BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to the fields of cellular biology. More particularly, it concerns methods and compositions for the modulation of cellular sensitivity to biologically-active agents.
2. Description of Related Art
Transport Processes
Cells can use a phenomenon called symport to move soluble products across biological membranes. Symport is a form of coupled movement of two solutes in the same direction across a membrane by a single carrier. Examples of proton and sodium-linked symport systems are found in nearly all living systems. The energetics of the transport event depend on the relative size and electrical nature of the gradient of solutes.
Transport processes have been classified on the basis of their energy-coupling mechanisms. Currently there are four classifications: (1) Primary Active Transport which uses either a chemical, light or electrical energy source, (2) Group Translocation which uses chemical energy sources, (3) Secondary Active Transport which uses either a sodium or proton electrochemical gradient energy source, and (4) Facilitated Diffusion which does not require an energy source (Meyers, 1997). The present invention is related to transport molecules belonging to the first class of transport processes, primary active transport, and therefore, this type of transport will be discussed in further detail.
Primary active transport refers to a process whereby a “primary” source of energy is used to drive the active accumulation of a solute into or extrusion of a solute from a cell. Transport proteins include P-type ATPases and ABC-type ATPases, as well as V-type and E-type ATPases. These types of transport systems are found in both eukaryotes and prokaryotes. The bacterial ABC-type transporters, which are ATP-driven solute pumps, have eukaryotic counterparts. Additionally, many transmembrane solute transport proteins exhibit a common structural motif. The proteins in these families consist of units or domains that pass through the membrane six times, each time as an α-helix. This has led to the suggestion that many transport proteins share a common evolutionary origin, but this is not true of several distinct families of transport proteins.
Numerous structurally distinct bacterial permeases, as well as several homologous eukaryotic transport systems, share a common organization (Meyers, 1997). Two hydrophilic domains or proteins function to couple ATP hydrolysis in the cytoplasm to activate substrate uptake or efflux, and two hydrophobic domains or proteins function as the transmembrane substrate channels. These proteins or protein domains constitute what is referred to as the ABC (ATP-binding cassette) superfamily. Either the two hydrophilic domains or proteins or the two hydrophobic domains or proteins (or both) may exist either as heterodimers or homodimers. If, as in most bacterial systems, each of these constituents is a distinct protein, then either two, three, or four genes will code for them, depending on whether both are homodimers, one is a homodimer and one is a heterodimer, or both are heterodimers, respectively. The best characterized of the eukaryotic proteins included in this family are the multidrug-resistance (MDR) transporter and the cystic fibrosis related chloride ion channel of mammalian cells (cystic fibrosis transmembrane conductance regulator or CFTR) (Meyers, 1997).
Multidrug Resistance
Multidrug resistance (MDR) is a general term that refers to the phenotype of cells or microorganisms that exhibit resistance to different, chemically dissimilar, cytotoxic compounds. MDR can develop after sequential or simultaneous exposure to various drugs. MDR can also develop before exposure to many compounds to which a cell or microorganism may be found to be resistant. MDR which develops before exposure is frequently due to a genetic event which causes the altered expression and/or mutation of an ATP-binding cassette (ABC) transporter (Wadkins and Roepe, 1997). This is true for both eukaryotes and prokaryotes.
One prominent member of the ABC family, P-glycoprotein (Pgp; also known as multidrug resistance protein or MDR1), which is a plasma-membrane glycoprotein that confers a multidrug resistance (MDR) phenotype on cells, is of considerable interest because it provides one mechanism of possibly inhibiting resistance in tumor cells to chemotherapeutic agents (Senior et al., 1995). Pgp is a single polypeptide of ˜1280 amino acids with the typical ABC transporter structure profile. Studies have shown that over expression of Pgp is responsible for the ATP-dependent extrusion of a variety of compounds, including chemotherapeutic drugs, from cells (Abraham et al., 1993).
Over one-hundred ABC transporters have been identified in species ranging from Escherichia coli to humans (Higgins, 1995). For example, the bacteria Lactococcus lactis expresses an ABC transporter, LmrA, which mediates antibiotic resistance by extruding amphiphilic compounds from the inner leaflet of the cytoplasmic membrane (Van Veen et al., 1998). Furthermore, over-expression of LmrA can confer MDR in human lung fibroblasts and LmrA has similar molecular and biochemical properties to Pgp. This demonstrates that bacterial LmrA and Pgp are functionally interchangeable. Additionally, the plant Arabidopsis thaliana encodes an ATP transporter, AtPGP-1, which is a putative Pgp homolog (Dudler and Hertig, 1992). Similarly, the yeast Saccharomyces cerevisiae equivalent of Pgp, STS1 (Bissinger and Kucher, 1994) has been cloned and shown to confer multidrug resistance when over-expressed in yeast, as has the yeast Pdr5p (Kolacskowski et al., 1996). Taken together, these results suggest, that this type of multidrug resistance efflux pump is conserved from bacteria to humans.
While various theories of ABC transporter function have become popular, there is still no precise molecular-level description for the mechanism by which over-expression lowers intracellular accumulation of drugs, in particular how Pgp lowers intracellular accumulation of chemotherapeutic drugs. However, it has been shown that Pgp over-expression also changes plasma membrane electrical potential and intracellular pH which could potentially greatly affect the cellular flux of a large number of compounds to which Pgp confers resistance (Wadkins and Roepe, 1997). Also included in the ABC transporter superfamily are the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and the Sulfonyl Urea Receptor (SUR). CFTR and SUR are expressed in the lung epithelium and the β cells of the pancreas, respectively, as well as in other tissues. CFTR functions as a low conductance ATP and cyclic AMP-dependent Cl− channel that also appears to have additional important functions, such as modulation of epithelial NA+ regulation of outwardly rectified chloride channels (Wadkins and Roepe, 1997).
Mutations in the CFTR gene produce altered CFTR proteins with defects in CFTR function, leading to profound alterations in epithelial salt transport and altered mucous properties in cystic fibrosis patients that result in chronic lung infections associated with the disease. Id. SUR is triggered by sulfonyl urea drugs to depolarize pancreatic P cells that leads to Ca2+ influx, which stimulates fusion of insulin containing vesicles to the plasma membrane. Id. An ATP transporter hypothesis has been suggested for Pgp, CFTR and SUR which theorizes that these ABC transporters function as ATP transport channels (Abraham et al., 1993; Schweibert, 1995; Al-Awgati, 1995). The ATP channel hypothesis, however, has been viewed with skepticism. This is partly due to the inability to show the same results with preparations including purified and reconstituted CFTR, suggesting that the ATP conductance that was originally observed may have been mediated by another protein, not present in the purified system, that is influenced by CFTR (Wadkins and Roepe). There has been no such negative data reported with respect to the ATP charnel hypothesis for Pgp or SUR, but the controversy over CFTR has raised doubt for Pgp and SUR as well.
In support of the ATP channel hypothesis (Huang et al., 1992) have suggested that extracellular ATP leads to elevations in pH, and Weiner et al., (1986) have suggested that extracellular ATP may regulate Na−/H+ exchange in Ehrlich ascites tumor cells. It has also been observed that changes in Pgp levels affects pH and plasma membrane electrical potentials which could be connected to recent observations suggesting the involvement of ATP transport in MDR.
Additionally, Abraham et al., (1993) have reported that the addition of extracellular ATP to MDR cell lines confers sensitivity to drugs abolishing MDR. The data for this effect were not presented in the article and no further explanation was given for this phenomenon. Furthermore, there have been no subsequent publications addressing or explaining this effect.
Furthermore, Ujhazy et al., (1996) have shown that ecto-5′-nucleotidase is up-regulated in certain MDR cell lines. Ecto-5′-nucleotidase is the final enzyme in the extracellular pathway for salvage of adenosine from phosphorylated purines (Zimmerman, 1992). The proposed hypothesis for the involvement of ecto-5′-nucleotidase in drug resistance considers its role in the maintenance of intracellular ATP pools through the adenosine salvage pathway (Ujhazy et al., 1996). Ecto-5′-nucleotidase specifically acts in adenosine salvage pathways, converting AMP to adenosine which is more readily taken up by the cell and utilized as a precursor for ATP production. Therefore, ecto-5′-nucleotidase may be acting in certain MDR cell lines as a mechanism by which the cell circumvents the loss of ATP (due to up-regulated transport proteins which possibly form ATP transport channels) by creating higher levels of adenosine from which the cell can produce ATP. Correspondingly, 63% of MDR cell line variants tested expressed ecto-5′-nucleotidase. These observations suggested that a salvage mechanism for extracellular nucleotides may be another way by which certain MDR cells counterbalance their ATP losses from efflux induced by the over-expression of ABC transporters involved in MMR. Consistent with this hypothesis, inhibitors of ecto-5′-nucleotidase conferred sensitivity to certain drugs in MDR cell lines which over-express the ecto-5′-nucleotidase.
It is also interesting to note that yeast, which do not have an adenosine salvage pathway (Boyum and Guidotti, 1997), do contain a PGP-like gene called STS 1 (Bissinger and Kucher, 1994). Therefore, since the adenosine salvage pathway is unlikely to be involved in yeast multidrug resistance, other mechanisms are likely to exist.
Recent reports have confirmed the existence of ATP in the extracellular matrix (ECM) of both multicellular organisms and unicellular organisms (Sedaa et al., 1990; Boyum and Guidotti, 1997), respectively. However, no such reports are available which suggest the existence of ATP in the ECM of plants before the present invention. These reports have prompted further investigations of the fate of ATP outside the cell. One of the largest gradients in biological systems is that of ATP. It is a million-fold more concentrated inside the cell than outside. Phosphatases are enzymes with the ability to hydrolyze ATP and to a lesser extent, the beta phosphate of ADP (Plesner, 1995). Extracellular phosphatases are generally referred to as ectophosphatases A type of ectophosphatase is ecto-pyrase. Given reports that show the existence of extracellular ATP, one observation regarding ectoapyrase is that it hydrolyzes the extracellular ATP. In fact, work in animal systems has shown that apyrases hydrolyze ATP in the ECM as part of the adenosine salvage pathway conjointly with ecto-5′ ectonucleotidase (Che, 1992).
What has been lacking in the art are particular methods and compositions that allow modification of cellular ATP gradients to increase the uptake of cytotoxic agents by cells. It would be particularly useful to identify methods and compositions that result in increased uptake by cells of herbicides, antibiotics, fungicides, insecticides, chemotherapeutics and other active ingredients. This may result in increased efficacy in the use of such agents, as well as allow use of lower concentrations of such agents. This may provide cost, health and environmental benefits. This may also allow effective treatment of MDR cells, such as antibiotic-resistant bacteria or chemotherapy-resistant tumor cells.
SUMMARY OF THE INVENTION
In one aspect, the invention provides a cytotoxic composition comprising an ectophosphatase inhibitor and a cytotoxic agent set forth in Table 1. In one embodiment of the invention, the cytotoxic agent is selectively cytotoxic. In other embodiments, the cytotoxic composition may be further defined as a herbicidal composition and the cytotoxic agent a herbicide, may be further defined as an insecticidal composition and the cytotoxic agent an insecticide, may be further defined as a fungicidal composition and the cytotoxic agent a fungicide and/or may be further defined as an antibiotic composition and the cytotoxic agent an antibiotic. In an antibiotic composition, the antibiotic may be from a class selected from the group consisting of Beta-lactam, Semisynthetic penicillin, Clavulanic Acid, Monobactams, Carboxypenems, Aminoglycosides, Glycopeptides, Lincomycins, Macrolides, Polyenes, Rifamycins, Tetracyclines, Semisynthetic, tetracycline and Chloramphenicol. In certain embodiments of the invention, the ectophosphatase inhibitor may be selected from the group consisting of the compounds of formulae I-XX.
In another aspect, the invention provides a plant growth regulator composition comprising an ectophosphatase inhibitor and a plant growth regulator agent set forth in Table 1. In one embodiment of the invention, the ectophosphatase inhibitor is selected from the group consisting of the compounds of formulae I-XX.
In yet another aspect, the invention provides a chemotherapeutic composition comprising an ectophosphatase inhibitory compound and a chemotherapeutic agent. In one embodiment of the invention, the chemotherapeutic agent is a chemotherapeutic agent set forth in Table 3. In further embodiments of the invention, the ectophosphatase inhibitor is selected from the group consisting of the compounds of formulae I-XX.
In still yet another aspect, the invention provides a method of killing or inhibiting the growth of a plant, comprising contacting said plant with an effective amount of a herbicidal composition provided by the invention. The method may be carried out with potentially any plant, including a monocotyledonous plant or a dicotyledonous plant.
In still yet another aspect, the invention provides a method of killing or inhibiting the growth of a tumor cell, comprising contacting said tumor cell with an effective amount of a chemotherapeutic composition of the invention. In the method, contacting may comprise administering the composition to a patient in need thereof, wherein the patient comprises the tumor cell.
In still yet another aspect, the invention provides a method of killing or inhibiting the growth of a target cell, comprising contacting said cell with a composition formulated therefore. In certain embodiments of the invention, the cell may be a fungal cell, bacterial cell, or insect cell.
In still yet another aspect, the invention provides a method of increasing the effectiveness of a cytotoxic agent, comprising admixing said cytotoxic agent with an ectophosphatase inhibitor, wherein the cytotoxic agent is selected from the group set forth in Table 1. In certain embodiments of the invention, the cytotoxic agent may be further defined as a herbicide, insecticide, fungicide, and an antibiotic. Examples of antibiotics include those from the following classes: Beta-lactam, Semisynthetic penicillin, Clavulanic Acid, Monobactams, Carboxypenems, Aminoglycosides, Glycopeptides, Lincomycins, Macrolides, Polyenes, Rifamycins, Tetracyclines, Semisynthetic, tetracycline and Chloramphenicol. In one embodiment of the invention. In one embodiment of the invention, a cytotoxic agent is a chemotherapeutic agent, for example, selected from the group set forth in Table 3.
BRIEF DESCRIPTION OF THE DRAWINGS
The following drawings form part of the present specification and are included to further demonstrate certain aspects of the present invention. The invention may be better understood by reference to one or more of these drawings in combination with the detailed description of specific embodiments presented herein.
FIGS. 1A-1C Expression of apyrase in pea and in transgenic plants (FIG. 1A) Immunoblot analysis of subcellular fractions from etiolated pea plants. (FIG. 1B) Top, the total phosphate accumulated in the shoots of three independent transgenic plants. Bottom, a corresponding Immunoblot performed on protein from ECM of wild-type and transgenic plants. (FIG. 1C) Assay of phosphatase activity in the ECM fraction of OE1 and wild-type.
FIGS. 2A-C Transport of the products of ATP hydrolysis by transgenic plants overexpressing apyrase and by wild-type plants.
FIGS. 3A-D Conference of resistance to cycloheximide (FIG. 3A, B) and nigencin (FIG. 3C, D) in wild-type and ectophosphatase deficient yeast over-expressing the Arabidopsis plant ABC transporter, AtPGP-1.
FIGS. 4A-B-3 Conference of resistance to cycloheximide (FIG. 4A) and cytokinin (FIG. 4B-1-FIG. 4B-3) in Arabidopsis plants over-expressing either the ectophosphatase, apyrase, or the ABC transporter, AtPGP-1.
FIGS. 5A-B Graph showing the growth turbidity of YMR4 yeast over-expressing the Arabidopsis plant ABC transporter AtPGP-1 grown in cycloheximide (FIG. 5A) or nigericin (FIG. 5B).
FIG. 6 Graph showing germination rate of Arabidopsis plants grown in the presence of cycloheximide which over-express either the ectophosphatase, apyrase, or the ABC transporter AtPGP-1.
FIG. 7 Graph of steady-state levels of ATP in the extracellular fluid of wildtype yeast cells grown in the presence or absence of glucose and in the presence or absence of over-expression of the Arabidopsis plant ABC transporter, AtPGP-1.
FIG. 8 Graph showing that over-expression of Arabidopsis plant ABC transporter, AtPGP-1, in yeast can double the steady-state levels of ATP in the extracellular fluid.
FIG. 9 Graph showing that a yeast mutant, YMR4, that has a deficient ectophosphatase, accumulates ATP in the extracellular fluid and the over-expression of AtPGP-1 increases the accumulation of ATP.
FIG. 10 Graph showing results of a pulse-chase experiment in either wildtype yeast cells or a yeast mutant, YMR4, which is deficient in ectophosphatase activity, in the presence and absence of over-expression of Arabidopsis plant ABC transporter, AtPGP-1, demonstrating an early differential ATP efflux of cells over-expressing AtPGP-1.
FIG. 11 Graph of ATP levels on the surface of leaves of Arabidopsis plants over-expressing AtPGP-1 (MDR 1).
FIG. 12 Effects of phosphatase inhibitor in wild-type and AtPGP-1 (MDRI) overexpressing Arabidopsis plants.
FIG. 13 Growth effects of cycloheximide and extracellular ATP on wildtype and MDR1 overexpressing S. cerevisiae yeast cells which have either never seen cycloheximide or which have been previously selected in cycloheximide.
FIG. 14 Growth effects of cycloheximide, adenosine and phosphate on wildtype and AtPGP-1 overexpressing S. cerevisiae yeast cells.
DETAILED DESCRIPTION OF THE INVENTION
The present invention provides methods and compositions for modulating the sensitivity of cells to cytotoxic compounds and other active agents. In accordance with the invention, such modulation may be carried out by modifying cellular ATP gradients, for example, by contacting a plant, animal, yeast or bacterial cell with an ectophosphatase inhibitor contemporaneously with a cytotoxic agent or other active ingredient, or combinations thereof. As used herein, the term “ectophosphatase inhibitor” refers to a compound that has the ability to specifically inhibit ectophosphatase activity. A “cytotoxic agent” is a compound capable of selectively or non-selectively killing or inhibiting the growth of a cell, including antibiotics, fungicides, herbicides, insecticides and chemotherapeutic agents.
The efficacy of one or more cytotoxic agents may be increased in accordance with the invention by reducing the ATP gradient across biological membranes, which is effectuated through the modulation of an ectophosphatase either alone or together with an ABC transporter molecule. Modulation of resistance to a cytotoxic compound as described herein is useful, for example, in increasing the sensitivity of plants to herbicides; reducing drug resistance in tumor cells for improved chemotherapy applications; and reducing resistance to antibiotics, antifungal agents, insecticides and other cytotoxic agents for the treatment of infections and disease. Provided by the invention are specific combinations of ectophosphatase inhibitors and cytotoxic compounds or other active ingredients that may be used in these applications.
In accordance with certain embodiments of the invention, the manipulation of extracellular ATP levels to alter ATP gradient across biological membranes in cells by inhibition of ectophosphatases results in diminishing or removing the ATP gradient that may otherwise prevent access of cytotoxic agents to the cell. In some instances, access may be minimized by efflux of cytotoxic agents from the cell. This efflux is likely effectuated through the “piggy-back” efflux of drug molecules with ATP, a phenomenon known as symport.
In accordance with the invention, inhibitors of ectophosphatases may be administered contemporaneously with cytotoxic agents, including herbicides, antibiotics, fungicides, insecticides and other active ingredients, as well as chemotherapeutics. By “contemporaneously,” it is meant within sufficient temporal proximity that the increased sensitivity of a cell to the relevant cytotoxic agent may be achieved in combination with contacting the cell with the agent. In certain embodiments of the invention, ectophosphatase inhibitors are used as adjuvants with cytotoxic agents, that is, are admixed with one or more cytotoxic agents or other active ingredients.
It is therefore an, object of the present invention to provide inhibitors of ectophosphatases in physiological compositions for modulating cell growth and/or survival, including, but not limited to, MDR cells. Such physiological compositions may comprise a small molecule capable of inhibiting an ectophosphatase and a physiologically acceptable carrier or diluent together with a therapeutic agent. As used herein, the term “physiologically acceptable carrier or diluent” means any and all solvents, dispersion media, antibacterial and antifungal agents, microcapsules, liposomes, cationic lipid carriers, isotonic and absorption delaying agents and the like which are not incompatible with the ectophosphatase inhibitors. The use of such media and agents for physiologically active substances is well known in the art. Supplementary active ingredients may also be incorporated into the compositions.
In certain embodiments, only an endogenous ectophosphatase is inhibited. In particular embodiments of the invention, the ectophosphatase is human apyrase. In other embodiments, the ectophosphatase is a plant, bacterial, fungal or yeast ectophosphatase.
The inhibition of ectophosphatases is useful in increasing sensitivity to cytotoxic agents and/or reduction of drug resistance in cells. In one embodiment of the invention, the inhibition of ectophosphatases results in a loss of resistance to a cytotoxic agent. In another embodiment of the invention, administration of such inhibitory molecules is in conjunction with the administration of chemotherapeutic agents in tumor cells.
Using high throughput screens, ectophosphatase inhibitors may be isolated, for example, by screening a small molecule library (e.g. a combinatorial library) for inhibitory activity to ectophosphatase (e.g. apyrase activity). Once ectophosphatase inhibitory molecules are isolated from such a screen, the inhibitors may be further tested for their ability to specifically inhibit the ATPase activity of the ectophosphatase.
Exemplary ectophosphatase inhibitory molecules for use with the current invention are preferably chemically stable and physiologically active including, but not limited to, the compounds of formulae I-XX.
Preliminary pharmacophore studies revealed that the small molecules represented by Formulae I through XX fall into five classes of compounds (sulfanamides, guanidines, aminothiazoles, thioketones and benzamides). Most of these chemical classes are found in other physiologically-active compounds, including those having pharmaceutical and therapeutic use. For example, sulfanimides are widely used as antibiotics. Additionally, studies for the isolation of small molecules capable of reversing MDR have described molecules belonging to two of the classes of molecules of the present invention (Medina et al. 1998; Dhamant et al., 1992). The molecules described by Medina et al. have been shown to affect MDR and the mode of action of the molecules is believed to involve tubulin interactions. The thiazine derivatives described by Dhamant et al. reverse the resistance in tumor cells to vincristine.
The ectophosphatase inhibitory molecules are useful in increasing the activities of various agents by increasing the availability of the agents to cells. In certain embodiments of the invention, this may comprise reversing multidrug resistance (MDR) in an organism. In other embodiments, this may be achieved with a cell that does not exhibit MDR. Such cells may or may not comprise an up-regulated ectophosphatase
MDR reversal and/or increasing of sensitivity to a cytotoxic agent in cells may be shown by growing the cells in the presence of relevant drugs and in the presence and absence of the inhibitor. Cells which cannot grow in the presence of a drug in the presence of an ectophosphatase inhibitor, have a reversal in MDR and/or increase in sensitivity to the agent.
The ectophosphatase inhibitory compositions of the present invention are useful in reversing drug resistance in mammalian cell lines grown in the presence of a drug (e.g. a chemotherapeutic agent). Analysis of sensitivity to a chemotherapeutic composition in mammalian cells may be shown, for example, by using the fluorescent compound calcein-AM. Esterases present in cells cleave the aceto-methoxy ester (AM) from the calcein-AM and liberate calcein. Calcein is a fluorescent compound which is excitable by the 488 nm laser of a FACS Caliber flow cytometer (Becton Dickenson, Franklin Lakes, N.J.), while the uncleaved calcein-AM is not excitable. Wild type cells incubated in the presence of calcein-AM show a high level of fluorescence while MDR state cells, which efflux the calcein-AM faster than the cellular esterases can cleave it, do not show a high level of fluorescence. The mammalian cells can be tested for the reversal of MDR with ectophosphatase inhibitors by the amount of calcein fluorescence detected in the cells.
Specificity of ectophosphatase inhibitors may be tested with the screening assays described herein. Inhibitors can be tested for their ability to inhibit acid phosphatases, alkaline phosphatases, myosin phosphatases and the luciferase ATPase. The assays may be performed using techniques known in the art.
In one embodiment of the invention, the ectophosphatase is an apyrase and the ectophosphatase inhibitor is a molecule selected from among molecules represented by the Formulae I through XX. In another embodiment, the ectophosphatase is apyrase and the ectophosphatase inhibitor is a molecule selected from among molecules represented by the Formulae I through V.
In a further embodiment of the invention, the ectophosphatase is apyrase and the ectophosphatase inhibitor is a molecule represented by Formula XX. Formula XX is suramin or 8,8′[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl imino]]bis-1,3,5-naphthalenetrisulfonic acid. Suramin has been reported as a potent non-competitive inhibitor of ectoapyrase activity associated with the plasma membrane of cholinergic nerve terminal of Torpedo mannorata electric organs (arti et al., 1996).
It is contemplated that in certain embodiments of the invention an ectophosphatase inhibitor may inhibit an ectophosphatase active on the outer membrane of an organelle of a eukaryotic cell. In this manner, contacting the cell with the ectophosphatase inhibitor may be used to decrease the ATP gradient across the organelle and thereby facilitate uptake of a biologically active agent by the organelle.
I. Formulations
Ectophosphatase inhibitor compositions, which may be acidic or basic in nature, can form a wide variety of salts with various inorganic and organic bases or acids, respectively. These salts may be physiologically acceptable for in vivo administration in mammals, including humans, as well as formulations for ex vivo applications, including agricultural use. Salts of acidic compounds are readily prepared by treating the acidic compound with an appropriate molar quantity of the chosen inorganic or organic base in an aqueous or suitable organic solvent and then evaporating the solvent to obtain the salt. Salts of basic compounds can be obtained similarly by treatment with the desired inorganic or organic acid and subsequent solvent evaporation and isolation. The skilled artisan can produce salts of ectophosphatase inhibitors using techniques known in the art.
The skilled artisan readily can determine the amount of the ectophosphatase inhibitor that is required to inhibit ectophosphatase by measuring ATPase activity in the presence and absence of varying amounts of the inhibitor. Phosphatase activity can be determined by assessing the dephosphorylation of ATP and liberation of phosphate as described herein. Additionally, parameters may be measured that are known to be associated with ectophosphatase activity to determine whether the molecule has ectophosphatase inhibitory activity. For example, ectophosphatase inhibitory activity may be measured in cells (e.g., yeast, plant, bacterial, mammalian, and tumor cell lines) by assessing the loss of resistance to drugs. Furthermore, the ectophosphatase inhibitory molecules of the present invention may be tested for specific inhibitory activity to ectophosphatases versus general phosphatases or for specific inhibitory activity for a particular ectophosphatase activity (e.g., apyrase).
The present invention also provides physiologically acceptable compositions comprising an ectophosphatase inhibitor, a cytotoxic agent or other active ingredient and a physiologically acceptable carrier or diluent. In certain embodiments of the invention, as set forth in detail below, compositions are provided comprising one or more ectophosphatase inhibitor and one or more plant growth regulator, herbicide, fungicide, insecticide, antibiotic, chemotherapeutic agent or other active compound. In a further embodiment of the invention, the ectophosphatase is selected from the compounds of formulae I-XX in the appropriate carriers, diluents or other active ingredients.
The use of physiologically acceptable carriers or diluents is well known in the art. The techniques of preparation of pharmaceutical compositions are generally well known in the art as exemplified by Remington's Pharmaceutical Sciences, 16th Ed. Mack Publishing Company, 1980, which reference is specifically incorporated herein by reference in its entirety. Formulations of the present invention may be stable under the conditions of manufacture and storage and must be preserved against contamination by microorganisms.
The physiological forms of the compositions of the invention suitable for administration include sterile aqueous solutions or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersions. Typical carriers include a solvent or dispersion medium containing, for example, water buffered aqueous solutions (i.e., biocompatible buffers), ethanol, polyols such as glycerol, propylene glycol, polyethylene glycol, suitable mixtures thereof, surfactants, and vegetable oils. Isotonic agents such as sugars or sodium chloride may be incorporated into the subject compositions.
Pharmaceutical compositions in accordance with the invention may be used by themselves or in combination with other forms active ingredients or therapeutics. One embodiment of the invention provides formulations for parenteral administration, e.g., formulated for injection via the intravenous, intramuscular, sub-cutaneous or other such routes. Typically, such compositions can be prepared as injectables, either as liquid solutions or suspensions; solid forms suitable for using to prepare solutions or suspensions upon the addition of a liquid prior to injection also can be prepared; and the preparations also can be emulsified.
Solutions of the active compounds as free base or pharmacologically acceptable salts can be prepared in water suitably mixed with a surfactant, such as hydroxypropylcellulose. Dispersions also can be prepared in glycerol, liquid polyethylene glycols, and mixtures thereof and in oils. Under ordinary conditions of storage and use, these preparations contain a preservative to prevent the growth of microorganisms.
The pharmaceutical forms suitable for injectable use include sterile aqueous solutions or dispersions; formulations including sesame oil, peanut oil or aqueous propylene glycol; and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersions. In all cases, the form must be sterile and must be fluid to the extent that easy syringability exists. It must be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms, such as bacteria and fungi.
Carriers used also can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), suitable mixtures thereof, and vegetable oils. The proper fluidity can be maintained, for example, by the use of a coating, such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants. The prevention of the action of microorganisms can be brought about by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, sorbic acid, thimerosal, and the like. In many cases, it will be preferable to include isotonic agents, for example, sugars or sodium chloride. Prolonged absorption of the injectable compositions can be brought about by the use in the compositions of agents delaying absorption, for example, aluminum monostearate and gelatin.
Sterile injectable solutions are prepared by incorporating the active compounds in the required amount in the appropriate solvent with various of the other ingredients enumerated above, as required, followed by filtered sterilization. Generally, dispersions are prepared by incorporating the various sterilized active ingredients into a sterile vehicle which contains the basic dispersion medium and the required other ingredients from those enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, the preferred methods of preparation are vacuum-drying and freeze-drying techniques which yield a powder of the active ingredient plus any additional desired ingredient from a previously sterile-filtered solution thereof.
Other modes of administration can also find use with the invention. For instance, pharmaceutical compounds may be formulated in suppositories and, in some cases, aerosol and intranasal compositions. For suppositories, the vehicle composition will include traditional binders and carriers such as polyalkylene glycols or triglycerides. Such suppositories may be formed from mixtures containing the active ingredient in the range of about 0.5% to about 10% (w/w), preferably about 1% to about 2%.
Ectophosphatase inhibitors will commonly comprise from less than 1% to about 10% w/v of a composition with an active ingredient, including about 1%, 3%, 5%, &% and about 10%. Greater or lesser amounts of the ectophosphatase inhibitors may similarly be used. Desired concentrations may readily be determined by serial preparation and assay of compositions comprising varying amounts of the selected ectophosphatase inhibitor compound. For example, in the case of herbicidal compositions, a series of test compositions comprising from about 0.1% to about 25% w/v of an ectophosphatase inhibitor together with a test herbicide may be analyzed by leaf painting and comparison of the results. Safety, efficacy, cost and other concerns may each be taken into account in selecting the desired concentrations. Alternatively, pharmaceutical compositions may be analyzed using in vitro or in vivo models.
Oral compositions may be prepared in the form of solutions, suspensions, tablets, pills, capsules, sustained release formulations, or powders. These compositions can be administered, for example, by swallowing or inhaling. Where a pharmaceutical composition is to be inhaled, the composition will preferably comprise an aerosol. Exemplary procedures for the preparation of aqueous aerosols may be found in U.S. Pat. No. 5,049,388, the disclosure of which is specifically incorporated herein by reference in its entirety. Preparation of dry aerosol preparations are described in, for example, U.S. Pat. No. 5,607,915, the disclosure of which is specifically incorporated herein by reference in its entirety.
Also useful is the administration of the compounds described herein directly in transdermal formulations with permeation enhancers such as DMSO. These compositions can similarly include any other suitable carriers, excipients or diluents. Other topical formulations can be administered to treat certain disease indications. For example, intranasal formulations may be prepared which include vehicles that neither cause irritation to the nasal mucosa nor significantly disturb ciliary function. Diluents such as water, aqueous saline or other known substances can be employed with the subject invention. The nasal formulations also may contain preservatives such as, but not limited to, chlorobutanol and benzalkonium chloride. A surfactant may be present to enhance absorption of the subject compounds by the nasal mucosa.
Upon formulation, solutions may be administered in a manner compatible with the dosage formulation and in such amount as is therapeutically effective. The formulation of choice can be accomplished using a variety of excipients including, for example, pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, sodium saccharin cellulose, magnesium carbonate, and the like. Typically, pharmaceutical compositions will contain from less than 1% to about 95% of the active ingredient, preferably about 10% to about 50%. Preferably, between about 10 mg/kg patient body weight per day and about 25 mg/kg patient body weight per day will be administered to a patient, including a human patient. The frequency of administration will be determined by the care given based on patient responsiveness. Other effective dosages can be readily determined by one of ordinary skill in the art through routine trials establishing dose response curves.
Regardless of the mode of administration, suitable pharmaceutical compositions in accordance with the invention will generally include an amount of active ingredient admixed with an acceptable pharmaceutical diluent or excipient, such as a sterile aqueous solution, to give a range of final concentrations, depending on the intended use. The techniques of preparation are generally well known in the art as exemplified by Remington's Pharmaceutical Sciences, 16th Ed. Mack Publishing Company, 1980, which reference is specifically incorporated herein by reference in its entirety. It should be appreciated that endotoxin contamination should be kept minimally at a safe level, for example, less that 0.5 ng/mg protein. Moreover, for human administration, preparations should meet sterility, pyrogenicity, general safety and purity standards as required by FDA Office of Biological Standards.
The therapeutically effective doses are readily determinable using an animal model. For example, experimental animals exhibiting a target infection or other ailment are frequently used to optimize appropriate therapeutic doses prior to translating to a clinical environment. Such models are known to be very reliable in predicting effective therapies. In certain embodiments, it may be desirable to provide a continuous supply of therapeutic compositions to the patient. For intravenous or intraarterial routes, this is accomplished by drip system. For topical applications, repeated application would be employed. For various approaches, delayed release formulations could be used that provided limited but constant amounts of the therapeutic agent over and extended period of time. For internal application, continuous perfusion of the region of interest may be preferred. This could be accomplished by catheterization, post-operatively in some cases, followed by continuous administration of the therapeutic agent. The time period for perfusion would be selected by the clinician for the particular patient and situation, but times could range from about 1-2 hours, to 2-6 hours, to about 6-10 hours, to about 10-24 hours, to about 1-2 days, to about 1-2 weeks or longer. Generally, the dose of the therapeutic composition via continuous perfusion will be equivalent to that given by single or multiple injections, adjusted for the period of time over which the injections are administered. It is believed that higher doses may be achieved via perfusion, however.
Therapeutic kits comprising the compositions described herein are also provided by the invention. Such kits will generally contain, in suitable container means, a pharmaceutically or agriculturally acceptable formulation of the active ingredient. The kits also may contain other pharmaceutically acceptable formulations, such as an antiinfective agent, including an insecticide, antifungal or antibacterial, as well as a herbicide.
The kits may have a single container means that contains the active ingredient, with or without any additional components, or they may have distinct container means for each desired agent. When the components of the kit are provided in one or more liquid solutions, the liquid solution is an aqueous solution, with a sterile aqueous solution being particularly preferred. However, the components of the kit may be provided as dried powder(s). When reagents or components are provided as a dry powder, the powder can be reconstituted by the addition of a suitable solvent. It is envisioned that the solvent also may be provided in another container means. The container means of the kit will generally include at least one vial, test tube, flask, bottle, syringe or other container means, into which the active compound, and any other desired agent, may be placed and, preferably, suitably aliquoted. Where additional components are included, the kit will also generally contain a second vial or other container into which these are placed, enabling the administration of separated designed doses. The kits also may comprise a second/third container means for containing a sterile, pharmaceutically acceptable buffer or other diluent.
The kits also may contain a means by which to administer the compositions to an animal or patient, e.g., one or more needles or syringes, or even an eye dropper, pipette, or other such like apparatus, from which the formulation may be injected into the animal or applied to a afflicted area of the body. The kits of the present invention will also typically include a means for containing the vials, or such like, and other component, in close confinement for commercial sale, such as, e.g., injection or blow-molded plastic containers into which the desired vials and other apparatus are placed and retained.
The invention also provides compositions formulated for agricultural use. Examples of such formulations include herbicidal, fungicidal and plant growth regulator compositions. Specific formulations for plant application are known to those of skill in the art and are described, for example, in U.S. Pat. No. 6,242,382, the disclosure of which is specifically incorporated herein by reference in its entirety.
Examples of ingredients that may be included in a composition of the invention formulated for application to plants include surfactants, solid or liquid carriers, solvents and binders. Examples of suitable surfactants that may be used for application to plants include the alkali metal, alkaline earth metal or ammonium salts of aromatic sulfonic acids, e.g., ligno-, phenol-, naphthalene- and dibutylnaphthalenesulfonic acid, and of fatty acids of arylsulfonates, of alkyl ethers, of lauryl ethers, of fatty alcohol sulfates and of fatty alcohol glycol ether sulfates, condensates of sulfonated naphthalene and its derivatives with formaldehyde, condensates of naphthalene or of the naphthalenesulfonic acids with phenol and formaldehyde, condensates of phenol or phenolsulfonic acid with formaldehyde, condensates of phenol with formaldehyde and sodium sulfite, polyoxyethylene octylphenyl ether, ethoxylated isooctyl-, octyl- or nonylphenol, tributylphenyl polyglycol ether, alkylaryl polyether alcohols, isotridecyl alcohol, ethoxylated castor oil, ethoxylated triarylphenols, salts of phosphated triarylphenolethoxylates, lauryl alcohol polyglycol ether acetate, sorbitol esters, lignin-sulfite waste liquors or methylcellulose, or mixtures of these. Common practice in the case of surfactant use is to include about 0.5 to 25% by weight, based on the total weight of the solid mixture.
Compositions for application to plants may be solid or liquid. Where solid compositions are used, it may be desired to include one or more carrier materials with the active compound. Examples of carriers include mineral earths such as silicas, silica gels, silicates, talc, kaolin, attaclay, limestone, chalk, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground synthetic materials, fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, thiourea and urea, products of vegetable origin such as cereal meals, tree bark meal, wood meal and nutshell meal, cellulose powders, attapulgites, montmorillonites, mica, vermiculites, synthetic silicas and synthetic calcium silicates, or mixtures of these.
For liquid solutions, water-soluble compounds or salts may be included, such as sodium sulfate, potassium sulfate, sodium chloride, potassium chloride, sodium acetate, ammonium hydrogen sulfate, ammonium chloride, ammonium acetate, ammonium formate, ammonium oxalate, ammonium carbonate, ammonium hydrogen carbonate, ammonium thiosulfate, ammonium hydrogen diphosphate, ammonium dihydrogen monophosphate, ammonium sodium hydrogen phosphate, ammonium thiocyanate, ammonium sulfamate or ammonium carbamate.
Other exemplary components in compositions of the invention include binders such as polyvinylpyrrolidone, polyvinyl alcohol, partially hydrolyzed polyvinyl acetate, carboxymethylcellulose, starch, vinylpyrrolidone/vinyl acetate copolymers and polyvinyl acetate, or mixtures of these; lubricants such as magnesium stearate, sodium stearate, talc or polyethylene glycol, or mixtures of these; antifoams such as silicone emulsions, long-chain alcohols, phosphoric esters, acetylene diols, fatty acids or organofluorine compounds, and complexing agents such as: salts of ethylenediaminetetraacetic acid (EDTA), salts of trinitrilotriacetic acid or salts of polyphosphoric acids, or mixtures of these.
In certain embodiments of the invention, compositions are provided with herbicidal activity which comprise one or more ectophosphatase inhibitor(s) and a herbicide selected from the group consisting of pendimethalin, dicamba, 2,4-D, glufosinate, bentazon, trifluralin, oryzalin, S-metolachlor, nicosulfuron, MSMA, Epic™ and Balance™. In one embodiment of the invention, the ectophosphatase inhibitor is selected from the group of the compounds of formulae I-XX. In certain other embodiments of the invention, compositions with fungicidal activity are provided which comprise one or more ectophosphatase inhibitor(s) in combination with metalaxyl, tebuconazole, propiconazole, chlorothalonil and/or fluconazole.
Non-limiting examples of combinations of cytotoxic agents and ectophosphatase inhibitors for use in accordance with the invention include: fluconazole with compound(s) of formula II, IX, XIV, XVI, XV, X and/or XII; formula I and/or II with pendimethalin, dicamba, 2,4-D, bentazon, trifluralin, flufenacet/isoxaflutole or isoxaflutole; glufosinate with formula II; oryzalin with formula I; nicosulflron with formula II; MSMA with formula XVIII; S-metolachlor with formula VI and/or X; metribuzin with formula I, II and/or X; diuron with formula VI; metalaxyl with formula X; chlorothalonil with formula II, X, IX, XI, XVI; propiconazole with formula I, X, XIV and/or XVI; mancozeb with formula I, VI and/or X; captan with formula XIV and/or XVI; tebuconazole with formula I and/or X; imidacloprid with formula II, X, XVIII, XVI and/or XV; and fertilizers such as Nitrogen, Phosphate, Potash—12:12:12 with formula I and/or II.
Also envisioned for use with the invention are compositions comprising combinations of ectophosphatase inhibitors and cytotoxic agents or other active ingredients, including a herbicide, insecticide, antibiotic, fungicide, plant growth regulator and/or hormone. Such combinations may provide enhanced activity of the active ingredient relative to the use of a single ectophosphatase inhibitor. Non-limiting examples of such combinations of ectophosphatase inhibitors include combinations of two, three, four or more ectophosphatase inhibitors selected from formulas I, II, VI, X, XV, XIV, XVI, XVI, XV, and XVIII. Included for illustrative purposes are the following combinations: I and II; I, II and X; XIV and XVI; XVIII and XVI; XVI, XVI and XV; VI and X; II and X; and I and XVIII.
Specifically contemplated by the inventors are compositions comprising an ectophosphatase inhibitor and an active ingredient set forth in Table 1.
TABLE 1
|
|
Cytotoxic agents and other active ingredients
U.S. EPA PCCA Chem
Chemical NameCAS NumberCodeCodeUse TypeChemical Class
|
Bis(2-ethylhexyl) phthalate117-81-73E+05NA 11N/AAlkyl Phthalate
Butyl benzyl phthalate85-68-7NA 1413080N/AAlkyl Phthalate
Chlorthal-dimethyl1861-32-178701179HerbicideAlkyl Phthalate
Di-n-octyl phthalate117-84-0NA 303223N/AAlkyl Phthalate
Dibutyl phthalate84-74-228001199InsectAlkyl Phthalate
Repellent
Diethyl phthalate84-66-21E+053326N/AAlkyl Phthalate
Diisodecyl phthalateNA 1037NA 1322513N/AAlkyl Phthalate
Dimethyl phthalate131-11-328002232InsectAlkyl Phthalate
Repellent
Dioctyl terephthalateNA 724NA 1332528N/AAlkyl Phthalate
Diphenyl phthalate84-62-817001NA 147N/AAlkyl Phthalate
Isooctyl phthalate27554-26-3NA 4832262N/AAlkyl Phthalate
n-Butyl phthalate84-74-2280013081InsecticideAlkyl Phthalate
Poly glyceryl phthalate ester ofNA 327NA 6083331Adjuvant,Alkyl Phthalate
coconut oil fatty acidSoap/Surfactant
1,3-Dimethyl-1,1,3,3-22232-20-834601NA 303N/ABis-Carbamate
disiloxanetetrol-1,3-
bis(dimethylthiocarbamate)
2,3(and 3,4)-Dichlorobenzyl62046-37-13E+05NA 136InsecticideN-Methyl Carbamate
methylcarbamates
2,4-Dimethyl-1,3-dithiolane-2-26419-73-84E+05NA 143InsecticideN-Methyl Carbamate
carboxaldehyde O-
(methylcarbamoyl)oxime
2-(4,5-Dimethyl-1,3-dioxolan-########4E+05NA 145InsecticideN-Methyl Carbamate
2-yl)phenyl-N-
methylcarbamate
2-chloro-4,5-xylyl N-hydroxy-14357-82-52E+05NA 117InsecticideN-Methyl Carbamate
N-methylcarbamate
2-cyclopentylphenyl3282-00-63E+05NA 132InsecticideN-Methyl Carbamate
methylcarbamate
2-Hydroxyphenyl10309-97-42E+05NA 118InsecticideN-Methyl Carbamate
methylcarbamate
3,4-Dichlorobenzyl2328-31-63E+05NA 136InsecticideN-Methyl Carbamate
methylcarbamate
3,5-Diisopropylphenyl330-64-34E+05NA 142InsecticideN-Methyl Carbamate
methylcarbamate
3-hydroxycarbofuran16655-82-62E+054074BreakdownN-Methyl Carbamate
product
3-iodo-2-propynyl butyl55406-53-61E+051938Fungicide,Other Carbamate
carbamateWood
Preservative
3-ketocarbofuran16709-30-1NA 176NA 164BreakdownN-Methyl Carbamate
product
4-17702-57-74E+05NA 142InsecticideN-Methyl Carbamate
(((Dimethylamino)methylene)amino)-
m-tolyl
methylcarbamate
4-(Methylamino)-3,5-xylyl10389-50-12E+05NA 118InsecticideN-Methyl Carbamate
methylcarbamate
4-(Methylformamido)-3,5-10233-94-02E+05NA 118InsecticideN-Methyl Carbamate
xylyl methylcarbamate
4-(Methylthio)-m-tolyl3566-00-56E+05NA 157InsecticideN-Methyl Carbamate
methylcarbamate
4-Amino-3,5-xylyl831-76-52E+05NA 117InsecticideN-Methyl Carbamate
methylcarbamate
5,6,7,8-Tetrahydro-1-naphthyl1136-84-14E+05NA 148InsecticideN-Methyl Carbamate
methylcarbamate
6-(and 2)-chloro-3,4-xylyl8063-85-238701NA 322InsecticideN-Methyl Carbamate
methylcarbamate
6-Methyl-2-propyl-4-2532-49-26E+05NA 157N/AOther Carbamate
pyrimidinyl dimethylcarbamate
Alanycarb83130-01-2NA 175NA 47InsecticideOther Carbamate
Aldicarb116-06-398301575Insecticide,N-Methyl Carbamate
Nematicide
Aldicarb sulfoxide1646-87-31E+052361BreakdownN-Methyl Carbamate
product
Aldoxycarb1646-88-41E+052265BreakdownN-Methyl Carbamate
product
Allyxycarb6392-46-73E+05NA 133InsecticideN-Methyl Carbamate
Aminocarb2032-59-9444012435InsecticideN-Methyl Carbamate
Asulam3337-71-11E+055076HerbicideOther Carbamate
Asulam, sodium salt2302-17-21E+051746HerbicideOther Carbamate
Bendiocarb22781-23-31E+051924InsecticideN-Methyl Carbamate
Benfuracarb82560-54-11E+05NA 48InsecticideOther Carbamate
Bufencarb2282-34-05930291InsecticideN-Methyl Carbamate
Bufencarb8065-36-959303NA 485InsecticideN-Methyl Carbamate
Bufencarb, component of (with672-04-859301NA 484InsecticideN-Methyl Carbamate
059302)
Butacarb2655-19-83E+05NA 135InsecticideN-Methyl Carbamate
Butocarboxim34681-10-2NA 175NA 49InsecticideN-Methyl Carbamate
Butoxycarboxim34681-23-71E+052201InsecticideN-Methyl Carbamate
Butylate2008-41-541405565HerbicideThiocarbamate
Calcium5895-18-114501NA 139MicrobiocideDithiocarbamate
ethylenebis(dithiocarbamate)
Carbanolate671-04-52E+05NA 124InsecticideN-Methyl Carbamate
Carbaryl63-25-256801105Insecticide,N-Methyl Carbamate
Plant Growth
Regulator,
Nematicide
Carbofuran1563-66-290601106Insecticide,N-Methyl Carbamate
Nematicide
Carbosulfan55285-14-8906022182InsecticideN-Methyl Carbamate
Chlorbufam1967-16-46E+05NA 157HerbicideOther Carbamate
Chlorprocarb23121-99-533E+05NA 136HerbicideOther Carbamate
Chlorpropham101-21-318301141Herbicide,Other Carbamate
Plant Growth
Regulator
Cloethocarb51487-69-51E+05NA 100Insecticide,N-Methyl Carbamate
Molluscicide
Cufraneb11096-18-7NA 181NA 180FungicideDithiocarbamate
Cycloate1134-23-241301516HerbicideThiocarbamate
Desmedipham13684-56-51E+051748HerbicideBis-Carbamate
Diammonium########14502NA 140MicrobiocideDithiocarbamate
ethylenebis(dithiocarbamate)
Dichlormate1966-58-13E+05690HerbicideN-Methyl Carbamate
Diethofencarb87130-20-9NA 184NA 183FungicideOther Carbamate
Dimepiperate61432-55-1NA 186NA 185HerbicideThiocarbamate
Dimetan122-15-61E+05NA 112InsecticideOther Carbamate
Dimethyl (4-methyl-1,3-51543-98-71E+05NA 888FungicideBis-Carbamate
phenylenebis(iminocarbonyl-
1H-benzimidazole-1,2-
diyl))biscarbamate
Dimetilan644-64-490101NA 844InsecticideOther Carbamate
Dioxacarb6988-21-24E+054067InsecticideN-Methyl Carbamate
EPTC759-94-441401264HerbicideThiocarbamate
Esprocarb85785-20-2NA 203NA 202HerbicideThiocarbamate
Ethiofencarb29973-13-51E+05NA 50InsecticideN-Methyl Carbamate
Ethiolate2941-55-11E+051793HerbicideThiocarbamate
Fenethacarb30087-47-93E+05NA 141InsecticideN-Methyl Carbamate
Fenobucarb3766-81-2NA 176NA 51InsecticideN-Methyl Carbamate
Fenothiocarb62850-32-2NA 188NA 187InsecticideThiocarbamate
Fenoxycarb79127-80-31E+052283Insecticide,Other Carbamate
Insect Growth
Regulator
Fenoxycarb72490-01-8NA 228NA 228Insecticide,Other Carbamate
Insect Growth
Regulator
Ferbam14484-64-134801288FungicideDithiocarbamate
Ferric nitroso dimethyl83542-83-05E+05NA 149MicrobiocideDithiocarbamate
dithiocarbamate
Formetanate22259-30-95E+05NA 150InsecticideN-Methyl Carbamate
Formetanate hydrochloride23422-53-997301111InsecticideN-Methyl Carbamate
Furathiocarb65907-30-4NA 176NA 52InsecticideThiocarbamate
Isolan119-38-05E+05NA 155InsecticideOther Carbamate
Isopolinate3134-70-1NA 232NA 232HerbicideThiocarbamate
Isoprocarb2631-40-55E+05NA 53InsecticideN-Methyl Carbamate
Karbutilate4849-32-597401691HerbicideOther Carbamate
m-Cumenyl methylcarbamate64-00-647801NA 414InsecticideN-Methyl Carbamate
Mancopper53988-93-5NA 181NA 180FungicideDithiocarbamate
Mancozeb########14504211FungicideDithiocarbamate,
Inorganic-Zinc
Maneb12427-38-214505369FungicideDithiocarbamate
Maneb and nickel sulfate8005-46-76E+05NA 158FungicideDithiocarbamate,
hexahydrate (014505 + 050505)Inorganic-Nickel
Manganous15339-36-334802NA 304FungicideDithiocarbamate
dimethyldithiocarbamate
Mecarbinizid27386-64-76E+05NA 157N/AOther Carbamate
Mercuric dimethyl15415-64-234808709MicrobiocideInorganic-Mercury,
dithiocarbamateHeavy metal,
Dithiocarbamate
Metam sodium, dihydrate137-42-839003NA 163Fumigant,Dithiocarbamate
Fungicide,
Microbiocide,
Algaecide,
Nematicide
Metam-sodium6734-80-139003616Fumigant,Dithiocarbamate
Herbicide,
Fungicide,
Microbiocide,
Algaecide,
Nematicide
Methasulfocarb66952-49-6NA 202NA 201Fungicide,Thiocarbamate
Plant Growth
Regulator
Methiobencarb18357-78-3NA 232NA 232HerbicideThiocarbamate
Methiocarb2032-65-71E+05375Insecticide,N-Methyl Carbamate
Molluscicide
Methiocarb sulfone2179-25-12E+054077BreakdownN-Methyl Carbamate
product
Methiocarb sulfoxide########2E+054078BreakdownN-Methyl Carbamate
product
Methomyl16752-77-590301383Insecticide,N-Methyl Carbamate
Breakdown
product
Metiram9006-42-214601493FungicideDithiocarbamate,
Inorganic-Zinc
Metolcarb1129-41-5NA 202NA 201InsecticideN-Methyl Carbamate
Mexacarbate315-18-444201623InsecticideN-Methyl Carbamate
Mobam1079-33-090401NA 848InsecticideN-Methyl Carbamate
Molinate2212-67-141402449HerbicideThiocarbamate
Molinate sulfoxideNA 1052NA 1564080BreakdownThiocarbamate
product
Morpholinomethyl31848-11-06E+05NA 158MicrobiocideDithiocarbamate
dimethyldithiocarbamate
Nabam142-59-614503417Fungicide,Dithiocarbamate
Herbicide
Nitrilacarb29672-19-32E+05NA 129InsecticideOther Carbamate
o-(2-Propynyloxy)phenyl3279-46-73E+05NA 138InsecticideN-Methyl Carbamate
methylcarbamate
Orbencarb34622-58-7NA 189NA 188HerbicideThiocarbamate
Oxamyl23135-22-01E+051910Insecticide,N-Methyl Carbamate
Nematicide
Pebulate1114-71-241403590HerbicideThiocarbamate
Phenisopham57375-63-0NA 209NA 208HerbicideBis-Carbamate
Phenmedipham13684-63-498701675HerbicideBis-Carbamate
Phenmedipham-ethyl13684-44-14E+05NA 149HerbicideBis-Carbamate
Phenylmercuric32407-99-166008NA 555Microbiocide,Organomercury,
dimethyldithiocarbamateFungicideDithiocarbamate,
Heavy metal
Pirimicarb23103-98-21E+051875InsecticideN-Methyl Carbamate
Pirimicarb sulfoneNA 1050NA 1554090BreakdownN-Methyl Carbamate
product
Pirimicarb sulfoxideNA 1049NA 1554091BreakdownN-Methyl Carbamate
product
Potassium ammonium22221-14-314507NA 141MicrobiocideDithiocarbamate
ethylenebis(dithiocarbamate)
Potassium asulam14089-43-11E+05NA 893HerbicideOther Carbamate
Potassium dimethyl dithio128-03-0348031934MicrobiocideDithiocarbamate
carbamate
Potassium N-hydroxymethyl-51026-28-91E+051824N/ADithiocarbamate
N-methyldithio carbamate
Potassium N-methyldithio137-41-739002970Fumigant,Dithiocarbamate
carbamateFungicide,
Microbiocide,
Algaecide,
Nematicide
Promacyl34264-24-9NA 209NA 209InsecticideN-Methyl Carbamate
Promecarb2631-37-03E+054092InsecticideN-Methyl Carbamate
Propamocarb24579-73-51E+052147FungicideOther Carbamate
Propamocarb hydrochloride25606-41-11E+054022FungicideOther Carbamate
Propham122-42-947601339Herbicide,Other Carbamate
Plant Growth
Regulator
Propineb12071-83-95E+05NA 155Fungicide,Dithiocarbamate,
MicrobiocideInorganic-Zinc
Propoxur114-26-14780262InsecticideN-Methyl Carbamate
Propoxur, other relatedNA 1073NA 16190062InsecticideN-Methyl Carbamate
Prosulfocarb52888-80-9NA 185NA 184HerbicideThiocarbamate
Prothiocarb19622-08-3NA 183NA 182FungicideThiocarbamate
Prothiocarb hydrochloride19622-19-6NA 200NA 199FungicideThiocarbamate
Pyributicarb88678-67-5NA 229NA 229HerbicideThiocarbamate
Pyrolan87-47-86E+05NA 157InsecticideOther Carbamate
S-tert-Butyl2212-63-72E+05NA 128HerbicideThiocarbamate
dipropylthiocarbamate
Sodium dimethyl dithio128-04-134804548FungicideDithiocarbamate
carbamate
Sulfallate95-06-739001115HerbicideDithiocarbamate
Swep1918-18-9846014098N/AOther Carbamate
Terbutol########3880151HerbicideN-Methyl Carbamate
Tert-butyl dimethyl trithio3304-97-0348071383RodentDithiocarbamate
peroxycarbamateRepellent
Tert-NA 1130NA 16691383N/ADithiocarbamate
butyldimethyltrithioperoxycarbamate,
other related
Thiobencarb28249-77-61E+051933HerbicideThiocarbamate
Thiobencarb sulfoxideNA 1042NA 1392937BreakdownThiocarbamate
product
Thiocarboxime25171-63-56E+05NA 156N/AN-Methyl Carbamate
Thiodicarb59669-26-01E+052202Molluscicide,Thiocarbamate
Insecticide
Thiofanox39196-18-41E+052938InsecticideN-Methyl Carbamate
Thiram137-26-879801589FungicideDithiocarbamate
Thiram and NAD and IBA and75497-92-656011NA 463Fungicide,Dithiocarbamate
2-methyl-1-Plant Growth
naphthaleneacetamide and 2-Regulator
methyl-1-naphthaleneacetic
acid
Tiocarbazil36756-79-31E+05NA 911HerbicideThiocarbamate
Triallate2303-17-57880249HerbicideThiocarbamate
Tricopper dichloride7076-63-35E+05NA 152MicrobiocideDithiocarbamate,
dimethyldithiocarbamateInorganic-Copper
Trimethacarb12407-86-21E+052962Insecticide,N-Methyl Carbamate
Molluscicide,
Dog and Cat
Repellent
Trimethacarb, (2,3,5)-2655-15-41E+05NA 882Insecticide,N-Methyl Carbamate
component ofMolluscicide
Trimethacarb, (3,4,5)-2686-99-91E+05NA 881Insecticide,N-Methyl Carbamate
component ofMolluscicide
Vernolate1929-77-7414041987HerbicideThiocarbamate
XMC2655-14-3NA 176NA 54InsecticideN-Methyl Carbamate
Xylylcarb########NA 176NA 55InsecticideN-Methyl Carbamate
Zineb12122-67-714506627FungicideDithiocarbamate,
Inorganic-Zinc
Zineb-ethylene thiuramNA 1465NA 217NA 216FungicideDithiocarbamate,
disulfide adductInorganic-Zinc
Ziram137-30-434805629Fungicide,Dithiocarbamate,
Microbiocide,Inorganic-Zinc
Dog and Cat
Repellent
Ziram, cyclohexylamine16509-79-8348061328Dog and CatDithiocarbamate,
complexRepellent,Inorganic-Zinc
Fungicide
Acetamiprid135410-20-799050NA 864InsecticideChloro-nicotinyl
Imidacloprid105827-78-9#####3849InsecticideChloro-nicotinyl
Imidacloprid138261-41-3#####NA 111InsecticideChloro-nicotinyl
Thiacloprid111988-49-9NA 201NA 201InsecticideChloro-nicotinyl
Halofenozide112226-61-6#####5019InsecticideDiacylhydrazine
Methoxyfenozide161050-58-4#####NA 983InsecticideDiacylhydrazine
Tebufenozide112410-23-8#####3957InsecticideDiacylhydrazine
Bacillus thuringiensis Cry1FNA 14866481NA 220InsecticideGE Crop
protein and the genetic material
necessary for its production
(plasmid insert PHI8999) in
corn pla
Bacillus thuringiensis Cry1AbNA 14876430NA 220InsecticideGE Crop
Delta-Endotoxin and the
Genetic Material Necessary for
Its Production in Corn [MON
810]
Bacillus thuringiensis delta68038-71-1NA 1603954InsecticideGE Crop
endotoxin produced in corn
Bacillus thuringiensis subsp.NA 12266463NA 170InsecticideGE Crop
Kurstaki CryIA (c) delta-
endotoxin and the genetic
material necessary for its
production in corn
Bacillus thuringiensis subsp.68038-71-164445048InsecticideGE Crop
Kurstaki, delta-endotoxin as
produced in corn by an HD-1
gene, and its controlling
sequences and
Bacillus thuringiensis subsp.NA 12336466NA 171InsecticideGE Crop
Tolworthi Cry9C protein and
the genetic material necessary
for its production (pRVA9909)
in corn p
Bacillus thuringiensisNA 12376432NA 171InsecticideGE Crop
subspecies Tenebrionis delta
endotoxin as produced in
potato by Cry IIIA gene and its
controlling sequenc
Bacillus thuringiensis var.NA 148064023554InsecticideGE Crop
Kurstaki protein in cottonseed
Bacillus thuringiensis, subsp.68038-71-164613986InsecticideGE Crop
Kurstaki, strain HD-1, delta-
endotoxin as produced in corn
by a Cry 1A(b) gene and its
controlling
HD-1 Protein as encoded byNA 12736408NA 173InsecticideGE Crop
Bacillus thuringiensis subsp.
