Claims
- 1. A method of treating an HIV infection in a human having an HIV infection which comprises orally administering to said human in a capsule or tablet unit dose, 1 to 15 mg per kilogram human body weight per day of the compound 5-chloro-1-(2,3-dideoxy-3-fluoro-.beta.-D-erythro-pentofuranosyl)uracil, said compound being given to said human 2 to 6 times per day and each capsule or tablet containing 10 to 1500 mg of the compound.
- 2. A method of treating an HIV infection in a human having an HIV infection which comprises administering to said human 1 to 15 mg per kilogram human bodyweight per day of the compound 5-chloro-1-(2,3-dideoxy-3-fluoro-.beta.-D-erythropentofuranosyl)uracil.
- 3. A method according to claim 2 in which the compound is administered two to six times per day in sub doses.
- 4. A method according to claim 3 in which each sub dose contains 50 to 700 mg of the compound.
- 5. The method of claim 2 in which the compound is administered orally.
- 6. The method of claim 3 in which the compound is administered orally.
- 7. A method of treating an HIV infection in a human which comprises administering to said human an effective HIV treatment amount of the compound 5-chloro-1-(2,3-dideoxy-3-fluoro-.beta.-D-erythro-pentofuranosyl)uracil in a tablet or capsule formulation.
- 8. A method of treating an HIV infection in a human which comprises injecting a liquid formulation containing an effective HIV treatment amount of the compound 5-chloro-1-(2,3-dideoxy-3-fluoro-.beta.-D-erythro-pentofuranosyl)uracil into said human.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8762136 |
Nov 1987 |
GBX |
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Parent Case Info
This is a continuation of application Ser. No. 07/709,083 filed on May 30, 1991, now abandoned, which is a continuation of Ser. No. 07/267,244 filed Nov. 4, 1988 now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3328388 |
Shen et al. |
Jun 1967 |
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5153180 |
Mattes et al. |
Oct 1992 |
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Foreign Referenced Citations (1)
Number |
Date |
Country |
WO8800050 |
Jan 1988 |
WOX |
Non-Patent Literature Citations (3)
Entry |
Matthes et al., "3'-Fluoro-substituted Deoxynucleosides As Potential Anti-AIDS Drugs", paper presented at symposium on AIDS, Berlin, Sep. 7-10, 1988. |
Jan Balzarini, et al.; 5-Halogeno-3'-fluoro-2', 3'-dideoxyuridines as Inhibitors of Human Immunodeficiency Virus (HIV); Potent and Selective Anti-HIV Acitivity of 3'-Fluoro-2',3'-dideoxy-5-chlorouridine; 1989; pp. 571-577. |
Susan Daluge et al.; 5-Chloro-2',3-Dideoxy-3'Fluorouridine (935U83), a Selective Anti-Human Immunodeficiency Virus Agent with and Improved Metabolic and Toxicological Profile; Vo. 38; No. 7; May 9, 1994; pp. 1590-1603. |
Continuations (2)
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Number |
Date |
Country |
Parent |
709083 |
May 1991 |
|
Parent |
267244 |
Nov 1988 |
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