Claims
- 1. An elongate, anhydrous, homogeneous, solid drug composition, said composition comprising a drug, and up to 90% of a carrier, wherein said composition comprises a maximum cross-sectional diameter of less than 0.5 mm, and wherein said drug and said carrier are selected and compounded in a proportion such that said drug is dispersed from said solid, homogeneous composition upon contact with bodily fluids and is distributed within the patient's blood stream to achieve a blood level concentration of said drug that is within 50 percent of a blood level concentration of said drug when administered in a liquid formulation, as measured over time after any initial peaks in concentration have stabilized.
- 2. A composition of claim 1, wherein said composition is in the form of a filament.
- 3. A composition of claim 1, wherein said drug is insulin.
- 4. A composition of claim 1, wherein said carrier is water-soluble.
- 5. A composition of claim 4, wherein said carrier is selected from the group consisting of cellulose, hydroxy propyl methylcellulose, carboxy methylcellulose, hydroxy ethylcellulose, hyaluronic acid, dextrose, mannose, glucose, or gelatin.
- 6. A composition of claim 1, wherein said composition has a surface area to drug ratio of at least 10 square millimeters per milligram of the drug.
- 7. A composition of claim 1, wherein said composition comprises at least 30 percent, by weight, of said drug and up to 70 percent, by weight, of said carrier.
- 8. A composition of claim 1, wherein said composition comprises at least 50 percent, by weight, of said drug and up to 50 percent, by weight, of said carrier.
- 9. A composition of claim 1, wherein said drug is a polypeptide.
- 10. An elongate, anhydrous, solid drug composition of claim 1, said composition consisting essentially of at least 10 percent, by weight, of said drug and up to 90 percent, by weight, of said carrier.
- 11. A composition of claim 10, wherein said composition consists essentially of at least 30 percent, by weight, of said drug and up to 70 percent, by weight, of said carrier.
- 12. A composition of claim 7, wherein said composition consists essentially of at least 50 percent, by weight, of said drug and up to 50 percent, by weight, of said carrier.
- 13. A composition of claim 7, wherein said drug is a polypeptide.
Parent Case Info
This is a continuation of copending application Ser. No. 08/300,138, filed Sep. 2, 1994.
US Referenced Citations (38)
Foreign Referenced Citations (4)
Number |
Date |
Country |
0 139 286 A2 |
May 1985 |
EPX |
0 292 936 A2 |
Nov 1988 |
EPX |
3317536 |
Nov 1984 |
DEX |
WO9323017 |
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WOX |
Non-Patent Literature Citations (1)
Entry |
Campfield et al., Chemical Abstracts, vol. 115, #99281. |
Continuations (1)
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Number |
Date |
Country |
Parent |
300138 |
Sep 1994 |
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