Bettie, C.G. et al., J. Clin. Endocrin. Metalbol., 74:108-117 (1992). |
Lewy, A.J., et al., "Light Suppresses Melatonin Secretion in Humans", Science, 210:1267-1269 (1980). |
Aldhous, M. et al., "Plasma Concentrations of Melatonin in Man Following Oral Absorption of Different Preparations," Br. J. Cln. Pharma., 19:517-521 (1985). |
Waldhauser, F. et al., "Changes in Melatonin Secretion with Age and Pubescence," Proceedings of the First International Congress on Melatonin, pp. 179-191, Vienna, Austria (1985). |
Sack, R.L. et al., "Melatonin Administration to Blind People: Phase Advances and Entrainment," J. of Biol. Rhythms, 6(3):249-261 (1991). |
Palm, L. et al., "Correction of Non-24-Hour Sleep/Wake Cycle by Melatonin in a Blind Retarded Boy," Annals of Neurol., 29:336-339 (1991). |
Arendt, J. et al., "Some Effects of Jet-Lag and Their Alleviation by Melatonin," Ergonomics, 30:1379-1393, 1987. |
Skene, D. J. et al., "Melatonin, Jet-Lag and the Sleep-Wake Cycle," Sleep '88, ed. J. Horne, pp. 39-41, Gustav Fischer Verlag, New York (1989). |
Morton, D.J. et al., "Effect of Oral Melatonin at Various Dose Levels on Blood Pressure of Normotensive Humans," Med. Sci. Res., 17:837 (1989). |
Carman, J.S.. et al., "Negative Effects on Melatonin on Depression," Am. J. Psychiatry, 133:1181-1186 (1976). |
Waldhauser, F. et al., Lancet, 340:933-936 (1992). |
Cagnacci, A. et al., "Melatonin: a Major Regulator of the Circadian Rhythm of Core Temperature in Humans," J. Clin. Endocrin. Met., 75:447-452 (1992). |
Wendel, O.T. et al., Experimentia, 15:1167-1168 (1990). |
Waldheiser, F. et al., Neuroendocrinology, 46:125-130 (1987). |
Lieberman, H.R. et al, "Mood, Performance, and Pain Sensitivity, Changes Induced by Food Constituents," J. Psychiat. Res., 17(2):135-145 (1982/83). |
Nickelsen, T. et al., "Influence of Subchronic Intake of Melatonin at Various Times of the Day on Fatigue and Hormonal Levels: A Placebo-Controlled, Double-Blind Trail," J. Pineal Research, 6:325-334 (1989). |
MacFarlane, J.G. et al., "The Effects of Exogenous Melatonin on the Total Sleep Time and Daytime Alertness of Chronic Insomniacs: A Preliminary Study," Biol. Pyschiatry, 30:371-376 (1991). |
Arendt, J. et al., "The Effects of Chronic, Small Doses of Melatonin Given in the Late Afternoon on Fatigue in Man: A Preliminary Study," Neuroscience Letters, 45:317-321 (1984). |
James, S.P. et al., "The Effect of Melatonin on Normal Sleep," Neurophychopharmacology, 1(1):41-44 (1987). |
Vollrath, L. et al., "Sleep Induction by Intranasal Application of Melatonin," Adv. in Bioscience, 29:327-329 (1981). |
Hamilton, M., "Hamilton Psychiatric Rating Scale for Depression," Br. J. Soc. Clin. Psychol., 6:278-296 (1967). |
Rosenthal, N.E., et al. The Psychobiology of Bulimia, eds. Hudson, II and Pope, J.G. Jr., American Psychiatric Press, Wash. D.C., pp. 205-228 (1987). |
Jones, D.M. et al., J. Appl. Psych., 64:627-634 (1979). |
Smith, A.P. et al., Neuropsychobiology, 18:144-148 (1987). |
Wilkinson, R.T., Progress in Clinical Psychology, eds. Reiss, B.F. and Abt, L.A., Grune & Stratton, NY, pp. 28-43 (1969). |
Lieberman, H.R. et al., Am. J. Clin. Nutr., 44:772-778 (1985). |
Wilkinson, A.T. et al., Behav. Res. Meth. Instrum., 7:441-446 (1975). |
