACCACCUAU
00214285-		ID	CUUUACAGAUUUUGGGAAGUCCAAA
ENST000		NO:
00398023-		1128
60
ENSG000	1.192857193	SEQ	GAGUGGAGAGGAAAAACAAAUUAUUUUUAAGUAUU
00214511-		ID	CACGGCAACCACAUUUAUAUCCUAUUGUUACUAGA
ENST000		NO:	GAAAAAA
00398455-		1129
77
ENSG000	1.100097911	SEQ	CAGUUGUACACC
00214782-		ID
ENST000		NO:
00529108-		1130
12
ENSG000	1.199888668	SEQ	UCAUUGCAGAGUCGAAAGCC
00214944-		ID
ENST000		NO:
00426542-		1131
20
ENSG000	1.101420533	SEQ	CAGCUCUCGGCUCUGCAGCGGAGCAUAGGCGACCAC
00215045-		ID	CACCGAAAGAGGCCACC
ENST000		NO:
00452113-		1132
53
ENSG000	1.173258273	SEQ	ACAGUGAACUCUGAUUCCUGGAAUUGUUACCAGGC
00215262-		ID	GACCACGGCGUCAUCAAAGUACCUGGCAAUUCCGUC
ENST000		NO:	UACUGAGUUCUCGAAC
00523973-		1133
87
ENSG000	1.094037583	SEQ	AUUUUCUCAAGCAAUUUUUAAAUUUCAUUCUUUUA
00215343-		ID	CCCUAUUGAGCUUUUCUUAGUGCCUAAAGUGUCUG
ENST000		NO:	CAAGUGGAAAUCCAGAGGAAGACAGAGAGAAACUG
00400085-		1134	AGUUCCUGACA
116
ENSG000	1.189210838	SEQ	ACAGGUUAGUAGUGCCAGUGAGCCGCCUUAGAUAG
00215421-		ID	AAGCAUCGUCAGCACUUUAUUA
ENST000		NO:
00309902-		1135
57
ENSG000	1.511500077	SEQ	UUUGUUGAGAGUGGAGUUGGAAAGUGUUAGCACUU
00215529-		ID	UGCCAGACUUUGCCAGCAAGAUUAACUGAGGAGAU
ENST000		NO:	CAAAUUGAGUCAGGGUCAAGGCUA
00400522-		1136
94
ENSG000	1.317594256	SEQ	AGGCCCUGUUUCCCUGAGCUCUCACCUCUGAUACAA
00221840-		ID	GCCUUAAAGAAGAGUAA
ENST000		NO:
00319760-		1137
53
ENSG000	1.346037672	SEQ	CCCAUUCUUGGCGCAGAAACCUGAAAGUCAGGAUC
00221937-		ID	AAAGAGA
ENST000		NO:
00408947-		1138
42
ENSG000	1.312935781	SEQ	CCUUCCUGGAGGUUUUAUCACCCACACUACAUAG
00221954-		ID
ENST000		NO:
00335238-		1139
34
ENSG000	1.185659153	SEQ	GGGGAACAUAGAGUGCUGAAGACAGAAUCUAGAGC
00223533-		ID	CUUCAAAUAAGUUGGAG
ENST000		NO:
00456365-		1140
52
ENSG000	1.185659153	SEQ	GGGGAACAUAGAGUGCUGAAGACAGAAUCUAGAGC
00224180-		ID	CUUCAAAUAAGUUGGAG
ENST000		NO:
00439536-		1141
52
ENSG000	1.133412347	SEQ	GCUGACGUGAAG
00224398-		ID
ENST000		NO:
00621203-		1142
12
ENSG000	1.133412347	SEQ	GCUGACGUGAAG
00224774-		ID
ENST000		NO:
00622139-		1143
12
ENSG000	1.384930042	SEQ	GGUAUCUUAAAAGAGGUUCUUUCUCUGGGAGUUGG
00225523-		ID	CAGUAGCAAAACUGACAAGUCAAGGCAGGAAG
ENST000		NO:
00436451-		1144
67
ENSG000	1.803398624	SEQ	AUAAACAAACAUUGAUUGCUUUCCUAUCUUACAUU
00225736-		ID	UUUUUAGGAGUGCGAAAUAAGUGAGUCAUC
ENST000		NO:
00456140-		1145
65
ENSG000	1.141243899	SEQ	UCCUCACAAUUACUCUACAGCUCAGAACAGCAACUG
00225890-		ID	CUGAGGCUGCCUUGGGAAGAAG
ENST000		NO:
00416403-		1146
58
ENSG000	2.012761787	SEQ	CACACUCUGCCUUUGGACGUGAGAGAGAGCGCACCU
00225899-		ID	UUCACUUGAGCUUCAAC
ENST000		NO:
00425520-		1147
53
ENSG000	1.38117268	SEQ	GCCGGAAGCGGAAAUAGCACCGGGCGCCGCCACAGU
00225989-		ID	AGCUGUAACUGCCACCGCG
ENST000		NO:
00441688-		1148
55
ENSG000	1.803398624	SEQ	AUAAACAAACAUUGAUUGCUUUCCUAUCUUACAUU
00226832-		ID	UUUUUAGGAGUGCGAAAUAAGUGAGUCAUC
ENST000		NO:
00415976-		1149
65
ENSG000	1.613901653	SEQ	ACCUUCGCCCUAAGUCCUUUACCAAUAGUGCGGCAC
00227322-		ID	UCCGGUAGCGACGAAUCCAUCCUGCACUGACACGC
ENST000		NO:
00531100-		1150
71
ENSG000	1.12821117	SEQ	UUCAGUCUCA
00227507-		ID
ENST000		NO:
00446745-		1151
10
ENSG000	1.302467484	SEQ	AGAAAACCUACAACCCAAGGUUCAGUGUUACCCCUC
00228083-		ID	AUCAACCAGCCCAGCAGCAUCUUCGGGAUUCCCA
ENST000		NO:
00380222-		1152
70
ENSG000	1.209507245	SEQ	AAUCACUCCGGAGACUGAGCC
00228263-		ID
ENST000		NO:
00425238-		1153
21
ENSG000	1.233260608	SEQ	CUCUGACUUCGGGCUUGUUCGCUGGUGGCGUCGGA
00228474-		ID	GCCGAGCCGGACUGGUCAGG
ENST000		NO:
00456793-		1154
55
ENSG000	1.133412347	SEQ	GCUGACGUGAAG
00228875-		ID
ENST000		NO:
00614974-		1155
12
ENSG000	1.094469431	SEQ	CUGGAAGGAAGCAGG
00229058-		ID
ENST000		NO:
00412470-		1156
15
ENSG000	1.209507245	SEQ	AAUCACUCCGGAGACUGAGCC
00229077-		ID
ENST000		NO:
00415517-		1157
21
ENSG000	1.094469431	SEQ	CUGGAAGGAAGCAGG
00230514-		ID
ENST000		NO:
00412794-		1158
15
ENSG000	1.099729526	SEQ	UCAGCUCCCAGAGUGAUCCUGGACAGG
00231041-		ID
ENST000		NO:
00421470-		1159
27
ENSG000	1.38117268	SEQ	GCCGGAAGCGGAAAUAGCACCGGGCGCCGCCACAGU
00231129-		ID	AGCUGUAACUGCCACCGCG
ENST000		NO:
00426591-		1160
55
ENSG000	1.094469431	SEQ	CUGGAAGGAAGCAGG
00231268-		ID
ENST000		NO:
00418313-		1161
15
ENSG000	1.803398624	SEQ	AUAAACAAACAUUGAUUGCUUUCCUAUCUUACAUU
00231319-		ID	UUUUUAGGAGUGCGAAAUAAGUGAGUCAUC
ENST000		NO:
00419873-		1162
65
ENSG000	1.209507245	SEQ	AAUCACUCCGGAGACUGAGCC
00231479-		ID
ENST000		NO:
00453831-		1163
21
ENSG000	1.141489866	SEQ	AAAGUUUAUUCAGCUUUUCGAUCCGCCAUCUGCAG
