Claims
- 1. A method for producing (R)-2-amino-1-phenylethanol or a halogen substituted derivative thereof comprising the steps of: reacting a mixture of the enantiomers of threo-3-phenylserine of Formula (1), wherein X is H, F, Cl, Br or I and may be located at the ortho, meta or para position of the benzene ring, with tyrosine decarboxylase to produce a compound of formula (2), wherein X is as defined above; and
- collecting the resulting compound of formula (2) ##STR4##
- 2. The method of claim 1 wherein the compound of formula (1) is threo-3-(3-chlorophenyl)serine.
- 3. The method of claim 1 or 2, wherein the tyrosine decarboxylase is derived from microorganisms of the genus Enterococcus.
- 4. The method of claim 3, wherein the tyrosine decarboxylase is derived from Enterococcus faecalis.
- 5. The method of claim 3, wherein the tyrosine decarboxylase is derived from Enterococcus hirae.
- 6. A method for enriching a mixture of enantiomers of formula (1) in an optically active phenylserine or a halogen substituted derivative thereof comprising the steps of:
- reacting a mixture of the enantiomers of threo-3-phenylserine of Formula (1), wherein X is H, F, Cl, Br or I and may be located at the ortho, meta or para position of the benzene ring, with tyrosine decarboxylase to produce a composition enriched in an optically active phenylserine or a halogenated derivative thereof; and
- collecting the enriched optically active phenylserine composition.
- 7. The method of claim 6 wherein the compound of formula (1) is threo-3-(3-chlorophenyl)serine. ##STR5##
- 8. The method of claim 6 or 7, wherein the tyrosine decarboxylase is derived from microorganisms of the genus Enterococcus.
- 9. The method of claim 8, wherein the tyrosine decarboxylase is derived from Enterococcus faecalis.
- 10. The method of claim 8, wherein the tyrosine decarboxylase is derived from Enterococcus hirae.
Priority Claims (4)
Number |
Date |
Country |
Kind |
6-33912 |
Mar 1994 |
JPX |
|
6-33916 |
Mar 1994 |
JPX |
|
6-250759 |
Oct 1994 |
JPX |
|
PCT/JP95/00337 |
Mar 1995 |
WOX |
|
Parent Case Info
This is a Division of application Ser. No. 08/696,844 filed on Aug. 29, 1996, now U.S. Pat. No. 5,731,175, which was filed as International Application No. PCT/JP95/00337 on Mar. 2, 1995.
Foreign Referenced Citations (2)
Number |
Date |
Country |
54-12554 |
May 1979 |
JPX |
63-214188 |
Sep 1988 |
JPX |
Non-Patent Literature Citations (1)
Entry |
Richard J. Ulevitch et al., "Susdies of the Reactions of Sustituted D,L-Erthro-.beta.-Phenylserines with Lamb Liver Serine Hydroxymethylase. Effects of Substituents Upon the Dealdolization step". Biochemistry, vol. 16, No. 24, pp. 5355-5363, (1977). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
696844 |
Feb 1996 |
|