Methods and compositions for the identification and assessment of prostate cancer therapies and the diagnosis of prostate cancer

Abstract

The invention concerns two classes of differentially regulated genes: 1) genes that are more highly expressed in prostate cancer cells treated with testosterone than in untreated prostate cancer cells; and 2) genes that are more highly expressed in prostate cancer cells treated with bicalutamide, an anti-androgenic compound, than in untreated prostate cancer cells. Disclosed are methods for selecting and monitoring the effectiveness of therapeutic agents used for the treatment of prostate cancer. Also disclosed are methods for identifying novel therapeutic agents for the treatment of prostate cancer and methods and compositions for preventing, treating, and diagnosing prostate cancer.

Description

BACKGROUND OF THE INVENTION

Prostate cancer is the most commonly diagnosed cancer in American men and the second most common cause of death from cancer in American men.

Androgen withdrawal, by castration or through the use of an anti-androgenic drug, is the preferred treatment method for prostate cancer.

Bicalutamide (casodex) is a relatively potent, orally active anti-androgenic drug. Approximately 80% of the prostate cancer patients treated with bicalutamide respond to the treatment; however, most patients eventually relapse.

Prostate cancer, like other cancers, can be viewed as a breakdown in the communication between tumor cells and their environment, including their normal neighboring cells. Growth-stimulatory and growth-inhibitory signals are routinely exchanged between cells within a tissue. Normally, cells do not divide in the absence of stimulatory signals, and, likewise, will cease dividing in the presence of inhibitory signals. In a cancerous or neoplastic state, a cell acquires the ability to “override” these signals and to proliferate under conditions in which a normal cell would not grow.

In general, tumor cells must acquire a number of distinct aberrant traits in order to proliferate in an abnormal maimer. Reflecting this requirement is the fact that the genomes of certain well-studied tumors carry several different independently altered genes, including activated oncogenes and inactivated tumor suppressor genes.

In addition to abnormal cell proliferation, cells must acquire several other traits for tumor progression to occur. For example, early on in tumor progression, cells must evade the host immune system. Further, as tumor mass increases, the tumor must acquire vasculature to supply nourishment and remove metabolic waste. Additionally, cells must acquire an ability to invade adjacent tissue. In many cases cells ultimately acquire the capacity to metastasize to distant sites.

It is apparent that the complex process of tumor development and growth must involve multiple gene products. It is therefore important to define the role of specific genes involved in tumor development and growth and identify those genes and gene products that can serve as targets for the diagnosis, prevention and treatment of cancers.

In the realm of cancer therapy it often happens that a therapeutic agent that is initially effective for a given patient becomes, overtime, ineffective or less effective for that patient. The very same therapeutic agent may continue to be effective over a long period of time for a different patient. Further, a therapeutic agent which is effective, at least initially, for some patients is completely ineffective or even harmful for other patients. Accordingly, it would be useful to identify genes and/or gene products that represent prognostic markers with respect to a given therapeutic agent or class of therapeutic agents. It then may be possible to determine which patients will benefit from particular therapeutic regimen and, importantly, determine when, if ever, the therapeutic regime begins to lose its effectiveness. The ability to make such predictions would make it possible to cease a therapeutic regime which has lost its effectiveness well before its loss of effectiveness becomes apparent by conventional measures.

SUMMARY OF THE INVENTION

The invention features methods for selecting and monitoring the effectiveness of therapeutic agents used for the treatment of prostate cancer. The invention also features methods for identifying novel therapeutic agents for the treatment of prostate cancer. The invention also features methods and compositions diagnosing prostate cancer and methods and compositions for preventing, treating, and diagnosing prostate cancer.

The invention is based, in part, on the identification of two classes of differentially regulated genes: 1) genes that are more highly expressed in prostate cancer cells treated with testosterone than in untreated prostate cancer cells; and 2) genes that are more highly expressed in prostate cancer cells treated with bicalutamide, an anti-androgenic compound, than in untreated prostate cancer cells. Genes which are more highly expressed in testosterone-treated prostate cancer cells than untreated prostate cancer cells are listed in Table 1 (SEQ ID NOS: 1-40 and 86-130 ). Genes which are more highly expressed in bicalutamide-treated prostate cancer cells than untreated prostate cancer cells are listed in Table 2 (SEQ ID NOS: 41-85 and 131-191 ).

By examining the expression of one or more of these identified genes in a sample of prostate cancer cells, it is possible to determine whether a selected compound, e.g., an anti-androgenic compound, can be used to treat the prostate cancer. Importantly, this determination can be made on a patient by patient basis. Thus, one can determine whether or not a particular prostate cancer treatment is likely to benefit a particular patient. The invention also features methods for determining whether a particular prostate cancer has become refractory to treatment with an anti-androgenic compound or other therapeutic agent.

The invention also features diagnostic methods and prognostic methods which can be used to identify patients having or at risk for developing prostate cancer. The identified differentially expressed genes whose expression is increased in the presence of testosterone and/or the products of such genes can be used to identify cells exhibiting or predisposed development of prostate cancer thereby diagnosing individuals having, or at high risk for developing, prostate cancer. The detection of the differential expression of identified genes can be used to select therapies before the benign cells attain a malignant state and to design a preventive intervention in pre-neoplastic cells in individuals at high risk.

In the various methods of the invention, gene expression can be measured at the mRNA or protein level. Alternatively, expression can be measured indirectly by measuring the activity of the protein encoded by the identified gene.

The differentially expressed genes identified herein are potential targets for the development of therapeutic compounds. Genes that are expressed at a higher level in prostate cancer cells in the presence of testosterone than in the absence of testosterone are identified. Because testosterone is required for growth and survival of prostate cancer cells, genes whose expression is increased in the presence of testosterone are potential therapeutic targets. Thus, identifying compounds which reduce the expression of such a gene or reduce the activity of the product of such a gene forms the basis for the development of new therapeutic agents. In addition, as noted above, increased expression of these genes can serve as a prognostic or diagnostic indicator of prostate cancer. Moreover, where increased expression of these genes is observed during the course of a therapy, it can be expected that the therapy is or has become relatively ineffective.

Also identified are genes that are expressed in prostate cancer cells at a high level in the presence of the anti-androgenic drug bicalutamide than in the absence of bicalutamide. Because bicalutamide is known to inhibit the growth of prostate cancer cells, genes whose expression is increased in the presence of bicalutamide are potential therapeutic targets. Thus, identifying compounds which increase the expression of such a gene or increase the activity of the product of such a gene forms the basis for the development of new therapeutic agents. In addition, increased expression of these genes can serve as a indicator that a given therapy is effective.

The invention provides methods for the identification of compounds that modulate the expression of genes or the activity of gene products involved in prostate cancer as well as methods for the treatment of prostate cancer. Such methods can, for example, involve the administration of such modulatory compounds to individuals exhibiting symptoms or markers of prostate cancer.

This invention is based, in part, on systematic search strategies coupled with sensitive and high throughput gene expression assays, to identify genes differentially expressed in prostate tumor cells treated with different drugs. The search strategies and assays used herein permit the identification of all genes, whether known or novel, which are differentially expressed in, e.g., testosterone-treated prostate cancer cells relative to untreated prostate cancer cells.

This comprehensive approach and evaluation permits the discovery of novel genes and gene products, as well as the identification of an array of genes and gene products (whether novel or known) that are influenced by drugs and natural products which are known to influence the growth and survival of prostate cancer cells. Thus, the present invention makes possible the identification and characterization of targets useful for rationale drug design and for the prognosis, diagnosis, monitoring, treatment, and prevention of prostate cancer.

In some respects the differentially expressed genes described herein can be used in the same manner and prostate specfic antigen, a commonly used marker for prostate cancer and pre-cancerous conditions related to prostate cancer.

“Differential expression,” as used herein, refers to both quantitative, as well as qualitative, differences in the expression pattern of a gene in tumor cells treated with a particular drug and untreated tumor cells. Differentially expressed genes can represent “fingerprint genes,” and/or “target genes.”

“Fingerprint gene,” as used herein, refers to a differentially expressed gene whose expression pattern can be utilized as part of a prognostic or diagnostic marker for the evaluation of prostate cancer or which, alternatively, can be used in methods for identifying compounds useful for the treatment of prostate cancer or evaluating the effectiveness of a prostate cancer treatment. For example, the effect of the compound on the fingerprint gene expression pattern normally displayed in connection with prostate cancer can be used to evaluate the efficacy of the compound as a treatment for prostate cancer or can, additionally, be used to monitor patients undergoing clinical evaluation for the treatment of prostate cancer.

A “fingerprint pattern,” as described herein, is the pattern generated when the expression pattern of a series (which can range from two up to all the fingerprint genes which exist for a given state) of fingerprint genes is determined. A fingerprint pattern can be used in the same diagnostic, prognostic and compound identification methods as the expression of a single fingerprint gene.

A “target gene,” as described herein, is a differentially expressed gene involved in prostate cancer such that modulation of the level of target gene expression or of target gene product activity can act to prevent and/or ameliorate symptoms of the prostate cancer. Compounds that modulate the expression of the target gene or the activity of the target gene product can be used in the treatment of prostate cancer. Still further, compounds that modulate the expression of the target gene or activity of the target gene product can be used in treatments to deter benign cells from developing into prostate cancer cells. Still further, compounds that modulate the expression of the target gene or activity of the target gene product can be used to design a preventive intervention in pre-neoplastic cells in individuals at high risk.

DESCRIPTION OF THE FIGURES

FIG. 1 depicts the nucleotide sequence of SEQ ID NO: 1.

DETAILED DESCRIPTION OF THE INVENTION

The invention is based, in part, on the identification of genes that are differentially expressed in prostate cancer cells treated with selected compounds. By evaluating the expression pattern of a variety of genes in the presence and absence of a selected compound it is possible to create a profile of the response of prostate cancer cells to the selected compound.

1. Identification of Differentially Expressed Genes

Described below are examples of methods which can be used to identify differentially expressed genes, i.e., genes whose expression in prostate cancer cells is altered by a selected compound, e.g., testosterone.

Differential expression refers to both quantitative, as well as qualitative differences the expression pattern of a gene or group of genes. Thus, a differentially expressed gene can qualitatively have its expression increased or decreased in, for example, testosterone-treated prostate cancer cells versus untreated prostate cancer cells.

In some cases, the difference in expression between treated and untreated (control) cells may be qualitative rather than quantitative. Thus, the expression of a selected gene might be detectable using a certain assay method in the presence of a given drug and undetectable using the same assay in the absence of the drug.

Alternatively, a differentially expressed gene can exhibit an expression level which differs, i.e., is quantitatively increased or decreased in treated cells versus control cells.

The degree to which expression differs need only be large enough to be visualized via standard characterization techniques, such as, for example, a differential display technique. Other standard, well-known characterization techniques by which expression differences can be visualized include, but are not limited to, quantitative reverse transcriptase (RT)-coupled PCR and Northern analyses and RNase protection techniques and methods which employ arrays of nucleic acid molecules, e.g., cDNAs linked to a solid support, e.g., a Gene Expression Micro-Array™ (Synteni, Inc.; Fremont, Calif.).

a) Approaches to the Identification of Differentially Expressed Genes

There are a variety of approaches (or paradigms) which can be used to identify differentially expressed genes. In all cases, drug-treated and untreated cells (or cells treated with different drugs) are compared. The paradigms differ in the source of the cells that are differentially treated. Thus, the cells can be differentially treated in vitro prostate cancer cells, e.g., a cells of a prostate cancer cell line (an “in vitro paradigm”), differentially treated representatives of an animal model of prostate cancer (an “in vivo paradigm”), or differentially treated prostate cancer patients (a “clinical paradigm”).

Once a particular differentially expressed gene has been identified through the use of one paradigm, its expression pattern can be further characterized, for example, by studying its expression in a different paradigm. A gene can, for example, be regulated one way, i.e., can exhibit one differential gene expression pattern, in a given paradigm, but can be regulated differently in another paradigm. The use, therefore, of multiple paradigms can be helpful in distinguishing the roles and relative importance of particular genes in prostate cancer.

In an in vitro paradigm, differentially expressed genes are detected by comparing the pattern of gene expression between the experimental (drug-treated) prostate cancer cells and control (untreated or treated with a different drug) prostate cancer cells.

In an in vivo paradigm, animal models of prostate cancer can be utilized to discover differentially expressed genes. A variety of animal models can be used in an in vivo paradigms. Matched animal are treated with a drug or left untreated (or treated with a different drug).

In a clinical paradigm samples from surgical and biopsy specimens are used. Such specimens can represent normal tissue, primary, secondary or metastasized tumors obtained from patients. Surgical specimens can be procured under standard conditions involving freezing and storing in liquid nitrogen (see, for example, Karmali et al., 1983, Br. J. Cancer 48:689-696.) RNA from specimen cells is isolated by, for example, differential centrifugation of homogenized tissue, and analyzed for differential expression relative to other specimen cells, preferably cells obtained from the same patient at a different time, e.g., before drug treatment, during treatment with a different drug, or at an earlier time during treatment with the same drug.

b) Methods for Identifying Differentially Expressed Genes

In order to identify differentially expressed genes, RNA, either total or mRNA, can be isolated from cells utilized in paradigms such as those described above. Any RNA isolation technique which does not select against the isolation of mRNA can be utilized for the purification of such RNA samples (see, e.g., Ausubel et al., eds., 1987-1997, Current Protocols in Molecular Biology , John Wiley & Sons, Inc. New York). Additionally, large numbers of tissue samples can readily be processed using techniques well known to those of skill in the art, such as, for example, the single-step RNA isolation process of Chomczynski (1989, U.S. Pat. No. 4,843,155).

Transcripts within the collected RNA samples which represent RNA produced by differentially expressed genes can be identified by utilizing a variety of methods which are well known to those of skill in the art. For example, differential screening (Tedder et al., 1988, Proc. Natl. Acad. Sci. USA 85:208-212), subtractive hybridization (Hedrick et al., 1984, Nature 308:149-153; Lee et al., 1984, Proc. Natl. Acad. Sci. USA 88:2825), and, preferably, differential display (Liang and Pardee 1993, U.S. Pat. No. 5,262,311), can be utilized to identify nucleic acid sequences derived from genes that are differentially expressed.

Differential screening involves the duplicate screening of a cDNA library in which one copy of the library is screened with a total cell cDNA probe corresponding to the mRNA population of sample while a duplicate copy of the cDNA library is screened with a total cDNA probe corresponding to the mRNA population of a second sample. For example, one cDNA probe can correspond to a total cell cDNA probe of a cell or tissue derived from a control sample, while the second cDNA probe can correspond to a total cell cDNA probe of the same cell type derived from an experimental (e.g, drug-treated) sample. Those clones which hybridize to one probe but not to the other potentially represent clones derived from genes differentially expressed in the cell of interest in control versus experimental samples.

Subtractive hybridization techniques generally involve the isolation of mRNA taken from two different sources, e.g., treated and untreated cells, the hybridization of the mRNA or single-stranded cDNA reverse-transcribed from the isolated mRNA, and the removal of all hybridized, and therefore double-stranded, sequences. The remaining non-hybridized, single-stranded cDNAs, potentially represent clones derived from genes that are differentially expressed in the two mRNA sources. Such single-stranded cDNAs are then used as the starting material for the construction of a library comprising clones derived from differentially expressed genes.

Differential display is a procedure which, utilizing the well-known polymerase chain reaction (PCR; the experimental embodiment set forth in Mullis 1987, U.S. Pat. No. 4,683,202), allows for the identification of sequences derived from genes which are differentially expressed. First, isolated RNA is reverse-transcribed into single-stranded cDNA, utilizing standard techniques which are well known to those of skill in the art. Primers for the reverse transcriptase reaction can include, but are not limited to, oligo dT-containing primers, preferably of the 3′ primer type of oligonucleotide described below. Next, this technique uses pairs of PCR primers, as described below, which allow for the amplification of clones representing a random subset of the RNA transcripts present within any given cell. Utilizing different pairs of primers allows each of the mRNA transcripts present in a cell to be amplified. Among such amplified transcripts can be identified those which have been produced from differentially expressed genes.

The 3′ oligonucleotide primer of the primer pairs can contain an oligo dT stretch of 10-13 dT nucleotides at its 5′ end, preferably 11, which hybridizes to the poly(A) tail of mRNA or to the complement of a cDNA reverse transcribed from an mRNA poly(A) tail. Second, in order to increase the specificity of the 3′ primer, the primer can contain one or more, preferably two, additional nucleotides at its 3′ end. Because, statistically, only a subset of the mRNA derived sequences present in the sample of interest will hybridize to such primers, the additional nucleotides allow the primers to amplify only a subset of the mRNA derived sequences present in the sample of interest. This is preferred in that it allows more accurate and complete visualization and characterization of each of the bands representing amplified sequences.

The 5′ primer can contain a nucleotide sequence expected, statistically, to have the ability to hybridize to cDNA sequences derived from the tissues of interest. The nucleotide sequence can be an arbitrary one, and the length of the 5′ oligonucleotide primer can range from about 9 to about 15 nucleotides, with about 13 nucleotides being preferred.

Additionally, arbitrary primer sequences cause the lengths of the amplified partial cDNAs produced to be variable, thus allowing different clones to be separated by using standard denaturing sequencing gel electrophoresis.

PCR reaction conditions should be chosen which optimize amplified product yield and specificity, and, additionally, produce amplified products of lengths which can be resolved utilizing standard gel electrophoresis techniques. Such reaction conditions are well known to those of skill in the art, and important reaction parameters include, for example, length and nucleotide sequence of oligonucleotide primers as discussed above, and annealing and elongation step temperatures and reaction times.

The pattern of clones resulting from the reverse transcription and amplification of the mRNA of two different cell types is displayed via sequencing gel electrophoresis and compared. Differences in the two banding patterns indicate potentially differentially expressed genes.

Once potentially differentially expressed gene sequences have been identified via bulk techniques such as, for example, those described above, the differential expression of such putatively differentially expressed genes should be corroborated. Corroboration can be accomplished via, for example, such well-known techniques as Northern analysis, quantitative RT-coupled PCR or RNase protection.

Upon corroboration, the differentially expressed genes can be further characterized, and can be identified as target and/or fingerprint genes.

Amplified sequences of differentially expressed genes obtained through differential display can be used to isolate the full length clones of the corresponding gene. The full-length coding portion of the gene can readily be isolated, without undue experimentation, by molecular biological techniques well known in the art. For example, the isolated differentially expressed amplified fragment can be labeled and used to screen a cDNA library. Alternatively, the labeled fragment can be used to screen a genomic library.

PCR technology can also be utilized to isolate full-length cDNA sequences. Thus, the isolated amplified gene fragments (of about at least 10 nucleotides, preferably longer, of about 15 nucleotides) obtained through differential display have their 5′ terminal end at some random point within the gene and have 3′ terminal ends at a position corresponding to the 3′ end of the transcribed portion of the gene. Once nucleotide sequence information from an amplified fragment is obtained, the remainder of the gene (i.e., the 5′ end of the gene, when utilizing differential display) can be obtained using, for example, RT-PCR.

A reverse transcription reaction can then be performed on the RNA using an oligonucleotide primer complementary to the mRNA that corresponds to the amplified cloned fragment, for the priming of first strand synthesis. Because the primer is anti-parallel to the mRNA, extension will proceed toward the 5′ end of the mRNA. The resulting RNA/DNA hybrid can then be “tailed” with guanines using a standard terminal transferase reaction, the hybrid can be digested with RNAase H, and second strand synthesis can then be primed with a poly-C primer. Using the two primers, the 5′ portion of the gene is then amplified using PCR. Sequences obtained can then be isolated and recombined with previously isolated sequences to generate a full-length cDNA of the differentially expressed gene. For a review of cloning strategies and recombinant DNA techniques which can be used, see, e.g., Sambrook et al., 1989, Molecular Cloning, A Laboratory Manual , Cold Springs Harbor Press, N.Y.; and Ausubel et al., supra.

II. Examples of the Identification of Differentially Expressed Genes

Described below is the identification of two classes of genes which are differentially expressed in prostate cancer cells.

The first example concerns the identification of 40 genes whose expression is increased in prostate cancer cells in the presence of testosterone. It is known that testosterone is required for the growth and survival of prostate cancer cells. Accordingly, genes whose expression is increased in the presence of testosterone can be used as markers to identify prostate cancers which might be successfully treated by the use of an anti-androgenic drug. In addition, these genes can be used as markers to identify prostate cancers which may have become refractory to anti-androgenic treatment. Because higher expression of these genes is associated with testosterone-exposed prostate cancer cells, they can be used as diagnostic and prognostic markers to identify individuals suffering from or at risk for developing prostate cancer. These genes and the proteins they encode can also be used to identify novel therapeutic agents for treatment of prostate cancer and as diagnostic markers.

The second example concerns the identification of 45 genes whose expression is increased in prostate cancer cells in the presence of bicalutamide, an anti-androgenic compound that is commonly used to treat prostate cancer. Because the increased expression of these genes in prostate cancer cells is associated with a successful treatment for prostate cancer, these genes can be used as markers to identify novel therapeutic compounds and to monitor the course/effectiveness of a therapy, particularly an anti-androgenic therapy.

a) EXAMPLE 1

Identification of Genes Whose Expression is Increased in the Presence of Testosterone

LNCaP cells were grown T162 flasks coated with Matrigel in RPMI-1640 medium supplemented with 10% FBS and 50 nM testosterone. Prior to testosterone treatment, the cells were pre-incubated for 24.5 hours in dye-free RPMI-1640 containing 2% charcoal stripped serum.

Five T162 flasks of pretreated cells were treated with testosterone-containing medium (dye-free RPMI-1640, 2% CSS, 100 nM testosterone, 0.09% DMSO). After 25 hours of incubation in testosterone-containing medium, the cells were detached from the flasks with trypsin and pelleted. Five T162 flasks of pretreated cells were used as a control. Untreated cells were collected in the same manner.

Total RNA was prepared from the cell pellets using the RNeasy protocol (Qiagen). Approximately 260 μg of total RNA was obtained from each cell pellet. Next, polyA+ RNA was prepared form approximately 240 μg of each total RNA sample using the Oligotex protocol (Qiagen), approximately 6 μg of polyA+ RNA was obtaining from each 240 μg total RNA sample, and 2 μg of each polyA+ RNA sample was used for the generation of subtraction libraries using the PCR-select protocol (Clontech; Palo Alto, Calif.).

The PCR products representing partial cDNAs of putatively differentially expressed mRNAs were subcloned into pCR2.1 (InVitrogen) and transformed into INValphaF 1 cells.

The differentially expressed genes were then identified by screening on a Gene Expression Micro-Array™ (Synteni, Inc.; Fremont, Calif.).

Table 1 is a list of identified genes whose expression is greater in testosterone-treated prostate cancer cells than untreated prostate cancer cells. Generally the genes are listed in ranked order. In some cases only a partial sequence is presented in the corresponding figure. The various methods described herein can employ complete sequences or fragments thereof.

TABLE 1
	Fold
	Increase In	SEQ ID
Gene	mRNA	NO.
Monoamine oxidase	5.5	1
Neprilysin	2.8	2
Cell division control protein 2 homolog (X05360)	*	3
Cell division protein kinase 6	3.1	4
5-hydroxytryptamine 2C receptor	*	5
Aryl hydrocarbon receptor nuclear translocator	4.6	6
Guanine nucleotide exchange factor MSS4	2.7	7
(U74324) (−76 nucleotide)
DNA mismatch repair protein MSH2	*	8
HEK2 protein tyrosine kinase receptor	2.6	9
Ras-like GTP-binding protein RAN	2.6	10
UDP glucuronosyltransferase precursor	2.8	11
(UGT2B15)
BM28 mRNA/DNA replication licensing factor	2.4	12
(huMCM2)
Yeast guanine nucleotide-binding protein beta	2.4	13
subunit-like protein
Thyroid receptor interactor (TRIP7) (L40357)	2.4	14
(−92 nucleotide)
Pyruvate kinase (M26252) = human TCB gene	2.3	15
encoding cytosolic thyroid hormone-binding
protein
EXT1 = putative tumor suppressor/hereditary	2.4	16
mult. exostoses candidate gene
Phospholipase A2 (M22430)	2.7	17
UDP-glucuronosyltransferase 2B7 precursor	3.9	18
WILMS' tumor protein (X51630)	*	19
Apolipoprotein B-100 precursor (XO4506)	*	20
Forkhead protein FREAC-2	*	21
S-adenosylmethionine decarboxylase	2.3	22
Kinesin-related protein	4.8	23
Spectrin alpha chain	3.5	24
KIAA0018 gene (D13643)	3.3	25
Myeloblast KIAA0130 gene (D50920)	3.3	26
Brain-expressed HHCPA78 homolog (S73591)	3	27
Vacuolar ATP synthase subunit AC39; or bovine	3.1	28
(P17694) NADH-ubiquinone oxidoreductase
49 kD subunit
Gelsolin precursor	2.8	29
Ankyrin G (ANK-3) (U13616)	2.7	30
High mobility group protein HMG1 (X12597)	2.6	31
S-adenosylmethionine decarboxylase proenzyme	2.5	32
(M21154)
p0071 protein (X81889)	2.4	33
F02A9.5 homolog	*	34
Eukaryotic initiation factor 1A	2.4	35
L-lactate dehydrogenase M chain	3	36
(X02152, M17516)
Cytochrome b5	3.3	37
Fibronectin (S00848, transformation-associated	2.8	38
human fragment)
Tubulin beta 1 chain	2.8	39
Histone H2AZ	2.5	40
STS (WI 12919)	7.7	86
ESTs {344156}	5.9	87
STS (WI-8530)	5	88
ESTs {128990}	5	89
ESTs {26259}	5	90
ESTs {48537}	4.5	91
ESTs {221118}	4.4	92
ESTs {195079}	4.3	93
ESTs {242643}	4.1	94
ESTs {41700}	4	95
ESTs {301487}	3.8	96
ESTs {469725}	3.7	97
Immunoglobulin rearranged H-chain V-region	3.6	98
(C-D-J Hg)
ESTs {249347}	3.5	99
ESTs {135326}	3.4	100
ESTs {177150}	3.1	101
ESTs {375900}	3.1	102
ESTs {46287}	3	103
ESTs {264293}	3	104
ESTs {429349}	3	105
ESTs {128055}	2.8	106
ESTs {415795}	2.8	107
ESTs {364618}	2.7	108
ESTs {52371}	2.6	109
ESTs {471083}	2.6	110
ESTs {23605}	2.5	111
ESTs {32161}	2.5	112
ESTs {364477}	2.5	113
54 kDa progesterone receptor-associated	2.5	114
immunophilin FKBP54
ESTs {488092}	2.5	115
ESTs {151339}	2.4	116
ESTs {174787}	2.4	117
ESTs {230447}	2.4	118
ESTs {131591}	2.3	119
ESTs {141115}	2.3	120
Simian T-cell lymphotropic virus type I DNA	2.3	121
for tax/rex region
ESTs {51591}	2.3	122
ESTs {297463}	2.3	123
ESTs {180082}	2.1	124
ESTs {133211}	*	125
Thymopoietin alpha	*	126
ESTs {52092}	*	127
ESTs {238656}	*	128
ESTs {428502}	*	129
Zinc finger protein	*	130

b) EXAMPLE 2

Identification of Genes Whose Expression is Increased in the Presence of Bicalutamide

LNCaP cells were grown in T162 flasks coated with Matrigel in RPMI-1640 medium supplemented with 10% FBS and 50 nM testosterone. Prior to bicalutamide treatment, cells were preincubated for 24.5 hours in dye-free RPMI-1640 containing 2% charcoal stripped serum.

Five T162 flasks of pretreated cells were treated with bicalutamide-containing medium (dye-free RPMI-1640, 2% CSS, 100 nM bicalutamide in DMSO). After 25 hours of incubation in bicalutamide-containing medium, LNCaP cells were detached from the flasks with trypsin and pelleted. Five T162 flasks of pretreated cells were used as a control. Untreated cells were collected in the same manner.

Total RNA was prepared from the cell pellets using the RNeasy protocol (Qiagen). Approximately 260 μg of total RNA was obtained form each cell pellet. Next, polyA+ RNA was prepared form approximately 240 μg of each total RNA sample using the Oligotex protocol (Qiagen), approximately 6 μg of polyA+ RNA was obtaining from each 240 μg total RNA sample, and 2 μg of each polyA+ RNA sample was used for the generation of subtraction libraries using the PCR-select protocol (Clontech; Palo Alto, Calif.).

The PCR products representing partial cDNAs of putatively differentially expressed mRNAs were subcloned into pCR2.1 (InVitrogen) and transformed into INValphaF 1 cells.

The diffentially expressed genes were then identified by screening on a Gene Expression Micro-Array™ (Synteni, Inc.; Fremont, Calif.).

Table 2 is a list of identified genes whose expression is greater in bicalutamide-treated prostate cancer cells than untreated prostate cancer cells. Generally the genes are listed in ranked order. In some cases only a partial sequence is presented in the corresponding figure. The various methods described herein can employ complete sequences or fragments thereof.

TABLE 2
	FOLD
	INCREASE	SEQ ID
GENE	IN mRNA	NO.
Cyclin-dependent kinase inhibitor 1 {268652}	4.5	41
Activating transcription factor 3 (ATF3)	11.5	42
{428248}
Defender against cell death 1 {488974}	2.9	43
Transcription factor ITF-2 {380738}	*	44
CCAAT/Enhancer binding protein BETA	*	45
{357095}
CLCN3 {346749}	2.4	46
Phosphotyrosine independent ligand p62 for the	5.8	47
Lck SH2 domain {510278}
Seryl-tRNA synthetase {510431}	4.3	48
D53 (hD53) {510461}	3.8	49
Unknown human protein {512334}	3.5	50
Thioredoxin reductase {510377}	2.6	51
Tryptophanyl-tRNA synthetase {510220}	*	52
ORF and HepG2 (identical sequence) {510258}	5.3	53
4F2 cell-surface antigen heavy chain {510504}	8.1	54
Asparagine synthetase {510206}	2.8	55
pM5 {509550}	2.3	56
Archain {488510}	2.3	57
Gravin {488106}	2.8	58
Metallothionein-II (mt-II) {484963}	*	59
Signal recognition particle receptor alpha subunit	2.6	60
{358710}
Phosphoenolpyruvate carboxykinase {363272}	3.4	61
Protein translation factor SUI1 homolog	2.7	62
{365542}
NADPH-flavin reductase {365775}	3.7	63
Peptidyl-prolyl CIS-trans isomerase B precursor	2.5	64
{376399}
Aspartate aminotransferase {417270}	3.1	65
OS-9 precursor {417136}	2.7	66
KIAA0025 and PIGHEP3 homologous region	5.3	67
{418227}
Glucosamine-fructose-6-phosphate	3.2	68
aminotransferase {469633}
ADP-ribosylation factor 1 {471384}	3.1	69
Glycyl-tRNA synthetase {471164}	3.6	70
Prion protein (PrP) {470074}	3.1	71
Mitochondrial serine hydroxymethyltransferase	2.4	72
{344080}
Alanyl-TRNA synthetase {343998}	3.8	73
bZIP protein NF-IL3A {343273}	*	74
Interleukin-8 precursor {328692}	*	75
Translocon-associated protein {324179}	2.5	76
Proto-oncogene tyrosine-protein kinase FYN	*	77
{323555}
Translation initiation factor 5 (elF5) {299843}	2.3	78
RESTIN {291620}	2.3	79
Transcription elongation factor S-II {257458}	2.8	80
Human clone 137308 {252491}	2.6	81
Glutamate-cysteine ligase regulatory subunit	4.1	82
{245939}
Fatty aldehyde dehydrogenase {208950}	3.1	83
MHC class I HLA-Bw58 gene {203448}	2.3	84
Mitochondrial NDA (P)+ dependent malic	2.5	85
enzyme {109375}
ESTs {44552}	*	131
ESTs {381626}	*	132
ESTs {486242}	*	133
Tryptophanyl tRNA sythestase (IFNWRS)	*	134
{489453}
AU-rich element RNA-binding protein AUF1	*	135
{510536}
GADD 153 = Growth arrest and DNA-damage	11.1	136
inductor gene {362009}
KIAA0025 gene {30476}	6.7	137
Phosphotyrosine independent ligand p62 for the	6.4	138
Lck SH2 domain {471392}
150 kDa oxygen-regulated protein ORP150	5.9	139
{486858}
78 KD Glucose regulated protein precursor	4	140
{366350}
Smad 1 {345928}	3.9	141
EST28g11 WATM1 {486703}	3.8	142
ESTs {322080}	3.7	143
Seryl-tRNA sythetase {129892}	3.6	144
HU-K4 {470677}	3.6	145
ESTs {126530}	3.5	146
ESTs {429327}	3.5	147
Vascular endothelial growth factor (VEGF (165))	3.2	148
{488697}
ESTs {50914}	3.1	149
ESTs {279847}	3.1	150
ESTs {361548}	3.1	151
ESTs {364730}	3.1	152
ESTs {470212}	3.1	153
ESTs {471210}	3.1	154
ESTs {289300}	3	155
ESTs {427725}	3	156
ESTs {428217}	2.9	157
rfp transforming protein {485268}	2.8	158
ESTs {487420}	2.8	159
60S RIBOSOMAL PROTEIN L18A {509699}	2.8	160
ESTs {31943}	2.7	161
ESTs {376271}	2.7	162
ESTs {469642}	2.7	163
ESTs {471826}	2.7	164
KIAA0262 {485008}	2.7	165
ESTs {292082}	2.6	166
ESTs {365557}	2.6	167
Immunogloblin light chain (lambda) {119218}	2.5	168
ELP-1 {147979}	2.5	169
TRAMP protein {149355}	2.5	170
ESTs {294078}	2.5	171
ESTs {291005}	2.5	172
ESTs {365907}	2.5	173
ESTs {427801}	2.5	174
ESTs {469515}	2.5	175
Tral mRNA for human homologue of murine	2.5	176
tumor rejection antigen gp96 {509486}
Biotin-[propionyl-CoA-carboxylase	2.4	177
(ATP-hydrolysing)] {176590}
Tral mRNA for human homologue of murine	2.4	178
tumor rejection antigen gp96 {242829}
Cancellous bone osteoblast mRNA for GS3786	2.4	179
{486005}
ESTs {509583}	2.4	180
ESTs {44551}	2.3	181
ESTs {245853}	2.3	182
ESTs {306075}	2.3	183
ESTs {322143}	2.3	184
ESTs {322749}	2.3	185
ESTs {359877}	2.3	186
ESTs {360446}	2.3	187
ESTs {360789}	2.3	188
Protein tyrosine kinase t-Rorl {418257}	2.3	189
ESTs {486712}	2.3	190
ESTs {489106}	2.3	191

III. The Use of Differentially Expressed Genes in Selecting and Monitoring Prostate Cancer Therapies

The expression level of identified differentially expressed genes may be used to assess patients undergoing clinical evaluation for the treatment of prostate cancer. Thus, the identified genes can be used to select an appropriate therapy for an individual and to monitor an ongoing therapy. They may also be utilized as surrogate markers to monitor clinical human trials of a drug being tested for their efficacy as a prostate cancer treatment. In either case, one or more of the identified differentially expressed genes may be utilized as a marker.

One can determine whether a given patient will benefit from anti-androgenic therapy by examining the expression level of one or more of the differentially expressed genes identified herein as being expressed at a higher level in prostate cancer cells in the presence of testosterone than in the absence of testosterone. If one or more of these genes is more highly expressed in the patient's prostate cancer cells than in normal prostate cells, the prostate cancer cells are more likely to respond to anti-androgenic therapy. As used herein, “anti-androgenic therapy” refers broadly to any therapy which interferes with or blocks the synthesis or action of an androgen. Similarly, “anti-testosterone therapy” refers broadly to any therapy which interferes with or blocks the synthesis or action of testosterone. Such therapies can, for example, block ligand receptor binding (e.g., binding of testosterone to its receptor), receptor signalling (e.g., signal transduction mediated by the binding of testosterone to its receptor), or the activity or expression of a downstream regulated gene.

Accordingly, the invention features a method for determining whether a compound, e.g., an anti-androgenic compound can be used to treat prostate cancer in a patient. The method includes:

a) obtaining a patient biological sample;

b) determining the normalized expression level of one or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130 in the patient sample;

c) comparing the normalized expression level of the selected one or more genes determined in step b) with the normalized expression level of the selected one or more genes in a non-prostate cancer biological sample; and

d) identifying that a compound can be used to treat prostate cancer in the patient when the normalized expression level of the selected one or more genes in the patient sample is greater than the normalized expression level of the selected one or more genes in the non-prostate cancer sample.

A non-prostate cancer biological sample is a sample of prostate cells, serum, interstitial fluid, blood, or seminal fluid from an individual which is not suffering from prostate cancer or a cell line, e.g., a prostate cell line which is not a prostate cancer cell line.

If the normalized expression of the selected one or more genes in the patient sample is not greater than the normalized expression of the selected one or more genes in the non-prostate cancer cell sample, it is less likely that an anti-androgenic therapy will be successful.

The invention also features a method for determining whether a compound, e.g., an anti-androgenic compound, can be used to treat prostate cancer in a patient, which method includes:

a) obtaining a patient biological sample;

b) determining the normalized expression level of one or more genes elected from the group consisting of SEQ ID NOS:1-40, 86-130 in the patient sample;

c) comparing the normalized expression level of the selected one or more genes determined in step b) with the normalized expression level of the selected one or more genes in a non-prostate cancer sample; and

d) identifying that a compound cannot be used to treat prostate cancer in the patient when the normalized expression level of the selected one or more genes in the patient sample is equal to or less than the normalized expression level of the selected one or more genes in the non-prostate cancer biological sample.

Generally, it is preferable to assess the expression of two, five or more, or even ten or more of the genes that are expressed at a higher level in prostate cancer cells treated with testosterone. Thus, it is preferable to assess the expression of a panel of differentially expressed genes.

In these assays, as well as other assays involving comparison of “normalized” expression levels, normalization refers to correcting the expression level of a differentially expressed gene by comparing its expression to the expression of a gene which is not differentially expressed in response to the selected compound, e.g., a gene that is not differentially expressed in prostate cancer cells in response to testosterone. Suitable genes for nromalization include housekeeping genes, e.g., the actin gene. This normalization allows one to compare the expression level in one sample, e.g., a patient sample, to another sample, e.g., a non-prostate cancer sample.

The expression level can be measured in a number of ways, including: measuring the mRNA encoded by each of the selected one or more genes; measuring the amount of protein encoded by each of the selected one or more genes; and measuring the activity of the protein encoded by each of the selected one or more genes.

Preferably, the expression level of several different selected genes from the group consisting of SEQ ID NOS:1-40, 86-130 are compared. For example, the expression of the gene of SEQ ID NO: 1 is compared in the two samples, and the expression of the gene of SEQ ID NO:2 is compared in the two samples. Preferably the selected genes are five or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130 or ten or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130.

The patient biological sample can be derived from, e,g., patient prostate cells, patient serum, patient interstitial fluid, patient blood, or patient seminal fluid. A sample of prostate cancer cells can be obtained by needle biopsy or other method used to biopsy or sample prostate cells.

As discussed above, the identified genes can also be used as markers to assess whether a prostate tumor has become refractory to an ongoing treatment (e.g., anti-androgenic treatment). When a tumor is no longer responding to a treatment the expression profile of the tumor cells is more closely resemble the expression profile of testosterone-treated prostate cancer cells than bicalutamide-treated prostate cancer cells.

Accordingly, the invention features methods for determining whether an anti-androgen treatment should be continued in a prostate cancer patient. One such method includes:

a) obtaining a patient biological sample;

b) determining the normalized expression level of one or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130 in the patient sample;

c) comparing the normalized expression level of the selected one or more genes determined in step b) with the normalized expression level of the selected one or more genes in a non-prostate cancer biological sample; and

d) discontinuing treatment when the normalized expression level of the selected one or more genes in the patient sample is greater than the normalized expression level of the selected one or more genes in the non-prostate cancer sample.

Another method for determining whether an anti-androgen treatment should be continued in a prostate cancer patient includes:

a) obtaining a patient biological sample;

b) determining the normalized expression level of one or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130 in the patient sample;

c) comparing the normalized expression level determined in step b) with the normalized expression level of the selected one or more genes in a non-prostate cancer biological sample; and

d) continuing treatment when the normalized expression of the selected one or more genes in the patient sample is equal to or less than the normalized expression of the selected one or more genes in the non-prostate cancer sample.

Preferably, the expression level of several different selected genes from the group consisting of SEQ ID NOS: 1-40, 86-130 are compared. For example, the expression of the gene of SEQ ID NO: 1 is compared in the two samples, and the expression of the gene of SEQ ID NO:2 is compared in the two samples. Preferably the selected genes are five or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130 or ten or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130.

The patient biological sample can be derived from, e,g., patient prostate cells, patient serum, patient interstitial fluid, patient blood, or patient seminal fluid.

In the context of clinical trials, test patients can be administered compounds suspected of being effective for treatment of prostate cancer. Control patients can be given a placebo. Tumor cells or biopsies can be drawn from each patient after a determined period of treatment. RNA can be isolated and subjected to expression analysis as described above.

Yet another method for determining whether a treatment should be continued in a prostate cancer patient includes:

a) obtaining a patient biological sample,

b) determining the normalized expression level of one or more genes selected from the group consisting of SEQ ID NOS: 41-85, 131-191 in the patient sample;

c) comparing the normalized expression level of the selected one or more genes determined in step b) with the normalized expression level of the selected one or more genes in a non-prostate cancer biological sample; and

d) discontinuing treatment when the normalized expression level of the selected one or more genes in the patient sample is less than or equal to the normalized expression level of the selected one or more genes in the non-prostate cancer sample.

Yet another method for determining whether a treatment should be continued in a prostate cancer patient includes:

a) obtaining a patient biological sample;

b) determining the normalized expression level of one or more genes selected from the group consisting of SEQ ID NOS:41-85, 131-191 in the patient sample;

c) comparing the normalized expression level determined in step b) with the normalized expression level of the selected one or more genes in a non-prostate cancer biological sample; and

d) continuing treatment when the normalized expression of the selected one or more genes in the patient sample is greater than the normalized expression of the selected one or more genes in the non-prostate cancer sample.

Preferably, the expression level of several different selected genes from the group consisting of SEQ ID NOS: 41-85, 131-191 are compared. For example, the expression of the gene of SEQ ID NO: 41 is compared in the two samples, and the expression of the gene of SEQ ID NO:42 is compared in the two samples. Preferably the selected genes are five or more genes selected from the group consisting of SEQ ID NOS:41-85, 131-191 or ten or more genes selected from the group consisting of SEQ ID NOS:41-85, 131-191.

The patient biological sample can be derived from, e,g., patient prostate cells, patient serum, patient interstitial fluid, patient blood, or patient seminal fluid.

In the context of clinical trials, test patients can be administered compounds suspected of being effective for treatment of prostate cancer. Control patients can be given a placebo. Tumor cells or biopsies can be drawn from each patient after a determined period of treatment. RNA can be isolated and subjected to expression analysis as described above.

The identified differentially expressed genes can also be used to determine whether a compound can be used to treat prostate cancer either generally or in a specific patient. In this approach the expression of one or more of the differentially expressed genes identified herein is measured in prostate cancer cells in the presence and absence of the candidate therapeutic compound.

If the gene(s) whose expression is assessed is of the class that is expressed at a higher level in the in the presence bicalutamide than in the absence of bicalutamide (SEQ ID NOS:41-85, 131-191), and it is observed that the gene(s) is more highly expressed in the presence of the candidate compound than in the absence of the candidate compound, then the candidate compound is likely to be a useful therapeutic agent. Thus, the invention features methods for determining whether a compound can be used to treat prostate cancer. The method includes:

a) measuring the expression level of one or more genes selected from the group consisting of SEQ ID NOS:41-85, 131-191 in a prostate cancer cell sample in the presence and absence of the compound; and

b) identifying the compound as useful for treating prostate cancer when the expression level of the selected one or more genes in the presence of the compound is greater than the expression level of the selected one or more genes in the absence of the compound.

If the gene(s) whose expression is assessed in the screening assay is of the class that is expressed at a higher level in the in the presence testosterone than in the absence of testosterone (SEQ ID NOS:1-40, 86-130), and it is observed that the gene(s) is not more highly expressed in the presence of the candidate compound than in the absence of the candidate compound, then the candidate compound is likely to be a useful therapeutic. Thus, the invention features a method for determining whether a compound can be used to treat prostate cancer, which method includes:

a) measuring the expression level of one or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130 in prostate cancer cell sample in the presence and absence of the compound; and

b) identifying the compound, as useful for treating prostate cancer when the expression level of the selected one or more genes in the presence of the compound is less than the expression level of the selected one or more genes in the absence of the compound.

Of course, the above-described screening method can entail measuring gene expression in a prostate cancer cell line or in prostate cancer cells isolated from a selected patient. Thus, the method can be used to identify therapeutic compounds which are expected to be generally useful as well and to identify therapeutic compounds which are expected to be beneficial for a particular patient.

It should also be recognized that there can be considerable benefit in assessing the expression of two or more, five or more, or even ten or more identified differentially expressed genes when screening candidate therapeutic agents.

IV. The Use of Differentially Expressed Genes in Diagnosing Prostate Cancer

A variety of methods can be employed for the diagnosis of prostate cancer. Such methods can, for example, utilize reagents such as fingerprint gene nucleotide sequences and antibodies directed against differentially expressed fingerprint gene products. Specifically, such reagents can be used, for example, for the detection of the detection of either over- or under-expression a differentially expressed gene or the presence of a mutation in a differentially expressed gene that is a target gene.

An identified differentially expressed gene which is expressed at a higher level in prostate cancer cells in the presence of testosterone than the absence of testosterone can be used as diagnostic markers. Thus, the invention features a method for determining whether a person has or is at risk of developing prostate cancer, which method includes:

A method for determining whether an individual has or at risk for developing prostate cancer, comprising:

a) obtaining a biological sample from the individual;

b) determining the normalized expression level of one or more genes selected from the group consisting of SEQ ID NOS:1-40, 86-130 in the individual sample;

c) comparing the normalized expression level of the selected one or more genes determined in step b) with the normalized expression level of the selected one or more genes in a non-prostate cancer biological sample; and

d) indentifying the individual as having or being at risk for developing prostate cancer when the normalized expression level of the selected one or more genes in the individual sample is greater than the normalized expression level of the selected one or more genes in the non-prostate cancer sample.

The methods described herein can be performed, for example, by utilizing pre-packaged diagnostic kits comprising at least one specific fingerprint gene nucleic acid or anti-fingerprint gene antibody reagent described herein, which can be conveniently used, e.g., in clinical settings, to diagnose patients exhibiting symptoms of prostate cancer.

a) Detection of Fingerprint Gene Nucleic Acids

DNA or RNA from the cell type or tissue to be analyzed can easily be isolated using procedures which are well known to those in the art. Diagnostic procedures can also be performed in situ directly upon tissue sections (fixed and/or frozen) of patient tissue obtained from biopsies or resections, such that no nucleic acid purification is necessary. Nucleic acid reagents such as those described above can be used as probes and/or primers for such in situ procedures (see, for example, Nuovo, 1992, PCR in situ Hybridization: Protocols and Applications, Raven Press, NY).

Fingerprint gene nucleotide sequences, either RNA or DNA, can, for example, be used in hybridization or amplification assays of biological samples to detect genes and expression patterns associated with prostate cancer. Such assays can include, but are not limited to, Southern or Northern analyses, single stranded conformational polymorphism analyses, in situ hybridization assays, and, polymerase chain reaction analyses. Such analyses can reveal both quantitative aspects of the expression pattern of the fingerprint gene, and qualitative aspects of the fingerprint gene expression and/or gene composition. That is, such techniques can include, for example, point mutations, insertions, deletions, chromosomal rearrangements, and/or activation or inactivation of gene expression.

Preferred diagnostic methods for the detection of fingerprint gene-specific nucleic acid molecules can involve for example, contacting and incubating nucleic acids, derived from the cell type or tissue being analyzed, with one or more labeled nucleic acid reagents under conditions favorable for the specific annealing of these reagents to their complementary sequences within the nucleic acid molecule or interest. Preferably, the lengths of these nucleic acid reagents are at least 15 to 30 nucleotides. After incubation, all non-annealed nucleic acids are removed from the nucleic acid:fingerprint RNA molecule hybrid. The presence of nucleic acids from the target tissue which have hybridized, if any such molecules exist, is then detected. Using such a detection scheme, the nucleic acid from the tissue or cell type of interest can be immobilized, for example, to a solid support such as a membrane, or a plastic surface such as that on a microtiter plate or polystyrene beads. In this case, after incubation, non-annealed, labeled fingerprint nucleic acid reagents are easily removed. Detection of the remaining, annealed, labeled nucleic acid reagents is accomplished using standard techniques well-known to those in the art.

Alternative diagnostic methods for the detection of fingerprint gene specific nucleic acid molecules can involve their amplification, e.g., by PCR (the experimental embodiment set forth in Mullis, 1987, U.S. Pat. No. 4,683,202), ligase chain reaction (Barany, 1991, Proc. Natl. Acad. Sci. USA 88:189-193), self sustained sequence replication (Guatelli et al., 1990, Proc. Natl. Acad. Sci. USA 87:1874-1878), transcriptional amplification system (Kwoh et al., 1989, Proc. Natl. Acad. Sci. USA 86:1173-1177), Q-Beta Replicase (Lizardi et al., 1988, Bio/Technology 6:1197), or any other nucleic acid amplification method, followed by the detection of the amplified molecules using techniques well known to those of skill in the art. These detection schemes are especially useful for the detection of nucleic acid molecules if such molecules are present in very low numbers.

In one embodiment of such a detection scheme, a cDNA molecule is obtained from an RNA molecule of interest (e.g., by reverse transcription of the RNA molecule into cDNA). Cell types or tissues from which such RNA can be isolated include any tissue in which wild type fingerprint gene is known to be expressed. A sequence within the cDNA is then used as the template for a nucleic acid amplification reaction, such as a PCR amplification reaction, or the like. The nucleic acid reagents used as synthesis initiation reagents (e.g., primers) in the reverse transcription and nucleic acid amplification steps of this method are chosen from among the fingerprint gene nucleic acid reagents. The preferred lengths of such nucleic acid reagents are at least 19-30 nucleotides. For detection of the amplified product, the nucleic acid amplification can be performed using radioactively or non-radioactively labeled nucleotides. Alternatively, enough amplified product can be made such that the product can be visualized by standard ethidium bromide staining or by utilizing any other suitable nucleic acid staining method.

In addition to methods which focus primarily on the detection of one nucleic acid sequence, fingerprint profiles can also be assessed in such detection schemes. Fingerprint profiles can be generated, for example, by utilizing a differential display procedure, as discussed above, Northern analysis, and/or RT-PCR. Any of the fingerprint gene sequences described above can be used as probes and/or PCR primers for the generation and corroboration of such fingerprint profiles.

b) Detection of Fingerprint Gene Products

Antibodies directed against wild-type or mutant fingerprint gene products can also be used in prostate cancer diagnostics and prognostics. Such diagnostic methods, can be used to detect abnormalities in the level of fingerprint gene protein expression, or abnormalities in the structure and/or tissue, cellular, or subcellular location of fingerprinting gene protein. Structural differences can include, for example, differences in the size, electronegativity, or antigenicity of the mutant fingerprint gene protein relative to the normal fingerprint gene protein.

Protein from the tissue or cell type to be analyzed can easily be isolated using techniques which are well known to those of skill in the art. The protein isolation methods employed herein can, for example, be such as those described in Harlow and Lane (Harlow and Lane, 1988, Antibodies: A Laboratory Manual , Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.), which is incorporated herein by reference in its entirety.

Preferred diagnostic methods for the detection of wild-type or mutant fingerprint gene peptide molecules can involve, for example, immunoassays wherein fingerprint gene peptides are detected by their interaction with an anti-fingerprint gene specific peptide antibody.

For example, antibodies, or fragments of antibodies, useful in the present invention can be used to quantitatively or qualitatively detect the presence of wild-type or mutant fingerprint gene peptides. This can be accomplished, for example, by immunofluorescence techniques employing a fluorescently labeled antibody (see below) coupled with light microscopic, flow cytometric, or fluorimetric detection. Such techniques are especially preferred if the fingerprint gene peptides are expressed on the cell surface.

The antibodies (or fragments thereof) useful in the present invention can, additionally, be employed histologically, as in immunofluorescence or immunoelectron microscopy, for in situ detection of target gene peptides. In situ detection can be accomplished by removing a histological specimen from a patient, and applying thereto a labeled antibody of the present invention. The antibody (or fragment) is preferably applied by overlaying the labeled antibody (or fragment) onto a biological sample. Through the use of such a procedure, it is possible to determine not only the presence of the fingerprint gene peptides, but also their distribution in the examined tissue. Using the present invention, those of ordinary skill will readily perceive that any of a wide variety of histological methods (such as staining procedures) can be modified in order to achieve such in situ detection.

Immunoassays for wild-type or mutant fingerprint gene peptides typically comprise incubating a biological sample, such as a biological fluid, a tissue extract, freshly harvested cells, or cells which have been incubated in tissue culture, in the presence of a detectably labeled antibody capable of identifying fingerprint gene peptides, and detecting the bound antibody by any of a number of techniques well-known in the art.

The biological sample can be brought in contact with and immobilized onto a solid phase support or carrier such as nitrocellulose, or other solid support which is capable of immobilizing cells, cell particles or soluble proteins. The support can then be washed with suitable buffers followed by treatment with the detectably labeled fingerprint gene specific antibody. The solid phase support can then be washed with the buffer a second time to remove unbound antibody. The amount of bound label on solid support can then be detected by conventional means.

Suitable solid phase supports or carriers include any support capable of binding an antigen or an antibody. Well-known supports or carriers include glass, polystyrene, polypropylene, polyethylene, dextran, nylon, amylases, natural and modified celluloses, polyacrylamides, gabbros, and magnetite. The nature of the carrier can be either soluble to some extent or insoluble for the purposes of the present invention. The support material can have virtually any possible structural configuration so long as the coupled molecule is capable of binding to an antigen or antibody. Thus, the support configuration can be spherical, as in a bead, or cylindrical, as in the inside surface of a test tube, or the external surface of a rod. Alternatively, the surface can be flat such as a sheet, test strip, etc. Preferred supports include polystyrene beads. Those skilled in the art will know many other suitable carriers for binding antibody or antigen, or will be able to ascertain the same by use of routine experimentation.

The binding activity of a given lot of anti-wild type or mutant fingerprint gene peptide antibody can be determined according to well-known methods. Those skilled in the art will be able to determine operative and optimal assay conditions for each determination by employing routine experimentation.

One of the ways in which the fingerprint gene peptide-specific antibody can be detectably labeled is by linking the same to an enzyme and use in an enzyme immunoassay (EIA). The enzyme which is bound to the antibody will react with an appropriate substrate, preferably a chromogenic substrate, in such a manner as to produce a chemical moiety which can be detected, for example, by spectrophotometric, fluorimetric or by visual means. Enzymes which can be used to detectably label the antibody include, but are not limited to, malate dehydrogenase, staphylococcal nuclease, delta-5-steroid isomerase, yeast alcohol dehydrogenase, alpha-glycerophosphate, dehydrogenase, triose phosphate isomerase, horseradish peroxidase, alkaline phosphatase, asparaginase, glucose oxidase, beta-galactosidase, ribonuclease, urease, catalase, glucose-6-phosphate dehydrogenase, glucoamylase and acetylcholinesterase. The detection can be accomplished by colorimetric methods which employ a chromogenic substrate for the enzyme. Detection can also be accomplished by visual comparison of the extent of enzymatic reaction of a substrate in comparison with similarly prepared standards.

Detection can also be accomplished using any of a variety of other immunoassays. For example, by radioactively labeling the antibodies or antibody fragments, it is possible to detect fingerprint gene wild type or mutant peptides through the use of a radioimmunoassay (RIA). The radioactive isotope can be, detected by such means as the use of a gamma counter or a scintillation counter or by autoradiography.

It is also possible to label the antibody with a fluorescent compound. When the fluorescently labeled antibody is exposed to light of the proper wave length, its presence can then be detected due to fluorescence. Among the most commonly used fluorescent labeling compounds are fluorescein isothiocyanate, rhodamine, phycoerythrin, phycocyanin, allophycocyanin, o-phthaldehyde and fluorescamine.

The antibody can also be detectably labeled using fluorescence emitting metals such as 152 Eu, or others of the lanthanide series. These metals can be attached to the antibody using such metal chelating groups as diethylenetriaminepentacetic acid (DTPA) or ethylenediaminetetraacetic acid (EDTA).

The antibody also can be detectably labeled by coupling it to a chemiluminescent compound. The presence of the chemiluminescent-tagged antibody is then determined by detecting the presence of luminescence that arises during the course of a chemical reaction. Examples of particularly useful chemiluminescent labeling compounds are luminol, isoluminol, theromatic acridinium ester, imidazole, acridinium salt and oxalate ester.

Likewise, a bioluminescent compound can be used to label the antibody of the present invention. Bioluminescence is a type of chemiluminescence found in biological systems in, which a catalytic protein increases the efficiency of the chemiluminescent reaction. The presence of a bioluminescent protein is determined by detecting the presence of luminescence. Important bioluminescent compounds for purposes of labeling are luciferin, luciferase and aequorin.

V. Characterization of Differentially Expressed Genes

Differentially expressed genes can be further characterized by using techniques known to those skilled in the art.

Such characterization can yield information regarding the biological function of the identified genes. An assessment of the biological function of the differentially expressed genes, in addition, will allow for their designation as target and/or fingerprint genes.

Specifically, any of the differentially expressed genes whose further characterization indicates that a modulation of the gene's expression or a modulation of the gene product's activity can reduce symptoms of prostate cancer are designated “target genes.” Such target genes and target gene products can be used to identify therapeutics. A differentially expressed genes whose further characterization indicates that it does not influence growth or viability of prostate cancer cells, but whose expression pattern contributes to a gene expression “fingerprint” pattern correlative of, for example, the effectiveness of a drug is designated a “fingerprint gene.” Such genes can be used as diagnostic markers and as markers for assessing the effectiveness or potential effectiveness of a therapeutic agent.

A variety of techniques can be utilized to further characterize the identified genes. First, the nucleotide sequence of the identified genes, which can be obtained by utilizing standard techniques well known to those of skill in the art, can be used to further characterize such genes. For example, the sequence of the identified genes can reveal homologies to one or more known sequence motifs which can yield information regarding the biological function of the identified gene product.

Second, an analysis of the tissue and/or cell type distribution of the mRNA produced by the identified genes can be conducted, utilizing standard techniques well known to those of skill in the art. Such techniques can include, for example, Northern analyses, RT-coupled PCR and RNase protection techniques. Such analyses provide information as to whether the identified genes are expressed in tissues expected to contribute to prostate cancer. Such analyses can also provide quantitative information regarding steady state mRNA regulation, yielding data concerning which of the identified genes exhibits a high level of regulation in, preferably, tissues which can be expected to contribute to prostate cancer. Additionally, standard in situ hybridization techniques can be utilized to provide information regarding which cells within a given tissue express the identified gene. Such an analysis can provide information regarding the biological function of an identified gene in instances wherein only a subset of the cells within the tissue is thought to be relevant to prostate cancer.

Third, the sequences of the identified genes can be used, utilizing standard techniques, to place the genes onto genetic maps, e.g., mouse (Copeland and Jenkins 1991, Trends in Genetics 7:113-118) and human genetic maps (Cohen et al., 1993, Nature 366:698-701). Such mapping information can yield information regarding the genes' importance to human disease by, for example, identifying genes which map within genetic regions to which predisposition to prostate cancer also maps.

Fourth, the biological function of the identified genes can be more directly assessed by utilizing relevant in vivo and in vitro systems. In vivo systems can include, but are not limited to, animal systems which naturally exhibit symptoms of prostate cancer or ones which have been engineered to exhibit such symptoms.

The role of identified gene products can be determined by transfecting cDNAs encoding these gene products into appropriate cell lines, such as, for example, a prostate cancer cell line and analyzing the effect of the gene product on cell growth.

In further characterizing the biological function of the identified genes, the expression of these genes can be modulated within the in vivo and/or in vitro systems, i.e., either over-expressed or under-expressed, and the subsequent effect on the system then assayed. Alternatively, the activity of the product of the identified gene can be modulated by either increasing or decreasing the level of activity in the in vivo and/or in vitro system of interest, and assessing the effect of such modulation.

The information obtained through such characterizations can suggest relevant methods for the treatment of prostate cancer. For example, treatment can include a modulation of gene expression and/or gene product activity. Characterization procedures such as those described herein can indicate where such modulation should involve an increase or a decrease in the expression or activity of the gene or gene product of interest.

a) Expression of Proteins Encoded by Differentially Expressed Genes

A variety of host-expression vector systems can be utilized to express the differentially expressed gene coding sequences of the invention. Such host-expression systems represent vehicles by which the coding sequences of interest can be produced and subsequently purified, but also represent cells which can, when transformed or transfected with the appropriate nucleotide coding sequences, exhibit the differentially expressed gene protein in situ. These include but are not limited to microorganisms such as bacteria (e.g., E. coli and B. subtilis ) transformed with recombinant bacteriophage DNA, plasmid DNA or cosmid DNA expression vectors containing differentially expressed gene protein coding sequences; yeast (e.g., Saccharomyces and Pichia) transformed with recombinant yeast expression vectors containing the differentially expressed gene protein coding sequences; insect cell systems infected with recombinant virus expression vectors (e.g., baculovirus) containing the differentially expressed gene protein coding sequences; plant cell systems infected with recombinant virus expression vectors (e.g., cauliflower mosaic virus, CaMV; tobacco mosaic virus, TMV) or transformed with recombinant plasmid expression vectors (e.g., Ti plasmid) containing differentially expressed gene protein coding sequences; or mammalian cell systems (e.g., COS, CHO, BHK, 293, 3T3) harboring recombinant expression constructs containing promoters derived from the genome of mammalian cells (e.g., metallothionein promoter) or from mammalian viruses (e.g., the adenovirus late promoter; the vaccinia virus 7.5K promoter).

In bacterial systems, a number of expression vectors can be advantageously selected depending upon the use intended for the differentially expressed gene protein being expressed. For example, when a large quantity of such a protein is to be produced, for the generation of antibodies or to screen peptide libraries, for example, vectors which direct the expression of high levels of fusion protein products that are readily purified can be desirable. Such vectors include, but are not limited, to the E. coli expression vector pUR278 (Ruther et al., 1983, EMBO J. 2:1791), in which the differentially expressed-gene protein coding sequence can be ligated individually into the vector in frame with the lacZ coding region so that a fusion protein is produced; pIN vectors (Inouye & Inouye, 1985, Nucleic Acids Res. 13:3101-3109; Van Heeke & Schuster, 1989, J. Biol. Chem. 264:5503-5509); and the like. pGEX vectors can also be used to express foreign polypeptides as fusion proteins with glutathione S-transferase (GST). In general, such fusion proteins are soluble and can easily be purified from lysed cells by adsorption to glutathione-agarose beads followed by elution in the presence of free glutathione. The pGEX vectors are designed to include thrombin or factor Xa protease cleavage sites so that the cloned target gene protein can be released from the GST moiety.

In an insect system, Autographa californica nuclear polyhedrosis virus (AcNPV) is used as a vector to express foreign genes. The virus grows in Spodoptera frugiperda cells. The differentially expressed gene coding sequence can be cloned individually into non-essential regions (for example the polyhedrin gene) of the virus and placed under control of an AcNPV promoter (for example, the polyhedrin promoter). Successful insertion of differentially expressed gene coding sequence will result in inactivation of the polyhedrin gene and production of non-occluded recombinant virus (i.e., virus lacking the proteinaceous coat coded for by the polyhedrin gene). These recombinant viruses are then used to infect Spodoptera frugiperda cells in which the inserted gene is expressed (e.g., see Smith et al., 1983, J. Viol. 46:584; Smith, U.S. Pat. No. 4,215,051).

In mammalian host cells, a number of viral-based expression systems can be utilized. In cases where an adenovirus is used as an expression vector, the differentially expressed gene coding sequence of interest can be ligated to an adenovirus transcription/translation control complex, e.g., the late promoter and tripartite leader sequence. This chimeric gene can then be inserted in the adenovirus genome by in vitro or in vivo recombination. Insertion in a non-essential region of the viral genome (e.g., region E1 or E3) will result in a recombinant virus that is viable and capable of expressing differentially expressed gene protein in infected hosts (e.g., see Logan & Shenk, 1984, Proc. Natl. Acad. Sci. USA 81:3655-3659). Specific initiation signals can also be required for efficient translation of inserted differentially expressed gene coding sequences. These signals include the ATG initiation codon and adjacent sequences. In cases where an entire identified gene, including its own initiation codon and adjacent sequences, is inserted into the appropriate expression vector, no additional translational control signals can be needed. However, in cases where only a portion of the identified coding sequence is inserted, exogenous translational control signals, including, perhaps, the ATG initiation codon, must be provided. Furthermore, the initiation codon must be in phase with the reading frame of the desired coding sequence to ensure translation of the entire insert. These exogenous translational control signals and initiation codons can be of a variety of origins, both natural and synthetic. The efficiency of expression can be enhanced by the inclusion of appropriate transcription enhancer elements, transcription terminators, etc., (see Bittner et al., 1987, Methods in Enzymol. 153:516-544).

In addition, a host cell strain can be chosen which modulates the expression of the inserted sequences, or modifies and processes the gene product in the specific fashion desired. Such modifications (e.g., glycosylation) and processing (e.g., cleavage) of protein products can be important for the function of the protein. Different host cells have characteristic and specific mechanisms for the post-translational processing and modification of proteins. Appropriate cell lines or host systems can be chosen to ensure the correct modification and processing of the foreign protein expressed. To this end, eukaryotic host cells which possess the cellular machinery for proper processing of the primary transcript, glycosylation, and phosphorylation of the gene product can be used. Such mammalian host cells include but are not limited to CHO, VERO, BHK, HeLa, COS, MDCK, 293, 3T3, W138, etc.

For long-term, high-yield production of recombinant proteins, stable expression is preferred. For example, cell lines which stably express the differentially expressed gene protein can be engineered. Rather than using expression vectors which contain viral origins of replication, host cells can be transformed with DNA controlled by appropriate expression control elements (e.g., promoter, enhancer, sequences, transcription terminators, polyadenylation sites, etc.), and a selectable marker. Following the introduction of the foreign DNA, engineered cells can be allowed to grow for 1-2 days in an enriched media, and then are switched to a selective media. The selectable marker in the recombinant plasmid confers resistance to the selection and allows cells to stably integrate the plasmid into their chromosomes and grow to form foci which in turn can be cloned and expanded into cell lines. This method can advantageously be used to engineer cell lines which express the identified gene protein. Such engineered cell lines can be particularly useful in screening and evaluation of compounds that affect the endogenous activity of the differentially expressed gene protein.

A number of selection systems can be used, including, but not limited to, the herpes simplex virus thymidine kinase (Wigler et al., 1977, Cell 11:223), hypoxanthine-guanine phosphoribosyltransferase (Szybalska & Szybalski, 1962, Proc. Natl. Acad. Sci. USA 48:2026), and adenine phosphoribosyltransferase (Lowy et al., 1980, Cell 22:817) genes in tk − , hgprt − or aprt − cells, respectively. Also, antimetabolite resistance can be used as the basis of selection for dhfr, which confers resistance to methotrexate (Wigler et al., 1980, Natl. Acad. Sci. USA 77:3567; O'Hare et al., 1981, Proc. Natl. Acad. Sci. USA 78:1527); gpt, which confers resistance to mycophenolic acid (Mulligan & Berg, 1981, Proc. Natl. Acad. Sci. USA 78:2072); neo, which confers resistance to the aminoglycoside G-418 (Colberre-Garapin et al., 1981, J. Mol. Biol. 150:1); and hygro, which confers resistance to hygromycin (Santerre et al., 1984, Gene 30:147) genes.

An alternative fusion protein system allows for the ready purification of non-denatured fusion proteins expressed in human cell lines (Janknecht et al., 1991, Proc. Natl. Acad. Sci. USA 88:8972-8976). In this system, the gene of interest is subcloned into a vaccinia recombination plasmid such that the gene's open reading frame is translationally fused to an amino-terminal tag consisting of six histidine residues. Extracts from cells infected with recombinant vaccinia virus are loaded onto ni2+ nitriloacetic acid-agarose columns and histidine-tagged proteins are selectively eluted with imidazole-containing buffers.

When used as a component in assay systems such as that described herein, the differentially expressed gene protein can be labeled, either directly or indirectly, to facilitate detection of a complex formed between the differentially expressed gene protein and a test substance. Any of a variety of suitable labeling systems can be used including but not limited to radioisotopes such as 125 I; enzyme labeling systems that generate a detectable colorimetric signal or light when exposed to substrate; and fluorescent labels.

Where recombinant DNA technology is used to produce the differentially expressed gene protein for such assay systems, it can be advantageous to engineer fusion proteins that can facilitate labeling, solubility, immobilization and/or detection.

Indirect labeling involves the use of a third protein, such as a labeled antibody, which specifically binds to either a differentially expressed gene product. Such antibodies include but are not limited to polyclonal, monoclonal, chimeric, single chain, Fab fragments and fragments produced by a Fab expression library.

b) Antibodies Specific for Differentially Expressed Gene Products

Described below are methods for the production of antibodies capable of specifically recognizing one or more differentially expressed gene products. Such antibodies can include, but are not limited to polyclonal antibodies, monoclonal antibodies (mAbs), humanized or chimeric antibodies, single chain antibodies, Fab fragments, F(ab′) 2 fragments, fragments produced by a FAb expression library, anti-idiotypic (anti-Id) antibodies, and epitope-binding fragments of any of the above. Such antibodies can be used, for example, in the detection of a fingerprint or target gene product in a biological sample, or, alternatively, as a method for the inhibition of abnormal target gene activity. Thus, such antibodies can be utilized as treatment methods, and/or can be used as pat of diagnostic techniques whereby patients can be tested for abnormal levels of fingerprint or target gene proteins, or for the presence of abnormal forms of the such proteins.

For the production of antibodies to a differentially expressed gene, various host animals can be immunized by injection with a differentially expressed gene protein, or a portion thereof. Such host animals can include but are not limited to rabbits, mice, and rats, to name but a few. Various adjuvants can be used to increase the immunological response, depending on the host species, including but not limited to Freund's (complete and incomplete), mineral gels such as aluminum hydroxide, surface active substances such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanin, dinitrophenol, and potentially useful human adjuvants such as BCG (Bacilli Calmette-Guerin) and Corynebacterium parvum.

Polyclonal antibodies are heterogeneous populations of antibody molecules derived from the sera of animals immunized with an antigen, such as target gene product, or an antigenic functional derivative thereof. For the production of polyclonal antibodies, host animals such as those described above, can be immnunized by injection with differentially expressed gene product supplemented with adjuvants as also described above.

Monoclonal antibodies, which are homogeneous populations of antibodies to a particular antigen, can be obtained by any technique which provides for the production of antibody molecules by continuous cell lines in culture. These include, but are not limited to the hybridoma technique of Kohler and Milstein, (1975, Nature 256:495-497; and U.S. Pat. No. 4,376,110), the human B-cell hybridoma technique (Kosbor et al., 1983, Immunology Today 4:72; Cole et al., 1983, Proc. Natl. Acad. Sci. USA 80:2026-2030), and the BV-hybridoma technique (Cole et al., 1985, Monoclonal Antibodies And Cancer Therapy , Alan R. Liss, Inc., pp. 77-96). Such antibodies can be of any immunoglobulin class including IgG, IgM, IgE, IgA, IgD and any subclass thereof. The hybridoma producing the mAb of this invention can be cultivated in vitro or in vivo. Production of high titers of mAbs in vivo makes this the presently preferred method of production.

In addition, techniques developed for the production of “chimeric antibodies” (Morrison et al., 1984, Proc. Natl. Acad. Sci., 81:6851-6855; Neuberger et al., 1984, Nature, 312:604-608; Takeda et al., 1985, Nature, 314:452-454; U.S. Pat. No. 4,816,567) by splicing the genes from a mouse antibody molecule of appropriate antigen specificity together with genes from a human antibody molecule of appropriate biological activity can be used. A chimeric antibody is a molecule in which different portions are derived from different animal species, such as those having a variable region derived from a murine mAb and a human immunoglobulin constant region.

Alternatively, techniques described for the production of single chain antibodies (U.S. Pat. No. 4,946,778; Bird, 1988, Science 242:423-426; Huston et al., 1988, Proc. Natl. Acad. Sci. USA 85:5879-5883; and Ward et al., 1989, Nature 334:544-546) and for making humanized monoclonal antibodies (U.S. Pat. No. 5,225,539, which is incorporated herein by reference in its entirety) can be utilized to produce anti-differentially expressed gene product antibodies.

Antibody fragments which recognize specific epitopes can be generated by known techniques. For example, such fragments include but are not limited to: the F(ab′) 2 fragments which can be produced by pepsin digestion of the antibody molecule and the Fab fragments which can be generated by reducing the disulfide bridges of the F(ab′) 2 fragments. Alternatively, Fab expression libraries can be constructed (Huse et al., 1989, Science, 246:1275-1281) to allow rapid and easy identification of monoclonal Fab fragments with the desired specificity.

c) In vitro and In vivo Systems for Gene Characterization

Described below are in vitro and in vivo systems which can be used to further characterize differentially Expressed Genes. These system can also be used as part of screening strategies designed to identify compounds which are capable of preventing and/or ameliorating symptoms of prostate cancer. Thus, these systems can be used to identify drugs, pharmaceuticals, therapies and interventions which can be effective in treating prostate cancer and to determine the in vivo efficacy of drugs, pharmaceuticals, therapies and interventions.

1) In Vitro Systems

Cells that contain and express target gene sequences and exhibit cellular phenotypes associated with prostate cancer, can be utilized to identify compounds that exhibit an ability to prevent and/or treat prostate cancer.

Further, the fingerprint pattern of gene expression of cells of interest can be analyzed and compared to the normal fingerprint pattern. Those compounds which cause cells exhibiting cellular phenotypes of prostate cancer to produce a fingerprint pattern more closely resembling a normal fingerprint pattern for the cell of interest can be considered candidates for further testing regarding an ability to ameliorate the symptoms of prostate cancer.

Cells which will be utilized for such assays can, for example, include LNCap cells. In addition, purified primary or secondary tumor cells derived from either transgenic or non-transgenic tumor cells can be used.

Further, cells which can be used for such assays can also include recombinant, transgenic cell lines. While primary cultures derived from the metastasis in transgenic animals can be utilized, the generation of continuous cell lines is preferred. For examples of techniques which can be used to derive a continuous cell line from a transgenic animal, see Small et al., 1985, Mol. Cell Biol. 5:642-648.

Alternatively, cells of a cell type known to be involved in prostate cancer can be transfected with sequences capable of increasing or decreasing the amount of target gene expression within the cell. For examples target gene sequences can be introduced into, and over expressed in, the genome of the cell of interest, or, if endogenous target gene sequences are present, they can either be overexpressed or, alternatively, be disrupted in order to underexpress or inactivate target gene expression.

In order to overexpress a target gene sequence, the coding portion of the target gene sequence can be ligated to a regulatory sequence which is capable of driving gene expression in the cell type of interest. Such regulatory regions will be well known to those of skill in the art.

For under expression of an endogenous target gene sequence, such a sequence can be isolated and engineered such that when reintroduced into the genome of the cell type of interest, the endogenous target gene alleles will be inactivated. Preferably, the engineered target gene sequence is introduced via gene targeting such that the endogenous target sequence is disrupted upon integration of the engineered target gene sequence into the cell's genome.

Transfection of target gene sequence nucleic acid can be accomplished by utilizing standard techniques (see, e.g., Ausubel, supra). Transfected cells should be evaluated for the presence of the recombinant target gene sequences, for expression and accumulation of target gene mRNA, and for the presence of recombinant target gene protein production. In instances wherein a decrease in target gene expression is desired, standard techniques can be used to demonstrate whether a decrease in endogenous target gene expression and/or in target gene product production is achieved.

2) In Vivo Systems

In vivo systems of prostate cancer can be either non-recombinant animals or recombinantly engineered transgenic animals. Such models may be generated, for example, by introducing tumor cells into syngeneic mice using techniques such as implanting prostatic cancer cells into the prostate gland. After an appropriate period of time, the tumors which result from these injections can be counted and analyzed.

For the generation of animal models of prostate cancer, cells derived from, for example, a prostate cancer cell line may be implanted into the prostate of an animal and the resulting tumors may be analyzed and compared to, for example, normal tissue.

The role of identified gene products (i.e., those encoded by target genes) can be determined by transfecting cDNAs encoding such gene products into the appropriate cell line and analyzing its effect on the cells' ability to induce prostate cancer in animal models such as these. The role of the identified gene products may be further analyzed by, for example, culturing cells derived from the tumors which develop in the animal models, introducing these cultured cells into animals, and subsequently measuring the level of identified gene product present in the resulting tumor cells. In this manner, cell line variants are developed which can be useful in analyzing the role of quantitative and/or qualitative differences in the expression of the identified genes on the cells' ability to induce prostate cancer.

Recombinant animal models for prostate cancer can be engineered by utilizing, for example, target gene sequences such as those described herein in conjunction with techniques for producing transgenic animals that are well known to those of skill in the art. For example, target gene sequences can be introduced into, and overexpressed in, the genome of the animal of interest, or, if endogenous target gene sequences are present, they can either be overexpressed or, alternatively, can be disrupted in order to underexpress or inactivate target gene expression.

In order to overexpress a target gene sequence, the coding portion of the target gene sequence can be ligated to a regulatory sequence which is capable of driving gene expression in the animal and cell type of interest. Such regulatory regions will be well known to those of skill in the art.

In order to obtain underexpression of an endogenous target gene sequence, such a sequence can be introduced into the genome of the animal of interest such that the endogenous target gene alleles will be inactivated. Preferably, an engineered sequence comprising at least part of the target gene sequence is utilized and is introduced, via gene targeting, such that the endogenous target sequence is disrupted upon integration of the engineered target gene sequence into the animal's genome.

Animals of any species, including, but not limited to, mice, rats, rabbits, guinea pigs, pigs, micro-pigs, goats, and-non-human primates, e.g., baboons, monkeys, and chimpanzees can be used to generate animal models of prostate cancer.

Any technique known in the art can be used to introduce a target gene transgene into animals to produce the founder lines of transgenic animals. Such techniques include, but are not limited to pronuclear microinjection (Hoppe and Wagner, 1989, U.S. Pat. No. 4,873,191); retrovirus mediated gene transfer into germ lines (Van der Putten et al., 1985, Proc. Natl. Acad. Sci., USA 82:6148-6152); gene targeting in embryonic stem cells (Thompson et al., 1989, Cell 56:313-321); electroporation of embryos (Lo, 1983, Mol Cell. Biol. 3:1803-1814); and sperm-mediated gene transfer (Lavitrano et al., 1989, Cell 57:717-723).

The present invention provides for transgenic animals that carry the transgene in all their cells, as well as animals which carry the transgene in some, but not all their cells, i.e., mosaic animals. The transgene can be integrated, either as a single transgene or in concatamers, e.g., head-to-head tandems or head-to-tail tandems. The transgene can also be selectively introduced into and activated in a particular cell type using known techniques (Lasko et al., 1992, Proc. Natl. Acad. Sci. USA 89:6232-6236). The regulatory sequences required for depend upon the particular cell type of interest, and will be apparent to those of skill in the art.

When it is desired that the target gene transgene be integrated into the chromosomal site of the endogenous target gene, gene targeting is preferred. Briefly, when such a technique is to be utilized, vectors containing some nucleotide sequences homologous to the endogenous target gene of interest are designed for the purpose of integrating, via homologous recombination with chromosomal sequences, into and disrupting the function of, the nucleotide sequence of the endogenous target gene. The transgene can also be selectively introduced into a particular cell type, thus inactivating the endogenous gene of interest in only that cell type, by following, for example, the teaching of Gu et al. (1994, Science 265:103-106). The regulatory sequences required for such a cell-type specific inactivation will depend upon the particular cell type of interest, and will be apparent to those of skill in the art.

Once transgenic animals have been generated, the expression of the recombinant target gene and protein can be assayed utilizing standard techniques. Initial screening can be accomplished by Southern blot analysis or PCR techniques to analyze animal tissues to assay whether integration of the transgene has taken place. The level of mRNA expression of the transgene in the tissues of the transgenic animals can also be assessed using techniques which include, but are not limited to, Northern blot analysis of tissue samples obtained from the animal, in situ hybridization analysis, and RT-coupled PCR. Samples of target gene-expressing tissue, can also be evaluated immunocytochemically using antibodies specific for the transgenic product of interest.

The target gene transgenic animals that express target gene mRNA or target gene transgene peptide (detected immunocytochemically, using antibodies directed against target gene product epitopes) at easily detectable levels should then be further evaluated to identify those animals which display prostate cancer characteristics.

Additionally, specific cell types within the transgenic animals can be analyzed for cellular phenotypes characteristic of prostate cancer. Such cellular phenotypes can include, for example, differential gene expression characteristic of prostate cancer cells. Further, such cellular phenotypes can include as assessment of a particular cell type fingerprint profile and its comparison to known fingerprint profiles of the particular cell type in animals exhibiting prostate cancer. Such transgenic animals serve as suitable model systems for prostate cancer.

Once target gene transgenic founder animals are produced (i.e., those animals which express target gene proteins in cells or tissues of interest, and which, preferably, exhibit prostate cancer characteristics), they can be bred, inbred, outbred, or crossbred to produce colonies of the particular animal. Examples of such breeding strategies include but are not limited to: outbreeding of founder animals with more than one integration site in order to establish separate lines: inbreeding of separate lines in order to produce compound target gene transgenics that express the target gene transgene of interest at higher levels because of the effects of additive expression of each target gene transgene; crossing of heterozygous transgenic animals to produce animals homozygous for a given integration site in order to both augment expression and eliminate the possible need for screening of animals by DNA analysis; crossing of separate homozygous lines to produce compound heterozygous or homozygous lines; breeding animals to different inbred genetic backgrounds so as to examine effects of modifying alleles on expression of the target gene transgene and the development of symptoms of prostate cancer. One such approach is to cross the target gene transgenic founder animals with a wild-type strain to produce an F1 generation that exhibits symptoms of prostate cancer. The F1 generation can then be inbred in order to develop a homozygous line, if it is found that homozygous target gene transgenic animals are viable.

d) Identification of Compounds that Interact with a Target Gene Product

The following assays are designed to identify compounds that bind to target gene products, compounds that bind to other cellular proteins that interact with a target gene product, and compounds that interfere with the interaction of the target gene product with other cellular proteins.