00231767-		ID	UGGAGCCGCCACCAAA
ENST000		NO:
00647225-		1164
51
ENSG000	1.38117268	SEQ	GCCGGAAGCGGAAAUAGCACCGGGCGCCGCCACAGU
00232169-		ID	AGCUGUAACUGCCACCGCG
ENST000		NO:
00429395-		1165
55
ENSG000	1.209507245	SEQ	AAUCACUCCGGAGACUGAGCC
00232180-		ID
ENST000		NO:
00442152-		1166
21
ENSG000	1.740603439	SEQ	GAAGGAAAGAGUAACUUGAGUUUCACUUCUUAGUG
00232869-		ID	CCUUUUCUCAGGGGAGAGGCCAUCACUUGAAG
ENST000		NO:
00422143-		1167
67
ENSG000	1.803398624	SEQ	AUAAACAAACAUUGAUUGCUUUCCUAUCUUACAUU
00233054-		ID	UUUUUAGGAGUGCGAAAUAAGUGAGUCAUC
ENST000		NO:
00420178-		1168
65
ENSG000	1.803398624	SEQ	AUAAACAAACAUUGAUUGCUUUCCUAUCUUACAUU
00233180-		ID	UUUUUAGGAGUGCGAAAUAAGUGAGUCAUC
ENST000		NO:
00444830-		1169
65
ENSG000	1.099729526	SEQ	UCAGCUCCCAGAGUGAUCCUGGACAGG
00233566-		ID
ENST000		NO:
00438403-		1170
27
ENSG000	1.803398624	SEQ	AUAAACAAACAUUGAUUGCUUUCCUAUCUUACAUU
00233687-		ID	UUUUUAGGAGUGCGAAAUAAGUGAGUCAUC
ENST000		NO:
00450817-		1171
65
ENSG000	1.17875259	SEQ	GUUGACAGAGCUACCGUCUUCCUGUUUUUUUCCUCC
00233822-		ID	AAUUUUCCGGCAGUUACUCCCAGUC
ENST000		NO:
00606613-		1172
61
ENSG000	1.185659153	SEQ	GGGGAACAUAGAGUGCUGAAGACAGAAUCUAGAGC
00234114-		ID	CUUCAAAUAAGUUGGAG
ENST000		NO:
00444737-		1173
52
ENSG000	1.094469431	SEQ	CUGGAAGGAAGCAGG
00234729-		ID
ENST000		NO:
00434502-		1174
15
ENSG000	1.209507245	SEQ	AAUCACUCCGGAGACUGAGCC
00235336-		ID
ENST000		NO:
00417894-		1175
21
ENSG000	1.38117268	SEQ	GCCGGAAGCGGAAAUAGCACCGGGCGCCGCCACAGU
00236149-		ID	AGCUGUAACUGCCACCGCG
ENST000		NO:
00423030-		1176
55
ENSG000	1.38117268	SEQ	GCCGGAAGCGGAAAUAGCACCGGGCGCCGCCACAGU
00236342-		ID	AGCUGUAACUGCCACCGCG
ENST000		NO:
00418552-		1177
55
ENSG000	1.141243899	SEQ	UCCUCACAAUUACUCUACAGCUCAGAACAGCAACUG
00236418-		ID	CUGAGGCUGCCUUGGGAAGAAG
ENST000		NO:
00442315-		1178
58
ENSG000	1.099729526	SEQ	UCAGCUCCCAGAGUGAUCCUGGACAGG
00237313-		ID
ENST000		NO:
00434916-		1179
27
ENSG000	1.094469431	SEQ	CUGGAAGGAAGCAGG
00237405-		ID
ENST000		NO:
00441753-		1180
15
ENSG000	1.733843671	SEQ	ACAAUUGCUCUACAGCUCAGAGCAGCAACUGCUGA
00237541-		ID	GGCUGCCUUGGGAAGAAG
ENST000		NO:
00374940-		1181
53
ENSG000	1.099729526	SEQ	UCAGCUCCCAGAGUGAUCCUGGACAGG
00237634-		ID
ENST000		NO:
00438996-		1182
27
ENSG000	1.150959433	SEQ	UUAGUUCUUCCUGAGGUCUGAGCACCCUCCAAACUG
00237700-		ID	AGUCCAGAUCUGAGUUUUUCCUCGGAGAUUUGUCA
ENST000		NO:	GA
00437300-		1183
73
ENSG000	1.35564606	SEQ	UCUUCAUUCUUUCCGCCAUCUUGAUUCUUUGUCACU
00238269-		ID	GACCGAGACUCAGCCGUGGGAAAU
ENST000		NO:
00374974-		1184
60
ENSG000	1.429580126	SEQ	GACAGUUUGAGGUAAGGCGUUGUAUAUAUUGCAGA
00239389-		ID	UAGCUCUGAGGUUUUUGGAGUGUACC
ENST000		NO:
00409494-		1185
61
ENSG000	1.270018906	SEQ	AGGCUGGACACACUUCAGUCAGGAGUCAGACCCUG
00240671-		ID	UCAGGACACAGCAUAGAC
ENST000		NO:
00495489-		1186
53
ENSG000	1.29421234	SEQ	UCUCUCUUAUCUUCUGGCCUGCCUGGAGUUUCAAG
00241186-		ID	GGAACAAGUACAGAGUGUGAUUUGGAUC
ENST000		NO:
00542931-		1187
63
ENSG000	1.365944978	SEQ	UGGAAAAUCCCU
00241322-		ID
ENST000		NO:
00630868-		1188
12
ENSG000	1.123661671	SEQ	ACAUUUCAGGGACACC
00241644-		ID
ENST000		NO:
00013222-		1189
16
ENSG000	1.498382268	SEQ	CUGGGAAGCGCC
00242110-		ID
ENST000		NO:
00382072-		1190
12
ENSG000	1.221715055	SEQ	UUUUCGUCGACUCUUACCGGUUGGCUGGGCCAGCU
00242247-		ID	GCGCCGCGGCUCACAGCUGACG
ENST000		NO:
00437119-		1191
57
ENSG000	1.223653081	SEQ	AAACCUUUUUAGGGAGUCCAAGGUACAGUCGCCGC
00242372-		ID	GUGCGGAGCUUGUUACUGGUUACUUGGCCUC
ENST000		NO:
00415116-		1192
66
ENSG000	1.705298272	SEQ	AUAGGUUGGCACUCAUCAGUAGCCCCUGUUCUCAU
00243716-		ID	UCUGCAA
ENST000		NO:
00517347-		1193
42
ENSG000	1.321173039	SEQ	UAAACUCCUGGUACCUAAGCACCGAUCUGCCUUGGA
00244094-		ID	GAACCUGAUUCUGAGACUCCAGCAGG
ENST000		NO:
00468739-		1194
62
ENSG000	1.749866577	SEQ	AAACCUUCCAAACCCACCUUCCUGGAAAUCCACCCA
00244537-		ID	GAACCUCCACCCUCUGACACC
ENST000		NO:
00377726-		1195
57
ENSG000	1.391560559	SEQ	UGAAGACAGCCACACAGAUAUUGCACAGACUAUUU
00248329-		ID	ACAGAUCGUUUGGUUUACAUUGAGAGUCAUUGCUC
ENST000		NO:	UACUUUUGUGCGGUAGGAAA
00510062-		1196
90
ENSG000	2.044843971	SEQ	UCCACUGGCCAGCAUUCUCCUCUAUUAGACUAGAAC
00249437-		ID	UGUGGAUAAACCUCAGAAA
ENST000		NO:
00508426-		1197
55
ENSG000	1.206064157	SEQ	ACUCAGAAGACUGGACACAAUUCCGAAGGUCGCCCA
00249861-		ID	GAAGGAGAGGACA
ENST000		NO:
00392051-		1198
49
ENSG000	1.367711867	SEQ	AAGACUGGACACAAUUCCGAAGGUCGCCCAGAAGG
00249861-		ID	AGAGGACA
ENST000		NO:
00594480-		1199