kurstaki gene and produced in
corn
Plant pesticide BacillusNA 12856458NA 174InsecticideGE Crop
thuringiensis Cry1A(b) delta-
endotoxin and the genetic
material necessary for its
production (plasmid V
Potato leafroll virus (PLRV)NA 12956469NA 175FungicideGE Crop
replicase protein as produced in
potato plants
1,1,1-trichloroethane71-55-681201138SolventHalogenated organic
1,1,2-trichloro-1,2,2-trifluoro-76-13-1NA 9722960SolventHalogenated organic
ethane
1,1,2-trichloroethane79-00-5812031425SolventHalogenated organic
1,2,3,4-Tetrachlorobenzene634-66-261101NA 494N/AHalogenated organic
1,2,4-trichlorobenzene120-82-181101600N/AHalogenated organic
1,2-dichloropropane78-87-5290022501Fumigant,Halogenated organic
Nematicide
1,2-Dichloropropane mixt. with########29004NA 215Fumigant,Halogenated organic
1,3-dichloropropene andNematicide
methyl isothiocyanate
1,2-dichloropropane, 1,3-NA 102229002185Fumigant,Halogenated organic
dichloropropene and related C3Nematicide
compounds
1,3-Dichloro-1-propene, mixt.8003-19-829003NA 214Fumigant,Halogenated organic
with 1,2-dichloropropaneNematicide
1,3-dichloropropene542-75-629001573Fumigant,Halogenated organic
Nematicide
1-chloro-1,1-difluoro ethane75-68-3NA 4233103SolventHalogenated organic
1-chlorobutane109-69-3NA 4251151SolventHalogenated organic
3-chloro-2-methyl propene563-47-3NA 4222463N/AHalogenated organic
Bis(2,2-dichloroethyl)ether1191-17-929502NA 217N/AHalogenated organic
Bromoethane74-96-4NA 1312427N/AHalogenated organic
Carbon tetrachloride56-23-516501109Solvent,Halogenated organic
Fumigant
Carbon tetrachloride with EDB53908-27-316503NA 146Fumigant,Halogenated organic
& EDCNematicide
Carbon tetrachloride with EDC########16502NA 145Fumigant,Halogenated organic
Nematicide
Carbon tetrafluoride75-73-0NA 1133099PropellantHalogenated organic
Chloro difluoro methane75-45-6153104Propellant,Halogenated organic
Fumigant,
Insecticide
Chlorodibromomethane124-48-1NA 4262462N/AHalogenated organic
Chloroform67-66-320701133Solvent,Halogenated organic
Fumigant
DBCP96-12-811301183Fumigant,Halogenated organic
Nematicide
DBCP, other relatedNA 1079NA 16190183Fumigant,Halogenated organic
Nematicide
Dichloroethylene, 1,1-75-35-46E+05NA 13ImpurityHalogenated organic
Dichlorofluoromethane75-43-4NA 3481815PropellantHalogenated organic
Difluoro diphenyl475-26-332001NA 293N/AHalogenated organic
trichloroethane
Ethane, 1,1,1,2-tetrafluoro-811-97-21E+05NA 873N/AHalogenated organic
Ethyl chloride75-00-3NA 1143198N/AHalogenated organic
Ethylene chlorobromide107-04-0420012557N/AHalogenated organic
Ethylene dibromide106-93-442002271Fumigant,Halogenated organic
Nematicide
Ethylene dichloride107-06-242003274Fumigant,Halogenated organic
Insecticide
Freon 1175-69-4131460Propellant,Halogenated organic
Fumigant,
Insecticide
Freon 1275-71-8141459Propellant,Halogenated organic
Fumigant,
Insecticide
Halazone80-13-777201316N/AHalogenated organic
Hexachloroacetone116-16-543701320HerbicideHalogenated organic
Hexachloroacetone, otherNA 1090NA 16290320HerbicideHalogenated organic
related
Hexachloroethane67-72-145201NA 22N/AHalogenated organic
Hydrofluorocarbon 152ANA 617NA 1122599PropellantHalogenated organic
Methyl bromide74-83-953201385Fumigant,Halogenated organic
Insecticide,
Herbicide,
Nematicide
Methyl chloride74-87-3532022677N/AHalogenated organic
Methyl iodide74-88-4NA 177NA 165Fumigant,Halogenated organic
Nematicide
Methylene chloride75-09-242004388Solvent, DogHalogenated organic
and Cat
Repellent
Ortho-dichlorobenzene95-50-159401578InsecticideHalogenated organic
Ortho-dichlorobenzene, otherNA 1116NA 16590683InsecticideHalogenated organic
related
Para-dichlorobenzene106-46-761501455Insecticide,Halogenated organic
Insect
Repellent,
Rodenticide,
Fungicide
Pentachloroethane76-01-76E+05NA 159N/AHalogenated organic
Propargyl bromide106-96-768701NA 608Fumigant,Halogenated organic
Nematicide
Tetrachloroethane79-34-5786013559Solvent,Halogenated organic
Fumigant
Tetrachloroethylene127-18-4785011174SolventHalogenated organic
Tetraiodo ethylene513-92-846908582N/AHalogenated organic
trans-1,3-Dichloropropene10061-02-6NA 227NA 227FumigantHalogenated organic
Trichloro ethylene79-01-681202595N/AHalogenated organic
Trichlorobenzene87-61-6NA 9711619N/AHalogenated organic
Trichlorofluoromethane75-69-4133482Propellant,Halogenated organic
Fumigant,
Insecticide
Trichloromethane67-66-3207011758Solvent,Halogenated organic
Fumigant
2,3(and 3,4)-Dichlorobenzyl62046-37-1#####NA 136InsecticideN-Methyl Carbamate
methylcarbamates
2,4-Dimethyl-1,3-dithiolane-2-26419-73-8#####NA 143InsecticideN-Methyl Carbamate
carboxaldehyde O-
(methylcarbamoyl)oxime
2-(4,5-Dimethyl-1,3-dioxolan-1905930#####NA 145InsecticideN-Methyl Carbamate
2-yl)phenyl-N-
methylcarbamate
2-chloro-4,5-xylyl N-hydroxy-14357-82-5#####NA 117InsecticideN-Methyl Carbamate
N-methylcarbamate
2-cyclopentylphenyl3282-00-6#####NA 132InsecticideN-Methyl Carbamate
methylcarbamate
2-Hydroxyphenyl10309-97-4#####NA 118InsecticideN-Methyl Carbamate
methylcarbamate
3,4-Dichlorobenzyl2328-31-6#####NA 136InsecticideN-Methyl Carbamate
methylcarbamate
3,5-Diisopropylphenyl330-64-3#####NA 142InsecticideN-Methyl Carbamate
methylcarbamate
3-hydroxycarbofuran16655-82-6#####4074BreakdownN-Methyl Carbamate
product
3-ketocarbofuran16709-30-1NA 176NA 164BreakdownN-Methyl Carbamate
product
4-17702-57-7#####NA 142InsecticideN-Methyl Carbamate
(((Dimethylamino)methylene)amino)-
m-tolyl
methylcarbamate
4-(Methylamino)-3,5-xylyl10389-50-1#####NA 118InsecticideN-Methyl Carbamate
methylcarbamate
4-(Methylformamido)-3,5-10233-94-0#####NA 118InsecticideN-Methyl Carbamate
xylyl methylcarbamate
4-(Methylthio)-m-tolyl3566-00-5#####NA 157InsecticideN-Methyl Carbamate
methylcarbamate
4-Amino-3,5-xylyl831-76-5#####NA 117InsecticideN-Methyl Carbamate
methylcarbamate
5,6,7,8-Tetrahydro-1-naphthyl1136-84-1#####NA 148InsecticideN-Methyl Carbamate
methylcarbamate
6-(and 2)-chloro-3,4-xylyl8063-85-238701NA 322InsecticideN-Methyl Carbamate
methylcarbamate
Aldicarb116-06-398301575Insecticide,N-Methyl Carbamate
Nematicide
Aldicarb sulfoxide1646-87-3#####2361BreakdownN-Methyl Carbamate
product
Aldoxycarb1646-88-4#####2265BreakdownN-Methyl Carbamate
product
Allyxycarb6392-46-7#####NA 133InsecticideN-Methyl Carbamate
Aminocarb2032-59-9444012435InsecticideN-Methyl Carbamate
Bendiocarb22781-23-3#####1924InsecticideN-Methyl Carbamate
Bufencarb2282-34-05930291InsecticideN-Methyl Carbamate
Bufencarb8065-36-959303NA 485InsecticideN-Methyl Carbamate
Bufencarb, component of (with672-04-859301NA 484InsecticideN-Methyl Carbamate
059302)
Butacarb2655-19-8#####NA 135InsecticideN-Methyl Carbamate
Butocarboxim34681-10-2NA 175NA 49InsecticideN-Methyl Carbamate
Butoxycarboxim34681-23-7#####2201InsecticideN-Methyl Carbamate
Carbanolate671-04-5#####NA 124InsecticideN-Methyl Carbamate
Carbaryl63-25-256801105Insecticide,N-Methyl Carbamate
Plant Growth
Regulator,
Nematicide
Carbofuran1563-66-290601106Insecticide,N-Methyl Carbamate
Nematicide
Carbosulfan55285-14-8906022182InsecticideN-Methyl Carbamate
Cloethocarb51487-69-5#####NA 100Insecticide,N-Methyl Carbamate
Molluscicide
Dichlormate1966-58-1#####690HerbicideN-Methyl Carbamate
Dioxacarb6988-21-2#####4067InsecticideN-Methyl Carbamate
Ethiofencarb29973-13-5#####NA 50InsecticideN-Methyl Carbamate
Fenethacarb30087-47-9#####NA 141InsecticideN-Methyl Carbamate
Fenobucarb3766-81-2NA 176NA 51InsecticideN-Methyl Carbamate
Formetanate22259-30-9#####NA 150InsecticideN-Methyl Carbamate
Formetanate hydrochloride23422-53-997301111InsecticideN-Methyl Carbamate
Isoprocarb2631-40-5#####NA 53InsecticideN-Methyl Carbamate
m-Cumenyl methylcarbamate64-00-647801NA 414InsecticideN-Methyl Carbamate
Methiocarb2032-65-7#####375Insecticide,N-Methyl Carbamate
Molluscicide
Methiocarb sulfone2179-25-1#####4077BreakdownN-Methyl Carbamate
product
Methiocarb sulfoxide267266#####4078BreakdownN-Methyl Carbamate
product
Methomyl16752-77-590301383Insecticide,N-Methyl Carbamate
Breakdown
product
Metolcarb1129-41-5NA 202NA 201InsecticideN-Methyl Carbamate
Mexacarbate315-18-444201623InsecticideN-Methyl Carbamate
Mobam1079-33-090401NA 848InsecticideN-Methyl Carbamate
o-(2-Propynyloxy)phenyl3279-46-7#####NA 138InsecticideN-Methyl Carbamate
methylcarbamate
Oxamyl23135-22-0#####1910Insecticide,N-Methyl Carbamate
Nematicide
Pirimicarb23103-98-2#####1875InsecticideN-Methyl Carbamate
Pirimicarb sulfoneNA 1050NA 1554090BreakdownN-Methyl Carbamate
product
Pirimicarb sulfoxideNA 1049NA 1554091BreakdownN-Methyl Carbamate
product
Promacyl34264-24-9NA 209NA 209InsecticideN-Methyl Carbamate
Promecarb2631-37-0#####4092InsecticideN-Methyl Carbamate
Propoxur114-26-14780262InsecticideN-Methyl Carbamate
Propoxur, other relatedNA 1073NA 16190062InsecticideN-Methyl Carbamate
Terbutol54193880151HerbicideN-Methyl Carbamate
Thiocarboxime25171-63-5#####NA 156N/AN-Methyl Carbamate
Thiofanox39196-18-4#####2938InsecticideN-Methyl Carbamate
Trimethacarb12407-86-2#####2962Insecticide,N-Methyl Carbamate
Molluscicide,
Dog and Cat
Repellent
Trimethacarb, (2,3,5)-2655-15-4#####NA 882Insecticide,N-Methyl Carbamate
component ofMolluscicide
Trimethacarb, (3,4,5)-2686-99-9#####NA 881Insecticide,N-Methyl Carbamate
component ofMolluscicide
XMC2655-14-3NA 176NA 54InsecticideN-Methyl Carbamate
Xylylcarb190572NA 176NA 55InsecticideN-Methyl Carbamate
Aldrin309-00-2451019InsecticideOrganochlorine
Aldrin, other relatedNA 1069NA 16090009InsecticideOrganochlorine
alpha-BHC319-84-6NA 200767InsecticideOrganochlorine
Arochlor (composition12767-79-217803NA 161N/AOrganochlorine
unspecified, PCBs and/or
PCTs)
Aroclor1336-36-3178015003N/AOrganochlorine
Bandane8029-29-62030154InsecticideOrganochlorine
BHC (other than gammaNA 1092NA 16290359InsecticideOrganochlorine
isomer)
BHC, beta isomer319-85-7NA 175NA 46InsecticideOrganochlorine
Chlordane57-74-958201130InsecticideOrganochlorine
Chlordane, other relatedNA 1075NA 16190130InsecticideOrganochlorine
Chlordane, technical12789-03-658202NA 477InsecticideOrganochlorine
Chlordecone143-50-027701347InsecticideOrganochlorine
Chlorendic Acid115-28-6NA 228NA 228N/AOrganochlorine
DDD72-54-8291013002InsecticideOrganochlorine
DDD6088-31-3NA 415184BreakdownOrganochlorine
product
DDD, other relatedNA 1080NA 16190184BreakdownOrganochlorine
product
DDE72-55-9NA 1292092BreakdownOrganochlorine
product
DDT50-29-329201186InsecticideOrganochlorine
Dicofol115-32-210501346InsecticideOrganochlorine
Dieldrin60-57-145001210Insecticide,Organochlorine
Breakdown
product
Dieldrin, other relatedNA 1085NA 16290210InsecticideOrganochlorine
Dienochlor2227-17-027501468InsecticideOrganochlorine
Dioxin (2,3,7,8-TCDD)1746-01-6#####4068ImpurityOrganochlorine
Dioxin (other than 2,3,7,8-NA 1319NA 177NA 176ImpurityOrganochlorine
TCDD)
Endosulfan115-29-779401259InsecticideOrganochlorine
Endosulfan I (alpha)959-98-879402NA 771InsecticideOrganochlorine
Endosulfan II (beta)33213-65-9794034046InsecticideOrganochlorine
Endosulfan sulfate1031-07-8794044047BreakdownOrganochlorine
product
Endrin72-20-841601262Insecticide,Organochlorine
Avicide
Endrin aldehyde7421-93-4NA 1564069BreakdownOrganochlorine
product
Endrin ketone53494-70-5416015029BreakdownOrganochlorine
product
Endrin, other relatedNA 1086NA 16290262InsecticideOrganochlorine
Heptachlor76-44-844801317InsecticideOrganochlorine
Heptachlor epoxide1024-57-3448014073BreakdownOrganochlorine
product
Heptachlor, other relatedNA 1089NA 16290317InsecticideOrganochlorine
Hexachloro dibenzo-p-dioxin34465-46-8#####2587ImpurityOrganochlorine
Hexachlorobenzene118-74-161001321Microbiocide,Organochlorine
Fungicide,
Insecticide
Hexachlorocyclohexane608-73-18901NA 20InsecticideOrganochlorine
Hexachlorocyclopentadiene77-47-427502NA 21InsecticideOrganochlorine
Hexachlorodibenzofuran (as55684-94-1#####NA 161ImpurityOrganochlorine
impurity)
Isodrin465-73-6NA 208NA 207InsecticideOrganochlorine
Kelevan4234-79-1NA 208NA 208InsecticideOrganochlorine
Lindane58-89-99001359Insecticide,Organochlorine
Rodenticide
Methoxychlor72-43-534001384InsecticideOrganochlorine
Methoxychlor, other relatedNA 1093NA 16290384InsecticideOrganochlorine
Mirex2385-85-539201402InsecticideOrganochlorine
Nonachlor3734-49-4448025448InsecticideOrganochlorine
Oxychlordane27304-13-8NA 177NA 177BreakdownOrganochlorine
product
Oxychlordane, mix of isomers26880-48-8NA 177NA 177BreakdownOrganochlorine
product
Strobane8001-50-120401553InsecticideOrganochlorine
Toxaphene8001-35-280501594InsecticideOrganochlorine
trans-Nonachlor39765-80-5NA 177NA 177InsecticideOrganochlorine
(E)-Mevinphos298-01-115802NA 143InsecticideOrganophosphorus
(Z)-Mevinphos338-45-415803NA 144InsecticideOrganophosphorus
2,5-dichloro-alpha-2701-86-2#####NA 116InsecticideOrganophosphorus
(chloromethylene)benzyl
diethyl phosphate
2,5-dichloro-alpha-5723-62-6#####NA 116InsecticideOrganophosphorus
(dichloromethylene)benzyl
diethyl phosphate
Acephate30560-19-1#####1685InsecticideOrganophosphorus
Acethion919-54-0#####NA 139InsecticideOrganophosphorus
Acetoxon2425-25-4#####NA 139Insecticide,Organophosphorus
Breakdown
product
Akton1757-18-2849011421InsecticideOrganophosphorus
Akton, other relatedNA 1131NA 16691421InsecticideOrganophosphorus
alpha,alpha-Dithiol bis(O,O-2782-70-9#####NA 150N/AOrganophosphorus
dimethyl
phosphorodithioate)toluene
Amidithion919-76-659601NA 487InsecticideOrganophosphorus
Amiton78-53-557302NA 473InsecticideOrganophosphorus
Amiton oxalate3734-97-257301NA 472InsecticideOrganophosphorus
Anilofos64249-01-0NA 202NA 201InsecticideOrganophosphorus
Athidathion19691-80-6#####NA 141InsecticideOrganophosphorus
Azamethiphos35575-96-3#####NA 111InsecticideOrganophosphorus
Azethion72348-92-6#####NA 139InsecticideOrganophosphorus
Azinphos-ethyl2642-71-9580024053InsecticideOrganophosphorus
Azinphos-methyl86-50-058001314InsecticideOrganophosphorus
Azinphos-methyl oxygenNA 1057NA 1574054BreakdownOrganophosphorus
analogproduct
Azothoate5834-96-8#####NA 118InsecticideOrganophosphorus
Bensulide741-58-2980170HerbicideOrganophosphorus
Bomyl122-10-18420177InsecticideOrganophosphorus
Bromophos2104-96-38706NA 106InsecticideOrganophosphorus
Bromophos-ethyl4824-78-6#####NA 122InsecticideOrganophosphorus
Butamifos36335-67-8NA 202NA 201HerbicideOrganophosphorus
Butathiofos90338-20-8#####2433InsecticideOrganophosphorus
Butonate126-22-735701255N/AOrganophosphorus
Cadusafos95465-99-9#####NA 14InsecticideOrganophosphorus
Carbophenothion786-19-658102110InsecticideOrganophosphorus
Chlorethoxyphos54593-83-8#####5106InsecticideOrganophosphorus
Chlorfenvinphos470-90-684101306InsecticideOrganophosphorus
Chlormephos24934-91-6#####NA 136InsecticideOrganophosphorus
Chlorphoxim14816-20-7NA 207NA 206InsecticideOrganophosphorus
Chlorprazophos36145-08-1#####NA 136InsecticideOrganophosphorus
Chlorpyrifos2921-88-259101253Insecticide,Organophosphorus
Nematicide
Chlorpyrifos oxygen analog5598-15-2591015034Insecticide,Organophosphorus
Breakdown
product
Chlorpyrifos-methyl5598-13-0591022468InsecticideOrganophosphorus
Chlorthion500-28-734501NA 300InsecticideOrganophosphorus
Chlorthiophos21923-23-9#####2469InsecticideOrganophosphorus
Chlorthiophos60238-56-4#####NA 919InsecticideOrganophosphorus
Chlorthiophos II77503-29-8#####NA 918InsecticideOrganophosphorus
Chlorthiophos III77503-28-7#####NA 917InsecticideOrganophosphorus
cis-Azodrin919-44-858902NA 482InsecticideOrganophosphorus
cis-Methocrotophos69632-93-5#####NA 143InsecticideOrganophosphorus
Coumaphos56-72-436501165InsecticideOrganophosphorus
Coumaphos, other relatedNA 1077NA 16190165InsecticideOrganophosphorus
Coumithioate572-48-5#####NA 141InsecticideOrganophosphorus
Crotoxyphos7700-17-658801140InsecticideOrganophosphorus
Crotoxyphos, other relatedNA 1076NA 16190140InsecticideOrganophosphorus
Cyanofenphos13067-93-1#####NA 131InsecticideOrganophosphorus
Cyanophos2636-26-2#####NA 131InsecticideOrganophosphorus
Cyanthoate3734-95-0#####NA 131InsecticideOrganophosphorus
Cythioate115-93-559501NA 486InsecticideOrganophosphorus
DDVP62-73-784001187Insecticide,Organophosphorus
Breakdown
product
DDVP, other relatedNA 10818400190187InsecticideOrganophosphorus
Demephion-O682-80-4#####NA 143Insecticide,Organophosphorus
Breakdown
product
Demephion-S2587-90-8#####NA 143InsecticideOrganophosphorus
Demeton8065-48-357601566Insecticide,Organophosphorus
Nematicide
Demeton-O298-03-357602NA 474InsecticideOrganophosphorus
Demeton-O-methyl867-27-658703NA 480InsecticideOrganophosphorus
Demeton-S126-75-057603NA 475InsecticideOrganophosphorus
Demeton-S-methyl919-86-8NA 200NA 200InsecticideOrganophosphorus
Demeton-S-methyl (mixture)8022-00-2587014063InsecticideOrganophosphorus
Demeton-S-methyl sulfone17040-19-6NA 183NA 182BreakdownOrganophosphorus
product,
Insecticide
Dequest 2010 phosphonateNA 579NA 1052496N/AOrganophosphorus
Dialifor10311-84-9#####1799InsecticideOrganophosphorus
Dialifor, other relatedNA 1138NA 16791799InsecticideOrganophosphorus
Diamidafos1754-58-1#####NA 879Insecticide,Organophosphorus
Nematicide
Diazinon333-41-557801198InsecticideOrganophosphorus
Diazoxon962-58-3NA 1564064BreakdownOrganophosphorus
product
Dichlofenthion97-17-628601614Insecticide,Organophosphorus
Nematicide
Dicrotophos141-66-23520172InsecticideOrganophosphorus
Dimethoate60-51-535001216InsecticideOrganophosphorus
Dimethoate-ethyl116-01-8#####NA 147InsecticideOrganophosphorus
Dioxabenzofos3811-49-2#####NA 112InsecticideOrganophosphorus
Dioxathion78-34-237801192InsecticideOrganophosphorus
Dioxathion, other relatedNA 1083NA 16190192InsecticideOrganophosphorus
Diphenprofos59010-86-5#####NA 920InsecticideOrganophosphorus
Disulfoton298-04-432501230Insecticide,Organophosphorus
Nematicide
Disulfoton sulfone216746#####NA 140InsecticideOrganophosphorus
Disulfoton sulfoxide216777#####NA 140BreakdownOrganophosphorus
product
Ditalimfos5131-24-8#####NA 891FungicideOrganophosphorus
DMCP3309-87-3#####NA 119InsecticideOrganophosphorus
Edifenphos17109-49-8#####1964InsecticideOrganophosphorus
Endothion319315#####NA 146InsecticideOrganophosphorus
EPBP3792-59-4#####NA 155InsecticideOrganophosphorus
EPN2104-64-541801263InsecticideOrganophosphorus
Ethephon16672-87-0998011626Plant GrowthOrganophosphorus
Regulator
Ethion563-12-258401268InsecticideOrganophosphorus
Ethion, O-analog17356-42-258402NA 478BreakdownOrganophosphorus
product
Ethoprop13194-48-441101404Insecticide,Organophosphorus
Nematicide
Ethyl (2-5840-95-9#####NA 149InsecticideOrganophosphorus
mercaptoethyl)carbamate, S-
ester of O,O-dimethyl
phosphorodithioate
Ethyl hydrogen 1-21921-96-0#####NA 148N/AOrganophosphorus
propylphosphonate
Etrimfos38260-54-7#####NA 147InsecticideOrganophosphorus
Famphur52-85-759901282InsecticideOrganophosphorus
Famphur, O-analog960-25-859902NA 491BreakdownOrganophosphorus
product
Fenamiphos22224-92-6#####1857Insecticide,Organophosphorus
Nematicide
Fenamiphos sulfone31972-44-8NA 1564070BreakdownOrganophosphorus
product
Fenamiphos sulfoxide31972-43-7NA 1564071BreakdownOrganophosphorus
product
Fenitrothion122-14-5#####2520InsecticideOrganophosphorus
Fensulfothion115-90-232701181Insecticide,Organophosphorus
Nematicide
Fenthion55-38-95330163Insecticide,Organophosphorus
Avicide
Fenthion oxon3254-63-5#####NA 143BreakdownOrganophosphorus
product
Fonofos944-22-941701254InsecticideOrganophosphorus
Formothion2540-82-1#####NA 143InsecticideOrganophosphorus
Fosmethilan83733-82-8NA 208NA 207InsecticideOrganophosphorus
Fospirate5598-52-7#####1856InsecticideOrganophosphorus
Fosthiazate98886-44-3#####NA 109N/AOrganophosphorus
Fosthietan21548-32-3#####NA 928Fumigant,Organophosphorus
Nematicide
Heptenophos23560-59-0#####NA 122InsecticideOrganophosphorus
Hexylthiofos41495-67-4#####NA 132InsecticideOrganophosphorus
Iodofenfos18181-70-9#####NA 138InsecticideOrganophosphorus
Iprobenfos26087-47-8NA 203NA 202FungicideOrganophosphorus
IPSP1432970NA 208NA 207InsecticideOrganophosphorus
Isazophos42509-80-8#####2282InsecticideOrganophosphorus
Isazophos-methyl42509-83-1#####NA 136InsecticideOrganophosphorus
Isocarbophos24353-61-5#####2414InsecticideOrganophosphorus
Isochlorthion2463-84-534502NA 301InsecticideOrganophosphorus
Isofephos25311-71-1#####2194InsecticideOrganophosphorus
Isothioate36614-38-7NA 208NA 207InsecticideOrganophosphorus
Isoxathion18854-01-857802NA 476InsecticideOrganophosphorus
Leptophos21609-90-5#####1676InsecticideOrganophosphorus
Leptophos, other relatedNA 1135NA 16791676InsecticideOrganophosphorus
Lythidathion2669-32-1#####NA 147InsecticideOrganophosphorus
MalaoxonNA 1054NA 1564076BreakdownOrganophosphorus
product
Malathion121-75-557701367InsecticideOrganophosphorus
Mecarbam2595-54-2#####NA 140InsecticideOrganophosphorus
Mecarphon29173-31-7#####NA 156InsecticideOrganophosphorus
Menazon78-57-9#####NA 134N/AOrganophosphorus
Mephosfolan950-10-7#####NA 131InsecticideOrganophosphorus
Merphos150-50-574901293Defoliant, PlantOrganophosphorus
Growth
Regulator
Merphos, other relatedNA 1088NA 16290293Defoliant, PlantOrganophosphorus
Growth
Regulator
Merpofos3568-56-7#####NA 129N/AOrganophosphorus
Methacrifos62610-77-9NA 189NA 188InsecticideOrganophosphorus
Methamidophos10265-92-6#####1697Insecticide,Organophosphorus
Breakdown
product
Methidathion950-37-8#####1689InsecticideOrganophosphorus
Methidathion OANA 1065#####5040InsecticideOrganophosphorus
Methyl paraoxon950-35-6535024083BreakdownOrganophosphorus
product
Methyl parathion298-00-053501394Insecticide,Organophosphorus
Nematicide
Methyl parathion, other relatedNA 1094NA 16290394Insecticide,Organophosphorus
Nematicide
Methyl phenkapton3735-23-7#####NA 142N/AOrganophosphorus
Methyl trithion953-17-3581013531InsecticideOrganophosphorus
Methyl-carbofenthionNA 843NA 1574057InsecticideOrganophosphorus
Mevinphos7786-34-715801480InsecticideOrganophosphorus
Mevinphos (stereochemistry26718-65-0NA 200NA 200InsecticideOrganophosphorus
unspecified)
Mevinphos, other relatedNA 1103NA 16390480InsecticideOrganophosphorus
Miral42509-80-8#####2689InsecticideOrganophosphorus
Monocrotophos6923-22-45890152InsecticideOrganophosphorus
Morphothion144-41-2#####NA 143InsecticideOrganophosphorus
Naled300-76-534401418InsecticideOrganophosphorus
Naphthalophos1491-41-4#####NA 117InsecticideOrganophosphorus
O,O,S-Trimethyl2953-29-9#####NA 161ImpurityOrganophosphorus
phosphorodithiate (as impurity)
O,O-diethyl O-2668-92-0#####NA 138InsecticideOrganophosphorus
naphthaloximido
phosphorothioate
O,O-diethyl phosphoro226542NA 3382508InsecticideOrganophosphorus
chloridothionate
O,O-Diethyl S-(4,6-dimethyl-333-40-4#####NA 140InsecticideOrganophosphorus
2-pyrimidinyl)
phosphorodithioate
O,O-diethyl-O-phenyl32345-29-2NA 3372507InsecticideOrganophosphorus
phosphorothioate
O,O-dimethyl S-(2-2674-91-158704NA 481InsecticideOrganophosphorus
(ethylsulfinyl)-1-methylethyl)
phosphorothioate
O-(2-chloro-4-nitrophenyl) O-328-04-1#####NA 137N/AOrganophosphorus
isopropyl
ethylphosphonothioate
O-(4-Nitrophenyl) O-phenyl2665-30-7#####NA 158N/AOrganophosphorus
methylphosphonothioate
O-ethyl O-(4-2703-13-1#####NA 117N/AOrganophosphorus
(methylthio)phenyl)
methylphosphonothioate
O-Ethyl S-(4-methylphenyl)333-43-7#####NA 149N/AOrganophosphorus
ethylphosphonodithioate
O-Methyl 2-nitro-4-tolyl36001-88-4#####NA 157N/AOrganophosphorus
isopropylphosphoramidothioate
Omethoate1113-02-6350022285Insecticide,Organophosphorus
Breakdown
product
Oxydemeton-methyl301-12-258702382InsecticideOrganophosphorus
Paraoxon311-45-5NA 1554082BreakdownOrganophosphorus
product
Parathion56-38-257501459InsecticideOrganophosphorus
Parathion56-38-257401NA 174Insecticide,Organophosphorus
Nematicide
Parathion, other relatedNA 1099NA 16390459Insecticide,Organophosphorus
Nematicide
Phenkapton2275-14-1#####NA 139InsecticideOrganophosphorus
Phenthoate253180#####NA 889InsecticideOrganophosphorus
Phorate298-02-257201478Insecticide,Organophosphorus
Nematicide
Phorate sulfone249924NA 1554084BreakdownOrganophosphorus
product
Phorate sulfoxide249892NA 1554085BreakdownOrganophosphorus
product
Phoratoxon2600-69-3NA 1554086BreakdownOrganophosphorus
product
Phoratoxon sulfoneNA 1051NA 1554087BreakdownOrganophosphorus
product
Phoratoxon sulfoxide249955NA 1554088BreakdownOrganophosphorus
product
Phosalone2310-17-097701479InsecticideOrganophosphorus
Phosalone OANA 1066977015041Insecticide,Organophosphorus
Breakdown
product
Phosfolan947-02-4#####NA 131N/AOrganophosphorus
Phosmet732-11-659201335InsecticideOrganophosphorus
Phosmetoxon3735-33-9592024089BreakdownOrganophosphorus
product
Phosnichlor5826-76-634503NA 302InsecticideOrganophosphorus
Phosphamidon13171-21-618201482InsecticideOrganophosphorus
Phosphamidon, other relatedNA 1104NA 16390482InsecticideOrganophosphorus
Phostebupirim96182-53-5#####5122InsecticideOrganophosphorus
Phoxim14816-18-3#####NA 159InsecticideOrganophosphorus
Phoxim-methyl14816-16-1#####NA 159InsecticideOrganophosphorus
Piperophos24151-93-7NA 219NA 218HerbicideOrganophosphorus
Pirimiphos ethyl23505-41-1#####2781InsecticideOrganophosphorus
Pirimiphos ethyl, O-analog36378-61-7#####NA 899BreakdownOrganophosphorus
product
Pirimiphos-methyl29232-93-7#####2217InsecticideOrganophosphorus
Primidophos39247-96-6#####NA 127InsecticideOrganophosphorus
Profenofos41198-08-7#####2042InsecticideOrganophosphorus
Propaphos7292-16-2NA 201NA 201InsecticideOrganophosphorus
Propetamphos31218-83-4#####2122InsecticideOrganophosphorus
Propoxon5823-13-2#####NA 139InsecticideOrganophosphorus
Prothidathion20276-83-9#####NA 141InsecticideOrganophosphorus
Prothiofos34643-46-4#####4094InsecticideOrganophosphorus
Prothion5969-94-8#####NA 139InsecticideOrganophosphorus
Prothoate2275-18-5#####NA 140InsecticideOrganophosphorus
Pyraclofos77458-01-6NA 183NA 182InsecticideOrganophosphorus
Pyrazophos13457-18-6#####NA 149FungicideOrganophosphorus
Pyridiphenthion119-12-053302NA 450InsecticideOrganophosphorus
Quinalphos13593-03-8#####NA 145InsecticideOrganophosphorus
Quinalphos-methyl13593-08-3#####NA 145InsecticideOrganophosphorus
Quinitofos1776-83-6#####NA 149InsecticideOrganophosphorus
Quinothion22439-40-3#####NA 140InsecticideOrganophosphorus
Ronnel299-84-358301517InsecticideOrganophosphorus
S,S,S-tributyl78-48-874801190Defoliant, PlantOrganophosphorus
phosphorotrithioateGrowth
Regulator
S-(1,1-Dimethylethyl) O-ethyl83318-76-7#####NA 104InsecticideOrganophosphorus
ethylphosphonothioate
S-(4-(1,1-329-21-5#####NA 143InsecticideOrganophosphorus
dimethylethyl)phenyl) O-ethyl
ethylphosphonodithioate
Sophamide37032-15-8#####NA 144InsecticideOrganophosphorus
Sulfotep3689-24-579501558InsecticideOrganophosphorus
Sulfotep, other relatedNA 1111NA 16490558InsecticideOrganophosphorus
Sulprofos35400-43-2#####2006InsecticideOrganophosphorus
Sulprofos oxon38527-90-1#####NA 125BreakdownOrganophosphorus
product
Temephos3383-96-8590011InsecticideOrganophosphorus
Temephos sulfoxide17210-55-859002NA 483BreakdownOrganophosphorus
product
TEPP107-49-379601577InsecticideOrganophosphorus
Terbufos13071-79-9#####2925Insecticide,Organophosphorus
Nematicide
Terbufos sulfone56070-16-7#####NA 140BreakdownOrganophosphorus
product
Terbufos sulfoxide10548-10-4#####NA 140BreakdownOrganophosphorus
product
Tetrachlorvinphos22248-79-983702305InsecticideOrganophosphorus
Tetrachlorvinphos961-11-583701NA 34InsecticideOrganophosphorus
Thiometon640-15-3#####NA 149InsecticideOrganophosphorus
Thionazin297-97-2324012939InsecticideOrganophosphorus
Thionazin, O-analog7359-55-932402NA 297Insecticide,Organophosphorus
Breakdown
product
Tolclofos-methyl57018-04-9#####NA 106FungicideOrganophosphorus
Triazophos24017-47-8#####3543InsecticideOrganophosphorus
Trichlorfon52-68-65790188InsecticideOrganophosphorus
Trichloronat327-98-0#####5001InsecticideOrganophosphorus
Vamidothion2275-23-2#####3544InsecticideOrganophosphorus
3-iodo-2-propynyl butyl55406-53-6#####1938Fungicide,Other Carbamate
carbamateWood
Preservative
6-Methyl-2-propyl-4-2532-49-2#####NA 157N/AOther Carbamate
pyrimidinyl dimethylcarbamate
Alanycarb83130-01-2NA 175NA 47InsecticideOther Carbamate
Asulam3337-71-1#####5076HerbicideOther Carbamate
Asulam, sodium salt2302-17-2#####1746HerbicideOther Carbamate
Benfuracarb82560-54-1#####NA 48InsecticideOther Carbamate
Chlorbufam1967-16-4#####NA 157HerbicideOther Carbamate
Chlorprocarb23121-99-5#####NA 136HerbicideOther Carbamate
Chlorpropham101-21-318301141Herbicide,Other Carbamate
Plant Growth
Regulator
Diethofencarb87130-20-9NA 184NA 183FungicideOther Carbamate
Dimetan122-15-6#####NA 112InsecticideOther Carbamate
Dimetilan644-64-490101NA 844InsecticideOther Carbamate
Fenoxycarb79127-80-3#####2283Insecticide,Other Carbamate
Insect Growth
Regulator
Fenoxycarb72490-01-8NA 228NA 228Insecticide,Other Carbamate
Insect Growth
Regulator
Isolan119-38-0#####NA 155InsecticideOther Carbamate
Karbutilate4849-32-597401691HerbicideOther Carbamate
Mecarbinizid27386-64-7#####NA 157N/AOther Carbamate
Nitrilacarb29672-19-3#####NA 129InsecticideOther Carbamate
Potassium asulam14089-43-1#####NA 893HerbicideOther Carbamate
Propamocarb24579-73-5#####2147FungicideOther Carbamate
Propamocarb hydrochloride25606-41-1#####4022FungicideOther Carbamate
Propham122-42-947601339Herbicide,Other Carbamate
Plant Growth
Regulator
Pyrolan87-47-8#####NA 157InsecticideOther Carbamate
Swep1918-18-9846014098N/AOther Carbamate
Chlorfenapyr122453-73-0#####3938InsecticidePyrazole
Pyrazoxyfen71561-11-0NA 189NA 189HerbicidePyrazole
Tebufenpyrad119168-77-390102NA 845InsecticidePyrazole
(+−)-cis,trans-Deltamethrin120710-23-8#####NA 120InsecticidePyrethroid
(+−)-cis-Permethrin52341-33-0#####NA 120InsecticidePyrethroid
(S)-Cypermethrin66841-24-5#####3866InsecticidePyrethroid
6-chloropiperonyl 2,2-70-43-9#####NA 124InsecticidePyrethroid
dimethyl-3-(2-
methylpropenyl)cyclopropanecarboxylate
Acrinathrin101007-06-1#####NA 4InsecticidePyrethroid
Allethrin584-79-2400112InsecticidePyrethroid
Allethrin CoilNA 11634002NA 163InsecticidePyrethroid
Allethrin, other relatedNA 1070NA 16090012InsecticidePyrethroid
B-fenvalerate66267-77-4#####NA 903InsecticidePyrethroid
Beta-cyfluthrin68359-37-5#####3956InsecticidePyrethroid
Bifenthrin82657-04-3#####2300InsecticidePyrethroid
Bioresmethrin28434-01-797802NA 855InsecticidePyrethroid
Cismethrin35764-59-197804NA 857InsecticidePyrethroid
Cyclethrin97-11-04052NA 69N/APyrethroid
Cycloprothrin63935-38-6NA 204NA 203InsecticidePyrethroid
Cyfluthrin68359-37-5#####2223InsecticidePyrethroid
Cyhalothrin68085-85-8#####NA 104InsecticidePyrethroid
Cypermethrin (stereochemistry52315-07-8#####NA 172InsecticidePyrethroid
unspecified)
Cypermethrin, alpha67375-30-8#####NA 120InsecticidePyrethroid
Cypermethrin, beta65731-84-2#####2171InsecticidePyrethroid
Cypermethrin, theta71697-59-1NA 200NA 199InsecticidePyrethroid
Cyphenothrin39515-40-7#####3885InsecticidePyrethroid
D-Allethrin42534-61-240052293InsecticidePyrethroid
D-allethrin, other relatedNA 1151NA 16892293InsecticidePyrethroid
D-cis-trans Allethrin42534-61-24005NA 163InsecticidePyrethroid
D-trans Allethrin28057-48-940034038InsecticidePyrethroid
D-trans allethrin, other relatedNA 1154NA 17394038InsecticidePyrethroid
Deltamethrin52918-63-5978053010InsecticidePyrethroid
Deltamethrin (isomer52820-00-5#####NA 120InsecticidePyrethroid
unspecified)
Deltamethrin, other relatedNA 1153NA 16993010InsecticidePyrethroid
Dimethrin70-38-234101NA 299InsecticidePyrethroid
Empenthrin [(1R)isomers]54406-48-3NA 202NA 202InsecticidePyrethroid
Esbiothrin28434-00-640044040InsecticidePyrethroid
Esfenvalerate66230-04-4#####2321InsecticidePyrethroid
Fenpropathrin39515-41-8#####2234InsecticidePyrethroid
Fenpropathrin64257-84-7NA 201NA 200InsecticidePyrethroid
Fenvalerate51630-58-1#####1963InsecticidePyrethroid
Fenvalerate51630-58-1#####NA 173InsecticidePyrethroid
Fenvalerate, other relatedNA 1143NA 16791963InsecticidePyrethroid
Flucythrinate70124-77-5#####2168InsecticidePyrethroid
Flumethrin69770-45-2NA 219NA 218InsecticidePyrethroid
Fluvalinate (stereochemistry69409-94-5#####2195InsecticidePyrethroid
unspecified)
Furethrin17080-02-3#####NA 150InsecticidePyrethroid
Halfenprox111872-58-3NA 189NA 188InsecticidePyrethroid
Imiprothrin72963-72-540065327InsecticidePyrethroid
Lambda cyhalothrin91465-08-6#####2297InsecticidePyrethroid
Permethrin52645-53-1#####2008InsecticidePyrethroid
Permethrin, other relatedNA 1146NA 16892008InsecticidePyrethroid
Phenothrin26002-80-2690052093InsecticidePyrethroid
Phenothrin, other relatedNA 1147NA 16892093InsecticidePyrethroid
Prallethrin23031-36-9#####3985InsecticidePyrethroid
Pyrethrins and pyrethroids,68648-44-269007NA 611InsecticidePyrethroid
manufg. Residues
Resmethrin10453-86-8978012119InsecticidePyrethroid
Resmethrin, other relatedNA 1148NA 16892119InsecticidePyrethroid
S-Bioallethrin28434-00-640044039InsecticidePyrethroid
Tau-fluvalinate102851-06-9NA 201NA 200InsecticidePyrethroid
Tefluthrin79538-32-2#####3839InsecticidePyrethroid
Tetramethrin7696-12-0690031695InsecticidePyrethroid
Tetramethrin, other relatedNA 1137NA 16791695InsecticidePyrethroid
Tralomethrin66841-25-6#####2329InsecticidePyrethroid
Transfluthrin118712-89-3NA 206NA 205InsecticidePyrethroid
(Poly-N-acetyl--D-9012-76-4#####2792Plant GrowthAnimal derived
glucosamine)-proteinRegulator,
Fungicide
Ammoniated caseinate9005-42-9NA 5393579N/AAnimal derived
Androsterone53-41-8#####NA 101Deer RepellentAnimal derived
Animal gland extractsNA 63NA 1181345RodenticideAnimal derived
Animal glueNA 792NA 1473581Rodenticide,Animal derived
Bird Repellent
Beef fatNA 637NA 1173585BaitAnimal derived
Bone mealNA 584NA 1063589N/AAnimal derived
Bone oil8001-85-21080178Dog and CatAnimal derived
Repellent
Calcium salts of casein and soyNA 665NA 1231252N/AAnimal derived
Casein9000-71-9NA 1521075N/AAnimal derived
Cat foodNA 796NA 1473602BaitAnimal derived
CheeseNA 222NA 4293604BaitAnimal derived
Chitin1398-61-4#####NA 109NematicideAnimal derived
Clam shellsNA 797NA 1473611N/AAnimal derived
Cod liver oil8001-69-2316092250N/AAnimal derived
Dried blood68911-49-96111315Dog and CatAnimal derived
Repellent
Dry milk solidsNA 149NA 2841976N/AAnimal derived
Egg shellsNA 141NA 2753649N/AAnimal derived
EggsNA 802NA 1483648N/AAnimal derived
Elanco empty gelatin capsulesNA 142NA 2762543N/AAnimal derived
Fish mealNA 123NA 2372571N/AAnimal derived
Fish oil8016-13-5#####3658Adjuvant, DeerAnimal derived
Repellent, Dog
and Cat
Repellent
Game repellentNA 1490NA 221NA 221Deer RepellentAnimal derived
Gardol137-16-61743210Dog and CatAnimal derived
Repellent
Gelatin9000-70-8NA 2223660InsecticideAnimal derived
Gelatin capsules, R. P. SchererNA 574NA 1042577N/AAnimal derived
Hydrolyzed proteinsNA 1355NA 192NA 192BaitAnimal derived
JaguarNA 76NA 1472146Deer RepellentAnimal derived
Lard61789-99-9NA 1433675N/AAnimal derived
Lion wasteNA 571NA 1031301Deer RepellentAnimal derived
MeatNA 53NA 1003681BaitAnimal derived
Meat mealNA 570#####3682Bait, DeerAnimal derived
Repellent, Dog
and Cat
Repellent
Meat scrapsNA 54NA 1013683BaitAnimal derived
Meat stock, Hormel #6NA 618NA 1122670BaitAnimal derived
Milk8049-98-7NA 643564N/AAnimal derived
Nutria meatNA 24NA 363702BaitAnimal derived
Oil of minkNA 10NA141961N/AAnimal derived
Oyster shellsNA 808NA 1493714N/AAnimal derived
Pig tastiesNA 594NA 1073730N/AAnimal derived
Powdered gelatinNA 760NA 1372827N/AAnimal derived
Putrescent whole egg solids51609-52-0#####1935Insecticide,Animal derived
Deer Repellent
Shellac9000-59-3NA 1093378N/AAnimal derived
Silkworm pupaeNA 464NA 8282855N/AAnimal derived
Sodium caseinate9005-46-3NA 8363389N/AAnimal derived
Sperm oil8002-24-299701NA 868N/AAnimal derived
WheyNA 560NA 1013825N/AAnimal derived
WoolNA 566NA 1023826N/AAnimal derived
(−)-.alpha.-Cubebene17699-14-8#####NA 130InsecticideBotanical
(7S)-Hydroprene65733-18-8#####NA 107Insect GrowthBotanical
Regulator
1-naphthaleneacetamide86-86-256001422Plant GrowthBotanical,
(NAD)RegulatorNaphthalene acetic
acid derivati
2-methoxy-5-nitro phenol,67233-85-6#####5117Plant GrowthBotanical
sodium saltRegulator
2-NaphthyloxyacetamideNA 1401NA 197NA 196Plant GrowthNaphthalene acetic
Regulator,acid derivati,
HerbicideBotanical
3,7-dimethyl-6-octanol106-22-9NA 1292140InsectBotanical
Repellent
3,7-dimethyl-6-octen-1-ol150-84-5NA 3072522InsectBotanical
acetateRepellent
Acacia2591766NA 6962346N/ABotanical
AlfalfaNA 635NA 1163569N/ABotanical
Alfalfa mealNA 393NA 7143570N/ABotanical
Algin9005-38-3NA 7153571N/ABotanical
Almond hullsNA 280NA 5473577N/ABotanical
Almond shellsNA 636NA 1173578N/ABotanical
Alpha-ionone127-41-3#####1518Dog and CatBotanical
Repellent
Alpha-pinene polymer31393-98-3NA 1533996InsecticideBotanical
Amycol potato alpha starchNA 272NA 5272387N/ABotanical
Apple pomaceNA 262NA 5173582N/ABotanical
Avermectin71751-41-2#####2254InsecticideBotanical
Avermectin B165195-55-3#####NA 165InsecticideBotanical
Avermectin, other relatedNA 1156NA 17492254InsecticideBotanical
Azadirachtin11141-17-6#####2328Insecticide,Botanical
Nematicide
Azadirachtin B95507-03-2#####NA 989InsecticideBotanical
Balsam peruNA 660NA 1221146N/ABotanical
Barley strawNA 873NA 1605138N/ABotanical
Beeswax (yellow and white)NA 245NA 4943586N/ABotanical
Beet powderNA 246NA 4953587N/ABotanical
Beta-caryophyllene87-44-5NA 4392188N/ABotanical
Beta-pinene polymer68240-09-5NA 1533998InsecticideBotanical
BranNA 638NA 1173590N/ABotanical
Bread crumbsNA 793NA 1473591BaitBotanical
Buffalo gourd root powderNA 238NA 4753928N/ABotanical
Calf's Milk ReplacerNA 1320NA 1775741N/ABotanical
Canary seedNA 583NA 1053597BaitBotanical
Capsicum oleoresin404-86-470701470InsecticideBotanical
CardboardNA 795NA 1473599N/ABotanical
Carrageenan2591943NA 4373600AdjuvantBotanical
CarrotsNA 226NA 4383601N/ABotanical
Chlorophyllin11006-34-1NA 191NA 190Fungicide,Inorganic-Copper,
MicrobiocideBotanical
Cinerin I25402-06-669009NA 612InsecticideBotanical
Cinerin II121-20-069010NA 613InsecticideBotanical
Cinnamaldehyde104-55-2405062277Dog and CatBotanical
Repellent,
Fungicide, Dog
and Cat
Repellent
CinnamonNA 217#####3607InsecticideBotanical
cis-ZeatinNA 1342NA 191NA 190Plant GrowthBotanical
Regulator
Citronellal106-23-0NA 223NA 223InsectBotanical
Repellent
Citronellol106-22-9NA 3062139InsecticideBotanical
Citrus extractNA 1457NA 216NA 215N/ABotanical
Citrus mealNA 214NA 4073608N/ABotanical
Citrus pectinNA 215NA 4083609N/ABotanical
Citrus pulpNA 216NA 4093610N/ABotanical
Clarified hydrophobic extract8002-65-1250063979InsecticideBotanical
of neem oil
Clarified hydrophobic neem oil8002-65-125007NA 172InsecticideBotanical
Cloves, CrushedNA 962#####2333InsecticideBotanical
Coco shell flourNA 200NA 3923617N/ABotanical
CocoaNA 207NA 3983613N/ABotanical
Cocoa shellsNA 640NA 1173614N/ABotanical
Coffee groundsNA 581NA 1053619N/ABotanical
Components of etheric oils ofNA 1360NA 193NA 192InsecticideBotanical
plant origin
CorkNA 798NA 1473622N/ABotanical
CornNA 879NA 1695144BaitBotanical
Corn cobsNA 193NA 3833624N/ABotanical
Corn flourNA 799NA 1473625N/ABotanical
Corn gluten meal66071-96-3#####2481HerbicideBotanical
Corn product, hydrolyzedNA 710NA 1302322HerbicideBotanical
CottonNA 188NA 3763629N/ABotanical
Cotton fibre cordNA 189NA 3772482N/ABotanical
Cottonseed flour12751-36-9NA 1292078N/ABotanical
Cottonseed mealNA 190NA 3783630N/ABotanical
Cracked oatsNA 801NA 1483632BaitBotanical
Cracked wheatNA 192NA 3803633BaitBotanical
Creosote, wood8021-39-425002NA 202WoodBotanical
Preservative
Cube extractsNA 95871004756InsecticideBotanical
Cytokinin525-79-1#####2082Plant GrowthBotanical
Regulator
Cytokinin (as kinetin)525-79-1#####NA 172Plant GrowthBotanical
Regulator
Daphne oilNA 1354NA 192NA 192InsectBotanical
Repellent
Derris resins other thanNA 126071001NA 172InsecticideBotanical
rotenone
DesmodiumNA 1560NA 227NA 227InsecticideBotanical
Digitalis71-63-697002NA 850N/ABotanical
Digitalis1339-93-197002NA 851N/ABotanical
Dihydroazadirachtin108189-58-8#####3994Insecticide,Botanical
Nematicide
DMN571-58-4558025067Plant GrowthBotanical
Regulator
Douglas fir bark, groundNA 156NA 2923647N/ABotanical
Emamectin, benzoate137512-74-4#####4020InsecticideBotanical
Ethylene glycol ether of pinene53404-49-242101NA 363InsecticideBotanical
Eugenol97-53-0#####2095Pheromone,Botanical
Fragrance, Dog
and Cat
Repellent,
Insecticide,
Insect
Repellent
FenugreekNA 121NA 2343657N/ABotanical
FlourNA 120NA 2323659N/ABotanical
Flowers of ChamomileNA 1267#####NA 173InsecticideBotanical
(Matricaria chamomilla and/or
Anthemidis nobilis)
Folic acid59-30-3NA 191NA 190Plant GrowthBotanical
Regulator
Garlic8000-78-0#####2213InsecticideBotanical
Geraniol106-24-1#####309Pheromone,Botanical
Fragrance,
Insecticide,
Insect
Repellent, Dog
and Cat
Repellent
Gibberellic acid, 2-butoxyethyl6550-86-343803NA 371Plant GrowthBotanical
esterRegulator
Gibberellin A4 mixt. With8030-53-3#####NA 952Plant GrowthBotanical
gibberellin A7Regulator
Gibberellins77-06-543801310Plant GrowthBotanical
Regulator
Gibberellins, potassium salt125-67-743802771Plant GrowthBotanical
Regulator
Grape pomaceNA 880NA 1695145N/ABotanical
Griseofulvin126-07-8#####NA 150N/ABotanical
Ground corn cobsNA 732NA 1332583N/ABotanical
Ground oatsNA 804NA 1483664BaitBotanical
Ground rice hullsNA 108NA 2122584N/ABotanical
Ground sesame plantNA 109#####2585Insecticide,Botanical
Nematicide
Guar gum9000-30-0NA 1033666AdjuvantBotanical
Gum resins9000-75-399401NA 866AdjuvantBotanical
Gum Thus224496784502NA 834AdjuvantBotanical
Gum tragacanth9000-65-1NA 2133218AdjuvantBotanical
Hearts of corn flourNA 573NA 1043667N/ABotanical
Hellebore alkaloids1399-70-82001NA 65N/ABotanical
Humic acid1415-93-6NA 1342597N/ABotanical
Hydroprene41096-46-2#####2244Insect GrowthBotanical
Regulator
Indole120-72-9250002614Insecticide,Botanical
Insect
Repellent, Dog
and Cat
Repellent
Indole-3-acetic acid87-51-4#####NA 106Plant GrowthBotanical
Regulator
Jasmolin I4466-14-269011NA 614InsecticideBotanical
Jasmolin II1172-63-069012NA 615InsecticideBotanical
Juniper tar oil223154367203NA 575InsecticideBotanical
Juniperus communis ext.84603-69-067212NA 582InsecticideBotanical
Larkspur alkaloid41710-20-72202NA 66N/ABotanical
Leaves of EucalyptusNA 1277#####NA 174InsecticideBotanical
Leaves of Pennyroyal (MenthaNA 1278#####NA 174InsecticideBotanical
pulegium)
LigninNA 73NA 1402640N/ABotanical
Lilacin118-34-367006NA 573N/ABotanical
Linalool78-70-6#####2239Insecticide,Botanical
Insect
Repellent,
Fragrance
Locust bean gumNA 738NA 1342647AdjuvantBotanical
Medicated feedNA 644NA 1183685N/ABotanical
Millet seedNA 38NA 653692BaitBotanical
Mint HerbsNA 1280#####NA 174InsecticideBotanical
Montok pepperNA 851NA 1585012InsecticideBotanical
Myrica cerifera, extract84929-34-0#####NA 123N/ABotanical
N6-Benzyladenine, mixt. with53663-71-1#####NA 953Plant GrowthBotanical
Gibberellins A4 and A7Regulator
NAA86-87-356002423Plant GrowthNaphthalene acetic
Regulatoracid derivati,
Botanical
NAA, ethyl ester2122-70-556008749Plant GrowthNaphthalene acetic
Regulatoracid derivati,
Botanical
Nicotine54-11-55670275InsecticideBotanical
Nicotine sulfate65-30-556703430InsecticideBotanical
NOA120-23-055601432Plant GrowthNaphthalene acetic
Regulatoracid derivati,
Botanical
Nonanoic acid112-05-0#####2739Herbicide,Botanical
Fungicide
OatmealNA 806NA 1493704BaitBotanical
OatsNA 16NA 263705BaitBotanical
Oil of cedarwood8000-27-9405051011Insecticide,Botanical
Fungicide
Oil of hardwoodNA 675672011639MicrobiocideBotanical
Oil of pine tar2227495670022246Insecticide,Botanical
Microbiocide
Oils, cedarwood, Texan68990-83-011524NA 118Insecticide,Botanical
Fungicide
Onion extractNA 1349NA 192NA 191N/ABotanical
OnionsNA 807NA 1493711N/ABotanical
Orange pulpNA 9NA 133712N/ABotanical
p-Menthane-3,8-diol42822-86-6115505255InsectBotanical
Repellent
Paloja9000-28-6#####NA 880N/ABotanical
Papain9001-73-4NA 1493717RodenticideBotanical
PaperNA 598NA 1073718N/ABotanical
PaprikaNA 383NA 6923719N/ABotanical
Peanut butterNA 373NA 6812735BaitBotanical
Peanut shellsNA 375NA 6833723N/ABotanical
PeanutsNA 374NA 6823533BaitBotanical
Peat mossNA 809NA 1493724N/ABotanical
Pecan shell flourNA 376NA 6843725N/ABotanical
Pectin9000-69-5NA 1183726N/ABotanical
PepperNA 1348NA 192NA 191Insecticide,Botanical
Deer Repellent
PeppermintNA 365NA 6682332Insecticide,Botanical
Fragrance
Phenylethyl propionate122-70-3#####2094Fragrance,Botanical
Pheromone,
Insecticide,
Insect
Repellent, Dog
and Cat
Repellent
Pine oil222749567002485Insecticide,Botanical
Microbiocide
Pine soapNA 1032NA 1271993Insecticide,Botanical
Microbiocide
Pine tar8011-48-1672041574Insecticide,Botanical
Microbiocide
Pine tar oil91995-59-467205NA 576Insecticide,Botanical
Microbiocide
Pinene80-56-8670042187InsecticideBotanical
Pinene1330-16-167001NA 572InsecticideBotanical
Plant carbolineumsNA 1454NA 215NA 215Insecticide,Botanical
Fungicide
Plant extract (derived fromNA 917#####5453NematicideBotanical
Quercus falcata, Opuntia
lindheimeri, Rhus aromatica,
and Rhizophoria mangle
tissues)
Polymerized pineneNA 399NA 7222043InsecticideBotanical
PotatoesNA 436NA 7863772N/ABotanical
Poultry feedNA 437NA 7873773N/ABotanical
Pyrethrin coilsNA 116569004NA 164InsecticideBotanical
Pyrethrin I121-21-1NA 213NA 213InsecticideBotanical
Pyrethrin II121-29-969006NA 610InsecticideBotanical
Pyrethrins8003-34-769001510InsecticideBotanical
Pyrethrins, other relatedNA 1108NA 16490510InsecticideBotanical
Pyrethrum narcNA 1000690001461InsecticideBotanical
Pyrethrum powder other than8003-34-769002NA 164InsecticideBotanical
pyrethrins
QuassiaNA 450NA 8063778InsecticideBotanical
Quillaja68990-67-0NA 1503779N/ABotanical
RaisinsNA 647NA 1193780BaitBotanical
Red dog flourNA 452NA 8113782N/ABotanical
Red pepperNA 107707031094Dog and CatBotanical
Repellent
Red squill glycoside507-60-870801514RodenticideBotanical
Repellants (by smell) of animalNA 1373NA 194NA 193Dog and CatBotanical
or plant originRepellent, Deer
Repellent
Resins, oleo-, capsicum8023-77-670704NA 665InsecticideBotanical
RiceNA 812NA 1503783N/ABotanical
Rice hullsNA 813NA 1503784N/ABotanical
RosemaryNA 453#####2331N/ABotanical
Rosin9014-63-5NA 8123785N/ABotanical
Rosin oil8002-16-240508NA 341N/ABotanical
Rosin, partially dimerizedNA 454NA 8133786N/ABotanical
Rosin, partially hydrogenated65997-06-0NA 1503787N/ABotanical
Rotenone83-79-471003518InsecticideBotanical
Rotenone, other relatedNA 1109NA 16490518InsecticideBotanical
Rubber2594048NA 8143788N/ABotanical
RyanodineNA 130571502NA 175InsecticideBotanical
Ryanodine alkaloid15662-33-671501520InsecticideBotanical
Rye flourNA 648NA 1193789N/ABotanical
Sabadilla alkaloids22451802201521InsecticideBotanical
Safrole94-59-7979013376N/ABotanical
Saponin8047-15-2970045033N/ABotanical
SawdustNA 1306#####1316AdjuvantBotanical
Scratch feedNA 649NA 1193792N/ABotanical
Sea-algae extractNA 1352NA 192NA 191Plant GrowthBotanical
Regulator,
Adjuvant
SeaweedNA 814NA 1503793N/ABotanical
Sodium 2-nitrophenoxide824-39-5#####5118Plant GrowthBotanical
Regulator
Sodium 4-nitrophenoxide824-78-2#####5119Plant GrowthBotanical
Regulator
Sorghum, grainNA 478NA 8823904N/ABotanical
Soy flourNA 482NA 8863809N/ABotanical
Soy proteinNA 483NA 8873810N/ABotanical
Soybean extractNA 1353NA 192NA 191N/ABotanical
Soybean hullsNA 481NA 8853807N/ABotanical
Soybean mealNA 817NA 1503808N/ABotanical
Squalane111-01-3455032887N/ABotanical
Sugarbeet mealNA 499NA 9103813N/ABotanical
Sunflower seedsNA 650NA 1193815BaitBotanical
Synthetic vegetable gums9004-64-2NA 9211835AdjuvantBotanical
Tall oil8002-26-4672112912AdjuvantBotanical
Tall oil acids61790-12-3NA 1241389AdjuvantBotanical
Tar oils, from distillation of8002-29-767202NA 574Insecticide,Botanical
wood tarHerbicide
Thuringiensin, calcium23526-02-564042941InsecticideBotanical
technical
ThymeNA 527#####2330InsectBotanical
Repellent,
Insecticide
TobaccoNA 1011NA 9593932InsecticideBotanical
Tobacco dust8037-19-256704NA 469InsecticideBotanical
Trimethoxybenzene135-77-3405155064Insecticide,Botanical
Insect
Repellent, Dog
and Cat
Repellent
Tung oilNA 547NA 9973821N/ABotanical
Verbenone1196-01-6#####NA 108InsectBotanical
Repellent
Walnut flourNA 555NA 1013823N/ABotanical
Walnut shells, groundNA 556NA 1012986N/ABotanical
WheatNA 819NA 1513824N/ABotanical
Wheat flourNA 674NA 1251577N/ABotanical
White pepperNA 1311NA 178NA 177InsecticideBotanical
Wood powderNA 565NA 1021463N/ABotanical
Wood rosin224503167208NA 579N/ABotanical
Wood tar91722-33-767206NA 577InsecticideBotanical
Xanthan gum11138-66-2NA 1022272AdjuvantBotanical
Agrobacterium radiobacter varNA 1435NA 211NA 210FungicideMicrobial
radiobacter
Agrobacterium radiobacterNA 693NA 1271984FungicideMicrobial
Agrobacterium radiobacterNA 925#####NA 167FungicideMicrobial
(strain K84)
Agrobacterium radiobacterNA 92164745477FungicideMicrobial
strain K1026
Agrobacterium vitisNA 1536NA 224NA 224FungicideMicrobial
Agrotis segetum granulosisNA 1391NA 196NA 195InsecticideMicrobial
virus
Ampelomyces quisqualisNA 270NA 5252385FungicideMicrobial
Ampelomyces quisqualisNA 121721007NA 170FungicideMicrobial
isolate M-10
Anagrapha falcifera multi-NA 862#####5089InsecticideMicrobial
nuclear polyhedrosis virus
(AFMNPV)
Aschersonia aleyrodisNA 1392NA 196NA 195InsecticideMicrobial
Bacillus cereus strain UW85NA 1218#####NA 170Plant GrowthMicrobial
Regulator
Bacillus cereus, strain BP01NA 903NA 1725183InsecticideMicrobial
Bacillus popilliaeNA 257NA 5092183FungicideMicrobial
Bacillus popilliae and B. lentimorbusNA 121954501NA 170FungicideMicrobial
Bacillus sphaericus143447-72-7#####2274InsecticideMicrobial
Bacillus sphaericus, serotype143447-72-7#####2409InsecticideMicrobial
H-5A5B, strain 2362
Bacillus subtilis GBO3NA 855#####3945FungicideMicrobial
Bacillus subtilis isolate B246NA 1538NA 225NA 224FungicideMicrobial
Bacillus subtilis MBI 600NA 864#####5120FungicideMicrobial
Bacillus subtilis var.NA 12206480NA 170Fungicide,Microbial
Amyloliquefaciens StrainPlant Growth
FZB24Regulator
Bacillus thuringiensis (berliner)68038-71-1640086InsecticideMicrobial
Bacillus thuringiensis68038-71-164263843InsecticideMicrobial
(berliner), subsp. Aizawai, GC-
91 protein
Bacillus thuringiensis68038-71-164003856InsecticideMicrobial
(berliner), subsp. Aizawai,
serotype H-7
Bacillus thuringiensis68038-71-164013857InsecticideMicrobial
(berliner), subsp. Israelensis,
serotype H-14
Bacillus thuringiensis68038-71-164023970InsecticideMicrobial
(berliner), subsp. Kurstaki
strain SA-12
Bacillus thuringiensis68038-71-164023858InsecticideMicrobial
(berliner), subsp. Kurstaki,
serotype 3a, 3b
Bacillus thuringiensis68038-71-164243859InsecticideMicrobial
(berliner), subsp. Kurstaki,
strain EG2348
Bacillus thuringiensis68038-71-164233860InsecticideMicrobial
(berliner), subsp. Kurstaki,
strain EG2371
Bacillus thuringiensis68038-71-164223861InsecticideMicrobial
(berliner), subsp. Kurstaki,
strain EG2424
Bacillus thuringiensis68038-71-164023862InsecticideMicrobial
(berliner), subsp. Kurstaki,
strain SA-11
Bacillus thuringiensisNA 148164003863InsecticideMicrobial
(berliner), subsp. Morrisoni,
serotype 8a8b
Bacillus thuringiensis68038-71-164003864InsecticideMicrobial
(berliner), subsp. San Diego
Bacillus thuringiensis68038-71-164042410InsecticideMicrobial
darstadiensis
Bacillus thuringiensis sub.68038-71-164485051InsecticideMicrobial
Kurstaki strain EG7673
coleopteran active toxin
Bacillus thuringiensis sub.68038-71-164475049InsecticideMicrobial
Kurstaki strain EG7673
lepidopteran active toxin
Bacillus thuringiensis subsp.NA 12246403NA 170InsecticideMicrobial
Aizawai
Bacillus thuringiensis subsp.68038-71-164025004InsecticideMicrobial
Kurstaki, genetically
engineered strain AGRO1 by
Agrevo
Bacillus thuringiensis subsp.68038-71-164025005InsecticideMicrobial
Kurstaki, genetically
engineered strain AGRO2 by
Agrevo
Bacillus thuringiensis subsp.NA 1232#####NA 171InsecticideMicrobial
San Diego
Bacillus thuringiensis subsp.68038-71-164055043InsecticideMicrobial
Tenebrionis
Bacillus thuringiensis subspec.68038-71-1NA 1693972InsecticideMicrobial
Tenebrionis delta endotoxin
Bacillus thuringiensisNA 12346476NA 171InsecticideMicrobial
subspecies Israelensis strain
EG2215
Bacillus thuringiensis68038-71-164014018InsecticideMicrobial
subspecies Israelensis, strain
IPS-78
Bacillus thuringiensis68038-71-164074024InsecticideMicrobial
subspecies kurstaki strain BMP
123
Bacillus thuringiensis68038-71-164025010InsecticideMicrobial
subspecies Kurstaki strain HD-
1, lepidopteran active toxin
Bacillus thuringiensis68038-71-164533988InsecticideMicrobial
subspecies kurstaki, genetically
engineered strain EG7841
lepidopteran active toxin
Bacillus thuringiensis var.NA 12386445NA 171InsecticideMicrobial
kurstaki delta endotoxin protein
as produced by the Cry1A(c)
gene and its controlling
sequences
Bacillus thuringiensis var.68038-71-164523978InsecticideMicrobial
Kurstaki strain M-200 protein
toxin
Bacillus thuringiensis var.68038-71-164023962InsecticideMicrobial
Kurstaki, genetically
engineered strain ECX 9441
Bacillus thuringiensis var.68038-71-164595325InsecticideMicrobial
Kurstaki, genetically
engineered strain EG7826
Lepidopteran active toxin
Neodiprion sertifer nuclearNA 1389NA 196NA 195N/AMicrobial
polyhedrosis virus
Nosema locustae sporesNA 20#####2137InsecticideMicrobial
Nuclear polyhedrosis virusNA 1451NA 215NA 214InsecticideMicrobial
Nuclear polyhedrosis virus ofNA 1430NA 213NA 213N/AMicrobial
Helicoverpea zea
Nuclear polyhedrosis virus ofNA 1510NA 222NA 222InsecticideMicrobial
red-headed pine sawfly
Nystatin (streotomyces1400-61-9#####NA 115N/AMicrobial
noursei) (withdrawn: 23614-R:
pm24)
Paecilomyces fumosoroseusNA 831#####3964InsecticideMicrobial
apopka strain 97
Paecilomyces Lilacinus StrainNA 1439NA 213NA 213InsecticideMicrobial
251
Penicillin G, potassium saltNA 666NA 1231283N/AMicrobial
Peniophora giganteaNA 1462NA 217NA 216FungicideMicrobial
Phlebiopsis giganteaNA 1388NA 196NA 195FungicideMicrobial
Phytophthora palmivora,NA 860#####5078HerbicideMicrobial
chlamydospores of
Polyhedral inclusion bodies ofNA 593#####2009InsecticideMicrobial
Douglas fir tussock moth
nuclear polyhedrosis virus
Polyhedral inclusion bodies ofNA 1289#####NA 175InsecticideMicrobial
gypsy moth nucleopolyhedrosis
virus
Polyhedral inclusion bodies ofNA 1290#####NA 175InsecticideMicrobial
N. sertifer
Polyhedral occlusion bodiesNA 835#####4028InsecticideMicrobial
(OB's) of the nuclear
polyhedrosis virus of
Helicoverpa zea (corn
earworm)
Polyhedral occlusion bodiesNA 1292#####NA 175InsecticideMicrobial
(OBs) of the nuclear
polyhedrosis virus of
Autographa californica (alfalfa
looper)
Polyhedral occlusion bodiesNA 830NA 1534007InsecticideMicrobial
(OBs) of the nuclear
polyhedrosis virus of
Spodoptera exigua
Polyhedral occlusion bodies ofNA 1293#####NA 175InsecticideMicrobial
the beet armyworm nuclear
polyhedrosis virus
Pseudomonas aureofaciensNA 12966473NA 175FungicideMicrobial
strain Tx-1
Pseudomonas cepacia typeNA 44964193926Fungicide,Microbial
WisconsinNematicide
Pseudomonas chlororaphisNA 902NA 1725182FungicideMicrobial
Pseudomonas chlororaphisNA 14896478NA 220FungicideMicrobial
strain 63-28
Pseudomonas fluorescens EG-NA 85864405045FungicideMicrobial
1053
Pseudomonas fluorescensNA 86764393949FungicideMicrobial
1629RS
Pseudomonas fluorescensNA 102064382842FungicideMicrobial
A506
Pseudomonas fluorescensNA 86864203968FungicideMicrobial
strain NCIB 12089
Pseudomonas syringae strainNA 897NA 1713950N/AMicrobial
AGS31 Psedomonas syringae
strain PS31
Pseudomonas syringae strainNA 83664513967FungicideMicrobial
ESC-11
Pseudomonas syringae, strain68602-93-764112824FungicideMicrobial
742 RS
Pseudomonas syringae, strain68583-32-464413960FungicideMicrobial
ESC-10
Puccinia canaliculataNA 865#####5121HerbicideMicrobial
(Schweinitz) Lagerheim
(ATCC #40199)
QST 713 strain of driedNA 91564795447FungicideMicrobial
Bacillus subtilis
Rabbit CalicivirusNA 1441NA 214NA 213RodentMicrobial
Repellent
Rhizobium leguminosarumNA 1556NA 226NA 226InsecticideMicrobial
biovar phaseoli
Rhizobium leguminosarumNA 1557NA 226NA 226InsecticideMicrobial
viciaeTJ 9
Rhizobium melilotiNA 1558NA 227NA 226InsecticideMicrobial
Spinosad131929-60-7#####3983InsecticideMicrobial
Spinosyn D131929-63-0#####NA 907InsecticideMicrobial
Spores and mycelium spores ofNA 1446NA 214NA 214FungicideMicrobial
Phlebiopsis gigantea
Spores of Bacillus popilliaeNA 131054502NA 176FungicideMicrobial
Spores of GliocladiumNA 1453NA 215NA 215FungicideMicrobial
catenulatum
Streptomyces griseoviridisNA 875#####3937FungicideMicrobial
strain K61
Summerfruit tortrix mothNA 1491NA 221NA 221InsecticideMicrobial
granulosis virus
Tomato mosaic virusNA 1387NA 196NA 195N/AMicrobial
Trichoderma harzianum67892-34-6#####NA 106FungicideMicrobial
(ATCC 20476)
Trichoderma harzianum rifai67892-31-3#####3977FungicideMicrobial
strain KRL-AG2
Trichoderma harzianum Rifai67892-31-3#####4016FungicideMicrobial
strain T-39
Trichoderma polysporum67892-31-3#####NA 176FungicideMicrobial
(ATCC 20475)
Trichoderma polysporum rifaiNA 1067NA 1595101N/AMicrobial
Verticillium dahliae Kleb.NA 1386NA 196NA 195FungicideMicrobial
