Patent Application
20220387469
The present disclosure is related to a method of utilizing ultrafine bubbles.
Conventionally, a technique in which a liquid that contains extremely fine bubbles is caused to adhere on the surface of a human body by application etc., to realize a specific function unique to the type of liquid is known, as disclosed in Japanese Unexamined Patent Publication No. 2006-289236, Japanese Unexamined Patent Publication No. 2010-201397, and Japanese Re-Publication of PCT International Application No. 2011/16529, for example.
Specifically, Japanese Unexamined Patent Publication No. 2006-289236 discloses that plasma discharge processed water, which is a high concentration ozone water, may be utilized as a cosmetic liquid as is, or utilized as a raw material for various cosmetic liquids such as a cosmetic moisturizing liquid and a cosmetic milky lotion. In addition, Japanese Unexamined Patent Publication No. 2006-289236 discloses that the plasma discharge processed water exhibits superior permeability into skin as well as high moisturizing effects (refer to paragraphs 0040 and 0043). Further, Japanese Unexamined Patent Publication No. 2006-289236 discloses that a technique in which ozone is caused to be in a state of a great number of ultrafine bubbles called microbubbles, nanobubbles, etc., and blown into water is known as a method for obtaining the high concentration ozone water (refer to paragraph 0002).
In addition, Japanese Unexamined Patent Publication No. 2010-201397, which is related to a method for producing fine bubbles, discloses that the effects of utilizing hot water that contains a great number of fine bubbles include removal of dirt from within pores of the skin, as well as removal of dirt, oil, and fats from hair due to the high permeability thereof (refer to paragraph 0027). Japanese Unexamined Patent.
Publication No. 2010-201397 also discloses that hot water that exhibits the aforementioned effects is that in which fine bubbles having diameters of less than or equal to 500 nm, particularly diameters within a range from 100 to 300 nm, are generated, and that these types of fine bubbles encompass the concept of microbubbles, micro nanobubbles, and nanobubbles (refer to paragraphs 0030 and 0031).
Further, Japanese Re-Publication of PCT International Application No. 2011/16529 discloses a method for providing a dispersion that does not contain a surfactant within a mixture of a dispersed substance and a liquid dispersion medium by utilizing an ultrafine bubble generating apparatus. This method produces a composition that contains ultrafine bubbles having a modal particle diameter of less than or equal to 500 nm, a hydrophobic medicament, and water. Japanese Re-Publication of PCT International Application No. 2011/16529 also discloses that in such a composition, the effects of the medicament are more favorably expressed due to the ultrafine bubbles also being present. In the case that the medicament has transpiration properties, the transpiration performance improves. In the case that the medicament is an antifungal agent, etc., the permeability into the skin thereof improves (refer to paragraphs 0015 and 0016). Japanese Re-Publication of PCT International Application No. 2011/16529 lists various pharmaceutical preparations and cosmetics as examples of the medicament (refer to paragraph 0021).
Note that in Japanese Unexamined Patent Publication No. 2006-289236, Japanese Unexamined Patent Publication No. 2010-201397, and Japanese Re-Publication of PCT International Application No. 2011/16529, the terms microbubbles, micro nanobubbles, and nanobubbles are employed with respect to the fine bubbles or the ultrafine bubbles which are included in a liquid such as water. Currently, fine bubbles having particle diameters of less than or equal to 1000 nm are defined as “ultrafine bubbles” by ISO/TC281 (Fine Bubble Technology). The present disclosure is related to fine bubbles having particle diameters of less than or equal to 1000 nm, and therefore these fine bubbles will be referred to as “ultrafine bubbles”.