Such compounds can include, but are not limited to, other cellular proteins. Specifically, such compounds can include, but are not limited to, peptides, such as, for example, soluble peptides, including, but not limited to Ig-tailed fusion peptides, comprising extracellular portions of target gene product transmembrane receptors, and members of random peptide libraries (see, e.g., Lam et al., 1991, Nature 354:82-84; Houghton et al., 1991, Nature 354:84-86), made of D-and/or L-configuration amino acids, phosphopeptides (including, but not limited to, members of random or partially degenerate phosphopeptide libraries; see, e.g., Songyang et al., 1993, Cell 72:767-778), antibodies (including, but not limited to, polyclonal, monoclonal, humanized, anti-idiotypic, chimeric or single chain antibodies, and FAb, F(ab′) 2 and FAb expression libary fragments, and epitope-binding fragments thereof), and small organic or inorganic molecules.

Compounds identified via assays such as those described herein can be useful, for example, in elaborating the biological function of the target gene product, and for ameliorating symptoms of prostate cancer. For example, in instances in which prostate cancer is associated with lower expression of a target gene product, and/or lower target gene product activity, compounds that interact with the target gene product can include ones which increase the activity of the target gene product. Such compounds would bring about an effective increase in the level of target gene activity, thus ameliorating symptoms of prostate cancer. Conversely, in instances in which a mutation within a target gene cause aberrant target gene products to be made which have a deleterious effect that leads to prostate cancer, compounds that bind target gene product can be identified that inhibit the activity of the target gene product.

1) Screening Assays for Compounds and Cellular Proteins that Bind to a Target Gene Product

In vitro systems can be designed to identify compounds capable of binding the target gene products of the invention. Compounds identified can be useful, for example, in modulating the activity of wild type and/or mutant target gene products, preferably mutant target gene proteins, can be useful in elaborating the biological function of the target gene product, can be utilized in screens for identifying compounds that disrupt normal target gene interactions, or can in themselves disrupt such interactions.

The principle of the assays used to identify compounds that bind to the target gene product involves preparing a reaction mixture of the target gene protein and the test compound under conditions and for a time sufficient to allow the two components to interact and bind, thus forming a complex which can be removed and/or detected in the reaction mixture. These assays can be conducted in a variety of ways. For example, one method to conduct such an assay would involve anchoring target gene product or the test substance onto a solid phase and detecting target gene product/test compound complexes anchored on the solid phase at the end of the reaction. In one embodiment of such a method, the target gene product can be anchored onto a solid surface, and the test compound, which is not anchored, can be labeled, either directly or indirectly.

In practice, microtiter plates can conveniently be utilized as the solid phase. The anchored component can be immobilized by non-covalent or covalent attachments. Non-covalent attachment can be accomplished by simply coating the solid surface with a solution of the protein and drying. Alternatively, an immobilized antibody, preferably a monoclonal antibody, specific for the protein to be immobilized can be used to anchor the protein to the solid surface. The surfaces can be prepared in advance and stored.

In order to conduct the assay, the nonimmobilized component is added to the coated surface containing the anchored component. After the reaction is complete, unreacted components are removed (e.g., by washing) under conditions such that any complexes formed will remain immobilized on the solid surface. The detection of complexes anchored on the solid surface can be accomplished in a number of ways. Where the previously immobilized component is pre-labeled, the detection of label immobilized on the surface indicates that complexes were formed. Where the previously nonimmobilized component is not pre-labeled, an indirect label can be used to detect complexes anchored on the surface; e.g., using a labeled antibody specific for the immobilized component (the antibody, in turn, can be directly labeled or indirectly labeled with a labeled anti-Ig antibody).

Alternatively, a reaction can be conducted in a liquid phase, the reaction products separated from unreacted components, and complexes detected; e.g., using an immobilized antibody specific for target gene or the test compound to anchor any complexes formed in solution, and a labeled antibody specific for the other component of the possible complex to detect anchored complexes.

Any method suitable for detecting protein-protein interactions can be employed for identifying novel target product-cellular or extracellular protein interactions. In such a case, the target gene serves as the known “bait” gene.

2) Assays for Compounds that Interfere with the Binding of a Target Gene Product to a Second Cellular Protein

The target gene products of the invention can, in vivo, interact with one or more cellular or extracellular macromolecules, such as proteins. For the purposes of this discussion, such cellular and extracellular macromolecules are referred to herein as “binding partners.” Compounds that disrupt such interactions can be useful in regulating the activity of the target gene product, especially mutant target gene products. Such compounds can include, but are not limited to molecules such as antibodies, peptides, and small molecules.

The basic principle of the assay systems used to identify compounds that interfere with the interaction between the target gene product and its cellular or extracellular binding partner or partners involves preparing a reaction mixture containing the target gene product, and the binding partner under conditions and for a time sufficient to allow the two products to interact and bind, thus forming a complex. In order to test a compound for inhibitory activity, the reaction mixture is prepared in the presence and absence of the test compound. The test compound can be initially included in the reaction mixture, or can be added at a time subsequent to the addition of target gene and its cellular or extracellular binding partner. Control reaction mixtures are incubated without the test compound or with a placebo. The formation of any complexes between the target gene product and the cellular or extracellular binding partner is then detected. The formation of a complex in the control reaction, but not in the reaction mixture containing the test compound, indicates that the compound interferes with the interaction of the target gene product and the interactive binding partner. Additionally, complex formation within reaction mixtures containing the test compound and normal target gene product can also be compared to complex formation within reaction mixtures containing the test compound and mutant target gene product. This comparison can be important in those cases wherein it is desirable to identify compounds that disrupt interactions of mutant but not normal target gene products.

The assay for compounds that interfere with the interaction of the target gene products and binding partners can be conducted in a heterogeneous or homogeneous format. Heterogeneous assays involve anchoring either the target gene product or the binding partner onto a solid phase and detecting complexes anchored on the solid phase at the end of the reaction. In homogeneous assays, the entire reaction is carried out in a liquid phase. In either approach, the order of addition of reactants can be varied to obtain different information about the compounds being tested. For example, test compounds that interfere with the interaction between the target gene products and the binding partners, e.g., by competition, can be identified by conducting the reaction in the presence of the test substance; i.e., by adding the test substance to the reaction mixture prior to or simultaneously with the target gene product and interactive cellular or extracellular binding partner. Alternatively, test compounds that disrupt preformed complexes, e.g., compounds with higher binding constants that displace one of the components from the complex, can be tested by adding the test compound to the reaction mixture after complexes have been formed. The various formats are described briefly below.

In a heterogeneous assay system, either the target gene product or the interactive cellular or extracellular binding partner, is anchored onto a solid surface, while the non-anchored species is labeled, either directly or indirectly. In practice, microtitre plates are conveniently utilized. The anchored species can be immobilized by non-covalent or covalent attachments. Non-covalent attachment can be accomplished simply by coating the solid surface with a solution of the target gene product or binding partner and drying. Alternatively, an immobilized antibody specific for the species to be anchored can be used to anchor the species to the solid surface. The surfaces can be prepared in advance and stored.

In order to conduct the assay, the partner of the immobilized species is exposed to the coated surface with or without the test compound. After the reaction is complete, unreacted components are removed (e.g., by washing) and any complexes formed will remain immobilized on the solid surface. The detection of complexes anchored on the solid surface can be accomplished in a number of ways. Where the non-immobilized species is pre-labeled, the detection of label immobilized on the surface indicates that complexes were formed. Where the non-immobilized species is not pre-labeled, an indirect label can be used to detect complexes anchored on the surface; e.g., using a labeled antibody specific for the initially non-immobilized species (the antibody, in turn, can be directly labeled or indirectly labeled with a labeled anti-Ig antibody). Depending upon the order of addition of reaction components, test compounds which inhibit complex formation or which disrupt preformed complexes can be detected.

Alternatively, the reaction can be conducted in a liquid phase in the presence or absence of the test compound, the reaction products separated from unreacted components, and complexes detected; e.g., using an immobilized antibody specific for one of the binding components to anchor any complexes formed in solution, and a labeled antibody specific for the other partner to detect anchored complexes. Again, depending upon the order of addition of reactants to the liquid phase, test compounds which inhibit complex or which disrupt preformed complexes can be identified.

In an alternate embodiment of the invention, a homogeneous assay can be used. In this approach, a preformed complex of the target gene product and the interactive cellular or extracellular binding partner product is prepared in which either the target gene products or their binding partners are labeled, but the signal generated by the label is quenched due to complex formation (see, e.g., U.S. Pat. No. 4,109,496 which utilizes this approach for immunoassays). The addition of a test substance that competes with and displaces one of the species from the preformed complex will result in the generation of a signal above background. In this way, test substances which disrupt target gene product-cellular or extracellular binding partner interaction can be identified.

In a particular embodiment, the target gene product can be prepared for immobilization using recombinant DNA techniques. For example, the target gene coding region can be fused to a glutathione-S-transferase (GST) gene using a fusion vector such as pGEX-5X-1, in such a manner that its binding activity is maintained in the resulting fusion product. The interactive cellular or extracellular product can be purified and used to raise a monoclonal antibody, using methods routinely practiced in the art. This antibody can be labeled with the radioactive isotope 125 I, for example, by methods routinely practiced in the art. In a heterogeneous assay, e.g., the GST-Target gene fusion product can be anchored to glutathione-agarose beads. The interactive cellular or extracellular binding partner product can then be added in the presence or absence of the test compound in a manner that allows interaction and binding to occur. At the end of the reaction period, unbound material can be washed away, and the labeled monoclonal antibody can be added to the system and allowed to bind to the complexed components. The interaction between the target gene product and the interactive cellular or extracellular binding partner can be detected by measuring the amount of radioactivity that remains associated with the glutathione-agarose beads. A successful inhibition of the interaction by the test compound will result in a decrease in measured radioactivity.

Alternatively, the GST-target gene fusion product and the interactive cellular or extracellular binding partner product can be mixed together in liquid in the absence of the solid glutathione-agarose beads. The test compound can be added either during or after the binding partners are allowed to interact. This mixture can then be added to the glutathione-agarose beads and unbound material is washed away. Again the extent of inhibition of the binding partner interaction can be detected by adding the labeled antibody and measuring the radioactivity associated with the beads.

These same techniques can be employed using peptide fragments that correspond to the binding domains of the target gene product and the interactive cellular or extracellular binding partner (in case where the binding partner is a product), in place of one or both of the full length products. Any number of methods routinely practiced in the art can be used to identify and isolate the protein's binding site. These methods include, but are not limited to, mutagenesis of one of the genes encoding one of the products and screening for disruption of binding in a co-immunoprecipitation assay. Compensating mutations in the gene encoding the second species in the complex can be selected. Sequence analysis of the genes encoding the respective products will reveal the mutations that correspond to the region of the product involved in interactive binding. Alternatively, one product can be anchored to a solid surface using methods described above, and allowed to interact with and bind to its labeled binding partner, which has been treated with a proteolytic enzyme, such as trypsin. After washing, a short, labeled peptide comprising the binding domain can remain associated with the solid material, which can be isolated and identified by amino acid sequencing. Also, once the gene coding for the cellular or extracellular binding partner product is obtained, short gene segments can be engineered to express peptide fragments of the product, which can then be tested for binding activity and purified or synthesized.

VI. Treatment of Prostate Cancer by Modulation of Differentially Expressed Genes or Gene Products

Prostate cancer can be treated by modulating the expression of a target gene or the activity of a target gene product. The modulation can be of a positive or negative nature, depending on the specific situation involved, but each modulatory event yields a net result in which prostate cancer symptoms are ameliorated.

“Negative modulation,” refers to a reduction in the level and/or activity of target gene product relative to the level and/or activity of the target gene product in the absence of the modulatory treatment.

“Positive modulation,” refers to an increase in the level and/or activity of target gene product relative to the level and/or activity of target gene product in the absence of modulatory treatment.

It is possible that prostate cancer can be caused, at least in part, by an abnormal level of gene product, or by the presence of a gene product exhibiting abnormal activity. As such, the reduction in the level and/or activity of such gene products would bring about the amelioration of prostate cancer symptoms.

Alternatively, it is possible that prostate cancer can be brought about, at least in part, by the absence or reduction of the level of gene expression, or a reduction in the level of a gene product's activity. As such, an increase in the level of gene expression and/or the activity of such gene products would bring about the amelioration of prostate cancer symptoms.

a) Negative Modulatory Techniques

As discussed, above, successful treatment of prostate cancer can be brought about by techniques which serve to inhibit the expression or activity of target gene products.

For example, compounds, e.g., a compound identified using an assays described above, which proves to exhibit negative modulatory activity, can be used in accordance with the invention to prevent and/or ameliorate symptoms of prostate cancer. Such molecules can include, but are not limited to peptides, phosphopeptides, small organic or inorganic molecules, or antibodies (including, for example, polyclonal, monoclonal, humanized, anti-idiotypic, chimeric or single chain antibodies, and FAb, F(ab′) 2 and FAb expression library fragments, and epitope-binding fragments thereof).

Further, antisense and ribozyme molecules which inhibit expression of the target gene can also be used in accordance with the invention to reduce the level of target gene expression, thus effectively reducing the level of target gene activity. Still further, triple helix molecules can be utilized in reducing the level of target gene activity.

Among the compounds which can exhibit the ability to prevent and/or ameliorate symptoms of prostate cancer are antisense, ribozyme, and triple helix molecules. Such molecules can be designed to reduce or inhibit either wild type, or if appropriate, mutant target gene activity. Techniques for the production and use of such molecules are well known to those of skill in the art.

Anti-sense RNA and DNA molecules act to directly block the translation of mRNA by hybridizing to targeted mRNA and preventing protein translation. With respect to antisense DNA, oligodeoxyribonucleotides derived from the translation initiation site, e.g., between the −10 and +10 regions of the Target gene nucleotide sequence of interest, are preferred.

Ribozymes are enzymatic RNA molecules capable of catalyzing the specific cleavage of RNA. (For a review, see, for example, Rossi, 1994, Current Biology 4:469-471.) The mechanism of ribozyme action involves sequence specific hybridization of the ribozyme molecule to complementary target RNA, followed by a endonucleolytic cleavage. The composition of ribozyme molecules must include one or more sequences complementary to the target gene mRNA and must include the well-known catalytic sequence responsible for mRNA cleavage. For this sequence, see U.S. Pat. No. 5,093,246, which is incorporated by reference herein in its entirety. As such within the scope of the invention are engineered hammerhead motif ribozyme molecules that specifically and efficiently catalyze endonucleolytic cleavage of RNA sequences encoding target gene proteins.

Specific ribozyme cleavage sites within any potential RNA target are initially identified by scanning the molecule of interest for ribozyme cleavage sites which include the following sequences, GUA, GUU, and GUC. Once identified, short RNA sequences of between 15 and 20 ribonucleotides corresponding to the region of the target gene containing the cleavage site can be evaluated for predicted structural features, such as secondary structure, that can render the oligonucleotide sequence unsuitable. The suitability of candidate sequences can also be evaluated by testing their accessibility to hybridization with complementary oligonucleotides, using ribonuclease protection assays.

Nucleic acid molecules to be used in triplex helix formation for the inhibition of transcription should be single stranded and composed of deoxynucleotides. The base composition of these oligonucleotides must be designed to promote triple helix formation via Hoogsteen base pairing rules, which generally require sizeable stretches of either purines or pyrimidines to be present on one strand of a duplex. Nucleotide sequences can be pyrimidine-based, which will result in TAT and CGC + triplets across the three associated strands of the resulting triple helix. The pyrimidine-rich molecules provide base complementarily to a purine-rich region of a single strand of the duplex in a parallel orientation to that strand. In addition, nucleic acid molecules can be chosen that are purine-rich, for example, contain a stretch of G residues. These molecules will form a triple helix with a DNA duplex that is rich in GC pairs, in which the majority of the purine residues are located on a single strand of the targeted duplex, resulting in GGC triplets across the three strands in the triplex.

Alternatively, the potential sequences that can be targeted for triple helix formation can be increased by creating a so called “switchback” nucleic acid molecule. Switchback molecules are synthesized in an alternating 5′-3′, 3′-5′ manner, such that they base pair with first one strand of a duplex and then the other, eliminating the necessity for a sizeable stretch of either purines or pyrimidines to be present on one strand of a duplex.

In instances wherein the antisense, ribozyme, and/or triple helix molecules described herein are utilized to reduce or inhibit mutant gene expression, it is possible that the technique utilized can also efficiently reduce or inhibit the transcription (triple helix) and/or translation (antisense, ribozyme) of mRNA produced by normal target gene alleles such that the possibility can arise wherein the concentration of normal target gene product present can be lower than is necessary for a normal phenotype. In such cases, to ensure that substantially normal levels of target gene activity are maintained, nucleic acid molecules that encode and express target gene polypeptides exhibiting normal target gene activity can be introduced into cells via gene therapy method. Alternatively, in instances in which the target gene encodes an extracellular protein, it can be preferable to co-administer normal target gene protein into the cell or tissue in order to maintain the requisite level of cellular or tissue target gene activity.

Anti-sense RNA and DNA, ribozyme and triple helix molecules of the invention can be prepared by any method known in the art for the synthesis of DNA and RNA molecules. These include techniques for chemically synthesizing oligodeoxyribonucleotides and oligoribonucleotides well known in the art such as, for example, solid phase phosphoramidite chemical synthesis. Alternatively, RNA molecules can be generated by in vitro and in vivo transcription of DNA sequences encoding the antisense RNA molecule. Such DNA sequences can be incorporated into a wide variety of vectors which incorporate suitable RNA polymerase promoters such as the T7 or SP6 polymerase promoters. Alternatively, antisense cDNA constructs that synthesize antisense RNA constitutively or inducibly, depending on the promoter used, can be introduced stably into cell lines.

Various well-known modifications to the DNA molecules can be introduced as a means of increasing intracellular stability and half-life. Possible modifications include but are not limited to the addition of flanking sequences of ribo- or deoxy-nucleotides to the 5′ and/or 3′ ends of the molecule or the use of phosphorothioate or 2′ O-methyl rather than phosphodiesterase linkages within the oligodeoxyribonucleotide backbone.

Antibodies can be generated which are both specific for target gene product and which reduce target gene product activity. Such antibodies may, therefore, by administered in instances whereby negative modulatory techniques are appropriate for the treatment of prostate cancer. Antibodies can be generated using standard techniques against the proteins themselves or against peptides corresponding to portions of the proteins. The antibodies include but are not limited to polyclonal, monoclonal, Fab fragments, single chain antibodies, chimeric antibodies, and the like.

In instances where the target gene protein to which the antibody is directed is intracellular and whole antibodies are used, internalizing antibodies can be preferred. However, lipofectin or liposomes can be used to deliver the antibody or a fragment of the Fab region which binds to the target gene epitope into cells. Where fragments of the antibody are used, the smallest inhibitory fragment which binds to the target protein's binding domain is preferred. For example, peptides having an amino acid sequence corresponding to the domain of the variable region of the antibody that binds to the target gene protein can be used. Such peptides can be synthesized chemically or produced via recombinant DNA technology using methods well known in the art (e.g., see Creighton, 1983, supra; and Sambrook et al., 1989, supra). Alternatively, single chain neutralizing antibodies which bind to intracellular target gene product epitopes can also be administered. Such single chain antibodies can be administered, for example, by expressing nucleotide sequences encoding single-chain antibodies within the target cell population by utilizing, for example, techniques such as those described in Marasco et al. (1993, Proc. Natl. Acad. Sci. USA 90:7889-7893).

b) Positive Modulatory Techniques

As discussed above, successful treatment of prostate cancer symptoms can be brought about by techniques which serve to increase the level of target gene expression or to increase the activity of a target gene product.

For example, compounds, e.g., compounds identified through assays described, which prove to exhibit positive modulatory activity can be used in accordance with the invention to ameliorate prostate cancer symptoms. Such molecules can include, but are not limited to, peptides, phosphopeptides, small organic or inorganic molecules, or antibodies (including, for example, polyclonal, monoclonal, humanized, anti-idiotypic, chimeric or single chain antibodies, and FAb, F(ab′) 2 and FAb expression library fragments, and epitope-binding fragments thereof).

For example, a target gene protein, at a level sufficient to ameliorate prostate cancer symptoms can be administered to a patient exhibiting such symptoms. One of skill in the art will readily know how to determine the concentration of effective, non-toxic doses of the normal target gene protein.

In instances wherein the compound to be administered is a peptide compound, DNA sequences encoding the peptide compound can, alternatively, be directly administered to a patient exhibiting prostate cancer symptoms, at a concentration sufficient to generate the production of an amount of target gene product adequate to ameliorate prostate cancer symptoms. The DNA molecules can be produced, for example, by well-known recombinant techniques.

In the case of peptide compounds which act extracellularly, the DNA molecules encoding such peptides can be taken up and expressed by any cell type, so long as a sufficient circulating concentration of peptide results for the elicitation of a reduction in prostate cancer symptoms.

In the case of compounds which act intracellularly, the DNA molecules encoding such peptides must be taken up and expressed by cells involved in the prostate cancer at a sufficient level to bring about the reduction of prostate cancer symptoms.

Any technique which serves to selectively administer DNA molecules to a cell involved in prostate cancer is, therefore, preferred for the DNA molecules encoding intracellularly acting peptides.

Further, patients can be treated for symptoms of prostate cancer by gene replacement therapy. One or more copies of a normal target gene or a portion of the gene that directs the production of a normal target gene protein with target gene function can be inserted into cells, using vectors which include, but are not limited, to adenovirus, adeno-associated virus, and retrovirus vectors, in addition to other particles that introduce DNA into cells, such as liposomes. Techniques such as those described above can be utilized for the introduction of normal target gene sequences into human cells.

In instances wherein the target gene encodes an extracellular, secreted gene product, such gene replacement techniques may be accomplished either in vivo or in vitro. For such cases, the cell types expressing the target gene is less important than achieving a sufficient circulating concentration of the extracellular molecules for the amelioration of prostate cancer symptoms to occur. In vitro, target gene sequences can be introduced into autologous cells. Those cells expressing the target gene sequence of interest can then be reintroduced, preferably by intravenous administration, into the patient such that there results an amelioration of prostate cancer symptoms.

In instances wherein the gene replacement involves a gene which encodes a product which acts intracellularly, it is preferred that gene replacement be accomplished in vivo. Further, because the cell type in which the gene replacement must occur is the cell type involved in prostate cancer, such techniques must successfully target such prostate cancer cells.

VII. Therapeutic Treatment

The identified compounds that inhibit target gene expression, synthesis and/or activity can be administered to a patient at therapeutically effective doses to prevent, treat or ameliorate prostate cancer. A therapeutically effective dose refers to that amount of the compound sufficient to result in amelioration of symptoms of prostate cancer.

a) Effective Dose

Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD 50 (the dose lethal to 50% of the population) and the ED 50 (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD 50 /ED 50 . Compounds which exhibit large therapeutic indices are preferred. While compounds that exhibit toxic side effects can be used, care should be taken to design a delivery system that targets such compounds to the site of affected-tissue in order to minimize potential damage to uninfected cells and, thereby, reduce side effects.

The data obtained from the cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of such compounds lies preferably within a range of circulating concentrations that include the ED 50 with little or no toxicity. The dosage can vary within this range depending upon the dosage form employed and the route of administration utilized. For any compound used in the method of the invention, the therapeutically effective dose can be estimated initially from cell culture assays. A dose can be formulated in animal models to achieve a circulating plasma concentration range that includes the IC 50 (i.e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma can be measured, for example, by high performance liquid chromatography.

b) Formulations and Use

Pharmaceutical compositions for use in accordance with the present invention can be formulated in conventional manner using one or more physiologically acceptable carriers or excipients.

Thus, the compounds and their physiologically acceptable salts and solvates can be formulated for administration by inhalation or insufflation (either through the mouth or the nose) or oral, buccal, parenteral or rectal administration.

For oral administration, the pharmaceutical compositions can take the form of, for example, tablets or capsules prepared by conventional means with pharmaceutically acceptable excipients such as binding agents (e.g., pregelatinised maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose); fillers (e.g., lactose, microcrystalline cellulose or calcium hydrogen phosphate); lubricants (e.g., magnesium stearate, talc or silica); disintegrants (e.g., potato starch or sodium starch glycolate); or wetting agents (e.g., sodium lauryl sulphate). The tablets can be coated by methods well known in the art. Liquid preparations for oral administration can take the form of, for example, solutions, syrups or suspensions, or they can be presented as a dry product for constitution with water or other suitable vehicle before use. Such liquid preparations can be prepared by conventional means with pharmaceutically acceptable additives such as suspending agents (e.g., sorbitol syrup, cellulose derivatives or hydrogenated edible fats); emulsifying agents (e.g., lecithin or acacia); non-aqueous vehicles (e.g., almond oil, oily esters, ethyl alcohol or fractionated vegetable oils); and preservatives (e.g., methyl or propyl-p-hydroxybenzoates or sorbic acid). The preparations can also contain buffer salts, flavoring, coloring and sweetening agents as appropriate.

Preparations for oral administration can be suitably formulated to give controlled release of the active compound.

For buccal administration the compositions can take the form of tablets or lozenges formulated in conventional manner.

For administration by inhalation, the compounds for use according to the present invention are conveniently delivered in the form of an aerosol spray presentation from pressurized packs or a nebulizer, with the use of a suitable propellant, e.g., dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas. In the case of a pressurized aerosol the dosage unit can be determined by providing a valve to deliver a metered amount. Capsules and cartridges of e.g., gelatin for use in an inhaler or insufflator can be formulated containing a powder mix of the compound and a suitable powder base such as lactose or starch.

The compounds can be formulated for parenteral administration by injection, e.g., by bolus injection or continuous infusion. Formulations for injection can be presented in unit dosage form, e.g., in ampoules or in multi-dose containers, with an added preservative. The compositions can take such forms as suspensions, solutions or emulsions in oily or aqueous vehicles, and can contain formulatory agents such as suspending, stabilizing and/or dispersing agents. Alternatively, the active ingredient can be in powder form for constitution with a suitable vehicle, e.g., sterile pyrogen-free water, before use.

The compounds can also be formulated in rectal compositions such as suppositories or retention enemas, e.g., containing conventional suppository bases such as cocoa butter or other glycerides.

In addition to the formulations described previously, the compounds can also be formulated as a depot preparation. Such long acting formulations can be administered by implantation (for example, subcutaneously or intramuscularly) or by intramuscular injection. Thus, for example, the compounds can be formulated with suitable polymeric or hydrophobic materials (for example as an emulsion in an acceptable oil) or ion exchange resins, or as sparingly soluble derivatives, for example, as a sparingly soluble salt.

The compositions can, if desired, be presented in a pack or dispenser device which can contain one or more unit dosage forms containing the active ingredient. The pack can for example comprise metal or plastic foil, such as a blister pack. The pack or dispenser device can be accompanied by instructions for administration.

Other Embodiments

The present invention is not to be limited in scope by the specific embodiments described which are intended as single illustrations of individual aspects of the invention and functionally equivalent methods and components are within the scope of the invention, in addition to those shown and described herein will become apparent to those skilled in the art from the foregoing description and accompanying drawings. Such modifications are intended to fall within the scope of the appended claims.