Verticillium lecanii67892-35-76421NA 96InsecticideMicrobial
Xanthomonas campestris pv.NA 910NA 1745317HerbicideMicrobial
Poannua
YeastNA 652NA 1193827N/AMicrobial
Allyl isothiocyanate57-06-749011010InsecticideOil - essential
Almond, bitter8013-76-1NA 5463576N/AOil - essential
Aloe vera oilNA 918NA 1755454N/AOil - essential
Blend of oils: of lemongrass, ofNA 1499NA 221NA 221InsecticideOil - essential
citronella, of orange, of
bergamot; geraniol, ionone
alpha, methyl salicylate and
allylisothioc
Camphor76-22-215602102Insecticide,Oil - essential
Fungicide,
Microbiocide
Camphor oil8008-51-315601NA 142Insecticide,Oil - essential
Fungicide,
Microbiocide
Canadian balsam8007-47-467209NA 580Insecticide,Oil - essential
Fungicide
Cedar leaf oil8007-20-340507NA 340Insecticide,Oil - essential
Fungicide
Cinnamon oilNA 922NA 1755577N/AOil - essential
Clove oil8000-34-8#####5018N/AOil - essential
Essential oils8014-17-3NA 121873InsecticideOil - essential
Eucalyptus oil8000-48-440503281InsectOil - essential
Repellent,
Insecticide
Fir needle oil8021-28-1#####NA 110N/AOil - essential
Lavandin oil8022-15-9405005017InsectOil - essential
Repellent,
Insecticide,
Dog and Cat
Repellent
Lemon peel oil8020-19-740518NA 346N/AOil - essential
Lime Oil8008-26-2NA 213NA 212InsecticideOil - essential
Limonene138-86-379701979InsectOil - essential
Repellent,
Insecticide,
Dog and Cat
Repellent
Limonene138-86-3797012531InsecticideOil - essential
Mixture citronella oil, citrusNA 1493NA 221NA 221InsectOil - essential
oil, eucalyptus oil, pine oilRepellent
Oil of ambergis8038-65-1#####NA 105N/AOil - essential
Oil of anise8007-70-343011051InsectOil - essential
Repellent,
Insecticide,
Dog and Cat
Repellent
Oil of bay8006-78-8405202072N/AOil - essential
Oil of bergamot8007-75-8#####1517InsectOil - essential
Repellent,
Insecticide,
Dog and Cat
Repellent
Oil of black pepperNA 1521NA 223NA 223InsecticideOil - essential
Oil of cajeput8008-98-840504NA 339N/AOil - essential
Oil of camphor sassafrassy8006-80-215603897N/AOil - essential
Oil of chamomile (Matricaria8002-66-2#####NA 104InsecticideOil - essential
chamomilla and/or Anthemidis
nobilis)
Oil of chenopodium8006-99-3NA 181524N/AOil - essential
Oil of citronella8000-29-121901143InsectOil - essential
Repellent, Dog
and Cat
Repellent
Oil of citrusNA 13NA 191931InsectOil - essential
Repellent
Oil of geranium8000-46-2#####1887FragranceOil - essential
Oil of jasmine8022-96-6405015063InsecticideOil - essential
Oil of jojoba61789-91-1672003833Insecticide,Oil - essential
Insect
Repellent,
Fungicide, Dog
and Cat
Repellent
Oil of lavender8000-28-0#####1888InsecticideOil - essential
Oil of lemon8008-56-8NA 120440N/AOil - essential
Oil of lemongrass5392-40-5405101009Insecticide,Oil - essential
Pheromone
Oil of lemongrass2229107405021136InsectOil - essential
Repellent,
Insecticide
Oil of mustard57-06-749011153InsectOil - essential
Repellent,
Insecticide,
Dog and Cat
Repellent
Oil of orange8008-57-940517441InsectOil - essential
Repellent,
Insecticide,
Dog and Cat
Repellent
Oil of pennyroyal8007-44-1405091325InsecticideOil - essential
Oil of peppermint8006-90-4NA 6692058InsecticideOil - essential
Oil of rosemary8000-25-7#####5450InsecticideOil - essential
Oil of rue8014-29-7405192206N/AOil - essential
Oil of spearmint8008-79-5#####1508N/AOil - essential
Oil of thyme8007-46-3#####NA 159N/AOil - essential
Oil of wintergreen119-36-876601746InsecticideOil - essential
Oils, tea-tree68647-73-428853NA 211N/AOil - essential
Orange pith oilNA 1461NA 217NA 216InsecticideOil - essential
Perfume, cherry fragrance oilNA 751NA 1362743FragranceOil - essential
#493
Phytelene of marigold70892-20-5#####NA 976N/AOil - essential
Phytelene of marigold84776-23-8#####NA 977N/AOil - essential
Tansy, sage and lavenderNA 1452NA 215NA 214InsecticideOil - essential
extracts
Vanillin121-33-5#####5149N/AOil - essential
Canola oil120962-03-0113325332Insecticide,Oil - vegetable
Adjuvant
Castor oil8001-79-4316081013Rodenticide,Oil - vegetable
Insecticide,
Insect
Repellent
Coconut oil8001-31-8#####NA 124N/AOil - vegetable
Coconut oil monoethanolamine68140-00-1691791361Adjuvant,Oil - vegetable
Soap/Surfactant
Corn oil8001-30-7NA 1173626N/AOil - vegetable
Cottonseed oil8001-29-4316021015InsecticideOil - vegetable
Emulsifiable methylatedNA 907NA 1735224Insecticide,Oil - vegetable
vegetable oilAdjuvant
Fir needle oil, siberian8021-29-2NA 2362570N/AOil - vegetable
Hydrogenated castor oil8001-78-3316043830Bird RepellentOil - vegetable
Hydrogenated soybean oil8016-70-4NA 1863670N/AOil - vegetable
Hydrogenated vegetable oilsNA 881NA 1695146N/AOil - vegetable
Linseed oil with driersNA 61NA 1162645N/AOil - vegetable
Linseed oil, boiled68553-15-1NA 1152644N/AOil - vegetable
Methyl soyate68919-53-9NA 1463519AdjuvantOil - vegetable
Oil of linseed8001-26-1316032248N/AOil - vegetable
Olive oil8001-25-0316103710N/AOil - vegetable
Palm oilNA 749NA 1362731N/AOil - vegetable
Peanut oil2227315NA 1183722N/AOil - vegetable
Plant oils (including rape seedNA 1351NA 192NA 191InsecticideOil - vegetable
oil)
Rapeseed oil8002-13-9NA 220NA 219InsecticideOil - vegetable
Safflower oil8001-23-8NA 1241510N/AOil - vegetable
Sesame oil8008-74-0724011221N/AOil - vegetable
Soybean oil8001-22-7316052335Insecticide,Oil - vegetable
Adjuvant
Vegetable oil8008-89-7NA 1111231InsecticideOil - vegetable
Vegetable oil modifiedNA 552NA 1002981N/AOil - vegetable
phenolic resin
Vegetable wax8001-39-6995011441N/AOil - vegetable
Weed oilNA 558NA 1011694N/AOil - vegetable
Wheat germ oilNA 559NA 1012988N/AOil - vegetable
(1R-exo)-Brevicomin20290-99-7#####NA 106PheromonePheromone
(4E-7Z)-4,7-Tridecadien-1-yl-NA 1428NA 199NA 198PheromonePheromone
acetate
(4Z-9Z)-7,9-Dodecadien-1-olNA 1412NA 198NA 197PheromonePheromone
(E)-5-decen-1-ol56578-18-8780385315PheromonePheromone
(E)-10-Dodecenyl acetate35153-09-4NA 187NA 186PheromonePheromone
(E)-11-Tetradecenyl acetate33189-72-9#####5022PheromonePheromone
(E)-2,6-dimethyl-2,6-141-27-5NA 213307PheromonePheromone
octadienal
(E)-4-tridecen-1-yl-acetate72269-48-8#####2199PheromonePheromone
(E)-5-Decenol56578-18-8780383974PheromonePheromone
(E)-5-Decenyl acetate38421-90-8#####3975PheromonePheromone
(E)-6-dodecenyl acetate29868-16-4#####NA 958PheromonePheromone
(E)-9-decen-1-ol56578-18-8780385071PheromonePheromone
(E)-9-dodecen-1-ol, acetate35148-19-7#####2141PheromonePheromone
(E)-9-Tricosene35857-62-6NA 200NA 199PheromonePheromone
(E)7-(Z)9-DodecadienylNA 1413NA 198NA 197PheromonePheromone
acetate
(E,Z)-3,13-octadecadien-1-ol53120-26-6#####NA 955PheromonePheromone
acetate
(E/Z)-8-Dodecenyl acetateNA 1415NA 198NA 197PheromonePheromone
(R,Z)-5-(1-decenyl) dihydro-2-64726-91-6#####2096PheromonePheromone
(3H)-furanone
(Z)-(3,3-26532-24-1#####5081PheromonePheromone
dimethylcyclohexylidene)acetaldehyde
(Z)-11-hexadecen-1-ol56683-54-6#####NA 971PheromonePheromone
(Z)-11-Hexadecen-1-ol56683-54-6NA 193NA 192PheromonePheromone
(Z)-11-hexadecenal53939-28-9#####2126PheromonePheromone
(Z)-11-hexadecenyl acetate60037-58-3#####NA 111PheromonePheromone
(Z)-11-Tetradecen-1-yl-acetate20711-10-8NA 199NA 199PheromonePheromone
(Z)-11-Tetradecenyl acetate20711-10-8#####5023PheromonePheromone
(Z)-13-OctadecanolNA 1423NA 199NA 198PheromonePheromone
(Z)-13-Octadecenal58594-45-9#####NA 111PheromonePheromone
(Z)-13-Octadecenyl acetate34010-21-4#####5316PheromonePheromone
(Z)-2-(3,3-dimethyl cyclo26532-23-0#####5079PheromonePheromone
hexylidene)ethanol
(Z)-3-Methyl-6-isopropenyl--9-NA 1420NA 198NA 198PheromonePheromone
decen-1-yl acetate
(Z)-3-Methyl-6-isopropenyl-NA 1419NA 198NA 198PheromonePheromone
3,4-decadien-1-yl
(Z)-4-tridecen-l-yl-acetate65954-19-0#####2200PheromonePheromone
(Z)-5-Decenyl acetate67446-07-5NA 198NA 197PheromonePheromone
(Z)-5-Dodecen-1-yl acetate16676-96-3NA 187NA 186PheromonePheromone
(Z)-6-dodecenyl acetate16974-12-2#####NA 957PheromonePheromone
(Z)-6-Heneicosane-11-one54844-65-4#####NA 110PheromonePheromone
(Z)-7-hexadecenal56797-40-1#####NA 972PheromonePheromone
(Z)-7-TetradecanolNA 1427NA 199NA 198PheromonePheromone
(Z)-7-Tetradecenal65128-96-3NA 187NA 186PheromonePheromone
(Z)-9-dodecenyl acetate16974-11-1#####2142PheromonePheromone
(Z)-9-hexadecenal56219-04-6#####NA 973PheromonePheromone
(Z)-9-tetradecen-1-ol35153-15-2#####5618PheromonePheromone
(Z)-9-tetradecenal53939-27-8#####2209PheromonePheromone
(Z)-9-Tetradecenyl acetate16725-53-4NA 187NA 186PheromonePheromone
(Z)-9-Tricosene27519-02-4#####NA 883PheromonePheromone
(Z,E) 7,11-hexadecaclien-1-olNA 1144NA 16891997PheromonePheromone
acetate, other related
(Z,E)-7,11-hexadecadien-1-yl51607-94-4#####1997PheromonePheromone
acetate
(Z,E)-7,11-hexadecadien-1-yl53042-79-8#####NA 933PheromonePheromone
acetate
(Z,E)-8,10-dodecadienylNA 1561NA 227NA 227PheromonePheromone
acetate
(Z,E)-9,11-Tetradecadien-1-yl50767-79-8NA 199NA 198PheromonePheromone
acetate
(Z,E)-9,12-tetradecadienyl31654-77-0#####5617PheromonePheromone
acetate
(Z,Z) 7,11-hexadecadien-1-olNA 1145NA 16891998PheromonePheromone
acetate, other related
(Z,Z) Octadienyl acetateNA 1422NA 199NA 198PheromonePheromone
(Z,Z)-11,13-hexadecadienal71317-73-27115314PheromonePheromone
(Z,Z)-3,13-octadecadien-1-ol53120-27-7#####NA 954PheromonePheromone
acetate
(Z,Z)-7,11-hexadecadien-1-yl52207-99-5#####1998PheromonePheromone
acetate
(Z,Z)-7,11-Hexadecadienyl52207-99-5NA 198NA 197PheromonePheromone
acetate
1,7-Dioxaspiro-5,5-undecane180-84-7NA 186NA 186PheromonePheromone
1-Methylbutyl decanoate55195-26-1#####NA 100PheromonePheromone
1-Octen-3-ol3391-86-4690374029Pheromone,Pheromone
Fragrance,
Insect
Repellent, Dog
and Cat
Repellent
11-(E)-Tetradecen-1-ol35153-18-5#####5108PheromonePheromone
11-(Z)-Tetradecen-1-ol34010-15-6#####NA 109PheromonePheromone
2-cyclopenten-1-one, 2-80-71-74049NA 68Pheromone,Pheromone
hydroxy-3-methyl-Fragrance
2-methyl-7(R),8(S)-epoxy29804-22-6#####2165PheromonePheromone
octadecane
3(S)-Methyl-6-isopropenyl-9-NA 1535NA 224NA 224PheromonePheromone
dodecadien-1yl acetate
3,7,11-trimethyl-2,6,10-4601-84-0NA 9832269PheromonePheromone
dodecatriene-1-ol
3-Methyl-2-cyclohexen-1-one1193-18-6#####NA 124InsectPheromone
Repellent,
Pheromone
4-(p-acetoxyphenyl)-2-609379#####NA 106PheromonePheromone
butanone
4-Methyl-3-heptanol14979-39-6#####NA 962PheromonePheromone
7,11-hexadecadien-1-ol, acetate50933-33-0#####NA 934PheromonePheromone
7,8-Epoxi-2-methyl-octadecaneNA 1417NA 198NA 197PheromonePheromone
8-dodecene-1-ol, other relatedNA 1150NA 16892253PheromonePheromone
9-tetradecen-1-ol, formate, (Z)-56218-79-2#####NA 967PheromonePheromone
Acetaldehyde,(3,3-26532-25-2#####5080PheromonePheromone
dimethylcyclohexylidene)-,(E)
beta-Farnesene18794-84-8#####NA 110PheromonePheromone
Cis-11-tetradecenyl acetate20711-10-8#####5038PheromonePheromone
Distilled cubeb oil8007-87-2#####NA 960PheromonePheromone
DodecadienalNA 1547NA 226NA 225PheromonePheromone
E,E-8,10-dodecadien-1-ol33956-49-9#####1851PheromonePheromone
E-3,3-dimethyl-delta,alpha-NA 951NA 3152193PheromonePheromone
cyclohexane ethanal
E-8-dodeceneNA 1532NA 224NA 224PheromonePheromone
E-8-dodecenyl acetate38363-29-0#####2252PheromonePheromone
Farnesol4602-84-0#####2564PheromonePheromone
Frontalin28401-39-0#####NA 985PheromonePheromone
Frontalin + alpha-pinene12701-72-3#####NA 986PheromonePheromone
mixture
German cockroach pheromoneNA 871290285132PheromonePheromone
Isoamyl acetate123-92-2NA 1671422FragrancePheromone
Isomate LBAMNA 1438NA 213NA 212PheromonePheromone
Isomate OFM RossoNA 1426NA 213NA 212PheromonePheromone
Lauryl alcohol112-53-815092343Pheromone,Pheromone,
AdjuvantAlcohol/Ether
Luretape (Grandlure)11104-05-5#####NA 923PheromonePheromone
Methyl-trans-6-nonenoateNA 1421NA 199NA 198PheromonePheromone
Multilure60018-97-5#####NA 963PheromonePheromone
Multistriatin59014-03-8#####NA 961PheromonePheromone
Muscalure27519-02-4#####1858PheromonePheromone
Myrcene123-35-3#####2189PheromonePheromone
Nerolidol7212-44-4#####2268PheromonePheromone
Nerolidol7212-44-4#####2701PheromonePheromone
Pentyl valerate2173-56-0#####1809PheromonePheromone
Periplanone B61228-92-0#####2766PheromonePheromone
PherodimNA 1424NA 199NA 198PheromonePheromone
PronumoneNA 1425NA 199NA 198PheromonePheromone
SerricorninNA 1343NA 191NA 190PheromonePheromone
Tetradecanal124-25-4#####NA 975PheromonePheromone
Trans-11-tetradecenyl acetate33189-72-9#####5039PheromonePheromone
trans-6-Nonen-1-olNA 1404NA 197NA 197PheromonePheromone
Trimedlure12002-53-8#####NA 199PheromonePheromone
Z-2-isopropenyl-1-methyl26532-22-9#####2190PheromonePheromone
cyclobutane ethanol
Z-3,3-dimethyl-delta,alpha-NA 952NA 3162192PheromonePheromone
cyclohexane ethanal
Z-3,3-dimethyl-delta,beta-NA 706NA 1292191PheromonePheromone
cyclohexane ethanol
Z-8-dodeceneNA 1531NA 224NA 224PheromonePheromone
Z-8-dodecenol40642-40-8#####2253PheromonePheromone
Z-8-dodecenyl acetate28079-04-1#####2251PheromonePheromone
7-(diethyl amino)-4-methyl91-44-1NA 3413146RodenticideCoumarin
coumarin
Brodifacoum56073-10-0#####2049RodenticideCoumarin
Bromadiolone28772-56-7#####2135RodenticideCoumarin
Coumachlor81-82-3#####NA 126RodenticideCoumarin
Coumafuryl117-52-286001298RodenticideCoumarin
Coumafuryl, sodium salt34490-93-286004299RodenticideCoumarin
Coumarin91-64-5#####NA 102RodenticideCoumarin
Coumatetralyl5836-29-3#####NA 153RodenticideCoumarin
Difenacoum56073-07-5#####NA 970RodenticideCoumarin
Flocoumafen90035-08-8NA 182NA 181RodenticideCoumarin
Potassium warfarin2610-86-886005NA 836RodenticideCoumarin
PyranocoumarinNA 1431NA 199NA 199RodenticideCoumarin
Warfarin81-81-286002621RodenticideCoumarin
Warfarin, sodium salt129-06-6860031184RodenticideCoumarin
2-isovaleryl 1-1,3-indandione83-28-3677021435Rodenticide1,3-Indandione
2-isovaleryl 1-1,3-indandione,23710-76-1677061736Rodenticide1,3-Indandione
calcium salt
2-isovaleryl-1,3-indandione,53404-57-267709NA 596Rodenticide1,3-Indandione
sodium salt
Chlorophacinone3691-35-8677071625Rodenticide1,3-Indandione
Diphacinone82-66-667701225Rodenticide1,3-Indandione
Diphacinone, sodium salt42721-99-3677051636Rodenticide1,3-Indandione
Pindone83-26-167703489Rodenticide1,3-Indandione
Pindone, calcium salt53404-72-167708NA 595Rodenticide1,3-Indandione
Pindone, sodium salt6120-20-3677041305Rodenticide,1,3-Indandione
Bird Repellent
4-HydroxymethylNA 1173NA 177NA 165Breakdown2,6-Dinitroaniline
pendimethalinproduct
Benfluralin1861-40-18430153Herbicide2,6-Dinitroaniline
Butralin33629-47-9#####1756Herbicide2,6-Dinitroaniline
Dinitramine29091-05-2#####1683Herbicide2,6-Dinitroaniline
Dipropalin5332#####NA 145Herbicide2,6-Dinitroaniline
Ethalfluralin55283-68-6#####2166Herbicide2,6-Dinitroaniline
Fluazinam79622-59-6#####3898Fungicide2,6-Dinitroaniline
Fluchloralin33245-39-5#####1848Herbicide2,6-Dinitroaniline
Flumetralin62924-70-3#####5085Plant Growth2,6-Dinitroaniline
Regulator
Isopropalin33820-53-0#####1681Herbicide2,6-Dinitroaniline
N,N-Bis(2-chloroethyl)-4-26389-78-6#####NA 135N/A2,6-Dinitroaniline
methyl-2,6-dinitroaniline
Nitralin4726-14-137601490Herbicide2,6-Dinitroaniline
Oryzalin19044-88-3#####1868Herbicide2,6-Dinitroaniline
Pendimethalin40487-42-1#####1929Herbicide2,6-Dinitroaniline
Prodiamine29091-21-2#####2236Herbicide2,6-Dinitroaniline
Prodiamine, other relatedNA 1149NA 16892236Herbicide2,6-Dinitroaniline
Profluralin26399-36-0#####1897Herbicide2,6-Dinitroaniline
Profluralin, other relatedNA 1141NA 16791897Herbicide2,6-Dinitroaniline
Trifluralin1582-09-836101597Herbicide2,6-Dinitroaniline
1-(3-51971-67-6#####NA 110N/ACarboxamide
chlorophthalimido)cyclohexane
carboxamide
Allidochlor93-71-019301114HerbicideAmide
Allidochlor202-270-7NA 210NA 210HerbicideAmide
Ammonium benzadox5251-79-698201NA 858HerbicideAmide
Beflubutamid113614-08-7NA 230NA 230HerbicideAmide
Benzadox5251-93-4#####NA 132HerbicideAmide
Benzipram35256-86-1#####NA 133HerbicideAmide
Bromobutide74712-19-9NA 203NA 203HerbicideAmide
Carboxin5234-68-4902011755FungicideCarboxamide
Chlorthiamid1918-13-4#####NA 139HerbicideAmide
Cisanilide34484-77-0#####NA 144HerbicideCarboxamide
Cyclafuramide34849-42-8#####NA 132FungicideCarboxamide
Cyprazole42089-03-2#####NA 132HerbicideAmide
Dimethenamid87674-68-8#####5112HerbicideAmide
Diphenamid957-51-736601226HerbicideAmide
Epronaz59026-08-3NA 231NA 231HerbicideAmide
Etnipromid76120-02-0NA 231NA 231HerbicideAmide
Fenfuram24691-80-3NA 188NA 187FungicideCarboxamide
Fentrazamide158237-07-1NA 232NA 231HerbicideAmide
Flupoxam119126-15-7NA 188NA 188HerbicideAmide
Furmecyclox (Xyligen B)60568-05-0#####NA 18FungicideCarboxamide
Halosafen77227-69-1NA 229NA 229HerbicideAmide, Nitrophenyl
ether
Isocarbamide30979-48-7NA 183NA 182HerbicideAmide
Isoxaben82558-50-7#####2289HerbicideAmide
Methfuroxam28730-17-8#####NA 949FungicideCarboxamide
Metsulfovax21452-18-6NA 189NA 188FungicideCarboxamide
Napropamide15299-99-7#####1728HerbicideAmide
Naptalam132-66-1307022998HerbicideAmide
Naptalam, sodium salt132-67-230703437HerbicideAmide
Nitrofurazone (not subject to59-87-0#####NA 128N/ACarboxamide
FIFRA: 8709-e pm 24)
Oxycarboxin5259-88-1902021434FungicideCarboxamide
p-Benzoquinone61566-21-0#####NA 133N/ACarboxamide
semicarbazone
Pethoxamid106700-29-2NA 233NA 233HerbicideAmide
Propyzamide23950-58-5#####694HerbicideAmide
Propyzamide metaboliteNA 1048NA 1554093BreakdownAmide
product
Quinonamid27541-88-4NA 210NA 209HerbicideAmide
2-Hydroxy alachlorNA 943NA 1832602BreakdownChloroacetanilide
product
3,4,5-tribromo salicylanilide,NA 1122NA 16590833MicrobiocideAnilide
other related
3,5-dibromosalicylanilide2577-72-2774051256MicrobiocideAnilide
5,4-dibromosalicylanilideNA 1024NA 1221071MicrobiocideAnilide
Aatram (propachlor with8070-76-680816NA 781HerbicideTriazine,
atrazine) (019101 + 080803)Chloroacetanilide
Acetochlor34256-82-1#####2349HerbicideChloroacetanilide
Alachlor15972-60-890501678HerbicideChloroacetanilide
Benodanil15310-01-7#####NA 154FungicideAnilide
Butachlor23184-66-9#####4056HerbicideChloroacetanilide
Butenachlor87310-56-3NA 206NA 206HerbicideChloroacetanilide
Clomeprop84496-56-0NA 204NA 203HerbicideAnilide
Cyprofuram69581-33-5NA 186NA 185FungicideAnilide
Cypromid2759-71-926101178HerbicideAnilide
Delachlor24353-58-0#####NA 132HerbicideChloroacetanilide
Diethatyl-ethyl38727-55-8#####1995HerbicideChloroacetanilide
Diflufenican83164-33-4NA 184NA 183HerbicideAnilide
Dimethachlor50563-36-5NA 184NA 183HerbicideChloroacetanilide
Etobenzanid79540-50-4NA 229NA 228HerbicideAnilide
Fenasulam78357-48-9NA 231NA 231HerbicideAnilide
Flufenacet142459-58-3#####5293HerbicideAnilide
FlufenicanNA 1568NA 234NA 234HerbicideAnilide
Flutolanil66332-96-5#####2305FungicideAnilide
Mefenacet73250-68-7NA 189NA 188HerbicideAnilide
Mefluidide53780-34-0#####5082Herbicide,Anilide
Plant Growth
Regulator
Mefluidide, diethanolamine salt53780-36-2#####1955HerbicideAnilide
Mefluidide, potassium salt83601-83-6#####5083HerbicideAnilide
Mepronil55814-41-0NA 189NA 188FungicideAnilide
Metazachlor67129-08-2NA 184NA 183HerbicideChloroacetanilide
Metolachlor51218-45-2#####1996HerbicideChloroacetanilide
Metolachlor, (S)87392-12-9#####5133HerbicideChloroacetanilide
Monalide7287-36-7#####NA 134HerbicideAnilide
Naproanilide52570-16-8NA 233NA 232HerbicideAnilide
Ofurace58810-48-3NA 189NA 188FungicideAnilide
Oxadixyl77732-09-3#####3539FungicideAnilide
Perfluidone37924-13-3#####1895HerbicideAnilide
Perfluidone, diethanolamineNA 991NA 6711896HerbicideAnilide
salt
Pretilachlor51218-49-6NA 184NA 184HerbicideChloroacetanilide
Propachlor1918-16-719101511HerbicideChloroacetanilide
Propanil709-98-828201503HerbicideAnilide
Propisochlor86763-47-5NA 233NA 233HerbicideChloroacetanilide
Prynachlor21267-72-1#####NA 138Herbicide,Chloroacetanilide
Plant Growth
Regulator
Pyracarbolid24691-76-7NA 210NA 209FungicideAnilide
Salicylanilide87-17-277407450Fungicide,Anilide
Microbiocide
Sodium salicylanilide251930#####NA 145FungicideAnilide
Thenylchlor96491-05-3NA 229NA 229HerbicideChloroacetanilide
Triclocarban101-20-227901844N/AAnilide
Benzoylprop22212-56-2NA 182NA 181HerbicideArylalanine
Benzoylprop ethyl22212-55-1#####NA 147HerbicideArylalanine
Benzoylprop-ethyl33878-50-1NA 206NA 205HerbicideArylalanine
Flamprop58667-63-3NA 188NA 187HerbicideArylalanine
Flamprop-isopropyl52756-22-6#####NA 154HerbicideArylalanine
Flamprop-M-isopropyl57973-67-8#####NA 154HerbicideArylalanine
Flamprop-M-methyl57973-66-7#####NA 104HerbicideArylalanine
Flamprop-methyl52756-25-9#####NA 154HerbicideArylalanine
Chlorazifop60074-25-1NA 231NA 230HerbicideAryloxyphenoxy
propionic acid
Clodinafop114420-56-3NA 182NA 182Plant GrowthAryloxyphenoxy
Regulatorpropionic acid
Clodinafop-propargyl105512-06-9#####NA 163Plant GrowthAryloxyphenoxy
Regulatorpropionic acid
Clofop26129-32-8NA 207NA 206HerbicideAryloxyphenoxy
propionic acid
Cyhalofop122008-78-0NA 204NA 203HerbicideAryloxyphenoxy
propionic acid
Cyhalofop butyl122008-85-9NA 2155748HerbicideAryloxyphenoxy
propionic acid
Diclofop40843-25-2#####NA 912HerbicideAryloxyphenoxy
propionic acid
Diclofop-methyl51338-27-3#####2034HerbicideAryloxyphenoxy
propionic acid
Fenoxaprop-ethyl82110-72-3NA 201NA 200HerbicideAryloxyphenoxy
(stereochemistry unspecified)propionic acid
Fenoxaprop-P (+)71283-80-2#####5123HerbicideAryloxyphenoxy
propionic acid
Fenoxaprop-P (+/−)66441-23-4#####2311HerbicideAryloxyphenoxy
propionic acid
Fenoxaprop-P-ethyl113158-40-0NA 220NA 219HerbicideAryloxyphenoxy
propionic acid
Fenthiaprop (racemic)95721-12-3NA 207NA 207HerbicideAryloxyphenoxy
propionic acid
Fenthiaprop (unstated73519-50-3NA 218NA 217HerbicideAryloxyphenoxy
stereochemistry)propionic acid
Fenthiaprop-ethyl (racemic)93921-16-5NA 218NA 217HerbicideAryloxyphenoxy
propionic acid
Fenthiaprop-ethyl (unstated66441-11-0NA 218NA 217HerbicideAryloxyphenoxy
stereochemistry)propionic acid
Fluazifop69335-91-7NA 194NA 193HerbicideAryloxyphenoxy
propionic acid
Fluazifop-butyl69806-50-4#####2186HerbicideAryloxyphenoxy
propionic acid
Fluazifop-P-butyl79241-46-6#####NA 995HerbicideAryloxyphenoxy
propionic acid
Fluazifop-P-butyl83066-88-0NA 228NA 228HerbicideAryloxyphenoxy
propionic acid
Haloxyfop (unstated69806-34-4#####NA 100HerbicideAryloxyphenoxy
stereochemistry)propionic acid
Haloxyfop-etotyl (unstated87237-48-7NA 200NA 199HerbicideAryloxyphenoxy
stereochemistry)propionic acid,
Glycol Ether
Haloxyfop-methyl (unstated690806-40-2#####NA 19HerbicideAryloxyphenoxy
stereochemistry)propionic acid
Haloxyfop-R72619-32-0NA 191NA 190HerbicideAryloxyphenoxy
propionic acid
Propaquizafop111479-05-1NA 185NA 184HerbicideAryloxyphenoxy
propionic acid
Quizalofop76578-12-6NA 190NA 189HerbicideAryloxyphenoxy
propionic acid
Quizalofop-ethyl76578-14-8#####2226HerbicideAryloxyphenoxy
propionic acid
Quizalofop-P94051-08-8NA 185NA 184HerbicideAryloxyphenoxy
propionic acid
Quizalofop-P-ethyl100646-51-3NA 212NA 211HerbicideAryloxyphenoxy
propionic acid
Quizalofop-p-tefuryl119738-06-6NA 202NA 202HerbicideAryloxyphenoxy
propionic acid
Trifop58594-744NA 234NA 233HerbicideAryloxyphenoxy
propionic acid
2,5-Dichlorobenzoic acid50-79-3NA 224NA 224FungicideBenzoic acid
2,5-Dichlorobenzoic acid2905-69-3NA 224NA 224FungicideBenzoic acid
methyl ester
3,5-dichlorobenzoic acid51-36-5NA 1564066N/ABenzoic acid
4′-hydroxy-m-phenoxy benzoic35065-12-4NA 1762609Fungicide,Benzoic acid
acidMicrobiocide
4-hydroxy benzoic acid99-96-7NA 200NA 199N/ABenzoic acid
5-hydroxy-dicambaNA 840NA 1564065Herbicide,Benzoic acid
Breakdown
product
Butyl paraben94-26-861205NA 496Fungicide,Benzoic acid
Microbiocide
Chloramben133-90-4299012184HerbicideBenzoic acid
Chloramben, ammonium salt1076-46-629902831HerbicideBenzoic acid
Chloramben, ammonium salt,NA 1121NA 16590831HerbicideBenzoic acid
other related
Dicamba1918-00-929801200HerbicideBenzoic acid
Dicamba with 2,4-D8068-77-729807NA 219HerbicideBenzoic acid
Dicamba with 2,4-D & Silvex8073-53-829808NA 220HerbicideBenzoic acid
Dicamba, aluminium saltNA 1215#####NA 170HerbicideBenzoic acid
Dicamba, butoxyethyl esterNA 1477NA 220NA 219HerbicideBenzoic acid
Dicamba, diethanolamine salt25059-78-329803780HerbicideBenzoic acid
Dicamba, diglycolamine salt104040-79-1#####5007HerbicideBenzoic acid
Dicamba, dimethylamine salt2300-66-529802849HerbicideBenzoic acid
Dicamba, dimethylamine salt,NA 1123NA 16590849HerbicideBenzoic acid
other related
Dicamba, isopropylamine salt55871-02-8#####5098HerbicideBenzoic acid
Dicamba, methyl ester6597-78-0#####NA 146HerbicideBenzoic acid
Dicamba, monoethanolamine53404-28-7298041829HerbicideBenzoic acid
salt
Dicamba, monoethanolamineNA 1140NA 16791829HerbicideBenzoic acid
salt, other related
Dicamba, other relatedNA 1084NA 16190200HerbicideBenzoic acid
Dicamba, potassium salt10007-85-9#####5110HerbicideBenzoic acid
Dicamba, sodium salt1982-69-0298065057HerbicideBenzoic acid
Dicamba, triethanolamine salt53404-29-8298051113HerbicideBenzoic acid
Dichlorobenzoic acidNA 1383NA 195NA 194FungicideBenzoic acid
methylester
Diethanolamine 3-amino-2,5-53404-16-329904NA 222HerbicideBenzoic acid
dichlorobenzoate
Dodecylamine salicylate7491-21-6393022003Insecticide,Benzoic acid
Fungicide,
Microbiocide
Ethyl paraben120-47-8612023204Fungicide,Benzoic acid
Microbiocide
Homosalate118-56-9766033231Insecticide,Benzoic acid
Fungicide,
Microbiocide
Methyl chloramben7286-84-229905NA 223HerbicideBenzoic acid
Methyl paraben99-76-3612011005Fungicide,Benzoic acid
Microbiocide
Methyl paraben, calcium salt40167-95-161208NA 499Fungicide,Benzoic acid
Microbiocide
Methyl paraben, sodium salt5026-62-061207NA 498Fungicide,Benzoic acid
Microbiocide
Monomethylammonium25182-03-029903NA 221HerbicideBenzoic acid
chloramben (3-amino-2,5-
dichlorobenzoic acid)
Propyl paraben94-13-3612032841Fungicide,Benzoic acid
Microbiocide
Propyl paraben, calcium salt83542-69-261206NA 497Fungicide,Benzoic acid
Microbiocide
Propyl paraben, sodium salt35285-69-961204NA 495Fungicide,Benzoic acid
Microbiocide
Salicylic acid69-72-7766021170Insecticide,Benzoic acid
Fungicide,
Microbiocide
Sodium 3-amino-2,5-1954-81-029906NA 224HerbicideBenzoic acid
dichlorobenzoate
Tricamba2307-49-517301NA 151HerbicideBenzoic acid
Anisuron2689-43-2#####NA 138HerbicideBenzoylurea
Diflubenzuron35367-38-5#####1992InsecticideBenzoylurea
Flucycloxuron113036-88-7#####NA 109HerbicideBenzoylurea
Flucycloxuron, (E)94050-52-9NA 201NA 200HerbicideBenzoylurea
Flufenoxuron101463-69-8#####NA 901InsecticideBenzoylurea
Hexaflumuron86479-06-3#####3899InsecticideBenzoylurea
Lufenuron103055-07-8NA 184NA 183InsecticideBenzoylurea
Novaluron116714-46-6NA 226NA 226HerbicideBenzoylurea
Phenobenzuron449583#####NA 133HerbicideBenzoylurea
Teflubenzuron83121-18-0#####NA 33InsecticideBenzoylurea
Triflumuron64628-44-0#####2961InsecticideBenzoylurea
Diethamquat chlorideNA 1567NA 231NA 231HerbicideBipyridylium
Diquat bistribromide27041-82-3#####NA 146HerbicideBipyridylium
Diquat dibromide85-00-732201229Herbicide,Bipyridylium
Dessicant
Diquat ion2764-72-932202NA 294N/ABipyridylium
Monolinuron with paraquat69312-67-0#####NA 119HerbicideUrea, Bipyridylium
dichloride
Morfamquat7411-47-4#####NA 135N/ABipyridylium
Morfamquat7411-47-4NA 201NA 200HerbicideBipyridylium
Morfamquat chloride4636-83-3NA 212NA 212HerbicideBipyridylium
Paraquat4685-14-761603NA 500HerbicideBipyridylium
Paraquat bis(methylsulfate)2074-50-261602458HerbicideBipyridylium
Paraquat bistribromide27041-84-5#####NA 159HerbicideBipyridylium
Paraquat dichloride1910-42-5616011601HerbicideBipyridylium
Priglone (diquat dibromide78403-23-332203NA 295N/ABipyridylium
w/paraquat ion)
1,3-Dimethyl-1,1,3,3-22232-20-834601NA 303N/ABis-Carbamate
disiloxanetetrol-1,3-
bis(dimethylthiocarbamate)
Desmedipham13684-56-5#####1748HerbicideBis-Carbamate
Dimethyl (4-methyl-1,3-51543-98-7#####NA 888FungicideBis-Carbamate
phenylenebis(iminocarbonyl-
1H-benzimidazole-1,2-
diyl))biscarbamate
Phenisopham57375-63-0NA 209NA 208HerbicideBis-Carbamate
Phenmedipham13684-63-498701675HerbicideBis-Carbamate
Phenmedipham-ethyl13684-44-1#####NA 149HerbicideBis-Carbamate
2-Hydroxy alachlorNA 943NA 1832602BreakdownChloroacetanilide
product
Aatram (propachlor with8070-76-680816NA 781HerbicideTriazine,
atrazine) (019101 + 080803)Chloroacetanilide
Acetochlor34256-82-1#####2349HerbicideChloroacetanilide
Alachlor15972-60-890501678HerbicideChloroacetanilide
Butachlor23184-66-9#####4056HerbicideChloroacetanilide
Butenachlor87310-56-3NA 206NA 206HerbicideChloroacetanilide
Delachlor24353-58-0#####NA 132HerbicideChloroacetanilide
Diethatyl-ethyl38727-55-8#####1995HerbicideChloroacetanilide
Dimethachlor50563-36-5NA 184NA 183HerbicideChloroacetanilide
Metazachlor67129-08-2NA 184NA 183HerbicideChloroacetanilide
Metolachlor51218-45-2#####1996HerbicideChloroacetanilide
Metolachlor, (S)87392-12-9#####5133HerbicideChloroacetanilide
Pretilachlor51218-49-6NA 184NA 184HerbicideChloroacetanilide
Propachlor1918-16-719101511HerbicideChloroacetanilide
Propisochlor86763-47-5NA 233NA 233HerbicideChloroacetanilide
Prynachlor21267-72-1#####NA 138Herbicide,Chloroacetanilide
Plant Growth
Regulator
Thenylchlor96491-05-3NA 229NA 229HerbicideChloroacetanilide
(2-Methyl-4,6-13333-87-4#####NA 161ImpurityChlorophenoxy acid
dichlorophenoxy)acetic acidor ester
(as impurity)
2,3,6-Trichlorophenylacetic2903-64-282603NA 819HerbicideChlorophenoxy acid
acidor ester
2,3,6-Trichlorophenylacetic53404-91-482604NA 820HerbicideChlorophenoxy acid
acid, sodium saltor ester
2,4,5-T93-76-582001639HerbicideChlorophenoxy acid
or ester
2,4,5-T tetradecylamine salt53535-37-8820131989HerbicideChlorophenoxy acid
or ester
2,4,5-T, 2-ethylhexyl ester1928-47-8820631092HerbicideChlorophenoxy acid
or ester
2,4,5-T, alkylamine salt53535-37-882013818HerbicideChlorophenoxy acid
or ester
2,4,5-T, butoxyethanol ester2545-59-782053819HerbicideChlorophenoxy acid
or ester, Glycol Ether
2,4,5-T, butoxyethanol ester2545-59-782072NA 166HerbicideChlorophenoxy acid
or ester
2,4,5-T, butoxypropyl ester1928-48-982055820HerbicideChlorophenoxy acid
or ester
2,4,5-T, butyl ester93-79-882056822HerbicideChlorophenoxy acid
or ester
2,4,5-T, butyric acid93-80-1#####NA 152HerbicideChlorophenoxy acid
or ester
2,4,5-T, dimethylamine salt6369-97-7820191474HerbicideChlorophenoxy acid
or ester
2,4,5-T, dodecylamine salt53404-84-5820111988HerbicideChlorophenoxy acid
or ester
2,4,5-T, isooctyl ester25168-15-4NA 121851HerbicideChlorophenoxy acid
or ester
2,4,5-T, N-oleyl-1,3-53404-87-8820291097HerbicideChlorophenoxy acid
propylenediamine saltor ester
2,4,5-T, propylene glycol butyl1928-48-982055824HerbicideChlorophenoxy acid
ether esteror ester
2,4,5-T, triethylamine salt2008-46-082034850HerbicideChlorophenoxy acid
or ester
2,4,5-trichlorophenoxyacetic69462-12-082064NA 799HerbicideChlorophenoxy acid
acid, 2-ethyl-4-methylpentylor ester
ester
2,4,5-trichlorophenoxyacetic53404-85-682012NA 790HerbicideChlorophenoxy acid
acid, alkyl(C13) amine saltor ester
2,4,5-trichlorophenoxyacetic120-39-882051NA 795HerbicideChlorophenoxy acid
acid, amyl esteror ester
2,4,5-trichlorophenoxyacetic1928-58-182052NA 796HerbicideChlorophenoxy acid
acid, butoxyethoxypropanolor ester
ester
2,4,5-trichlorophenoxyacetic53404-86-782038NA 793HerbicideChlorophenoxy acid
acid, diethylethanolamine saltor ester
2,4,5-trichlorophenoxyacetic4938-72-182062NA 798HerbicideChlorophenoxy acid
acid, isobutyl esteror ester
2,4,5-trichlorophenoxyacetic93-78-782066NA 800HerbicideChlorophenoxy acid
acid, isopropyl esteror ester
2,4,5-trichlorophenoxyacetic55256-33-282039NA 794HerbicideChlorophenoxy acid
acid, N,N-dimethyl oleyl-or ester
linoleyl amine salt
2,4,5-trichlorophenoxyacetic53404-88-982037NA 792HerbicideChlorophenoxy acid
acid, N,N-or ester
dimethyllinoleylamine salt
2,4,5-trichlorophenoxyacetic53404-89-082020NA 791HerbicideChlorophenoxy acid
acid, N,N-dimethyloleylamineor ester
salt
2,4,5-trichlorophenoxyacetic55491-33-382077NA 803HerbicideChlorophenoxy acid
acid, pentyl esteror ester
2,4,5-trichlorophenoxyacetic13560-99-182004NA 789HerbicideChlorophenoxy acid
acid, sodium saltor ester
2,4,5-trichlorophenoxyacetic53535-32-382075NA 802HerbicideChlorophenoxy acid
acid, tripropylene glycolor ester
isobutyl ether ester
2,4-D94-75-730001636Herbicide,Chlorophenoxy acid
Plant Growthor ester
Regulator
2,4-D with 2,4,5-T8015-35-830077NA 259HerbicideChlorophenoxy acid
or ester
2,4-D, 2-ethyl-4-methylpentyl53404-37-8NA 227NA 227HerbicideChlorophenoxy acid
esteror ester
2,4-D, 2-ethylhexyl ester1928-43-4300631622HerbicideChlorophenoxy acid
or ester
2,4-D, alkanolamine salts2307-55-330005801HerbicideChlorophenoxy acid
(ethanol and isopropanolor ester
amines)
2,4-D, alkyl (C12) amine salts2212-54-630011980HerbicideChlorophenoxy acid
or ester
2,4-D, alkyl (C14) amine salts28685-18-930013981HerbicideChlorophenoxy acid
or ester
2,4-D, butoxy ethoxy propanol1928-57-0300521255HerbicideChlorophenoxy acid
esteror ester
2,4-D, butoxyethanol ester1929-73-330053802HerbicideChlorophenoxy acid
or ester, Glycol Ether
2,4-D, butoxyethanol ester1929-73-330061NA 166HerbicideChlorophenoxy acid
or ester
2,4-D, butoxypropyl ester1928-45-630055803HerbicideChlorophenoxy acid
or ester
2,4-D, butyl ester94-80-430056804HerbicideChlorophenoxy acid
or ester
2,4-D, chlorocrotyl ester2971-38-2NA 228NA 227HerbicideChlorophenoxy acid
or ester
2,4-D, diethanolamine salt5742-19-830016805HerbicideChlorophenoxy acid
or ester
2,4-D, diethylamine salt20940-37-830017875HerbicideChlorophenoxy acid
or ester
2,4-D, dimethylamine salt2008-39-130019806HerbicideChlorophenoxy acid
or ester
2,4-D, dodecylamine salt2212-54-630011807HerbicideChlorophenoxy acid
or ester
2,4-D, heptylamine salt37102-63-9300231962HerbicideChlorophenoxy acid
or ester
2,4-D, isooctyl ester25168-26-730064809HerbicideChlorophenoxy acid
or ester
Triclopyr55335-06-3#####NA 36HerbicideChloropyridinyl
Triclopyr ethyl ester60825-27-6#####NA 108HerbicideChloropyridinyl
Triclopyr, butoxyethyl ester64700-56-7#####2170HerbicideChloropyridinyl,
Glycol Ether
Triclopyr, triethylamine salt57213-69-1#####2131HerbicideChloropyridinyl
Alloxydim55634-91-8NA 203NA 203HerbicideCyclohexenone
derivative
Alloxydim sodium55635-13-7#####NA 926HerbicideCyclohexenone
derivative
Butroxydim138164-12-2NA 202NA 202HerbicideCyclohexenone
derivative
Clethodim99129-21-2#####3566HerbicideCyclohexenone
derivative
Cloproxydim95480-33-4NA 231NA 231HerbicideCyclohexenone
derivative
Cycloxydim101205-02-1NA 184NA 183HerbicideCyclohexenone
derivative
Sethoxydim74051-80-2#####2177HerbicideCyclohexenone
derivative
Tepraloxydim149979-41-9#####NA 982HerbicideCyclohexenone
derivative
Tralkoxydim87820-88-0#####5457HerbicideCyclohexenone
derivative
2,4-dinitrophenol51-28-537509221ImpurityDinitrophenol
derivative
2,4-dinitrophenol, sodium salt1011-73-0#####NA 161Impurity,Dinitrophenol
(as impurity)Breakdownderivative
product
2,4-Dinitrophenyl thiocyanate1594-56-5#####NA 146N/ADinitrophenol
derivative
2,6-dinitrophenol, sodium salt32581-06-9#####NA 161ImpurityDinitrophenol
(as impurity)derivative
2-Cyclohexyl-4,6-dinitrophenol317-83-937502NA 316N/ADinitrophenol
dicyclohexylaminederivative
3,3′-Dichloro-5,5′-dinitro-(1,1′-15595-24-1#####NA 137N/ADinitrophenol
biphenyl)-2,2′-diolderivative
3,3′-Dichloro-5,5′-dinitro-(1,1′-63992-31-4#####NA 137N/ADinitrophenol
biphenyl)-2,2′-diolderivative
4,6-Dinitro-2-69632-97-9#####NA 145N/ADinitrophenol
cyclohexylphenol, 2-((2-derivative
aminoethyl)amino)ethanol salt
4,6-Dinitro-2-69632-98-0#####NA 145N/ADinitrophenol
cyclohexylphenol,derivative
triethanolamine salt
5,5′-Dichloro-3,3′-dinitro-(1,1′-10331-57-4#####NA 137N/ADinitrophenol
biphenyl)-2,2′-diolderivative
6,6′-Dichloro-4,4′-dinitro-(1,1′-21832-25-7#####NA 137N/ADinitrophenol
biphenyl)-2,2′-diolderivative
Binapacryl485-31-41220173HerbicideDinitrophenol
derivative
Diethanolamine dinoseb (2-53404-43-637514NA 320HerbicideDinitrophenol
sec-butyl-4,6-dinitrophenol)derivative
Dinex131-89-537501NA 315N/ADinitrophenol
derivative
Dinitro cresol534-52-1375073170FungicideDinitrophenol
derivative
Dinitro-1-methyl heptyl phenolNA 159NA 302758N/ADinitrophenol
derivative
Dinitrophenol (mixed isomers)25550-58-7NA 223NA 223BreakdownDinitrophenol
product,derivative
Impurity
Dinobuton973-21-7#####2526Insecticide,Dinitrophenol
Fungicidederivative
Dinocap39300-45-336001344Fungicide,Dinitrophenol
Insecticidederivative
Dinocap, other relatedNA 1091NA 16290344Insecticide,Dinitrophenol
Fungicidederivative
Dinocton32534-96-6NA 207NA 206Insecticide,Dinitrophenol
Fungicidederivative
Dinofenate61614-62-8#####NA 146HerbicideDinitrophenol
derivative
Dinopenton5386-57-2#####NA 154N/ADinitrophenol
derivative
Dinoprop7257-41-2#####NA 138N/ADinitrophenol
derivative
Dinosam4097-36-337504NA 318N/ADinitrophenol
derivative
Dinoseb88-85-737505238Herbicide,Dinitrophenol
Defoliantderivative
Dinoseb acetate2813-95-8NA 207NA 206HerbicideDinitrophenol
derivative
Dinoseb, amine salt224438737511239Herbicide,Dinitrophenol
Defoliantderivative
Dinoseb, ammonium salt6365-83-937513240Herbicide,Dinitrophenol
Defoliantderivative
Dinoseb, sodium salt35040-03-0375121445Herbicide,Dinitrophenol
Defoliantderivative
Dinoseb, triethanolamine salt6420-47-937506235Herbicide,Dinitrophenol
Defoliantderivative
Dinosulfon5386-77-6#####NA 157N/ADinitrophenol
derivative
Dinoterb1420-07-1#####NA 128HerbicideDinitrophenol
derivative
Dinoterbon6073-72-9#####NA 128HerbicideDinitrophenol
derivative
DNOC, sodium salt2312-76-737508533Fungicide,Dinitrophenol
Microbiocide,derivative
Insecticide,
Herbicide
Etinofen2544-94-7#####NA 147N/ADinitrophenol
derivative
Medinoterb acetate212943NA 208NA 208HerbicideDinitrophenol
derivative
Methyl 2-(1-methylheptyl)-4,6-5386-68-5#####NA 157N/ADinitrophenol
dinitrophenyl carbonatederivative
Premerge plus (naptalam with8075-57-830704NA 278HerbicideDinitrophenol
dinoseb)derivative
Sodium naptalam with sodium59915-53-630705NA 279HerbicideDinitrophenol
dinosebderivative
Sultropen963-22-4#####NA 146N/ADinitrophenol
derivative
Acifluorfen50594-66-6#####NA 935HerbicideDiphenyl ether
Acifluorfen, sodium salt62476-59-9#####2218HerbicideDiphenyl ether
Aclonifen74070-46-5NA 187NA 187HerbicideDiphenyl ether
Bifenox42576-02-3#####1953HerbicideDiphenyl ether
Chlomethoxyfen32861-85-1NA 185NA 185HerbicideDiphenyl ether
Diofenolan63837-33-27703NA 101HerbicideDiphenyl ether
Ethyl acifluorfen77207-01-3#####NA 936HerbicideDiphenyl ether
Fluoroglycofen77501-60-1NA 181NA 180HerbicideDiphenyl ether
Fomesafen72178-02-0#####NA 17HerbicideDiphenyl ether
Fomesafen sodium108731-70-0#####5086HerbicideDiphenyl ether
Lactofen77501-63-4#####3538HerbicideDiphenyl ether
Methyl acifluorfen50594-67-7#####NA 937HerbicideDiphenyl ether
Oxyfluorfen42874-03-3#####1973HerbicideDiphenyl ether
Bromobonil25671-46-9#####NA 134HerbicideHydroxybenzonitrile
Bromoxynil butyrate3861-41-4353032163HerbicideHydroxybenzonitrile
Bromoxynil heptanoate56634-95-8#####5036HerbicideHydroxybenzonitrile
Bromoxynil octanoate1689-99-235302834HerbicideHydroxybenzonitrile
Bromoxynil pentanoateNA 1476NA 220NA 219HerbicideHydroxybenzonitrile
Bromoxynil phenol1689-84-5353012429HerbicideHydroxybenzonitrile
Chloroxynil1891-95-8#####NA 138HerbicideHydroxybenzonitrile
Ioxynil1689-83-4#####2616HerbicideHydroxybenzonitrile
Ioxynil lithium2961-61-7#####NA 141HerbicideHydroxybenzonitrile
Ioxynil octanoate3861-47-0#####NA 141HerbicideHydroxybenzonitrile
Ioxynil sodium2961-62-8#####NA 141HerbicideHydroxybenzonitrile
3-5-(1,1-Dimethylethyl)-3-78327-32-9#####NA 108AlgaecideImidazolinone
isoxazolyl-4-hydroxy-1-
methyl-2-imidazolidinone
3-Pyridinecarboxylic acid, 2-81334-60-3#####NA 1HerbicideImidazolinone
(4,5-dihydro-4-methyl-4-(1-
methylethyl)-5-oxo-1H-
imidazol-2-yl)-5-methyl-, (.+−.)-
Imazamethabenz81405-85-8#####2240HerbicideImidazolinone
Imazamox114311-32-9#####NA 2HerbicideImidazolinone
Imazapic104098-48-8NA 212NA 211HerbicideImidazolinone
Imazapyr81334-34-1#####2256HerbicideImidazolinone
Imazapyr, isopropylamine salt81510-83-0#####2257HerbicideImidazolinone
Imazaquin81335-37-7#####2613Herbicide,Imidazolinone
Plant Growth
Regulator
Imazaquin, ammonium salt81335-47-9#####3006HerbicideImidazolinone
Imazaquin, sodium salt81335-46-8#####5109HerbicideImidazolinone
Imazethapyr81335-77-5#####2340Herbicide,Imidazolinone
Plant Growth
Regulator
Imazethapyr, ammonium salt101917-66-2#####2341HerbicideImidazolinone
Pyridine carboxylic acid, 2-104098-49-9#####5097HerbicideImidazolinone
(4,5-dihydro-4-methyl-4-(1-
methylethyl)-5-oxo-1H-
imidazol-2-yl)-5-methyl,
monoammonium salt
Chloreturon20782-58-5NA 231NA 230HerbicidePhenylurea
Daimuron42609-52-9NA 204NA 204HerbicidePhenylurea
Fluothiuron33439-45-1NA 232NA 232HerbicidePhenylurea
Methyldymron42609-73-4NA 205NA 204HerbicidePhenylurea
Tetrafluoron27954-37-6#####NA 145HerbicidePhenylurea
Bilanafos71048-99-2NA 202NA 201HerbicidePhosphinico amino
acid
Ampropylofos16606-64-7NA 181NA 180FungicidePhosphonic acid
Glyphosate1071-83-6#####2997HerbicidePhosphonoglycine
Glyphosate, ammonium salt114370-14-8NA 2282319HerbicidePhosphonoglycine
Glyphosate, diammonium saltNA 1566NA 2295810HerbicidePhosphonoglycine
Glyphosate, isopropylamine38641-94-0#####1855HerbicidePhosphonoglycine
salt
Glyphosate, monoammonium114370-14-8#####2301HerbicidePhosphonoglycine
salt
Glyphosate, sodium sesqui salt70393-85-0#####2275HerbicidePhosphonoglycine
Glyphosate-trimesium81591-81-3#####2327HerbicidePhosphonoglycine
N,N-2439-99-8#####NA 884HerbicidePhosphonoglycine
Bis(phosphonomethyl)glycine
6-chloropicolinic acid4684-94-069206NA 657HerbicidePyridinecarboxylic
acid
Clopyralid1702-17-6#####5135HerbicidePyridinecarboxylic
acid
Clopyralid copperNA 1458NA 216NA 216HerbicidePyridinecarboxylic
acid
Clopyralid, monoethanolamine57754-85-5#####5050HerbicidePyridinecarboxylic
saltacid
Clopyralid, triethylamine saltNA 955#####2339HerbicidePyridinecarboxylic
acid
Picloram51455101593HerbicidePyridinecarboxylic
acid
Picloram, alkanolamine saltNA 1479NA 220NA 219HerbicidePyridinecarboxylic
acid
Picloram, diethanolamine salt5145NA 220NA 220HerbicidePyridinecarboxylic
acid
Picloram, isooctyl ester26952-20-55103835HerbicidePyridinecarboxylic
acid
Picloram, potassium salt2545-60-051045330HerbicidePyridinecarboxylic
acid
Picloram, triethylamine salt35832-11-25105NA 77HerbicidePyridinecarboxylic
acid
Picloram, triisopropanolamine6753-47-551021099HerbicidePyridinecarboxylic
saltacid
Picolinafen137641-05-5NA 210NA 210HerbicidePyridinecarboxylic
acid
Thiazopyr117718-60-2#####3984HerbicidePyridinecarboxylic
acid
Amidosulfuron120923-37-7NA 183NA 183HerbicideSulfonylurea
Azimsulfuron120162-55-2#####NA 112HerbicideSulfonylurea
Bensulfuron99283-01-9NA 181NA 180HerbicideSulfonylurea
Bensulfuron methyl83055-99-6#####2263HerbicideSulfonylurea
Chlorimuron99283-00-8NA 204NA 203HerbicideSulfonylurea
Chlorimuron ethyl90982-32-4#####2458HerbicideSulfonylurea
Chlorsulfuron64902-72-3#####2143HerbicideSulfonylurea
Cinosulfuron94593-91-6NA 183NA 183HerbicideSulfonylurea
Cyclosulfamuron136849-15-5NA 204NA 203HerbicideSulfonylurea
Ethametsulfuron111353-84-5NA 212NA 212HerbicideSulfonylurea
Ethametsulfuron-methyl97780-06-8#####NA 43HerbicideSulfonylurea
Ethoxysulfuron126801-58-9NA 226NA 225HerbicideSulfonylurea
Flazasulfuron104040-78-0NA 229NA 228HerbicideSulfonylurea
Flupyrsulfuron150315-10-9NA 205NA 204HerbicideSulfonylurea
Flupyrsulfuron-methylNA 1460NA 216NA 216HerbicideSulfonylurea
Flupyrsulfuron-methyl, sodium144740-54-5NA 218NA 217HerbicideSulfonylurea
salt
Halosulfuron100784-20-1#####3919HerbicideSulfonylurea
Imazosulfuron122548-33-8NA 229NA 229HerbicideSulfonylurea
Iodosulfuron methyl185119-76-0NA 212NA 211HerbicideSulfonylurea
Iodosulfuron methyl, sodium144550-36-7NA 212NA 211HerbicideSulfonylurea
salt
Mesosulfuron-methyl208465-21-8#####NA 993HerbicideSulfonylurea
Metsulfuron5585-64-8NA 183NA 182HerbicideSulfonylurea
Metsulfuron-methyl74223-64-6#####2222HerbicideSulfonylurea
Nicosulfuron111991-09-4#####3829HerbicideSulfonylurea
Oxasulfuron144651-06-9#####NA 991HerbicideSulfonylurea
Primisulfuron-methyl86209-51-0#####5103HerbicideSulfonylurea
Prosulfuron94125-34-5#####5115HerbicideSulfonylurea
Pyrazosulfuron98389-04-9NA 205NA 205HerbicideSulfonylurea
Pyrazosulfuron-ethyl93697-74-6NA 218NA 217HerbicideSulfonylurea
Rimsulfuron122931-48-0#####3835HerbicideSulfonylurea
Sulfometuron74223-56-6NA 206NA 205HerbicideSulfonylurea
Sulfometuron methyl74222-97-2#####2149HerbicideSulfonylurea
Sulfosulfuron141776-32-1856015136HerbicideSulfonylurea
Thifensulfuron79277-67-1NA 183NA 182HerbicideSulfonylurea
Thifensulfuron-methyl79277-27-3#####2237HerbicideSulfonylurea
Triasulfuron82097-50-5#####5100HerbicideSulfonylurea
Tribenuron106040-48-6NA 206NA 205HerbicideSulfonylurea
Tribenuron methyl101200-48-0#####2338HerbicideSulfonylurea
Triflusulfuron-methyl126535-15-7#####3875HerbicideSulfonylurea
Tritosulfuron142469-14-5NA 234NA 234HerbicideSulfonylurea
Butylate2008-41-541405565HerbicideThiocarbamate
Calcium thylenebis5895-18-114501NA 139MicrobiocideDithiocarbamate
(dithiocarbamate)
Cufraneb11096-18-7NA 181NA 180FungicideDithiocarbamate
Cycloate1134-23-241301516HerbicideThiocarbamate
Diammonium60731314502NA 140MicrobiocideDithiocarbamate
ethylenebis(dithiocarbamate)
Dimepiperate61432-55-1NA 186NA 185HerbicideThiocarbamate
EPTC759-94-441401264HerbicideThiocarbamate
Esprocarb85785-20-2NA 203NA 202HerbicideThiocarbamate
Ethiolate2941-55-1#####1793HerbicideThiocarbamate
Fenothiocarb62850-32-2NA 188NA 187InsecticideThiocarbamate
Ferbam14484-64-134801288FungicideDithiocarbamate
Ferric nitroso dimethyl83542-83-0#####NA 149MicrobiocideDithiocarbamate
dithiocarbamate
Furathiocarb65907-30-4NA 176NA 52InsecticideThiocarbamate
Isopolinate3134-70-1NA 232NA 232HerbicideThiocarbamate
Mancopper53988-93-5NA 181NA 180FungicideDithiocarbamate
Mancozeb223310014504211FungicideDithiocarbamate,
Inorganic-Zinc
Maneb12427-38-214505369FungicideDithiocarbamate
Maneb and nickel sulfate8005-46-7#####NA 158FungicideDithiocarbamate,
hexahydrate (014505 + 050505)Inorganic-Nickel
Manganous15339-36-334802NA 304FungicideDithiocarbamate
dimethyldithiocarbamate
Mercuric dimethyl15415-64-234808709MicrobiocideInorganic-Mercury,
dithiocarbamateHeavy metal,
Dithiocarbamate
Metam sodium, dihydrate137-42-839003NA 163Fumigant,Dithiocarbamate
Fungicide,
Microbiocide,
Algaecide,
Nematicide
Metam-sodium6734-80-139003616Fumigant,Dithiocarbamate
Herbicide,
Fungicide,
Microbiocide,
Algaecide,
Nematicide
Methasulfocarb66952-49-6NA 202NA 201Fungicide,Thiocarbamate
Plant Growth
Regulator
Methiobencarb18357-78-3NA 232NA 232HerbicideThiocarbamate
Metiram9006-42-214601493FungicideDithiocarbamate,
Inorganic-Zinc
Molinate2212-67-141402449HerbicideThiocarbamate
Molinate sulfoxideNA 1052NA 1564080BreakdownThiocarbamate
product
Morpholinomethyl31848-11-0#####NA 158MicrobiocideDithiocarbamate
dimethyldithiocarbamate
Nabam142-59-614503417Fungicide,Dithiocarbamate
Herbicide
Orbencarb34622-58-7NA 189NA 188HerbicideThiocarbamate
Pebulate1114-71-241403590HerbicideThiocarbamate
Phenylmercuric32407-99-166008NA 555Microbiocide,Organomercury,
dimethyldithiocarbamateFungicideDithiocarbamate,
Heavy metal
Potassium ammonium22221-14-314507NA 141MicrobiocideDithiocarbanaate
ethylenebis(dithiocarbamate)
Potassium dimethyl dithiocarbamate128-03-0348031934MicrobiocideDithiocarbamate
Potassium N-hydroxymethyl-51026-28-9#####1824N/ADithiocarbamate
N-methyldithio carbamate
Potassium N-methyldithiocarbamate137-41-739002970Fumigant,Dithiocarbamate
Fungicide,
Microbiocide,
Algaecide,
Nematicide
Propineb12071-83-9#####NA 155Fungicide,Dithiocarbamate,
MicrobiocideInorganic-Zinc
Prosulfocarb52888-80-9NA 185NA 184HerbicideThiocarbamate
Prothiocarb19622-08-3NA 183NA 182FungicideThiocarbamate
Prothiocarb hydrochloride19622-19-6NA 200NA 199FungicideThiocarbamate
Pyributicarb88678-67-5NA 229NA 229HerbicideThiocarbamate
S-tert-Butyl2212-63-7#####NA 128HerbicideThiocarbamate
dipropylthiocarbamate
Sodium dimethyl dithiocarbamate128-04-134804548FungicideDithiocarbamate
Sulfallate95-06-739001115HerbicideDithiocarbamate
Tert-butyl dimethyl trithioperoxycarbamate3304-97-0348071383RodentDithiocarbamate
Repellent
Tert-NA 1130NA 16691383N/ADithiocarbamate
butyldimethyltrithioperoxycarbamate,
other related
Thiobencarb28249-77-6#####1933HerbicideThiocarbamate
Thiobencarb sulfoxideNA 1042NA 1392937BreakdownThiocarbamate
product
Thiodicarb59669-26-0#####2202Molluscicide,Thiocarbamate
Insecticide
Thiram137-26-879801589FungicideDithiocarbamate
Thiram and NAD and IBA and75497-92-656011NA 463Fungicide,Dithiocarbamate
2-methyl-1-Plant Growth
naphthaleneacetamide and 2-Regulator
methyl-1-naphthaleneacetic
acid
Tiocarbazil36756-79-3#####NA 911HerbicideThiocarbamate
Triallate2303-17-57880249HerbicideThiocarbamate
Tricopper dichloride7076-63-3#####NA 152MicrobiocideDithiocarbamate,
dimethyldithiocarbamateInorganic-Copper
Vernolate1929-77-7414041987HerbicideThiocarbamate
Zineb12122-67-714506627FungicideDithiocarbamate,
Inorganic-Zinc
Zineb-ethylene thiuramNA 1465NA 217NA 216FungicideDithiocarbamate,
disulfide adductInorganic-Zinc
Ziram137-30-434805629Fungicide,Dithiocarbamate,
Microbiocide,Inorganic-Zinc
Dog and Cat
Repellent
Ziram, cyclohexylamine16509-79-8348061328Dog and CatDithiocarbamate,
complexRepellent,Inorganic-Zinc
Fungicide
1,3,5-Triethylhexahydro-s-7779-27-382901NA 823FungicideTriazine
triazine
2-(Diethylamino)-4-3004-70-480812NA 780N/ATriazine
(isopropylamino)-6-methoxy-s-
triazine
2-chloro-4-29450-57-5#####NA 135N/ATriazine
((hydroxymethyl)amino)-6-
(isopropylamino)-s-triazine
3-(chloromethyl)-4-ketobenz-24310-41-6#####NA 162ImpurityTriazine
1,2,3-triazine (as impurity)
3-(Hydroxymethyl)-4-24310-40-5#####NA 162ImpurityTriazine
ketobenz-1,2,3-triazine (as
impurity)
Aatram (propachlor with8070-76-680816NA 781HerbicideTriazine,
atrazine) (019101 + 080803)Chloroacetanilide
Ametryne834-12-88080118HerbicideTriazine
Ametryne, other relatedNA 1071NA 16090018HerbicideTriazine
Anilazine101-05-380811256FungicideTriazine
Atraton1610-17-9808024050HerbicideTriazine
Atrazine1912-24-98080345HerbicideTriazine
Atrazine dealkylatedNA 1059NA 1574052BreakdownTriazine
product
Atrazine, other relatedNA 1072NA 16090045HerbicideTriazine
Aziprotryne4658-28-0#####NA 130HerbicideTriazine
Chlorazine580-48-380806NA 777N/ATriazine
Cyanatryn21689-84-9NA 230NA 229HerbicideTriazine
Cyanazine21725-46-2#####1640HerbicideTriazine
Cyanazine acidNA 1328NA 178NA 178BreakdownTriazine
product
Cyanazine amideNA 1170NA 176NA 164BreakdownTriazine
product
Cyanazine, other relatedNA 1133NA 16691640HerbicideTriazine
Cyanuric acid108-80-5814022138Microbiocide,Triazine
Water
Treatment
Cyanuric acid, monosodium2624-17-1NA 1221031Microbiocide,Triazine
saltWater
Treatment
Cybutryne28159-98-0#####4033MicrobiocideTriazine
Cyprazine22936-86-3#####1701HerbicideTriazine
Cyromazine66215-27-8#####2286InsecticideTriazine
Deethyl ametryneNA 1168NA 176NA 164BreakdownTriazine
product
Deethyl hydroxyatrazineNA 1330NA 179NA 178BreakdownTriazine
product
Deethyl-atrazineNA 1058NA 1574051BreakdownTriazine
product
Deethyl-simazineNA 1047NA 1544096BreakdownTriazine
product
DeethylhydroxysimazineNA 1064NA 1595031BreakdownTriazine
product
Deisopropyl atrazineNA 1169NA 176NA 164BreakdownTriazine
product
Deisopropyl hydroxyatrazineNA 1331NA 179NA 178BreakdownTriazine
product
Deisopropyl prometrynNA 1334NA 179NA 179BreakdownTriazine
product
Desamino-metribuzinNA 1473NA 219NA 219BreakdownTriazine
product
Desmetryne1014-69-380810NA 779HerbicideTriazine
DiaminochlorotriazineNA 856NA 1595028BreakdownTriazine
product
DiaminohydroxytriazineNA 857NA 1595032BreakdownTriazine
product
Dichloro-s-triazinetrione2782-57-281401204Microbiocide,Triazine
Water
Treatment
Dichloroisocyanuric acid,2244-21-5814032Microbiocide,Triazine
potassium saltWater
Treatment
Didealkyl atrazineNA 1329NA 178NA 178BreakdownTriazine
product
Didealkyl hydroxyatrazineNA 1332NA 179NA 178BreakdownTriazine
product
Diketo-desamino-metribuzinNA 1475NA 219NA 219BreakdownTriazine
product
Diketo-metribuzinNA 1474NA 219NA 219BreakdownTriazine
product
Dimethametryn22936-75-0808152287HerbicideTriazine
Dipropetryn4147-51-7#####2532HerbicideTriazine
Eglinazine6616-80-4NA 207NA 207HerbicideTriazine
Eglinazine-ethyl6616-80-4NA 218NA 217HerbicideTriazine
Ethiozin (ebuzin/tycor)64529-56-2#####NA 15N/ATriazine
Hexahydro-1,3,5-triethyl-S-108-74-7NA 1251670HerbicideTriazine
triazine
Hexahydro-1,3,5-tris (2-1028251833011171MicrobiocideTriazine
hydroxyethyl)-s-triazine
Hexahydro-1,3,5-tris(2-25254-50-6#####1915N/ATriazine
hydroxypropyl)-s-triazine
Hexahydro-1,3,5-tris(3-751061#####NA 127N/ATriazine
methoxypropyl)-1,3,5-triazine
Hexazinone51235-04-2#####1871HerbicideTriazine
Hydroxyatrazine2163-68-0NA 178NA 178BreakdownTriazine
product
Ipazin1912-25-0#####NA 130N/ATriazine
Isomethiozin57052-04-7#####NA 875N/ATriazine
Metamitron41394-05-2NA 1352672HerbicideTriazine
Methometon1771-07-9#####NA 156N/ATriazine
Methoprotryne841-06-5#####NA 154HerbicideTriazine
Metribuzin21087-64-9#####1692HerbicideTriazine
Metribuzin-DANA 1053NA 1564079BreakdownTriazine
product
Mono (trichloro) tetra30622-37-881406856Microbiocide,Triazine
(monopotassium dichloro)Water
penta-s-triazineTreatment
MPMT845-52-3827012695N/ATriazine
Potassium 1,3-dichloro-2,4,6-NA 173NA 3461650N/ATriazine
trioxo hexahydro-s-triazine
Prefox (cyprazine with8071-40-7#####NA 886HerbicideTriazine
ethiolate)
Procyanazine32889-48-8#####NA 908HerbicideTriazine
Proglinazine68228-20-6NA 209NA 209HerbicideTriazine
Proglinazine-ethyl68228-18-2NA 218NA 218HerbicideTriazine
Prometon1610-18-080804499HerbicideTriazine
Prometryn7287-19-680805502HerbicideTriazine
Propazine139-40-280808504HerbicideTriazine
Pymetrozine123312-89-0#####5232InsecticideTriazine
Sebuthylazine7286-69-3#####NA 127N/ATriazine
Secbumeton26259-45-0#####2849HerbicideTriazine
Simazine122-34-980807531HerbicideTriazine
Simetone673-04-1#####3532HerbicideTriazine
Simetryn1014-70-6#####4097N/ATriazine
Sodium dichloro-s-2893-78-981404205Microbiocide,Triazine
triazinetrioneWater
Treatment
Sodium dichloro-s-51580-86-0814071818Microbiocide,Triazine
triazinetrione dihydrateWater
Treatment
Sym-triazine108-80-581402893Microbiocide,Triazine
Water
Treatment
Terbumeton33693-04-8NA 190NA 189HerbicideTriazine
Terbuthylazine5915-41-3808143004Algaecide,Triazine
Herbicide,
Microbiocide
Terbutryn886-50-0808131691HerbicideTriazine
Terbutryn, other relatedNA 1136NA 16791691HerbicideTriazine
Triaziflam131475-57-5NA 234NA 233HerbicideTriazine
Trichloro melamine2107336771011023MicrobiocideTriazine
Trichloro-s-triazinetrione87-90-181405407Microbiocide,Triazine
Water
Treatment
Trietazine1912-26-180809NA 778HerbicideTriazine
1,3-Diphenyl urea102-07-8NA 186NA 185Plant GrowthUrea
Regulator
3,4-Dichloromethylphenyl ureaNA 1335NA 179NA 179BreakdownUrea
product
3,4-Dichlorophenyl urea154536NA 179NA 179BreakdownUrea
product
3-(Trifluoromethyl)phenyl urea13114-87-9NA 179NA 178BreakdownUrea
product
Amidosulfuron120923-37-7NA 183NA 183HerbicideSulfonylurea
Anisuron2689-43-2#####NA 138HerbicideBenzoylurea
Azimsulfuron120162-55-2#####NA 112HerbicideSulfonylurea
Bensulfuron99283-01-9NA 181NA 180HerbicideSulfonylurea
Bensulfuron methyl83055-99-6#####2263HerbicideSulfonylurea
BentaluronNA 1405NA 197NA 197FungicideUrea
Benzthiazuron1929-88-0#####NA 133HerbicideUrea
Buthiuron30043-55-1NA 230NA 230HerbicideUrea
Buturon3766-60-7#####NA 119HerbicideUrea
Chlorbromuron13360-45-7907011733HerbicideUrea
Chloreturon20782-58-5NA 231NA 230HerbicidePhenylurea
Chlorimuron99283-00-8NA 204NA 203HerbicideSulfonylurea
Chlorimuron ethyl90982-32-4#####2458HerbicideSulfonylurea
Chlorotoluron15545-48-9#####NA 122HerbicideUrea
Chloroxuron1982-47-425501576HerbicideUrea
Chlorsulfuron64902-72-3#####2143HerbicideSulfonylurea
Cinosulfuron94593-91-6NA 183NA 183HerbicideSulfonylurea
Cumyluron99485-76-4NA 228NA 228HerbicideUrea
Cyclosulfamuron136849-15-5NA 204NA 203HerbicideSulfonylurea
Cycluron2163-69-135504NA 306HerbicideUrea
Daimuron42609-52-9NA 204NA 204HerbicidePhenylurea
DemethylfluometuronNA 1333NA 179NA 178BreakdownUrea
product
Dichloral urea116-52-9#####NA 115HerbicideUrea
Difenoxuron14214-32-5#####NA 156HerbicideUrea
Diflubenzuron35367-38-5#####1992InsecticideBenzoylurea
Dimefuron34205-21-5NA 186NA 185HerbicideUrea
Diuron330-54-135505231HerbicideUrea
Ethametsulfuron111353-84-5NA 212NA 212HerbicideSulfonylurea
Ethametsulfuron-methyl97780-06-8#####NA 43HerbicideSulfonylurea
Ethidimuron30043-49-3#####NA 994HerbicideUrea
Ethoxysulfuron126801-58-9NA 226NA 225HerbicideSulfonylurea
Fenuron101-42-8355074072HerbicideUrea
Fenuron trichloroacetate4482-55-7355085035HerbicideUrea
Flazasulfuron104040-78-0NA 229NA 228HerbicideSulfonylurea
Flucycloxuron113036-88-7#####NA 109HerbicideBenzoylurea
Flucycloxuron, (E)94050-52-9NA 201NA 200HerbicideBenzoylurea
Flufenoxuron101463-69-8#####NA 901InsecticideBenzoylurea
Fluometuron2164-17-235503166HerbicideUrea
Fluothiuron33439-45-1NA 232NA 232HerbicidePhenylurea