Meanwhile, the apparatuses which are disclosed in Japanese Re-Publication of PCT International Application No. 2011/16529 are known as apparatuses that generate the aforementioned ultrafine bubbles within a liquid such as water. The apparatuses which are exemplified in Japanese Re-Publication of PCT International Application No. 2011/16529 are those that apply the static mixing method, the venturi method, the cavitation method, the vapor agglomeration method, the ultrasound method, the spiral flow method, the pressurized dissolving method, the fine pore method, and the gas liquid mixture shearing method. Further, the apparatuses which are disclosed in Japanese Patent No. 6077627 and Japanese Patent No. 6490317, for example, are also known. The apparatuses which are disclosed in these documents are equipped with a rotatable shaft, on the outer peripheral surface of which a plurality of pyramidal protrusions or rectangular blades are mounted, and a housing pipe such as a water pipe through which liquids are capable of flowing, the rotatable shaft being provided within the housing pipe.
The present disclosure provides a method that improves the permeability of external skin agents into skin in cases that external skin agents such as cosmetics are applied onto the skin.
The present disclosure improves the permeability of external skin agents into skin by utilizing the aforementioned ultrafine bubbles. That is, the method of utilizing ultrafine bubbles according to the present disclosure applies a liquid that contains ultrafine bubbles onto a portion of the skin onto which an external skin agent that contains a specific component to the skin of the human body is to be applied, or applies an external skin agent that contains ultrafine bubbles onto the skin, in order to promote permeation of the specific component into the skin.
Note that it is desirable for the method of utilizing ultrafine bubbles according to the present disclosure to be applied in the case that the specific component is adenosine.
In addition, in the method of utilizing ultrafine bubbles according to the present disclosure, it is particularly desirable for the principal component of the liquid that contains ultrafine bubbles to be water. The expression “principal component” refers to the component having the greatest percentage by weight from among a plurality of components.
Further, examples of the external skin agent to be employed in the method of utilizing ultrafine bubbles according to the present disclosure include cosmetics and external pharmaceutical preparations, for example.
The method of utilizing ultrafine bubbles according to the present disclosure applies a liquid that contains ultrafine bubbles onto a portion of the skin onto which an external skin agent is to be applied to the skin, or applies an external skin agent that contains ultrafine bubbles onto the skin. Therefore, permeation of the specific component which is contained in the external skin agent into the skin is promoted by the function of the ultrafine bubbles.
Hereinafter, an embodiment of the present disclosure will be described with reference to the attached drawings.
Here, a spray actuator which has a flow rate adjusting mechanism is applied as the spray actuator 11. Specifically, actuator “D391” by K. K. Mitani Valves, which has a flow rate adjusting mechanism is applied in the present embodiment. The detailed configurations of this type of actuator which has a flow rate adjusting mechanism and aerosol containers that employ such actuators are disclosed in Japanese Patent Nos. 4217049, 4350970, and 4974175, for example. In the present embodiment, the spray actuator 11 and the aerosol container 10 can be favorably employed as disclosed in these publications.
That ultrafine bubbles are generated within a liquid in the case that the liquid is sprayed from the spray actuator 11 and the aerosol container 10 was empirically confirmed. The results of the confirmation will be described in detail below. In this experiment, “SALD-7100HH”, which is a laser diffraction particle size distribution measuring apparatus produced by K. K. Shimadzu, was utilized to confirm the generation of ultrafine bubbles. The principles of measurement conducted by this laser diffraction particle size distribution measuring apparatus will be described with reference to
In this apparatus, a laser beam L emitted from a laser light source 21 is collimated by a collimating lens 22, and then is irradiated onto a group of particles 23 which are targets of measurement. In the case of the present example, if a great number of ultrafine bubbles have been generated within the liquid, the ultrafine bubbles will be the group of particles 23. When the laser beam L is irradiated onto the group of particles 23, diffracted/scattered light will be generated toward the back (toward the laser light source 21), the sides, and the front from the group of particles 23. The diffracted/scattered light expresses a predetermined spatial pattern (light intensity distribution pattern) within planes that intersect with the propagation directions thereof. It is known that light intensity distribution patterns are expressed as various shapes depending on the sizes of the particles. Therefore, the percentages of particles and the sizes of particles which are contained (particle size distribution) can be obtained, by detecting and analyzing the light intensity distribution pattern.
