Claims
- 1. A method of treating a patient having precancerous lesions sensitive to compounds below and in the need of treatment, comprising administering to the patient a pharmacologically effective amount of a compound of the formula:
- 2. The method of claim 1, wherein R1, R2, R3, and R4, each of which may be the same or different from one another, are selected from a hydrogen atom, a cyano group, a halogen atom, or a lower alkoxy group.
- 3. The method of claim 2, wherein one of R1, R2, R3 and R4 is a cyano group, a halogen atom or a methoxy group.
- 4. The method of claim 3, wherein R2 is a halogen atom.
- 5. The method of claim 4, wherein R2 is a chlorine atom.
- 6. The method of claim 5, wherein R1, R3 and R4 are hydrogen atoms.
- 7. The method of claim 6, wherein Y is a group represented by the formula —(CH2)q—, wherein q is an integer of 1 to 8.
- 8. The method of claim 7, wherein R8 is benzyl group which may be substituted, said substitutions, each of which may be the same or different, are each selected from a hydrogen atom, a halogen atom, a hydroxy group, an amino group, a nitro group, a lower alkyl group, a lower alkoxy group, a lower alkoxyalkyl group, a lower alkenyl group, an acyl group, an acylamino group, an alkylsulfonylamino group, a hydroxyiminoalkyl group, an alkyloxycarbonylamino group, an alkyloxycarbonyloxy group or a heteroaryl group which may be substituted, or two of the substitutions may together form a saturated or unsaturated ring which may contain a nitrogen atom, a sulfer atom or an oxygen atom; and q is an integer of 1 to 8.
- 9. The method of claim 8, wherein R8 is a group represented by the formula:
- 10. The method of claim 9, wherein R7 is a hydrogen atom.
- 11. The method of claim 10, wherein R5 and R6 form a ring represented by the formula:
- 12. The method of claim 10, wherein said compound is 2-(4-Carboxyiperidino)-4-(3,4-methylenedioxybenzyl) amino-6-choroquinazolin.
- 13. The method of claim 1, wherein Y is a group represented by the formula —(CH2)q—, wherein q is an integer of 1 to 8.
- 14. The method of claim 13, wherein R8 is a group represented by the formula:
- 15. The method of claim 14, wherein one of R1, R2, R3 and R4 is a cyano group, a chlorine atom or a methoxy atom.
- 16. The method of claim 15, wherein R2 is a halogen atom.
- 17. The method of claim 16, wherein R2 is a chlorine atom.
- 18. The method of claim 17, wherein R1, R3 and R4 are hydrogen atoms.
- 19. The method of claim 18, wherein R5 and R6 form a ring which is represented by the formula:
- 20. The method for inhibiting the growth of neoplastic cells sensitive to a compound below, comprising exposing said cells to an effective amount of a compound of the formula:
- 21. The method of claim 20 wherein R1, R2, R3 and R4 may independently be a cyano group, a halogen or a methoxy group.
- 22. The method of claim 21, wherein R2 is a halogen.
- 23. The method of claim 22, wherein R8 is represented by the formula:
- 24. The method of claim 23, wherein R5 and R6 form a ring which is represented by the formula:
- 25. The method of claim 24, wherein said compound is 2-(4-Carboxyiperidino)-4-(3,4-methylenedioxybenzyl) amino-6-chloroquinazolin.
- 26. The method of claim 21 wherein R7 and R8 are each hydrogen; q is zero; and R5 and R6 form a substituted ring represented by the structure:
- 27. The method of regulating apoptosis in human cells, comprising exposing said cells to an effective amount of a compound of formula:
- 28. The method of claim 26, wherein R2 is a halogen.
- 29. The method of claim 27, wherein R8 is represented by the formula:
- 30. The method of claim 28, wherein R5 and R6 form a ring which is represented by the formula:
- 31. The method of claim 29, wherein said compound is 2-(4-Carboxypiperidino) -4- (3,4-methylenedioxybenzyl) amino-6-chloroquinazolin.
Parent Case Info
[0001] This application is a Continuation of prior U.S. application Ser. No. 09/055,829 filed Apr. 6, 1998, entitled “Method of Treating a Patient Having Precancerous Lesions with Quinazoline Derivatives,” which is a continuation of prior U.S. application Ser. No. 08/477,227 filed Jun. 7, 1995, entitled “Method of Treating a Patient Having Precancerous Lesions with Quinazoline Derivatives.”
Continuations (2)
|
Number |
Date |
Country |
Parent |
09055829 |
Apr 1998 |
US |
Child |
09850685 |
May 2001 |
US |
Parent |
08477227 |
Jun 1995 |
US |
Child |
09055829 |
Apr 1998 |
US |