Method of operating a laboratory sample distribution system, laboratory sample distribution system and laboratory automation system

Information

  • Patent Grant
  • 10509049
  • Patent Number
    10,509,049
  • Date Filed
    Friday, March 10, 2017
    7 years ago
  • Date Issued
    Tuesday, December 17, 2019
    4 years ago
Abstract
A method of operating a laboratory sample distribution system is presented. The method comprises a number of sample container carriers on a transport plane by a number of electro-magnetic actuators. The method is adapted to compensate deviations regarding physical properties of the sample container carriers, the transport plane and the electro-magnetic actuators compared to reference components. A laboratory automation system comprising such a laboratory sample distribution system is also presented.
Description
BACKGROUND

The present disclosure relates to a method of operating a laboratory sample distribution system, a laboratory sample distribution system and a laboratory automation system.


Known laboratory sample distribution systems are typically used in laboratory automation systems in order to distribute samples contained in sample containers between different laboratory stations. A typical laboratory sample distribution system can provide high throughput and reliable operation.


However, there is a need for a method of operating a laboratory sample distribution system that provides reliable, long term operation.


SUMMARY

According to the present disclosure, a method of operating a laboratory sample distribution system is disclosed. The laboratory sample distribution system can comprise a number of sample container carriers. The sample container carriers can each comprise at least one magnetically active device and can be adapted to carry at least one sample container. The laboratory sample distribution system can also comprise a transport plane adapted to support the sample container carriers and a number of electro-magnetic actuators stationary arranged below the transport plane. The electro-magnetic actuators can be adapted to move a corresponding sample container carrier on top of the transport plane by applying a magnetic force to the sample container carrier. The method can comprise activating one of the number electro-magnetic actuators to apply a magnetic force to one of the number of sample container carriers in order to cause a movement of the one sample container carrier, detecting an electro-magnetic actuator calibration movement profile of the one sample container carrier, determining at least one electro-magnetic actuator calibration parameter for the one electro-magnetic actuator in response to the electro-magnetic actuator calibration movement profile, and operating the one electro-magnetic actuator according to the at least one determined electro-magnetic actuator calibration parameter, when the one electro-magnetic actuator is activated a next time.


Accordingly, it is a feature of the embodiments of the present disclosure to provide a method of operating a laboratory sample distribution system that provides for a reliable long term operation. Other features of the embodiments of the present disclosure will be apparent in light of the description of the disclosure embodied herein.





BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS

The following detailed description of specific embodiments of the present disclosure can be best understood when read in conjunction with the following drawings, where like structure is indicated with like reference numerals and in which:



FIG. 1 illustrates a laboratory automation system comprising a laboratory sample distribution system according to an embodiment of the present disclosure.



FIG. 2 illustrates a method of operating the laboratory automation system of FIG. 1 according to an embodiment of the present disclosure.





DETAILED DESCRIPTION

In the following detailed description of the embodiments, reference is made to the accompanying drawings that form a part hereof, and in which are shown by way of illustration, and not by way of limitation, specific embodiments in which the disclosure may be practiced. It is to be understood that other embodiments may be utilized and that logical, mechanical and electrical changes may be made without departing from the spirit and scope of the present disclosure.


A method of operating a laboratory sample distribution system is disclosed. The laboratory sample distribution system can comprise a number of sample container carriers. Each sample container carrier can comprise at least one magnetically active device. Each sample container carrier can be adapted to carry at least one sample container. The laboratory sample distribution system can further comprise a transport plane adapted to support or carry the sample container carriers. The laboratory sample distribution system can further comprise a number of electro-magnetic actuators. The electro-magnetic actuators can be stationary arranged below the transport plane and can be adapted to move a corresponding sample container carrier on top of the transport plane by applying a magnetic force to the sample container carrier.


The method can comprise the step a) of activating one or more of the number of electro-magnetic actuators to apply or exert or cause a magnetic force to one of the number of sample container carriers in order to induce a movement of the one sample container carrier. The method can further comprise the step b) of detecting an electro-magnetic actuator calibration movement profile of the one sample container carrier. The method can further comprise the step c) of determining at least one electro-magnetic actuator calibration parameter for the one electro-magnetic actuator in response to the electro-magnetic actuator calibration movement profile. The method can further comprise the step d) of operating the one electro-magnetic actuator according to the at least one determined electro-magnetic actuator calibration parameter.


A magnetic field strength of the one electro-magnetic actuator may deviate from a reference magnetic field strength of a reference or “normal” electro-magnetic actuator or from an average magnetic field strength of the rest of electro-magnetic actuators, in particular a selection of electro-magnetic actuators. If the electrical resistance of the one electro-magnetic actuator differs from the electrical resistance of the reference electro-magnetic actuator, a current flow caused by a driving voltage through the one electro-magnetic actuator may deviate from a current flow caused by a similar driving voltage through the reference electro-magnetic actuator and hence the magnetic fields generated by the respective current flows may differ. Reasons for this may be for example assembly margins, wear or damage. Additionally, surface properties of a local area of the transport plane, wherein the one electro-magnetic actuator can be arranged below the local area, may deviate from reference or “normal” surface properties of a reference local area. Surface properties can be for example a surface roughness of the local area or material on the local area. Reasons for this may be for example assembly margins, wear, damage, environment and dirt like a spilt sample. A magnetic field strength deviation of the one electro-magnetic actuator and surface properties deviations of the local area may cause a deviation of the movement of the one sample container carrier compared to a reference or “normal” movement. This may render the laboratory sample distribution system itself unreliable or it may limit the maximum driving potential of the laboratory sample distribution system. Alternatively or additionally, it may help to distinguish components of the laboratory sample distribution system, that may be replaced soon e.g. due to abrasion.


By the method of operating the laboratory sample distribution system, it can be possible to compensate deviations regarding physical properties of components of the laboratory sample distribution system, i.e. a magnetic field strength deviation of the one electro-magnetic actuator and surface properties deviations of the local area, without using an external inspection probe adapted for measurements of the physical properties. Hence, the one sample container carrier may be moved on the local area by the one electro-magnetic actuator according to the optimum target movement. Thus, for example, irregularities in a ride of the one sample container carrier may be prevented, which could otherwise cause a disruption in the operation of the laboratory sample distribution system. Hence, a maximum reliability and uptime of the laboratory sample distribution system can be ensured. The method may be performed, or executed, at startup of the laboratory sample distribution system and/or at intervals e.g. once a day. A measurement of the named properties with the external inspection probe may in some cases even not be possible, because the laboratory sample distribution system may be covered and hence not easily accessible. Additionally, such an inspection may require shutting down the laboratory sample distribution system at least partially.


