Claims
- 1. A sustained release form of (Pyr)-Glu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NH-C.sub.2 H.sub.5 in the form of a plurality of microcapsules of (Pyr)-Glu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NH-C.sub.2 H.sub.5 free from aggregation, said microcapsules containing (Pyr)-Glu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NH-C.sub.2 H.sub.5 from a W/O emulslon comprising an inner aqueous phase containing said (Pyr)-Glu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NH-C.sub.2 H.sub.5 and an external oil phase containing an aliphatic biodegradable polymer based upon an aliphatic ester has an average molecular weight of about 3,000 to 30,000 and a dispersity of about 1.2 to 4.0 and the content of the biodegradable polymer is 90.9% (w/w) to the microcapsules, wherein said microcapsules formed on microencapsulation of said (Pyr)-Glu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NH-C.sub.2 H.sub.5 with said biodegradable polymer are then heated at a temperature at or above the glass transition temperature of said aliphatic biodegradable polymer, said heating being conducted at a temperature that does not cause aggregation of the microcapsules.
Priority Claims (1)
Number |
Date |
Country |
Kind |
4-234821 |
Sep 1992 |
JPX |
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Parent Case Info
This application is a continuation of application Ser. No. 08/115,149, filed Sep. 2, 1993, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3956172 |
Saeki et al. |
May 1976 |
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Non-Patent Literature Citations (1)
Entry |
S. Keipert et al., "Antiglaumakotosahaltige Ophthalmika mit Prolongierter Wirkung auf Basis Makromolekularer Hilfsstoffe, Teil 3,"Die Pharmazie, vol. 45, No. 8, pp. 594-595 (Jul. 1990). |
Continuations (1)
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Number |
Date |
Country |
Parent |
115149 |
Sep 1993 |
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