Claims
- 1. A method of treating a patient suffering from a neoplastic disease state comprising administering to said patient an effective antineoplastic amount of N,N'-bis[3-(ethylamino) propyl]-1,7-hepanediamine and an antineoplastic platinum coordination complex selected from the group consisting of cisplatin and carboplatin wherein a synergistic antineoplastic effect results.
- 2. The method according to claim 1, wherein the antineoplastic disease state is carcinoma, testicular teratoma or ovarian carcinoma.
- 3. The method according to claim 1, wherein the antineoplastic disease state is a leukemia.
- 4. The method according to claim 1, wherein the antineoplastic disease state is a carcinoma.
- 5. The method according to claim 1, wherein the synergistic effect results in an FIC value of less than 1.
- 6. The method according to claim 5, wherein the synergistic effect results in an FIC value of less than 0.9.
- 7. The method according to claim 6, wherein the synergistic effect results in an FIC value of less than 0.75.
- 8. The method according to claim 7, wherein the synergistic effect results in an FIC value of less than 0.5.
- 9. The method according to claim 1, wherein administration is sequential.
- 10. The method according to claim 1, wherein administration is alternative.
- 11. The method according to claim 1, wherein the antineoplastic platinum coordination complex is cisplatin.
- 12. The method according to claim 11, wherein the antineoplastic disease state is carcinoma, testicular teratoma or ovarian carcinoma.
CROSS-REFERENCE TO RELATED APPLICATION
This is a division of application Ser. No. 08/437,469, filed May 9, 1995, now U.S. Pat. No. 5,561,836, which is a continuation of application Ser. No. 08/187,437, filed Jan. 26, 1994, now abandoned, which is a continuation-in-part of application Ser. No. 08/062,693, filed May 17, 1993, now abandoned, which is a continuation of application Ser. No. 07/985,515, filed Dec. 2, 1992, now abandoned, which is a continuation of application Ser. No. 07/863,526, filed Apr. 3, 1992, now abandoned, which is a continuation of application Ser. No. 07/626,814, filed Dec. 13, 1990, now abandoned, which is herein incorporated by reference.
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Divisions (1)
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437469 |
May 1995 |
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Continuations (4)
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187437 |
Jan 1994 |
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985515 |
Dec 1992 |
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863526 |
Apr 1992 |
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626814 |
Dec 1990 |
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Continuation in Parts (1)
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62693 |
May 1993 |
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