File, S.E. et al., J. Clin. Psychopharmacol., 2:102-106 (1982). |
McNair, P.M. et al., Profile of Mood States Manual, Educational and Industrial Testing Service, San Diego, CA (1971). |
Hoddes, E. et al., "Quantification of Sleepiness: A New Approach," Psycho. Meth., 10:431-436 (1973). |
Lerner, A.B. et al., Frontier of Pineal Physiology, MIT Press (1975) pp. 42-43. |
Dawson, D. et al., "Melatonin and Sleep in Humans," J. Pineal Res., 15:1-12 (1993). |
Lewy, A.J., et al., "The Use of Plasma Melatonin Levels and Light in the Assessment and Treatment of Chronobiologic Sleep and Mood Disorders," J. Neural. Transm., 21:311-322 (1986). |
Borbely, A.A., "Endogenous Sleep-Substances and Sleep Regulation," J. Neural. Transm., 21:243-254 (1986). |
Touitou, Y. et al., "Melatonin and the Pineal Gland," Proceedings of the International Symposium on Melatonin and the Pineal Gland: From Basic Science to Clinical Application, pp. 235-239 (Sep. 6-9, 1992). |
Lisoni, P. et al., "Effect of an Acute Injection of Melatonin on the Basal Secretion Hypophyseal Hormones in Prepubertal and Pubertal Healthy Subjects," Acta Endocrinologica, 111:305-311 (1986). |
Cassone, V.M. et al., "Dose Dependent Entrainment of Rat Circadian Rhythms by Daily Injection of Melatonin," J. of Biol. Rhythms, 1(3):219-229 (1986). |
James, S.P. et al., "Melatonin Administration in Insomnia," Neuropsych., 3(1):19-23 (1990). |
Hoechst, A.G., "Melatonin Based Nasal Spray Compsn. for Use of Sleep Inducer--Prep by Dissolving Melatonin, i.e. 5-methoxy-N-acetyl Tryptamine in Aq Doln. Contg. Sodium Chloride," Derwent Publications, Ltd., London, GB, Week 8040, 29 Apr. 1980 (Abstract No. JP55057563). |
Johnson, L.C. and Chernik, D.A., "Sedative-Hypnotics and Human Performance," Psychopharm., 76:101-113 (1982). |
Johanson, C.E., and Uhlenhuth, E.H., "Drug Preference and Mood in Humans: Diazepam," Psychopharm. 71:269-273 (1980). |
Lewy, A.J., et al., "Immediate and Delayed Effects of Bright Light on Human Melatonin Production: Shifting Dawn and Dusk Shifts the Dim Light Melatonin Onset (DLMO).sup.a," In Wurtman, R.J., et al., The Medical and Biological Effects of Light, Annals of the New York Acad. of Sci., vol. 453 (1985). |
Arendt, J. et al., "Some Effects of Melatonin and the Control of its Secretion in Humans," Photoperiodism, Melatonin and the Pineal, CIBA Foundation Symposium, 117:266-283 (1985). |
Folkard, S. et al., "Melatonin stabilizes sleep onset time in a blind man without entrainment of cortisol or temperature rhythms," Neuroscience Letters, 113:193-198 (1990). |
Dahlitz, M. et al., "Delayed Sleep Phase Syndrome Response to Melatonin," The Lancet, 337:1121-1124 (1991). |
Ouichou, A. et al., "Delta-Sleep Inducing Peptide Stimulates Melatonin, 5-Methoxtryptophol and Serotonin Secretion from Perifused Rat Pineal Glands," Biol. Signals, 1:65-77 (1992). |
Lieberman, H.R. and Lea, A.E., "Melatonin: Effects on Sleep and Behavior in Man," Melatonin Clinical Perspectives, Oxford University Press, pp. 119-127 (1988). |
Waldhauser, F. et al., "Sleep Laboratory Investigations on Hypnotic Properties of Melatonin," Psychopharmacology, 100:222-226 (1990). |