Flupyrsulfuron150315-10-9NA 205NA 204HerbicideSulfonylurea
Flupyrsulfuron-methylNA 1460NA 216NA 216HerbicideSulfonylurea
Flupyrsulfuron-methyl, sodium144740-54-5NA 218NA 217HerbicideSulfonylurea
salt
Forchlorfenuron68157-60-8#####5557Plant GrowthUrea
Regulator
Halosulfuron100784-20-1#####3919HerbicideSulfonylurea
Hexaflumuron86479-06-3#####3899InsecticideBenzoylurea
Imazosulfuron122548-33-8NA 229NA 229HerbicideSulfonylurea
Iodosulfuron methyl185119-76-0NA 212NA 211HerbicideSulfonylurea
Iodosulfuron methyl, sodium144550-36-7NA 212NA 211HerbicideSulfonylurea
salt
Isononuron28805-78-9#####NA 151HerbicideUrea
Isoproturon34123-59-6#####NA 155HerbicideUrea
Isouron55861-78-4#####NA 101HerbicideUrea
Linuron330-55-235506361HerbicideUrea
Lufenuron103055-07-8NA 184NA 183InsecticideBenzoylurea
Mesosulfuron-methyl208465-21-8#####NA 993HerbicideSulfonylurea
Methabenzthiazuron18691-97-9#####NA 133HerbicideUrea
Methiuron21540-35-2#####NA 145HerbicideUrea
Methyldymron42609-73-4NA 205NA 204HerbicidePhenylurea
Metobenzuron111578-32-6#####NA 37HerbicideUrea
Metobromuron3060-89-735901NA 313HerbicideUrea
Metoxuron19937-59-8#####NA 135HerbicideUrea
Metsulfuron5585-64-8NA 183NA 182HerbicideSulfonylurea
Metsulfuron-methyl74223-64-6#####2222HerbicideSulfonylurea
Monisouron55807-46-0NA 233NA 232HerbicideUrea
Monolinuron1746-81-2#####NA 119HerbicideUrea
Monolinuron with paraquat69312-67-0#####NA 119HerbicideUrea, Bipyridylium
dichloride
Monuron150-68-535501408HerbicideUrea
Monuron-TCA140-41-035502409HerbicideUrea
Neburon555-37-312001424HerbicideUrea
Nicosulfuron111991-09-4#####3829HerbicideSulfonylurea
Norea18530-56-835801435HerbicideUrea
Norea (stereochemistry2163-79-3NA 201NA 200HerbicideUrea
unspecified)
Norea, other relatedNA 1096NA 16390435HerbicideUrea
Novaluron116714-46-6NA 226NA 226HerbicideBenzoylurea
Oxasulfuron144651-06-9#####NA 991HerbicideSulfonylurea
Parafluron7159-99-135510NA 307HerbicideUrea
Pencycuron66063-05-6#####NA 103FungicideUrea
Penfluron35367-31-8#####NA 100HerbicideUrea
Phenobenzuron449583#####NA 133HerbicideBenzoylurea
Primisulfuron-methyl86209-51-0#####5103HerbicideSulfonylurea
Prosulfuron94125-34-5#####5115HerbicideSulfonylurea
Pyrazosulfuron98389-04-9NA 205NA 205HerbicideSulfonylurea
Pyrazosulfuron-ethyl93697-74-6NA 218NA 217HerbicideSulfonylurea
Rimsulfuron122931-48-0#####3835HerbicideSulfonylurea
Siduron1982-49-635509603HerbicideUrea
Sulfometuron74223-56-6NA 206NA 205HerbicideSulfonylurea
Sulfometuron methyl74222-97-2#####2149HerbicideSulfonylurea
Sulfosulfuron141776-32-1856015136HerbicideSulfonylurea
Tebuthiuron34014-18-1#####1810HerbicideUrea
Teflubenzuron83121-18-0#####NA 33InsecticideBenzoylurea
Tetrafluoron27954-37-6#####NA 145HerbicidePhenylurea
Thiazafluron25366-23-8NA 190NA 189HerbicideUrea
Thidiazuron51707-55-2#####2162Defoliant, PlantUrea
Growth
Regulator
Thifensulfuron79277-67-1NA 183NA 182HerbicideSulfonylurea
Thifensulfuron-methyl79277-27-3#####2237HerbicideSulfonylurea
Triasulfuron82097-50-5#####5100HerbicideSulfonylurea
Tribenuron106040-48-6NA 206NA 205HerbicideSulfonylurea
Tribenuron methyl101200-48-0#####2338HerbicideSulfonylurea
Triflumuron64628-44-0#####2961InsecticideBenzoylurea
Triflusulfuron-methyl126535-15-7#####3875HerbicideSulfonylurea
Trimeturon3050-27-9#####NA 121HerbicideUrea
Tritosulfuron142469-14-5NA 234NA 234HerbicideSulfonylurea
Bromacil314-40-91230183HerbicideUracil
Bromacil, dimethylamine salt69484-13-512304840HerbicideUracil
Bromacil, lithium salt53404-19-6123021573HerbicideUracil
Bromacil, sodium salt69484-12-412303842HerbicideUracil
Butafenacil134605-64-4#####NA 992HerbicideUracil
Flupropacil120890-70-2NA 229NA 229HerbicideUracil
Isocil314-42-111801NA 119HerbicideUracil
Lenacil95177#####NA 155HerbicideUracil
Terbacil5902-51-212701532HerbicideUracil
2-Hydroxy alachlorNA 943NA 1832602BreakdownChloroacetanilide
product
3,4,5-tribromo salicylanilide,NA 1122NA 16590833MicrobiocideAnilide
other related
3,5-dibromosalicylanilide2577-72-2774051256MicrobiocideAnilide
5,4-dibromosalicylanilideNA 1024NA 1221071MicrobiocideAnilide
Aatram (propachlor with8070-76-680816NA 781HerbicideTriazine,
atrazine) (019101 + 080803)Chloroacetanilide
Acetochlor34256-82-1#####2349HerbicideChloroacetanilide
Alachlor15972-60-890501678HerbicideChloroacetanilide
Benodanil15310-01-7#####NA 154FungicideAnilide
Butachlor23184-66-9#####4056HerbicideChloroacetanilide
Butenachlor87310-56-3NA 206NA 206HerbicideChloroacetanilide
Clomeprop84496-56-0NA 204NA 203HerbicideAnilide
Cyprofuram69581-33-5NA 186NA 185FungicideAnilide
Cypromid2759-71-926101178HerbicideAnilide
Delachlor24353-58-0#####NA 132HerbicideChloroacetanilide
Diethatyl-ethyl38727-55-8#####1995HerbicideChloroacetanilide
Diflufenican83164-33-4NA 184NA 183HerbicideAnilide
Dimethachlor50563-36-5NA 184NA 183HerbicideChloroacetanilide
Etobenzanid79540-50-4NA 229NA 228HerbicideAnilide
Fenasulam78357-48-9NA 231NA 231HerbicideAnilide
Flufenacet142459-58-3#####5293HerbicideAnilide
FlufenicanNA 1568NA 234NA 234HerbicideAnilide
Flutolanil66332-96-5#####2305FungicideAnilide
Mefenacet73250-68-7NA 189NA 188HerbicideAnilide
Mefluidide53780-34-0#####5082Herbicide,Anilide
Plant Growth
Regulator
Mefluidide, diethanolamine salt53780-36-2#####1955HerbicideAnilide
Mefluidide, potassium salt83601-83-6#####5083HerbicideAnilide
Mepronil55814-41-0NA 189NA 188FungicideAnilide
Metazachlor67129-08-2NA 184NA 183HerbicideChloroacetanilide
Metolachlor51218-45-2#####1996HerbicideChloroacetanilide
Metolachlor, (S)87392-12-9#####5133HerbicideChloroacetanilide
Monalide7287-36-7#####NA 134HerbicideAnilide
Naproanilide52570-16-8NA 233NA 232HerbicideAnilide
Ofurace58810-48-3NA 189NA 188FungicideAnilide
Oxadixyl77732-09-3#####3539FungicideAnilide
Perfluidone37924-13-3#####1895HerbicideAnilide
Perfluidone, diethanolamineNA 991NA 6711896HerbicideAnilide
salt
Pretilachlor51218-49-6NA 184NA 184HerbicideChloroacetanilide
Propachlor1918-16-719101511HerbicideChloroacetanilide
Propanil709-98-828201503HerbicideAnilide
Propisochlor86763-47-5NA 233NA 233HerbicideChloroacetanilide
Prynachlor21267-72-1#####NA 138Herbicide,Chloroacetanilide
Plant Growth
Regulator
Pyracarbolid24691-76-7NA 210NA 209FungicideAnilide
Salicylanilide87-17-277407450Fungicide,Anilide
Microbiocide
Sodium salicylanilide251930#####NA 145FungicideAnilide
Thenylchlor96491-05-3NA 229NA 229HerbicideChloroacetanilide
Triclocarban101-20-227901844N/AAnilide
1,2,4-triazole288-88-0NA 9683560N/AAzole
1H-benzo triazole95-14-7NA 4932418N/AAzole
2,2′-Dithiobisbenzothiazole120-78-59202NA 109Fungicide,Mercaptobenzothiazole
Microbiocide,
Insecticide
2-(2′-hydroxy-5-methyl2440-22-4NA 1032607FungicideAzole
phenyl)-benzotriazole
2-(dithiocyanomethylthio)-NA 1346NA 192NA 191FungicideMercaptobenzothiazole
benzothiazole
2-79910-32-0#####NA 925MicrobiocideMercaptobenzothiazole
(thiocyanomethylthio)benzothiazole
with 2′-hydroxyethyl-2,3-
dibromopropionate
2-EEEBC62732-91-6#####1983FungicideBenzimidazole
2-Mercaptobenzothiazole149-30-451701556Fungicide,Mercaptobenzothiazole
Microbiocide
2-Mercaptobenzothiazole, 1-5468-43-951702NA 423Fungicide,Mercaptobenzothiazole
(hydroxyethyl)pyridinium saltMicrobiocide
2-Mercaptobenzothiazole,53404-53-851708NA 426Fungicide,Mercaptobenzothiazole
ferric saltMicrobiocide
2-Mercaptobenzothiazole,53404-58-39201NA 108Fungicide,Mercaptobenzothiazole
manganese saltMicrobiocide,
Insecticide
2-Mercaptobenzothiazole,5902-85-251706NA 424Fungicide,Mercaptobenzothiazole
monoethanolammonium saltMicrobiocide
2-Mercaptobenzothiazole,7778-70-351707NA 425Fungicide,Mercaptobenzothiazole
potassium saltMicrobiocide
2-Mercaptobenzothiazole,2492-26-4517043064Microbiocide,Mercaptobenzothiazole
sodium saltFungicide
2-Mercaptobenzothiazole,2492-26-451704613Fungicide,Mercaptobenzothiazole
sodium saltMicrobiocide
2-Mercaptobenzothiazole, zinc155-04-4517051449Fungicide,Mercaptobenzothiazole,
saltMicrobiocideInorganic-Zinc
5-Chloro-2-5331-91-9NA 200NA 199N/AMercaptobenzothiazole
mercaptobenzothiazole
5-Chloro-2-5406-97-3517031238MicrobiocideMercaptobenzothiazole
mercaptobenzothiazole, lauryl
pyridinium salt
5-Chloro-2-5406-97-3NA 4211597Microbiocide,Mercaptobenzothiazole
mercaptobenzothiazole, laurylFungicide
pyridinium salt
5-Chloro-2-53404-93-651709NA 427Microbiocide,Mercaptobenzothiazole,
mercaptobenzothiazole, zincFungicideInorganic-Zinc
salt
Azaconazole60207-31-0#####NA 105Insecticide,Azole
Fungicide
Benomyl17804-35-2991011552FungicideBenzimidazole
Bitertanol55179-31-2#####NA 959FungicideAzole
Bromuconazole116255-48-2#####NA 8FungicideAzole
Carbendazim10605-21-7#####2176FungicideBenzimidazole
Carbendazim hydrochloride37574-18-8#####NA 121FungicideBenzimidazole
Carbendazim phosphate52316-55-9991021974FungicideBenzimidazole
CGA-6425160207-93-4#####2452FungicideAzole
Chlorfenapyr122453-73-0#####3938InsecticidePyrazole
Chlorflurazole3615-21-2#####NA 139N/ABenzimidazole
Cyazofamid120116-88-3NA 216NA 215FungicideAzole
Cypendazole28559-00-4#####NA 156N/ABenzimidazole
Cyproconazole94361-06-5#####5105FungicideAzole
Difenoconazole119446-68-3#####5024FungicideAzole
Diniconazole83657-18-5#####2500FungicideAzole
Diniconazole (stereochemistry83657-24-3NA 200NA 200FungicideAzole
unspecified)
Fenapanil61019-78-1#####2083FungicideAzole
Fenbuconazole114369-43-6#####3905FungicideAzole
Fluotrimazole31251-03-3NA 207NA 207FungicideAzole
Fluquinconazole136426-54-5NA 184NA 183FungicideAzole
Flusilazole85509-19-9#####2278FungicideAzole
Flutriafol76674-21-0#####NA 107FungicideAzole
Fuberidazole3878-19-1#####NA 150FungicideBenzimidazole
Furconazole112839-33-5NA 196NA 196FungicideAzole
Furconazole-cis112839-32-4NA 208NA 207FungicideAzole
Hexaconazole79983-71-4#####NA 23FungicideAzole
Imazalil35554-44-0#####2084FungicideAzole
Imazalil sulfate58594-72-2#####NA 921FungicideAzole
Imibenconazole86598-92-7NA 205NA 204FungicideAzole
Isoxachlortole141112-06-3NA 232NA 232HerbicideCyclopropylisoxazole
Metconazole125116-23-6#####NA 101FungicideAzole
Metronidazole443-48-1#####2208MicrobiocideAzole
Myclobutanil88671-89-0#####2245FungicideAzole
Naphthyl triazole stilbeneNA 742NA 1352698N/AAzole
monosulfonate
Paclobutrazol76738-62-0#####2259Plant GrowthAzole
Regulator
Penconazole66246-88-6#####NA 109FungicideAzole
Prochloraz67747-09-5#####NA 29FungicideAzole
Prochloraz - manganese75747-77-2#####NA 104FungicideAzole
complex (4:1)
Prochloraz zinc complexNA 1555NA 226NA 226FungicideAzole
Propiconazole60207-90-1#####2276FungicideAzole
Pyrazoxyfen71561-11-0NA 189NA 189HerbicidePyrazole
R 23 979 imazalil baseNA 451NA 8092844FungicideAzole
TCMTB21564-17-035603971Microbiocide,Mercaptobenzothiazole
Fungicide
Tebuconazole107534-96-3#####3850FungicideAzole
Tebufenpyrad119168-77-390102NA 845InsecticidePyrazole
Terrazole2593-15-984701580FungicideAzole
Tetraconazole112281-77-3#####NA 979FungicideAzole
Thiabendazole148-79-860101587FungicideBenzimidazole
Thiabendazole, hypophosphite28558-32-9601021952FungicideBenzimidazole
salt
Thiophanate23564-06-9#####1684FungicideBenzimidazole
Thiophanate-methyl23564-05-8#####1696FungicideBenzimidazole
precursor
Tolyl triazole29395-43-1NA 9622950N/AAzole
Triadimefon43121-43-3#####2133FungicideAzole
Triadimenol55219-65-3#####2307Fungicide,Azole
Breakdown
product
Triazbutil16227-10-4#####NA 931FungicideAzole
Tricyclazole41814-78-2#####5002FungicideAzole
Triflumizole68694-11-1#####2260FungicideAzole
Triflumizole99387-89-0NA 201NA 201FungicideAzole
Triticonazole131983-72-7#####NA 101FungicideAzole
Uniconazole83657-22-1#####NA 38Plant GrowthAzole
Regulator
2-EEEBC62732-91-6#####1983FungicideBenzimidazole
Benomyl17804-35-2991011552FungicideBenzimidazole
Carbendazim10605-21-7#####2176FungicideBenzimidazole
Carbendazim hydrochloride37574-18-8#####NA 121FungicideBenzimidazole
Carbendazim phosphate52316-55-9991021974FungicideBenzimidazole
Chlorflurazole3615-21-2#####NA 139N/ABenzimidazole
Cypendazole28559-00-4#####NA 156N/ABenzimidazole
Fuberidazole3878-19-1#####NA 150FungicideBenzimidazole
Thiabendazole148-79-860101587FungicideBenzimidazole
Thiabendazole, hypophosphite28558-32-9601021952FungicideBenzimidazole
salt
Thiophanate23564-06-9#####1684FungicideBenzimidazole
Thiophanate-methyl23564-05-8#####1696FungicideBenzimidazole
precursor
1-(3-51971-67-6#####NA 110N/ACarboxamide
chlorophthalimido)cyclohexane
carboxamide
Carboxin5234-68-4902011755FungicideCarboxamide
Cisanilide34484-77-0#####NA 144HerbicideCarboxamide
Cyclafuramide34849-42-8#####NA 132FungicideCarboxamide
Fenfuram24691-80-3NA 188NA 187FungicideCarboxamide
Furmecyclox (Xyligen B)60568-05-0#####NA 18FungicideCarboxamide
Methfuroxam28730-17-8#####NA 949FungicideCarboxamide
Metsulfovax21452-18-6NA 189NA 188FungicideCarboxamide
Nitrofurazone (not subject to59-87-0#####NA 128N/ACarboxamide
FIFRA: 8709-e pm 24)
Oxycarboxin5259-88-1902021434FungicideCarboxamide
p-Benzoquinone61566-21-0#####NA 133N/ACarboxamide
semicarbazone
Chlozolinate72391-46-9NA 183NA 182FungicideDicarboximide
Iprodione36734-19-7#####2081FungicideDicarboximide
Myclozolin54864-61-8NA 209NA 208FungicideDicarboximide
N-(2-Ethylhexyl)-1-isopropyl-13358-11-7#####NA 121SynergistDicarboximide
4-methyl-4-cyclohexene-1,2-
dicarboximide
N-octyl bicycloheptene113-48-457001396SynergistDicarboximide
dicarboximide
Vinclozolin50471-44-8#####2129FungicideDicarboximide
Calcium5895-18-114501NA 139MicrobiocideDithiocarbamate
ethylenebis(dithiocarbamate)
Cufraneb11096-18-7NA 181NA 180FungicideDithiocarbamate
Diammonium60731314502NA 140MicrobiocideDithiocarbamate
ethylenebis(dithiocarbamate)
Ferbam14484-64-134801288FungicideDithiocarbamate
Ferric nitroso dimethyl83542-83-0#####NA 149MicrobiocideDithiocarbamate
dithiocarbamate
Mancopper53988-93-5NA 181NA 180FungicideDithiocarbamate
Mancozeb223310014504211FungicideDithiocarbamate,
Inorganic-Zinc
Maneb12427-38-214505369FungicideDithiocarbamate
Maneb and nickel sulfate8005-46-7#####NA 158FungicideDithiocarbamate,
hexahydrate (014505 + 050505)Inorganic-Nickel
Manganous15339-36-334802NA 304FungicideDithiocarbamate
dimethyldithiocarbamate
Mercuric dimethyl15415-64-234808709MicrobiocideInorganic-Mercury,
dithiocarbamateHeavy metal,
Dithiocarbamate
Metam sodium, dihydrate137-42-839003NA 163Fumigant,Dithiocarbamate
Fungicide,
Microbiocide,
Algaecide,
Nematicide
Metam-sodium6734-80-139003616Fumigant,Dithiocarbamate
Herbicide,
Fungicide,
Microbiocide,
Algaecide,
Nematicide
Metiram9006-42-214601493FungicideDithiocarbamate,
Inorganic-Zinc
Morpholinomethyl31848-11-0#####NA 158MicrobiocideDithiocarbamate
dimethyldithiocarbamate
Nabam142-59-614503417Fungicide,Dithiocarbamate
Herbicide
Phenylmercuric32407-99-166008NA 555Microbiocide,Organomercury,
dimethyldithiocarbamateFungicideDithiocarbamate,
Heavy metal
Potassium ammonium22221-14-314507NA 141MicrobiocideDithiocarbamate
ethylenebis(dithiocarbamate)
Potassium dimethyl dithiocarbamate128-03-0348031934MicrobiocideDithiocarbamate
Potassium N-hydroxymethyl-51026-28-9#####1824N/ADithiocarbamate
N-methyldithio carbamate
Potassium N-methyldithio137-41-739002970Fumigant,Dithiocarbamate
carbamateFungicide,
Microbiocide,
Algaecide,
Nematicide
Propineb12071-83-9#####NA 155Fungicide,Dithiocarbamate,
MicrobiocideInorganic-Zinc
Sodium dimethyl dithio128-04-134804548FungicideDithiocarbamate
carbamate
Sulfallate95-06-739001115HerbicideDithiocarbamate
Tert-butyl dimethyl trithio3304-97-0348071383RodentDithiocarbamate
peroxycarbamateRepellent
Tert-NA 1130NA 16691383N/ADithiocarbamate
butyldimethyltrithioperoxycarbamate,
other related
Thiram137-26-879801589FungicideDithiocarbamate
Thiram and NAD and IBA and75497-92-656011NA 463Fungicide,Dithiocarbamate
2-methyl-1-Plant Growth
naphthaleneacetamide and 2-Regulator
methyl-1-naphthaleneacetic
acid
Tricopper dichloride7076-63-3#####NA 152MicrobiocideDithiocarbamate,
dimethyldithiocarbamateInorganic-Copper
Zineb12122-67-714506627FungicideDithiocarbamate,
Inorganic-Zinc
Zineb-ethylene thiuramNA 1465NA 217NA 216FungicideDithiocarbamate,
disulfide adductInorganic-Zinc
Ziram137-30-434805629Fungicide,Dithiocarbamate,
Microbiocide,Inorganic-Zinc
Dog and Cat
Repellent
Zirm, cyclohexylamine16509-79-8348061328Dog and CatDithiocarbamate,
complexRepellent,Inorganic-Zinc
Fungicide
2,2′-Dithiobisbenzothiazole120-78-59202NA 109Fungicide,Mercaptobenzothiazole
Microbiocide,
Insecticide
2-(dithiocyanomethylthio)-NA 1346NA 192NA 191FungicideMercaptobenzothiazole
benzothiazole
2-79910-32-0#####NA 925MicrobiocideMercaptobenzothiazole
(thiocyanomethylthio)benzothiazole
with 2′-hydroxyethyl-2,3-
dibromopropionate
2-Mercaptobenzothiazole149-30-451701556Fungicide,Mercaptobenzothiazole
Microbiocide
2-Mercaptobenzothiazole, 1-5468-43-951702NA 423Fungicide,Mercaptobenzothiazole
(hydroxyethyl)pyridinium saltMicrobiocide
2-Mercaptobenzothiazole,53404-53-851708NA 426Fungicide,Mercaptobenzothiazole
ferric saltMicrobiocide
2-Mercaptobenzothiazole,53404-58-39201NA 108Fungicide,Mercaptobenzothiazole
manganese saltMicrobiocide,
Insecticide
2-Mercaptobenzothiazole,5902-85-251706NA 424Fungicide,Mercaptobenzothiazole
monoethanolammonium saltMicrobiocide
2-Mercaptobenzothiazole,7778-70-351707NA 425Fungicide,Mercaptobenzothiazole
potassium saltMicrobiocide
2-Mercaptobenzothiazole,2492-26-4517043064Microbiocide,Mercaptobenzothiazole
sodium saltFungicide
2-Mercaptobenzothiazole,2492-26-451704613Fungicide,Mercaptobenzothiazole
sodium saltMicrobiocide
2-Mercaptobenzothiazole, zinc155-04-4517051449Fungicide,Mercaptobenzothiazole,
saltMicrobiocideInorganic-Zinc
5-Chloro-2-5331-91-9NA 200NA 199N/AMercaptobenzothiazole
mercaptobenzothiazole
5-Chloro-2-5406-97-3517031238MicrobiocideMercaptobenzothiazole
mercaptobenzothiazole, lauryl
pyridinium salt
5-Chloro-2-5406-97-3NA 4211597Microbiocide,Mercaptobenzothiazole
mercaptobenzothiazole, laurylFungicide
pyridinium salt
5-Chloro-2-53404-93-651709NA 427Microbiocide,Mercaptobenzothiazole,
mercaptobenzothiazole, zincFungicideInorganic-Zinc
salt
TCMTB21564-17-035603971Microbiocide,Mercaptobenzothiazole
Fungicide
Ancymidol12771-68-5#####1744Plant GrowthPyrimidine
Regulator
Bupirimate41483-43-6#####2430FungicidePyrimidine
Cloransulam159518-97-5NA 231NA 231HerbicideTriazolopyrimidine
Cloransulam-methyl147150-35-4#####NA 112HerbicideTriazolopyrimidine
Dimethirimol5221-53-4#####NA 128FungicidePyrimidine
Ethirimol23947-60-6#####NA 129FungicidePyrimidine
Fenarimol60168-88-9#####1980FungicidePyrimidine
Ferimzone89269-64-7NA 203NA 202FungicidePyrimidine
Flurprimidol56425-91-3#####2320Plant GrowthPyrimidine
Regulator
Nuarimol63284-71-9#####NA 126FungicidePyrimidine
Pyrimethanil53112-28-0#####NA 30FungicidePyrimidine
Azoxystrobin131860-33-8#####4037FungicideStrobin
Dimoxystrobin149961-52-4NA 211NA 210FungicideStrobin
Kresoxim-methyl143390-89-0#####5451FungicideStrobin
Metominostrobin133408-50-1NA 211NA 210FungicideStrobin
Picoxystrobin117428-22-5NA 211NA 210FungicideStrobin
Pyraclostrobin175013-18-0NA 211NA 210FungicideStrobin
Trifloxystrobin141517-21-7#####5321FungicideStrobin
chloroneb2675-77-627301135FungicideSubstituted Benzene
Chlorothalonil1897-45-681901677FungicideSubstituted Benzene
Dichlobenil1194-65-627401112HerbicideSubstituted benzene
Dichloran99-30-93130181FungicideSubstituted Benzene
PCNB82-68-856502464Fungicide,Substituted Benzene
Nematicide,
Algaecide
PCNB, other relatedNA 1100NA 16390464Fungicide,Substituted Benzene
Algaecide,
Nematicide
Captafol19044481702NA 787FungicideThiophthalimide
Captafol (cis isomer)2939-80-281701292FungicideThiophthalimide
Captan133-06-281301104FungicideThiophthalimide
Captan, other relatedNA 1074NA 16190104FungicideThiophthalimide
Folpet133-07-381601294FungicideThiophthalimide
Merpafol cis isomer19044481701NA 163FungicideThiophthalimide
Benalaxyl71626-11-4#####NA 102FungicideXylylalanine
Furalaxyl57646-30-7NA 188NA 188FungicideXylylalanine
L-Metalaxyl69516-34-3#####NA 929FungicideXylylalanine
Mefenoxam70630-17-0#####4011FungicideXylylalanine
Mefenoxam, other relatedNA 1152NA 16894011FungicideXylylalanine
Metalaxyl57837-19-1#####2132FungicideXylylalanine
Metalaxyl-M70630-17-0NA 219NA 218FungicideXylylalanine
1-(Alkyl* amino)-3-61791-67-167311NA 586MicrobiocideAlkyl Amino Propane
aminopropane *(47% C12,
18% C14, 10% C18, 9% C10,
8% C16, 8% C8)
1-(Alkyl* amino)-3-61791-63-767301NA 583MicrobiocideAlkyl Amino Propane
aminopropane *(as in fatty
acids of coconut oil)
1-(Alkyl* amino)-3-68911-78-467306NA 585MicrobiocideAlkyl Amino Propane
aminopropane diacetate
*(37% C18′, 29% C16,
23% C18, 3% C16′, 3% C14,
1.5% C18″, 1% C14′, 1% C12,
0.5% C15)
1-(Alkyl* amino)-3-NA 119167313NA 167MicrobiocideAlkyl Amino Propane
aminopropane diacetate *(as in
fatty acids of coconut oil)
1-(Alkyl* amino)-3-NA 119267319NA 167Microbiocide,Alkyl Amino Propane
aminopropane monoacetateAlgaecide
*(47% C12, 18% C14, 10% C18,
9% C10, 8% C16, 8% C8)
1-(Alkyl* amino)-3-NA 119367304NA 167MicrobiocideAlkyl Amino Propane
aminopropane propionate-
copper acetate complex
1-(alkyl-amino)-3-NA 1494NA 221NA 221MicrobiocideAlkyl Amino Propane
aminopropane hydrochloride
1-(alkylamino)-3-68155-37-3673101830MicrobiocideAlkyl Amino Propane
aminopropane
1-(alkylamino)-3-NA 1495NA 221NA 221MicrobiocideAlkyl Amino Propane
carboxymethylaminopropane
1-Alkyl (C6 to C18) amino-3-NA 994NA 7212365MicrobiocideAlkyl Amino Propane
aminopropane acetate
1-alkyl (C6-C18) amino-3-61791-64-8673021954MicrobiocideAlkyl Amino Propane
aminopropane diacetate
1-alkylamino-2-aminopropane61791-64-8673021335MicrobiocideAlkyl Amino Propane
monoacetate, alkyl derived
from coconut oil fatty acids
1-Alkylamino-3-aminopropane68155-43-1673091972Microbiocide,Alkyl Amino Propane
hydroxyacetate, alkyl derivedSoap/Surfactant
from coconut oil fatty acids
Alkyl (53% C12, 19% C14,61791-58-0673051780MicrobiocideAlkyl Amino Propane
8.5% C16, 7% C8, 6.5% C10,
6% C18)-1,3-propane diamine
Alkyl-1,3-propylene diamine61790-63-7NA 5581380Microbiocide,Alkyl Amino Propane
acetate, alkyl derived fromSoap/Surfactant
coconut oil fatty acids
Alkyl-1,3-propylene diamine68155-42-0#####1841Microbiocide,Alkyl Amino Propane
adipate, alkyl derived fromSoap/Surfactant
coconut oil fatty acids
Alkyl-1,3-propylene diamine,NA 287NA 5591379Microbiocide,Alkyl Amino Propane
alkyl derived from coconut oilSoap/Surfactant
fatty acids
N-(2-cyanoethyl)-N-alkyl (C6-C18)-NA 187673211957AdjuvantAlkyl Amino Propane
1,3-diamino propane
N-Alkyl-1,3-propylene diamine68188-29-4673071735Microbiocide,Alkyl Amino Propane
monobenzoate, alkyl derivedSoap/Surfactant
from coconut oil fatty acids
Tall oil fatty acid soap of N-61790-55-4NA 9243463Microbiocide,Alkyl Amino Propane
alkyl (C16-C18) propylInsecticide
diamine
2,2′-Methylenebis(4,6-1940-43-855004NA 455MicrobiocideChlorinated Phenol
dichlorophenol)
2,2′-Thiobis(4,6-97-18-764201NA 539N/AChlorinated Phenol
dichlorophenol)
2,2,2-Trichloro-N-3583-63-9#####NA 151N/AChlorinated Phenol
(pentachlorophenyl)acetimidoyl
chloride
2,2-methylene bis(4,6-68957-70-0550061843MicrobiocideChlorinated Phenol
dichlorophenol), sodium salt
2,3,4,6-tetrachlorophenol,53535-27-6630071725WoodChlorinated phenol
potassium saltPreservative,
Fungicide
2,4,5-trichlorophenol95-95-4642101382Microbiocide,Chlorinated phenol
Algaecide
2,4,5-Trichlorophenol salt of53404-83-464211NA 542N/AChlorinated Phenol
2,6-
bis((dimethylamino)methyl)cyclohexanone
2,4,5-trichlorophenol,35471-43-3642041050MicrobiocideChlorinated phenol
potassium salt
2,4,5-trichlorophenol,NA 1128NA 16691050MicrobiocideChlorinated phenol
potassium salt, other related
2,4,5-trichlorophenol, sodium136-32-3642171656MicrobiocideChlorinated phenol
salt
2,4,5-Trichlorophenol, sodium3784-03-064220NA 545Microbiocide,Chlorinated Phenol
saltAlgaecide
2,4,6-trichlorophenol88-06-264212640MicrobiocideChlorinated phenol
2,4-dichlorophenol120-83-2NA 1052499N/AChlorinated phenol
2-(trichlorophenoxy)ethyl69633-04-1#####NA 152HerbicideChlorinated Phenol
hydrogen sulfate
2-chloro-4-phenylphenol92-04-662206846MicrobiocideChlorinated Phenol
2-chloro-4-phenylphenol,18128-16-0622071061MicrobiocideChlorinated Phenol
potassium salt
2-chloro-4-phenylphenol,31366-97-9622151632MicrobiocideChlorinated Phenol
sodium salt
2-Chlorophenol95-57-862204NA 504MicrobiocideChlorinated Phenol
3-chloro-2-biphenylol, sodium10605-11-562213NA 505MicrobiocideChlorinated Phenol
salt
4 & 6-chloro-2-phenylphenolNA 964NA 4191566MicrobiocideChlorinated Phenol
4 & 6-chloro-2-phenylphenol,NA 965NA 4201604MicrobiocideChlorinated Phenol
potassium salts, mixed
4 & 6-chloro-2-phenylphenol,NA 963NA 4131594MicrobiocideChlorinated Phenol
sodium salts, mixed
4 & 6-chloro-2-phenylphenol,NA 1132NA 16691566MicrobiocideChlorinated phenol
other related
4 or 6-chloro-2-phenylphenol53537-62-562216NA 507MicrobiocideChlorinated Phenol
4 or 6-chloro-2-phenylphenol,53537-63-662214NA 506MicrobiocideChlorinated Phenol
diethanolamine salt
4,6-dichloro-2-phenylphenol5335-24-0642161062MicrobiocideChlorinated phenol
4,6-dichloro-2-phenylphenol,53404-30-1642151059MicrobiocideChlorinated phenol
potassium salt
4-chloro-2-cyclopentyl phenol,35471-38-6642141237Microbiocide,Chlorinated phenol
potassium saltFungicide
4-chloro-2-cyclopentylphenol13347-42-764202836Microbiocide,Chlorinated phenol
Fungicide
4-chloro-2-phenylphenol607-12-562208945MicrobiocideChlorinated Phenol
4-chloro-2-phenylphenol,53404-21-062209947MicrobiocideChlorinated Phenol
potassium salt
4-chloro-2-phenylphenol,10605-10-462212946MicrobiocideChlorinated Phenol
sodium salt
4-chloro-cyclopentylphenol,53404-20-9642181395Microbiocide,Chlorinated phenol
sodium saltFungicide
6-chloro-2-phenylphenol85-97-262210948MicrobiocideChlorinated Phenol
6-chloro-2-phenylphenol,18128-17-162211950MicrobiocideChlorinated Phenol
potassium salt
6-chloro-2-phenylphenol,63992-41-6NA 414949N/AChlorinated phenol
sodium salt
6-chlorothymol89-68-980403NA 775N/AChlorinated Phenol
6-tert-Butyl-4-chloro-m-cresol30894-16-7#####NA 127MicrobiocideChlorinated Phenol
Chlorbisan4418-66-064208127MicrobiocideChlorinated Phenol
Chloroxylenol88-04-086801925MicrobiocideChlorinated phenol
Copper pentachlorophenate15773-35-063011NA 512WoodChlorinated Phenol,
Preservative,Inorganic-Copper
Microbiocide,
Algaecide,
Fungicide
Dehydroabietylamine35109-57-04202NA 72WoodChlorinated Phenol
pentachlorophenatePreservative,
Microbiocide,
Algaecide,
Fungicide
Dichlorophene97-23-455001206Herbicide,Chlorinated Phenol
Fungicide,
Microbiocide
Disodium 2,2′-3247-34-544903NA 380N/AChlorinated Phenol
methylenebis(3,4,6-
trichlorophenate)
Ethylmercury22232-28-641504NA 359MicrobiocideOrganomercury,
pentachlorophenateChlorinated Phenol,
Heavy metal
Fenticlor97-24-564209NA 541MicrobiocideChlorinated Phenol
Hexachlorophene70-30-444901322Microbiocide,Chlorinated Phenol
Fungicide
Hexachlorophene, sodium salt5736-15-244902413MicrobiocideChlorinated Phenol
Ortho-benzyl-para-120-32-162201522Microbiocide,Chlorinated phenol
chlorophenolFungicide
Ortho-benzyl-para-35471-49-962202936MicrobiocideChlorinated phenol
chlorophenol, potassium salt
Ortho-benzyl-para-3184-65-462203937Microbiocide,Chlorinated phenol
chlorophenol, sodium saltFungicide
Para-chloro-meta-cresol59-50-7642061813Microbiocide,Chlorinated Phenol
Fungicide
para-Chloro-ortho-cresol1570-64-562190NA 503N/AChlorinated Phenol
Para-chlorophenol106-48-9NA 1241572N/AChlorinated phenol
PCP87-86-563001465WoodChlorinated Phenol
Preservative,
Microbiocide,
Algaecide,
Fungicide,
Molluscicide,
Herbicide
PCP, other relatedNA 1101NA 16390465WoodChlorinated Phenol
Preservative,
Microbiocide,
Algaecide,
Fungicide,
Molluscicide
PCP, potassium salt7978-73-6630021049WoodChlorinated Phenol
Preservative,
Microbiocide,
Algaecide,
Fungicide,
Molluscicide
PCP, sodium salt131-52-263003540WoodChlorinated Phenol
Preservative,
Microbiocide,
Algaecide,
Fungicide,
Molluscicide
PCP, sodium salt, other relatedNA 1110NA 16490540WoodChlorinated Phenol
Preservative,
Microbiocide,
Algaecide,
Fungicide,
Molluscicide
Pentachlorophenol, zinc salt2917-32-063008NA 510WoodChlorinated Phenol,
Preservative,Inorganic-Zinc
Microbiocide,
Algaecide,
Fungicide
Pentachlorophenyl laurate3772-94-963010NA 511WoodChlorinated Phenol
Preservative,
Microbiocide,
Algaecide,
Fungicide
Potassium 2,2′-67923-62-044904NA 381MicrobiocideChlorinated Phenol
methylenebis(3,4,6-
trichlorophenate)
Potassium 2,4,6-2591-21-164219NA 544MicrobiocideChlorinated Phenol
trichlorophenate
Potassium ortho-cyclopentyl-35471-38-6642141542Microbiocide,Chlorinated phenol
para-chlorophenateFungicide
Sodium 2,2′-methylenebis(4-10254-48-555005NA 456Insecticide,Chlorinated Phenol
chlorophenate)Fungicide,
Microbiocide
Sodium chlorophenates35535-81-062205773N/AChlorinated Phenol
Sodium dichlorophenateNA 1399NA 197NA 196Fungicide,Chlorinated Phenol
Microbiocide
Sodium p-chloro-m-cresolate15733-22-964205NA 540MicrobiocideChlorinated Phenol
Tetrachlorophenol25167-83-363004777WoodChlorinated phenol
Preservative,
Fungicide
Tetrachlorophenol, alkylamineNA 1007NA 9381401WoodChlorinated phenol
saltPreservative,
Fungicide
Tetrachlorophenol, coconutNA 1008NA 9391455WoodChlorinated phenol
amine saltPreservative,
Fungicide
Tetrachlorophenol, otherNA 1118NA 16590777WoodChlorinated phenol
relatedPreservative,
Fungicide
Tetrachlorophenol, potassium53535-27-6630071753WoodChlorinated phenol
saltPreservative,
Fungicide
Tetrachlorophenol, sodium salt25567-55-963005776WoodChlorinated phenol
Preservative,
Fungicide
Tetrachlorophenol, sodium salt,NA 1117NA 16590776WoodChlorinated phenol
other relatedPreservative,
Fungicide
Tetrachlorophenols, alkyl*137543-70-563006NA 509WoodChlorinated Phenol
amine salt *(as in fatty acids ofPreservative,
coconut oil)Fungicide
Trichlorophenol95-95-4642101189Microbiocide,Chlorinated phenol
Algaecide
Trichlorophenol, sodium salt136-32-364217960Microbiocide,Chlorinated phenol
Algaecide
Trichlorophenol, sodium salt,NA 1127NA 16690960MicrobiocideChlorinated phenol
other related
Triclosan3380-34-5549011371MicrobiocideChlorinated Phenol
Vancide 30-R6385-58-664203612MicrobiocideChlorinated Phenol
Zinc 2,4,5-trichlorophenate136-24-364221NA 546N/AChlorinated Phenol,
Inorganic-Zinc
Zinc trichlorophenate30143-22-764213NA 543MicrobiocideChlorinated Phenol,
Inorganic-Zinc
1,3-bis (dihydroxymethyl)-5,5-6440-58-0#####2298Fungicide,Hydantoin
dimethylhydantoinHerbicide,
Microbiocide
1,3-dibromo-5,5-77-48-563174036Microbiocide,Hydantoin
dimethylhydantoinFungicide,
Herbicide
1,3-dichloro-5,5-118-52-52850137Microbiocide,Hydantoin
dimethylhydantoinFungicide,
Herbicide
1,3-Dichloro-5-ethyl-5-89415-87-2#####2264Microbiocide,Hydantoin
methylhydantoinFungicide,
Herbicide
1-bromo-3-chloro-5,5-dimethyl16079-88-263152080Microbiocide,Hydantoin
hydantoinFungicide,
Herbicide
1-Hydroxymethyl-5,5-dimethyl116-25-6#####2306Fungicide,Hydantoin
hydantoinHerbicide,
Microbiocide
3-Bromo-1-chloro-5,5-126-06-76322NA 92Microbiocide,Hydantoin
dimethylhydantoinFungicide,
Herbicide
3-Hydroxymethyl-5,5-dimethylNA 1478NA 220NA 219FungicideHydantoin
hydantoin
Dimethylol dimethyl hydantoin6440-58-0#####2524Fungicide,Hydantoin
Herbicide,
Microbiocide
Acetalized polyvinyl alcoholNA 118546926NA 166MicrobiocideIodine Compound
complexed with iodine
Alkyl (29% C14, 29% C13,NA 973NA 5572063MicrobiocideIodine Compound
21% C12, 21% C15)
poly(oxypropylene) poly
(oxyethylene)-iodine complex
Alkyl (C12-C15)-NA 972NA 5561734MicrobiocideIodine Compound
poly(oxypropylene)
poly(oxyethylene)-iodine
complex
Alkyl(C12-C15)NA 119546918NA 168MicrobiocideIodine Compound
poly(oxypropylene)poly(oxyethylene)-
iodine complex
Alkyl* (ethyl cycloimidinium)NA 121146906NA 169MicrobiocideIodine Compound
3-hydroxy-3-ethyl sodium
alcoholate, 2-methyl sodium
carboxylate-tridecyl
polyoxyethylene ethanol
Alkyl* dimethyl 3,4-NA 119846907NA 168Microbiocide,Iodine Compound,
dichlorobenzyl ammoniumMicrobiocideQuaternary
chlorideAmmonium
polyethoxypolypropoxypolyethoxyethanol-Compound
iodine complex
*(50% C12, 30% C14, 1
Alkyl*NA 121446925NA 170MicrobiocideIodine Compound
poly(oxypropylene)poly(oxyethylene)-
iodine complex
*(43% C10, 30% C14, 12% C12,
10% C16, 5% C18)
Butoxy polypropoxy68610-00-4469011633MicrobiocideIodine Compound
polyethoxy ethanol-iodine
complex
Diethanolamine myristate-53404-40-346910NA 406MicrobiocideIodine Compound
iodine complex
Iodophors39392-86-4NA 213NA 212MicrobiocideIodine Compound
Nonyl phenoxy polyNA 927NA 391610MicrobiocideIodine Compound
(oxyethylene) amine sulfonate
ethanol-iodine
Nonyl phenoxy35860-86-746903870MicrobiocideIodine Compound,
polyoxyethylene ethanol-iodinePolyalkyloxy
complexCompound
Octylphenoxy polyethoxy53404-04-9469152172Microbiocide,Iodine Compound
ethanol-iodine complexFungicide,
Herbicide
Poly oxyethylene ethanol82010-75-1469242261MicrobiocideIodine Compound
monoesters of 5- (and 6-)
carboxy-4-hexyl-2-
cyclohexene-1-octanoic acid,
complex with iodine
Poly propoxy poly ethoxyNA 232NA 4531828MicrobiocideIodine Compound
ethanol, I2 complex
Polyethoxy polypropoxy26617-87-8469041585MicrobiocideIodine Compound
polyethoxy ethanol-iodine
complex
Polyethoxy polypropoxyNA 128646909NA 174MicrobiocideIodine Compound
polyethoxy ethanol-iodine
complex
Polyethoxypolypropoxypolyethoxyethanol-NA 128746913NA 175MicrobiocideIodine Compound,
n-alkyl (54% C12,Quaternary
18% C14, 9% C16, 9% C18,Ammonium
5% C10, 5% C8) di(beta-Compound
hydroxyethyl) benzyl am
Polyethylene glycol ether of68439-47-4469212121MicrobiocideIodine Compound
linear secondary alcohol-
iodine complex
Polyvinyl pyrrolidone-iodine25655-41-8469141611MicrobiocideIodine Compound
complex
Sodium dodecylbenzene53467-01-9469201569MicrobiocideIodine Compound
sulfonate-iodine complex
Sodium N-alkyl-N-palmitoylNA 290NA 5621568MicrobiocideIodine Compound
taurate-iodine complex
Sodium N-cyclohexyl-N-53404-81-2469192089MicrobiocideIodine Compound
palmitoyl taurate-iodine
complex
Tetraglycine hydroperiodide7097-60-1469231923MicrobiocideIodine Compound
Tridecylpoly(ethyleneoxy)ethanol-53404-05-046911NA 407MicrobiocideIodine Compound
iodine complex
Triethanolamine octylsulfate-82010-77-346922NA 409MicrobiocideIodine Compound
iodine complex
2-(4-chlorophenylmethyl)-26530-09-6#####NA 125MicrobiocideIsothiazolone
3(2H)-isothiazolone
2-cyclohexyl-4,5-dichloro-4-57063-29-3#####NA 166InsecticideIsothiazolone
isothiazolin-3-one
2-cyclohexyl-4,5-dichloro-4-57063-29-3#####NA 938InsecticideIsothiazolone
isothioazolin-3-one
2-Methyl-3(2H)-isothiazolone,57373-20-3#####NA 895MicrobiocideIsothiazolone
calcium chloride complex
2-methyl-4,5-trimethylene-4-82633-79-2#####5013MicrobiocideIsothiazolone
isothiazolin-3-one
2-methyl-4-isothiazolin-3-one2682-20-4#####2039MicrobiocideIsothiazolone
3(2H)-chloro-2-methyl-3(2H)-57373-19-0#####NA 894MicrobiocideIsothiazolone
isothiazolone, calcium chloride
complex
4,5-dichloro-2-n-octyl-3(2H)-64359-81-5#####3982Microbiocide,Isothiazolone
isothiazoloneAntifoulant
4-chloro-2-n-octyl-3(2H)-64359-80-4#####NA 102MicrobiocideIsothiazolone
isothiazolone
5-chloro-2-((4-83542-80-7#####NA 125MicrobiocideIsothiazolone
chlorophenyl)methyl)-3(2H)-
isothiazolone, compd. With 2-
((4-chlorophenyl)methyl)-
3(2h)-isothiazolone (1:1)
5-chloro-2-(4-66159-95-3#####NA 125MicrobiocideIsothiazolone
chlorophenylmethyl)-3(2H)-
isothiazolone
5-chloro-2-methyl-4-26172-55-4#####2038MicrobiocideIsothiazolone
isothiazolin-3-one
5-chloro-2-methyl-4-55965-87-2#####NA 896MicrobiocideIsothiazolone
isothiazolin-3-one calcium
chloride with 2-methyl-4-
isothazolin-3-one calcium
chloride
Kathon 886 (kathon biocide)55965-84-9#####NA 24MicrobiocideIsothiazolone
Octhilinone26530-20-1999011881Microbiocide,Isothiazolone
Fungicide
2,4,6-triisopropyl phenol376389NA 1163492N/APhenols
2,4-xylenol105-67-986804638Solvent,Phenols
Fungicide,
Microbiocide
2,6-bis (1-methyl heptadecyl)-5012-62-4NA 1063069MicrobiocidePhenols
p-cresol
2-tert-Amylphenol87-26-364119NA 538MicrobiocidePhenols
4-Hexylresorcinol136-77-671403NA 671N/APhenols
4-Octylresorcinol6565-70-471402NA 670N/APhenols
5-isopropyl-o-cresol499-75-2221041877MicrobiocidePhenols
Butylated hydroxy toluene128-37-0221051309PreservativePhenols
Carbolic acid108-95-264001107Microbiocide,Phenols
Nematicide
Coal tar phenols1319-77-3221011720N/APetroleum derivative,
Phenols
Cresol1319-77-3NA 219NA 218InsectPhenols
Repellent,
Microbiocide
Diisobutyl cresoxy ethoxy53466-87-8691551643MicrobiocidePhenols
ethyl dimethyl benzyl
ammonium chloride-ortho-
phenylphenol ethoxy nonyl
phenol complex
Diisopropyl cresol31291-59-522107NA 176MicrobiocidePhenols
Diisopropyl phenolsNA 170NA 3293638N/APhenols
Hydroxymercury cresol12379-66-746001NA 390MicrobiocideInorganic-Mercury,
Heavy metal, Phenols
Isopropyl cresol499-75-2221041161MicrobiocidePhenols
Isopropyl phenol25168-06-3NA 1553256MicrobiocidePhenols
Meta-cresol108-39-422102378MicrobiocidePhenols
Nonyl phenol25154-52-3NA 443304AdjuvantPhenols
o-cresol95-48-7NA 3743113MicrobiocidePhenols
o-Phenylphenol, alkyl* amine-82010-74-064107NA 533MicrobiocidePhenols, Inorganic-
zinc salt of *(100% C18)Zinc
o-Phenylphenol,53404-71-064109NA 534MicrobiocidePhenols
tetradecylamine salt
Octylphenol27193-28-864118NA 537N/APhenols
Ortho-phenylphenol90-43-764103448MicrobiocidePhenols
Ortho-phenylphenol,52704-98-064116890MicrobiocidePhenols
ammonium salt
Ortho-phenylphenol, potassium13707-65-864108935MicrobiocidePhenols
salt
Ortho-phenylphenol, sodium132-27-464104248MicrobiocidePhenols
salt
p-cresol106-44-5NA 3753114MicrobiocidePhenols
p-Cresyl acetate140-39-6NA 186NA 186MicrobiocidePhenols
Para-tert-amylphenol80-46-664101900MicrobiocidePhenols
Para-tert-amylphenol,53404-18-5641111056MicrobiocidePhenols
potassium salt
Para-tert-butylphenol98-54-4641131000MicrobiocidePhenols
Phenol, dodecyl-, mixed27193-86-8NA 6563323N/APhenols
isomers
Phenol, ferrous saltNA 686NA 1261862N/APhenols
Phenols64743-03-9NA 189NA 189Microbiocide,Phenols
Herbicide
Polyvinylpyrrolidone-53403-98-864110NA 535MicrobiocidePhenols
orthophenylphenol complex
Propoxur phenol4812-20-8#####NA 118BreakdownPhenols
product
Resorcinol108-46-3714013375N/APhenols
Sodium cresolate34689-46-8#####NA 142MicrobiocidePhenols
Sodium para-tert-amylphenate31366-95-7641121541Microbiocide,Phenols
Fungicide
Sodium para-tert-butylphenate5787-50-8641151540MicrobiocidePhenols
Sodium phenate139-02-6640022164MicrobiocidePhenols
Thymol89-83-880402991DyePhenols
Xylenol (unspec. Or mixed1300-71-686805NA 837N/APhenols
from 086804)
2-(2-(p-(diisobutyl) phenoxy)121-54-06912266MicrobiocideQuaternary
ethoxy) ethyl dimethylAmmonium
ammonium chlorideCompound
2-(2-(p-(diisobutyl) phenoxy)121-54-069164NA 166MicrobiocideQuaternary
ethoxy) ethyl dimethylAmmonium
ammonium chlorideCompound
3-(trimethoxysilyl) propyl27668-52-6#####2127MicrobiocideQuaternary
dimethyl octadecyl ammoniumAmmonium
chlorideCompound
3-alkoxy (C12-C15)-2-68187-63-3#####2020N/AQuaternary
hydroxypropyl trimethylAmmonium
ammonium chlorideCompound
Acylamido alkylbenzylNA 993NA 7051442Algaecide,Quaternary
dimethyl ammonium chlorideMicrobiocideAmmonium
Compound
Alkenyl (90% C18, 10% C16)NA 1313NA 1231243Microbiocide,Quaternary
dimethyl ethyl ammoniumAdjuvantAmmonium
bromideCompound
Alkenyl* dimethyl ethyl6458-13-569102NA 620Algaecide,Quaternary
ammonium bromideMicrobiocideAmmonium
*(90% C18′, 10% C16′)Compound
Alkenyl* dimethyl ethylNA 118769198NA 167MicrobiocideQuaternary
ammonium bromideAmmonium
*(90% C18′, 10% C16′)Compound
Alkyl (100% C14) dimethyl139-08-2691072373Algaecide,Quaternary
benzyl ammonium chlorideMicrobiocideAmmonium
Compound
Alkyl (47% C12, 18% C14,NA 986691431970Algaecide,Quaternary
10% C18, 10% C16, 15% C8-C10)MicrobiocideAmmonium
dimethylbenzylCompound
ammonium chloride
Alkyl (50% C12, 30% C14,8023-53-8691102027Algaecide,Quaternary
17% C16, 3% C18) dimethylMicrobiocideAmmonium
dichlorobenzyl ammoniumCompound
chloride
Alkyl (50% C12, 30% C14,NA 987691431850Algaecide,Quaternary
17% C16, 3% C18)MicrobiocideAmmonium
dimethylbenzyl ammoniumCompound
chloride
Alkyl (50% C12, 30% C14,8045-21-4691111849Algaecide,Quaternary
17% C16, 3% C18)MicrobiocideAmmonium
dimethylethylbenzylCompound
ammonium chloride
Alkyl (50% C14, 40% C12,NA 988691431846Algaecide,Quaternary
10% C16) dimethylbenzylMicrobiocideAmmonium
ammonium chlorideCompound
Alkyl (50% C14, 40% C12,68989-01-569171324Algaecide,Quaternary
10% C16) dimethylbenzylMicrobiocideAmmonium
ammonium saccharinateCompound
Alkyl (53% C12, 19% C14,61789-71-7691403535Algaecide,Quaternary
8.5% C16, 7% C8, 6.5% C10,MicrobiocideAmmonium
6% C18) dimethylCompound
benzylammonium chloride
Alkyl (58% C14, 28% C16,NA 989691431912Algaecide,Quaternary
14% C12) dimethylbenzylMicrobiocideAmmonium
ammonium chlorideCompound
Alkyl (58% C18, 40% C16,68391-03-7691632228MicrobiocideQuaternary
1% C14, 1% C12) trimethylAmmonium
ammonium chlorideCompound
Alkyl (60% C14, 25% C12,68424-85-1691051956Algaecide,Quaternary
15% C16) dimethylbenzylMicrobiocideAmmonium
ammonium chlorideCompound
Alkyl (60% C14, 30% C16,NA 976691431847Algaecide,Quaternary
5% C12, 5% C18)MicrobiocideAmmonium
dimethylbenzyl ammoniumCompound
chloride
Alkyl (61% C12, 23% C14,68989-00-4#####1960Algaecide,Quaternary
11% C16, 3% C10, 2% C8)MicrobiocideAmmonium
dimethylbenzyl ammoniumCompound
chloride
Alkyl (61% C12, 23% C14,NA 977691431975Algaecide,Quaternary
11% C16, 5% C18) dimethylMicrobiocideAmmonium
benzyl ammonium chlorideCompound
Alkyl (61% C12, 23% C14,NA 978691432060Algaecide,Quaternary
11% C16, 5% C8, C10, C18)MicrobiocideAmmonium
dimethylbenzyl ammoniumCompound
chloride
Alkyl61789-71-7691402375Algaecide,Quaternary
(61% C12, 23% C14, 11% C16, 2.5%MicrobiocideAmmonium
C8 & C10, 2.5% C18)Compound
dimethyl benzyl ammonium
chloride
Alkyl (65% C12, 25% C14,NA 979691431971Algaecide,Quaternary
10% C16) dimethylbenzylMicrobiocideAmmonium
ammonium chlorideCompound
Alkyl (67% C12, 25% C14,NA 980691431853Algaecide,Quaternary
7% C16, 1% C8, C10, C18)MicrobiocideAmmonium
dimethylbenzyl ammoniumCompound
chloride
Alkyl (68% C12, 32% C14)NA 1190#####NA 167Algaecide,Quaternary
dimethyl dimethylbenzylMicrobiocideAmmonium
ammonium chlorideCompound
Alkyl (68% C12, 32% C14)85409-23-0691541854Algaecide,Quaternary
dimethylethylbenzylFungicide,Ammonium
ammonium chlorideMicrobiocideCompound
Alkyl (70% C18, 27% C16,68391-03-76916310MicrobiocideQuaternary
3% C14) trimethyl ammoniumAmmonium
chlorideCompound
Alkyl (90% C14, 5% C12,8023-53-8691101909Algaecide,Quaternary
5% C16) dimethylMicrobiocideAmmonium
dichlorobenzyl ammoniumCompound
chloride
Alkyl (90% C14, 5% C12,68527-84-4691462057Algaecide,Quaternary
5% C16) dimethyl ethylMicrobiocideAmmonium
ammonium bromideCompound
Alkyl (90% C14, 5% C12,NA 981691431977Algaecide,Quaternary
5% C16) dimethylbenzylMicrobiocideAmmonium
ammonium chlorideCompound
Alkyl (93% C14, 4% C12,NA 1031691431991Algaecide,Quaternary
3% C16) dimethylbenzylMicrobiocideAmmonium
ammonium chlorideCompound
Alkyl (95% C14, 3% C12,68424-85-1691053855Algaecide,Quaternary
2% C16) dimethyl benzylMicrobiocideAmmonium
ammonium chlorideCompound
Alkyl (95% C14, 3% C12,NA 982691842152Algaecide,Quaternary
2% C16) dimethyl benzylMicrobiocideAmmonium
ammonium chloride dihydrateCompound
Alkyl (95% C14, 3% C12,NA 1322NA 5833897Algaecide,Quaternary
2% C16) dimethyl benzylMicrobiocideAmmonium
ammonium chlorideCompound
monohydrate
Alkyl (98% C12, 2% C14)53516-75-9691121839Algaecide,Quaternary
dimethyl 1-naphthylmethylMicrobiocideAmmonium
ammonium chlorideCompound
Alkyl (C10-16) dimethyl amine61788-90-7NA 4013896Algaecide,Quaternary
oxideMicrobiocideAmmonium
Compound
Alkyl (C14, C12, C16)NA 985NA 5872374Algaecide,Quaternary
dimethyl benzyl ammoniumMicrobiocideAmmonium
chlorideCompound
Alkyl (C8-C18) bis (2-61789-68-2#####2031MicrobiocideQuaternary
hydroxyethyl) benzylAmmonium
ammonium chlorideCompound
Alkyl (C8-C18) bis (2-NA 119669148NA 168Algaecide,Quaternary
hydroxyethyl) benzylMicrobiocideAmmonium
ammonium chlorideCompound
Alkyl dimethyl cumenylNA 983NA 5841919Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
Compound
Alkyl dimethyl ethyl benzylNA 974NA 5801002MicrobiocideQuaternary
ammonium cyclohexylAmmonium
sulfonateCompound
Alkyl dimethyl ethylbenzyl71808-54-3691351722Algaecide,Quaternary
ammonium cyclohexylMicrobiocideAmmonium
sulfamateCompound
Alkyl dimethyl isopropylNA 97569188884MicrobiocideQuaternary
benzyl ammonium chlorideAmmonium
Compound
Alkyl monoethyoxyethanol,NA 305NA 5771045MicrobiocideQuaternary
diethoxyethyl benzylAmmonium
ammonium chlorideCompound
Alkyl morpholiniumNA 1523NA 223NA 223FungicideQuaternary
ethosulphate (1% C14, 22%Ammonium
C16, 77% C18)Compound
Alkyl trimethyl ammonium68424-92-0#####1827MicrobiocideQuaternary
bromidesAmmonium
Compound
Alkyl(68% C12,NA 1068NA 1595126AlgaecideQuaternary
32% C14)dimethylAmmonium
dimethylbenzyl ammoniumCompound
chloride
Alkyl* bis(2-91721-81-2#####NA 113N/AQuaternary
hydroxyethyl)benzylAmmonium
ammonium chlorideCompound
*(57% C10, 20% C12, 11% C14,
9% C18, 2% C16, 1% C8)
Alkyl* dimethyl 3,4-NA 1197#####NA 168Algaecide,Quaternary
dichlorobenzyl ammoniumMicrobiocideAmmonium
chloride *(42% C12, 27% C14,Compound
13% C16, 18% C8-C18)
Alkyl* dimethyl 3,4-68989-02-6#####NA 112Algaecide,Quaternary
dichlorobenzyl ammoniumMicrobiocideAmmonium
chloride *(50% C14, 40% C12,Compound
10% C16)
Alkyl* dimethyl 3,4-92129-28-769182NA 648Algaecide,Quaternary
dichlorobenzyl ammoniumMicrobiocideAmmonium
chloride *(55% C14, 23% C12,Compound
20% C16, 2% C18)
Alkyl* dimethyl 3,4-68989-02-6#####NA 124Algaecide,Quaternary
dichlorobenzyl ammoniumMicrobiocideAmmonium
chloride *(60% C14, 30% C16,Compound
10% C12)
Alkyl* dimethyl 3,4-68989-02-669180NA 646Algaecide,Quaternary
dichlorobenzyl ammoniumMicrobiocideAmmonium
chloride *(60% C12, 25% C14,Compound
15% C16)
Alkyl* dimethyl 3,4-68989-02-6#####NA 113Algaecide,Quaternary
dichlorobenzyl ammoniumMicrobiocideAmmonium
chloride *(63% C12, 23% C14,Compound
14% C16)
Alkyl* dimethyl 3,4-92129-28-769196NA 653Algaecide,Quaternary
dichlorobenzyl ammoniumMicrobiocideAmmonium
chloride *(65% C12, 22% C14,Compound
10% C16, 3% C18)
Alkyl* dimethyl 3,4-68989-02-6#####NA 114Algaecide,Quaternary
dichlorobenzyl ammoniumMicrobiocideAmmonium
chloride *(68% C12, 27% C14,Compound
5% C16)
Alkyl* dimethyl 3,4-68568-47-8#####NA 124Algaecide,Quaternary
dichlorobenzyl ammoniumMicrobiocideAmmonium
chloride *(75% C12, 25% C14)Compound
Alkyl* dimethyl 3,4-68989-02-6#####NA 124Algaecide,Quaternary
dichlorobenzyl ammoniumMicrobiocideAmmonium
chloride *(75% C12, 25% C14)Compound
Alkyl* dimethyl 3,4-68989-02-669145NA 635Algaecide,Quaternary
dichlorobenzyl ammoniumMicrobiocideAmmonium
chloride *(90% C14, 5% C16,Compound
5% C12)
Alkyl* dimethyl 3,4-68989-02-6#####NA 115Algaecide,Quaternary
dichlorobenzyl ammoniumMicrobiocideAmmonium
chloride *(C12 65%, C14 25%,Compound
C16 10%)
Alkyl* dimethyl 3,4-NA 119846907NA 168Microbiocide,Iodine Compound,
dichlorobenzyl ammoniumMicrobiocideQuaternary
chlorideAmmonium
polyethoxypolypropoxypolyethoxyethanol-Compound
iodine complex
*(50% C12, 30% C14, 1
Alkyl* dimethyl benzyl71011-24-0#####NA 113Algaecide,Quaternary
ammonium bentonite *(as inMicrobiocideAmmonium
fatty acids of tallow)Compound
Alkyl* dimethyl benzyl122-18-969108NA 623Algaecide,Quaternary
ammonium chloride *(100%MicrobiocideAmmonium
C16)Compound
Alkyl* dimethyl benzyl122-19-0#####NA 114Algaecide,Quaternary
ammonium chloride *(100%MicrobiocideAmmonium
C18)Compound
Alkyl* dimethyl benzyl68391-01-569195NA 652Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
*(41% C14, 28% C12, 19% C18,Compound
12% C16)
Alkyl* dimethyl benzylNA 119969168NA 168Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
*(47% C12, 18% C14, 15%(C5-C15),Compound
10% C18, 10% C16)
Alkyl* dimethyl benzyl8001-54-569106NA 622Microbiocide,Quaternary
ammonium chlorideAlgaecide,Ammonium
*(50% C12, 30% C14, 17% C16,HerbicideCompound
3% C18)
Alkyl* dimethyl benzyl68391-01-5#####NA 113Algaecide,Quaternary
ammonium chloride *(55%MicrobiocideAmmonium
C16, 27% C12, 16% C14, 2%Compound
C18)
Alkyl* dimethyl benzyl68391-01-569169NA 641Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
*(55% C16, 20% C14, 20% C12,Compound
5% C18)
Alkyl* dimethyl benzylNA 120069141NA 168Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
*(58% C14, 28% C16, 14% C12)Compound
Alkyl* dimethyl benzyl68424-85-169161NA 168Algaecide,Quaternary
ammonium chloride *(60%MicrobiocideAmmonium
C14, 30% C16, 10% C12)Compound
Alkyl* dimethyl benzylNA 120169137NA 168Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
*(60% C14, 25% C12, 15% C16)Compound
Alkyl* dimethyl benzyl53516-76-069104NA 621Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
*(60% C14, 30% C16, 5% C18,Compound
5% C12)
Alkyl* dimethyl benzyl68391-01-569189NA 650Algaecide,Quaternary
ammonium chloride *(61%MicrobiocideAmmonium
C12, 23% C14, 11% C16, 5%Compound
C18)
Alkyl* dimethyl benzylNA 1202#####NA 168Algaecide,Quaternary
ammonium chloride *(61%MicrobiocideAmmonium
C12, 23% 014, 11% C16, 5%Compound
C18)
Alkyl* dimethyl benzylNA 120369199NA 169Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
*(65% C12, 23% C14, 12% C16)Compound
Alkyl* dimethyl benzyl68424-85-169157NA 164Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
*(65% C12, 25% C14, 10% C16)Compound
Alkyl* dimethyl benzyl68391-01-569175NA 644Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
*(67% C12, 25% C14, 7% C16,Compound
1% C18)
Alkyl* dimethyl benzylNA 1204#####NA 169Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
*(67% C12, 25% C14, 7% C16,Compound
1% C8, C10, and C18)
Alkyl* dimethyl benzylNA 120569142NA 169MicrobiocideQuaternary
ammonium chlorideAmmonium
*(67% C12, 27% C14, 6% C16)Compound
Alkyl* dimethyl benzylNA 1206#####NA 169Algaecide,Quaternary
ammonium chloride *(68%MicrobiocideAmmonium
C12, 25% C14, 7% C16)Compound
Alkyl* dimethyl benzylNA 120769194NA 169Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
*(90% C14, 5% C12, 5% C16)Compound
Alkyl* dimethyl benzyl68424-85-169158NA 164Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
*(93% C14, 4% C12, 3% C16)Compound
Alkyl* dimethyl benzyl68607-20-5#####NA 114Algaecide,Quaternary
ammonium chloride *(95%MicrobiocideAmmonium
C16, 5% C18)Compound
Alkyl* dimethyl benzylNA 1208#####NA 169Algaecide,Quaternary
ammonium chloride *(as inMicrobiocideAmmonium
fatty acids of coconut oil)Compound
Alkyl* dimethyl benzylNA 1209#####NA 169Algaecide,Quaternary
ammonium chloride *(C8-18)MicrobiocideAmmonium
Compound
Alkyl* dimethyl benzyl61790-41-8#####NA 114Algaecide,Quaternary
ammonium ion alkyl** amineMicrobiocideAmmonium
*(C12, C14, C16) **(C10,Compound
C12, C14, C16)
Alkyl* dimethyl8045-22-569109NA 624Algaecide,Quaternary
dimethylbenzyl ammoniumMicrobiocideAmmonium
chloride *(50% C12, 30% C14,Compound
17% C16, 3% C18)
Alkyl* dimethyl ethyl134595-54-369186NA 649Algaecide,Quaternary
ammonium bromide *(85%MicrobiocideAmmonium
C16, 15% C18)Compound
Alkyl* dimethyl ethyl61788-99-6#####NA 113Algaecide,Quaternary
ammonium bromide *(mixedMicrobiocideAmmonium
alkyl and alkenyl groups as inCompound
fatty acids of soybean oil)
Alkyl* dimethyl ethylbenzyl68956-79-669167NA 640Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
*(60% C14, 30% C16, 5% C12,Compound
5% C18)
Alkyl* dimethyl ethylbenzyl37335-68-569135NA 633Algaecide,Quaternary
ammoniumMicrobiocideAmmonium
cyclohexylsulfamateCompound
*(50% C12, 30% C14, 17% C16,
3% C18)
Alkyl* trimethyl ammonium1119-97-769153NA 637MicrobiocideQuaternary
bromide *(95% C14, 5% C16)Ammonium
Compound
Alkyl* trimethyl ammonium112-00-5#####NA 113MicrobiocideQuaternary
chloride *(70% C12, 30% C14)Ammonium
Compound
Alkyl* trimethyl ammonium68002-63-169197NA 654MicrobiocideQuaternary
chloride *(70% C18, 27% C16,Ammonium
3% C14)Compound
Alkyl* trimethyl ammonium68002-62-069151NA 636MicrobiocideQuaternary
chloride *(90% C18, 10% C16)Ammonium
Compound
Alkyl* trimethyl ammonium61790-41-8#####NA 115MicrobiocideQuaternary
chloride *(alkyl as in fattyAmmonium
acids of soybean oil)Compound
Alkyl* trimethyl ammonium61789-18-2#####NA 109MicrobiocideQuaternary
chloride *(as in fatty acids ofAmmonium
coconut oil)Compound
Alkyl* trimethyl ammonium68002-61-969139NA 634MicrobiocideQuaternary
chloride *derived fromAmmonium
cottonseed oilCompound
Alkyl*-5-hydroxy-4-oxo-NA 1189#####NA 167MicrobiocideQuaternary
2(4H)-pyranylmethyl dimethylAmmonium
ammonium chloride *(49%Compound
C12, 17% C14, 17% C10, 10%
C18, 9% C16, 8% C8)
Alkyl*-N,N-bis(2-70750-47-9#####NA 114N/AQuaternary
hydroxyethyl)methylAmmonium
ammonium chloride *(53%Compound
C12, 19% C14, 8.5% C16,
7.0% C8, 6.5% C10, 6.0%
C18)
Alkyl*-N-ethyl morpholiniumNA 121369147NA 170Fungicide,Quaternary
ethyl sulfate *(66% C18,AlgaecideAmmonium
25% C16, 8% C18′, 1% C14)Compound
AlkyldimethylbenzylNA 1368NA 194NA 193Microbiocide,Quaternary
ammonium chlorideHerbicideAmmonium
Compound
AlkyldimethylethylbenzylammoniumNA 1369NA 194NA 193Microbiocide,Quaternary
chlorideHerbicideAmmonium
Compound
Alkyltrimethyl ammoniumNA 1370NA 194NA 193Microbiocide,Quaternary
chlorideFungicideAmmonium
Compound
AlkyltrimethylbenzylNA 1371NA 194NA 193HerbicideQuaternary
ammonium chlorideAmmonium
Compound
Benzyl dimethyl octadecyl122-19-0#####1186MicrobiocideQuaternary
ammonium chlorideAmmonium
Compound
Benzyl((dodecylcarbamoyl)methyl)100-95-869159NA 638MicrobiocideQuaternary
dimethyl ammoniumAmmonium
chlorideCompound
Benzyl-C12-14-alkyldimethyl134058-54-1691925069MicrobiocideQuaternary
quaternary ammoniumAmmonium
compoundsCompound
Cetyl dimethyl ethyl124-03-869156122MicrobiocideQuaternary
ammonium bromideAmmonium
Compound
Cetyl trimethyl ammonium57-09-069117116Microbiocide,Quaternary
bromideHerbicideAmmonium
Compound
Cetyl trimethyl ammonium112-02-769133NA 632MicrobiocideQuaternary
chlorideAmmonium
Compound
Cetylcide (95% C16, 3% C14,124-03-8691562061MicrobiocideQuaternary
2% C12)Ammonium
Compound
Chlormequat7003-89-6NA 216NA 215Plant GrowthQuaternary
RegulatorAmmonium
Compound
Chlormequat chloride999-81-5181011512Plant GrowthQuaternary
RegulatorAmmonium
Compound
Di(alkyl* oxypropyl)dimethylNA 126169121NA 173Algaecide,Quaternary
ammonium chloride *(60% C8,MicrobiocideAmmonium
40% C10)Compound
Dialkyl (85% C18, 15% C16)68514-95-4NA 355197Microbiocide,Quaternary
dimethyl ammonium chlorideAdjuvantAmmonium
Compound
Dialkyl dimethyl ammoniumNA 900NA 1725181MicrobiocideQuaternary
polynaphthyl amineAmmonium
Compound
Dialkyl* dimethyl ammonium73398-64-8691362230MicrobiocideQuaternary
chloride *(47% C12, 18% C14,Ammonium
10% C18, 9% C10, 8% C16,Compound
8% C8)
Dialkyl* dimethyl ammonium73398-64-8#####NA 114MicrobiocideQuaternary
chloride *(48% C12, 17% C14,Ammonium
10% C18, 9% C16, 8% C8, 7%Compound
C10, 1% C6)
Dialkyl* dimethyl ammonium68153-33-3#####NA 113MicrobiocideQuaternary
chloride *(50% C12, 20% C14,Ammonium
15% C10, 10% C16, 5% C18)Compound
Dialkyl* dimethyl ammonium68910-56-569177NA 645MicrobiocideQuaternary
chloride *(50% C12, 30% C14,Ammonium
20% C16)Compound
Dialkyl* dimethyl ammonium68002-59-569120NA 626MicrobiocideQuaternary
chloride *(70% C18, 26% C16,Ammonium
4% C14)Compound
Dialkyl* methyl benzyl73049-75-969119NA 625Algaecide,Quaternary
ammonium chloride *(60%MicrobiocideAmmonium
C14, 30% C16, 5% C18, 5%Compound
C12)
Diallyl dimethyl ammonium26062-79-3#####5092AdjuvantQuaternary
chloride polymersAmmonium
Compound
DibenzyldimethylammoniumNA 1440NA 213NA 213MicrobiocideQuaternary
chlorideAmmonium
Compound
Dicoco dimonium chloride61789-77-3691383140AdjuvantQuaternary
Ammonium
Compound
Didecyl dimethyl ammonium148788-55-069208NA 658MicrobiocideQuaternary
carbonate and didecyl dimethylAmmonium
ammonium bicarbonateCompound
Didecyl dimethyl ammonium148812-65-169208NA 659MicrobiocideQuaternary
carbonate and didecyl dimethylAmmonium
ammonium bicarbonateCompound
Didecyl dimethyl ammonium7173-51-5691491682Microbiocide,Quaternary
chlorideFungicideAmmonium
Compound
Didecyl methyl benzyl32426-10-169170NA 642MicrobiocideQuaternary
ammonium chlorideAmmonium
Compound
Dihydrogenated tallow61789-81-9691503153AdjuvantQuaternary
dimethyl ammoniumAmmonium
methosulfateCompound
Dilauryl dimethyl ammonium3282-73-3#####NA 112MicrobiocideQuaternary
bromideAmmonium
Compound
Dimethyl dicoco ammoniumNA 166NA 3171945MicrobiocideQuaternary
chlorideAmmonium
Compound
Dimethyl dioctadecylNA 627NA 1143163AdjuvantQuaternary
ammonium bentoniteAmmonium
Compound
Dioctyl dimethyl ammonium5538-94-3691661710Microbiocide,Quaternary
chlorideAlgaecide,Ammonium
FungicideCompound
Distearyl dimonium chloride107-64-2#####3176AdjuvantQuaternary
Ammonium
Compound
Dodecyl di(2-hydroxyethyl)19379-90-969181NA 647MicrobiocideQuaternary
benzyl ammonium chlorideAmmonium
Compound
Dodecyl dimethyl 2,4,5-53404-46-9#####NA 113MicrobiocideQuaternary
trimethylbenzyl ammoniumAmmonium
chlorideCompound
Dodecyl dimethyl ammoniumNA 157NA 2941008MicrobiocideQuaternary
chlorideAmmonium
Compound
Dodecyl dimethyl benzyl196400169123NA 627Fungicide,Quaternary
ammonium bromideMicrobiocideAmmonium