191 1 1931 DNA Homo sapiens 1gaattcctga cacgctcctg ggtcgtaggc acaggagtgg gggccaaagc atggagaatc 60aagagaaggc gagtatcgcg ggccacatgt tcgacgtagt cgtgatcgga ggtggcattt 120caggactatc tgctgccaaa ctcttgactg aatatggcgt tagtgttttg gttttagaag 180ctcgggacag ggttggagga agaacatata ctataaggaa tgagcatgtt gattacgtag 240atgttggtgg agcttatgtg ggaccaaccc aaaacagaat cttacgcttg tctaaggagc 300tgggcataga gacttacaaa gtgaatgtca gtgagcgtct cgttcaatat gtcaagggga 360aaacatatcc atttcggggc gcctttccac cagtatggaa tcccattgca tatttggatt 420acaataatct gtggaggaca atagataaca tggggaagga gattccaact gatgcaccct 480gggaggctca acatgctgac aaatgggaca aaatgaccat gaaagagctc attgacaaaa 540tctgctggac aaagactgct aggcggtttg cttatctttt tgtgaatatc aatgtgacct 600ctgagcctca cgaagtgtct gccctgtggt tcttgtggta tgtgaagcag tgcgggggca 660ccactcggat attctctgtc accaatggtg gccaggaacg gaagtttgta ggtggatctg 720gtcaagtgag cgaacggata atggacctcc tcggagacca agtgaagctg aaccatcctg 780tcactcacgt tgaccagtca agtgacaaca tcatcataga gacgctgaac catgaacatt 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ttgacaagtt taaaggctgt gtcattgggc catgtttaag tgtactggat 1740ttaactacct ttggcttaat tccaatcatt gttaaagtaa aaacaattca aagaatcacc 1800taattaattt cagtaagatc aagctccatc ttatttgtca gtgtagatca actcatgtta 1860attgatagaa taaagccttg tgatcacttt ctgaaattca caaagttaaa cgtgatgtgc 1920tcatcagaaa c 1931 2 5508 DNA Homo sapiens 2gattttaggt gatgggcaag tcagaaagtc agatggatat aactgatatc aacactccaa 60agccaaagaa gaaacagcga tggactcgac tggagatcag cctctcggtc cttgtcctgc 120tcctcaccat catagctgtg agaatgatcg cactctatgc aacctacgat gatggtattt 180gcaagtcatc agactgcata aaatcagctg ctcgactgat ccaaaacatg gatgccacca 240ctgagccttg tagagacttt ttcaaatatg cttgcggagg ctggttgaaa cgtaatgtca 300ttcccgagac cagctcccgt tacggcaact ttgacatttt aagagatgaa ctagaagtcg 360ttttgaaaga tgtccttcaa gaacccaaaa ctgaagatat agtagcagtg cagaaagcaa 420aagcattgta caggtcttgt ataaatgaat ctgctattga tagcagaggt ggagaacctc 480tactcaaact gttaccagac atatatgggt ggccagtagc aacagaaaac tgggagcaaa 540aatatggtgc ttcttggaca gctgaaaaag ctattgcaca actgaattct aaatatggga 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gatgacattg tttcaaatga taacaaactg aataatgagt 1500acctcgagtt gaactacaaa gaagatgaat acttcgagaa cataattcaa aatttgaaat 1560tcagccaaag taaacaactg aagaagctcc gagaaaaggt ggacaaagat gagtggataa 1620gtggagcagc tgtagtcaat gcattttact cttcaggaag aaatcagata gtcttcccag 1680ccggcattct gcagcccccc ttctttagtg cccagcagtc caactcattg aactatgggg 1740gcatcggcat ggtcatagga cacgaaatca cccatggctt cgatgacaat ggcagaaact 1800ttaacaaaga tggagacctc gttgactggt ggactcaaca gtctgcaagt aactttaagg 1860agcaatccca gtgcatggtg tatcagtatg gaaacttttc ctgggacctg gcaggtggac 1920agcaccttaa tggaattaat acactgggag aaaacattgc tgataatgga ggtcttggtc 1980aagcatacag agcctatcag aattatatta aaaagaatgg cgaagaaaaa ttacttcctg 2040gacttgacct aaatcacaaa caactatttt tcttgaactt tgcacaggtg tggtgtggaa 2100cctataggcc agagtatgcg gttaactcca ttaaaacaga tgtgcacagt ccaggcaatt 2160tcaggattat tgggactttg cagaactctg cagagttttc agaagccttt cactgccgca 2220agaattcata catgaatcca gaaaagaagt gccgggtttg gtgatcttca aaagaagcat 2280tgcagccctt ggctagactt gccaacacca cagaaatggg gaattctcta atcgaaagaa 2340aatgggccct aggggtcact gtactgactt gagggtgatt aacagagagg gcaccatcac 2400aatacagata acattaggtt gtcctagaaa gggtgtggag ggaggaaggg ggtctaaggt 2460ctatcaagtc aatcatttct cactgtgtac ataatgctta atttctaaag ataatattac 2520tgtttatttc tgtttctcat atggtctacc agtttgctga tgtccctaga aaacaatgca 2580aaacctttga ggtagaccag gatttctaat caaaagggaa aagaagatgt tgaagaatag 2640agttaggcac cagaagaaga gtaggtgaca ctatagttta aaacacattg cctaactact 2700agtttttact tttatttgca acatttacag tccttcaaaa tccttccaaa gaattcttat 2760acacattggg gccttggagc ttacatagtt ttaaactcat ttttgccata catcagttat 2820tcattctgtg atcatttatt ttaagcactc ttaaagcaaa aaatgaatgt ctaaaattgt 2880tttttgttgt acctgctttg actgatgctg agattcttca ggcttcctgc aattttctaa 2940gcaatttctt gctctatctc tcaaaacttg gtatttttca gagatttata taaatgtaaa 3000aataataatt tttatattta attattaact acatttatga gtaactatta ttataggtaa 3060tcaatgaata ttgaagtttc agcttaaaat aaacagttgt gaaccaagat ctataaagcg 3120atatacagat gaaaatttga gactatttaa acttataaat catattgatg aaaagattta 3180agcacaaact ttagggtaaa aattgcgatt ggacagttgt ctagagatat atatacttgt 3240ggttttcaaa ttggactttc aaaattaaat ctgtccctga gagtgtctct gataaaaggg 3300caaatctgca cctatgtagc tctgcatctc ctgtcttttc aggtttgtca tcagatggaa 3360atattttgat aataaattga aattgtgaac tcattgctcc ctaagactgt gacaactgtc 3420taactttaga agtgcatttc tgaatagaaa tgggaggcct ctgatggacc ttctagaatt 3480ataagtcaca aagagttctg gaaaagaact gtttactgct tgataggaat tcatcttttg 3540aggcttctgt tcctctcttt tcctgttgta ttgactattt tcgttcatta cttgattaag 3600attttacaaa agaggagcac ttccaaaatt cttatttttc ctaacaaaag atgaaagcag 3660ggaatttcta tctaaatgat gagtattagt tccctgtctc ttgaaaaatg cccatttgcc 3720tttaaaaaaa aaagttacag aaatactata acatatgtac ataaattgca taaagcataa 3780gtatacagtt caataaactt aactttaact gaacaatggc cctgtagcca gcacctgtaa 3840gaaacagagc agtaccagcg ctctaaaagc acctccttgt cactttatta ctcccagaac 3900aacaactatc ctgacttcta atatcattca ctagctttgc ctggttttgt cttttatgca 3960gatagaatca atcagtatgt attcttttgt gcctggcttc tttctctcag ccttacattt 4020gtgagattcc tctgtattgt gctgattgtg gatcttttca ttctcattgc agaataatgt 4080tctattgtgg gacttattac aatttgttca tcctattgtt gatgggcact tgagaacttt 4140ccattttggc gctattacaa atagtgcaac tatgaatgta ctgcatgtta ccatcttact 4200tgagccttta atggacttat ttcttcaaat ccttccaaaa attattataa gcattgaaat 4260tatagtttca agccaactgt ggataccctt accctttcct cctttatcac aaccaccgtt 4320acaagtatac ttatatttcc ctaaaataca tttaaaactt acctaagtga catttgtagt 4380tggagtaata ggagcttcca gctctaataa aacagctgtc tctaacttat tttatttcca 4440tcatgtcaga gcaggtgaag agccagaagt gaagagtgac tagtacaaat tataaaaagc 4500cactagactc ttcactgtta gctttttaaa acattaggct cccatcccta tggaggaaca 4560actctccagt gcctggatcc cctctgtcta caaatataag attttctggg cctaaaggat 4620agatcaaagt caaaaatagc aatgcctccc tatccctcac acatccagac atcatgaatt 4680ttacatggta ctcttgttga gttctataga gccttctgat gtctctaaag cactaccgat 4740tctttggagt tgtcacatca gataagacat atctctaatt ccatccataa atccagttct 4800actatggctg agttctggtc aaagaaagaa agtttagaag ctgagacaca aagggttggg 4860agctgatgaa actcacaaat gatggtagga agaagctctc gacaataccc gttggcaagg 4920agtctgcctc catgctgcag tgttcgagtg gattgtaggt gcaagatgga aaggattgta 4980ggtgcaagct gtccagagaa aagagtcctt gttccagccc tattctgcca ctcctgacag 5040ggtgaccttg ggtatttgca atattccttt gggcctctgc ttctctcacc taaaaaaaga 5100gaattagatt atattggtgg ttctcagcaa gagaaggagt atgtgtccaa tgctgccttc 5160ccatgaatct gtctcccagt tatgaatcag tgggcaggat aaactgaaaa ctcccattta 5220agtgtctgaa tcgagtgaga caaaatttta gtccaaataa caagtaccaa agttttatca 5280agtttgggtc tgtgctgctg ttactgttaa ccatttaagt ggggcaaaac cttgctaatt 5340ttctcaaaag catttatcat tcttgttgcc acagctggag ctctcaaact aaaagacatt 5400tgttattttg gaaagaagaa agactctatt ctcaaagttt cctaatcaga aatttttatc 5460agtttccagt ctcaaaaata caaaataaaa acaaacgttt ttaatact 5508 3 1050 DNA Homo sapiens 3gggggggggg ggcacttggc ttcaaagctg gctcttggaa attgagcgga gacgagcggc 60ttgttgtagc tgccgtgcgg ccgccgcgga ataataagcc gggatctacc ataccattga 120ctaactatgg aagattatac caaaatagag aaaattggag aaggtaccta tggagttgtg 180tataagggta gacacaaaac tacaggtcaa gtggtagcca tgaaaaaaat cagactagaa 240agtgaagagg aaggggttcc tagtactgca attcgggaaa tttctctatt aaaggaactt 300cgtcatccaa atatagtcag tcttcaggat gtgcttatgc aggattccag gttatatctc 360atctttgagt ttctttccat ggatctgaag aaatacttgg attctatccc tcctggtcag 420tacatggatt cttcacttgt taagagttat ttataccaaa tcctacaggg gattgtgttt 480tgtcactcta gaagagttct tcacagagac ttaaaacctc aaaatctctt gattgatgac 540aaaggaacaa ttaaactggc tgattttggc cttgccagag cttttggaat acctatcaga 600gtatatacac atgaggtagt aacactctgg tacagatctc cagaagtatt gctggggtca 660gctcgttact caactccagt tgacatttgg agtataggca ccatatttgc tgaactagca 720actaagaaac cacttttcca tggggattca gaaattgatc aactcttcag gattttcaga 780gctttgggca ctcccaataa tgaagtgtgg ccagaagtgg aatctttaca ggactataag 840aatacatttc ccaaatggaa accaggaagc ctagcatccc atgtcaaaaa cttggatgaa 900aatggcttgg atttgctctc gaaaatgtta atctatgatc cagccaaacg aatttctggc 960aaaatggcac tgaatcatcc atattttaat gatttggaca atcagattaa gaagatgtag 1020ctttctgaca aaaagtttcc atatgttatg 1050 4 1249 DNA Homo sapiens 4gaattccgta aagctagacc gatctccggg gagccccgag taggcgagcg gcggccgagc 60tagttgagcg caccccccgg gcgccccagc gcgccgcggc gggcgcgtcc aggcggcatg 120gagaaggacg gcctgtgccg cgctgaccag cagtacgaat gcgtggcgga gatcggggag 180ggcgcctatg ggaaggtgtt caaggcccgc gacttgaaga acggaggccg tttcgtggcg 240ttgaagcgcg tgcgggtgca gaccggcgag gagggcatgc cgctctccac catccgcgag 300gtggcggtgc tgaggcacct ggagaccttc gagcacccca acgtggtcag gttgtttgat 360gtgtgcacag tgtcacgaac agacagagaa accaaactaa ctttagtgtt tgaacatgtc 420gatcaagact tgaccactta cttggataaa gttccagagc ctggagtgcc cactgaaacc 480ataaaggata tgatgtttca gcttctccga ggtctggact ttcttcattc acaccgagta 540gtgcatcgcg atctaaaacc acagaacatt ctggtgacca gcagcggaca aataaaactc 600gctgacttcg gccttgcccg catctatagt ttccagatgg ctctaacctc agtggtcgtc 660acgctgtggt acagagcacc cgaagtcttg ctccagtcca gctacgccac ccccgtggat 720ctctggagtg ttggctgcat atttgcagaa atgtttcgta gaaagcctct ttttcgtgga 780agttcagatg ttgatcaact aggaaaaatc ttggacgtga ttggactccc aggagaagaa 840gactggccta gagatgttgc ccttcccagg caggcttttc attcaaaatc tgcccaacca 900attgagaagt ttgtaacaga tatcgatgaa ctaggcaaag acctacttct gaagtgtttg 960acatttaacc cagccaaaag aatatctgcc tacagtgccc tgtctcaccc atacttccag 1020gacctggaaa ggtgcaaaga aaacctggat tcccacctgc cgcccagcca gaacacctcg 1080gagctgaata cagcctgagg cctcagcagc cgccttaagc tgatcctgcg gagaacaccc 1140ttggtggctt atgggtcccc ctcagcaagc cctacagagc tgtggaggat tgctatctgg 1200aggccttcca gctgctgtct tctggacagg ctctgcttct ccaaggaaa 1249 5 4775 DNA Homo sapiens 5acccgcgcga ggtaggcgct ctggtgcttg cggaggacgc ttccttcctc agatgcaccg 60atcttcccga tactgccttt ggagcggcta gattgctagc cttggctgct ccattggcct 120gccttgcccc ttacctgccg attgcatatg aactcttctt ctgtctgtac atcgttgtcg 180tcggagtcgt cgcgatcgtc gtggcgctcg tgtgatggcc ttcgtccgtt tagagtagtg 240tagttagtta ggggccaacg aagaagaaag aagacgcgat tagtgcagag atgctggagg 300tggtcagtta ctaagctaga gtaagatagc ggagcgaaaa gagccaaacc tagccggggg 360gcgcacggtc acccaaagga ggtcgactcg ccggcgcttc ctatcgcgcc gagctccctc 420cattcctctc cctccgccga ggcgcgaggt tgcggcgcgc agcgcagcgc agctcagcgc 480accgactgcc gcgggctccg ctgggcgatt gcagccgagt ccgtttctcg tctagctgcc 540gccgcggcga ccgctgcctg gtcttcctcc cggacgctag tgggttatca gctaacaccc 600gcgagcatct ataacatagg ccaactgacg ccatccttca aaaacaacta aaggatgata 660tgatgaacct agcctgttaa tttcgtcttc tcaattttaa actttggttg cttaagactg 720aagcaatcat ggtgaacctg aggaatgcgg tgcattcatt ccttgtgcac ctaattggcc 780tattggtttg gcaatgtgat atttctgtga gcccagtagc agctatagta actgacattt 840tcaatacctc cgatggtgga cgcttcaaat tcccagacgg ggtacaaaac tggccagcac 900tttcaatcgt catcataata atcatgacaa taggtggcaa catccttgtg atcatggcag 960taagcatgga aaagaaactg cacaatgcca ccaattactt cttaatgtcc ctagccattg 1020ctgatatgct agtgggacta cttgtcatgc ccctgtctct cctggcaatc ctttatgatt 1080atgtctggcc actacctaga tatttgtgcc ccgtctggat ttctttagat gttttatttt 1140caacagcgtc catcatgcac ctctgcgcta tatcgctgga tcggtatgta gcaatacgta 1200atcctattga gcatagccgt ttcaattcgc ggactaaggc catcatgaag attgctattg 1260tttgggcaat ttctataggt gtatcagttc ctatccctgt gattggactg agggacgaag 1320aaaaggtgtt cgtgaacaac acgacgtgcg tgctcaacga cccaaatttc gttcttattg 1380ggtccttcgt agctttcttc ataccgctga cgattatggt gattacgtat tgcctgacca 1440tctacgttct gcgccgacaa gctttgatgt tactgcacgg ccacaccgag gaaccgcctg 1500gactaagtct ggatttcctg aagtgctgca agaggaatac ggccgaggaa gagaactctg 1560caaaccctaa ccaagaccag aacgcacgcc gaagaaagaa gaaggagaga cgtcctaggg 1620gcaccatgca ggctatcaac aatgaaagaa aagcttcgaa agtccttggg attgttttct 1680ttgtgtttct gatcatgtgg tgcccatttt tcattaccaa tattctgtct gttctttgtg 1740agaagtcctg taaccaaaag ctcatggaaa agcttctgaa tgtgtttgtt tggattggct 1800atgtttgttc aggaatcaat cctctggtgt atactctgtt caacaaaatt taccgaaggg 1860cattctccaa ctatttgcgt tgcaattata aggtagagaa aaagcctcct gtcaggcaga 1920ttccaagagt tgccgccact gctttgtctg ggagggagct taatgttaac atttatcggc 1980ataccaatga accggtgatc gagaaagcca gtgacaatga gcccggtata gagatgcaag 2040ttgagaattt agagttacca gtaaatccct ccagtgtggt tagcgaaagg attagcagtg 2100tgtgagaaag aacagcacag tcttttccta cggtacaagc tacatatgta ggaaaatttt 2160cttctttaat ttttctgttg gtcttaacta atgtaaatat tgctgtctga aaaagtgttt 2220ttacatatag ctttgcaacc ttgtacttta caatcatgcc tacattagtg agatttaggg 2280ttctatattt actgtttata ataggtggag actaacttat tttgattgtt tgatgaataa 2340aatgtttatt tttgctctcc ctcccttctt tccttccttt tttcctttct tccttccttt 2400ctctctttct tttgtgcata tggcaacgtt catgttcatc tcaggtggca tttgcaggtg 2460accagaatga ggcacatgac agtggttata tttcaaccac acctaaatta acaaattcag 2520tggacatttg ttctgggtta acagtaaata tacactttac attcttgctc tgctcatcta 2580cacatataaa cacagtaaga taggttctgc tttctgatac atctgtcagt gagtcagagg 2640cagaacctag tcttgttgtt catatagggg caaaaatttg acattgtcag aatgttgtgt 2700tggtatttac tgcaatgtct gtccctaaac atagtggtat tttaacatag cagctggtta 2760accgggacta cagaagtgga aggataatga gatgtaatac accaaatagc ttttcacttc 2820ttaaggacag tgttcaaatt ctgattatta caacaagcaa actgaaatta gtgttttcat 2880tctggtcctt agtaaattcc taattctatg attaaactgg gaaatgagat cccagagtta 2940tttcccaacc caggattcaa catcaattgg gttttgatct cagcatcctg gaaatttgtg 3000tgcttcacac aaagtgaaat tagtattttg agccttatta aaatattttc ttaattatgg 3060tacctctgtc tataggactt aatttagcag tccatttttg agtaaaactt gtattggaag 3120tatagatggt agaaactttg gaagttttac ttgattaagg actacagaat tgggccctta 3180gaatgtgaaa aaaaaaagta attaaaaaga cacttttacc gaactcggga ttacagaaac 3240acggagtttc catttggatt ttaaacaaaa tttatgtcat tttcagatcc ttccaaactc 3300tctagtgcag gaaaaggctg cagctaattt gtgaaagtgg caagctcttc attgcactgc 3360agttatttac cagaagttta aatctttgtt aaaatatagt gttgtgttac aataagtgtt 3420ggccatcatt tcattcgtgg gcctgctgct ctctaagaat tcagtagcat tttaatagtt 3480tctaaaccat gaaaagtttt caagcattgc taaagtcagg ccattcagtc tatgctgtgt 3540gcagagtata caagtgtttc tagtaacagt atttccatac gtgcccattt cacacaactg 3600tggataaatt ttggaagaat tcatgatgct agttcttacg cttgacagtt acttacacac 3660ctgagaatgt gcctctcagt atcttaaaat tggttaatga aaaatctgaa tttctaaaac 3720ccttggtctg tgttctcaac acacagtata gataaatcca atagtctgcc acaagggcag 3780tggaagagct gctgtatttg aggaaactca tacagtctct atttgatttg caacactggc 3840caaacatcag tcatttgctt gagcatgccc aaatattaca tgaaagtcaa gtctacctgc 3900cttgcctgtt aggtctgttg aagtgcatgt taaaataatt atatgaagca gaatgagatg 3960atttaattct taccgaaatg aaaatggctg aagaaacaca gcatgcattt agcatgagtt 4020ctgcacatac agatggtgtc ctgcatgtat gccatgtatg ttgcatgaat ccatcgattt 4080gtattaatgt agggcagaat agctgataga agaaggactg aagaaaatcc ttcagcaatc 4140cttaaaaaga ccatgcattc agatctgaag tagtgtgagt gttagaaaaa actggaaaca 4200tctgatttct gaactatcag ggcaagctca tagcacatgt tttacaaaga aacaaaatat 4260aaatcacaga tttccaaaag tactagcaat aagttgaatg ataatagctc acagcacatt 4320tgttaatgat tcttgtgtca tcaagtagta gtacttaata gtacccaacc tggtaattat 4380cctcaagttg tgtgctattc gtaagttctg tgcagtttgg tatgaaacaa atatactcat 4440ttggatataa atcttaccct tcaatgttaa atctacaaac ttttataaat gttttaaaga 4500agtccatgtg ataattgtaa aggtgatgaa tttaccatca aacaaatcat tttgatgtat 4560tattatatat gtatatctgt gtaagacacg tgcaacagac tgccttatat tattttctgt 4620aattcttctc ctttgtcaaa tggtattttt tgtgaatggt tgcaaagtgt tgtcttattc 4680ctaattcctg tatgttatcc actacaggtt ttatgagact tcctattaat ttattaaatt 4740tattaaatgt tgaaaaaaaa aaaaaaaaaa aaaaa 4775 6 2616 DNA Homo sapiens 6atggcggctc ctcccactgg ggggggggtg gcgcggcggc ggtggcatct gcggccatgg 60cggcgactac tgccaacccc gaaatgacat cagatgtacc atcactgggt ccagccattg 120cctctggaaa ctctggacct ggaattcaag gtggaggagc cattgtccag agggctatta 180agcggcgacc agggctggat tttgatgatg atggagaagg gaacagtaaa tttttgaggt 240gtgatgatga tcagatgtct aacgataagg agcggtttgc caggtcggat gatgagcaga 300gctctgcgga taaagagaga cttgccaggg aaaatcacag tgaaattgaa cggcggcgac 360ggaacaagat gacagcctac atcacagaac tgtcagatat ggtacccacc tgtagtgccc 420tggctcgaaa accagacaag ctaaccatct tacgcatggc agtttctcac atgaagtcct 480tgcggggaac tggcaacaca tccactgatg gctcctataa gccgtctttc ctcactgatc 540aggaactgaa acatttgatc ttggaggcag cagatggctt tctgtttatt gtctcatgtg 600agacaggcag ggtggtgtat gtgtctgact ccgtgactcc tgttttgaac cagccacagt 660ctgaatggtt tggcagcaca ctctatgatc aggtgcaccc agatgatgtg gataaacttc 720gtgagcagct ttccacttca gaaaatgccc tgacagggcg tatcctggat ctaaagactg 780gaacagtgaa aaaggaaggt cagcagtctt ccatgagaat gtgtatgggc tcaaggagat 840cgtttatttg ccgaatgagg tgtggcagta gctctgtgga cccagtttct gtgaataggc 900tgagctttgt gaggaacaga tgcaggaatg gacttggctc tgtaaaggat ggggaacctc 960acttcgtggt ggtccactgc acaggctaca tcaaggcctg gcccccagca ggtgtttccc 1020tcccagatga tgacccagag gctggccagg gaagcaagtt ttgcctagtg gccattggca 1080gattgcaggt aactagttct cccaactgta cagacatgag taatgtttgt caaccaacag 1140agttcatctc ccgacacaac attgagggta tcttcacttt tgtggatcac cgctgtgtgg 1200ctactgttgg ctaccagcca caggaactct taggaaagaa tattgtagaa ttctgtcatc 1260ctgaagacca gcagcttcta agagacagct tccaacaggt agtgaaatta aaaggccaag 1320tgctgtctgt catgttccgg ttccggtcta agaaccaaga atggctctgg atgagaacca 1380gctcctttac tttccagaac ccttactcag atgaaattga gtacatcatc tgtaccaaca 1440ccaatgtgaa gaactctagc caagaaccac ggcctacact ctccaacaca atccagaggc 1500cacaactagg tcccacagct aatttacccc tggagatggg ctcaggacag ctggcaccca 1560ggcagcagca acagcaaaca gaattggaca tggtaccagg aagagatgga ctggccagct 1620acaatcattc ccaggtggtt cagcctgtga caaccacagg accagaacac agcaagcccc 1680ttgagaagtc agatggttta tttgcccagg atagagatcc aagattttca gaaatctatc 1740acaacatcaa tgcggatcag agtaaaggca tctcctccag cactgtccct gccacccaac 1800agctattctc ccagggcaac acattccctc ctaccccccg gccggcagag aatttcagga 1860atagtggcct agcccctcct gtaaccattg tccagccatc agcttctgca ggacagatgt 1920tggcccagat ttcccgccac tccaacccca cccaaggagc aaccccaact tggaccccta 1980ctacccgctc aggcttttct gcccagcagg tggctaccca ggctactgct aagactcgta 2040cttcccagtt tggtgtgggc agctttcaga ctccatcctc cttcagctcc atgtccctcc 2100ctggtgcccc aactgcatcg cctggtgctg ctgcctaccc tagtctcacc aatcgtggat 2160ctaactttgc tcctgagact ggacagactg caggacaatt ccagacacgg acagcagagg 2220gtgtgggtgt ctggccacag tggcagggcc agcagcctca tcatcgttca agttctagtg 2280agcaacatgt tcaacaaccg ccagcacagc aacctggcca gcctgaggtc ttccaggaga 2340tgctgtccat gctgggagat cagagcaaca gctacaacaa tgaagaattc cctgatctaa 2400ctatgtttcc ccccttttca gaatagaact attggggtga ggataagggg tgggggagaa 2460aaaatcactg tttgttttta aaaagcaaat ctttctgtaa acagaataaa agttcctctc 2520ccttcccttc cctcacccct gacatgtacc ccctttccct tctggctgtt cccctgctct 2580gttgcctcct aaggtaacat ttataaaaaa aaaaaa 2616 7 2392 DNA Homo sapiens 7gcgatggaac cagcggagca gccgagcgag ttagtgtcag ccgagggccg aaaccggaag 60gcggtgctgt gccagcgttg cggctcccgg gtgctgcagc cagggaccgc tctcttctct 120cgccgacagc ttttccttcc ctccatgaga aagaagccag ctctgtctga cggcagcaat 180cctgacggcg atctcctcca ggaacactgg ctggttgagg acatgttcat ttttgagaat 240gtgggcttca ccaaggacgt gggcaacatc aagtttctgg tctgcgcaga ctgtgaaatt 300ggaccaattg gctggcattg cctagatgac aagaacagtt tctatgtggc cttggaacga 360gtttcccatg agtaactgag gggaggggta ctcagctcca tctccaaaga taaacctact 420ccccacaaga actggccttt aatgtggtat aactgttccg ctgccttctt gtctgtgcca 480atataaatac tgagtaccag catgtccatt tgaacatgca gagggttaat cctgcttcct 540aaagcctcaa gtacatgcct cctgcttagt tcactttgta tcacatttcc taagctccct 600tttcccccag ttttgggaca ctgtgcttac ctccaaaaat ctcatctctt ccctggcatt 660ctccctaggc tctgttttgc ccaggggctc ccgctttttc ttgctctaga agagcagtat 720tcaacctttt agctatgatg acacataaca aaagatgctt atgtactaat agttgaaatc 780tgcctttttc tcattcaaga aggcatacaa atatctgaga gtgactttgt tgtatggcta 840cccttgtgat ctacagtaat ttattctttc taaaagtaaa gcattttcaa aactcagtat 900ttaaaccact aaccagaaac attactttgg atgcatctct aataccatgt ttgagcacct 960ctgctctagg ttgagaatga cattttattg tgaagatggg tgtggtccct cttcccttga 1020aatcttgtag tttcttttta tattagctcc tcactgctac agcctagaag gtgagaagca 1080gattttaacc ccatctggca gccattcaag gaaaacccag ccctggctgt ttactcaggc 1140tctcttagaa tgagagtgga gggtgtagga tatgagggtt aggcctttgc cacattatac 1200aaaagtttat aatttgccac atctggacaa gtaactttct tcttttgttc ataggcaaga 1260cttctttaat ggatagtatc atttactgaa cctactgggc atggtcctca tggagttttg 1320gttcaactgg aatctctgtg ccaacccagg atacaaactt ccatccagat gcatggatac 1380aaatttccat agctccgggg ctgctctaac agtttgatat cagcagacgt gtttaagcct 1440tcaacttgat ttccaattat tccatcattt ctattctgaa atgactcact gtcgtagaag 1500gaagtttatt atataaccaa ggtttcaggt atcctcctgt caccacctct actattcagg 1560aggcctaaaa ttgaaataag tactaaacag aaaccttacc atctgaagtc ccttccattg 1620ttttctagtt gcttcctcat tcctttaccc ccaaactttc taagggctcc ccgactgcag 1680tgcaaggtgg ccttgggcac agttttgcaa ccaacctact cccctggaaa gatggcttcc 1740ttctccaatt agcctgaatg agctttagta agcaattgag agaactgtgt ttttccgaca 1800aacggtcaca tgtccatcgt tatggcatgt gcagaaaaac agagttatcc acacaagtca 1860ggagcaaaac ccaagtagat gcctctaggg gcacatggcc cctcacatca caagccagaa 1920cctaagctaa gcatttttta aattgagttt gagactagcc tgggcaacat agtgagaccc 1980catctctatt taaaaaatga acaaaattac ctgggcatag tggtgtatac ctgtagtccc 2040tgctacttgg gaggctcagg tgggaggatc acttgagccc caaagatggt ggctgcagta 2100agccaagatc acaccactgg cactccagcc tgggcaacag agtgagaccc tgtctcaaac 2160aaacaacaac agtaacaaca aaaaaatata tagcgacttg aataggaaac catagtattt 2220cattgtttta atttgcattt attttatttc tagtgaaact tttatatacg tatcggtcat 2280ttctatttcc ttttttgaga actgccaaat gttgccctag tagccaaaaa tatcaggttg 2340ctattctgcc ttttcagttt gatctgaaag aaataaaggc atttaagcaa tg 2392 8 2947 DNA Homo sapiens 8ggcgggaaac agcttagtgg gtgtggggtc gcgcattttc ttcaaccagg aggtgaggag 60gtttcgacat ggcggtgcag ccgaaggaga cgctgcagtt ggagagcgcg gccgaggtcg 120gcttcgtgcg cttctttcag ggcatgccgg agaagccgac caccacagtg cgccttttcg 180accggggcga cttctatacg gcgcacggcg aggacgcgct gctggccgcc cgggaggtgt 240tcaagaccca gggggtgatc aagtacatgg ggccggcagg agcaaagaat ctgcagagtg 300ttgtgcttag taaaatgaat tttgaatctt ttgtaaaaga tcttcttctg gttcgtcagt 360atagagttga agtttataag aatagagctg gaaataaggc atccaaggag aatgattggt 420atttggcata taaggcttct cctggcaatc tctctcagtt tgaagacatt ctctttggta 480acaatgatat gtcagcttcc attggtgttg tgggtgttaa aatgtccgca gttgatggcc 540agagacaggt tggagttggg tatgtggatt ccatacagag gaaactagga ctgtgtgaat 600tccctgataa tgatcagttc tccaatcttg aggctctcct catccagatt ggaccaaagg 660aatgtgtttt acccggagga gagactgctg gagacatggg gaaactgaga cagataattc 720aaagaggagg aattctgatc acagaaagaa aaaaagctga cttttccaca aaagacattt 780atcaggacct caaccggttg ttgaaaggca aaaagggaga gcagatgaat agtgctgtat 840tgccagaaat ggagaatcag gttgcagttt catcactgtc tgcggtaatc aagtttttag 900aactcttatc agatgattcc aactttggac agtttgaact gactactttt gacttcagcc 960agtatatgaa attggatatt gcagcagtca gagcccttaa cctttttcag ggttctgttg 1020aagataccac tggctctcag tctctggctg ccttgctgaa taagtgtaaa acccctcaag 1080gacaaagact tgttaaccag tggattaagc agcctctcat ggataagaac agaatagagg 1140agagattgaa tttagtggaa gcttttgtag aagatgcaga attgaggcag actttacaag 1200aagatttact tcgtcgattc ccagatctta accgacttgc caagaagttt caaagacaag 1260cagcaaactt acaagattgt taccgactct atcagggtat aaatcaacta cctaatgtta 1320tacaggctct ggaaaaacat gaaggaaaac accagaaatt attgttggca gtttttgtga 1380ctcctcttac tgatcttcgt tctgacttct ccaagtttca ggaaatgata gaaacaactt 1440tagatatgga tcaggtggaa aaccatgaat tccttgtaaa accttcattt gatcctaatc 1500tcagtgaatt aagagaaata atgaatgact tggaaaagaa gatgcagtca acattaataa 1560gtgcagccag agatcttggc ttggaccctg gcaaacagat taaactggat tccagtgcac 1620agtttggata ttactttcgt gtaacctgta aggaagaaaa agtccttcgt aacaataaaa 1680actttagtac tgtagatatc cagaagaatg gtgttaaatt taccaacagc aaattgactt 1740ctttaaatga agagtatacc aaaaataaaa cagaatatga agaagcccag gatgccattg 1800ttaaagaaat tgtcaatatt tcttcaggct atgtagaacc aatgcagaca ctcaatgatg 1860tgttagctca gctagatgct gttgtcagct ttgctcacgt gtcaaatgga gcacctgttc 1920catatgtacg accagccatt ttggagaaag gacaaggaag aattatatta aaagcatcca 1980ggcatgcttg tgttgaagtt caagatgaaa ttgcatttat tcctaatgac gtatactttg 2040aaaaagataa acagatgttc cacatcatta ctggccccaa tatgggaggt aaatcaacat 2100atattcgaca aactggggtg atagtactca tggcccaaat tgggtgtttt gtgccatgtg 2160agtcagcaga agtgtccatt gtggactgca tcttagcccg agtaggggct ggtgacagtc 2220aattgaaagg agtctccacg ttcatggctg aaatgttgga aactgcttct atcctcaggt 2280ctgcaaccaa agattcatta ataatcatag atgaattggg aagaggaact tctacctacg 2340atggatttgg gttagcatgg gctatatcag aatacattgc aacaaagatt ggtgcttttt 2400gcatgtttgc aacccatttt catgaactta ctgccttggc caatcagata ccaactgtta 2460ataatctaca tgtcacagca ctcaccactg aagagacctt aactatgctt tatcaggtga 2520agaaaggtgt ctgtgatcaa agttttggga ttcatgttgc agagcttgct aatttcccta 2580agcatgtaat agagtgtgct aaacagaaag ccctggaact tgaggagttt cagtatattg 2640gagaatcgca aggatatgat atcatggaac cagcagcaaa gaagtgctat ctggaaagag 2700agcaaggtga aaaaattatt caggagttcc tgtccaaggt gaaacaaatg ccctttactg 2760aaatgtcaga agaaaacatc acaataaagt taaaacagct aaaagctgaa gtaatagcaa 2820agaataatag ctttgtaaat gaaatcattt cacgaataaa agttactacg tgaaaaatcc 2880cagtaatgga atgaaggtaa tattgataag ctattgtctg taatagtttt atattgtttt 2940atattaa 2947 9 3805 DNA Homo sapiens 9ggctcggctc ctagagctgc cacggccatg gccagagccc gcccgccgcc gccgccgtcg 60ccgccgccgg ggcttctgcc gctgctccct ccgctgctgc tgctgccgct gctgctgctg 120cccgccggct gccgggcgct ggaagagacc ctcatggaca caaaatgggt aacatctgag 180ttggcgtgga catctcatcc agaaagtggg tgggaagagg tgagtggcta cgatgaggcc 240atgaatccca tccgcacata ccaggtgtgt aatgtgcgcg agtcaagcca gaacaactgg 300cttcgcacgg ggttcatctg gcggcgggat gtgcagcggg tctacgtgga gctcaagttc 360actgtgcgtg actgcaacag catccccaac atccccggct cctgcaagga gaccttcaac 420ctcttctact acgaggctga cagcgatgtg gcctcagcct cctccccctt ctggatggag 480aacccctacg tgaaagtgga caccattgca cccgatgaga gcttctcgcg gctggatgcc 540ggccgtgtca acaccaaggt gcgcagcttt gggccacttt ccaaggctgg cttctacctg 600gccttccagg accagggcgc ctgcatgtcg ctcatctccg tgcgcgcctt ctacaagaag 660tgtgcatcca ccaccgcagg cttcgcactc ttccccgaga ccctcactgg ggcggagccc 720acctcgctgg tcattgctcc tggcacctgc atccctaacg ccgtggaggt gtcggtgcca 780ctcaagctct actgcaacgg cgatggggag tggatggtgc ctgtgggtgc ctgcacctgt 840gccaccggcc atgagccagc tgccaaggag tcccagtgcc gcccctgtcc ccctgggagc 900tacaaggcga agcagggaga ggggccctgc ctcccatgtc cccccaacag ccgtaccacc 960tccccagccg ccagcatctg cacctgccac aataacttct accgtgcaga ctcggactct 1020gcggacagtg cctgtaccac cgtgccatct ccaccccgag gtgtgatctc caatgtgaat 1080gaaacctcac tgatcctcga gtggagtgag ccccgggacc tgggtgtccg ggatgacctc 1140ctgtacaatg tcatctgcaa gaagtgccat ggggctggag gggcctcagc ctgctcacgc 1200tgtgatgaca acgtggagtt tgtgcctcgg cagctgggcc tgtcggagcc ccgggtccac 1260accagccatc tgctggccca cacgcgctac acctttgagg tgcaggcggt caacggtgtc 1320tcgggcaaga gccctctgcc gcctcgttat gcggccgtga atatcaccac aaaccaggct 1380gccccgtctg aagtgcccac actacgcctg cacagcagct caggcagcag cctcacccta 1440tcctgggcac ccccagagcg gcccaacgga gtcatcctgg actacgagat gaagtacttt 1500gagaagagcg agggcatcgc ctccacagtg accagccaga tgaactccgt gcagctggac 1560gggcttcggc ctgacgcccg ctatgtggtc caggtccgtg cccgcacagt agctggctat 1620gggcagtaca gccgccctgc cgagtttgag accacaagtg agagaggctc tggggcccag 1680cagctccagg agcagcttcc cctcatcgtg ggctccgcta cagctgggct tgtcttcgtg 1740gtggctgtcg tggtcatcgc tatcgtctgc ctcaggaagc agcgacacgg ctctgattcg 1800gagtacacgg agaagctgca gcagtacatt gctcctggaa tgaaggttta tattgaccct 1860tttacctacg aggaccctaa tgaggctgtt cgggagtttg ccaaggagat cgacgtgtcc 1920tgcgtcaaga tcgaggaggt gatcggagct ggggaatttg gggaagtgtg ccgtggtcga 1980ctgaaacagc ctggccgccg agaggtgttt gtggccatca agacgctgaa ggtgggctac 2040accgagaggc agcggcggga cttcctaagc gaggcctcca tcatgggtca gtttgatcac 2100cccaatataa tccggctcga gggcgtggtc accaaaagtc ggccagttat gatcctcact 2160gagttcatgg aaaactgcgc cctggactcc ttcctccggc tcaacgatgg gcagttcacg 2220gtcatccagc tggtgggcat gttgcggggc attgctgccg gcatgaagta cctgtccgag 2280atgaactatg tgcaccgcga cctggctgct cgcaacatcc ttgtcaacag caacctggtc 2340tgcaaagtct cagactttgg cctctcccgc ttcctggagg atgacccctc cgatcctacc 2400tacaccagtt ccctgggcgg gaagatcccc atccgctgga ctgccccaga ggccatagcc 2460tatcggaagt tcacttctgc tagtgatgtc tggagctacg gaattgtcat gtgggaggtc 2520atgagctatg gagagcgacc ctactgggac atgagcaacc aggatgtcat caatgccgtg 2580gagcaggatt accggctgcc accacccatg gactgtccca cagcactgca ccagctcatg 2640ctggactgct gggtgcggga ccggaacctc aggcccaaat tctcccagat tgtcaatacc 2700ctggacaagc tcatccgcaa tgctgccagc ctcaaggtca ttgccagcgc tcagtctggc 2760atgtcacagc ccctcctgga ccgcacggtc ccagattaca caaccttcac gacagttggt 2820gattggctgg atgccatcaa gatggggcgg tacaaggaga gcttcgtcag tgcggggttt 2880gcatcttttg acctggtggc ccagatgacg gcagaagacc tgctccgtat tggggtcacc 2940ctggccggcc accagaagaa gatcctgagc agtatccagg acatgcggct gcagatgaac 3000cagacgctgc ctgtgcaggt ctgacaccgg ctcccacggg gaccctgagg accgtgcagg 3060gatgccaagc agccggctgg actttcggac tcttggactt ttggatgcct ggccttaggc 3120tgtggcccag aagctggaag tttgggaaag gcccaagctg ggacttctcc aggcctgtgt 3180tccctcccca ggaagtgcgc cccaaacctc ttcatattga agatggatta ggagaggggg 3240tgatgacccc tccccaagcc cctcagggcc cagaccttcc tgctctccag caggggatcc 3300ccacaacctc acacttgtct gttcttcagt gctggaggtc ctggcagggt caggctgggg 3360taagccgggg ttccacaggg cccagccctg gcaggggtct ggccccccag gtaggcggag 3420agcagtccct ccctcaggaa ctggaggagg ggactccagg aatggggaaa tgtgacacca 3480ccatcctgaa gccagcttgc acctccagtt tgcacaggga tttgtcctgg gggctgaggg 3540ccctgtcccc acccccgccc ttggtgctgt cataaaaggg caggcagggg caggctgagg 3600agttgcccgt tgccccccag agactgactc tcagagccag agatgggatg tgtgagtgtg 3660tgtgtgtgtg tgtgcgcgcg cgcgcgcgtg tgtgtgtgca cgcactggcc tgcacagaga 3720gcatgggtga gcgtgtaaaa gcttggccct gtgccctaca gtggggacag ctgggccgac 3780agcagaataa aggcaataag atgaa 3805 10 541 DNA Homo sapiens misc_feature (1)...(541) n = A,T,C or G 10tttttttttt ttaggatatt tgnaaataca actttattnc tgnattgcta aacgcaaaag 60gnaatgggna atgacagtaa caaacaagtt ttcaccactg naatattgtg atgtgactgc 120agacagtctt atatatgnaa actcaaggga atcaactgcg ttccaaaaca gctaaatatg 180caggtccaaa caatgaagtt attttttaaa ctgccacatt cactccgaag ncccactcat 240ctccttcagg catcccacag atgaaggcac atgttccgct tagctagata ataatgaggt 300gggcacacac gctgcaccgc tgacatcaca ggacagctgc ctataaaact agacttctga 360cgctgggctc cagcttcatt ctcacaggtc atcatcctca tccgggagag cagttgtctg 420agcaacctct aagtcgtgct catactgtgc tgccaaagct gggtccatga caactttggt 480ggggcgagan agggcatggc aacaaattca agttgggttc aatgagttct gcaagcagag 540g 541 11 1860 DNA Homo sapiens 11cgtgaacggt cgttgcagag attgcgggcg gctgagacgc cgcctgcctg gcacctagga 60gcgcagcgga gccccgacac cgccgccgcc gccatggagt ccgagaccga acccgagccc 120gtcacgctcc tggtgaagag ccccaaccag cgccaccgcg acttggagct gagtggcgac 180cgcggctgga gtgtgggcca cctcaaggcc cacctgagcc gcgtctaccc cgagcgtccg 240cgtccagagg accagaggtt aatttattct gggaagctgt tgttggatca ccaatgtctc 300agggacttgc ttccaaagca ggaaaaacgg catgttttgc atctggtgtg caatgtgaag 360agtccttcaa aaatgccaga aatcaacgcc aaggtggctg aatccacaga ggagcctgct 420ggttctaatc ggggacagta tcctgaggat tcctcaagtg atggtttaag gcaaagggaa 480gttcttcgga acctttcttc ccctggatgg gaaaacatct caaggcctga agctgcccag 540caggcattcc aaggcctggg tcctggtttc tccggttaca caccctatgg gtggcttcag 600ctttcctggt tccagcagat atatgcacga cagtactaca tgcaatattt agcagccact 660gctgcatcag gggcttttgt tccaccacca agtgcacaag agatacctgt ggtctctgca 720cctgctccag cccctattca caaccagttt ccagctgaaa accagcctgc caatcagaat 780gctgctcctc aagtggttgt taatcctgga gccaatcaaa atttgcggat gaatgcacaa 840ggtggcccta ttgtggaaga agatgatgaa ataaatcgag attggttgga ttggacctat 900tcagcagcta cattttctgt ttttctcagt atcctctact tctactcctc cctgagcaga 960ttcctcatgg tcatgggggc caccgttgtt atgtacctgc atcacgttgg gtggtttcca 1020tttagaccga ggccggttca gaacttccca aatgatggtc ctcctcctga cgttgtaaat 1080caggacccca acaataactt acaggaaggc actgatcctg aaactgaaga ccccaaccac 1140ctccctccag acagggatgt actagatggc gagcagacca gcccctcctt tatgagcaca 1200gcatggcttg tcttcaagac tttctttgcc tctcttcttc cagaaggccc cccagccatc 1260gcaaactgat ggtgtttgtg ctgtagctgt tggaggcttt gacaggaatg gactggatca 1320cctgactcca gctagattgc ctctcctgga catggcaatg atgagttttt aaaaaacagt 1380gtggatgatg atatgctttt gtgagcaagc aaaagcagaa acgtgaagcc gtgatacaaa 1440ttggtgaaca aaaaatgccc aaggcttctc atgtgtttat tctgaagagc tttaatatat 1500actctatgta gtttaataag cactgtacgt agaaggcctt aggtgttgca tgtctatgct 1560tgaggaactt ttccaaatgt gtgtgtctgc atgtgtgttt gtacatagaa gtcatagatg 1620cagaagtggt tctgctggta agatttgatt cctgttggaa tgtttaaatt acactaagtg 1680tactacttta tataatcaat gaaattgcta gacatgtttt agcaggactt ttctaggaaa 1740gacttatgta taattgcttt ttaaaatgca gtgctttact ttaaactaag gggaactttg 1800cggaggtgaa aacctttgct gggttttctg ttcaataaag ttttactatg aatgaccctg 1860 12 3379 DNA Homo sapiens 12aattccgcgg aatcatcgga atccttcacc atggcatcca gcccggccca gcgtcggcga 60ggcaatgatc ctctcacctc cagccctggc cgaagctccc ggcgtactga tgccctcacc 120tccagccctg gccgtgacct tccaccattt gaggatgagt ccgaggggct cctaggcaca 180gaggggcccc tggaggaaga agaggatgga gaggagctca ttggagatgg catggaaagg 240gactaccgcg ccatcccaga gctggacgcc tatgaggccg agggactggc tctggatgat 300gaggacgtag aggagctgac ggccagtcga agggaggcag cagacgggcc atgcggcacg 360gtgaccggga gctggccggg gctgggcgca tgcgccgtgg gctcctgtat gacagcgatg 420aggaggacga ggagcgccct gcccgcaagc gccgccagtg gagccggcac ggaggacggc 480gaggaggacg agcagatgat tgagagcatc gagaacctgg aggatctcaa aggccactct 540gtgcgcgagt gggtgagcat ggcgggcccc cggctggaga tccaccaccg cttcaagaac 600ttcctgcgca ctcacgtcga cagccacggc cacaacgtct tcaaggagcg catcagcgac 660atgtgcaaag agaaccgtga gagcctggtg gtgaactatg aggacttggc agccagggag 720cacgtgctgg cctacttcct gcctgaggca ccggcggagc tgctgcagat ctttgatgag 780gctgccctgg aggtggtact ggccatgtac cccaagtacg accgcatcac caaccacatc 840catgtccgca tctcccacct gcctctggtg gaggagctgc gctcgctgag gcagctgcat 900ctgaaccagc tgatccgcac cagtggggtg gtgaccagct gcactggcgt cctgccccag 960ctcagcatgg tcaagtacaa ctgcaacaag tgcaatttcg tcctgggtcc tttctgccag 1020tcccagaacc aggaggtgaa accaggctcc tgtcctgagt gccagtcggc cggccccttt 1080gaggtcaaca tggaggagac catctatcag aactaccagc gtatccgaat ccaggagagt 1140ccaggcaaag tggcggctcg gcggctgccc cgctccaagg acgccattct cctcgcagat 1200ctggtggaca gctgcaacgc aggagacgag atagagctga ctggcatcta tcacaacaac 1260tatgatggct ccctcaacac tgccaatggc ttccctgtct ttgccactgt catcctagcc 1320aaccacgtgg ccaagaagga caacaaggtt gctgtagggg aactgaccga tgaagatgtg 1380aagatgatca ctagcctctc caaggatcag cagatcggag agaagatctt tgccagcatt 1440gctccttcca tctatggtca tgaagacatc aagagaggcc ctgctctggc cctgttcgga 1500ggggagccca aaaacccagg tggcaagcac aaggtacgtg gtgatatcaa cgtgctcttg 1560tgcggagacc ctggcacagc gaagtcgcag tttctcaagt atattgagaa agtgtccagc 1620cgagccatct tcaccactgg ccagggggcg tcggctgtgg ccgtcacggc gtatgtccag 1680cggcaccctg tcagcaggga gtggaccttg gaggctgggg ccctggttct ggctgaccga 1740ggagtgtgtc tcattgatga atttgacaag atgaatgacc aggacagaac cagcatccat 1800gaggccatgg agcaacagag catctccatc tcgaaggctg gcatcgtcac ctccctgcag 1860gctcgctgca cggtcattgc tgccgccaac cccataggag ggcgctacga cccctcgctg 1920actttctctg agaacgtgga cctcacagag cccatcatct cacgctttga catcctgtgt 1980gtggtgaggg acaccgtgga cccagtccag gacgagatgc tggcccgctt cgtggtgggc 2040agccacgtca gacaccaccc cagcaacaag gaggaggagg ggctggccaa tggcagcgct 2100gctgagcccg ccatgcccaa cacgtatggc gtggagcccc tgccccagga ggtcctgaag 2160aagtacatca tctacgccaa ggagagggtc cacccgaagc tcaaccagat ggaccaggac 2220aaggtggcca agatgtacag tgacctgagg aaagaatcta tggcgacagg cagcatcccc 2280attacggtgc ggcacatcga gtccatgagt catggcggag gcccacgcgc gcatccatct 2340gcgggactat gtgatcgaag acgacgtcaa catggccatc cgcgtgatgc tggagagctt 2400catagacaca cagaagttca gcgtcatcgc agcatgcgca agacttttgc ccgctacctt 2460tcattccggc gtgacaacaa tgagctgttg ctcttcatac tgaagcagtt agtggcagag 2520caggtgacat atcagcgcaa ccgctttggg gcccagcagg acactattga ggtccctgag 2580aaggacttgg tggataaggc tcgtcagatc aacatccaca acctctctgc attttatgac 2640agtgagctct tcaggatgaa caagttcagc cacgacctga aaaggaaaat gatcctgcag 2700cagttctgag gccctatgcc atccataagg attccttggg attctggttt ggggtggtca 2760gtgccctctg tgctttatgg acacaaaacc agagcacttg atgaactcgg ggtactaggg 2820tcagggctta tagcaggatg tctggctgca cctggcatga ctgtttgttt ctccaagcct 2880gctttgtgct tctcaccttt gggtgggatg ccttgccagt gtgtcttact tggttgctga 2940acatcttgcc acctccgagt gctttgtctc cactcagtac cttggatcag agctgctgag 3000ttcaggatgc ctgcgtgtgg tttaggtgtt agccttctta catggatgtc aggagagctg 3060ctgccctctt ggcgtgagtt gcgtattcag gctgcttttg ctcgctttgg ccagagagct 3120ggttgaagat gtttgtaatc gttttcagtc tcctgcaggt ttctgtgccc ctgtggtgga 3180agaggcacga cagtgccagc gcagcgttct gggctcctca gtcgcagggg tgggatgtga 3240gtcatgcgga ttatccactc gccacagtta tcagctgcca ttgctccctg tctgtttccc 3300cactctctta tttgtgcatt cggtttggtt tctgtagttt taatttttaa taaagttgaa 3360taaaatataa aaaaaaaaa 3379 13 767 DNA Homo sapiens misc_feature (1)...(767) n = A,T,C or G 13agatgaagta gagtgctctg acaaggacga gcccgacctc gatggggatg tgtccagcga 60ctgccccacc atccgcgtcc cactgacatc cctcaagagc caccagggcg tggtcatcgc 120ctccgactgg ctggttgggg ggaagcaggc tgtgactgcc tcctgggacc ggacggcaaa 180cctgtacgac gtggagacgt ccgagctcgt tcactctctg acagggcacg accaggagtt 240gacgcactgc tgcacacacc ccacccagcg gctcgtggtg acctcctccc gtgacacgac 300tttccgcctc tgggatttca gggacccctc catccactct tatggaacat ggacatttta 360atgaatttca tattgcaatg aagacagtca acacttagag acaattatat cgatacaata 420aaaactgatt ccatggaaca cttataaatg catacatttt cctccaaaga aatatgtttt 480tcacagactt aagtaacaaa tgatttacat aggattcttc agattccaaa atatgtacag 540agtttttgtc tctacagaaa ctgatgagca gtggttgaaa aagagttgct ttgcccaaca 600gcatggctct tatgaaattc ctgtatcata tacagttttc agtaaccaca cattttcccg 660tctatcatta aatggaattc tgggacacat ccagcatacc nggaccaaac tggttcccac 720tttnccaaac actggtttca gacgagattc acgtggtngg tttgaac 767 14 500 DNA Homo sapiens 14tgccgctgca gcagcgcagt tccagtccgt tgctttactt tttgcttcac cgacatagtc 60attatgccga agagaaagtc tccagagaat acagagggca aagatggatc caaagtaact 120aaacaggagc ccacaagacg gtctgccaga ttgtcagcga aacctgctcc accaaaacct 180gaacccaaac caagaaaaac atctgctaag aaagaacctg gagcaaagat tagcagaggt 240gctaaaggga agaaggagga aaagcaggaa gctggaaagg aaggtactgc accatctgaa 300aatggtgaaa ctaaagctga agaggcacag aaaactgaat ctgtagataa cgagggagaa 360tgaattgtca tgaaaaattg gggttgattt tatgtatctc ttgggacaac ttttaaaagc 420tatttttacc aagtattttg taaatgctaa ttttttagga ctctactagt tggcatacga 480aaatatataa ggatggacat 500 15 2287 DNA Homo sapiens 15ggctgaggca gtggctcctt gcacagcagc tgcacgcgcc gtggctccgg atcttcttcg 60tctttgcagc gtagcccgag tcggtcagcg ccagaggacc tcagcagcca tgtcgaagcc 120ccatagtgaa gccgggactg ccttcattca gacccagcag ctgcacgcag ccatggctga 180cacattcctg gagcacatgt gccgcctgga cattgattca ccacccatca cagcccggaa 240cactggcatc atctgtacca ttggcccagc ttcccgatca gtggagacgt tgaaggagat 300gattaagtct ggaatgaatg tggctcgtct gaacttctct catggaactc atgagtacca 360tgcggagacc atcaagaatg tgcgcacagc cacggaaagc tttgcttctg accccatcct 420ctaccggccc gttgctgtgg ctctagacac taaaggacct gagatccgaa ctgggctcat 480caagggcagc ggcactgcag aggtggagct gaagaaggga gccactctca aaatcacgct 540ggataacgcc tacatggaaa agtgtgacga gaacatcctg tggctggact acaagaacat 600ctgcaaggtg gtggaagtgg gcagcaagat ctacgtggat gatgggctta tttctctcca 660ggtgaagcag aaaggtgccg acttcctggt gacggaggtg gaaaatggtg gctccttggg 720cagcaagaag ggtgtgaacc ttcctggggc tgctgtggac ttgcctgctg tgtcggagaa 780ggacatccag gatctgaagt ttggggtcga gcaggatgtt gatatggtgt ttgcgtcatt 840catccgcaag gcatctgatg tccatgaagt taggaaggtc ctgggagaga agggaaagaa 900catcaagatt atcagcaaaa tcgagaatca tgagggggtt cggaggtttg atgaaatcct 960ggaggccagt gatgggatca tggtggctcg tggtgatcta ggcattgaga ttcctgcaga 1020gaaggtcttc cttgctcaga agatgatgat tggacggtgc aaccgagctg ggaagcctgt 1080catctgtgct actcagatgc tggagagcat gatcaagaag ccccgcccca ctcgggctga 1140aggcagtgat gtggccaatg cagtcctgga tggagccgac tgcatcatgc tgtctggaga 1200aacagccaaa ggggactatc ctctggaggc tgtgcgcatg cagaacctga ttgcccgtga 1260ggcagaggct gccatctacc acttgcaatt atttgaggaa ctccgccgcc tggcgcccat 1320taccagcgac cccacagaag ccaccgccgt gggtgccgtg gaggcctcct tcaagtgctg 1380cagtggggcc ataatcgtcc tcaccaagtc tggcaggtct gctcaccagg tggccagata 1440ccgcccacgt gcccccatca ttgctgtgac ccggaatccc cagacagctc gtcaggccca 1500cctgtaccgt ggcatcttcc ctgtgctgtg caaggaccca gtccaggagg cctgggctga 1560ggacgtggac ctccgggtga actttgccat gaatgttggc aaggcccgag gcttcttcaa 1620gaagggagat gtggtcattg tgctgaccgg atggcgccct ggctccggct tcaccaacac 1680catgcgtgtt gttcctgtgc cgtgatggac cccagagccc ctcctccagc ccctgtccca 1740cccccttccc ccagcccatc cattaggcca gcaacgcttg tagaactcac tctgggctgt 1800aacgtggcac tggtaggttg ggacaccagg gaagaagatc aacgcctcac tgaaacatgg 1860ctgtgtttgc agcctgctct agtgggacag cccagagcct ggctgcccca tcatgtggcc 1920ccacccaatc aagggaagaa ggaggaatgc tggactggag gcccctggag ccagatggca 1980agagggtgac agcttccttt cctgtgtgta ctctgtccag ttcctttaga aaaaatggat 2040gcccagagga ctcccaaccc tggcttgggg tcaagaaaca gccagcaaga gttaggggcc 2100ttagggcact gggctgttgt tccattgaag ccgactctgg ccctggccct tacttgcttc 2160tctagctctc taggcctctc cagtttgcac ctgtccccac cctccactca gctgtcctgc 2220agcaaacact ccaccctcca ccttccattt tcccccacta ctgcagcacc tccaggcctg 2280ttgccgc 2287 16 3183 DNA Homo sapiens 16cctccaggcc ccgccgcgcg tcccgggggc cggccccgcg agcgcaggag taaacaccgc 60cggagtcttg gagccgctgc agaagggaat aaagagagat gcagggattt gtgaggttac 120ggcgccccag ctgcaagatg cactagccgg ctgaacccgg gatcggctga cttgttggaa 180ccggagtgct ctgcacggag agtggtggat gagttgaagt tgccttcccg gggctcattt 240tccacgctgc cgagaggaat ccgagaggca aggcaatcac ttcgtcttgc cattgattgg 300gtatcgggag cttttttttt ctcccctctc tctttctttt cctccgtctt gttgcatgca 360agaaaattac agtccgctgc tcgcccgccc tgggtgcgag atattcagcc ccgctctctc 420ccgtgcattg tgcaacccaa agatgaaaga ccgaagggga gaaagttaaa gaaatcgccc 480acatgcgctg gatcagtcca cggcttgggg aaaggcatcc agagaaggtg ggagcggaga 540gtttgaagtc tttacaggcg ggaagatggc ggactggagc tgaaagtgtt gattgggaaa 600cttgggtgat tcttgtgttt atttacaatc ctcttgaccc aggcaggaca catgcaggcc 660aaaaaacgct atttcatcct gctctcagct ggctcttgtc tcgccctttt gttttatttc 720ggaggcttgc agtttagggc atcgaggagc cacagccgga gagaagaaca cagcggtagg 780aatggcttgc accaccccag tccggatcat ttctggcccc gcttcccgga gcctctgcgc 840cccttcgttc cttgggatca attggaaaac gaggattcca gcgtgcacat ttccccccgg 900cagaagcgag atgccaactc cagcatctac aaaggcaaga agtgccgcat ggagtcctgc 960ttcgatttca ccctttgcaa gaaaaacggc ttcaaagtct acgtataccc acagcaaaaa 1020ggggagaaaa tcgccgaaag ttaccaaaac attctagcgg ccatcgaggg ctccaggttc 1080tacacctcgg accccagcca ggcgtgcctc tttgtcctga gtctggatac tttagacaga 1140gaccagttgt cacctcagta tgtgcacaat ttgagatcca aagtgcagag tctccacttg 1200tggaacaatg gtaggaatca tttaattttt aatttatatt ccggcacttg gcctgactac 1260accgaggacg tggggtttga catcggccag gcgatgctgg ccaaagccag catcagtact 1320gaaaacttcc gacccaactt tgatgtttct attcccctct tttctaagga tcatcccagg 1380acaggagggg agagggggtt tttgaagttc aacaccatcc ctcctctcag gaagtacatg 1440ctggtattca aggggaagag gtacctgaca gggataggat cagacaccag gaatgcctta 1500tatcacgtcc ataacgggga ggacgttgtg ctcctcacca cctgcaagca tggcaaagac 1560tggcaaaagc acaaggattc tcgctgtgac agagacaaca ccgagtatga gaagtatgat 1620tatcgggaaa tgctgcacaa tgccactttc tgtctggttc ctcgtggtcg caggcttggg 1680tccttcagat tcctggaggc tttgcaggct gcctgcgtcc ctgtgatgct cagcaatgga 1740tgggagttgc cattctctga agtgattaat tggaaccaag ctgccgtcat aggcgatgag 1800agattgttat tacagattcc ttctacaatc aggtctattc atcaggataa aatcctagca 1860cttagacagc agacacaatt cttgtgggag gcttattttt cttcagttga gaagattgta 1920ttaactacac tagagattat tcaggacaga atattcaagc acatatcacg taacagttta 1980atatggaaca aacatcctgg aggattgttc gtactaccac agtattcatc ttatctggga 2040gattttcctt actactatgc taatttaggt ttaaagcccc cctccaaatt cactgcagtc 2100atccatgcgg tgacccccct ggtctctcag tcccagccag tgttgaagct tctcgtggct 2160gcagccaagt cccagtactg tgcccagatc atagttctat ggaattgtga caagccccta 2220ccagccaaac accgctggcc tgccactgct gtgcctgtcg tcgtcattga aggagagagc 2280aaggttatga gcagccgttt tctgccctac gacaacatca tcacagacgc cgtgctcagc 2340cttgacgagg acacggtgct ttcaacaaca gaggtggatt tcgccttcac agtgtggcag 2400agcttccctg agaggattgt ggggtacccc gcgcgcagcc acttctggga taactctaag 2460gagcggtggg gatacacatc aaagtggacg aacgactact ccatggtgtt gacaggagct 2520gctatttacc acaaatatta tcactaccta tactcccatt acctgccagc cagcctgaag 2580aacatggtgg accaattggc caattgtgag gacattctca tgaacttcct ggtgtctgct 2640gtgacaaaat tgcctccaat caaagtgacc cagaagaagc agtataagga gacaatgatg 2700ggacagactt ctcgggcttc ccgttgggct gaccctgacc actttgccca gcgacagagc 2760tgcatgaata cgtttgccag ctggtttggc tacatgccgc tgatccactc tcagatgagg 2820ctcgaccccg tcctctttaa agaccaggtc tctattttga ggaagaaata ccgagacatt 2880gagcgacttt gaggaatccg gctgagtggg ggaggggaag caagaaggga tgggggtcaa 2940gctgctctct cttcccagtg cagatccact catcagcaga gccagattgt gccaactatc 3000caaaaactta gatgagcaga atgacaaaaa aaaaaaaggc caatgagaac tcaactcctg 3060gctcctggga ctgcaccaga ctgctccaaa ctcacctcac tggcttctgt gtcccaagac 3120taggttggta cagtttaatt atggaacatt aaataattat ttttgaaaaa aaaaaaaaaa 3180aaa 3183 17 1016 DNA Homo sapiens 17atggatacca atgttccgac tggagacggg gagcccgcga gacccgggtc tccagggtct 60gcccaaggaa gttgctcatg ggagcagacc cctagagcag gatttgaggc caggccaaag 120agaaccccag agatgaaagg cctcctccca ctggcttggt tcctggcttg tagtgtgcct 180gctgtgcaag gaggcttgct ggacctaaaa tcaatgatcg agaaggtgac agggaagaac 240gccctgacaa actacggctt ctacggctgt tactgcggct ggggcggccg aggaaccccc 300aaggatggca ccgattggtg ctgttgggcg catgaccact gctatgggcg gctggaggag 360aagggctgca acattcgcac acagtcctac aaatacagat tcgcgtgggg cgtggtcacc 420tgcgagcccg ggcccttctg ccatgtgaac ctctgtgcct gtgaccggaa gctcgtctac 480tgcctcaaga gaaacctacg gagctacaac ccacagtacc aatactttcc caacatcctc 540tgctcctagg cctccccagc gagctcctcc cagaccaaga cttttgttct gtttttctac 600aacacagagt actgactctg cctggttcct gagagaggct cctaagtcac agacctcagt 660ctttctcgaa gcttggcgga cccccagggc cacactgtac cctccagcga gtcccaggag 720agtgactctg gtcataggac ttggtagggt cccagggtcc ctaggcctcc acttctgagg 780gcagcccctc tggtgccaag agctctcctc caactcaggg ttggctgtgt ctcttttctt 840ctctgaagac agcgtcctgg ctccagttgg aacactttcc tgagatgcac ttacttctca 900gcttctgcga tcagattatc atcaccacca ccctccagag aattttacgc aagaagagcc 960aaattgactc tctaaatctg gtgtatgggt attaaataaa attcattctc aaggct 1016 18 483 DNA Homo sapiens misc_feature (1)...(483) n = A,T,C or G 18nntttttttt tgtttttaaa aagaattgtt tatttaccga acctggggca tattagatac 60aaccaatttt aaatttacat cttttaaatc agttttgaag tgtttcacac acacaaaaaa 120cttggcatgc aacagttgtc ctaaggtgaa agtcacctca ttaataaact gttgcaagtg 180ttctcaccca aggtggaagt atggtttatc ctgaacatga aaacctgtaa caaatttaaa 240ttaattatat aaaactcgtt acttgtagtt ttgcccttgc aaagatccaa aaaaaaaaaa 300aaaaagcaca agtaactaat atgtatcagt cacaacataa tcctggatca tncccatacc 360aaaaccggat gctcttttaa ttttaaaccc atcatcagag aacaagagaa agtaatttca 420ttttacacaa aacaagattn acatgtgcca aaaaagaaat accccaaaag aaacaaaaac 480caa 483 19 3020 DNA Homo sapiens 19gttcaaggca gcgcccacac ccgggggctc tccgcaaccc gaccgcctgt ccgctccccc 60acttcccgcc ctccctccca cctactcatt cacccaccca cccacccaga gccgggacgg 120cagcccaggc gcccgggccc cgccgtctcc tcgccgcgat cctggacttc ctcttgctgc 180aggacccggc ttccacgtgt gtcccggagc cggcgtctca gcacacgctc cgctccgggc 240ctgggtgcct acagcagcca gagcagcagg gagtccggga cccgggcggc atctgggcca 300agttaggcgc cgccgaggcc agcgctgaac gtctccaggg ccggaggagc cgcggggcgt 360ccgggtctga gcctcagcaa atgggctccg acgtgcggga cctgaacgcg ctgctgcccg 420ccgtcccctc cctgggtggc ggcggcggct gtgccctgcc tgtgagcggc gcggcgcagt 480gggcgccggt gctggacttt gcgcccccgg gcgcttcggc ttacgggtcg ttgggcggcc 540ccgcgccgcc accggctccg ccgccacccc cgccgccgcc gcctcactcc ttcatcaaac 600aggagccgag ctggggcggc gcggagccgc acgaggagca gtgcctgagc gccttcactg 660tccacttttc cggccagttc actggcacag ccggagcctg tcgctacggg cccttcggtc 720ctcctccgcc cagccaggcg tcatccggcc aggccaggat gtttcctaac gcgccctacc 780tgcccagctg cctcgagagc cagcccgcta ttcgcaatca gggttacagc acggtcacct 840tcgacgggac gcccagctac ggtcacacgc cctcgcacca tgcggcgcag ttccccaacc 900actcattcaa gcatgaggat cccatgggcc agcagggctc gctgggtgag cagcagtact 960cggtgccgcc cccggtctat ggctgccaca cccccaccga cagctgcacc ggcagccagg 1020ctttgctgct gaggacgccc tacagcagtg acaatttata ccaaatgaca tcccagcttg 1080aatgcatgac ctggaatcag atgaacttag gagccacctt aaagggagtt gctgctggga 1140gctccagctc agtgaaatgg acagaagggc agagcaacca cagcacaggg tacgagagcg 1200ataaccacac aacgcccatc ctctgcggag cccaatacag aatacacacg cacggtgtct 1260tcagaggcat tcaggatgtg cgacgtgtgc ctggagtagc cccgactctt gtacggtcgg 1320catctgagac cagtgagaaa cgccccttca tgtgtgctta cccaggctgc aataagagat 1380attttaagct gtcccactta cagatgcaca gcaggaagca cactggtgag aaaccatacc 1440agtgtgactt caaggactgt gaacgaaggt tttctcgttc agaccagctc aaaagacacc 1500aaaggagaca tacaggtgtg aaaccattcc agtgtaaaac ttgtcagcga aagttctccc 1560ggtccgacca cctgaagacc cacaccagga ctcatacagg taaaacaagt gaaaagccct 1620tcagctgtcg gtggccaagt tgtcagaaaa agtttgcccg gtcagatgaa ttagtccgcc 1680atcacaacat gcatcagaga aacatgacca aactccagct ggcgctttga ggggtctccc 1740tcggggaccg ttcagtgtcc caggcagcac agtgtgtgaa ctgctttcaa gtctgactct 1800ccactcctcc tcactaaaaa ggaaacttca gttgatcttc ttcatccaac ttccaagaca 1860agataccggt gcttctggaa actaccaggt gtgcctggaa gagttggtct ctgccctgcc 1920tacttttagt tgactcacag gccctggaga agcagctaac aatgtctggt tagttaaaag 1980cccattgcca tttggtctgg attttctact gtaagaagag ccatagctga tcatgtcccc 2040ctgacccttc ccttcttttt ttatgctcgt tttcgctggg gatggaatta ttgtaccatt 2100ttctatcatg gaatatttat aggccagggc atgtgtatgt gtctgctaat gtaaactttg 2160tcatggtttc catttactaa cagcaacagc aagaaataaa tcagagagca aggcatcggg 2220ggtgaatctt gtctaacatt cccgaggtca gccaggctgc taacctggaa agcaggatgt 2280agttctgcca ggcaactttt aaagctcatg catttcaagc agctgaagaa agaatcagaa 2340ctaaccagta cctctgtata gaaatctaaa agaattttac cattcagtta attcaatgtg 2400aacactggca cactgctctt aagaaactat gaagatctga gatttttttg tgtatgtttt 2460tgactctttt gagtggtaat catatgtgtc tttatagatg tacatacctc cttgcacaaa 2520tggaggggaa ttcattttca tcactgggac tgtccttagt gtataaaaac catgctggta 2580tatggcttca agttgtaaaa atgaaagtga ctttaaaaga aaatagggga tggtccagga 2640tctccactga taagactgtt tttaagtaac ttaaggacct ttgggtctac aagtatatgt 2700gaaaaaaatg agacttactg ggtgaggaaa tccattgttt aaagatggtc gtgtgtgtgt 2760gtgtgtgtgt gtgtgtgttg tgttgtgttt tgttttttaa gggagggaat ttattattta 2820ccgttgcttg aaattactgt gtaaatatat gtctgataat gatttgctct ttgacaacta 2880aaattaggac tgtataagta ctagatgcat cactgggtgt tgatcttaca agatattgat 2940gataacactt aaaattgtaa cctgcatttt tcactttgct ctcaattaaa gtctattcaa 3000aaggaaaaaa aaaaaaaaaa 3020 20 13993 DNA Homo sapiens 20atggacccgc cgaggcccgc gctgctggcg ctgctggcgc tgcctgcgct gctgctgctg 60ctgctggcgg gcgccagggc cgaagaggaa atgctggaaa atgtcagcct ggtctgtcca 120aaagatgcga cccgattcaa gcacctccgg aagtacacat acaactatga ggctgagagt 180tccagtggag tccctgggac tgctgattca agaagtgcca ccaggatcaa ctgcaaggtt 240gagctggagg ttccccagct ctgcagcttc atcctgaaga ccagccagtg caccctgaaa 300gaggtgtatg gcttcaaccc tgagggcaaa gccttgctga agaaaaccaa gaactctgag 360gagtttgctg cagccatgtc caggtatgag ctcaagctgg ccattccaga agggaagcag 420gttttccttt acccggagaa agatgaacct acttacatcc tgaacatcaa gaggggcatc 480atttctgccc tcctggttcc cccagagaca gaagaagcca agcaagtgtt gtttctggat 540accgtgtatg gaaactgctc cactcacttt accgtcaaga cgaggaaggg caatgtggca 600acagaaatat ccactgaaag agacctgggg cagtgtgatc gcttcaagcc catccgcaca 660ggcatcagcc cacttgctct catcaaaggc atgacccgcc ccttgtcaac tctgatcagc 720agcagccagt cctgtcagta cacactggac gctaagagga agcatgtggc agaagccatc 780tgcaaggagc aacacctctt cctgcctttc tcctacaaga ataagtatgg gatggtagca 840caagtgacac agactttgaa acttgaagac acaccaaaga tcaacagccg cttctttggt 900gaaggtacta agaagatggg cctcgcattt gagagcacca aatccacatc acctccaaag 960caggccgaag ctgttttgaa gactctccag gaactgaaaa aactaaccat ctctgagcaa 1020aatatccaga gagctaatct cttcaataag ctggttactg agctgagagg cctcagtgat 1080gaagcagtca catctctctt gccacagctg attgaggtgt ccagccccat cactttacaa 1140gccttggttc agtgtggaca gcctcagtgc tccactcaca tcctccagtg gctgaaacgt 1200gtgcatgcca acccccttct gatagatgtg gtcacctacc tggtggccct gatccccgag 1260ccctcagcac agcagctgcg agagatcttc aacatggcga gggatcagcg cagccgagcc 1320accttgtatg cgctgagcca cgcggtcaac aactatcata agacaaaccc tacagggacc 1380caggagctgc tggacattgc taattacctg atggaacaga ttcaagatga ctgcactggg 1440gatgaagatt acacctattt gattctgcgg gtcattggaa atatgggcca aaccatggag 1500cagttaactc cagaactcaa gtcttcaatc ctgaaatgtg tccaaagtac aaagccatca 1560ctgatgatcc agaaagctgc catccaggct ctgcggaaaa tggagcctaa agacaaggac 1620caggaggttc ttcttcagac tttccttgat gatgcttctc cgggagataa gcgactggct 1680gcctatctta tgttgatgag gagtccttca caggcagata ttaacaaaat tgtccaaatt 1740ctaccatggg aacagaatga gcaagtgaag aactttgtgg cttcccatat tgccaatatc 1800ttgaactcag aagaattgga tatccaagat ctgaaaaagt tagtgaaaga agctctgaaa 1860gaatctcaac ttccaactgt catggacttc agaaaattct ctcggaacta tcaactctac 1920aaatctgttt ctcttccatc acttgaccca gcctcagcca aaatagaagg gaatcttata 1980tttgatccaa ataactacct tcctaaagaa agcatgctga aaactaccct cactgccttt 2040ggatttgctt cagctgacct catcgagatt ggcttggaag gaaaaggctt tgagccaaca 2100ttggaggctc cttttgggaa gcaaggattt ttcccagaca gtgtcaacaa agctttgtac 2160tgggttaatg gtcaagttcc tgatggtgtc tctaaggtct tagtggacca ctttggctat 2220accaaagatg ataaacatga gcaggatatg gtaaatggaa taatgctcag tgttgagaag 2280ctgattaaag atttgaaatc caaagaagtc ccggaagcca gagcctacct ccgcatcttg 2340ggagaggagc ttggttttgc cagtctccat gacctccgac tcctgggaaa gctgcttctg 2400atgggtgccc gcactctgca ggggatcccc cagatgattg gagaggtcat caggaagggc 2460tcaaagaatg acttttttct tcactacatc ttcatggaga atgcctttga actccccact 2520ggagctggat tacagttgca aatatcttca tctggagtca ttgctcccgg agccaaggct 2580ggagtaaaac tggaagtagc caacatgcag gctgaactgg tggcaaaacc ctccgtgtct 2640gtggagtttg tgacaaatat gggcatcatc attccggact tcgctaggag tggggtccag 2700atgaacacca acttcttcca cgagtcgggt ctggaggctc atgttgccct aaaagctggg 2760aagctgaagt ttatcattcc ttccccaaag agaccagtca agctgctcag tggaggcaac 2820acattacatt tggtctctac caccaaaacg gaggtcatcc cacctctcat tgagaacagg 2880cagtcctggt cagtttgcaa gcaagtcttt cctggcctga attactgcac ctcaggcgct 2940tactccaacg ccagctccac agactccgcc tcctactatc cgctgaccgg ggacaccaga 3000ttagagctgg aactgaggcc tacaggagag attgagcagt attctgtcag cgcaacctat 3060gagctccaga gagaggacag agccttggtg gataccctga agtttgtaac tcaagcagaa 3120ggcgcgaagc agactgaggc taccatgaca ttcaaatata atcggcagag tatgaccttg 3180tccagtgaag tccaaattcc ggattttgat gttgacctcg gaacaatcct cagagttaat 3240gatgaatcta ctgagggcaa aacgtcttac agactcaccc tggacattca gaacaagaaa 3300attactgagg tcgccctcat gggccaccta agttgtgaca caaaggaaga aagaaaaatc 3360aagggtgtta tttccatacc ccgtttgcaa gcagaagcca gaagtgagat cctcgcccac 3420tggtcgcctg ccaaactgct tctccaaatg gactcatctg ctacagctta tggctccaca 3480gtttccaaga gggtggcatg gcattatgat gaagagaaga ttgaatttga atggaacaca 3540ggcaccaatg tagataccaa aaaaatgact tccaatttcc ctgtggatct ctccgattat 3600cctaagagct tgcatatgta tgctaataga ctcctggatc acagagtccc tcaaacagac 3660atgactttcc ggcacgtggg ttccaaatta atagttgcaa tgagctcatg gcttcagaag 3720gcatctggga gtcttcctta tacccagact ttgcaagacc acctcaatag cctgaaggag 3780ttcaacctcc agaacatggg attgccagac tcccacatcc cagaaaacct cttcttaaaa 3840agcgatggcc gcgtcaaata taccttgaac aagaacagtt tgaaaattga gattcctttg 3900ccttttggtg gcaaatcctc cagagatcta aagatgttag agactgttag gacaccagcc 3960ctccacttca agtctgtggg attccatctg ccatctcgag agttccaagt ccctactttt 4020accattccca agttgtatca actgcaagtg cctctcctgg gtgttctaga cctctccacg 4080aatgtctaca gcaacttgta caactggtcc gcctcctaca gtggtggcaa caccagcaca 4140gaccatttca gccttcgggc tcgttaccac atgaaggctg actctgtggt tgacctgctt 4200tcctacaatg tgcaaggatc tggagaaaca acatatgacc acaagaatac gttcacacta 4260tcatgtgatg ggtctctacg ccacaaattt ctagattcga atatcaaatt cagtcatgta 4320gaaaaacttg gaaacaaccc agtctcaaaa ggtttactaa tattcgatgc atctagttcc 4380tggggaccac agatgtctgc ttcagttcat ttggactcca aaaagaaaca gcatttgttt 4440gtcaaagaag tcaagattga tgggcagttc agagtctctt cgttctatgc taaaggcaca 4500tatggcctgt cttgtcagag ggatcctaac actggccggc tcaatggaga gtccaacctg 4560aggtttaact cctcctacct ccaaggcacc aaccagataa caggaagata tgaagatgga 4620accctctccc tcacctccac ctctgatctg caaagtggca tcattaaaaa tactgcttcc 4680ctaaagtatg agaactacga gctgacttta aaatctgaca ccaatgggaa gtataagaac 4740tttgccactt ctaacaagat ggatatgacc ttctctaagc aaaatgcact gctgcgttct 4800gaatatcagg ctgattacga gtcattgagg ttcttcagcc tgctttctgg atcactaaat 4860tcccatggtc ttgagttaaa tgctgacatc ttaggcactg acaaaattaa tagtggtgct 4920cacaaggcga cactaaggat tggccaagat ggaatatcta ccagtgcaac gaccaacttg 4980aagtgtagtc tcctggtgct ggagaatgag ctgaatgcag agcttggcct ctctggggca 5040tctatgaaat taacaacaaa tggccgcttc agggaacaca atgcaaaatt cagtctggat 5100gggaaagccg ccctcacaga gctatcactg ggaagtgctt atcaggccat gattctgggt 5160gtcgacagca aaaacatttt caacttcaag gtcagtcaag aaggacttaa gctctcaaat 5220gacatgatgg gctcatatgc tgaaatgaaa tttgaccaca caaacagtct gaacattgca 5280ggcttatcac tggacttctc ttcaaaactt gacaacattt acagctctga caagttttat 5340aagcaaactg ttaatttaca gctacagccc tattctctgg taactacttt aaacagtgac 5400ctgaaataca atgctctgga tctcaccaac aatgggaaac tacggctaga acccctgaag 5460ctgcatgtgg ctggtaacct aaaaggagcc taccaaaata atgaaataaa acacatctat 5520gccatctctt ctgctgcctt atcagcaagc tataaagcag acactgttgc taaggttcag 5580ggtgtggagt ttagccatgg gctcaacaca gacatcgctg ggctggcttc agccattgac 5640atgagcacaa actataattc agactcactg catttcagca atgtcttccg ttctgtaatg 5700gccccgttta ccatgaccat cgatgcacat acaaatggca atgggaaact cgctctctgg 5760ggagaacata ctgggcagct gtatagcaaa ttcctgttga aagcagaacc tctggcattt 5820actttctctc atgattacaa aggctccaca agtcatcatc tcgtgtctag gaaaagcatc 5880agtgcagctc ttgaacacaa agtcagtgcc ctgcttactc cagctgagca gacaggcacc 5940tggaaactca agacccaatt taacaacaat gaatacagcc aggacttgga tgcttacaac 6000actaaagata aaattggcgt ggagcttact ggacgaactc tggctgacct aactctacta 6060gactccccaa ttaaagtgcc acttttactc agtgagccca tcaatatcaa tgatgcttta 6120gagatgagag atgccgttga gaagccccaa gaatttacaa ttgttgcttt tgtaaagtat 6180gataaaaacc aagatgttca ctccattaac ctcccatttt ttgagacctt gcaagaatat 6240tttgagagga atcgacaaac cattatagtt gtactggaaa acgtacagag aaacctgaag 6300cacatcaata ttgatcaatt tgtaagaaaa tacagagcag ccctgggaaa actcccacag 6360caagctaatg attatctgaa ttcattcaat tgggagagac aagtttcaca tgccaaggag 6420aaactgactg ctctcacaaa aaagtataga attacagaaa atgatataca aattgcatta 6480gatgatgcca aaatcaactt taatgaaaaa ctatctcaac tgcagacata tatgatacaa 6540tttgatcagt atattaaaga tagttatgat ttacatgatt tgaaaatagc tattgctaat 6600attattgatg aaatcattga aaaattaaaa agtcttgatg agcactatca tacccgtgta 6660aatttagtaa aaacaatcca tgatctacat ttgtttattg aaaatattga ttttaacaaa 6720agtggaagta gtactgcatc ctggattcaa aatgtggata ctaagtacca aatcagaatc 6780cagatacaag aaaaactgca gcagcttaag agacacatac agaatataga catccagcac 6840ctagctggaa agttaaaaca acacattgag gctattgatg ttagagtgct tttagatcaa 6900ttgggaacta caatttcatt tgaaagaata aatgatgttc ttgagcatgt caaacacttt 6960gttataaatc ttattgggga ttttgaagta gctgagaaaa tcaatgcctt cagagccaaa 7020gtccatgagt taatcgagag gtatgaagta gaccaacaaa tccaggtttt aatggataaa 7080ttagtagagt tggcccacca atacaagttg aaggagacta ttcagaagct aagcaatgtc 7140ctacaacaag ttaagataaa agattacttt gagaaattgg ttggatttat tgatgatgct 7200gtcaagaagc ttaatgaatt atcttttaaa acattcattg aagatgttaa caaattcctt 7260gacatgttga taaagaaatt aaagtcattt gattaccacc agtttgtaga tgaaaccaat 7320gacaaaatcc gtgaggtgac tcagagactc aatggtgaaa ttcaggctct ggaactacca 7380caaaaagctg aagcattaaa actgttttta gaggaaacca aggccacagt tgcagtgtat 7440ctggaaagcc tacaggacac caaaataacc ttaatcatca attggttaca ggaggcttta 7500agttcagcat ctttggctca catgaaggcc aaattccgag agactctaga agatacacga 7560gaccgaatgt atcaaatgga cattcagcag gaacttcaac gatacctgtc tctggtaggc 7620caggtttata gcacacttgt cacctacatt tctgattggt ggactcttgc tgctaagaac 7680cttactgact ttgcagagca atattctatc caagattggg ctaaacgtat gaaagcattg 7740gtagagcaag ggttcactgt tcctgaaatc aagaccatcc ttgggaccat gcctgccttt 7800gaagtcagtc ttcaggctct tcagaaagct accttccaga cacctgattt tatagtcccc 7860ctaacagatt tgaggattcc atcagttcag ataaacttca aagacttaaa aaatataaaa 7920atcccatcca ggttttccac accagaattt accatcctta acaccttcca cattccttcc 7980tttacaattg actttgtaga aatgaaagta aagatcatca gaaccattga ccagatgctg 8040aacagtgagc tgcagtggcc cgttccagat atatatctca gggatctgaa ggtggaggac 8100attcctctag cgagaatcac cctgccagac ttccgtttac cagaaatcgc aattccagaa 8160ttcataatcc caactctcaa ccttaatgat tttcaagttc ctgaccttca cataccagaa 8220ttccagcttc cccacatctc acacacaatt gaagtaccta cttttggcaa gctatacagt 8280attctgaaaa tccaatctcc tcttttcaca ttagatgcaa atgctgacat agggaatgga 8340accacctcag caaacgaagc aggtatcgca gcttccatca ctgccaaagg agagtccaaa 8400ttagaagttc tcaattttga ttttcaagca aatgcacaac tctcaaaccc taagattaat 8460ccgctggctc tgaaggagtc agtgaagttc tccagcaagt acctgagaac ggagcatggg 8520agtgaaatgc tgttttttgg aaatgctatt gagggaaaat caaacacagt ggcaagttta 8580cacacagaaa aaaatacact ggagcttagt aatggagtga ttgtcaagat aaacaatcag 8640cttaccctgg atagcaacac taaatacttc cacaaattga acatccccaa actggacttc 8700tctagtcagg ctgacctgcg caacgagatc aagacactgt tgaaagctgg ccacatagca 8760tggacttctt ctggaaaagg gtcatggaaa tgggcctcgc ccagattctc agatgaggga 8820acacatgaat cacaaattag tttcaccata gaaggacccc tcacttcctt tggactgtcc 8880aataagatca atagcaaaca cctaagagta aaccaaaact tggtttatga atctggctcc 8940ctcaactttt ctaaacttga aattcaatca caagtcgatt cccagcatgt gggccacagt 9000gttctaactg ctaaaggcat ggcactgttt ggagaaggga aggcagagtt tactgggagg 9060catgatgctc atttaaatgg aaaggttatt ggaactttga aaaattctct tttcttttca 9120gcccagccat ttgagatcac ggcatccaca aacaatgaag ggaatttgaa agttcgtttt 9180ccattaaggt taacagggaa gatagacttc ctgaataact atgcactgtt tctgagtccc 9240agtgcccagc aagcaagttg gcaagtaagt gctaggttca atcagtataa gtacaaccaa 9300aatttctctg ctggaaacaa cgagaacatt atggaggccc atgtaggaat aaatggagaa 9360gcaaatctgg atttcttaaa cattccttta acaattcctg aaatgcgtct accttacaca 9420ataatcacaa ctcctccact gaaagatttc tctctatggg aaaaaacagg cttgaaggaa 9480ttcttgaaaa cgacaaagca atcatttgat ttaagtgtaa aagctcagta taagaaaaac 9540aaacacaggc attccatcac aaatcctttg gctgtgcttt gtgagtttat cagtcagagc 9600atcaaatcct ttgacaggca ttttgaaaaa aacagaaaca atgcattaga ttttgtcacc 9660aaatcctata atgaaacaaa aattaagttt gataagtaca aagctgaaaa atctcacgac 9720gagctcccca ggacctttca aattcctgga tacactgttc cagttgtcaa tgttgaagtg 9780tctccattca ccatagagat gtcggcattc ggctatgtgt tcccaaaagc agtcagcatg 9840cctagtttct ccatcatagg ttctgacgtc cgtgtgcctt catacacatt aatcctgcca 9900tcattagagc tgccagtcct tcatgtccct agaaatctca agctttctct tccagatttc 9960aaggaattgt gtaccataag ccatattttt attcctgcca tgggcaatat tacctatgat 10020ttctccttta aatcaagtgt catcacactg aataccaatg ctgaactttt taaccagtca 10080gatattgttg ctcatctcct ttcttcatct tcatctgtca ttgatgcact gcagtacaaa 10140ttagagggca ccacaagatt gacaagaaaa aggggattga agttagccac agctctgtct 10200ctgagcaaca aatttgtgga gggtagtcat aacagtactg tgagcttaac cacgaaaaat 10260atggaagtgt cagtggcaaa aaccacaaaa ccggaaattc caattttgag aatgaatttc 10320aagcaagaac ttaatggaaa taccaagtca aaacctactg tctcttcctc catggaattt 10380aagtatgatt tcaattcttc aatgctgtac tctaccgcta aaggagcagt tgaccacaag 10440cttagcttgg aaagcctcac ctcttacttt tccattgagt catctaccaa aggagatgtc 10500aagggttcgg ttctttctcg ggaatattca ggaactattg ctagtgaggc caacacttac 10560ttgaattcca agagcacacg gtcttcagtg aagctgcagg gcacttccaa aattgatgat 10620atctggaacc