Claims
- 1. A method of treating a tumor susceptible to 4'-epi-doxorubicin, 4'-desoxy-doxorubicin, daunorubicin or 4'-demethoxy-daunorubicin therapy in a patient in need of such treatment, which comprises administering to the patient a tumor growth-inhibiting amount of a sterile injectable solution comprising water, an anti-tumor effective amount of 4'-epi-doxorubicin, 4'-desoxy-doxorubicin, daunorubicin or 4'-demethoxy-daunorubicin or a pharmaceutically acceptable salt thereof; and a cosolubilizing agent selected from the group consisting of a hydroxy-, mercapto-, or amino-substituted benzoic acid, an alkali metal salt thereof, a C.sub.1 -C.sub.4 alkyl ester thereof, a ring-halogenated methyl-substituted phenol, an amino acid, and mixtures thereof; said solution being produced by reconstituting a lyophilized preparation comprising said 4'-epi-doxorubicin, 4'-deoxy-doxorubicin, daunorubicin or 4'-demethoxy-daunorubicin, or a pharmaceutically acceptable salt thereof, and said cosolubilizing agent.
- 2. A method according to claim 1, wherein the pharmaceutically acceptable salt is a hydrochloride salt.
- 3. A method according to claim 1, wherein the cosulubilizing agent is selected from the group consisting of p-hydroxy-benzoic acid and the methyl ester thereof, p-amino-benzoic acid and the methyl ester thereof, o-hydroxy-benzoic acid and the methyl ester thereof, 3-methyl-4-chlorophenol and 3,5-dimethyl-4-chlorophenol.
- 4. A method according to claim 1, wherein the cosolubilizing agent is p-hydroxy-benzoic acid methyl ester.
- 5. A method according to claim 1, wherein the lyophilized preparation additionally includes an inert excipient.
- 6. A method according to claim 5, wherein the inert excipient is lactose.
- 7. A method according to claim 1, wherein the lyophilized preparation is reconstituted with physiological saline solution.
Priority Claims (1)
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8426672 |
Oct 1984 |
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Parent Case Info
This application is a continuation of Ser. No. 453,268 filed 12/21/89, now abandoned, which is a continuation of Ser. No. 326,432, filed 3/20/89 now abandoned, which is a continuation of Ser. No. 158,107, filed 2/16/88 now abandoned, which is a continuation in part of Ser. No. 894,048 filed 8/7/86, now abandoned which is in turn a divisional of Ser. No. 788,158 filed 10/16/85, now U.S. Pat. No. 4,675,311.
Foreign Referenced Citations (1)
Number |
Date |
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2124224 |
Feb 1984 |
GBX |
Non-Patent Literature Citations (3)
Entry |
Chemical Abstracts, vol. 104, No. 6, Feb. 10, 1986, p. 382, No. 39716d, Columbus, Ohio and JP-A-60 92 212 (Kyowa Hakko Kogyo Co. Ltd.) 23-05-1985. |
Pharmazeutische Technologie, G. Thieme, Verlag Stuttgart 1978, p. 621; Sucker. |
Abstracts relating to above. |
Divisions (1)
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Date |
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788158 |
Oct 1985 |
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Continuations (3)
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453268 |
Dec 1989 |
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Parent |
326432 |
Mar 1989 |
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Parent |
158107 |
Feb 1988 |
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Continuation in Parts (1)
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894048 |
Aug 1986 |
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