The sample containers can typically be designed as tubes made of glass or transparent plastic and typically can have an opening at an upper end. The sample containers can be used to contain, store and transport samples such as blood samples or chemical samples. The transport plane can also be denoted as transport surface. The transport plane can support the sample container carriers, what can also be denoted as carrying the sample container carriers. The electro-magnetic actuators can typically be solenoids surrounding ferromagnetic cores. These electro-magnetic actuators may be energized in order to provide a magnetic field that can be used to move or drive the sample container carriers. For that purpose, the at least one magnetically active device in each sample container carrier may be a permanent magnet. Alternatively or additionally, an electro-magnet and/or any magnetically soft material can be used. The sample container carriers can typically be adapted to move in two dimensions on the transport plane. For that purpose, the electro-magnetic actuators may be arranged in two dimensions below the transport plane. The electro-magnetic actuators may be arranged in a grid or matrix having rows and columns along which the electro-magnetic actuators can be arranged.


The one sample container carrier, to which the magnetic force is applied in step a), can be within an operating distance of the one electro-magnetic actuator of interest, in order to induce a movement of the one sample container carrier. Activating the one electro-magnetic actuator can mean that a magnetic field can be generated by the one electro-magnetic actuator. Activating may be done by supplying a driving voltage from an electric power supply to the solenoid surrounding the ferromagnetic core. The electro-magnetic actuator calibration movement profile of the one sample container carrier in step b) can be a position (x/y) or a speed and a direction of the one sample container carrier over time, detected in order to determine the at least one electro-magnetic actuator calibration parameter for the one electro-magnetic actuator in step c). The position of the one sample container carrier may be detected by a plurality of sensors, e.g. Hall-sensors, of a control unit, the plurality of Hall-sensors arranged in a grid or matrix having rows and columns and each adapted to sense the presence of the at least one magnetically active device of the one sample container carrier. From the known position of the Hall-sensor, above which the one sample container carrier can be located, the position of the one sample container carrier may be deduced. Additionally or alternatively, the position of the one sample container carrier may be detected by a camera or another kind of sensor like an optical sensor of the control unit. Determining the at least one electro-magnetic actuator calibration parameter for the one electro-magnetic actuator in response to the electro-magnetic actuator calibration movement profile of the one sample container carrier in step c) may comprise comparing the electro-magnetic actuator calibration movement profile to a reference electro-magnetic actuator calibration movement profile for the one sample container carrier, e.g. a movement profile of the one sample container carrier caused by a reference electro-magnetic actuator measured in the past at a manufacturer's site. According to the at least one determined electro-magnetic actuator calibration parameter, the one electro-magnetic actuator can be operated in step d), when the one electro-magnetic actuator can be activated a next time, that can be in the following or consecutive activations, to apply a magnetic force to the one sample container carrier in order to induce a movement of the one sample container carrier. Hence, a magnetic field strength deviation of the one electro-magnetic actuator and surface properties deviations of the local area may be compensated.


The steps a) to d) can be performed or executed in the mentioned order. However, the determination of the at least one electro-magnetic actuator calibration parameter may be done in real-time, while the one sample container carrier is still moving, e.g. while the one sample container carrier is attracted by the one electro-magnetic actuator. When the one sample container is above the one electro-magnetic actuator, the polarity of the magnetic field caused by the one electro-magnetic actuator may be reversed and for a magnitude of a reversed driving voltage the at least one electro-magnetic actuator calibration parameter may be already considered.


The method may comprise the steps of storing the at least one electro-magnetic actuator calibration parameter for the one electro-magnetic actuator in a software of the control unit of the laboratory sample distribution system after step c) and reading the at least one electro-magnetic actuator calibration parameter before step d).


According to an embodiment, the steps a) to d) can be executed or repeated or performed for each of the number of electro-magnetic actuators. For example, the number of electro-magnetic actuators may differ from each other in their magnetic strength and a number of local areas of the transport plane may differ from each other in their surface properties. Each of the number of local areas can be allocated to a particular electro-magnetic actuator of the number of electro-magnetic actuators arranged below the respective local area. Differences between the magnetic field strength of the number of electro-magnetic actuators and differences between the surface properties of the number of local areas of the transport plane may be compensated, such that the one sample container carrier may be smoothly moved on the transport plane, no matter on which local area the one sample container carrier is located or positioned or moving.


According to an embodiment, the at least one electro-magnetic actuator calibration parameter can comprise a first electric power supply parameter of the one electro-magnetic actuator. In step d), the one electro-magnetic actuator can be supplied with electric power according to the first electric power supply parameter. The first electric power supply parameter may comprise or be incorporated as a magnitude of the driving voltage used to supply the one electro-magnetic actuator with electric power. Additionally or alternatively, the first electric power supply parameter may comprise or be incorporated as a potentiometer ratio of an adjustable potentiometer interconnected in between the electro-magnetic actuator and the power supply.


According to an embodiment, the at least one electro-magnetic actuator calibration parameter can comprise a first activating time duration parameter of the one electro-magnetic actuator and in step d), the one electro-magnetic actuator can be activated according to the first activating time duration parameter. The electric power supply may not have to be adjusted or may not be adjustable. In this case, a duration, during which the one electro-magnetic actuator can be activated, and hence the time duration, during which a magnetic force can be applied to the one sample container carrier, can be adjusted according to the first activating time duration parameter.


According to an embodiment, the method can comprise the step of disqualifying the one electro-magnetic actuator, if the at least one electro-magnetic actuator calibration parameter exceeds a specified electro-magnetic actuator parameter threshold value and/or if a change of the at least one electro-magnetic actuator calibration parameter between at least two consecutive executions or performances of the steps a) to c) exceeds a specified electro-magnetic actuator parameter change limit. The electro-magnetic actuator parameter threshold value may be an upper threshold value or a lower threshold value. Alternatively, an upper threshold value and a lower threshold value may define an electro-magnetic actuator parameter range. The one electro-magnetic actuator can be disqualified, if the at least one electro-magnetic actuator calibration parameter is outside of the electro-magnetic actuator calibration parameter range. A too high, too low or strongly changing electro-magnetic actuator calibration parameter can be an indication of a problem with the one electro-magnetic actuator or the local area, e.g. the one electro-magnetic actuator or its electric power supply may be going defect or the local area may be polluted, e.g. by spilled liquid from a liquid sample. Hence, the problem may be detected before the operation of the laboratory sample distribution system gets interrupted by the problem.