Compound
Dodecyl dimethyl benzyl139-07-1691241167Microbiocide,Quaternary
ammonium chlorideHerbicideAmmonium
Compound
Dodecyl dimethyl benzyl22232-26-469128NA 629MicrobiocideQuaternary
ammoniumAmmonium
cyclopentanecarboxylateCompound
Dodecyl dimethyl benzylNA 1027691271446Fungicide,Quaternary
ammonium naphthenateInsecticide,Ammonium
FungicideCompound
Dodecyl dimethyl53466-90-3#####NA 113MicrobiocideQuaternary
trichlorobenzyl ammoniumAmmonium
chlorideCompound
Dodecylbenzyl alkyl (70% C12,87175-02-8#####1038Algaecide,Quaternary
30% C14) dimethyl ammoniumMicrobiocideAmmonium
chlorideCompound
Dodecylbenzyl octadecyl29932-85-2#####NA 113MicrobiocideQuaternary
dimethyl ammonium chlorideAmmonium
Compound
Dodecylbenzyl trimethyl12379-51-069126NA 628N/AQuaternary
ammonium 2-ethylhexanoateAmmonium
Compound
Dodecylbenzyl trimethyl1330-85-469125918Adjuvant,Quaternary
ammonium chlorideMicrobiocideAmmonium
Compound
EcolystNA 117469089NA 165Plant GrowthQuaternary
RegulatorAmmonium
Compound
Ethyl dimethyl stearyl111-98-8#####NA 115MicrobiocideQuaternary
ammonium bromideAmmonium
Compound
Mepiquat15302-91-7NA 203NA 202Plant GrowthQuaternary
RegulatorAmmonium
Compound
Mepiquat chloride24307-26-4#####2075Plant GrowthQuaternary
RegulatorAmmonium
Compound
Methyl dodecyl benzyl1399-80-069129895MicrobiocideQuaternary
trimethyl ammonium chlorideAmmonium
Compound
Methyl dodecyl benzylNA 619NA 1122678MicrobiocideQuaternary
trimethyl ammonium chlorideAmmonium
80% and methylCompound
Methyl dodecyl trimethylNA 44NA 832679MicrobiocideQuaternary
ammonium chlorideAmmonium
Compound
Methyl dodecyl xylene bisNA 45NA 84896MicrobiocideQuaternary
(trimethyl ammonium chloride)Ammonium
Compound
Methyl trioctyl ammonium5137-55-3NA 723291AdjuvantQuaternary
chlorideAmmonium
Compound
Morpholine dodecyl benzene12068-08-5#####3294Microbiocide,Quaternary
sulfonateAdjuvant,Ammonium
Fungicide,Compound
Insecticide
N-(3,4-dichlorobenzyl)-N-102-30-7#####1129MicrobiocideQuaternary
dodecyl-N,N-dimethylAmmonium
ammonium chlorideCompound
N-alkyl (92% C18, 8% C16)-N-61791-34-269113986Fungicide,Quaternary
ethyl morpholinium ethylMicrobiocideAmmonium
sulfateCompound
N-alkyl (soza)-N-methylNA 281NA 5503020Fungicide,Quaternary
morpholinium sulfateMicrobiocideAmmonium
Compound
N-cetyl-N-ethyl morpholinium78-21-7691131792Fungicide,Quaternary
ethyl sulfateMicrobiocideAmmonium
Compound
N-Cetyl-N-ethyl morpholinium78-21-7#####NA 174FungicideQuaternary
ethyl sulfateAmmonium
Compound
N-Cetyl-N-ethylmorpholinium78-21-769187NA 172FungicideQuaternary
ethyl sulfateAmmonium
Compound
N-Dialkyl (60% C14, 30% C16,68424-87-3NA 3562070MicrobiocideQuaternary
5% C12, 5% C18) methylAmmonium
benzyl ammonium chlorideCompound
N-isononyl-N,N-dimethyl138698-36-9692075070MicrobiocideQuaternary
decanaminium chlorideAmmonium
Compound
Octyl decyl dimethyl32426-11-2691651709Microbiocide,Quaternary
ammonium chlorideFungicideAmmonium
Compound
Octyl dodecyl dimethyl10361-16-7691901947MicrobiocideQuaternary
ammonium chlorideAmmonium
Compound
Oleyl dimethyl ethyl14351-44-169132NA 631MicrobiocideQuaternary
ammonium bromideAmmonium
Compound
Oxydiethylene bis (alkyl68607-28-3691731362MicrobiocideQuaternary
dimethyl ammonium chloride),Ammonium
alkyl derived from coconut oilCompound
fatty acids
Polybromide form ofNA 11648711NA 163MicrobiocideQuaternary
trimethylbenzyl ammoniumAmmonium
resinCompound
Polyethoxypolypropoxypolyethoxyethanol-NA 128746913NA 175MicrobiocideIodine Compound,
n-alkyl (54% C12,Quaternary
18% C14, 9% C16, 9% C18,Ammonium
5% C10, 5% C8) di(beta-Compound
hydroxyethyl) benzyl am
Polymeric quaternaryNA 1463NA 217NA 216Microbiocide,Quaternary
ammonium chlorideAdjuvantAmmonium
Compound
Polyquaternium-628301-34-0NA 7672818AdjuvantQuaternary
Ammonium
Compound
Polytrimethyl vinyl benzyl9017-80-5NA 1193769AdjuvantQuaternary
ammonium chlorideAmmonium
Compound
Quaternium-18 bentonite68953-58-2#####2996AdjuvantQuaternary
Ammonium
Compound
Soya ethyl morpholinium61791-34-2691133453Fungicide,Quaternary
ethosulfateMicrobiocideAmmonium
Compound
Tetradecyl dimethyl benzyl139-08-2691071166Algaecide,Quaternary
ammonium chlorideMicrobiocideAmmonium
Compound
Tetraethyl ammonium77-98-54215NA 76N/AQuaternary
hydroxideAmmonium
Compound
2-Mercaptobenzothiazole, zinc155-04-4517051449Fungicide,Mercaptobenzothiazole,
saltMicrobiocideInorganic-Zinc
5-Chloro-2-53404-93-651709NA 427Microbiocide,Mercaptobenzothiazole,
mercaptobenzothiazole, zincFungicideInorganic-Zinc
salt
Acetic acid, copper (2+) salt142-71-2NA 6973013N/AInorganic-Copper
Alkyl*-1-(2-aminoethyl)-2-NA 118846606NA 167MicrobiocideInorganic-Nickel,
imidazoline acetate-nickelImidazoline
sulfate complex
Aluminum7429-90-51111042N/AInorganic
Aluminum acetateNA 971NA 5483025N/AInorganic
Aluminum bicarbonateNA 1043NA 1403026N/AInorganic
Aluminum caprylate6028-57-5NA 5493027N/AInorganic
Aluminum chloride7446-70-0139013028N/AInorganic
Aluminum diacetate142-03-0NA 1133029N/AInorganic
Aluminum hydroxide21645-51-2NA 1292145N/AInorganic
Aluminum magnesium silicateNA 1018NA 1072378AdjuvantInorganic
Aluminum oxide1344-28-1NA 5403030N/AInorganic
Aluminum phosphide20859-73-866501484Fumigant,Inorganic
Fungicide,
Fungicide
Aluminum potassium sulfate10043-67-1#####3031Herbicide,Inorganic
Insecticide
Aluminum silicate1302-76-7NA 1312379AdjuvantInorganic
Aluminum stearate637-12-7NA 5413032N/AInorganic
Aluminum sulfate10043-01-3139061415Plant GrowthInorganic
Regulator,
Molluscicide
Ammonia7664-41-7530222Insecticide,Inorganic
Deer Repellent,
Fungicide
Ammonium alum7784-26-1NA 5333037RepellentInorganic
Ammonium alumNA 121698501NA 170AdjuvantInorganic
Ammonium arsenate7784-44-3136012380Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Ammonium bicarbonate1066-33-7NA 5343038pH AdjustmentInorganic
Ammonium bisulfate7803-63-6NA 1413039N/AInorganic
Ammonium bromide12124-97-93523040N/AInorganic
Ammonium carbamate1111-89-7NA 1413041N/AInorganic
Ammonium carbonate506-87-6735013042Fungicide,Inorganic
Herbicide,
Microbiocide,
pH Adjustment
Ammonium chloride12125-02-9#####3043N/AInorganic
Ammonium dichromate214970168305NA 607WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Ammonium ferric sulfate10138-04-2NA 5373047HerbicideInorganic
Ammonium fluosilicate16919-19-075301695InsecticideInorganic
Ammonium fluosilicate on62449-69-875311NA 694InsecticideInorganic
silica gel
Ammonium hydroxide1336-21-653012381Fungicide, pHInorganic
Adjustment,
Herbicide,
Microbiocide
Ammonium nitrate6484-52-2761013052Rodenticide,Inorganic
Microbiocide
Ammonium nitrite13446-48-576201NA 700Rodenticide,Inorganic
Microbiocide
Ammonium oxalate1113-38-89603891MicrobiocideInorganic
Ammonium polysulfides9080-17-576701NA 707Insecticide,Inorganic
Fungicide
Ammonium sulfate7783-20-256011363Herbicide, pHInorganic
Adjustment
Ammonium thiocyanate1762-95-46820025SynergistInorganic
Ammonium thiosulfate7783-18-880103892Insecticide,Inorganic
Fungicide,
Herbicide
Anhydrous zirconium (IV)1314-23-4790902204N/AInorganic
oxide
Anilinocadmium dilactate19651-91-364601NA 548N/AInorganic-Cadmium,
Heavy metal
Arsenic7440-38-2NA 121710Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic acid7778-39-4680140Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic disulfide56320-22-06901NA 98Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic pentoxide1303-28-26802631Fungicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide,
Herbicide
Arsenic sulfide12612-21-46901NA 99Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic trioxide1327-53-3700142Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic trisulfide1303-33-96901NA 97Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsonic acid, ammonium salt58829-95-1#####NA 105Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Wood
Preservative
Asbestos1332-21-4993012398InsecticideInorganic
Barium carbonate513-77-975013060N/AInorganic
Barium chloride10361-37-2NA 1413061N/AInorganic
Barium fluosilicate17125-80-375302NA 688InsecticideInorganic
Barium metaborate13701-59-211101973FungicideInorganic
Barium nitrate10022-31-8NA 186NA 185RepellentInorganic
Barium polysulfide50864-67-076704NA 709Insecticide,Inorganic
Fungicide
Barium sulfate7727-43-775022411N/AInorganic
Basic copper arsenate16102-92-4#####NA 132Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Copper
Basic lead silicate53466-66-348003NA 417N/AInorganic-Lead,
Heavy metal
Bentonite1302-78-9NA 4961399AdjuvantInorganic
Blast furnace slagNA 239NA 4772425N/AInorganic
Borax1303-96-41110279Insecticide,Inorganic
Herbicide
Bordeaux mixtureNA 240NA 47880FungicideInorganic-Copper
Boric acid10043-35-311001769InsecticideInorganic
Boric acid(H4B6O11), zinc12447-61-9#####5094FungicideInorganic-Zinc
salt(1:2)
Boric oxide1303-86-2110022090InsecticideInorganic
Boron7440-42-8#####2426N/AInorganic
Boron sodium oxide12179-04-311110NA 116InsecticideInorganic
(B4Na2O7), pentahydrate
Bromine7726-95-687012296MicrobiocideInorganic
Bromine chloride13863-41-7205042323MicrobiocideInorganic
Cadmium7440-43-9NA 4602438N/AInorganic-Cadmium,
Heavy metal
Cadmium carbonate513-78-01290193N/AInorganic-Cadmium,
Heavy metal
Cadmium chloride10108-64-21290294N/AInorganic-Cadmium,
Heavy metal
Cadmium cocoate72869-63-7NA 4593085N/AInorganic-Cadmium,
Heavy metal
Cadmium oxide1306-19-0#####NA 130N/AInorganic-Cadmium,
Heavy metal
Cadmium perborateNA 969NA 4613086N/AInorganic-Cadmium,
Heavy metal
Cadmium sebacate93949912903699N/AInorganic-Cadmium,
Heavy metal
Cadmium succinate141-00-41290492N/AInorganic-Cadmium,
Heavy metal
Cadmium sulfate10124-36-412905NA 123N/AInorganic-Cadmium,
Heavy metal
Cadmium yellow pigmentsNA 967NA 4482439N/AInorganic-Cadmium,
Heavy metal
Calcareous shaleNA 230NA 4493595N/AInorganic
Calcium arsenate7778-44-11350196Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide,
Molluscicide
Calcium arsenite53404-59-413602NA 129Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Calcium carbide75-20-7NA 4501571RepellentInorganic
Calcium carbonate471-34-1735021007pH Adjustment,Inorganic
Fungicide,
Microbiocide,
Herbicide
Calcium carbonate, treatedNA 968NA 4512440pH Adjustment,Inorganic
Fungicide,
Microbiocide,
Herbicide
Calcium chlorate10137-74-373302NA 682Defoliant,Inorganic
Herbicide,
Microbiocide
Calcium chloride10043-52-475605920Fungicide,Inorganic
Herbicide,
Insecticide,
Microbiocide,
Molluscicide,
Dessicant, Plant
Growth
Regulator
Calcium cyanide592-01-874001176RodenticideInorganic
Calcium hydroxide1305-62-07560199pH Adjustment,Inorganic
Fungicide,
Microbiocide,
Herbicide
Calcium hypochlorite7778-54-314701326Algaecide,Inorganic
Water
Treatment
Calcium nitrite13780-06-876202NA 701Rodenticide,Inorganic
Microbiocide
Calcium phosphate10103-46-5NA 195NA 195RodenticideInorganic
Calcium phosphate, tribasic7758-87-4764011607Rodenticide,Inorganic
Fungicide,
Herbicide,
Microbiocide
Calcium silicate10101-39-0726071908Insecticide,Inorganic
Adjuvant,
Fungicide,
Microbiocide
Calcium sulfate7778-18-956022442Insecticide,Inorganic
Herbicide
Calcium sulfate dihydrate10101-41-4203NA 163Insecticide,Inorganic
Herbicide
Calcium thiosulfate10124-41-180101930Insecticide,Inorganic
Fungicide,
Herbicide
Calcium-zinc LN 193NA 653NA 1203871N/AInorganic-Zinc
(complex)
Calomel10112-91-152201100FungicideInorganic-Mercury,
Heavy metal
Carbon7440-44-016001712WaterInorganic
Treatment,
Rodenticide
Carbon black pigment1333-86-4NA 4422445DyeInorganic
Carbon dioxide124-38-9166012207Fumigant,Inorganic
Insecticide,
Rodenticide
Carbon disulfide75-15-016401108Fumigant,Inorganic
Solvent,
Breakdown
product,
Nematicide
Chlorinated trisodium56802-99-4#####2214WaterInorganic
phosphate (prior TSP &Treatment
sodium hypochlorite)
Chlorine7782-50-520501131Microbiocide,Inorganic
Water
Treatment
Chlorine dioxide10049-04-4205032053Microbiocide,Inorganic
Water
Treatment
Chlorophyllin11006-34-1NA 191NA 190Fungicide,Inorganic-Copper,
MicrobiocideBotanical
Chromated zinc chlorideNA 1026878011187Insecticide,Inorganic-
Herbicide,Chromium(VI),
MicrobiocideInorganic-Zinc,
Heavy metal
Chromic acetate1066-30-421102NA 172WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Chromic acid7738-94-5211011188WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Chromic oxide1308-38-921103NA 173WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Chromium dioxide12018-01-8NA 4112470N/AInorganic
Cobaltous sulfate10124-43-3NA 1143110N/AInorganic
Copper7440-50-822501714FungicideInorganic-Copper
Copper (from triethanolamine82027-59-624403NA 198AlgaecideInorganic-Copper
complex)
Copper 2-ethylhexanoate22221-10-9412012235FungicideInorganic-Copper
Copper 3-phenylsalicylate125068223801NA 191N/AInorganic-Copper
Copper 8-quinolinoleate10380-28-624002159Fungicide,Inorganic-Copper
Microbiocide
Copper abietate10248-55-223301NA 184FungicideInorganic-Copper
Copper acetate83163244002147FungicideInorganic-Copper
Copper ammonium acetateNA 1544NA 225NA 225FungicideInorganic-Copper
Copper ammonium carbonate33113-08-5227031762FungicideInorganic-Copper
Copper ammonium complex16828-95-8227023550FungicideInorganic-Copper
Copper arsenate10103-61-422801NA 178Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Copper
Copper arsenite10290-12-722401NA 177Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Copper
Copper as elemental from50376-91-524404NA 199N/AInorganic-Copper
copper - etidronic acid complex
Copper beta cyclodextrinNA 1366NA 193NA 193FungicideInorganic-Copper
hydroxide
Copper bronze powder7440-50-8225011457AntifoulantInorganic-Copper
Copper carbonate, basic1184-64-12290160Fungicide,Inorganic-Copper
Algaecide,
Insecticide
Copper chloride (anhydrous)1344-67-823802NA 192N/AInorganic-Copper
Copper chloride (dihydrate)10125-13-023701NA 190N/AInorganic-Copper
Copper citrate10402-15-0440051406N/AInorganic-Copper
Copper citrate chelateNA 961NA 3873547N/AInorganic-Copper
Copper complex with ammonia67989-88-2#####NA 130FungicideInorganic-Copper
and ethylene diamine
tetraacetate
Copper cresylate12379-42-923001NA 181FungicideInorganic-Copper
Copper53404-24-341202NA 349N/AInorganic-Copper
dehydroabietylammonium 2-
ethylhexanoate
Copper dihydrazinium sulfate33271-65-750504753N/AInorganic-Copper
Copper ethanolamine complex14215-52-224409NA 201AlgaecideInorganic-Copper
Copper ethanolamineNA 1044NA 1463551AlgaecideInorganic-Copper
complexes, mixed
Copper ethylenediamine13426-91-0244073549HerbicideInorganic-Copper
complex
Copper gluconate chelate814-91-5233053548N/AInorganic-Copper
Copper hydrazinium sulfate53433-02-650501NA 418FungicideInorganic-Copper
Copper hydroxide20427-59-223401151Fungicide,Inorganic-Copper
Microbiocide,
Nematicide
Copper hydroxide - NA 1017NA 1051826N/AInorganic-Copper
triethanolamine complex
Copper isodecanoate84082-88-241221NA 354N/AInorganic-Copper
Copper isononanoate72915-82-341211NA 352N/AInorganic-Copper
Copper isooctanoate88859-94-341204NA 350N/AInorganic-Copper
Copper lactate16039-52-423302NA 185N/AInorganic-Copper
Copper linoleate7721-15-5233031110N/AInorganic-Copper
Copper metaborate39290-85-222802NA 179N/AInorganic-Copper
Copper monoethanolamineNA 960NA 3843552N/AInorganic-Copper
complex
Copper naphthenate1338-02-923102153WoodInorganic-Copper
Preservative,
Insecticide,
Fungicide, Dog
and Cat
Repellent
Copper naphthenate1338-02-96000NA 172WoodInorganic-Copper
Preservative,
Insecticide,
Fungicide, Dog
and Cat
Repellent
Copper naphthenate1338-02-96300NA 172WoodInorganic-Copper
Preservative,
Insecticide,
Fungicide, Dog
and Cat
Repellent
Copper nitroacetate22221-12-123201NA 183N/AInorganic-Copper
Copper octanoate20543-04-8233065225FungicideInorganic-Copper
Copper oleate10402-16-123304154FungicideInorganic-Copper
Copper oxide (ic)1317-38-0424012231Fungicide,Inorganic-Copper
Insecticide
Copper oxide (ous)1317-39-125601175Fungicide,Inorganic-Copper
Insecticide
Copper oxychloride1332-40-78001156FungicideInorganic-Copper
Copper oxychloride1332-65-623501NA 186FungicideInorganic-Copper
(Cu2Cl(OH)3)
Copper oxychloride sulfate8012-69-923503158FungicideInorganic-Copper
Copper oxysulfate12158-97-323504NA 188N/AInorganic-Copper
Copper oxysulfate82010-79-523504NA 189N/AInorganic-Copper
Copper pentachlorophenate15773-35-063011NA 512WoodChlorinated Phenol,
Preservative,Inorganic-Copper
Microbiocide,
Algaecide,
Fungicide
Copper phosphate10103-48-722902NA 180N/AInorganic-Copper
Copper phthalocyanine147-14-8NA 3812479DyeInorganic-Copper
Copper pyrophosphate10102-90-669701NA 663N/AInorganic-Copper
Copper salts of fatty and rosin9007-39-023104155FungicideInorganic-Copper
acids
Copper salts of the acids of tall61789-22-823103NA 182N/AInorganic-Copper
oil
Copper silicate1344-72-524301NA 197N/AInorganic-Copper
Copper sodium sulfate-NA 1023NA 121755N/AInorganic-Copper
phosphate complex
Copper sulfate (anhydrous)7758-98-7244081778Fungicide,Inorganic-Copper
Algaecide,
Molluscicide
Copper sulfate (basic)1344-73-68101162Fungicide,Inorganic-Copper
Algaecide,
Molluscicide
Copper sulfate (pentahydrate)7758-99-824401161Algaecide,Inorganic-Copper
Fungicide,
Insecticide,
Water
Treatment,
Molluscicide,
Nematicide
Copper sulfate ethyleneNA 1036NA 1322480N/AInorganic-Copper
diamine
Copper sulfate, monohydrate10257-54-2244021789Fungicide,Inorganic-Copper
Algaecide,
Molluscicide
Copper sulfate, tri-basicNA 1384NA 195NA 194Herbicide,Inorganic-Copper
Algaecide,
Fungicide,
Water
Treatment
Copper triethanolamine68027-59-6NA 1251615AlgaecideInorganic-Copper
complex
Copper-zinc chromate complex1344-74-721003163Fungicide,Inorganic-
WoodChromium(VI),
PreservativeInorganic-Zinc,
Heavy metal,
Inorganic-Copper
Copper-zinc sulfate complex55072-57-68102164FungicideInorganic-Zinc,
Inorganic-Copper
Copper-zinc sulfate complex,NA 959NA 3821751FungicideInorganic-Zinc,
monohydrateInorganic-Copper
Crag turf fungicide 53112001-20-621006NA 171FungicideInorganic-Cadmium,
(Cd—Cu—Ca—Zn-Chromate)Inorganic-
Chromium(VI),
Inorganic-Zinc,
Heavy metal
Cryolite15096-52-375101173InsecticideInorganic
CuprammoniumNA 1382NA 195NA 194FungicideInorganic-Copper
Cupric acetoarsenite12002-03-8226012485WoodInorganic-arsenic,
PreservativeHeavy metal,
Inorganic-Copper
Cupric ferric subsulfate12168-20-642402NA 365MolluscicideInorganic-Copper
complex
Cupric fluosilicate12062-24-775309NA 692InsecticideInorganic-Copper
Cupric gluconate527-09-3244053117FungicideInorganic-Copper
Cupric nitrate3251-23-8761023118N/AInorganic-Copper
Cuprous and cupric oxide,82010-82-042403NA 366N/AInorganic-Copper
mixed
Cuprous chloride (Cu2Cl2)7758-89-6#####5597FungicideInorganic-Copper
Cuprous iodide7681-65-4#####NA 902N/AInorganic-Copper
Cuprous sulfide22205-45-4#####NA 124N/AInorganic-Copper
Cuprous thiocyanate1111-67-7256022108MicrobiocideInorganic-Copper
Device (swimming poolNA 1504NA 222NA 222AlgaecideInorganic-Copper
algaecide, copper generating)
no guarantee required
Device (swimming poolNA 1505NA 222NA 222AlgaecideInorganic
algaecide, peroxide) no
guarantee required
Device (swimming poolNA 1506NA 222NA 222AlgaecideInorganic
algaecide, salt in pool) no
guarantee required
Di-potassium salts of13492-26-776416NA 704Fungicide,Inorganic
phosphorous acidMicrobiocide
Diammonium phosphate7783-28-0NA 819654Insecticide,Inorganic
Fungicide,
Herbicide,
Microbiocide,
pH Adjustment
Diatomaceous earth7631-86-972605195Insecticide,Inorganic
Molluscicide
Diatomaceous earth, otherNA 1155NA 17390195Insecticide,Inorganic
relatedMolluscicide
Dihydrogen54453-03-124406NA 200N/AInorganic-Copper
{ethylenediaminetetraacetato(4-
)}cuprate(2-)
Disodium EDTA-copper14025-15-1NA 2963173N/AInorganic-Copper
Disodium mono ethanolamine53404-45-8764101608pH Adjustment,Inorganic
phosphateFungicide,
Herbicide,
Microbiocide
Disodium octaborate12008-41-2111075053InsecticideInorganic
anhydrous
Disodium octaborate12280-03-4111031800Insecticide,Inorganic
tetrahydrateHerbicide
Disodium phosphate7558-79-4764032534pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
EDTA diammonium copper7379-26-2391171613AlgaecideInorganic-Copper
salt
EDTA, copper complex12276-01-6391051135AlgaecideInorganic-Copper
EDTA, disodium zinc salt14025-21-9NA 2743189N/AInorganic-Zinc
Fatty acid* - silver complex24927-67-172505NA 675Microbiocide,Inorganic-Silver,
*(100% C8)Fungicide,Heavy metal
Herbicide
Feldspar68476-25-5NA 1183656N/AInorganic
Ferric chloride7705-08-0349013205HerbicideInorganic
Ferric oxide1332-37-2NA 1043206N/AInorganic
Ferric sulfate (anhydrous)10028-22-5349021811HerbicideInorganic
Ferrous ammonium sulfate10045-89-3505061307HerbicideInorganic
Ferrous ammonium sulfate7783-85-950509NA 421HerbicideInorganic
hexahydrate
Ferrous sulfate7720-78-7NA 120289Herbicide,Inorganic
Molluscicide
Ferrous sulfate (monohydrate)17375-41-6505071812Herbicide,Inorganic
Defoliant
Ferrous sulfate heptahydrate7782-63-0505021687HerbicideInorganic
GraniteNA 105NA 2093663N/AInorganic
Graphite7782-42-5NA 2103217N/AInorganic
Hydrated lime1302-62-0NA 1943669pH Adjustment,Inorganic
Fungicide,
Microbiocide,
Herbicide
Hydriodic acid10034-85-246912NA 408N/AInorganic
Hydrocyanic acid74-90-845801NA 388FumigantInorganic
Hydrofluoric acid7664-39-345601NA 387N/AInorganic
Hydrogen chloride7647-01-045901329FumigantInorganic
Fungicide,
Nematicide, pH
Adjustment,
Herbicide
Hydrogen peroxide7722-84-15951794Microbiocide,Inorganic
Fungicide,
Herbicide,
Rodenticide
Hydrogen sulfide2147416NA 227NA 227BreakdownInorganic
product
Hydrophosphorous acidNA 95NA 1892600N/AInorganic
Hydroxymercury cresol12379-66-746001NA 390MicrobiocideInorganic-Mercury,
Heavy metal, Phenols
Hypochlorous acid7790-92-3#####NA 110WaterInorganic
Treatment,
Microbiocide,
pH Adjustment
Hypoiodous acid14332-21-9#####NA 153N/AInorganic
Inorganic phosphateNA 940NA 1693671pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Iodic acid7782-68-546902NA 405N/AInorganic
Iodine7553-56-246905718Microbiocide,Inorganic
Fungicide,
Herbicide
Iron7439-89-6NA 121655N/AInorganic
Iron oxide (Fe2O3)1309-37-1#####NA 870HerbicideInorganic
Iron oxide pigmentNA 942NA 1752618DyeInorganic
Iron phosphate10045-86-0349035014MolluscicideInorganic
Kaolin1332-58-7#####2629Insecticide,Inorganic
Adjuvant,
Fungicide,
Microbiocide
Lauric acid, barium cadmium15337-60-7NA 1183676AdjuvantInorganic-Cadmium,
saltHeavy metal
Lead7439-92-1NA 1342638N/AInorganic-Lead,
Heavy metal
Lead acetate301-04-248001NA 415N/AInorganic-Lead,
Heavy metal
Lead arsenate7784-40-913503353Herbicide,Inorganic-arsenic,
Insecticide,Inorganic-lead,
RodenticideHeavy metal
Lead arsenate, basic1327-31-713502354Herbicide,Inorganic-arsenic,
Insecticide,Inorganic-lead,
RodenticideHeavy metal
Lead metasilicateNA 938NA 1381106N/AInorganic-Lead,
Heavy metal
Lead monoxide10190-55-3NA 1231271N/AInorganic-Lead,
Heavy metal
Lead naphthenate61790-14-5480043296N/AInorganic-Lead,
Heavy metal
Lignin sulfonic acid, copperNA 933NA 1261925N/AInorganic-Copper
salt
Lignin sulfonic acid, zinc saltNA 1014NA 1021768N/AInorganic-Zinc
Lignin sulfonic acid, zinc,NA 1030NA 1261771N/AInorganic-Zinc
manganese & iron salts
Lime1305-78-875604977pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Lime phosphateNA 1432NA 200NA 199Plant GrowthInorganic
Regulator
Lime-sulfur1344-81-676702358Insecticide,Inorganic
Fungicide
Litharge1317-36-848002NA 416N/AInorganic-Lead,
Heavy metal
Lithium carbonate554-13-2NA 1193924pH Adjustment,Inorganic
Fungicide,
Microbiocide,
Herbicide
Lithium chloride7447-41-8#####5318N/AInorganic
Lithium hydroxide1310-65-2NA 1433267pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Lithium hypochlorite13840-33-014702922Microbiocide,Inorganic
Water
Treatment
Lithium perchlorate2150251NA 1153268N/AInorganic
Magnesium aluminum1327-43-175310NA 693InsecticideInorganic
fluosilicate
Magnesium arsenate10103-50-113504NA 126Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Magnesium carbonate546-93-0735032654pH Adjustment,Inorganic
Fungicide,
Microbiocide,
Herbicide
Magnesium chlorate10326-21-3#####NA 155Defoliant,Inorganic
Herbicide,
Microbiocide
Magnesium chloride7786-30-313902365Molluscicide,Inorganic
Herbicide,
Insecticide,
Microbiocide
Magnesium chloride,7791-18-6NA 1102655Molluscicide,Inorganic
hexahydrateHerbicide,
Insecticide,
Microbiocide
Magnesium fluosilicate16949-65-875304NA 689InsecticideInorganic
Magnesium limeNA 931NA 1113679N/AInorganic
Magnesium nitrate10377-60-3NA 1153269Rodenticide,Inorganic
Microbiocide
Magnesium oxide1309-48-492352656pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Magnesium phosphide12057-74-8665042085Fumigant,Inorganic
Rodenticide
Magnesium silicate1343-88-072601NA 680Insecticide,Inorganic
Adjuvant,
Fungicide,
Microbiocide
Magnesium silicate, hydrous14807-96-6NA 1132658AdjuvantInorganic
Magnesium sulfate7487-88-9505031339Molluscicide,Inorganic
Adjuvant
Malachite (copper equivalent1319-53-5#####NA 155N/AInorganic-Copper
57%)
Mancozeb223310014504211FungicideDithiocarbamate,
Inorganic-Zinc
Maneb and nickel sulfate8005-46-7#####NA 158FungicideDithiocarbamate,
hexahydrate (014505 + 050505)Inorganic-Nickel
Manganese (II) oxide1344-43-0NA 1043274N/AInorganic
Manganese arsenate7784-38-513506NA 127Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Manganese carbamateNA 55NA 1033273N/AInorganic
Manganese sulfate7785-87-7NA 105658N/AInorganic
Manganous oxide1344-43-0NA 1433275N/AInorganic
Mercuric acetate1600-27-752104NA 441N/AInorganic-Mercury,
Heavy metal
Mercuric chloride7487-94-752001372FungicideInorganic-Mercury,
Heavy metal
Mercuric dimethyl15415-64-234808709MicrobiocideInorganic-Mercury,
dithiocarbamateHeavy metal,
Dithiocarbamate
Mercuric iodide7774-29-052003NA 438N/AInorganic-Mercury,
Heavy metal
Mercuric oleate1191-80-6521053276N/AInorganic-Mercury,
Heavy metal
Mercuric oxide21908-53-252102955FungicideInorganic-Mercury,
Heavy metal
Mercury7439-97-652301NA 26N/AInorganic-Mercury,
Heavy metal
Mercury naphthenate1336-96-552101NA 439WoodInorganic-Mercury,
Preservative,Heavy metal
Insecticide,
Fungicide
Mercury pentanedione14024-55-652103NA 440N/AInorganic-Mercury,
Heavy metal
Mercury phenate588-66-952106NA 442N/AInorganic-Mercury,
Heavy metal
Metallic silver7440-22-4725012125Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Metiram9006-42-214601493FungicideDithiocarbamate,
Inorganic-Zinc
Mica12003-33-2NA 1183690N/AInorganic
Mixed copper chelates orNA 1437NA 213NA 212FungicideInorganic-Copper
complex blend of copper salts
Molybdenum7439-98-7NA 1523903N/AInorganic
Molybdic acid, disodium salt7631-95-0NA 1352690N/AInorganic
Mono-potassium salts of13977-65-676416NA 705Fungicide,Inorganic
phosphorous acidMicrobiocide
Monosodium phosphate7558-80-7764091772pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
N-(2-hydroxyethyl) ethyleneNA 1025NA 1221130N/AInorganic-Copper
diamine triacetic acid, copper
salt
Neodecanoic acid, copper salt50315-14-597503NA 854N/AInorganic-Copper
Nickel7440-02-0NA 121762N/AInorganic-Nickel
Nickel diethyl hexyl acidNA 928NA 533696N/AInorganic-Nickel
phosphate complex
Nickel sulfate (anhydrous)7786-81-450508NA 420FungicideInorganic-Nickel
Nickel sulfate hexahydrate10101-97-050505NA 419FungicideInorganic-Nickel
Nitric acid7697-37-245951NA 389N/AInorganic
Nitric acid technical7697-37-2NA 472703N/AInorganic
Nitrogen trichloride10025-85-1NA 502705N/AInorganic
Nitrogen, liquified7727-37-9#####2267InsecticideInorganic
Nitrous oxide10024-97-2NA 1153302N/AInorganic
Noury dry cobalt 12%NA 21NA 332712N/AInorganic
Nuxtra manganese 12%NA 746NA 1352719N/AInorganic
catalyst
o-Phenylphenol, alkyl* amine-82010-74-064107NA 533MicrobiocidePhenols, Inorganic-
zinc salt of *(100% C18)Zinc
Oxalic acid144-62-79601899MicrobiocideInorganic
Ozone10028-15-6NA 228NA 228WaterInorganic
Treatment,
Microbiocide
p-tert-53433-01-552002NA 437MicrobiocideInorganic-Mercury,
OctylphenoxyethoxyethylHeavy metal
dimethyl benzyl ammonium
mercuric chloride
Paris green12002-03-822601460WoodInorganic-Arsenic,
PreservativeInorganic-Copper,
Heavy metal
Penta potassium triphosphate13845-36-8764123319N/AInorganic
Pentachlorophenol, zinc salt2917-32-063008NA 510WoodChlorinated Phenol,
Preservative,Inorganic-Zinc
Microbiocide,
Algaecide,
Fungicide
Perboric acid, sodium saltNA 1160NA 1745452InsecticideInorganic
Perboric acid, sodium salt,10332-33-9111055052InsecticideInorganic
monohydrate
Perchloric acid, calcium salt13477-36-6NA 6703321N/AInorganic
PerliteNA 756NA 1362767N/AInorganic
Peroxyacetic acid79-21-0632012291Microbiocide,Inorganic
Fungicide,
Herbicide,
Rodenticide
Peroxydisulfuric acid13445-49-363601NA 524N/AInorganic
Phosphine7803-51-2665003541Fumigant,Inorganic
Insecticide
Phosphoric acid7664-38-276001871Fungicide, pHInorganic
Adjustment,
Herbicide,
Microbiocide
Phosphoric acid, disodium salt,10028-24-776415NA 703pH Adjustment,Inorganic
dihydrateFungicide,
Herbicide,
Microbiocide
Phosphoric acid,7778-77-0764132777pH Adjustment,Inorganic
monopotassium saltFungicide,
Herbicide,
Microbiocide
Phosphoric acid, trisodium salt56802-99-4#####3851WaterInorganic
(chlorinated)Treatment
Phosphorous acid13598-36-276002NA 699Fungicide,Inorganic
Microbiocide
Phosphorus7723-14-066502513N/AInorganic
Phosphorus pentasulfide1314-56-3NA 6402778N/AInorganic
Polyoxin D zinc salt146659-78-1#####NA 129FungicideInorganic-Zinc
Potassium aluminum silicateNA 996NA 7743344AdjuvantInorganic
Potassium aluminum sulfate7784-24-9NA 7753345Insecticide,Inorganic
Herbicide
Potassium arsenite10124-50-213605NA 131Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Potassium arsenite13464-35-213605NA 132Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Potassium azide20762-60-1#####NA 898N/AInorganic
Potassium bicarbonate298-14-6735085037FungicideInorganic
Potassium bifluoride7789-29-975203NA 687N/AInorganic
Potassium bisulfate7646-93-756051860pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Potassium bromide2138164139031090MicrobiocideInorganic
Potassium carbonate584-08-7735041620pH Adjustment,Inorganic
Fungicide,
Microbiocide,
Herbicide
Potassium chlorate696616733033347Defoliant,Inorganic
Herbicide,
Microbiocide
Potassium chloride7447-40-713904NA 137N/AInorganic
Potassium chromate7789-00-668301700WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Potassium cyanate590-28-368002NA 600N/AInorganic
Potassium cyanide151-50-8#####497RodenticideInorganic
Potassium dichromate7778-50-9683022167WoodInorganic-
PreservativeChromium(VI)
Potassium hexafluoroarsenate17029-22-0#####NA 160N/AInorganic-arsenic,
Heavy metal
Potassium hydroxide1310-58-3756021306pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Potassium hypochlorite7778-66-7#####NA 110MicrobiocideInorganic
Potassium iodate213825675703NA 696N/AInorganic
Potassium iodate (KH(IO3)2)13455-24-875704NA 697N/AInorganic
Potassium iodide7681-11-0757011003MicrobiocideInorganic
Potassium mercuric iodide7783-33-752107NA 443N/AInorganic-Mercury,
Heavy metal
Potassium monopersulfate10361-76-9#####NA 104N/AInorganic
Potassium nitrate7757-79-176103726Rodenticide,Inorganic
Microbiocide
Potassium nitrite7758-09-0762033356Rodenticide,Inorganic
Microbiocide
Potassium permanganate7722-64-768501498Fungicide,Inorganic
Algaecide,
Molluscicide,
Microbiocide
Potassium peroxydisulfate7727-21-1636021028Microbiocide,Inorganic
Fungicide,
Herbicide,
Rodenticide
Potassium peroxymonosulfate10058-23-8636041859Microbiocide,Inorganic
Fungicide,
Herbicide,
Rodenticide
Potassium peroxymonosulfate37222-66-563607NA 527Microbiocide,Inorganic
sulfate,Fungicide,
(2KHSO5.KHSO4.K2SO4)Herbicide,
Rodenticide
Potassium peroxymonosulfate70693-62-863607NA 528Microbiocide,Inorganic
sulfate,Fungicide,
(2KHSO5.KHSO4.K2SO4)Herbicide,
Rodenticide
Potassium phosphate7778-53-2764073358pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Potassium phosphate, dibasic2138438#####3359pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Potassium phosphiteNA 1565NA 2295766FungicideInorganic
Potassium phosphonateNA 1563NA 227NA 227FungicideInorganic
(phosphorous acid equivalent)
Potassium polysulfide37199-66-976703NA 708Insecticide,Inorganic
Fungicide
Potassium pyrophosphate7320-34-5764081175pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Potassium silicate1312-76-1726062826Insecticide,Inorganic
Adjuvant,
Fungicide,
Microbiocide
Potassium sulfate7778-80-556033362Insecticide,Inorganic
Herbicide
Potassium sulfite10117-38-1NA 7853364FungicideInorganic
Potassium tetraborate1332-77-0NA 1443365InsecticideInorganic
Potassium tetrathionate13932-13-375903NA 698Insecticide,Inorganic
Herbicide
Potassium thiocyanate333-20-068201NA 605InsecticideInorganic
Potassium thiosulfate10233-00-880102NA 773Insecticide,Inorganic
Fungicide,
Herbicide
Potassium triiodide12298-68-9469175066MicrobiocideInorganic
Propineb12071-83-9#####NA 155Fungicide,Dithiocarbamate,
MicrobiocideInorganic-Zinc
Pumice1332-09-8NA 1503777N/AInorganic
Quartz sandNA 1363NA 193NA 192InsectInorganic
Repellent
Rock powderNA 1375NA 194NA 194N/AInorganic
Selenium and compounds7782-49-272001NA 31N/AInorganic
Selenium disulfide7488-56-472003NA 673N/AInorganic
ShaleNA 459NA 8213794N/AInorganic
Silica aerogel63231-67-472602529Insecticide,Inorganic
Adjuvant,
Fungicide,
Microbiocide
Silica gel63231-67-4726023557Insecticide,Inorganic
Adjuvant,
Fungicide,
Microbiocide
Silica hydrateNA 461NA 8242853N/AInorganic
Silica, crystalline-fused60676-86-0NA 8232851N/AInorganic
Silica, crystalline-quartz14808-60-7NA 1382852N/AInorganic
Silicic acid1343-98-2NA 8253556N/AInorganic
Silicon dioxide fresh waterNA 1524NA 223NA 223InsecticideInorganic
fossils
Silver acetate563-63-372507NA 676Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver carbonate534-16-772509NA 678Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver chloride7783-90-6725062324Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver copper zeolite130328-19-7#####NA 110MicrobiocideInorganic-Silver,
Heavy metal,
Inorganic-Copper
Silver fluoride7775-41-972502NA 674Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver iodide, colloidal7783-96-2NA 1241556Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver nitrate7761-88-8725032856Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide,
Plant Growth
Regulator
Silver orthophosphate7784-09-072510NA 679Microbiocide,Inorganic-Silver,
(Ag3PO4)Fungicide,Heavy metal
Herbicide
Silver oxide (Ag4O4)1301-96-8#####NA 111Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver oxide (Ag4O4)155645-89-9#####NA 111Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver sodium hydrogenNA 116672560NA 164MicrobiocideInorganic-Silver,
zirconium phosphateHeavy metal
(Ag0.18Na0.57H0.25Zr2(PO4)3)
Silver thiocyanate1701-93-568203NA 606Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver thiuronium acrylate copolymer53404-00-572701NA 681Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver zeolite130328-18-6#####NA 125MicrobiocideInorganic-Silver,
Heavy metal
Silver zinc zeolite130328-20-0#####NA 111MicrobiocideInorganic-Silver,
Inorganic-Zinc,
Heavy metal
Silver, ionic14701-21-4NA 1695150Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
SoapstoneNA 465NA 8293797N/AInorganic
Sodium7440-23-5NA 8302858N/AInorganic
Sodium acid phosphate7558-80-7764091413pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Sodium acid pyrophosphate7758-16-9NA 8313381pH AdjustmentInorganic
Sodium aluminate1302-42-7NA 1453382N/AInorganic
Sodium aluminum fluosilicate53404-77-675308NA 691InsecticideInorganic
Sodium aluminum phosphate7785-88-8NA 8323383N/AInorganic
Sodium arsenate13464-38-513505283Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Sodium arsenite7784-46-513603534Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide,
Fungicide
Sodium azide26628-22-8#####NA 897N/AInorganic
Sodium bicarbonate144-55-8735051134Fungicide, pHInorganic
Adjustment
Sodium bichromate dihydrate7789-12-0683063980WoodInorganic-
PreservativeChromium(VI),
Inorganic
Sodium bifluoride1333-83-1752013385N/AInorganic
Sodium binoxalate1186-49-89602NA 110MicrobiocideInorganic
Sodium bisulfate7681-38-173201905pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Sodium bisulfite7631-90-578201547pH Adjustment,Inorganic
Fungicide
Sodium borohydride16940-66-2NA 8343387N/AInorganic
Sodium bromate7789-38-013908NA 138N/AInorganic
Sodium bromide7647-15-6139071103Molluscicide,Inorganic
Herbicide,
Insecticide,
Microbiocide
Sodium carbonate497-19-873506854pH Adjustment,Inorganic
Fungicide,
Microbiocide,
Herbicide
Sodium chlorate214459173301536Defoliant,Inorganic
Herbicide,
Microbiocide
Sodium chloride7647-14-513905721Molluscicide,Inorganic
Herbicide,
Insecticide,
Microbiocide
Sodium chlorite7758-19-2205022148Microbiocide,Inorganic
Water
Treatment
Sodium chromate2144646683031241WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Sodium cyanide143-33-974002688RodenticideInorganic
Sodium dichromate10588-01-9683043395WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Sodium dihydrogen phosphate7558-80-7764091022pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Sodium fluoride7681-49-475202537WoodInorganic
Preservative,
Insecticide
Sodium fluosilicate16893-85-975306538InsecticideInorganic
Sodium hexametaphosphate10124-56-8764021623pH AdjustmentInorganic
Sodium hydrosulfite7775-14-6782023408pH AdjustmentInorganic
Sodium hydroxide1310-73-275603362pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Sodium hypobromiteNA 1442NA 214NA 213MicrobiocideInorganic
Sodium hypochlorite7681-52-914703539Microbiocide,Inorganic
Water
Treatment,
Nematicide
Sodium hypophosphate13721-43-2NA 8483409N/AInorganic
Sodium hypophosphite7681-53-0NA 8493410N/AInorganic
Sodium iodide7681-82-575702NA 695N/AInorganic
Sodium metabisulfite7681-57-4NA 191NA 190FungicideInorganic
Sodium metaborate7775-19-111104689InsecticideInorganic
Sodium metaborate octahydrateNA 1045NA 1544012InsecticideInorganic
Sodium metaborateNA 1046NA 1544013InsecticideInorganic
tetrahydrate
Sodium metasilicate6834-92-072604940Insecticide,Inorganic
Adjuvant,
Fungicide,
Microbiocide
Sodium metasilicate,6834-92-0726041840Insecticide,Inorganic
anhydrousAdjuvant,
Fungicide,
Microbiocide
Sodium molybdate7631-95-0NA 8551761N/AInorganic
Sodium nitrate7631-99-476104696Rodenticide,Inorganic
Microbiocide
Sodium nitrite7632-00-0762042862Rodenticide,Inorganic
Microbiocide
Sodium oxalate62-76-09604NA 111MicrobiocideInorganic
Sodium pentaborate11139-65-4NA 8621347Insecticide,Inorganic
Plant Growth
Regulator
Sodium perborate2092204#####3429InsecticideInorganic
Sodium perborate (NaBO3)10486-00-711108NA 115InsecticideInorganic
tetrahydrate
Sodium permanganate10101-50-5NA 1453430N/AInorganic
Sodium peroxide (Na2(O2))1313-60-663606NA 526Microbiocide,Inorganic
Fungicide,
Herbicide,
Rodenticide
Sodium persulfate7775-27-1636032336N/AInorganic
Sodium phosphate7558-79-4764031790pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Sodium phosphate, monobasic7558-80-7764093433pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Sodium polysulfide1344-08-76902541Insecticide,Inorganic
Fungicide
Sodium pyroarsenate13464-42-1134012864WoodInorganic-arsenic,
Preservative,Heavy metal
Fungicide
Sodium selenate13410-01-072002NA 672N/AInorganic
Sodium sesquicarbonate533-96-0735071292pH Adjustment,Inorganic
Fungicide,
Microbiocide,
Herbicide
Sodium silicate1344-09-8726032865Insecticide,Inorganic
Adjuvant,
Fungicide,
Microbiocide
Sodium silicoaluminateNA 1005NA 8682866AdjuvantInorganic
Sodium silver thiosulfateNA 1398NA 197NA 196HerbicideInorganic-Silver,
Heavy metal
Sodium sulfate7757-82-656041532Insecticide,Inorganic
Herbicide
Sodium sulfide1313-82-2NA 214NA 213N/AInorganic
Sodium sulfite7757-83-7782031635FungicideInorganic
Sodium tetraborate (anhydrous)1330-43-4111125054Insecticide,Inorganic
Herbicide,
Molluscicide
Sodium tetraborate11130-12-4NA 8711808InsecticideInorganic
(pentahydrate)
Sodium tetrathiocarbonate7345-69-9#####2273Fumigant,Inorganic
Fungicide,
Nematicide
Sodium thioarsenate17367-56-513507NA 128N/AInorganic-arsenic,
(Na3AsO3S)Heavy metal
Sodium thiocyanate540-72-768202848HerbicideInorganic
Sodium thiosulfate7772-98-780104332Insecticide,Inorganic
Fungicide,
Herbicide
Sodium tripolyphosphate7758-29-4764041024pH AdjustmentInorganic
Sulfur7704-34-977501560Fungicide,Inorganic
Insecticide
Sulfur chloride10025-67-9NA 1163461N/AInorganic
Sulfur dichloride10545-99-0NA 9153462N/AInorganic
Sulfur dioxide202442277601561DessicantInorganic
Sulfuric acid7664-93-978001442Herbicide,Inorganic
Dessicant,
Fungicide,
Microbiocide,
pH Adjustment
Sulfuryl chloride7791-25-578002NA 721N/AInorganic
Sulfuryl fluoride2699-79-878003618FumigantInorganic
Talc14807-96-6NA 9232911N/AInorganic
Tetracopper calcium1336-15-823502NA 187FungicideInorganic-Copper
oxychloride
Tetrapotassium pyrophosphate7320-34-5764081918pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Tetrasodium pyrophosphate7722-88-5764053474pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Thallium(I) sulfate7446-18-680001NA 35RodenticideInorganic, Heavy
metal
Titanium dioxide13463-67-7NA 9542942N/AInorganic
Titanium sulfate13825-74-6NA 1113476N/AInorganic
Tricopper dichloride7076-63-3#####NA 152MicrobiocideDithiocarbamate,
dimethyldithiocarbamateInorganic-Copper
Tripotassium phosphate7778-53-2764071055pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Trisodium phosphate7601-54-9764061579pH Adjustment,Inorganic
Fungicide,
Herbicide,
Microbiocide
Urea57-13-685702662Microbiocide,Inorganic
Fungicide
Urea dihydrogen sulfate21351-39-3#####2270Plant GrowthInorganic
Regulator,
Herbicide
VermiculiteNA 778NA 1402983N/AInorganic
WaterNA 557NA 1012987SolventInorganic
Zinc7440-66-6#####2310HerbicideInorganic-Zinc
Zinc 2,4,5-trichlorophenate136-24-364221NA 546N/AChlorinated Phenol,
Inorganic-Zinc
Zinc 2-ethyl hexoate136-53-8412033509N/AInorganic-Zinc
Zinc 2-pyridinethiol-1-oxide13463-41-7880022128MicrobiocideInorganic-Zinc
Zinc 8-quinolinolate13978-85-324005NA 196Fungicide,Inorganic-zinc
Microbiocide
Zinc abietate6798-76-1NA 1123506N/AInorganic-Zinc
Zinc arsenate13464-44-313301NA 125Herbicide,Inorganic-Arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Zinc
Zinc arsenite28837-97-013604NA 130Herbicide,Inorganic-Arsenic,
Insecticide,Inorganic-Zinc,
RodenticideHeavy metal
Zinc bacitracin1405-89-66309NA 87MicrobiocideInorganic-Zinc
Zinc carbonate3486-35-9NA 1023507N/AInorganic-Zinc
Zinc chloride7646-85-787801624MicrobiocideInorganic-Zinc
Zinc dehydroabietylammonium53404-92-54211NA 75Fungicide,Inorganic-Zinc
2-ethylhexanoateMicrobiocide
Zinc dodecyl benzene sulfonate12068-16-5NA 1123508Microbiocide,Soap, Inorganic-Zinc
Adjuvant,
Fungicide,
Insecticide
Zinc fluosilicate16871-71-9753071019InsecticideInorganic-Zinc
Zinc formate557-41-587802NA 838N/AInorganic-Zinc
Zinc hydroxide20427-58-1885013510N/AInorganic-Zinc
Zinc isodecanoate30304-30-441222NA 355N/AInorganic-Zinc
Zinc isononanoate5398-80-641212NA 353N/AInorganic-Zinc
Zinc isooctanoate84082-93-941205NA 351N/AInorganic-Zinc
Zinc mercury chromate22323-45-121004NA 170FungicideInorganic-Mercury,
Inorganic-
chromium(VI),
Inorganic-Zinc,
Heavy metal
Zinc naphthenate12001-85-3883011111WoodInorganic-Zinc
Preservative,
Insecticide,
Fungicide, Dog
and Cat
Repellent
Zinc neodecanoate27253-29-897502NA 853N/AInorganic-Zinc
Zinc oxide1314-13-288502666Fungicide,Inorganic-Zinc
Adjuvant
Zinc petroleum (C20-C30)68989-17-388503NA 841N/AInorganic-Zinc
sulfonate
Zinc phenol sulfonate127-82-289002NA 842N/AInorganic-Zinc
Zinc phosphide1314-84-788601626RodenticideInorganic-Zinc
Zinc resinate9010-69-977001NA 712N/AInorganic-Zinc
Zinc silicateNA 13188103NA 176MicrobiocideInorganic-Zinc
Zinc stearate557-05-1770023511N/AInorganic-Zinc
Zinc sulfate7733-02-089001667Microbiocide,Inorganic-Zinc
Herbicide
Zinc sulfate, anhydrous7733-02-0890011852Microbiocide,Inorganic-Zinc
Herbicide
Zinc sulfate, basic68813-94-589101NA 843N/AInorganic-Zinc
Zinc sulfate, monohydrate7446-19-7#####2995HerbicideInorganic-Zinc
Zinc trichlorophenate30143-22-764213NA 543MicrobiocideChlorinated Phenol,
Inorganic-Zinc
Zineb12122-67-714506627FungicideDithiocarbamate,
Inorganic-Zinc
Zineb-ethylene thiuramNA 1465NA 217NA 216FungicideDithiocarbamate,
disulfide adductInorganic-Zinc
Ziram137-30-434805629Fungicide,Dithiocarbamate,
Microbiocide,Inorganic-Zinc
Dog and Cat
Repellent
Ziram, cyclohexylamine16509-79-8348061328Dog and CatDithiocarbamate,
complexRepellent,Inorganic-Zinc
Fungicide
(3-Ethoxypropyl)mercury6012-84-6#####NA 147FungicideOrganomercury,
bromideHeavy metal
(3-Hydroxy-2-69653-69-6#####NA 153N/AOrganomercury,
methoxypropyl)mercuricHeavy metal
acetate
10,10′-Oxybisphenoxyarsine58-36-6126011402Fungicide,Organoarsenic,
MicrobiocideHeavy metal
2-(acetoxymercuri)ethanol4665-55-841501NA 356N/AOrganomercury,
Heavy metal
3-(Hydroxymercuri)-4-nitro-o-53404-55-052604NA 447MicrobiocideOrganomercury,
phenol, sodium saltHeavy metal
Ammonium arsenate7784-44-3136012380Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Ammonium dichromate214970168305NA 607WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Anilinocadmium dilactate19651-91-364601NA 548N/AInorganic-Cadmium,
Heavy metal
Arsenic7440-38-2NA 121710Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic acid7778-39-4680140Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic disulfide56320-22-06901NA 98Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic pentoxide1303-28-26802631Fungicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide,
Herbicide
Arsenic sulfide12612-21-46901NA 99Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic trioxide1327-53-3700142Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic trisulfide1303-33-96901NA 97Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenosobenzene637-03-67101NA 100N/AOrganoarsenic,
Heavy metal
Arsonic acid, (4-aminophenyl)-98-50-0#####NA 109N/AOrganoarsenic,
Heavy metal
Arsonic acid, ammonium salt58829-95-1#####NA 105Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Wood
Preservative
Azocyclotin41083-11-8#####2408InsecticideOrganotin, Heavy
metal
Basic bismuth gallate99-26-398601NA 860N/AHeavy metal
Basic copper arsenate16102-92-4#####NA 132Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Copper
Basic lead silicate53466-66-348003NA 417N/AInorganic-Lead,
Heavy metal
Bis (tributyltin) adipate7437-35-6831171990Antifoulant,Organotin, Heavy
Microbiocidemetal
Bis (tributyltin) sulfide4808-30-4831131886Antifoulant,Organotin, Heavy
Microbiocidemetal
Bis (tributyltin) sulfoneNA 970NA 4761665Antifoulant,Organotin, Heavy
Microbiocidemetal
Bis(tributyltin)12379-54-383101NA 824Antifoulant,Organotin, Heavy
dodecenylsuccinateMicrobiocidemetal
Bis(tributyltin) salicylate22330-14-9831025074Antifoulant,Organotin, Heavy
Microbiocidemetal
Bis(tributyltin) succinate4644-96-68310374Antifoulant,Organotin, Heavy
Microbiocidemetal
Bis(tributyltin) sulfosalicylate4419-22-183104NA 825Antifoulant,Organotin, Heavy
Microbiocidemetal
Bis(tripropyltin) oxide1067-29-483201NA 829Microbiocide,Organotin, Heavy
Fungicidemetal
Cacodylic acid75-60-51250132Herbicide,Organoarsenic,
DefoliantHeavy metal
Cadmium7440-43-9NA 4602438N/AInorganic-Cadmium,
Heavy metal
Cadmium carbonate513-78-01290193N/AInorganic-Cadmium,
Heavy metal
Cadmium chloride10108-64-21290294N/AInorganic-Cadmium,
Heavy metal
Cadmium cocoate72869-63-7NA 4593085N/AInorganic-Cadmium,
Heavy metal
Cadmium oxide1306-19-0#####NA 130N/AInorganic-Cadmium,
Heavy metal
Cadmium perborateNA 969NA 4613086N/AInorganic-Cadmium,
Heavy metal
Cadmium sebacate93949912903699N/AInorganic-Cadmium,
Heavy metal
Cadmium succinate141-00-41290492N/AInorganic-Cadmium,
Heavy metal
Cadmium sulfate10124-36-412905NA 123N/AInorganic-Cadmium,
Heavy metal
Cadmium yellow pigmentsNA 967NA 4482439N/AInorganic-Cadmium,
Heavy metal
Calcium acid methanearsonate5902-95-413806101Herbicide,Organoarsenic,
DefoliantHeavy metal
Calcium arsenate7778-44-11350196Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide,
Molluscicide
Calcium arsenite53404-59-413602NA 129Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Calcium methanearsonate6423-72-913809NA 136Herbicide,Organoarsenic,
DefoliantHeavy metal
Calcium propanearsonate126-94-313801NA 133Herbicide,Organoarsenic,
DefoliantHeavy metal
Calomel10112-91-152201100FungicideInorganic-Mercury,
Heavy metal
Chloromethoxy propyl1319-86-418401887N/AOrganomercury,
mercuric acetamideHeavy metal
Chromated zinc chlorideNA 1026878011187Insecticide,Inorganic-
Herbicide,Chromium(VI),
MicrobiocideInorganic-Zinc,
Heavy metal
Chromic acetate1066-30-421102NA 172WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Chromic acid7738-94-5211011188WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Chromic oxide1308-38-921103NA 173WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Copper arsenate10103-61-422801NA 178Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Copper
Copper arsenite10290-12-722401NA 177Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Copper
Copper-zinc chromate complex1344-74-721003163Fungicide,Inorganic-
WoodChromium(VI),
PreservativeInorganic-Zinc,
Heavy metal,
Inorganic-Copper
Crag turf fungicide 53112001-20-621006NA 171FungicideInorganic-Cadmium,
(Cd—Cu—Ca—Zn-Chromate)Inorganic-
Chromium(VI),
Inorganic-Zinc,
Heavy metal
Cupric acetoarsenite12002-03-8226012485WoodInorganic-arsenic,
PreservativeHeavy metal,
Inorganic-Copper
Cyhexatin13121-70-5#####1638InsecticideOrganotin, Heavy
metal
Decafentin15652-38-7#####NA 132N/AOrganotin, Heavy
metal
Di(phenylmercuri) ammonium18467-88-466002NA 551N/AOrganomercury,
propionateHeavy metal
Di(phenylmercuric) dodecenyl27236-65-366001501Microbiocide,Organomercury,
succinateFungicideHeavy metal
Dibutyltin dichloride683-18-183123NA 828N/AOrganotin, Heavy
metal
Dodecyl ammonium53404-47-013805857Herbicide,Organoarsenic,
methanearsonateDefoliantHeavy metal
DSMA144-21-813802251Herbicide,Organoarsenic,
DefoliantHeavy metal
Ethylene oxide condensate of56573-85-4NA 1261864Antifoulant,Organotin, Heavy
abietylamine, tributyltinMicrobiocidemetal
chloride
Ethylmercuric phosphate2235-25-841505357N/AOrganomercury,
Heavy metal
Ethylmercurichlorendiimide2597-93-545301NA 383N/AOrganomercury,
Heavy metal
Ethylmercurithiosalicylic acid148-61-878902NA 724FungicideOrganomercury,
Heavy metal
Ethylmercury 2,3-2597-92-441507NA 361FungicideOrganomercury,
dihydroxypropylmercaptideHeavy metal
Ethylmercury acetate109-62-641502NA 357FungicideOrganomercury,
Heavy metal
Ethylmercury bromide107-26-6#####NA 149FungicideOrganomercury,
Heavy metal
Ethylmercury chloride107-27-741503NA 358FungicideOrganomercury,
Heavy metal
Ethylmercury22232-28-641504NA 359MicrobiocideOrganomercury,
pentachlorophenateChlorinated Phenol,
Heavy metal
Fatty acid* - silver complex24927-67-172505NA 675Microbiocide,Inorganic-Silver,
*(100% C8)Fungicide,Heavy metal
Herbicide
Fenbutatin-oxide13356-08-6#####1876InsecticideOrganotin, Heavy
metal
Fentin hydroxide76-87-983601599Fungicide,Organotin, Heavy
Molluscicide,metal
Herbicide
Hydroxymercuri-o-nitrophenol30284-78-7526012606MicrobiocideOrganomercury,
Heavy metal
Hydroxymercuri-o-nitrophenol,1300-34-152602NA 445MicrobiocideOrganomercury,
sodium saltHeavy metal
Hydroxymercurichlorophenols53466-93-646002NA 391MicrobiocideOrganomercury,
Heavy metal
Hydroxymercuriphenyl53466-95-846003NA 392MicrobiocideOrganomercury,
ammonium triethanolamineHeavy metal
Hydroxymercury cresol12379-66-746001NA 390MicrobiocideInorganic-Mercury,
Heavy metal, Phenols
Lactoxymercuriphenyl53466-98-151901NA 429MicrobiocideOrganomercury,
ammonium lactateHeavy metal
Lauric acid, barium cadmium15337-60-7NA 1183676AdjuvantInorganic-Cadmium,
saltHeavy metal
Lead7439-92-1NA 1342638N/AInorganic-Lead,
Heavy metal
Lead acetate301-04-248001NA 415N/AInorganic-Lead,
Heavy metal
Lead arsenate7784-40-913503353Herbicide,Inorganic-arsenic,
Insecticide,Inorganic-lead,
RodenticideHeavy metal
Lead arsenate, basic1327-31-713502354Herbicide,Inorganic-arsenic,
Insecticide,Inorganic-lead,
RodenticideHeavy metal
Lead metasilicateNA 938NA 1381106N/AInorganic-Lead,
Heavy metal
Lead monoxide10190-55-3NA 1231271N/AInorganic-Lead,
Heavy metal
Lead naphthenate61790-14-5480043296N/AInorganic-Lead,
Heavy metal
Litharge1317-36-848002NA 416N/AInorganic-Lead,
Heavy metal
Magnesium arsenate10103-50-113504NA 126Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Manganese arsenate7784-38-513506NA 127Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Mercuric acetate1600-27-752104NA 441N/AInorganic-Mercury,
Heavy metal
Mercuric chloride7487-94-752001372FungicideInorganic-Mercury,
Heavy metal
Mercuric dimethyl15415-64-234808709MicrobiocideInorganic-Mercury,
dithiocarbamateHeavy metal,
Dithiocarbamate
Mercuric iodide7774-29-052003NA 438N/AInorganic-Mercury,
Heavy metal
Mercuric oleate1191-80-6521053276N/AInorganic-Mercury,
Heavy metal
Mercuric oxide21908-53-252102955FungicideInorganic-Mercury,
Heavy metal
Mercury7439-97-652301NA 26N/AInorganic-Mercury,
Heavy metal
Mercury naphthenate1336-96-552101NA 439WoodInorganic-Mercury,
Preservative,Heavy metal
Insecticide,
Fungicide
Mercury pentanedione14024-55-652103NA 440N/AInorganic-Mercury,
Heavy metal
Mercury phenate588-66-952106NA 442N/AInorganic-Mercury,
Heavy metal
Metallic silver7440-22-4725012125Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Methane arsonic acid (MAA)124-58-3#####NA 27N/AOrganoarsenic,
Heavy metal
Methoxyethylmercury acetate151-38-241508NA 362FungicideOrganomercury,
Heavy metal
Methylenebis(thiocyanate) with76397-81-481408NA 785Antifoulant,Organotin, Heavy
TBTOMicrobiocidemetal
Methylmercurichlorendimide5902-79-445302NA 384N/AOrganomercury,
Heavy metal
Methylmercury 2,3-2597-95-751905NA 433FungicideOrganomercury,
dihydroxypropylmercaptideHeavy metal
Methylmercury 8-86-85-151902NA 430FungicideOrganomercury,
hydroxyquinolinateHeavy metal
Methylmercury acetate108-07-651903NA 431FungicideOrganomercury,
Heavy metal
Methylmercury benzoate3626-13-951904NA 432FungicideOrganomercury,
Heavy metal
Methylmercury dicyano502-39-651909454FungicideOrganomercury,
diamideHeavy metal
Methylmercury hydroxide1184-57-251906NA 434FungicideOrganomercury,
Heavy metal
Methylmercury nitrile2597-97-951907NA 435FungicideOrganomercury,
Heavy metal
Methylmercury propionate146088351908NA 436FungicideOrganomercury,
Heavy metal
Monoammonium2321-53-113808NA 135Herbicide,Organoarsenic,
methanearsonateDefoliantHeavy metal
Monotributyltin salicylate4342-30-783122NA 827Antifoulant,Organotin, Heavy
Microbiocidemetal
MSMA2163-80-61380334Herbicide,Organoarsenic,
DefoliantHeavy metal
N-(Ethylmercury)-p-517-16-841506NA 360FungicideOrganomercury,
toluenesulfonanilideHeavy metal
N-(Phenylmercuri) urea2279-64-3#####NA 160HerbicideOrganomercury,
Heavy metal
N-5980-82-566009NA 556FungicideOrganomercury,
(Phenylmercuri)ethylenediamineHeavy metal
o-(Chloromercuri)phenol90-03-9#####NA 135MicrobiocideOrganomercury,
Heavy metal
o-(Hydroxymercuri)benzoic5722-59-852603NA 446MicrobiocideOrganomercury,
acid, cyclic anhydrideHeavy metal
Octylammonium6379-37-91380427Herbicide,Organoarsenic,
methanearsonateDefoliantHeavy metal
p-tert-53433-01-552002NA 437MicrobiocideInorganic-Mercury,
OctylphenoxyethoxyethylHeavy metal
dimethyl benzyl ammonium
mercuric chloride
Paris green12002-03-822601460WoodInorganic-Arsenic,
PreservativeInorganic-Copper,
Heavy metal
Phenarsazine chloride578-94-9639011342N/AOrganoarsenic,
Heavy metal
Phenarsazine oxide4095-45-812602NA 122N/AOrganoarsenic,
Heavy metal
Phenylmercuriammonium53404-68-566023NA 567FungicideOrganomercury,
propionateHeavy metal
Phenylmercuric 2-13302-00-666024NA 568Fungicide,Organomercury,
ethylhexanoateMicrobiocideHeavy metal
Phenylmercuric borate6273-99-066005NA 552Fungicide,Organomercury,
MicrobiocideHeavy metal
Phenylmercuric carbonate53404-69-666006NA 553Fungicide,Organomercury,
MicrobiocideHeavy metal
Phenylmercuric chloride100-56-166007NA 554Fungicide,Organomercury,
MicrobiocideHeavy metal
Phenylmercuric32407-99-166008NA 555Microbiocide,Organomercury,
dimethyldithiocarbamateFungicideDithiocarbamate,
Heavy metal
Phenylmercuric formamide22894-47-966010NA 557Fungicide,Organomercury,
Microbiocide,Heavy metal
Herbicide
Phenylmercuric hydroxide100-57-266011NA 558Fungicide,Organomercury,
Microbiocide,Heavy metal
Herbicide
Phenylmercuric lactate122-64-5660121535Microbiocide,Organomercury,
Fungicide,Heavy metal
Herbicide
Phenylmercuric5822-97-966013NA 559Fungicide,Organomercury,
monoethanolammoniumMicrobiocide,Heavy metal
acetateHerbicide
Phenylmercuric53404-70-966014NA 560Fungicide,Organomercury,
monoethanolammonium lactateMicrobiocide,Heavy metal
Herbicide
Phenylmercuric naphthenate31632-68-566015NA 561WoodOrganomercury,
Preservative,Heavy metal
Insecticide,
Fungicide
Phenylmercuric nitrate55-68-566016477Microbiocide,Organomercury,
Fungicide,Heavy metal
Herbicide
Phenylmercuric octanoate13864-38-566025NA 569Fungicide,Organomercury,
Microbiocide,Heavy metal
Herbicide
Phenylmercuric oleate104-60-966022853Microbiocide,Organomercury,
