Claims
- 1. A method for the preparation of aloesin, alkylated at the C-7 hydroxyl group comprising reacting aloesin with a substituted or unsubsituted alkyl group containing a leaving group in the presence of a base.
- 2. The method of claim 1 wherein the leaving group is a halogen selected from the group consisting of Br, Cl or I.
- 3. The method of claim 1 wherein the leaving group is I and the base is Na.sub.2 CO.sub.3.
- 4. The method of claim 1 wherein the alkyl group is selected from the group consisting of C1-C8 carbon atoms.
- 5. A composition of matter produced by the method of claim 1.
- 6. A compound of the formula: ##STR9## wherein R is selected from the group consisting of a substituted or unsubstituted C2-C8 alkane, branched or straight chain.
- 7. The compound of claim 6 wherein R is selected from the group consisting of --CH.sub.2 CH.sub.3, --(CH.sub.2).sub.2 CH.sub.3, isopropyl, --(CH.sub.2).sub.3 CH.sub.3, sec-butyl, --(CH.sub.2).sub.4 CH.sub.3, --(CH.sub.2).sub.5 CH.sub.3, --(CH.sub.2).sub.6 CH.sub.3 and --(CH.sub.2).sub.7 CH.sub.3.
- 8. A method for the reversible de-pigmentation of the skin comprising, topically applying an effective amount of a composition comprising a compound produced by the method of claim 1.
- 9. A method for the reversible de-pigmentation of the skin comprising, topically applying an effective amount of a composition comprising a compound of claim 6.
RELATED APPLICATIONS
This application claims priority from United States Provisional Patent Application Serial No. 60/071,204, filed Jan. 12, 1998, entitled "Octylaloesin, A Skin Whitening Agent and Its Synthesis."
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