ttgaagtaaa agaaaatttt gctggagaag ccacactcca acgcatatat 10680tccctctggg agcacagtac gaaaaaccac ttacagctag agggcctctt tttcaccaac 10740ggagaacata caagcaaagc caccctggaa ctctctccat ggcaaatgtc agctcttgtt 10800caggtccatg caagtcagcc cagttccttc catgatttcc ctgaccttgg ccaggaagtg 10860gccctgaatg ctaacactaa gaaccagaag atcagatgga aaaatgaagt ccggattcat 10920tctgggtctt tccagagcca ggtcgagctt tccaatgacc aagaaaaggc acaccttgac 10980attgcaggat ccttagaagg acacctaagg ttcctcaaaa atatcatcct accagtctat 11040gacaagagct tatgggattt cctaaagctg gatgtcacca ccagcattgg taggagacag 11100catcttcgtg tttcaactgc ctttgtgtac accaaaaacc ccaatggcta ttcattctcc 11160atccctgtaa aagttttggc tgataaattc attattcctg ggctgaaact aaatgatcta 11220aattcagttc ttgtcatgcc tacgttccat gtcccattta cagatcttca ggttccatcg 11280tgcaaacttg acttcagaga aatacaaatc tataagaagc tgagaacttc atcatttgcc 11340ctcaccctac caacactccc cgaggtaaaa ttccctgaag ttgatgtgtt aacaaaatat 11400tctcaaccag aagactcctt gattcccttt tttgagataa ccgtgcctga atctcagtta 11460actgtgtccc agttcacgct tccaaaaagt gtttcagatg gcattgctgc tttggatcta 11520aatgcagtag ccaacaagat cgcagacttt gagttgccca ccatcatcgt gcctgagcag 11580accattgaga ttccctccat taagttctct gtacctgctg gaattgtcat tccttccttt 11640caagcactga ctgcacgctt tgaggtagac tctcccgtgt ataatgccac ttggagtgcc 11700agtttgaaaa acaaagcaga ttatgttgaa acagtcctgg attccacatg cagctcaacc 11760gtacagttcc tagaatatga actaaatgtt ttgggaacac acaaaatcga agatggtacg 11820ttagcctcta agactaaagg aacacttgca caccgtgact tcagtgcaga atatgaagaa 11880gatggcaaat atgaaggact tcaggaatgg gaaggaaaag cgcacctcaa tatcaaaagc 11940ccagcgttca ccgatctcca tctgcgctac cagaaagaca agaaaggcat ctccacctca 12000gcagcctccc cagccgtagg caccgtgggc atggatatgg atgaagatga cgacttttct 12060aaatggaact tctactacag ccctcagtcc tctccagata aaaaactcac catattcaaa 12120actgagttga gggtccggga atctgatgag gaaactcaga tcaaagttaa ttgggaagaa 12180gaggcagctt ctggcttgct aacctctctg aaagacaacg tgcccaaggc cacaggggtc 12240ctttatgatt atgtcaacaa gtaccactgg gaacacacag ggctcaccct gagagaagtg 12300tcttcaaagc tgagaagaaa tctgcagaac aatgctgagt gggtttatca aggggccatt 12360aggcaaattg atgatatcga cgtgaggttc cagaaagcag ccagtggcac cactgggacc 12420taccaagagt ggaaggacaa ggcccagaat ctgtaccagg aactgttgac tcaggaaggc 12480caagccagtt tccagggact caaggataac gtgtttgatg gcttggtacg agttactcaa 12540aaattccata tgaaagtcaa gaagctgatt gactcactca ttgattttct gaacttcccc 12600agattccagt ttccggggaa acctgggata tacactaggg aggaactttg cactatgttc 12660atgagggagg tagggacggt actgtcccag gtatattcga aagtccataa tggttcagaa 12720atactgtttt cctatttcca agacctagtg attacacttc ctttcgagtt aaggaaacat 12780aaactaatag atgtaatctc gatgtatagg gaactgttga aagatttatc aaaagaagcc 12840caagaggtat ttaaagccat tcagtctctc aagaccacag aggtgctacg taatcttcag 12900gaccttttac aattcatttt ccaactaata gaagataaca ttaaacagct gaaagagatg 12960aaatttactt atcttattaa ttatatccaa gatgagatca acacaatctt caatgattat 13020atcccatatg tttttaaatt gttgaaagaa aacctatgcc ttaatcttca taagttcaat 13080gaatttattc aaaacgagct tcaggaagct tctcaagagt tacagcagat ccatcaatac 13140attatggccc ttcgtgaaga atattttgat ccaagtatag ttggctggac agtgaaatat 13200tatgaacttg aagaaaagat agtcagtctg atcaagaacc tgttagttgc tcttaaggac 13260ttccattctg aatatattgt cagtgcctct aactttactt cccaactctc aagtcaagtt 13320gagcaatttc tgcacagaaa tattcaggaa tatcttagca tccttaccga tccagatgga 13380aaagggaaag agaagattgc agagctttct gccactgctc aggaaataat taaaagccag 13440gccattgcga cgaagaaaat aatttctgat taccaccagc agtttagata taaactgcaa 13500gatttttcag accaactctc tgattactat gaaaaattta ttgctgaatc caaaagattg 13560attgacctgt ccattcaaaa ctaccacaca tttctgatat acatcacgga gttactgaaa 13620aagctgcaat caaccacagt catgaacccc tacatgaagc ttgctccagg agaacttact 13680atcatcctct aattttttta aaagaaatct tcatttattc ttcttttcca attgaacttt 13740cacatagcac agaaaaaatt caaactgcct atattgataa aaccatacag tgagccagcc 13800ttgcagtagg cagtagacta taagcagaag cacatatgaa ctggacctgc accaaagctg 13860gcaccagggc tcggaaggtc tctgaactca gaaggatggc attttttgca agttaaagaa 13920aatcaggatc tgagttattt tgctaaactt gggggaggag gaacaaataa atggagtctt 13980tattgtgtat cat 13993 21 1965 DNA Homo sapiens 21caattccggg ccgccccgga gaccacctcc tcctcctcgt cgtcgtcctc cgcctcctgc 60gcctcgtcct cgtcctcctc caattcggcc agcgccccct cggctgcctg caagagcgcg 120ggcggcggcg gcgcgggcgc cgggagcggg ggcgccaaga aggcgagctc ggggctgcgg 180cggcccgaga agccgcccta ctcgtacatc gcgctcatcg tcatggccat ccagagctcg 240cccagcaagc gcctgacgct cagcgagatc taccagttcc tgcaggcgcg cttccccttc 300ttccgcggcg cctaccaggg ctggaagaac tcggtgcgcc acaatctctc gctcaacgag 360tgcttcatca agctgcctaa gggcctcggg cggcccggca agggccacta ctggaccatc 420gacccggcca gcgagttcat gttcgaggag ggctcgttcc gccgccggcc gcgcggcttc 480aggcggaagt gccaggcgct caagcccatg taccaccgcg tggtgagcgg cttgggcttc 540ggggcgtcgc tgctgcccca gggcttcgac ttccaggcgc ccccgtcggc gccgctcggc 600tgccacagcc agggcggcta cggcggcctc gacatgatgc ccgcgggcta cgacgccggc 660gcgggcgccc ccagccacgc gcaccctcac caccaccacc accaccacgt cccgcacatg 720tcgcccaacc cgggttccac ctacatggcc agctgcccgg tgcccgcggg acccgggggc 780gtcggtgcgg ccgggggcgg cggcggcggc gactacgggc cggacagcag cagcagcccg 840gtaccctcgt ccccggccat ggcgagcgcc atcgaatgcc actcgcccta cacgagccct 900gcggcgcact ggagctcgcc tggcgcctcg ccttacctca agcagccgcc tgccctgacg 960cccagcagca accccgccgc ctcggcaggc ctgcactcca gcatgtcctc ctactcgctg 1020gagcagagct acttgcacca gaacgctcgc gaggacctct cagtgggact gccccgttac 1080cagcatcact ctactccagt gtgtgacaga aaagatttcg tcctcaactt caatgggatt 1140tcttctttcc atccctcagc tagcgggtcg tattatcacc atcaccacca gagcgtctgt 1200caggatatta agccctgcgt catgtgaacg gaaagaggcc aagcgatggc cgctctctcc 1260tctcccctcc tcagaggggg cagatagaaa ctgggacgga ttcaagtcac atgcacgcgg 1320atagcagtaa gccacacacc tgccacttag ccagaatgcc caggatcgcg ttggtcactg 1380ttatttgcct actgctggaa gaaggacaac cgctggcaag gtagcgttcc ccaatctgaa 1440tacctgcagg ctcccacatg agggagaggg cagactcagg tgggaagatg tgccatgcgt 1500aaggcatcaa cgtgtatctg tgggatcttc gttgccttca gtaatcaggg tgtgaaaaaa 1560gcagacaagt tgtgtgtgtg tgtgtgtgtc taagaaaact tgtgtgcttt tcaaaaaggc 1620agtgctaagc acaagatttc aagaaagcct cttcttgttg cctagctgag tgggagagtc 1680attttcccca gacactacat ttggatacag gtgccaaaga acattattaa ggaattattt 1740agaaacaatg tgtctagttt aagaaagtgg ttttcagtat tgtgacaata caacgttttt 1800acaaggttgt tttctaccac catattttaa agatattttt atgaccgtgt atactcacac 1860tttgcttgta ttttaaaagg aggatatatt tgcacttatg tatactttta cagtttgcca 1920aaatattttg ttgtaaaatt ttttttcaat aaaatgtata taaca 1965 22 1805 DNA Homo sapiens 22aagagactga actgtatctg cctctatttc caaaagactc acgttcaact ttcgctcaca 60caaagccggg aaaattttat tagtcctttt tttaaaaaaa gttaatataa aattatagca 120aaaaaaaaaa ggaacctgaa ctttagtaac acagctggaa caatcgcagc ggcggcggca 180gcggcgggag aagaggttta atttagttga ttttctgtgg ttgttggttg ttcgctagtc 240tcacggtgat ggaagctgca cattttttcg aagggaccga gaagctgctg gaggtttggt 300tctcccggca gcagcccgac gcaaaccaag gatctgggga tcttcgcact atcccaagat 360ctgagtggga catacttttg aaggatgtgc aatgttcaat cataagtgtg acaaaaactg 420acaagcagga agcttatgta ctcagtgaga gtagcatgtt tgtctccaag agacgtttca 480ttttgaagac atgtggtacc accctcttgc tgaaagcact ggttcccctg ttgaagcttg 540ctagggatta cagtgggttt gactcaattc aaagcttctt ttattctcgt aagaatttca 600tgaagccttc tcaccaaggg tacccacacc ggaatttcca ggaagaaata gagtttctta 660atgcaatttt cccaaatgga gcaggatatt gtatgggacg tatgaattct gactgttggt 720acttatatac tctggatttc ccagagagtc gggtaatcag tcagccagat caaaccttgg 780aaattctgat gagtgagctt gacccagcag ttatggacca gttctacatg aaagatggtg 840ttactgcaaa ggatgtcact cgtgagagtg gaattcgtga cctgatacca ggttctgtca 900ttgatgccac aatgttcaat ccttgtgggt attcgatgaa tggaatgaaa tcggatggaa 960cttattggac tattcacatc actccagaac cagaattttc ttatgttagc tttgaaacaa 1020acttaagtca gacctcctat gatgacctga tcaggaaagt tgtagaagtc ttcaagccag 1080gaaaatttgt gaccaccttg tttgttaatc agagttctaa atgtcgcaca gtgcttgctt 1140cgccccagaa gattgaaggt tttaagcgtc ttgattgcca gagtgctatg ttcaatgatt 1200acaattttgt ttttaccagt tttgctaaga agcagcaaca acagcagagt tgattaagaa 1260aaatgaagaa aaaacgcaaa aagagaacac atgtagaagg tggtggatgc tttctagatg 1320tcgatgctgg gggcagtgct ttccataacc accactgtgt agttgcagaa agccctagat 1380gtaatgatag tgtaatcatt ttgaattgta tgcattatta tatcaaggag ttagatatct 1440tgcatgaatg ctctcttctg tgtttaggta ttctctgcca ctcttgctgt gaaattgaag 1500tggatgtaga aaaaaccttt tactatatga aactttacaa cacttgtgaa agcaactcaa 1560tttggtttat gcacagtgta atatttctcc aagtatcatc caaaattccc cacagacaag 1620gctttcgtcc tcattaggtg ttggcctcag cctaaccctc taggactgtt ctattaaatt 1680gctgccagaa ttttacatcc agttacctcc actttctaga acatattctt tactaatgtt 1740attgaaacca atttctactt catactgatg tttttggaaa cagcaattaa agtttttctt 1800ccatg 1805 23 3741 DNA Homo sapiens 23gaattccgtc atggcgtcgc agccaaattc gtctgcgaag aagaaagagg agaaggggaa 60gaacatccag gtggtggtga gatgcagacc atttaatttg gcagagcgga aagctagcgc 120ccattcaata gtagaatgtg atcctgtacg aaaagaagtt agtgtacgaa ctggaggatt 180ggctgacaag agctcaagga aaacatacac ttttgatatg gtgtttggag catctactaa 240acagattgat gtttaccgaa gtgttgtttg tccaattctg gatgaagtta ttatgggcta 300taattgcact atctttgcgt atggccaaac tggcactgga aaaactttta caatggaagg 360tgaaaggtca cctaatgaag agtatacctg ggaagaggat cccttggctg gtataattcc 420acgtaccctt catcaaattt ttgagaaact tactgataat ggtactgaat tttcagtcaa 480agtgtctctg ttggagatct ataatgaaga gctttttgat cttcttaatc catcatctga 540tgtttctgag agactacaga tgtttgatga tccccgtaac aagagaggag tgataattaa 600aggtttagaa gaaattacag tacacaacaa ggatgaagtc tatcaaattt tagaaaaggg 660ggcagcaaaa aggacaactg cagctactct gatgaatgca tactctagtc gttcccactc 720agttttctct gttacaatac atatgaaaga aactacgatt gatggagaag agcttgttaa 780aatcggaaag ttgaacttgg ttgatcttgc aggaagtgaa aacattggcc gttctggagc 840tgttgataag agagctcggg aagctggaaa tataaatcaa tccctgttga ctttgggaag 900ggtcattact gcccttgtag aaagaacacc tcatgttcct tatcgagaat ctaaactaac 960tagaatcctc caggattctc ttggagggcg tacaagaaca tctataattg caacaatttc 1020tcctgcatct ctcaatcttg aggaaactct gagtacattg gaatatgctc atagagcaaa 1080gaacatattg aataagcctg aagtgaatca gaaactcacc aaaaaagctc ttattaagga 1140gtatacggag gagatagaac gtttaaaacg agatcttgct gcagcccgtg agaaaaatgg 1200agtgtatatt tctgaagaaa attttagagt catgagtgga aaattaactg ttcaagaaga 1260gcagattgta gaattgattg aaaaaattgg tgctgttgag gaggagctga atagggttac 1320agagttgttt atggataata aaaatgaact tgaccagtgt aaatctgacc tgcaaaataa 1380aacacaagaa cttgaaacca ctcaaaaaca tttgcaagaa actaaattac aacttgttaa 1440agaagaatat atcacatcag ctttggaaag tactgaggag aaacttcatg atgctgccag 1500caagctgctt aacacagttg aagaaactac aaaagatgta tctggtctcc attccaaact 1560ggatcgtaag aaggcagttg accaacacaa tgcagaagct caggatattt ttggcaaaaa 1620cctgaatagt ctgtttaata atatggaaga attaattaag gatggcagct caaagcaaaa 1680ggccatgcta gaagtacata agaccttatt tggtaatctg ctgtcttcca gtgtctctgc 1740attagatacc attactacag tagcacttgg atctctcaca tctattccag aaaatgtgtc 1800tactcatgtt tctcagattt ttaatatgat actaaaagaa caatcattag cagcagaaag 1860taaaactgta ctacaggaat tgattaatgt actcaagact gatcttctaa gttcactgga 1920aatgatttta tccccaactg tggtgtctat actgaaaatc aatagtcaac taaagcatat 1980tttcaagact tcattgacag tggccgataa gatagaagat caaaaaaaaa ggaactcaga 2040tggctttctc agtatactgt gtaacaatct acatgaacta caagaaaata ccatttgttc 2100cttggttgag tcacaaaagc aatgtggaaa cctaactgaa gacctgaaga caataaagca 2160gacccattcc caggaacttt gcaagttaat gaatctttgg acagagagat tctgtgcttt 2220ggaggaaaag tgtgaaaata tacagaaacc acttagtagt gtccaggaaa atatacagca 2280gaaatctaag gatatagtca acaaaatgac ttttcacagt caaaaatttt gtgctgattc 2340tgatggcttc tcacaggaac tcagaaattt taaccaagaa ggtacaaaat tggttgaaga 2400atctgtgaaa cactctgata aactcaatgg caacctggaa aaaatatctc aagagactga 2460acagagatgt gaatctctga acacaagaac agtttatttt tctgaacagt gggtatcttc 2520cttaaatgaa agggaacagg aacttcacaa cttattggag gttgtaagcc aatgttgtga 2580ggcttcaagt tcagacatca ctgagaaatc agatggacgt aaggcagctc atgagaaaca 2640gcataacatt tttcttgatc agatgactat tgatgaagat aaattgatag cacaaaatct 2700agaacttaat gaaaccataa aaattggttt gactaagctt aattgctttc tggaacagga 2760tctgaaactg gatatcccaa caggtacgac accacagagg aaaagttatt tatacccatc 2820aacactggta agaactgaac cacgtgaaca tctccttgat cagctgaaaa ggaaacagcc 2880tgagctgtta atgatgctaa actgttcaga aaacaacaaa gaagagacaa ttccggatgt 2940ggatgtagaa gaggcagttc tggggcagta tactgaagaa cctctaagtc aagagccatc 3000tgtagatgct ggtgtggatt gttcatcaat tggcggggtt ccatttttcc agcataaaaa 3060atcacatgga aaagacaaag aaaacagagg cattaacaca ctggagaggt ctaaagtgga 3120agaaactaca gagcacttgg ttacaaagag cagattacct ctgcgagccc agatcaacct 3180ttaattcact tgggggttgg caattttatt tttaaagaaa aacttaaaaa taaaacctga 3240aaccccagaa cttgagcctt gtgtatagat tttaaaagaa tatatatatc agccgggcgc 3300gtggctctag ctgtaatccc agctaacttt ggaggctgag gcgggtggat tgcttgagcc 3360caggagtttg agaccagcct ggccaacgtg cgctaaaacc ttcgtctctg ttaaaaatta 3420gccgggcgtg gtgggcacac tcctgtaatc ccagctactg gggaggctga ggcacgagaa 3480tcacttgaac ccagaagcgg ggttgcagtg agccaaaggt acaccactac actccagcct 3540gggcaacaga gcaagactcg gtctcaaaaa taaaatttaa aaaagatata aggcagtact 3600gtaaattcag ttgaattttg atatctaccc atttttctgt catccctata gttcactttg 3660tattaaattg ggtttcattt gggatttgca atgtaaatac gtatttctag ttttcatata 3720aagtagttct tttaggaatt c 3741 24 7672 DNA Homo sapiens 24gaggctcctc ggtccttcag cacccctcgg cccgacgcac ccacgcccct caccccccga 60gagccgaaaa tggacccaag tggggtcaaa gtgctggaaa cagcagagga catccaggag 120aggcggcagc aggtcctaga ccgataccac cgcttcaagg aactctcaac ccttaggcgt 180cagaagctgg aagattccta tcgattccag ttctttcaaa gagatgctga agagctggag 240aaatggatac aggaaaaact tcagattgca tctgatgaga attataaaga cccaaccaac 300ttgcagggaa agcttcagaa gcatcaagca tttgaagctg aagtgcaggc caactcagga 360gccattgtta agctggatga aactggaaac ctgatgatct cagaagggca ttttgcatct 420gaaaccatac ggacccgttt gatggagctg caccgccagt gggaattact tttggagaag 480atgcgagaaa aaggaatcaa actgctgcag gcccagaagt tggtgcagta cttacgagaa 540tgtgaggacg tgatggactg gatcaatgac aaggaagcaa ttgttacttc tgaagagctg 600ggccaggatc tggagcatgt agaggtttta cagaagaaat ttgaagagtt tcaaacagat 660atggctgctc atgaagaaag agttaatgaa gtgaaccagt ttgctgccaa actcatacag 720gagcagcacc ctgaggagga actgatcaag actaagcagg atgaagtcaa tgcagcctgg 780cagcggctga agggcctggc tctgcagagg caggggaagc tctttggggc agcagaagtt 840cagcgcttta acagggatgt ggatgagact atcagttgga ttaaggaaaa ggagcagtta 900atggcctctg atgattttgg ccgagacctg gcaagtgttc aggctctgct tcggaagcac 960gagggtctgg agagagatct tgctgctcta gaagacaagg tcaaagccct gtgtgctgag 1020gctgaccgcc tgcaacagtc ccaccctctg agtgcaacac agattcaagt gaagcgagag 1080gaactgatta caaactggga gcagatccgc accttggcgg cagagagaca tgcacggctc 1140aatgattcat acaggcttca acgcttcctt gctgacttcc gtgacctcac cagctgggtg 1200actgagatga aagccctcat caatgcagat gagcttgcca gtgatgtggc tggggctgaa 1260gccctgctag atagacacca agagcacaag ggtgaaattg atgcccatga agacagcttc 1320aaatctgcag atgaatctgg acaggcactg cttgctgctg gtcactatgc ctcagatgaa 1380gtgagggaga agctgaccgt cctttccgag gagagagcgg cgctgctgga gctgtgggag 1440ctgcgcaggc agcagtacga gcagtgcatg gacctgcagc tcttctaccg ggacactgag 1500caggtggaca actggatgag caagcaggag gcgttcctgt tgaatgaaga cttgggagat 1560tccttggata gtgtggaagc gcttcttaag aagcacgaag actttgagaa atcccttagt 1620gcccaggagg aaaagattac agcattagat gaatttgcaa ccaagctaat tcagaacaac 1680cactatgcaa tggaagatgt ggccactcgc cgagatgctc tgttgagccg ccgcaatgcc 1740cttcacgaga gagccatgcg tcgccgggcc cagctagccg attctttcca tctgcagcag 1800tttttccgtg attctgatga gctcaagagt tgggtcaatg agaagatgaa aactgccaca 1860gatgaagctt ataaagatcc atccaaccta caaggaaaag tacagaagca tcaggctttt 1920gaggctgagc tctcagcaaa ccagagccga attgatgcct tggagaaagc tggccaaaag 1980ctgattgatg tcaaccacta tgccaaggat gaagtggcag ctcgtatgaa tgaggtgatc 2040agtttgtgga agaaactgct agaggccact gaactgaaag gaataaagct tcgtgaagcc 2100aaccagcaac agcaatttaa tcgcaatgtt gaggatattg aattgtggct atatgaagta 2160gaaggtcact tggcttcgga tgattacggc aaagatctta ccaatgtgca gaacctccag 2220aagaaacatg ccctgctaga ggcagatgtg gctgctcacc aggaccgaat tgatggcatc 2280accattcagg cccgccagtt ccaagatgct ggccattttg atgcagaaaa catcaagaag 2340aaacaggaag ccctcgtggc tcgctatgag gcactcaagg agcccatggt tgcccggaag 2400cagaagctgg ccgattctct gcggttgcag cagctcttcc gggatgttga ggatgaggag 2460acgtggattc gagagaaaga gcccattgcc gcatctacca acagaggtaa ggatttaatt 2520ggggtccaga atctgctaaa gaaacatcaa gccttacaag cagaaattgc tggacatgaa 2580ccacgcatca aagcagttac acagaagggg aatgccatgg tggaggaagg ccattttgct 2640gcagaggatg tgaaggccaa gcttcacgag ctgaaccaaa agtgggaggc actgaaagcc 2700aaagcttccc agcgtcggca ggacctggag gactctctgc aggcccagca gtactttgct 2760gatgctaacg aggctgaatc ctggatgcgg gagaaggaac ccattgtggg cagcactgac 2820tatggcaagg acgaagactc tgctgaggct ctactgaaga aacacgaagc tttgatgtca 2880gatctcagtg cctacggcag cagcatccag gctttgcgag aacaagcaca gtcctgccgg 2940caacaagtgg cccccacgga tgatgagact gggaaggagc tggtcttggc tctctacgac 3000tatcaggaga agagtccccg agaggtcacc atgaagaagg gagatatcct taccttactc 3060aacagcacca acaaggattg gtggaaagtg gaagtgaacg atcgtcaggg ttttgtgccg 3120gctgcgtacg tgaagaaatt ggaccccgcc cagtcagcct cccgggagaa tctcctggag 3180gagcaaggca gcatagcact gcggcaggag cagattgaca atcagacacg cataactaag 3240gaggccggca gtgtatctct gcgtatgaag caggtggaag aactatatca ttctctgctg 3300gaactgggtg agaagcgtaa aggcatgttg gagaagagtt gcaagaagtt tatgttgttc 3360cgtgaagcga atgaactaca gcaatggatc aatgagaagg aagccgctct gacaagtgag 3420gaggtcggag cagacttgga gcaggttgag gtgctccaga agaagtttga tgacttccag 3480aaggacctga aggccaatga gtcacggttg aaggacatta acaaggtagc tgaagacctg 3540gagtctgaag gtcttatggc agaggaggtg caggctgtgc aacaacagga agtgtatggc 3600atgatgccca gggatgaaac tgattccaag acagcctccc cgtggaagtc tgctcgtctg 3660atggttcaca ccgtggccac ctttaattcc atcaaggagc tgaatgagcg ctggcggtcc 3720ctacagcagc tggccgagga acggagccag ctcttgggca gcgcccatga agtacagagg 3780ttccacagag atgctgatga aaccaaagaa tggattgaag agaagaatca agctctaaac 3840acagacaatt atggacatga tctcgccagt gtccaggccc tgcaacgcaa gcatgagggc 3900ttcgagaggg accttgcggc tctcggtgac aaggtaaact cccttggtga aacagcagag 3960cgcctgatcc agtcccatcc cgagtcagca gaagacctgc aggaaaagtg cacagagtta 4020aaccaggcct ggagcagcct ggggaaacgt gcagatcagc gcaaggcaaa gttgggtgac 4080tcccacgacc tgcagcgctt ccttagcgat ttccgggacc tcatgtcttg gatcaatgga 4140atacgggggt tggtgtcctc agatgagcta gccaaggatg tcaccggagc tgaggcattg 4200ctggagcgac accaggaaca ccggacagaa atcgatgcca gggctggcac tttccaggca 4260tttgagcagt ttggacagca gctgttggct cacggacact atgccagccc tgagatcaag 4320cagaaacttg atattcttga ccaggagcgt gcagacctgg agaaggcctg ggttcagcgc 4380aggatgatgc tggatcagtg ccttgaactg cagctgttcc atcgggactg tgagcaagct 4440gagaactgga tggctgcccg ggaggccttc ttgaataccg aagacaaagg agactcactg 4500gacagcgtag aggctctgat caaaaaacat gaagactttg acaaagcgat taacgtccag 4560gaagagaaga ttgctgctct gcaggccttt gccgaccagc tcatcgctgc cggccattat 4620gccaagggag acatttctag ccggcgcaat gaggtcttgg acaggtggcg acgtctgaaa 4680gcccagatga ttgagaaaag gtcaaagcta ggagaatctc aaaccctcca acagttcagc 4740cgggatgtgg atgagattga ggcttggatc agtgaaaaat tgcaaacagc gagtgatgag 4800tcgtacaagg atcccaccaa catccagctt tccaagctgc tgagcaagca ccagaagcac 4860caggcttttg aagcagagct gcatgccaac gctgaccgga tccgtggggt tatcgacatg 4920ggcaactccc tcattgaacg tggagcctgt gccggcagtg aggatgctgt caaggcccgc 4980ctggctgcct tagctgacca gtggcagttc ttggtgcaaa agtcagcgga aaagagccag 5040aaactgaaag aagccaacaa gcagcagaac ttcaacacag ggatcaagga ctttgacttc 5100tggctgtctg aggtggaggc cctgctggca tccgaagatt atggcaaaga cctggcttct 5160gtgaacaacc tgctgaaaaa gcatcaactg ctggaagcag atatatctgc ccatgaggat 5220cgcctgaagg acctgaacag ccaggcagac agcctgatga ccagcagtgc cttcgacacc 5280tcccaagtaa aggacaagag ggacaccatc aacgggcgct tccagaagat caagagcatg 5340gcggcctccc ggcgagccaa gctgaatgaa tcccatcgcc tgcaccagtt cttccgggac 5400atggatgacg aggagtcctg gatcaaggag aagaagctgc tggtgggctc agaggactac 5460ggccgggacc taactggcgt gcagaacctg aggaagaagc acaagcggct ggaagcagaa 5520ctggctgcgc atgagccggc tattcagggt gtcctggaca ctggcaagaa gctgtccgat 5580gacaacacca tcgggaaaga ggagatccag cagcggctgg cgcagtttgt ggagcactgg 5640aaagagctga agcagctggc agctgcccgg ggtcagcggc tggaagagtc cttggaatat 5700cagcagtttg tagccaatgt ggaagaggaa gaagcctgga tcaatgagaa aatgaccctg 5760gtggccagcg aagattatgg cgacactctt gccgccatcc agggcttact gaagaaacat 5820gaagcttttg agacagactt caccgtccac aaggatcgcg tgaatgatgt ctgcaccaat 5880ggacaagacc tcattaagaa gaacaatcac catgaggaga acatctcttc aaagatgaag 5940ggcctgaacg ggaaagtgtc agacctggag aaagctgcag cccagagaaa ggcgaacgtg 6000gatgagaact cggccttcct tcagttcaac tggaaggcgg acgtggtgga gtcctggatc 6060ggtgaaaagg agaacagctt gaagacagat gattatggcc gagacctgtc ttctgtgcag 6120acgctcctca ccaaacagga aacttttgac gctgggctgc aggccttcca gcaggaaggc 6180attgccaaca tcactgccct caaagatcag cttctcgccg ccaaacacgt tcagtccaag 6240gccatcgagg cccggcacgc ctccctcatg aagaggtgga gccagcttct ggccaactca 6300gccgcccgca agaagaagct tctggaggct cagagtcact tccgcaaggt ggaggacctc 6360ttcctgacct tcgccaaaaa ggcttctgcc ttcaacagct ggtttgaaaa tgcagaggag 6420gacttaacag accccgtgcg ctgcaactcc ttggaagaaa tcaaagcttt gcgcgaggcc 6480cacgacgcct tccgctcctc cctcagctct gcccaggctg acttcaacca gctggccgag 6540ctggaccgcc agatcaagag cttccgcgta gcctccaacc cctacacctg gtttaccatg 6600gaggccctgg aggagacctg gaggaaccta cagaaaatca tcaaggagag ggagctggag 6660ctgcagaagg aacagcggcg gcaggaggag aacgacaagc tgcgccagga gtttgcccag 6720cacgccaacg ccttccacca gtggatccaa gagaccagga catacctcct cgatgggtcc 6780tgtatggtgg aagagtcggg gaccctcgaa tcccagcttg aagctaccaa acgcaagcac 6840caggaaatcc gagccatgag aagtcagctc aaaaagatcg aggacctggg ggccgccatg 6900gaggaggccc tcatcctgga caacaagtac acggagcaca gcaccgtggg cctcgcccag 6960cagtgggacc agctggacca gctgggcatg cgcatgcagc acaacctgga gcagcagatc 7020caggccagga acacaacagg tgtgactgag gaggccctca aagaattcag catgatgttt 7080aaacactttg acaaggacaa gtctggcagg ctgaaccatc aggagttcaa atcttgcctg 7140cgctccctgg gctatgacct gcccatggtg gaggaagggg aacctgaccc tgagttcgag 7200gcaatcctgg acacggtgga tccgaacaga gatggccatg tctccttgca agaatacatg 7260gctttcatga tcagccgcga aactgagaac gtcaagtcca gcgaggagat tgagagcgcc 7320ttccgggccc tcagctcaga gggaaagcct tacgtgacca aggaggagct ctaccagaac 7380ctgacccggg aacaagccga ctactgcgtc tcccacatga agccctacgt ggacggcaag 7440ggccgcgagc tccccaccgc gttcgactac gtggagttca cccgctcgct tttcgtgaac 7500tgagccactc cctgggtcac ccacccctcg ctgcttgccc tgcgtcgcct tgctgcatgt 7560ccgctcctct gtgtgctctc actttccact gtaaccttaa gcctgcttag cttggaataa 7620gacttaggag aaaatggtgc ttcactaacc cgcttccggt ccagtcacaa tc 7672 25 1121 DNA Homo sapiens 25ggaattccct atagagccgg gtgagagagc gagcgcccgt cggcgggtgt cgagggcggg 60ttgcctcgcg ctgacccttc ccgccctcct tctcgtcaca caccaggtcc ccgcggaagc 120cgcggtgtcg gcgccatggc ggagctgacg gctcttgaga gtctcatcga gatgggcttc 180cccaggggac gcgcggagaa ggctctggcc ctcacaggga accagggcat cgaggctgcg 240atggactggc tgatggagca cgaagacgac cccgatgtgg acgagccttt agagactccc 300cttggacata tcctgggacg ggagcccact tcctcagagc aaggcggcct tgaaggatct 360gcttctgctg ccggagaagg caaacccgct ttgagtgaag aggaaagaca ggaacaaact 420aagaggatgt tggagctggt ggcccagaag cagcgggagc gtgaagaaag agaggaacgg 480gaggcattgg aacgggaacg gcagcgcagg agacaagggc aagagttgtc agcagcacga 540cagcggctac aggaagatga gatgcgccgg gctgctgctg aggagaggcg gagggaaaat 600gccgaggagt tagcagccag acaaagagtt agagaaaaga tcgagaggga caaagcagag 660agagccaaga agtatggtgg cagtgtgggc tctcagccac ccccagtggc accagagcca 720ggtcctgttc cctcttctcc cagccaggag cctcccacca agcgggagta tgaccagtgt 780cgcatacagg tcaggctgcc agatgggacc tcactgaccc agacgttccg ggcccgggaa 840cagctggcag ctgtgaggct ctatgtggag ctccaccgtg gggaggaact aggtgggggc 900caggaccctg tgcaattgct cagtggcttc cccagacggg ccttctcaga agctgacatg 960gagcggcctc tgcaggagct gggactcgtg ccttctgctg ttctcattgt ggccaagaaa 1020tgtcccagct gagggccttt gtcccattgt ccctctgtga ccccttcatc tttgataaag 1080cactgacatc tccttcctaa taaatagacc ctgagttctg t 1121 26 3468 DNA Homo sapiens 26aatggcgatg cctaccacct agaactggat tgtgcgctgg ccgccaccgc tgccacctgc 60tcagagtgaa ataatgaagg tggtcaacct gaagcaagcc attttgcaag cctggaagga 120gcgctggagt tactaccaat gggcaatcaa catgaagaaa ttctttccta aaggagccac 180ctgggatatt ctcaacctgg cagatgcgtt actagagcag gccatgattg gaccatcccc 240caatcctctc atcttgtcct acctgaagta tgccattagt tcccagatgg tgtcctactc 300ttctgtcctc acagccatca gtaagtttga tgacttttct cgggacctgt gtgtccaggc 360attgctggac atcatggaca tgttttgtga ccgtctgagc tgtcacggca aagcagagga 420atgcatcgga ctgtgccgag cccttcttag cgccctccac tggctgctgc gctgcacggc 480agcctctgca gagcggctgc gggaggggct ggaggccggc actccagccg ctggggagaa 540gcagcttgcc atgtgccttc agcgcctgga gaaaaccctc agcagcacca agaaccgggc 600cctgctgcac atcgccaaac tagaggaggc ctcttcttgg actgccatcg agcattctct 660cttgaaactt ggagagatcc tgaccaatct cagcaacccg cagctccgga gtcaggccga 720gcagtgtggc accctcatta ggagcatccc cacgatgctg tctgtgcatg cggagcagat 780gcacaagacc ggcttcccca ctgtccacgc cgtgatcctg ctcgagggca ccatgaacct 840gacaggcgag acgcagtccc tggtggagca gctgacgatg gtgaagcgca tgcagcatat 900ccccacccca ctttttgtcc tggagatctg gaaagcttgc ttcgtggggc tcattgagtc 960tcccgagggt acggaggagc tcaagtggac agctttcact ttcctcaaga ttccacaggt 1020tttggtgaag ttgaagaagt actctcatgg agacaaggac ttcactgagg atgtcaactg 1080tgcttttgag ttcctgctga agctcacccc cttgttggac aaagctgacc agcgctgcaa 1140ctgtgactgt acaaacttcc tgctccaaga atgtggcaag caggggcttc tgtctgaggc 1200cagcgtcaac aaccttatgg ctaagcgcaa agcggaccga gagcacgcac cccagcagaa 1260atcgggagag aatgccaaca tccagcccaa catccagctg atcctccggg cggagcccac 1320tgtcacaaac atcctcaaga cgatggatgc agaccactct aagtcaccgg agggactgct 1380gggagtcctg ggccacatgc tgtccgggaa gagtctggac ttgctgctgg ctgccgccgc 1440cgccactgga aagctgaaat ccttcgcccg gaaattcatc aatttgaatg aattcacaac 1500ctatggcagc gaagaaagca ccaaaccggc ctccgtccgg gccctgctgt ttgacatctc 1560cttcctcatg ctgtgccatg tggcccagac ctatggttca gaggtgattc tgtccgagtc 1620gcgcacagga gctgaggtgc ccttcttcga gacctggatg cagacctgca tgcctgagga 1680gggcaagatc ctgaaccctg accacccctg cttccgcccc gactccacca aagtggagtc 1740cctggtggcc ctgctcaaca actcctcgga gatgaagcta gtgcagatga agtggcatga 1800ggcctgtctc agcatctcag ccgccatctt ggaaatcctc aatgcctggg agaatggggt 1860cctggccttc gagtccatcc agaaaatcac tgataacatc aaagggaagg tatgcagtct 1920ggcggtgtgt gctgtggctt ggcttgtggc ccacgtccgg atgctggggc tggatgagcg 1980tgagaagtcg ctgcagatga tccgccagct ggcagggcca ctgtttagtg agaacaccct 2040gcagttctac aatgagaggg tggtgatcat gaactcgatc ctggagcgca tgtgtgccga 2100cgtgctgcag cagacagcca cgcagatcaa gtttccctcc accggggtgg acacaatgcc 2160ctactggaac ctgctgcccc ccaagcggcc catcaaagag gtgctgacgg acatttttgc 2220caaggtgctg gagaagggct gggtggacag ccgctccatc cacatctttg acaccctgct 2280gcacatgggc ggcgtctact ggttctgcaa caacctgatt aaggagctgc tgaaggagac 2340gcggaaggag cacacgctgc gggcagtgga gctgctctac tccatcttct gcctggacat 2400gcagcaagtg accctggtcc tgctgggcca catcctacct ggcctgctca ctgactcctc 2460caagtggcac agcctcatgg accccccggg cactgctctt gccaagctgg ccgtgtggtg 2520tgccctcagt tcctactcct cccacaaggg acaggcgtcc acccgccaga agaagagaca 2580ccgcgaagac attgaggatt atatcagcct cttccccctg gacgatgtgc agccttcgaa 2640gttgatgcga ctgctgagct ctaatgagga cgatgccaac atcctttcga gccccacaga 2700ccgatccatg agcagctccc tctcagcctc tcagctccac acggtcaaca tgcgggaccc 2760tctgaaccga gtcctggcca acctgttcct gctcatctcc tccatcctgg ggtctcgcac 2820cgctggcccc cacacccagt tcgtgcagtg gttcatggag gagtgtgtgg actgcctgga 2880gcagggtggc cgtggcagcg tcctgcagtt catgcccttc accaccgtgt cggaactggt 2940gaaggtgtca gccatgtcca gccccaaggt ggttctggcc atcacggacc tcagcctgcc 3000cctgggccgc caggtggctg ctaaagccat tgctgcactc tgaggggctt ggcatggccg 3060cagtgggggc tggggactgg cgcagcccca ggcgcctcca agggaagcag tgaggaaaga 3120tgaggcatcg tgcctcacat ccgctccaca tggtgcaaga gcctctagcg gcttccagtt 3180ccccgctcct gactcctgac ctccaggatg tctcccggtt tcttctttca aaatttcctc 3240tccatctgct ggcacctgag gagagtgagc agcctggacc acaagcccag tggtcacccc 3300tgtgtgcgcc cgccccagcc caggagtagt cttacctctg aggaactttc tagatgcaaa 3360gtgtgtatgt gtgtgtgtgt gtgtgtgtgt gtgtttgtgt gtattttgta atatgtgagg 3420gaaatctacc ttcgttcatg tataaataaa gctcctcgtg gctccctt 3468 27 2704 DNA Homo sapiens 27gcttagtgta accagcggcg tatatttttt aggcgccttt tcgaaaacct agtagttaat 60attcatttgt ttaaatctta ttttattttt aagctcaaac tgcttaagaa taccttaatt 120ccttaaagtg aaataatttt ttgcaaaggg gtttcctcga tttggagctt tttttttctt 180ccaccgtcat ttctaactct taaaaccaac tcagttccat catggtgatg ttcaagaaga 240tcaagtcttt tgaggtggtc tttaacgacc ctgaaaaggt gtacggcagt ggcgagaggg 300tggctggccg ggtgatagtg gaggtgtgtg aagttactcg tgtcaaagcc gttaggatcc 360tggcttgcgg agtggctaaa gtgctttgga tgcagggatc ccagcagtgc aaacagactt 420cggagtacct gcgctatgaa gacacgcttc ttctggaaga ccagccaaca ggtgagaatg 480agatggtgat catgagacct ggaaacaaat atgagtacaa gttcggcttt gagcttcctc 540aggggcctct gggaacatcc ttcaaaggaa aatatgggtg tgtagactac tgggtgaagg 600cttttcttga ccgcccgagc cagccaactc aagagacaaa gaaaaacttt gaagtagtgg 660atctggtgga tgtcaatacc cctgatttaa tggcacctgt gtctgctaaa aaagaaaaga 720aagtttcctg catgttcatt cctgatgggc gggtgtctgt ctctgctcga attgacagaa 780aaggattctg tgaaggtgat gagatttcca tccatgctga ctttgagaat acatgttccc 840gaattgtggt ccccaaagct gccattgtgg cccgccacac ttaccttgcc aatggccaga 900ccaaggtgct gactcagaag ttgtcatcag tcagaggcaa tcatattatc tcagggacat 960gcgcatcatg gcgtggcaag agccttcggg ttcagaagat caggccttct atcctgggct 1020gcaacatcct tcgagttgaa tattccttac tgatctatgt tagcgttcct ggatccaaga 1080aggtcatcct tgacctgccc ctggtaattg gcagcagatc aggtctaagc agcagaacat 1140ccagcatggc cagccgaacc agctctgaga tgagttgggt agatctgaac atccctgata 1200ccccagaagc tcctccctgc tatatggatg tcattcctga agatcaccga ttggagagcc 1260caacaactcc tctgctagat gacatggatg gctctcaaga cagccctatc tttatgtatg 1320cccctgagtt caagttcatg ccaccaccga cttatactga ggtggatccc tgcatcctca 1380acaacaatgt gcagtgagca tgtggaagaa aagaagcagc tttacctact tgtttctttt 1440tgtctctctt cctggacact cactttttca gagactcaac agtctcgtca atggagtgtg 1500ggtccacctt agcctctgac ttcctaatgt aggaggtggt cagcaggcaa tctcctgggc 1560cttaaaggat gcggactcat cctcagccag cgcccatgtt gtgatacagg ggtgtttgtt 1620ggatgggttt aaaaataact agaaaaactc aggcccatcc attttctcag atctccttga 1680aaattgaggc cttttcgata gtttcgggtc aggtaaaaat ggcctcctgg cgtaagcttt 1740tcaaggtttt ttggaggctt tttgtaaatt gtgataggaa ctttggacct tgaacttacg 1800tatcatgtgg agaagagcca atttaacaaa ctaggaagat gaaaagggaa attgtggcca 1860aaactttggg aaaaggaggt tcttaaaatc agtgtttccc ctttgtgcac ttgtagaaaa 1920aaaagaaaaa ccttctagag ctgatttgat ggacaatgga gagagctttc cctgtgatta 1980taaaaaagga agctagctgc tctacggtca tctttgctta gagtatactt taacctggct 2040tttaaagcag tagtaactgc cccaccaaag gtcttaaaag ccatttttgg agcctattgc 2100actgtgttct cctactgcaa atattttcat atgggaggat ggttttctct tcatgtaagt 2160ccttggaatt gattctaagg tgatgttctt agcactttaa ttcctgtcaa attttttgtt 2220ctccccttct gccatcttaa atgtaagctg aaactggtct actgtgtctc tagggttaag 2280ccaaaagaca aaaaaaattt tactactttt gagattgccc caatgtacag aattatataa 2340ttctaacgct taaatcatgt gaaagggttg ctgctgtcag ccttgcccac tgtgacttca 2400aacccaagga ggaactcttg atcaagatgc ccaaccctgt gatcagaacc tccaaatact 2460gccatgagaa actagagggc aggtgttcat aaaagccctt tgaaccccct tcctgccctg 2520tgttaggaga tagggatatt ggcccctcac tgcagctgcc agcacttggt cagtcactct 2580cagccatagc actttgttca ctgtcctgtg tcagagcact gagctccacc cttttctgag 2640agttattaca gccagaaagt gtgggctgaa gatggttggt ttcatgtggg ggtattatgt 2700accc 2704 28 413 DNA Homo sapiens misc_feature (1)...(413) n = A,T,C or G 28acaggcacac tgcaccagcg ttcaatagct gaacttgtgc ccaagtgcca tccgctagca 60gctttgagca gatggaggct gtgaacatcg cacagacacc tgcagagctc tacaatgcca 120ttctggtgga cacacccctg gcggcttttt tccaggactg catctcagag caggaccttg 180atgagatgaa catcgagata atccgaaata cgctttacaa ggcctacttg gaagtccttc 240tacaagttct gtactctgtt gggtgggacc acagctgatg ccatgtgtcc tatcctagag 300tttgaagcag accgccgcgc tttcatcatc accatcaact ctttccggca cagagctgtc 360caaggaggac cgtgccaagc tcttcccgca ctgtggccgg ctctancctg agg 413 29 2602 DNA Homo sapiens 29gccgtgtcgc caccatggct ccgcaccgcc ccgcgcccgc gctgctttgc gcgctgtccc 60tggcgctgtg cgcgctgtcg ctgcccgtcc gcgcggccac tgcgtcgcgg ggggcgtccc 120aggcgggggc gccccagggg cgggtgcccg aggcgcggcc caacagcatg gtggtggaac 180accccgagtt cctcaaggca gggaaggagc ctggcctgca gatctggcgt gtggagaagt 240tcgatctggt gcccgtgccc accaaccttt atggagactt cttcacgggc gacgcctacg 300tcatcctgaa gacagtgcag ctgaggaacg gaaatctgca gtatgacctc cactactggc 360tgggcaatga gtgcagccag gatgagagcg gggcggccgc catctttacc gtgcagctgg 420atgactacct gaacggccgg gccgtgcagc accgtgaggt ccagggcttc gagtcggcca 480ccttcctagg ctacttcaag tctggcctga agtacaagaa aggaggtgtg gcatcaggat 540tcaagcacgt ggtacccaac gaggtggtgg tgcagagact cttccaggtc aaagggcggc 600gtgtggtccg tgccaccgag gtacctgtgt cctgggagag cttcaacaat ggcgactgct 660tcatcctgga cctgggcaac aacatccacc agtggtgtgg ttccaacagc aatcggtatg 720aaagactgaa ggccacacag gtgtccaagg gcatccggga caacgagcgg agtggccggg 780cccgagtgca cgtgtctgag gagggcactg agcccgaggc gatgctccag gtgctgggcc 840ccaagccggc tctgcctgca ggtaccgagg acaccgccaa ggaggatgcg gccaaccgca 900agctggccaa gctctacaag gtctccaatg gtgcagggac catgtccgtc tccctcgtgg 960ctgatgagaa ccccttcgcc cagggggccc tgaagtcaga ggactgcttc atcctggacc 1020acggcaaaga tgggaaaatc tttgtctgga aaggcaagca ggcaaacacg gaggagagga 1080aggctgccct caaaacagcc tctgacttca tcaccaagat ggactacccc aagcagactc 1140aggtctcggt ccttcctgag ggcggtgaga ccccactgtt caagcagttc ttcaagaact 1200ggcgggaccc agaccagaca gatggcctgg gcttgtccta cctttccagc catatcgcca 1260acgtggagcg ggtgcccttc gacgccgcca ccctgcacac ctccactgcc atggccgccc 1320agcacggcat ggatgacgat ggcacaggcc agaaacagat ctggagaatc gaaggttcca 1380acaaggtgcc cgtggaccct gccacatatg gacagttcta tggaggcgac agctacatca 1440ttctgtacaa ctaccgccat ggtggccgcc aggggcagat aatctataac tggcagggtg 1500cccagtctac ccaggatgag gtcgctgcat ctgccatcct gactgctcag ctggatgagg 1560agctgggagg tacccctgtc cagagccgtg tggtccaagg caaggagccc gcccacctca 1620tgagcctgtt tggtgggaag cccatgatca tctacaaggg cggcacctcc cgcgagggcg 1680ggcagacagc ccctgccagc acccgcctct tccaggtccg cgccaacagc gctggagcca 1740cccgggctgt tgaggtattg cctaaggctg gtgcactgaa ctccaacgat gcctttgttc 1800tgaaaacccc ctcagccgcc tacctgtggg tgggtacagg agccagcgag gcagagaaga 1860cgggggccca ggagctgctc agggtgctgc gggcccaacc tgtgcaggtg gcagaaggca 1920gcgagccaga tggcttctgg gaggccctgg gcgggaaggc tgcctaccgc acatccccac 1980ggctgaagga caagaagatg gatgcccatc ctcctcgcct ctttgcctgc tccaacaaga 2040ttggacgttt tgtgatcgaa gaggttcctg gtgagctcat gcaggaagac ctggcaacgg 2100atgacgtcat gcttctggac acctgggacc aggtctttgt ctgggttgga aaggattctc 2160aagaagaaga aaagacagaa gccttgactt ctgctaagcg gtacatcgag acggacccag 2220ccaatcggga tcggcggacg cccatcaccg tggtgaagca aggctttgag cctccctcct 2280ttgtgggctg gttccttggc tgggatgatg attactggtc tgtggacccc ttggacaggg 2340ccatggctga gctggctgcc tgaggagggg cagggcccac ccatgtcacc ggtcagtgcc 2400ttttggaact gtccttccct caaagaggcc ttagagcgag cagagcagct ctgctatgag 2460tgtgtgtgtg tgtgtgtgtt gtttcttttt ttttttttta cagtatccaa aaatagccct 2520gcaaaaattc agagtccttg caaaattgtc taaaatgtca gtgtttggga aattaaatcc 2580aataaaaaca ttttgaagtg tg 2602 30 14770 DNA Homo sapiens 30gggacaccat catttgggtt tttaaaagct tcagcttctc cagcatcttt gcattgtgaa 60tatcttcctg cttctagtca aagctttctc tctagtgatt ggaatgctgc tgtaagccta 120ttagaggtgc ctgaggatat caccttttac aaggaagccg tgtgtgcttg agaggatctt 180tttaaatgca ttatggctca tgcagcctca caattaaaga aaaacaggga tttagaaatc 240aatgctgaag aagagcctga gaaaaaaagg aaacaccgca aacggtcccg ggatcggaag 300aaaaagtctg atgccaatgc aagttactta agagcagctc gagctggaca ccttgaaaag 360gccctcgact acataaaaaa tggagttgac atcaacattt gcaatcagaa tgggttgaac 420gctctccacc ttgcttccaa agaaggccat gtagaggttg tttctgagct gctgcagaga 480gaagccaatg tggatgcagc tacaaagaaa ggaaacacag cattgcacat cgcatctttg 540gctgggcaag cagaggtggt aaaagtcttg gttacaaatg gagccaatgt caatgcacaa 600tctcagaatg gtttcacgcc attgtatatg gcagcccagg aaaatcacct ggaagttgtc 660aagtttcttc ttgacaatgg tgcaagccag agcctagcca cagaggatgg cttcacacca 720ttggcagtgg ctttgcaaca aggtcacgac caagtcgttt cgctcctgct agagaatgac 780accaaaggaa aagtgcgtct cccagctctt catatcgcgg cccgcaaaga cgacacaaaa 840gccgccgccc tgctgctgca gaatgacaac aatgcagatg tggaatcaaa gagtggcttc 900actccgctcc acatagctgc tcactatgga aatatcaatg tagccacgtt gctgttaaac 960cgagcggctg ctgtggattt caccgcaagg aatgacatca ctcctttaca tgttgcatca 1020aaaagaggaa atgcaaatat ggtaaaacta ttgctcgatc gaggagctaa aatcgatgcc 1080aaaaccaggg atggtctgac accactgcac tgtggagcaa ggagtggcca cgagcaggtg 1140gtagaaatgt tgcttgatcg agctgccccc attctttcaa aaaccaagaa tggattatct 1200ccattgcaca tggccacaca aggggatcat ttaaactgcg tccagcttct cctccagcat 1260aatgtacccg tggatgatgt caccaatgac tacctgactg ccctacacgt ggctgcccac 1320tgtggccatt acaaagttgc caaggttctc ttggataaga aagctaaccc caatgccaaa 1380gccctgaatg gctttacccc tcttcatatc gcctgcaaga agaatcgaat taaagtaatg 1440gaactccttc tgaaacacgg tgcatccatc caagctgtaa ccgagtcggg ccttacccca 1500atccatgttg ctgccttcat ggggcatgta aatattgtat cacaactaat gcatcatgga 1560gcctcaccaa acaccaccaa tgtgagagga gaaacagcac tgcacatggc agctcgctcc 1620ggccaagctg aagttgtgcg gtatctggta caagacggag ctcaggtaga agctaaagct 1680aaggatgacc aaacaccact ccacatttca gcccgactgg ggaaagcaga catagtacaa 1740cagctgttgc agcaaggggc atctccaaat gcagccacaa cttctgggta caccccactt 1800cacctttccg cccgagaggg gcatgaggat gtggccgcgt tccttttgga tcatggagcg 1860tctttatcta taacaacaaa gaaaggattt actcctcttc atgtggcagc aaaatatgga 1920aagcttgaag tcgccaatct cctgctacag aaaagtgcat ctccagatgc tgctgggaag 1980agcgggctaa caccactgca tgtagctgca cattacgata atcagaaagt ggcccttctg 2040cttttggacc aaggagcctc acctcacgca gccgcaaaga atggttatac gccactgcac 2100atcgctgcca aaaagaacca gatggacata gcgacaactc tgctggaata tggtgctgat 2160gccaacgcag ttacccggca aggaattgct tccgtccatc tcgcagctca ggaagggcac 2220gtggacatgg tgtcgctgct cctcggtaga aatgcgaatg tgaacctgag caataagagc 2280ggcctgaccc cactccattt ggctgctcaa gaagatcgag tgaatgtggc agaagtcctc 2340gtaaaccaag gggctcatgt ggacgcccag acaaagatgg gatacacacc actgcatgtg 2400ggctgccact atggaaatat caagattgtt aatttcctgc tccagcattc tgcaaaagtt 2460aatgccaaaa caaagaatgg gtatacgcca ttacatcaag cagcacagca ggggcatacg 2520catataataa atgtcttact tcagaacaac gcctccccca atgaactcac tgtgaatggg 2580aatactgccc ttggcattgc ccggcgcctc ggctacatct cagtagtgga caccctgaag 2640atagtgaccg aagaaaccat gaccacaact actgtcacag agaagcacaa aatgaatgtt 2700ccagaaacga tgaatgaagt tcttgatatg tctgatgatg aagttcgtaa agccaatgcc 2760cctgaaatgc tcagtgatgg cgaatatatc tcagatgttg aagaaggtga agatgcaatg 2820accggggaca cagacaaata tcttgggcca caggacctta aggaattggg tgatgattcc 2880ctgcctgcag agggttacat gggctttagt ctcggagcgc gttctgccag cctccgctcc 2940ttcagttcgg ataggtctta caccttgaac agaagctcct atgcacggga cagcatgatg 3000attgaagaac tccttgtgcc atccaaagag cagcatctaa cattcacaag ggaatttgat 3060tcagattctc ttagacatta cagctgggct gcagacacct tagacaatgt caatcttgtt 3120tcaagcccca ttcattctgg gtttctggtt agctttatgg tggacgcgag agggggctcc 3180atgagaggaa gccgtcatca cgggatgaga atcatcattc ctccacgcaa gtgtacggcc 3240cccactcgaa tcacctgccg tttggtaaag agacataaac tggccaaccc acccccacat 3300ggtgaaagga gagggattag cagtaggctg gtagaaatgg gtcctgcagg ggcacaattt 3360ttaggccctg tcatagtgga aatccctcac tttgggtcca tgagaggaaa agagagagaa 3420ctcattgttc ttcgaagtga aaatggtgaa acttggaagg agcatcagtt tgacagcaaa 3480aatgaagatt taaccgagtt acttaatggc atggatgaag aacttgatag cccagaagag 3540ttagggaaaa agcgtatctg caggattatc acgaaagatt tcccccagta ttttgcagtg 3600gtttcccgga ttaagcagga aagcaaccag attggtcctg aaggtggaat tctgagcagc 3660accacagtgc cccttgttca agcatctttc ccagagggtg ccctaactaa aagaattcga 3720gtgggcctcc aggcccagcc tgttccagat gaaattgtga aaaagatcct tggaaacaaa 3780gcaactttta gcccaattgt cactgtggaa ccaagaagac ggaaattcca taaaccaatc 3840acaatgacca ttccggtgcc cccgccctca ggagaaggtg tatccaatgg atacaaaggg 3900gacactacac ccaatctgcg tcttctctgt agcattacag ggggcacttc gcctgctcag 3960tgggaagaca tcacaggaac aactcctttg acgtttataa aagattgtgt ctcctttaca 4020accaatgttt cagccagatt ttggcttgca gactgccatc aagttttaga aactgtgggg 4080ttagccacgc aactgtacag agaattgata tgtgttccat atatggccaa gtttgttgtt 4140tttgccaaaa tgaatgatcc cgtagaatct tccttgcgat gtttctgcat gacagatgac 4200aaagtggaca aaactttaga gcaacaagag aattttgagg aagtcgcaag aagcaaagat 4260attgaggttc tggaaggaaa acctatttat gttgattgtt atggaaattt ggccccactt 4320accaaaggag gacagcaact tgtttttaac ttttattctt tcaaagaaaa tagactgcca 4380ttttccatca agattagaga caccagccaa gagccctgtg gtcgtctgtc ttttctgaaa 4440gaacgaaaga caacaaaagg actgcctcaa acagcggttt gcaacttaaa tatcactctg 4500ccagcacata aaaaggagac agagtcagat caagatgatg agattgagaa aacagataga 4560cgacagagct tcgcatcctt agctttacgt aagcgctaca gctacttgac tgagcctgga 4620atgattgaac ggagtacagg agcaacaaga tccctcccca ccacttactc atacaagcca 4680ttcttttcta caagaccata ccagtcctgg acaacagctc cgattacagt gcctgggcca 4740gccaagtcag gcttcacttc cttatcaagt tcttcctcta atacgccatc agcttctccg 4800ttaaaatcaa tatggtctgt ttcgacacct tctccaatca aatccacatt aggcgcgtca 4860actacatctt cagttaaatc cattagtgac gtggcatctc caattagatc cttacggaca 4920atgtcttcgc cgataaaaac tgtggtgtca caatctccat acaatatcca ggtttcctct 4980ggtaccctgg ctagagctcc agcagtcacg gaagctacgc ccttaaaagg gctggcatcc 5040aattctacgt tttcctctcg aacctctcca gtgactacag cagggtctct tttggagagg 5100tcatcaatta ctatgacacc ccctgcctcc cccaaatcaa acattaatat gtattcctca 5160agtttgccat ttaagtcaat tattacatca gcagcaccgc taatatcttc acctttaaag 5220tcagtggtgt ctccagttaa atcacgagtt gatgtcattt catcagccaa aattacaatg 5280gcatcttctc tctcatcacc tgtgaagcag atgcctggac atgcagaggt agcattagtc 5340aatggatcta tttcccctct aaaatatgca tcatcctcaa ctttaattaa tggatgcaaa 5400gccactgcca cgttacagga aaaaatttct tctgctacaa actctgtgag ctctgtggtc 5460agtgcagcca ctgacacagt tgagaaagtg ttttctacca cgactgcaat gccattttcc 5520ccactcaggt catatgtttc tgcagcacca tcagcttttc agtctctaag aactccttcc 5580gcaagtgcac tctatacatc ccttgggtcg tcaatatctg caactacctc atctgtaact 5640tcatcaatta taacagtgcc agtatactct gtagtcaatg ttttgccaga accagcatta 5700aagaaacttc cagactctaa ttcatttaca aaatcagcag cagccttgct gtcacccatt 5760aaaacattga ctacggagac acatcctcag cctcacttca gtcgaacttc atctccagtt 5820aagtcatctt tgttccttgc accctctgcc cttaagttgt ctacaccatc ttctttatct 5880tccagtcagg agatactaaa agatgtagct gaaatgaaag aggacctaat gcggatgacc 5940gcaatactac agacagatgt gcctgaggag aagccattcc aacctgaact cccaaaggaa 6000gggagaatag atgatgaaga acctttcaaa attgtagaga aagtaaagga agacttagtg 6060aaagttagtg aaatccttaa aaaggatgta tgtgtagata ataaaggatc acccaaatca 6120ccaaagagtg acaaaggaca ctctcctgaa gatgactgga tagaatttag ttcggaagaa 6180atccgggaag ccagacaaca agctgctgcg agccagtctc catctctgcc agagagagtg 6240caagtaaaag caaaagccgc ctccgaaaag gattataact tgaccaaagt tattgattac 6300ctaacaaatg atattgggag tagttcactg acaaacttaa aatacaagtt tgaggatgca 6360aagaaggatg gtgagggagg acagaaaaga gttttaaaac cagcaattgc tttgcaggaa 6420cacaaactca aaatgcctcc agcctccatg aggacttcca cctctgagaa agaattgtgt 6480aaaatggctg attccttttt tggaacagat actattttag agtctcctga tgacttttct 6540caacacgacc aagataaaag tcccttgtct gacagtggct ttgaaacaag aagtgaaaag 6600acaccttcag ccccacaaag cgctgaaacg actggtccta aaccactttt tcatgaagtt 6660cccatccctc ctgttattac agaaacaaga actgaagtgg ttcatgttat caggagctat 6720gatccctcag ctggggatgt tccccagacc caaccagagg agcctgtgtc acctaaacct 6780tcacctactt ttatggaatt ggaaccaaag cccaccacct ctagtattaa agaaaaggtt 6840aaagcatttc aaatgaaagc cagtagtgaa gaagatgacc acaatcgggt tttaagcaaa 6900ggcatgcgtg ttaaagaaga gactcacata accacaacca ccagaatggt ttatcattct 6960ccaccaggcg gtgaaggtgc atctgaaaga attgaagaaa ccatgtcagt ccatgacatc 7020atgaaggcct ttcagtccgg gcgggatcct tccaaagaac tggcaggtct gtttgaacat 7080aagtcggcag tgtctccaga tgttcacaag tctgctgctg aaacctcagc ccagcatgca 7140gagaaggaca accaaatgaa acccaaactg gagcgtataa tagaagtcca catcgaaaaa 7200ggtaaccaag ctgagcccac tgaagtcatt attagagaaa ccaaaaagca tccagaaaaa 7260gaaatgtatg tatatcagaa agacttatcc cggggagata ttaacctaaa agattttctg 7320ccagaaaaac acgatgcttt tccttgttca gaggaacagg gtcagcaaga agaagaagaa 7380cttactgctg aagagtcatt gccttcttat ctggagtctt ccagagtaaa cactcctgtg 7440tcccaagaag aagatagccg ccctagttct gctcaactca tatctgatga ctcttataaa 7500acattgaagc ttttgagtca acactcaata gaataccatg acgatgagtt gtcagaacta 7560agaggggagt cttacaggtt tgctgagaaa atgcttctgt cagaaaagct agatgtgtct 7620cattctgata ctgaggaatc ggttacagac catgcaggac cccctagctc agagttacag 7680gggtctgata agcggtccag agaaaaaata gccactgccc ccaaaaaaga aattctctcc 7740aaaatctata aagatgtttc tgaaaatggt gtaggtaaag tgtctaaaga tgagcatttt 7800gataaagtga cagtgttgca ctattctggc aatgttagta gtccaaaaca tgccatgtgg 7860atgcgcttta ctgaggacag attagacaga ggtagagaga agttgatata tgaagatagg 7920gtggacagga ctgtgaagga ggctgaagaa aaactgactg aagtgtcaca gttttttcgt 7980gacaaaactg aaaagctaaa tgatgaactg cagtccccag agaaaaaggc acgccctaaa 8040aatggcaaag aatattcttc tcaaagccct accagtagca gccctgagaa agtgctactg 8100acagaactgc tggcatccaa tgatgagtgg gttaaggcaa gacagcatgg ccctgatgga 8160caaggcttcc ccaaggccga ggagaaggca cccagtctgc ccagcagccc agagaagatg 8220gttctctccc aacagactga ggacagcaag tccacagtgg aagccaaagg aagtatttca 8280cagagcaaag caccagatgg gccccagtct ggattccagc tcaaacaatc taaactcagt 8340tccattagat taaaatttga acaaggcaca cacgcaaaaa gtaaggacat gtctcaagaa 8400gacagaaagt cagatggcca gtccagaatc ccagttaaaa aaatacagga gagcaagcta 8460cccgtctacc aagtttttgc tagagaaaaa cagcagaagg ccatagacct cccagatgaa 8520agtgtatctg tgcaaaaaga ttttatggta ttaaaaacca aagatgagca tgcccaaagc 8580aacgaaattg ttgtaaatga ttctggctct gataatgtga aaaaacagag aactgaaatg 8640tcaagtaaag caatgcctga ctctttttct gagcagcagg ctaaagactt ggcatgtcat 8700ataacctcag atttagcaac taggggacca tgggacaaaa aggtctttag aacatgggag 8760agttcgggag ccactaacaa taagtctcag aaagaaaaac tttcgcatgt acttgttcat 8820gatgtaagag agaatcacat tggtcaccct gagagtaaaa gtgttgatca aaagaatgaa 8880tttatgtctg tgactgagag agaacgcaaa ttgttaacaa acggctctct ctcagaaatt 8940aaagaaatga ctgtaaaatc tccctccaaa aaagtcttat atagggaata tgttgtgaaa 9000gaaggggacc atccaggcgg attgcttgat cagccttcca ggaggagcga gagctcagca 9060gtgtcacaca ttcccgtcag agttgctgat gagaggagaa tgctgtcttc taatattccc 9120gatggttttt gtgaacagtc ggcatttcca aaacatgaac tatcacaaaa attgtcccag 9180tcaagcatga gtaaagagac agttgagaca cagcacttta attctataga agatgaaaaa 9240gttacctatt cagaaatcag caaagtttcc aaacaccaga gttatgtagg tttatgccca 9300cctctcgagg aaaccgaaac ctcccccacc aaatctcctg attctttaga gtttagccca 9360ggaaaggaat ctccctctag tgatgtattc gaccacagtc ccattgatgg attggaaaaa 9420ctcgcaccac tagcccagac agagggaggg aaagagataa aaactttacc cgtttatgtc 9480agttttgtac aagtggggaa gcaatatgaa aaggagatac aacaaggagg tgtaaaaaaa 9540atcataagtc aggaatgtaa gacagtacaa gaaaccaggg ggacctttta tacaactaga 9600cagcaaaagc aacctccttc tccccaaggt agtccagaag atgatactct agagcaagta 9660tcctttctag acagctctgg gaaaagccct ttaaccccag aaacacccag ttcagaggaa 9720gtgagttatg aatttacatc taagacacct gactcgctca tagcttatat accaggcaaa 9780cccagcccaa ttcccgaggt ttctgaggag tcagaggagg aggaacaggc caagtcaacc 9840tcccttaagc agactacagt ggaggaaaca gcagttgagc gtgaaatgcc taatgacgtg 9900agcaaagact ctaaccaaag acccaaaaat aacagagttg cctatattga atttccccct 9960cctccaccac tggatgcgga ccagattgag tcagataaga agcatcatta tctcccagaa 10020aaagaggttg acatgattga agtcaatctg caagatgagc atgacaagta ccagctggct 10080gaacctgtca ttagagtgca gccaccttca ccagttcctc ccggggcaga cgtcagtgat 10140tcaagcgatg acgaatctat ttatcagcca gtcccagtta aaaaatatac cttcaaatta 10200aaggaagtgg acgatgaaca aaaagaaaaa cccaaagctt ctgctgaaaa ggcttccaac 10260cagaaagaac tggaaagtaa tggatctgga aaagataatg aatttggcct tggccttgat 10320tcacctcaga atgaaattgc ccagaatggg aacaacgacc agtccatcac agagtgttcc 10380attgccacca cagcagagtt ttctcatgac acggatgcca cagagatcga ctctctggat 10440ggctatgacc tgcaagatga agatgatggc ttgacagaga gtgattctaa actcccaatt 10500caagccatgg aaattaagaa agatatctgg aacacagagg gcattctgaa gccagctgac 10560cgctctttta gccaaagtaa acttgaagtt atcgaggagg agggaaaggt gggaccagat 10620gaggacaagc caccttctaa aagttcttca tctgaaaaga ctcctgataa gactgatcag 10680aagtcagggg cccagttctt cacactggaa ggcagacatc ctgacagatc agtgtttcct 10740gatacttact tcagttacaa agtagatgaa gaatttgcca ctccttttaa aacagtagct 10800accaaaggtc tagattttga cccttggtct aataaccgag gggatgatga agtttttgac 10860agtaaatcac gggaagatga aactaagcca tttgggctgg cggtagaaga ccgctctcca 10920gcaacaaccc ctgatacaac gccagccaga acgccaactg atgaaagtac cccaactagt 10980gagcctaacc ccttcccatt tcatgaagga aaaatgtttg agatgactcg cagtggtgca 11040attgacatga gcaagaggga ttttgttgaa gagaggctcc aatttttcca gattggtgag 11100catacttctg aagggaagtc aggggaccag ggggaagggg ataaaagtat ggtcactgcc 11160acaccacagc cacagtcagg ggacaccact gtagaaacca atctagagag aaatgtagag 11220acacctacag tggaacctaa ccccagcatc ccgaccagcg gagagtgtca ggaaggcaca 11280tccagtagtg gctccctgga gaaatcagca gcagccacta acacctctaa agttgacccc 11340aagttgcgca cgcctataaa aatgggaatt tctgcatcca ccatgaccat gaagaaagaa 11400ggccctggag aaataacaga taagatagaa gcggtgatga ccagttgtca gggattagaa 11460aatgaaacta taacaatgat ttcaaataca gccaatagcc agatgggcgt taggccccat 11520gaaaaacatg attttcaaaa agataacttt aataacaaca acaatttgga ttcttccact 11580atacagacag ataacattat gagtaatata gttctgacag aacattctgc acccacttgt 11640accacagaga aagataaccc agtgaaagtc tcatcaggaa aaaagacagg ggtactacaa 11700ggacactgtg taagagataa gcagaaagtt cttggagaac agcaaaaaac aaaggaattg 11760atagggatta ggcaaaaatc caaacttccc ataaaggcca cttcaccaaa agataccttc 11820ccaccgaacc atatgtcaaa cactaaagca agtaaaatga agcaggttag tcaatccgag 11880aaaaccaaag cccttactac ttcttcatgt gtagatgtaa agtccagaat tccagtgaaa 11940aacacaccca gggataacat aattgcagtt agaaaagcat gtgccacaca aaagcaaggg 12000cagccagaga aaggcaaggc caaacagctt ccatccaagt tgccagtaaa ggtaagatcc 12060acctgtgtca ctaccaccac caccactgcc accaccacca ccactaccac cactaccacc 12120accaccagct gcacagttaa agttaggaaa agtcagctca aggaagtatg taaacattcc 12180attgaatatt ttaagggaat tagtggtgag accttaaagc ttgtggaccg cctctctgaa 12240gaagaaaaaa agatgcagtc cgagttgtcc gatgaggaag aaagtacctc aagaaacacg 12300tcgttgtccg agacttcccg gggtggccag ccttcggtta caacgaagtc tgctagagat 12360aagaaaacag aggcagcacc tttaaaatca aagagtgaaa aggccggcag tgagaaaagg 12420agcagtagaa ggactggtcc acagagtcca tgtgaacgga cagatatcag gatggcaata 12480gtagccgatc acctgggact tagttggaca gaactggcaa gggaactgaa tttttcagtg 12540gatgaaatca atcaaatacg tgtggaaaat ccaaattctt taatttctca gagcttcatg 12600ttattaaaaa aatgggttac cagagacgga aaaaatgcca caactgatgc cttaacttcg 12660gtcttgacaa aaattaatcg aatagatata gtgacactgc tagaaggacc aatatttgat 12720tatggaaata tttcaggcac cagaagtttt gcagatgaga acaatgtttt ccatgaccct 12780gttgatggtt ggcagaatga gacatcaagt ggaaacctag agtcctgcgc tcaagctcga 12840agagtaactg gtgggttact agatcgactg gatgacagcc ctgaccagtg tagagattcc 12900attacctcat atctcaaagg agaagctggc aaatttgaag caaatggaag ccatacagaa 12960atcactccag aagcaaagac aaaatcttac tttccagaat cccaaaatga tgtaggaaaa 13020cagagtacca aggaaactct gaaaccaaaa atacatggat ctggtcatgt tgaagaacca 13080gcatcaccac tagcagcata tcagaaatct ctagaagaaa ccagcaagct tataatagaa 13140gagactaaac cctgtgtgcc tgtcagtatg aaaaagatga gtaggacttc tccagcagat 13200ggcaagccaa ggcttagcct ccatgaagaa gaggggtcca gtgggtctga gcaaaagcag 13260ggagaaggtt ttaaggtgaa aacgaagaaa gaaatccggc atgtggaaaa gaagagccac 13320tcgtaacagc gaacggtcag tcaaggatca taagttttta ctgccagtat tgagaaattc 13380gtggaagaaa tgtcagcagg aagtaaaaat tcaccgagaa gtgtgtgtgt gttcgctgct 13440tccacacatt aatggcatga ttttttttat gcaaaaagaa aagaaaagaa aaccacccac 13500attttaattt agcatgagcc aatttacaga gcatggaaat cactttcatt tccggattgg 13560cgcgtgtgca attagcaatg cagtgtatat acaagaagcc atgctgttaa cagtttatct 13620caagtaattt ggtgtcattt acaaaaggaa gaaattcttg ccatcagaag ggacagaagg 13680agatggaatg atcaaatcac agagaaacac taaaattact aaatctacaa cagctcgcct 13740tatttttctt ggacccaaac tgtcagggta taaacactat ttgtttcttt tttaaaacat 13800cgatagtttt gctgtaaata ataacactgt ataaattcta acagaaaaat agaataaaat 13860gttgataagg cactgcctct tagaacacaa acagaatatt gcaaatgcat ttaacaaata 13920ggggtctcaa gtgacttcac cctagaagag gagggaggga ttctgggtgg gggtgactct 13980tcactgattc ttgtatatta gcaattataa tgtttgtata tgcaaaactg ctagcttgat 14040tttaaaaaaa aacaaatctt taaaatctgc tgcaaattta aataattccc aaaatgagga 14100attctgtagt tctgtgaaaa atttttttct tcagaatact aatattttga tgcatgtgta 14160tcaccttatt ttgattaaat cttttccaat tttgcaaaca ctacagtata ctgcaacaca 14220aaagatttta tctgtaaaca caaagccctt catctaatat ttgttgctat tgccaatttt 14280tcaatgaaat gacctaaaaa caacaaaaaa aaataaccta tacggtagtt gctttagggg 14340gtggggggat gctatctgtt agtgcttaaa agggggtaaa tgcttgccgc tttagaggtg 14400gatggtgctc ataaaaggcc ccagtcgggg gtatttaaaa aggactgaac agaaatcctt 14460agctagtaga atggcagcac gctgtaaaat tattactgta ttgtgtactg gctataagat 14520gtagacacct ttcagtaagc caatcatttg taaccattct agcagtgtca tattaggtta 14580ataaggctgc tgtgttttaa agggcatttt tatttgggtt ttggtgaaat tctttaattt 14640gttgattata ttcacataaa atcagcattc attgacacat agctctaatg acatatgtat 14700gaaaaaccat acactggatg acctagtcga ttatttaagc ataaaataaa ttgtgttaaa 14760ctcttcacct 14770 31 1194 DNA Homo sapiens 31ttaattcggc ggccgcggat ccgagccgga cgggcactgg gcgactctgt gcttcgctga 60ggaaaaataa ctaaacatgg gcaaaggaga tcctaagaag ccgagacgga aaatgtcatc 120atatgcattt tttgtgcaaa cttgtcggga ggagcataag aagaagcacc cagatgcttc 180agtcaacttc tcagagtttt ctaagaagtg ctcagagagg tggaagacca tgtctgctaa 240agagaaagga aaatttgaag atatggcaaa agcggacaag gcccgttatg aaagagaaat 300gaaaacctat atccctccca aaggggagac aaaaaagaag ttcaaggatc ccaatgcacc 360caagaggcct ccttcggcct tcttcctctt ctgctctgag tatcgcccaa aaatcaaagg 420agaacatcct ggcctgtcca ttggtgatgt tgcgaagaaa ctgggagaga tgtggaataa 480cactgctgca gatgacaagc agccttatga aaagaaggct gaaaagctga aggaaaaata 540cgaaaaggat attgctgcat atcgagctaa aggaaagcct gatgcagcaa aaaagggagt 600tgtcaaggct gaaaaaagca agaaaaagaa ggaagaggag gaaggtgagg aagatgaaga 660ggatgaggag gaggaggaag atgaagaaga tgaagatgaa gaagaagatg atgatgatga 720ataagttggt tctagcgcag tttttttttt cttgtctata aagcatttaa cccccctgta 780cacaactcac tccttttaaa gaaaaaaatt gaaatgtaag gctgtgtaag atttgttttt 840aaactgtaca gtgtcttttt ttgtatagtt aacacactac cgaatgtgtc tttagatagc 900cctgtcctgg tggtatcttc aatagccact aaccctgcct ggtacagtat gggggttgta 960aattggcatg gaaatttaaa gcaggttctt gtttgggcac agcacaaatt agttatatat 1020ggggatggta gttttttcat cttcagttgt ctctgatgca gctatacgaa ataattgttg 1080ttctgttaac tgaataccac tctgtaattg caaaaaaaaa aaaaaagttg cagctgtttt 1140gttgacattc tgaatgcttc taagtaaata caattttttt tattaaaaaa aaaa 1194 32 1805 DNA Homo sapiens 32aagagactga actgtatctg cctctatttc caaaagactc acgttcaact ttcgctcaca 60caaagccggg aaaattttat tagtcctttt tttaaaaaaa gttaatataa aattatagca 120aaaaaaaaaa ggaacctgaa ctttagtaac acagctggaa caatcgcagc ggcggcggca 180gcggcgggag aagaggttta atttagttga ttttctgtgg ttgttggttg ttcgctagtc 240tcacggtgat ggaagctgca cattttttcg aagggaccga gaagctgctg gaggtttggt 300tctcccggca gcagcccgac gcaaaccaag gatctgggga tcttcgcact atcccaagat 360ctgagtggga catacttttg aaggatgtgc aatgttcaat cataagtgtg acaaaaactg 420acaagcagga agcttatgta ctcagtgaga gtagcatgtt tgtctccaag agacgtttca 480ttttgaagac atgtggtacc accctcttgc tgaaagcact ggttcccctg ttgaagcttg 540ctagggatta cagtgggttt gactcaattc aaagcttctt ttattctcgt aagaatttca 600tgaagccttc tcaccaaggg tacccacacc ggaatttcca ggaagaaata gagtttctta 660atgcaatttt cccaaatgga gcaggatatt gtatgggacg tatgaattct gactgttggt 720acttatatac tctggatttc ccagagagtc gggtaatcag tcagccagat caaaccttgg 780aaattctgat gagtgagctt gacccagcag ttatggacca gttctacatg aaagatggtg 840ttactgcaaa ggatgtcact cgtgagagtg gaattcgtga cctgatacca ggttctgtca 900ttgatgccac aatgttcaat ccttgtgggt attcgatgaa tggaatgaaa tcggatggaa 960cttattggac tattcacatc actccagaac cagaattttc ttatgttagc tttgaaacaa 1020acttaagtca gacctcctat gatgacctga tcaggaaagt tgtagaagtc ttcaagccag 1080gaaaatttgt gaccaccttg tttgttaatc agagttctaa atgtcgcaca gtgcttgctt 1140cgccccagaa gattgaaggt tttaagcgtc ttgattgcca gagtgctatg ttcaatgatt 1200acaattttgt ttttaccagt tttgctaaga agcagcaaca acagcagagt tgattaagaa 1260aaatgaagaa aaaacgcaaa aagagaacac atgtagaagg tggtggatgc tttctagatg 1320tcgatgctgg gggcagtgct ttccataacc accactgtgt agttgcagaa agccctagat 1380gtaatgatag tgtaatcatt ttgaattgta tgcattatta tatcaaggag ttagatatct 1440tgcatgaatg ctctcttctg tgtttaggta ttctctgcca ctcttgctgt gaaattgaag 1500tggatgtaga aaaaaccttt tactatatga aactttacaa cacttgtgaa agcaactcaa 1560tttggtttat gcacagtgta atatttctcc aagtatcatc caaaattccc cacagacaag 1620gctttcgtcc tcattaggtg ttggcctcag cctaaccctc taggactgtt ctattaaatt 1680gctgccagaa ttttacatcc agttacctcc actttctaga acatattctt tactaatgtt 1740attgaaacca atttctactt catactgatg tttttggaaa cagcaattaa agtttttctt 1800ccatg 1805 33 3907 DNA Homo sapiens 33ctactgttgt ttttgagggg cgggcagccg cgccgccgcg gcactttttt aattttttcg 60ggtgccgcag cagcgacccc tcggcgccga tgtccctgat ccctggagcg acgacggccg 120ctgcctaagc tgggaagagg aatgccagct cctgagcagg cctcattggt ggaggagggg 180caaccacaga cccgccagga agctgcctcc actggcccag gcatggaacc cgagaccaca 240gccaccacta ttctagcatc cgtgaaggag caggagcttc agtttcagcg actcacccga 300gaactggaag tggaaaggca gattgttgcc agtcagctag aaagatgtag gcttggagca 360gaatcaccaa gcatcgccag caccagctca actgagaagt catttccttg gagatcaaca 420gacgtgccaa atactggtgt aagcaaacct agagtttctg acgctgtcca gcccaacaac 480tatctcatca ggacagagcc agaacaagga accctctatt caccagaaca gacatctctc 540catgaaagtg agggatcatt gggtaactca agaagttcaa cacaaatgaa ttcttattcc 600gacagtggat accaggaagc agggagtttc cacaacagcc agaacgtgag caaggcagac 660aacagacagc agcattcatt cataggatca actaacaacc atgtggtgag gaattcaaga 720gctgaaggac aaacactggt tcagccatca gtagccaatc gggccatgag aagagttagt 780tcagttccat ctagagcaca gtctccttct tatgttatca gcacaggcgt gtctccttca 840agggggtctc tgagaacttc tctgggtagt ggatttggct ctccgtcagt gaccgacccc 900cgacctctga accccagtgc atattcctcc accacattac ctgctgcacg ggcagcctct 960ccgtactcac agagacccgc ctccccaaca gctatacggc ggattgggtc agtcacctcc 1020cggcagacct ccaatcccaa cggaccaacc cctcaatacc aaaccaccgc cagagtgggg 1080tccccactga ccctgacgga tgcacagact cgagtagctt ccccatccca aggccaggtg 1140gggtcgtcgt cccccaaacg ctcagggatg accgccgtac cacagcatct gggaccttca 1200ctgcaaagga ctgttcatga catggagcaa ttcggacagc agcagtatga catttatgag 1260aggatggttc cacccaggcc agacagcctg acaggcttac ggagttccta tgctagtcag 1320catagtcagc ttgggcaaga ccttcgttct gccgtgtctc ccgacttgca cattactcct 1380atatatgagg ggaggaccta ttacagccca gtgtaccgca gcccaaacca tggaactgtg 1440gagctccaag gatcgcagac ggcgttgtat cgcacaggtg tatcaggtat tggaaatcta 1500caaaggacat ccagccaacg aagtaccctt acataccaaa gaaataatta tgctctgaac 1560acaacagcta cctacgcgga gccctacagg cctatacaat accgagtgca agagtgcaat 1620tataacaggc ttcagcatgc agtgccggct gatgatggca ccacaagatc cccatcaata 1680gacagcattc agaaggaccc cagggagttt gcctggcgtg atcctgagtt gcctgaggtc 1740attcacatgc ttgagcacca gttcccatct gttcaggcaa atgcagcggc ctacctgcag 1800cacctgtgct ttggtgacaa caaagtgaag atggaggtgt gtaggttagg gggaatcaag 1860catctggttg accttctgga ccacagagtt ttggaagttc agaagaatgc ttgtggtgcc 1920cttcgaaacc tcgtttttgg caagtctaca gatgaaaata aaatagcaat gaagaatgtt 1980ggtgggatac ctgccttgtt gcgactgttg agaaaatcta ttgatgcaga agtaagggag 2040cttgttacag gagttctttg gaatttatcc tcatgtgatg ctgtaaaaat gacaatcatt 2100cgagatgctc tctcaacctt aacaaacact gtgattgttc cacattctgg atggaataac 2160tcttcttttg atgatgatca taaaattaaa tttcagactt cactagttct gcgtaacacg 2220acaggttgcc taaggaacct cacgtccgcg ggggaagaag ctcggaagca aatgcggtcc 2280tgcgaggggc tggtagactc actgttgtat gtgatccaca cgtgtgtgaa cacatccgat 2340tacgacagca agacggtgga gaactgcgtg tgcaccctga ggaacctgtc ctatcggctg 2400gagctggagg tgccccaggc ccggttactg ggactgaacg aattggatga cttactagga 2460aaagagtctc ccagcaaaga ctctgagcca agttgctggg ggaagaagaa gaaaaagaaa 2520aagaggactc cgcaagaaga tcaatgggat ggagttggtc ctatcccagg actgtcgaag 2580tcccccaaag gggttgagat gctgtggcac ccatcggtgg taaaaccata tctgactctt 2640ctagcagaaa gttccaaccc agccaccttg gaaggctctg cagggtctct ccagaacctc 2700tctgctagca actggaagtt tgcagcatat atccggggcg gccgtccgaa aagaaaaggg 2760ctccccatcc ttgtggagct tctgagaatg gataacgata gagttgtttc ttccggtgca 2820acagccttga ggaatatggc actagatgtt cgcaacaagg agctcatagg caaatacgcc 2880atgcgagacc tggtcaaccg gctccccggc ggcaatggcc ccagtgtctt gtctgatgag 2940accatggcag ccatctgctg tgctctgcac gaggtcacca gcaaaaacat ggagaacgca 3000aaagccctgg ccgactcagg aggcatagag aagctggtga acataaccaa aggcaggggc 3060gacagatcat ctctgaaagt ggtgaaggca gcagcccagg tcttgaatac attatggcaa 3120tatcgggacc tccggagcat ttataaaaag gatgggtgga atcagaacca ttttattaca 3180cctgtgtcga cattggagcg agaccgattc aaatcacatc cttccttgtc taccaccaac 3240caacagatgt cacccatcat tcagtcagtc ggcagcacct cttcctcacc agcactgtta 3300ggaatcagag accctcgctc tgaatacgat aggacccagc cacctatgca gtattacaat 3360agccaagggg atgccacaca taaaggcctg taccctggct ccagcaaacc ttcaccaatt 3420tacatcagtt cctattcctc accagcaaga gaacaaaata gacggctaca gcatcaacag 3480ctgtattata gtcaagatga ctccaacaga aagaactttg atgcatacag attgtatttg 3540cagtctcctc atagctatga agatccttat tttgatgacc gagttcactt tccagcttct 3600actgattact caacacagta tggactgaaa tcgaccacaa attatgtaga cttttattcc 3660actaaacgac cttcttatag agcagaacag tacccagggt ccccagactc atgggtgtac 3720gatcaagatg cccaacagag gaactctttc tttctaacct tgttcagatt gaggtgaaaa 3780gtccatcttg ctgatttcat gattgaaatg tgaaagtgaa gtggaaggaa tgaatgaagt 3840gtgttttttt ttcctttttg aggaattatc aggggaattc gatatcaagc ttatcgatac 3900cgtcgac 3907 34 568 DNA Homo sapiens misc_feature (1)...