Fungicide,Heavy metal
Herbicide
Phenylmercuric propionate103-27-566018NA 563Fungicide,Organomercury,
Microbiocide,Heavy metal
Herbicide
Phenylmercuric salicylate28086-13-766019NA 564Fungicide,Organomercury,
Microbiocide,Heavy metal
Herbicide
Phenylmercuric thiocyanate16751-55-666020NA 565Microbiocide,Organomercury,
Fungicide,Heavy metal
Herbicide
Phenylmercuritriethanolammonium23319-66-666021NA 566Microbiocide,Organomercury,
lactateFungicide,Heavy metal
Herbicide
Phenylmercury 8-14354-56-466017NA 562Fungicide,Organomercury,
hydroxyquinolinolateMicrobiocide,Heavy metal
Herbicide
Phenylmercury benzoate94-43-951900NA 428Fungicide,Organomercury,
Microbiocide,Heavy metal
Herbicide
PMA62-38-466003491Fungicide,Organomercury,
Microbiocide,Heavy metal
Herbicide
PMA, other relatedNA 1106NA 16490491Fungicide,Organomercury,
Herbicide,Heavy metal
Microbiocide
PMAA53404-67-466004492Fungicide,Organomercury,
MicrobiocideHeavy metal
Poly (methylmethacrylate-co-26354-18-7831195075Antifoulant,Organotin, Heavy
tributyltin methacrylate)Microbiocidemetal
Potassium arsenite10124-50-213605NA 131Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Potassium arsenite13464-35-213605NA 132Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Potassium chromate7789-00-668301700WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Potassium hexafluoroarsenate17029-22-0#####NA 160N/AInorganic-arsenic,
Heavy metal
Potassium mercuric iodide7783-33-752107NA 443N/AInorganic-Mercury,
Heavy metal
Pyridylmercuric acetate1334-77-669501NA 661N/AOrganomercury,
Heavy metal
Pyridylmercuric chloride1334-75-469502NA 662N/AOrganomercury,
Heavy metal
Silver acetate563-63-372507NA 676Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver carbonate534-16-772509NA 678Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver chloride7783-90-6725062324Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver copper zeolite130328-19-7#####NA 110MicrobiocideInorganic-Silver,
Heavy metal,
Inorganic-Copper
Silver fluoride7775-41-972502NA 674Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver iodide, colloidal7783-96-2NA 1241556Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver nitrate7761-88-8725032856Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide,
Plant Growth
Regulator
Silver orthophosphate7784-09-072510NA 679Microbiocide,Inorganic-Silver,
(Ag3PO4)Fungicide,Heavy metal
Herbicide
Silver oxide (Ag4O4)1301-96-8#####NA 111Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver oxide (Ag4O4)155645-89-9#####NA 111Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver sodium hydrogenNA 116672560NA 164MicrobiocideInorganic-Silver,
zirconium phosphateHeavy metal
(Ag0.18Na0.57H0.25Zr2(PO4)3)
Silver thiocyanate1701-93-568203NA 606Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver thiuronium acrylate copolymer53404-00-572701NA 681Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver zeolite130328-18-6#####NA 125MicrobiocideInorganic-Silver,
Heavy metal
Silver zinc zeolite130328-20-0#####NA 111MicrobiocideInorganic-Silver,
Inorganic-Zinc,
Heavy metal
Silver, ionic14701-21-4NA 1695150Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Sodium arsenate13464-38-513505283Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Sodium arsenite7784-46-513603534Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide,
Fungicide
Sodium cacodylate124-65-2125021673Herbicide,Organoarsenic,
Defoliant,Heavy metal
Rodenticide
Sodium chromate2144646683031241WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Sodium dichromate10588-01-9683043395WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Sodium54-64-878901NA 723N/AOrganomercury,
ethylmercurithiosalicylateHeavy metal
Sodium pyroarsenate13464-42-1134012864WoodInorganic-arsenic,
Preservative,Heavy metal
Fungicide
Sodium silver thiosulfateNA 1398NA 197NA 196HerbicideInorganic-Silver,
Heavy metal
Sodium thioarsenate17367-56-513507NA 128N/AInorganic-arsenic,
(Na3AsO3S)Heavy metal
Thallium(I) sulfate7446-18-680001NA 35RodenticideInorganic, Heavy
metal
Tolylmercuric acetate1300-78-3#####NA 150FungicideOrganomercury,
Heavy metal
Tri-n-butyltin maleate14275-57-1831182185Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin acetate56-36-0831052097Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin acrylate13331-52-783121NA 826Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin benzoate4342-36-3831061114Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin chloride1461-22-9831071891Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin chloride complex of56573-85-4831081412Antifoulant,Organotin, Heavy
ethylene oxide condensate ofMicrobiocidemetal
abietylamine
Tributyltin chloride,NA 1012NA 970938Antifoulant,Organotin, Heavy
myristylamine saltMicrobiocidemetal
Tributyltin fluoride29131831121030Antifoulant,Organotin, Heavy
Microbiocide,metal
Fungicide
Tributyltin isopropyl succinate53404-82-3831151115Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin linoleate24124-25-2831091116Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin methacrylate2155-70-6831202179Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin monopropylene53466-85-6831101985Antifoulant,Organotin, Heavy
glycol maleateMicrobiocidemetal
Tributyltin neodecanoate28801-69-6831111035Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin oxide56-35-983001569Antifoulant,Organotin, Heavy
Microbiocide,metal
Molluscicide,
Fungicide
Tributyltin resinate13387-91-2831141732Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin sulfide4808-30-4831131352Antifoulant,Organotin, Heavy
Microbiocidemetal
Triethanolamine cacodylate69484-14-612503NA 121Herbicide,Organoarsenic,
DefoliantHeavy metal
Triethanolamine5902-97-613807NA 134Herbicide,Organoarsenic,
methanearsonateDefoliantHeavy metal
Trimethyltin chloride1066-45-1#####NA 161N/AOrganotin, Heavy
metal
Triphenylbismuthine603-33-882801NA 821N/AHeavy metal
Triphenylbismuthine dichloride594-30-982802NA 822N/AHeavy metal
Triphenyltin acetate900-95-8#####NA 153Fungicide,Organotin, Heavy
Herbicidemetal
Triphenyltin chloride639-58-7#####NA 153N/AOrganotin, Heavy
metal
Triphenyltin fluoride379-52-2836022212AntifoulantOrganotin, Heavy
metal
Tripropyltin methacrylate4154-35-283202NA 830N/AOrganotin, Heavy
metal
Zinc arsenate13464-44-313301NA 125Herbicide,Inorganic-Arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Zinc
Zinc arsenite28837-97-013604NA 130Herbicide,Inorganic-Arsenic,
Insecticide,Inorganic-Zinc,
RodenticideHeavy metal
Zinc mercury chromate22323-45-121004NA 170FungicideInorganic-Mercury,
Inorganic-
chromium(VI),
Inorganic-Zinc,
Heavy metal
Ammonium arsenate7784-44-3136012380Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic7440-38-2NA 121710Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic acid7778-39-4680140Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic disulfide56320-22-06901NA 98Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic pentoxide1303-28-26802631Fungicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide,
Herbicide
Arsenic sulfide12612-21-46901NA 99Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic trioxide1327-53-3700142Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsenic trisulfide1303-33-96901NA 97Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Arsonic acid, ammonium salt58829-95-1#####NA 105Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Wood
Preservative
Basic copper arsenate16102-92-4#####NA 132Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Copper
Calcium arsenate7778-44-11350196Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide,
Molluscicide
Calcium arsenite53404-59-413602NA 129Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Copper arsenate10103-61-422801NA 178Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Copper
Copper arsenite10290-12-722401NA 177Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Copper
Cupric acetoarsenite12002-03-8226012485WoodInorganic-arsenic,
PreservativeHeavy metal,
Inorganic-Copper
Lead arsenate7784-40-913503353Herbicide,Inorganic-arsenic,
Insecticide,Inorganic-lead,
RodenticideHeavy metal
Lead arsenate, basic1327-31-713502354Herbicide,Inorganic-arsenic,
Insecticide,Inorganic-lead,
RodenticideHeavy metal
Magnesium arsenate10103-50-113504NA 126Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Manganese arsenate7784-38-513506NA 127Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Paris green12002-03-822601460WoodInorganic-Arsenic,
PreservativeInorganic-Copper,
Heavy metal
Potassium arsenite10124-50-213605NA 131Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Potassium arsenite13464-35-213605NA 132Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Potassium hexafluoroarsenate17029-22-0#####NA 160N/AInorganic-arsenic,
Heavy metal
Sodium arsenate13464-38-513505283Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide
Sodium arsenite7784-46-513603534Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal
Rodenticide,
Fungicide
Sodium pyroarsenate13464-42-1134012864WoodInorganic-arsenic,
Preservative,Heavy metal
Fungicide
Sodium thioarsenate17367-56-513507NA 128N/AInorganic-arsenic,
(Na3AsO3S)Heavy metal
Zinc arsenate13464-44-313301NA 125Herbicide,Inorganic-Arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Zinc
Zinc arsenite28837-97-013604NA 130Herbicide,Inorganic-Arsenic,
Insecticide,Inorganic-Zinc,
RodenticideHeavy metal
Antimony7440-36-0NA 5162388N/AAntimony
Antimony potassium tartrate28300-74-562013057InsecticideAntimony
Diphenylstibene 2-5035-58-56202NA 82MicrobiocideAntimony
ethylhexanoate
10,10′-Oxybisphenoxyarsine58-36-6126011402Fungicide,Organoarsenic,
MicrobiocideHeavy metal
Arsenosobenzene637-03-67101NA 100N/AOrganoarsenic,
Heavy metal
Arsonic acid, (4-aminophenyl)-98-50-0#####NA 109N/AOrganoarsenic,
Heavy metal
Cacodylic acid75-60-51250132Herbicide,Organoarsenic,
DefoliantHeavy metal
Calcium acid methanearsonate5902-95-413806101Herbicide,Organoarsenic,
DefoliantHeavy metal
Calcium methanearsonate6423-72-913809NA 136Herbicide,Organoarsenic,
DefoliantHeavy metal
Calcium propanearsonate126-94-313801NA 133Herbicide,Organoarsenic,
DefoliantHeavy metal
Dodecyl ammonium53404-47-013805857Herbicide,Organoarsenic,
methanearsonateDefoliantHeavy metal
DSMA144-21-813802251Herbicide,Organoarsenic,
DefoliantHeavy metal
Methane arsonic acid (MAA)124-58-3#####NA 27N/AOrganoarsenic,
Heavy metal
Monoammonium2321-53-113808NA 135Herbicide,Organoarsenic,
methanearsonateDefoliantHeavy metal
MSMA2163-80-61380334Herbicide,Organoarsenic,
DefoliantHeavy metal
Octylammonium6379-37-91380427Herbicide,Organoarsenic,
methanearsonateDefoliantHeavy metal
Phenarsazine chloride578-94-9639011342N/AOrganoarsenic,
Heavy metal
Phenarsazine oxide4095-45-812602NA 122N/AOrganoarsenic,
Heavy metal
Sodium cacodylate124-65-2125021673Herbicide,Organoarsenic,
Defoliant,Heavy metal
Rodenticide
Triethanolamine cacodylate69484-14-612503NA 121Herbicide,Organoarsenic,
DefoliantHeavy metal
Triethanolamine5902-97-613807NA 134Herbicide,Organoarsenic,
methanearsonateDefoliantHeavy metal
Calomel10112-91-152201100FungicideInorganic-Mercury,
Heavy metal
Hydroxymercury cresol12379-66-746001NA 390MicrobiocideInorganic-Mercury,
Heavy metal, Phenols
Mercuric acetate1600-27-752104NA 441N/AInorganic-Mercury,
Heavy metal
Mercuric chloride7487-94-752001372FungicideInorganic-Mercury,
Heavy metal
Mercuric dimethyl15415-64-234808709MicrobiocideInorganic-Mercury,
dithiocarbamateHeavy metal,
Dithiocarbamate
Mercuric iodide7774-29-052003NA 438N/AInorganic-Mercury,
Heavy metal
Mercuric oleate1191-80-6521053276N/AInorganic-Mercury,
Heavy metal
Mercuric oxide21908-53-252102955FungicideInorganic-Mercury,
Heavy metal
Mercury7439-97-652301NA 26N/AInorganic-Mercury,
Heavy metal
Mercury naphthenate1336-96-552101NA 439WoodInorganic-Mercury,
Preservative,Heavy metal
Insecticide,
Fungicide
Mercury pentanedione14024-55-652103NA 440N/AInorganic-Mercury,
Heavy metal
Mercury phenate588-66-952106NA 442N/AInorganic-Mercury,
Heavy metal
p-tert-53433-01-552002NA 437MicrobiocideInorganic-Mercury,
OctylphenoxyethoxyethylHeavy metal
dimethyl benzyl ammonium
mercuric chloride
Potassium mercuric iodide7783-33-752107NA 443N/AInorganic-Mercury,
Heavy metal
Zinc mercury chromate22323-45-121004NA 170FungicideInorganic-Mercury,
Inorganic-
chromium(VI),
Inorganic-Zinc,
Heavy metal
(3-Ethoxypropyl)mercury6012-84-6#####NA 147FungicideOrganomercury,
bromideHeavy metal
(3-Hydroxy-2-69653-69-6#####NA 153N/AOrganomercury,
methoxypropyl)mercuricHeavy metal
acetate
2-(acetoxymercuri)ethanol4665-55-841501NA 356N/AOrganomercury,
Heavy metal
3-(Hydroxymercuri)-4-nitro-o-53404-55-052604NA 447MicrobiocideOrganomercury,
phenol, sodium saltHeavy metal
Chloromethoxy propyl1319-86-418401887N/AOrganomercury,
mercuric acetamideHeavy metal
Di(phenylmercuri) ammonium18467-88-466002NA 551N/AOrganomercury,
propionateHeavy metal
Di(phenylmercuric) dodecenyl27236-65-366001501Microbiocide,Organomercury,
succinateFungicideHeavy metal
Ethylmercuric phosphate2235-25-841505357N/AOrganomercury,
Heavy metal
Ethylmercurichlorendiimide2597-93-545301NA 383N/AOrganomercury,
Heavy metal
Ethylmercurithiosalicylic acid148-61-878902NA 724FungicideOrganomercury,
Heavy metal
Ethylmercury 2,3-2597-92-441507NA 361FungicideOrganomercury,
dihydroxypropylmercaptideHeavy metal
Ethylmercury acetate109-62-641502NA 357FungicideOrganomercury,
Heavy metal
Ethylmercury bromide107-26-6#####NA 149FungicideOrganomercury,
Heavy metal
Ethylmercury chloride107-27-741503NA 358FungicideOrganomercury,
Heavy metal
Ethylmercury22232-28-641504NA 359MicrobiocideOrganomercury,
pentachlorophenateChlorinated Phenol,
Heavy metal
Hydroxymercuri-o-nitrophenol30284-78-7526012606MicrobiocideOrganomercury,
Heavy metal
Hydroxymercuri-o-nitrophenol,1300-34-152602NA 445MicrobiocideOrganomercury,
sodium saltHeavy metal
Hydroxymercurichlorophenols53466-93-646002NA 391MicrobiocideOrganomercury,
Heavy metal
Hydroxymercuriphenyl53466-95-846003NA 392MicrobiocideOrganomercury,
ammonium triethanolamineHeavy metal
Lactoxymercuriphenyl53466-98-151901NA 429MicrobiocideOrganomercury,
ammonium lactateHeavy metal
Methoxyethyl mercury chloride123-88-6NA 212NA 211FungicideOrganomercury
Methoxyethyl mercury silicate64491-92-5NA 208NA 208FungicideOrganomercury
Methoxyethylmercury acetate151-38-241508NA 362FungicideOrganomercury,
Heavy metal
Methylmercurichlorendimide5902-79-445302NA 384N/AOrganomercury,
Heavy metal
Methylmercury 2,3-2597-95-751905NA 433FungicideOrganomercury,
dihydroxypropylmercaptideHeavy metal
Methylmercury 8-86-85-151902NA 430FungicideOrganomercury,
hydroxyquinolinateHeavy metal
Methylmercury acetate108-07-651903NA 431FungicideOrganomercury,
Heavy metal
Methylmercury benzoate3626-13-951904NA 432FungicideOrganomercury,
Heavy metal
Methylmercury dicyano502-39-651909454FungicideOrganomercury,
diamideHeavy metal
Methylmercury hydroxide1184-57-251906NA 434FungicideOrganomercury,
Heavy metal
Methylmercury nitrile2597-97-951907NA 435FungicideOrganomercury,
Heavy metal
Methylmercury propionate146088351908NA 436FungicideOrganomercury,
Heavy metal
N-(Ethylmercury)-p-517-16-841506NA 360FungicideOrganomercury,
toluenesulfonanilideHeavy metal
N-(Phenylmercuri) urea2279-64-3#####NA 160HerbicideOrganomercury,
Heavy metal
N-5980-82-566009NA 556FungicideOrganomercury,
(Phenylmercuri)ethylenediamineHeavy metal
o-(Chloromercuri)phenol90-03-9#####NA 135MicrobiocideOrganomercury,
Heavy metal
o-(Hydroxymercuri)benzoic5722-59-852603NA 446MicrobiocideOrganomercury,
acid, cyclic anhydrideHeavy metal
Phenylmercuriammonium53404-68-566023NA 567FungicideOrganomercury,
propionateHeavy metal
Phenylmercuric 2-13302-00-666024NA 568Fungicide,Organomercury,
ethylhexanoateMicrobiocideHeavy metal
Phenylmercuric borate6273-99-066005NA 552Fungicide,Organomercury,
MicrobiocideHeavy metal
Phenylmercuric carbonate53404-69-666006NA 553Fungicide,Organomercury,
MicrobiocideHeavy metal
Phenylmercuric chloride100-56-166007NA 554Fungicide,Organomercury,
MicrobiocideHeavy metal
Phenylmercuric32407-99-166008NA 555Microbiocide,Organomercury,
dimethyldithiocarbamateFungicideDithiocarbamate,
Heavy metal
Phenylmercuric formamide22894-47-966010NA 557Fungicide,Organomercury,
Microbiocide,Heavy metal
Herbicide
Phenylmercuric hydroxide100-57-266011NA 558Fungicide,Organomercury,
Microbiocide,Heavy metal
Herbicide
Phenylmercuric lactate122-64-5660121535Microbiocide,Organomercury,
Fungicide,Heavy metal
Herbicide
Phenylmercuric5822-97-966013NA 559Fungicide,Organomercury,
monoethanolammoniumMicrobiocide,Heavy metal
acetateHerbicide
Phenylmercuric53404-70-966014NA 560Fungicide,Organomercury,
monoethanolammonium lactateMicrobiocide,Heavy metal
Herbicide
Phenylmercuric naphthenate31632-68-566015NA 561WoodOrganomercury,
Preservative,Heavy metal
Insecticide,
Fungicide
Phenylmercuric nitrate55-68-566016477Microbiocide,Organomercury,
Fungicide,Heavy metal
Herbicide
Phenylmercuric octanoate13864-38-566025NA 569Fungicide,Organomercury,
Microbiocide,Heavy metal
Herbicide
Phenylmercuric oleate104-60-966022853Microbiocide,Organomercury,
Fungicide,Heavy metal
Herbicide
Phenylmercuric propionate103-27-566018NA 563Fungicide,Organomercury,
Microbiocide,Heavy metal
Herbicide
Phenylmercuric salicylate28086-13-766019NA 564Fungicide,Organomercury,
Microbiocide,Heavy metal
Herbicide
Phenylmercuric thiocyanate16751-55-666020NA 565Microbiocide,Organomercury,
Fungicide,Heavy metal
Herbicide
Phenylmercuritriethanolammonium23319-66-666021NA 566Microbiocide,Organomercury,
lactateFungicide,Heavy metal
Herbicide
Phenylmercury 8-14354-56-466017NA 562Fungicide,Organomercury,
hydroxyquinolinolateMicrobiocide,Heavy metal
Herbicide
Phenylmercury benzoate94-43-951900NA 428Fungicide,Organomercury,
Microbiocide,Heavy metal
Herbicide
Phenylmercury nitrate2227736NA 209NA 208FungicideOrganomercury
PMA62-38-466003491Fungicide,Organomercury,
Microbiocide,Heavy metal
Herbicide
PMA, other relatedNA 1106NA 16490491Fungicide,Organomercury,
Herbicide,Heavy metal
Microbiocide
PMAA53404-67-466004492Fungicide,Organomercury,
MicrobiocideHeavy metal
Pyridylmercuric acetate1334-77-669501NA 661N/AOrganomercury,
Heavy metal
Pyridylmercuric chloride1334-75-469502NA 662N/AOrganomercury,
Heavy metal
Sodium54-64-878901NA 723N/AOrganomercury,
ethylmercurithiosalicylateHeavy metal
Tolylmercuric acetate1300-78-3#####NA 150FungicideOrganomercury,
Heavy metal
Anilinocadmium dilactate19651-91-364601NA 548N/AInorganic-Cadmium,
Heavy metal
Cadmium7440-43-9NA 4602438N/AInorganic-Cadmium,
Heavy metal
Cadmium carbonate513-78-01290193N/AInorganic-Cadmium,
Heavy metal
Cadmium chloride10108-64-21290294N/AInorganic-Cadmium,
Heavy metal
Cadmium cocoate72869-63-7NA 4593085N/AInorganic-Cadmium,
Heavy metal
Cadmium oxide1306-19-0#####NA 130N/AInorganic-Cadmium,
Heavy metal
Cadmium perborateNA 969NA 4613086N/AInorganic-Cadmium,
Heavy metal
Cadmium sebacate93949912903699N/AInorganic-Cadmium,
Heavy metal
Cadmium succinate141-00-41290492N/AInorganic-Cadmium,
Heavy metal
Cadmium sulfate10124-36-412905NA 123N/AInorganic-Cadmium,
Heavy metal
Cadmium yellow pigmentsNA 967NA 4482439N/AInorganic-Cadmium,
Heavy metal
Crag turf fungicide 53112001-20-621006NA 171FungicideInorganic-Cadmium,
(Cd—Cu—Ca—Zn-Chromate)Inorganic-
Chromium(VI),
Inorganic-Zinc,
Heavy metal
Lauric acid, barium cadmium15337-60-7NA 1183676AdjuvantInorganic-Cadmium,
saltHeavy metal
Ammonium dichromate214970168305NA 607WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Chromated zinc chlorideNA 1026878011187Insecticide,Inorganic-
Herbicide,Chromium(VI),
MicrobiocideInorganic-Zinc,
Heavy metal
Chromic acetate1066-30-421102NA 172WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Chromic acid7738-94-5211011188WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Chromic oxide1308-38-921103NA 173WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Copper-zinc chromate complex1344-74-721003163Fungicide,Inorganic-
WoodChromium(VI),
PreservativeInorganic-Zinc,
Heavy metal,
Inorganic-Copper
Crag turf fungicide 53112001-20-621006NA 171FungicideInorganic-Cadmium,
(Cd—Cu—Ca—Zn-Chromate)Inorganic-
Chromium(VI),
Inorganic-Zinc,
Heavy metal
Potassium chromate7789-00-668301700WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Potassium dichromate7778-50-9683022167WoodInorganic-
PreservativeChromium(VI)
Sodium bichromate dihydrate7789-12-0683063980WoodInorganic-
PreservativeChromium(VI),
Inorganic
Sodium chromate2144646683031241WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Sodium dichromate10588-01-9683043395WoodInorganic-
PreservativeChromium(VI),
Heavy metal
Zinc mercury chromate22323-45-121004NA 170FungicideInorganic-Mercury,
Inorganic-
chromium(VI),
Inorganic-Zinc,
Heavy metal
Acetic acid, copper (2+) salt142-71-2NA 6973013N/AInorganic-Copper
Basic copper arsenate16102-92-4#####NA 132Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Copper
Bordeaux mixtureNA 240NA 47880FungicideInorganic-Copper
Chlorophyllin11006-34-1NA 191NA 190Fungicide,Inorganic-Copper,
MicrobiocideBotanical
Copper7440-50-822501714FungicideInorganic-Copper
Copper (from triethanolamine82027-59-624403NA 198AlgaecideInorganic-Copper
complex)
Copper 2-ethylhexanoate22221-10-9412012235FungicideInorganic-Copper
Copper 3-phenylsalicylate125068223801NA 191N/AInorganic-Copper
Copper 8-quinolinoleate10380-28-624002159Fungicide,Inorganic-Copper
Microbiocide
Copper abietate10248-55-223301NA 184FungicideInorganic-Copper
Copper acetate83163244002147FungicideInorganic-Copper
Copper ammonium acetateNA 1544NA 225NA 225FungicideInorganic-Copper
Copper ammonium carbonate33113-08-5227031762FungicideInorganic-Copper
Copper ammonium complex16828-95-8227023550FungicideInorganic-Copper
Copper arsenate10103-61-422801NA 178Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Copper
Copper arsenite10290-12-722401NA 177Herbicide,Inorganic-arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Copper
Copper as elemental from50376-91-524404NA 199N/AInorganic-Copper
copper - etidronic acid complex
Copper beta cyclodextrinNA 1366NA 193NA 193FungicideInorganic-Copper
hydroxide
Copper bronze powder7440-50-8225011457AntifoulantInorganic-Copper
Copper carbonate, basic1184-64-12290160Fungicide,Inorganic-Copper
Algaecide,
Insecticide
Copper chloride (anhydrous)1344-67-823802NA 192N/AInorganic-Copper
Copper chloride (dihydrate)10125-13-023701NA 190N/AInorganic-Copper
Copper citrate10402-15-0440051406N/AInorganic-Copper
Copper citrate chelateNA 961NA 3873547N/AInorganic-Copper
Copper complex with ammonia67989-88-2#####NA 130FungicideInorganic-Copper
and ethylene diamine
tetraacetate
Copper cresylate12379-42-923001NA 181FungicideInorganic-Copper
Copper53404-24-341202NA 349N/AInorganic-Copper
dehydroabietylammonium 2-
ethylhexanoate
Copper dihydrazinium sulfate33271-65-750504753N/AInorganic-Copper
Copper ethanolamine complex14215-52-224409NA 201AlgaecideInorganic-Copper
Copper ethanolamineNA 1044NA 1463551AlgaecideInorganic-Copper
complexes, mixed
Copper ethylenediamine13426-91-0244073549HerbicideInorganic-Copper
complex
Copper gluconate chelate814-91-5233053548N/AInorganic-Copper
Copper hydrazinium sulfate53433-02-650501NA 418FungicideInorganic-Copper
Copper hydroxide20427-59-223401151Fungicide,Inorganic-Copper
Microbiocide,
Nematicide
Copper hydroxide - NA 1017NA 1051826N/AInorganic-Copper
triethanolamine complex
Copper isodecanoate84082-88-241221NA 354N/AInorganic-Copper
Copper isononanoate72915-82-341211NA 352N/AInorganic-Copper
Copper isooctanoate88859-94-341204NA 350N/AInorganic-Copper
Copper lactate16039-52-423302NA 185N/AInorganic-Copper
Copper linoleate7721-15-5233031110N/AInorganic-Copper
Copper metaborate39290-85-222802NA 179N/AInorganic-Copper
Copper monoethanolamineNA 960NA 3843552N/AInorganic-Copper
complex
Copper naphthenate1338-02-923102153WoodInorganic-Copper
Preservative,
Insecticide,
Fungicide, Dog
and Cat
Repellent
Copper naphthenate1338-02-96000NA 172WoodInorganic-Copper
Preservative,
Insecticide,
Fungicide, Dog
and Cat
Repellent
Copper naphthenate1338-02-96300NA 172WoodInorganic-Copper
Preservative,
Insecticide,
Fungicide, Dog
and Cat
Repellent
Copper nitroacetate22221-12-123201NA 183N/AInorganic-Copper
Copper octanoate20543-04-8233065225FungicideInorganic-Copper
Copper oleate10402-16-123304154FungicideInorganic-Copper
Copper oxide (ic)1317-38-0424012231Fungicide,Inorganic-Copper
Insecticide
Copper oxide (ous)1317-39-125601175Fungicide,Inorganic-Copper
Insecticide
Copper oxychloride1332-40-78001156FungicideInorganic-Copper
Copper oxychloride1332-65-623501NA 186FungicideInorganic-Copper
(Cu2Cl(OH)3)
Copper oxychloride sulfate8012-69-923503158FungicideInorganic-Copper
Copper oxysulfate12158-97-323504NA 188N/AInorganic-Copper
Copper oxysulfate82010-79-523504NA 189N/AInorganic-Copper
Copper pentachlorophenate15773-35-063011NA 512WoodChlorinated Phenol,
Preservative,Inorganic-Copper
Microbiocide,
Algaecide,
Fungicide
Copper phosphate10103-48-722902NA 180N/AInorganic-Copper
Copper phthalocyanine147-14-8NA 3812479DyeInorganic-Copper
Copper pyrophosphate10102-90-669701NA 663N/AInorganic-Copper
Copper salts of fatty and rosin9007-39-023104155FungicideInorganic-Copper
acids
Copper salts of the acids of tall61789-22-823103NA 182N/AInorganic-Copper
oil
Copper silicate1344-72-524301NA 197N/AInorganic-Copper
Copper sodium sulfate-NA 1023NA 121755N/AInorganic-Copper
phosphate complex
Copper sulfate (anhydrous)7758-98-7244081778Fungicide,Inorganic-Copper
Algaecide,
Molluscicide
Copper sulfate (basic)1344-73-68101162Fungicide,Inorganic-Copper
Algaecide,
Molluscicide
Copper sulfate (pentahydrate)7758-99-824401161Algaecide,Inorganic-Copper
Fungicide,
Insecticide,
Water
Treatment,
Molluscicide,
Nematicide
Copper sulfate ethyleneNA 1036NA 1322480N/AInorganic-Copper
diamine
Copper sulfate, monohydrate10257-54-2244021789Fungicide,Inorganic-Copper
Algaecide,
Molluscicide
Copper sulfate, tri-basicNA 1384NA 195NA 194Herbicide,Inorganic-Copper
Algaecide,
Fungicide,
Water
Treatment
Copper triethanolamine68027-59-6NA 1251615AlgaecideInorganic-Copper
complex
Copper-zinc chromate complex1344-74-721003163Fungicide,Inorganic-
WoodChromium(VI),
PreservativeInorganic-Zinc,
Heavy metal,
Inorganic-Copper
Copper-zinc sulfate complex55072-57-68102164FungicideInorganic-Zinc,
Inorganic-Copper
Copper-zinc sulfate complex,NA 959NA 3821751FungicideInorganic-Zinc,
monohydrateInorganic-Copper
CuprammoniumNA 1382NA 195NA 194FungicideInorganic-Copper
Cupric acetoarsenite12002-03-8226012485WoodInorganic-arsenic,
PreservativeHeavy metal,
Inorganic-Copper
Cupric ferric subsulfate12168-20-642402NA 365MolluscicideInorganic-Copper
complex
Cupric fluosilicate12062-24-775309NA 692InsecticideInorganic-Copper
Cupric gluconate527-09-3244053117FungicideInorganic-Copper
Cupric nitrate3251-23-8761023118N/AInorganic-Copper
Cuprous and cupric oxide,82010-82-042403NA 366N/AInorganic-Copper
mixed
Cuprous chloride (Cu2Cl2)7758-89-6#####5597FungicideInorganic-Copper
Cuprous iodide7681-65-4#####NA 902N/AInorganic-Copper
Cuprous sulfide22205-45-4#####NA 124N/AInorganic-Copper
Cuprous thiocyanate1111-67-7256022108MicrobiocideInorganic-Copper
Device (swimming poolNA 1504NA 222NA 222AlgaecideInorganic-Copper
algaecide, copper generating)
no guarantee required
Dihydrogen54453-03-124406NA 200N/AInorganic-Copper
{ethylenediaminetetraacetato(4-)}
cuprate(2-)
Disodium EDTA-copper14025-15-1NA 2963173N/AInorganic-Copper
EDTA diammonium copper7379-26-2391171613AlgaecideInorganic-Copper
salt
EDTA, copper complex12276-01-6391051135AlgaecideInorganic-Copper
Lignin sulfonic acid, copperNA 933NA 1261925N/AInorganic-Copper
salt
Malachite (copper equivalent1319-53-5#####NA 155N/AInorganic-Copper
57%)
Mixed copper chelates orNA 1437NA 213NA 212FungicideInorganic-Copper
complex blend of copper salts
N-(2-hydroxyethyl) ethyleneNA 1025NA 1221130N/AInorganic-Copper
diamine triacetic acid, copper
salt
Neodecanoic acid, copper salt50315-14-597503NA 854N/AInorganic-Copper
Paris green12002-03-822601460WoodInorganic-Arsenic,
PreservativeInorganic-Copper,
Heavy metal
Silver copper zeolite130328-19-7#####NA 110MicrobiocideInorganic-Silver,
Heavy metal,
Inorganic-Copper
Tetracopper calcium1336-15-823502NA 187FungicideInorganic-Copper
oxychloride
Tricopper dichloride7076-63-3#####NA 152MicrobiocideDithiocarbamate,
dimethyldithiocarbamateInorganic-Copper
Azocyclotin41083-11-8#####2408InsecticideOrganotin, Heavy
metal
Bis (tributyltin) adipate7437-35-6831171990Antifoulant,Organotin, Heavy
Microbiocidemetal
Bis (tributyltin) sulfide4808-30-4831131886Antifoulant,Organotin, Heavy
Microbiocidemetal
Bis (tributyltin) sulfoneNA 970NA 4761665Antifoulant,Organotin, Heavy
Microbiocidemetal
Bis(tributyltin)12379-54-383101NA 824Antifoulant,Organotin, Heavy
dodecenylsuccinateMicrobiocidemetal
Bis(tributyltin) salicylate22330-14-9831025074Antifoulant,Organotin, Heavy
Microbiocidemetal
Bis(tributyltin) succinate4644-96-68310374Antifoulant,Organotin, Heavy
Microbiocidemetal
Bis(tributyltin) sulfosalicylate4419-22-183104NA 825Antifoulant,Organotin, Heavy
Microbiocidemetal
Bis(tripropyltin) oxide1067-29-483201NA 829Microbiocide,Organotin, Heavy
Fungicidemetal
Cyhexatin13121-70-5#####1638InsecticideOrganotin, Heavy
metal
Decafentin15652-38-7#####NA 132N/AOrganotin, Heavy
metal
Dibutyltin dichloride683-18-183123NA 828N/AOrganotin, Heavy
metal
Ethylene oxide condensate of56573-85-4NA 1261864Antifoulant,Organotin, Heavy
abietylamine, tributyltinMicrobiocidemetal
chloride
Fenbutatin-oxide13356-08-6#####1876InsecticideOrganotin, Heavy
metal
Fentin hydroxide76-87-983601599Fungicide,Organotin, Heavy
Molluscicide,metal
Herbicide
Methylenebis(thiocyanate) with76397-81-481408NA 785Antifoulant,Organotin, Heavy
TBTOMicrobiocidemetal
Monotributylin salicylate4342-30-783122NA 827Antifoulant,Organotin, Heavy
Microbiocidemetal
Poly (methylmethacrylate-co-26354-18-7831195075Antifoulant,Organotin, Heavy
tributyltin methacrylate)Microbiocidemetal
Tin Acrylate Polymers RC 626NA 1444NA 214NA 213AntifoulantOrganotin
& RC 627
Tri-n-butyltin maleate14275-57-1831182185Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin acetate56-36-0831052097Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin acrylate13331-52-783121NA 826Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin benzoate4342-36-3831061114Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin chloride1461-22-9831071891Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin chloride complex of56573-85-4831081412Antifoulant,Organotin, Heavy
ethylene oxide condensate ofMicrobiocidemetal
abietylamine
Tributyltin chloride,NA 1012NA 970938Antifoulant,Organotin, Heavy
myristylamine saltMicrobiocidemetal
Tributyltin fluoride29131831121030Antifoulant,Organotin, Heavy
Microbiocide,metal
Fungicide
Tributyltin isopropyl succinate53404-82-3831151115Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin linoleate24124-25-2831091116Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin methacrylate2155-70-6831202179Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin monopropylene53466-85-6831101985Antifoulant,Organotin, Heavy
glycol maleateMicrobiocidemetal
Tributyltin naphthenate85409-17-2NA 211NA 210FungicideOrganotin
Tributyltin neodecanoate28801-69-6831111035Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin oxide56-35-983001569Antifoulant,Organotin, Heavy
Microbiocide,metal
Molluscicide,
Fungicide
Tributyltin resinate13387-91-2831141732Antifoulant,Organotin, Heavy
Microbiocidemetal
Tributyltin sulfide4808-30-4831131352Antifoulant,Organotin, Heavy
Microbiocidemetal
Trimethyltin chloride1066-45-1#####NA 161N/AOrganotin, Heavy
metal
Triphenyltin acetate900-95-8#####NA 153Fungicide,Organotin, Heavy
Herbicidemetal
Triphenyltin chloride639-58-7#####NA 153N/AOrganotin, Heavy
metal
Triphenyltin fluoride379-52-2836022212AntifoulantOrganotin, Heavy
metal
Tripropyltin methacrylate4154-35-283202NA 830N/AOrganotin, Heavy
metal
Basic lead silicate53466-66-348003NA 417N/AInorganic-Lead,
Heavy metal
Lead7439-92-1NA 1342638N/AInorganic-Lead,
Heavy metal
Lead acetate301-04-248001NA 415N/AInorganic-Lead,
Heavy metal
Lead arsenate7784-40-913503353Herbicide,Inorganic-arsenic,
Insecticide,Inorganic-lead,
RodenticideHeavy metal
Lead arsenate, basic1327-31-713502354Herbicide,Inorganic-arsenic,
Insecticide,Inorganic-lead,
RodenticideHeavy metal
Lead metasilicateNA 938NA 1381106N/AInorganic-Lead,
Heavy metal
Lead monoxide10190-55-3NA 1231271N/AInorganic-Lead,
Heavy metal
Lead naphthenate61790-14-5480043296N/AInorganic-Lead,
Heavy metal
Litharge1317-36-848002NA 416N/AInorganic-Lead,
Heavy metal
Alkyl*-1-(2-aminoethyl)-2-NA 118846606NA 167MicrobiocideInorganic-Nickel,
imidazoline acetate-nickelImidazoline
sulfate complex
Maneb and nickel sulfate8005-46-7#####NA 158FungicideDithiocarbamate,
hexahydrate (014505 + 050505)Inorganic-Nickel
Nickel7440-02-0NA 121762N/AInorganic-Nickel
Nickel diethyl hexyl acidNA 928NA 533696N/AInorganic-Nickel
phosphate complex
Nickel sulfate (anhydrous)7786-81-450508NA 420FungicideInorganic-Nickel
Nickel sulfate hexahydrate10101-97-050505NA 419FungicideInorganic-Nickel
Fatty acid*-silver complex24927-67-172505NA 675Microbiocide,Inorganic-Silver,
*(100% C8)Fungicide,Heavy metal
Herbicide
Metallic silver7440-22-4725012125Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver acetate563-63-372507NA 676Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver carbonate534-16-772509NA 678Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver chloride7783-90-6725062324Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver copper zeolite130328-19-7#####NA 110MicrobiocideInorganic-Silver,
Heavy metal,
Inorganic-Copper
Silver fluoride7775-41-972502NA 674Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver iodide, colloidal7783-96-2NA 1241556Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver nitrate7761-88-8725032856Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide,
Plant Growth
Regulator
Silver orthophosphate7784-09-072510NA 679Microbiocide,Inorganic-Silver,
(Ag3PO4)Fungicide,Heavy metal
Herbicide
Silver oxide (Ag4O4)1301-96-8#####NA 111Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver oxide (Ag4O4)155645-89-9#####NA 111Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver sodium hydrogenNA 116672560NA 164MicrobiocideInorganic-Silver,
zirconium phosphateHeavy metal
(Ag0.18Na0.57H0.25Zr2(PO4)3)
Silver thiocyanate1701-93-568203NA 606Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Silver thiuronium acrylate co-53404-00-572701NA 681Microbiocide,Inorganic-Silver,
polymerFungicide,Heavy metal
Herbicide
Silver zeolite130328-18-6#####NA 125MicrobiocideInorganic-Silver,
Heavy metal
Silver zinc zeolite130328-20-0#####NA 111MicrobiocideInorganic-Silver,
Inorganic-Zinc,
Heavy metal
Silver, ionic14701-21-4NA 1695150Microbiocide,Inorganic-Silver,
Fungicide,Heavy metal
Herbicide
Sodium silver thiosulfateNA 1398NA 197NA 196HerbicideInorganic-Silver,
Heavy metal
2-Mercaptobenzothiazole, zinc155-04-4517051449Fungicide,Mercaptobenzothiazole,
saltMicrobiocideInorganic-Zinc
5-Chloro-2-53404-93-651709NA 427Microbiocide,Mercaptobenzothiazole,
mercaptobenzothiazole, zincFungicideInorganic-Zinc
salt
Boric acid(H4B6O11), zinc12447-61-9#####5094FungicideInorganic-Zinc
salt(1:2)
Calcium-zinc LN 193NA 653NA 1203871N/AInorganic-Zinc
(complex)
Chromated zinc chlorideNA 1026878011187Insecticide,Inorganic-
Herbicide,Chromium(VI),
MicrobiocideInorganic-Zinc,
Heavy metal
Copper-zinc chromate complex1344-74-721003163Fungicide,Inorganic-
WoodChromium(VI),
PreservativeInorganic-Zinc,
Heavy metal,
Inorganic-Copper
Copper-zinc sulfate complex55072-57-68102164FungicideInorganic-Zinc,
Inorganic-Copper
Copper-zinc sulfate complex,NA 959NA 3821751FungicideInorganic-Zinc,
monohydrateInorganic-Copper
Crag turf fungicide 53112001-20-621006NA 171FungicideInorganic-Cadmium,
(Cd—Cu—Ca—Zn-Chromate)Inorganic-
Chromium(VI),
Inorganic-Zinc,
Heavy metal
EDTA, disodium zinc salt14025-21-9NA 2743189N/AInorganic-Zinc
Lignin sulfonic acid, zinc saltNA 1014NA 1021768N/AInorganic-Zinc
Lignin sulfonic acid, zinc,NA 1030NA 1261771N/AInorganic-Zinc
manganese & iron salts
Mancozeb223310014504211FungicideDithiocarbamate,
Inorganic-Zinc
Metiram9006-42-214601493FungicideDithiocarbamate,
Inorganic-Zinc
o-Phenylphenol, alkyl* amine-82010-74-064107NA 533MicrobiocidePhenols, Inorganic-
zinc salt of *(100% C18)Zinc
Pentachlorophenol, zinc salt2917-32-063008NA 510WoodChlorinated Phenol,
Preservative,Inorganic-Zinc
Microbiocide,
Algaecide,
Fungicide
Polyoxin D zinc salt146659-78-1#####NA 129FungicideInorganic-Zinc
Propineb12071-83-9#####NA 155Fungicide,Dithiocarbamate,
MicrobiocideInorganic-Zinc
Silver zinc zeolite130328-20-0#####NA 111MicrobiocideInorganic-Silver,
Inorganic-Zinc,
Heavy metal
Zinc7440-66-6#####2310HerbicideInorganic-zinc
Zinc 2,4,5-trichlorophenate136-24-364221NA 546N/AChlorinated Phenol,
Inorganic-Zinc
Zinc 2-ethyl hexoate136-53-8412033509N/AInorganic-Zinc
Zinc 2-pyridinethiol-1-oxide13463-41-7880022128MicrobiocideInorganic-Zinc
Zinc 8-quinolinolate13978-85-324005NA 196Fungicide,Inorganic-Zinc
Microbiocide
Zinc abietate6798-76-1NA 1123506N/AInorganic-Zinc
Zinc arsenate13464-44-313301NA 125Herbicide,Inorganic-Arsenic,
Insecticide,Heavy metal,
RodenticideInorganic-Zinc
Zinc arsenite28837-97-013604NA 130Herbicide,Inorganic-Arsenic,
Insecticide,Inorganic-Zinc,
RodenticideHeavy metal
Zinc bacitracin1405-89-66309NA 87MicrobiocideInorganic-Zinc
Zinc carbonate3486-35-9NA 1023507N/AInorganic-Zinc
Zinc chloride7646-85-787801624MicrobiocideInorganic-Zinc
Zinc dehydroabietylammonium53404-92-54211NA 75Fungicide,Inorganic-Zinc
2-ethylhexanoateMicrobiocide
Zinc dodecyl benzene sulfonate12068-16-5NA 1123508Microbiocide,Soap, Inorganic-Zinc
Adjuvant,
Fungicide,
Insecticide
Zinc fluosilicate16871-71-9753071019InsecticideInorganic-Zinc
Zinc formate557-41-587802NA 838N/AInorganic-Zinc
Zinc hydroxide20427-58-1885013510N/AInorganic-Zinc
Zinc isodecanoate30304-30-441222NA 355N/AInorganic-Zinc
Zinc isononanoate5398-80-641212NA 353N/AInorganic-Zinc
Zinc isooctanoate84082-93-941205NA 351N/AInorganic-Zinc
Zinc mercury chromate22323-45-121004NA 170FungicideInorganic-Mercury,
Inorganic-
chromium(VI),
Inorganic-Zinc,
Heavy metal
Zinc naphthenate12001-85-3883011111WoodInorganic-Zinc
Preservative,
Insecticide,
Fungicide, Dog
and Cat
Repellent
Zinc neodecanoate27253-29-897502NA 853N/AInorganic-Zinc
Zinc oxide1314-13-288502666Fungicide,Inorganic-Zinc
Adjuvant
Zinc petroleum (C20-C30)68989-17-388503NA 841N/AInorganic-Zinc
sulfonate
Zinc phenol sulfonate127-82-289002NA 842N/AInorganic-Zinc
Zinc phosphide1314-84-788601626RodenticideInorganic-Zinc
Zinc resinate9010-69-977001NA 712N/AInorganic-Zinc
Zinc silicateNA 13188103NA 176MicrobiocideInorganic-Zinc
Zinc stearate557-05-1770023511N/AInorganic-Zinc
Zinc sulfate7733-02-089001667Microbiocide,Inorganic-Zinc
Herbicide
Zinc sulfate, anhydrous7733-02-0890011852Microbiocide,Inorganic-Zinc
Herbicide
Zinc sulfate, basic68813-94-589101NA 843N/AInorganic-Zinc
Zinc sulfate, monohydrate7446-19-7#####2995HerbicideInorganic-Zinc
Zinc trichlorophenate30143-22-764213NA 543MicrobiocideChlorinated Phenol,
Inorganic-Zinc
Zineb12122-67-714506627FungicideDithiocarbamate,
Inorganic-Zinc
Zineb-ethylene thiuramNA 1465NA 217NA 216FungicideDithiocarbamate,
disulfide adductInorganic-Zinc
Ziram137-30-434805629Fungicide,Dithiocarbamate,
Microbiocide,Inorganic-Zinc
Dog and Cat
Repellent
Ziram, cyclohexylamine16509-79-8348061328Dog and CatDithiocarbamate,
complexRepellent,Inorganic-Zinc
Fungicide
1-butoxy ethoxy-2-propanol124-16-3NA 1133074N/AAlcohol/Ether
1-butoxy-2-propanol5131-86-8NA 4673075SolventAlcohol/Ether
1-decanol112-30-1790381791Plant GrowthAlcohol/Ether
Regulator
1-Heptadecanol1454-85-9#####NA 150N/AAlcohol/Ether
1-heptanol111-70-6NA 2053222N/AAlcohol/Ether
1-hexanol111-27-3790473229N/AAlcohol/Ether
1-Octanol111-87-579037NA 733Plant GrowthAlcohol/Ether
Regulator,
Herbicide
2,6,8-trimethyl-4-nonanol123-17-1NA 1443303AdjuvantAlcohol/Ether
2-(2-Butoxyethoxy)ethanol112-34-511502NA 117SolventAlcohol/Ether,
Glycol Ether
2-butoxyethanol111-76-21150189Fungicide,Alcohol/Ether
Microbiocide,
Solvent
2-ethoxyethanol110-80-5NA 1042554Fungicide,Alcohol/Ether
Microbiocide
2-Ethyl-1-butanol97-95-0#####NA 148N/AAlcohol/Ether
2-ethyl-1-hexanol10-47-6NA 2512560N/AAlcohol/Ether
2-Ethyl-1-hexanol104-76-779098NA 767SolventAlcohol/Ether
2-Phenylcyclohexanol1444-64-065002NA 550N/AAlcohol/Ether
2-Phenylethanol60-12-81503NA 62N/AAlcohol/Ether
3,3,5-trimethyl cyclohexanol116-02-9NA 9823493N/AAlcohol/Ether
3-phenoxybenzyl alcohol13826-35-2NA 6512771N/AAlcohol/Ether
4-Methyl-2-pentanol108-11-2#####NA 157N/AAlcohol/Ether
Alcohols, C4-C12, normalNA 392NA 7132067Solvent,Alcohol/Ether
Microbiocide
Alcohols, C6-1268603-15-6790295072Microbiocide,Alcohol/Ether
Solvent
Alcohols, C8-1085566-12-7790595073Microbiocide,Alcohol/Ether
Solvent
Alkanols (ave. C6), mixedNA 394NA 7161536AdjuvantAlcohol/Ether
Alkylaryl polyether alcoholNA 657NA 121878AdjuvantAlcohol/Ether
Allyl alcohol107-18-6684013023HerbicideAlcohol/Ether
Benzyl alcohol100-51-69502915Insecticide,Alcohol/Ether
Fungicide
Butyl alcohol78-92-215021482SolventAlcohol/Ether
Cetyl alcohol36653-82-415082449N/AAlcohol/Ether
Cinnamyl alcohol104-54-140512NA 343InsecticideAlcohol/Ether
Cyclobutaneethanol, 1-methyl-30820-22-5#####NA 922N/AAlcohol/Ether
2-(1-methylethenyl)-,cis-
Cyclohexanol108-93-0259043121SolventAlcohol/Ether
Denatured ethanolNA 1033NA 1292102SolventAlcohol/Ether
Dimethyl ether115-10-6NA 1322517SolventAlcohol/Ether
Ethyl alcohol64-17-515018Microbiocide,Alcohol/Ether
Solvent,
Adjuvant,
Molluscicide
Ethylene oxide75-21-842301277FumigantAlcohol/Ether
Fatty alcohols (100% C4-C10)NA 126NA 2413654AdjuvantAlcohol/Ether
Fatty alcohols (55.10% C10,NA 126579089NA 173Plant GrowthAlcohol/Ether
42.88% C8, 1.01% C6, 1.01%Regulator,
C12)Adjuvant
Fatty alcohols (65% C12, 26%67762-41-879056NA 744AdjuvantAlcohol/Ether
C14, 8% C16, 1% C10)
Hydrocinnamyl alcohol122-97-440511NA 342N/AAlcohol/Ether
i-Nonyl alcohol3452-97-9#####NA 153N/AAlcohol/Ether
Isobutyl alcohol78-83-115072622SolventAlcohol/Ether
Isodecyl alcohol25339-17-7NA 1683242SolventAlcohol/Ether
Isopropyl alcohol67-63-047501342Microbiocide,Alcohol/Ether
Solvent
Isostearyl alcohol27458-93-1NA 1562627AdjuvantAlcohol/Ether
Lauryl alcohol112-53-815092343Pheromone,Pheromone,
AdjuvantAlcohol/Ether
Methanol67-56-1538011018Solvent,Alcohol/Ether
Adjuvant,
Microbiocide
Methoxypropanol107-98-2NA 902675SolventAlcohol/Ether
Myristyl alcohol112-72-115102344Pheromone,Alcohol/Ether
Fragrance
n-Butyl alcohol71-36-3NA 4683077SolventAlcohol/Ether
n-Decyl alcohol112-30-1790383124Plant GrowthAlcohol/Ether
Regulator
n-Propoxy propanol30136-13-1NA 7982837SolventAlcohol/Ether
n-Propyl alcohol71-23-8475021603SolventAlcohol/Ether
Oleyl alcohol143-28-2NA 93313AdjuvantAlcohol/Ether
Propargyl alcohol107-19-768702NA 609BreakdownAlcohol/Ether
product
Propylene oxide75-56-942501508FumigantAlcohol/Ether
sec-Butanol75-65-01505NA 64SolventAlcohol/Ether
Sec-butyl alcohol78-92-215023078SolventAlcohol/Ether
Stearyl alcohol112-92-5NA 1102892AdjuvantAlcohol/Ether
Tetrahydro furfuryl alcohol97-99-4NA 9453471SolventAlcohol/Ether
(2-150-39-039108NA 330AdjuvantChelating agent
Hydroxyethyl)ethylenediamine
triacetic acid
Dimethamine EDTANA 167NA 3193159AdjuvantChelating agent
EDTA60-00-4391011702AdjuvantChelating agent
EDTA, ammonium salt7379-26-239117889AdjuvantChelating agent
EDTA, diethanolamine salt68133-37-9NA 2733187AdjuvantChelating agent
EDTA, disodium salt139-33-3391152101Herbicide,Chelating agent
Adjuvant
EDTA, disodium salt139-33-339115954Herbicide,Chelating agent
Adjuvant
EDTA, iron chelateNA 890NA 1703240HerbicideChelating agent
EDTA, monoethanolamine salt7379-26-2391172013AdjuvantChelating agent
EDTA, monopotassium salt7379-27-339111NA 331AdjuvantChelating agent
EDTA, potassium saltNA 891NA 1703350AdjuvantChelating agent
EDTA, sodium salt17421-79-3391031757AdjuvantChelating agent
EDTA, tetrapotassium salt5964-35-2391181054AdjuvantChelating agent
EDTA, tetrasodium salt64-02-839107759AdjuvantChelating agent
EDTA, trisodium salt150-38-939110953AdjuvantChelating agent
Ethanolamine63517-71-539116NA 334Adjuvant,Chelating agent
ethylenediaminetetraacetateFungicide
N-(2-hydroxyethyl) ethylene139-89-939109911Microbiocide,Chelating agent
diamine triacetic acid, trisodiumAdjuvant
salt
Nitrilotriacetic acid139-13-9NA 228NA 228AdjuvantChelating agent
Nitrilotriacetic acid, sodium10042-84-9#####NA 121AdjuvantChelating agent
salt
Sodium N-(2-53404-54-939121NA 335AdjuvantChelating agent
hydroxyethyl)ethylenediaminetriacetate
Tetra(monoethanolamine)53404-52-739112NA 332Adjuvant,Chelating agent
ethylenediaminetetraacetateAdjuvant
Triethylamine EDTANA 790NA 1463486AdjuvantChelating agent
Triethylamine nitrilo triacetateNA 537NA 9783487AdjuvantChelating agent
Tripotassium17572-97-3391131177AdjuvantChelating agent
ethylenediaminetetraacetate
Trisodium nitrilo triacetate5064-31-3391061121AdjuvantChelating agent
2,4,5-T, butoxyethanol ester2545-59-782053819HerbicideChlorophenoxy acid
or ester, Glycol Ether
2,4-D, butoxyethanol ester1929-73-330053802HerbicideChlorophenoxy acid
or ester, Glycol Ether
2-(2-Butoxyethoxy)ethanol112-34-511502NA 117SolventAlcohol/Ether,
Glycol Ether
4-(2,4-DB), butoxyethanol32357-46-330853837HerbicideChlorophenoxy acid
esteror ester, Glycol Ether
Alkylaryl polyglycol etherNA 319NA 5991264AdjuvantPolyalkyloxy
Compound, Glycol
Ether
Cinoxate104-28-976604NA 706N/AGlycol Ether
Dichlorprop, butoxyethanol53404-31-231453923Plant GrowthChlorophenoxy acid
esterRegulator,or ester, Glycol Ether
Herbicide
Diethylene glycol monoethyl111-90-0115042505Adjuvant,Glycol Ether
etherSolvent
Diethylene glycol monomethyl111-77-3422042506Adjuvant,Glycol Ether
etherSolvent
Ethoxyethoxyethyl 2,4-53404-36-730058NA 245HerbicideChlorophenoxy acid
dichlorophenoxyacetateor ester, Glycol Ether
Ethyl amino benzoate111-15-9NA 2603192N/AGlycol Ether
Ethylene glycol, mono-butyl111-76-2115011880Solvent,Glycol Ether
etherAdjuvant
Haloxyfop-etotyl (unstated87237-48-7NA 200NA 199HerbicideAryloxyphenoxy
stereochemistry)propionic acid,
Glycol Ether
MCPA, butoxyethanol ester19480-43-430553785HerbicideChlorophenoxy acid
or ester, Glycol Ether
Silvex, butoxyethanol ester19398-13-182553828HerbicideChlorophenoxy acid
or ester, Glycol Ether
Triclopyr, butoxyethyl ester64700-56-7#####2170HerbicideChloropyridinyl,
Glycol Ether
(Decyl oxy) poly (oxy9038-29-3NA 1173636AdjuvantPolyalkyloxy
ethylene) poly (oxy propylene)Compound
(Octyl oxy) poly (oxyethylene)61827-84-7NA 1023707AdjuvantPolyalkyloxy
poly (oxypropylene)Compound
2,6,8-trimethyl-4-nonyloxyNA 1162NA 1755599AdjuvantPolyalkyloxy
polyethylene oxyethanolCompound
4-nonyl phenoxy polyNA 805NA 1493698Soap/Surfactant,Polyalkyloxy
(ethylene oxy) ethyl phosphate,AdjuvantCompound
magnesium salt
a-(p-nonylphenyl)-omega-NA 27NA 402066MicrobiocidePolyalkyloxy
hydroxypoly (oxyethylene)Compound
with an average of 4.2 moles of
ethylene oxide.the nonly group
is a propylene
a-(p-nonylphenyl)-omega-NA 28NA 412052MicrobiocidePolyalkyloxy
hydroxypoly (oxyethylene)Compound
with an averageof 9-10 moles
of ethylene oxide
Alkenoic acid poly oxyalkyleneNA 396NA 7182364AdjuvantPolyalkyloxy
ether & alkyl poly oxyalkyleneCompound
ether
Alkoxy poly (ethyleneoxy)NA 286NA 5551390Adjuvant,Polyalkyloxy
ethyl phosphateSoap/SurfactantCompound
Alkyl (100% C10-C13) oxyNA 288NA 5603575Adjuvant,Polyalkyloxy
poly (ethylene oxy) ethylSoap/SurfactantCompound
phosphate, mono-
Alkyl (100% C10-C14) oxy68585-36-4NA 5793574Adjuvant,Polyalkyloxy
poly (ethylene oxy) ethylSoap/SurfactantCompound
phosphate
Alkyl (100% C11-C15)68131-40-8790843572Insecticide,Polyalkyloxy
phenoxypoly (ethylene oxy)Fungicide,Compound
ethanolAvicide,
Adjuvant
Alkyl (C8,C10) polyglycoside68515-73-1NA 1544015AdjuvantPolyalkyloxy
Compound
Alkyl and alkylaryl polyNA 398NA 7201706AdjuvantPolyalkyloxy
(oxyethylene) glycols, mixedCompound
Alkyl aryl alkoxylateNA 314NA 5942366AdjuvantPolyalkyloxy
Compound
Alkyl aryl polyoxyalkane etherNA 323NA 6032370AdjuvantPolyalkyloxy
and free fatty acidsCompound
Alkyl oxy poly (ethyleneoxy)NA 679NA 1251715Adjuvant,Polyalkyloxy
ethyl phosphateSoap/SurfactantCompound
Alkyl oxy polyethoxy ethanolNA 306NA 5782048AdjuvantPolyalkyloxy
Compound
Alkyl oxy-polyoxyethylene andNA 289NA 5612136AdjuvantPolyalkyloxy
alkyl phenyloxy-Compound
polyoxyethylene
Alkyl phenoxypoly (ethoxy)NA 291NA 5631173AdjuvantPolyalkyloxy
ethanolCompound
Alkyl phenyl poly (ethoxy)NA 294NA 5661064AdjuvantPolyalkyloxy
ethanolCompound
Alkyl polyethylene glycol etherNA 668NA 1231376Adjuvant,Polyalkyloxy
Soap/SurfactantCompound
Alkyl polyoxy alkylene etherNA 295NA 5672123AdjuvantPolyalkyloxy
Compound
Alkyl polyoxy ethylene ether,NA 592NA 1072014AdjuvantPolyalkyloxy
diphosphoric acid esterCompound
Alkyl polyoxy ethylene ether,NA 296NA 5682377AdjuvantPolyalkyloxy
free fatty acidsCompound
Alkyl polyoxy ethylene ether,NA 694NA 1272015AdjuvantPolyalkyloxy
monophosphoric acid esterCompound
Alkyl polyoxy ethylene ethers,NA 297NA 5692158AdjuvantPolyalkyloxy
polymerized resins and fattyCompound
acids
Alkyl polyoxy ethylene glycolsNA 285NA 5542051AdjuvantPolyalkyloxy
Compound
Alkylaryl hydroxypolyNA 316NA 5962037AdjuvantPolyalkyloxy
(oxyethylene) ethanolCompound
Alkylaryl poly(oxyethylene)NA 315NA 595748AdjuvantPolyalkyloxy
glycolCompound
Alkylaryl polyalkoxylatedNA 705NA 1292174AdjuvantPolyalkyloxy
alcoholsCompound
Alkylaryl polyethoxy ethanolNA 714NA 1302368Adjuvant,Polyalkyloxy
phosphateSoap/SurfactantCompound
Alkylaryl polyethoxyethanolNA 912NA 1745323AdjuvantPolyalkyloxy
sulfatesCompound
Alkylaryl polyethylene glycolNA 318NA 5982198Adjuvant,Polyalkyloxy
etherSoap/SurfactantCompound
Alkylaryl polyglycol esterNA 1470NA 218NA 218AdjuvantPolyalkyloxy
Compound
Alkylaryl polyglycol etherNA 319NA 5991264AdjuvantPolyalkyloxy
Compound, Glycol
Ether
Alkylaryl polyoxy glycolNA 322NA 6022369AdjuvantPolyalkyloxy
Compound
Alkylaryl polyoxyethyleneNA 320NA 600881AdjuvantPolyalkyloxy
etherCompound
Alkylaryl polyoxyethyleneNA 321NA 6012024Adjuvant,Polyalkyloxy
glycol phosphate esterSoap/SurfactantCompound
Alkylaryl poyloxyethyleneNA 671NA 1241507AdjuvantPolyalkyloxy
ethanolCompound
Alkylpoly glycol etherNA 292NA 5641172AdjuvantPolyalkyloxy
Compound
Allyl oxy poly ethylene glycolNA 279NA 5452376N/APolyalkyloxy
monoallyl acetateCompound
Alpha (para-tert-butyl phenyl)-NA 235NA 4631605AdjuvantPolyalkyloxy
omega-hydroxypolyCompound
(oxyethylene)-
Alpha (para-tert-butylphenyl)-NA 234NA 4621786AdjuvantPolyalkyloxy
omega-hydroxypolyCompound
(oxyethylene)
Alpha-(omega-sec-butylNA 231NA 4521885AdjuvantPolyalkyloxy
phenylpoly (oxypropylene))-Compound
omega-hydroxypoly
Alpha-(p-(1,1,3,3-tetramethylNA 609NA 1111932AdjuvantPolyalkyloxy
butyl) phenyl)-omega-hydroxypolyCompound
Alpha-(p-nonylphenyl)-omega-NA 745NA 1352710AdjuvantPolyalkyloxy
hydroxypoly (oxypropylene)Compound
Alpha-(para-nonyl phenyl)-NA 18NA 311649AdjuvantPolyalkyloxy
omega-hydroxypolyCompound
(oxyethylene)
Alpha-alkyl (43% C10,NA 684NA 1261834MicrobiocidePolyalkyloxy
30% C14, 12% C12, 10% C16,Compound
5% C18) poly (oxyethylene)
poly (oxypropylene) - I2
complex
Alpha-alkyl (C10-C12)-omega-NA 307NA 5822077AdjuvantPolyalkyloxy
hydroxypoly (oxyethylene)Compound
Alpha-alkyl (C10-C18)-NA 301NA 5731700AdjuvantPolyalkyloxy
omega-hydroxypolyCompound
(oxyethylene) sulfate
150 solvent neutral BP 901NA 747NA 1362724InsecticidePetroleum derivative
base oil
Alkylated aromatic petroleum68919-17-554001NA 451Insecticide,Petroleum derivative
oilAdjuvant
Amoco 6342NA 715NA 1312384N/APetroleum derivative
Anthracene oil120-12-7NA 185NA 184Insecticide,Petroleum derivative
Herbicide,
Rodenticide
Aromatic 100NA 269NA 5242394Insecticide,Petroleum derivative
Solvent
Aromatic 150NA 716NA 1312395Insecticide,Petroleum derivative
Solvent
Aromatic 20064742-94-566022396Insecticide,Petroleum derivative
Solvent
Asphalt solids8052-42-4220011140Pruning AidPetroleum derivative
Bitumen8052-42-422002NA 171N/APetroleum derivative
Candle waxNA 227NA 4402443N/APetroleum derivative
Chevron 100 neutral oil68602-80-266012456InsecticidePetroleum derivative
Chevron base oil “C”NA 224NA 4312455InsecticidePetroleum derivative
Chevron solvent 425NA 722NA 1322457SolventPetroleum derivative
Coal tar distillate boiling65996-91-061015042Insecticide,Petroleum derivative
between 270-300 deg C.Herbicide
Coal tar hydrocarbons8007-45-2220031719WoodPetroleum derivative
Preservative
Coal tar neutral oils and coal65996-82-925001144Insecticide,Petroleum derivative
tar acid combinationsHerbicide
Coal tar phenols1319-77-3221011720N/APetroleum derivative,
Phenols
Coal tar pitch >35165996-93-2#####NA 106InsecticidePetroleum derivative
deg. C.(AWPI)
Conoco LPANA 195NA 3862478N/APetroleum derivative
Creosote8001-58-925004171WoodPetroleum derivative
Preservative
Creosote oil (note: derived61789-28-425003NA 203WoodPetroleum derivative
from any source)Preservative,
Fungicide
Cumene98-82-8NA 1053116N/APetroleum derivative
Cyclohexane110-82-7259012087SolventPetroleum derivative
Diesel fuel no. 268476-34-6635143923Insecticide,Petroleum derivative
Adjuvant
Ethyl benzene100-41-4NA 1423197N/APetroleum derivative
Ethylene74-85-141901270Plant GrowthPetroleum derivative
Regulator
Fuel oil #170892-10-363511NA 520N/APetroleum derivative
Fuel oil #268476-30-263505NA 517N/APetroleum derivative
Fuel oil #468476-31-363512NA 521N/APetroleum derivative
Fuel oil #668553-00-463513NA 522N/APetroleum derivative
GasolineNA 945NA 2211899N/APetroleum derivative
Heavy oil (coal) 301-350 deg. C.90640-86-1#####NA 106N/APetroleum derivative
(AWPI)
Hydrotreated paraffinic solventNA 91NA 1822601SolventPetroleum derivative
Isobutane75-28-5971012621PropellantPetroleum derivative
Isoparaffin, C11-C12NA 85NA 1632623N/APetroleum derivative
Isoparaffin, C12-C14NA 86NA 1642624N/APetroleum derivative
Isoparaffinic hydrocarbons64771-72-8#####1641N/APetroleum derivative
Isopentane78-78-4NA 1653244SolventPetroleum derivative
Jet fuel94114-58-663515NA 523Insecticide,Petroleum derivative
Solvent
Kerosene8008-20-6635012071InsecticidePetroleum derivative
KM spray oilNA 78NA 1502631N/APetroleum derivative
Ligroin8032-32-4635062642SolventPetroleum derivative
Low molecular weight64642-47-8NA 1735252InsecticidePetroleum derivative
paraffinic oil
MCIAL code 40164742-55-8635032045Insecticide,Petroleum derivative
Adjuvant
Mineral oil8012-95-163502401Insecticide,Petroleum derivative
Adjuvant
Mineral oil, petroleum64741-89-5635033846Herbicide,Petroleum derivative
distillates, solvent refined lightPlant Growth
Regulator,
Insecticide,
Adjuvant
Mineral oil, petroleum extract,64724-04-7NA 1713847Insecticide,Petroleum derivative
heavy paraffinic distillateAdjuvant
Mineral seal oilNA 930NA 672687Insecticide,Petroleum derivative
Adjuvant
Mineral spirits8032-32-4635062688Insecticide,Petroleum derivative
Solvent,
Fungicide
n-Hexane110-54-3NA 1033227SolventPetroleum derivative
Naphtha, heavy aromatic64742-94-566021717Insecticide,Petroleum derivative
Solvent
Orchex 796 oilNA 899NA 1725179Insecticide,Petroleum derivative
Adjuvant
Paraffin wax8002-74-2NA 1071214RodenticidePetroleum derivative
Paraffin waxes (petroleum)64742-51-4NA 6943545N/APetroleum derivative
hydrotreated
Paraffin waxes and61788-76-9NA 6933721N/APetroleum derivative
hydrocarbon waxes,
chlorinated
Pentane109-66-098001469SolventPetroleum derivative
Petroleum derivative resin64742-16-1114011411N/APetroleum derivative
Petroleum distillates222737863503763InsecticidePetroleum derivative
Petroleum distillates, aliphatic2227378635032768Insecticide,Petroleum derivative
Adjuvant,
Solvent
Petroleum distillates, aromatic68477-31-665011814Solvent,Petroleum derivative
Herbicide,
Insecticide
Petroleum distillates, refined64741-51-1NA 6542106InsecticidePetroleum derivative
Petroleum hydrocarbons8012-95-163502473Insecticide,Petroleum derivative
Solvent
Petroleum jelly2229873#####1443InsectPetroleum derivative
Repellent,
Adjuvant
Petroleum naphthenic oilsNA 990NA 6552107Insecticide,Petroleum derivative
Adjuvant
Petroleum oil, unclassified68815-10-1NA 121765Insecticide,Petroleum derivative
Herbicide,
Fungicide,
Adjuvant
Petroleum sulfonates61789-85-3#####766N/APetroleum derivative
Petroleum, unrefined2227378635031730Insecticide,Petroleum derivative
Adjuvant
Polybutenes9003-29-6114021040RodenticidePetroleum derivative
Polyisobutylene9003-27-4114031561RodenticidePetroleum derivative
Propane74-98-6NA 1092832PropellantPetroleum derivative
Propylene1150-70-1NA 8002838N/APetroleum derivative
Solvent naphtha (coal), 150-20065996-79-4#####NA 106SolventPetroleum derivative
deg. C.