Wurtman, R.J. and Waldhauser, F. et al., "Melatonin in Humans," Proc. of the First International Congress on Melatonin, Nov. 7-9, pp. 179-191, Vienna, Austria (1985). |
Lewy, A.J., et al., "A Complete PRC for Melatonin Administration in Humans," Abst. vol. 3, Society for Light Treatment and Biological Rhythms, p. 26 (1991). |
Dollins, A.B. et al., "Effects on Ambient Illumination on Human Nocturnal Serum Melatonin Levels and on Sustained Performance," Abst., vol. 3 Society for Light Treatment and Biological Rhythms, p. 25 (1991). |
Lieberman, H.R. et al., "Effects of Melatonin on Human Mood and Performance," Brain Research, 323:201-207 (1984). |
Reiter, R.J., "Melatonin: the Chemical Expression of Darkness," Mol. and Cell. Endoc., 79:C153-C158 (1991). |
Voordouw, B.C.G., et al., "Melatonin and Melatonin-Progestin Combinations Alter Pituitary-Ovarian Function in Women and Can Inhibit Ovulation," J. of Clinical Endoc. and Metab., 74(1):108-117 (1992). |
Anton-Tay, F., "Melatonin: Effects on Brain Function," Adv. Biochem Psychopharm., 11:315-324 (1974). |
Anton-Tay, F. et al., "On the Effect of Melatonin Upon Human Brain: Its Possible Therapeutic Implications," Life Sciences, 10:841-850, Part I (1971). |
Strassman, R.J. et al., "Elevated Rectal Temperature produced by All-Night Bright Light is Reversed by Melatonin Infusion in Men," J. Appl. Physiol., 71(6):2178-2182 (1991). |
Paccotti, P. et al., "Effects of Exogenous Melatonin on Human Pituitary and Adrenal . . . Opposite Circadian Stages in Men," Chronobiologia, 15:279-288 (1988). |
Cagnacci, A. et al., "Amplification of Pulsatile LH Secretion by Exogenous Melatonin in Women," J. of Clin. Endocrin. Metab., 73(1):210-212 (1991). |
Brezezinkski, A. et al., "The Circadian Rhythm of Plasma Melatonin During the Normal Menstrual Cycle and in Amenorrheic Women," J. of Clin. Endocrin. Metab., 66:891-895 (1988). |
Souetre. et a;/. "5-Methoxypsoralen Increases Evening Sleepiness in Humans: Possible Involvement of the Melatonin Secretion," Eur. J. Clin. Pharm., 36:91-92 (1989). |
Lewy, A.J. and Sack, R.L., "Use of Melatonin to Assess and Treat Circadian Phase Disorders," 1993 Elsevier Science Publishers, B.V., 205-210. |
Lewy, A.J. et al., "Melatonin Shifts Human Circadian Rhythms According to a Phase-Response Curve," Chronobiol. Int., 9:380-391 (1992). |
Dollins, A.B. et al., "Effect of Pharmacological Daytime Doses of Melatonin on Human Mood and Performance," Psychopharmacology, Ms. No. 146, 1-7 (1993). |
Dollins, A.B. et al., "Effects of Illunination on Human Nocturnal Serum Melatonin Levels and Performance," Physiology and Behavior, 53:153-160 (1993). |
Lewy, A.J. et al., "Melatonin and the Acute Suppressant Effect of Light May Help Regulate Circadian Rhythms in Humans," Advances Pineal Res., 5:285-293 (1991). |
Tzischinsky, O. et al., "The Importance of Timing in Melatonin Administration in a Blind Many," J. Pineal Res., 12:105 (1992). |
Dollins, A.B. et al., "Effect on Inducing Nocturnal Serum Melatonin Concentrations in Daytime Sleep, Mood, Body Temperature, and Performance," Proc. Natl. Acad. Sci. USA, 91:1824-1828 (1993). |
Tzischinsky, O. et al., "Time-Dependent Effects of 5 mg Melatonin on the Sleep . . . Function," J. Sleep Res., 1 Abst. 468 (1992). |