43
ENSG000	1.269420374	SEQ	GUCUUUGGUAGUUUUUUUGCACUAACUUCAGGAAC
00250361-		ID	CAGCUCAGUAUCUCAGG
ENST000		NO:
00506679-		1200
52
ENSG000	1.399051287	SEQ	ACAAGAGCAAGCAGAACCUCUCUGACCGCUCGCGCC
00251184-		ID	AGGCCUACACUUUCCACCUC
ENST000		NO:
00482796-		1201
56
ENSG000	1.570950729	SEQ	CUGGCCAGAUCUCUCUACACAGGUAAAAGAGUAAG
00254658-		ID	CCAACAAUACAA
ENST000		NO:
00641465-		1202
47
ENSG000	1.094703228	SEQ	AUUGCAAGUGUAACACACAUUGCAAGUGCCAACGU
00255501-		ID	GAGGAGCC
ENST000		NO:
00530950-		1203
43
ENSG000	1.13946171	SEQ	GUGGUGGCAGAGGUGCUUGUGUUUUUGUCGGUACA
00255508-		ID	GGAGAGUCGCU
ENST000		NO:
00496634-		1204
46
ENSG000	1.240199969	SEQ	GUUGCUACCGGA
00256061-		ID
ENST000		NO:
00524160-		1205
12
ENSG000	1.283101369	SEQ	AUUGAGUAAAAUUGGGUUACCCUGAGGACUCUUGC
00256394-		ID	UUAACUGAAAUCACAA
ENST000		NO:
00537611-		1206
51
ENSG000	1.316464457	SEQ	UUUCCGGUGCAGGUGGGGAAA
00256591-		ID
ENST000		NO:
00544801-		1207
21
ENSG000	1.781446799	SEQ	ACAGUGCGCAGUUGUGCGGCUGUGCUUUGGCUCUU
00256646-		ID	CGGGUAAAG
ENST000		NO:
00676779-		1208
44
ENSG000	1.146990359	SEQ	CAUCUCCAGGCUCCAUCUCUUGAACCAGUGAUCCCA
00257008-		ID	GCGUUGUUAGCA
ENST000		NO:
00335666-		1209
48
ENSG000	1.218398343	SEQ	AUUGCUAAGCCAUCCUUCAGACAGAGAGGGAGCGG
00257335-		ID	CUGCAAGAGGUAAGUAGAG
ENST000		NO:
00475668-		1210
54
ENSG000	1.09796851	SEQ	CUCACUCCGUCUCAAUAGUUCUCAAG
00257923-		ID
ENST000		NO:
00292538-		1211
26
ENSG000	1.14068138	SEQ	CACUCCGUCUCAAUAGUUCUCAAG
00257923-		ID
ENST000		NO:
00622516-		1212
24
ENSG000	1.295409723	SEQ	ACAGCGGUCACGUGAC
00258311-		ID
ENST000		NO:
00550412-		1213
16
ENSG000	1.383552553	SEQ	CGUAUCGCUUGGAGUGAAGGUCCUACCGCGGCAGU
00258405-		ID	AUUGAUUUCUAAAGACUC
ENST000		NO:
00601120-		1214
53
ENSG000	1.133412347	SEQ	GCUGACGUGAAG
00258543-		ID
ENST000		NO:
00620322-		1215
12
ENSG000	1.133412347	SEQ	GCUGACGUGAAG
00258589-		ID
ENST000		NO:
00614071-		1216
12
ENSG000	1.31134311	SEQ	GUCUCCCAGACAGUGGCUCAGCCUUCAGGACUCUCU
00258873-		ID	UCCAGC
ENST000		NO:
00554048-		1217
42
ENSG000	1.229055946	SEQ	GAGAACGAAAG
00259494-		ID
ENST000		NO:
00312475-		1218
11
ENSG000	1.179253942	SEQ	CCGGGCCAGUUAGAUUUGGAGGUUCAACUUCAAC
00260238-		ID
ENST000		NO:
00490491-		1219
34
ENSG000	1.511096092	SEQ	GAGAGACUACAACUCCCAGUAGUCACCGCG
00261509-		ID
ENST000		NO:
00569741-		1220
30
ENSG000	1.340249819	SEQ	ACUCUCUUGCUCACAGUCCACG
00261857-		ID
ENST000		NO:
00263369-		1221
22
ENSG000	1.321392507	SEQ	CUAGGCCUCUGUGAUUGUUGAGGAGGGGGCUGUCA
00261857-		ID	CUGGGAAAGUUUCCACG
ENST000		NO:
00597784-		1222
52
ENSG000	1.13138728	SEQ	CCUCCCACUCUGCCUAGAGUC
00262152-		ID
ENST000		NO:
00573315-		1223
21
ENSG000	1.35823703	SEQ	ACAGUCCCUCUGAGCUGCACGGAGACCUCGCAGGCC
00262243-		ID	CCCGGAACUGUCGCCCUUCCAGG
ENST000		NO:
00571922-		1224
59
ENSG000	1.378656618	SEQ	AGAAAGGAACACAGUAAACUGAAUUGAUCCGUUUA
00262406-		ID	GAAGUUUACA
ENST000		NO:
00571244-		1225
45
ENSG000	1.185966521	SEQ	AGAGGAGGAAAUUGUUCCUCGUCUGAUAAGACAAC
00262418-		ID	AGUGGAGAAAGGACGCAGUCUGUUUCUUAGGGACA
ENST000		NO:	CGGCUGACUUCCAGAUAGUACC
00573477-		1226
92
ENSG000	1.13357079	SEQ	GCUGUGAGGACGUGUUCCGAGGAAGCCAGAGCCGG
00262633-		ID	AGCCGUGGCCUGCGGGGCCGGCGAC
ENST000		NO:
00571841-		1227
60
ENSG000	1.116135805	SEQ	AAGGUCAAGUAUAGCAUCUGCCUAGAGUCAAACCU
00262635-		ID	CCGUGCUUCUCAGACAGUGCCUUUUCACC
ENST000		NO:
00573403-		1228
64
ENSG000	1.71541121	SEQ	UAGAUCGUCAGGAAAAGCCUAAAGAUUAGACUGUA
00262771-		ID	AGAAAAGAAAAUAGAAGCC
ENST000		NO:
00575059-		1229
54
ENSG000	1.133412347	SEQ	GCUGACGUGAAG
00263020-		ID
ENST000		NO:
00617558-		1230
12
ENSG000	1.281767423	SEQ	CAACCAUCCUGAAGCUACAGGUGCUCCCUCCUGGAA
00263057-		ID	UCUCCA
ENST000		NO:
00576098-		1231
42
ENSG000	1.124660387	SEQ	ACUAUAAAGACAGUAAAAAGAUCAGUGGUUAUCUU
00263353-		ID	UGCAGACGCCACCAUCACUGUGAGCCCUGUACUAUC
ENST000		NO:	AGCC
00577856-		1232
75
ENSG000	1.146281715	SEQ	CCUUUUGCGGCCAUCACCGAAGCGGGAGCGGGUAA
00263809-		ID	GGAUUCGGCGGCCAAA
ENST000		NO:
00582471-		1233
51
ENSG000	1.452842383	SEQ	AUCGAUAAGGUUCAGUUAGCCAAGGUGGAGGAGUG
00264058-		ID	GAAAAGA
ENST000		NO:
00476049-		1234
42
ENSG000	1.160205569	SEQ	GAGAUCUCGAUCGAAGGCGAG
00265241-		ID
ENST000		NO:
00632555-		1235
21
ENSG000	1.196291602	SEQ	GUGAGUGGAAGCUCUGGUGCAGCAGU
00266200-		ID
ENST000		NO:
00579578-		1236
26
ENSG000	1.168317499	SEQ	GAGAACCCUUCCGGUGGGCUAGGUACUGAGCGCGC
00266472-		ID	GAGGCUCUACAGAGUGAAGGUUUAAAUCCAAGGUC
ENST000		NO:
00614145-		1237
70
ENSG000	1.400626424	SEQ	ACGCUGGGUUCUGCUUUUCCAGAAUCCUGCCCUUUC
00267508-		ID	CAAAAGGAAGACGGU
ENST000		NO:
00591679-		1238
51
ENSG000	1.231330075	SEQ	UGUGGGGAGGGUACCUCUCACAGAAGAGUCUUAGU
00267561-		ID	ACUGGCAUCAGGGGAAGGUCACCAAGUCUUUCCUG
ENST000		NO:	UAC
00370548-		1239
73
ENSG000	1.193216716	SEQ	ACUAUAAAGACAGUAAAAAGAUCAGUGGUUAUCUU
00270339-		ID	UGCAGACGCCACCAUCGCUGUGAGCCCUGUACUAUC
ENST000		NO:	AGCC
00584068-		1240
75
ENSG000	1.452536745	SEQ	ACCCUCUCACAUCCCAGUCUCUGAUCAGGGAAAGCA
00270806-		ID	GGGCACAGCCUUGGGAAGA
ENST000		NO:
00605587-		1241
55
ENSG000	1.199203721	SEQ	AAAGUGCUGUGGGGAGUGAUCACAUUUUUCACAAC
00271254-		ID	AUCCCUGGCUCCACCUCUUCUGCCACAAACGUCAGC
ENST000		NO:
00612640-		1242
71
ENSG000	1.265660288	SEQ	CGACUUUCCCGAUCGCCAGGCAGGAGUUUCUCUCGG
00272196-		ID	UGACUACUAUCGCUGUC
ENST000		NO:
00607355-		1243
53
ENSG000	1.995713916	SEQ	AAGCUAGGGCCACC
00272414-		ID
ENST000		NO:
00509377-		1244
14
ENSG000	2.074341985	SEQ	CCGCCUGUCUGCACCGGCAGCACC
00273518-		ID
ENST000		NO:
00619271-		1245
24
ENSG000	1.173655751	SEQ	ACAAAGCGUUGGGUGAGACUCCUCUUGCUCGUC
00273542-		ID
ENST000		NO:
00611927-		1246
33
ENSG000	2.074341985	SEQ	CCGCCUGUCUGCACCGGCAGCACC
00273775-		ID
ENST000		NO:
00615036-		1247
24
ENSG000	1.112044721	SEQ	CUCUUUCUCAGUGACCGGGUGGUUUGCUUAGGCGC
00274005-		ID	AGACGGGGAAGCGGAGCCAAC
ENST000		NO:
00617291-		1248
56
ENSG000	1.535124669	SEQ	CCUGUCUGCACAGACAGCACC
00274108-		ID
ENST000		NO:
00617593-		1249
21
ENSG000	2.074341985	SEQ	CCGCCUGUCUGCACCGGCAGCACC
00274146-		ID
ENST000		NO:
00614221-		1250
24
ENSG000	1.511096092	SEQ	GAGAGACUACAACUCCCAGUAGUCACCGCG
00274175-		ID
ENST000		NO:
00616638-		1251
30
ENSG000	2.039968479	SEQ	AGCUGGGGCGCAGCCGCCUGUCUGCACCGGCAGCAC
00274283-		ID	C
ENST000		NO:
00610591-		1252
37
ENSG000	2.039968479	SEQ	AGCUGGGGCGCAGCCGCCUGUCUGCACCGGCAGCAC
00274465-		ID	C
ENST000		NO:
00620498-		1253
37
ENSG000	1.107255084	SEQ	UUCUUCAGCCUUAACCUAAGGUCUCAUACUCGGAGC
00274571-		ID	ACU
ENST000		NO:
00610853-		1254
39
ENSG000	1.283579852	SEQ	GGGUCUUCUCAAGGAAAUCCCAAUCUCUAUUCCGA
00274729-		ID	AGAGUCUUCCCUAAAAG
ENST000		NO:
00611610-		1255
52
ENSG000	1.238040775	SEQ	AUUAACACUUGGGUAACUUACCCUUCACAAUCCAUC
00274749-		ID	UAAAUCCUUCUCAAUUGCUGCCACC
ENST000		NO:
00621162-		1256
61
ENSG000	1.174777913	SEQ	AUUUACUUUGCAGAGUAACU
00274750-		ID
ENST000		NO:
00614911-		1257
20
ENSG000	2.074341985	SEQ	CCGCCUGUCUGCACCGGCAGCACC
00274920-		ID
ENST000		NO:
00621759-		1258
24
ENSG000	2.012761787	SEQ	CACACUCUGCCUUUGGACGUGAGAGAGAGCGCACCU
00274972-		ID	UUCACUUGAGCUUCAAC
ENST000		NO:
00611713-		1259
53
ENSG000	1.511096092	SEQ	GAGAGACUACAACUCCCAGUAGUCACCGCG
00275034-		ID
ENST000		NO:
00611321-		1260
30
ENSG000	2.039968479	SEQ	AGCUGGGGCGCAGCCGCCUGUCUGCACCGGCAGCAC
00275037-		ID	C
ENST000		NO:
00615875-		1261
37
ENSG000	1.185393876	SEQ	CUGCUCAGCACUAGGCCGGCAGAAUCUGAGCG
00275156-		ID
ENST000		NO:
00611318-		1262
32
ENSG000	1.585246933	SEQ	AAAAGAAUUAUCACAUUGCACAAGG
00275190-		ID
ENST000		NO:
00627047-		1263
25
ENSG000	1.185393876	SEQ	CUGCUCAGCACUAGGCCGGCAGAAUCUGAGCG
0027552-		ID
ENST000		NO:
00614280-		1264
32
ENSG000	1.296134122	SEQ	AGCUCGGUCGCGGCUGCCUGUCUGCUCCGGCAGCAC
00275522-		ID	C
ENST000		NO:
00613465-		1265
37
ENSG000	2.074341985	SEQ	CCGCCUGUCUGCACCGGCAGCACC
00275545-		ID
ENST000		NO:
00622691-		1266
24
ENSG000	1.120167319	SEQ	ACCGGCAGCACC
00275566-		ID
ENST000		NO:
00613612-		1267
12
ENSG000	1.294164141	SEQ	ACGUAGACCGUCUGCUGGGGGCGCCGGCACCAUUUG
00275600-		ID	GAGUACGUGAGGAAGAAAA
ENST000		NO:
00616581-		1268
55
ENSG000	2.039968479	SEQ	AGCUGGGGCGCAGCCGCCUGUCUGCACCGGCAGCAC
00275608-		ID	C
ENST000		NO:
00622416-		1269
37
ENSG000	1.185296402	SEQ	GCAGCAGUUUUCUACGUCUGAAAUUUUUUAGUUCU
00275618-		ID	CUGGAACCCAGAAUUUGCUAAGAG
ENST000		NO:
00631651-		1270
59
ENSG000	1.185393876	SEQ	CUGCUCAGCACUAGGCCGGCAGAAUCUGAGCG
00275637-		ID
ENST000		NO:
00616589-		1271
32
ENSG000	2.074341985	SEQ	CCGCCUGUCUGCACCGGCAGCACC
00275717-		ID
ENST000		NO:
00619277-		1272
24
ENSG000	1.106047389	SEQ	UUAGCUGAACUGAGCUGAAAUCCUAAAGGCCGCGG
00275748-		ID	AGUCGGCGGUGUUGUAGGUAGCGGUACCUUGAGUG
ENST000		NO:	GCAACAGAAUUCGAUUAAAUUACA
00626328-		1273
94
ENSG000	2.074341985	SEQ	CCGCCUGUCUGCACCGGCAGCACC
00275786-		ID
ENST000		NO:
00619931-		1274
24
ENSG000	1.184025816	SEQ	AGUAGAUCCUGGCCUGGACCUGAA
00275791-		ID
ENST000		NO:
00611462-		1275
24
