Claims
- 1. A method for inhibition of an ocular disease resulting from proliferation of retinal pigment epithelium (PRE) comprising contacting the retinal pigment epithelial cells of a patient in need thereof with a therapeutic amount of at least one AP-1 antagonist and at least one retinoic acid receptor (RAR) agonist, except for retinoic acid.
- 2. A method of inhibition of a hyperproliferative ocular disease comprising contacting the retinal pigment epithelial cells of a patient in need thereof with a therapeutic amount of at least one AP-1 antagonist and at least one retinoic acid receptor agonist, except for retinoic acid.
- 3. A method for inhibition of an ocular disease resulting from choroidal neovascularization (CNV) comprising contacting the retinal pigment epithelial cells of a patient in need thereof with a therapeutic amount of at least one AP-1 antagonist.
- 4. The method of claim 3 wherein the AP-1 antagonist is administered in combination with at least one retinoic acid receptor agonist, except for retinoic acid.
- 5. A method for screening anti-proliferative RAR agonists comprising determination of their ability to inhibit AP-1-dependent gene expression.
- 6. The method of claim 5 wherein the AP-1-dependent gene expression inhibition ability is determined in a transient transfection CAT assay.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation of U.S. Ser. No. 08/875,665, filed Jan. 23, 1998 (U.S. Pat. No. 6,075,032, issued Jun. 13, 2000); which is a PCT National Phase application of PCT/US96/01505, filed Jan. 31, 1996, and a continuation-in-part of U.S. Ser. No. 08/383,741, filed Feb. 1, 1995 (U.S. Pat. No. 5,824,685, issued Oct. 20, 1998).
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5234926 |
Chandraratna |
Aug 1993 |
A |
Non-Patent Literature Citations (1)
Entry |
Fekrat, S., et al. “The effect of oral 13-cis-retinoic acid on retinal redetachment after surgical repair in eyes with proliferative vitreoretinopathy.” Opthalmology, Mar. 1995, pp. 412-418, XP000942676. |
Continuations (1)
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08/875665 |
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09/536221 |
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Continuation in Parts (1)
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08/383741 |
Feb 1995 |
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08/875665 |
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