(568) n = A,T,C or G 34cagtgaaaat acaactttat attaatcatc tcaataatac agattacaga actgagttta 60cagattacag aacttttcat actttgtggg tcagaaagga taaccgtaaa ttactgtctc 120cgctttatgg gtggtaaaac tgagccacag agaaatttct ctaagaaaat ttaaaaggaa 180ttgatgttca ttaaataaat atcctcactg atttttttaa ggtagaaaag tacaatgcac 240agtgttaaaa aaattactgt aacagcctca tgttcgagaa gtctaaaatt ttaaggctac 300tacatgtgtt aattttcagt acatgtccaa cagaaaacat cctttattcc agttacatcc 360tgaagatacc gaagtcagtc ttctctattg gtgcgttgag ggctgcacta aaactggaga 420cccaagacca gtctggtgtc tgctgggatc aatgatccca tcatcccata cccctgcgct 480gggaatagta aggggttccc tcctcttcca acntcctaat ggatggggcc cttttaaagc 540cgcttcatca gcactggggn actgcttt 568 35 362 DNA Homo sapiens 35gtcggctctt agagtagtaa ccgccagaaa ggagtcggaa gaggtctcac gaggctgtca 60tcaccgccat gcccaagaat aaaggtaaag gaggtaaaaa caggcgcagg ggtaaaaatg 120agaatgaatc tgaaaaaaga gagttggtgt ttaaagagga tggacaagag tatgctcagg 180taatcaaaat gttgggaaat ggacgattgg aagcattgtg ttttgatggt gtaaagaggt 240tatgccatat cagagggaaa ttgagaaaaa aggtttggat aaatacatca gacattatat 300tggttggtct acgggactat caggataaca aagctgatgt aatttttaaa gtacattgca 360ga 362 36 1661 DNA Homo sapiens 36tgctgcagcc gctgccgccg attccggatc tcattgccac gcgcccccga cgaccgcccg 60acgtgcattc ccgattcctt ttggttccaa gtccaatatg gcaactctaa aggatcagct 120gatttataat cttctaaagg aagaacagac cccccagaat aagattacag ttgttggggt 180tggtgctgtt ggcatggcct gtgccatcag tatcttaatg aaggacttgg cagatgaact 240tgctcttgtt gatgtcatcg aagacaaatt gaagggagag atgatggatc tccaacatgg 300cagccttttc cttagaacac caaagattgt ctctggcaaa gactataatg taactgcaaa 360ctccaagctg gtcattatca cggctggggc acgtcagcaa gagggagaaa gccgtcttaa 420tttggtccag cgtaacgtga acatatttaa attcatcatt cctaatgttg taaaatacag 480cccgaactgc aagttgctta ttgtttcaaa tccagtggat atcttgacct acgtggcttg 540gaagataagt ggttttccca aaaaccgtgt tattggaagt ggttgcaatc tggattcagc 600ccgattccgt tacctgatgg gggaaaggct gggagttcac ccattaagct gtcatgggtg 660ggtccttggg gaacatggag attccagtgt gcctgtatgg agtggaatga atgttgctgg 720tgtctctctg aagactctgc acccagattt agggactgat aaagataagg aacagtggaa 780agaggttcac aagcaggtgg ttgagagtgc ttatgaggtg atcaaactca aaggctacac 840atcctgggct attggactct ctgtagcaga tttggcagag agtataatga agaatcttag 900gcgggtgcac ccagtttcca ccatgattaa gggtctttac ggaataaagg atgatgtctt 960ccttagtgtt ccttgcattt tgggacagaa tggaatctca gaccttgtga aggtgactct 1020gacttctgag gaagaggccc gtttgaagaa gagtgcagat acactttggg ggatccaaaa 1080ggagctgcaa ttttaaagtc ttctgatgtc atatcatttc actgtctagg ctacaacagg 1140attctaggtg gaggttgtgc atgttgtcct ttttatctga tctgtgatta aagcagtaat 1200attttaagat ggactgggaa aaacatcaac tcctgaagtt agaaataaga atggtttgta 1260aaatccacag ctatatcctg atgctggatg gtattaatct tgtgtagtct tcaactggtt 1320agtgtgaaat agttctgcca cctctgacgc accactgcca atgctgtacg tactgcattt 1380gccccttgag ccaggtggat gtttaccgtg tgttatataa cttcctggct ccttcactga 1440acatgcctag tccaacattt tttcccagtg agtcacatcc tgggatccag tgtataaatc 1500caatatcatg tcttgtgcat aattcttcca aaggatctta ttttgtgaac tatatcagta 1560gtgtacatta ccatataatg taaaaagatc tacatacaaa caatgcaacc aactatccaa 1620gtgttatacc aactaaaacc cccaataaac cttgaacagt g 1661 37 743 DNA Homo sapiens 37cagccagctc gacggggctg tgtgtgctgg gcctggctcg cggcgaaccg agatggcaga 60gcagtcggac gaggccgtga agtactacac cctagaggag attcagaagc acaaccacag 120caagagcacc tggctgatcc tgcaccacaa ggtgtacgat ttgaccaaat ttctggaaga 180gcatcctggt ggggaagaag ttttaaggga acaagctgga ggtgacgcta ctgagaactt 240tgaggatgtc gggcactcta cagatgccag ggaaatgtcc aaaacattca tcattgggga 300gctccatcca gatgacagac caaagttaaa caagcctccg gaaactctta tcactactat 360tgattctagt tccagttggt ggaccaactg ggtgatccct gccatctctg cagtggccgt 420cgccttgatg tatcgcctat acatggcaga ggactgaaca cctcctcaga agtcagcgca 480ggccgagcct gctttggaca cgggagaaaa gaagccattg ctaactactt caactgacag 540aaaccttcac ttgaaaacaa tgattttaat atatctcttt ctttttcttc cgacattaga 600aacaaaacaa aaagaactgt cctttctgcg ctcaaatttt tcgagtgtgc ctttttattc 660atctacttta ttttgatgtt tccttaatgt gtaatttact tattataagc atgatctttt 720aaaaatatat ttggctttta aag 743 38 7679 DNA Homo sapiens 38gaagagcaag aggcaggctc agcaaatggt tcagccccag tccccggtgg ctgtcagtca 60aagcaagccc ggttgttatg acaatggaaa acactatcag ataaatcaac agtgggagcg 120gacctaccta ggtaatgtgt tggtttgtac ttgttatgga ggaagccgag gttttaactg 180cgaaagtaaa cctgaagctg aagagacttg ctttgacaag tacactggga acacttaccg 240agtgggtgac acttatgagc gtcctaaaga ctccatgatc tgggactgta cctgcatcgg 300ggctgggcga gggagaataa gctgtaccat cgcaaaccgc tgccatgaag ggggtcagtc 360ctacaagatt ggtgacacct ggaggagacc acatgagact ggtggttaca tgttagagtg 420tgtgtgtctt ggtaatggaa aaggagaatg gacctgcaag cccatagctg agaagtgttt 480tgatcatgct gctgggactt cctatgtggt cggagaaacg tgggagaagc cctaccaagg 540ctggatgatg gtagattgta cttgcctggg agaaggcagc ggacgcatca cttgcacttc 600tagaaataga tgcaacgatc aggacacaag gacatcctat agaattggag acacctggag 660caagaaggat aatcgaggaa acctgctcca gtgcatctgc acaggcaacg gccgaggaga 720gtggaagtgt gagaggcaca cctctgtgca gaccacatcg agcggatctg gccccttcac 780cgatgttcgt gcagctgttt accaaccgca gcctcacccc cagcctcctc cctatggcca 840ctgtgtcaca gacagtggtg tggtctactc tgtggggatg cagtggttga agacacaagg 900aaataagcaa atgctttgca cgtgcctggg caacggagtc agctgccaag agacagctgt 960aacccagact tacggtggca acttaaatgg agagccatgt gtcttaccat tcacctacaa 1020tggcaggacg ttctactcct gcaccacgga agggcgacag gacggacatc tttggtgcag 1080cacaacttcg aattatgagc aggaccagaa atactctttc tgcacagacc acactgtttt 1140ggttcagact caaggaggaa attccaatgg tgccttgtgc cacttcccct tcctatacaa 1200caaccacaat tacactgatt gcacttctga gggcagaaga gacaacatga agtggtgtgg 1260gaccacacag aactatgatg ccgaccagaa gtttgggttc tgccccatgg ctgcccacga 1320ggaaatctgc acaaccaatg aaggggtcat gtaccgcatt ggagatcagt gggataagca 1380gcatgacatg ggtcacatga tgaggtgcac gtgtgttggg aatggtcgtg gggaatggac 1440atgcattgcc tactcgcaac ttcgagatca gtgcattgtt gatgacatca cttacaatgt 1500gaacgacaca ttccacaagc gtcatgaaga ggggcacatg ctgaactgta catgcttcgg 1560tcagggtcgg ggcaggtgga agtgtgatcc cgtcgaccaa tgccaggatt cagagactgg 1620gacgttttat caaattggag attcatggga gaagtatgtg catggtgtca gataccagtg 1680ctactgctat ggccgtggca ttggggagtg gcattgccaa cctttacaga cctatccaag 1740ctcaagtggt cctgtcgaag tatttatcac tgagactccg agtcagccca actcccaccc 1800catccagtgg aatgcaccac agccatctca catttccaag tacattctca ggtggagacc 1860taaaaattct gtaggccgtt ggaaggaagc taccatacca ggccacttaa actcctacac 1920catcaaaggc ctgaagcctg gtgtggtata cgagggccag ctcatcagca tccagcagta 1980cggccaccaa gaagtgactc gctttgactt caccaccacc agcaccagca cacctgtgac 2040cagcaacacc gtgacaggag agacgactcc cttttctcct cttgtggcca cttctgaatc 2100tgtgaccgaa atcacagcca gtagctttgt ggtctcctgg gtctcagctt ccgacaccgt 2160gtcgggattc cgggtggaat atgagctgag tgaggaggga gatgagccac agtacctgga 2220tcttccaagc acagccactt ctgtgaacat ccctgacctg cttcctggcc gaaaatacat 2280tgtaaatgtc tatcagatat ctgaggatgg ggagcagagt ttgatcctgt ctacttcaca 2340aacaacagcg cctgatgccc ctcctgaccc gactgtggac caagttgatg acacctcaat 2400tgttgttcgc tggagcagac cccaggctcc catcacaggg tacagaatag tctattcgcc 2460atcagtagaa ggtagcagca cagaactcaa ccttcctgaa actgcaaact ccgtcaccct 2520cagtgacttg caacctggtg ttcagtataa catcactatc tatgctgtgg aagaaaatca 2580agaaagtaca cctgttgtca ttcaacaaga aaccactggc accccacgct cagatacagt 2640gccctctccc agggacctgc agtttgtgga agtgacagac gtgaaggtca ccatcatgtg 2700gacaccgcct gagagtgcag tgaccggcta ccgtgtggat gtgatccccg tcaacctgcc 2760tggcgagcac gggcagaggc tgcccatcag caggaacacc tttgcagaag tcaccgggct 2820gtcccctggg gtcacctatt acttcaaagt ctttgcagtg agccatggga gggagagcaa 2880gcctctgact gctcaacaga caaccaaact ggatgctccc actaacctcc agtttgtcaa 2940tgaaactgat tctactgtcc tggtgagatg gactccacct cgggcccaga taacaggata 3000ccgactgacc gtgggcctta cccgaagagg ccagcccagg cagtacaatg tgggtccctc 3060tgtctccaag taccccctga ggaatctgca gcctgcatct gagtacaccg tatccctcgt 3120ggccataaag ggcaaccaag agagccccaa agccactgga gtctttacca cactgcagcc 3180tgggagctct attccacctt acaacaccga ggtgactgag accaccatcg tgatcacatg 3240gacgcctgct ccaagaattg gttttaagct gggtgtacga ccaagccagg gaggagaggc 3300accacgagaa gtgacttcag actcaggaag catcgttgtg tccggcttga ctccaggagt 3360agaatacgtc tacaccatcc aagtcctgag agatggacag gaaagagatg cgccaattgt 3420aaacaaagtg gtgacaccat tgtctccacc aacaaacttg catctggagg caaaccctga 3480cactggagtg ctcacagtct cctgggagag gagcaccacc ccagacatta ctggttatag 3540aattaccaca acccctacaa acggccagca gggaaattct ttggaagaag tggtccatgc 3600tgatcagagc tcctgcactt ttgataacct gagtcccggc ctggagtaca atgtcagtgt 3660ttacactgtc aaggatgaca aggaaagtgt ccctatctct gataccatca tcccagctgt 3720tcctcctccc actgacctgc gattcaccaa cattggtcca gacaccatgc gtgtcacctg 3780ggctccaccc ccatccattg atttaaccaa cttcctggtg cgttactcac ctgtgaaaaa 3840tgaggaagat gttgcagagt tgtcaatttc tccttcagac aatgcagtgg tcttaacaaa 3900tctcctgcct ggtacagaat atgtagtgag tgtctccagt gtctacgaac aacatgagag 3960cacacctctt agaggaagac agaaaacagg tcttgattcc ccaactggca ttgacttttc 4020tgatattact gccaactctt ttactgtgca ctggattgct cctcgagcca ccatcactgg 4080ctacaggatc cgccatcatc ccgagcactt cagtgggaga cctcgagaag atcgggtgcc 4140ccactctcgg aattccatca ccctcaccaa cctcactcca ggcacagagt atgtggtcag 4200catcgttgct cttaatggca gagaggaaag tcccttattg attggccaac aatcaacagt 4260ttctgatgtt ccgagggacc tggaagttgt tgctgcgacc cccaccagcc tactgatcag 4320ctgggatgct cctgctgtca cagtgagata ttacaggatc acttacggag aaacaggagg 4380aaatagccct gtccaggagt tcactgtgcc tgggagcaag tctacagcta ccatcagcgg 4440ccttaaacct ggagttgatt ataccatcac tgtgtatgct gtcactggcc gtggagacag 4500ccccgcaagc agcaagccaa tttccattaa ttaccgaaca gaaattgaca aaccatccca 4560gatgcaagtg accgatgttc aggacaacag cattagtgtc aagtggctgc cttcaagttc 4620ccctgttact ggttacagag taaccaccac tcccaaaaat ggaccaggac caacaaaaac 4680taaaactgca ggtccagatc aaacagaaat gactattgaa ggcttgcagc ccacagtgga 4740gtatgtggtt agtgtctatg ctcagaatcc aagcggagag agtcagcctc tggttcagac 4800tgcagtaacc aacattgatc gccctaaagg actggcattc actgatgtgg atgtcgattc 4860catcaaaatt gcttgggaaa gcccacaggg gcaagtttcc aggtacaggg tgacctactc 4920gagccctgag gatggaatcc atgagctatt ccctgcacct gatggtgaag aagacactgc 4980agagctgcaa ggcctcagac cgggttctga gtacacagtc agtgtggttg ccttgcacga 5040tgatatggag agccagcccc tgattggaac ccagtccaca gctattcctg caccaactga 5100cctgaagttc actcaggtca cacccacaag cctgagcgcc cagtggacac cacccaatgt 5160tcagctcact ggatatcgag tgcgggtgac ccccaaggag aagaccggac caatgaaaga 5220aatcaacctt gctcctgaca gctcatccgt ggttgtatca ggacttatgg tggccaccaa 5280atatgaagtg agtgtctatg ctcttaagga cactttgaca agcagaccag ctcagggtgt 5340tgtcaccact ctggagaatg tcagcccacc aagaagggct cgtgtgacag atgctactga 5400gaccaccatc accattagct ggagaaccaa gactgagacg atcactggct tccaagttga 5460tgccgttcca gccaatggcc agactccaat ccagagaacc atcaagccag atgtcagaag 5520ctacaccatc acaggtttac aaccaggcac tgactacaag atctacctgt acaccttgaa 5580tgacaatgct cggagctccc ctgtggtcat cgacgcctcc actgccattg atgcaccatc 5640caacctgcgt ttcctggcca ccacacccaa ttccttgctg gtatcatggc agccgccacg 5700tgccaggatt accggctaca tcatcaagta tgagaagcct gggtctcctc ccagagaagt 5760ggtccctcgg ccccgccctg gtgtcacaga ggctactatt actggcctgg aaccgggaac 5820cgaatataca atttatgtca ttgccctgaa gaataatcag aagagcgagc ccctgattgg 5880aaggaaaaag acagacgagc ttccccaact ggtaaccctt ccacacccca atcttcatgg 5940accagagatc ttggatgttc cttccacagt tcaaaagacc cctttcgtca cccaccctgg 6000gtatgacact ggaaatggta ttcagcttcc tggcacttct ggtcagcaac ccagtgttgg 6060gcaacaaatg atctttgagg aacatggttt taggcggacc acaccgccca caacggccac 6120ccccataagg cataggccaa gaccataccc gccgaatgta ggacaagaag ctctctctca 6180gacaaccatc tcatgggccc cattccagga cacttctgag tacatcattt catgtcatcc 6240tgttggcact gatgaagaac ccttacagtt cagggttcct ggaacttcta ccagtgccac 6300tctgacaggc ctcaccagag gtgccaccta caacatcata gtggaggcac tgaaagacca 6360gcagaggcat aaggttcggg aagaggttgt taccgtgggc aactctgtca acgaaggctt 6420gaaccaacct acggatgact cgtgctttga cccctacaca gtttcccatt atgccgttgg 6480agatgagtgg gaacgaatgt ctgaatcagg ctttaaactg ttgtgccagt gcttaggctt 6540tggaagtggt catttcagat gtgattcatc tagatggtgc catgacaatg gtgtgaacta 6600caagattgga gagaagtggg accgtcaggg agaaaatggc cagatgatga gctgcacatg 6660tcttgggaac ggaaaaggag aattcaagtg tgaccctcat gaggcaacgt gttacgatga 6720tgggaagaca taccacgtag gagaacagtg gcagaaggaa tatctcggtg ccatttgctc 6780ctgcacatgc tttggaggcc agcggggctg gcgctgtgac aactgccgca gacctggggg 6840tgaacccagt cccgaaggca ctactggcca gtcctacaac cagtattctc agagatacca 6900tcagagaaca aacactaatg ttaattgccc aattgagtgc ttcatgcctt tagatgtaca 6960ggctgacaga gaagattccc gagagtaaat catctttcca atccagagga acaagcatgt 7020ctctctgcca agatccatct aaactggagt gatgttagca gacccagctt agagttcttc 7080tttctttctt aagccctttg ctctggagga agttctccag cttcagctca actcacagct 7140tctccaagca tcaccctggg agtttcctga gggttttctc ataaatgagg gctgcacatt 7200gcctgttctg cttcgaagta ttcaataccg ctcagtattt taaatgaagt gattctaaga 7260tttggtttgg gatcaatagg aaagcatatg cagccaacca agatgcaaat gttttgaaat 7320gatatgacca aaattttaag taggaaagtc acccaaacac ttctgctttc acttaagtgt 7380ctggcccgca atactgtagg aacaagcatg atcttgttac tgtgatattt taaatatcca 7440cagtactcac tttttccaaa tgatcctagt aattgcctag aaatatcttt ctcttacctg 7500ttatttatca atttttccca gtatttttat acggaaaaaa ttgtattgaa aacacttaga 7560tgcagttgat aagaggaatt tggtataatt atggtgggtg attatttttt atactgtatg 7620tgccaaagct ttactactgt ggaaagacaa ctgttttaat aaaagattta cattccaca 7679 39 1441 DNA Homo sapiens 39caggctggtc aatgtggcaa ccagatcggt gccaagttct gggaggtgat cagtgatgaa 60catggcatcg accccaccgg cacctaccac ggggacagcg acctgcagct ggaccgcatc 120tctgtgtact acaatgaagc cacaggtggc aaatatgttc ctcgtgccat cctggtggat 180ctagaacctg ggaccatgga ctctgttcgc tcaggtcctt ttggccagat ctttagacca 240gacaactttg tatttggtca gtctggggca ggtaacaact gggccaaagg ccactacaca 300gagggcgccg agctggttga ttctgtcctg gatgtggtac ggaaggaggc agagagctgt 360gactgcctgc agggcttcca gctgacccac tcactgggcg ggggcacagg ctctggaatg 420ggcactctcc ttatcagcaa gatccgagaa gaataccctg atcgcatcat gaataccttc 480agtgtggtgc cttcacccaa agtgtctgac accgtggtcg agccctacaa tgccaccctc 540tccgtccatc agttggtaga gaatactgat gagacctatt gcattgacaa cgaggccctc 600tatgatatct gcttccgcac tctgaggctg accacaccaa cctacgggga tctgaaccac 660cttgtctcag gcaccatgga gtgtgtcacc acctgcctcc gtttccctgg ccagctcaat 720gctgacctcc gcaagttggc agtcaacatg gtccccttcc cacgtctcca tttctttatg 780cctggctttg cccctctcac cagccgtgga agccagcagt atcgagctct cacagtgccg 840gacctcaccc agcaggtctt cgatgccaag aacatgatgg ctgcctgtga cccccgccac 900ggccgatacc tcaccgtggc tgctgtcttc cgtggtcgga tgtccatgaa ggaggtcgat 960gagcagatgc ttaacgtgca gaacaagaac agcagctact ttgtggaatg gatccccaac 1020aatgtcaaga cagccgtctg tgacatccca cctcgtggcc tcaagatggc agtcaccttc 1080attggcaata gcacagccat ccaggagctc ttcaagcgca tctcggagca gttcactgcc 1140atgttccgcc ggaaggcctt cctccactgg tacacaggcg agggcatgga cgagatggag 1200ttcaccgagg ctgagagcaa catgaacgac ctcgtctctg agtatcagca gtaccaggat 1260gccaccgcag aagaggagga ggatttcggt gaggaggccg aagaggaggc ctaaggagag 1320cccccatcac ctcaggcttc tcagttccct tagccgtctt actcaactgc cccctttcct 1380ctccctcaga atttgtgttt gctgcctcta tcttgttttt tgttttttct tctggggggg 1440g 1441 40 873 DNA Homo sapiens 40cagtttgaat cgcggtgcga ccgaaggagt aggtgctggg atcgtcaccg tggcaccgat 60tagccttttc tctgccttgc ttgcttgagc ttcagcggaa ttcgaaatgg ctggcggtaa 120ggctggaaag gactccggaa aggccaagac aaaggcggtt tcccgctcgc agagagccgg 180cttgcagttc ccagtgggcc gtattcatcg acacctaaaa tctaggacga ccagtcatgg 240acgtgtgggc gcgactgccg ctgtgtacag cgcagccatc ctggagtacc tcaccgcaga 300ggtacttgaa ctggcaggaa atgcatcaaa agacttaaag gtaaagcgta ttacccctcg 360tcacttgcaa cttgctattc gtggagatga agaattggat tctctcatca aggctacaat 420tgctggtggt ggtgtcattc cacacatcca caaatctctg attgggaaga aaggacaaca 480gaagactgtc taaaggatgc ctggattcct tgttatctca ggactctaaa tactctaaca 540gctgtccagt gttggtgatt ccagtggact gtatctctgt gaaaaacaca attttgcctt 600tttgtaattc tatttgagca agttggaagt ttaattagct ttccaaccaa ccaaatttct 660gcattcgagt cttaaccata tttaagtgtt actgtggctt caaagaagct attgattctg 720aagtagtggg ttttgattga gttgactgtt tttaaaaaac tgtttggatt ttaattgtga 780tgcagaagtt atagtaacaa acatttggtt ttgttcagac cttatttcca ctctggtgga 840taagttcaat aaaggtcata tcccaaacta aaa 873 41 2098 DNA Homo sapiens 41cctgccgaag tcagttcctt gtggagccgg agctgggcgc ggattcgccg aggcaccgag 60gcactcagag gaggcgccat gtcagaaccg gctggggatg tccgtcagaa cccatgcggc 120agcaaggcct gccgccgcct cttcggccca gtggacagcg agcagctgag ccgcgactgt 180gatgcgctaa tggcgggctg catccaggag gcccgtgagc gatggaactt cgactttgtc 240accgagacac cactggaggg tgacttcgcc tgggagcgtg tgcggggcct tggcctgccc 300aagctctacc ttcccacggg gccccggcga ggccgggatg agttgggagg aggcaggcgg 360cctggcacct cacctgctct gctgcagggg acagcagagg aagaccatgt ggacctgtca 420ctgtcttgta cccttgtgcc tcgctcaggg gagcaggctg aagggtcccc aggtggacct 480ggagactctc agggtcgaaa acggcggcag accagcatga cagatttcta ccactccaaa 540cgccggctga tcttctccaa gaggaagccc taatccgccc acaggaagcc tgcagtcctg 600gaagcgcgag ggcctcaaag gcccgctcta catcttctgc cttagtctca gtttgtgtgt 660cttaattatt atttgtgttt taatttaaac acctcctcat gtacataccc tggccgcccc 720ctgcccccca gcctctggca ttagaattat ttaaacaaaa actaggcggt tgaatgagag 780gttcctaaga gtgctgggca tttttatttt atgaaatact atttaaagcc tcctcatccc 840gtgttctcct tttcctctct cccggaggtt gggtgggccg gcttcatgcc agctacttcc 900tcctccccac ttgtccgctg ggtggtaccc tctggagggg tgtggctcct tcccatcgct 960gtcacaggcg gttatgaaat tcaccccctt tcctggacac tcagacctga attctttttc 1020atttgagaag taaacagatg gcactttgaa ggggcctcac cgagtggggg catcatcaaa 1080aactttggag tcccctcacc tcctctaagg ttgggcaggg tgaccctgaa gtgagcacag 1140cctagggctg agctggggac ctggtaccct cctggctctt gatacccccc tctgtcttgt 1200gaaggcaggg ggaaggtggg gtcctggagc agaccacccc gcctgccctc atggcccctc 1260tgacctgcac tggggagccc gtctcagtgt tgagcctttt ccctctttgg ctcccctgta 1320ccttttgagg agccccagct acccttcttc tccagctggg ctctgcaatt cccctctgct 1380gctgtccctc ccccttgtcc tttcccttca gtaccctctc agctccaggt ggctctgagg 1440tgcctgtccc acccccaccc ccagctcaat ggactggaag gggaagggac acacaagaag 1500aagggcaccc tagttctacc tcaggcagct caagcagcga ccgccccctc ctctagctgt 1560gggggtgagg gtcccatgtg gtggcacagg cccccttgag tggggttatc tctgtgttag 1620gggtatatga tgggggagta gatctttcta ggagggagac actggcccct caaatcgtcc 1680agcgaccttc ctcatccacc ccatccctcc ccagttcatt gcactttgat tagcagcgga 1740acaaggagtc agacatttta agatggtggc agtagaggct atggacaggg catgccacgt 1800gggctcatat ggggctggga gtagttgtct ttcctggcac taacgttgag cccctggagg 1860cactgaagtg cttagtgtac ttggagtatt ggggtctgac cccaaacacc ttccagctcc 1920tgtaacatac tggcctggac tgttttctct cggctcccca tgtgtcctgg ttcccgtttc 1980tccacctaga ctgtaaacct ctcgagggca gggaccacac cctgtactgt tctgtgtctt 2040tcacagctcc tcccacaatg ctgatataca gcaggtgctc aataaacgat tcttagtg 2098 42 1914 DNA Homo sapiens 42gcagccaggc gcgcactgca cagctctctt ctctcgccgc cgcccgagcg cacccttcag 60cccgcgcgcc ggccgtgagt cctcggtgct cgcccgccgg ccagacaaac agcccgcccg 120accccgtccc gaccctggcc gccccgagcg gagcctggag caaaatgatg cttcaacacc 180caggccaggt ctctgcctcg gaagtgagtg cttctgccat cgtcccctgc ctgtcccctc 240ctgggtcact ggtgtttgag gattttgcta acctgacgcc ctttgtcaag gaagagctga 300ggtttgccat ccagaacaag cacctctgcc accggatgtc ctctgcgctg gaatcagtca 360ctgtcagcga cagacccctc ggggtgtcca tcacaaaagc cgaggtagcc cctgaagaag 420atgaaaggaa aaagaggcga cgagaaagaa ataagattgc agctgcaaag tgccgaaaca 480agaagaagga gaagacggag tgcctgcaga aagagtcgga gaagctggaa agtgtgaatg 540ctgaactgaa ggctcagatt gaggagctca agaacgagaa gcagcatttg atatacatgc 600tcaaccttca tcggcccacg tgtattgtcc gggctcagaa tgggaggact ccagaagatg 660agagaaacct ctttatccaa cagataaaag aaggaacatt gcagagctaa gcagtcgtgg 720tatgggggcg actggggagt cctcattgaa tcctcatttt atacccaaaa ccctgaagcc 780attggagagc tgtcttcctg tgtacctcta gaatcccagc agcagagaac catcaaggcg 840ggagggcctg cagtgattca gcaggccctt cccattctgc cccagagtgg gtcttggacc 900agggcaagtg catctttgcc tcaactccag gatttaggcc ttaacacact ggccattctt 960atgttccaga tggcccccag ctggtgtcct gcccgccttt catctggatt ctacaaaaaa 1020ccaggatgcc caccgttaga ttcaggcagc agtgtctgta cctcgggtgg gagggatggg 1080gccatctcct tcaccgtggc taccattgtc actcgtaggg gatgtggagt gagaacagca 1140tttagtgaag ttgtgcaacg gccagggttg tgctttctag caaatatgct gttatgtcca 1200gaaattgtgt gtgcaagaaa actaggcaat gtactcttcc gatgtttgtg tcacacaaca 1260ctgatgtgac ttttatatgc tttttctcag atctggtttc taagagtttt ggggggcggg 1320gctgtcacca cgtgcagtat ctcaagatat tcaggtggcc agaagagctt gtcagcaaga 1380ggaggaacag aattctccca gcgttaacac aaaatccatg ggcagcatga tggcaggtcc 1440tctgttgcaa actcagttcc aaagtcacag gaagaaagca gaaagttcaa cttccaaagg 1500gttaggactc tccactcaat gtcttaggtc aggagttgtg tctaggctgg aagagccaaa 1560gaaatattcc attttccttt ccttgtggtt gaaaccacag tcagtggaga gatgtttgga 1620acacagtcag tggagctggt ggtaccaggt ttagcattat tggatgtcaa aagcattttt 1680tttgtcatgt agctgtttta agaaatctgg cccagggtgt ttgcagctgt gagaagtcac 1740tcacactggc cacaaggacg ctggctactg tctattaaaa ttctgatgtt tctgtgaaat 1800tctcagagtg tttaattgta ctcaatggta tcattacaat tttctgtaag agaaaatatt 1860acttatttat cctagtattc ctaacctgtc agaataataa atattgtggt aaaa 1914 43 699 DNA Homo sapiens 43catccggtgt ggtcgacggg tcctccaaga gtttggggcg cggaccggag taccttgcgt 60gcagttatgt cggcgtcggt agtgtctgtc atttcgcggt tcttagaaga gtacttgagc 120tccactccgc agcgtctgaa gttgctggac gcgtacctgc tgtatatact gctgaccggg 180gcgctgcagt tcggttactg tctcctcgtg gggaccttcc ccttcaactc ttttctctcg 240ggcttcatct cttgtgtggg gagtttcatc ctagcggttt gcctgagaat acagatcaac 300ccacagaaca aagcggattt ccaaggcatc tccccagagc gagcctttgc tgattttctc 360tttgccagca ccatcctgca ccttgttgtc atgaactttg ttggctgaat cattctcatt 420tacttaattg aggagtagga gactaaaaga atgttcactc tttgaatttc ctggataaga 480gttctggaga tggcagctta ttggacacat ggattttctt cagatttgac acttactgct 540agctctgctt tttatgacag gagaaaagcc cagagttcac tgtgtgtcag aacaactttc 600taacaaacat ttattaatcc agcctctgcc tttcattaaa tgtaaccttt tgctttccaa 660attaaagaac tccatgccac tcctcaaaaa aaaaaaaaa 699 44 2049 DNA Homo sapiens 44gaattcgggg gggtagaaga cagaagtagc tcagggtcct gggggaatgg aggacatcca 60agcccgtcca ggaactatgg agatgggact ccctatgacc acatgaccag cagggacctt 120gggtcacatg acaatctctc tccacctttt gtcaattcca gaatacaaag taaaacagaa 180aggggctcat actcatctta tgggagagaa tcaaacttac agggttgcca ccagcagagt 240ctccttggag gtgacatgga tatgggcaac ccaggaaccc tttcgcccac caaacctggt 300tcccagtact atcagtattc tagcaataat ccccgaagga ggcctcttca cagtagtgcc 360atggaggtac agacaaagaa agttcgaaaa gttcctccag gtttgccatc ttcagtctat 420gctccatcag caagcactgc cgactacaat agggactcgc caggctatcc ttcctccaaa 480ccagcaacca gcactttccc tagctccttc ttcatgcaag atggccatca cagcagtgac 540ccttggagct cctccagtgg gatgaatcag cctggctatg caggaatgtt gggcaactct 600tctcatattc cacagtccag cagctactgt agcctgcatc cacatgaacg tttgagctat 660ccatcacact cctcagcaga catcaattcc agtcttcctc cgatgtccac tttccatcgt 720agtggtacaa accattacag cacctcttcc tgtacgcctc ctgccaacgg gacagacagt 780ataatggcaa atagaggaag cggggcagcc ggcagctccc agactggaga tgctctgggg 840aaagcacttg cttcgatcta ttcttcagat cacactaaca acagcttttc atcaaaccct 900tcaactcctg ttggctctcc tccatctctc tcagcaggca cagctgtttg gtctagaaat 960ggaggacagg cctcatcgtc tcctaattat gaaggaccct tacactcttt gcaaagccga 1020attgaagatc gtttagaaag actggatgat gctattcatg ttctccggaa ccatgcagtg 1080ggcccatcca cagctatgcc tggtggtcat ggggacatgc atggaatcat tggaccttct 1140cataatggag ccatgggtgg tctgggctca gggtatggaa ccggccttct ttcagccaac 1200agacattcac tcatggtggg gacccatcgt gaagatggcg tggccctgag aggcagccat 1260tctcttctgc caaaccaggt tccggttcca cagcttcctg tccagtctgc gacttcccct 1320gacctgaacc caccccagga cccttacaga ggcatgccac caggactaca ggggcagagt 1380gtctcctctg gcagctctga gatcaaatcc gatgacgagg gtgatgagaa cctgcaagac 1440acgaaatctt cggaggacaa gaaattagat gacgacaaga aggatatcaa atcaattact 1500agcaataatg acgatgagga cctgacacca gagcagaagg cagagcgtga gaaggagcgg 1560aggatggcca acaatgcccg agagcgtctg cgggtccgtg acatcaacga ggctttcaaa 1620gagctcggcc gcatggtgca gctccacctc aagagtgaca agccccagac caagctcctg 1680atcctccacc aggcggtggc cgtcatcctc agtctggagc agcaagtccg agaaaggaat 1740ctgaatccga aagctgcgtg tctgaaaaga agggaggaag agaaggtgtc ctcggagcct 1800ccccctctct ccttggccgg cccacaccct ggaatgggag acgcatcgaa tcacatggga 1860cagatgtaaa agggtccaag ttgccacatt gcttcattaa aacaagagac cacttcctta 1920acagctgtat tatcttaaac ccacataaac acttctcctt aacccccatt tttgtaatat 1980aagacaagtc tgagtagtta tgaatcgcag acgcaagagg tttcagcatt cccaattatc 2040aaaaaacag 2049 45 316 DNA Homo sapiens misc_feature (1)...(316) n = A,T,C or G 45tctatgtgta cagatgaatg ataaactctc tgcttctccc tctgcccctc tccaggcgcc 60ggcgggcgcg ccngtcttcg aagttgatgc aatcggttta aacatggctg aacgcgtgtg 120tacacgggac tgacgcaacc cacgtgtaac tgtcagccgg gccctgagta atcgcttaaa 180gatgttccta cgggcttgtt gctgttgatg ttttgttttg ttttgttttt tggtcttttt 240ttgtatnata aaaaataatc tatttctatg agaaaagacg gcgtctgtat atnttgggaa 300tcttttccgt ttcaag 316 46 3953 DNA Homo sapiens 46ggggtcacgg gcgaactaga acactgggaa aggggctgca ggttccggac cggaccggcc 60ctgacccgga ataatgagca aggagggtgt ggtgggttga aagccatcct actttactcc 120cgagttagag catggattca gttttagtct taagggggaa gtgagattgg agatttttat 180ttttaatttt gggcagaagc aggttgactc tagggatctc cagagcgaga ggatttaact 240tcatgttgct cccgtgtttg aaggaggaca ataaaagtcc caccgggcaa aattttcgta 300acctctgcgg tagaaaacgt caggtatctt ttaaatcgcg atagttttcg ctgtgtcagg 360ctttcttcgg tggagctccg agggtagcta ggttctaggt ttgaaacaga tgcagaatcc 420aaaggcagcg caaaaaacag ccaccgattt tgctatgtct ctgagctgcg agataatcag 480acagctaaat ggagtctgag cagctgttcc atagaggcta ctatagaaac agctacaaca 540gtataacaag tgcaagtagt gatgaggaac ttttagatgg agcaggtgtt attatggact 600ttcaaacatc tgaagatgac aatttattag atggtgacac tgcagttgga actcattata 660caatgacaaa tggaggcagc attaacagtt ctacacattt actggatctt ttggatgaac 720caattccagg tgttggtaca tatgatgatt tccatactat tgattgggtg cgagaaaaat 780gtaaagacag agaaaggcat agacggatca acagcaaaaa gaaagaatca gcatgggaaa 840tgacaaaaag tttgtatgat gcgtggtcag gatggctagt agtaacacta acaggattgg 900catcaggggc actggccgga ttaatagaca ttgctgccga ttggatgact gacctaaagg 960agggcatttg ccttagtgcg ttgtggtaca accacgaaca gtgctgttgg ggatctaatg 1020aaacaacatt tgaagagagg gataaatgtc cacagtggaa aacatgggca gaattaatca 1080taggtcaagc agagggtcct ggttcttata tcatgaacta cataatgtac atcttctggg 1140ccttgagttt tgcctttctt gcagtttccc tggtaaaggt atttgctcca tatgcctgtg 1200gctctggaat tccagagatt aaaactattt taagtggatt catcatcaga ggttacttgg 1260gaaaatggac tttaatgatt aaaaccatca cattagtcct ggctgtggca tcaggtttga 1320gtttaggaaa agaaggtccc ctggtacatg ttgcctgttg ctgcggaaat atcttttcct 1380acctctttcc aaagtatagc acaaacgaag ctaaaaaaag ggaggtgcta tcagctgcct 1440cagctgcagg ggtttctgta gcttttggtg caccaattgg aggagttctt tttagcctgg 1500aagaggttag ctattatttt cctctcaaaa ctttatggag atcatttttt gctgctttag 1560tggctgcatt tgttttgagg tccatcaatc catttggtaa cagccgtctg gtcctttttt 1620atgtggagta tcatacacca tggtaccttt ttgaactgtt tccttttatt cttctagggg 1680tatttggagg gctttgggga gcctttttca ttagggcaaa tattgcctgg tgtcgtcgac 1740gcaagtccac gaaatttgga aagtatcccg ttctggaagt cattattgtt gcagccatta 1800ctgctgtgat agccttccct aatccataca ctaggctaaa caccagtgaa ctgatcaaag 1860agctttttac agactgtggt cccctggaat cctcttctct ttgtgactac agaaatgaca 1920tgaatgccag taaaattgtc gatgacattc ctgatcgtcc agcaggcatt ggagtatatt 1980cagctatatg gcagttatgc ctggcactca tatttaaaat cataatgaca gtattcactt 2040ttggcatcaa ggttccatca ggcttgttca tccccagcat ggccattgga gcgatcgcag 2100gaaggattgt ggggattgcg gtggagcagc ttgcctacta tcaccacgac tggtttatct 2160ttaaggagtg gtgtgaggtc ggggctgatt gcattacacc tggcctttat gccatggttg 2220gtgctgctgc atgcttaggt ggtgtgacaa gaatgactgt ctccctggtg gttattgttt 2280ttgagcttac tggaggcttg gaatatattg ttccccttat ggctgcagtc atgaccagta 2340aatgggttgg agatgccttt ggcagggaag gcatttatga agcacacatc cgattaaatg 2400gatacccttt cttggatgca aaagaagaat tcgaattcac tcataccacc ctggctgctg 2460acgttatgag acctcgaagg aatgatcctc ccttagctgt cctgacacag gacaatatga 2520cagtggatga tatagaaaac atgattaatg aaaccagcta caatggattt cctgtcataa 2580tgtcaaaaga atctcagaga ttagtgggat ttgccctcag aagagacctg acaattgcaa 2640tagaaagtgc caggaaaaaa caagaaggta tcgttggcag ttctcgggtg tgttttgcac 2700agcacacccc atctcttcca gcagaaagtc ctcggccatt gaagcttcga agcattcttg 2760acatgagccc ttttacagtg acagaccaca ccccaatgga gattgtggtg gatattttcc 2820gaaagctggg actgaggcag tgccttgtaa ctcacaatgg gcgcctcctt ggcattataa 2880caaaaaaaga tatcctccgg catatggccc agacggcaaa ccaagacccc gcttcaataa 2940tgttcaactg aatctcacag atgaggagag agaagaaacg gaagaggaag tttatttgtt 3000gaatagcaca actctttaac ctgagggagt catctacttt tttttcctcc tttacaaaaa 3060aagaaaggaa atataaaagc cgggtttttg caacatggtt tgcaaataat gctggtggaa 3120tggaggagtt gtttggggag ggaaaggaga gagaaggaaa ggagtgaggt atttcccgtc 3180taacagaaag cagcgtatca actcctattg ttctgcactg gatgcattca gctgaggatg 3240tgcctgatag tgcaggcttg cgcctcaaca gagatgacag cagagtcctc gagcacctgg 3300cctgtttgct cacatgcaag acacatacag ccctattcta gaggatactt gaatggacct 3360ctataaacgc aaggttcttg ccttttttta atcaaaactg ttctgtttaa ttcatgaatt 3420gtatagttaa gcattacctt tctacattcc agaagagcct ttatttctct ctctctctct 3480ctctctctct ctctctctac tgagctgtaa caaagcctct ttaaatcggt gtatcctttt 3540gaagcagtcc tttctcatat tgagatgtac tgtgatttta ctgaggtttc atcacaagaa 3600gggagtgttt cttgtgccat taaccatgta gtttgtacca tcactaaatg cttggaacag 3660tacacatgca ccacaacaaa ggctcatcaa acaggtaaag tctcgaagga agcgagaacg 3720aaatctctca ttgtgtgccg tgtggctcaa aaccgaaaac aatgaagctt ggttttaaag 3780gataaagttt tcttttttgt tttcctctca gactttatgg ataatgtgac cgggtcttat 3840gcaaattttc tatttctaaa actactacta tgatatacaa gtgctgttga gcataattaa 3900ataaaatgct gctgctttga cagtaaagag aaggaagtat tctgaaaaaa aac 3953 47 2074 DNA Homo sapiens 47gaattcggca cgaggcgcgg cggctgcgac cgggacggcc cattttccgc cagctcgccg 60ctcgctatgg cgtcgctcac cgtgaaggcc taccttctgg gcaaggagga cgcggcgcgc 120gagattcgcc gcttcagctt ctgctgcagc cccgagcctg aggcggaagc cgaggctgcg 180gcgggtccgg gaccctgcga gcggctgctg agccgggtgg ccgccctgtt ccccgcgctg 240cggcctggcg gcttccaggc gcactaccgc gatgaggacg gggacttggt tgccttttcc 300agtgacgagg aattgacaat ggccatgtcc tacgtgaagg atgacatctt ccgaatctac 360attaaagaga aaaaagagtg ccggcgggac caccgcccac cgtgtgctca ggaggcgccc 420cgcaacatgg tgcaccccaa tgtgatctgc gatggctgca atgggcctgt ggtaggaacc 480cgctacaagt gcagcgtctg cccagactac gacttgtgta gcgtctgcga gggaaagggc 540ttgcaccggg ggcacaccaa gctcgcattc cccagcccct tcgggcacct gtctgagggc 600ttctcgcaca gccgctggct ccggaaggtg aaacacggac acttcgggtg gccaggatgg 660gaaatgggtc caccaggaaa ctggagccca cgtcctcctc gtgcagggga ggcccgccct 720ggccccacgg cagaatcagc ttctggtcca tcggaggatc cgagtgtgaa tttcctgaag 780aacgttgggg agagtgtggc agctgccctt agccctctgg gcattgaagt tgatatcgat 840gtggagcacg gagggaaaag aagccgcctg acccccgtct ctccagagag ttccagcaca 900gaggagaaga gcagctcaca gccaagcagc tgctgctctg accccagcaa gccgggtggg 960aatgttgagg gcgccacgca gtctctggcg gagcagatga ggaagatcgc cttggagtcc 1020gaggggcgcc ctgaggaaca gatggagtcg gataactgtt caggaggaga tgatgactgg 1080acccatctgt cttcaaaaga agtggacccg tctacaggtg aactccagtc cctacagatg 1140ccagaatccg aagggccaag ctctctggac ccctcccagg agggacccac agggctgaag 1200gaagctgcct tgtacccaca tctcccgcca gaggctgacc cgcggctgat tgagtccctc 1260tcccagatgc tgtccatggg cttctctgat gaaggcggct ggctcaccag gctcctgcag 1320accaagaact atgacatcgg agcggctctg gacaccatcc agtattcaaa gcatcccccg 1380ccgttgtgac cacttttgcc cacctcttct gcgtgcccct cttctgtctc atagttgtgt 1440taagcttgcg tagaattgca ggtctctgta cgggccagtt tctctgcctt cttccaggat 1500caggggttag ggtgcaagaa gccatttagg gcagcaaaac aagtgacatg aagggagggt 1560ccctgtgtgt gtgtgtgctg atgtttcctg ggtgccctgg ctccttgcag cagggctggg 1620cctgcgagac ccaaggctca ctgcagcgcg ctcctgaccc ctccctgcag gggctacgtt 1680agcagcccag cacatagctt gcctaatggc tttcactttc tcttttgttt taaatgactc 1740ataggtccct gacatttagt tgattatttt ctgctacaga cctggtacac tctgatttta 1800gataaagtaa gcctaggtgt tgtcagcagg caggctgggg aggccagtgt tgtgggcttc 1860ctgctgggac tgagaaggct cacgaagggc atccgcaatg ttggtttcac tgagagctgc 1920ctcctggtct cttcaccact gtagttctct catttccaaa ccatcagctg cttttaaaat 1980aagatctctt tgtagccatc ctgttaaatt tgtaaacaat ctaattaaat ggcatcagca 2040ctttaaccaa taaaaaaaaa aaaaaaaaaa aaaa 2074 48 1846 DNA Homo sapiens 48gcagtgcggc ggtcacaggc tgagtgctgc ggcgcgatcc ttgcttccct gagcgttggc 60ccgggaggaa agaagatggt gctggatctg gatttgtttc gggtggataa aggaggggac 120ccagccctca tccgagagac gcaggagaag cgcttcaagg acccgggact agtggaccag 180ctggtgaagg cagacagcga gtggcgacga tgtagatttc gggcagacaa cttgagcaag 240ctgaagaacc tatgcagcaa gacaatcgga gagaaaatga agaaaaaaga gccagtggga 300gatgatgagt ctgtcccaga gaatgtgctg agtttcgatg accttactgc agacgcttta 360gctaacctga aagtctcaca aatcaaaaaa gtccgactcc tcattgatga agccatcctg 420aagtgtgacg cggagcggat aaagttggaa gcagagcggt ttgagaacct ccgagagatt 480gggaaccttc tgcacccttc tgtacccatc agtaacgatg aggatgtgga caacaaagta 540gagaggattt ggggcgattg tacagtcagg aagaagtact ctcatgtgga cctggtggtg 600atggtagatg gctttgaagg cgaaaagggg gccgtggtgg ctgggagtcg agggtacttc 660ttgaaggggg tcctggtgtt cctggaacag gctctcatcc agtatgccct tcgcaccttg 720ggaagtcggg gctacattcc catttatacc ccctttttca tgaggaagga ggtcatgcag 780gaggtggcac agctcagcca gtttgatgaa gaactttata aggtgattgg caaaggcagt 840gaaaagtctg atgacaactc ctatgatgag aagtacctga ttgccacctc agagcagccc 900attgctgccc tgcaccggga tgagtggctc cggccggagg acctgcccat caagtatgct 960ggcctgtcta cctgcttccg tcaggaggtg ggctcccatg gccgtgacac ccgtggcatc 1020ttccgagtcc atcagtttga gaagattgaa cagtttgtgt actcatcacc ccatgacaac 1080aagtcatggg agatgtttga agagatgatt accaccgcag aggagttcta ccagtccctg 1140gggattcctt accacattgt gaatattgtc tcaggttctt tgaatcatgc tgccagtaag 1200aagcttgacc tggaggcctg gtttccgggc tcaggagcct tccgtgagtt ggtctcctgt 1260tctaattgca cggattacca ggctcgccgg cttcgaatcc gatatgggca aaccaagaag 1320atgatggaca aggtggagtt tgtccatatg ctcaatgcta ccatgtgcgc cactacccgt 1380accatctgcg ccatcctgga gaactaccag acagagaagg gcatcactgt gcctgagaaa 1440ttgaaggagt tcatgccgcc aggactgcaa gaactgatcc cctttgtgaa gcctgcgccc 1500attgagcagg agccatcaaa gaagcagaag aagcaacatg agggcagcaa aaagaaagca 1560gcagcaagag acgtcaccct agaaaacagg ctgcagaaca tggaggtcac cgatgcttga 1620acattcctgc ctccctattt gccaggcttt catttctgtc tgctgagatc tcagagcctg 1680cccaacagca gggaagccaa gcacccattc atccccctgc ccccatctga ctgcgtagct 1740gagaggggaa cagtgccatg taccacacag atgttcctgt ctcctcgcat gggcataggg 1800acccatcatt gatgactgat gaaaccatgt aataaagcat ctctgg 1846 49 1325 DNA Homo sapiens 49cagaagcggc tagtggcggc tgcctgcgtc cccaaccccc tccgcgcagc gctcgcgaca 60cgcgtgccag gagtgggagc gagcggcggg gccagctgcg ttctgagcct gggcgcagct 120gccatctgct ctgggaagca ccagggtgtc cccgccgccc tcagctcgaa gtcagccacc 180atggaggcgc aggcacaagg tttgttggag actgaaccgt tgcaaggaac agacgaagat 240gcagtagcca gtgctgactt ctctagcatg ctctctgagg aggaaaagga agagttaaaa 300gcagagttag ttcagctaga agacgaaatt acaacactac gacaagtttt gtcagcgaaa 360gaaaggcatc tagttgagat aaaacaaaaa ctcggcatga acctgatgaa tgaattaaaa 420cagaacttca gcaaaagctg gcatgacatg cagactacca ctgcctacaa gaaaacacat 480gaaaccctga gtcacgcagg gcaaaaggca actgcagctt tcagcaacgt tggaacggcc 540atcagcaaga agttcggaga catgagttac tccattcgcc attccataag tatgcctgct 600atgaggaatt ctcctacttt caaatcattt gaggagaggg ttgagacaac tgtcacaagc 660ctcaagacga aagtaggcgg tacgaaccct aatggaggca gttttgagga ggtcctcagc 720tccacggccc atgccagtgc ccagagcttg gcaggaggct cccggcggac caaggaggag 780gagctgcagt gctaagtcca gccagcgtgc agctgcatcc agaaaccggc cactacccag 840cccatctctg cctgtgctta tccagataag aagaccaaaa tcccgctggg aaaaacccag 900gccttgacat tgttattcaa atggcccctc cagaaagttt aatgatttcc atttgtattt 960gtgttgatga tggaccactt gaccatcaca tttcagtatt catagatgac tgtcacattt 1020taaaatgttc ccacttgagc aggtacacaa ctggtcataa ttcctgtctg tgtaattcga 1080tgtatatttt tccaaacatg tagctattgt ttgctttgat ttttgcttgg cctcctttat 1140gatgtgcatg tccttgaagg ctgaatgaac agtccctttc agttcagcag atcaacagga 1200tggagctctt catgactgtc tccagcaata ggatgattta ctataaattt catccaacta 1260cttgtgatct ctctcaccta catcaattat gtatgttaat ttcagcaatt aaaagaattg 1320atttt 1325 50 1216 DNA Homo sapiens 50ccacgagtga gccttgaacg cctggacctg gacctcacag ctgacagcca gccacccgtc 60ttcaaggtct tcccaggcag taccactgag gactacaacc ttattgttat tgaacgtggc 120gctgccgctg cagctaccgg ccagccaggg actgcgcctg caggaacccc tggtgcccca 180cccctggctg gcatggccat tgtcaaggag gaggagacgg aggctgccat tggagcccct 240cctactgcca ctgagggccc tgagaccaaa cctgtgctta tggctcttgc ggagggtcct 300ggtgctgagg gtccccgcct ggcctcacct agtggcagca ccagctcagg gctggaggtg 360gtggctcctg agggtacctc agccccaggt ggtggcccgg gaaccctgga tgacagtgcc 420accatttgcc gtgtctgcca gaagccaggc gatctggtta tgtgcaacca gtgtgagttt 480tgtttccacc tggactgtca cctgccggcc ctgcaggatg taccagggga ggagtggagc 540tgctcactct gccatgtgct ccctgacctg aaggaggagg atggcagcct cagcctggat 600ggtgcagaca gcactggcgt ggtggccaag ctctcaccag ccaaccagcg gaaatgtgag 660cgtgtactgc tggccctatt ctgtcacgaa ccctgccgcc ccctgcatca gctggctacc 720gactccacct tctccctgga ccagcccggt ggcaccctgg atctgaccct gatccgtgcc 780cgcctccagg agaagttgtc acctccctac agctccccac aggagtttgc ccaggatgtg 840ggccgcatgt tcaagcaatt caacaagtta actgaggaca aggcagacgt gcagtccatc 900atcggcctgc agcgcttctt cgagacgcgc atgaacgagg ccttcggtga caccaagttc 960tctgctgtgc tggtggagcc cccgccgatg agcctgcctg gtgctggcct gagttcccag 1020gagctgtctg gtggccctgg tgatggcccc tgaggctgga gcccccatgg ccagcccagc 1080ctggctctgt tctctgtcct gtcaccccat ccccactccc ctggtggcct gactcccact 1140ccctggtggc cccatccccc agttcctcac gatatggttt ttacttctgt ggatttaata 1200aaaacttcac cagtta 1216 51 3826 DNA Homo sapiens 51gaattcgggt ggagtcctga aggagggcct gatgtcttca tcattctcaa attcttgtaa 60gctctgcgtc gggtgaaacc agacaaagcc gcgagcccag ggatgggagc acgcggggga 120cggcctgccg gcggggacga cagcattgcg cctgggtgca gcagtgtgcg tctcggggaa 180gggaagatat tttaaggcgt gtctgagcag acggggaggc ttttccaaac ccaggcagct 240tcgtggcgtg tgcggtttcg acccggtcac acaaagcttc agcatgtcat gtgaggacgg 300tcgggccctg aaaggaacgc tctcggaatt ggccgcggaa accgatctgc ccgttgtgtt 360tgtgaaacag agaaagatag gcggccatgg tccaaccttg aaggcttatc aggagggcag 420acttcaaaag ctactaaaaa tgaacggccc tgaagatctt cccaagtcct atgactatga 480ccttatcatc attggaggtg gctcaggagg tctggcagct gctaaggagg cagcccaata 540tggcaagaag gtgatggtcc tggactttgt cactcccacc cctcttggaa ctagatgggg 600tcttggagga acatgtgtga atgtgggttg catacctaaa aaactgatgc atcaagcagc 660tttgttagga caagccctgc aagactctcg aaattatgga tggaaagtcg aggagacagt 720taagcatgat tgggacagaa tgatagaagc tgtacagaat cacattggct ctttgaattg 780gggctaccga gtagctctgc gggagaaaaa agtcgtctat gagaatgctt atgggcaatt 840tattggtcct cacaggatta aggcaacaaa taataaaggc aaagaaaaaa tttattcagc 900agagagtttt ctcattgcca ctggtgaaag accacgttac ttgggcatcc ctggtgacaa 960agaatactgc atcagcagtg atgatctttt ctccttgcct tactgcccgg gtaagaccct 1020ggttgttgga gcatcctatg tcgctttgga gtgcgctgga tttcttgctg gtattggttt 1080aggcgtcact gttatggtta ggtccattct tcttagagga tttgaccagg acatggccaa 1140caaaattggt gaacacatgg aagaacatgg catcaagttt ataagacagt tcgtaccaat 1200taaagttgaa caaattgaag cagggacacc aggccgactc agagtagtag ctcagtccac 1260caatagtgag gaaatcattg aaggagaata taatacggtg atgctggcaa taggaagaga 1320tgcttgcaca agaaaaattg gcttagaaac cgtaggggtg aagataaatg aaaagactgg 1380aaaaatacct gtcacagatg aagaacagac caatgtgcct tacatctatg ccattggcga 1440tatattggag gataaggtgg agctcacccc agttgcaatc caggcaggaa gattgctggc 1500tcagaggctc tatgcaggtt ccactgtcaa gtgtgactat gaaaatgttc caaccactgt 1560atttactcct ttggaatatg gtgcttgtgg cctttctgag gagaaagctg tggagaagtt 1620tggggaagaa aatattgagg tttaccatag ttacttttgg ccattggaat ggacgattcc 1680gtcaagagat aacaacaaat gttatgcaaa aataatctgt aatactaaag acaatgaacg 1740tgttgtgggc tttcacgtac tgggtccaaa tgctggagaa gttacacaag gctttgcagc 1800tgcgctcaaa tgtggactga ccaaaaagca gctggacagc acaattggaa tccaccctgt 1860ctgtgcagag gtattcacaa cattgtctgt gaccaagcgc tctggggcaa gcatcctcca 1920ggctggctgc tgaggttaag ccccagtgtg gatgctgttg ccaagactgc aaaccactgg 1980ctcgtttccg tgcccaaatc caaggcgaag ttttctagag ggttcttggg ctcttggcac 2040ctgcgtgtcc tgtgcttacc accgcccaag gcccccttgg atctcttgga taggagttgg 2100tgaatagaag gcaggcagca tcacactggg gtcactgaca gacttgaagc tgacatttgg 2160cagggcatcg aagggatgca tccatgaagt caccagtctc aagcccatgt ggtaggcggt 2220gatggaacaa ctgtcaaatc agttttagca tgacctttcc ttgtggattt tcttattctc 2280gttgtcaagt tttctagggt tgaatttttt tcttttttct ccatggtgtt aatgatatta 2340gagatgaaaa acgttagcag ttgatttttg tccaaaagca agtcatggct agagtatcca 2400tgcaaggtgt cttgttgcat ggaagggata gtttggctcc cttggaggct atgtaggctt 2460gtcccgggaa agagaactgt cctgcagctg aaatggactg ttctttactg acctgctcag 2520cagtttcttc tctcatatat tcccaaaaca agtacatctg cgatcaactc tagccaaatt 2580tgcccctgtg tgctacatga tggatgatta ttattttaag gtctgtttag gaagggaaat 2640ggctacttgg ccagccattg cctggcattt ggtagtatag tatgattctc accattattt 2700gtcatggagg cagacataca ccagaaatgg gggagaaaca gtacatatct ttctgtcttt 2760agtttattgt gtgctggtct aagcaagctg agatcatttg caatggaaaa cacgtaactt 2820gtttaaaagt ttttctggta gctttagctt tatgctaaaa aaaataatga cattgggtat 2880ctatttcttt ctaagacata cattagtagg aaaataagtc ttttcatgct tatgatttag 2940ctgttttgtg gtaattgctt tttaaaggaa gttattaata tcataagtta ttattaatat 3000tttgaacaca ggtggatgtg aaggattttc atttaaaaac caagtggttt tgactttttc 3060tgttgaatga acaactgtgc cttgtggaat ttttgcagaa gtgtttatgc tttgttagca 3120tttcaacttg cattattata aagaggtatt aatgcctcag ttatgtgttt gtcaatgtac 3180tggctgagga ttctatctca gctgtctttt ctaactgtgt aggttgagtt ttgaacacgt 3240gcttgtggac atcagcctcc tgccagcagt tcttgaagct tctttttcat tcctgctact 3300ctacctgtat ttctcagttg cagcactgag tggtcaaaat acatttctgg gccacctcag 3360ggaacccatg catctgcctg gcatttaggc agcagagccc ctgaccgtcc cccacaggct 3420ctgcctcacg tcctcatctc atttggctgt gtaaagaaat gggaaaaggg aaaaggagag 3480agcaattgag gcagttgacc atattcagtt ttatttattt atttttaatt tgtttttttc 3540tccaagtcca ccagtctctg aaattagaac agtaggcggt atgagataat caggcctaat 3600catgttgtga ttctcttttc ttagtggagt ggaatgttct atccccacaa gaaggattat 3660atcttataga cttgtcttgt tcagattctg tatttaccca ttttattgaa acatatacta 3720agttccatgt atttttgtta caaatcttct gaaaaaaaac aaaacaatgt gaaacattaa 3780aattaaaagg cattaataat aaaaaaaaaa aaaaaaaccc gaattc 3826 52 1959 DNA Homo sapiens 52cgaaaaaaga ggggaagagt attaaagacc atttctggct gggcagggca ctctcagcag 60ctcaactgcc cagcgtgacc agtggccacc tctgcagtgt cttccacaac ctggtcttga 120ctcgtctgct gaacaaatcc tctgacctca ggccggctgt gaacgtagtt cctgagagat 180agcaaacatg cccaacagtg agcccgcatc tctgctggag ctgttcaaca gcatcgccac 240acaaggggag ctcgtaaggt ccctcaaagc gggaaatgcg tcaaaggatg aaattgattc 300tgcagtaaag atgttggtgt cattaaaaat gagctacaaa gctgccgcgg gggaggatta 360caaggctgac tgtcctccag ggaacccagc acctaccagt aatcatggcc cagatgccac 420agaagctgaa gaggattttg tggacccatg gacagtacag acaagcagtg caaaaggcat 480agactacgat aagctcattg ttcggtttgg aagtagtaaa attgacaaag agctaataaa 540ccgaatagag agagccaccg gccaaagacc acaccacttc ctgcgcagag gcatcttctt 600ctcacacaga gatatgaatc aggttcttga tgcctatgaa aataagaagc cattttatct 660gtacacgggc cggggcccct cttctgaagc aatgcatgta ggtcacctca ttccatttat 720tttcacaaag tggctccagg atgtatttaa cgtgcccttg gtcatccaga tgacggatga 780cgagaagtat ctgtggaagg acctgaccct ggaccaggcc tatggcgatg ctgttgagaa 840tgccaaggac atcatcgcct gtggctttga catcaacaag actttcatat tctctgacct 900ggactacatg gggatgagct caggtttcta caaaaatgtg gtgaagattc aaaagcatgt 960taccttcaac caagtgaaag gcattttcgg cttcactgac agcgactgca ttgggaagat 1020cagttttcct gccatccagg ctgctccctc cttcagcaac tcattcccac agatcttccg 1080agacaggacg gatatccagt gccttatccc atgtgccatt gaccaggatc cttactttag 1140aatgacaagg gacgtcgccc ccaggatcgg ctatcctaaa ccagccctgt tgcactccac 1200cttcttccca gccctgcagg gcgcccagac caaaatgagt gccagcgacc caaactcctc 1260catcttcctc accgacacgg ccaagcagat caaaaccaag gtcaataagc atgcgttttc 1320tggagggaga gacaccatcg aggagcacag gcagtttggg ggcaactgtg atgtggacgt 1380gtctttcatg tacctgacct tcttcctcga ggacgacgac aagctcgagc agatcaggaa 1440ggattacacc agcggagcca tgctcaccgg tgagctcaag aaggcactca tagaggttct 1500gcagcccttg atcgcagagc accaggcccg gcgcaaggag gtcacggatg agatagtgaa 1560agagttcatg actccccgga agctgtcctt cgactttcag tagcactcgt tttacatatg 1620cttataaaag aagtgatgta tcagtaatgt atcaataatc ccagcccagt caaagcaccg 1680ccacctgtag gcttctgtct catggtaatt actgggcctg gcctctgtaa gcctgtgtat 1740gttatcaata ctgtttcttc ctgtgagttc cattatttct atctcttatg ggcaaagcat 1800tgtgggtaat tggtgctggc taacattgca tggtcggata gagaagtcca gctgtgagtc 1860tctccccaaa gcagccccac agtggagcct tcggctggaa gtccatgggc caccctgttc 1920ttgtccatgg aggacttccg agggttccaa gtatactct 1959 53 1826 DNA Homo sapiens 53cacgtcggct gctgggaaga tctggattct cgtttcaggt caccatcaga aaagctaagt 60ttgctgtata gtgaggatca ggagatctga tcctgattgc agaaccttcc ctgattacag 120aatcttggat gatttcacaa aagttcatct tcattgcaga tacctgcctt tctttctagg 180ttgtatctcc cacttcaccc ttctagacca tcccagaaga tctataagat ttcatctggg 240aaatcactag gagttcttgg aagggaaaga aggaagattg ttggttggaa taaaaacagg 300gttgaatgag ttccagaaag cagggttctc aacctcgtgg acagcaatct gcagaagaag 360agaacttcaa aaaaccaact agaagcaaca tgcagagaag taaaatgaga ggggcctcct 420caggaaagaa gacagctggt ccacagcaga aaaatcttga accagctctc ccaggaagat 480ggggtggtcg ctctgcagag aacccccctt caggatccgt gaggaagacc agaaagaaca 540agcagaagac tcctggaaac ggagatggtg gcagtaccag cgaagcacct cagccccctc 600ggaagaaaag ggcccgggca gaccccactg ttgaaagtga ggaggcgttt aagaatagaa 660tggaggttaa agtgaagatt cctgaagaat taaaaccatg gcttgttgag gactgggact 720tagttaccag gcagaagcag ctgtttcaac tccctgccaa gaaaaatgta gatgcaattc 780tggaggagta tgcaaattgc aagaaatcgc agggaaatgt tgataataag gaatatgcgg 840ttaatgaagt tgtggcagga ataaaagaat atttcaatgt gatgttgggc actcagctgc 900tctacaaatt tgagaggccc cagtatgctg aaatcctctt ggctcaccct gatgctccaa 960tgtcccaggt ttatggagca ccacacctac tgagattatt tgtaagaatt ggagcaatgt 1020tggcctatac gccccttgat gagaaaagcc ttgcattatt gttgggctat ttgcatgatt 1080tcctaaaata tctggcaaag aattctgcat ctctctttac tgccagtgat tacaaagtgg 1140cttctgctga gtaccaccgc aaagccctgt gagcgtctac agacagctca ccatttttgt 1200cctgtatctg taaacacttt ttgttcttag tctttttctt gtaaaattga tgttctttaa 1260aatcgttaat gtataacagg gcttatgttt cagtttgttt tccgttctgt tttaaacaga 1320aaataaaagg agtgtaagct ccttttctca tttcaaagtt gctaccagtg tatgcagtaa 1380ttagaacaaa gaagaaacat tcagtagaac attttattgc ctagttgaca acattgcttg 1440aatgctggtg gttcctatcc ctttgacact acacaatttt ctaatatgtg ttaatgctat 1500gtgacaaaac gccctgattc ctagtgccaa aggttcaact taatgtatat acctgaaaac 1560ccatgcattt gtgctctttt tttttttatg gtgcttgaag taaaacagcc catcctctgc 1620aagtccatct atgttgttct taggcattct atctttgctc aaattgttga aggatggtga 1680tttgtttcat ggtttttgta tttgagtcta atgcacgttc taacatgata gaggcaatgc 1740attattgtgt agccacggtt ttctggaaaa gttgatattt taggaattgt atttcagatc 1800ttaaataaaa tttgtttcta aatttc 1826 54 1822 DNA Homo sapiens 54ttgagccacc atctgaccgc aagctgcgtc gtgtcgccgg ttctgcaggc accatgagcc 60aggacaccga ggtggatatg aaggaggtgg agctgaatga gttagagccc gagaagcagc 120cgatgaacgc ggcgtctggg gcggccatgt ccctggcggg agccgagaag aatggtctgg 180tgaagatcaa ggtggcggaa gacgaggcgg aggcggcagc gccggctaag ttcacgggcc 240tgtccaagga ggagctgctg aaggtggcag gcagccccgg ctgggtacgc acccgctggg 300cactgctgct gctcttctgg ctcggctggc tcggcatgct tgctggtgcc gtggtcataa 360tcgtgcgagc gccgcgttgt cgcgagctac cggcgcagaa gtggtggcac acgggcgccc 420tctaccgcat cggcgacctt caggccttcc agggccacgg cgcgggcaac ctggcgggtc 480tgaaggggcg tctcgattac ctgagctctc tgaaggtgaa gggccttgtg ctgggtccaa 540ttcacaagaa ccagaaggat gatgtcgctc agactgactt gctgcagatc gaccccaatt 600ttggctccaa ggaagatttt gacagtctct tgcaatcggc taaaaaaaag agcatccgtg 660tcattctgga ccttactccc aactaccggg gtgagaactc gtggttctcc actcaggttg 720acactgtggc caccaaggtg aaggatgctc tggagttttg gctgcaagct ggcgtggatg 780ggttccaggt tcgggacata gagaatctga aggatgcatc ctcattcttg gctgagtggc 840aaaatatcac caagggcttc agtgaagaca ggctcttgat tgcggggact aactcctccg 900accttcagca gatcctgagc ctactcgaat ccaacaaaga cttgctgttg actagctcat 960acctgtctga ttctggttct actggggagc atacaaaatc cctagtcaca cagtatttga 1020atgccactgg caatcgctgg tgcagctgga gtttgtctca ggcaaggctc ctgacttcct 1080tcttgccggc tcaacttctc cgactctacc agctgatgct cttcaccctg ccagggaccc 1140ctgttttcag ctacggggat gagattggcc tggatgcagc tgcccttcct ggacagccta 1200tggaggctcc agtcatgctg tgggatgagt ccagcttccc tgacatccca ggggctgtaa 1260gtgccaacat gactgtgaag ggccagagtg aagaccctgg ctccctcctt tccttgttcc 1320ggcggctgag tgaccagcgg agtaaggagc gctccctact gcatggggac ttccacgcgt 1380tctccgctgg gcctggactc ttctcctata tccgccactg ggaccagaat gagcgttttc 1440tggtagtgct taactttggg gatgtgggcc tctcggctgg actgcaggcc tccgacctgc 1500ctgccagcgc cagcctgcca gccaaggctg acctcctgct cagcacccag ccaggccgtg 1560aggagggctc ccctcttgag ctggaacgcc tgaaactgga gcctcacgaa gggctgctgc 1620tccgcttccc ctacgcggcc tgacttcagc ctgacatgga cccactaccc ttctcctttc 1680cttcccaggc cctttggctt ctgatttttc tcttttttaa aaacaaacaa acaaactgtt 1740gcagattatg agtgaacccc caaatagggt gttttctgcc ttcaaataaa agtcacccct 1800gcatggtgaa gtcttccctc tg 1822 55 1992 DNA Homo sapiens 55aaacttcccg cacgcgttac aggagccagg tcggtataag cgccacgcct cgccgcccgt 60caagctgtcc acatccctgg cctcagcccg ccacatcacc ctgacctgct tacgcccaga 120ttttcttcaa tcacatctga ataaatcact tgaagaaagc ttatagcttc attgcaccat 180gtgtggcatt tgggcgctgt ttggcagtga tgattgcctt tctgttcagt gtctgagtgc 240tatgaagatt gcacacagag gtccagatgc attccgtttt gagaatgtca atggatacac 300caactgctgc tttggatttc accggttggc ggtagttgac ccgctgtttg gaatgcagcc 360aattcgagtg aagaaatatc cgtatttgtg gctctgttac aatggtgaaa tctacaacca 420taagaagatg caacagcatt ttgaatttga ataccagacc aaagtggatg gtgagataat 480ccttcatctt tatgacaaag gaggaattga gcaaacaatt tgtatgttgg atggtgtgtt 540tgcatttgtt ttactggata ctgccaataa gaaagtgttc ctgggtagag atacatatgg 600agtcagacct ttgtttaaag caatgacaga agatggattt ttggctgtat gttcagaagc 660taaaggtctt gttacattga agcactccgc gactcccttt ttaaaagtgg agccttttct 720tcctggacac tatgaagttt tggatttaaa gccaaatggc aaagttgcat ccgtggaaat 780ggttaaatat catcactgtc gggatgtacc cctgcacgcc ctctatgaca atgtggagaa 840actctttcca ggttttgaga tagaaactgt gaagaacaac ctcaggatcc tttttaataa 900tgctgtaaag aaacgtttga tgacagacag aaggattggc tgccttttat cagggggctt 960ggactccagc ttggttgctg ccactctgtt gaagcagctg aaagaagccc aagtacagta 1020tcctctccag acatttgcaa ttggcatgga agacagcccc gatttactgg ctgctagaaa 1080ggtggcagat catattggaa gtgaacatta tgaagtcctt tttaactctg aggaaggcat 1140tcaggctctg gatgaagtca tattttcctt ggaaacttat gacattacaa cagttcgtgc 1200ttcagtaggt atgtatttaa tttccaagta tattcggaag aacacagata gcgtggtgat 1260cttctctgga gaaggatcag atgaacttac gcagggttac atatattttc acaaggctcc 1320ttctcctgaa aaagccgagg aggagagtga gaggcttctg agggaactct atttgtttga 1380tgttctccgc gcagatcgaa ctactgctgc ccatggtctt gaactgagag tcccatttct 1440agatcatcga tttttttcct attacttgtc tctgccacca gaaatgagaa ttccaaagaa 1500tgggatagaa aaacatctcc tgagagagac gtttgaggat tccaatctga tacccaaaga 1560gattctctgg cgaccaaaag aagccttcag tgatggaata acttcagtta agaattcctg 1620gtttaagatt ttacaggaat acgttgaaca tcaggttgat gatgcaatga tggcaaatgc 1680agcccagaaa tttcccttca atactcctaa aaccaaagaa ggatattact accgtcaagt 1740ctttgaacgc cattacccag gccgggctga ctggctgagc cattactgga tgcccaagtg 1800gatcaatgcc actgaccctt ctgcccgcac gctgacccac tacaagtcag ctgtcaaagc 1860ttaggtggtc tttatgctgt aatgtgaaag caaatatttc ttcgtgttgg atggggactg 1920tgggtagata ggggaacaat gagagtcaac tcaggctaac ttgggtttga aaaaaataaa 1980attcctaaat tt 1992 56 4086 DNA Homo sapiens 56cgcgacctcg tggtgggctg cggtggcttc gtcaagtcgg acgtggagat caactactct 60ctcatcgaga taaagctgta caccaagcat gggactttga aataccagac agactgtgcc 120cctaataatg gttactttat gatccctttg tatgataagg gggatttcat tctgaagatt 180gagcctcccc tagggtggag ttttgagccg acgaccgtgg agctccatgt ggatggagtc 240agtgacatct gcacaaaggg tggggacatc aactttgtct tcactgggtt ctctgtgaat 300ggcaaggtcc tcagcaaagg gcagcccctg ggtcctgcgg gagttcaggt gtctctgaga 360aacactggga ccgaagcaaa gatccagtcc acagttacac agcctggcgg aaagtttgca 420ttttttaaag ttctgcctgg agattatgaa atcctcgcaa ctcatccaac ctgggcgttg 480aaagaggcaa gcaccacagt gagtgtaacc aactccaatg ccaatgcggc cagtcccctc 540atagttgctg gctacaatgt gtctggctct gtccgaagtg atggggagcc catgaaaggc 600gtgaagtttc ttctcttttc ttctttagta actaaagagg atgtcctggg ctgcaatgtc 660tcaccagtgc ctgggttcca gccccaagac gagagtctgg tgtatttgtg ctacacggtc 720tccagagaag atggctcgtt ctctttctat tccttgccaa gtgggggcta cactgtgatt 780ccgttctatc gaggggagag gattaccttt gatgtggcgc cttccagact tgacttcaca 840gtggagcatg acagcttgaa aatcgagccc gtgttccacg tcatgggatt ctccgtcacc 900gggagggtct tgaacggacc cgaaggagat ggtgttccag aagcagtagt caccctgaat 960aaccaaatca aagttaaaac aaaagctgat ggctcattcc gccttgagaa cataaccaca 1020gggacataca ccatccatgc tcagaaagag cacctctact ttgaaacggt caccatcaaa 1080attgcaccga acacacctca gctggctgac attattgcaa cagggttcag tgtctgtggt 1140cagatatcaa tcattcgctt ccccgacacc gtcaagcaga tgaataaata caaagttgtc 1200ctgtcatctc aagacaagga caagtctttg gtcaccgtgg agacagatgc tcatggatca 1260ttttgtttta aagcaaaacc agggacttac aaagtgcagg tgatggttcc tgaggcagaa 1320accagagcag ggctgacgtt gaaaccccag acatttcctc ttactgtgac caacaggccc 1380atgatggatg tggcctttgt acagttcttg gcatcagttt ctgggaaagt ctcttgcttg 1440aacacctgtg gtgacttgct ggtgactcta cagtccctga gccgccaggg tgagaagcgg 1500agcctccagc tctccggcaa ggtcaacgcc atgactttca cctttgacaa cgtgctccct 1560ggaaaataca aaataagcat catgcatgag gattggtgct ggaagaacaa gagcctggag 1620gtggaagtgc tggaggatga catgtctgca gttgagttca ggcagacggg ctacatgctg 1680agatgttccc tgtctcacgc catcactctg gaattttatc aggatggaaa tgggcgtgag 1740aatgtgggga tttatagcct cttcaaagga gtcaaccgat tctgcctgtc caagcctggt 1800gtgtacaaag tgacccctcg ctcctgccac cggtttgagc aagcgttcta tatctatgac 1860acgtcttcac ctagtatctt tacattgaca gccattcgcc accatgtcct tggaactatc 1920accaccgaca aaatgatgga tgtcactgtg actatcaagt cttccatcga cagtgaaccc 1980gccttggtct taggccctct gaagtctgtg caggagctgc ggagggagca gcagctggct 2040gagatcgagg cccgcaggca ggagagggag aaaaacggca atgaggaagg cgaagaaaga 2100atgaccaagc ctcccgtgca ggagatggta gatgagttac aaggcccctt ctcgtatgat 2160ttctcttact gggcgcggtc tggagagaaa atcactgtta caccgtcatc taaagagctg 2220ctcttttatc ccccttcaat ggaagccgtt gtcagtggag aaagctgccc agggaagctg 2280atcgagatcc atgggaaggc aggcctgttt ttagaaggcc agatccaccc cgagttggaa 2340ggagtcgaga ttgtcatcag tgaaaagggg gcaagttcac cgctgatcac agtctttact 2400gatgacaaag gtgcctacag tgttggcccc ctgcacagtg acctggagta cacggtgacc 2460tcacagaagg agggctatgt tctgactgcg gtggaaggaa ccatcggaga cttcaaggcc 2520tatgccctgg caggcgtaag ctttgagata aaagctgagg atgaccagcc cctcccggga 2580gtcctcttat ccctgagcgg tggcctgttt cgttccaacc tcttgaccca ggacaacggc 2640attctgacat tctcaaacct gagccctggc cagtattact tcaaacccat gatgaaggag 2700ttccggtttg agccatcctc acagatgatc gaggtgcagg aaggccagaa cctgaagatc 2760accatcacgg ggtaccgaac cgcttacagt tgctatggca cagtgtcttc cttaaacgga 2820gagcccgaac aaggggttgc catggaagcg gtgggccaga acgactgcag catttacgga 2880gaagacaccg tgacagacga agagggcaag ttcagattac gtggattgct gccgggatgt 2940gtgtaccacg ttcagctcaa ggcagaaggc aacgaccaca ttgagcgggc gctcccccac 3000catagggtga ttgaggttgg gaataatgac atcgatgatg taaacatcat agttttccgg 3060cagattaatc aatttgattt aagtggaaat gtgatcactt cctctgaata ccttcctaca 3120ttatgggtca agctttacaa aagcgaaaac ctcgacaatc caatccagac agtttccctt 3180ggccagtccc tgttcttcca tttcccccca ctgctcagag acggcgagaa ctatgttgtg 3240cttctggact ccacactccc cagatcccag tatgactaca tcttgcctca agtttctttc 3300accgcagtgg gctaccataa acacaccacc ttgattttta atcccacgag gaagctgcct 3360gaacaggaca tcgcacaagg atcctacatt gccctgccat tgacgctgct ggttctgctg 3420gccggttaca accatgacaa gctcattcct ttgctgctgc agttgacaag ccggctacag 3480ggagtccgcg cgctcggcca ggcagcctct gacaatagcg gcccagaaga tgcaaagaga 3540caagccaaga aacagaagac aaggcggact tgaggaggaa ggggacagtt gcagtctcac 3600ttgggacagg ccacagccag gggtccggcc actacccgcc cgtgggataa aagccaaaag 3660catgcgtcag ctaacttcag cctgtgctgc tgggcccgca ccccatgtcc cttgtcactg 3720tgacatcctg cacccatcct cacccctccg tagagcccct cgtgcaatgc aatgaatgga 3780ccctcctgtc actctgctga acagaattta ttttctgagt caaatataat ttattattat 3840tttcgtcaaa gaagtattta agctgtgctg tggtgtgaga atgtcattct tgatcttcag 3900ccttcgtttg caaggagagt tccagttgac gtggtgtttg gttccatggc ggggtaccct 3960ggggattcat ctgttttctt cacttccctt tgcatctgag atcctgttgg aaaccacagc 4020aacctgtatt cattattagg aaataaaaat cgaaaaaaag gttcattctt ttgtgttgta 4080gttttg 4086 57 3701 DNA Homo sapiens 57cggaaatcat cctagtaata aagtgaaatc agacccacaa cgaatgaatg aacagccacg 60tcagcttttc caaagctcat gaacactgga aaacaacata cgtttgttga aacagagagt 120gtaagatatg tctaccagcc tatggagaaa ctgtatatgg tactgatcac taccaaaaac 180agcaacattt tagaagattt ggagacccta aggctcttct caagagtgat ccctgaatat 240tgccgagcct tagaagagaa tgaaatatct gagcactgtt ttgatttgat ttttgctttt 300gatgaaattg tcgcactggg ataccgggag aatgttaact tggcacagat cagaaccttc 360acagaaatgg attctcatga ggagaaggtg ttcagagccg tcagagagac tcaagaacgt 420gaagctaagg ctgagatgcg tcgtaaagca aaggaattac aacaggcccg aagagatgca 480gagagacagg gcaaaaaagc accaggattt ggcggatttg gcagctctgc agtatctgga 540ggcagcacag ctgccatgat cacagagacc atcattgaaa ctgataaacc aaaagtggca 600cctgcaccag ccaggccttc aggccccagc aaggctttaa aacttggagc caaaggaaag 660gaagtagata actttgtgga caaattaaaa tctgaaggtg aaaccatcat gtcctctagt 720atgggcaagc gtacttctga agcaaccaaa atgcatgctc cacccattaa tatggaaagt 780gtacatatga agattgaaga aaagataaca ttaacctgtg gacgagacgg aggattacag 840aatatggagt tgcatggcat gatcatgctt aggatctcag atgacaacta tggccgaatt 900cgtcttcatg tggaaaatga agataagaaa ggggtgcagc tacagaccca tccaaatgtg 960gataaaaaac ttttcactgc agagtctcta attggcctga agaatccaga gaagtcattt 1020ccagtcaaca gtgacgtagg ggtgctaaag tggagactac aaaccacaga ggaatctttt 1080attccactga caattaattg ctggccctcg gagagtggaa atggctgtga tgtcaacata 1140gaatatgagc tacaagaaga taatttagaa ctgaatgatg tggttatcac catcccactc 1200ccgtctggtg tcggcgcgcc tgttatcggt gagatcgatg gggagtatcg acatgacagt 1260cgacgaaata ccctggagtg gtgcctgcct gtgattgatg ccaaaaataa gagtggcagc 1320ctggagttta gcattgctgg gcagcccaat gacttcttcc ctgttcaagt ttcctttgtc 1380tccaagaaaa attactgtaa catacaggtt accaaagtga cccaggtaga tggaaacagc 1440cccgtcaggt tttccacaga gaccactttc ctagtggata agtatgaaat tctgtaatac 1500caagaagagg gagctgaaaa ggaaaatttt cagattaata aagaagacgc caatgatggc 1560tgaagagttt ttcccagatt tacaagccac tggagacccc ttttttctga tacaatgcac 1620gattctctgc gcgcaaggac cctcgactca cccccatgtt tcagtgtcac agagacattc 1680tttgataagg aaatggcaca aacataaagg gaaaggctgc taattttctt tggcagattg 1740tattggccag caggaaagca agctctccag agaatgcccc cagttaaata cctcctctac 1800ctttacctaa gttgctcctt tatttttatt ttattattat tattattatt attatttttt 1860gagatggagt ctcactttgt aacccaggct ggaatgcaat ggcatgatct cagctcactg 1920caacctccgc ctcctgggtt caagcaagtc tcctgcctca gcctccgagt agctgggact 1980acaggtgcac gccaccacgc ctggctaatt ttttgtattt tagtagagac ggggtttcac 2040cgtgttgccc aggctggtcg cgaactcctg agctcaggca atccgcccac ctcagcctcc 2100caaagtgttg ggattacagg catgagccac catgcccagc tgctccttta ttttaatccc 2160taaatataat ccctaaatat agttatattt catacttagt ttgtttttaa aaagttttct 2220ctgtagaaaa ttttaatcat tcataccctt tacctttagg tttttctttc tatacattca 2280gtcaggcact gggatcatct gtttacaggc attatattta tttggcactc ctggaacaag 2340tatatctaac ccattcttga tttttggact attcaggtga actatttgag gggtatgggg 2400tctagaagtt aaaagatacg catgtcttct rttcttttcc cgtatcaatt cattccttca 2460tctctttgcc aagttgtttt cctttcaggg cctgtccttc cagtttagaa cagtaccatg 2520aatcccactt gtgtcaatat taaagatagc tgagaagcac ctttcaaatg gcacagtccc 2580tcttcaagat gtctaaaaga atggttatgt ctgtccagtt agggatttca catccacatg 2640taatcatgtc tgctgctgtt gctacccaaa ttttcatttc tccacatttt gggtacttaa 2700gctaaaacgt aatggccaca gtctgtaatc cattcacatt cctcagtttc accacctccc 2760tcttccagac tgcactctct gtcatcagtc ccctcctttc taacagaaat ggggttatga 2820ttttgaaggc tgtgggttca gggagtcttt gccaatcctg ttggccctaa actatcaagg 2880aggctccatt tcaccatttg attttttgca tttcaggagg caactgattg tttcgatatg 2940tacatattac tcacgtatac cccatttcct tccagtcagc ccaacatttt ccaccagtct 3000gtccccatct ctgaaatcct tccttctctt tccccctaag tcttttgagt gtcatcatgt 3060actggtggtt tctcggttcc atctcatcca tttccttttc aatggagact acagcgtcag 3120ccagctcagc cttggctttt aactcaatat tccagtccat aggggtggtt aaaagttgct 3180gcaaggctgc aggcactggc agtgggaaga ggcagacgac tagatgactt ctgcactttt 3240agctggttga aaagtaccac tcccactctg aacatctggc cgtccctgca aagagtgtac 3300tgtgcttgaa gcagagcact cacacataaa tggctgtgtg tggaattgct tgccaaagaa 3360gtttctagcc tttccctttc ccctaactgc atcagggaag aattcttatc tctagcttgg 3420tttccacatg aggtttttct gagaagggct tgggacaaga agtctgtcat gttagttaag 3480caggcaagaa atcctactaa tccagttttg tttgaaagtt gtttgtccgt atgatttttt 3540aaaagtcaag tttaatttca aaaaaccttt tttttctgag attacttttg gggtaatatt 3600taaaatgaga gacattttgt aaccctgtaa aatacatagg gaatataaca ttccagtgta 3660tacaaagaag gcaaattcca aaaaaaaaaa aaaaaaaaaa a 3701 58 6608 DNA Homo sapiens 58ccttctttta aggagtttgc cgcgagcgcg tctccttcat tcgcaggctg ggcgcgttcg 60cagtcggctg gcggcgaagg aaggcgctct cgggacctca cgggcgcgcg tcttttggct 120cttgcccctg tccctgcggc ttggggaaag cgtaacccgg cggctaggcg cgggagaagt 180gcggaggagc catgggcgcc gggagctcca ccgagcagcg cagcccggag cagccgcccg 240aggggagctc cacgccggct gagcccgagc ccagcggcgg cggcccctcg gccgaggcgg 300cgccagacac caccgcggac cccgccatcg ctgcctcgga ccccgccacc aagctcctac 360agaagaatgg tcagctgtcc accatcaatg gcgtagctga gcaagatgag ctcagcctcc 420aggagggtga cctaaatggc cagaaaggag ccctgaacgg tcaaggagcc ctaaacagcc 480aggaggaaga agaagtcatt gtcacggagg ttggacagag agactctgaa gatgtgagcg 540aaagagactc cgataaagag atggctacta agtcagcggt tgttcacgac atcacagatg 600atgggcagga ggagaaccga aatatcgaac agattccttc ttcagaaagc aatttagaag 660agctaacaca acccactgag tcccaggcta atgatattgg atttaagaag gtgtttaagt 720ttgttggctt taaattcact gtgaaaaagg ataagacaga gaagcctgac actgtccagc 780tactcactgt gaagaaagat gaaggggagg gagcagcagg ggctggcgac caccaggacc 840ccagccttgg ggctggagaa gcagcatcca aagaaagcga acccaaacaa tctacagaga 900aacccgaaga gaccctgaag cgtgagcaaa gccacgcaga aatttctccc ccagccgaat 960ctggccaagc agtggaggaa tgcaaagagg aaggagaaga gaaacaagaa aaagaaccta 1020gcaagtctgc agaatctccg actagtcccg tgaccagtga aacaggatca accttcaaaa 1080aattcttcac tcaaggttgg gccggctggc gcaaaaagac cagtttcagg aagccgaagg 1140aggatgaagt ggaagcttca gagaagaaaa aggaacaaga gccagaaaaa gtagacacag 1200aagaagacgg aaaggcagag gttgcctccg agaaactgac cgcctccgag caagcccacc 1260cacaggagcc ggcagaaagt gcccacgagc cccggttatc agctgaatat gagaaagttg 1320agctgccctc agaggagcaa gtcagtggct cgcagggacc ttctgaagag aaacctgctc 1380cgttggcgac agaagtgttt gatgagaaaa tagaagtcca ccaagaagag gttgtggccg 1440aagtccacgt cagcaccgtg gaggagagaa ccgaagagca gaaaacggag gtggaagaaa 1500cagcagggtc tgtgccagct gaagaattgg ttggaatgga tgcagaacct caggaagccg 1560aacctgccaa ggagctggtg aagctcaaag aaacgtgtgt ttccggagag gaccctacac 1620agggagctga cctcagtcct gatgagaagg tgctgtccaa accccccgaa ggcgttgtga 1680gtgaggtgga aatgctgtca tcacaggaga gaatgaaggt gcagggaagt ccactaaaga 1740agctttttac cagcactggc ttaaaaaagc tttctggaaa gaaacagaaa gggaaaagag 1800gaggaggaga cgaggaatca ggggagcaca ctcaggttcc agccgattct ccggacagcc 1860aggaggagca aaagggcgag agctctgcct catcccctga ggagcccgag gagatcacgt 1920gtctggaaaa gggcttagcc gaggtgcagc aggatgggga agctgaagaa ggagctactt 1980ccgatggaga gaaaaaaaga gaaggtgtca ctccctgggc atcattcaaa aagatggtga 2040cgcccaagaa gcgtgttaga cggccttcgg aaagtgataa agaagatgag ctggacaagg 2100tcaagagcgc taccttgtct tccaccgaga gcacagcctc tgaaatgcaa gaagaaatga 2160aagggagcgt ggaagagcca aagccggaag aaccaaagcg caaggtggat acctcagtat 2220cttgggaagc tttaatttgt gtgggatcat ccaagaaaag agcaaggaga aggtcctctt 2280ctgatgagga agggggacca aaagcaatgg gaggagacca ccagaaagct gatgaggccg 2340gaaaagacaa agagacgggg acagacggga tccttgctgg ttcccaagaa catgatccag 2400ggcagggaag ttcctccccg gagcaagctg gaagccctac cgaaggggag ggcgtttcca 2460cctgggagtc atttaaaagg ttagtcacgc caagaaaaaa atcaaagtcc aagctggaag 2520agaaaagcga agactccata gctgggtctg gtgtagaaca ttccactcca gacactgaac 2580ccggtaaaga agaatcctgg gtctcaatca agaagtttat tcctggacga aggaagaaaa 2640ggccagatgg gaaacaagaa caagcccctg ttgaagacgc agggccaaca ggggccaacg 2700aagatgactc tgatgtcccg gccgtggtcc ctctgtctga gtatgatgct gtagaaaggg 2760agaaaatgga ggcacagcaa gcccaaaaag gcgcagagca gcccgagcag aaggcagcca 2820ctgaggtgtc caaggagctc agcgagagtc aggttcatat gatggcagca gctgtcgctg 2880acgggacgag ggcagctacc attattgaag aaaggtctcc ttcttggata tctgcttcag 2940tgacagaacc tcttgaacaa gtagaagctg aagccgcact gttaactgag gaggtattgg 3000aaagagaagt aattgcagaa gaagaacccc ccacggttac tgaacctctg ccagagaaca 3060gagaggcccg gggcgacacg gtcgttagtg aggcggaatt gacccccgaa gctgtgacag 3120ctgcagaaac tgcagggcca ttgggttccg aagaaggaac cgaagcatct gctgctgaag 3180agaccacaga aatggtgtca gcagtctccc agttaaccga ctccccagac accacagagg 3240aggccactcc ggtgcaggag gtggaaggtg gcgtacctga catagaagag caagagaggc 3300ggactcaaga ggtcctccag gcagtggcag aaaaagtgaa agaggaatcc cagctgcctg 3360gcaccggtgg gccagaagat gtgcttcagc ctgtgcagag agcagaggca gaaagaccag 3420aagagcaggc tgaagcgtcg ggtctgaaga aagagacgga tgtagtgttg aaagtagatg 3480ctcaggaggc aaaaactgag ccttttacac aagggaaggt ggtggggcag accaccccag 3540aaagctttga aaaagctcct caagtcacag agagcataga gtccagtgag cttgtaacca 3600cttgtcaagc cgaaacctta gctggggtaa aatcacagga gatggtgatg gaacaggcta 3660tcccccctga ctcggtggaa acccctacag acagtgagac tgatggaagc acccccgtag 3720ccgactttga cgcaccaggc acaacccaga aagacgagat tgtggaaatc catgaggaga 3780atgaggtcgc atctggtacc cagtcagggg gcacagaagc agaggcagtt cctgcacaga 3840aagagaggcc tccagcacct tccagttttg tgttccagga agaaactaaa gaacaatcaa 3900agatggaaga cactctagag catacagata aagaggtgtc agtggaaact gtatccattc 3960tgtcaaagac tgaggggact caagaggctg accagtatgc tgatgagaaa accaaagacg 4020taccattttt cgaaggactt gaggggtcta tagacacagg cataacagtc agtcgggaaa 