Claims
- 1. A method of treating a subject having a chronic infection comprising:
a) identifying a subject suffering from a chronic infection; b) administering at least one monocyte maturation-promoting agent, wherein said monocyte maturation-promoting agent promotes the maturation of monocytes; and c) administering a compound selected from the group consisting of a ROS inhibitor and a ROS scavenger in a pharmaceutically acceptable form.
- 2. The method of claim 1, wherein said at least one monocyte maturation-promoting agent is a cytokine selected from the group consisting of IL-1, GM-CSF, IL-3, IL-4, IL-6, TNF-α, G-CSF, M-CSF, IL-12, IL-15, and IL-18.
- 3. The method of claim 1, wherein said chronic infection is caused by a virus.
- 4. The method of claim 3, wherein the virus is selected from the group consisting of adenovirus, cytomegalovirus, Epstein-Barr virus, herpes simplex virus 1, herpes simplex virus 2, human herpesvirus 6, varicella-zoster virus, hepatitis B virus, hepatitis D virus, papilloma virus, parvovirus B19, polyomavirus BK, polyomavirus JC, hepatitis C virus, measles virus, rubella virus, human immunodeficiency virus (HIV), human T cell leukemia virus I, and human T cell leukemia virus II.
- 5. The method of claim 1, wherein said chronic infection is caused by a parasite.
- 6. The method of claim 5, wherein said parasite is selected from the group consisting of Leishmania, Toxoplasma, Trypanosoma, Plasmodium, Schistosoma, and Encephalitozoon.
- 7. The method of claim 1, wherein the administration of said at least one monocyte-maturation promoting agent and said compound are performed simultaneously.
- 8. The method of claim 1, wherein the administration of said compound is performed within 24 hours of the administration of said at least one monocyte-maturation promoting agent.
- 9. The method of claim 1, wherein said ROS inhibitor is selected from the group consisting of histamine, histamine dihydrochloride, histamine phosphate, other histamine salts, esters, prodrugs, histamine receptor agonists, serotonin, 5HT agonists, and an endogenous histamine releasing compound.
- 10. The method of claim 1, wherein said ROS scavenger is selected from the group consisting of catalase, glutathione peroxidase, ascorbate peroxidase, vitamine A, vitamin E, or vitamin C.
- 11. The method of claim 1, wherein said compound and said at least one monocyte maturation-promoting agent are administered over a period of time between about one week to one year.
- 12. The method of claim 1, wherein said compound and said at least one monocyte maturation-promoting agent are administered parenterally.
- 13. The method of claim 3, further comprising administering an anti-viral agent to said subject.
- 14. The method of claim 5, further comprising administering an anti-parasitic therapy to said subject.
RELATED APPLICATIONS
[0001] This application is a divisional application of U.S. Pat. application Ser. No. 09/974,410, filed on Oct. 9, 2001, which claims priority to Provisional Application No. 60/240,299 entitled METHODS AND COMPOSITIONS FOR PROMOTING THE MATURATION OF MONOCYTES filed on Oct. 12, 2000. The subject matter of the aforementioned provisional application is hereby incorporated by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60240299 |
Oct 2000 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09974410 |
Oct 2001 |
US |
Child |
10160368 |
May 2002 |
US |