According to an embodiment, the method can comprise the following steps during operating the one electro-magnetic actuator according to step d): e) detecting a sample container carrier calibration movement profile of one of the number of sample container carriers, f) determining at least one sample container carrier calibration parameter for the one sample container carrier in response to the sample container carrier calibration movement profile, and g) operating the one electro-magnetic actuator according to the at least one determined electro-magnetic actuator calibration parameter and additionally to the at least one determined sample container carrier calibration parameter. The steps e) to f) can be performed or executed in the mentioned order. The sample container carrier calibration movement profile of the one sample container carrier in step e) can be a position or a speed and a direction of the one sample container carrier over time, detected in order to determine the at least one sample container carrier calibration parameter for the sample container carrier in step f).


Not only may the magnetic field strength of each of the number of electro-magnetic actuators and the surface properties of each of the number of local areas deviate from respective target values, also, the magnetic field strength of the at least one magnetically active device of each of the number of sample container carriers may deviate from a target magnetic field strength. Additionally, surface properties of a glide surface, with which each of the number of sample container carriers touches the transport plane, may deviate from target surface properties. After each of the number of electro-magnetic actuators at least one electro-magnetic actuator calibration parameter has been determined, for example, by the use of a particular reference sample container carrier, the steps e) to f) may be performed for all other sample container carriers of the number of sample container carriers. The steps e) to f) may be performed for sample container carriers that do not carry sample containers at that time, whereby the sample container carriers can be in a defined state, because different sample containers may have different weights. In case the at least one magnetically active device is an electro-magnet, in step g) additionally or alternatively, the electro-magnet may be operated according to the at least one determined sample container carrier calibration parameter. Hence, the one sample container carrier may be moved on the local area by the one electro-magnetic actuator according to the optimum target movement. Some of the sample container carriers can be removed from the laboratory sample distribution system for an external inspection, but this can mean that they may not be available during the time of the inspection and hence the number of sample container carriers had to be increased to compensate the missing ones.


The method may comprise the steps of storing the at least one sample container carrier calibration parameter of each of the number of sample container carriers in the software of the control unit of the laboratory sample distribution system after step f) and reading the at least sample container carrier calibration parameter before step g). According to an embodiment, each of the number of sample container carriers can comprise a sample container carrier calibration parameter memory unit and the method can comprise the steps of storing the at least one sample container carrier calibration parameter of each of the number of sample container carriers on the corresponding sample container carrier calibration parameter memory unit and reading the at least one sample container carrier calibration parameter from the sample container carrier calibration parameter memory unit. These two steps may be performed after step f) and before step g). The sample container carrier calibration parameter memory unit may be a non-volatile memory device. Hence, it can be possible to take a particular sample container carrier out of the laboratory sample distribution system and to put it into another, similar laboratory sample distribution system without losing the at least one sample container carrier calibration parameter for the particular sample container carrier and not having to perform the steps e) to f) again. Advantageously, each of the number of sample container carriers can comprise a receiving and sending unit and the control unit can comprise a receiving and sending unit in order to store the at least one sample container carrier calibration parameters on the sample container carriers and to read them from the sample container carriers.


According to an embodiment, the at least one sample container carrier calibration parameter can comprise a second electric power supply parameter of the one electro-magnetic actuator and, in step g), the electro-magnetic actuator can be supplied with electric power according to the second electric power supply parameter.


According to an embodiment, the at least one sample container carrier calibration parameter can comprise a second activating time duration parameter of the one electro-magnetic actuator and, in step g), the electro-magnetic actuator can be supplied with electric power according to the second activating time duration parameter.


According to an embodiment, the method can comprise the step of disqualifying the one sample container carrier, if the at least one sample container carrier calibration parameter exceeds a specified sample container carrier parameter threshold value and/or if a change of the at least one sample container carrier calibration parameter between at least two consecutive executions or performances of the steps e) to f) exceeds a specified sample container carrier parameter change limit. The sample container carrier threshold value may be an upper threshold value or a lower threshold value. Alternatively, an upper threshold value and a lower threshold value may define a sample container carrier parameter range. The one sample container carrier can be disqualified, if the at least one sample container carrier calibration parameter is outside of the sample container carrier calibration parameter range. A too high, too low or strongly changing sample container carrier calibration parameter is an indication of a problem with the one sample container carrier, e.g. the at least one magnetically active device may be defect or on the glide surface a liquid sample may be spilt, polluting the glide surface. Hence, the problem may be detected, before the operation of the laboratory sample distribution system gets interrupted by the problem.


A laboratory sample distribution system adapted to perform the method as described above is presented. The laboratory sample distribution system can comprise a number of sample container carriers. The sample container carriers can each comprise at least one magnetically active device such as, for example, at least one permanent magnet, and adapted to carry at least one sample container. The laboratory sample distribution system can also comprise a transport plane adapted to support said sample container carriers and a number of electro-magnetic actuators stationary arranged below the transport plane. The electro-magnetic actuators can be adapted to move a corresponding sample container carrier on top of the transport plane by applying a magnetic force to the sample container carrier. The laboratory sample distribution system can also comprise a control unit. The control unit can be adapted to activate one of the number of electro-magnetic actuators to apply a magnetic force to one of the number of sample container carriers in order to cause a movement of the one sample container carrier, to detect an electro-magnetic actuator calibration movement profile of the one sample container carrier, to determine at least one electro-magnetic actuator calibration parameter for the one electro-magnetic actuator in response to the electro-magnetic actuator calibration movement profile and to operate the one electro-magnetic actuator according to the at least one determined electro-magnetic actuator calibration parameter. Additionally, during operating the one electro-magnetic actuator according to the at least one determined electro-magnetic actuator calibration parameter, the control unit may be adapted to detect a sample container carrier calibration movement profile of one of the number of sample container carriers, to determine at least one sample container carrier calibration parameter for the one sample container carrier in response to the sample container carrier calibration movement profile and to operate the one electro-magnetic actuator according to the at least one determined sample container carrier calibration parameter. The control unit may further be adapted to disqualify the one electro-magnetic actuator and the one sample container carrier. Hence, the method can be automatically controlled by the control unit in a comfortable, fast and fail-safe manner. Additionally, the control unit can be capable of controlling several steps of several electro-magnetic actuators and several sample container carriers at a time.


