Claims
- 1. A method for the treatment of hormone dependent mammary carcinoma, carcinoma of the prostate and endometrial carcinoma which comprises administering an effective amount of a compound of the formula: ##STR43## wherein R.sub.1 is hydrogen, a hydroxy group or a C.sub.2 -C.sub.6 alkanoyloxy group, R.sub.2 is a hydrogen or halogen atom, R.sub.3 is a hydrogen or a C.sub.1 -C.sub.6 alkyl group, R.sub.4 is a hydroxy group or a C.sub.2 -C.sub.6 alkanoyloxy group, R.sub.5 is hydrogen or a halogen atom and R.sub.6 is hydrogen or a halogen atom, Alk is a C.sub.2 -C.sub.10 alkylene chain where 4 neighboring CH.sub.2 groups may also be replaced by a 1,4-phenylene ring, A--B is the group HN--CH.sub.2 --CH.sub.2 --NH.sub.2, H.sub.2 N--CH.sub.2 --CH--CH.sub.2 --NH.sub.2 or ##STR44## and R.sub.7 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a phenyl racical and X stands for the equivalent of a physiologically acceptable anion.
- 2. A pharmaceutical preparation comprising a pharmaceutically acceptable carrier, diluent or auxiliary substance and an amount effective for the treatment of mammary carcinoma of a compound of the formula: ##STR45## wherein R.sub.1 is hydrogen, a hydroxy group or a C.sub.2 -C.sub.6 alkanoyloxy group, R.sub.2 is a hydrogen or a halogen atom, R.sub.3 is hydrogen or a C.sub.1 -C.sub.6 alkyl group, R.sub.4 is a hydroxy group or a C.sub.2 -C.sub.6 alkanoyloxy group, R.sub.5 is hydrogen or a halogen atom and R.sub.6 is hydrogen or a halogen atom, Alk is a C.sub.2 -C.sub.10 alkylene chain where 4 neighboring CH.sub.2 groups may also be replaced by a 1,4-phenylene ring, A--B is the group HN--CH.sub.2 --CH.sub.2 --NH.sub.2, H.sub.2 N--CH.sub.2 --CH--CH.sub.2 --NH.sub.2 or ##STR46## and R.sub.7 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a phenyl radical and x stands for the equivalent of a physiologically acceptable anion.
Priority Claims (1)
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3633673 |
Oct 1986 |
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Parent Case Info
This is a division of application Ser. No. 07/438,984, filed Nov. 20, 1989 now U.S. Pat. No. 4,992,553 which is a continuation of application Ser. No. 07/104,135 filed Oct. 5, 1987, and now abandoned.
Foreign Referenced Citations (3)
Number |
Date |
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2111478 |
May 1983 |
GBX |
2128615 |
Jul 1984 |
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2147278 |
Apr 1985 |
GBX |
Non-Patent Literature Citations (7)
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T. A. Connors et al Platinum Coordination Complexes in Cancer Chemotherapy, Berlin, 1974, pp. 132-136. |
Sandra J. Meischen et al, Journ. Nat. Cancer Inst. 57, (1976) pp. 841-845. |
Sarma et al., Chem-Biol Interactions, 46 (1983) pp. 219-232. |
Synthesis and Spectroscopic Studies of Potential Anticancer [Platinum(II)(2,2'-Bipyridine)(Amino Acid)].sup.n+ (n=1 or 2) Complexes; Kumar, et al; Journal of Inorganic Biochemistry 23, 1-11 (1985). |
Bowler, J.A.C.S. 106, 6102 (1984). |
Haggins, Cancer Res. 25(1965) 1163-7. |
Cancer Treatment Review 3, 205(1976). |
Divisions (1)
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438984 |
Nov 1989 |
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Continuations (1)
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104135 |
Oct 1987 |
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