In greater detail, this apparatus converges light from the group of particles 23 with a light condensing lens 24 to obtain a diffracted/scattered light image 25. Back scattered light from the group of particles 23 is detected by back scattered light sensors 26, side scattered light from the group of particles 23 is detected by side scattered light sensors 27, and front scattered light from the group of particles 23 is detected by front scattered light sensors 28, and the light intensities of light scattered in each of the directions were obtained. Note that in
Note that the light intensities which are measured by each of the sensors 26, 27, and 28 will be of higher values as the concentration of the group of particles 23, that is, the ultrafine bubbles, is greater.
The curve indicated by the broken line in
The light intensities indicated by the sensors 26, 27, and 28 were measured in the manner described above. In the present example, a total of 70 sensors were provided as each of the sensors 26, 27, and 28. Each sensor was designated by a unique element number from “1 through 70”, and the light intensities indicated by each of the sensors were measured. The measurement results are shown in
There are cases in which the particle size distribution obtained by the laser diffraction/scattering method fluctuate greatly depending on sample conditions, etc. Meanwhile, the local maximum value and the profile of scattered light intensity faithfully reflect the concentration of fine bubbles if the fine bubble generating conditions are the same. Therefore, the local maximum value of scattered light intensity was designated as an index of evaluates the relative concentration of fine bubbles which are contained in the liquid. In both a case in which ultrafine bubbles were generated by aerosol spray and a case in which ultrafine bubbles were generated by employing a pressurized dissolving bubble generator, the scattered light profiles were those having a local maximum in the vicinities of the sensors with element numbers 43 through 45. In addition, element numbers 43 through 45 generally reflect light scattered by particles having particle sizes within a range from 100 to 200 nm that indicate the local maximum value of the number distribution of ultrafine bubbles, regardless of the method by which ultrafine bubbles were generated.
Based on the measurement results of
The above light intensity was measured by changing state of the aerosol container 10 in the following four different states, and in each case, Formulation 1 to be described later was sprayed from the aerosol container 10. The above four states are described below. In
As illustrated in
In addition,
Note that the method of utilizing ultrafine bubbles according to the present disclosure is capable of significantly improving the permeability into the skin of the specific component in the case that the specific component contained in the external skin agent is adenosine. The results of empirical confirmation of this point will be described below. Formulation 1 and a Formulation 2 that contains adenosine were prepared in order to compare the permeabilities thereof. The ingredients of each of the formulations are listed below, and the component ratios are indicated in percentages by mass.
In order to provide Formulation 1 that contains ultrafine bubbles onto the skin, the aerosol container 10 was filled with Formulation 1, and the interior pressure was set to 0.9 MPa with nitrogen gas. The actuator “D391” having a flow rate adjusting mechanism produced by K. K. Mitani Valves was applied as the spray actuator 11. In contrast, to provide Formulation 1 that does not contain ultrafine bubbles onto the skin, Formulation 1 was utilized as an undiluted liquid.
That is, a liquid which was sprayed from the aerosol container 10 and Formulation 1 as an undiluted liquid were applied to two different locations on a forearm of a test subject. Thereafter, Formulation 2 that contains adenosine was applied onto each of the two locations for 10 minutes. Next, 1 cm by 1 cm squares of stratum corneum were peeled from the locations onto which the formulations were applied, stratum corneum components were extracted, and the amounts of adenosine were quantitatively analyzed by the LC-MS method (Liquid Chromatography Mass Spectrometry method). The amounts of adenosine within the stratum corneum which were quantitively analyzed indicated that the amount of adenosine was 1.6 times greater in the case that Formulation 1 that contains ultrafine bubbles was applied, compared to the case that Formulation 1 that did not contain ultrafine bubbles was applied. Thereby, the effect of significantly improving the permeability of adenosine due to the utilization of ultrafine bubbles was confirmed.