ENSG000	1.351209686	SEQ	GAAGGCUAGACCCGGUUUACUGGAAUUGCUCUGGC
00275903-		ID	GAUCGAGGGAUCCUAGUACACCGCAAUC
ENST000		NO:
00631787-		1276
63
ENSG000	1.525878034	SEQ	ACCCGGUUUACUGGAAUUGCUCUGGCGAUCGAGGG
00275903-		ID	AUCCUAGUACACCGCAAUC
ENST000		NO:
00631987-		1277
54
ENSG000	2.044843971	SEQ	UCCACUGGCCAGCAUUCUCCUCUAUUAGACUAGAAC
00276068-		ID	UGUGGAUAAACCUCAGAAA
ENST000		NO:
00615009-		1278
55
ENSG000	1.105796845	SEQ	AGAAGGACGCAGGCAGCAAAGAGUAGUCAGUCCCU
00276085-		ID	UCUUGGCUCUGCUGACACUCGAGCCCACAUUCCAUC
ENST000		NO:	ACCUGCUCCCAAUC
00619989-		1279
85
ENSG000	1.364868797	SEQ	UCACAACCAGUGAUAUUAGGCUUGCAUUUUCUUUC
00276167-		ID	UUUUUUUCUGCUCAGAU
ENST000		NO:
00613831-		1280
52
ENSG000	1.460575417	SEQ	AGAAAGUUUAAAGUGCUGAGUGAUUUGCACUAGCU
00276262-		ID	GUAUAGAUCUUUGGUGGAGGAGGAAAGUGGAAAAU
ENST000		NO:	UAUUAAUUUCAGAGC
00632852-		1281
85
ENSG000	1.296134122	SEQ	AGCUCGGUCGCGGCUGCCUGUCUGCUCCGGCAGCAC
00276310-		ID	C
ENST000		NO:
00610627-		1282
37
ENSG000	2.039968479	SEQ	AGCUGGGGCGCAGCCGCCUGUCUGCACCGGCAGCAC
00276498-		ID	C
ENST000		NO:
00621225-		1283
37
ENSG000	2.039968479	SEQ	AGCUGGGGCGCAGCCGCCUGUCUGCACCGGCAGCAC
00276534-		ID	C
ENST000		NO:
00618890-		1284
37
ENSG000	1.157998465	SEQ	UUCUUUUUUGAGGUUUUGAGGUUUUGCUGAAGAUA
00276559-		ID	UUCCUGAAGAAUCAUCCCAGGUGCCACACUAAAAA
ENST000		NO:	A
00621712-		1285
71
ENSG000	2.319422253	SEQ	GUGAAUUAUAGUUUAAGUUACUGCAAGUCCUAAAC
00276618-		ID	UACGGAGUGGAACUAUUACAGUUUAUA
ENST000		NO:
00621806-		1286
62
ENSG000	1.422729345	SEQ	AGCGCAGCGGCGUCCGAGGCAACAAG
00276657-		ID
ENST000		NO:
00632107-		1287
26
ENSG000	1.440297711	SEQ	AAAUUCAGGGUCCAGCUCACAGUGGAAAUACUUUC
00276775-		ID	UGAGAGUCAGUGACCUCCUGCACAAGAAC
ENST000		NO:
00455737-		1288
64
ENSG000	1.474102416	SEQ	AUUAAUAUUAAGAUUGGAAGUUUGUGUCUUUUGCU
00276776-		ID	GGAUAUUGGAAAUUGAAGUUA
ENST000		NO:
00610758-		1289
56
ENSG000	1.19630846	SEQ	UUUGCUCAGUUUCACAGAGGGCCUGGUCUGGAAUA
00276953-		ID	UUCCACAUCUGCUCUCACUCUGCC
ENST000		NO:
00617347-		1290
59
ENSG000	2.359433846	SEQ	AGUCUUCAUUUAGGUCCGAAUUCCCGGCAUAUAAG
00276966-		ID	AAUACUACCGUCGCUUGUUUUUCAGAUUUUUGCGG
ENST000		NO:	CUAUUUUCGUUGGUGUGUUGGUC
00615164-		1291
93
ENSG000	1.186722356	SEQ	GGUGGAAGAAGUAAAGAAAAGAAAGAGUAAAGGAG
00277140-		ID	UUUGAAUCACUUUGCAGUGCUGU
ENST000		NO:
00631398-		1292
58
ENSG000	1.294164141	SEQ	ACGUAGACCGUCUGCUGGGGGCGCCGGCACCAUUUG
00277161-		ID	GAGUACGUGAGGAAGAAAA
ENST000		NO:
00620233-		1293
55
ENSG000	2.074341985	SEQ	CCGCCUGUCUGCACCGGCAGCACC
00277175-		ID
ENST000		NO:
00616424-		1294
24
ENSG000	1.198507693	SEQ	GCAUUUCUCUUUAGGUUGUGGACGAAGUGUUUAUU
00277224-		ID	UAUC
ENST000		NO:
00356530-		1295
39
ENSG000	1.185393876	SEQ	CUGCUCAGCACUAGGCCGGCAGAAUCUGAGCG
00277334-		ID
ENST000		NO:
00616389-		1296
32
ENSG000	1.105796845	SEQ	AGAAGGACGCAGGCAGCAAAGAGUAGUCAGUCCCU
00277336-		ID	UCUUGGCUCUGCUGACACUCGAGCCCACAUUCCAUC
ENST000		NO:	ACCUGCUCCCAAUC
00621940-		1297
85
ENSG000	1.185393876	SEQ	CUGCUCAGCACUAGGCCGGCAGAAUCUGAGCG
00277442-		ID
ENST000		NO:
00616747-		1298
32
ENSG000	1.103341541	SEQ	UCAGGGCAGUAGAACAUAUUUUAAUCAAGUCCCCU
00277530-		ID	UGAUAAAAGAGCUUGAUUCCAGCUACUGCACUUCC
ENST000		NO:	UUCAUCAGCUCUCCACUG
00615431-		1299
88
ENSG000	1.296134122	SEQ	AGCUCGGUCGCGGCUGCCUGUCUGCUCCGGCAGCAC
00277616-		ID	C
ENST000		NO:
00612069-		1300
37
ENSG000	1.105796845	SEQ	AGAAGGACGCAGGCAGCAAAGAGUAGUCAGUCCCU
00277768-		ID	UCUUGGCUCUGCUGACACUCGAGCCCACAUUCCAUC
ENST000		NO:	ACCUGCUCCCAAUC
00615140-		1301
85
ENSG000	1.351209686	SEQ	GAAGGCUAGACCCGGUUUACUGGAAUUGCUCUGGC
00277791-		ID	GAUCGAGGGAUCCUAGUACACCGCAAUC
ENST000		NO:
00613870-		1302
63
ENSG000	1.525878034	SEQ	ACCCGGUUUACUGGAAUUGCUCUGGCGAUCGAGGG
00277791-		ID	AUCCUAGUACACCGCAAUC
ENST000		NO:
00620309-		1303
54
ENSG000	1.105796845	SEQ	AGAAGGACGCAGGCAGCAAAGAGUAGUCAGUCCCU
00277796-		ID	UCUUGGCUCUGCUGACACUCGAGCCCACAUUCCAUC
ENST000		NO:	ACCUGCUCCCAAUC
00612067-		1304
85
ENSG000	1.185393876	SEQ	CUGCUCAGCACUAGGCCGGCAGAAUCUGAGCG
00278025-		ID
ENST000		NO:
00619741-		1305
32
ENSG000	1.460575417	SEQ	AGAAAGUUUAAAGUGCUGAGUGAUUUGCACUAGCU
00278174-		ID	GUAUAGAUCUUUGGUGGAGGAGGAAAGUGGAAAAU
ENST000		NO:	UAUUAAUUUCAGAGC
00626883-		1306
85
ENSG000	2.074341985	SEQ	CCGCCUGUCUGCACCGGCAGCACC
00278368-		ID
ENST000		NO:
00614464-		1307
24
ENSG000	1.284513079	SEQ	UCGACAGUCCACAAAGGCACAGUAUAAAAACGGUG
00278373-		ID	GGAAUCAGAGCACUUCAGCUCCAAUUGCUCUAGUU
ENST000		NO:	UUAGAAUUGCCUCUUUUUCAAG
