Claims
- 1. A method of reducing ischemia/reperfusion injury comprising;
selecting a subject at risk for an ischemic event; and administering to a subject a therapeutically effective dose of at least one nitroxyl anion donating compound wherein the compound is administered prior to the onset of ischemia.
- 2. The method of claim 1, wherein the nitroxyl anion donating compound is a nitroxyl-donating diazeniumdiolate.
- 3. The method of claim 2, wherein the nitroxyl-donating diazeniumdiolate has the formula
- 4. The method of claim 3, wherein J is oxide.
- 5. The method of claim 3, wherein J is lower alkyl.
- 6. The method of claim 3, wherein J is amine.
- 7. The method of claim 6, wherein J is primary amine.
- 8. The method of claim 7, wherein the nitroxyl-donating diazeniumdiolate has the formula
- 9. The method of claim 8, wherein R is alkyl.
- 10. The method of claim 9, wherein R is lower alkyl.
- 11. The method of claim 10, wherein R is isopropyl.
- 12. The method of claim 1, wherein the ischemia/reperfusion injury is an injury of the myocardium or brain.
- 13. The method of claim 12, wherein the ischemia/reperfusion injury is an injury of the myocardium.
- 14. The method of claim 13, wherein the size of infarction is reduced by about 35% or more.
- 15. The method of claim 14, wherein the size of infarction is reduced by about 35% to about 55%.
- 16. The method of claim 1, wherein selecting a subject at risk of an ischemic event comprises selecting a subject with no evidence of current ischemia.
- 17. A method of reducing ischemia/reperfusion injury comprising, administering a dose of at least one nitroxyl donating compound to an organ that is to be transplanted, wherein the dose is effective to reduce ischemia/reperfusion injury upon reperfusion of the organ in a recipient.
- 18. The method of claim 17, wherein the nitroxyl anion donating compound is a nitroxyl-donating diazeniumdiolate.
- 19. The method of claim 18, wherein the nitroxyl-donating diazeniumdiolate has the formula
- 20. The method of claim 19, wherein J is oxide.
- 21. The method of claim 19, wherein J is lower alkyl.
- 22. The method of claim 19, wherein J is amine.
- 23. The method of claim 22, wherein J is primary amine.
- 24. The method of claim 23, wherein the nitroxyl-donating diazeniumdiolate has the formula
- 25. The method of claim 24, wherein R is alkyl.
- 26. The method of claim 25, wherein R is lower alkyl.
- 27. The method of claim 26, wherein R is isopropyl.
CROSS REFERENCE TO RELATED APPLICATION
[0001] This application claims the benefit of the earlier filing dates of prior U.S. Provisional Patent Application No. 60/388,819, filed Jun. 14, 2002, and U.S. Provisional Patent Application No. 60/389,757, filed Jun. 17, 2002. Applicants' prior provisional applications are incorporated herein by reference.
Provisional Applications (2)
|
Number |
Date |
Country |
|
60388819 |
Jun 2002 |
US |
|
60389757 |
Jun 2002 |
US |