In one embodiment, each of the number of sample container carriers can comprise a sample container carrier calibration parameter memory unit for the at least one sample container carrier calibration parameter. Advantageously, each of the number of sample container carriers can comprise a receiving and sending unit and the control unit can comprise a receiving and sending unit in order to store the at least one sample container carrier calibration parameters on the sample container carriers and to read them from the sample container carriers.


A laboratory automation system is also presented. The laboratory automation system can comprise a number of a pre-analytical, analytical and/or post-analytical laboratory stations and a laboratory sample distribution system as described above adapted to distribute the sample container carriers and/or sample containers between the laboratory stations.


The laboratory stations may be arranged adjacent to the laboratory sample distribution system. Pre-analytical stations may be adapted to perform any kind of pre-processing of samples, sample containers and/or sample container carriers. Analytical stations may be adapted to use a sample or part of the sample and a reagent to generate a measuring signal, the measuring signal indicating if and in which concentration, if any, an analyte exists. Post-analytical stations may be adapted to perform any kind of post-processing of samples, sample containers and/or sample container carriers. The pre-analytical, analytical and/or post-analytical stations may comprise at least one of a decapping station, a recapping station, an aliquot station, a centrifugation station, an archiving station, a pipetting station, a sorting station, a tube type identification station, a sample quality determining station, an add-on buffer station, a liquid level detection station, and a sealing/desealing station.


Referring initially to FIG. 1, FIG. 1 shows a laboratory automation system 10 comprising a laboratory sample distribution system 100 and a number of pre-analytical, analytical and/or post-analytical laboratory stations 20 arranged adjacent to the laboratory sample distribution system 100. Self-evidently, more than the two laboratory stations 20 depicted in FIG. 1 may be comprised in the laboratory automation system 10.


The laboratory sample distribution system 100 can comprise a transport plane 110, under which a plurality of electro-magnetic actuators 120, 120′, 120″ can be positioned. The electro-magnetic actuators 120, 120′, 120″ can be implemented as solenoids having a solid ferromagnetic core 125. The electro-magnetic actuators 120, 120′, 120″ can be quadratically arranged in a grid or matrix having rows and columns. In each center of a quadrat formed by corresponding electro-magnetic actuators 120, 120′, 120″ no electro-magnetic actuator may be arranged. The transport plane can be divided in local areas 300. Under each local area 300, one of the electro-magnetic actuators 120, 120′, 120″ can be arranged, except for a selection of local areas 300, which can be arranged above the center of the quadrats formed by the corresponding electro-magnetic actuators 120, 120′, 120″.


Sample container carriers 140, 140′, 140″ can be positioned on the transport plane 110 and can be moved by the electro-magnetic actuators 120, 120′, 120″ on individual transport paths. While it can be understood that a plurality of sample container carriers 140, 140′, 140″ can be positioned on the transport plane 110, due to simplicity only three sample container carriers 140, 140′, 140″ are depicted in FIG. 1. The sample container carrier 140 can hold a sample container 145, in which a sample to be analyzed may be contained. Each of the sample container carriers 140, 140′, 140″ can comprise a not-shown permanent magnet.


The laboratory sample distribution system 100 can be adapted to distribute the sample container carriers 140, 140′, 140″ and/or the sample containers 145 between the laboratory stations 20. The laboratory stations 20 can be positioned adjacent to the transport plane 110 such that a sample container carrier 140, 140′, 140″ can be used to transport a sample contained in the sample container 145 to a respective laboratory station 20.


The laboratory sample distribution system 100 can further comprise a control unit 150. The control unit 150 can be configured to control movements of the sample container carriers 140, 140′, 140″ on the transport plane by activating and controlling the electro-magnetic actuators 120, 120′, 120″ such that the sample container carriers 140, 140′, 140″ independently and simultaneously can move along corresponding transport paths.


A plurality of Hall-sensors 130 can be arranged such that positions of respective sample container carriers 140, 140′, 140″ on the transport surface 110 can be detected.


Sample container carrier 140′ can be a reference sample container carrier. A reference electro-magnetic actuator calibration movement profile and a reference sample container carrier calibration movement profile has been determined for the reference sample container carrier 140′ caused by reference electro-magnetic actuators arranged below a reference transport plane measured in the past at a manufacturer's site.


In FIG. 1, the reference sample container carrier 140′ can be successively attracted by the electro-magnetic actuators 120, 120′ arranged below the left part of the transport plane 110 and hence moved downwards in FIG. 1 as denoted by the arrow 200. This action can correspond to step a) in FIG. 2. For the electro-magnetic actuators 120, 120′ arranged below the left part of the transport plane 110, no electro-magnetic actuator calibration parameters have been determined until then. The position of the reference sample container carrier 140′ can be detected by the Hall-sensors 130. The position over time and hence the electro-magnetic actuator calibration movement profile of the reference sample container carrier 140′ can be detected by the control unit 150. This action can correspond to step b) in FIG. 2. The control unit 150 can compare the electro-magnetic actuator calibration movement profile of the reference sample container carrier 140′ to the target electro-magnetic actuator calibration movement profile and determines electro-magnetic actuator calibration parameters for the electro-magnetic actuators 120, 120′ arranged below the left part of the transport plane 110. This action can correspond to step c) in FIG. 2.


The determined electro-magnetic actuator calibration parameters for the electro-magnetic actuators 120, 120′ arranged below the left part of the transport plane 110 can be stored in a non-volatile storage of the control unit 150. When the electro-magnetic actuators 120, 120′ are activated a next time, the electro-magnetic actuator calibration parameters can be read and the electro-magnetic actuators 120, 120′ can be operated accordingly. This action can correspond to step d) in FIG. 2.