00622133-		1308
92
ENSG000	1.242970876	SEQ	GUAGUUUCAUUACAUUUUCUUGUGGCGAUUUUCCC
00278463-		ID	UUAUCAGAAGUAGUU
ENST000		NO:
00615868-		1309
50
ENSG000	1.611121882	SEQ	ACAGAAAGUAGCUCAUUCCUCCUAACUGGGUAAUA
00278494-		ID	GACAGUGGUGGGGCCUGGAAAAGAUUUCAAAU
ENST000		NO:
00632541-		1310
67
ENSG000	1.296134122	SEQ	AGCUCGGUCGCGGCUGCCUGUCUGCUCCGGCAGCAC
00278503-		ID	C
ENST000		NO:
00618507-		1311
37
ENSG000	2.044843971	SEQ	UCCACUGGCCAGCAUUCUCCUCUAUUAGACUAGAAC
00278613-		ID	UGUGGAUAAACCUCAGAAA
ENST000		NO:
00610590-		1312
55
ENSG000	1.331947963	SEQ	CCACCACCAGCAAACAAGGGGCAGCGUGGAGGAGU
00278685-		ID	GGACACA
ENST000		NO:
00615129-		1313
42
ENSG000	1.120167319	SEQ	ACCGGCAGCACC
00278707-		ID
ENST000		NO:
00610296-		1314
12
ENSG000	1.296134122	SEQ	AGCUCGGUCGCGGCUGCCUGUCUGCUCCGGCAGCAC
00278755-		ID	C
ENST000		NO:
00619424-		1315
37
ENSG000	1.511096092	SEQ	GAGAGACUACAACUCCCAGUAGUCACCGCG
00278848-		ID
ENST000		NO:
00617705-		1316
30
ENSG000	2.074341985	SEQ	CCGCCUGUCUGCACCGGCAGCACC
00278856-		ID
ENST000		NO:
00611567-		1317
24
ENSG000	1.371076129	SEQ	AGAGAUAGAGUCUUCCCUGGCAUUGCAGGAGAGAA
00281886-		ID	UCUGAAGGG
ENST000		NO:
00627547-		1318
44
ENSG000	1.89043467	SEQ	GCCUUAUCUGACUCUUGUUUUCAACAGAGUUUGUC
00281938-		ID	CUCUCACUUCUGGAGAAG
ENST000		NO:
00413683-		1319
53
ENSG000	1.323598894	SEQ	ACUCAGUGUACCUUCUAGUCCCGCC
00282019-		ID
ENST000		NO:
00633130-		1320
25
ENSG000	1.150959433	SEQ	UUAGUUCUUCCUGAGGUCUGAGCACCCUCCAAACUG
00282125-		ID	AGUCCAGAUCUGAGUUUUUCCUCGGAGAUUUGUCA
ENST000		NO:	GA
00632108-		1321
73
ENSG000	1.440297711	SEQ	AAAUUCAGGGUCCAGCUCACAGUGGAAAUACUUUC
00282223-		ID	UGAGAGUCAGUGACCUCCUGCACAAGAAC
ENST000		NO:
00631379-		1322
64
ENSG000	1.65030921	SEQ	AGCAUCAUCCAGAAACCACAUCCCUCCGCUAGAGAA
00282337-		ID	GCCCCUGACGGCACAGUUCCUCACU
ENST000		NO:
00632614-		1323
61
ENSG000	1.19630846	SEQ	UUUGCUCAGUUUCACAGAGGGCCUGGUCUGGAAUA
00282354-		ID	UUCCACAUCUGCUCUCACUCUGCC
ENST000		NO:
00631824-		1324
59
ENSG000	1.740603439	SEQ	GAAGGAAAGAGUAACUUGAGUUUCACUUCUUAGUG
00282628-		ID	CCUUUUCUCAGGGGAGAGGCCAUCACUUGAAG
ENST000		NO:
00634198-		1325
67
ENSG000	1.303791986	SEQ	AGUCUCCUUCACCACCCAGCUGGGAUCUCAGGGCUU
00282651-		ID	CCUUUUCUGUCCUCCUCCAGG
ENST000		NO:
00632950-		1326
57
ENSG000	1.280063899	SEQ	UCACCAAGUCACAGACCCAGAGGACCCCUCCAUCCU
00282719-		ID	GCAGUUCCUGCC
ENST000		NO:
00632016-		1327
48
ENSG000	1.580879837	SEQ	AUUCUUUCUUCAAAGCAGCC
00282812-		ID
ENST000		NO:
00619125-		1328
20
ENSG000	1.4862564	SEQ	CUUUCAAAGCCAAUUUGAAUAAACAACUCUUCCCUC
00283154-		ID	UCAAAGUGGCAAGAGUAACUCUUCAGCACC
ENST000		NO:
00412423-		1329
66
ENSG000	1.150959433	SEQ	UUAGUUCUUCCUGAGGUCUGAGCACCCUCCAAACUG
00283488-		ID	AGUCCAGAUCUGAGUUUUUCCUCGGAGAUUUGUCA
ENST000		NO:	GA
00636272-		1330
73
ENSG000	1.339719472	SEQ	AAGUUGCUUUGGUUUCUAUUACUUUGUUAAGUCAU
00284021-		ID	UCCUUCUGCAAAGGACUGCCUGGCAGGUGUCAAAG
ENST000		NO:	GCAGUGGUGGCCACAGAGGCGGUGGAGAG
00640356-		1331
99
ENSG000	1.276933056	SEQ	UGGUUUCUAUUACUUUGUUAAGUCAUUCCUUCUGC
00284021-		ID	AAAGGACUGCCUGGCAGGUGUCAAAGGCAGUGGUG
ENST000		NO:	GCCACAGAGGCGGUGGAGAG
00640466-		1332
90
ENSG000	1.282810866	SEQ	CUGGAGUCUCCGCGGGCAGAUCUCAUAUUUUGGAU
00284770-		ID	UCUGGAUAUAUUAUA
ENST000		NO:
00645662-		1333
50
ENSG000	1.102748702	SEQ	ACACCUUCUGAGGCAGCGGC
00284810-		ID
ENST000		NO:
00643904-		1334
20
ENSG000	1.950052408	SEQ	ACACACUCGCUUCUGGAACGUCUGAGGUUAUCAAU
00284931-		ID	AAGCUCCUAGUCCAGACGCC
ENST000		NO:
00642908-		1335
55
ENSG000	2.012761787	SEQ	CACACUCUGCCUUUGGACGUGAGAGAGAGCGCACCU
00285063-		ID	UUCACUUGAGCUUCAAC
ENST000		NO:
00644173-		1336
53
ENSG000	1.176135501	SEQ	ACAUAUCCACUCCUGCUCUCCCUCCUGCAGGUGACC
00285251-		ID	CCAGCC
ENST000		NO:
00647159-		1337
42
ENSG000	1.103341541	SEQ	UCAGGGCAGUAGAACAUAUUUUAAUCAAGUCCCCU
00285432-		ID	UGAUAAAAGAGCUUGAUUCCAGCUACUGCACUUCC
ENST000		NO:	UUCAUCAGCUCUCCACUG
00642785-		1338
88
ENSG000	1.211761788	SEQ	UUCGCAGCGGACCGAAGAGAAGAAAAGUAGGCCAG
00286070-		ID	AGCCGAACUCUCUUCCUGCCAAG
ENST000		NO:
00439775-		1339
58
ENSG000	1.344062718	SEQ	ACACUUUUGUGUGUGCUCUCAUUGCAA
00287080-		ID
ENST000		NO:
00612966-		1340
27
ENSG000	1.427199975	SEQ	ACCUCACCAUCAAGAAAGGCCCUGGUCCAGGAGUUG
00287363-		ID	CAAGGUGUGAGUAAAUCACAGGGCUGGGGAAGGUC
ENST000		NO:	AGCUCGGGGUCACAAGAAGCCUG
00372963-		1341
94
ENSG000	1.237967637	SEQ	CCGCUGAAGUGGAGCAGGUACAGUCACAGCUGUGG
00288362-		ID	GGACAGC
ENST000		NO:
00671845-		1342
42

