Claims
- 1. A method of producing liposomal products which comprises contacting a positively or negatively charged, freeze- or spray--dried preparation of liposomes with an aqueous solution of a drug charged oppositely to the charge of the liposomes, wherein the total concentration of ions, excluding the charged drug, in the aqueous solution of a charged drug is not more than 40mM, and wherein the ratio of the amount of charged lipid in the preparation of liposomes to the total amount of liposomal membrane components is 10 to 30 mole percent.
- 2. A method of producing liposomal products as claimed in claim 1, wherein charged lipid in the preparation of liposomes is present in an amount of not less than 2, on an ionic equivalent basis relative to the drug.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2-219735 |
Aug 1990 |
JPX |
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Parent Case Info
This is a continuation of application Ser. No. 07/729,268 filed Jul. 12, 1991, now abandoned.
US Referenced Citations (4)
Continuations (1)
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Number |
Date |
Country |
Parent |
729268 |
Jul 1991 |
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