If Formulation 1 is sprayed from the aerosol container 10 employing the actuator “D391” having the flow rate adjusting mechanism as the spray actuator 11 in the manner described above, the sprayed aerosol liquid becomes a liquid that contains a great amount of fine bubbles having particle diameters of less than or equal to 1000 nm, that is ultrafine bubbles. By applying the sprayed liquid that contains ultrafine bubbles onto the back of the right hand 1R and then applying Formulation 2 thereafter in this manner, an effect that permeation of the specific component within Formulation 2, for example, adenosine, is promoted is obtained. Particularly, in the present embodiment, the sprayed liquid that contains ultrafine bubbles is generated by a simple operation of the aerosol container 10, and therefore application of the liquid that contains ultrafine bubbles is facilitated. Note that the liquid that contains ultrafine bubbles may be produced by a method other than by aerosol spraying.
Note that the sprayed liquid that contains ultrafine bubbles may be directly sprayed and applied from the aerosol container 10 onto a surface where the liquid is utilized (the back of the right hand 1R in the present embodiment) as described above. Alternatively, the sprayed liquid may be sprayed and applied onto a cotton ball for cosmetics or the like, and then the cotton ball for cosmetics or the like may be employed to apply the sprayed liquid onto a utilization surface. Such a manner of application is particularly favorable in the case that the utilization surface of the liquid is the scalp, or areas in the vicinities of the eyes, nose, or ears.
In addition, the method of utilizing ultrafine bubbles according to the present disclosure is also applicable for a case in which the cosmetic to be applied to human skin is a cosmetic other than Formulation 2, and further for cases in which an external skin agent other than a cosmetic, such as an external pharmaceutical preparation, is to be applied to the skin. In such cases as well, the same effects as those which are described above are exhibited.
Further, the liquid that contains ultrafine bubbles is applied to the skin prior to the external skin agent being applied in the embodiment described above. Alternatively, an external skin agent that contains ultrafine bubbles may be applied to the skin. In this case as well, the same effects can be obtained.
Here, another embodiment of a liquid that contains ultrafine bubbles and is utilizable as the present disclosure will be described. The liquid constituted by Formulation 1 and Formulation 2 described above will be referred to as Example 1. Other liquids will be described as Examples 2 through 8 below. Table 1 below shows the components of Examples 2 through 4. In the table, the component ratios of each of the components represent percentages by mass with respect to the entirety of the liquid (the same applies hereinafter).
Next, the components of the liquids of Examples 5 through 8 will be shown below. Each of Examples 5 through 8 are liquids that applies a liquid that contains ultrafine bubbles by spraying Formulation 1 onto the skin and then applying Formulation 2 onto the same location of the skin after Formulation 1 has blended thereinto. That is, Table 2 shows the component ratios of Formulation 1 which is utilized in common in Examples 5 through 8, and Table 3 shows the component ratios of Formulation 2 in each of Examples 5 through 8.
Note that the effective component which is contained in the external skin agent as the specific component may be constituted by a lipophilic compound or may be constituted by a hydrophilic compound. In the case that a permeation promoting agent is utilized with a lipophilic compound, for example, it is generally difficult to blend a component that also improves the permeability of a hydrophilic compound as well in the same type of preparation. The method for utilizing ultrafine bubbles according to the present disclosure employs ultrafine bubbles, which have a low degree of correlation with chemical properties. Therefore, it is possible to efficiently promote the permeation of all of a plurality of effective components. The method of utilizing ultrafine bubbles according to the present disclosure is applicable to a greater range of external skin agents compared to cases in which permeation promoting agents are utilized.
| Number | Date | Country | Kind |
|---|---|---|---|
| 2019-200313 | Nov 2019 | JP | national |
The present application is a National Phase Entry of PCT International Application No. PCT/JP2020/040945 filed on Oct. 30, 2020, which claims priority to Japanese Patent Application No. 2019-200313 filed on Nov. 1, 2019.
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/JP2020/040945 | 10/30/2020 | WO |