For example, the magnetic field of the electro-magnetic actuator 120′ next to the reference sample container carrier 140′ may be lower than a target magnetic field of the reference electro-magnetic actuators, and hence the reference sample container carrier 140′ can be attracted by a magnetic force smaller than a reference magnetic force. Hence, the reference sample container carrier 140′ may arrive later in time above the electro-magnetic actuator 120′ than scheduled for a strong enough magnetic field of the electro-magnetic actuator 120′. From the deviation in time, the electro-magnetic actuator calibration parameter can be deduced. In this case, the electro-magnetic actuator calibration parameter can comprise a first electric power supply parameter. The electro-magnetic actuator 120′ in FIG. 1 can be activated by supplying a default driving voltage from a not-shown electric power supply. If the magnetic field of the electro-magnetic actuator 120′ were similar to the target magnetic field, the first electric power supply parameter can be one. Since the magnetic field of the electro-magnetic actuator 120′ is lower than desired, the first electric power supply parameter can have a value larger than one, i.e. when the electro-magnetic actuator 120′ is activated a next time, the electro-magnetic actuator calibration parameter can be read and the electro-magnetic actuator 120′ can be supplied with the default driving voltage multiplied by the first electric power supply parameter, a current flow through the electro-magnetic actuator 120′ can be larger and hence the magnetic field of the electro-magnetic actuator 120′ can be larger.


If a value of one of the determined electro-magnetic actuator calibration parameters for the electro-magnetic actuators 120, 120′ arranged below the left part of the transport plane 110 exceeds a specified electro-magnetic actuator parameter threshold value, e.g. the value two, the corresponding electro-magnetic actuator 120, 120′ can be disqualified. This step can be optional as indicated by a dashed arrow in FIG. 2. For example, the control unit 150 can report an error message about the particular one electro-magnetic actuator 120, 120′ to a human operator of the laboratory automation system 10.


For the electro-magnetic actuators 120, 120″ arranged below the middle part and right part of the transport plane 110, electro-magnetic actuator calibration parameters have already been determined. However, for the sample container carrier 140″ positioned in the middle part of the transport plane 110 no sample container carrier calibration parameter has been determined until then. The sample container carrier 140″ can be successively attracted by the electro-magnetic actuators 120, 120″ arranged below the middle part of the transport plane 110 and hence moved downwards in FIG. 1 as denoted by the arrow 210. Thereby, the electro-magnetic actuators 120, 120″ arranged below the middle part of the transport plane 110 can be operated according to their already determined electro-magnetic actuator calibration parameters. This action can correspond to step d) in FIG. 2. The position over time and hence the sample container carrier calibration movement profile of the sample container carrier 140″ can be detected by the control unit 150. This action can correspond to step e) in FIG. 2. The calibration of the sample container carrier 140″ can be optional as indicated by a dashed arrow in FIG. 2. The control unit 150 can compare sample container carrier calibration movement profile of the sample container carrier 140″ to the target sample container carrier calibration movement profile and can determine a sample container carrier calibration parameter for the sample container carrier 140″. This action can correspond to step f) in FIG. 2.


The determined sample container carrier calibration parameter for the sample container carrier 140″ can be wireless transferred from the control unit 150 to a receiving, sending and sample container carrier calibration parameter memory unit 250 of the sample container carrier 140″. Each of the sample container carriers 140, 140′, 140″ can be individually addressable. Before the sample container carrier 140″ is moved a next time, the sample container carrier calibration parameter can be read from the sample container carrier 140″ and the electro-magnetic actuators 120, 120′, 120″ can be operated accordingly. This action can correspond to step g) in FIG. 2.


For example, the magnetic field of the permanent magnet of the sample container carrier 140″ may be lower than a target magnetic field of the sample container carrier 140′, and hence the sample container carrier 140″ can be attracted by a magnetic force smaller than a target magnetic force. Hence, the sample container carrier 140″ can arrive later in time above the electro-magnetic actuator 120″ than scheduled for a strong enough magnetic field of the permanent magnet of the sample container carrier 140″. From the deviation in time, the sample container carrier calibration parameter can be deduced. In this case, the sample container carrier calibration parameter can comprise a second electric power supply parameter, which can have the value one for no time deviation, but can have a value larger than one because of the late arrival. When the electro-magnetic actuator 120″ is activated a next time to attract the sample container carrier 140″, the sample container carrier calibration parameter can be read and the electro-magnetic actuators 120″ can be supplied with electric energy with the magnitude of the last time multiplied by the second electric power supply parameter, i.e. the default driving voltage multiplied by the first electric power supply parameter and the second electric power supply parameter.


If the determined sample container carrier calibration parameter for the sample container carrier 140″ exceeds a specified sample container carrier parameter threshold value, e.g. two, the sample container carrier 140″ can be disqualified. This action can be optional as indicated by a dashed arrow in FIG. 2. For example, the control unit 150 can report an error message about the sample container carrier 140″ to a human operator of the laboratory automation system 10.


For the sample container carrier 140 on the right part of the transport plane 110, a sample container carrier calibration parameter has already been determined. The electro-magnetic actuators 120 arranged below the right part of the transport plane 110 can be operated in accordance with the sample container carrier calibration parameter of the sample container carrier 140 and their electro-magnetic actuator calibration parameters.


Hence, a respective electro-magnetic actuator 120, 120′, 120″ can be operated according to its first electric power supply parameter and the second electric power supply parameter of the corresponding sample container carrier 140, 140′, 140″, i.e. the electro-magnetic actuator 120, 120′, 120″ can be driven with the default driving voltage multiplied by the first electric power supply parameter and the second electric power supply parameter, when the electro-magnetic actuator 120, 120′, 120″ is activated.


Additionally or alternatively, it can be possible to compensate deviations regarding physical properties of the components of the laboratory sample distribution system 100 in other ways. For example, the electro-magnetic actuator calibration parameters of the electro-magnetic actuators 120, 120′, 120″ may comprise first activating time duration parameters and the sample container carrier calibration parameters of the sample container carriers 140, 140′, 140″ may comprise second activating time duration parameters. Hence a respective electro-magnetic actuator 120, 120′, 120″ can be operated according to its first activating time duration parameter and the second activating time duration parameter of the corresponding sample container carrier 140, 140′, 140″, i.e. the electro-magnetic actuator 120, 120′, 120″ can be driven with the default driving voltage for a default time duration multiplied by the first activating time duration parameter and the second activating time duration parameter.


