Claims
- 1. A method for treating a neutrophil-associated pulmonary disease comprising locally administering to the respiratory tract of an afflicted human an amount of a therapeutic preparation comprising a topical anesthetic effective to counteract the symptoms of the disease, wherein the topical anesthetic is an aminoalkylbenzoate.
- 2. The method of claim 1 wherein the therapeutic preparation is administered in combination with a pharmaceutically acceptable liquid vehicle.
- 3. The method of claim 1 wherein the therapeutic preparation is administered by spraying or by nebulization.
- 4. The method of claim 1 wherein the topical anesthetic is administered at a daily dose of about 2.0-15 m/kg.
- 5. The method of claim 1 wherein the topical anesthetic is an ester between a carboxylic acid of the general formula:
- 6. The method of claim 1 wherein the topical anesthetic is an aminoalkylbenzoate or a pharmaceutically acceptable salt thereof.
- 7. The method of claim 1 wherein the topical anesthetic is procaine, chloroprocaine, dyclonine, tetracaine, benoxinate, proparacaine, meprylcaine, piperocaine, or a pharmaceutically acceptable salt thereof.
- 8. The method of claim 1 wherein the neutrophil-associated pulmonary disease is chronic obstructive pulmonary disease (COPD), chronic bronchitis (CB), cystic fibrosis, α-1 anti-trypsin deficiency, pulmonary emphysema, adult respiratory distress syndrome, or idiopathic pulmonary fibrosis.
RELATED APPLICATION
[0001] This application is a divisional under 37 C.F.R. 1.53(b) of U.S. patent application Ser. No. 10/326,224 filed Dec. 20, 2002, which is a continuation under 35 U.S.C. 111(a) of International Application No. PCT/US01/19977 filed Jun. 22, 2001 and published in English as WO 02/00218 A2 on Jan. 3, 2002, which claimed priority from U.S. Provisional Application Serial No. 60/214,031 filed Jun. 23, 2000, which applications and publication are incorporated herein by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60214031 |
Jun 2000 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
10326224 |
Dec 2002 |
US |
Child |
10683808 |
Oct 2003 |
US |
Continuations (1)
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Number |
Date |
Country |
Parent |
PCT/US01/19977 |
Jun 2001 |
US |
Child |
10326224 |
Dec 2002 |
US |