Solvent naphtha (petroleum),64742-95-6868033804SolventPetroleum derivative
light aromatic
Summer oilNA 1468NA 218NA 218Insecticide,Petroleum derivative
Adjuvant
Sun superior spray oil 7NNA 769NA 1392902Insecticide,Petroleum derivative
Adjuvant
Synthetic beeswaxNA 509NA 9202910N/APetroleum derivative
TarNA 131222004NA 176WoodPetroleum derivative
Preservative
Tar acid oilNA 1041NA 1392914InsecticidePetroleum derivative
Toluene108-88-3806011281SolventPetroleum derivative
Turpentine8006-64-284501605Insecticide,Petroleum derivative
Adjuvant
White mineral oil8042-47-563510NA 519Insecticide,Petroleum derivative
Adjuvant
Winter oilNA 1472NA 219NA 218AdjuvantPetroleum derivative
Xylene1330-20-786802622Solvent,Petroleum derivative
Microbiocide
Xylene range aromatic solvent68920-06-9NA 102862Solvent,Petroleum derivative
Insecticide
3-(3-hydroxypropyl)-heptamethylNA 90NA 1782610AdjuvantSilicone
trisiloxane, ethoxylated,
acetate
Compounded siliconeNA 703NA 1292124AdjuvantSilicone
Dimethyl poly sloxane63148-62-9NA 1041861Insecticide,Silicone
Adjuvant
Dimethyl silicone fluidNA 696NA 1282028AdjuvantSilicone
emulsion
Dow Corning antifoam Y-30NA 146NA 2802539AdjuvantSilicone
emulsion
Dow Corning DB-110A-NA 577NA 1042540AdjuvantSilicone
antifoam emulsion
Heptamethyltrisiloxane67674-67-3NA 1534009AdjuvantSilicone
ethoxylated (8 EO)
Methyl silicone resins9016-00-6NA 773689AdjuvantSilicone
Methylated silica67762-90-7NA 1735292N/ASilicone
Organo/modified polysiloxane37281-78-0NA 1533997AdjuvantSilicone
Organosilicone, polyoxyalkylene67762-85-0NA 1735231AdjuvantSilicone
ether copolymer
Polyalkene oxide modified27306-78-1NA 1463520AdjuvantSilicone
heptamethyl trisiloxane
Polyalkyleneoxide modifiedNA 904NA 1725203AdjuvantSilicone
polydimethyl-siloxane
Polyether modifiedNA 906NA 1725223AdjuvantSilicone
polysiloxane
PolysiloxaneNA 1337NA 1805718AdjuvantSilicone
SiliconeNA 815NA 1503796AdjuvantSilicone
Silicone defoamerNA 462NA 8261917AdjuvantSilicone
Silicone mold release agent SMNA 463NA 8272854N/ASilicone
2140
Silicone-polyether copolymer27306-78-1NA 1513841AdjuvantSilicone
Trimethyl siloxy stearateNA 541NA 9872965N/ASilicone
1,1,2,3-tetramethyl butylamineNA 1010NA 9483472Microbiocide,Soap
dodecyl benzene sulfonateAdjuvant,
Fungicide,
Insecticide
1,3-propane diamine dodecylNA 1021NA 1153369Microbiocide,Soap
benzene sulfonateAdjuvant,
Fungicide,
Insecticide
2,2-oxybis (4-dodecyl benzeneNA 1161NA 1751741Microbiocide,Soap
sulfonate)Adjuvant,
Fungicide,
Insecticide
2-((2-amino ethyl) amino)68084-55-9NA 5383034Microbiocide,Soap
ethanol dodecyl benzeneAdjuvant,
sulfonateFungicide,
Insecticide
Alkanolamide surfactantsNA 911NA 1745322Soap/Surfactant,Soap
Adjuvant
Alkyl* sodium benzene68411-30-3#####NA 126Microbiocide,Soap
sulfonate *(56% C11, 33% C12,Adjuvant,
7% C10, 4% C13)Fungicide,
Insecticide
Ammonium lauryl sulfate2235-54-3790281017Adjuvant,Soap
Insecticide,
Microbiocide,
Fungicide
Ammonium oleate544-60-5317031230Adjuvant,Soap
Insecticide
Ammonium tall oil fatty acid544-60-531703995Adjuvant,Soap
soapInsecticide
Benzene, 1,1′-oxybis-119345-04-9NA 1473561Microbiocide,Soap
tetrapropylene derivatives,Adjuvant,
sulfonated, sodiumFungicide,
Insecticide
Butylamine dodecyl benzene12068-09-6NA 4693079Microbiocide,Soap
sulfonateAdjuvant,
Fungicide,
Insecticide
Coconut oil soapNA 199NA 3912088Adjuvant,Soap
Insecticide,
Soap/Surfactant
DEA-dodecyl benzene26545-53-9790153123Microbiocide,Soap
sulfonateAdjuvant,
Fungicide,
Insecticide
Diethylamine salt of coconutNA 210NA 4021066Adjuvant,Soap
fatty acidSoap/Surfactant
Diisopropylamine dodecyl29061-61-8NA 3273156Microbiocide,Soap
benzene sulfonateAdjuvant,
Fungicide,
Insecticide
Dimethylalmine propylamineNA 953NA 3183162Microbiocide,Soap
tridecyl benzene sulfonateAdjuvant,
Fungicide,
Insecticide
Dimethylamine dodecylNA 954NA 3243161Microbiocide,Soap
benzene sulfonateAdjuvant,
Fungicide,
Insecticide
Disodium 2,2′-oxybis(4-5136-51-6790033175Microbiocide,Soap
dodecylbenzene)sulfonateAdjuvant,
Fungicide,
Insecticide
Disodium 4-dodecyl-2,4′-7575-62-4790023172Microbiocide,Soap
oxydibenzene sulfonateAdjuvant,
Fungicide,
Insecticide
Dodecyl alkyl sulfonateNA 284NA 5531599AdjuvantSoap
Dodecylbenzene sulfonic acid27176-87-098002941Adjuvant,Soap
Microbiocide,
Insecticide
Ethylene diamine dodecyl12068-06-3NA 2573200Microbiocide,Soap
benzene sulfonateAdjuvant,
Fungicide,
Insecticide
Fatty acid estersNA 1358NA 193NA 192Plant GrowthSoap
Regulator,
Insecticide,
Adjuvant
Free fatty acids and/or amine84776-33-0318011198Herbicide, DeerSoap
saltsRepellent,
Fungicide,
Insecticide
Hydrogenated wax, neutralNA 93NA 1871368Adjuvant,Soap
wax and alkali soaps of fattyInsecticide
acids
Isopropylamine26264-05-1790303247Microbiocide,Soap
dodecylbenzene sulfonateAdjuvant,
Fungicide,
Insecticide
Lauryl sulfate saltsNA 937NA 1372637Adjuvant,Soap
Insecticide,
Microbiocide,
Fungicide
Linear alkyl sulfonate,NA 283NA 5521836AdjuvantSoap
potassium salt
Magnesium lauryl sulfate435950790171718Adjuvant,Soap
Insecticide,
Microbiocide,
Fungicide
Mannitan coconut oil ester26545-55-0NA 1063680Adjuvant,Soap
Soap/Surfactant
Monoethanolamine dodecyl26545-53-9790151890Microbiocide,Soap
benzene sulfonateAdjuvant,
Fungicide,
Insecticide
N,N-dimethyl-1,3-propaneNA 950NA 3053168Microbiocide,Soap
diamine dodecyl benzeneAdjuvant,
sulfonateFungicide,
Insecticide
Naphthenic soap61790-13-4#####1806Adjuvant,Soap
Insecticide
Oleic acid, methyl ester112-62-9NA 52266AdjuvantSoap
Oleic acid, potassium salt143-18-079095865AdjuvantSoap
Oleic and linoleic acid, mixedNA 4NA 61807AdjuvantSoap
potassium salts
Organic phosphate esterNA 1NA 12725Soap/Surfactant,Soap
surfactantAdjuvant
Para-alkyl (C9-C13) benzene25155-30-0790101739Microbiocide,Soap
sulfonic acid, sodium saltAdjuvant,
Fungicide,
Insecticide
Phenyl 2-trimethylammonium22232-15-1#####NA 125Microbiocide,Soap
ethanesulfonate methyl sulfateAdjuvant,
Fungicide,
Insecticide
Potash fish soap68154-69-879040496Adjuvant,Soap
Insecticide
Potash soap61790-44-1#####1596Herbicide,Soap
Insecticide,
Adjuvant
Potassium alkyl benzene27177-77-179008994Microbiocide,Soap
sulfonatesAdjuvant,
Fungicide,
Insecticide
Potassium dodecylbenzene27177-77-1790081027Microbiocide,Soap
sulfonateAdjuvant,
Fungicide,
Insecticide
Potassium laurate10124-65-979021901Adjuvant,Soap
Insecticide,
Microbiocide,
Fungicide,
Soap/Surfactant
Potassium laurate and myristateNA 999NA 7802825Adjuvant,Soap
soapsInsecticide,
Microbiocide,
Fungicide
Potassium laurate, other relatedNA 1125NA 16690901Adjuvant,Soap
Insecticide,
Microbiocide,
Fungicide
Potassium lauryl sulfate4706-78-9NA 7813353AdjuvantSoap
Potassium myristate13429-27-179022902AdjuvantSoap
Potassium soap of coconut10124-65-979021903Adjuvant,Soap
fatty acidInsecticide,
Microbiocide,
Fungicide,
Soap/Surfactant
Potassium soap of tall oil fatty10124-65-9790211409Adjuvant,Soap
acidInsecticide,
Fungicide,
Microbiocide
Potassium stearate593-29-3NA 7843361AdjuvantSoap
Shampoo baseNA 460NA 8223795AdjuvantSoap
Soap68952-95-479009772Microbiocide,Soap
Insecticide,
Deer Repellent
Sodium alkyl* benzene26856-61-179087NA 760Microbiocide,Soap
sulfonate *(100% C9)Adjuvant,
Fungicide,
Insecticide
Sodium benzene sulfonate515-42-4NA 109974Microbiocide,Soap
Adjuvant,
Fungicide,
Insecticide
Sodium decyl benzene1322-98-1790883394Microbiocide,Soap
sulfonateAdjuvant,
Fungicide,
Insecticide
Sodium di (1-alkenyl) phenoxy39354-74-0790601373AdjuvantSoap
benzene disulfonate
Sodium dodecylbenzene25155-30-079010774Microbiocide,Soap
sulfonateAdjuvant,
Fungicide,
Insecticide
Sodium laurate629-25-479026NA 732Adjuvant,Soap
Insecticide,
Microbiocide,
Fungicide
Sodium lauryl ether diglycolNA 1471NA 219NA 218AdjuvantSoap
sulfate
Sodium lauryl ether sulfate9004-82-4790543799Adjuvant,Soap
Insecticide,
Microbiocide,
Fungicide,
Soap/Surfactant
Sodium lauryl sulfate151-21-379011907Adjuvant,Soap
Insecticide,
Microbiocide,
Fungicide
Sodium methylundecyl27987-00-479053NA 742Microbiocide,Soap
benzenesulfonateAdjuvant,
Fungicide,
Insecticide
Sodium mono (1-alkenyl)39354-74-0790601372AdjuvantSoap
phenoxy benzene disulfonate
Sodium n-decyl sulfate142-87-079077NA 754AdjuvantSoap
Sodium N-methyl-N-oleylNA 1004NA 8543419Adjuvant,Soap
laurateInsecticide,
Microbiocide,
Fungicide
Sodium nonanoyloxybenzene91129-43-8890535137Microbiocide,Soap
sulfonateAdjuvant,
Fungicide,
Insecticide
Sodium octylbenzene sulfonate28675-11-879057NA 745Microbiocide,Soap
Adjuvant,
Fungicide,
Insecticide
Sodium tallow soapNA 473NA 8703802Adjuvant,Soap
Insecticide
Sodium tetradecyl sulfate1191-50-0NA 1103446AdjuvantSoap
Sodium tridecylbenzene26248-24-879072NA 752Microbiocide,Soap
sulfonateAdjuvant,
Fungicide,
Insecticide
Sodium triisopropyl1323-19-9NA 8723448Insecticide,Soap
naphthalene sulfonateFungicide,
Microbiocide,
Adjuvant
Sodium triphenyl benzeneNA 1006NA 8733449Microbiocide,Soap
sulfonateAdjuvant,
Fungicide,
Insecticide
Sodium xylene sulfonate1300-72-779019909AdjuvantSoap
Sodium-1-octane sulfonate5324-84-5NA 8593886AdjuvantSoap
Soybean fatty acids, tert amineNA 480NA 8841308AdjuvantSoap
salt
Strontium dodecyl benzene12068-15-4NA 9063456Microbiocide,Soap
sulfonateAdjuvant,
Fungicide,
Insecticide
Sulfonated petroleum soap61789-62-679012NA 729Adjuvant,Soap
Insecticide
Sulfuric acid, monododecyl151-21-3790112901Adjuvant,Soap
ester sodium saltInsecticide,
Microbiocide,
Fungicide
Surfactant blendNA 1515NA 223NA 222Soap/Surfactant,Soap
Adjuvant
Surfactant mixtureNA 1516NA 223NA 223Soap/Surfactant,Soap
Adjuvant
Tallow soapNA 607NA 1101499Adjuvant,Soap
Insecticide
Triethanolamine27323-41-779020984Microbiocide,Soap
dodecylbenzene sulfonateAdjuvant,
Fungicide,
Insecticide
Zinc dodecyl benzene sulfonate12068-16-5NA 1123508Microbiocide,Soap, Inorganic-Zinc
Adjuvant,
Fungicide,
Insecticide
Cane syrupNA 228NA 4413598N/ACarbohydrate
Complex carbohydrate polymerNA 834NA 1544027AdjuvantCarbohydrate
derivative
Corn syrupNA 580NA 1053628BaitCarbohydrate
CornstarchNA 800NA 1483627N/ACarbohydrate
Dextrose50-99-7NA 3603129N/ACarbohydrate
Fructose7660-25-5NA 1775742N/ACarbohydrate
HoneyNA 734NA 1342595N/ACarbohydrate
Invert sugar8013-17-0NA 1713672BaitCarbohydrate
Invert syrupNA 941NA 1723673BaitCarbohydrate
Lactose63-42-3NA 1411400N/ACarbohydrate
Malt extract8002-48-0NA 1342659N/ACarbohydrate
MolassesNA 40NA 69744BaitCarbohydrate
Polysaccharide polymerNA 702NA 1292112AdjuvantCarbohydrate
Sorbitol50-70-4NA 2141629N/ACarbohydrate
Starch9005-84-9NA 8981821N/ACarbohydrate
Starch-G-poly (acrylamide-co-NA 494NA 8992888N/ACarbohydrate
sodium acrylate)
Sugar57-50-123708BaitCarbohydrate
Sweet n′ neat 45 spray driedNA 634NA 1163565N/ACarbohydrate
honey powder
Validamycin37248-47-8NA 190NA 189FungicideCarbohydrate
alpha-CelluloseNA 1537NA 225NA 224InsecticideCellulose derivative
Carbo methoxy ether cellulose,9004-32-4#####2446InsecticideCellulose derivative
sodium salt
Cellulose9004-34-6NA 4323100N/ACellulose derivative
Cellulose ethyl hydroxy ethyl9004-58-4NA 1133101N/ACellulose derivative
ether
Ethyl cellulose9004-57-3NA 2643652N/ACellulose derivative
Hydroxyethyl cellulose9004-62-0462011511N/ACellulose derivative
Hydroxypropyl methyl9004-65-3NA 1791969N/ACellulose derivative
cellulose
Methyl cellulose9004-67-5NA 851205N/ACellulose derivative
Microcrystalline cellulose9004-34-6NA 632686N/ACellulose derivative
Nitrocellulose9004-70-099601NA 867N/ACellulose derivative
(2-41289-08-1#####NA 101N/AUnclassified
chloroethyl)methylbis(phenylmethoxy)
silane
1% verde green solutionNA 553NA 1002982DyeUnclassified
1,2-dimethyl hydrazine540-73-0NA 1423165N/AUnclassified
1,2-epoxy butane106-88-7NA 1423190N/AUnclassified
1,3-butadiene106-99-0NA 4712431N/AUnclassified
1-((4-methyl-2-nitrophenyl)NA 43NA 802682N/AUnclassified
azo) naphthalenol
1-methyl pyrrolidine120-94-5NA 753287N/AUnclassified
1-Pentanethiol110-66-7#####NA 872N/AUnclassified
2,2′-octadecyl imino diethanol10213-78-2NA 203306N/AUnclassified
2,2′-oxybis (4,4,6-trimethyl-14697-50-812402792MicrobiocideUnclassified
1,3,2-dioxaborinane)
2-butanone oxime96-29-7NA 4743071N/AUnclassified
2-chloropyridine-N-oxideNA 219NA 4172466N/AUnclassified
2-ethyl hexanoic acid149-57-5#####3228N/AUnclassified
2-ethyl hexyl acrylate103-11-7NA 2522115N/AUnclassified
2-heptanone110-43-0NA 2063223N/AUnclassified
2-hydroxy-4-n-octylNA 572NA 1032608N/AUnclassified
benzophenone
2-mercapto pyridine2637-34-5NA 942671N/AUnclassified
2-nitro-1-butyl phosphate57249-19-1569022033N/AUnclassified
2-Nitropropane79-46-9#####3301ImpurityUnclassified
3′,6′-Dihydro-2′,4′,5′,7′-15905-32-5#####NA 981DyeUnclassified
tetraiodospiro(isobenzofuran-
1(3H),9′-(9H)xanthen)-3-one
4-hydroxydiphenylamine122-37-2NA 217NA 217BreakdownUnclassified
product
5-methyl-2-hexanone110-12-3NA 813230N/AUnclassified
Acetaldehyde75-07-0#####3012N/AUnclassified
Acetic anhydride108-24-7440073014N/AUnclassified
Acetone67-64-144101747SolventUnclassified
Acetonitrile75-05-8NA 6993015SolventUnclassified
Acetophenone98-86-2#####2074N/AUnclassified
Acid blue 182NA 599NA 1082353DyeUnclassified
Acid blue 7NA 385NA 7022352DyeUnclassified
Acid blue 9, diammonium salt2650-18-2#####2154Herbicide, DyeUnclassified
Acid blue 9, disodium salt3844-45-9#####3562Herbicide, DyeUnclassified
Acid yellow 231934-21-0#####2155Herbicide, DyeUnclassified
Acridinic basesNA 1356NA 193NA 192RepellentUnclassified
Acrylic acid79-10-7NA 1292118N/AUnclassified
AD-67NA 1378NA 195NA 194HerbicideUnclassified
Safener
AdjuvantsNA 1484NA 221NA 220AdjuvantUnclassified
Agent 1059-106NA 388NA 7082357N/AUnclassified
Agent 1059-108NA 600NA 1082358N/AUnclassified
Agent 1315-33ANA 389NA 7093881N/AUnclassified
Agent 1315-33NNA 390NA 7103879N/AUnclassified
Agent 1594-9NA 654NA 1203880N/AUnclassified
Agent 551-85NA 387NA 7072356N/AUnclassified
Agent W-218NA 391NA 7112359N/AUnclassified
Aldehyde C10112-31-2#####NA 107N/AUnclassified
Aldehyde C11112-44-7#####NA 107N/AUnclassified
Aldehyde C12112-54-9#####NA 107N/AUnclassified
Aldehyde C666-25-1#####NA 107N/AUnclassified
Aldehyde C8124-13-0#####NA 107N/AUnclassified
AldimorphNA 1340NA 188NA 187FungicideUnclassified
Aliphatic aminesNA 713NA 1302362N/AUnclassified
Alkanol XCNA 828NA 1523931AdjuvantUnclassified
Alkatronic PGP-33-4NA 395NA 7172363N/AUnclassified
Alkyl (C9H12) benzenesNA 310NA 5892371SolventUnclassified
Amine 22021652-27-7NA 1413033N/AUnclassified
Amines, aliphaticNA 277NA 5431747N/AUnclassified
Amino acidsNA 1359NA 193NA 192Plant GrowthUnclassified
Regulator
Ammonium propionateNA 1061NA 1585015Microbiocide,Unclassified
Preservative
Amsco-solvNA 271NA 5262386SolventUnclassified
Amygdalinic acid diethylNA 1448NA 215NA 214InsectUnclassified
amideRepellent
Amyl acetate628-63-71691889N/AUnclassified
Aniline62-53-3#####3056N/AUnclassified
Anionic wax emulsion61789-97-7NA 5153818N/AUnclassified
Anionic wax emulsionNA 892NA 1713848N/AUnclassified
Aquashade92170-50-8#####NA 909Herbicide, DyeUnclassified
Armul 1426NA 267NA 5223878N/AUnclassified
Armul 1426 HFNA 822NA 1513877N/AUnclassified
Armul 1427NA 268NA 5233883N/AUnclassified
Armul 1427 HFNA 589NA 1063876N/AUnclassified
Armul 214/215NA 265NA 5202391N/AUnclassified
Armul 22NA 263NA 5182389N/AUnclassified
Armul 33NA 587NA 1062390N/AUnclassified
Armul 358NA 266NA 5212392N/AUnclassified
Armul 646NA 588NA 1062393N/AUnclassified
Armul 88NA 264NA 5193908N/AUnclassified
Artificial peanut butter flavorNA 717NA 1312397N/AUnclassified
wl-5344
Astrazon yellow 4g200NA 258NA 5112399DyeUnclassified
Atlox 1045A61723-83-9NA 1523911N/AUnclassified
Atplus 300FNA 255NA 5073916N/AUnclassified
b-Bromo-b-nitrostyrene7166-19-0NA 221NA 221MicrobiocideUnclassified
Barochem B464NA 247NA 4992413N/AUnclassified
Basic violet 18004-87-3395033584DyeUnclassified
BCPNA 237NA 46564N/AUnclassified
Be-4526 phthalo blue lake r-cNA 244NA 4883518DyeUnclassified
Benfuresate68505-69-1NA 187NA 187HerbicideUnclassified
Bensultap17606-31-4NA 185NA 185InsecticideUnclassified
Benzene sulfonyl chloride98-09-9NA 4892415N/AUnclassified
Benzfendizone158755-95-4NA 230NA 230HerbicideUnclassified
Benzobicyclon156963-66-5NA 230NA 230HerbicideUnclassified
Benzofenap82692-44-2NA 211NA 211HerbicideUnclassified
Benzophenone-2131-55-5NA 4923063N/AUnclassified
Benzophenone-3119-61-93152417N/AUnclassified
Benzyl chloride100-44-7NA 4862419N/AUnclassified
Berol 927NA 894NA 1713874N/AUnclassified
Berol 968NA 893NA 1713873N/AUnclassified
Bethoxazin163269-30-5NA 230NA 230HerbicideUnclassified
BHA25013-16-5NA 4842420N/AUnclassified
Bicyclic and methene resinsNA 242NA 4853516N/AUnclassified
Bioban p-148737304-88-4#####1742MicrobiocideUnclassified
Biphenyl92-52-417002227Microbiocide,Unclassified
Fungicide
Bisphenol A80-05-7NA 4823070N/AUnclassified
Bisphenol F205672NA 216NA 215N/AUnclassified
Bispyribac125401-75-4NA 203NA 203HerbicideUnclassified
Bisthiosemi39603-48-0NA 206NA 206RodenticideUnclassified
Block polymer ofNA 850NA 1585011N/AUnclassified
carbonyldiamide
polyoxyalkylated glycol adduct
BrandolNA 1379NA 195NA 194FungicideUnclassified
Bromoacetic acid79-08-38702NA 102N/AUnclassified
Burgundy mixtureNA 1380NA 195NA 194FungicideUnclassified
Busan 1009NA 1564NA 227NA 227FungicideUnclassified
Butadiene-acrylonitrile9003-18-3NA 4722432N/AUnclassified
copolymer
Butane106-97-8NA 4731562N/AUnclassified
Buthiobate51308-54-4NA 206NA 206FungicideUnclassified
Butyl mercaptan109-79-5#####5087Deer Repellent,Unclassified
Bear Repellent
C-PA-1224 blackNA 191NA 3792483N/AUnclassified
Calcium propionate4075-81-4777012441PreservativeUnclassified
Cambendichlor56141-00-5NA 230NA 230HerbicideUnclassified
Capric acid334-48-5#####2315MicrobiocideUnclassified
Caprylic acid124-07-2#####2316MicrobiocideUnclassified
Caramel colorNA 720NA 1312444DyeUnclassified
Carfentrazone128621-72-7NA 210NA 210HerbicideUnclassified
Carfentrazone-ethyl128639-02-1#####5130HerbicideUnclassified
Carpropamid104030-54-8NA 203NA 203FungicideUnclassified
Cartap15263-53-3NA 181NA 181InsecticideUnclassified
Cartap hydrochloride22042-59-7NA 182NA 181InsecticideUnclassified
(unspecified hydrochloride)
Cartap monohydrochloride15263-52-2NA 182NA 181InsecticideUnclassified
Cetiol HE66105-29-1#####NA 871InsecticideUnclassified
CGA-154281NA 721NA 1322451N/AUnclassified
Chartersol-1NA 221NA 4282453SolventUnclassified
Chem-o-thane D-3860/D-3861NA 223NA 4302454N/AUnclassified
Chicago sludge68188-15-8NA 1473605N/AUnclassified
Chloracetic acid79-11-8#####3102N/AUnclassified
Chloral-bis-acylalNA 1344NA 191NA 191Plant GrowthUnclassified
Regulator
Chloral-semi-acetalNA 1345NA 191NA 191HerbicideUnclassified
ChloretazateNA 1403NA 197NA 196Plant GrowthUnclassified
Regulator
Chlorfenprop59404-06-7NA 181NA 180HerbicideUnclassified
Chlorfenprop-methyl14437-17-3#####NA 156HerbicideUnclassified
Chlorinated rubber2594016NA 4273606N/AUnclassified
Chlormethiuron28217-97-2NA 206NA 206InsecticideUnclassified
Chlorobenzene108-90-7565042460N/AUnclassified
Choline chloride67-48-1NA 191NA 190RodenticideUnclassified
Cinidon-ethyl142891-20-1NA 216NA 215HerbicideUnclassified
CitowettNA 218NA 4122471Soap/SurfactantUnclassified
Cloquintocet88349-88-6NA 219NA 218HerbicideUnclassified
Safener
Cloquintocet mexyl99607-70-2NA 191NA 190HerbicideUnclassified
Safener
Cloxyfonac32791-87-0NA 204NA 203Plant GrowthUnclassified
Regulator
Colgate crystal white handNA 202NA 3932476N/AUnclassified
dishwashing liquid
CollagenNA 203NA 3941805N/AUnclassified
Colloid 643NA 582NA 1052477N/AUnclassified
Colloid 840NA 791NA 1463527N/AUnclassified
CookiesNA 641NA 1173621BaitUnclassified
Credazine14491-59-9NA 207NA 206HerbicideUnclassified
CubietNA 1367NA 193NA 193Fungicide,Unclassified
Pruning Aid
Cyclohexanone108-94-125902177SolventUnclassified
Cyclopentadiene polymerNA 1450NA 215NA 214InsecticideUnclassified
Cymiazol hydrochloride61676-87-7NA 215NA 214InsecticideUnclassified
Cymoxanil57966-95-7#####4002FungicideUnclassified
Cyometrinil63278-33-1NA 207NA 206HerbicideUnclassified
Safener
Cysteine52-90-4NA 190NA 190Plant GrowthUnclassified
Regulator
D & C red no. 2818472-87-2#####3515DyeUnclassified
D & C red no. 371632455NA 1173634DyeUnclassified
D & C yellow 10 lake68814-04-0NA 3652487DyeUnclassified
D & C yellow no. 8NA 829NA 1523991DyeUnclassified
D-425NA 184NA 3672489N/AUnclassified
D-79 solventNA 183NA 3662488SolventUnclassified
Daxad 23NA 185NA 3682491N/AUnclassified
Day-glo saturn yellow AX-17-NNA 186NA 3692492DyeUnclassified
DE-570NA 1459NA 216NA 216N/AUnclassified
Delvet 65NA 177NA 3572494N/AUnclassified
Desoto urethane resinNA 179NA 3592497N/AUnclassified
Device (swimming poolNA 1503NA 222NA 222Algaecide,Unclassified
algaecide, bacteriacide,Microbiocide,
molluscicide) no guaranteeMolluscicide
required
Device, no guarantee requiredNA 1502NA 222NA 221N/AUnclassified
Di-1-p-mentheneNA 1381NA 195NA 194Plant GrowthUnclassified
Regulator
Diafenthiuron80060-09-9NA 186NA 185InsecticideUnclassified
Dichloro acetic acid79-43-6NA 1053133N/AUnclassified
Dichlorovinyl acidNA 174NA 3472502BreakdownUnclassified
product
Diclobutrazol75736-33-3NA 186NA 185FungicideUnclassified
Diclomezine62865-36-5NA 204NA 204FungicideUnclassified
Dicyclanil112636-83-6NA 211NA 211Insect GrowthUnclassified
Regulator
Dicyclopentadiene77-73-6NA 186NA 185Plant GrowthUnclassified
Regulator, Dog
and Cat
Repellent
Dicyclopentadiene linseed oil68213-53-631612NA 291N/AUnclassified
copolymer
Diethyl phosphate598-02-7NA 180NA 179BreakdownUnclassified
product
Diethyl sulfide352-93-2#####5088Bear RepellentUnclassified
Diethyldithio phosphate298-06-6NA 180NA 179BreakdownUnclassified
product
Diethylthio phosphate5871-17-0NA 180NA 179BreakdownUnclassified
product
Diisoamyl ketone2050-99-9NA 3253155SolventUnclassified
Diisobutyl ketone108-83-8441071946SolventUnclassified
Dikegulac18467-77-1NA 181NA 180HerbicideUnclassified
Dikegulac sodium52508-35-7#####2004Plant GrowthUnclassified
Regulator
Dimer acid6144-28-1NA 3303158N/AUnclassified
Dimethyl phosphate813-78-5NA 180NA 179BreakdownUnclassified
product
Dimethyl sulfoxide67-68-51773169SolventUnclassified
Dimethyldithio phosphate756-80-9NA 180NA 180BreakdownUnclassified
product
Dimethylthio phosphateNA 1339NA 180NA 179BreakdownUnclassified
product
Dioxane123-91-1NA 3002529Solvent,Unclassified
Impurity
Diphenyl methane101-81-5NA 3013171N/AUnclassified
Diphenylamine122-39-438501228Fungicide,Unclassified
Plant Growth
Regulator,
Insecticide
Dipropyl isocinchomerate3737-22-2NA 204NA 204InsectUnclassified
Repellent
Dipropyl isocinchomeronate136-45-847201681InsectUnclassified
Repellent
Dog or cat collarsNA 155NA 2913645N/AUnclassified
Dow Corning FG-10NA 147NA 2812541N/AUnclassified
Dowanol desg solventNA 725NA 1332538SolventUnclassified
Drewplus L-768NA 148NA 2832542N/AUnclassified
DyestuffsNA 689NA 1271913DyeUnclassified
Emcol AL69-49NA 726NA 1332544N/AUnclassified
Emphos CS-121NA 727NA 1332545Soap/SurfactantUnclassified
EmulgatorNA 143NA 2772546N/AUnclassified
Emulsogen CP 136NA 576NA 1042547AdjuvantUnclassified
Emulsogen NP 11-300NA 144NA 2782548AdjuvantUnclassified
Endothall145-73-3389015813Herbicide,Unclassified
Defoliant
Endothall, di (N,N-NA 949NA 2711355Herbicide,Unclassified
diethylalkylamine) saltDefoliant
Endothall, di (N,N-66330-88-9389051904Herbicide,Unclassified
dimethylalkylamine) saltDefoliant
Endothall, di(N,N-2536-26-738902NA 323Herbicide,Unclassified
dimethyltridecylamine) saltDefoliant
Endothall, diammonium salt17439-94-038908NA 326Herbicide,Unclassified
Defoliant
Endothall, dipotassium salt2164-07-0389041356Herbicide,Unclassified
Defoliant
Endothall, disodium salt129-67-938903260Herbicide,Unclassified
Defoliant
Endothall, mono (N,N-diethylNA 926NA 41354Herbicide,Unclassified
alkylamine) saltDefoliant
Endothall, mono [N,N-NA 929NA 612056Herbicide,Unclassified
dimethyl alkylamine] saltDefoliant
Endothall, mono(N,N-2536-27-838906NA 325Herbicide,Unclassified
dimethyltridecylamine) saltDefoliant
Endothall, N,N-NA 128238907NA 174Herbicide,Unclassified
dimethylcocamine salt (1:2)Algaecide
Epoxidized linseed oil2232670NA 2722550Insecticide,Unclassified
Adjuvant
Epoxy resinsNA 139NA 2693650N/AUnclassified
Erythrosine B16423-68-0#####2224Dye,Unclassified
Insecticide
Escorez 11029048-47-9NA 1463546N/AUnclassified
Espesol INA 140NA 2702552SolventUnclassified
Etacelasil37894-46-5NA 188NA 187Defoliant, PlantUnclassified
Growth
Regulator
Ethanethiol75-08-1NA 187NA 186RodenticideUnclassified
EthomeenNA 136NA 2652553N/AUnclassified
Ethyl acrylate140-88-5NA 2592117N/AUnclassified
Ethyl formate109-94-443102278Fumigant,Unclassified
Insecticide
Ethyl methacrylate97-63-2NA 2483203N/AUnclassified
Ethylene-acrylic acid9010-77-9NA 2533653AdjuvantUnclassified
copolymer
Ethylene-acrylic terpolymerNA 133NA 2541950AdjuvantUnclassified
Ethylhexanoate123-66-0NA 190NA 190Fungicide,Unclassified
Microbiocide
ExtenderNA 1377NA 195NA 194SynergistUnclassified
Fatty alcoholsNA 1364NA 193NA 192Plant GrowthUnclassified
Regulator,
Adjuvant
FD&C blue no. 1 aluminum53026-57-6NA 2423000DyeUnclassified
lake
FD&C green no. 3NA 127NA 2432566DyeUnclassified
FD&C red no. 40NA 947#####2567Dye, ImpurityUnclassified
Feed supplementsNA 128NA 2443655N/AUnclassified
Fenchlorazole103112-35-2NA 181NA 181HerbicideUnclassified
Safener
Fenchlorim3740-92-9NA 182NA 181HerbicideUnclassified
Safener
Fenitropan65934-95-4NA 207NA 207FungicideUnclassified
Fenpiclonil74738-17-3NA 188NA 187FungicideUnclassified
Fenpropidin67306-00-7NA 184NA 183FungicideUnclassified
Fenpropimorph67306-03-0#####NA 988FungicideUnclassified
Fenpropimorph67564-91-4NA 201NA 200FungicideUnclassified
FenthiosulfNA 1406NA 198NA 197InsecticideUnclassified
Fertilizer, generalNA 729NA 1332569N/AUnclassified
Filter paper e-d-601-25NA 122NA 2353525N/AUnclassified
Flomo 1212NA 124NA 2392572Soap/SurfactantUnclassified
Flomo 4NPNA 616NA 1122573Soap/SurfactantUnclassified
FlorasulamNA 1447NA 214NA 214HerbicideUnclassified
Flubenzimine (unstated37893-02-0NA 188NA 187InsecticideUnclassified
stereochemistry)
Flumequine42835-25-6NA 188NA 187MicrobiocideUnclassified
Flumiclorac87547-04-4NA 232NA 232HerbicideUnclassified
Flumipropyn84478-52-4NA 229NA 229HerbicideUnclassified
Flupropanate756-09-2NA 204NA 204HerbicideUnclassified
Flupropanate, sodium salt22898-01-7NA 211NA 211HerbicideUnclassified
Flurazole72850-64-7NA 187NA 186HerbicideUnclassified
Safener
Flurtamone96525-23-4NA 217NA 216HerbicideUnclassified
Fluthiacet149253-65-6NA 205NA 204HerbicideUnclassified
Fluxofenim88485-37-4NA 202NA 201HerbicideUnclassified
Safener
Formaldehyde50-00-043001295Microbiocide,Unclassified
Fungicide
Fosetyl-A139148-24-8#####2210FungicideUnclassified
Fragrance 1256 HNA 115NA 2272575FragranceUnclassified
Fragrance for mosquito51843NA 1403007FragranceUnclassified
repellent p-7510
Fragrance N-5716NA 116NA 2283852FragranceUnclassified
Fragrance orange 418228NA 117NA 2293889FragranceUnclassified
Fragrance PNLF 6986NA 633NA 1163563FragranceUnclassified
Fragrance RS-2661NA 824NA 1513891FragranceUnclassified
Frambinone5471-51-2NA 212NA 212FragranceUnclassified
Fumaric acid110-17-851201297N/AUnclassified
Fumaric and crotonic acids,NA 118NA 2301711N/AUnclassified
esters of
FumigantsNA 1492NA 221NA 221FumigantUnclassified
Furaneol 15% p.g.NA 119NA 2312576N/AUnclassified
Furfural98-01-1433011522N/AUnclassified
Gentian97676-22-7#####NA 108DyeUnclassified
Gentian violet548-62-9395021270Microbiocide,Unclassified
Dye
Gentian violet548-62-998401NA 173Microbiocide,Unclassified
Dye
Givaudan muquet PA-6664NA 575NA 1042580N/AUnclassified
Glidden no. 3200 white latexNA 113NA 2242581N/AUnclassified
GlueNA 643NA 1183661N/AUnclassified
Glufosinate51276-47-2NA 203NA 202HerbicideUnclassified
Glufosinate-ammonium77182-82-2#####3946HerbicideUnclassified
Grease (bands, fruit frees)NA 1350NA 192NA 191InsecticideUnclassified
Green M liquid dyeNA 106NA 2113840DyeUnclassified
Heptopargil73886-28-9NA 208NA 207Plant GrowthUnclassified
Regulator
Heptyl butyrate5870-93-9NA 2073668N/AUnclassified
Hi-sol 15NA 97NA 1922594SolventUnclassified
Hostaphat MDAR-N-040NA 98NA 1932596N/AUnclassified
Hostapon T powder highly97-80-3NA 1713942N/AUnclassified
concentrated
Hydrazine302-01-2NA 1952598Impurity,Unclassified
Breakdown
product
Hydrolysed linseed fatty acidNA 1436NA 212NA 212N/AUnclassified
Hydroxyl amine sulfate10039-54-0NA 1813235N/AUnclassified
Hydroxyphenyl-salicylamideNA 1396NA 197NA 196FungicideUnclassified
Inabenfide82211-24-3NA 205NA 204Plant GrowthUnclassified
Regulator
Indanofan133220-30-1NA 232NA 232HerbicideUnclassified
Indigo carmine860-22-0NA 1463530DyeUnclassified
Inert (VOC reevaluation)NA 877NA 1693973N/AUnclassified
Inert ingredientsNA 872NA 1600N/AUnclassified
Instex 10100 color concentrateNA 88NA 1702615DyeUnclassified
(black)
Irganox 10106683-19-8NA 1733623N/AUnclassified
Irganox 10106683-19-8NA 1703523N/AUnclassified
Irganox 10762082-79-3NA 1742617N/AUnclassified
Iso-amyl mercaptan541-31-1NA 213NA 212N/AUnclassified
Isobutyl acetate110-19-0NA 1433241N/AUnclassified
Isobutyric acid79-31-2#####2110PreservativeUnclassified
Isooctyl phosphate12645-53-3NA 1623258Soap/Surfactant,Unclassified
Adjuvant
Isopropanolamine nitriteNA 87NA 1663245N/AUnclassified
Isopropylamine75-31-0NA 1573246N/AUnclassified
Isoprothiolane50512-35-1NA 189NA 188FungicideUnclassified
IsovalNA 1385NA 195NA 195RodenticideUnclassified
Isoxapyrifop87757-18-4NA 208NA 208HerbicideUnclassified
Ivory snowNA 75NA 1463674N/AUnclassified
K 1A112NA 77NA 1482628N/AUnclassified
Kelsol 513468309-52-4NA 1493526SolventUnclassified
Ketoconazole65277-42-1NA 216NA 215FungicideUnclassified
Korax2425-66-311302351N/AUnclassified
Krynac 1122NA 79NA 1512632N/AUnclassified
Latex paintNA 74NA 1442634N/AUnclassified
Leonil DB powderNA 71NA 1392639N/AUnclassified
LignoflexNA 68NA 1313265N/AUnclassified
Limonia 19-11189NA 69NA 1322643N/AUnclassified
Linseed-soya alkyd resinNA 62NA 1172646N/AUnclassified
Lithium29457-72-5750045678Insecticide,Unclassified
(perfluorooctane)sulfonateAdjuvant
Long oil alkyd 5070NA 64NA 1202648InsecticideUnclassified
Lubrizol 544NA 65NA 1212649Solvent,Unclassified
Adjuvant
Luna yellow NB-1 1270NA 66NA 1222651DyeUnclassified
Luviset cap25035-26-1NA 1233867N/AUnclassified
Macroplast UK 8202/UK 5400NA 57NA 1082652N/AUnclassified
Macroplast VAX-11688/UKNA 58NA 1092653N/AUnclassified
5400
Malachite green569-64-239504366DyeUnclassified
Maleic anhydride108-31-6NA 1023272N/AUnclassified
Maleic anhydride, polymer37199-81-8NA 1033271N/AUnclassified
with 2,4,4-trimethyl pentane,
sodium salt
Maleic hydrazide123-33-151501368Plant GrowthUnclassified
Regulator
Maleic hydrazide10071-13-3NA 210NA 209Plant GrowthUnclassified
Regulator
Maleic hydrazide, choline salt71203-19-551504NA 422Plant GrowthUnclassified
Regulator
Maleic hydrazide,5716-15-451502778Plant GrowthUnclassified
diethanolamine saltRegulator
Maleic hydrazide, potassium28382-15-2515032130Plant GrowthUnclassified
Regulator,
Herbicide
Malic acid6915-15-7511011364MicrobiocideUnclassified
Mark 1500NA 49NA 962663N/AUnclassified
Mark 1600NA 50NA 972664N/AUnclassified
Mark 1601NA 51NA 982665N/AUnclassified
Mark 1603NA 740NA 1352666N/AUnclassified
Mark 1607NA 569NA 1032667N/AUnclassified
Mark 495NA 56NA 1072660N/AUnclassified
Mark 565ANA 48NA 952661N/AUnclassified
Mark 706NA 739NA 1352662N/AUnclassified
Marter white 400NA 52NA 992668N/AUnclassified
Medicated blockNA 47NA 923684N/AUnclassified
Mefenpyr135591-00-3NA 182NA 181HerbicideUnclassified
Safener
Mefenpyr-diethyl135590-91-9R47618NA 177HerbicideUnclassified
Safener
Menhaden oil8002-50-4NA 933686N/AUnclassified
Menthol1490-04-6516011074Dog and CatUnclassified
Repellent
Methoxy-2,4-dihydroxyNA 46NA 893281N/AUnclassified
pentene
Methoxyphenone41295-28-7NA 209NA 208HerbicideUnclassified
Methyl esters of cottonseed oil61788-60-1NA 1483687AdjuvantUnclassified
Methyl ethyl ketone78-93-3441032680SolventUnclassified
Methyl formate107-31-353701391FumigantUnclassified
Methyl hydrogenated rosinate8050-15-5NA 823688N/AUnclassified
Methyl isocyanate624-83-9NA 180NA 180BreakdownUnclassified
product
Methyl isothiocyanate556-61-668103392Fumigant,Unclassified
Insecticide,
Herbicide,
Nematicide,
Breakdown
product
Methyl methacrylate80-62-6NA 782151N/AUnclassified
Methylene blue61-73-439505387Fungicide, DyeUnclassified
Metosulam139528-85-1NA 184NA 184HerbicideUnclassified
Milorganite68512-89-0NA 663693N/AUnclassified
MKH 6561NA 1466NA 217NA 216HerbicideUnclassified
MON 466071526-07-3#####NA 162N/AUnclassified
Monosodium glutamate32221-81-1NA 592691N/AUnclassified
Morwet EFWNA 36NA 602693AdjuvantUnclassified
Morwet IPNA 568NA 1023694AdjuvantUnclassified
Morwet IPNA 887NA 1702694AdjuvantUnclassified
Multiresidue carbamate screenNA 848NA 1584042N/AUnclassified
Multiresidue chlorinatedNA 847NA 1584043N/AUnclassified
hydrocarbon screen
Multiresidue organophosphateNA 846NA 1584044N/AUnclassified
screen
Multiresidue triazine screenNA 845NA 1574045N/AUnclassified
N,N-Diallyl-2,2-37764-25-3NA 187NA 186HerbicideUnclassified
dichloroacetamideSafener
n-Butyl acetate142-62-1#####2434N/AUnclassified
N-methyl-2-pyrrolidone237900NA 762684N/AUnclassified
N-TDFNA 22NA 342713N/AUnclassified
Naphthalene-formaldehyde9008-63-3NA 582692Insecticide,Unclassified
condensate sulfonic acid,Fungicide,
metallic saltsMicrobiocide,
Adjuvant
Naphthalic anhydride81-84-5NA 209NA 208HerbicideUnclassified
Safener
Neo-decanoic acid26896-20-8975012699N/AUnclassified
Neodol 2563393-82-8NA 513930N/AUnclassified
Neuessence powder 411669NA 781NA 1403003N/AUnclassified
Nipyraclofen99662-11-0NA 229NA 229HerbicideUnclassified
Nitrile rubberNA 743NA 1352704N/AUnclassified
Nitro ethane79-24-3NA 493298SolventUnclassified
Nitromethane75-52-5NA 423299SolventUnclassified
Nitrothal-isopropyl10552-74-6NA 181NA 180FungicideUnclassified
Non-ionic surfactantsNA 1443NA 214NA 213Soap/Surfactant,Unclassified
Adjuvant
Nonoxynol-9-phosphateNA 29NA 432706AdjuvantUnclassified
Norbormide991-42-4862012711N/AUnclassified
Nuostabe v-1913NA 23NA 352715N/AUnclassified
Nuxtra calcium 6% catalystNA 25NA 372716N/AUnclassified
Nuxtra calcium 8% catalystNA 26NA 382717N/AUnclassified
Nuxtra manganese 9% catalystNA 15NA 242718N/AUnclassified
Nylon32131-17-2NA 253703N/AUnclassified
Octachlorostyrene29082-74-4NA 215NA 215N/AUnclassified
Orvus ES paste concentrateNA 3NA 32726N/AUnclassified
Ovex80-33-120201452Insect GrowthUnclassified
Regulator
Oxabetrinil74782-23-3NA 205NA 204HerbicideUnclassified
Safener
Oxadiargyl39807-15-3NA 211NA 211HerbicideUnclassified
Oxapyrazon4489-31-0NA 209NA 208HerbicideUnclassified
Oxapyrazon sodium25316-56-7NA 217NA 217HerbicideUnclassified
Oxaziclomefone153197-14-9NA 233NA 233HerbicideUnclassified
Oxidized polyethylene68441-17-8NA 1183713N/AUnclassified
Oxygenated solventsNA 379NA 6871767SolventUnclassified
p-Chloronitrobenzene100-00-5NA 183NA 182InsecticideUnclassified
PaintNA 380NA 6883715N/AUnclassified
Panasol AN-2NA 381NA 6902733SolventUnclassified
Panasol AN-3NA 382NA 6912732SolventUnclassified
Paraformaldehyde30525-89-443002456Microbiocide,Unclassified
Fungicide,
Insecticide
Pareth 91-8NA 889NA 1702734N/AUnclassified
Pentoxazone110956-75-7NA 233NA 233HerbicideUnclassified
Perfluorooctane sulfonateNA 1456NA 216NA 215InsecticideUnclassified
Perfume 08-28NA 750NA 1362740FragranceUnclassified
Perfume bouquet no. 3NA 366NA 6722741FragranceUnclassified
Perfume, chem-mask C no. 280NA 367NA 6732742FragranceUnclassified
Perfume, colonial bouquetNA 368NA 6742744FragranceUnclassified
8095
Perfume, compound 2-2723NA 752NA 1362745FragranceUnclassified
Perfume, compound 44.368/gNA 370NA 6762747FragranceUnclassified
Perfume, compound bouquetNA 369NA 6752746FragranceUnclassified
EC
Perfume, DL 10613NA 823NA 1513888FragranceUnclassified
Perfume, eaudesol malNA 371NA 6772748FragranceUnclassified
(special)
Perfume, fragrance oil 6198NA 372NA 6782750FragranceUnclassified
AG
Perfume, fresh meadows #651NA 753NA 1362751FragranceUnclassified
Perfume, herbal fragrance oilNA 354NA 6572753FragranceUnclassified
no. 062
Perfume, malamasque no. 59NA 355NA 6582754FragranceUnclassified
Perfume, malathion 21-639NA 356NA 6592755FragranceUnclassified
Perfume, marbelle 72160ANA 357NA 6602756FragranceUnclassified
Perfume, mimosa no. 5NA 754NA 1362757FragranceUnclassified
Perfume, neutroleum alphaNA 358NA 6612758FragranceUnclassified
Perfume, new mown hayNA 359NA 6622759FragranceUnclassified
Perfume, norda EC-137NA 360NA 6632760FragranceUnclassified
Perfume, pet perfume # 27253NA 361NA 6642761FragranceUnclassified
Perfume, phase b-5NA 755NA 1362762FragranceUnclassified
Perfume, R-7402NA 362NA 6652763FragranceUnclassified
Perfume, veilex 40019NA 363NA 6662764FragranceUnclassified
Perfume, washroom cleanerNA 364NA 6672765FragranceUnclassified
bouquet # 152-587
Phenyl ether101-84-8NA 6533324N/AUnclassified
PhosametineNA 1400NA 197NA 196HerbicideUnclassified
Phosdiphen36519-00-3NA 209NA 209FungicideUnclassified
PhosphoproteinsNA 350NA 6461250N/AUnclassified
Phthalaldehyde643-79-8#####5107MicrobiocideUnclassified
Phthalide27355-22-2NA 205NA 205FungicideUnclassified
Phthalo greenNA 348NA 6422779DyeUnclassified
PicaridinNA 1434NA 212NA 211InsectUnclassified
Repellent
Pigment blue 2957455-37-5NA 6432780DyeUnclassified
Pigment green 71328-53-6NA 6363870DyeUnclassified
Pigment red 1783049-71-6NA 6373869DyeUnclassified
Pigment red 57:16887-51-9NA 1713868DyeUnclassified
Pigment red no. 4816013-44-8NA 1493729DyeUnclassified
Pimaricin7681-93-8NA 203NA 202FungicideUnclassified
Piperalin3478-94-297003488FungicideUnclassified
Piperine94-62-2NA 223NA 223N/AUnclassified
Piproctanyl69309-47-3NA 209NA 209Plant GrowthUnclassified
Regulator
Piproctanyl bromide56717-11-4NA 218NA 217Plant GrowthUnclassified
Regulator
Plastic polymersNA 339NA 625764AdjuvantUnclassified
Plurafac B-2669227-21-0NA 6262782N/AUnclassified
Plurafac C-1769227-21-0NA 1372783N/AUnclassified
Pluraflo E4ANA 340NA 6272784Soap/SurfactantUnclassified
Pluronic 10-R-5NA 345NA 6322790N/AUnclassified
Pluronic 1-101NA 759NA 1372788N/AUnclassified
Pluronic L-62 LFNA 342NA 6292786N/AUnclassified
Pluronic L61NA 341NA 6282785N/AUnclassified
Pluronic 163NA 343NA 6302787N/AUnclassified
Pluronic P-104NA 344NA 6312789N/AUnclassified
PMS-5406-T pigmentNA 346NA 6332791N/AUnclassified
Po-san37339-61-098804NA 861N/AUnclassified
Po-san76930-44-498804NA 862N/AUnclassified
Poly(oxyethylene)31512-74-0691831576MicrobiocideUnclassified
(dimethylimino) ethylene
(dimethylimino) ethylene
dichloride
Poly-i-para-menthene34363-01-4NA 6101314Insect GrowthUnclassified
Regulator
Polyacrylamide polymer2592984NA 6342111AdjuvantUnclassified
Polyalkylene etherNA 347NA 6352271AdjuvantUnclassified
Polyamide resinNA 621NA 1122795N/AUnclassified
Polyamine polymerNA 334NA 6201907AdjuvantUnclassified
Polyhexamethylene32289-58-0#####2258Microbiocide,Unclassified
biguanidineFungicide
Polymer emulsion KNA 329NA 6112804AdjuvantUnclassified
Polymerized acrylic acid2592860529023738AdjuvantUnclassified
Polyoxin11113-80-7NA 194NA 193FungicideUnclassified
PolyurethaneNA 426NA 7683770N/AUnclassified
Polyvinyl butyral resinNA 427NA 7692820N/AUnclassified
Polyvinyl chloride9002-86-2NA 7702821N/AUnclassified
Polyvinylpyrrolidone-82010-83-143003NA 367MicrobiocideUnclassified
formaldehyde complex
Polyvis O-SHNA 428NA 7712823N/AUnclassified
Poly[hydroxyethylene(dimethyliminio)NA 1512NA 223NA 222MicrobiocideUnclassified
ethylene(dimethylimino)
methylene dichloride]
Potassium 3-(2-(2-((2-(2-NA 998NA 7793352PreservativeUnclassified
hydroxy ethyl) ethyl) octadecyl
amino)ethoxy) propionate
Potassium N-ethyl perfluoroNA 997NA 7773354Insecticide,Unclassified
octane sulfonamide acetateAdjuvant
Probenazole27605-76-1NA 205NA 205Fungicide,Unclassified
Microbiocide
Propellant A-46NA 441NA 7942834PropellantUnclassified
Propellant A-70NA 762NA 1372835PropellantUnclassified
Propellant A-91NA 442NA 7952836PropellantUnclassified
Propellant B-46NA 443NA 7963887PropellantUnclassified
PropidineNA 1449NA 215NA 214InsectUnclassified
Repellent
Propionic acid79-09-477702505Fungicide,Unclassified
Microbiocide,
Preservative
Propyl-3-t-butylphenoxyacetateNA 1407NA 198NA 197Plant GrowthUnclassified
Regulator
Pyrazolynate58011-68-0NA 205NA 205HerbicideUnclassified
Pyribenzoxim168088-61-7NA 233NA 233HerbicideUnclassified
Pyriminobac136191-56-5NA 206NA 205HerbicideUnclassified
Pyroquilone57369-32-1NA 190NA 189FungicideUnclassified
Quinacetol sulfate57130-91-3NA 210NA 209FungicideUnclassified
Quinizarin green SS128-80-3NA 1093374DyeUnclassified
Quinoclamine2797-51-5NA 185NA 184Herbicide,Unclassified
Algaecide
Quinoxyfen124495-18-7NA 206NA 205FungicideUnclassified
Resins and polymersNA 1374NA 194NA 193Pruning Aid,Unclassified
Adjuvant
RH - 2485NA 1467NA 217NA 217InsecticideUnclassified
Rhodamine B81-88-9NA 1382846DyeUnclassified
Sebacic acid111-20-6NA 187NA 186RepellentUnclassified
Sec-butylamine13952-84-642141704FungicideUnclassified
Seconal76-73-3NA 190NA 189N/AUnclassified
Secret formula no. 1NA 2NA 21837N/AUnclassified,
Unclassified
Secret formula no. 2NA 458NA 8201838N/AUnclassified
Silthiofam175217-20-6NA 210NA 210FungicideUnclassified
Sintofen130561-48-7NA 185NA 184Plant GrowthUnclassified
Regulator
Sodium 2-ethylhexanoate19766-89-3NA 214NA 214Fungicide,Unclassified
Microbiocide
Sodium caprylate29372790633388N/AUnclassified
Sodium chloroacetate3926-62-3#####NA 141HerbicideUnclassified
Sodium diacetoneketogulonateNA 1397NA 197NA 196Plant GrowthUnclassified
Regulator
Sodium gluconate527-07-11053406N/AUnclassified
Sodium methyl sulfate512-42-5NA 1453417N/AUnclassified
Sodium petroleum sulfonate68608-26-4790353431Insecticide,Unclassified
Adjuvant
Sodium propionate137-40-6777033434Fungicide,Unclassified
Preservative
Solulan 98NA 474NA 8742867SolventUnclassified
Solulan L-575NA 763NA 1382868N/AUnclassified
Solvent red 49509-34-2NA 8753900DyeUnclassified
Spiroxamine118134-30-8NA 202NA 202FungicideUnclassified
Sponto 168NA 484NA 8882875N/AUnclassified
Sponto 232TNA 492NA 8962885N/AUnclassified
Sponto 234TNA 766NA 1382886N/AUnclassified
Sponto AK-30-02BTNA 485NA 8892876N/AUnclassified
Sponto AK31-27ANA 764NA 1382877N/AUnclassified
Sponto AK31-27BNA 486NA 8902878N/AUnclassified
Sponto AK31-38NA 487NA 8912879N/AUnclassified
Sponto AK31-56ANA 488NA 8922880N/AUnclassified
Sponto AK31-56BNA 765NA 1382881N/AUnclassified
Sponto AK31-56MNA 632NA 1163558N/AUnclassified
Sponto N-140BNA 489NA 8932882N/AUnclassified
Sponto N-300BNA 490NA 8942883N/AUnclassified
Sponto N-500BNA 491NA 8952884N/AUnclassified
Sta-pro 3000NA 493NA 8972889N/AUnclassified
Stepan C-65 methyl esterNA 496NA 9032893N/AUnclassified
Stepantan ANA 497NA 9042894N/AUnclassified
Stepfac 8172NA 767NA 1382895N/AUnclassified
SterilixNA 656NA 121550MicrobiocideUnclassified
Sterox NJNA 498NA 9052896N/AUnclassified
Stoddard solvent8052-41-363504NA 516Solvent,Unclassified
Herbicide,
Insecticide
Styrene acrylic copolymer25085-34-1NA 9073457AdjuvantUnclassified
Styrene/pvp copolymer25086-29-7NA 9083812AdjuvantUnclassified
Sudan III85-86-9NA 9093459DyeUnclassified
Sulcotrione99105-77-8NA 185NA 184HerbicideUnclassified
Sulfated dipentaneNA 500NA 9113460N/AUnclassified
Sulfonated cod liver oilNA 1464NA 217NA 216N/AUnclassified
Sulglycapin51068-60-1NA 233NA 233HerbicideUnclassified
Sure sol 180NA 505NA 9162903SolventUnclassified
Surflo B11NA 606NA 1102904Soap/SurfactantUnclassified
Surflo B13NA 506NA 9172905Soap/SurfactantUnclassified
Surflo B16NA 507NA 9182906Soap/SurfactantUnclassified
Surflo B17NA 508NA 9192907Soap/SurfactantUnclassified
Surflo B19NA 770NA 1392908Soap/SurfactantUnclassified
Sustane 3NA 622NA 1132909N/AUnclassified
T-DETN-9.5NA 513NA 9282917N/AUnclassified
T-mulz 565NA 528NA 9552944AdjuvantUnclassified
T-mulz 94WNA 531NA 9582949AdjuvantUnclassified
T-mulz AO2NA 772NA 1392943N/AUnclassified
T-mulz ONA 529NA 9562945AdjuvantUnclassified
T-mulz PBNA 530NA 9572946AdjuvantUnclassified
T-Mulz VONA 610NA 1112947N/AUnclassified
T-mulz WNA 773NA 1392948N/AUnclassified
Tabu powderNA 510NA 9221462N/AUnclassified
TacksNA 818NA 1513816N/AUnclassified
Tenneco 225F PVC resinNA 514NA 9302919N/AUnclassified
Tenneco T500-100NA 771NA 1392920N/AUnclassified
Tenox 2NA 515NA 9312921PreservativeUnclassified
Tenox 4NA 516NA 9322922PreservativeUnclassified
Tenox RNA 517NA 9332923PreservativeUnclassified
Tenox S-1NA 518NA 9342924PreservativeUnclassified
Tensiofix B7416NA 895NA 1713943Soap/SurfactantUnclassified
Tensiofix B7453NA 896NA 1713944Soap/SurfactantUnclassified
Tergitol 15-S-12NA 623NA 1132926N/AUnclassified
Tergitol 15-S-12 acrylateNA 519NA 9352927N/AUnclassified
Tergitol 15-S-20NA 520NA 9362928N/AUnclassified
tert-Butylamine Endothall26648-01-138909NA 327Herbicide,Unclassified
Defoliant
Tetrahydrofuran109-99-9NA 9442933SolventUnclassified
Texaphor specialNA 524NA 9512935N/AUnclassified
TF-310NA 525NA 9523524N/AUnclassified
Thanite115-31-147101586InsecticideUnclassified
Thickener, unknownNA 526NA 9532936AdjuvantUnclassified
Thicyofen116170-30-0NA 210NA 209FungicideUnclassified
Thidiazimin123249-43-4NA 230NA 229HerbicideUnclassified
Thiocyclam31895-21-3NA 182NA 181InsecticideUnclassified
Thiocyclam hydrogen oxalate31895-22-4#####NA 104InsecticideUnclassified
Thixatrol STNA 820NA 1513853N/AUnclassified
Toximul 500NA 532NA 9632951InsecticideUnclassified
Toximul 850 mNA 826NA 1523918N/AUnclassified
Toximul DNA 533NA 9642952N/AUnclassified
Toximul HNA 534NA 9652953N/AUnclassified
Toximul PNA 774NA 1402954N/AUnclassified
Toximul TA-5NA 535NA 9662955N/AUnclassified
Triapenthenol76608-88-3NA 190NA 189Plant GrowthUnclassified
Regulator
Triaryl methaneNA 536NA 9672957N/AUnclassified
Triazoxide72459-58-6NA 185NA 184FungicideUnclassified
Tributyl phosphate126-73-8NA 9693480N/AUnclassified
Trichlamide70193-21-4NA 210NA 209FungicideUnclassified
TrichloropyridinolNA 1338NA 180NA 179BreakdownUnclassified
product
Tridemorph24602-86-6#####NA 987FungicideUnclassified
Tridemorph81412-43-3#####NA 201FungicideUnclassified
Triethyl phosphate78-40-0NA 9793489N/AUnclassified
Trioxymethylene110-88-3NA 190NA 189Microbiocide,Unclassified
Fungicide
Triton CF-10NA 542NA 9912968Soap/SurfactantUnclassified
Triton X-363NA 612NA 1112969Soap/SurfactantUnclassified
Trycol NP-4NA 775NA 1402970N/AUnclassified
Trycol NP-6NA 543NA 9932971N/AUnclassified
Trycol NP-9NA 544NA 9942972N/AUnclassified
Tryfac 5566NA 545NA 9952973N/AUnclassified
Tryfac 910-KNA 546NA 9962974N/AUnclassified
TurgaseptNA 776NA 1402975N/AUnclassified
Ucar solution vinyl VAGHNA 548NA 9992976N/AUnclassified
UL-94 HF1 listed polyesterNA 549NA 1002977N/AUnclassified
foam
Unknown (In EPA ProductNA 117567323NA 165FungicideUnclassified
data w/o name)
Unknown (In EPA ProductNA 117669144NA 165MicrobiocideUnclassified
data w/o name)
Unknown (In EPA ProductNA 117769162NA 165MicrobiocideUnclassified
data w/o name)
Unknown (In EPA ProductNA 117879061NA 165MicrobiocideUnclassified
data w/o name)
Unknown (In EPA ProductNA 1179#####NA 166MicrobiocideUnclassified
data w/o name)
Unknown (In EPA ProductNA 1180#####NA 166MicrobiocideUnclassified
data w/o name)
Unknown (In EPA ProductNA 1181#####NA 166MicrobiocideUnclassified
data w/o name)
Unknown (In EPA ProductNA 1182#####NA 166N/AUnclassified
data w/o name)
Unknown (In EPA ProductNA 1183#####NA 166N/AUnclassified
data w/o name)
Urethane adhesive, parts a & bNA 551NA 1002979N/AUnclassified
Versalon 1112NA 613NA 1112984N/AUnclassified
Versamid resinsNA 651NA 1193822N/AUnclassified
Vinyl acetate108-05-4NA 1002116N/AUnclassified
Vinyl polymerNA 680NA 1251754AdjuvantUnclassified
Vinyl resin, syntheticNA 554NA 1001533N/AUnclassified
Vitamin K358-27-56319NA 89N/AUnclassified
Water soluble dyesNA 1517NA 223NA 223DyeUnclassified
WaxesNA 1376NA 194NA 194Pruning Aid,Unclassified
Adjuvant
Wickenol 535NA 779NA 1402989N/AUnclassified
Wing stay VNA 561NA 1012990N/AUnclassified
Witafrol 7420NA 625NA 1132991N/AUnclassified
Witcamine tam-45NA 562NA 1012992N/AUnclassified
Witco C-5752NA 563NA 1013882N/AUnclassified
Witconate p-1020buNA 614NA 1113884N/AUnclassified
Witconol 1S-108NA 564NA 1012993N/AUnclassified
Zein9010-66-6NA 1023504N/AUnclassified
|
*N/A = Not Available\
|
II. Augmenting the Sensitivity of Plants to Herbicides
In certain embodiments of the invention, the effectiveness of herbicides is augmented by methods and compositions for the contemporaneous administration of one or more ectophosphatase inhibitors in combination with herbicides. Such applications may, in addition to increasing the effectiveness of herbicides, allow the use of reduced concentrations of herbicides, thereby providing cost and environmental benefits.
Specifically contemplated by the invention are compositions comprising one or more ectophosphatase inhibitor(s) in combination with one or more herbicide(s) listed in Table 1. In one embodiment of the invention, the ectophosphatase inhibitor may or may not be a compound selected from formula I-XX. The herbicidal compositions or other compositions formulated for agricultural use, including compositions comprising insecticides and growth regulators, may be used with potentially any plant. The term “plant,” as used herein, refers to any type of plant. The inventors have provided below an exemplary description of some plants that may be used with the invention. However, the list is provided for illustrative purposes only and is not limiting, as other types of plants will be known to those of skill in the art and could be used with the invention.
Non-limiting examples of plant genera that may be treated in accordance with the invention include: Abutilon, Amaranthus, Artemisia, Asclepias, Avena, Axonopus, Borreria, Brachiaria, Brassica, Bromus, Chenopodium, Cirsium, Commelina, Convolvulus, Cynodon, Cyperus, Digitaria, Echinochloa, Eleusine, Elymus, Equisetum, Erodium, Helianthus, Imperata, Ipomoea, Kochia, Lolium, Malva, Oryza, Ottochloa, Panicum, Paspalum, Phalaris, Phragmites, Polygonum, Portulaca, Pteridium, Pueraria, Rubus, Salsola, Setaria, Sida, Sinapis, Sorghum, Triticum, Typha, Ulex, Xanthium, and Zea. Non-limiting common types of plants that may be controlled in accordance with the invention include varieties of grasses, broad leafs, succulents, trees and shrubs, barley, black nightshade, broadleaf signal grass, burcumber, chickweed, common ragweed, crabgrass, field pennycress, rough fleabane, foxtail, giant ragweed, goose grass, groundcherry, hemp sesbarria, henbit, jungle rice, kochia, lambs quarters, morning-glory spp., mustard, fall and Texas panicum, palma amaranth, prickly sida (teaweed), red rice, rye, seedling shattercone, shepherd's purse, sicklepod, sprangletop, sunflower, velvet leaf, volunteer corn, common and tall waterhemp, wheat, wild proso millet, witchgrass, wolly cupgrass; and common perennial weeds including Canada thistle, common milkweed, field bindweed, hemp dogbane, red vine, rhizone johnson grass, tall fescue, trumpet creeper, swamp smartweed and wisteria mukly. Star Thistle, Poison Oak, and Ivy.
Non-limiting examples of species that may be controlled include velvetleaf (Abutilon theophrasti), pigweed (Amaranthus spp.), buttonweed (Borreria spp.), oilseed rape, canola, indian mustard, etc. (Brassica spp.), commelina (Commelina spp.), filaree (Erodium spp.), sunflower (Helianthus spp.), morningglory (Ipomoea spp.), kochia (Kochia scoparia), mallow (Malva spp.), wild buckwheat, smartweed, etc. (Polygonum spp.), purslane (Portulaca spp.), russian thistle (Salsola spp.), sida (Sida spp.), wild mustard (Sinapis arvensis), cocklebur (Xanthium spp.), wild oat (Avena fatua), carpetgrass (Axonopus spp.), downy brome (Bromus tectorum), crabgrass (Digitaria spp.), barnyardgrass (Echinochloa crus-galli), goosegrass (Eleusine indica), annual ryegrass (Lolium multiflorum), rice (Oryza sativa), ottochloa (Ottochloa nodosa), bahiagrass (Paspalum notatum), canarygrass (Phalaris spp.), foxtail (Setania spp.), wheat (Triticum aestivum), corn (Zea mays), mugwort (Artemisia spp.), milkweed (Asclepias spp.), canada thistle (Cirsium arvense), field bindweed (Convolvulus arvensis), kudzu (Pueraria spp.), brachiaria (Brachiaria spp.), bermudagrass (Cynodon dactylon), yellow nutsedge (Cyperus esculentus), purple nutsedge (C. rotundus), quackgrass (Elymus repens), lalang (Imperata cylindrica), perennial ryegrass (Lolium perenne), guineagrass (Panicum maximum), dallisgrass (Paspalum dilatatum), reed (Phragmites spp.), johnsongrass (Sorghum halepense), cattail (Typha spp.), horsetail (Equisetum spp.), bracken (Pteridium aquilinum), blackberry (Rubus spp.) and gorse (Ulex europaeus).
Crop and other cultivated species may also be contacted with a composition of the invention. Non-limiting examples of cultivated plants include, but are not limited to, species from the genera Fragaria, Lotus, Medicago, Onobrychis, Trifolium, Trigonella, Vigna, Citrus, Linum, Geranium, Manihot, Daucus, Arabidopsis, Brassica, Raphanus, Sinapis, Atropa, Capsicum, Datura, Hyoscyamus, Lycopersicon, Nicotiana, Helianthus, Lactuca, Bromus, Asparagus, Antirrhinum, Hemerocallis, Nemesia, Pelargonium, Panicum, Pennisetum, Ranunculus, Senecio, Salpiglossis, Cucumis, Bromelia, Glycine, Lolium, Zea, Triticum, Sorghum, Ipomoea, Passifora, Cyclamen, Malus, Prumus, Rosa, Rubus, Populus, Santalum, Allium, Lilium, Narcissus, Ananas, Arachis, Phaseolus, Pisum, Oryza, Hordeum, Gossypium.
A common class of plants exploited in agriculture are vegetable crops, including artichokes, kohlrabi, arugula, leeks, asparagus, lettuce (e.g., head, leaf, romaine), bok choy, malanga, broccoli, melons (e.g., muskmelon, watermelon, crenshaw, honeydew, cantaloupe), brussels sprouts, cabbage, cardoni, carrots, napa, cauliflower, okra, onions, celery, parsley, chick peas, parsnips, chicory, Chinese cabbage, peppers, collards, potatoes, cucumber plants (marrows, cucumbers), pumpkins, cucurbits, radishes, dry bulb onions, rutabaga, eggplant, salsify, escarole, shallots, endive, garlic, spinach, green onions, squash, greens, beet (sugar beet and fodder beet), sweet potatoes, swiss-chard, horseradish, tomatoes, kale, turnips, and spices.
Other types of plants frequently finding commercial use include fruit and vine crops such as apples, apricots, cherries, nectarines, peaches, pears, plums, prunes, quince almonds, chestnuts, filberts, pecans, pistachios, walnuts, citrus, blueberries, boysenberries, cranberries, currants, loganberries, raspberries, strawberries, blackberries, grapes, avocados, bananas, kiwi, persimmons, pomegranate, pineapple, tropical fruits, pomes, melon, mango, papaya, and lychee.
Many of the most widely grown plants are field crop plants such as evening primrose, meadow foam, corn (field, sweet, popcorn), hops, jojoba, peanuts, rice, safflower, small grains (barley, oats, rye, wheat, etc.), sorghum, tobacco, kapok, leguminous plants (beans, lentils, peas, soybeans), oil plants (rape, mustard, poppy, olives, sunflowers, coconut, castor oil plants, cocoa beans, groundnuts), fiber plants (cotton, flax, hemp, jute), lauraceae (cinnamon, camphor), or plants such as coffee, sugarcane, tea, and natural rubber plants.
Another economically important group of plants are ornamental plants. Examples of commonly grown ornamental plants include alstroemeria (e.g., Alstoemeria brasiliensis), aster, azalea (e.g., Rhododendron sp.), begonias (e.g., Begonia sp.), bellflower, bouganvillea, cactus (e.g., Cactaceae schlumbergera truncata), camellia, carnation (e.g., Dianthus caryophyllus), chrysanthemums (e.g., Chrysanthemum sp.), clematis (e.g., Clematis sp.), cockscomb, columbine, cyclamen (e.g., Cyclamen sp.), daffodils (e.g., Narcissus sp.), false cypress, freesia (e.g., Freesia refracta), geraniums, gerberas, gladiolus (e.g., Gladiolus sp.), holly, hybiscus (e.g., Hibiscus rosasanensis), hydrangea (e.g., Macrophylla hydrangea), juniper, lilies (e.g., Lilium sp.), magnolia, miniroses, orchids (e.g., members of the family Orchidaceae), petunias (e.g., Petunia hybrida), poinsettia (e.g., Euphorbia pulcherima), primroses, rhododendron, roses (e.g., Rosa sp.), snapdragons (e.g., Antirrhinum sp.), shrubs, trees such as forest (broad-leaved trees and evergreens, such as conifers) and tulips (e.g., Tulipa sp.).
