Claims
- 1. A method of producing stable trifluoromethyl copper reagent of the formula CF.sub.3 Cu from a difluoromethyl halide of the formula CF.sub.2 XY, comprising: reacting a compound of the formula CF.sub.2 XY, wherein X and Y are halogens, with a metal selected from the group of cadmium and zinc to provide a trifluoromethyl metal halide of the formula CF.sub.3 MX wherein M is a metal selected from the group of cadmium and zinc; and thereafter
- reacting said trifluoromethyl compound of the formula CF.sub.3 MX with a copper salt of the formula CuZ, wherein Z is any reaction solvent soluble anion to provide said stable trifluoromethyl copper reagent.
- 2. The method of claim 1 wherein said reaction is conducted in the presence of an aprotic solvent.
- 3. The method of claim 2 wherein said solvent is selected from the group consisting of methylformamide, dimethylformamide, acetonitrile, N-methylpyrrolidine and dimethylsulfide.
- 4. The method of claim 3 wherein said solvent is dimethylflormamide.
- 5. The method of claim 1 wherein X is chloride.
- 6. The method of claim 1 wherein X is bromide.
- 7. The method of claim 1 wherein X is iodine.
- 8. The method of claim 1 wherein Z is a halide.
- 9. The method of claim 1 wherein said reaction is conducted at less than 0.degree. C.
- 10. The method of claim 1 wherein said reaction is conducted at a temperature of from about -70.degree. C. to about 0.degree. C.
- 11. The method of claim 9 wherein said reaction is conducted at a temperature of from about -40.degree. C. to about -70.degree. C.
Parent Case Info
This is a division of application Ser. No. 651,163, filed Sept. 17, 1984.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
3401186 |
Muller et al. |
Sep 1968 |
|
3549678 |
Muller et al. |
Dec 1970 |
|
3700710 |
Mottus et al. |
Oct 1972 |
|
3809726 |
Horowitz et al. |
May 1974 |
|
Non-Patent Literature Citations (1)
Entry |
Chemical Abstracts 94 174487v (1981). |
Divisions (1)
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Number |
Date |
Country |
Parent |
651163 |
Sep 1984 |
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