Enumerated Embodiments

In some aspects, the present invention is directed to the following non-limiting embodiments:

Embodiment 1: A method of modulating a translational efficiency of a messenger RNA (mRNA) molecule, the method comprising: modifying a 5′-UTR of the mRNA molecule to include a translational enhancer or a translational silencer.

Embodiment 2: The method of Embodiment 1, wherein modifying the 5′-UTR of the mRNA molecule comprises modifying a sequence of a DNA molecule encoding the mRNA molecule.

Embodiment 3: The method of any one of Embodiments 1-2, wherein the translational enhancer or the translational silence is a translational enhancer or a translational silencer for the translational machinery of a yeast species, optionally a yeast species selected from the group consisting of Saccharomyces cerevisiae, Pichia pastoris, Hansenda polymorpha, Yarrowia lipolytica, Arxula adeninivorans, Kluyveromyces lactis, and Schizosaccharomyces pombe.

Embodiment 4: The method of Embodiment 3, wherein the 5′-UTR of the mRNA molecule is modified to include the translational enhancer, and wherein the translational enhancer includes at least one sequence selected from the group consisting of SEQ ID NOs: 1-3.

Embodiment 5: The method of Embodiment 3, wherein the 5′-UTR of the mRNA molecule is modified to include the translational silencer, and wherein the translational silencer includes at least one sequence selected from the group consisting of SEQ ID NOs: 4-6.

Embodiment 6: The method of any one of Embodiment 1-2, wherein the translational enhancer or the translational silence is a translational enhancer or a translational silencer for the translational machinery of a mammal, optionally a human.

Embodiment 7: The method of Embodiment 6, wherein the 5′-UTR of the mRNA molecule is modified to include the translational enhancer, and wherein the translational enhancer includes at least one sequence selected from the group consisting of SEQ ID NOs: 7-18, 29-51 and 56-1342.

Embodiment 8: The method of Embodiment 6, wherein the 5′-UTR of the mRNA molecule is modified to include the translational silencer, and wherein the translational silencer includes at least one sequence selected from the group consisting of SEQ ID NOs: 19-28.

Embodiment 9: The method of any one of Embodiment 1-8, wherein the 5′-UTR of the mRNA molecule is further modified to comprise a modified nucleobase.

Embodiment 10: The method of Embodiment 9, wherein the modified nucleobase comprises N6-methyladenosine, inosine, N1-propylpseudouridine, N1-methoxymethylpseudouridine, N1-ethylpseudouridine, 5-methoxycytidine, 5-hydroxyuridine, 5-carboxyuridine, 5-formyluridine, 5-hydroxycytidine, 5-hyrdoxymethylcytidine, 5-hydroxymethyluridine, 5-formylcytidine, 5-carboxycytidine, N4-methylcytidine, pseudoisocytidine, 2-thiocytidine, 4-thiocytidine, N1-methylpseudouridine, pseudouridine, 5-methyluridine, 5-methoxyuridine, dihydrouridine, 5-methylcytidine, 4-thiouridine, 2-thiouridine, uridine-5′-O-(1-thiophosphate), 5-aminoallyluridine, or 4-acetylcytidine.

Embodiment 11: The method of any one of Embodiment 1-10, wherein the 5′-UTR of the mRNA molecule is modified to include the translational enhancer, and wherein a ribosome retention score (RRS) of the modified mRNA molecule is 3× or higher than an RRS of the unmodified mRNA molecule.

Embodiment 12: The method of any one of Embodiments 1-10, wherein the 5′-UTR of the mRNA molecule is modified to include the translational silencer, and wherein a ribosome retention score (RRS) of the modified mRNA molecule is 0.3× or lower than an RRS of the unmodified mRNA molecule.

Embodiment 13: An mRNA molecule comprising a 5′-UTR, wherein the 5′-UTR comprises: a translational enhancer comprising at least one sequence selected from the group consisting of SEQ ID NOs: 1-3, 7-18, 29-51 and 56-1342, or a translational silencer comprising at least one selected from the group consisting of SEQ ID NOs: 4-6 and 19-28; and a modified nucleobase.

Embodiment 14: The mRNA molecule of Embodiment 13, wherein the modified nucleobase comprises N6-methyladenosine, inosine, N1-propylpseudouridine, N1-methoxymethylpseudouridine, N1-ethylpseudouridine, 5-methoxycytidine, 5-hydroxyuridine, 5-carboxyuridine, 5-formyluridine, 5-hydroxycytidine, 5-hyrdoxymethylcytidine, 5-hydroxymethyluridine, 5-formylcytidine, 5-carboxycytidine, N4-methylcytidine, pseudoisocytidine, 2-thiocytidine, 4-thiocytidine, N1-methylpseudouridine, pseudouridine, 5-methyluridine, 5-methoxyuridine, dihydrouridine, 5-methylcytidine, 4-thiouridine, 2-thiouridine, uridine-5′-O-(1-thiophosphate), 5-aminoallyluridine, or 4-acetylcytidine.

Embodiment 15: The mRNA molecule of any of Embodiments 13-14, wherein the 5′-UTR comprises the translational enhancer, and wherein a ribosome retention score (RRS) of the mRNA molecule is 3× or higher than an RRS of an mRNA molecule that does not comprise the translational enhancer or the modified nucleobase but otherwise has the same sequence.

Embodiment 16: The mRNA molecule of any of Embodiments 13-15, wherein the 5′-UTR comprises at least one sequences selected from the group consisting of SEQ ID NOs: 29-50.

Embodiment 17: The mRNA molecule of any of Embodiment 13-14, wherein the 5′-UTR comprises the translational silencer, and wherein an RRS of the mRNA molecule is 0.3× or lower than an RRS of an mRNA molecule that does not comprise the translational silencer or the modified nucleobase but otherwise has the same sequence.

Embodiment 18: The mRNA molecule of any one of Embodiment 13-17, wherein the mRNA molecule encodes a therapeutic peptide or a therapeutic protein.

Embodiment 19: The mRNA molecule of Embodiment 18, wherein the therapeutic peptide or the therapeutic protein comprises a vaccine.

Embodiment 20: A method of constructing an mRNA molecule for producing a therapeutic peptide or a therapeutic protein, the method comprising including a translational enhancer at a 5′ UTR to the 5′ side of a coding region encoding the therapeutic peptide or a therapeutic protein.

Embodiment 21: The method of Embodiment 20, wherein the therapeutic peptide or a therapeutic protein comprises a vaccine.