4080aggtcactga agttgccctt aaaggtgaag ggacagaaga agctgaatgt aaaaaggatg 4140atgctcttga actgcagagt cacgctaagt ctcctccatc ccccgtggag agagagatgg 4200tagttcaagt cgaaagggag aaaacagaag cagagccaac ccatgtgaat gaagagaagc 4260ttgagcacga aacagctgtt accgtatctg aagaggtcag taagcagctc ctccagacag 4320tgaatgtgcc catcatagat ggggcaaagg aagtcagcag tttggaagga agccctcctc 4380cctgcctagg tcaagaggag gcagtatgca ccaaaattca agttcagagc tctgaggcat 4440cattcactct aacagcggct gcagaggagg aaaaggtctt aggagaaact gccaacattt 4500tagaaacagg tgaaacgttg gagcctgcag gtgcacattt agttctggaa gagaaatcct 4560ctgaaaaaaa tgaagacttt gccgctcatc caggggaaga tgctgtgccc acagggcccg 4620actgtcaggc aaaatcgaca ccagtgatag tatctgctac taccaagaaa ggcttaagtt 4680ccgacctgga aggagagaaa accacatcac tgaagtggaa gtcagatgaa gtcgatgagc 4740aggttgcttg ccaggaggtc aaagtgagtg tagcaattga ggatttagag cctgaaaatg 4800ggattttgga acttgagacc aaaagcagta aacttgtcca aaacatcatc cagacagccg 4860ttgaccagtt tgtacgtaca gaagaaacag ccaccgaaat gttgacgtct gagttacaga 4920cacaagctca cgtgataaaa gctgacagcc aggacgctgg acaggaaacg gagaaagaag 4980gagaggaacc tcaggcctct gcacaggatg aaacaccaat tacttcagcc aaagaggagt 5040cagagtcaac cgcagtggga caagcacatt ctgatatttc caaagacatg agtgaagcct 5100cagaaaagac catgactgtt gaggtagaag gttccactgt aaatgatcag cagctggaag 5160aggtcgtcct cccatctgag gaagagggag gtggagctgg aacaaagtct gtgccagaag 5220atgatggtca tgccttgtta gcagaaagaa tagagaagtc actagttgaa ccgaaagaag 5280atgaaaaagg tgatgatgtt gatgaccctg aaaaccagaa ctcagccctg gctgatactg 5340atgcctcagg aggcttaacc aaagagtccc cagatacaaa tggaccaaaa caaaaagaga 5400aggaggatgc ccaggaagta gaattgcagg aaggaaaagt gcacagtgaa tcagataaag 5460cgatcacacc ccaagcacag gaggagttac agaaacaaga gagagaatct gcaaagtcag 5520aacttacaga atcttaaaac atcatgcagt taaactcatt gtctgtttgg aagaccagaa 5580tgtgaagaca agtagtagaa gaaaatgaat gctgctgctg agactgaaga ccagtatttc 5640agaactttga gaattggaga gcaggcacat caactgatct catttctaga gagcccctga 5700caatcctgag gcttcatcag gagctagagc catttaacat ttcctctttc caagaccaac 5760ctacaatttt cccttgataa ccatataaat tctgatttaa ggtcctaaat tcttaacctg 5820gaactggagt tggcaatacc tagttctgct tctgaaactg gagtatcatt ctttacatat 5880ttatatgtat gttttaagta gtcctcctgt atctattgta tatttttttc ttaatgttta 5940aggaaatgtg caggatacta catgcttttt gtatcacaca gtatatgatg gggcatgtgc 6000catagtgcag gcttggggag ctttaagcct cagttatata acccacaaaa aacagagcct 6060cctagatgta acattcctga tcaaggtaca attctttaaa attcactaat gattgaggtc 6120catatttagt ggtactctga aattggtcac tttcctatta cacggagtgt gccaaaacta 6180aaaagcattt tgaaacatac agaatgttct attgtcattg ggaaattttg ctttctaacc 6240cagtggaggt tagaaagaag ttatattctg gtagcaaatt aactttacat cctttttcct 6300acttgttatg gttgtttgga ccgataagtg tgcttaatcc tgaggcaaag tagtgaatat 6360gttttatatg ttatgaagaa aagaattgtt gtaagttttt gattctactc ttatatgctg 6420gactgcattc acacatggca tgaaataagt caggttcttt acaaatggta ttttgataga 6480tactggattg tgtttgtgcc atatttgtgc cattccttta agaacaatgt tgcaacacat 6540tcatttggat aagttgtgat ttgacgactg atttaaataa aatatttgct tcacttaaaa 6600aaaaaaaa 6608 59 1703 DNA Homo sapiens 59aagcttgtgg cttcttctcc ttactcttcc tccttggtgt ctctatgtta gagggccgtt 60agcatctgct ggggcctggt cgcattcacc ctgctctgcc actcactggc tgtgtgactc 120tggacaaatt aacttctctg gacctggcag tttctcctct ctacaatgag aatactggag 180agtccttatc ttatgggttg ctacagaatt aagtgacatc tcacacacaa cacacttcct 240acagtccctg ttacacgcta aaagtactca actagcttcg gatacgtcat cagcaaccac 300cccacgggtt actgtgatgc tgcacaatta ttaagccctg gctgctacag agttgtaacc 360tgtctgcact tccaaccggc gccgcaagca gcattcccag tcccgctttc acccgcgcgc 420taacggctca ggttcgagta caggacagga gggaggggag ctgtgcacac ggcggaggcg 480cacggcgtgg gcacccagca cccggtacac tgtgtcctcc cgctgcaccc agccccttca 540gcccgaggcg tccccgaggc gcaagtgggc cgccttcagg gaactgaccg cccgcggccc 600gtgtgcagag ccgggtgcgc ccggcccagt gcgcgcggcc gggtgtttcg cttggagccg 660caagtgactt ctagcgcggg gcgtgtgcag gcacggccgg ggcggggctt ttgcactcgt 720cccggctctt tctagctata aacactgctt gccgcgctgc actccaccac gcctcctcca 780agtcccagcg aacccgcgtg caacctgtcc cgactctagc cgcctcttca gcacgccatg 840gatcccaact gctcctgcgc cgccggtaag aggctgggga tgcccagtgt agactgtagc 900gctagagaag caatttctga cccctctttc tttctctggt cactcaattt caggcacagg 960agttgctctt cccaaagagt tttggtatct ttctctccat tctaggttat tcggagcccc 1020ctttttaccg ttaaggagat ctgagttaat ggcttgctca agttcccagg aatcggttgt 1080ggactgagga actcggcccc gggtcttagt acgcgtccct tgttcaggta tccagggagt 1140tctcacctct gtcttttctc cttcaggtga ctcctgcacc tgcgccggct cctgcaaatg 1200caaagagtgc aaatgcacct cctgcaagaa aagtaagtgg gatcctctct ttcctctacc 1260ccttccctgt cctccagcct gtcccctctc caccatcctc aggggaatta aagcagtctg 1320gggatgcccc attgcgcgga aattgttgcc tcctcagtga tcttatcagg gagagcagga 1380atccttattc ccggtgtcgc tagtactcat ctctgcgcct cctgtctgcc cccaggctgc 1440tgctcctgct gccctgtggg ctgtgccaag tgtgcccagg gctgcatctg caaaggggcg 1500tcggacaagt gcagctgctg cgcctgatgc tgggacagcc ccgctcccag atgtaaagaa 1560cgcgacttcc acaaacctgg attttttatg tacaaccctg accgtgaccg tttgctatat 1620tcctttttct ataaaataat gtgaatgata ataaaacagc tttgacttga ttctgtctct 1680ggttttcttt atatgcctta aaa 1703 60 2932 DNA Homo sapiens 60aggcccggtt cgccgccgct tcctgctgcc gccatgctcg acttcttcac cattttctcc 60aagggcgggc ttgtgctctg gtgcttccag ggcgttagcg actcatgcac cggacccgtt 120aacgcgttga ttcgttccgt gctgctgcag gaacggggag gtaacaactc cttcacccat 180gaggcactga cactcaagta taaactggac aaccagtttg agctggtgtt tgtggttggt 240tttcagaaga tcctgacact gacatatgta gacagattga tagatgacgt gcatcggctg 300tttcgggaca agtaccgcac agagatccaa cagcaaagtg ctttaagttt attaaatggc 360acttttgatt tccaaaatga cttcctgcgg ctccttcgtg aagcagagga gagcagtaag 420atccgtgctc ccactaccat gaagaaattt gaagattctg aaaaggccaa gaaacctgtg 480aggtccatga ttgagacacg gggggaaaag cccaaggaaa aagcaaagaa tagcaaaaaa 540aagggggcca agaaggaagg ttctgatggt cctttggcta ccagcaaacc agtccctgca 600gaaaagtcag gtcttccagt gggtcctgag aacgaggtag aactttccaa agaggagctg 660atccgcagga agcgcgagga gttcattcag aagcatggga ggggtatgga gaagtccaac 720aagtccacga agtcagatgc tccaaaggag aagggcaaaa aagcaccccg ggtgtgggaa 780ctgggtggct gtgctaacaa agaagtgttg gattacagta ctcccaccac caatggaacc 840cctgaggctg ccttgtctga ggacatcaac ctgattcgag ggactgggtc tggggggcag 900cttcaggatc tggactgcag cagctctgat gacgaagggg ctgctcaaac tctcaccaaa 960cctagtgcga ccaagggaac actgggtggc atgtttggta tgctgaaggg ccttgtgggt 1020tcaaagagct tgagtcgtga agacatggaa tctgtgctgg acaagatgcg tgatcatctc 1080attgctaaga acgtggctgc agacattgcc gtccagctct gtgaatctgt tgccaacaag 1140ttggaaggga aggtgatggg gacgttcagc acggtgactt ccacagtaaa gcaagcccta 1200caggagtccc tggtgcagat tctgcagcca cagcgtcgtg tagacatgct ccgggacatc 1260atggatgccc agcgtcgcca gcgcccttat gtcgtcacct tctgcggcgt taatggagtg 1320gggaaatcta ctaatcttgc caagatttcc ttctggttgt tagagaatgg cttcagtgtc 1380ctcattgctg cctgtgatac atttcgtgct ggggccgtgg agcagctgcg tacacacacc 1440cggcgtttga gtgccctaca ccctccagag aagcatggtg gccgcaccat ggtgcagttg 1500tttgaaaagg gctatggcaa ggatgctgct ggcattgcca tggaagccat tgcttttgca 1560cgtaaccaag gctttgacgt ggtgctggtg gacacggcag gccgcatgca agacaatgcc 1620cctctgatga ctgccctggc caaactcatt actgtcaata cacctgattt ggtgctgttt 1680gtaggagaag ccttagtagg caatgaagcc gtggaccagc tggtcaagtt caacagagcc 1740ttggctgacc attctatggc tcagacacct cggctcattg atggcattgt tcttaccaaa 1800tttgatacca ttgatgacaa ggtgggagct gctatttcta tgacgtacat cacaagcaaa 1860cccatcgtct ttgtgggcac cggccagacc tactgtgacc tacgcagcct caatgccaag 1920gctgtggtgg ctgccctcat gaaggcttaa cgtggctctt gcccaatacc aaatcgccgc 1980tttccccaca agcccttctt cctgtatcaa gaatgtgctt tagagtatgt gagcaacctg 2040tcttaagtgt agtacaaagg cagagtgagg gggcttgtgg ctccttccaa ccccactccc 2100cgttcagcac agccgccatt tgcaaggaag gcctaatcat gttacaatca ctgcccgact 2160gaccctctcc cagcggcctc ccccttccta ctcaggcacc cccttcactc tgcctacaga 2220ctcagtctta ttacagcttt gaccaatggt tggaacccaa caccagagct ttgctaataa 2280tgagtgtggt caagagccgt ctgagcctaa tgagtcccag ctgcattagg ttaagagact 2340cttccagagc cagcgccagg tcttgaatgg cacctctccc taggatacac agcctgcagg 2400tccccaggac ctgatgacac ccgcctcact gtggcagtgt attgcctgtt aattgctgct 2460aattctaatt ctgatgatga ctcctactcc attgtttacc ccaaagcatc agctaggctg 2520gagtgatttg ttacaaatga gcaaaagatg agtccttgct tccctcagaa ataaaagtag 2580cccagctgca gcgttgcatt ggcttcttgg cctcccaact cttccactcc cagaatcaga 2640agtaagctct gcatgttccc ttcctggagg aaaccaattg tcagaaggtg tatgatgacc 2700ccctcccctc ccatccttca cctcctaagc agtcctggct tttcctcatc actcccctct 2760acagtgcctg gtagacaagt gctacattga agaacacaaa cctcttgtta agacttgtcc 2820tgtagcttga tattacaggt gtgctattag tgcaataagg tgaaggctgt ctgcccagag 2880aaataagtaa tttatataag aaaataaatt tcataaataa attggaaatt cc 2932 61 2165 DNA Homo sapiens 61cccgccttcc atacctcccc ggctccgctc ggttcctggc caccccgcag cccctgccca 60ggtgccatgg ccgcattgta ccgccctggc ctgcggctta actggcatgg gctgagcccc 120ttgggctggc catcatgccg tagcatccag accctgcgag tgcttagtgg agatctgggc 180cagcttccca ctggcattcg agattttgta gagcacagtg cccgcctgtg ccaaccagag 240ggcatccaca tctgtgatgg aactgaggct gagaatactg ccacactgac cctgctggag 300cagcagggcc tcatccgaaa gctccccaag tacaataact gctggctggc ccgcacagac 360cccaaggatg tggcacgagt agagagcaag acggtgattg taactccttc tcagcgggac 420acggtaccac tcccgcctgg tggggcctgt gggcagctgg gcaactggat gtccccagct 480gatttccagc gagctgtgga tgagaggttt ccaggctgca tgcagggccg caccatgtat 540gtgcttccat tcagcatggg tcctgtgggc tccccgctgt cccgcatcgg ggtgcagctc 600actgactcag cctatgtggt ggcaagcatg cgtattatga cccgactggg gacacctgtg 660cttcaggccc tgggagatgg tgactttgtc aagtgtctgc actccgtggg ccagcccctg 720acaggacaag gggagccagt gagccagtgg ccgtgcaacc cagagaaaac cctgattggc 780cacgtgcccg accagcggga gatcatctcc ttcggcagcg gctatggtgg caactccctg 840ctgggcaaga agtgctttgc cctacgcatc gcctctcggc tggcccggga tgagggctgg 900ctggcagagc acatgctgat cctgggcatc accagccctg cagggaagaa ggcgctatgt 960gcagccgcct tccctagtgc ctgtggcaag accaacctgg ctatgatgcg gcctgcactg 1020ccaggctgga aagtggagtg tgtgggggat gatattgctt ggatgaggtt tgacagtgaa 1080ggtcgactcc gggccatcaa ccctgagaac ggcttctttg gggttgcccc tggtacctct 1140gccaccacca atcccaacgc catggctaca atccagagta acactatttt taccaatgtg 1200gctgagacca gtgatggtgg cgtgtactgg gagggcattg accagcctct tccacctggt 1260gttactgtga cctcctggct gggcaaaccc tggaaacctg gtgacaagga gccctgtgca 1320catcccaact ctcgattttg tgccccggct cgccagtgcc ccatcatgga cccagcctgg 1380gaggccccag agggtgtccc cattgacgcc atcatctttg gtggccgcag acccaaaggg 1440gtacccctgg tatacgaggc cttcaactgg cgtcatgggg tgtttgtggg cagagccatg 1500cgctctgagt ccactgctgc agcagaacac aaagggaaga tcatcatgca cgacccattt 1560gccatgcggc ccttttttgg ctacaacttc gggcactacc tggaacactg gctgagcatg 1620gaagggcgca agggggccca gctgccccgt atcttccatg tcaactggtt ccggcgtgac 1680gaggcagggc acttcctgtg gccaggcttt ggggagaatg ctcgggtgct agactggatc 1740tgccggcggt tagaggggga ggacagtgcc cgagagacac ccattgggct ggtgccaaag 1800gaaggagcct tggatctcag cggcctcaga gctatagaca ccactcagct gttctccctc 1860cccaaggact tctgggaaca ggaggttcgt gacattcgga gctacctgac agagcaggtc 1920aaccaggatc tgcccaaaga ggtgttggct gagcttgagg ccctggagag acgtgtgcac 1980aaaatgtgac ctgaggccta gtctagcaag aggacatagc accctcatct gggaataggg 2040aaggcacctt gcagaaaata tgagcaattg atattaacta acatcttcaa tgtgccatag 2100accttcccac aaagactgtc caataataag agatgcttat ctattttaaa aaaaaaaaaa 2160aaaaa 2165 62 660 DNA Homo sapiens 62gccgccgycg aggattcagc agcctccccc ttgagccccc tcgcttcccg acgttccgtt 60cccccctgcc cgccttctcc cgccaccgcc gccgccgcct tccgcagccg tttccaccga 120ggaaaaggaa tcgtatcgta tgtccgctat ccagaacctc cactctttcg acccctttgc 180tgatgcaagt aagggtgatg acctgcttcc tgctggcact gaggattata tccatataag 240aattcaacag agaaacggca ggaagaccct tactactgtc caagggatcg ctgatgatta 300cgataaaaag aaactagtga aggcgtttaa gaaaaagttt gcctgcaatg gtactgtaat 360tgagcatccg gaatatggag aagtaattca gctacagggt gaccaacgca agaacatatg 420ccagttcctc gtagagattg gactggctaa ggacgatcag ctgaaggttc atgggtttta 480agtgcttgtg gctcactgaa gcttaagtga ggatttcctt gcaatgagta gaatttccct 540tctctccctt gtcacaggtt taaaaacctc acagcttgta taatgtaacc atttggggtc 600cgcttttaac ttggactagt gtaactcctt catgcaataa actgaaaaga gccatgcaaa 660 63 794 DNA Homo sapiens 63cccccccccc cccccccagc cagtgggttc ccgcgcgtgc cgagactctg aggccttgca 60cccccacgat cccgtacgat ggccgtcaag aagatcgcga tcttcggcgc cactggccag 120accgggctca ccaccctggc gcaggcggtg caagcaggtt acgaagtgac agtgctggtg 180cgggactcct ccaggctgcc atcagagggg ccccggccgg cccacgtggt agtgggagat 240gttctgcagg cagccgatgt ggacaagacc gtggctgggc aggacgctgt catcgtgctg 300ctgggcaccc gcaatgacct cagtcccacg acagtgatgt ccgagggcgc ccggaacatt 360gtggcagcca tgaaggctca tggtgtggac aaggtcgtgg cctgcacctc ggctttcctg 420ctctgggacc ctaccaaggt gcccccacga ctgcaggctg tgactgatga ccacatccgg 480atgcacaagg tgctgcggga atcaggcctg aagtacgtgg ctgtgatgcc gccacacata 540ggagaccagc cactaactgg ggcgtacaca gtgaccctgg atggacgagg gccctcaagg 600gtcatctcca aacatgacct gggccatttc atgctgcgct gcctcaccac cgatgagtac 660gacggacaca gcacctaccc ctcccaccag taccagtagc actctgtccc catctgggag 720ggtggcattc tgggacatga ggagcaaagg aagggggcaa taaatgttga gccaagagct 780tcaaattact ctag 794 64 851 DNA Homo sapiens 64cgggaacgca acatgaaggt gctccttgcc gccgccctca tcgcggggtc cgtcttcttc 60ctgctgctgc cgggaccttc tgcggccgat gagaagaaga aggggcccaa agtcaccgtc 120aaggtgtatt ttgacctacg aattggagat gaagatgtag gccgggtgat ctttggtctc 180ttcggaaaga ctgttccaaa aacagtggat aattttgtgg ccttagctac aggagagaaa 240ggatttggct acaaaaacag caaattccat cgtgtaatca aggacttcat gatccagggc 300ggagacttca ccaggggaga tggcacagga ggaaagagca tctacggtga gcgcttcccc 360gatgagaact tcaaactgaa gcactacggg cctggctggg tcagcatggc caacgcaggc 420aaagacacca acggctccca gttcttcatc acgacagtca agacagcctg gctagatggc 480aagcatgtgg tgtttggcaa agttctagag ggcatggagg tggtgcggaa ggtggagagc 540accaagacag acagccggga taaacccctg aaggatgtga tcatcgcaga ctgcggcaag 600atcgaggtgg agaagccctt tgccatcgcc aaggagtagg gcacagggac atctttcttt 660gagtgaccgt ctgtgcaggc cctgtagtcc gccacagggc tctgagctgc actggccccg 720gtgctggcat ctggtggagc ggacccactc ccctcacatt ccacaggccc atggactcac 780ttttgtaaca aactcctacc aacactgacc aataaaaaaa aatgtgggtt tttttttttt 840ttaataaaaa a 851 65 1941 DNA Homo sapiens 65tctcttgatt cctagtctct cgatatggca cctccgtcag tctttgccga ggttccgcag 60gcccagcctg tcctggtctt caagctcact gccgacttca gggaggatcc ggacccccgc 120aaggtcaacc tgggagtggg agcatatcgc acggatgact gccatccctg ggttttgcca 180gtagtgaaga aagtggagca gaagattgct aatgacaata gcctaaatca cgagtatctg 240ccaatcctgg gcctggctga gttccggagc tgtgcttctc gtcttgccct tggggatgac 300agcccagcac tcaaggagaa gcgggtagga ggtgtgcaat ctttgggggg aacaggtgca 360cttcgaattg gagctgattt cttagcgcgt tggtacaatg gaacaaacaa caagaacaca 420cctgtctatg tgtcctcacc aacctgggag aatcacaatg ctgtgttttc cgctgctggt 480tttaaagaca ttcggtccta tcgctactgg gatgcagaga agagaggatt ggacctccag 540ggcttcctga atgatctgga gaatgctcct gagttctcca ttgttgtcct ccacgcctgt 600gcacacaacc caactgggat tgacccaact ccggagcagt ggaagcagat tgcttctgtc 660atgaagcacc ggtttctgtt ccccttcttt gactcagcct atcagggctt cgcatctgga 720aacctggaga gagatgcctg ggccattcgc tattttgtgt ctgaaggctt cgagttcttc 780tgtgcccagt ccttctccaa gaacttcggg ctctacaatg agagagtcgg gaatctgact 840gtggttggaa aagaacctga gagcatcctg caagtccttt cccagatgga gaagatcgtg 900cggattactt ggtccaatcc ccccgcccag ggagcacgaa ttgtggccag caccctctct 960aaccctgagc tctttgagga atggacaggt aatgtgaaga caatggctga ccggattctg 1020accatgagat ctgaactcag ggcacgacta gaagccctca aaacccctgg gacctggaac 1080cacatcactg atcaaattgg catgttcagc ttcactgggt tgaaccccaa gcaggttgag 1140tatctggtca atgaaaagca catctacctg ctgccaagtg gtcgaatcaa cgtgagtggc 1200ttaaccacca aaaatctaga ttacgtggcc acctccatcc atgaagcagt caccaaaatc 1260cagtgaagaa acaccacccg tccagtacca ccaaagtagt tctctgtcat gtgtgttccc 1320tgcctgcaca aacctacatg tacataccat ggattagaga cacttgcagg actgaaagct 1380gctctggtga ggcagcctct gtttaaaccg gccccacatg aagagaacat cccttgagac 1440gaatttggag actgggatta gagcctttgg aggtcaaagc aaattaagat ttttatttaa 1500gaataaaaga gtactttgat catgagacat aggtatcttg tccctctcac taaaaaggag 1560tgttgtgtgt ggcggccacg tgcttctatg tggtgtttga ctctgtacaa attctagtcc 1620caaagatcaa gttgtctgaa ggagccaaag tgtgaatgtg ggtgtcggct gcggcattaa 1680attcatcatc tcaacccaga gtgtctggtc tccctgctct ttctgcatgg ttgtgtccct 1740agtcctaagc tttggttctt tagggtgact gtggtaagaa ggatatttaa tcatgacatg 1800cacggacacg tacatattta actgaaacaa gttttaccaa acagtattta ctcgtgatgt 1860gcgtagtgca ttctgatatt tttgagccat tctattgtgt tctacttcac ctaaaaaaat 1920aaaataaaaa tgttgatcaa g 1941 66 2736 DNA Homo sapiens 66ttgcactctc ccacaccctt ttcttttcgt ccgctcttcg cttatttctc ccgccgtctc 60ctctgcataa gaaggggaac gaaagatggc ggcggaaacg ctgctgtcca gtttgttagg 120actgctgctt ctgggactcc tgttacccgc aagtctgacc ggcggtgtcg ggagcctgaa 180cctggaggag ctgagtgaga tgcgttatgg gatcgagatc ctgccgttgc ctgtcatggg 240agggcagagc caatcttcgg acgtggtgat tgtctcctct aagtacaaac agcgctatga 300gtgtcgcctg ccagctggag ctattcactt ccagcgtgaa agggaggagg aaacacctgc 360ttaccaaggg cctgggatcc ctgagttgtt gagcccaatg agagatgctc cctgcttgct 420gaagacaaag gactggtgga catatgaatt ctgttatgga cgccacatcc agcaatacca 480catggaagat tcagagatca aaggtgaagt cctctatctc ggctactacc aatcagcctt 540cgactgggat gatgaaacag ccaaggcctc caagcagcat cgtcttaaac gctaccacag 600ccagacctat ggcaatgggt ccaagtgcga ccttaatggg aggccccggg aggccgaggt 660tcggttcctc tgtgacgagg gtgcaggtat ctctggggac tacatcgatc gcgtggacga 720gcccttgtcc tgctcttatg tgctgaccat tcgcactcct cggctctgcc cccaccctct 780cctccggccc ccacccagtg ctgcaccaca ggccatcctc tgtcaccctt ccctacagcc 840tgaggagtac atggcctacg ttcagaggca agccgactca aagcagtatg gagataaaat 900catagaggag ctgcaagatc taggccccca agtgtggagt gagaccaagt ctggggtggc 960accccaaaag atggcaggtg cgagcccgac caaggatgac agtaaggact cagatttctg 1020gaagatgctt aatgagccag aggaccaggc cccaggaggg gaggaggtgc cggctgagga 1080gcaggaccca agccctgagg cagcagattc agcttctggt gctcccaatg attttcagaa 1140caacgtgcag gtcaaagtca ttcgaagccc tgcggatttg attcgattca tagaggagct 1200gaaaggtgga acaaaaaagg ggaagccaaa tataggccaa gagcagcctg tggatgatgc 1260tgcagaagtc cctcagaggg aaccagagaa ggaaaggggt gatccagaac ggcagagaga 1320gatggaagaa gaggaggatg aggatgagga tgaggatgaa gatgaggatg aacggcagtt 1380actgggagaa tttgagaagg aactggaagg gatcctgctt ccgtcagacc gagaccggct 1440ccgttcggag gtgaaggctg gcatggagcg ggaactggag aacatcatcc aggagacaga 1500gaaagagctg gacccagatg ggctgaagaa ggagtcagag cgggatcggg caatgctggc 1560tctcacatcc actctcaaca aactcatcaa aagactggag gaaaaacaga gtccagagct 1620ggtgaagaag cacaagaaaa agagggttgt ccccaaaaag cctcccccat caccccaacc 1680tacagaggag gatcctgagc acagagtccg ggtccgggtc accaagctcc gtctcggagg 1740ccctaatcag gatctgactg tcctcgagat gaaacgggaa aacccacagc tgaaacaaat 1800cgaggggctg gtgaaggagc tgctggagag ggagggactc acagctgcag ggaaaattga 1860gatcaaaatt gtccgcccat gggctgaagg gactgaagag ggtgcacgtt ggctgactga 1920tgaggacacg agaaacctca aggagatctt cttcaatatc ttggtgccgg gagctgaaga 1980ggcccagaag gaacgccagc ggcagaaaga gctggagagc aattaccgcc gggtgtgggg 2040ctctccaggt ggggagggca caggggacct ggacgaattt gacttctgag accaacacta 2100cacttgaccc ttcacggaat ccagactctt cctggactgg cttgcctcct ccccacctcc 2160ccaccctgga acccctgagg gccaaacagc agagtggagc tgagctgtgg acctctcggg 2220caactctgtg ggtgtggggg ccctgggtga atgctgctgc ccctgctggc agccaccttg 2280agacctcacc gggcctgtga tatttgctct cctgaactct cactcaatcc tcttcctctc 2340ctctgtggct tttcctgtta ttgtccccta atgataggat attccctgct gcctacctgg 2400agattcagta ggatcttttg agtggaggtg ggtagagaga gcaaggaggg caggacactt 2460agcaggcact gagcaagcag gcccccacct gcccttagtg atgtttggag tcgttttacc 2520ctcttctatt gaattgcctt gggatttcct tctccctttc cctgcccacc ctgtccccta 2580caatttgtgc ttctgagttg aggagccttc acctctgttg ctgaggaaat ggtagaatgc 2640tgcctatcac ctccagcaca atcccagcga aaaaggtgtg aagcacccac catgttcttg 2700aacaatcagg tttctaaata aacaactgga ccatca 2736 67 1860 DNA Homo sapiens 67cgtgaacggt cgttgcagag attgcgggcg gctgagacgc cgcctgcctg gcacctagga 60gcgcagcgga gccccgacac cgccgccgcc gccatggagt ccgagaccga acccgagccc 120gtcacgctcc tggtgaagag ccccaaccag cgccaccgcg acttggagct gagtggcgac 180cgcggctgga gtgtgggcca cctcaaggcc cacctgagcc gcgtctaccc cgagcgtccg 240cgtccagagg accagaggtt aatttattct gggaagctgt tgttggatca ccaatgtctc 300agggacttgc ttccaaagca ggaaaaacgg catgttttgc atctggtgtg caatgtgaag 360agtccttcaa aaatgccaga aatcaacgcc aaggtggctg aatccacaga ggagcctgct 420ggttctaatc ggggacagta tcctgaggat tcctcaagtg atggtttaag gcaaagggaa 480gttcttcgga acctttcttc ccctggatgg gaaaacatct caaggcctga agctgcccag 540caggcattcc aaggcctggg tcctggtttc tccggttaca caccctatgg gtggcttcag 600ctttcctggt tccagcagat atatgcacga cagtactaca tgcaatattt agcagccact 660gctgcatcag gggcttttgt tccaccacca agtgcacaag agatacctgt ggtctctgca 720cctgctccag cccctattca caaccagttt ccagctgaaa accagcctgc caatcagaat 780gctgctcctc aagtggttgt taatcctgga gccaatcaaa atttgcggat gaatgcacaa 840ggtggcccta ttgtggaaga agatgatgaa ataaatcgag attggttgga ttggacctat 900tcagcagcta cattttctgt ttttctcagt atcctctact tctactcctc cctgagcaga 960ttcctcatgg tcatgggggc caccgttgtt atgtacctgc atcacgttgg gtggtttcca 1020tttagaccga ggccggttca gaacttccca aatgatggtc ctcctcctga cgttgtaaat 1080caggacccca acaataactt acaggaaggc actgatcctg aaactgaaga ccccaaccac 1140ctccctccag acagggatgt actagatggc gagcagacca gcccctcctt tatgagcaca 1200gcatggcttg tcttcaagac tttctttgcc tctcttcttc cagaaggccc cccagccatc 1260gcaaactgat ggtgtttgtg ctgtagctgt tggaggcttt gacaggaatg gactggatca 1320cctgactcca gctagattgc ctctcctgga catggcaatg atgagttttt aaaaaacagt 1380gtggatgatg atatgctttt gtgagcaagc aaaagcagaa acgtgaagcc gtgatacaaa 1440ttggtgaaca aaaaatgccc aaggcttctc atgtgtttat tctgaagagc tttaatatat 1500actctatgta gtttaataag cactgtacgt agaaggcctt aggtgttgca tgtctatgct 1560tgaggaactt ttccaaatgt gtgtgtctgc atgtgtgttt gtacatagaa gtcatagatg 1620cagaagtggt tctgctggta agatttgatt cctgttggaa tgtttaaatt acactaagtg 1680tactacttta tataatcaat gaaattgcta gacatgtttt agcaggactt ttctaggaaa 1740gacttatgta taattgcttt ttaaaatgca gtgctttact ttaaactaag gggaactttg 1800cggaggtgaa aacctttgct gggttttctg ttcaataaag ttttactatg aatgaccctg 1860 68 3082 DNA Homo sapiens 68agggagtcgt gtcggcgcca ccccggcccc cgagcccgca gattgcccac cgaagctcgt 60gtgtgcaccc ccgatcccgc cagccactcg cccctggcct cgcgggccgt gtctccggca 120tcatgtgtgg tatatttgct tacttaaact accatgttcc tcgaacgaga cgagaaatcc 180tggagaccct aatcaaaggc cttcagagac tggagtacag aggatatgat tctgctggtg 240tgggatttga tggaggcaat gataaagatt gggaagccaa tgcctgcaaa acccagctta 300ttaagaagaa aggaaaagtt aaggcactgg atgaagaagt tcacaagcaa caagatatgg 360atttggatat agaatttgat gtacaccttg gaatagctca tacccgttgg gcaacacatg 420gagaacccag tcctgtcaat agccaccccc agcgctctga taaaaataat gaatttatcg 480ttattcacaa tggaatcatc accaactaca aagacttgaa aaagtttttg gaaagcaaag 540gctatgactt cgaatctgaa acagacacag agacaattgc caagctcgtt aagtatatgt 600atgacaatcg ggaaagtcaa gataccagct ttactacctt ggtggagaga gttatccaac 660aattggaagg tgcttttgca cttgtgttta aaagtgttca ttttcccggg caagcagttg 720gcacaaggcg aggtagccct ctgttgattg gtgtacggag tgaacataaa ctttctactg 780atcacattcc tatactctac agaacaggca aagacaagaa aggaagctgc aatctctctc 840gtgtggacag cacaacctgc cttttcccgg tggaagaaaa agcagtggag tattactttg 900cttctgatgc aagtgctgtc atagaacaca ccaatcgcgt catctttctg gaagatgatg 960atgttgcagc agtagtggat ggacgtcttt ctatccatcg aattaaacga actgcaggag 1020atcaccccgg acgagctgtg caaacactcc agatggaact ccagcagatc atgaagggca 1080acttcagttc atttatgcag aaggaaatat ttgagcagcc agagtctgtc gtgaacacaa 1140tgagaggaag agtcaacttt gatgactata ctgtgaattt gggtggtttg aaggatcaca 1200taaaggagat ccagagatgc cggcgtttga ttcttattgc ttgtggaaca agttaccatg 1260ctggtgtagc aacacgtcaa gttcttgagg agctgactga gttgcctgtg atggtggaac 1320tagcaagtga cttcctggac agaaacacac cagtctttcg agatgatgtt tgctttttcc 1380ttagtcaatc aggtgagaca gcagatactt tgatgggtct tcgttactgt aaggagagag 1440gagctttaac tgtggggatc acaaacacag ttggcagttc catatcacgg gagacagatt 1500gtggagttca tattaatgct ggtcctgaga ttggtgtggc cagtacaaag gcttatacca 1560gccagtttgt atcccttgtg atgtttgccc ttatgatgtg tgatgatcgg atctccatgc 1620aagaaagacg caaagagatc atgcttggat tgaaacggct gcctgatttg attaaggaag 1680tactgagcat ggatgacgaa attcagaaac tagcaacaga actttatcat cagaagtcag 1740ttctgataat gggacgaggc tatcattatg ctacttgtct tgaaggggca ctgaaaatca 1800aagaaattac ttatatgcac tctgaaggca tccttgctgg tgaattgaaa catggccctc 1860tggctttggt ggataaattg atgcctgtga tcatgatcat catgagagat cacacttatg 1920ccaagtgtca gaatgctctt cagcaagtgg ttgctcggca ggggcggcct gtggtaattt 1980gtgataagga ggatactgag accattaaga acacaaaaag aacgatcaag gtgccccact 2040cagtggactg cttgcagggc attctcagcg tgatcccttt acagttgctg gctttccacc 2100ttgctgtgct gagaggctat gatgttgatt tcccacggaa tcttgccaaa tctgtgactg 2160tagagtgagg aatatctata caaaatgtac gaaactgtat gattaagcaa cacaagacac 2220cttttgtatt taaaaccttg atttaaaata tcaccccttg aagccttttt ttagtaaatc 2280cttatttata tatcagttat aattattcca ctcaatatgt gatttttgtg aagttacctc 2340ttacattttc ccagtaattt gtggaggact ttgaataatg gaatctatat tggaatctgt 2400atcagaaaga ttctagctat tattttcttt aaagaatgct gggtgttgca tttctggacc 2460ctccacttca atctgagaag acaatatgtt tctaaaaatt ggtacttgtt tcaccatact 2520tcattcagac cagtgaaaga gtagtgcatt taattggagt atctaaagcc agtggcagtg 2580tatgctcata cttggacagt tagggaaggg tttgccaagt tttaagagaa gatgtgattt 2640attttgaaat ttgtttctgt tttgttttta aatcaaactg taaaacttaa aactgaaaaa 2700ttttattggt aggatttata tctaagtttg gttagcctta gtttctcaga cttgttgtct 2760attatctgta ggtggaagaa atttaggaag cgaaatatta cagtagtgca ttggtgggtc 2820tcaatcctta acatatttgc acaattttat agcacaaact ttaaattcaa gctgctttgg 2880acaactgaca atatgatttt aaatttgaag atgggatgtg tacatgttgg gtatcctact 2940actttgtgtt ttcatctcct aaaagtgttt tttatttcct tgtatctgta gtcttttatt 3000ttttaaatga ctgctgaatg acatatttta tcttgttctt taaaatcaca acacagagct 3060gctattaaat taatattgat at 3082 69 1815 DNA Homo sapiens 69aaaccaacgc ctggctcgga gcagcagcct ctgaggtgtc cctggccagt gtccttccac 60ctgtccacaa gcatggggaa catcttcgcc aacctcttca agggcctttt tggcaaaaaa 120gaaatgcgca tcctcatggt gggcctggat gctgcaggga agaccacgat cctctacaag 180cttaagctgg gtgagatcgt gaccaccatt cccaccatag gcttcaacgt ggaaaccgtg 240gagtacaaga acatcagctt cactgtgtgg gacgtgggtg gccaggacaa gatccggccc 300ctgtggcgcc actacttcca gaacacacaa ggcctgatct tcgtggtgga cagcaatgac 360agagagcgtg tgaacgaggc ccgtgaggag ctcatgagga tgctggccga ggacgagctc 420cgggatgctg tcctcctggt gttcgccaac aagcaggacc tccccaacgc catgaatgcg 480gccgagatca cagacaagct ggggctgcac tcactacgcc acaggaactg gtacattcag 540gccacctgcg ccaccagcgg cgacgggctc tatgaaggac tggactggct gtccaatcag 600ctccggaacc agaagtgaac gcgacccccc tccctctcac tcctcttgcc ctctgcttta 660ctctcatgtg gcaaacgtgc ggctcgtggt gtgagtgcca gaagctgcct ccgtggtttg 720gtcaccgtgt gcatcgcacc gtgctgtaaa tgtggcagac gcagcctgcg gccaggcttt 780ttatttaatg taaatagttt ttgtttccaa tgaggcagtt tctggtactc ctatgcaata 840ttactcagct ttttttattg taaaaagaaa aatcaactca ctgttcagtg ctgagagggg 900atgtaggccc atgggcacct ggcctccagg agtcgctgtg ttgggagagc cggccacgcc 960cttggcttta gagctgtgtt gaaatccatt ttggtggttg gtttttaacc caaactcagt 1020gcatttttta aaatagttaa gaatccaagt cgagaacact tgaacacaca gaagggagac 1080cccgcctagc atagatttgc agttacggcc tggatgccag tcgccagccc agctgttccc 1140ctcgggaaca tgaggtggtg gtggcgcagc agactgcgat caattctgca tggtcacagt 1200agagatcccc gcaactcgct tgtccttggg tcaccctgca ttccatagcc atgtgcttgt 1260ccctgtgctc ccacggttcc caggggccag gctgggagcc cacagccacc ccactatgcc 1320gcaggccgcc ctacccacct tcaggcagcc tatgggacgc agggccccat ctgtccctcg 1380gtcgccgtgt ggccagagtg ggtccgtcgt ccccaacact cgtgctcgct cagacacttt 1440ggcaggatgt ctggggcctc accagcagga gcgcgtgcaa gccgggcagg cggtccacct 1500agacccacag cccctcggga gcaccccacc tctgtgtgtg atgtagcttt ctctccctca 1560gcctgcaagg gtccgatttg ccatcgaaaa agacaacctc tacttttttc ttttgtattt 1620tgataaacac tgaagctgga gctgttaaat ttatcttggg gaaacctcag aactggtcta 1680tttggtgtcg tggaacctct tactgctttc aatacacgat tagtaatcaa ctgttttgta 1740tacttgtttt cagttttcat ttcgacaaac aagcactgta attatagcta ttagaataaa 1800atctcttaac tattt 1815 70 2462 DNA Homo sapiens 70gctccccatt gtccttgtca atactgtgag actcatccaa tatcctatcc acctctacgt 60agtctggatt aaagggctct tcatcctcat ggaagaagtg tctcatctga gccagggggg 120gcggcgattt catcatgctc cgagccggcg gcgcgcgccg cttccgtcgc caccctctct 180ggacagccca gggccgcacg tcatgccctc tccgcgtcca gtgctgctta gaggtgctcg 240cgccgctctg ctgctgctgc tgccgccccg gctcttagcc cgaccctcgc tcctgctccg 300ccggtccctc agcgcggcct cctgcgcccc gatctccttg cccgccgccg cctcccggag 360cagcatggac ggcgcggggg ctgaggaggt gctggctcct ctgaggctag cagtgcgcca 420gcagggagat cttgtgcgaa aactcaaaga agataaagca ccccaagtag acgtagacaa 480agcagtggct gagctcaaag cccgcaagag ggttctggaa gcaaaggagc tggcgttaca 540gcccaaagat gatattgtag accgagcaaa aatggaagat accctgaaga ggaggttttt 600ctatgatcaa gcttttgcta tttatggagg tgttagtggt ctgtatgact ttgggccagt 660tggctgtgct ttgaagaaca atattattca gacctggagg cagcacttta tccaagagga 720acagatcctg gagatcgatt gcaccatgct cacccctgag ccagttttaa agacctctgg 780ccatgtagac aaatttgctg acttcatggt gaaagacgta aaaaatggag aatgttttcg 840tgctgaccat ctattaaaag ctcatttaca gaaattgatg tctgataaga agtgttctgt 900cgaaaagaaa tcagaaatgg aaagtgtttt ggcccagctt gataactatg gacagcaaga 960acttgcggat ctttttgtga actataatgt aaaatctccc attactggaa atgatctatc 1020ccctccagtg tcttttaact taatgttcaa gactttcatt gggcctggag gaaacatgcc 1080tgggtacttg agaccagaaa ctgcacaggg gattttcttg aatttcaaac gacttttgga 1140gttcaaccaa ggaaagttgc cttttgctgc tgcccagatt ggaaattctt ttagaaatga 1200gatctcccct cgatctggac tgatcagagt cagagaattc acaatggcag aaattgagca 1260ctttgtagat cccagtgaga aagaccaccc caagttccag aatgtggcag accttcacct 1320ttatttgtat tcagcaaaag cccaggtcag cggacagtcc gctcggaaaa tgcgcctggg 1380agatgctgtt gaacagggtg tgattaataa cacagtatta ggctatttca ttggccgcat 1440ctacctctac ctcacgaagg ttggaatatc tccagataaa ctccgcttcc ggcagcacat 1500ggagaatgag atggcccatt atgcctgtga ctgttgggat gcagaatcca aaacatccta 1560cggttggatt gagattgttg gatgtgctga tcgttcctgt tatgacctct cctgtcatgc 1620acgagccacc aaagtcccac ttgtagctga gaaacctctg aaagaaccca aaacagtcaa 1680tgttgttcag tttgaaccca gtaagggagc aattggtaag gcatataaga aggatgcaaa 1740actggtgatg gagtatcttg ccatttgtga tgagtgctac attacagaaa ttgagatgct 1800gctgaatgag aaaggggaat tcacaattga aactgaaggg aaaacatttc agttaacaaa 1860agacatgatc aatgtgaaga gattccagaa aacactatat gtggaagaag ttgttccgaa 1920tgtaattgaa ccttccttcg gcctgggtag gatcatgtat acggtatttg aacatacatt 1980ccatgtacga gaaggagatg aacagagaac attcttcagt ttccctgctg tagttgctcc 2040attcaaatgt tccgtcctcc cactgagcca aaaccaggag ttcatgccat ttgtcaagga 2100attatcggaa gccctgacca ggcatggagt atctcacaaa gtagacgatt cctctgggtc 2160aatcggaagg cgctatgcca ggactgatga gattggcgtg gcttttggtg tcaccattga 2220ctttgacaca gtgaacaaga ccccccacac tgcaactctg agggaccgtg actcaatgcg 2280gcagataaga gcagagatct ctgagctgcc cagcatagtc caagacctag ccaatggcaa 2340catcacatgg gctgatgtgg aggccaggta tcctctgttt gaagggcaag agactggtaa 2400aaaagagaca atcgaggaat gaggacaatt ttgacaactt ttgaccactt gcgctaataa 2460aa 2462 71 2415 DNA Homo sapiens 71cggcgccgcg agcttctcct ctcctcacga ccgaggcaga gcagtcatta tggcgaacct 60tggctgctgg atgctggttc tctttgtggc cacatggagt gacctgggcc tctgcaagaa 120gcgcccgaag cctggaggat ggaacactgg gggcagccga tacccggggc agggcagccc 180tggaggcaac cgctacccac ctcagggcgg tggtggctgg gggcagcctc atggtggtgg 240ctgggggcag cctcatggtg gtggctgggg gcagccccat ggtggtggct ggggacagcc 300tcatggtggt ggctggggtc aaggaggtgg cacccacagt cagtggaaca agccgagtaa 360gccaaaaacc aacatgaagc acatggctgg tgctgcagca gctggggcag tggtgggggg 420ccttggcggc tacatgctgg gaagtgccat gagcaggccc atcatacatt tcggcagtga 480ctatgaggac cgttactatc gtgaaaacat gcaccgttac cccaaccaag tgtactacag 540gcccatggat gagtacagca accagaacaa ctttgtgcac gactgcgtca atatcacaat 600caagcagcac acggtcacca caaccaccaa gggggagaac ttcaccgaga ccgacgttaa 660gatgatggag cgcgtggttg agcagatgtg tatcacccag tacgagaggg aatctcaggc 720ctattaccag agaggatcga gcatggtcct cttctcctct ccacctgtga tcctcctgat 780ctctttcctc atcttcctga tagtgggatg aggaaggtct tcctgttttc accatctttc 840taatcttttt ccagcttgag ggaggcggta tccacctgca gcccttttag tggtggtgtc 900tcactctttc ttctctcttt gtcccggata ggctaatcaa tacccttggc actgatgggc 960actggaaaac atagagtaga cctgagatgc tggtcaagcc ccctttgatt gagttcatca 1020tgagccgttg ctaatgccag gccagtaaaa gtataacagc aaataaccat tggttaatct 1080ggacttattt ttggacttag tgcaacaggt tgaggctaaa acaaatctca gaacagtctg 1140aaataccttt gcctggatac ctctggctcc ttcagcagct agagctcagt atactaatgc 1200cctatcttag tagagatttc atagctattt agagatattt tccattttaa gaaaacccga 1260caacatttct gccaggtttg ttaggaggcc acatgatact tattcaaaaa aatcctagag 1320attcttagct cttgggatgc aggctcagcc cgctggagca tgagctctgt gtgtaccgag 1380aactggggtg atgttttact tttcacagta tgggctacac agcagctgtt caacaagagt 1440aaatattgtc acaacactga acctctggct agaggacata ttcacagtga acataactgt 1500aacatatatg aaaggcttct gggacttgaa atcaaatgtt tgggaatggt gcccttggag 1560gcaacctccc attttagatg tttaaaggac cctatatgtg gcattccttt ctttaaacta 1620taggtaatta aggcagctga aaagtaaatt gccttctaga cactgaaggc aaatctcctt 1680tgtccattta cctggaaacc agaatgattt tgacatacag gagagctgca gttgtgaaag 1740caccatcatc atagaggatg atgtaattaa aaaatggtca gtgtgcaaag aaaagaactg 1800cttgcatttc tttatttctg tctcataatt gtcaaaaacc agaattaggt caagttcata 1860gtttctgtaa ttggcttttg aatcaaagaa tagggagaca atctaaaaaa tatcttaggt 1920tggagatgac agaaatatga ttgatttgaa gtggaaaaag aaattctgtt aatgttaatt 1980aaagtaaaat tattccctga attgtttgat attgtcacct agcagatatg tattactttt 2040ctgcaatgtt attattggct tgcactttgt gagtatctat gtaaaaatat atatgtatat 2100aaaatatata ttgcatagga cagacttagg agttttgttt agagcagtta acatctgaag 2160tgtctaatgc attaactttt gtaaggtact gaatacttaa tatgtgggaa acccttttgc 2220gtggtcctta ggcttacaat gtgcactgaa tcgtttcatg taagaatcca aagtggacac 2280cattaacagg tctttgaaat atgcatgtac tttatatttt ctatatttgt aactttgcat 2340gttcttgttt tgttatataa aaaaattgta aatgtttaat atctgactga aattaaacga 2400gcgaagatga gcacc 2415 72 3869 DNA Homo sapiens 72aagcttggct ccagaactgg cttttgaagg tggaggtggg ggtagtgaga actgaaacag 60gctggctgga caactggcag cttggtgtgg ccttagaagc atgagtgagg gtggccggga 120gacgatttgt ctggactgtt gtgatttcac cctgactttt cctgccttca gcctctgcag 180agatgtgggc agctggtcag gatggccatt cgggctcagc acagcaacgc agcccagact 240cagactgggg aagcaaacag gggctggaca ggccaggaga gcctgtcgga cagtgatcct 300gagatgtggg agttgctgca gagggagaag gacaggcagt gtcgtggcct ggagctcatt 360gcctcagagg tgggactggg gagatgggca ggggttgggc caccatgggt acaggaagta 420acaaagttat cttaactgat atttctccaa aacccccttt cacactcagg acctttcttt 480gggctttatc ttcctttctt atctccctca agcaaaggca gtgcaagtcc agtttatggg 540gttgggacat ttagggagcc tccagggtcc ctacagtttc atctgatccc ttccttcctc 600ctatgaggaa ggaggagcct agaagcacaa gtttgagtgg gtaggtggca ttgaggggcc 660actgctcatg gcagatgggt ttctgagaat gctgcctctg gctttgcccc aggcctggtg 720ctgagtgaat ggagctttct gcagggagta ctcccgcttt cagctctggc tctggcaggg 780agggactgtg ggagtccagg ggaaggggct caataccttc tgacattgcc ccccaccacc 840ccagaacttc tgcagccgag ctgcgctgga ggccctgggg tcctgtctga acaacaagta 900ctcggagggt tatcctggca agaggtgagg gctggagggc agtgtcaggg atggtgctcc 960cagtggggga acccacctgt accttcccag tgttcattga ggagtgaact tcccagtcct 1020ttgctgatgg ttgagagtcc tttctctgtg ccctcattac ccctctccca cggcagatac 1080tatgggggag cagaggtggt ggatgaaatt gagctgctgt gccagcgccg ggccttggaa 1140gcctttgacc tggatcctgc acagtgggga gtcaatgtcc agccctactc cgggtcccca 1200gccaacctgg ccgtctacac agcccttctg caacctcacg accggatcat ggggctggac 1260ctgcccgatg ggggccagtg agtatggatg ggctggctga tggtcttggc ggcaggattg 1320gtgtgggaaa ggagttattt attgaatacc tactgtggac catacagatg gaacaggcct 1380tgccctgtcc tgcatgtcac agtggatgag gaagataaga tcccagttat agtgcctacc 1440acagagtgga cagagcagtg aggcggtgtg tcctaggact ggtgttctgg ggacagagaa 1500ctgtggagtt gaagggagtg gttaagtccg ggggtccttc cacccaggcc ttcttacttc 1560ctctcacttc gcagtctcac ccacggctac atgtctgacg tcaagcggat atcagccacg 1620tccatcttct tcgagtctat gccctataag ctcaacgtga gtgctctagg gtgtggggag 1680gggctcttgg ccctggtggt ggtcctcccc tggagaagct gagggcctgg agcgccgggc 1740cgtccttagg gttaaggagg agagtgagct gccctgcttc cttctcaggg ctttagctgt 1800ttgtgtgtct gtccagccca aaactggcct cattgactac aaccagctgg cactgactgc 1860tcgacttttc cggccacggc tcatcatagc tggcaccagc gcctatgctc gcctcattga 1920ctacgcccgc atgagagagg ttggtggggg gggctggaga ctgggcacct ccccaggggg 1980tggtgaggag gtgtgggagg agggcagcct tgggcaggcc tctccgggcc ctccccaggc 2040tgaggccttg cctctgtacc tgcccaggtg tgtgatgaag tcaaagcaca cctgctggca 2100gacatggccc acatcagtgg cctggtggct gccaaggtga ttccctcgcc tttcaagcac 2160gcggacatcg tcaccaccac tactcacaag actcttcgag gggccaggtc aggtcctgag 2220gtcgggcttg cctttccctg ccttcaggcc tattcctggg gcactgttgg cctggacctg 2280agaggaattc attcccacct gcagccctta agactcctgc ccagtctgtg agagttctcc 2340ttctcttgcc catggtggcc atgccctggc aggggatttg tggatgggat tgaggggctg 2400attccctcta ccactggaat ccagtgtacc aagcccacgt gagctgtgcc cttggggccc 2460aggtccgcca gcttcctctg ccttctctgt cccttgtcct tcttttcagc ttagactctg 2520accatccacc tctcacacag gtcagggctc atcttctacc ggaaaggggt gaaggctgtg 2580gaccccaaga ctggccggga gatcccttac acatttgagg accgaatcaa ctttgccgtg 2640ttcccatccc tgcagggggg cccccacaat catgccattg ctgcagtagc tgtggcccta 2700aagcaggttg gggatcctgt ctttgtaggg tgtggggggg caatggcctg gaggcttaga 2760ccctgcacct tgctaactga tgctggggct gatggaaggg aaatgccagg atggaaggag 2820tcaaggctgg ggtcacagag ctatgctgag ggtgcagggc cagagggtag tgcagggctt 2880gggtccaggc ctagggtgac agctgctact gtctcatctc caggcctgca cccccatgtt 2940ccgggagtac tccctgcagg ttctgaagaa tgctcgggcc atggcagatg ccctgctaga 3000gcgaggctac tcactggtat caggtaagcc agcaggtgat gggtgagggc ctctgtagct 3060tcaggcagag gcccaggact caccactccc catttcttac ccaccttagg tggtactgac 3120aaccacctgg tgctggtgga cctgcggccc aagggcctgg atggagctcg ggctgagcgg 3180gtgctagagc ttgtatccat cactgccaac aagaacacct gtcctggaga ccgaagtgcc 3240atcacaccgg gcggcctgcg gcttggggcc ccagccttaa cttctcgaca gttccgtgag 3300gatgacttcc ggagagttgt ggactttata gatgaagggg tcaacattgg cttagaggtg 3360aagagcaaga ctggtgagtg agcaagaagg agccccgggc cagccagttc ccactcactg 3420tctgctccct cccccagctg atctcactgc cttccctaga gctctgacca cttgtttcct 3480caccctctct ctctagccaa gctccaggat ttcaaatcct tcctgcttaa ggactcagaa 3540acaagtcagc gtctggccaa cctcaggcaa cgggtggagc agtttgccag ggccttcccc 3600atgcctggtt ttgatgagca ttgaaggcac ctgggaaatg aggcccacag actcaaagtt 3660actctccttc cccctacctg ggccagtgaa atagaaagcc tttctatttt ttggtgcggg 3720agggaagacc tctcacttag ggcaagagcc aggtatagtc tcccttccca gaatttgtaa 3780ctgagaagat cttttctttt tccttttttt ggtaacaaga cttagaagga gggcccaggc 3840actttctgtt tgaacccctg tcatgatca 3869 73 3344 DNA Homo sapiens 73ggtacagctg cgcgtctgcg ggaataggtg cagcgggccc ttggcggggg actctgaggg 60aggagctggg gacggcgacc ctaggagagt tctttggggt gactttcaag atggactcta 120ctctaacagc aagtgaaatc cggcagcgat ttatagattt cttcaagagg aacgagcata 180cgtatgttca ctcgtctgcc accatcccat tggatgaccc cactttgctc tttgccaatg 240caggcatgaa ccagtttaaa cccattttcc tgaacacaat tgacccatct caccccatgg 300caaagctgag cagagctgcc aatacccaga agtgcatccg ggctgggggc aaacaaaatg 360acctggacga tgtgggcaag gatgtctatc atcacacctt cttcgagatg ctgggctctt 420ggtcttttgg agattacttt aaggaattgg catgtaagat ggctctggaa ctcctcaccc 480aagagtttgg cattcccatt gaaagacttt atgttactta ctttggcggg gatgaagcag 540ctggcttaga agcagatctg gaatgcaaac agatctggca aaatttgggg ctggatgaca 600ccaaaatcct cccaggcaac atgaaggata acttctggga gatgggtgac acgggcccct 660gtggtccttg cagtgagatc cactacgacc ggattggtgg tcgggacgcc gcacatcttg 720tcaaccagga cgaccctaat gtgctggaga tctggaacct tgtgttcatc cagtataaca 780gggaagctga tggcattctg aaacctcttc ccaagaaaag cattgacaca gggatgggcc 840tggaacgact ggtatctgtg ctgcagaata agatgtccaa ctatgacact gacctttttg 900tcccttactt tgaagccatt cagaagggca caggtgcccg accatacact gggaaagttg 960gtgctgagga tgccgatggg attgacatgg cctaccgggt gctggctgac catgctcgga 1020ccatcactgt ggcactggct gatggtggcc ggcctgacaa cacagggcgt ggatatgtgt 1080tgagacggat tctccgccga gctgtccgat acgcccatga aaagctcaat gccagcaggg 1140gcttctttgc tacgttagtg gatgttgtcg tccagtccct gggagatgca tttcctgagc 1200tgaagaagga cccagacatg gtgaaggaca tcattaatga agaagaggtg cagtttctca 1260agactctcag cagagggcgt cgcatcctgg acaggaaaat tcagagcctg ggagacagca 1320agaccattcc cggagacact gcttggctcc tctatgacac ctatgggttt ccagtggatc 1380tgactggact gattgctgaa gagaagggcc tggtggtaga catggatggc tttgaagagg 1440agaggaaact ggcccagctg aaatcacagg gcaagggagc tggtggggaa gacctcatta 1500tgctggacat ttacgctatc gaagagctcc gggcacgggg tctggaggtc acagatgatt 1560ccccaaagta caattaccat ttggactcca gtggtagcta tgtatttgag aacacagtgg 1620ctacggtgat ggctctgcgc agggagaaga tgttcgtgga agaggtgtcc acaggccagg 1680agtgtggagt ggtgctggac aagacctgtt tctatgctga gcaaggaggc cagatctatg 1740acgaaggcta cctggtgaag gtggatgaca gcagtgaaga taaaacagag tttacagtga 1800agaatgctca ggtccgagga gggtatgtgc tacacattgg aaccatctac ggtgacctga 1860aagtggggga tcaggtctgg ctgtttattg atgagccccg acgaagaccc atcatgagca 1920accacacagc tacgcacatt ctgaacttcg ccctgcgctc agtgcttggg gaagctgacc 1980agaaaggctc attggttgct cctgaccgcc tcagatttga ctttactgcc aagggagcca 2040tgtccaccca acagatcaag aaggctgaag agattgctaa tgagatgatt gaggcagcca 2100aggccgtcta tacccaggat tgccccctgg cagcagcgaa agccatccag ggcctacggg 2160ctgtgtttga tgagacctat cctgaccctg tgcgagtcgt ctccattggg gtcccggtgt 2220ccgagttgct ggatgacccc tctgggcctg ctggctccct gacttctgtt gagttctgtg 2280ggggaacgca cctgcggaac tcgagtcatg caggagcttt tgtgatcgtg acggaagaag 2340ccattgccaa gggtatccgg aggattgtgg ctgtcacagg tgccgaggcc cagaaggccc 2400tcaggaaagc agagagcttg aagaaatgtc tctctgtcat ggaagccaaa gtgaaggctc 2460agactgctcc aaacaaggat gtgcagaggg agatcgctga ccttggagag gccctggcca 2520ctgcagtcat cccccagtgg cagaaggatg aattgcggga gactctcaaa tccctaaaga 2580aggtcatgga tgacttggac cgagccagca aagccgatgt ccagaaacga gtgttagaga 2640agacgaagca gttcatcgac agcaacccca accagcctct tgtcatcctg gagatggaga 2700gcggcgcctc agccaaggcc ctgaatgaag ccttgaagct cttcaagatg cactcccctc 2760agacttctgc catgctcttc acggtggaca atgaggctgg caagatcacg tgcctgtgtc 2820aagtccccca gaatgcagcc aatcggggct taaaagccag cgagtgggtg cagcaggtgt 2880caggcttgat ggacggtaaa ggtggtggca aggatgtgtc tgcacaggcc acaggcaaga 2940acgttggctg cctgcaggag gcgctgcagc tggccacttc cttcgcccag ctgcgcctcg 3000gggatgtaaa gaactgagtg gggaaggagg aggctcccac tggatccatc cgtccagcca 3060agagctcttc atctgctaca agaacatttg aatcttggga cctttaaaga gcccctccta 3120acccagcagt aactggaaca cacttgggag cagtcctatg tctcagtgcc ccttaaattt 3180ctgccctgag ccctccacgt cagtgccatc ggtctagaac cactaacccc gcattgctgt 3240tgatcgtcac gctcgcatct atagataacg gctctccaga cctgagcttt ccgcgtcagc 3300aagtaggaat cgtttttgct gcagagaata aaaggaccac gtgc 3344 74 1902 DNA Homo sapiens 74gcccctttct ttctcctcgt cggcccgaga gcaggaacac gataacgaag gaggcccaac 60ttcattcaat aaggagcctg acggatttat cccagacggt agaacaaaag gaagaatatt 120gatggatttt aaaccagagt ttttaaagag cttgagaata cggggaaatt aatttgttct 180cctacacaca tagatagggt aaggttgttt ctgatgcagc tgagaaaaat gcagaccgtc 240aaaaaggagc aggcgtctct tgatgccagt agcaatgtgg acaagatgat ggtccttaat 300tctgctttaa cggaagtgtc agaagactcc acaacaggtg aggacgtgct tctcagtgaa 360ggaagtgtgg ggaagaacaa atcttctgca tgtcggagga aacgggaatt cattcctgat 420gaaaagaaag atgctatgta ttgggaaaaa aggcggaaaa ataatgaagc tgccaaaaga 480tctcgtgaga agcgtcgact gaatgacctg gttttagaga acaaactaat tgcactggga 540gaagaaaacg ccactttaaa agctgagctg ctttcactaa aattaaagtt tggtttaatt 600agctccacag catatgctca agagattcag aaactcagta attctacagc tgtgtacttt 660caagattacc agacttccaa atccaatgtg agttcatttg tggacgagca cgaaccctcg 720atggtgtcaa gtagttgtat ttctgtcatt aaacactctc cacaaagctc gctgtccgat 780gtttcagaag tgtcctcagt agaacacacg caggagagct ctgtgcaggg aagctgcaga 840agtcctgaaa acaagttcca gattatcaag caagagccga tggaattaga gagctacaca 900agggagccaa gagatgaccg aggctcttac acagcgtcca tctatcaaaa ctatatgggg 960aattctttct ctgggtactc acactctccc ccactactgc aagtcaaccg atcctccagc 1020aactccccgg gaacgtcgga aactgatgat ggtgtggtag gaaagtcatc tgatggagaa 1080gacgagcaac aggtccccaa gggccccatc cattctccag ttgaactcaa gcatgtgcat 1140gcaactgtgg ttaaagttcc agaagtgaat tcctctgcct tgccacacaa gctccggatc 1200aaagccaaag ccatgcagat caaagtagaa gcctttgata atgaatttga ggccacgcaa 1260aaactttcct cacctattga catgacatct aaaagacatt tcgaactcga aaagcatagt 1320gccccaagta tggtacattc ttctcttact cctttctcag tgcaagtgac taacattcaa 1380gattggtctc tcaaatcgga gcactggcat caaaaagaac tgagtggcaa aactcagaat 1440agtttcaaaa ctggagttgt tgaaatgaaa gacagtggct acaaagtttc tgacccagag 1500aacttgtatt tgaagcaggg gatagcaaac ttatctgcag aggttgtctc actcaagaga 1560cttatagcca cacaaccaat ctctgcttca gactctgggt aaattactac tgagtaagag 1620ctgggcattt agaaagatgt catttgcaat agagcagtcc attttgtatt atgctgaatt 1680ttcactggac ctgtgatgtc atttcactgt gatgtgcaca tgttgtctgt ttggtgtctt 1740tttgtgcaca gattatgatg aagattagat tgtgttatca ctctgcctgt gtatagtcag 1800atagtccatg cgaaggctgt atatattgaa cattattttt gttgttctat tataaagtgt 1860gtaagttacc agtttcaata aaggattggt gacaaacaca ga 1902 75 1560 DNA Homo sapiens 75ctccataagg cacaaacttt cagagacagc agagcacaca agcttctagg acaagagcca 60ggaagaaacc accggaagga accatctcac tgtgtgtaaa catgacttcc aagctggccg 120tggctctctt ggcagccttc ctgatttctg cagctctgtg tgaaggtgca gttttgccaa 180ggagtgctaa agaacttaga tgtcagtgca taaagacata ctccaaacct ttccacccca 240aatttatcaa agaactgaga gtgattgaga gtggaccaca ctgcgccaac acagaaatta 300ttgtaaagct ttctgatgga agagagctct gtctggaccc caaggaaaac tgggtgcaga 360gggttgtgga gaagtttttg aagagggctg agaattcata aaaaaattca ttctctgtgg 420tatccaagaa tcagtgaaga tgccagtgaa acttcaagca aatctacttc aacacttcat 480gtattgtgtg ggtctgttgt agggttgcca gatgcaatac aagattcctg gttaaatttg 540aatttcagta aacaatgaat agtttttcat tgtaccatga aatatccaga acatacttat 600atgtaaagta ttatttattt gaatctacaa aaaacaacaa ataattttta aatataagga 660ttttcctaga tattgcacgg gagaatatac aaatagcaaa attgggccaa gggccaagag 720aatatccgaa ctttaatttc aggaattgaa tgggtttgct agaatgtgat atttgaagca 780tcacataaaa atgatgggac aataaatttt gccataaagt caaatttagc tggaaatcct 840ggattttttt ctgttaaatc tggcaaccct agtctgctag ccaggatcca caagtccttg 900ttccactgtg ccttggtttc tcctttattt ctaagtggaa aaagtattag ccaccatctt 960acctcacagt gatgttgtga ggacatgtgg aagcacttta agttttttca tcataacata 1020aattattttc aagtgtaact tattaaccta tttattattt atgtatttat ttaagcatca 1080aatatttgtg caagaatttg gaaaaataga agatgaatca ttgattgaat agttataaag 1140atgttatagt aaatttattt tattttagat attaaatgat gttttattag ataaatttca 1200atcagggttt ttagattaaa caaacaaaca attgggtacc cagttaaatt ttcatttcag 1260atatacaaca aataattttt tagtataagt acattattgt ttatctgaaa ttttaattga 1320actaacaatc ctagtttgat actcccagtc ttgtcattgc cagctgtgtt ggtagtgctg 1380tgttgaatta cggaataatg agttagaact attaaaacag ccaaaactcc acagtcaata 1440ttagtaattt cttgctggtt gaaacttgtt tattatgtac aaatagattc ttataatatt 1500atttaaatga ctgcattttt aaatacaagg ctttatattt ttaactttaa aaaaaaccgg 1560 76 642 DNA Homo sapiens 76tcgtgttcat gggagctcgt tttcttttcc tctaggcaga gaagaggcga tggcggcgat 60ggcatctctc ggcgccctgg cgctgctcct gctgtccagc ctctcccgct gctcagccga 120ggcctgcctg gagccccaga tcaccccttc ctactacacc acttctgacg ctgtcatttc 180cactgagacc gtcttcattg tggagatctc cctgacatgc aagaacaggg tccagaacat 240ggctctctat gctgacgtcg gtggaaaaca attccctgtc actcgaggcc aggatgtggg 300gcgttatcag gtgtcctgga gcctggacca caagagcgcc cacgcaggca cctatgaggt 360tagattcttc gacgaggagt cctacagcct cctcaggaag gctcagagga ataacgagga 420catttccatc atcccgcctc tgtttacagt cagcgtggac catcggggca cttggaacgg 480gccctgggtg tccactgagg tgctggctgc ggcgatcggc cttgtgatct actacttggc 540cttcagtgcg aagagccaca tccaggcctg agggcggcac cccagccctg cccttgcttc 600cttcaataaa catcacagga cctgggactg cacaggaaaa aa 642 77 2647 DNA Homo sapiens 77gccgcgctgg tggcggcggc gcgtcgttgc agttgcgcca tctgtcagga gcggagccgg 60cgaggagggg gctgccgcgg gcgaggagga ggggtcgccg cgagccgaag gccttcgaga 120cccgcccgcc gcccggcggc gagagtagag gcgaggttgt tgtgcgagcg gcgcgtcctc 180tcccgcccgg gcgcgccgcg cttctcccag cgcaccgagg accgcccggg cgcacacaaa 240gccgccgccc gcgccgcacc gcccggcggc cgccgcccgc gccagggagg gattcggccg 300ccgggccggg gacaccccgg cgccgccccc tcggtgctct cggaaggccc accggctccc 360gggcccgccg gggacccccc ggagccgcct cggccgcgcc ggaggagggc ggggagagga 420ccatgtgagt gggctccgga gcctcagcgc cgcgcagttt ttttgaagaa gcaggatgct 480gatctaaacg tggaaaaaga ccagtcctgc ctctgttgta gaagacatgt ggtgtatata 540aagtttgtga tcgttggcgg aaattttgga atttagataa tgggctgtgt gcaatgtaag 600gataaagaag caacaaaact gacggaggag agggacggca gcctgaacca gagctctggg 660taccgctatg gcacagaccc cacccctcag cactacccca gcttcggtgt gacctccatc 720cccaactaca acaacttcca cgcagccggg ggccaaggac tcaccgtctt tggaggtgtg 780aactcttcgt ctcatacggg gaccttgcgt acgagaggag gaacaggagt gacactcttt 840gtggcccttt atgactatga agcacggaca gaagatgacc tgagttttca caaaggagaa 900aaatttcaaa tattgaacag ctcggaagga gattggtggg aagcccgctc cttgacaact 960ggagagacag gttacattcc cagcaattat gtggctccag ttgactctat ccaggcagaa 1020gagtggtact ttggaaaact tggccgaaaa gatgctgagc gacagctatt gtcctttgga 1080aacccaagag gtacctttct tatccgcgag agtgaaacca ccaaaggtgc ctattcactt 1140tctatccgtg attgggatga tatgaaagga gaccatgtca aacattataa aattcgcaaa 1200cttgacaatg gtggatacta cattaccacc cgggcccagt ttgaaacact tcagcagctt 1260gtacaacatt actcagagag agctgcaggt ctctgctgcc gcctagtagt tccctgtcac 1320aaagggatgc caaggcttac cgatctgtct gtcaaaacca aagatgtctg ggaaatccct 1380cgagaatccc tgcagttgat caagagactg ggaaatgggc agtttgggga agtatggatg 1440ggtacctgga atggaaacac aaaagtagcc ataaagactc ttaaaccagg cacaatgtcc 1500cccgaatcat tccttgagga agcgcagatc atgaagaagc tgaagcacga caagctggtc 1560cagctctatg cagtggtgtc tgaggagccc atctacatcg tcaccgagta tatgaacaaa 1620ggaagtttac tggatttctt aaaagatgga gaaggaagag ctctgaaatt accaaatctt 1680gtggacatgg cagcacaggt ggctgcagga atggcttaca tcgagcgcat gaattatatc 1740catagagatc tgcgatcagc aaacattcta gtggggaatg gactcatatg caagattgct 1800gacttcggat tggcccgatt gatagaagac aatgagtaca cagcaagaca aggtgcaaag 1860ttccccatca agtggacggc ccccgaggca gccctgtacg ggaggttcac aatcaagtct 1920gacgtgtggt cttttggaat cttactcaca gagctggtca ccaaaggaag agtgccatac 1980ccaggcatga acaaccggga ggtgctggag caggtggagc gaggctacag gatgccctgc 2040ccgcaggact gccccatctc tctgcatgag ctcatgatcc actgctggaa aaaggaccct 2100gaagaacgcc ccacttttga gtacttgcag agcttcctgg aagactactt taccgcgaca 2160gagccccagt accaacctgg tgaaaacctg taaggcccgg gtctgcggag agaggccttg 2220tcccagaggc tgccccaccc ctccccatta gctttcaatt ccgtagccag ctgctcccca 2280gcagcggaac cgcccaggat cagattgcat gtgactctga agctgacgaa cttccatggc 2340cctcattaat gacacttgtc cccaaatccg aacctcctct gtgaagcatt cgagacagaa 2400ccttgttatt tctcagactt tggaaaatgc attgtatcga tgttatgtaa aaggccaaac 2460ctctgttcag tgtaaatagt tactccagtg ccaacaatcc tagtgctttc cttttttaaa 2520aatgcaaatc ctatgtgatt ttaactctgt cttcacctga ttcaactaaa aaaaaaaagt 2580attattttcc aaaagtggcc tctttgtcta aaacaataaa attttttttc atgttttaac 2640aaaaacc 2647 78 1826 DNA Homo sapiens 78tacctgaccc cagccatttc ccttctagaa attgttctac agacatatgt aataacatat 60acaaaaggtt attctttcag cagtgtttgt cagagcgaga acattccaga gagctgttgc 120gcagccattg gtacctgtat tggggaaaca tagcatacaa tcaagaagct tacagcctca 180gtggcgaaaa ttttttcatg tcagagaccg agaactcttg cagtcgttta tgtcatccct 240tcttctccag acagaagata ccaaaaagtt gcaatcaaag atctcttcat cttattgata 300aagccactaa taagccaaaa tgtctgtcaa tgtcaaccgc agcgtgtcag accagttcta 360tcgctacaag atgccccgtc tgattgccaa ggttgagggc aaaggcaatg gaatcaagac 420agttatagtc aacatggttg acgttgcaaa ggcgcttaat cggcctccaa cgtatcccac 480caaatatttt ggttgtgagc tgggagcaca gacccagttt gatgttaaga atgaccgtta 540cattgtcaat ggatctcatg aggcgaataa gctgcaagac atgttggatg gattcattaa 600aaaatttgtt ctctgtcctg aatgtgagaa tcctgaaaca gatttgcatg tcaatccaaa 660gaagcaaaca ataggtaatt cttgtaaagc ctgtggctat cgaggcatgc ttgacacaca 720tcataaactc tgcacattca ttctcaaaaa cccacctgag aatagtgaca gtggtacagg 780aaagaaagaa aaagaaaaga aaaacagaaa gggcaaagac aaggaaaatg gctccgtatc 840cagcagtgag acaccaccac caccaccacc accaaatgaa attaatcctc ctccacatac 900aatggaagaa gaggaggatg atgactcggg agaagataca actgaggaag ctcaaaggcg 960tcgaatggat gaaatcagtg accatgcaaa agttctgaca ctcagtgatg atttggaaag 1020aacaattgag gagagggtca atatcctctt tgattttgtt aagaaaaaga aagaagaggg 1080tgttattgat tcatctgaca aagaaatcgt tgctgaagca gaaagactgg atgtaaaagc 1140catgggccct cttgttctaa ctgaagttct ttttaatgag aagattagag aacagattaa 1200gaaatacagg cgccatttcc tacgattttg tcacaacaac aaaaaagccc aacggtacct 1260tcttcatggt ttggagtgtg tggtagcaat gcatcaagct cagcttatct ccaagattcc 1320acatatcttg aaggagatgt acgatgcaga ccttttagaa gaagaggtca tcatcagctg 1380gtcggaaaag gcctctaaga aatatgtctc caaagaactt gccaaagaga ttcgtgtcaa 1440agcagaacca tttataaaat ggttgaagga ggcagaggaa gaatcttctg gtggcgaaga 1500agaagatgaa gatgagaaca ttgaggtggt gtattcgaag gctgccagtg taccgaaagt 1560tgagactgta aagtcagaca acaaggatga cgacatcgat attgatgcca tttaaaggga 1620tggatgcaac ctagcttaac agtataatgc tgcaaatttt cctccattat cagccagaag 1680tgcaacatgt atgtgcaaaa gctaaaatgg cttaacatca tgctacactt tacactaaaa 1740atctattact gtgagtgtga aaaactagtg gtggacacat ttggatcaca tttatacagt 1800tataaaaata aaggtttgat tttggt 1826 79 5857 DNA Homo sapiens 79cggcgcaggc ggcggcgtcc gaggagattt aatccagaga ctgacttcac tatagaaccc 60acagttgtat caatggttgg ggaaagatag tggcaacagg caaaggagaa acagctctga 120catacaaaga aaatgagtat gctaaagcca agtgggctta aggcccccac caagatcctg 180aagcctggaa gcacagctct gaagacacct acggctgttg tagctccagt agaaaaaacc 240atatccagtg aaaaagcatc aagcactcca tcatctgaga ctcaggagga atttgtggat 300gactttcgag ttggggagcg agtttgggtg aatggaaata agcctggatt tatccagttt 360cttggagaaa cccagtttgc accaggccag tgggctggaa ttgttttaga tgaacccata 420ggcaagaacg atggttcggt ggcaggagtt cggtatttcc agtgtgaacc tttaaagggc 480atatttaccc gaccttcaaa gttaacaagg aaggtgcaag cagaagatga agctaatggc 540ctgcagacaa cgcccgcctc ccgagctact tcaccgctgt gcacttctac ggccagcatg 600gtgtcttcct ccccctccac cccttcaaac atccctcaga aaccatcaca gccagcagca 660aaggaacctt cagctacgcc tccgatcagc aaccttacaa aaactgccag tgaatctatc 720tccaaccttt cagaggctgg ctcaatcaag aaaggagaaa gagagctcaa aatcggagac 780agagtattgg ttggtggcac taaggctggt gtagtccggt ttcttgggga gaccgacttt 840gccaaggggg agtggtgtgg cgtggagtta gatgagccac ttgggaagaa tgatggcgct 900gttgctggaa caaggtattt tcagtgtcaa cccaaatatg gcttgttcgc tcctgtccac 960aaagttacca agattggctt cccttccact acaccagcca aagccaaggc caacgcagtg 1020aggcgagtga tggcgaccac gtccgccagc ctgaagcgca gcccttctgc ctcttccctc 1080agctccatga gctcagtggc ctcctctgtg agcagcaggc ccagtcggac aggactattg 1140actgaaacct cctcccgtta cgccaggaag atctccggta ccactgccct ccaggaggcc 1200ctgaaggaga agcagcagca cattgagcag ctgctggcgg aacgggatct ggagagggcg 1260gaggtggcca aggccacgag ccacgtgggg gagatagagc aggagctagc tctggcccgg 1320gacggacatg accagcatgt cctggaattg gaagccaaaa tggaccagct gcgaacaatg 1380gtggaagctg ctgacaggga gaaggtggag cttctcaacc agcttgaaga ggagaaaagg 1440aaggttgagg accttcagtt ccgggttgaa gaagaatcaa ttaccaaagg tgatcttgag 1500acgcagacca aactggagca tgcccgcatt aaggagcttg aacagagcct gctctttgaa 1560aagaccaaag ctgacaaact ccagagggag ttagaagaca ctagggtggc tacagtttca 1620gaaaagtcac gtataatgga actggagaaa gacctagcat tgagagtaca ggaagtagct 1680gagctccgaa gaaggctaga gtccaataag cctgctgggg atgtggacat gtcactttcc 1740cttttgcaag agataagctc tttgcaagaa aagttagaag tcacccgtac tgaccaccag 1800agagaaataa cttctctgaa ggagcatttt ggagcccggg aagaaactca tcagaaggag 1860ataaaggctc tgtataccgc cacggaaaag ctttccaaag agaacgagtc attgaaaagc 1920aagctggagc atgccaacaa agagaactca gatgtgatag ctctatggaa gtccaaactg 1980gagactgcca tcgcatccca ccagcaggcg atggaagaac tgaaggtatc tttcagcaaa 2040gggcttggaa cagagacggc agaatttgct gaactaaaaa cacaaataga gaaaatgaga 2100ctagattacc aacacgaaat agaaaatttg cagaatcaac aagactctga acgggctgcc 2160catgctaaag agatggaagc cttgagggct aaactgatga aagttattaa agaaaaggaa 2220aacagtctgg aagccatcag gtcgaaactg gacaaagcag aagaccagca tctcgtagaa 2280atggaagaca cgttaaacaa attacaggaa gctgaaataa aggtaaagga gctagaggta 2340ctgcaagcca aatgcaatga acaaaccaag gttattgata attttacatc acagctcaag 2400gctactgaag aaaagctctt ggatcttgat gcacttcgga aagccagttc cgaaggtaaa 2460tcggaaatga agaaacttag acagcagctt gaggcagctg agaaacagat taaacattta 2520gagattgaaa agaatgctga aagtagcaag gctagtagca ttaccagaga gctccagggg 2580agagagctaa agcttactaa ccttcaggaa aatttgagtg aagtcagtca agtgaaagag 2640actttggaaa aagaacttca gattttgaaa gaaaagtttg ctgaagcttc agaggaggca 2700gtctctgttc agagaagtat gcaagaaact gtaaataagt tacaccaaaa ggaggaacag 2760tttaacatgc tgtcttctga cttggagaag ctgagagaaa acttagcaga tatggaggca 2820aaatttagag agaaagatga gagagaagag cagctgataa aggcaaagga aaaactggaa 2880aatgacattg cagaaataat gaagatgtca ggagataact cttctcagct gacaaaaatg 2940aacgatgaat tacgtctgaa agaaagagat gtagaagaat tacagctaaa acttacaaag 3000gctaatgaaa atgcaagttt tctgcaaaaa agtattgagg acatgactgt caaagctgaa 3060cagagccagc aagaagcagc taaaaagcat gaggaagaaa agaaagaatt ggagaggaaa 3120ttgtcggacc tggaaaagaa aatggaaaca agccacaacc agtgtcagga gctgaaagcc 3180aggtatgaga gagccacttc tgagacaaaa accaagcatg aagaaatcct acagaacctc 3240cagaagacgc tgctggacac agaggacaag ctgaagggcg cacgggagga gaacagtggc 3300ttgctgcagg agctggagga gctgagaaag caagccgaca aagccaaagc tgctcaaaca 3360gcggaagatg ccatgcagat aatggaacag atgaccaaag agaagactga gactctggcc 3420tccttggagg acaccaagca aacaaatgca aaactacaga atgaattgga cacacttaaa 3480gaaaacaact tgaaaaatgt ggaagagctg aacaaatcaa aagaactcct gactgtagag 3540aatcaaaaaa tggaagaatt taggaaagaa atagaaaccc taaagcaggc agcagctcag 3600aagtcccagc agctttcagc gttgcaagaa gagaacgtta aacttgctga ggagctgggg 3660agaagcaggg acgaagtcac aagtcatcaa aagctggaag aagaaagatc tgtgctcaat 3720aatcagttgt tagaaatgaa aaaaagagaa tccaagttca taaaagacgc agatgaagag 3780aaagcttcct tgcagaaatc catcagtata actagtgcct tactcacaga aaaggatgcc 3840gagctggaga aactgagaaa tgaggtcaca gtgctcaggg gagaaaacgc ctctgccaag 3900tccttgcatt cagttgttca gactctagag tctgataagg tgaagctcga gctcaaggta 3960aagaacttgg agcttcaact caaagaaaac aagaggcagc tcagcagctc ctcaggtaat 4020acagacactc aggcagacga ggatgaaaga gcccaggaga gtcagattga tttcctaaat 4080tcagtaatag tggaccttca aaggaagaat caagacctca agatgaaggt ggagatgatg 4140tcagaagcag ccctgaatgg gaacggggat gacctaaaca attatgacag tgatgatcag 4200gagaaacagt ccaagaagaa acctcgcctc ttctgtgaca tttgtgactg ctttgatctc 4260cacgacacag aggattgtcc tacccaggca cagatgtcag aggaccctcc ccattccaca 4320caccatggca gtcggggtga ggaacgccca tactgtgaaa tctgtgagat gtttggacac 4380tgggccacca actgcaatga cgacgaaacc ttctgatgaa gcctccagtg gagaactggg 4440cttgctcaga cgcactcgca ttgacacaac gtaacaccag cattgtgtgt gcagacttca 4500ggagaactca tgttattttt taaccccgtc aacaaatcta ggaaaatatt ttgatcttca 4560acaaattgcc ctttagtctc cccgtatgag ttagaataat aaatatttag taggtgagtt 4620ttcacctcga attttgtttt cttgattttt acgtttgaag acattgcacc agatgccatt 4680acatttattg gccccccgac cttgtagaaa aacccctacc ctcacaatac cttatttaag 4740taactttaaa ttatgccgtt acttttcata tttgcaccta agatatttcc aggctgcatt 4800tgtatattta gattttttgg ttaagctttg acactggaat gagttgaaaa aatgtgccat 4860tttgcatttt catctactca tttaaagtat tttattctta ttcaaagaaa tatctgagct 4920ctttgcacta cctgttatca gtagtgcctt tacttcaggc ttgataatac ttaggtgtga 4980ttataaaatc atgaagcagg taaagggagg ggcaagcccc aaactgctgt ggggacattt 5040tataatctat atgctgcacc cacttaatct actgtggtgt tttgtttatt agttttgcat 5100aatttcagct tctatatatt gtatgtatat attttttaaa aatctatatt ttgggaaaaa 5160aacatacaca atgtgtcttt ctttttggac atttaccttt ttgaaaaaga aaacacttaa 5220aatgatcatt aggacataac agactaggcc agacatagca tcttgtggct ttgcaaccat 5280tttcatttgt ttgttttcct tttatttctt caccagattt aaataaaagg aggaattttc 5340tccaattttt ttttccttct ctggcaggta tccccagcag tcaattaaca ataagccagt 5400ataaaacacc taaataacca atctacaatc tcccttcaca agttttttta ctgtttttag 5460atgaatgtac gatgagaaat tcaacgttaa taattctgga ttttcttatc acaaaaaaga 5520aaatgaagga cctcaaagca cctgaacagt ttatcgacca gtttgaatct atttatcttc 5580atttgaatgt cttctagata tgtaaaaagt cataaaatgt atcttccatg ctacatgtac 5640aataagaact tctataattg tatatatgcc tttgatgtat tttcccctca agattatcaa 5700ctgtgtgttc gacagtgaat attcaatctg gtaccagttg aaatttttgg ttataaatgt 5760aatacgaatt gtttcacaaa cagaaaacat gtaaagcagt attaaaattt ggccaaacaa 5820gtgttctgta tctactttta ataaatggtt attcttt 5857 80 2634 DNA Homo sapiens 80gccgccgccg ccgccgccgc cgcgggcttc gttcgtaagg aagggggcct aggccgggcc 60tgcggtggtg ggggttgctg cgcgccgggg gtcgctcctg ctgtgtcttc cgctccagct 120tcgcccactt ccccttacca gcggggtggg cgcggagaag acctgccgga gccatggagg 180acgaagtggt ccgctttgcc aagaagatgg acaagatggt gcagaagaag aacgcggctg 240gagcattgga tttgctaaag gagcttaaga atattcctat gaccctggaa ttactgcagt 300ccacaagaat cggaatgtca gttaatgcta ttcgcaagca gagtacagat gaggaagtta 360catctttggc aaagtctctc atcaaatcct ggaaaaaatt attagatggg ccatcaactg 420agaaagacct tgacgaaaag aagaaagaac ctgcaattac atcgcagaac agccctgagg 480caagagaaga aagtacttcc agcggcaatg taagcaacag aaaggatgag acaaatgctc 540gagatactta tctttcatcc tttcctcggg caccaagcac ttctgattct gtgcggttga 600agtgtaggga gatgcttgct gcagctcttc gaacagggga tgactacatt gcaattggag 660ctgatgagga agaattagga tctcaaattg aagaagctat atatcaagaa ataaggaata 720cagacatgaa atacaaaaat agagtacgaa gtaggatatc aaatcttaaa gatgcaaaaa 780atccaaattt aaggaaaaat gtcctctgtg ggaatattcc tcctgactta tttgctagaa 840tgacagcaga ggaaatggct agtgatgagc tgaaagagat gcggaaaaac ttgaccaaag 900aagccatcag agagcatcag atggccaaga ctggtgggac ccagactgac ttgttcacat 960gtggcaaatg taaaaagaag aattgcactt acacacaggt acaaacccgt agtgctgatg 1020aaccaatgac aacatttgtt gtctgtaatg aatgtggaaa tcgatggaag ttctgttgag 1080ttggaagaat tggcaaaata tctggaccat taagaaaacg gattttgtaa ctagctttaa 1140actaggccaa gcaactagtt ttcctgcaaa tcaaattttt aaagcaactt gggttagact 1200ttgtttttga cctaacatcc cttccttaaa tgccttctgt agtttcagat cagtagggag 1260accatataat aattgtatgg tacctgtttc aaaacatatt ttttctgttt ttataagtaa 1320gttgatatta attaaactct tggcaatatt tcttctttct taaaggaaaa tataccttaa 1380ctttttttct tttacactgt gaaacataca cagtagaaat tctgttactc tctgttatta 1440atacataaat gaaaatacat ttttttccat attggcatgt agctacaaat attaaaggag 1500gagaaaaggt aatataattt taggtttacc aaatatggtg tgtattcaaa taatacttga 1560ccagcttatc taaaatgtac ataattttga ggtagcttat gaatttgatt ttaattatta 1620tgttcacaag cttggaatat tagatattat tttgcatctg taactaaccg tgatcatcat 1680ttcttgtaat ttcttgtaca tgtatattac ttgttcttaa tagatttttg gaaacaagac 1740tttattgaga tcagtttggt tttcctgtta atttacctgt ttgactttat aatgtgtttt 1800agttttgcag aagaacactg ttgtagttta gaaggctttt cataaatccc ctcataggca 1860aagatgaaaa cttcccacta tttttttccc ctcttaggaa gacatactgg aaagaaaatg 1920tttagcatct tagtgtagta tagctattgt aaacagttca tgactagatt ttgattcgga 1980aatctatact gaccaaggat taatcttaag gattgtataa ttcattaaag ctgtggtctt 2040tccatgtgga gactgataga aaataatttt gtcccaagtc ttatttgctg actttttctg 2100tcatgagtga gattgttgaa caaactgaat atatgggcta tagcaagtag ctttacagta 2160cagatcttac aattaagttt tgcttttgtt aaagtgtgta ccattttttc tgtttggagt 2220aagacaaaaa ttgttttgac ataggttccc tagggtacac ttgctctagc atactttaaa 2280ggccactgtt gcaaagtcta cattttatgc tgaatctgca ttctgtcagg cacccataga 2340aagacctcag tacatgcttt gcactctcct ttgctccctt tttccaattt cttattgcat 2400atcattttgt tgtaatacag aaagcagcat ttttaaatgt ccgtgttaag aattggcccg 2460ctggtaccaa ctcacctcta ttttgtcagt tcatagttga agattttgtt ttatttcaaa 2520aagaaagtac atttttgaaa taatgtttca gaataaaata atctcacttt taagtgatcc 2580attttaaaat ttgtaattca ataaagtttt ttttgttgtt aaacataaaa aaaa 2634 81 351 DNA Homo sapiens misc_feature (1)...