It is noted that terms like “preferably,” “commonly,” and “typically” are not utilized herein to limit the scope of the claimed embodiments or to imply that certain features are critical, essential, or even important to the structure or function of the claimed embodiments. Rather, these terms are merely intended to highlight alternative or additional features that may or may not be utilized in a particular embodiment of the present disclosure.


Having described the present disclosure in detail and by reference to specific embodiments thereof, it will be apparent that modifications and variations are possible without departing from the scope of the disclosure defined in the appended claims. More specifically, although some aspects of the present disclosure are identified herein as preferred or particularly advantageous, it is contemplated that the present disclosure is not necessarily limited to these preferred aspects of the disclosure.

Claims
  • 1. A method of operating a laboratory sample distribution system, the laboratory sample distribution system comprising a number of sample container carriers, the sample container carriers each comprising at least one magnetically active device and adapted to carry at least one sample container, a transport plane adapted to support the sample container carriers, and a number of electro-magnetic actuators stationary arranged below the transport plane, the electro-magnetic actuators adapted to move a corresponding sample container carrier on top of the transport plane by applying a magnetic force to the sample container carrier, the method comprising: a) activating one of the number electro-magnetic actuators to apply a magnetic force to one of the number of sample container carriers in order to cause a movement of the one sample container carrier;b) detecting an electro-magnetic actuator calibration movement profile of the one sample container carrier;c) determining at least one electro-magnetic actuator calibration parameter for the one electro-magnetic actuator in response to the electro-magnetic actuator calibration movement profile; andd) operating the one electro-magnetic actuator according to the at least one determined electro-magnetic actuator calibration parameter, when the one electro-magnetic actuator is activated a next time.
  • 2. The method according to claim 1, wherein the steps a) to d) are executed for each of the number of electro-magnetic actuators.
  • 3. The method according to claim 1, wherein the at least one electro-magnetic actuator calibration parameter comprises a first electric power supply parameter of the one electro-magnetic actuator.
  • 4. The method according to claim 3, wherein in step d), the one electro-magnetic actuator is supplied with electric power according to the first electric power supply parameter.
  • 5. The method according to claim 1, wherein the at least one electro-magnetic actuator calibration parameter comprises a first activating time duration parameter of the one electro-magnetic actuator.
  • 6. The method according to claim 5, wherein in step d), the one electro-magnetic actuator is activated according to the first activating time duration parameter.
  • 7. The method according to claim 1, further comprising, disqualifying the one electro-magnetic actuator, if the at least one electro-magnetic actuator calibration parameter exceeds a specified electro-magnetic actuator parameter threshold value and/orif a change of the at least one electro-magnetic actuator calibration parameter between at least two consecutive executions of the steps a) to c) exceeds a specified electro-magnetic actuator parameter change limit.
  • 8. The method according to claim 1, wherein the steps performed during operating the one electro-magnetic actuator according to step d) are: e) detecting a sample container carrier calibration movement profile of one of the number of sample container carriers;f) determining at least one sample container carrier calibration parameter for the one sample container carrier in response to the sample container carrier calibration movement profile; andg) operating the one electro-magnetic actuator according to the at least one determined sample container carrier calibration parameter.
  • 9. The method according to claim 8, wherein each of the number of sample container carriers comprises a sample container carrier calibration parameter memory unit.
  • 10. The method according to claim 9, further comprising, storing the at least one sample container carrier calibration parameter on the sample container carrier calibration parameter memory unit; andreading the at least one sample container carrier calibration parameter from the sample container carrier calibration parameter memory unit before step g).
  • 11. The method according to claim 8, wherein the at least one sample container carrier calibration parameter comprises a second electric power supply parameter of the one electro-magnetic actuator.
  • 12. The method according to claim 11, wherein in step g), the electro-magnetic actuator is supplied with electric power according to the second electric power supply parameter.
  • 13. The method according to claim 8, wherein the at least one sample container carrier calibration parameter comprises a second activating time duration parameter of the one electro-magnetic actuator.
  • 14. The method according to claim 13, wherein in step g), the electro-magnetic actuator is supplied with electric power according to the second activating time duration parameter.
  • 15. The method according to claim 8, further comprising, disqualifying the one sample container carrier, if the at least one sample container carrier calibration parameter exceeds a specified sample container carrier parameter threshold value and/orif a change of the at least one sample container carrier calibration parameter between at least two consecutive executions of the steps e) to f) exceeds a specified sample container carrier parameter change limit.
  • 16. A laboratory sample distribution system adapted to perform the method according to claim 1, the laboratory sample distribution system comprising: a number of sample container carriers, the sample container carriers each comprising at least one magnetically active device and adapted to carry at least one sample container;a transport plane adapted to support said sample container carriers;a number of electro-magnetic actuators stationary arranged below the transport plane, the electro-magnetic actuators adapted to move a corresponding sample container carrier on top of the transport plane by applying a magnetic force to the sample container carrier; anda control unit adapted to activate one of the number of electro-magnetic actuators to apply a magnetic force to one of the number of sample container carriers to cause a movement of the one sample container carrier and to detect an electro-magnetic actuator calibration movement profile of the one sample container carrier and adapted to determine at least one electro-magnetic actuator calibration parameter for the one electro-magnetic actuator in response to the electro-magnetic actuator calibration movement profile and to operate the one electro-magnetic actuator according to the at least one determined electro-magnetic actuator calibration parameter, when the one electro-magnetic actuator is activated a next time.
  • 17. The laboratory sample distribution system according to claim 16, wherein each of the number of sample container carriers comprises a sample container carrier calibration parameter memory unit for the at least one sample container carrier calibration parameter.
  • 18. A laboratory automation system, the laboratory automation system comprising: a number of a pre-analytical, analytical and/or post-analytical laboratory stations; anda laboratory sample distribution system according to claim 16 adapted to distribute the sample container carriers and/or sample containers between the laboratory stations.
Priority Claims (1)
Number Date Country Kind
14184818 Sep 2014 EP regional
CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of PCT/EP2015/071041, filed Sep. 15, 2015, which is based on and claims priority to EP 14184818.4, filed Sep. 15, 2014, which is hereby incorporated by reference.