Embodiment 22: A yeast cell for expressing a protein, comprising an mRNA molecule or a nucleotide encoding the mRNA molecule, wherein the mRNA molecule comprises: a 5′-UTR comprising at least one yeast translational enhancer; and a coding region encoding the protein, or a coding region for introducing a nucleotide sequence for encoding the protein.

Embodiment 23: The yeast cell of Embodiment 22, wherein the 5′-UTR comprises at least one sequence selected from the group consisting of SEQ ID NOs: 1-3.

Embodiment 24: The yeast of any one of Embodiment 22-23, wherein the yeast cell is a Saccharomyces cerevisiae cell, a Pichia pastoris cell, a Hansenula polymorpha cell, a Yarrowia lipolytica cell, an Arxula adeninivorans cell, a Kluyveromyces lactis cell, or a Schizosaccharomyces pombe cell.

The foregoing outlines features of several embodiments so that those skilled in the art may better understand the aspects of the present disclosure. Those skilled in the art should appreciate that they may readily use the present disclosure as a basis for designing or modifying other processes and structures for carrying out the same purposes and/or achieving the same advantages of the embodiments introduced herein. Those skilled in the art should also realize that such equivalent constructions do not depart from the spirit and scope of the present disclosure, and that they may make various changes, substitutions, and alterations herein without departing from the spirit and scope of the present disclosure.

Claims

1. A method of modulating a translational efficiency of a messenger RNA (mRNA) molecule, the method comprising: modifying a 5′-UTR of the mRNA molecule to include a translational enhancer or a translational silencer.

2. The method of claim 1, wherein modifying the 5′-UTR of the mRNA molecule comprises modifying a sequence of a DNA molecule encoding the mRNA molecule.

3. The method of claim 1, wherein the translational enhancer or the translational silencer is a translational enhancer or a translational silencer for the translational machinery of a yeast species, optionally a yeast species selected from the group consisting of Saccharomyces cerevisiae, Pichia pastoris, Hansenula polymorpha, Yarrowia lipolytica, Arxula adeninivorans, Kluyveromyces lactis, and Schizosaccharomyces pombe.

4. The method of claim 3, wherein the 5′-UTR of the mRNA molecule is modified to include the translational enhancer, and wherein the translational enhancer includes at least one sequence selected from the group consisting of SEQ ID NOs: 1-3.

5. The method of claim 3, wherein the 5′-UTR of the mRNA molecule is modified to include the translational silencer, and wherein the translational silencer includes at least one sequence selected from the group consisting of SEQ ID NOs: 4-6.

6. The method of claim 1, wherein the translational enhancer or the translational silence is a translational enhancer or a translational silencer for the translational machinery of a mammal, optionally a human.

7. The method of claim 6, wherein the 5′-UTR of the mRNA molecule is modified to include the translational enhancer, and wherein the translational enhancer includes at least one sequence selected from the group consisting of SEQ ID NOs: 7-18, 29-51 and 56-1342.

8. The method of claim 6, wherein the 5′-UTR of the mRNA molecule is modified to include the translational silencer, and wherein the translational silencer includes at least one sequence selected from the group consisting of SEQ ID NOs: 19-28.

9. The method of claim 1, wherein the 5′-UTR of the mRNA molecule is further modified to comprise a modified nucleobase.

10. The method of claim 9, wherein the modified nucleobase comprises N6-methyladenosine, inosine, N1-propylpseudouridine, N1-methoxymethylpseudouridine, N1-ethylpseudouridine, 5-methoxycytidine, 5-hydroxyuridine, 5-carboxyuridine, 5-formyluridine, 5-hydroxycytidine, 5-hyrdoxymethylcytidine, 5-hydroxymethyluridine, 5-formylcytidine, 5-carboxycytidine, N4-methylcytidine, pseudoisocytidine, 2-thiocytidine, 4-thiocytidine, N1-methylpseudouridine, pseudouridine, 5-methyluridine, 5-methoxyuridine, dihydrouridine, 5-methylcytidine, 4-thiouridine, 2-thiouridine, uridine-5′-O-(1-thiophosphate), 5-aminoallyluridine, or 4-acetylcytidine.

11. The method of claim 1, wherein the 5′-UTR of the mRNA molecule is modified to include the translational enhancer, and wherein a ribosome retention score (RRS) of the modified mRNA molecule is 3× or higher than an RRS of the unmodified mRNA molecule.

12. The method of claim 1, wherein the 5′-UTR of the mRNA molecule is modified to include the translational silencer, and wherein a ribosome retention score (RRS) of the modified mRNA molecule is 0.3× or lower than an RRS of the unmodified mRNA molecule.

13. An mRNA molecule comprising a 5′-UTR, wherein the 5′-UTR comprises: a translational enhancer comprising at least one sequence selected from the group consisting of SEQ ID NOs: 1-3, 7-18, 29-51 and 56-1342, or a translational silencer comprising at least one selected from the group consisting of SEQ ID NOs: 4-6 and 19-28; anda modified nucleobase.

14. The mRNA molecule of claim 13, wherein the modified nucleobase comprises N6-methyladenosine, inosine, N1-propylpseudouridine, N1-methoxymethylpseudouridine, N1-ethylpseudouridine, 5-methoxycytidine, 5-hydroxyuridine, 5-carboxyuridine, 5-formyluridine, 5-hydroxycytidine, 5-hyrdoxymethylcytidine, 5-hydroxymethyluridine, 5-formylcytidine, 5-carboxycytidine, N4-methylcytidine, pseudoisocytidine, 2-thiocytidine, 4-thiocytidine, N1-methylpseudouridine, pseudouridine, 5-methyluridine, 5-methoxyuridine, dihydrouridine, 5-methylcytidine, 4-thiouridine, 2-thiouridine, uridine-5′-O-(1-thiophosphate), 5-aminoallyluridine, or 4-acetylcytidine.

15. The mRNA molecule of claim 13, wherein the 5′-UTR comprises the translational enhancer, and wherein a ribosome retention score (RRS) of the mRNA molecule is 3× or higher than an RRS of an mRNA molecule that does not comprise the translational enhancer or the modified nucleobase but otherwise has the same sequence.

16. The mRNA molecule of claim 13, wherein the 5′-UTR comprises at least one sequences selected from the group consisting of SEQ ID NOs: 29-50.

17. The mRNA molecule of claim 13, wherein the 5′-UTR comprises the translational silencer, and wherein an RRS of the mRNA molecule is 0.3× or lower than an RRS of an mRNA molecule that does not comprise the translational silencer or the modified nucleobase but otherwise has the same sequence.

18. The mRNA molecule of claim 13, wherein the mRNA molecule encodes a therapeutic peptide or a therapeutic protein.

19. The mRNA molecule of claim 18, wherein the therapeutic peptide or the therapeutic protein comprises a vaccine.

20. A method of constructing an mRNA molecule for producing a therapeutic peptide or a therapeutic protein, the method comprising including a translational enhancer at a 5′ UTR to the 5′ side of a coding region encoding the therapeutic peptide or a therapeutic protein.

21. The method of claim 20, wherein the therapeutic peptide or a therapeutic protein comprises a vaccine.

22. A yeast cell for expressing a protein, comprising an mRNA molecule or a nucleotide encoding the mRNA molecule, wherein the mRNA molecule comprises: a 5′-UTR comprising at least one yeast translational enhancer; anda coding region encoding the protein, or a coding region for introducing a nucleotide sequence for encoding the protein.

23. The yeast cell of claim 22, wherein the 5′-UTR comprises at least one sequence selected from the group consisting of SEQ ID NOs: 1-3.

24. The yeast of claim 22, wherein the yeast cell is a Saccharomyces cerevisiae cell, a Pichia pastoris cell, a Hansenula polymorpha cell, a Yarrowia lipolytica cell, an Arxula adeninivorans cell, a Kluyveromyces lactis cell, or a Schizosaccharomyces pombe cell.