(351) n = A,T,C or G 81caatctgctt ccnctaatat anccccagtc taaggcattt aaaattaaac agctcttcaa 60cgccccaagt tattncatca ggctaagaac ttctccgaga aacgcacaag anggcaggca 120aacaggtggg taggtgagag gtcacggggc tccatctgca agctccatct acaaggcatc 180aatctgcgtt gtggcatcaa cgttaaaatg ttctacagct tagggatctt cttgaagcaa 240ggttccaagc acaaaactag gtatgaccgg aggcttcaat ttagaagatg cagcatctga 300aaacctttac cccgggnaag gaggggtgcc tgctggcatt tcatggggct c 351 82 1682 DNA Homo sapiens 82atgctcagtc ctccaggcgt cggtgctcag cggtgttgga acttcgttgc ttgcttgcct 60gtgcgcgcgt gcgcggacat ggcctcaaac gattataccc aacaagcaac ccaaagctat 120ggggcctacc ccacccagcc cgggcagggc tattcccagc agagcagtca gccctacgga 180cagcagagtt acagtggtta tagccagtcc acggacactt caggctatgg ccagagcagc 240tattcttctt atggccagag ccagaacaca ggctatggaa ctcagtcaac tccccaggga 300tatggctcga ctggcggcta tggcagtagc cagagctccc aatcgtctta cgggcagcag 360tcctcctacc ctggctatgg ccagcagcca gctcccagca gcacctcggg aagttacggt 420agcagttctc agagcagcag ctatgggcag ccccagagtg ggagctacag ccagcagcct 480agctatggtg gacagcagca aagctatgga cagcagcaaa gctataatcc ccctcagggc 540tatggacagc agaaccagta caacagcagc agtggtggtg gaggtggagg tggaggtgga 600ggtaactatg gccaagatca atcctccatg agtagtggtg gtggcagtgg tggcggttat 660ggcaatcaag accagagtgg tggaggtggc agcggtggct atggacagca ggaccgtgga 720ggccgcggca ggggtggcag tggtggcggc ggcggcggcg gcggtggtgg ttacaaccgc 780agcagtggtg gctatgaacc cagaggtcgt ggaggtggcc gtggaggcag aggtggcatg 840ggcggaagtg accgtggtgg cttcaataaa tttggtgtgt tcaagaagga agtgtatctt 900catacatcac cacacctgaa agcagatgtg cttttccaga ctgatccaac tgcagagatg 960gcagctgagt cattgccttt ctccttcggg acactgtcca gctgggagct ggaagcctgg 1020tatgaggacc tgcaagaggt cctgtcttca gatgaaaatg ggggtaccta tgtttcacct 1080cctggaaatg aagaggaaga atcaaaaatc ttcaccactc ttgaccctgc ttctctggct 1140tggctgactg aggaggagcc agaaccagca gaggtcacaa gcacctccca gagccctcac 1200tctccagatt ccagtcagag ctccctggct caggaggaag aggaggaaga ccaagggaga 1260accaggaaac ggaaacagag tggtcattcc ccagcccggg ctggaaagca gcgcatgaag 1320gagaaagaac aggagaatga aaggaaagtg gcacagctag ctgaagagaa tgaacggctc 1380aagcaggaaa tcgagcgcct gaccagggaa gtagaggcga ctcgccgagc tctgattgac 1440cgaatggtga atctgcacca agcatgaaca attgggagca tcagtccccc acttgggcca 1500cactacccac ctttcccaga agtggctact gactaccctc tcactagtgc caatgatgtg 1560accctcaatc ccacatacgc agggggaagg cttggagtag acaaaaggaa aggtctcagc 1620ttgtatatag agattgtaca tttatttatt actgtcccta tctattaaag tgactttcta 1680tg 1682 83 1791 DNA Homo sapiens 83ggcggacgga gcgagccctg ggcgagtgaa ttgtggctgt gggttgacgg tggagacacc 60ccccggagag gcggagggaa gggaggcgag gctgcacctg catgcttccc gcctcccact 120ccccagcgcc cccggaccgt gcagttctct gcaggaccag gccatggagc tcgaagtccg 180gcgggtccga caggcgttcc tgtccggccg gtcgcgacct ctgcggtttc ggctgcagca 240gctggaggcc ctgcggagga tggtgcagga gcgcgagaag gatatcctga cggccatcgc 300cgccgacctg tgcaagagtg aattcaatgt gtacagtcag gaagtcatta ctgtccttgg 360ggaaattgat tttatgcttg agaatcttcc tgaatgggtt actgctaaac cagttaagaa 420gaacgtgctc accatgctgg atgaggccta tattcagcca cagcctctgg gagtggtgct 480gataatcgga gcttggaatt accccttcgt tctcaccatt cagccactga taggagccat 540cgctgcagga aatgctgtga ttataaagcc ttctgaactg agtgaaaata cagccaagat 600cttggcaaag cttctccctc agtatttaga ccaggatctc tatattgtta ttaatggtgg 660tgttgaggaa accacggagc tcctgaagca gcgatttgac cacattttct atacgggaaa 720cactgcggtt ggcaaaattg tcatggaagc tgctgccaag catctgaccc ctgtgactct 780tgaactggga gggaaaagtc catgttatat tgataaagat tgtgacctgg acattgtttg 840cagacgcata acctggggaa aatacatgaa ttgtggccaa acctgcattg cacccgacta 900tattctctgt gaagcatccc tccaaaatca aattgtatgg aagattaagg aaacagtgaa 960ggaattttat ggagaaaata taaaagagtc tcctgattat gaaaggatca tcaatcttcg 1020tcattttaag aggatactaa gtttgcttga aggacaaaag atagcttttg gtggggagac 1080tgatgaggcc acacgctaca tagccccaac agtacttacc gatgttgatc ctaaaaccaa 1140ggtgatgcaa gaagaaattt ttggaccaat tcttccaata gtgcctgtga aaaatgtaga 1200tgaggccata aatttcataa atgaacgtga aaagcctctg gctctttatg tattttcgca 1260taaccataag ctcatcaaac ggatgattga tgagacatcc agtggaggtg tcacaggcaa 1320tgacgtcatt atgcacttca cgctcaactc tttcccattt ggaggagtgg gttccagtgg 1380gatgggagct tatcacggaa aacatagttt tgatactttt tctcatcagc gtccctgttt 1440attaaaaagt ttaaagagag aaggtgctaa caaactcaga tatcctccca acagccagtc 1500aaaggtggat tgggggaaat tttttctctt gaaacggttc aacaaagaaa aactcggtct 1560cctgttgctc actttcctgg gtattgtagc cgctgtgctt gtcaaggcag aatattactg 1620aagaatgatc ctgttcaacc tcctagtgcc tctactgaat tattcctctt ttaaatggtt 1680aatgaaccaa taatttttaa atcataccaa aaatagtaag aaaatatgca aacactctgt 1740gatcaaactt aaaagtcatt gccattcatc attaataaaa gttgccattt c 1791 84 3520 DNA Homo sapiens 84tctagagaag ccaatcagtg tcgccggggt cccagttcta aagtccccac gcacccaccc 60ggactcagaa tctcctcaga cgccgagatg cgggtcacgg cgccccgaac cgtcctcctg 120ctgctctggg gggcagtggc cctgaccgag acctgggccg gtgagtgcgg ggtcgggagg 180gaaatggcct ctgtggggag gagcgagggg accgcaggcg ggggcgcagg acctgaggag 240ccgcgccggg aggagggtcg ggcgggtctc agcccctcct cgcccccagg ctcccactcc 300atgaggtatt tctacaccgc catgtcccgg cccggccgcg gggagccccg cttcatcgca 360gtgggctacg tggacgacac ccagttcgtg aggttcgaca gcgacgccgc gagtccgagg 420acggagcccc gggcgccatg gatagagcag gaggggccgg agtattggga cggggagaca 480cggaacatga aggcctccgc gcagacttac cgagagaacc tgcggatcgc gctccgctac 540tacaaccaga gcgaggccgg tgagtgaccc cggcccgggg cgcaggtcac gactccccat 600cccccacgta cggcccgggg tcgccccgag tctccgggtc cgagatccgc ctccctgagg 660ccgcgggacc cgcccagacc ctcgaccggc gagagcccca ggcgcgttta cccggtttca 720ttttcagttg aggccaaaat ccccgcgggt tggtcggggc ggggcggggc tcgggggacg 780gggctgaccg cggggccggg gccagggtct cacatcatcc agaggatgta tggctgcgac 840ctggggcccg acgggcgcct cctccgcggg catgaccagt ccgcctacga cggcaaggat 900tacatcgccc tgaacgagga cctgagctcc tggaccgcgg cggacaccgc ggctcagatc 960acccagcgca agtgggaggc ggcccgtgtg gcggagcagc tgagagccta cctggagggc 1020ctgtgcgtgg agtggctccg cagatacctg gagaacggga aggagacgct gcagcgcgcg 1080ggtaccaggg gcagtgggga gccttcccca tctcctatag gtcgccgggg atggcctccc 1140acgagaagag gaggaaaatg ggatcagcgc tagaatgtcg ccctcccttg aatggagaat 1200ggcatgagtt ttcctgagtt tcctctgagg gccccctctt ctctctagga caattaaggg 1260atgacgtctc tgaggaaatg gaggggaaga cagtccctag aatactgatc aggggtcccc 1320tttgacccct gcagcagcct tgggaaccgt gacttttcct ctcaggcctt gttctctgcc 1380tcacactcag tgtgtttggg gctctgattc cagcacttct gagtcacttt acctccactc 1440agatcaggag cagaagtccc tgttccccgc tcagagactc gaactttcca atgaatagga 1500gattatccca ggtgcctgcg tccaggctgg tgtctgggtt ctgtgcccct tccccacacc 1560aggtgtcctg tccattctca ggctggtcac atgggtggtc ctagggtgtc ccatgagaga 1620tgcaaagcgc ctgaattttc tgactcttcc catcagaccc cccaaagaca cacgtgaccc 1680accaccccgt ctctgaccat gaggccaccc tgaggtgctg ggccctgggc ttctaccctg 1740cggagatcac actgacctgg cagcgggatg gcgaggacca aactcaggac actgagcttg 1800tggagaccag accagcagga gatagaacct tccagaagtg ggcagctgtg gtggtgcctt 1860ctggagaaga gcagagatac acatgccatg tacagcatga ggggctgccg aagcccctca 1920ccctgagatg gggtaaggag ggggatgagg ggtcatatct cttctcaggg aaagcaggag 1980cccttctgga gcccttcagc agggtcaggg cccctcgtct tcccctcctt tcccagagcc 2040atcttcccag tccaccatcc ccatcgtggg cattgttgct ggcctggctg tcctagcagt 2100tgtggtcatc ggagctgtgg tcgctactgt gatgtgtagg aggaagagct caggtaggga 2160aggggtgagg ggtggggtct gggttttctt gtcccactgg gggtttcaag ccccaggtag 2220aagtgttccc tccctcatta ctgggaagca gcatccacac aggggctaac gcagcctggg 2280accctgtgtg ccagcactta ctcttttgtg cagcacatgt gacaatgaag gacggatgta 2340tcaccttgat ggttgtggtg ttggggtcct gatttcagca ttcatgagtc aggggaaggt 2400ccctgctaag gacagacctt aggagggcag ttggtccagg acccacactt gctttcctcg 2460tgtttcctga tcctgccttg ggtctgtagt catacttctg gaaattcctt ttgggtccaa 2520gacgaggagg ttcctctaag atcttaaggc cctgcttcct cccagtcccc tcacaggaca 2580ttttcttccc acaggtggaa aaggagggag ctactctcag gctgcgtgta agtggtgggg 2640gtgggagtgt ggaggagctc acccacccca taattcctcc tgtcccacgt ctcctgcggg 2700ctctgaccag gtcctgtttt tgttctactc cagccagcga cagtgcccag ggctctgatg 2760tgtctctcac agcttgaaaa ggtgagattc ttggggtcta gagtgggtcg ggtggcgggt 2820ctgggggtgg gtggggcaga ggggaaaggc ctgggtaatg gggattcttt gattgggatg 2880tttcgcgtgt gtggtgggct gtttacagtg tcatcgctta ccatgactaa ccagaatttg 2940ttcatgactg ttgttttctg tagcctgaga cagctgtctt gtgagggact gagatgcagg 3000atttcttcac gcctcccctt tgtgacttca agagcctctg gcatctcttt ctgcaaaggc 3060acctgaatgt gtctgcgtcc ctgttagcat aatgtgagga ggtggagaca cagcccaccc 3120ttgtgtccac tgtgacccct gttcccatgc tgacctgtgt ttcctcccca gtcatctttc 3180ctgttccaga gaggtggggc tggatgtctc catctctgtc tcaactttac gtgcactgag 3240ctgcaacttc ttacttccct actgaaaata agaatctgaa tataaatttg ttttctcaaa 3300tatttgctat gagaggttga tggattaatt aaataagtca attcctggaa tttgagagag 3360caaataaaga cctgagaacc ttccagaatc tgcatgttcg ctgtgctgag tctgttgcag 3420gtggggtgtg gagaaggctg tggggggccg agtgtggacg gggcctgtgc ccatttggtg 3480ttgagtccat catgggcttt atgtggttag tcctcagctg 3520 85 1923 DNA Homo sapiens 85gctgagcatc gccagggcgg gcggcagggc gcggcctctc cgccgggtgt acctcctgtc 60gcggcgcgag acctctggtg aaagaaaaga tgttgtcccg gttaagagta gtttccacca 120cttgtacttt ggcatgtcga catttgcaca taaaagaaaa aggcaagcca cttatgctga 180acccaagaac aaacaaggga atggcattta ctttacaaga acgacaaatg cttggtcttc 240aaggacttct acctcccaaa atagagacac aagatattca agccttacga tttcatagaa 300acttgaagaa aatgactagc cctttggaaa aatatatcta cataatggga atacaagaaa 360gaaatgagaa attgttttat agaatactgc aagatgacat tgagagttta atgccaattg 420tatatacacc gacggttggt cttgcctgct cccagtatgg acacatcttt agaagaccta 480agggattatt tatttcgatc tcagacagag gtcatgttag atcaattgtg gataactggc 540cagaaaatca tgttaaggct gttgtagtga ctgatggaga gagaattctg ggtcttggag 600atctgggtgt ctatggaatg ggaattccag taggaaaact ttgtttgtat acagcttgtg 660caggaatacg gcctgataga tgcctgccag tgtgtattga tgtgggaact gataatatcg 720cactcttaaa agacccattt tacatgggct tgtaccagaa acgagatcgc acacaacagt 780atgatgacct gattgatgag tttatgaaag ctattactga cagatatggc cggaacacac 840tcattcagtt cgaagacttt ggaaatcata atgcattcag gttcttgaga aagtaccgag 900aaaaatattg tactttcaat gatgatattc aagggacagc tgcagtagct ctagcaggtc 960ttcttgcagc acaaaaagtt attagtaaac caatctccga acacaaaatc ttattccttg 1020gagcaggaga ggctgctctt ggaattgcaa atcttatagt tatgtctatg gtagaaaatg 1080gcctgtcaga acaagaggca caaaagaaaa tctggatgtt tgacaagtat ggtttattag 1140ttaagggacg gaaagcaaaa atagatagtt atcaggaacc atttactcac tcagccccag 1200agagcatacc tgatactttt gaagatgcag tgaatatact gaagccttca actattattg 1260gagttgcagg tgctggccgt cttttcactc ctgatgtaat cagagccatg gcctctatca 1320atgaaaggcc tgtaatattt gcattaagta atcctacagc acaggcagag tgcacggctg 1380aagaagcata tacacttaca gagggcaggt gtttgtttgc cagtggcagt ccatttgggc 1440cagtgaaact tacagatggg cgagtcttta caccaggtca aggaaacaat gtttatattt 1500ttccaggtgt ggctttagct gttattctct gtaacacccg gcatattagt gacagtgttt 1560tcctagaagc tgcaaaggcc ctgacaagcc aattgacaga tgaagagcta gcccaaggga 1620gactttaccc accgcttgct aatattcagg aagtttctat taacattgct attaaagtta 1680cagaatacct atatgctaat aaaatggctt tccgataccc agaacctgaa gacaaggcca 1740aatatgttaa agaaagaaca tggcggagtg aatatgattc cctgctgcca gatgtgtatg 1800aatggccaga atctgcatca agccctcctg tgataacaga atagaagcac tcccctgata 1860aatactttct gtgctccagg gaaccccttt tttcagacaa gaagagataa tgtcttcagt 1920ttt 1923 86 286 DNA Homo sapiens misc_feature (1)...(286) n = A,T,C or G 86ctcttttctg aaaaccagtt gcaaatagtt ttactcaact tttcacactc aaaaacactt 60taaattttaa aagctaaaaa ctattnacaa attatccatt ttaattttaa aaatgtttgt 120tgttggtttc attgttccat gttaaaaaaa aaaaatcggc ctcgtccaac aaccatacct 180cagctgctac caccattaac ttctggctgc cgtgaagagt acttagaatt ggccccttac 240aacttttcag aggtccaaca tatattctgt tccacggccc atgata 286 87 1029 DNA Homo sapiens 87gaattcggca cgaggaaata aaccaagaaa ctcctgggtc tgaaaaatat tcacctgaaa 60cgtatcaaga aatacctggg cttgaagaat attcacctga aatataccaa gaaacatccc 120agcttgaaga atattcacct gaaatatacc aagaaacacc ggggcctgaa gacctctcta 180ctgagacata taaaaataag gatgtgccta aagaatgctt tccagaacca caccaagaaa 240caggtgggcc ccaaggccag gatcctaaag cacaccagga agatgctaaa gatgcttata 300cttttcctca agaaatgaaa gaaaaaccca aagaagagcc aggaatacca gcaattctga 360atgagagtca tccagaaaat gatgtctata gttatgtttt gttttaacaa tgctcaacca 420taaagttgtg gtccaatgga acatacagct taatagttta tgcgtgattt tctcaaaata 480ttgtaaaact tttgacaatg ctcattaata ttattttttc tatttgtaga ccatatctga 540aagaaataac attttttaag gctctaccac atagacaata tcatgctaga atgtgtgtgt 600gtgtgtgtgt gtgtgtgtgt gtatgtatgt ataggtcggg gagaggatag tggtgggaac 660agacaaataa ggaagcgggg aggactggat aattggtttt cccccctaag aacatttatt 720tacgtcttaa gagcagataa gtgactaaga ctgaacacat acattttgtg gagtatatag 780ttttcttgta aatgctgttc aattattaat gtaacagtag catcaaaatt ttattcaggc 840tttagttgac tcttttggtc agttttaaca attctcctta aaagatattt tggagtgatg 900aatgtagttt acttttgtat ttgaattttg attttctatt tttatttttt aaatattgta 960tttgtgcaca atgtacatta aatcattatt acatgcttaa aaaaaaaaaa aaaaaaaaga 1020tgcggccgc 1029 88 268 DNA Homo sapiens 88ttaaattcaa gtggaaaagc gtatcgaaat cttactgcta aaagttctag gtcctcaaat 60gtgtattcat taatcataag atgatatcat ttgggaatca ttttattcct ttatgttttc 120aataaatacc tgtggttggt gccaaacact actcttgaca ataggcattc aagcagttaa 180taatgtcagt accattttta gatatcttag ttttggattt gagcagaaac ttatgaactt 240ttttaaacag tcattaatcc atattgca 268 89 930 DNA Homo sapiens 89gaattcggca cgagctgtct tcggccttct cttcccaaaa taatggatga cttttttttt 60tccactatta gaggctgtta gcactcagac ttcatcctga acctggatta gtgatcggtt 120ttgttttaag atcctaagag cacaaacaat gagacagaaa caggctccat tcgctaatgc 180actgctcatt gaggaatgtc agtgatgaca tacatgtgga aaatttgggg ctaccagacc 240tctccccagt ctcatctcag tctcaggccc agaatgaggt gaaaattgga gagagggccc 300tggagcagag aaagggggat tcctgggaca tgtagggcca tgtcactgag gcaacttcca 360gcaatgattt acaggaagcg tttagctcat gcatatattg gggccaatct gaaaaggaat 420caagggttat gaaactctca actgtgacat tttatagggt atggcgcaac cagagttagc 480taagtacaga tatcattagc tatatgttca tttgattgct attacatatt ctctctctct 540gacacacaca tacacacaca cacacacacg cacacacaca cgactgaatt atattcagca 600gtattttatg ctctttggaa actgttactt attcagatac agggtgtttt gtttttgctt 660tttgctgatt ctctactaat tttattattc ccaatactct ctttcatttt gaattatgga 720gtttattgca gtattgtatt ttttgagatg taaaaactat tataattaga actaaatttt 780tcaaaaatgg aaacatgcag gttaaatgat aaaaatagtg tatttgtgaa atttgggttc 840cgttttgttt tgtcatcata gcaaatagaa aaaaaatgag ttgattacag aaaaaaaaaa 900aaaaaaaaag atctttaatt aagcggccgc 930 90 410 DNA Homo sapiens misc_feature (1)...(410) n = A,T,C or G 90cctttttttt ttttttttac taagaggtct ttgctttaag ntcactgcga tgataccagn 60ganaattaac tttnagtctt ttaagtanna ctgcaccctc gcgcaggcca ccagccanaa 120tnctgataag tcgaagtatg gcagntgtgc tgatatanga tgaagtacaa ctgatcagaa 180atgaaaagcg tgtctttttc cancatgcat naggccgaan tccttttgct ctcgntccgc 240ccacatctnc ngctacacac atacacacac acacacacac acacacacac acatacacac 300actcctagcg ctcagtctct ctctctctcc tcttctctca tgataaatca agcaagtggc 360cctaggcagc ccttcaggag gagaagcctt taagtgcaga acaaaatcag 410 91 1568 DNA Homo sapiens 91aagcttggca cgagggtaga tttctaggaa tgaagtgggg cagatcttat ctttgtggat 60tacaggcact gtactaaaaa caggtttcct atttaatata aaaagaaagt gaatcttctt 120ttggatagaa tcatccattc ccatcgccgc accccctacc ccccaaacac acacacacac 180acacacacac acacacacac acacacacgc cctactcttc atttgctagg ggaaggtcac 240agcacaacta aatccaggac aggacattgt gaccatgacc cagccacagt caataccaga 300aagatgattc agagtctgaa gtggtgcccc aggtgccaac aggataacct ctaccccccg 360actttgtctc tggggtcctg ttccttcctg caaagcccaa tccaagactg gcatggctca 420gaggttgtga gaaaggcatg gactggaaca atcatgtcca gaggggtctg gagctttgtt 480tcctgttcac cagcaaaaaa tgtctctccc atttttctga aagtggctga tgtaagaaca 540ggcagaagga aaaccctttt tgtcaataac tctgtcctta aggaatggtc ctctgggagg 600gctgtgctgc tagtgggtac ctcagtcaca cacccccaac cccaggcagc ctctagagcc 660ttcttgcttt cattttcctt gaatgtacat aggaacaagg gggaaagtct cttactgaag 720tgcctgaaac ccaaagctag agcttctaga gacgccgttc ttcctgtctc agcttggcca 780gcctttcaac aatgttctct agtttcaagc tccagcttct cagaaagaat taaagaactt 840gctgttccaa attaagtaga aagtgagact caataataac tgaactacag caaaaggcag 900agaattacag ggagaaaaaa cttgtactta ccagcccaat tctactctcc tcaaactgac 960acacacacac acacacacac acacacacac acacactctc ttttagggga ctaagagaga 1020gaagcatgtt attacatttt actcatccaa acagtaatgc aaaaataaaa cggtagaata 1080tgaaaagctc aggatctctc ccaaggctac ctactgcagg agggccaaca ggtgagatgg 1140gaagaatgga aacagggacc gattttgtag ctcatacaat taggacacct taggaatagc 1200attgtagtaa tggtgatgaa tatgctctgc caaattcatc cagtctgcac catcttatag 1260ctgcccagca cactcgactg ttcatgtggt ctctttgtag tgtgagtttg gagtgtccta 1320ttagcctgtt ctggttagga atgagttaac ggctctttcc ctcaacctta gtctagtccc 1380agggctgagg attcagctgg atccacatgg tcttgagggt tggcatgagg agggggaagc 1440ttttttgaat cgctttttga tcacataatc tgccatttta agagtaagat ttgctttatg 1500gaaatcaatt cattaataaa aaatgatatt caagttgcaa aaaaaaaaaa aaaaaaattc 1560ctgcggcc 1568 92 747 DNA Homo sapiens 92agaattcggc acgagggaga cccagctggc ctggggtctg ctttccgaca ttttgcctct 60ctcactggtc atgtatttat tccatattta tatggtctac ttcctgtggc tgggagcagc 120agctcctgaa ggttccgtgg gggtgcgggg ggttggacag gacactcctt cttggaaggc 180accaattttc ccagccccac tcccattaca cacacacaca cacacacaca cacacacaca 240cacacacaca cacacacaca cactgattca ggccttgaga gtcaagccca agagctccct 300tggccctgtt ccccactccc tccactggcc tctgctgttc ctgtctttgc tcacaccctc 360acagctgctc tctggcagag gttggcatag cctaggagca gctgcaattg cacctgaggg 420acaggcccta gagtttggtg gcccaagtcc tgaacccctc ttagaccagg tgaggtgcag 480aggtggttgc tgcttccagt ttcccttcag acttagctgt gtgaacccca ctcctatcct 540ttggccttag ttttcccatc tgtaaaactc agaaacgcag ttggaaagtc cttattcatt 600tagtaagcga atatattata atatgtatag agcgcctttt gtgtaagtca ctggtcagaa 660tcctcactga gctcccagtc cagagagaag ccagacaatt aaaacagtaa tgacaatgaa 720aaaaaaaaaa aaaaaaagtg cggccgc 747 93 1820 DNA Homo sapiens 93gaattcggcc gagttttttt gttagaccct tgaagctgtt tttgagaata cagattccaa 60tacaaccaca aaaaccttac cacatctaag aaaattaata ctgattctat cttatgtaat 120atctgttctt tatttaagtt tcccgaaata tccccaaaat atcttttata gctttcattt 180ttttccaaac caggcaaggt ttatacattc attgcatgcg gttatgtctc tttcatctct 240ttcaatctag aatagcccac cccatcatct tttcttctgt tggacagtta tactaatatg 300cagagatgat gtcatatttt tcactacaga aaaagcactc ataaatatgt ataaatgtat 360atcgatcata atgcttgaga aggaatgggc attggaccca tacctctgca ctctggcttg 420aaggaagatg aaaagtttct agatacaaca gaggaaatga taatatagag aagtccagga 480ggtacaaagt ctgtgtgaca aagatagaaa gtagaggaat gtgatacaaa gggagaaata 540aaacctttga atcttggagc tatataataa atgttaagat tcttcatact gaggttgtga 600agcaggacaa tagtgaagag gaatactgaa gaaattatag gagttttaaa aatgattaca 660agatatatcc tatatagaga gaatattaca atttctggtg aaaactatca aatataaggg 720gatattctcc agaacgaaaa ggtgaaagaa aacacctcat tggcactatg tagaagaaat 780gggttgtaat tatccaccac tgcacctgcc agccacgaat ggctgtttaa acttcagtta 840aactagttaa aattacataa aataaaaaat ctagtccctc agtcacactg accacatttc 900aagtgctcaa tagctataca tagctagtgg ctccatatta gagtgttttc atcatcgaaa 960aaagtttaac tggccatcac tgcaatagat tcaatataaa ggtatgctgg cttttagggt 1020acacattcaa ggtttggtag ggagcctatt aaaactgatc aaaatccttg attgttattt 1080agtctggatg aatcacatag gggataatga cagtgaggaa gagaacacgg aagcatattt 1140agagtcctca caaaaaatct ggatgtgctg ggaataatag gttgtgtgtg tgtgtgtgtg 1200tgtgtgtgtg tgtgtgtgtg tgtgactcct tattgttgat tgacacagtg gaacaatgaa 1260ggaagatagt agaagacaag taatctagtt ttacctgtgc tcttctctct tgcaaggtag 1320aaggctaagc ctttgatcca ggctggaggc cctgaaactg ggattgatag gatgggctta 1380ttactgtggc cctgaactga agcccagttg agggcggcct gggaagcaag gcatgaacac 1440agccttgata aacaaaatga gtaaaggatg cacagttaag agccaaaaag agaatagcct 1500gaacgtgtag aaggaaacta aagctacaag ggagttaaaa gctggttgaa gtgagtgttt 1560tgggggtttt ctgtgaatta ataattttga agaggaaaca gccctggtgc gtggggcaca 1620ttttcgtaga gaacacaaag aaaagaaaac ctctttggta catattttct ttcagtattt 1680ttgggcaagg agaatgatgt actttttact gacaagagta taactaaagt tgccattaac 1740agaaataaag cccagttatc ataaaggaac tgaagtccaa gattaaagaa aaaaaaaaaa 1800agatctttaa ttaagcggcc 1820 94 1497 DNA Homo sapiens misc_feature (1)...(1497) n = A,T,C or G 94gaattcggca cgagctgtta tatgaacaca cacacacaca cacacacaca cacacacaca 60cacacgcaca cacataccac atttcaataa gtcttcattg ttctgggtcc ttacctttcc 120tgtcctcctg ttatatgaac acacacacac acacacacac acacacacgc acaccacatt 180tcaatgtctg catggttctg ggggtaacaa aggcaagaag ttaaagtaag accacatttg 240ragtattact tactctgtmg mayywwramm kmrtwkwkaa mmccmmwtww ksmaamywmy 300tttttttttc mgsmwraarg ggrarsykrm mwkrwymaaa wycmwkgktt tymaaawkgr 360amykgraaar rgsmwtyccr smmmmwytww wammmmawtt wawtttymar ktycmrggsy 420tkrmmrgscc ykggggsmwt yywarsmarg rwtgsmwwaa wtkggymawy ytgkkgraar 480rktkggkwmy tttkgytyma wttttwawtw mccmawyytt yyyykgattg taattacctc 540caytactttc atgatccccc tacaaatatt tttttaaatg atatatttat tcactgaatc 600aaatgtcatt aatgagttat cttcttgtgg aggatgactg ttctctttgt taatgttcac 660aatcaagatc ttgggctgag aagaggccct tcacccaagg agtttgaagt atcacagcgt 720gtggggaagg tgggaaccag ggatacccat tcatttccma ccgagacaca ggaggaagtg 780gagtcacaga attttgagcc cgctctcttt gactgcccag ccagagacac ttgattyykg 840taacctcttc acttggatcc tgcctyttna agcwttaaaa ccattctcct taaacctctg 900agtgttttgt gggttctggg tgttttgtac attttagcca agctaaccac ttgtctgcaa 960gtacttgact ttcctatgaa ttctttgaag attattgagt cagaaaggaa aaatatagcc 1020ccaaattccc aggcttttaa tgcattacat taactgccta ttgaaatgag aagttcttca 1080caaacttgta tacccactaa caagattgca cataaacatg caktaaagta tatactraga 1140wrccmtctgt ccaacggctc atgcatatgn aastccswwc atgggagytt gccaattgca 1200ttcatcaagt cgttttgcgg agtcagatcc ctgatggaag agctcacagg ctctgccttc 1260caagtcctgg gttcctaact ggtgacctta gcctggggtc tgtggggaga ccaaccctgg 1320cttccaagaa aaccacattc catggactat cagaaataga cacagatttg ggtgacaaag 1380ctggctctgt atttgcattt tatttttgtg twmwatgtca gtttgggaat gattaatatt 1440aaacatttat ttgagaaaca aaaaaaaaaa aaaaaaaaga tctttaatta agcggcc 1497 95 583 DNA Homo sapiens misc_feature (1)...(583) n = A,T,C or G 95cccacgaggg tgcaatcctc gtaggctgat cggtcccatt tcaacactgt gagactgagg 60gtacattaga ggaaatggtg tatatgatcc ctatgaaacg attctttggc ttttgtttaa 120aaacaaaacg ggtttgttct cataatctat agaactatga agattactgg atcatatttt 180tttctcttaa ccaggagtgc ctcagagatt ctgctatgac tttggacttc tctgagtctg 240tgcaatcatt ttctggagaa gcatggggaa aggtggtaga ctgctgcact ttttcattaa 300aatgagggta gctctttctc caccccccca tctcctttat cccgaagaca taaatgttca 360attacggagg catttaaatc aagttgtgac cacctccatt ggagggcagg actcttgatt 420gtgtaattga taatgcactt tctcaatggg ctgtatagtc attattaacg tgtcttccct 480cttccccaca aggacatata aggncatttc tgccttcaag tttggccaac taacaaatca 540gaatctgagg ggcatgttct atttcccagg aatgattgac act 583 96 943 DNA Homo sapiens 96gaattcggca cgaggggatt ttttaaagct tttctgttca ccctcctgcc aggaaaatcc 60cagaaagctt aatgataccc caaaatgatt acacccaggg aggaaaaaaa ggagcgcttt 120ctagggtcag aatcgtggag agaatactca gaaatgaacc tctttaaagc cttgcaggaa 180tgagtcactc ttacttaatg aaatgttaaa gccaattaaa aagcatgctg tgatgcccag 240cttccctttc cacagggtgc atgcgtctcc tgctggtgaa tcacatgcgg caagaggcaa 300ctggctccac agcctgggat gctgccgtac caagaggaaa gaagcagcaa aatgccttta 360cgttgttcta aacccccgac gcataaagtg tagaggaggg atggccaagg gtgggtggta 420gaaagtgtgt tcaggctgac actggcaatg agtacagata atttcacttt cctcttctag 480gggcaaaggc tgatggcctc tacctttgta tccaggagaa actgcagagc agccctgtga 540ctttacaaaa tatgctacct caaagtgcta ccgataaacc tttctaattg taagtgccct 600tactaagggc acatgtctta atcaaagtta gttttttgtt ttctggtttg tttttttttt 660ttgtatattg atgaatgaga tcttacctat taaatatatt attggattat ggttcctgaa 720ggtcattaga gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt tttatgactt aaatatcttt 780acgtgtgttt tttagagctt ggttctttaa agatttggag aagatatgta aattaccaag 840gcacttggtt tttctgtttt atatactaat aatcagggcc taagttaaat aaaaatatgt 900gtgcatgtat tttaaaaaaa aaaaaaaaaa aaattgcggc cgc 943 97 566 DNA Homo sapiens misc_feature (1)...(566) n = A,T,C or G 97agggantaag cttgcggccg cttaattaaa naanatttag cgtaaaatta cacttaaaca 60ttatcagctg ctgctgggaa aaaatggaca aattgcccag gcagccacat tagaagaaga 120aagtcattng aatacagnta tatacttatt tttattgaga cacatcttgc tgngtcaccc 180agggttttgc tctgttgcca cagcttactg cagccgtgac ccaggctcaa gtgatccctc 240ccacctcagg cccctctccc cgaccagtag ccgagactac aggcaggcac agactggcac 300caccacactc ggctaatttt ttttttttga ggcagggtct cactatgttg tccaggctgg 360tcttgaactc ctgagctcaa gtgatcctct naccttggct tccaaagtgc tgggattaca 420gacaagtcat ggcanctggc tgagtacagt tattcancat aagcataaca aatacagaat 480ggcagcccag ttcctttgnt aatgaaatng taaggggtgt actagggcaa gctggccctg 540attatgtcac atgagtttgg tttaga 566 98 454 DNA Homo sapiens 98gttcatcacc atggactgga cctggaggtt cctctttgtg gtggcagcag ctacaggtgt 60ccagtcccag gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg ggtcctcggt 120gaaggtctcc tgcaaggctt ctggaggcac cttcagcagc tatgctatca gctgggtgcg 180acaggcccct ggacaagggc ttgagtggat gggagggatc atccctatct ttggtacagc 240aaactacgca cagaagttcc agggcagagt cacgattacc gcggacgaat ccacgagcac 300agcctacatg gagctgagca gcctgagatc tgaggacacg gccgtgtatt actgtgcgag 360ggggccaaga ctattagccg acgtattact atggttcggg gagttatccg agtttgacta 420ctggggccag ggaaccctgg tcaccgtctc ctca 454 99 122 DNA Homo sapiens misc_feature (1)...(122) n = A,T,C or G 99agggcgaatt gggccctcta tatggatcgc actttttttt ttnttttttt ccattcacta 60attgtaatta atttagcata agcaaagaaa tgaccttagg aacataccca ggttttaaga 120ta 122 100 967 DNA Homo sapiens 100gaattcggca cgaggctgga agtggcagaa ctgagatttg cgttccaacg tccattccca 60tccttccata tcaccctgat tttctcgggt tcagagtcct ggttcatttc ctggctgttc 120cgcagacatg tcacaaactc cagaaccttc atttctccat ctgcaaatgg caattgtaat 180tcttgctctg tcaacctcac agatttctct cgaaggcata cacacacaca cacacacaca 240cacacacaca cacacacaca ctagaaaact gtaaagagat gtaaacctta ccgaataatt 300acagggtatt ttgattggta tttttactat gattattttt gctaatcaaa gaaaccagac 360aggtagtgtc agggaattgt ctaaagcaat gagacattct tgaaaagtct gtatcagatc 420tccacttctt gccagagaaa atcgccttaa ggtgtccata ggtgtcctgg cttccagtga 480ggcaacctag caattaggaa agaaatgcat ggtgagtgct tcgtatgggc actcatcaaa 540tgagcctttc agagctcaat agaaaaccct atcccagtga atcttctgtt gtgctgaaga 600ttgcagctga agattgttgt cccacacagc acagtgatgt tagaattggt tgagctccta 660atgtggcaag accccacaca tttctagatc cacccagaat gaggtaaacc cttccaaaga 720aaaagagaaa tatcgaatgc tgtattttga gtcttcttac tctgtgggat tgatagagca 780agaattacaa gaattctttt gagtctaaga caccactgat tttaaattac acttaaagtc 840ataccagtga tttttggaga ggaggaaaga aaataccaca tttaacaagt atatcaattg 900ttagaagtag cctaatttca aaaatgttaa aaatgtaaaa aaaaaaaaaa aaaattcctg 960cggccgc 967 101 588 DNA Homo sapiens misc_feature (1)...(588) n = A,T,C or G 101tttttttcag agtaaacngc atgtttattt tgaacattca agtttacaaa aacaaaaagg 60tntttnaacc atgacacann tcacacacat acacacacac acacacgcac acacacgcac 120acatgttgca gctcatgtca atttatgtac aaaacaggga gaggagaaag gggcaaggct 180ggggaggggt tgtcagtagg gtgcactaat gtcacagtgt cagacaactt gacatgctca 240ctcacactca gcctgggccc atgtgagccc cttccccacc caggggtcgg gggtcagggt 300gggaggtggg ggtctggggt ggcaggcagt ggaataaagg ggtgaagaga gtagtccctt 360ctctgggagg gagccccttt ccaagtttac tcaggccaag ggtgctggga cacacaaagg 420aggggggact caatgctggg gagaggctgg ctgcgtccta naagagggct gaatgcagtc 480agaaggctgg gcttaagttt nccgtgtcag ctgggtggcc ttgaggtcgc tcccctcccg 540gcttnacttc ctcatctgta aaatganggc tttggccttt tttaaaac 588 102 553 DNA Homo sapiens misc_feature (1)...(553) n = A,T,C or G 102ntcctttttt ttttttttaa tagtatcatt catttgtaca gagaaatcat ttggatggat 60ctatttacag tcttttctga ttatcatttc cactggccaa atatttcaca gaatagtcaa 120cactgacttg aattgatcac cattataatc gggcttttac tcctcctccc ccctttcaaa 180gatgatgatc ccattttaac agaaacattt tgtaataaaa gattcaccag tctttttcca 240tcttatgact aaatccacca aaatttatct aatatggtca aatttttaac acatttcatt 300gtttcttttc aaactcatta tttgcaggta ttgcaaacca aggcaaataa gtccacgtcc 360cctcgagcct tctacaactt actacacgcc ctcaagttga gcttctccta tctcctttca 420cacttgtgaa atgtctggca caaccagaca ttttacttga agacaaaact actctctttt 480cctctctttt tcttttaact cactaccaat caccttccct cttgcatttc agacaacact 540aaaactttca aca 553 103 1650 DNA Homo sapiens 103aagcttggca cgaggtggat ccactagcta cactggctga gaatgctctc accccaggat 60ttcattttta ttttaccaca tcattgttgg tatcttaaga tcaatgtact ggagcagcgg 120ggtctcacaa agaggatacc tggtgacacg cccaggcttt cagaatgcac tatagggctt 180tagtgacttg tccaggttca gctgaaatgt gccatctggg acctactaat gcttgttgaa 240ctttactgga tctcagaagc tgggtctcag aagctcagat gttcctcaga gctacgatat 300caacaacctg tgatgacaga gagaaggttg ctccatgatg gatttggaaa cttactggct 360agctaaacct gactgaatgg gaaggaatgt ggatagcttt ggaactctag tttcactaga 420tgagctggaa tttgtatttt gacaaattgc acgttatgat tattaagtaa tgcaactgat 480ttttttttcc cttaaaacaa acaatctaga atctgtgtaa tcaaaataat ttctctaaaa 540ggctgcaagt atatgcttaa agtgttgggg cattcagagc atttggaaca ttacattctt 600ttgaatgtca attggtagat gaaaatacca gcttttaagt catacatttg attttttgaa 660acaatatgca tttagagttt gtaagtcaag tgaataactg ataaggtaaa aaaaaggggg 720agttcattgt tgagtatgaa tttaaagtaa ccagactgcc ttttgtccag tggctgtcag 780taatttactt cagcaggcat tttttttttt ttgaggctgt tctatgatat catgaccctt 840cttgtaggga tgagcttcca gtggtgaggc agtctgagaa tgtgtgaagc agtataatga 900agccagacca agatggaagc ttggcctggg atttgagcat caggaaaact gttgaagggt 960tatgtataca tcacacacac acacacacac acacacacac acacacacac actctcttcc 1020atactcctat aacaacgtat agtatttact atacctggtg acaggtattt actatacatt 1080gttgaagatc tataacatgg aatgcctagt gctaagtgca gtgtccttag tgaaattgta 1140ttggtttgga attatttatg agtttgggat tatttgtcac tacccttaaa tgatcttgac 1200actcacctat ttgaaaagat attgaggatt tgccatttga tattgaccag ggtgtattgt 1260gcacaaatat tgtgaatata catctgtctg tccttaaatc actgtaagtt ttaactggaa 1320tagatttgct ccacattact cggtagggct gatatttcat gcctcatgga tgagaaaaga 1380ataggcaaaa attatatctc gggctgcctc acacatcttt taacaggata agggaaaaat 1440aaatataaga cctatgagtt atggcatcag gcttgaactt taatttatga attaaaccaa 1500caatattatt gattattgca attatctatc ttaatttcat ttgttctcct tttaaaaatt 1560aattatgttt attttaccta ttgtgaataa agtcactcct cccatgtgct taaaaaaaaa 1620aaaaaaaaaa aaaaaaattc ctgcggccgc 1650 104 590 DNA Homo sapiens 104ggaatccttt tttttttttt ggaattataa aacaaggctg agtctgaagt taaatgtgtg 60attatgctag aaatattttg ctagactctt tgcatctctc cctgattgcc tactttctct 120ccattctgta cttgcacagg agaaatgaaa acacaattct tgtggcacgt ttggtggaaa 180aatttctttg aatgtatttg ctaaaccaag agatcttaca aaacatggta aaatactttg 240gctatatttc catcagccca ctgaagtgag ggcttgagaa gcttagtgca ccttgttttg 300tgagggagga ggcaatgccc ttttatgaca atattcttga attcaatgtt tgtttattcc 360cttacttcta aatatgcatg tatctacgtg tgtatatatc tgtatgtaca tgtatatacc 420acacacacac acacacacac atgcatgcac gtgcacacac acacatacac acacacacac 480acacagtgat tccttgcaag agttccttaa ctgatttcaa atttttattt acttatgtct 540ttattttgta gaaggtggtg tgggtagatg acagggtgtg agaggcgaaa 590 105 541 DNA Homo sapiens misc_feature (1)...(541) n = A,T,C or G 105tccagggaat aagcttgcgg ccgcttaatt aaacgatctt tttttttttt ttttttttcc 60tctcatttag tctcagagcc taaaaagaaa tgcctccagt ctctgttagc cccgatgttt 120ggaatgaaat taacaagatt ctaccttaaa agagaaaact tatgtgggct tttcaaattg 180tgaaaatttg ttccctctta taaaatataa tctttcccct gctgctggtt tataaatatg 240ggcatatagc ccagagccat tataaagaaa aaacaaccaa ccacaataaa ctaaggagcc 300tcatctgatg gctaaggttc tcaggaaaaa atgagaagag caccttgatc aggaaaggaa 360aaaaggatag aggataaaaa cagtaacctt taacttctat gccctnactc agccagtaac 420ttacggcagg tgttgctggc aaggccttag ctgnatttct tcattaagtt gaacatcctg 480tctgccactc ctaccaaccc agctgctnat aagctgccct gagcacccan gaaaagaagg 540g 541 106 776 DNA Homo sapiens 106gaattcggca cgagcactac tgaatcttga aactataaat atattattga tatggaccac 60aattgctgtt ttggaaatca gtgttcacac atcatgttca agcagttaca aagattttat 120gtagataatc agtcagctga tatattttca tgagtcatta attttaagat actctatgag 180tcacatctgt gattttcagc aagctatatt tatgataaat gatggacaga ttttgagtag 240tacagattga aaatttttga ttaactcaaa gtgaagtatg ctgagagatc aaggacacag 300acatactctt tctctagcat gtgcgcgcgc gcgcacacac acacacacac acacacacac 360cactcattgt atttgaggtg aagcagttgt taatgtgtgc tttgtacctc acctaggaaa 420atcctaaact ttctttttaa ctattttaca aaattggggc acatacttaa gacatttcat 480taggtggtgg tgataatcat tatataaaaa tctaaagcct gaagtgaggt tttaggcttt 540gcatagatta taatatgggg aaatgtttgc aatgtgataa catatacatg atgtccacta 600ctcacctgta attagtctga ggtagtgggt tgatgttaag ttctctattc aggcttcaag 660atactgtttg ggggctggcg gggagggaag gtgcagccca cttttcaaaa gaggaagaat 720tggttgtaat gttggaaaaa aaaaaaaaaa aaaaagatct ttaattaagc ggccgc 776 107 468 DNA Homo sapiens misc_feature (1)...(468) n = A,T,C or G 107attaaccctc actaaaggga ataagcttgc ggccgcttaa ttaaagatct tttttttttt 60ttttttttga gggttttctg ttatttcttt attggggtgg gggtggggtg catcattcag 120atctttgtgc tggtgcctac gtgcatacaa gtacacacac acacacacac acaggcatgt 180gttcacgtat gtatacatat acacacaagg ccagagctct agtgtgctgg aggaggggca 240agctcttttt ccaagagggt attagaaaga ggttgattcc agaggatgag tggtctctga 300ggctatagcc ccccactggg tgggcagcca gctctgtgag aatgccaggg tgcagctgac 360agcgctggag gcctggggac tggactctga gaggagcttg ggcagacaca gcagcctccg 420gccccaanac tgccctgggt tggcaggccc aaccctggtc ctgacagg 468 108 515 DNA Homo sapiens misc_feature (1)...(515) n = A,T,C or G 108tccttttttt ttttttttaa attgaattta tactttatta aaatcaaaca atacaagcct 60taaaatttga ttttntaaca ttataaaact atgcatcctt tatgaagttt cagttgatat 120ctgattaaaa aacactttgt ttcataagtg ttcagtgatt tatgaaactt ttaaaacaaa 180ttaagatggg atttattaca tcttatagcc attattggac ccattctaca ttttgaaaga 240ctaagagaat agggttagct atgggaaatg ctggctcact ggaagaatcc tgcattttcc 300aacttcccca ctcctagaag ttttgctaac aggaattgca actaggaatg cctcacctga 360aaaactaatt tcatacaact ttcattaagt agtttgacaa tctgtgaccc acaaatactt 420ccatagaatg gtagaattat ttataatcag aaatggatgg tgggggtata aagggaatca 480agagaggana gaaganggct aatggtggtt cttca 515 109 1179 DNA Homo sapiens misc_feature (1)...(1179) n = A,T,C or G 109aagcttggca cgaggaattt cttaaagcaa acaacaaaaa tgtacatttc tgtttttcct 60tttaataaac aggtgtactc tttatcatgg ttggtatgat ggaccattct ttggggcgga 120ggattgatta tgttactctc tttaaaatct gttcccatat tgaacaggca gattggaaaa 180gctatggttc gatttctcag aagaaatgtt taggtcttag tcaatagttt taactatgcc 240atttgtttaa atgagtgcat ttgcttcgag ggtagtgtct tactaaaagt taggaacaga 300gacctagtgg gtgtgtccaa ggccgtgtca ctttcccctt cagcacaccc cagcttctga 360cctcagagcc caggagctgc gtggacagtg tggggtgcca ggaggagggg cggtggctgg 420tcctcaggca cgctgcactc ccagccagac atggtctttc cgtttcttaa gtagcaagtg 480taggtttcag ctggcagttc cacctgcatg ttctctgctt cgctgccttg gaaggggcca 540cattccccat tcctcttctc cttacagcgc ctgcctcctt tttcaagcag gcggaaagct 600gctgtttctc acgtttcagg gagaggggtg agcggaggga gacctgtgtc cgtgccgtcc 660ggctccctgg gtgggaacag gcaagggatc agatgcccct gacaccacgc ctctggccac 720accagatgcc tctgcagtcc tcgacagcct cttcagtgtc cctcctgcgg tgatgtcctt 780actgtcccca gccagggccg gggaccggtg tttcactgag gacctgcatt agaaacattt 840tttaaattgt tgtacaggaa gagatgtgtc taaaacagca tcttaaagct gagtgtattt 900ctttgcacaa ggggtcatgc tgatgaattc ttctttcatt ctgatctttg ttcagccaac 960aggagcgtcc ttttctaatg tcttccattc ctacccccca cccaaaaaca aaagaaatat 1020ttgtagcttg ctatctgtat ttgaattttt agcaatttta tatttagata ctttgaaaaa 1080tgtaaatgac taatttggtc attaaatctt gtgacatatt cgatattaaa atgatattaa 1140aataaaagtc atataaatca aaaaaaaaaa aaaaaannc 1179 110 510 DNA Homo sapiens misc_feature (1)...(510) n = A,T,C or G 110ccngggaata agcttgcggc cgcttaatta aagatctttt tttttttttt tttttgagga 60gataaaccaa ttttatgtct atcatgttat acaaaaatct agaaataata gatttgtaca 120gaaaaaaatg ataataaatg agaacacaaa acatataatt taaatttggt attttttccc 180ccatgatatt aggatgataa tcatttcaaa gcacatgtct agcttcagag taggatttgt 240tcactggcca aagcctgcca tgaaactatg gctttcagca tctgtctgct ctactggctc 300ttgacaaaac tcttgaggtc ttcaagaaaa gtaatgtact cctggtgctc cagggctgtg 360ctgagctcca ccagctcatc tgcaaaagtg ttgtccaccc ctnggtcggc aaggaaatcc 420attaggtggt catataaggc ccagtccaag gaatctgtgt tgagtgtata attagtattc 480ttccattcag actcgccagt ggactaaaag 510 111 1634 DNA Homo sapiens 111aagcttggca cgagggcctt tgtaacaata aatagtgata gtgttgtttt cattcatctc 60atccatttat aagtctaggt attagatcta agagaagata ccctctgcat ccaactgcta 120aagcagggaa ctgggcaagg agctacatcc ttcatcaact atccagtcaa atgcaaggga 180aagggctgaa gcagcaagca aatgaactca gaagaggtga aatcaatgaa tttcatgttc 240tttccattac catttgctag gtcagcctag ctatcctcat ggtcaaagat taataaacag 300aaataaaaac aaattcacca ttgctaggca ctacaggaag ctaaaaagga aatacttgaa 360gattcagaaa aaaataaaag gaacacttac agtgatttac taccaaaata aaaacatttg 420tgtttctcga taagtattgt attcccggct cctaaaatct ttgtatgaca gatggtcagc 480attcaataaa tatacattga attagtgaat aatcttttag aaaatgattc catatcctca 540gtgggtggca agaagtcttt gaatccataa agcatgaatg taaggctata gaaagaataa 600actgagacca aaaaatatat agagagagaa agagagaaaa gaaaagaaag caagaaggca 660agcaagaaag aaaaaaacag aaacaaaaga gaaagaaatg aaaacaatgt acaaagtaag 720aaaatatgaa aaatgaaagt gcaattgagg gattaataga tgcgtgtaaa taaaattttc 780cacatatata agaatttttc catagataga tagatagata gatagataga cagacagata 840gatagataga tagatagatc ctactctagg tctataattt gtcttttgat gtcatgttat 900tttttaataa acaggaatat ttattatata aaaaaatctc tctctccccc catggcccct 960tcttcctggt ttctagtttt tatgtctgac ttagaaaaac ccttatcaaa ctaaaattat 1020ctttctgatt ttccctaatt ttatatcata tttttaattt taatcttttt aacctaactg 1080aaatttttta ttatgtctga tgagcaattt gtgtttaata aatgatatta aagaaagaaa 1140ctttggaaga agtcactgat ggtggcttgt aattacagac taagtaattt ggatcatgat 1200tccttccaaa gacatcttaa aagctgaaaa attataaaaa taatctcttt gtaggctttg 1260gagaattaag aagatggtga gaaaatagtg ggcaatgatc cataagaaga taaacatctc 1320aggccgggag cggtggctca cacctgtaat gtcagcactt tgggaggccg aggtgggcag 1380atgcttgagc tcagaagttc aagatcaccc tggctaacat ggtgaaaccc tgtctctact 1440aaaaatacaa aaattagcca ggtatggtgg caggtgcctg taattccatc tacttgagag 1500gcttaggtag gagaagtgct tgaactgggg aggcagaggt tgtagtgagc caagattgtg 1560ccattgcact ccagcctggg caacagagtg agactccatc tcaaaaaaaa aaaaaaaaaa 1620tttcctgcgg ccgc 1634 112 426 DNA Homo sapiens misc_feature (1)...(426) n = A,T,C or G 112nntttttttt ttttcctatg gatgtttagt tctaaaaagc accatttctc aaaaaaacta 60tccttcctcc attgaactgc ttttgcacct ctgtcaaaaa tcaattgggc atatttgtgt 120gagtctattt ctgggttctt tattctgttc cattgatcta cgtgtctatc cctctgtcaa 180taccacagtc ttgattactg tcactaaaaa gaaagtctta aaatagggta gacagactac 240ttccaattca ttcttctttt ttaaaattgt tttatctatt ttggtttctg tgcctttata 300tataantttt agaacaagct tgtctgtatc tataagaaat cttgctgtga ttctaatagg 360aattgcatta nacctataat cactttgggg agaattgaca tctttacgat gttgattntt 420ccaacc 426 113 727 DNA Homo sapiens 113agaattcggc acgaggcact aagatgtgtc ttaagaatca cagtgcgtgc ttcatccctt 60tattgaagaa cagaaaatta tgactactct acaaggtgga taatattttg gtacctgtgc 120ttgccacagc cctgttcctc aaagctgaat tgatagattt ctctttgact tccaagacct 180agcagttata aggcaccttg aaataaattg tttgtgcctg gaaatgcagg gagggcaata 240gctttgtaaa ttggtttaca tttttctcct tgaatttttc tagggtccta gtgcttccga 300atcatttaat ggcattgtcg gatatctttt acatttcaat tgcaatccat gaaattacat 360ttagaagatt cttagtactt aactgtagtc ttctccatga attacacgtt agaatagact 420ggcagcaact gaatatgcag caagtaagcc tctagcttat agtttcatcc ctacccctca 480tgcctgcgtg agtctgtaca gggatatgtg tgtgtgtgtg tgtgtgtgtg tgttagagag 540gaagaggaag agcagaatgt ctgtatacta catgctgcta aggtagtgaa taaatcagta 600atgcaatatt gtgggtccaa actactcttt gcactacttt atttacagta gtaaataaaa 660ttatttttat acaattgact accaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaagatg 720cggccgc 727 114 2291 DNA Homo sapiens 114gaacaatgaa gaaagcccca cagccactgt tgctgagcag ggagaggata ttacctccaa 60aaaagacagg ggagtattaa agattgtcaa aagagtgggg aatggtgagg aaacgccgat 120gattggagac aaagtttatg tccattacaa aggaaaattg tcaaatggaa agaagtttga 180ttccagtcat gatagaaatg aaccatttgt ctttagtctt ggcaaaggcc aagtcatcaa 240ggcatgggac attggggtgg ctaccatgaa gaaaggagag atatgccatt tactgtgcaa 300accagaatat gcatatggct cggctggcag tctccctaaa attccctcga atgcaactct 360cttttttgag attgagctcc ttgatttcaa aggagaggat ttatttgaag atggaggcat 420tatccggaga accaaacgga aaggagaggg atattcaaat ccaaacgaag gagcaacagt 480agaaatccac ctggaaggcc gctgtggtgg aaggatgttt gactgcagag atgtggcatt 540cactgtgggc gaaggagaag accacgacat tccaattgga attgacaaag ctctggagaa 600aatgcagcgg gaagaacaat gtattttata tcttggacca agatatggtt ttggagaggc 660agggaagcct aaatttggca ttgaacctaa tgctgagctt atatatgaag ttacacttaa 720gagcttcgaa aaggccaaag aatcctggga gatggatacc aaagaaaaat tggagcaggc 780tgccattgtc aaagagaagg gaaccgtata cttcaaggga ggcaaataca tgcaggcggt 840gattcagtat gggaagatag tgtcctggtt agagatggaa tatggtttat cagaaaagga 900atcgaaagct tctgaatcat ttctccttgc tgcctttctg aacctggcca tgtgctacct 960gaagcttaga gaatacacca aagctgttga atgctgtgac aaggcccttg gactggacag 1020tgccaatgag aaaggcttgt ataggagggg tgaagcccag ctgctcatga acgagtttga 1080gtcagccaag ggtgactttg agaaagtgct ggaagtaaac ccccagaata aggctgcaag 1140actgcagatc tccatgtgcc agaaaaaggc caaggagcac aacgagcggg accgcaggat 1200atacgccaac atgttcaaga agtttgcaga gcaggatgcc aaggaagagg ccaataaagc 1260aatgggcaag aagacttcag aaggggtcac taatgaaaaa ggaacagaca gtcaagcaat 1320ggaagaagag aaacctgagg gccacgtatg acgccacgcc aaggagggaa gagtcccagt 1380gaactcggcc cctcctcaat gggctttccc ccaactcagg acagaacagt gtttaatgta 1440aagtttgtta tagtctatgt gattctggaa gcaaatggca aaaccagtag cttcccaaaa 1500acagcccccc tgctgctgcc cggagggttc actgaggggt ggcacgggac cactccaggt 1560ggaacaaaca gaaatgactg tggtgtggag ggagtgagcc agcagcttaa gtccagctca 1620tttcagtttc tatcaacctt caagtatcca attcagggtc cctggagatc atcctaacaa 1680tgtggggctg ttaggtttta cctttgaact ttcatagcac tgcagaaacc ttttaaaaaa 1740aaatgcttca tgaatttctc ctttcctaca gttgggtagg gtaggggaag gaggataagc 1800ttttgttttt taaatgactg aagtgctata aatgtagtct gttgcatttt taaccaacag 1860aacccacagt agaggggtct catgtctccc cagttccaca gcagtgtcac agacgtgaaa 1920gccagaacct cagaggccac ttgcttgctg acttagcctc ctcccaaagt ccccctcctc 1980agccagcctc cttgtgagag tggctttcta ccacacacag cctgtccctg ggggagtaat 2040tctgtcattc ctaaaacacc cttcagcaat gataatgagc agatgagagt ttctggatta 2100gcttttccta ttttcgatga agttctgaga tactgaaatg tgaaaagagc aatcagaatt 2160gtgctttttc tcccctcctc tattcctttt agggaataat attcaataca cagtacttcc 2220tcccagaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2280aaaaaaaaaa a 2291 115 637 DNA Homo sapiens 115gcggccgcct tttttttttt ttttttttag tttgtaaaag tcttttattg tatccgtgcc 60acacatagtg aaaaataaca ctcctaaaaa aagaatgcta ccttttccac aacattttat 120tttaaataaa acttcaagta ctcttacgta ggtacaaaaa aaatctgatc tatttgcctc 180caacaggcca ccacaacaca cagtagataa aacacagtgg ttacaaacgt cttttaaatt 240tatttctgag gcaaggcaaa tgggagggaa atgtttctat gaaaaaatac tgtgtgcgta 300ggaaattgtc acaattttat tccacatgga tacaaatgat tatactttaa tttaggccct 360ggtggcttaa aattatataa caaaatagaa aaatggaaaa ctaatatccc ctacaccctg 420tttcaaaggc aggcactacc aagattaagg agacgccaca gtgttggtag aggataatta 480ctgtacagac tgtatagcta tcattacctt cagacgaaaa taaaatgcta caatcctcta 540aggcatgaac aataatgtct gcaaacaata tatacacata atacatattt taaaacaaga 600cttaatataa acaagaatga accctcgtgc cgaattc 637 116 664 DNA Homo sapiens 116gaattcggca cgagggcaga cacaactcag ctcccttact gtcctcaggc ccggctattt 60caagaattcc agaaaaagag tgcaccggcg tgtgcgggcc ggtgctgccc ggaaaacccg 120tgaagcaggc acgcacggcc cggatgcaag cacatctgtc ccctccccca aaggtctccc 180cagctttatt gatcgcgtgg gtgcgggtag ggatctaaat ttgtctccca gattttctct 240gaaatcgagt ctcttgggag tgaaggtcca tatgattaca ccacgtcctt agcagtcgcg 300ttgtgttcaa aatgggcatg ggtgctcgcg gcgcggatac tgagttcccc agagacgcgg 360agtcttttgc cccaggggct tattcttgtt ttctcaatgg aacaggtctt ctaatctccc 420caggaacatc tcagtaagta ggggtgtgcg tgtttgtgtg tgtgtcagtg tgtgtgtgta 480aatggttcct atgagctgac agtttggtat ttaaagaaca aatggacata agcacagaag 540tcatgacttt tctatggata agattgagat ttctgagatt tccaagacaa ggttgacctg 600tcacgggata gtattttcaa tccttctcat ttaaaaaaaa aaaaaaaaaa attcctgcgg 660ccgc 664 117 515 DNA Homo sapiens misc_feature (1)...(515) n = A,T,C or G 117tccttttttt ttttttttaa attgaattta tactttatta aaatcaaaca atacaagcct 60taaaatttga ttttntaaca ttataaaact atgcatcctt tatgaagttt cagttgatat 120ctgattaaaa aacactttgt ttcataagtg ttcagtgatt tatgaaactt ttaaaacaaa 180ttaagatggg atttattaca tcttatagcc attattggac ccattctaca ttttgaaaga 240ctaagagaat agggttagct atgggaaatg ctggctcact ggaagaatcc tgcattttcc 300aacttcccca ctcctagaag ttttgctaac aggaattgca actaggaatg cctcacctga 360aaaactaatt tcatacaact ttcattaagt agtttgacaa tctgtgaccc acaaatactt 420ccatagaatg gtagaattat ttataatcag aaatggatgg tgggggtata aagggaatca 480agagaggana gaaganggct aatggtggtt cttca 515 118 580 DNA Homo sapiens 118tttttttttt gcaacttgaa tatcattttt tattaatgaa ttgatttcca taaagcaaat 60ctttctctta aaatggcaga ttatgtgatc aaaaagcgat tcaaaaaagc ttccccctcc 120tcatgccaac cctcaagacc atgtgggatc cagctgaatc ctcagccctg ggactagact 180aaggttgagg gaaagagccg ttaactcatt cctaaccaga acaggctaat aggacactcc 240aaactcacac tacaaagaga ccacatgaac agtcgagtgt gctgggcagc tataagatgg 300tgcagactgg atgaatttgg cagagcatat tcatcaccat tactacaatg ctattcctaa 360ggtgtcctaa ttgtatgagc tacaaaatcg gtccctgttt ccattcttcc catctcacct 420gttggccctc ctgcagtagg tagccttggg agaagatcct gagcttttca tattctaccg 480ttttattttt gcattactgt ttggatgagt aaaatgtaat aacatgcttc tctctcttaa 540gtcccctaaa gagagtgtgt gtgtgtgtgt gtgtgtgtgt 580 119 928 DNA Homo sapiens 119gcggccgcag gaattttttt tttttttttt ttcttttcca taaattggtt tatttaaaca 60ttacccgaaa tcgtgaagga aaaaatattg gaaattacca aatgccctta aacaggcgaa 120tgattaggta acattttgtg catatgtatt aggttacgtt aataaagaaa ttttaaggat 180ataaagaaaa tgcttattga taaaggtaaa ggcaaaatag agaaagcaaa attatgtgaa 240cagtgtgaac tcaattccat aaaatgtata tgcatagaat atgaaaagaa attatagcaa 300aatatttatt attggttatc tcctggtctt aagattatac accatttttc cttttcttct 360tacttttttt ctgtgttata aatatgtaaa ataactaaag acatcctaag tagtaaaaat 420aatttgacct aaattgtgta tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tcaatgaaga 480attttttttt gtttttattt atgttttctt taggaaaata aaacatgtct agtaagaaag 540atgaaacaaa gaaagagttg gggtaagttc acatttttca aaccaacttg tgcttctaaa 600ataaaattct gcctctccac acactgggtt cctggaagct aaccaaaatc tgctcagtaa 660tattaactcc acttaaaaaa aggaagagaa catattgaac tgcattcact tatggtctgg 720gtgcttggaa gaaatcagct ggtgagtacc aaagtgatga ctgcatgttt ctatttgcat 780tttgaaaatt gacagataat tgaaaggaat cagcatatga aatttctcca aggaagccag 840ctgagaagcc cgaggaaccc tgcctacgga ggcctcctgg tgcctgaagt ctggttgcag 900aatgttctag aaccctcgtt ccgaattc 928 120 1853 DNA Homo sapiens 120gcggccgcag gaattttttt tttttttttt ttttttatgt tacaaatatt ttattgcaat 60tttttccctt taacaatgtc tggatatttt ggaattaata tctcggactt ctttctaatc 120cacattggtt catcttgttc attatgaaca gaggattcta ctttacaatg tactaaaatg 180ttgttatgta tttcaggacc attgaacatt caagttgttt atcattttct ttgaccacca 240acattgctgt aatgaatagg gatttaagag caaaagtaac gagaatactt gcttaaccac 300ttatgaaaac atatcataaa agtagaacaa tcaaaatggt ggatgccata gagaaagcaa 360ggtaacaaaa taggaagcct agggaccaat aaagtatata tacaaggatt tcctatatca 420caaaagtaac acttcaggta catggaaaaa gaatttcagt accaaaaggc acctcagtct 480cacatccaca cattcaaaaa taattaaaat tttacatgaa aagttggaaa cacaaaatga 540actagaaaaa caatatataa attaggacaa acactgcttt gcaatgggag gacctttgta 600aatctgacag taaaagtgaa gaaggagttt actagggatc tgtttgacat tacagaagca 660ttcatattca tacaccataa aacctcatat acaacattat aagacaaaca acagatttgg 720gggaaaaaca ctccaccatc tgtgaaagac tgtatgtcaa tagtcaaaaa gacttaatca 780gaaaatgata gcacccaaca gaagaaagac cttaatgggc ttggcccagt taaaaaatac 840caatcgatgc ctaagatacc tataaaaata tgtgcaaact ggataactaa aataatgcaa 900attaaagcaa tttaatgcca ttatttttcc tgtatctgaa aggcaaagat ttaaaagaac 960cataatccct ggtgcaggcc caggcataga tcagcagccc ctcatctgtg gccggtggga 1020gggagagttg cctggtctat ctggaagagt ggccacccgg gccatttgga ccaaaggccc 1080taaagcatat atgcctttgg ggcattttcc tttgtttggc agtttcccct gacttttccg 1140cagtagacgt gggctctgga ctcctctcct gatgttcccc aggtcccgcc agcctgccca 1200ccacttgggc cgttaacttc tctacatgac gtggggtctc aagggactgg aggtcccaca 1260gacatcactg agacaactag cagggctccc cagaagctcc caaacagtct ctcatgtgcg 1320tcccttgcac cgcccccccg acccccaata ccatgcccat ttctcggagt gacaatcgag 1380gctagtctga attccctgag cctcactgag cgtgcccagt cctgtgccac tcttccaagc 1440cctaaccccc acgggtgccc acctggtgcc tcccacctct gcacccagat gagaatcatg 1500tcatgtgcat cagcgactgc cggggacagg cagcccacac aagtcctcaa cacaaccagc 1560cgaatctcag tctgataagg ctcagctcag acctcagccc cactctcata ataaatcagt 1620gaaaaaagaa ggaagaaaaa tggcaaaagc aaggaaacct gattaaaaaa atgaggggga 1680gatggaatga gtatatctag aaagttctaa taatgcagaa cctacaaata agttaacctg 1740acaggaaaaa tgtgtgcatg tacgtgtgtg tgtgtgtgtc tgtgtgagcg cagggagaga 1800agtgatttgc tgaaggtcaa gggggccgga gcaaggctcc tcgtgccgaa ttc 1853 121 709 DNA Homo sapiens 121gtttggagac tgtgtccaag gcgactggtg ccccatctct gggggactat gctcggcccg 60cctacatcgt cacgccctac tggccacctg tccagagcat caggtcacct gggaccccat 120cgatggacgc gttatcggct cagctctaca attccttatc cctcgactcc cttccttccc 180cacccagaga acctctaaga ccctcaaagt cctcaccccg ccgaccactc atacaacccc 240caacattcca ccctccttct tccaagccat gcgaaaccat tcccccttcc gcaacggata 300tatggagccc accctcgggc agcagctccc agccttgtct ttccccgacc ccggcctccg 360gccccaaaac ttatacaccc tctggggaag ctccgttgtc tgcatgtacc tctatcagct 420ctcccccccc atcacctggc ccctcctgcc ccatgtaatc ttctgccacc ctggtcagct 480cggggccttc ctcactaagg tcccctataa gcgaatggag gagcttctct ataaaatctt 540ccttaatacc ggggccctta taatactacc tgaagattgc ctgcccacca cccttttcca 600gcccacaagg gcgcccgcca cgttaacagc ctggcaaaat ggcctccttc ctttccaagc 660tgcaatcacc accccaggcc ttatttggac atttaccgat ggtacaccc 709 122 241 DNA Homo sapiens misc_feature (1)...(241) n = A,T,C or G 122agggaggctg gggccaggtg tcagccctag gcctccatcc aacaccgtgg aaatgttgct 60gccctcttct tggcgctgac cccaagattg gggtttcctt tctgccgctc cctccactgt 120tgtttatcta actgggcccc cactccaggt ccagagggac tgtgctcact gcacagacat 180cactcagctt ccgctcccca gtcctgcaga gctgttgcca ggtgccagtg ggggagngga 240g 241 123 448 DNA Homo sapiens 123ctcgaggcca agaattcggc acgaggtttc ttctacctct gttatctaag cagagggaag 60taaacttctc accgcccccc acccctcact gcccccgatt acactagaat tgctttcgcc 120aaattgtagt tgaagctaag gaaggggaat ctggcccctg ctgggagagg gaactggaat 180gccacacaag gcaaggcctg cttccttcct tcccctctgc tgctgctgcc tcggaacgct 240gcagcccagg cttcctccca cagtggccct tggaagcagg ccgcagagta gacagctgct 300ccttttggaa gagtcagtcc cctgtgtttt ctgaactgtt tttcctagca tgtatgtggg 360tagagctttc atgcatctct agtaataata agctgaaatt agtttttttt ttaattctcc 420aatttaaaac ttttaattaa gcggccgc 448 124 1821 DNA Homo sapiens 124gaattcggaa cgagggaggc attttgtggc cttaaaacgg ggtgttcagg gtcagccctc 60agggtgctgg ggcccttcca tcccttgtcc ccttcaggtt ggtgaaaagg actccggggg 120ccaggtgctg tatagcagct tatggaagtc tcagctgggc tatcctgccc ttgggagcac 180agacaggctc ctagggtgct gagtgaagcc tgaagaccaa gccccctcct cctggaatgc 240tccttccacc cctacctctc agagatgggc ctgacacctc tttctcattc attctccttt 300tccctgtgct ctgggaaagc ccctggctca ggctgtcaga gtgaggatgg acctcaaaag 360tttgatcccc tcgtgcagat gaagaagctg aagcccagag tgcggaaggg gagtggccca 420aggtcacaca gctagtttga gtagagccag tcttgggaga gccaagtact acagccctgg 480gggtgtcaca ccgcttgtca ctgcccctga ggtctcctgc caaacaactg cagggagttt 540ggctaacagt cctgtgtcca gggtgccggt ggggatgtta tagatgttgc tgggatcctg 600ccctcggctc caaattctgg cctctcatcc caggctgcag acccttctgc cccatgacag 660gcctgggtgc cacacagagg tggccaccct cccaccacag tgtctgcagc tgctgccctt 720ctcccaggcc cccagacaga agagaccctg tttcccctcc tctcccctgt gacttcacaa 780gagcttgggc ttggagtgaa ggtcagcatg ttctcatgtg ctcatcctct tggtttcccc 840aaagaccggg agggtcacgg atggggcgtg cagaatcctt gtgttttttc tcgctgggca 900gcttgagggg ctggggagta ttcccagggt ctttgctctg gagagtccct gcagagccac 960tggctgaggt tgggttcagg gttcagcgga gtcctccatg cttccaaagg ccgggaagca 1020cccgcctctc tatcgagtca gtgctgtgcg tgtgtgtctg agaatgtgtg tgatgtgtgg 1080agtgtgcgtg tgtttgtgtg tgtgtgtgtg tgtgttgggg cagaaggacc actctttcct 1140ggggatccct tgacccttat aactagaagg gaccttaggg agcatctaag ctggtgcccc 1200cattgtacag gcgaggtcca gagggatggc atctgcccac cccacccctt gccctcttgt 1260tgcctgcact catttcccag ggaccctcct aggataggaa tgccctcctt cctggccccc 1320tcccgccatc ctcccagcca cccacataat caccatctca gcccaactct ggtggccctc 1380taggtctcca tgcattcttc ctgccctaga gtagccagct caccaaggcc tttatcccca 1440gcccaggaga agggtcaggg agggaagggg ctgcaccagc cctgagacct caaagacttg 1500ggagaaaagc caaaactcct catgcccagg cccacatgtc tgaccacccc agcccacccc 1560gccaccaagg taaaagcaca acaggagacc cccttattaa tgggtgaaat gattggggtt 1620gtttttttag tcacacagcc ccatcctcac ccctttgcct tgctgtctgt ctccacccca 1680gcctctgttc cccatttgcc tctctttcac ctccaagccc ccaaatgtaa cctctagttg 1740cggacgcggt tgttctatca ataaagctgc agtgttctag caaaaaaaaa aaaaaaaaaa 1800aaaaaaaaaa agcgcggccg c 1821 125 540 DNA Homo sapiens misc_feature (1)...(540) n = A,T,C or G 125tttttttttt tcnttcataa ttgtaattaa tttagcataa gcaaagaaat gaccttagga 60acatatttag gttttaagat agatttctat ntaatgggcc tgaaaggcat tttgatctga 120atttattttc caacgatttc aaatataatt tgtcatctgt gtgtagacat atacgggcat 180gaacacacat tcacccacac atacaaaaac acttgctttc tatcagatca gggtaatttt 240tttattgcag gtctctttta atattggcta gcagaaaacc tatccccaac ctaacagatt 300acacacacac acacacacac acacacacac acacagagct atttttccac acttcctcac 360agtgaaaagc tctctaacaa gataccagaa ggtcgagaga gacaatgctt ttatggctgg 420gccttgagga caattctggt tgcatttaaa tctcagtgcc aaatgcacta ggttccctgc 480cgttataatt tttggatcag tctcttctga aatcangtca cagagaaaac aggatgattt 540 126 2490 DNA Homo sapiens 126gttcgtagtt cggctctggg gtcttttgtg tccgggtctg gcttggcttt gtgtccgcga 60gtttttgttc cgctccgcag cgctcttccc gggcaggagc cgtgaggctc ggaggcggca 120gcgcggtccc cggccaggag caagcgcgcc ggcgtgagcg gcggcggcaa aggctgtggg 180gagggggctt cgcagatccc cgagatgccg gagttcctgg aagacccctc ggtcctgaca 240aaagacaagt tgaagagtga gttggtcgcc aacaatgtga cgctgccggc cggggagcag 300cgcaaagacg tgtacgtcca gctctacctg cagcacctca cggctcgcaa ccggccgccg 360ctccccgccg gcaccaacag caaggggccc ccggacttct ccagtgacga agagcgcgag 420cccaccccgg tcctcggctc tggggccgcc gccgcgggcc ggagccgagc agccgtcggc 480aggaaagcca caaaaaaaac tgataaaccc agacaagaag ataaagatga tctagatgta 540acagagctca ctaatgaaga tcttttggat cagcttgtga aatacggagt gaatcctggt 600cctattgtgg gaacaaccag gaagctatat gagaaaaagc ttttgaaact gagggaacaa 660ggaacagaat caagatcttc tactcctctg ccaacaattt cttcttcagc agaaaataca 720aggcagaatg gaagtaatga ttctgacaga tacagtgaca atgaagaagg aaagaagaaa 780gaacacaaga aagtgaagtc cactagggat attgttcctt tttctgaact tggaactact 840ccctctggtg gtggattttt tcagggtatt tcttttcctg aaatctccac ccgtcctcct 900ttgggcagta ccgaactaca ggcagctaag aaagtacata cttctaaggg agacctacct 960agggagcctc ttgttgccac aaacttgcct ggcaggggac agttgcagaa gttagcctct 1020gaaaggaatt tgtttatttc atgcaagtct agccatgata ggtgtttaga gaaaagttct 1080tcgtcatctt ctcagcctga acacagtgcc atgttggtct ctactgcagc ttctccttca 1140ctgattaaag aaaccaccac tggttactat aaagacatag tagaaaatat ttgcggtaga 1200gagaaaagtg gaattcaacc attatgtcct gagaggtccc atatttcaga tcaatcgcct 1260ctctccagta aaaggaaagc actagaagag tctgagagct cacaactaat ttctccgcca 1320cttgcccagg caatcagaga ttatgtcaat tctctgttgg tccagggtgg ggtaggtagt 1380ttgcctggaa cttctaactc tatgccccca ctggatgtag aaaacataca gaagagaatt 1440gatcagtcta agtttcaaga aactgaattc ctgtctcctc caagaaaagt ccctagactg 1500agtgagaagt cagtggagga aagggattca ggttcctttg tggcatttca gaacatacct 1560ggatccgaac tgatgtcttc ttttgccaaa actgttgtct ctcattcact cactacctta 1620ggtctagaag tggctaagca atcacagcat gataaaatag atgcctcaga actatctttt 1680cccttccatg aatctatttt aaaagtaatt gaagaagaat ggcagcaagt tgacaggcag 1740ctgccttcac tggcatgcaa atatccagtt tcttccaggg aggcaacaca gatattatca 1800gttccaaaag tagatgatga aatcctaggg tttatttctg aagccactcc actaggaggt 1860attcaagcag cctccactga gtcttgcaat cagcagttgg acttagcact ctgtagagca 1920tatgaagctg cagcatcagc attgcagatt gcaactcaca ctgcctttgt agctaaggct 1980atgcaggcag acattagtca agctgcacag attcttagct cagatcctag tcgtacccac 2040caagcgcttg ggattctgag caaaacatat gatgcagcct catatatttg tgaagctgca 2100tttgatgaag tgaagatggc tgcccatacc atgggaaatg ccactgtagg tcgtcgatac 2160ctctggctga aggattgcaa aattaattta gcttctaaga ataagctggc ttccactccc 2220tttaaaggtg gaacattatt tggaggagaa gtatgcaaag taattaaaaa gcgtggaaat 2280aaacactagt aaaattaagg acaaaaagac atctatctta tctttcaggt actttatgcc 2340aacattttct tttctgttaa ggttgtttta gtttccagat agggctaatt acaaaatgtt 2400aagcttctac ccatcaaatt acagtataaa agtaattgcc tgtgtagaac tacttgtctt 2460ttctaaagat ttgcgtagat aggaagcctg 2490 127 1478 DNA Homo sapiens 127aagcttggca cgaggataac ttctacattt tgaaaatttt atgtcaatta tttaatagaa 60tatctctaaa tttaggtttg tctcattttt caatgtaatt ggattcaggt tacgcatttt 120tgatagatta gagtggtgct gtgttattct tattgcacag gtctgttggg ttgagtgggg 180tgagttaaat cattcctttt tggcctctca taatactgaa tcaagtgaaa gttggcctga 240gtcatcagaa gacttgtctc ggctgaatgt acaaggtgct cactgacata cagatccaaa 300gttgagtcgg actggtctga ctgttggctg aaagctcacc tggggctgcc agaggtcttc 360aacctagcgt ctccacgtaa cttaagcttc ttatatcatg tgcctaaatt ctgagacaga 420ggaatagaga agagagaaag gaagagcaag agagagaagg ggagttccga gtgtccattc 480caagaaactg aggtggaaac tgcaaggctt cttataccag agcattactt tttgtaccag 540aacattactt ccagtgtatt ctatctgtaa agcaagttat atttagttca catcttgatg 600tgagaaatag cattgtgtac agggaaaaag aacttgatag ctatttttgt agactatctg 660ataaagatgt ttctgggctg agttaataat gctatgttgg ctatttattt ctgattttct 720agttctgtca tttcttctac atttattagt tagtctttgt gtcagttggg gttccctagg 780gaaacagaac caataggata tatctatatc tttacctatg tcccatacag atacacacac 840acacacacac acacacacac acatccaatc cacacacaca tgtacattca atctgttgat 900agcctgacta gaacaatagg caaaggcaag gggaaattcg tatctctacc tgactgcttc 960agctgaaata tcaatcagtc tcttcctgcc ctacactggg accaacatca tgagccctct 1020ggttcccaga actgtaacac tggctttcct ctttccgggg tctccagctt tcagacagta 1080gaatcatgag acttctcagc ctccttaacc atgtgagcca atgccttata acaaatatcc 1140tacaaacata tatatataaa tgtatacata caaatataat aatatcatac aaatatatat 1200atttatatgt atacatgtaa ttacatttaa gaacatttaa ggctatttac atgtaaagaa 1260aggaaaaata atgtaaatat ttgttttcac ctgaaataaa tgtcagacac tgtctttgtt 1320taaagaaata gtcctcttaa actttgggca atgctgccaa ttacattaac ttacaatgtt 1380atttcaattg catcaccaga gtaaaatctt agagtattat ttttatctaa taaattaata 1440acatccaaaa aaaaaaaaaa aaaaattcct gcggccgc 1478 128 376 DNA Homo sapiens misc_feature (1)...(376) n = A,T,C or G 128catcactata gggcgaattg gcgtaccggg ccccccctcg agtttttttt tttttttttt 60ttttttaacc aagctaaggc actaccagaa atttcaagga taatgattct ggccactaga 120gaatgaaaac agcattggca atacttattt ttaatcatat ctagttgaca tagaaacaaa 180caatcttttt ctagggaaaa aaaagccaat tctgtgttac atccttgtta gaacattgtg 240caattcaaat aagcgagtct gcctcatctt taatagaaat tctctcaaaa agggtttagt 300gaccactaca gtcaatttta aaaacaaatt agctgaattc cctcttactc tgaagtgnta 360tttcaagtct gggggt 376 129 903 DNA Homo sapiens 129gaattcggca cgaggtgtca gctcagtgca tcccaggcag ctcttagtgt ggagcagtga 60actgtctgtg gttccttcta cttggggatc atgcagagag cttcacgtct gaagagagag 120ctgcacatgt tagccacaga gccaccccca ggcatcacat gttggcaaga taaagaccaa 180atggatgacc tgcgagctca aatattaggt ggagccaaca caccttatga gaaaggtgtt 240tttaagctag aagttatcat tcctgagagg tacccatttg aacctcctca gatccgattt 300ctcactccaa tttatcatcc aaacattgat tctgctggaa ggatttgtct ggatgttctc 360aaattgccac caaaaggtgc ttggagacca tccctcaaca tcgcaactgt gttgacctct 420attcagctga tcatgtcaga acccaaccct gatgacccgc tcatggctga catatcctca 480gaatttaaat ataataagcc agccttcctc aagaatgcca gacagtggac agagaagcat 540gcaagacaga aacaaaaggc tgatgaggaa gagatgcttg ataatctacc agaggctggt 600gactccagag tacacaactc aacacagaaa aggaaggcca gtcagctagt aggcatagaa 660aagaaatttc atcctgatgt ttaggggact tgtcctggtt catcttagtt aatgtgttct 720ttgccaaggt gatctaagtt gcctaccttg aatttttttt taaatatatt tgatgacata 780atttttgtgt agtttattta tcttgtacat atgtattttg aaatctttta aacctgaaaa 840ataaatagtc atttaatgtt gaaaaaaaaa aaaaaaaaaa aagatcttta attaagcggc 900cgc 903 130 1140 DNA Homo sapiens misc_feature (1)...(1140) n = A,T,C or G 130ctggcgctgc tggggctcgg cgncggcctt tgtctgcggg cacggccgct gcggtgctca 60ggaacagccc atggaagaat catatgaaga ggtggtgact gaggtcgtaa gcaggagtgg 120acatgtttgg atttccaaca gctaccctgc tggactgtca tggaagatat gcccagaatg 180tagcgttctt caatgtgatg actgaagccc accacaaata tgaccactct gaggctacag 240gatcctcaag ctgggatatc caaaattctt tcagaagaga gaagctggaa caaaaatccc 300cagattcgaa gacactacag gaagattcac ctggagtgag acaaagggtc tatgagtgcc 360aggagtgtgg aaaatccttc cggcaaaaag gtagtctaac gttacatgag agaatccaca 420ctggtcaaaa gccttttgag tgcacccact gtggaaaaag cttcagggcc aaaggcaatc 480ttgttacaca tcaacggata cacacgggag agaagcctta tcagtgcaag gagtgtggga 540aaagcttcag tcaacgaggt agtctcgctg tccacgagag actccacact ggacagaaac 600cctacgagtg tgctatttgt cagagaagct tcaggaatca gagtaacctt gctgttcaca 660ggagagttca cagtggtgag aagccctata gatgtgatca gtgtggaaaa gccttcagtc 720agaaaggaag cttaattgtt cacatcagag tccacacagg cctgaagccc tatgcctgta 780cccagtgcag gaagagtttc cacaccaggg ggaattgtat tctgcatggc aaaatccaca 840caggagagac accctatctg tgcggccagt gtggaaaaag cttcacccag agagggagtc 900tggctgtgca ccagcgaagc tgctcacaga ggctcaccct ttgaccactt tcctgaagag 960aagttctctt tatgaattaa gagtacaaaa tcctctgaga tgaagcaacc tatccagttc 1020tatggaatga atggagaatc tttcagaaag accatcattg ggtagggcaa actgattttt 1080ttcctttccc ccaaaagagt atgaaaaata aaggtcttgt ttattatcat taaaaaaaaa 1140 131 1337 DNA Homo sapiens 131aagcttggca cgagggcagt ctcatgataa tccaagtaac tctctgtgtg aagcaccttt 60gaacatttca cgtgatactt tgtgttcaga tgaatacttt gctggtggct tacactcatc 120ttttgatgat ctttgtggaa actcaggatg tggaaatcag gaaaggaagt tggaaggatc 180cattaatgac attaaaagtg atgtgtgtat ttcttcactt gtattgaaag caaataatat 240tcattcatca ccatctttca ctcacctcga taaatcaagt cctcagaaat ttctgagtaa 300tctttcaaag gaagaaataa acttgcaaag aaatattgca ggtaaagtag tcacccctca 360ccaaaagcag gctgcaggta tgtctcagga gacgtttgaa gagaagtatc gtttgtctcc 420taccttatct tcaacaaaag gccacctttt gatacattca agacccagga gttcctcagt 480aaagagaaaa agagtatcac atggctccca ttcacctccg aaggaaaaat gcaagagaaa 540gaggagcacc aggagatcta tcatgccgag gctgcagctg tgcaggtcgg aaggcaggct 600gcagcacgtg gcgggacctg ccctggaggc tcttagctgt ggggagtctt catatgatga 660ctatttttca cctgataatc ttaaggaaag gtattcagag aatcttcctc ctgaatctca 720gctgccatca agccctgctc agttgagctg cagaagtctt tctaagaagg agagaacaag 780catatttgaa atgtctgatt tttcctgcgt tggcaaaaaa accagaacag ttgacattac 840caatttcaca gcaaaaacca tctccagtcc tcggaaaact ggaaatggtg aaggccgtgc 900aacttcgagt tgcgtgactt ctgcccctga agaagcccta aggtgttgta gacaggctgg 960gaaagaagac gcatgcccag agggaaatgg cttttcttac accattgagg accctgctct 1020tccaaaagga catgatgatg atttaactcc tttggaagga agccttgaag aaatgaaaga 1080agcggttggt ctgaaaagca cacagaacaa aggtaccact tccaaaatat caaactcctc 1140tgaaggcgaa gcccagagtg aacatgagcc atgttttata gttgactgta acatggagac 1200atctacagaa gagaaggaaa acttacccgg aggatacagt ggaagtatgt gaatctcctt 1260ttccaagtca ccttcgctaa ataaacatgt aacagtgcat ccataaaaaa aaaaaaaaaa 1320aaaattcctg cggccgc 1337 132 492 DNA Homo sapiens misc_feature (1)...