Claims
- 1. A method of treating ulcers or hypersecretion in a mammal which comprises administering to said mammal an effective anti-ulcer amount of a compound of formula I ##STR3## wherein Y is ##STR4## wherein R is hydrogen or lower alkyl, R.sup.1 is hydrogen, lower alkyl, hydroxylower alkyl, loweralkoxyloweralkyl, loweralkoxy, halogen, formyl, phenyl, phenylalkyl or CH(OR.sup.4).sub.2 where R.sup.4 is lower alkyl or two R.sup.4 radicals are joined to form a lower alkylene chain, m is 1 or 2, the dotted lines in formula V represent an optional double bond in one of the indicated positions, the nitrogen atom carrying a positive charge when a double bond is in the position adjacent thereto, A is an alkylene radical having from 1 to 6 carbon atoms, which may be substituted by lower alkyl of 1 to 6 carbon atoms, S is sulphur, R.sup.3 is loweralkyl, phenyl or aralkyl of 7 to 12 carbon atoms, Z.sup.- is an anion, or a pharmaceutically acceptable acid addition salt thereof, with the proviso that when more than one R.sup.1 radical is present in the molecule then the R.sup.1 radicals may be the same or different.
- 2. A method as claimed in claim 1 wherein the compound of formula I is 1-methyl-2-[piperidinoethyl)thio]pyridinium chloride or a pharmaceutically acceptable acid addition salt thereof.
Priority Claims (1)
Number |
Date |
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Kind |
48813/78 |
Dec 1978 |
GBX |
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Parent Case Info
This is a division of application Ser. No. 217,925 filed Dec. 18, 1980 now U.S. Pat. No. 4,343,805 which is a continuation of Ser. No. 98,421 filed Nov. 29, 1979 now abandoned.
Foreign Referenced Citations (2)
Number |
Date |
Country |
650361 |
Mar 1964 |
BEX |
63-1067 |
Aug 1963 |
ZAX |
Divisions (1)
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Number |
Date |
Country |
Parent |
217925 |
Dec 1980 |
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Continuations (1)
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Number |
Date |
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Parent |
98421 |
Nov 1979 |
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