Claims
- 1. A method of treating psychosis in a patient in need of such treatment comprising administering to the patient a tetrahydrocarbazole derivative of the formula ##STR10## wherein, Thc is 1,2,3,4-tetrahydro-3-carbazolyl, 1,2,3,4-tetrahydro-3-carbazolyl substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 or CN or by a methylenedioxy group;
- the two radicals Y together form a C--C bond;
- one radical Z is Ar and the other radical Z is H;
- A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 --; and
- Ar is phenyl, phenyl substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 or CN or by a methylenedioxy group, or is 2- or 3-thienyl;
- all alkyl groups each have 1-4 C atoms;
- or a physiologically acceptable acid addition salt thereof.
- 2. A method of claim 1 wherein the compound is selected from
- (a) 3-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridylmethyl)-1,2,3,4-tetrahydrocarbazole;
- (b) 3-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridylmethyl)-6-hydroxy-1,2,3,4-tetrahydrocarbazole; or
- (c) 3-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridylmethyl)-7-hydroxy-1,2,3,4-tetrahydrocarbazole.
- 3. A method of claim 1, wherein each alkyl is methyl.
- 4. A method of claim 1, wherein Thc is unsubstituted.
- 5. A method of claim 1, wherein Thc is substituted once, in the 6- or 7-position by --CH.sub.3, --C.sub.2 H.sub.5, --OCH.sub.3, --OC.sub.2 H.sub.5, --SCH.sub.3, --SC.sub.2 H.sub.5, OH, F, Cl, Br, --CF.sub.3 or --CN.
- 6. A method of claim 1, wherein A is --CH.sub.2 --.
- 7. A method of claim 1, wherein Ar is phenyl.
- 8. A method of claim 1, wherein Ar is monosubstituted by --CH.sub.3, F, Cl, Br or --CF.sub.3.
- 9. A method of claim 1, wherein Thc is 1,2,3,4-tetrahydro-3-carbazoyl, methyl-1,2,3,4-tetrahydro-3-carbazolyl, methoxy-1,2,3,4-tetrahydro-3-carbazolyl, dimethoxy-1,2,3,4-tetrahydro-3-carbazolyl, hydroxy-1,2,3,4-tetrahydro-3-carbazolyl, dihydroxy-1,2,3,4-tetrahydro-3-carbazolyl, fluoro-1,2,3,4-tetrahydro-3-carbazolyl, chloro-1,2,3,4-tetrahydro-3-carbazolyl, dichloro-1,2,3,4-tetrahydro-3-carbazolyl, bromo-1,2,3,4-tetrahydro-3-carbazolyl, cyano-1,2,3,4-tetrahydro-3-carbazolyl or methylenedioxy-1,2,3,4-tetrahydro-3-carbazolyl, and the substituents are in the 6- or 7-position.
- 10. A method of claim 1, wherein Thc is 1,2,3,4-tetrahydro-3-carbazolyl, 6- or 7-methyl-1,2,3,4-tetrahydro-3-carbazolyl, 6,7-dimethyl-1,2,3,4-tetrahydro-3-carbazolyl, 6- or 7-methoxy-1,2,3,4-tetrahydro-3-carbazolyl, 6,7-dimethoxy-1,2,3,4-tetrahydro-3-carbazolyl, 6- or 7-chloro-1,2,3,4-tetrahydro-3-carbazolyl, 6- or 7-hydroxy-1,2,3,4-tetrahydro-3-carbazolyl, 6,7-dihydroxy-1,2,3,4-tetrahydro-3-carbazolyl or 6,7-methylenedioxy-1,2,3,4-tetrahydro-3-carbazolyl.
- 11. A method of claim 1, wherein Ar is phenyl, tolyl, methoxyphenyl, fluorophenyl, chlorophenyl, trifluoromethylphenyl or chlorotrifluoromethylphenyl.
- 12. A compound of claim 1, wherein Thc is 1,2,3,4-tetrahydro-3-carbazolyl, 6- or 7-methoxy-1,2,3,4-tetrahydro-3-carbazolyl, 6- or 7-hydroxy-1,2,3,4-tetrahydro-3-carbazolyl, 6,7-dimethoxy-1,2,3,4-tetrahydro-3-carbazolyl, 6- or 7-chloro-1,2,3,4-tetrahydro-3-carbazolyl or 6,7-dihydroxy-1,2,3,4-tetrahydro-3-carbazolyl.
- 13. A method of claim 1, wherein Thc is 1,2,3,4-tetrahydro-3-carbazolyl, or 6- or 7-hydroxy-1,2,3,4-tetrahydro-3-carbazolyl.
- 14. A method of claim 1, wherein the daily dosage is 0.001 to 10 mg/kg of body weight.
Priority Claims (2)
Number |
Date |
Country |
Kind |
3300094 |
Jan 1983 |
DEX |
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3336643 |
Oct 1983 |
DEX |
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Parent Case Info
This is a continuation of application Ser. No. 747,594 filed July 24, 1985, abandoned, which is a divisional of Ser. No. 568,310 of Jan. 4, 1984 now U.S. Pat. No. 4,547,576.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3634420 |
Littell et al. |
Jan 1972 |
|
3740404 |
Littell et al. |
Jun 1973 |
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3752823 |
McManus |
Aug 1973 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
0077607 |
Apr 1983 |
EPX |
1299041 |
Dec 1972 |
GBX |
Divisions (1)
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Number |
Date |
Country |
Parent |
568310 |
Jan 1984 |
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Continuations (1)
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Number |
Date |
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Parent |
747594 |
Jul 1985 |
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