US Referenced Citations (177)
Number Name Date Kind
3273727 Rogers et al. Sep 1966 A
3653485 Donlon Apr 1972 A
3901656 Durkos et al. Aug 1975 A
4150666 Brush Apr 1979 A
4395164 Beltrop et al. Jul 1983 A
4544068 Cohen Oct 1985 A
4771237 Daley Sep 1988 A
5120506 Saito et al. Jun 1992 A
5295570 Grecksch et al. Mar 1994 A
5309049 Kawada et al. May 1994 A
5457368 Jacobsen et al. Oct 1995 A
5523131 Isaacs et al. Jun 1996 A
5530345 Murari et al. Jun 1996 A
5636548 Dunn et al. Jun 1997 A
5641054 Mori et al. Jun 1997 A
5651941 Stark et al. Jul 1997 A
5720377 Lapeus et al. Feb 1998 A
5735387 Polaniec et al. Apr 1998 A
5788929 Nesti Aug 1998 A
6045319 Uchida et al. Apr 2000 A
6062398 Thalmayr May 2000 A
6141602 Igarashi et al. Oct 2000 A
6151535 Ehlers Nov 2000 A
6184596 Ohzeki Feb 2001 B1
6191507 Peltier et al. Feb 2001 B1
6206176 Blonigan et al. Mar 2001 B1
6255614 Yamakawa et al. Jul 2001 B1
6260360 Wheeler Jul 2001 B1
6279728 Jung et al. Aug 2001 B1
6293750 Cohen et al. Sep 2001 B1
6429016 McNeil Aug 2002 B1
6444171 Sakazume et al. Sep 2002 B1
6571934 Thompson et al. Jun 2003 B1
7028831 Veiner Apr 2006 B2
7078082 Adams Jul 2006 B2
7122158 Itoh Oct 2006 B2
7278532 Martin Oct 2007 B2
7326565 Yokoi et al. Feb 2008 B2
7425305 Itoh Sep 2008 B2
7428957 Schaefer Sep 2008 B2
7578383 Itoh Aug 2009 B2
7597187 Bausenwein et al. Oct 2009 B2
7850914 Veiner et al. Dec 2010 B2
7858033 Itoh Dec 2010 B2
7875254 Garton et al. Jan 2011 B2
7939484 Loeffler et al. May 2011 B1
8240460 Bleau et al. Aug 2012 B1
8281888 Bergmann Oct 2012 B2
8502422 Lykkegaard Aug 2013 B2
8796186 Shirazi Aug 2014 B2
8833544 Stoeckle et al. Sep 2014 B2
8973736 Johns et al. Mar 2015 B2
9097691 Onizawa et al. Aug 2015 B2
9211543 Ohga et al. Dec 2015 B2
9423410 Buehr Aug 2016 B2
9423411 Riether Aug 2016 B2
9567167 Sinz Feb 2017 B2
9575086 Heise et al. Feb 2017 B2
9593970 Sinz Mar 2017 B2
9618525 Malinowski et al. Apr 2017 B2
9658241 Riether et al. May 2017 B2
20020009391 Marquiss et al. Jan 2002 A1
20020028158 Wardlaw Mar 2002 A1
20030092185 Qureshi et al. May 2003 A1
20040050836 Nesbitt et al. Mar 2004 A1
20040084531 Itoh May 2004 A1
20050061622 Martin Mar 2005 A1
20050109580 Thompson May 2005 A1
20050194333 Veiner et al. Sep 2005 A1
20050196320 Veiner et al. Sep 2005 A1
20050226770 Allen et al. Oct 2005 A1
20050242963 Oldham et al. Nov 2005 A1
20050247790 Itoh Nov 2005 A1
20050260101 Nauck et al. Nov 2005 A1
20050271555 Itoh Dec 2005 A1
20060000296 Salter Jan 2006 A1
20060047303 Ortiz et al. Mar 2006 A1
20060219524 Kelly et al. Oct 2006 A1
20070116611 DeMarco May 2007 A1
20070210090 Sixt et al. Sep 2007 A1
20070248496 Bondioli et al. Oct 2007 A1
20070276558 Kim Nov 2007 A1
20080012511 Ono Jan 2008 A1
20080029368 Komori Feb 2008 A1
20080056328 Rund et al. Mar 2008 A1
20080131961 Crees et al. Jun 2008 A1
20090004732 LaBarre et al. Jan 2009 A1
20090022625 Lee et al. Jan 2009 A1
20090081771 Breidford et al. Mar 2009 A1
20090128139 Drenth et al. May 2009 A1
20090142844 Le Comte Jun 2009 A1
20090180931 Silbert et al. Jul 2009 A1
20090322486 Gerstel Dec 2009 A1
20100000250 Sixt Jan 2010 A1
20100152895 Dai Jun 2010 A1
20100175943 Bergmann Jul 2010 A1
20100186618 King et al. Jul 2010 A1
20100255529 Cocola et al. Oct 2010 A1
20100300831 Pedrazzini Dec 2010 A1
20100312379 Pedrazzini Dec 2010 A1
20110050213 Furukawa Mar 2011 A1
20110124038 Bishop et al. May 2011 A1
20110172128 Davies et al. Jul 2011 A1
20110186406 Kraus et al. Aug 2011 A1
20110287447 Norderhaug et al. Nov 2011 A1
20120037696 Lavi Feb 2012 A1
20120129673 Fukugaki et al. May 2012 A1
20120178170 Van Praet Jul 2012 A1
20120211645 Tullo et al. Aug 2012 A1
20120275885 Furrer et al. Nov 2012 A1
20120282683 Mototsu Nov 2012 A1
20120295358 Ariff et al. Nov 2012 A1
20120310401 Shah Dec 2012 A1
20130034410 Heise et al. Feb 2013 A1
20130153677 Leen et al. Jun 2013 A1
20130180824 Kleinikkink et al. Jul 2013 A1
20130263622 Mullen et al. Oct 2013 A1
20130322992 Pedrazzini Dec 2013 A1
20140170023 Saito et al. Jun 2014 A1
20140234065 Heise et al. Aug 2014 A1
20140234949 Wasson et al. Aug 2014 A1
20140234978 Heise et al. Aug 2014 A1
20150014125 Hecht Jan 2015 A1
20150166265 Pollack et al. Jun 2015 A1
20150241457 Miller Aug 2015 A1
20150273468 Croquette et al. Oct 2015 A1
