Claims
- 1. A method of producing a povidone iodine preparation having a predetermined concentration of free iodine which is immediately achieved and which remains constant and having predictable microbicidal effectiveness and long duration of action, the method comprising the steps of treating a mixture of povidone iodine and iodine ion in acidic solution with iodate ion to form an acidic solution containing between 2 and 20 ppm of free iodine and having an a available iodine to iodide ratio between 2:1 and 10:1, increasing the pH of said acidic solution to between 5 and 6, and adding additional iodate ion to the thus formed solution in an amount sufficient to maintain the amount of free iodine therein at a concentration of between 2 and 20 ppm, whereby the free iodine concentration is immediately achieved and remains stable for at least 12 months at 20.degree. C.
- 2. A method according to claim 1 wherein the total amount of iodate ion added is between 0.22 wt % and 15 wt % of the preparation.
- 3. The method of claim 1 wherein the iodide ions are supplied by potassium iodide and the iodate ions are supplied by potassium iodate.
- 4. The method of claim 1 wherein the available iodine to iodide ratio is between 2:1 and 6:1.
- 5. The method of claim 1 wherein the available iodine to iodide ratio is between 2.1:1 and 3.6:1.
- 6. The method of claim 1 wherein the amount of iodate ion added is sufficient to maintain the concentration of free iodine at between 2-10 ppm.
- 7. The method of claim 1 wherein the amount of iodate ion is sufficient to maintain the free iodine concentration at between 2.5-3 ppm.
- 8. The method of claim 1 wherein the amount of iodate ion added is sufficient to maintain the concentration of free iodine at between 5-6 ppm.
- 9. The method of claim 1 wherein the pH of said acidic solution is increased to between 5.5-5.9.
Priority Claims (2)
Number |
Date |
Country |
Kind |
3307219 |
Mar 1983 |
DEX |
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3313655 |
Apr 1983 |
DEX |
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CROSS REFERENCE TO RELATED APPLICATIONS
This is a continuation of application Ser. No. 927,841, filed 11-5-86, now abandoned, which is a continuation-in-part of U.S. Pat. application Ser. No. 802,322, filed Nov. 27, 1985, now abandoned, which is itself a continuation of U.S. Pat. application Ser. No. 585,428, filed Mar. 2, 1984, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4271149 |
Winicov et al. |
Jun 1981 |
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Continuations (2)
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Number |
Date |
Country |
Parent |
927841 |
Nov 1986 |
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Parent |
585428 |
Mar 1984 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
802322 |
Nov 1985 |
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