Claims
- 1. A method for the therapy of leukocyte mediated diseases comprising extracorporeal administration to the blood of a subject undergoing ultraviolet-A photophoresis prior to reinfusion of the blood into said subject a composition comprising a sterile aqueous solution of about 0.005 mg/ml to about 1 mg/ml of a psoralen, ethyl alcohol, propylene glycol and water, said composition having a pH from about 2.0 to about 5.5.
- 2. The method of claim 1 wherein the leukocyte mediated condition is selected from the group consisting of Scleroderma, Systemic Lupus Erythematosis (SLE) Psoriasis, Pemphigus, Psoriatic Arthritis, Atopic Dermatitis, Rheumatoid Arthritis, Multiple Sclerosis.
- 3. The method of claim 1 wherein the psoralen is 8-MOP.
- 4. The method of claim 3 wherein the 8-MOP is administered to the patient's blood just after it is withdrawn from the patient and prior to its separation into leukocyte rich and leukocyte poor fractions.
Parent Case Info
This is a division of application Ser. No. 07/336,179, filed Apr. 11, 1989 now U.S. Pat. No. 4,999,375 issued Mar. 12, 1991.
US Referenced Citations (10)
Foreign Referenced Citations (1)
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Date |
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2052980 |
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GBX |
Non-Patent Literature Citations (6)
Entry |
Chemical Abstracts 97:11747c. |
Edelson, Scientific American, Aug. 1988, pp. 68. |
Dover et al., Archives of Dermatology, vol. 122:763 (1986). |
Sullivan et al., Archives of Dermatology, vol. 112:768 (1986). |
Monbaliu, et al., Dermatologica 163:468 (1981). |
Edelson, et al., New England Journal of Medicine, 316:297 (1987). |
Divisions (1)
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Number |
Date |
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Parent |
336179 |
Apr 1989 |
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