Claims
- 1. A method of treating osteoporosis by stimulating intestinal calcium transport activity with attendant bone formation without significantly increasing bone calcium mobilization activity comprising administering to a patient an effective amount of 1.alpha.,25-dihydroxy-22(E)-dehydro-vitamin D.sub.3.
- 2. The method of claim 1 wherein the osteoporosis is postmenopausal osteoporosis.
- 3. The method of claim 1 wherein the osteoporosis is senile osteoporosis.
- 4. The method of claim 1 wherein the osteoporosis is steroid-induced osteoporosis.
- 5. The method of claim 2 wherein the vitamin D.sub.3 compound is administered to women during and subsequent to menopause.
- 6. The method of claim 1 wherein the vitamin D.sub.3 compound is administered to a women in need thereof prior to the onset of menopause.
- 7. The method of claim 1 wherein the vitamin D.sub.3 compound is administered in an amount from about 0.5 micrograms to about 3 micrograms per day.
- 8. The method of claim 1 wherein the vitamin D.sub.3 compound, in solution in a liquid vehicle ingestible by and nontoxic to said patient, is administered orally in encapsulated form.
- 9. The method of claim 1 wherein the vitamin D.sub.3 compound is administered in a slow release formulation.
- 10. The method of claim 1 wherein the vitamin D.sub.3 compound is administered daily in divided dosages.
Parent Case Info
This application is a continuation of application Ser. No. 07/873,389, filed Apr. 24, 1992, now abandoned.
Government Interests
This invention was made with United States Government support awarded by the National Institute of Health (NIH), Grant No. DK 14881. The United States Government has certain rights in this invention.
US Referenced Citations (16)
Non-Patent Literature Citations (2)
Entry |
J. Nutr. Biochem., vol. No. 1, Jan. 1993, pp. 49-57, Tai C. Chen et al, "An Evaluation of 1,25-Dihydroxyvitamin D.sub.3 Analogues on the Proliferation and Differentiation of Cultured Human Keratinocytes, Calcium Metabolism and the Differentiation of Human HL-60 Cells". |
Arch. Toxicol, vol. 63, No. 5, 1989, pp. 394-400, Andreas Istler et al, "Effects of vitamin D Derivatives on Soft Tissue Calcification in Neonatal and Calcium Mobilization in Adult Rats". |
Continuations (1)
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Number |
Date |
Country |
Parent |
873389 |
Apr 1992 |
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