III. Antibiotics
Another embodiment of the invention concerns methods and compositions for the contemporaneous administration of ectophosphatase inhibitors and antibiotics. Antibiotics are any chemical of natural or synthetic origin that kill or inhibit the growth of other types cells. Many clinically-useful antibiotics are produced by microorganisms. Antibiotics are typically low molecular-weight (non-protein) molecules produced as secondary metabolites, mainly by microorganisms that live in the soil. Most of these microorganisms form some type of a spore or other dormant cell, and there is thought to be some relationship (besides temporal) between antibiotic production and the processes of sporulation. Among molds, the notable antibiotic producers are Penicillium and Cephalosporium, which are the main source of the beta-lactam antibiotics (penicillin and its relatives). In the Bacteria, the Actinomycetes, notably Streptomyces species, produce a variety of types of antibiotics including the aminoglycosides (e.g. streptomycin), macrolides (e.g. erythromycin), and the tetracyclines. Endospore-forming Bacillus species produce polypeptide antibiotics such as polymyxin and bacitracin. The table below (Table 1) is a summary of the classes of antibiotics and their properties including their biological sources.
As set forth in Table 2, certain aspects of the invention concern compositions comprising an ectophosphatase inhibitor and an antibiotic of a class selected from the group consisting of: beta-lactams (penicillins and cephalosporins); semisynthetic penicillin; clavulanic Acid; monobactams; carboxypenems; aminoglycosides; glycopeptides; lincomycins; macrolides; polypeptides; chloramphenicol; polyenes; rifamycins; tetracyclines; and semisynthetic tetracycline. Any ectophosphatase inhibitor may be used in conjuntion with these classes of antibiotics. In certain embodiments of the invention, the ectophosphatase inhibitor is selected from the group consisting of the compounds of formulas I-XX.
TABLE 2
|
|
Classes of antibiotics and their properties
Spectrum (effective
Chemical classExamplesBiological sourceagainst)Mode of action
|
Beta-lactamsPenicillin G,Penicillium notatum andGram-positive bacteriaInhibits steps in cell wall
(penicillins andCephalothinCephalosporium species(peptidoglycan) synthesis and
cephalosporins)murein assembly
SemisyntheticAmpicillin,Gram-positive and Gram-Inhibits steps in cell wall
penicillinAmoxycillinnegative bacteria(peptidoglycan) synthesis and
murein assembly
Clavulanic AcidClavamox isStreptomyces clavuligerusGram-positive and Gram-Suicide inhibitor of beta-lactamases
clavulanic acid plusnegative bacteria
amoxycillin
MonobactamsAztreonamChromobacter violaceumGram-positive and Gram-Inhibits steps in cell wall
negative bacteria(peptidoglycan) synthesis and
murein assembly
CarboxypenemsImipenemStreptomyces cattleyaGram-positive and Gram-Inhibits steps in cell wall
negative bacteria(peptidoglycan) synthesis and
murein assembly
AminoglycosidesStreptomycinStreptomyces griseusGram-positive and Gram-Inhibit translation (protein synthesis)
negative bacteria
GentamicinMicromonospora speciesGram-positive and Gram-Inhibit translation (protein synthesis)
negative bacteria esp.
Pseudomonas
GlycopeptidesVancomycinStreptomyces orientalesGram-positive bacteria,Inhibits steps in murein
esp. Staphylococcus(peptidoglycan) biosynthesis and
aureusassembly
LincomycinsClindamycinStreptomyces lincolnensisGram-positive and Gram-Inhibits translation (protein
negative bacteria esp.synthesis)
anaerobic Bacteroides
MacrolidesErythromycinStreptomyces erythreusGram-positive bacteria,Inhibits translation (protein
Gram-negative bacteriasynthesis)
not enterics,
Neisseria, Legionella,
Mycoplasma
PolypeptidesPolymyxinBacillus polymyxaGram-negative bacteriaDamages cytoplasmic membranes
BacitracinBacillus subtilisGram-positive bacteriaInhibits steps in murein
(peptidoglycan) biosynthesis and
assembly
PolyenesAmphotericinStreptomyces nodosusFungiInactivate membranes containing
sterols
NystatinStreptomyces nourseiFungi (Candida)Inactivate membranes containing
sterols
RifamycinsRifampicinStreptomyces mediterraneiGram-positive and Gram-Inhibits transcription (eubacterial
negative bacteria,RNA polymerase)
Mycobacterium
tuberculosis
TetracyclinesTetracyclineStreptomyces speciesGram-positive and Gram-Inhibit translation (protein synthesis)
negative bacteria,
Rickettsias
SemisyntheticDoxycyclineGram-positive and Gram-Inhibit translation (protein synthesis)
tetracyclinenegative bacteria,
Rickettsias Ehrlichia,
Borellia
ChloramphenicolChloramphenicolStreptomyces venezuelaeGram-positive and Gram-Inhibits translation (protein
negative bacteriasynthesis)
|
A. Antimicrobial Agents Used in the Treatment of Infectious Disease
An important property of a clinically-useful antimicrobial agent, especially from the patient's point of view, is its selective toxicity, i.e., that the agent acts in some way that inhibits or kills bacterial pathogens but has little or no toxic effect on the animal taking the drug. This implies that the biochemical processes in the bacteria are in some way different from those in the animal cells, and that the advantage of this difference can be taken in chemotherapy. Antibiotics may have a cidal (killing) effect or a static (inhibitory) effect on a range of microbes. The range of bacteria or other microorganisms that are affected by a certain antibiotic are is expressed as its spectrum of action. Antibiotics effective against prokaryotes which kill or inhibit a wide range of Gram-positive and Gram-negative bacteria are said to be broad spectrum. If effective mainly against Gram-positive or Gram-negative bacteria, they are narrow spectrum. If effective against a single organism or disease, they are referred to as limited spectrum. In accordance with the invention, certain adverse effects of antibiotics may be minimized by use of en ectophosphatase inhibitor in combination with the antibiotic, thereby allowing use of lower doses of antibiotics.
B. Kinds of Antimicrobial Agents and Their Primary Modes of Action
In one embodiment of the invention, ectophosphatase inhibitors are used in conjunction with cell wall synthesis inhibitors. Cell wall synthesis inhibitors generally inhibit some step in the synthesis of bacterial peptidoglycan. Generally they exert their selective toxicity against eubacteria because human cells lack cell walls.
Beta lactam antibiotics contain a 4-membered beta lactam ring. They are the products of two groups of fungi, Penicillium and Cephalosporium molds, and are correspondingly represented by the penicillins and cephalosporins. The beta lactam antibiotics inhibit the last step in peptidoglycan synthesis, the final cross-linking between peptide side chains, mediated by bacterial carboxypeptidase and transpeptidase enzymes. Beta lactam antibiotics are normally bactericidal and require that cells be actively growing in order to exert their toxicity.
Natural penicillins, such as Penicillin G or Penicillin V, are produced by fermentation of Penicillium chrysogenum. They are effective against streptococcus, gonococcus and staphylococcus, except where resistance has developed. They are considered narrow spectrum since they are not effective against Gram-negative rods.
Semisynthetic penicillins date to 1959. Mold produces a main part of the penicillin molecule (6-aminopenicillanic acid) which can be modified chemically by the addition of side chains. Many of these compounds have been developed to have distinct benefits or advantages over penicillin G, such as increased spectrum of activity (effectiveness against Gram-negative rods), resistance to penicillinase, effectiveness when administered orally, etc. Amoxycillin and Ampicillin have broadened spectra against Gram-negatives and are effective orally; Methicillin is penicillinase-resistant.
Clavulanic acid is a chemical sometimes added to a semisynthetic penicillin preparation. Thus, amoxycillin plus clavulanate is clavamox or augmentin. The clavulanate is not an antimicrobial agent. It inhibits beta lactamase enzymes and has given extended life to penicillinase-sensitive beta lactams.
Although nontoxic, penicillins occasionally cause death when administered to persons who are allergic to them. In the U.S. there are 300-500 deaths annually due to penicillin allergy. In allergic individuals the beta lactam molecule attaches to a serum protein which initiates an IgE-mediated inflammatory response.
Cephalolsporins are beta lactam antibiotics with a similar mode of action to penicillins that are produced by species of Cephalosporium. The have a low toxicity and a somewhat broader spectrum than natural penicillins. They are often used as penicillin substitutes, against Gram-negative bacteria, and in surgical prophylaxis. They are subject to degradation by some bacterial beta-lactamases, but they tend to be resistant to beta-lactamases from S. aureus.
Bacitracin is a polypeptide antibiotic produced by Bacillus species. It prevents cell wall growth by inhibiting the release of the muropeptide subunits of peptidoglycan from the lipid carrier molecule that carries the subunit to the outside of the membrane Teichoic acid synthesis, which requires the same carrier, is also inhibited. Bacitracin has a high toxicity which precludes its systemic use. It is present in many topical antibiotic preparations, and since it is not absorbed by the gut, it is given to “sterilize” the bowel prior to surgery.
Cell membrane inhibitors disorganize the structure or inhibit the function of bacterial membranes. The integrity of the cytoplasmic and outer membranes is vital to bacteria, and compounds that disorganize the membranes rapidly kill the cells. However, due to the similarities in phospholipids in eubacterial and eukaryotic membranes, this action is rarely specific enough to permit these compounds to be used systemically. The only antibacterial antibiotic of clinical importance that acts by this mechanism is Polymyxin, produced by Bacillus polymyxis. Polymyxin is effective mainly against Gram-negative bacteria and is usually limited to topical usage. Polymyxins bind to membrane phospholipids and thereby interfere with membrane function. Polymyxin is occasionally given for urinary tract infections caused by Pseudomonas that are gentamicin, carbenicillin and tobramycin resistant. The balance between effectiveness and damage to the kidney and other organs is dangerously close, and the drug should only be given under close supervision in the hospital.
In accordance with the invention, ectophosphatase inhibitors may also be contemporaneously administered and formulated in compositions with antibiotics that are protein synthesis inhibitors. Many therapeutically useful antibiotics inhibit some step in the complex process of translation. The attack is at one of the events occurring on the ribosome, rather than the stage of amino acid activation or attachment to a particular tRNA. Most have an affinity or specificity for 70S (as opposed to 80S) ribosomes, and they achieve their selective toxicity in this manner. The most important antibiotics with this mode of action are the tetracyclines, chloramphenicol, the macrolides (e.g. erythromycin) and the aminoglycosides (e.g. streptomycin).
The aminoglycosides are products of Streptomyces species and are represented by streptomycin, kanamycin, tobramycin and gentamicin. These antibiotics exert their activity by binding to bacterial ribosomes and preventing the initiation of protein synthesis. Aminoglycosides have been used against a wide variety of bacterial infections caused by Gram-positive and Gram-negative bacteria. Streptomycin has been used extensively as a primary drug in the treatment of tuberculosis. Gentamicin is active against many strains of Gram-positive and Gram-negative bacteria, including some strains of Pseudomonas aeruginosa. Kanamycin (a complex of three antibiotics, A, B and C) is active at low concentrations against many Gram-positive bacteria, including penicillin-resistant staphylococci. Gentamicin and Tobramycin are mainstays for treatment of Pseudomonas infections. An unfortunate side effect of aminoglycosides has tended to restrict their usage: prolonged use is known to impair kidney function and cause damage to the auditory nerves leading to deafness.
The tetracyclines consist of eight related antibiotics which are all natural products of Streptomyces, although some can now be produced semisynthetically. Tetracycline, chlortetracycline and doxycycline are the best known. The tetracyclines are broad-spectrum antibiotics with a wide range of activity against both Gram-positive and Gram-negative bacteria. The tetracyclines act by blocking the binding of aminoacyl tRNA to the A site on the ribosome. Tetracyclines inhibit protein synthesis on isolated 70S or 80S (eukaryotic) ribosomes, and in both cases, their effect is on the small ribosomal subunit. However, most bacteria possess an active transport system for tetracycline that will allow intracellular accumulation of the antibiotic at concentrations 50 times as great as that in the medium. This greatly enhances its antibacterial effectiveness and accounts for its specificity of action, since an effective concentration cannot be accumulated in animal cells. Thus a blood level of tetracycline which is harmless
The tetracyclines have a remarkably low toxicity and minimal side effects when taken by animals. The combination of their broad spectrum and low toxicity has led to their overuse and misuse by the medical community and the wide-spread development of resistance has reduced their effectiveness. Nonetheless, tetracyclines still have some important uses, such as in the treatment of Lyme disease.
Chloramphenicol has a broad spectrum of activity but it exerts a bacteriostatic effect. It is effective against intracellular parasites such as the rickettsiae. Unfortunately, aplastic anemia, which is dose related develops in a small proportion (1/50,000) of patients. Chloramphenicol was originally discovered and purified from the fermentation of a Streptomyces, but currently it is produced entirely by chemical synthesis. Chloramphenicol inhibits the bacterial enzyme peptidyl transferase thereby preventing the growth of the polypeptide chain during protein synthesis.
Chloramphenicol is entirely selective for 70S ribosomes and does not affect 80S ribosomes. Its unfortunate toxicity towards the small proportion of patients who receive it is in no way related to its effect on bacterial protein synthesis. However, since mitochondria probably originated from prokaryotic cells and have 70S ribosomes, they are subject to inhibition by some of the protein synthesis inhibitors including chloroamphenicol. This likely explains the toxicity of chloramphenicol. The eukaryotic cells most likely to be inhibited by chloramphenicol are those undergoing rapid multiplication, thereby rapidly synthesizing mitochondria. Such cells include the blood forming cells of the bone marrow, the inhibition of which could present as aplastic anemia. Chloramphenicol was once a highly prescribed antibiotic and a number of deaths from anemia occurred before its use was curtailed. Now it is seldom used in human medicine except in life-threatening situations (e.g. typhoid fever).
The Macrolides are a family of antibiotics whose structures contain large lactone rings linked through glycoside bonds with amino sugars. The most important members of the group are erythromycin and oleandomycin. Erythromycin is active against most Gram-positive bacteria, Neisseria, Legionella and Haemophilus, but not against the Enterobacteriaceae. Macrolides inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit. Binding inhibits elongation of the protein by peptidyl transferase or prevents translocation of the ribosome or both. Macrolides are bacteriostatic for most bacteria but are cidal for a few Gram-positive bacteria.
In further embodiments of the invention, ectophosphatase inhibitors may be contemporaneously administered and formulated in compositions with antibiotics that affect nucleic acids, including chemotherapeutic agents that affect the synthesis of DNA or RNA, or can bind to DNA or RNA so that their messages cannot be read. In either case, this can block the growth of cells. The majority of these drugs are unselective, however, and affect animal cells and bacterial cells alike and therefore have no therapeutic application. Two nucleic acid synthesis inhibitors which have selective activity against prokaryotes and some medical utility are nalidixic acid and rifamycins.
Nalidixic acid is a synthetic chemotherapeutic agent which has activity mainly against Gram-negative bacteria. Nalidixic acid belongs to a group of compounds called quinolones. Nalidixic acid is a bactericidal agent that binds to the DNA gyrase enzyme (topoisomerase) which is essential for DNA replication and allows supercoils to be relaxed and reformed. Binding of the drug inhibits DNA gyrase activity.
Some quinolones penetrate macrophages and neutrophils better than most antibiotics and are thus useful in treatment of infections caused by intracellular parasites. However, the main use of nalidixic acid is in treatment of lower urinary tract infections (UTI). The compound is unusual in that it is effective against several types of Gram-negative bacteria such as E. coli, Enterobacter aerogentes, K. pneumoniae and Proteus species which are common causes of UTI. It is not usually effective against Pseudomonas aeruginosa, and Gram-positive bacteria are resistant.
The rifamycins are also the products of Streptomyces. Rifampicin is a semisynthetic derivative of rifamycin that is active against Gram-positive bacteria (including Mycobacterium tuberculosis) and some Gram-negative bacteria. Rifampicin acts quite specifically on eubacterial RNA polymerase and is inactive towards RNA polymerase from animal cells or towards DNA polymerase. The antibiotic binds to the beta subunit of the polymerase and apparently blocks the entry of the first nucleotide which is necessary to activate the polymerase, thereby blocking mRNA synthesis. It has been found to have greater bactericidal effect against M. tuberculosis than other anti-tuberculosis drugs, and it has largely replaced isoniazid as one of the front-line drugs used to treat the disease, especially when isoniazid resistance is indicated. It is effective orally and penetrates well into the cerebrospinal fluid and is therefore useful for treatment of tuberculosis meningitis and meningitis caused by Neisseria meningitidis.
In accordance with the invention, ectophosphatase inhibitors may also be administered with competitive inhibitors, including mostly all synthetic chemotherapeutic agents. Most are “growth factor analogs” which are structurally similar to a bacterial growth factor but which do not fulfill its metabolic function in the cell. Some are bacteriostatic and some are bactericidal.
Sulfonamides were originally introduced as chemotherapeutic agents, one of which, prontosil, had the effect of curing mice with infections caused by beta-hemolytic streptococci. Chemical modifications of the compound sulfanilamide gave compounds with even higher and broader antibacterial activity. The resulting sulfonamides have broadly similar antibacterial activity, but differ widely in their pharmacological actions. Bacteria which are almost always sensitive to the sulfonamides include Streptococcus pneumoniae, beta-hemolytic streptococci and E. coli. The sulfonamides have been extremely useful in the treatment of uncomplicated UTI caused by E. coli, and in the treatment of meningococcal meningitis, because they cross the blood-brain barrier.
The sulfonamides (e.g. Gantrisin) and Trimethoprim are inhibitors of the bacterial enzymes required for the synthesis of tetrahydofolic acid (THF), the vitamin form of folic acid essential for 1-carbon transfer reactions. Sulfonamides are structurally similar to para aminobenzoic acid (PABA), the substrate for the first enzyme in the THF pathway, and they competitively inhibit that step. Trimethoprim is structurally similar to dihydrofolate (DHF) and competitively inhibits the second step in THF synthesis mediated by the DHF reductase. Animal cells do not synthesize their own folic acid but obtain it in a preformed fashion as a vitamin. Since animals do not make folic acid, they are not affected by these drugs, which achieve their selective toxicity for bacteria on this basis.
Three additional synthetic chemotherapeutic agents have been used in the treatment of tuberculosis: isoniazid (INH), paraaminosalicylic acid (PAS), and ethambutol. The usual strategy in the treatment of tuberculosis has been to administer a single antibiotic (historically streptomycin, but now, most commonly, rifampicin is given) in conjunction with INH and ethambutol. Since the tubercle bacillus rapidly develops resistance to the antibiotic, ethambutol and INH are given to prevent outgrowth of a resistant strain. It must also be pointed out that the tubercle bacillus rapidly develops resistance to ethambutol and INH if either drug is used alone. Ethambutol inhibits incorporation of mycolic acids into the mycobacterial cell wall. Isoniazid has been reported to inhibit mycolic acid synthesis in mycobacteria and since it is an analog of pyridoxine (Vitamin B6) it may inhibit pyridoxine catalyzed reactions as well. Isoniazid is activated by a mycobacterial peroxidase enzyme and destroys several targets in the cell. PAS is an anti-folate. PAS was once a primary anti-tuberculosis drug, but now it is a secondary agent, having been largely replaced by ethambutol.
C. Inhibition of Drug Resistance in Microorganisms to Treat Infection
The present invention also relates to methods for inhibiting or ameliorating infection in animals and humans caused by microorganisms. For example, treatment of bacterial and fungal infections may be augmented or effected using inhibitory mechanisms against an ectophosphatase to modify the ATP gradient across biological membranes. The invention is useful in the inhibition or amelioration of a wide range of infections including, but not limited to, gram negative bacterial infection including gram-negative sepsis, gram-negative endotoxin-related hypotension and shock, rabies, cholera, tetanus, lymes disease, tuberculosis, Candida albicans, Chlamydia, etc.
The inhibition or amelioration of the infections may involve the administration of an anti-microbial agent (such as an antibiotic or an antifungal agent) with the concurrent administration of the aforementioned compositions. Additionally, inhibitors of ectophosphatases or ABC transporters may be administered via a physiologically acceptable carrier as described above. In one embodiment of the invention, the inhibitor of ectophosphatase is selected from the compounds represented by formulas I-XX.
Certain aspects of the current invention thus concern the inhibition of cell growth by contacting a cell with an inhibitor of an ectophosphatase with contemporaneous administration of other agents capable of inhibiting cell growth or killing the cell. In this manner, therapeutic benefit may be obtained for the treatment of bacterial infections. Examples of types of bacteria that could be inhibited and bacterial infections that could potentially be treated or prevented with the invention, include, but are not limited to, the 83 or more distinct serotypes of pneumococci, streptococci such as S. pyogenes, S. agalactiae, S. equi, S. canis, S. bovis, S. equinus, S. anginosus, S. sanguis, S. salivarius, S. mitis, S. mutans, other viridans streptococci, peptostreptococci, other related species of streptococci, enterococci such as Enterococcus faecalis, Enterococcus faecium, Staphylococci, such as Staphylococcus epidermidis, Staphylococcus aureus, particularly in the nasopharynx, Hemophilus influenzae, pseudomonas species such as Pseudomonas aeruginosa, Pseudomonas pseudomallei, Pseudomonas mallei, brucellas such as Brucella melitensis, Brucella suis, Brucella abortus, Bordetella pertussis, Neisseria meningitidis, Neisseria gonorrhoeae, Moraxella catarrhalis, Corynebacterium diphtheriae, Corynebacterium ulceratis, Corynebacterium pseudotuberculosis, Corynebacterium pseudodiphtheriticum, Corynebacterium urealyticum, Corynebacterium hemolyticum, Corynebacterium equi, etc. Listeria monocytogenes, Nocordia asteroides, Bacteroides species, Actinomycetes species, Treponema pallidum, Leptospirosa species and related organisms. The invention may also find use, for example, against gram negative bacteria such as Klebsiella pneumoniae, Escherichia coli, Proteus, Serratia species, Acinetobacter, Yersinia pestis, Francisella tularensis, Enterobacter species, Bacteriodes and Legionella species and the like.
IV. Chemotherapeutics
A variety of chemotherapeutic agents are suitable for use with the invention and are known to those of skill in the art. In accordance with the invention, therapeutic benefit may be obtained by contemporaneous administration of one or more ectophosphatase inhibitor and one or more such chemotherapeutic agent(s). Co-administration of chemotherapeutics with ectophosphatase inhibitors in accordance with the invention may be used to increase therapeutic effectiveness of a chemotherapeutic and may allow use of lowered doses. Such techniques may further allow treatment of chemotherapy-resistant tumor cells.
As will be understood by those of ordinary skill in the art, the appropriate doses of chemotherapeutic agents will be generally around those already employed in clinical therapies wherein the chemotherapeutics are administered alone or in combination with other chemotherapeutics. By way of example only, agents such as cisplatin, and other DNA alkylating agents may be used with an ectophosphatase inhibitor. Cisplatin has been widely used to treat cancer, with efficacious doses used in clinical applications of 20 mg/m2 for 5 days every three weeks for a total of three courses. Cisplatin is not absorbed orally and must therefore be delivered via injection intravenously, subcutaneously, intratumorally or intraperitoneally.
Further agents for use with ectophosphatase inhibitors in accordance with the invention include, for example, compounds that interfere with DNA replication, mitosis and chromosomal segregation. Such chemotherapeutic compounds include adriamycin, also known as doxorubicin, etoposide, verapamil, podophyllotoxin, and the like. Widely used in a clinical setting for the treatment of neoplasms, these compounds are administered through bolus injections intravenously at doses ranging from 25-75 mg/m2 at 21 day intervals for adriamycin, to 35-50 mg/m2 for etoposide intravenously or double the intravenous dose orally.
Agents that disrupt the synthesis and fidelity of polynucleotide precursors also may be used with ectophosphatase inhibitors. Particularly useful are agents that have undergone extensive testing and are readily available. As such, agents such as 5-fluorouracil (5-FU) are preferentially used by neoplastic tissue, making this agent particularly useful for targeting to neoplastic cells. Although quite toxic, 5-FU is applicable in a wide range of carriers, including topical, with intravenous administration in doses ranging from 3 to 15 mg/kg/day being commonly used.
Exemplary and non-limiting chemotherapeutic agents for use in combination with an ectophosphatase inhibitor in accordance with the invention are listed in Table 3. Accordingly, compositions comprising these agents and one or more ectophosphatase inhibitor(s) form one part of the invention, as do methods for the administration thereof. Each of the agents listed below are exemplary and by no means limiting. In this regard, the skilled artisan is directed to “Remington's Pharmaceutical Sciences” 15th Edition, chapter 33, in particular pages 624-652. Some variation in dosage will necessarily occur depending on the condition of the subject being treated. The person responsible for administration will, in any event, determine the appropriate dose for the individual subject. Moreover, for human administration, preparations should meet sterility, pyrogenicity, general safety and purity standards as required by FDA Office of Biologics standards.
Specifically contemplated by the inventors are compositions comprising and ectophosphatase inhibitor and a chemotherapeutic agent set forth in Table 3, as well as methods comprising the use thereof
TABLE 3
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Chemotherapeutic Agents Useful In Neoplastic Disease
NONPROPRIETARY
TYPE OFNAMES
CLASSAGENT(OTHER NAMES)DISEASE
|
Mechlorethamine (HN2)Hodgkin's disease,
non-Hodgkin's lymphomas
NitrogenCyclophosphamideAcute and chronic
MustardsIfosfamidelymphocytic leukemias,
Hodgkin's disease,
non-Hodgkin's lymphomas,
multiple myeloma,
neuroblastoma, breast, ovary,
lung, Wilms' tumor, cervix,
testis, soft-tissue sarcomas
Melphalan (L-sarcolysin)Multiple myeloma, breast,
ovary
ChlorambucilChronic lymphocytic
leukemia, primary
macroglobulinemia,
Hodgkin's disease,
non-Hodgkin's lymphomas
AlkylatingEthylenimenesHexamethylmelamineOvary
Agentsand
Methylmelamines
ThiotepaBladder, breast, ovary
AlkylBusulfanChronic granulocytic leukemia
Sulfonates
Carmustine (BCNU)Hodgkin's disease,
non-Hodgkin's lymphomas,
primary brain tumors, multiple
myeloma, malignant
melanoma
NitrosoureasLomustine (CCNU)Hodgkin's disease,
non-Hodgkin's lymphomas,
primary brain tumors,
small-cell lung
SemustinePrimary brain tumors,
(methyl-CCNU)stomach, colon
StreptozocinMalignant pancreatic
(streptozotocin)insulinoma, malignant
carcinoid
TriazinesDacarbazine (DTIC;Malignant melanoma,
dimethyltriazenoimidazolecarboxamide)Hodgkin's disease, soft-tissue
sarcomas
AntimetabolitesFolic AcidMethotrexateAcute lymphocytic leukemia,
Analogs(amethopterin)choriocarcinoma, mycosis
fungoides, breast, head and
neck, lung, osteogenic
sarcoma
PyrimidineFluouracilBreast, colon, stomach,
Analogs(5-fluorouracil; 5-FU)pancreas, ovary, head and
Floxuridineneck, urinary bladder,
(fluorode-oxyuridine;premalignant skin lesions
FUdR)(topical)
Antimetabolites,Cytarabine (cytosineAcute granulocytic and acute
continuedarabinoside)lymphocytic leukemias
MercaptopurineAcute lymphocytic, acute
(6-mercaptopurine;granulocytic and chronic
6-MP)granulocytic leukemias
Purine AnalogsThioguanineAcute granulocytic, acute
and Related(6-thioguanine; TG)lymphocytic and chronic
Inhibitorsgranulocytic leukemias
PentostatinHairy cell leukemia, mycosis
(2-deoxycoformycin)fungoides, chronic
lymphocytic leukemia
Vinblastine (VLB)Hodgkin's disease,
non-Hodgkin's lymphomas,
breast, testis
Vinca AlkaloidsVincristineAcute lymphocytic leukemia,
neuroblastoma, Wilms' tumor,
rhabdomyosarcoma,
Hodgkin's disease,
non-Hodgkin's lymphomas,
small-cell lung
EpipodophyllotoxinsEtoposideTestis, small-cell lung and
Tertiposideother lung, breast, Hodgkin's
disease, non-Hodgkin's
lymphomas, acute
granulocytic leukemia,
Kaposi's sarcoma
NaturalDactinomycinChoriocarcinoma, Wilms'
Products(actinomycin D)tumor, rhabdomyosarcoma,
testis, Kaposi's sarcoma
DaunorubicinAcute granulocytic and acute
(daunomycin;lymphocytic leukemias
rubidomycin)
AntibioticsDoxorubicinSoft-tissue, osteogenic and
other sarcomas; Hodgkin's
disease, non-Hodgkin's
lymphomas, acute leukemias,
breast, genitourinary, thyroid,
lung, stomach, neuroblastoma
BleomycinTestis, head and neck, skin,
esophagus, lung and
genitourinary tract; Hodgkin's
disease, non-Hodgkin's
lymphomas
Antibiotics,PlicamycinTestis, malignant
continued(mithramycin)hypercalcemia
NaturalMitomycin (mitomycinStomach, cervix, colon, breast,
Products,C)pancreas, bladder, head and
continuedneck
EnzymesL-AsparaginaseAcute lymphocytic leukemia
BiologicalInterferon alfaHairy cell leukemia., Kaposi's
Responsesarcoma, melanoma,
Modifierscarcinoid, renal cell, ovary,
bladder, non-Hodgkin's
lymphomas, mycosis
fungoides, multiple myeloma,
chronic granulocytic leukemia
PlatinumCisplatin (cis-DDP)Testis, ovary, bladder, head
CoordinationCarboplatinand neck, lung, thyroid,
Complexescervix, endometrium,
neuroblastoma, osteogenic
sarcoma
AnthracenedioneMitoxantroneAcute granulocytic leukemia,
breast
MiscellaneousSubstituted UreaHydroxyureaChronic granulocytic
Agentsleukemia, polycythemia vera,
essental thrombocytosis,
malignant melanoma
MethylProcarbazineHodgkin's disease
Hydrazine(N-methylhydrazine,
DerivativeMIH)
AdrenocorticalMitotane (o, p′-DDD)Adrenal cortex
SuppressantAminoglutethimideBreast
AdrenocorticosteroidsPrednisone (several otherAcute and chronic
equivalent preparationslymphocytic leukemias,
available)non-Hodgkin's lymphomas,
Hodgkin's disease, breast
Hormones andProgestinsHydroxyprogesteroneEndometrium, breast
Antagonistscaproate
Medroxyprogesterone
acetate
Megestrol acetate
EstrogensDiethylstilbestrolBreast, prostate
Ethinyl estradiol (other
preparations available)
AntiestrogenTamoxifenBreast
AndrogensTestosterone propionateBreast
Fluoxymesterone (other
preparations available)
AntiandrogenFlutamideProstate
Gonadotropin-releasingLeuprolideProstate
hormone
analog
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Administration of compositions provided by the invention may be local or systemic, using a suitable physiological carrier. Other compounds which aid in the uptake or stability of these agents, or which have beneficial activity, may also be included in the formulations of the invention. Certain embodiments of the invention thus provide pharmaceutical composition comprising an ectophosphatase inhibitor. The composition may further comprise, in certain embodiments, a cytotoxic agent, including a chemotherapeutic agent set forth herein. For example, by contacting a tumor cell either alone with the ectophosphatase inhibitor or in combination with one or more chemotherapeutic agents, therapeutic benefit may be obtained. Particular benefit may be obtained where a tumor cell is resistant to at least one chemotherapeutic agent. This may enhance the overall anti-tumor activity achieved by therapy, and/or may be used to prevent or combat multi-drug tumor resistance.
V. Assays and Methods for Screening Active Compounds
In one embodiment of the invention, assays are provided for screening compositions comprising combinations of ectophosphatase inhibitors and a selected cytotoxic agent, for example, a herbicide, fungicide, antibiotic, insecticide or chemotherapeutic agent. A number of assay formats are known to those of skill in the art and may be used in this regard. These include assays of biological activities as well as assays of chemical properties. The results of these assays provide important inferences as to the properties of compounds as well as their potential applications in treating human or other mammalian patients for infection and hyperproliferative diseases as well as in various agricultural applications. Assays deemed to be of particular utility in this regard include in vivo and in vitro screens of activity and immunoassays.
(i) Screening for Herbicidal Activity
One aspect of the current invention provides herbicidal compositions having improved herbicidal activity. In accordance with the invention, assays for herbicidal activity may be used to asses the relative efficacy of combinations of ectophosphatase inhibitors and herbicidal agents. Numerous assays formats for analyzing herbicidal activity are known to those of skill in the art and may be used in this regard. A straightforward means for testing activity comprises the serial application of test compositions to plants and/or plant parts, for example, by leaf painting. Plants are otherwise grown under comparable conditions, followed by serial applications of test and control compositions are applied. Control treatments may be used comprising herbicide compositions lacking ectophosphatase inhibitors, thereby identifying the presence of absence of activity as a syngerist. Herbicidal activity is then measured by analysis of the effect of the composition on plant viability.
Commercial herbicide formulations are well known to those of skill in the art and will generally be used in assays. However, it will typically be preferred to dilute herbicidal compositions and/or administer reduced amounts of the compositions such that the relative herbicidal activity of a composition may be quantified. Reductions in the lethality of herbicidal compositions allows the identification of effectiveness between herbicidal compositions. Thus, in particular embodiments of the invention, test and control compositions are administered in rates and/or amounts of from about 90% to about 5% of the commercial application rate for a given herbicide.
Following application of herbicidal test compositions, herbicidal activity and effectiveness is measured. Through comparisons with applications of control compositions, the effectiveness of the compositions may be determined.
Tests may be carried out on whole plants as well as plant parts or cell. For example, plant cells in tissue culture may be screened for herbicidal activity. The preparation of plant tissue-cultures is well known to those of skill in the art.
(ii) In Vivo Assays
The present invention encompasses the use of various animal models. Here, the identity seen between human and mouse provides an excellent opportunity to examine the function of a potential therapeutic agent, for example, an antiinfective or chemotherapeutic administered in combination with an ectophosphatase inhibitor. In the case of chemotherapeutics, one can utilize cancer models in mice that will be highly predictive of cancers in humans and other mammals. These models may employ the orthotopic or systemic administration of tumor cells to mimic primary and/or metastatic cancers. Alternatively, one may induce cancers in animals by providing agents known to be responsible for certain events associated with malignant transformation and/or tumor progression. Similarly, numerous animal models are available for analysis of antinfectives, including insecticides, antibiotics and antifungal agents. In this manner, all that is commonly required is infection of the relevant animal with a target infective agent and analysis of therapeutic benefit relative to prior antiinfective compositions.
Treatment of animals with test compositions will involve the administration of the composition, in an appropriate form, to the animal. Administration will be by any route the could be utilized for clinical or non-clinical purposes, including but not limited to oral, nasal, buccal, rectal, vaginal or topical. Alternatively, administration may be by intratracheal instillation, bronchial instillation, intradermal, subcutaneous, intramuscular, intraperitoneal or intravenous injection. Specifically contemplated are systemic intravenous injection, regional administration via blood or lymph supply and intratumoral injection.
Determining the effectiveness of a compound in vivo may involve a variety of different criteria. Such criteria include, but are not limited to, survival, reduction of tumor burden or mass, arrest or slowing of tumor progression, elimination of tumors, inhibition or prevention of metastasis, increased activity level, improvement in immune effector function and improved food intake. Through comparisons of active agents alone and active agents in combination with ectophosphatase inhibitors, synergistic combinations may be readily confirmed.
(iii) Confirmatory In Vivo and Clinical Studies
It will be understood by those of skill in the art that therapeutic compositions should generally be tested in an in vivo setting prior to use in a human subject. Such pre-clinical testing in animals is routine in the art. To conduct such confirmatory tests, all that is required is an art-accepted animal model of the disease in question, such as an animal bearing a solid tumor or infective agent. Any animal may be used in such a context, such as, e.g., a mouse, rat, guinea pig, hamster, rabbit, dog, chimpanzee, or such like. Studies using small animals such as mice are widely accepted as being predictive of clinical efficacy in humans, and such animal models may thus find use in the context of the present invention as they are readily available and relatively inexpensive, at least in comparison to other experimental animals.
The manner of conducting an experimental animal test will be straightforward to those of ordinary skill in the art. All that is required to conduct such a test is to establish equivalent treatment groups, and to administer the test compounds to one group while various control studies are conducted in parallel on the equivalent animals in the remaining group or groups. One monitors the animals during the course of the study and, ultimately, one sacrifices the animals to analyze the effects of the treatment.
In the context of the treatment of tumors, it is contemplated that effective amounts of chemotherapeutic compositions will be those that generally result in at least about 10% of the cells within a tumor exhibiting cell death or apoptosis. Preferably, at least about 20%, about 30%, about 40%, or about 50%, of the cells at a particular tumor site will be killed. Most preferably, 100% of the cells at a tumor site will be killed.
The extent of cell death in a tumor is assessed relative to the maintenance of healthy tissues in all of the areas of the body. It will be preferable to use doses of chemotherapeutic compositions capable of inducing at least about 60%, about 70%, about 80%, about 85%, about 90%, about 95% up to and including 100% tumor necrosis, so long as the doses used do not result in significant side effects or other untoward reactions in the animal. All such determinations can be readily made and properly assessed by those of ordinary skill in the art. For example, attendants, scientists and physicians can utilize such data from experimental animals in the optimization of appropriate doses for human treatment. In subjects with advanced disease, a certain degree of side effects can be tolerated. However, patients in the early stages of disease can be treated with more moderate doses in order to obtain a significant therapeutic effect in the absence of side effects. The effects observed in such experimental animal studies should preferably be statistically significant over the control levels and should be reproducible from study to study.
Those of ordinary skill in the art will further understand that combinations and doses of the compositions provided by the invention that result in tumor-specific necrosis towards the lower end of the effective ranges may nonetheless still be useful in connection with the present invention. For example, in embodiments where a continued application of the active agents is contemplated, an initial dose that results in only about 10% necrosis will nonetheless be useful, particularly as it is often observed that this initial reduction “primes” the tumor to further destructive assault upon subsequent re-application of the therapy. In any event, even if upwards of about 40% or so tumor inhibition is not ultimately achieved, it will be understood that any induction, of thrombosis and necrosis is nonetheless useful in that it represents an advance over the state of the patients prior to treatments. Still further, it is contemplated that a dose which prevents or decreases the likelihood of either metastasis or de novo carcinogenesis would also be of therapeutic benefit to a patient receiving the treatment.
As discussed above in connection with the in vitro test system, it will naturally be understood that combinations of agents intended for use together should be tested and optimized together. The compositions of the invention can be straightforwardly analyzed in the combinations set forth herein. Analysis of the combined effects of such agents would be determined and assessed according to the guidelines set forth above.
(iv) In Vitro Assays
In one embodiment of the invention, screening of a composition provided by the invention is conducted in vitro to identify those compounds capable of synergizing therapeutic agents, including cytotoxic agents such as antibiotics, fungicides and chemotherapeutic agents, as well as other types of biologically-active agents. In the case of killing of tumor cells, cytotoxicity is generally exhibited by necrosis or apoptosis. Necrosis is a relatively common pathway triggered by external signals. During this process, the integrity of the cellular membrane and cellular compartments is lost. On the other hand, apoptosis, or programmed cell death, is a highly organized process of morphological events that is synchronized by the activation and deactivation of specific genes (Thompson et al., 1992; Wyllie, 1985). In the case of pesticides, the selective cytotoxic action against the infective agent, including an insect, bacterial or fungal pathogen, is typically analyzed.
An efficacious means for in vitro assaying of cytoxicity comprises the systematic exposure of a panel of cells to selected compositions. For example, in the case of cancer, many tumor cell lines are available for implementing assays, including human ovarian, leukemic, breast, prostate, melanoma and renal cancer cells.
In vitro determinations of the efficacy of a compound in killing tumor cells may be achieved, for example, by assays of the expression and induction of various genes involved in cell-cycle arrest (p21, p27; inhibitors of cyclin dependent kinases) and apoptosis (bcl-2, bcl-xL and bax). To carry out this assay, cells are treated with the test compound, lysed, the proteins isolated, and then resolved on SDS-PAGE gels and the gel-bound proteins transferred to nitrocellulose membranes. The membranes are first probed with the primary antibodies (e.g., antibodies to p21, p27, bax, bcl-2 and bcl-x1, etc.) and then detected with diluted horseradish peroxidase conjugated secondary antibodies, and the membrane exposed to ECL detection reagent followed by visualization on ECL-photographic film. Through analysis of the relative proportion of the proteins, estimates may be made regarding the percent of cells in a given stage, for example, the G0/G1 phase, S phase or G2/M phase.
VI. EXAMPLES
The following examples are included to demonstrate preferred embodiments of the invention. It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent techniques discovered by the inventor to function well in the practice of the invention, and thus can be considered to constitute preferred modes for its practice. However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention.
Example 1
Inhibition of Antibiotic Resistant Bacteria with Ectophosphatase Inhibitors
A. Summary of Protocol and Results
The purpose of this study was to evaluate various ectophosphatase inhibitor compounds for any potentiating effect or resistance reversal with methicillin resistant Staphylococcus aureus (MRSA). Two strains of Staphylococcus aureus were obtained from the American Type Culture Collection (ATCC). Those obtained were a previously characterized methicillin resistant strain (# 43300) and a previously characterized methicillin sensitive strain (# 29213) to serve as a control. Strains were received as lyophilized pellets and were rehydrated according to the ATCC Product Information Sheet using Trypticase Soy Broth.
Mueller-Hinton agar plates were prepared containing 1 of 6 inhibitor compounds investigated. The compounds were dissolved in DMSO at concentrations of 20 mg/ml. 25 μl of this stock solution was added to 25 mls of media just prior to cooling to solidification to produce plates containing 20 μg/ml of inhibitor compound. Control plates containing 25 μl DMSO only were also prepared in the same fashion.
For each of the two strains, 5 isolated colonies were picked from overnight culture plates and used to inoculate a 0.85% NaCl solution. The turbidity of each culture was adjusted using 0.85% NaCl until the turbidity of each matched a 0.5 McFarland turbidity standard. Each strain was swabbed onto control plates. The MRSA strain was swabbed also onto the inhibitor plates. Plates were allowed to dry for 5 minutes. A disk containing 5 μg of methicillin (obtained for the purpose of susceptibility testing from Bioanalyse Co., Ltd.) was placed onto the surface of all plates. Plates were incubated at 37° C.
Plates were read after 24 hours. It was noticed at this time that one plate, containing inhibitor compound NGXT1914 (Formula XV), was clear—there was no bacterial growth at all. All other plates had confluent growth except at the zone of inhibition of the methicillin disk.
Protocols for the studies were according to NCCLS guidelines (M2-A7, M100-S11) for antimicrobial susceptibility testing. Methodology for the serum bactericidal test was according to (Tentative Guideline) NCCLS M21-T, 1992. Methods for determining bactericidal activity of antimicrobial agents was according to (Tentative Guideline) NCCLS M26-T.1992. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. 3rd ed. NCCLS M7-A3.1993. Protocols for evaluating dehydrated Mueller-Hinton agar were according to NCCLS M6-A, 1996. Performance standards for antimicrobial susceptibility testing were according to NCCLS M100-S8, 1998. The screening test for Oxacillin-resistant Staphylococci was according to NCCLS M7-A4. Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals was according to (Approved Standard) NCCLS M31-A. Performance standards for antimicrobial susceptibility testing were according to NCCLS M100-S8.1998. Screening test for Oxacillin-resistant Staphylococci was according to NCCLS M7-A4 Susceptibility test panels.
B. Confirmation of Results
In order to ascertain whether the result with inhibitor NGXT1914 was artifactual, both MRSA and MSSA were tested on Mueller-Hinton agar plates containing varying concentrations of NGXT1914. First, plates were prepared as above with the following concentrations of inhibitor compound: 0 μg/ml (DMSO controls), 1 μg/ml, 5 μg/ml, 10 μg/ml, and 25 μg/ml. Inhibitor concentrations were prepared such that all plates contained 25 μl total DMSO. For each of the two strains, 5 isolated colonies were picked from fresh overnight culture plates and used to inoculate a 0.85% NaCl solution. The turbidity of each culture was adjusted using 0.85% NaCl until the turbidity of each matched a 0.5 McFarland turbidity standard. Both strains were each swabbed onto both control and inhibitor plates. Plates were allowed to dry for 5 minutes and were placed into the incubator. Plates were read after 24 hours (Dec. 7, 2001). The results were as follows:
|
|
Concentration
(μg/ml NGXT1914)Result
|
25 μg/mlNo growth at all for either strain
10 μg/mlNo growth at all for MRSA strain. Some
small isolated colonies on the MSSA plate.
5 μg/mlOnly a few small colonies on the MRSA
plate. Confluent growth on the MSSA
plate.
1 μg/mlConfluent growth on both plates.
ControlsConfluent growth on both plates.
|
C. Conclusions
Inhibitor NGXT 1914 inhibits growth of both resistant and sensitive Staph strains, however it is more effective against the methicillin resistant strain. This compound was tested with other cell types (mammalian cell lines, plants (Arabidopsis thaliana) yeast, Pseudomonas aeruginosa) and has not inhibited growth of any cell line or organism at the concentrations tested. Since NGXT1914 is an ectophosphatase inhibitor, it is possible that Staph, particularly the MRSA, is dependent on a phosphatase that is an ideal substrate for NGXT1914. The results obtained indicated that NGXT1914 was more effective against MRSA versus MSSA than previously identified compounds.
Example 2
Inhibition of Chemotherapy-Resistant Tumor Cells with an Ectophosphatase Inhibitor
In order to determine the effect of ectophosphatase inhibitors on tumor cells resistant to a chemotherapeutic agent, 2 breast cancer tumor cell lines were tested, a vinblastine resistant line (SW-13Vb003) and its vinblastine sensitive parent line, SW-13. A standard 4 day incubation at 37° C. and 5% CO2 was used. IC50 tests (NTT) were done using standard methodology in 96 well plate format with inhibitor concentrations ranging from 0-90 μg/ml (DMEM media). Results showed that 3 of the inhibitor compounds tested, NGXT194 (Formula VI), NGXT196 (Formula VIII), and NGXT1915 (Formula X), produced lower IC50 values with the resistant cell line than with the sensitive line. For NGXT194, SW-13 was sensitive at 20 μg/ml, whereas the vinblastine resistant line SW-13Vb003 was sensitive at 10 μg/ml. For NGXT196, SW-13 was sensitive at 30 μg/ml, whereas the vinblastine resistant line SW-13Vb003 was sensitive at 10 μg/ml. For NGXT1915, SW-13 was sensitive at 50 μg/ml, whereas the vinblastine resistant line SW-13Vb003 was sensitive at 20 μg/ml.
Based on the inventors previous findings concerning the role of ectophosphatases in drug resistance, it seems likely that many resistant cells have upregulated phosphatases and that inhibiting a phosphatase critical to maintaining these cells could result in cell death. One hypothesis is that once these phosphatase enzymes are upregulated or are used in drug resistance their function becomes one that is vital to the cell. Since this phenomenon has been seen now in a bacterial resistance model it might be expected that the ectophosphatase inhibiting compounds could preferentially kill other types of resistant cells or act as biocides to certain cells.
Example 3
Over-Expression of Ectophosphatase does not Increase the Cellular Uptake of Adenosine
A. Materials and Methods
Transgenic Plant Construction: psNTP9 (Pisum Sativum apyrase, GenBank accession #Z32743) was subcloned as a Sall to Xbal fragment into pKYLX71 (Schardl et al, 1987, supra.). This plasmid was transformed into A. tumefaciens GV3101 [pMP90] pKYLX71 (Koncz and Shell, 1986), which was used to infect root call from Ws ecotype Arabidopsis thaliana under kanamycin selection (Valvekens et al., 1992). Four individual lines, obtained from separate calli, were propagated to the third generation (T3).
Subcellular Apyrase Distribution in Pea: Etiolated pea plumules served as the tissue source for nuclei and cytoplasm isolation as described by Chen and Roux (Plant Physiol. 81:609-612 (1986)). Plasma membrane was prepared from 30 g of pea root tissue (Zhu Mei Jun and Chen Jia; 1995, Acta Botanica Sinica 37:942-949). Western analysis was performed on 15-30 pg of protein from cytoplasm, plasma membrane and nuclei using a polyclonal anti-apyrase antibody raised against the purified pea protein (Tong et al., 1993). To determine the orientation of the pea apyrase in the pea plasma membrane, outside-out vesicles were prepared and the accessibility of the enzyme was determined by selective trypsin proteolysis, or membrane shaving, followed by activity assays and western blotting.
Phosphate uptake experiments and growth assays: In all experiments the growth media did not contain sugar, and plants were grown in sterile culture at 22° C. under 150-200 pE of continuous light. Unless otherwise noted, a standard 0.8% agar medium (Becton Dickenson, Cockeysville, Md.) containing 100 μM phosphate was used for uptake assays (Somerville et al., 1982). Plants used for the phosphate uptake experiments were grown singly in 1 ml of the standard agar medium for 15 days prior to the experiment. On the day of the experiment, 10 μCi32P was applied to the side of the culture dish and allowed to diffuse through the agar. The lids of 95 mm×15 mm tissue' culture dishes (Fisher, Pittsburgh, Pa.) were removed to facilitate transpiration.
After 18 hours, the plants were removed from the medium. The aerial portions of the plant not in contact with the agar were weighed and counted by liquid scintillation. For each plant the entire root system was carefully pulled from the agar and washed in ice cold water prior to scintillation counting. To measure the transport of the products of ATP hydrolysis by the transgenic plants overexpressing apyrase and by wild-type plants, [2,83H]ATP, [α32P]ATP, and [γ32P]ATP (Amersham) were fed to 15-day-old plants in separate treatments. All treatments were analyzed for significance in a T-test (n>46 for all groups, *P<0.05, error bars=s.e.m.).
B. Results
Detection of the pea apyrase in nuclei and in purified plasma membrane: By immunoblot assay, the pea apyrase was found to be associated with nuclei and with purified plasma membranes but not with the cytoplasm (FIG. 1A). The contents of the lanes in FIG. 1A are as follows: Lane 1, cytoplasm; Lane 2, purified plasma membrane; Lane 3, purified nuclei; and Lane 4, pre-immune control of nuclei. Protease treatment destroyed both apyrase activity and antigenicity in outside-out plasma membrane vesicles. After trypsin treatment, the exterior face of the vesicle showed 30% of the ectophosphatase activity of the untreated sample. Endo-phosphatase activities were retained after trypsin treatment, indicating that the digest occurred exclusively on the exterior face of the membrane. These data indicated that the ectoapyrase was in fact being expressed in the extracellular matrix (ECM).
Enhanced Growth of Plants Over-Expressing Apyrase: Three of the four transgenic plant lines constitutively expressed psNTP9 under the control of the cauliflower mosaic virus 35S promoter and over an 18 hour period showed two to five times as much phosphate accumulation in shoots as wild type (FIG. 1B); Top, the total phosphate accumulated in the shoots of three independent transformants in an 18 hour 32 p uptake assay at 2 mM phosphate; Bottom, a corresponding immunoblot performed on equal amounts of protein isolated from the ECM of three week-old wild-type Arabidopsis thaliana and the psNTP9 transgenics. Apyrase expressing plants also showed four times as much phosphatase activity in the extracellular matrix as the wild-type (FIG. 1 C). (Note, OE 1 in the FIG. stands for over-expression 1 transgenic line).
Transgenic plants preferentially transport the gamma phosphate of ATP: In order to address whether over-expression of ectoapyrase was stimulating the adenosine salvage pathway, the intracellular uptake of adenosine was measured both in the presence and absence of the overexpression of apyrase. The inability of apyrase to translocate either extracellular AMP or adenosine was demonstrated by the low level of radiolabel accumulated in the transgenic plants fed [2,83H]ATP and [a32P]ATP (FIG. 2). The complete dephosphorylation of [2,83H]ATP would result in a radiolabelled adenosine molecule while the complete dephosphorylation of [a32P]ATP would result in a non-labeled adenosine label. FIG. 2A illustrates that plants overexpressing apyrase did not translocate radiolabelled adenosine (or byproducts of the dephosphorylation of [2,83H]ATP) any more efficiently than plants not overexpressing apyrase (wild-type plants). FIG. 2B illustrates that plants overexpressing apyrase did not translocate AMP (or the byproducts of the dephosphorylated [a32P]ATP) any more efficiently than wildtype plants. In comparison, feeding experiments where the y phosphate was labeled, the transgenics accumulated three times the amount of labeled phosphate as the wild-type (FIG. 2C). These data show that the over-expression of apyrase does not induce an increase in the uptake of adenosine and therefore its over-expression does not act to stimulate the adenosine salvage pathway.
Example 4
EctoPhosphatase is Involved in Drug Resistance in Yeast and Plants
A. Materials and Methods
Expression of AtPGP-1 in yeast: The AtPGP-1 cDNA (Arabidopsis thaliana MDR gene, accession #X61370) was subcloned into pVT101 downstream of the ADH promoter to create the AtPGP-1/pVT101 construct. AtPGP-1/pVT101 and pVT101 were transformed into Saccharomyces cerevisiae INVSCI (genotype: MATa, his3-Δ1, leu2, trpl-289, ura3-52) and YMR4 (genotype: MATαhis3-11,15, leu2-3, 112ura3Δ5, can Res pho5, 3::ura3A1) by a PEG lithium acetate procedure (Eble, 1992) and selected on uracil dropout medium.
Yeast Growth: Yeast were grown at 30° C. under conditions of constant selection for uracil auxotrophy. YNB (Bio101, Vista, Calif.) supplemented with CSM (uracil dropout) and 2% glucose was used to grow strains having pVT101 constructs. Cycloheximide (Sigma Chemical, St. Louis, Mo.) was added to liquid media or spread on solid media to achieve a final concentration of 500 ng/ml. Nigencm (Sigma Chemical, St. Louis, Mo.) was added to liquid media or spread on solid media to achieve a final concentration of 25 μg/ml. Yeast strains used in cycloheximide selection assays were always propagated in the presence of the cycloheximide on plates and then streaked onto new plates containing drug or no drug, such that induced resistance existed in each strain at the time of the start of the assay. For selection assays on plates, single colonies were streaked; for selection in liquid media 0.01 ml of saturated culture was added to fresh media containing the drug. The plates shown in figures were grown for 3-5 days before photographs were taken. Yeast selection assays in liquid media were quantitated by turbidity as measured by absorbance at OD600.
Expression of apyrase and AtPGP-1 in plants: The expression of apyrase in plants is as described above in Example 3. Similar methods were employed to express AtPGP-1 in Arabidopsis thaliana plants with the following modifications. The AtPGP-1 coding region was subcloned into a pBIN vector lacking the GUS gene as described in Sidler et al. (1998). This plasmid was then transformed into A. tumefaciens as described above, which was used to infect root calli to produce transgenic plants expressing AtPGP-1.
Plant growth: Arabidopsis thaliana seeds were sown in a solid germination media containing MS salt, 2% sucrose, 0.8% agar, and vitamins (Valvekens et al., 1992). For selection assays, cycloheximide was spread on the media to achieve a final concentration of 250 ng/ml. Plant growth was measured by germination percentage after 6-30 days.
B. Results
Effect of over-expression of AtPGP-1 in yeast: When a yeast mutant, YNIR4, which is deficient in two major extracellular phosphatases and tends to accumulate ATP extracellularly, was grown in a potent cellular toxin, cycloheximide, it did not grow whereas a wild-type yeast strain, INVSCI, did grow in the presence of cycloheximide (FIG. 3A). Surprisingly, expression of the plant multidrug resistance (MDR) gene, AtPGP-1, enabled the yeast mutant to grow in the toxin (FIG. 3B and FIG. 5A). The presence of AtPGP-1 in the wild-type yeast did not have any effect when grown in the presence of cycloheximide (FIG. 3B). The same result was obtained when the yeast strains were cultured in nigericin (FIG. 3C, 3D, FIG. 5B, 5C). In FIGS. 3C and 3D, starting from the top of the dish clockwise, the cells are as follows: INVSCI (wild-type) overexpressing AtPGP-1, YNM4 containing the vector alone, YMR4 overexpressing AtPGP-1, and INVSCI containing the vector alone. When grown without drug, all the cells grow (FIG. 3C). However, when grown in drug, only the YMR4 containing vector alone shows reduced growth. The survival of the AtPGP-1 transformed strains was due to the ability of the NIDR1 channel to efflux the toxin, hence lowering the actual cellular concentration of the poison cycloheximide. The sensitivity of the untransformed mutant to the drug is likely due to a loss of the ATP gradient below a point at which endogenous transporters, similar to AtPGP-1 can function.
Effect of over-expression of AtPGP-1 in plants: The over-expression of AtPGP-1 was able to confer resistance to cycloheximide in plants (FIGS. 4A and 6) and to the cytokinin, N6-(2isopentenyl)adenine (21P) (FIG. 4B). These results had not been observed previously and in fact, the prior art actually teaches away from this finding suggesting that over-expression of plant AtPGP-1 is not involved in drug resistance (Sidler. et al., 1998). Therefore, this result was particularly unexpected in plants. Additionally, since Arabidopsis plants overexpressing AtPGP-1 are able to grow in both cycloheximide and cytokinin, this suggests that the conference of drug resistance by AtPGP-1 is likely to be seen with other chemicals as well and is not an isolated phenomenon.
Effect of over-expression of apyrase on drug resistance in plants: Another unexpected result was obtained when the plant apyrase gene was over-expressed in plants. Over-expression of apyrase in plants resulted in the conference of resistance to cycloheximide (FIGS. 4A and 6). The same result was obtained when the plants were grown in the presence of a cytokinin, N6-(2isopentenyl)adenine (FIG. 4B). In fact, over-expression of apyrase is surprisingly able to raise the germination rate above the level obtained by the over-expression of the MDR gene AtPGP-1 (FIGS. 4A, 4B and 6). Just as under-expression of phosphatase activity in a yeast mutant lacking two potent extracellular phosphatases diminished its resistance to cycloheximide (FIG. 3A), over-expression of a powerful extracellular ATP phosphatase in plants bolstered resistance. The fact that higher resistance was found in plants genetically manipulated only with respect to phosphatase over-expression and not MDR1, indicates that there likely exists other ATP-symporters used in detoxification in addition to MDR1. Minimally, the stronger ATP gradient set up by apyrase in the transgenic plants affects the kinetics of the wild-type MDRI.
Example 5
ATP Efflux in Yeast and Plants Overexpressing AtPGP-1
A. Materials and Methods
ATP collection: Yeast cells used in the luciferase assays were grown for two days and then transferred to Lsh media at the time of the assay. From this time forward, the cells were kept at room temperature on a rotator. Every hour a 1 ml aliquot was taken, the cells in the aliquot were counted on a hemocytometer, a methylene blue viability assay was performed (Boyum and Guidotti, 1997), the cells were centrifuged, and the supernatant was stored in liquid nitrogen until all the aliquots were collected. For luciferase assays involving plants, Arabidopsis thaliana plants were grown in sterile culture at 22° C. under 150-200 pE of continuous light for at least 15 days. Foliar ATP was collected by placing a single 30 pl drop of luciferase buffer (Analytical Luminescence Laboratory, Cockeysville, Md.) on a leaf and, without making direct physical contact with the plant, the droplet was immediately collected and snap frozen. For each leaf, the area was approximated as an integrated area of a 2-D image of the leaf using NIH 1.52 software (Shareware, NIH).
Luminometry: Samples were reconstituted to a 100 pl final volume in Firelight™ buffer (Analytical Luminescence Laboratory, Cockeysville, Md.). After the buffer was added, all samples were kept on ice. ATP standards were reconstituted in 100 μl of Firelight™ buffer and the standards and sample were loaded into a 96-well plate and read on an automated Dynex Technologies Model MLX luminometer (Dynex Technologies, Chantilly, Va.). Samples were processed with the addition of 50 μl of Firelight™ enzyme (Analytical Luminescence Laboratory, Cockeysville, Md.) followed by a reading delay of 1.0 second and an integration time of 10 seconds. Output was taken as an average for the integration time and then averaged for multiple samples. The sample handling time was less than 2 hours.
Pulse Chase experiments: Yeast were grown to saturation in liquid medium, as described above, centrifuged, and resuspended in fresh medium containing 1 μCi/ml 3H-adenosine (Amersham, Arlington Heights, Ill.). The cells were rotated at room temperature for 20 minutes to allow adenosine uptake. After 20 minutes the cells were centrifuged. The pellet was washed twice in ice cold medium, resuspended in culture medium at room temperature, divided equally between five types (five per cell line), and placed on a rotator. Every ten minutes a separate tube from each cell line was centrifuged and the pellet and supernatant were placed in separate scintillation vials. The efflux activity was expressed as the ratio of counts in the supernatant to counts in the pellet.
B. Results
The ATP effluxed by the plant MDR1, AtPGP-1, over-expressed in yeast: In wild-type cells there is a steady-state level of ATP in the extracellular fluid, which is to say that the ATP outside the cells is rapidly degraded by phosphatases and does not accumulate over time (FIG. 7). However, the expression of the AtPGP-1 doubled this steady-state level (FIG. 8). If the yeast mutant, YMR4, which is deficient in extracellular phosphatase activity, is analyzed, there was a noticeable accumulation of ATP in the extracellular fluid compared to a control mutant transformed with empty plasmid pVT101 (FIG. 9). In addition to ATP measurements based on luminometry performed on a kinetic time-scale of hours, an earlier differential ATP efflux in MDRI expressing cells by pulse chase experiments was demonstrated (FIG. 10). Furthermore, Arabidopsis thaliana plants from two independently transformed lines, that constitutively express the AtPGP-1 protein, showed a significant accumulation of ATP on their leaf surfaces (FIG. 11). Taken together, these data demonstrate the absolute ability of plant MDRI, AtPGP1, to transport ATP from inside the cell to the outside. Moreover, these data show that ATP efflux channels and phosphatases both have roles in the steady-state level of ATP outside of the cell. This is the first demonstration of the importance of extracellular ATP steady-state levels, and the importance of an ATP gradient across biological membranes in the modulation of drug resistance.
Example 6
A Two-Component System is Found in Arabidopsis Plants
A. Materials and Methods
Plant Growth: Arabidopsis seeds were sown in a solid germination media containing MS salts (Sigma Chemical, St. Louis, Mo.), 2% sucrose, 0.8% agar, and vitamins (Valvekens et al., 1992). For selection assays, one of the following, or a combination of both, was added to media (cooled to less than 50° C. before adding) immediately prior to pouring into plates: cycloheximide at a final concentration of 500 ng/ml; α,β-methyleneadenosine 5′-diphosphate at a final concentration of 1 mM. Plant growth was measured by germination percentage after 10-20 days.
All other materials and methods were discussed above in Example 4.
B. Results
Effects of phosphatase inhibitor on plants overexpressing AtPGP-1: FIG. 12 shows that when wild-type and AtPGP-1 overexpressing (MDR OE) Arabidopsis thaliana plants were either treated with nothing (lane 1), cycloheximide (lane 2), a,(3-methyleneadenosine 5′-diphosphate (phosphatase inhibitor) (lane 3), or cycloheximide and phosphatase inhibitor (lane 4), both the wild-type and the AtPGP-1 overexpressing plants were affected similarly by the presence of phosphatase inhibitor. While the AtPGP-1 overexpressing plants grew significantly better in the presence of cycloheximide alone with a 50% germination rate for the AtPGP-1 overexpressing plants and a 2% germination rate for the wild-type plants, similar germination rates were seen for both the AtPGP-1 overexpressing and wild-type plants in the presence of either phosphatase inhibitor alone (83% and 90% germination respectively) or cycloheximide plus phosphatase inhibitor (no germination at all). The addition of phosphatase inhibitor surprisingly destroys the ability of the AtPGP-expressing plants to grow in the presence of cycloheximide. These data suggest that phosphatases are involved in the conference of drug resistance in plants and that there is a two-component system similar to that demonstrated in yeast in Example 4 and 5 above in which an MDR-like protein and an ATP-gradient-maintaining ectophosphatase are important in modulating drug resistance.
Example 7
The ATP Gradient Directly Effects Drug Resistance in Cells
A. Materials and Methods
Cell lines: Cell lines were the same as those described above in Example 4 and 5. YMR4 MDRI is the phosphatase mutant yeast strain overexpressing AtPGP-1; YMR4 pVT011 contains vector alone; INVSC MDRI is the wild-type yeast strain overexpressing AtPGP-1; and INVSC pVT101 contains vector alone.
Selection in drug: To create drug resistant yeast strains, all four cell lines were grown up in the presence of 500 ng/ml of cycloheximide, and transferred to other cycloheximide containing plates after a period of four to six days. This transfer of cell lines and subculturing continued such that the yeast cells grew in the presence of cycloheximide for a period of at least a month. Cells cultured in media alone: To create cell lines that had not been preselected for their ability to grow in drug, yeast strains were grown on plates containing YNB (Bio101, Vista, Calif.) without uracil (-URA) to maintain the presence of the vector (which supplies URA) without any drugs added.
Growth of cells in suspension for ATP and drug selection experiments: Cells were transferred into 5 ml YNB-URA liquid media for turbidity measurements. All cell lines (both non-drug selected and drug-selected) were grown in media with the addition of either nothing, 500 ng/ml cycloheximide, 100 mM ATP, or 500 ng/ml cycloheximide and 100 mM ATP. Turbidity readings were taken after 48 hours.
Growth of cell lines in suspension for salvage pathway experiments: All cell lines were grown in liquid media either containing drug (for the drug selected lines) or not containing drug (for the non-drug selected lines). When the cultures reached a turbidity of 1.00 as measured at a wavelength of 600 in a spectrophotometer (OD600=1.00), 10 μl of each culture was then removed and placed in either media with nothing added, 3 mM potassium phosphate; 3 mM adenosine; 9 mM potassium phosphate and 3 mM adenosine (for controls); potassium phosphate and cycloheximide; adenosine and cycloheximide; adenosine, cycloheximide, and potassium phosphate. Cell cultures were further grown for 72 hours, and their turbidity was determined by OD600 readings on a spectrophotometer.
Growth of cell lines for nigericin experiments: Drug selected lines were removed from cycloheximide containing plates and placed in 5 ml liquid media containing 5 ng/ml cycloheximide. Cell cultures were allowed to grow until they reached an OD600 reading of 1.00, and then 10 μl from each culture was removed and transferred to culture tubes containing 5 ml of liquid media and 25 pg/ml nigericin. OD600 readings were recorded daily for a period of up to 72 hours to determine growth.
B. Results
An ATP gradient is critical in MDR: The importance of the ATP gradient in MDR in yeast cells was demonstrated by showing that the growth of cells which were previously grown in drug and had developed resistance to the drug, were not able to grow in high levels of ATP unless they were overexpressing AtPGP-1 (FIG. 13). Cells which had not been previously selected in drug were able to grow in the presence of high levels of ATP (FIG. 13). These data emphasize that the loss of an ATP gradient is previously resistant cell lines abolishes resistance. This result is new to the understanding of MDR and has led to vast insight into the understanding of the mechanism by which MDR-ABC transporters confer resistance to cells and to methods to modulate such resistance. Moreover, when cells were grown in high levels of ATP and drug (cycloheximide), even the cell lines which had previously showed resistance to drug were unable to grow in the presence of drug and ATP. These data indicate that when the ATP gradient across biological membranes is destroyed (by the presence of high extracellular levels of ATP), efflux a of drugs cannot be achieved and therefore, drug resistance is abolished. In summary, the multidrug resistance channel is not functional without an ATP gradient.
The drug resistance is not due to an adenosine salvage pathway: In order to address whether the involvement of a nucleotide salvage pathway was responsible for the results of the present invention, yeast cells were cultured in the presence of extracellular adenosine and extracellular phosphate. The acid phosphatase yeast mutant, YMR4, was selected because its decreased ectophosphatase activity makes it an ideal candidate for studying the effect of extracellular nucleotides on growth. If an adenosine salvage pathway were involved, then the presence of extracellular adenosine or possibly phosphate should help cells recoup the intracellular ATP losses due to ATP/drug efflux and should help cells grow in the presence of drug whether or not the cells were overexpressing AtPGP-1. In contrast, however, the addition of adenosine or phosphate to the media did not enhance resistance to the cells (FIG. 14). In fact, cells overexpressing AtPGP-1 grew best in drug alone, with the addition of adenosine and/or phosphate being slightly inhibitory. Furthermore, cells which did not express AtPGP-1 were unable to grow in drug regardless of the presence of adenosine and/or phosphate. These data suggest that an adenosine salvage pathway is not the principal mechanism at work in the present invention.
Example 8
High Throughput Screen for Isolating Apyrase Inhibitors
A. Materials and Methods
Small Molecule Library: A small molecule library (DIVERSet format F), which was specifically constructed to maximize structural diversity in a relatively small library (9600 compounds), was obtained from ChemBridge Corporation (San Diego, Calif.). The small molecules (supplied in 0.1 mg dehydrated aliquots) were dissolved in DMSO, transferred to a 96 well plate, and tested for their ability to inhibit apyrase activity.
The assay: A stringent screen to test the ability of small molecules to disrupt the ATPase activity of the apyrase enzyme was developed based on phosphate-mobylate complexation. The assay was a modification of a phospholipase assay developed by Hergenrother et al. (1997): Under normal conditions, the apyrase enzyme liberates phosphate from ATP present in the reaction. The liberated phosphate quickly forms a complex upon addition of a small amount of acidified molybdate and ascorbate allowing for the production of a very dark blue color (the less phosphate liberated, the less blue color). Control reactions were performed with heat inactivated apyrase enzyme. Color intensity was detected on an Alpha Imager 2000 with AlphaEase™ software (Alpha Innotech, San Leandro, Calif.). Color changes were also evident by the naked eye. A Biomek 2000 robot (Beckman, Fullerton, Calif.) was used for screening the 9600 samples.
To each well of the 96 well plates containing a small molecule from the library, 100 pI of reaction buffer (60 mM HEPES, 3 MM MgCl2, 3 mM CaCl2, 3 mM ATP pH 7.0) was added. The apyrase (potato apyrase grade VI, Sigma Chemical, St. Louis, Mo.) enzyme (0.1 units) was added in a 5 pI volume and the reaction was allowed to proceed at room temperature for 60 minutes.
Three buffers were used to visualize activity: Buffer A: 2% Ammonium molybdate in water Buffer B: 1 I% Ascorbic acid in 37.5% aqueous TCA. Buffer C: 2% trisodium citrate, 2% acetic acid.
Immediately before developing the assay, buffers A and B were mixed in a 1:1 5 ratio. 50 pl of A:B was added to each well. The 96 well plate was then vibrated on a table surface to mix the solution. The deep blue color developed after approximately 2 minutes. After 2 minutes, 50 p.l of buffer C was added to each well and the blue color became darker, increasing the sensitivity of the assay. The color intensified for up to one hour with no accompanying color change in the control wells containing heat inactivated apyrase enzyme. The color intensity for a single plate was measured on an Alpha Imager 2000 with AlphaEase™ software (Alpha Innotech, San Leandro, Calif.).
B. Results:
Nineteen positives were identified from the 9600 compound DIVERSet library. Dose response assays revealed that fourteen showed weak inhibition, two showed medium inhibition (Formulas N and V), and three showed relatively strong inhibition (Formulas I, II and III).
All of the compositions and methods disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure. While the compositions and methods of this invention have been described in terms of preferred embodiments, it will be apparent to those of skill in the art that variations may be applied to the compositions and methods and in the steps or in the sequence of steps of the method described herein without departing from the concept, spirit and scope of the invention. More specifically, it will be apparent that certain agents which are both chemically and physiologically related may be substituted for the agents described herein while the same or similar results would be achieved. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims.
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