20150273691 Pollack Oct 2015 A1
20150276775 Mellars et al. Oct 2015 A1
20150276776 Riether Oct 2015 A1
20150276777 Riether et al. Oct 2015 A1
20150276778 Riether et al. Oct 2015 A1
20150276782 Riether Oct 2015 A1
20160003859 Wenczel et al. Jan 2016 A1
20160025756 Pollack et al. Jan 2016 A1
20160054341 Edelmann Feb 2016 A1
20160077120 Riether Mar 2016 A1
20160229565 Margner Aug 2016 A1
20160274137 Baer Sep 2016 A1
20160282378 Malinowski et al. Sep 2016 A1
20160341750 Sinz et al. Nov 2016 A1
20160341751 Huber et al. Nov 2016 A1
20170059599 Riether Mar 2017 A1
20170096307 Mahmudimanesh et al. Apr 2017 A1
20170097372 Heise et al. Apr 2017 A1
20170101277 Malinowski Apr 2017 A1
20170108522 Baer Apr 2017 A1
20170131307 Pedain May 2017 A1
20170131309 Pedain May 2017 A1
20170131310 Volz et al. May 2017 A1
20170138971 Heise et al. May 2017 A1
20170160299 Schneider et al. Jun 2017 A1
20170168079 Sinz Jun 2017 A1
20170174448 Sinz Jun 2017 A1
20170184622 Sinz et al. Jun 2017 A1
20170248623 Kaeppeli et al. Aug 2017 A1
20170248624 Kaeppeli et al. Aug 2017 A1
20170363608 Sinz Dec 2017 A1
20180067141 Mahmudimanesh et al. Mar 2018 A1
20180074087 Heise et al. Mar 2018 A1
20180106821 Vollenweider et al. Apr 2018 A1
20180128848 Schneider et al. May 2018 A1
20180156835 Hassan Jun 2018 A1
20180188280 Malinowski Jul 2018 A1
20180210000 van Mierlo Jul 2018 A1
20180210001 Reza Jul 2018 A1
20180217174 Malinowski Aug 2018 A1
20180217176 Sinz et al. Aug 2018 A1
20180224476 Birrer et al. Aug 2018 A1
20180348244 Ren Dec 2018 A1
20180348245 Schneider et al. Dec 2018 A1
20190018027 Hoehnel Jan 2019 A1
20190076845 Huber et al. Mar 2019 A1
20190076846 Durco et al. Mar 2019 A1
20190086433 Hermann et al. Mar 2019 A1
20190094251 Malinowski Mar 2019 A1
20190094252 Waser et al. Mar 2019 A1
20190101468 Haldar Apr 2019 A1
Foreign Referenced Citations (92)
Number Date Country
201045617 Apr 2008 CN
102109530 Jun 2011 CN
3909786 Sep 1990 DE
10200505012 Apr 2007 DE
102005051012 Apr 2007 DE
102012000665 Aug 2012 DE
102011090044 Jul 2013 DE
0601213 Oct 1992 EP
0775650 May 1997 EP
0916406 May 1999 EP
1122194 Aug 2001 EP
1524525 Apr 2005 EP
2119643 Nov 2009 EP
2148117 Jan 2010 EP
2327646 Jun 2011 EP
2447701 May 2012 EP
2500871 Sep 2012 EP
2589966 May 2013 EP
2589966 May 2013 EP
2502675 Feb 2014 EP
2887071 Jun 2015 EP
2165515 Apr 1986 GB
S56-147209 Nov 1981 JP
60-223481 Nov 1985 JP
61-081323 Apr 1986 JP
S61-069604 Apr 1986 JP
S61-094925 May 1986 JP
S61-174031 Aug 1986 JP
S61-217434 Sep 1986 JP
S62-100161 May 1987 JP
S63-31918 Feb 1988 JP
S63-48169 Feb 1988 JP
S63-82433 May 1988 JP
S63-290101 Nov 1988 JP
1148966 Jun 1989 JP
H01-266860 Oct 1989 JP
H02-87903 Mar 1990 JP
03-112393 May 1991 JP
03-192013 Aug 1991 JP
H03-38704 Aug 1991 JP
H04-127063 Apr 1992 JP
H05-69350 Mar 1993 JP
H05-142232 Jun 1993 JP
H05-180847 Jul 1993 JP
06-26808 Feb 1994 JP
H06-148198 May 1994 JP
06-156730 Jun 1994 JP
06-211306 Aug 1994 JP
07-228345 Aug 1995 JP
07-236838 Sep 1995 JP
H07-301637 Nov 1995 JP
H09-17848 Jan 1997 JP
H11-083865 Mar 1999 JP
H11-264828 Sep 1999 JP
H11-304812 Nov 1999 JP
H11-326336 Nov 1999 JP
2000-105243 Apr 2000 JP
2000-105246 Apr 2000 JP
2001-124786 May 2001 JP
2001-240245 Sep 2001 JP
2005-001055 Jan 2005 JP
2005-249740 Sep 2005 JP
2006-106008 Apr 2006 JP
2007-309675 Nov 2007 JP
2007-314262 Dec 2007 JP
2007-322289 Dec 2007 JP
2009-036643 Feb 2009 JP
2009-062188 Mar 2009 JP
2009-145188 Jul 2009 JP
2009-300402 Dec 2009 JP
2010-243310 Oct 2010 JP
2010-271204 Dec 2010 JP
2013-172009 Feb 2013 JP
2013-190400 Sep 2013 JP
685591 Sep 1979 SU
1996036437 Nov 1996 WO
2003042048 May 2003 WO
2007024540 Mar 2007 WO
2008133708 Nov 2008 WO
2009002358 Dec 2008 WO
2010042722 Apr 2010 WO
2012170636 Jul 2010 WO
2010087303 Aug 2010 WO
2010129715 Nov 2010 WO
2012158520 Nov 2012 WO
2012158541 Nov 2012 WO
2013152089 Oct 2013 WO
2013169778 Nov 2013 WO
2013177163 Nov 2013 WO
2014059134 Apr 2014 WO
2014071214 May 2014 WO
2015104263 Jul 2015 WO
Non-Patent Literature Citations (1)
Entry
International Search Report dated Jan. 12, 2016, in Application No. PCT/EP2015/071041, 4 pages.
Related Publications (1)
Number Date Country
20170184622 A1 Jun 2017 US
Continuations (1)
Number Date Country
Parent PCT/EP2015/071041 Sep 2015 US
Child 15455773 US