(492) n = A,T,C or G 132aataagcttg cggccgcgan nccggagcct gcccgcgcgc ccccggaacc cgcgcccccg 60gccgaggcca ccggggaccc ggcnccgtcc cgcccctgct gcccccgagc cggcggcctc 120ncccgngggg ccggagganc ctggagagcc cgcggggctg ggggagctcg gggagcctgc 180gggaccgggg gagcccgaag ggccanggga tcccgcggng gngccagcgg aggcggagga 240gcaggcggtg gaggcgaggc aggaagagga gcaggacttg gatggtgaga aggggccatc 300atcggaaggg cctgacgagg angacngaga aggcttctcc ttnaaataca gccccggnaa 360gctnanggga aaccagtacn ngaagatgat gaccaaagag ganctggang aggagcagat 420gatnganctg acctntgacc tcacttccct gtagcaagtt ccttangtcc tgagccacaa 480atattcttgc aa 492 133 693 DNA Homo sapiens 133ctcgaggcca agaattcggc acgaggctga gagggtgggt ctgagtcccc acaatgtctg 60aagctgcccc tgggattctc aggccaacct gccaacagca agcggatttt cttgcaagat 120cagggacccc atttctgcag ccagtgtctc ctgggtgcct tctgaggact cccaccccca 180tcccagtatc tcatctgtcc cctctcctgg ggcttaagtg ggttgcttcc aggcagaagc 240agccaaggac cgattccagg cactttctgt agcaaatgac tgtgaattac gacttctctt 300gcccttcttc tagcagtctg tgcctcctct ctgaccagtt tggagggcac tgaagaaagg 360caagggccgt gctgctgctg ggcggggcag gagaggagcc tggccagtgt gccacattaa 420atacccgtgc aggcgcggag aagcaaccgg cacccccttc cggcctgaaa gccctccctg 480caagaaggtg tgcaggagag aagaggcccc ggcatgggga tctgggttct agagggcatg 540tgatgactgt aaatgttcac tgggtgggta gggagtggta tccagtgttc aagtgcagaa 600atctttggct ttgctaccag ttccatatga tgagaaataa acgttcgctg aggttttgtt 660tcaaaaaaaa aaaaaaaaaa aaaaggcggc cgc 693 134 1855 DNA Homo sapiens 134cctcaggccg gctgtgaacg tagttcctga gagatagcaa acatgcccaa cagtgagccc 60gcatctctgc tggagctgtt caacagcatc gccacacaag gggagctcgt aaggtccctc 120aaagcgggaa atgcgtcaaa ggatgaaatt gattctgcag taaagatgtt ggtgtcatta 180aaaatgagct acaaagctgc cgcgggggag gattacaagg ctgactgtcc tccagggaac 240ccagcaccta ccagtaatca tggcccagat gccacagaag ctgaagagga ttttgtggac 300ccatggacag tacagacaag cagtgcaaaa ggcatagact acgataagct cattgttcgg 360tttggaagta gtaaaattga caaagagcta ataaaccgaa tagagagagc caccggccaa 420agaccacacc acttcctgcg cagaggcatc ttcttctcac acagagatat gaatcaggtt 480cttgatgcct atgaaaataa gaagccattt tatctgtaca cgggccgggg cccctcttct 540gaagcaatgc atgtaggtca cctcattcca tttattttca caaagtggct ccaggatgta 600tttaacgtgc ccttggtgat ccagatgacg gatgacgaga agtatctgtg gaaggacctg 660accctggacc aggcctatag ctatgctgtg gagaatgcca aggacatcat cgcctgtggc 720tttgacatca acaagacttt catattctct gacctggact acatggggat gagctcaggt 780ttctacaaaa atgtggtgaa gattcaaaag catgttacct tcaaccaagt gaaaggcatt 840ttcggcttca ctgacagcga ctgcattggg aagatcagtt ttcctgccat ccaggctgct 900ccctccttca gcaactcatt cccacagatc ttccgagaca ggacggatat ccagtgcctt 960atcccatgtg ccattgacca ggatccttac tttagaatga caagggacgt cgcccccagg 1020atcggctatc ctaaaccagc cctgttgcac tccaccttct tcccagccct gcagggcgcc 1080cagaccaaaa tgagtgccag cgaccccaac tcctccatct tcctcaccga cacggccaag 1140cagatcaaaa ccaaggtcaa taagcatgcg ttttctggag ggagagacac catcgaggag 1200cacaggcagt ttgggggcaa ctgtgatgtg gacgtgtctt tcatgtacct gaccttcttc 1260ctcgaggacg acgacaagct cgagcagatc aggaaggatt acaccagcgg agccatgctc 1320accggtgagc tcaagaaggc actcatagag gttctgcagc ccttgatcgc agagcaccag 1380gcccggcgca aggaggtcac ggatgagata gtgaaagagt tcatgactcc ccggaagctg 1440tccttcgact ttcagtagca ctcgttttac atatgcttat aaaagaagtg atgtatcagt 1500aatgtatcaa taatcccagc ccagtcaaag caccgccacc tgtaggcttc tgtctcatgg 1560taattactgg gcctggcctc tgtaagcctg tgtatgttat caatactgtt tcttcctgtg 1620agttccatta tttctatctc ttatgggcaa agcattgtgg gtaattggtg ctggctaaca 1680ttgcatggtc ggatagagaa gtccagctgt gagtctctcc ccaaagcagc cccacagtgg 1740agcctttggc tggaagtcca tgggccaccc tgttcttgtc catggaggac tccgagggtt 1800ccaagtatac tcttaagacc cactctgttt aaaaatatat attctatgta tgcgt 1855 135 2559 DNA Homo sapiens 135ggaattccgg aattccgaat gcgtcggaaa gagcgggagt gtgcgccgcg cgagagtggg 60aggcgaaggg ggcaggccag ggagaggcgc aggagccttt gcagccacgc gcgcgcgctt 120ccctgtcttg tgtgcttcgc gaggtagagc gggcgccggc agcggcgggg attactttgc 180tgctagtttc ggttgccggc agcggcgggt gtagtctcgg cggcagcggc ggagacacta 240gcactatgtc ggaggagcag ttcggcggga cggggcggcg gcacgcgaac ggcggcggta 300ggcgctcggc gggcgacgag gagggagcca tggtggcggc gacacagggg gcagcggcgg 360cgcgggaagc ggacgcggga ccgggggcgg aaccgcgtct ggaggcaccg aagggcagcg 420ccgagtcgga gggggcgaag attgacgcca gtaagaacga ggaggatgaa gggaaaatgt 480ttataggagg ccttagctgg gacactacaa agaaagatct gaaggactac ttttccaaat 540ttggtgaagt tgtagactgc actctgaagt tagatcctat cacagggcga tcaaggggtt 600ttggctttgt gctatttaaa gaatcggaga gtgtagataa ggtcatggat caaaaagaac 660ataaattgaa tgggaaggtg attgatccta aaagggccaa agccatgaaa acaaaagagc 720cggttaaaaa aatttttgtt ggtggccttt ctccagatac acctgaagag aaaataaggg 780agtactttgg tggttttggt gaggtggaat ccatagagct ccccatggac aacaagacca 840ataagaggcg tgggttctgc tttattacct ttaaggaaga agaaccagtg aagaagataa 900tggaaaagaa ataccacaat gttggtctta gtaaatgtga aataaaagta gccatgtcga 960aggaacaata tcagcaacag caacagtggg gatctagagg aggatttgca ggaagagctc 1020gtggggaatt ccggaattcc tcagaggcag gagaaggctt ggagctaccc ccaaactcaa 1080tccactgttg gcagctgagc gtgtagtagg gtggtcctag ccatacagaa ccacttctct 1140gtctccctcc tcttccctgg ttcgtccagc cccagtccat cagggaccac ctgggcagcc 1200tcccagagat gggatcgggt tggggctaag ggcatcgggt ctgtcgcagc caggggtgca 1260ggaggatcgc tgtgctgtga gccgttcagc tggctcccga cgaaggaggc acggaaccag 1320acagcgcggc gagggcgaga gcgctgcagg caaggcgtag gccccgcggc ggatcttgcc 1380gaagagcagg acaggctccg agtcctggaa ggggtagtgg ccggccagca tggtgaagag 1440cgccacgccc aggctccaga catcggctgc cttgcccgag tatgaggccc gtgagctgag 1500tatctcaggt cccacgtagg ctggcgacgc gtgcttgtcc acagggaatc atctggccca 1560gtcagcacgc aggagtcctc caggttctcc agcaccagct tcttcctggg acatggggag 1620aaacagaagg gtcaggtcct acccagaacc cccatgctat cacccttgtg gcacccactt 1680tccaagtcgc tgctggcctt tgacagacac aagccagtcc tgtgatgtct gatcctgttt 1740tacagatacc caagcccagg ctcagagagg ttaagtcatt taaggccaca gagcaattaa 1800atttaaacta aaattctgaa aggaatacat ttttcaacag agtccttggg gagggggctg 1860atggggctga gagggttaag cctctcttaa accagctaca aacttagggt ccaggcaggt 1920aataagatga gagaaacagg aagtgtgcct gacatctcag cacaagcgct acctaaaaag 1980ggtacacaac gcattctagg gtttaccaag tgcctgctgt gttcctggcc cttgacccag 2040ctcattacct ggctcacctc attctatcta gctacagcct gcaaggaaga caccatttta 2100cagctgtaga gcatgggcct gggatgggaa cgctggctgg cagatactca gagccagtgc 2160tgtgacccac cctctcagtt cccaagatgg ccccacattc ccattgtttt ccccaagaga 2220agccaggaat tgtattttaa tgaaaaggtc cccatttaaa aaatattggc aaaccagttt 2280atataaaaaa cacaaacagg taagcagggc aaaaaaaaaa gtgtgtaagg ctgggcgcgg 2340tgctcatgcc cggtaatcct agcactttgg gagcgcgagg cagggggatc acttgagttc 2400aggagttcaa gaccagcctg ggcaacacgg taaaaaccta tctctacaaa aaatacgaaa 2460attagcaggc atggtgattc gcacctgtag tcccagctac ttgggaggct gatcttgaac 2520tcctgaactc aagtgatccc cctgcctcgg ccggaattc 2559 136 895 DNA Homo sapiens 136agagacttaa gtctaaggca ctgagcgtat catgttaaag atgagcgggt ggcagcgaca 60gagccaaaat cagagctgga acctgaggag agagtgttca agaaggaagt gtatcttcat 120acatcaccac acctgaaagc agatgtgctt ttccagactg atccaactgc agagatggca 180gctgagtcat tgcctttctc ttcggacact gtcagctggg agctggaagc ctggtatgag 240gacctgcaag aggtcctgtc ttcagatgaa aatgggggta cctatgtttc acctcctgga 300aatgaagagg aagaatcaaa aatcttcacc actcttgacc ctgcttctct ggcttggctg 360actgaggagg agccagaacc agcagaggtc acaagcacct cccagagccc tcactctcca 420gattccagtc agagctccct ggctcaggag gaagaggagg aagaccaagg gagaaccagg 480aaacggaaac agagtggtca ttccccagcc cgggctggaa agcagcgcat gaaggagaaa 540gaacaggaga atgaaaggaa agtggcacag ctagctgaag agaatgaacg gctcaagcag 600gaaatcgagc gcctgaccag ggaagtagag gcgactcgcc gagctctgat tgaccgaatg 660gtgaatctgc accaagcatg aacaattggg agcatcagtc ccccacttgg gccacactac 720ccacctttcc cagaagtggc tactgactac cctctcacta gtgccaatga tgtgaccctc 780aatcccacat acgcaggggg aaggcttgga gtagacaaaa ggaaaggtct cagcttgtat 840atagagattg tacatttatt tattactgtc cctatctatt aaagtgactt tctat 895 137 1860 DNA Homo sapiens 137cgtgaacggt cgttgcagag attgcgggcg gctgagacgc cgcctgcctg gcacctagga 60gcgcagcgga gccccgacac cgccgccgcc gccatggagt ccgagaccga acccgagccc 120gtcacgctcc tggtgaagag ccccaaccag cgccaccgcg acttggagct gagtggcgac 180cgcggctgga gtgtgggcca cctcaaggcc cacctgagcc gcgtctaccc cgagcgtccg 240cgtccagagg accagaggtt aatttattct gggaagctgt tgttggatca ccaatgtctc 300agggacttgc ttccaaagca ggaaaaacgg catgttttgc atctggtgtg caatgtgaag 360agtccttcaa aaatgccaga aatcaacgcc aaggtggctg aatccacaga ggagcctgct 420ggttctaatc ggggacagta tcctgaggat tcctcaagtg atggtttaag gcaaagggaa 480gttcttcgga acctttcttc ccctggatgg gaaaacatct caaggcctga agctgcccag 540caggcattcc aaggcctggg tcctggtttc tccggttaca caccctatgg gtggcttcag 600ctttcctggt tccagcagat atatgcacga cagtactaca tgcaatattt agcagccact 660gctgcatcag gggcttttgt tccaccacca agtgcacaag agatacctgt ggtctctgca 720cctgctccag cccctattca caaccagttt ccagctgaaa accagcctgc caatcagaat 780gctgctcctc aagtggttgt taatcctgga gccaatcaaa atttgcggat gaatgcacaa 840ggtggcccta ttgtggaaga agatgatgaa ataaatcgag attggttgga ttggacctat 900tcagcagcta cattttctgt ttttctcagt atcctctact tctactcctc cctgagcaga 960ttcctcatgg tcatgggggc caccgttgtt atgtacctgc atcacgttgg gtggtttcca 1020tttagaccga ggccggttca gaacttccca aatgatggtc ctcctcctga cgttgtaaat 1080caggacccca acaataactt acaggaaggc actgatcctg aaactgaaga ccccaaccac 1140ctccctccag acagggatgt actagatggc gagcagacca gcccctcctt tatgagcaca 1200gcatggcttg tcttcaagac tttctttgcc tctcttcttc cagaaggccc cccagccatc 1260gcaaactgat ggtgtttgtg ctgtagctgt tggaggcttt gacaggaatg gactggatca 1320cctgactcca gctagattgc ctctcctgga catggcaatg atgagttttt aaaaaacagt 1380gtggatgatg atatgctttt gtgagcaagc aaaagcagaa acgtgaagcc gtgatacaaa 1440ttggtgaaca aaaaatgccc aaggcttctc atgtgtttat tctgaagagc tttaatatat 1500actctatgta gtttaataag cactgtacgt agaaggcctt aggtgttgca tgtctatgct 1560tgaggaactt ttccaaatgt gtgtgtctgc atgtgtgttt gtacatagaa gtcatagatg 1620cagaagtggt tctgctggta agatttgatt cctgttggaa tgtttaaatt acactaagtg 1680tactacttta tataatcaat gaaattgcta gacatgtttt agcaggactt ttctaggaaa 1740gacttatgta taattgcttt ttaaaatgca gtgctttact ttaaactaag gggaactttg 1800cggaggtgaa aacctttgct gggttttctg ttcaataaag ttttactatg aatgaccctg 1860 138 2074 DNA Homo sapiens 138gaattcggca cgaggcgcgg cggctgcgac cgggacggcc cattttccgc cagctcgccg 60ctcgctatgg cgtcgctcac cgtgaaggcc taccttctgg gcaaggagga cgcggcgcgc 120gagattcgcc gcttcagctt ctgctgcagc cccgagcctg aggcggaagc cgaggctgcg 180gcgggtccgg gaccctgcga gcggctgctg agccgggtgg ccgccctgtt ccccgcgctg 240cggcctggcg gcttccaggc gcactaccgc gatgaggacg gggacttggt tgccttttcc 300agtgacgagg aattgacaat ggccatgtcc tacgtgaagg atgacatctt ccgaatctac 360attaaagaga aaaaagagtg ccggcgggac caccgcccac cgtgtgctca ggaggcgccc 420cgcaacatgg tgcaccccaa tgtgatctgc gatggctgca atgggcctgt ggtaggaacc 480cgctacaagt gcagcgtctg cccagactac gacttgtgta gcgtctgcga gggaaagggc 540ttgcaccggg ggcacaccaa gctcgcattc cccagcccct tcgggcacct gtctgagggc 600ttctcgcaca gccgctggct ccggaaggtg aaacacggac acttcgggtg gccaggatgg 660gaaatgggtc caccaggaaa ctggagccca cgtcctcctc gtgcagggga ggcccgccct 720ggccccacgg cagaatcagc ttctggtcca tcggaggatc cgagtgtgaa tttcctgaag 780aacgttgggg agagtgtggc agctgccctt agccctctgg gcattgaagt tgatatcgat 840gtggagcacg gagggaaaag aagccgcctg acccccgtct ctccagagag ttccagcaca 900gaggagaaga gcagctcaca gccaagcagc tgctgctctg accccagcaa gccgggtggg 960aatgttgagg gcgccacgca gtctctggcg gagcagatga ggaagatcgc cttggagtcc 1020gaggggcgcc ctgaggaaca gatggagtcg gataactgtt caggaggaga tgatgactgg 1080acccatctgt cttcaaaaga agtggacccg tctacaggtg aactccagtc cctacagatg 1140ccagaatccg aagggccaag ctctctggac ccctcccagg agggacccac agggctgaag 1200gaagctgcct tgtacccaca tctcccgcca gaggctgacc cgcggctgat tgagtccctc 1260tcccagatgc tgtccatggg cttctctgat gaaggcggct ggctcaccag gctcctgcag 1320accaagaact atgacatcgg agcggctctg gacaccatcc agtattcaaa gcatcccccg 1380ccgttgtgac cacttttgcc cacctcttct gcgtgcccct cttctgtctc atagttgtgt 1440taagcttgcg tagaattgca ggtctctgta cgggccagtt tctctgcctt cttccaggat 1500caggggttag ggtgcaagaa gccatttagg gcagcaaaac aagtgacatg aagggagggt 1560ccctgtgtgt gtgtgtgctg atgtttcctg ggtgccctgg ctccttgcag cagggctggg 1620cctgcgagac ccaaggctca ctgcagcgcg ctcctgaccc ctccctgcag gggctacgtt 1680agcagcccag cacatagctt gcctaatggc tttcactttc tcttttgttt taaatgactc 1740ataggtccct gacatttagt tgattatttt ctgctacaga cctggtacac tctgatttta 1800gataaagtaa gcctaggtgt tgtcagcagg caggctgggg aggccagtgt tgtgggcttc 1860ctgctgggac tgagaaggct cacgaagggc atccgcaatg ttggtttcac tgagagctgc 1920ctcctggtct cttcaccact gtagttctct catttccaaa ccatcagctg cttttaaaat 1980aagatctctt tgtagccatc ctgttaaatt tgtaaacaat ctaattaaat ggcatcagca 2040ctttaaccaa taaaaaaaaa aaaaaaaaaa aaaa 2074 139 3500 DNA Homo sapiens 139ttgtgaaggg cgcgggtggg gggcgctgcc ggcctcgtgg gtacgttcgt gccgcgtctg 60tcccagagct ggggccgcag gagcggaggc aagaggggca ctatggcaga caaagttagg 120aggcagaggc cgaggaggcg agtctgttgg gccttggtgg ctgtgctctt ggcagacctg 180ttggcactga gtgatacact ggcagtgatg tctgtggacc tgggcagtga gtccatgaag 240gtggccattg tcaaacctgg agtgcccatg gaaattgtct tgaataagga atctcggagg 300aaaacaccgg tgatcgtgac cctgaaagaa aatgaaagat tctttggaga cagtgcagca 360agcatggcga ttaagaatcc aaaggctacg ctacgttact tccagcacct cctggggaag 420caggcagata acccccatgt agctctttac caggcccgct tcccggagca cgagctgact 480ttcgacccac agaggcagac tgtgcacttt cagatcagct cgcagctgca gttctcacct 540gaggaagtgt tgggcatggt tctcaattat tctcgttctc tagctgaaga ttttgcagag 600cagcccatca aggatgcagt gatcaccgtg ccagtcttct tcaaccaggc cgagcgccga 660gctgtgctgc aggctgctcg tatggctggc ctcaaagtgc tgcagctcat caatgacaac 720accgccactg ccctcagcta tggtgtcttc cgccggaaag atattaacac cactgcccag 780aatatcatgt tctatgacat gggctcaggc agcaccgtat gcaccattgt gacctaccag 840atggtgaaga ctaaggaagc tgggatgcag ccacagctgc agatccgggg agtaggattt 900gaccgtaccc tggggggcct ggagatggag ctccggcttc gagaacgcct ggctgggctt 960ttcaatgagc agcgcaaggg tcagagagca aaggatgtgc gggagaaccc gcgtgccatg 1020gccaagctgc tgcgtgaggc taatcggctc aaaaccgtcc tcagtgccaa cgctgaccac 1080atggcacaga ttgaaggcct gatggatgat gtggacttca aggcaaaagt gactcgtgtg 1140gaatttgagg agttgtgtgc agacttgttt gagcgggtgc ctgggcctgt acagcaggcc 1200ctccagagtg ccgaaatgag tctggatgag attgagcagg tgatcctggt gggtggggcc 1260actcgggtcc ccagagttca ggaggtgctg ctgaaggccg tgggcaagga ggagctgggg 1320aagaacatca atgcagatga agcagccgcc atgggggcag tgtaccaggc agctgcgctc 1380agcaaagcct ttaaagtgaa gccatttgtc gtccgagatg cagtggtcta ccccatcctg 1440gtggagttca cgagggaggt ggaggaggag cctgggattc acagcctgaa gcacaataaa 1500cgggtactct tctctcggat ggggccctac cctcaacgca aagtcatcac ctttaaccgc 1560tacagccatg atttcaactt ccacatcaac tacggcgacc tgggcttcct ggggcctgaa 1620gatcttcggg tatttggctc ccagaatctg accacagtga agctaaaagg ggtgggtgac 1680agcttcaaga agtatcctga ctacgagtcc aagggcatca aggctcactt caacctggat 1740gagagtggcg tgctcagtct agacagggtg gagtctgtat ttgagacact ggtagaggac 1800agcgcagaag aggaatctac tctcaccaaa cttggcaaca ccatttccag cctgtttgga 1860ggcggtacca caccagatgc caaggagaat ggtactgata ctgtccagga ggaagaggag 1920agccctgcag aggggagcaa ggacgagcct ggggagcagg tggagctcaa ggaggaagct 1980gaggccccag tggaggatgg ctctcagccc ccaccccctg aacctaaggg agatgcaacc 2040cctgagggag aaaaggccac agaaaaagaa aatggggaca agtctgaggc ccagaaacca 2100agtgagaagg cagaggcagg gcctgagggc gtcgctccag ccccagaggg agagaagaag 2160cagaagcccg ccaggaagcg gcgaatggta gaggagatcg gggtggagct ggttgttctg 2220gacctgcctg acttgccaga ggataagctg gctcagtcgg tgcagaaact tcaggacttg 2280acactccgag acctggagaa gcaggaacgg gaaaaagctg ccaacagctt ggaagcgttc 2340atatttgaga cccaggacaa gctgtaccag cccgagtacc aggaagtgtc cacagaggag 2400cagcgtgagg agatctctgg gaagctcagc gccgcatcca cctggctgga ggatgagggt 2460gttggagcca ccacagtgat gttgaaggag aagctggctg agctgaggaa gctgtgccaa 2520gggctgtttt ttcgggtaga ggagcgcaag aagtggcccg aacggctgtc tgccctcgat 2580aatctcctca accattccag catgttcctc aagggggccc ggctcatccc agagatggac 2640cagatcttca ctgaggtgga gatgacaacg ttagagaaag tcatcaatga gacctgggcc 2700tggaagaatg caactctggc cgagcaggct aagctgcccg ccacagagaa gcctgtgttg 2760ctctcaaaag acattgaagc taagatgatg gccctggacc gagaggtgca gtatctgctc 2820aataaggcca agtttaccaa gccccggccc cggcctaagg acaagaatgg gacccgggca 2880gagccacccc tcaatgccag tgccagtgac cagggggaga aggtcatccc tccagcaggc 2940cagactgaag atgcagagcc catttcagaa cctgagaaag tagagactgg atccgagcca 3000ggagacactg agcctttgga gttaggaggt cctggagcag aacctgaaca gaaagaacaa 3060tcgacaggac agaagcggcc tttgaagaac gacgaactat aacccccacc tctgttttcc 3120ccattcatct ccaccccctt cccccaccac ttctatttat ttaacatcga gggttggggg 3180aggggttggt cctgccctcg gctggagttc ctttctcacc cctgtgattt ggaggtgtgg 3240agaaggggaa gggagggaca gctcactggt tccttctgca gtacctctgt ggttaaaaat 3300ggaaactgtt ctcctcccca gccccactcc ctgttcccta cccatatagg ccctaaattt 3360gggaaaaatc actattaatt tctgaatcct ttgcctgtgg gtaggaagag aatggctgcc 3420agtggctgat gggtcccggt gatgggaagg gtatcaggtt gctggggagt ttccactctt 3480ctctggtgat tgttccttcc 3500 140 5468 DNA Homo sapiens 140cccggggtca ctcctgctgg acctactccg accccctagg ccgggagtga aggcgggact 60tgtgcggtta ccagcggaaa tgcctcgggg tcagaagtcg caggagagat agacagctgc 120tgaaccaatg ggaccagcgg atggggcgga tgttatctac cattggtgaa cgttagaaac 180gaatagcagc catgaatcag ctgggggggc ggagcagtga cgtttattgc ggagggggcc 240gcttcgaatc ggcggcggcc agcttggtgg cctgggccaa tgaacggcct ccaacgagca 300gggccttcac caatcggcgg cctccacgac ggggctgggg gagggtatat aagccgagta 360ggcgacggtg aggtcgacgc cggccaagac agcacagaca gattgaccta ttggggtgtt 420tcgcgagtgt gagagggaag cgccgcggcc tgtatttcta gacctgccct tcgcctggtt 480cgtggcgcct tgtgaccccg ggcccctgcc gcctgcaagt cgaaattgcg ctgtgctcct 540gtgctacggc ctgtggctgg actgcctgct gctgcccaac tggctggcaa gatgaagctc 600tccctggtgg ccgcgatgct gctgctgctc agcgcggcgc gggccgagga ggaggacaag 660aaggaggacg tgggcacggt ggtcggcatc gacttgggga ccacctactc ctggtaagtg 720gggttgcgga tgagggggac ggggcgtggc gctggctggc gtgagaagtg cggtgctgat 780gtccctctgt cgggtttttg cagcgtcggc gtgttcaaga acggccgcgt ggagatcatc 840gccaacgatc agggcaaccg catcacgccg tcctatgtcg ccttcactcc tgaaggggaa 900cgtctgattg gcgatgccgc caagaaccag ctcacctcca accccgagaa cacggtcttt 960gacgccaagc ggctcatcgg ccgcacgtgg aatgacccgt ctgtgcagca ggacatcaag 1020ttcttgccgt tcaaggttcg accggttttc ctcatccagt tagagaacgg gtgggtggtg 1080ggagtattta gagttataag tctctggaaa agtgttgaga caacagttga aggttataga 1140catgatgtat gtaataactt taatactatt agtatgttac aaaacttaag acagttgctg 1200tcgtactgtc tacgatagtt taggaataaa agaccgatta aaactgaact ttgtaagaca 1260cctatactcc ctgaagtatt tctagtcaat ttgcagcccc aagggaccaa aataaaccaa 1320attgtgggga tggtagtggg tcttttaaac tttgagatgt cattgtatct gtgtctgaaa 1380acaataattc tttaaaatag gtggttgaaa agaaaactaa accatacatt caagttgata 1440ttggaggtgg gcaaacaaag acatttgctc ctgaagaaat ttctgccatg gttctcacta 1500aaatgaaaga aaccgctgag gcttatttgg gaaagaaggt aaatatttct agaacaatgt 1560taagtatttt ttgatcatta gtattctcgg ttggctgtta tgtatagaag ccttcgtgaa 1620gggtttcaaa aattttaatc agaatggtat tcatgcttgt cacggtttaa ttattgagtc 1680cctttactat aagccaaaca aaaatagact tttcatgtat tatttaatgc ttacattcca 1740ggaacaataa aattttatat gttgtattca tcaataattg gcttaaaaac taaagtgatg 1800gtttgactgt aatttttttt ttttgagatg gagtcttgct ctgttgccca ggctggactg 1860cagtggcacg atctcagctc actgcaacct ctgcctcccg ggttaagcag ctctcctgcc 1920tcagcctcca agtaatggaa cgacaggcac accaccacag ctggctaatt tttttttttt 1980tttttaattt tcagtagaga cagggtttct ccacattgcc aggctggtct tgaaatcctg 2040ccctcaggtt gatcctcctg cctagcctcc caaagtgctg gattataggc agaagccacc 2100gcctggccag actgtaattt aaataagggt taaactatgt gacaatacac ttaattatct 2160ttatcctttt aggttaccca tgcagttgtt actgtaccag cctattttaa tgatgcccaa 2220cgccaagcaa ccaaagacgc tggaactatt gctggcctaa atgttatgag gatcatcaac 2280gagccgtaag tatgaaattc agggatacgg catatttgcc aaatagtgga aatgtgaagt 2340actgacaaaa cttttccctt tttcaatcta atagtacggc agctgctatt gcttatggcc 2400tggataagag ggagggggag aagaacatcc tggtgtttga cctgggtggc ggaaccttcg 2460atgtgtctct tctcaccatt gacaatggtg tcttcgaagt tgtggccact aatggagata 2520ctcatctggg tggagaagac tttgaccagc gtgtcatgga acacttcatc aaactgtaca 2580aaaagaagac gggcaaagat gtcaggaagg acaatagagc tgtgcagaaa ctccggcgcg 2640aggtagaaaa ggccaaggcc ctgtcttctc agcatcaagc aagaattgaa attgagtcct 2700tctatgaagg agaagacttt tctgagaccc tgactcgggc caaatttgaa gagctcaaca 2760tggtatgttc cttgttttct gctttgctaa tgagatctcc ttagactctg aattcaggac 2820attgcatcta gatacttaga taacagacat cacagtaacc atgtcttttt tctaggatct 2880gttccggtct actatgaagc ccgtccagaa agtgttggaa gattctgatt tgaagaagtc 2940tgatattgat gaaattgttc ttgttggtgg ctcgactcga attccaaaga ttcagcaact 3000ggttaaagag ttcttcaatg gcaaggaacc atcccgtggc ataaacccag atgaagctgt 3060agcgtatggt gctgctgtcc aggctggtgt gctctctggt gatcaagata caggtaggtc 3120atcatcgcag catctttctt agtgattcag tagcttgatg gaagagctcg gtacccctat 3180tgctttagaa aataccagaa tatgagcaac aaggtcacac agctagtaaa gggtataagt 3240gaagacaaga ctggggtagt ctccaagatc attagcaact gtttaattca ctgcctttaa 3300aatgtgtgtg ttagaaccta accaaatgtt agagagataa actttacata gctcataggg 3360agaacttgaa ttaaaagtta aataacttat ccttacaggt gacctggtac tgcttcatgt 3420atgtcccctt acacttggta ttgaaactgt aggaggtgtc atgaccaaac tgattccaag 3480taatacagtg gtgcctacca agaactctca gatcttttct acagcttctg ataatcaacc 3540aactgttaca atcaaggtct atgaaggtaa ttaccttaag tttggttaat atcatggctt 3600tttttttgag atgaagtctt gctctgttgc ccaggctgga ctgcagtggc acgatctcgg 3660ctcactgcaa attctgtctc ccgggttcaa gtgattctcc tgcctcagcc tccagagtag 3720ctggattaca gcctgaccac cacacctggc taatttctgt atttttagta gaggatgggc 3780tttcaccatg tttcccaggc tggtctccaa ctcctgacct caggtcatct gcctgcctcc 3840accgtcccga aagtactggg attatagcgt gagccaccac gccagatcta tctatcatgg 3900catattttaa aagaacatga cttaatatgt cctattgaaa tggctaggga actaagtaac 3960tgctgttttc agatggaggt cttaatttga ataatgttga tattagatat ttagcattct 4020tttttttttt tttttaatgg agtcttgctc tgtcgcctag gctggggtgc agtggcatga 4080cttgcaacct ctgcctcccg aatagctggg attacaggtg cccaccatca cgcccggcta 4140agttttgtat ttttagtaga ggcgagtttc gccatgttgg ccaggctggt cttgaacccc 4200taacctcagt gatcccacgg tcaccgacct ggcctcccaa aagtactgta cccagccaat 4260gattagcatt ctcactaata atagcatctg agctggctcc tagagtacaa gaaaaaggag 4320ttcacagtac tttaaaatag ataaaattca gttgagttag taacctaact cattgttagt 4380actagttgct gctccttgta gaccaatatg aaattacttt tagctcgata aaaccaaaag 4440tgtcacttta tgcttcagac tgaaatgcgg ggatctagat gtgctaatgc ttgtcagtaa 4500caactaacaa gtttttctgt atgtaacttc taggtgaaag acccctgaca aaagacaatc 4560atcttctggg tacatttgat ctgactggaa ttcctcctgc tcctcgtggg gtcccacaga 4620ttgaagtcac ctttgagata gatgtgaatg gtattcttcg agtgacagct gaagacaagg 4680gtacagggaa caaaaataag atcacaatca ccaatgacca gaatcgcctg acacctgaag 4740aaatcgaaag gatggttaat gatgctgaga agtttgctga ggaagacaaa aagctgaagg 4800agcgcattga tactagaaat gagttggaaa gctatgccta ttctctaaag aatcagattg 4860gagataaaga aaagctggga ggtaaacttt cctctgaaga taaggagacc atggaaaaag 4920ctgtagaaga aaagattgaa tggctggaaa gccaccaaga tgctgacatt gaagacttca 4980aagctaagaa gaaggaactg gaagaaattg ttcaaccaat tatcagcaaa ctctatggaa 5040gtgcaggccc tcccccaact ggtgaagagg atacagcaga aaaagatgag ttgtagacac 5100tgatctgcta gtgctgtaat attgtaaata ctggactcag gaacttttgt taggaaaaaa 5160ttgaaagaac ttaagtctcg aatgtaattg gaatcttcac ctcagagtgg agttgaaact 5220gctatagcct aagcggctgt ttactgcttt tcattagcag ttgctcacat gtctttgggt 5280gggggggaga agaagaattg gccatcttaa aaagcgggta aaaaacctgg gttagggtgt 5340gtgttcacct tcaaaatgtt ctatttaaca actgggtcat gtgcatctgg tgtaggaggt 5400tttttctacc ataagtgaca ccaataaatg tttgttattt acactggtct aatgtttgtg 5460agaagctt 5468 141 1990 DNA Homo sapiens 141gaattccggg ggtattggca gctgaggagt ggaggctggg cagctccgac tccctgacgc 60cagcgcgacc agatcaatcc aggctccagg agaaagcagg cgggcgggcg gagaaaggag 120aggccgagcg gctcaacccg ggccgaggct cggggagcgg agagtggcgc accgcccggc 180cgtccggacc cgggccgcga gaccccgctc gcccggccac tcgtgctccc gcacggacgg 240gcgcgccgcc aacccggtgc tgactgggtt acttttttaa acactaggaa tggtaatttc 300tactcttctg gacttcaaac taagaagtta aagagacttc tctgtaaata aacaaatctc 360ttctgctgtc cttttgcatt tggagacagc tttatttcac catatccaag gagtataact 420agtgctgtca ttatgaatgt gacaagttta ttttccttta caagtccagc tgtgaagaga 480cttcttgggt ggaaacaggg cgatgaagaa gaaaaatggg cagagaaagc tgttgatgct 540ttggtgaaaa aactgaagaa aaagaaaggt gccatggagg aactggaaaa ggccttgagc 600tgcccagggc aaccgagtaa ctgtgtcacc attccccgct ctctggatgg caggctgcaa 660gtctcccacc ggaagggact gcctcatgtc atttactgcc gtgtgtggcg ctggcccgat 720cttcagagcc accatgaact aaaaccactg gaatgctgtg agtttccttt tggttccaag 780cagaaggagg tctgcatcaa tccctaccac tataagagag tagaaagccc tgtacttcct 840cctgtgctgg ttccaagaca cagcgaatat aatcctcagc acagcctctt agctcagttc 900cgtaacttag gacaaaatga gcctcacatg ccactcaacg ccacttttcc agattctttc 960cagcaaccca acagccaccc gtttcctcac tctcccaata gcagttaccc aaactctcct 1020gggagcagca gcagcaccta ccctcactct cccaccagct cagacccagg aagccctttc 1080cagatgccag ctgatacgcc cccacctgct tacctgcctc ctgaagaccc catgacccag 1140gatggctctc agccgatgga cacaaacatg atggcgcctc ccctgccctc agaaatcaac 1200agaggagatg ttcaggcggt tgcttatgag gaaccaaaac actggtgctc tattgtctac 1260tatgagctca acaatcgtgt gggtgaagcg ttccatgcct cctccacaag tgtgttggtg 1320gatggtttca ctgatccttc caacaataag aaccgtttct gccttgggct gctctccaat 1380gttaaccgga attccactat tgaaaacacc aggcggcata ttggaaaagg agttcatctt 1440tattatgttg gaggggaggt gtatgccgaa tgccttagtg acagtagcat ctttgtgcaa 1500agtcggaact gcaactacca tcatggattt catcctacta ctgtttgcaa gatccctagt 1560gggtgtagtc tgaaaatttt taacaaccaa gaatttgctc agttattggc acagtctgtg 1620aaccatggat ttgagacagt ctatgagctt acaaaaatgt gtactatacg tatgagcttt 1680gtgaagggct ggggagcaga ataccaccgc caggatgtta ctagcacccc ctgctggatt 1740gagatacatc tgcacggccc cctccagtgg ctggataaag ttcttactca aatgggttca 1800cctcataatc ctatttcatc tgtatcttaa atggccccag catctgcctc tggaaaacta 1860ttgagccttg catgtacttg aaggatggat gagtcagaca cgattgagaa ctgacaaagg 1920agccttgata atacttgacc tctgtgacca actgttggat tcagaaattt aaacaaaaaa 1980aaaaaaaaaa 1990 142 576 DNA Homo sapiens 142tgggggagat tgggactggg gaaatggccc ttgagtgaag gaaagggaga taaagctgag 60gaagaggcct caggactcag cacagggtgg caacactacc attcactgtc cctgtgccat 120ttcttcagac tctgggccgc caccaccacc agatggccaa gagcagataa ccttttgtcc 180acagccaggt agagatgggc aacttacatg gccttgagaa gaggtataga aaaaggagtg 240cttttgaggg ctaccccctg ttgtgaccat tcctgaagtg cagagaccac accagcaaaa 300catgcccagt cttagtagtg gggacgaaga attgatgagt ggatccagtc agctccggca 360gacaggccac agggttgcca ggtttgatga gccaaccagg tgagcacaca gcttcggagc 420actgccctga atcctgtctt ctccctcagg actgcccttt cctggccaca ccaagtttgg 480cacctctcca gaaagttggc agggagcaag tggcagacag cacccctctc tccctagcct 540attaacacac agagccgcca atggcagggc agagcg 576 143 1932 DNA Homo sapiens 143gcggccgcac caattttttt ttttttattt tttttttttt tttttttttt ttcaaatatt 60cagggaactt tatttttaaa gaataaatca agtaagacac agctttcgtt tacctaaaca 120tgcataatcc aacctgaata taaactgcac ttaattggtg aattacacat gaaatacaaa 180gggaatgcaa ttttacatat gtaaaatgat tgctagctat agcaatttaa cagtcaaatt 240tatcagaaca ttgtacatta aaaaacacaa acaacaactt aaagccaaat atctatagta 300aaccaaggaa aattctgata tggaatggtt tgactaaaag caaagaataa ggcacctgct 360atgaatttag cacaaccata aaacagaatt agttaaccaa gacacttgtt tcaaaaaggg 420aaacaagtac agagactgat taactgggtg agaaaggcaa gtaacaattt agttaaaaac 480ctgctggccc aaggtcagtt gattcattcc ttattccaga atagttaagt tcctgaaagt 540ccttaaccac tctgctccct tactgttctc catgtttgag ggtatcagaa gccccctgtg 600aggttcacgc tgtgtataga ctaggtagca gatttccctt ctgttcctct taaaacagct 660tattttaaaa gaaatatcct gaggcaatta acaaagcaaa cacaagcagc tttctttcca 720acgcattaat acatagacac tgctcaggtt ttttttcacc aagttatggc taagtataca 780aatagccaat acttgcagtt ttcaacagta ctagaaaacc caaaacctgc cctatgaccc 840tcacccttac cattagtaaa acgtaaattt gatcaatcat aacctataaa gtcatataac 900aaagggaaga ctaaagactg atcattatca gtaaatccat tcaattccag atgccacttt 960aggctgatgt gtctagtacc ctaatgattg aaaaatcatt aatctagaaa aagcatttgc 1020aaactaagga taacttcgca gttgatgtgc ctttttttgc tattaaaagt gctatttaac 1080atgctaaaat gtcttatggc acattggact caacagcatg ttctgatgag gcatccattt 1140ttagcagtat ttttccctag aattttgttt ggcatagtaa acccctttga tatattaaaa 1200tagttctggt gaaataaatg taacataaac aaaccttccc tgactgactt cactccacca 1260cggtagcttt tagtgaaacc acagtaactg attaagtcag aaaacgatca agtttttttt 1320ttatggcatc ttgggttact atactcactc atgcaaaatc caaggtagtg taatggaaac 1380aatattggta aaatagatgt tgtggctata agcatctccc tttatattag acatttagaa 1440gcttttaaaa ctttttagat gctaaaggtt gtggcaaaac taggctgtgt agttgttcca 1500tttataagca ccttattaca ggacagttac atgaacctat aagggagtgt gctttcagtt 1560caaaagagta ataaagtgcc tagctatata aaaaccacaa gacttcaaat tgtaatttaa 1620gctaactgca gttatacatt tgggttaaca aaatctagac cctgtctatg cagagttaga 1680ctaattgttc atactgtttt aataaccaca taaaaaaact tactcttaat tgactgaata 1740agtagggtcc actactgtat cttaacaatc aaattttatt gctttattca tgtggtgttt 1800tttgcaaggc actgtggtat ggactagaaa acttggaatg actcatgaag aaaccttgga 1860atgacacatg aagcatgata ggaaagtcat tctgaggcag gatgctttac tgaattgcct 1920cgtgccgaat tc 1932 144 1846 DNA Homo sapiens 144gcagtgcggc ggtcacaggc tgagtgctgc ggcgcgatcc ttgcttccct gagcgttggc 60ccgggaggaa agaagatggt gctggatctg gatttgtttc gggtggataa aggaggggac 120ccagccctca tccgagagac gcaggagaag cgcttcaagg acccgggact agtggaccag 180ctggtgaagg cagacagcga gtggcgacga tgtagatttc gggcagacaa cttgagcaag 240ctgaagaacc tatgcagcaa gacaatcgga gagaaaatga agaaaaaaga gccagtggga 300gatgatgagt ctgtcccaga gaatgtgctg agtttcgatg accttactgc agacgcttta 360gctaacctga aagtctcaca aatcaaaaaa gtccgactcc tcattgatga agccatcctg 420aagtgtgacg cggagcggat aaagttggaa gcagagcggt ttgagaacct ccgagagatt 480gggaaccttc tgcacccttc tgtacccatc agtaacgatg aggatgtgga caacaaagta 540gagaggattt ggggcgattg tacagtcagg aagaagtact ctcatgtgga cctggtggtg 600atggtagatg gctttgaagg cgaaaagggg gccgtggtgg ctgggagtcg agggtacttc 660ttgaaggggg tcctggtgtt cctggaacag gctctcatcc agtatgccct tcgcaccttg 720ggaagtcggg gctacattcc catttatacc ccctttttca tgaggaagga ggtcatgcag 780gaggtggcac agctcagcca gtttgatgaa gaactttata aggtgattgg caaaggcagt 840gaaaagtctg atgacaactc ctatgatgag aagtacctga ttgccacctc agagcagccc 900attgctgccc tgcaccggga tgagtggctc cggccggagg acctgcccat caagtatgct 960ggcctgtcta cctgcttccg tcaggaggtg ggctcccatg gccgtgacac ccgtggcatc 1020ttccgagtcc atcagtttga gaagattgaa cagtttgtgt actcatcacc ccatgacaac 1080aagtcatggg agatgtttga agagatgatt accaccgcag aggagttcta ccagtccctg 1140gggattcctt accacattgt gaatattgtc tcaggttctt tgaatcatgc tgccagtaag 1200aagcttgacc tggaggcctg gtttccgggc tcaggagcct tccgtgagtt ggtctcctgt 1260tctaattgca cggattacca ggctcgccgg cttcgaatcc gatatgggca aaccaagaag 1320atgatggaca aggtggagtt tgtccatatg ctcaatgcta ccatgtgcgc cactacccgt 1380accatctgcg ccatcctgga gaactaccag acagagaagg gcatcactgt gcctgagaaa 1440ttgaaggagt tcatgccgcc aggactgcaa gaactgatcc cctttgtgaa gcctgcgccc 1500attgagcagg agccatcaaa gaagcagaag aagcaacatg agggcagcaa aaagaaagca 1560gcagcaagag acgtcaccct agaaaacagg ctgcagaaca tggaggtcac cgatgcttga 1620acattcctgc ctccctattt gccaggcttt catttctgtc tgctgagatc tcagagcctg 1680cccaacagca gggaagccaa gcacccattc atccccctgc ccccatctga ctgcgtagct 1740gagaggggaa cagtgccatg taccacacag atgttcctgt ctcctcgcat gggcataggg 1800acccatcatt gatgactgat gaaaccatgt aataaagcat ctctgg 1846 145 2131 DNA Homo sapiens 145ctctttataa tttagtttcc atagaagtta tatgtgcatt taaaaaaatt caatgctgga 60gcgaccgtgt ctggggagcc gagccccgct tctcgctgcg gtgagcccgg actggggcac 120gcactgcgca gactccccgc tgcagtgggc ggagtcccac aggccccgcc cctcctccca 180ccctcgttca gcctgtccag acagaagctg gggcccagcg gaggtagcag cagacgcctg 240agagcgaggc cgaggccctc agggtttgga gaccctgaca cacccacctt ctcacctggg 300ctctgcgtat cccccagcct tgagggaaga tgaagcctaa actgatgtac caggagctga 360aggtgcctgc agaggagccc gccaatgagc tgcccatgaa tgagattgag gcgtggaagg 420ctgcggaaaa gaaagcccgc tgggtcctgc tggtcctcat tctggcggtt gtgggcttcg 480gagcctgatg actcagctgt ttctatggga atacggcgac ttgcatctct ttgggcccaa 540ccagcgccca gccccctgct atgacccttg cgaagcagtg ctggtggaaa gcattcctga 600gggcctggac ttccccaatg cctccacggg gaacccttcc accagccagg cctggctggg 660cctgctcgcc ggtgcgcaca gcagcctgga catcgcctcc ttctactgga ccctcaccaa 720caatgacacc cacacgcagg agccctctgc ccagcagggt gaggaggtcc tccggcagct 780gcagaccctg gcaccaaagg gcgtgaacgt ccgcatcgct gtgagcaagc ccagcgggcc 840ccagccacag gcggacctgc aggctctgct gcagagcggt gcccaggtcc gcatggtgga 900catgcagaag ctgacccatg gcgtcctgca taccaagttc tgggtggtgg accagaccca 960cttctacctg ggcagtgcca acatggactg gcgttcactg acccaggtca aggagctggg 1020cgtggtcatg tacaactgca gctgcctggc tcgagacctg accaagatct ttgaggccta 1080ctggttcctg ggccaggcag gcagctccat cccatcaact tggccccggt tctatgacac 1140ccgctacaac caagagacac caatggagat ctgcctcaat ggaacccctg ctctggccta 1200cctggcgagt gcgcccccac ccctgtgtcc aagtggccgc actccagacc tgaaggctct 1260actcaacgtg gtggacaatg cccggagttt catctacgtc gctgtcatga actacctgcc 1320cactctggag ttctcccacc ctcacaggtt ctggcctgcc attgacgatg ggctgcggcg 1380ggccacctac gagcgtggcg tcaaggtgcg cctgctcatc agctgctggg gacactcgga 1440gccatccatg cgggccttcc tgctctctct ggctgccctg cgtgacaacc atacccactc 1500tgacatccag gtgaaactct ttgtggtccc cgcggatgag gcccaggctc gaatcccata 1560tgcccgtgtc aaccacaaca agtacatggt gactgaacgc gccacctaca tcggaacctc 1620caactggtct ggcaactact tcacggagac ggcgggcacc tcgctgctgg tgacgcagaa 1680tgggaggggc ggcctgcgga gccagctgga ggccattttc ctgagggact gggactcccc 1740ttacattcat gaccttgaca cctcagctga cagcgtgggc aacgcctgcc gcctgctctg 1800aggcccgatc cagtgggcag gccaaggcct gctgggcccc cgcggaccca ggtgctctgg 1860gtcacggtcc ctgtccccgc acccccgctt ctgtctgccc cattgtggct cctcaggctc 1920tctcccctgc tctcccacct ctacctccac ccccaccggc ctgacgctgt ggccccggga 1980cccagcagag ctgggggagg gatcagcccc caaagaaatg ggggtgcatg ctggcctgcc 2040ccctggccca cccccacttt ccagggcaaa aagggcccag ggttataata agtaaataac 2100ttgtctgtaa aaaaaaaaaa aaaaaaaaaa a 2131 146 1044 DNA Homo sapiens 146ttaattaaag atcttttttt tttttttttt tgccagtgcc aggataaaaa gcaaaatttt 60aaattggaaa atgtctagca ctttacacag tggaatgaaa gaatacgaaa ttcaaaaaca 120ttattaaaag tccatatgcc gcagcagcac gcgccatgat gagagctccc cttccgaggc 180gcttctggag cagcttcctc aacctgtccg ggagacgggc tcagaagagc agggccccca 240tgctgccaac ctcgctttgc tccttaacga agatctcaaa gtactggtag atgattgtga 300ctgcgagcag gatcccggtt ccagacccaa tggcgcctag gaagtcagcc aggaccgaga 360gggccccgat gcacagccca ccaaaggccg cggctgtggg gatgtaccgg ttgagttcat 420ggaccatggg aggtctctcg gtggcctctc atcaccatct gctgctcctt cagctgcttt 480gcaacatctt tggcagagga acctgagacc tcaatccacg ttttggagaa gaatgcacag 540gagcccagca tgaacactat gtatacaact gcatggaccg ggtcttctaa cacggagcca 600aaagattctg gaggggacag gtaatagcaa aggccaccaa ctggataagc acgtgctgac 660cagcaagttg ccactgaagc gagctgagag catttgggag atgacataaa ggttggacac 720cagggcagac tgcaggatga tggggatgtt ggacgtatag aagagcttga tgggataggt 780gttgtactgg ccacggtagc gggccgactt gattggcagg tccactcgga agccctggaa 840atagatgacc actgcaaaga caaagatggt ggcgatgaga ttcatgaggt tgggaagatt 900ctggcggtag aacgcctccc gaagggctcg gaccttgtct gtgcgtgtgg ccagcagatg 960gaaaagtgcg atgatagcac cttcaaattc cattcctcgg ccagtgttga cagtagtggg 1020gctgaatgcc ctcgtgccga attc 1044 147 526 DNA Homo sapiens misc_feature (1)...(526) n = A,T,C or G 147aacnaagatc tttttttttt tttttttttt gcttgatttt attttattaa aaaagactgg 60aactcagtcc nttnttccta ttaagtccat tttcccaaga gatgtcactg tttgagataa 120taacttaaat attcttgatg tggaggtagt ctctctcttc ctagtgggat gtcttcttag 180ctcctttccc aaacttggca tcaagaccaa gacccaggaa cacaagcaca gtgcccaccc 240actgcatggg gctgatggga ttggcgaaga ggatcacaga ggccaaaatt gtgaagaact 300ttcgagttgt agtgatgatg gagcaggtca ggggaccaaa atacacaacc gtcataaaga 360tgaagctctg acccagggca ctggtcagcc caaagagcag ggatgttata gatgatggca 420gggtaccttt cagcaaagct caagaactcc cagagctccc cagtgaacag gattcccatt 480cccagcagca aatgtcgcca aaaggtttga tgttcagcat catggt 526 148 1923 DNA Homo sapiens 148gccgggcagg aggaaggagc ctccctcagg gtttcgggaa ccagatctct caccaggaaa 60gactgataca gaacgatcga tacagaaacc acgctgccgc caccacacca tcaccatcga 120cagaacagtc cttaatccag aaacctgaaa tgaaggaaga ggagactctg cgcagagcac 180tttgggtccg gagggcgaga ctccggcgga agcattcccg ggcgggtgac ccagcacggt 240ccctcttgga attggattcg ccattttatt tttcttgctg ctaaatcacc gagcccggaa 300gattagagag ttttatttct gggattcctg tagacacacc cacccacata catacattta 360tatatatata tattatatat atataaaaat aaatatctct attttatata tataaaatat 420atatattctt tttttaaatt aacagtgcta atgttattgg tgtcttcact ggatgtattt 480gactgctgtg gacttgagtt gggaggggaa tgttcccact cagatcctga cagggaagag 540gaggagatga gagactctgg catgatcttt tttttgtccc acttggtggg gccagggtcc 600tctcccctgc ccaggaatgt gcaaggccag ggcatggggg caaatatgac ccagttttgg 660gaacaccgac aaacccagcc ctggcgctga gcctctctac cccaggtcag acggacagaa 720agacagatca caggtacagg gatgaggaca ccggctctga ccaggagttt ggggagcttc 780aggacattgc tgtgctttgg ggattccctc cacatgctgc acgcgcatct cgcccccagg 840ggcactgcct ggaagattca ggagcctggg cggccttcgc ttactctcac ctgcttctga 900gttgcccagg aggccactgg cagatgtccc ggcgaagaga agagacacat tgttggaaga 960agcagcccat gacagctccc cttcctggga ctcgccctca tcctcttcct gctccccttc 1020ctggggtgca gcctaaaagg acctatgtcc tcacaccatt gaaaccacta gttctgtccc 1080cccaggagac ctggttgtgt gtgtgtgagt ggttgacctt cctccatccc ctggtccttc 1140ccttcccttc ccgaggcaca gagagacagg gcaggatcca cgtgcccatt gtggaggcag 1200agaaaagaga aagtgtttta tatacggtac ttatttaata tcccttttta attagaaatt 1260aaaacagtta atttaattaa agagtagggt tttttttcag tattcttggt taatatttaa 1320tttcaactat ttatgagatg tatcttttgc tctctcttgc tctcttattt gtaccggttt 1380ttgtatataa aattcatgtt tccaatctct ctctccctga tcggtgacag tcactagctt 1440atcttgaaca gatatttaat tttgctaaca ctcagctctg ccctccccga tcccctggct 1500ccccagcaca cattcctttg aaataaggtt tcaatataca tctacatact atatatatat 1560ttggcaactt gtatttgtgt gtatatatat atatatatgt ttatgtatat atgtgattct 1620gataaaatag acattgctat tctgtttttt atatgtaaaa acaaaacaag aaaaaataga 1680gaattctaca tactaaatct ctctcctttt ttaattttaa tatttgttat catttattta 1740ttggtgctac tgtttatccg taataattgt ggggaaaaga tattaacatc acgtctttgt 1800ctctagtgca gtttttcgag atattccgta gtacatattt atttttaaac aacgacaaag 1860aaatacagat atatcttaaa aaaaaaaaaa gcattttgta ttaaagaatt taattctgat 1920ctc 1923 149 157 DNA Homo sapiens misc_feature (1)...(157) n = A,T,C or G 149tttttttcnt gatcaaangt actcttttat tcttaaataa aaatcttaat tngctttgac 60ctccaaaggc tctaatccca ntctccaaat tcnnntnaag ggatgntctn ttcatgtggg 120gccggtttaa acagaggctg cctcaccaga gcagcct 157 150 1220 DNA Homo sapiens 150ctcgaggcca agaattcggc acgaggcaat cagcatacag tacagactga aaatagattt 60catggatcta gcaagcactg caggactgtc actcaacgaa gaggaaatat ggttactaca 120tacactgact gttcaggaca gtagttctta ttctattctc actaaatcca actggttgac 180tcttcctcat tatctttgat gctaaacaat tttctgtgaa ctattttgac aagtgcatga 240tttcacttta aacaatttga tatagctatt aagtatattt aagggttttt ttttttgaca 300aattcaacat tcaacgagta gacaaaatgc taattatttc cctgattagg aaagtttctt 360taaaaaacac gtaattttgc ctagtgcttt ttctctacct gcccttgggc tcactaatat 420caccagtatt attaccaaga aaatattgag tttacctgat taaactttaa aagttaattg 480tagatttaaa ttgtgtgaac ctaatgattt ttgcagtgaa acctttacta attcaaagtt 540gcatgttcta tgacatctgt gacttgcgtt gcagagtgta catgaaactg tataattgag 600tcattcagta aaggagaaca gtatcttggt taattgctac tgaaaggttg agaaaggaat 660ggtttgatat ttaccacagc gctgtgcctt tctacagtag aactggggta aaggaaatgg 720ttttattgcc catagtcatt taggctggaa aaaagttgaa aacttaacga aatattgcca 780agagattgtt atgtgtttgg ttccagccta aaaatgattt tgtagtgttg aaatcatagc 840tacttacata gctttttcat atttctttct tagttgttgg cactcttagg tcttagtatg 900gatttatgtg tttgtgtgtg tgtagtttat cctctctctc atctttatct agagattgac 960tgatacctca ttctgtttgt aaaaccagcc agtaatttct gtgcaacctt actatgtgca 1020atatttttaa atcctgagaa atgtgtgctt ttgttttcgg atagacttat ttctttagtt 1080ctgcactttt ccacattata ctccatatga gtattaatcc tatggataca tattaaaaca 1140agtgtctcat acaacattgt atgtgagaga aatataaata tttacaacct gaaaaaaaaa 1200aaaaaaaaaa tggcggccgc 1220 151 546 DNA Homo sapiens misc_feature (1)...(546) n = A,T,C or G 151cttttttttt tttttaaaaa acaaactgca aaatggtatt tatttacatt aaaacatgaa 60ttgcctgtat tnacacaaat ataagaggaa caatctgtta tgcacaataa ctgtaatatt 120tagtacatgt tatacacagc agtatctgtt aagtcagtgg tttgagtgaa aacacagtac 180caaaacattc ctgatacaaa ataagttact cattcacata ttctaatcat acaagacact 240taatatttta aaagttacat acttcaaata acactggcta aatgtacaac taaagtttat 300taattttttt tatgaaaaga cttcagattg ttattcataa atgatccctt tcaggatgca 360ttatctttta aataaataaa ctaaattgac ttcaagacta tttataaata gcccactaaa 420atatgattga agacattcct tcattttatt aaaggtgtag ctatatacta gagaatatgc 480tcaactactg cctccaaatt ccaacactgt cattctaatt tgcaaatagg aattatttaa 540attcca 546 152 543 DNA Homo sapiens misc_feature (1)...(543) n = A,T,C or G 152tttttttttt tttcaaatct anatacttat tttacttcat cagttccaat cacntttctc 60atcatacatc caatgacaat atacatatct tcatgggtnc taccattttg canaggcatc 120atttactaat gcaattatcc aattgattta atgatnctag ctttattctg ggttattata 180ttccatatta tacaatgata ggatatttga agagacatat aattttgtaa gacaagactc 240attacatgat tgtattattt tctatgacat atttaaagag tttaataaca tgtataagta 300aaancaaatt taggagaaga gtcaagatat ttcatgtatt ccaaagaact gatnctagta 360ttgaggaagc taatagccta aaattatatc caaggcatgg ccacatnttt ttcccaaaat 420gtctgaatga tcagggcaac ttcttatggt tcccttaggc tgtcagtctt gnccttctct 480tctgggagct ntggggtaaa agtttggtct acagcagaag tgaaacatng gttgggctgg 540gtt 543 153 516 DNA Homo sapiens misc_feature (1)...(516) n = A,T,C or G 153tttttttttt gacngttttt aattgtgcct ttattcaact tagttcatta aaaatgtttt 60aaagatcntt taaataaagt gaccactnac atgggatata ggtcacccct cagcatgtta 120ttttttttct taaaaagcag tatttcttac aggaatctta ctgatcacac ggtagttaca 180ataatgtcag atatgatgta tacagtctaa acgagacagt ccagttaaga atatacataa 240tgtaaaaata cacatattaa aagttagcca agtggacaga cgcatgcggg ggtgggggga 300gcaggtgaca ggaactcctt taacaatcag tagagggccc agatgcaaag aatctggttt 360tccccgttac agtaaacagc tttcactaac gtatacaggt atttcataca catctaaaca 420cacaaggggt aagttgtgac ctgctacaca tagggtctaa agtggtgtaa ttgtgatttt 480cccctcgtgc cgaattcttg gcctcgaggg ccaaat 516 154 985 DNA Homo sapiens 154gaattcggca cgaggctgtt caggggatcc ttctgtttct cacggggtga aacatgtctt 60tagttcctca tgttaacacg aagccagagc ccacatgaac tgttggatgt cttccttaga 120aagggtaggc atggaaaatt ccacgaggct cattctcagt atctcattaa ctcattgaaa 180gattccagtt gtatttgtca cctggggtga caagaccaga caggctttcc caggcctggg 240tatccaggga ggctctgcag ccctgctgaa gggccctaac tagagttcta gagtttctga 300ttctgtttct cagtagtcct tttagaggct tgctatactt ggtctgcttc aaggaggtcg 360accttctaat gtatgaagaa tgggatgcat ttgatctcaa gaccaaagac agatgtcagt 420gggctgctct ggccctggtg tgcacggctg tggcagctgt tgatgccagt gtcctctaac 480tcatgctgtc cttgtgatta aacacctcta tctcccttgg gaataagcac atacaggctt 540aagctctaag atagataggt gtttgtcctt ttaccatcga gctacttccc ataataacca 600ctttgcatcc aacactcttc acccacctcc catacgcaag gggatgtgga tacttggccc 660aaagtaactg gtggtaggaa tcttagaaac aagaccactt atactgtctg tctgaggcag 720aagataacag cagcatctcg accagcctct gccttaaagg aaatctttat taatcacgta 780aggttcacag ataattcttt ttttaaaaaa acccaacctc ctagagaagc acaactgtca 840agagtcttgt acacacaact tcagctttgc atcacgagtc ttgtattcca agaaaatcaa 900agtggtacaa tttgtttgtt tacactatga tactttctaa ataaactctt tttttttaaa 960aaaaaaaaaa aaaaaaggcg gccgc 985 155 1280 DNA Homo sapiens 155ctcgaggcca agaattcggc acgagggaaa ggagaagatg aaaaagagga agaagacaga 60aaagaaacag gagatggaaa agagaatgaa gatggaaaag agaagggaga taaaaaagag 120gggaaagatg taaaagtcaa agaagatgaa aaagagagag aagatggaaa agaagatgaa 180ggtggaaatg aggaagaagc tggaaaagag aaagaagatt taaaagaaga ggaagaagga 240aaagaggaag atgagatcaa agaagatgat ggaaaaaaag aggagccaca gagtattgtt 300taaaactgcc ctatgtagtt tcataatttg gtaacatgta ccttcatgtt gtaaagttaa 360tagagataaa tatttttatc aaaaatttta taaacacagc ctttctttag cattgattta 420atttcagaac atcttcatat tgattattag ccataaagtt tctaacatga aacatttatc 480tataaatttt gtgattatag tagtggaata catagaaaaa aatatgcttt caactttgtg 540agtgaatttc gtgttgtgta agttatatgt caaatctttg aattttaatt ttactctttt 600atacatgtga taatttcata aagtgaggga tcccaaaaaa agagtttcat ccaacattct 660tgttctgcag gttgctttta taaagaaggt gaactatttt catgtaatgt taagagttaa 720acttatcttt cccaaatata actttattat tagcttggga aaaatgaaat tgtattccca 780tttttaaaat aaatacaaat gtttatttca gaagggcagt tttgattata tgtgaataca 840caaattttac tggatttatc ttaataaaaa gactctgacg atgattgtgt tttgttatat 900cttcaaaaat atagctagtg aaatattgtg cttaattttt ttctattgtg ttattcatga 960aaatatttaa tattcactga cataaaatta atataaagta aaattcacca ttttaattat 1020aataaaaata aagtatataa ttcaatggtt gtcagtatat tcacaatgtt gtgtccactg 1080tttaattcca gagaattttt atcacccaaa taagaaacaa agcaccaatt agcagtctct 1140tcccattttc gcccaactta tcccccacct ccatcccttg gcaaccacta atctgccttc 1200tatctctatg gatttgccta ttctgaacat ttattataaa tggaatcaca taaaaaaaaa 1260aaaaaaaaaa aggcggccgc 1280 156 604 DNA Homo sapiens misc_feature (1)...(604) n = A,T,C or G 156gnnttgtang nactnctnng gnaatccaga tctttttttt ttttttttta cgttacctct 60gnggtgattn atattctacc agtnaggata caaaatttac annancatct acnagtncca 120aaccattnat gaccttataa ttttatcgng catgaaaang gncnangaca ggantncaaa 180tggantntat gtntaaagag ttacntagta atnngtnctt gantatggtg ataaaatctg 240ctanacangt aacaggaatg tnatnaagcc tanctagaca ttatgaacac aatctgacac 300cgaagcattt ccnggttgta tcctnagctt aacaggcact ggagacngnc aggttcntca 360aatggtccat gaacacctgc aggctaacan catcnnttag gatgggtgct ncnnttgtcc 420tgtccnnaag catacaggtg attggcntgt ctgagatggg ttgactcttg gacaccggaa 480tccagcctga ctgcctacat gctccgtgtt gatgtaacga ggcatcgcga agcgagcttg 540cagaatgnnt ngagcntcat ccaatggngc ntgcngaagg ngcttgaggt tagcatnctn 600ggcc 604 157 476 DNA Homo sapiens misc_feature (1)...(476) n = A,T,C or G 157taatccaaga tctttttttt tttttttttt ttttcttggt tccaatattt attattctga 60caggttagga atactntgat aaataagtaa tattttctct tacagaaaat tgtaatgata 120ccattgagta caattaaaca ctctgagaat ttcacagaaa catcagaatt ttaatagaca 180gtagccagcg tccttgtggc cagtgtgagt gacttctcac agctgcaaac accctgggcc 240agatttctta aaacagctac atgacaaaaa caatgctatt gacatccaat aatgctaaag 300cctgggtacc acccaggctc cactgactgg tggtttccaa acatctctcc actgactggt 360ggttttcaac cacaaggaaa ggaaaatgga atattctttg gctcttccag cctagacaca 420actcctgacc taagactttg agtggagagt cctaaccctt gggaagttga actttc 476 158 1782 DNA Homo sapiens 158cggtgagccg gccgtattcc cgctctcgct tagggggcac aggcgcaggc atcggcccgg 60ccactccaag ccttcggtgc gcgggcgcgt ctgggatacg ggcccgggag gcgccgccct 120ccgtccgccc ggtgcctctc aggaacagcg aaccggagag agcgccggag agttgggctc 180agtgcggagc tcggcgccgg ggcccatgcc cgtgcgcccc cgcaggccgg cgccatggcc 240tccgggagtg tggccgagtg cctgcagcag gagaccacct gccccgtgtg cctgcagtac 300ttcgcagagc ccatgatgct cgactgcggc cataacatct gttgcgcgtg cctcgcccgc 360tgctggggca cggcagagac taacgtgtcg tgcccgcagt gccgggagac cttcccgcag 420aggcacatgc ggcccaaccg gcacctggcc aacgtgaccc aactggtaaa gcagctgcgc 480accgagcggc cgtcggggcc cggcggcgag atgggcgtgt gcgagaagca ccgcgagccc 540ctgaagctgt actgcgagga ggaccagatg cccatctgcg tggtgtgcga ccgctcccgc 600gagcaccgcg gccacagcgt gctgccgctc gaggaggcgg tggagggctt caaggagcaa 660atccagaacc agctcgacca tttaaaaaga gtgaaagatt taaagaagag acgtcgggcc 720cagggggaac aggcacgagc tgaactcttg agcctaaccc agatggagag ggagaagatt 780gtttgggagt ttgagcagct gtatcactcc ttaaaggagc atgagtatcg cctcctggcc 840cgccttgagg agctagactt ggccatctac aatagcatca atggtgccat cacccagttc 900tcttgcaaca tctcccacct cagcagcctg atcgctcagc tagaagagaa gcagcagcag 960cccaccaggg agctcctgca ggacattggg gacacattga gcagggctga aagaatcagg 1020attcctgaac cttggatcac acctccagat ttgcaagaga aaatccacat ttttgcccaa 1080aaatgtctat tcttgacgga gagtctaaag cagttcacag aaaaaatgca gtcagatatg 1140gagaaaatcc aagaattaag agaggctcag ttatactcag tggacgtgac tctggaccca 1200gacacggcct accccagcct gatcctctct gataatctgc ggcaagtgcg gtacagttac 1260ctccaacagg acctgcctga caaccccgag aggttcaatc tgtttccctg tgtcttgggc 1320tctccatgct tcatcgccgg gagacattat tgggaggtag aggtgggaga taaagccaag 1380tggaccatag gtgtctgtga agactcagtg tgcagaaaag gtggagtaac ctcagccccc 1440cagaatggat tctgggcagt gtctttgtgg tatgggaaag aatattgggc tcttacctcc 1500ccaatgactg ccctacccct gcggaccccg ctccagcggg tggggatttt cttggactat 1560gatgctggtg aggtctcctt ctacaacgtg acagagaggt gtcacacctt cactttctct 1620catgctacct tttgtgggcc tgtccggccc tacttcagtc tgagttactc gggagggaaa 1680agtgcagctc ctctgatcat ctgccccatg agtgggatag atgggttttc tggccatgtt 1740gggaatcatg gtcattccat ggagacctcc ccttgaggag gt 1782 159 1465 DNA Homo sapiens 159gaattcggca cgagggtgcc ttttaggaga aataaagagg aagatttgca atcaactaaa 60gaagagagat ttccagcgat ccacaagtcg attgctattg gctctcagcc agtgctcact 120gttgggacaa cccacatatc caaattgaca gatgaccaac tcataaaaga gtttcttagt 180ggttcttact gctttcgtgg gggtgtcggt tggtggaaat atgaattctg ctatggcaaa 240catgtacatc aataccatga ggacaaggat agtgggaaaa cctctgtggt tgtcgggaca 300tggaaccaag aagagcatat tgaatgggct aagaagaata ctgctagagc ttatcatctt 360caagacgatg gtacccagac agtcaggatg gtgtcacatt tttatggaaa tggagatatt 420tgtgatataa ctgacaaacc aagacaggtg actgtaaaac taaagtgcaa agaatcagat 480tcacctcatg ctgttactgt atatatgcta gagcctcact cctgtcaata tattcttggg 540gttgaatctc cagtgatctg taaaatctta gatacagcag atgaaaatgg acttctttct 600ctccccaact aaaggatatt aaagttaggg gaaagaaaag atcattgaaa gtcatgataa 660tttctgtccc actgtgtctc attatagagt tctcagccat tggacctctt ctaaaggatg 720gtataaaatg actctcaacc actttgtgaa tacatatgtg tatataagag gttattgata 780aacttctgag gcagacattt gtctcgcttt ttttcatttt tgttgtgtct tataaactga 840ctgtttttct ttgcttggat actgtgattc caaaataaat ctcatccaag caagttagag 900tccagcctaa tcaaatgtca taattgttgt acctattgaa agtttttaaa taatagattt 960attatgtaaa ttatagtata tgtaagtagc taatgaagta aagatcatga agaaagaaat 1020tgataggtgt aaatgagaga ccatgtaaaa tatgtaaatt ctagtacctg aaatcctttc 1080aacagatttt tatatagcaa ctgctctctg caagtagtta aactagaaac tgggcacatg 1140gtagaggctc acatgggagt tgtcctcacc cttgttaatc tcaagaaact cttatttata 1200ataggttgct tctctctcag aacttttatc tattactttt ttcttcttat gagtatgttt 1260actctcagag tatctatctg atgtagacag ttggtgatgc ttctgagact cagaatggtt 1320tactctaaca aaacactgtg ctgtctatcc cttgtacttg cctactgtaa tatggatttc 1380acttctgaac agtttacagc acaatattta ttttaaagtg aataaaatgt ccacaagcaa 1440aaaaaaaaaa aaaaaaggcg gccgc 1465 160 657 DNA Homo sapiens 160cgcggggtaa cgcggagtag cacgccatga aggcctcggg cacgctacga gagtacaagg 60tagtgggtcg ctgcctgccc acccccaaat gccacacgcc gcccctctac cgcatgcgaa 120tctttgcgcc taatcatgtc gtcgccaagt cccgcttctg gtactttgtg tctcagttaa 180agaagatgaa gaagtcttca ggggagattg tctactgtgg caggtgtttg agaagtcccc 240cctgcgggtg aagaacttcg ggatctggct gagctatgac tcccggagcg gcacccacaa 300catgtaccgg gaataccggg acctgaccac cgcaggcgct gtcacccagt gctaccgaga 360catgggtgcc cggcaccgcg cccgagccca ctccattcag atcatgaagg tggaggagat 420cgcggtcagc aagtgccgcc ggccggctgt caagcagttc cacgactcca agatcaagtt 480cccgctgccc caccgggtcc tgcgccgtca gcacaagcca cgcttcacca ccaagaggcc 540caacaccttc ttctaggtgc agggccctcg tccggggtgt gccccaaata aactcaggaa 600cgcccggtga aaaaaaaaaa aaaaaaacat aaaaaaaaac catcaaaaaa aataaaa 657 161 483 DNA Homo sapiens misc_feature (1)...(483) n = A,T,C or G 161nntttttttt tgtttttaaa aagaattgtt tatttaccga acctggggca tattagatac 60aaccaatttt aaatttacat cttttaaatc agttttgaag tgtttcacac acacaaaaaa 120cttggcatgc aacagttgtc ctaaggtgaa agtcacctca ttaataaact gttgcaagtg 180ttctcaccca aggtggaagt atggtttatc ctgaacatga aaacctgtaa caaatttaaa 240ttaattatat aaaactcgtt acttgtagtt ttgcccttgc aaagatccaa aaaaaaaaaa 300aaaaagcaca agtaactaat atgtatcagt cacaacataa tcctggatca tncccatacc 360aaaaccggat gctcttttaa ttttaaaccc atcatcagag aacaagagaa agtaatttca 420ttttacacaa aacaagattn acatgtgcca aaaaagaaat accccaaaag aaacaaaaac 480caa 483 162 956 DNA Homo sapiens misc_feature (1)...(956) n = A,T,C or G 162gacgggagct gcatgaaagc cgaagttatg gaccgctagc atctgtcact ggccaccggt 60ttccgggagt aagcggcnta ccttacagcc ctgacacgag ccgggtgctc tctcttctca 120ccgcggccca cgtctcctcg ntggctccgg tggcctcgct gggtcgcgag gaggcngagg 180actgtactct gaggccaaaa gccagagtcg gccctgaacg cccacgactc tcagggtcca 240gaggccgtga gaccggccgc ggctgaaagg taaagaaacc aagtggaaga gtgtttcctc 300ctctggccgt aaagcatgct gtcnccgccc tactcnggac cgccccaaag actcnatggg 360atggacctga gtcagccgaa tccttagccc cttccctttg gggcctgctg tggtgctcga 420catcagtgac agacggaagc agcagaccat caaggctaag gggaggnccg gggngttttt 480ttttaccagt catctacaac acatttattt gtacaatcca gaaactagca ggaccaaaat 540tagcagcaat gtgagacatt tactggcagc tttgccttct acccnaaggt caaagtactt 600gagacattgc ctgtgtgcct aaggaggcat cacacaagga aagccccacc ccctacttcc 660ttcatctgag caaaggaacc tgtttacatg cacagtgctt agtgggtggg actctccaaa 720gcagtggaaa ttcatcttta acctaattta tacaggtctg cgtcacgatg gcaaattgaa 780ggtgccatga tttagctggt ttcnctggaa cattcctttc aggngcccan actttgtcac 840actttcatgc cccaaaggga ttcaggtgct ctgggatgtc taccctggaa tacanccttg 900cctccttttc cngaggtatt gggctccagt aanccaccgg ggggttttgg aaatca 956 163 560 DNA Homo sapiens misc_feature (1)...(560) n = A,T,C or G 163tttttttttt ctgaaaacaa gttttattta aataagggtt taaatacatt acacataaca 60ttaaaacttt aggggaaaaa aaaaccaaaa accagtttgt tacttcacat ggcattgggc 120agctgctgct attaagttgc aagctctaca gctagctaca tgactgatgg atcagtttga 180gatttgttcc cttgtcaaaa gtttaactct gatagaaggt tggcctcaca ttctgatgtt 240tggacatccc ttagctagga tatgtctggt cgaacagacc tttgtggcaa gccagatgtc 300ctatcacctc gctagcggta agagggcctc tttgagctct gtccacctag tcaggttgga 360gacaccaggg gatctaccac caaaagctcc cttctagtag tacagctggt gcttctgcct 420taccccatcc tctcctctca gattcaccga ggactgttca gggtggtaac attctcttag 480ggtagggaac tctgcagagg gagagctgan gaggttccgg cctagttgtt tgtaatctta 540gggctctggg cttggctgaa 560 164 526 DNA Homo sapiens misc_feature (1)...(526) n = A,T,C or G 164tttttttttt ttggaagaat acacgaaata tgtttaatac ttagtatcaa actaaaaagt 60aatataaaat ttnaaaactt cttttttttc atgcacaggc tttttctggt aaggaccgct 120gggattgaac agaagcttcc ggtaaataag ggccccgtcg gcaagacagc atactgctgt 180cacaagtgca aacacccctc caccaactgt caatgttgtg gtttctggta tcagtgccaa 240cacagatacg atgagcatga atactgttgt taccagtgag ttgataatat ccagccgcag 300catcttcacg tggcctttca cactgaagca gaaggggccg atgttttatt ttcggctgca 360cgttatccat cgcgtctgca gacccagcag cagcactttc cctcaactct tctcagctgg 420ctgcctgagt aggttctgcg aagcgatagc aaccgccacc gcggcggagc accgccctcc 480cctacttctc ggcctcgtgc cgaattcttg gcctcgaggg ccaaat 526 165 3205 DNA Homo sapiens 165cgactcgtcg ccattcccgg agcaggtcgg cctcggccca ggggcgagta tccgttgctg 60tgtcggagac actagtcccc gacaccgaga cagccagccc tctcccctgc ctcgcggcgg 120gagagcgtgt ccggccggcc ggccggcggg gctcgcgcaa cctccctcgc ctccccttcc 180cccgcagcct ccgccccgcc aggcccggcc cggactcccg agccccggcc tcctcgtcct 240cggtcgccgc tgccgccggg cttaacagcc ccgtccgccg cttctcttcc tagtttgaga 300agccaaggaa ggaaacaggg aaaaatgtcg ccatgaaggc cgagaaccgc tgccgccgcc 360gacccccgcc ggccctgaac gccatgagcc tgggtccccg ccgcgcccgc tccgctccga 420ctgccgtcgc cgccgaggcc cccgttgatg ccgctgagct cccccaacgc cgccgccacc 480gcctccgaca tggacaagaa cagcggctcc aacagctcct ccgcctcttc gggcagcagc 540aaagggcaac agccgccccg ctccgcctcg gcggggccag ccggcgagtc taaacccaag 600agcgaattac taatttcagc tggattcaat ttgttgtcag ttgattctgt agtaaggcca 660tatgttgccc ctctggaggt gcttgtcaac tactctggat gatggatgga aagaactcca 720gtggatccaa gcgttataat cgcaaacgtg aactttccta ccccaaaaat gaaagtttta 780acaaccagtc ccgtcgctcc agttcacaga aaagcaagac ttttaacaag atgcctcctc 840aaaggggcgg cggcagcagc aaactcttta gctcttcttt taatggtgga agacgagatg 900aggtagcaga ggctcaacgg gcagagttta gccctgccca gttctctggt cctaagaaga 960tcaacctgaa ccacttgttg aatttcactt ttgaaccccg tggccagacg ggtcactttg 1020aaggcagtgg acatggtagc tggggaaaga ggaacaagtg gggacataag ccttttaaca 1080aggaactctt tttacaggcc aactgccaat ttgtggtgtc tgaagaccaa gactacacag 1140ctcattttgc tgatcctgat acattagtta actgggactt tgtggaacaa gtgcgcattt 1200gtagccatga agtgccatct tgcccaatat gcctctatcc acctactgca gccaagataa 1260cccgttgtgg acacatcttc tgctgggcat gcatcctgca ctatctttca ctgagtgaga 1320agacgtggag taaatgtccc atctgttaca gttctgtgca taagaaggat ctcaagagtg 1380ttgttgccac agagtcacat cagtatgttg ttggtgatac cattacgatg cagctgatga 1440agagggagaa aggggtgttg gtggctttgc ccaaatccaa atggatgaat gtagaccatc 1500ccattcatct aggagatgaa cagcacagcc agtactccaa gttgctgctg gcctctaagg 1560agcaggtgct gcaccgggta gttctggagg agaaagtagc actagagcag cagctggcag 1620aggagaagca cactcccgag tcctgcttta ttgaggcagc tatccaggag ctcaagactc 1680gggaagaggc tctgtcggga ttggccggaa gcagaaggga ggtcactggt gttgtggctg 1740ctctggaaca actggtgctg atggctccct tggcgaagga gtctgttttt caacccagga 1800agggtgtgct ggagtatctg tctgccttcg atgaagaaac cacggaagtt tgttctctgg 1860acactccttc tagacctctt gctctccctc tggtagaaga ggaggaagca gtgtctgaac 1920cagagcctga ggggttgcca gaggcctgtg atgacttgga gttagcagat gacaatctta 1980aagaggggac catttgcact gagtccagcc agcaggaacc catcaccaag tcaggcttca 2040cacgcctcag cagctctcct tgttactact tttaccaagc ggaagatgga cagcatatgt 2100tcctgcaccc tgtgaatgtg cgctgcctcg tgcgggagta cggcagcctg gagaggagcc 2160ccgagaagat ctcagcaact gtggtggaga ttgctggcta ctccatgtct gaggatgttc 2220gacagcgtca cagatatctc tctcacttgc cactcacctg tgagttcagc atctgtgaac 2280tggctttgca acctcctgtg gtctctaagg aaaccctaga gatgttctca gatgacattg 2340agaagaggaa acgtcagcgc caaaagaagg ctcgggagga acgccgccga gagcgcagga 2400ttgagataga ggagaacaag aaacagggca agtacccaga agtccacatt cccctcgaga 2460atctacagca gtttcctgcc ttcaattctt atacctgctc ctctgattct gctttgggtc 2520ccaccagcac cgagggccat ggggccctct ccatttctcc tctcagcaga agtccaggtt 2580cccatgcaga ctttctgctg acccctctgt cacccactgc cagtcagggc agtccctcat 2640tctgcgttgg gagtctggaa gaagactctc ccttcccttc ctttgcccag atgctgaggg 2700ttggaaaagc aaaagcagat gtgtggccca aaactgctcc aaagaaagat gagaacagct 2760tagttcctcc tgcccctgtg gacagcgacg gggagagtga taattcagac cgtgttcctg 2820tgcccagttt tcaaaattcc ttcagccaag ctattgaagc agccttcatg aaactggaca 2880caccagctac ttcagatccc ctctctgaag agaaaggagg aaagaaaaga aaaaaacaga 2940aacagaagct cctgttcagc acctcagtcg tccacaccaa gtgacactac tggcccaggc 3000taccttctcc atctggtttt tgtttttgtt tttttttccc ccatgctttt gtttggctgc 3060tgtaattttt aagtatttga gtttgaacag attagctctg gggggagggg gtttccacaa 3120tgtgaggggg aaccaagaaa attttaaata cagtgtattt tccagcttcc tgtctttaca 3180ccaaaataaa gtattgacac aagag 3205 166 1143 DNA Homo sapiens 166ctcgaggcca agaattcggc acgagggctc caaacagcag tctgaggagg acctgctcct 60gcaggatttc agccgcaatc tctcggccaa gtcctccgcg ctcttcttcg gaaacgcgtt 120catcgtgtct gccatcccca tctggttata ctggcgaata tggcatatgg atcttattca 180gtctgctgtt ttgtatagtg tgatgaccct agtaagcaca tatttggtag cctttgcata 240caagaatgtg aaatttgttc tcaagcacaa agtagcacag aagagggaag atgctgtttc 300caaagaagtg actcgaaaac tttctgaagc tgataataga aagatgtctc ggaaggagaa 360agatgaaaga atcttgtgga agaagaatga agttgctgat tatgaagcta caacattttc 420catcttctat aacaacactc tgttcctggt cgtggtcatt gttgcttcct tcttcatatt 480gaagaacttc aaccccacag tgaactacat attgtccata agtgcttcat caggactcat 540cgccctcctg tctactggct ccaaatagac catgtcagct tcaccccctg gctttgtgtc 600tatgggtggc ctgtggtata tggaaaagta gcagggtggt cagggtggga gacacaagat 660gtttttatag tctagagcct ttaaaaaaac ccagcagaat gtaattcagt atttgtttat 720tggctgtttt ttgacagatt gttgaaatta aatgaattga aagggaaact cagagtacta 780ggacgtttat taaaaggaaa aaaatgtctt gcaatgtgct gtaatcacaa gaggagaaaa 840taacttgttt ccttgatctg tcagaggtca cagtaacctg ggccgagctg ttattattta 900ttatataata gtagtaggaa gttaataact ggttctctgt gttccaagca caatattaca 960acttcctttg aaccgtaaat atcagaatga atcctcttcc caggggattg aacagaagct 1020taatgtttac aagtgtttga atttgtgatc tgaaataaca caaaattaaa aacatgattt 1080ctctaatttt ccaactagag gaagagaaaa aaaaaaaaaa aaaaaaaaaa aaactgcggc 1140cgc 1143 167 560 DNA Homo sapiens misc_feature (1)...(560) n = A,T,C or G 167ttcctttttt tttttttttt tgccgttgac tgctaatcaa aaataagcct tacctagaaa 60acagaaactg aattttcaaa cacagagaca gannaaaaaa aaaaaaccca ccaatgctac 120ctctgtaaaa taaaactaga agcaaaatga atagtttcaa gacagtcggc taaccaacaa 180accaaatgca caagagaata ctaaacaggg ttttactgtc atcaagttcg aaggcaggaa 240gacagactag aaaaggtctt aggagagatg ggctaccatg gacaaatgaa gccacactct 300atctgttaaa tctaaattct aacattaaaa ctcctgaatc ctggagttag tttaatgtca 360ctgacattaa ctagctttag ttattgtcat tttattcaaa tggatgccat ttgattaggt 420aagtattgag cattatttta ggagaaaaac caaacccaac tcctatttgc ttaggtacca 480tgtcccatga acaaaaaaga agaagagagc aaagtatttt tgagacagtc tttaagtgaa 540gccataagaa ctaagttatt 560 168 9573 DNA Homo sapiens 168ggatcctaca tgatggctac agatacagct gttgttcaag gttttagcct ggaatctctg 60ccaattcaat aacggaggca ataaaaatag acactagtat tataaagaca gaattcattt 120attttgaaag ttttgaaagc tatgaatatc taccaagaat aaaataaatt gtactgaaaa 180tatattagaa tgaattaaaa aatgccaaat tcacaactaa taaaatttat tataaagtta 240aaaattctta tatttttctg tctcagtata aaaaataaac atttaatgta tctattagaa 300aataattagc aattttgtaa atgatatcaa agaaaatttg aacaaatggt gaaatatttt 360cttatctgcg gacaccaaat taaaaaaatt caggccaggt gcagtggctc acacctgtaa 420tcccaactac tttgggaggc caaggcagga ggatctcttg atccaaggag tttaagacca 480gcctgggcag ggacgggtgc agtggctcat gcctgtaatc ccagcatttt gggaggctga 540gacggcagat catgaggtca agagatcaag accatcctgg ccaacatggt gaaaccctgt 600ctctactaaa aatacaaaaa ttagctgtac atggtgacgc atgcactcct gtagtcccag 660ctacttggga ggctgaggca ggagaatcac ttgaaccggg gaggcggagg ttgcagtgag 720ccagatcgca ccactgcact ccagcctggt gacagagcga gaccccatct caaaaaaaaa 780ttagccaggc atggcttcat gtgcctatag tcctagctac tagggaggct gaggtcggag 840gattgcttga gcctgggagg tcgaggctgc tgtgaaccga gattgtgcta ctggactcca 900gcctgggtga caaagtgaga ccctgtctca aacaaacaaa caaacaaaaa accaaaaaaa 960ccccaaaata aaacaaaaat tcaacagcat gtagattagt aatgttagtg ctttattttt 1020aaaaattatt gttaacttat atgggttttc ctctgagaag gtgcactgga aggtgtcagc 1080agagcagata gcacaaactc ctcagatttc agaagcaggg gtttatggta aatgaaaaat 1140gccagtcact tgtcagcatg cacaggtggc tatgcccgcc ctgtgtcagg ctctgtgtca 1200gtagtagggt gctccatgcg tccttttcag agtcctacat gccatctatg ctcactcagc 1260caggcctgtc acctggaagt aacaggcaac tcctcctgca ctggaattag cagcagagtc 1320aggtgaataa tgtggcctgg ccacaccacc tctcagcaaa tgtccccagt ggtgatgccc 1380gatagttccc aatcctcctt aagtaattaa ttcacttcaa ttgaattaaa aaaatcaatc 1440acttccctat gacacacaag gacattcact ctctggcttt aactatcctt gcctgccttg 1500ttattatcat tccatgtgcc caatactgtc aaaagatgta tttttgccat accctccaca 1560tgcatttcat atgtgtgatt tttattttca aattctatat ctcttctagg aatatggtgt 1620gttttatttg tcctgctgca ggactcccct ctccactcag attaaattat taaattccag 1680ataaaaaatt aacttggaat actgttgaat caatagtaga agtaaccaaa ataataaaga 1740tatttcaaaa tgaagattga tttttaaaag taaaaatgtc acatactcca cctagaagat 1800aagagactgt actacaaatt cattagaaca tccccttcat gtcatgggcc agtcatgtcc 1860ctgaacttaa cctctgtctt ctcgggtgat gttacaggcc aatgcagcat cagctgccca 1920cactcctagt ggtggaatct gggagcacag gcaggagtct gcgcctgtgg ccttggctgg 1980gtgaaagatg acatttccaa gacttcttgc ttggcagcca tcctcacgtg caggtggtct 2040ggcagcagca ctgcaaaacc caggcaaggg atgccccact gcaaggccca gtggtaactg 2100tggtggccat tggcattggg ggcagatgca gccatgtgag ttggtgggct gtggcagcca 2160ccctaatgat ggtttccacc cctcccagct ggtggtggct aaaaccaccc ggtaggagtt 2220tcaaaagcag tggcaccatt aagcggagct cctggaggag gactggaagc aactgcttgc 2280attgaaggaa tgtagctata gtggaattat tgaaccacat catatttgca aagatgcaga 2340atgtattaca gattacgaga tatggaagtt gaggttaatc tggtagagag cagtgaatat 2400gaggaggaag ctctctattg ggcgggtgct atcatagctg cagaaggtga tggtgcaatg 2460cttctgccag tgagtaaagt cttgtacaaa cttaaaccag ttacggggta aaatctgatc 2520caggactacc tgagggtcac ttatgttggc ctgttcaata cacacatttc tttccaggag 2580ccttaccaaa ggtctatagt agtgagttca gtatggaggc agtaatcaga tcatatctgg 2640aaggaactgg cataaactcc aatcctgtgg gacatcatgg acagcaacta aattcgaatc 2700aacagagtag agcccttgac attggacaag ttcgtggtga aagatctgag gctttaggac 2760tccgacattt gtgaatgaca gcactaaatg aagtctttac tggtgaacgt ctatccagaa 2820taccttatgc ttgggctgtg gcagtggata atttaagtag acccactcta tttatttatt 2880tattttgaga cggagtcttg ctctgttgcc caggctggag tgcagtggcg tgatctaggt 2940tcactgcaag ctccgcctcc caggttcacg ccattctcct gcctcagcct cccaagtagg 3000tgggactata ggcacccatc accacacctg gctaattttt tgtattttta gtagagacag 3060ggtttcaccg tgttagccag gatggtctcg atctcctgac ctggtgatcc atccgccttg 3120gtctcccaaa gtgctgggat tacaggtgtg agcctctgcg cctggctaag tagacccact 3180ctaaaagact ggtttcttac tgtgagattt cagttggtaa tggtccatgg gaaaaatgga 3240agacttcagg gctcaatttg tgaactggag caagatcaaa ggcaacaggg ttgcaagtca 3300ggctgtggag catgattaaa atattgcaaa tgacaaggac gttggagtct tgcattcaac 3360tgtaaaatga cagaataaca aataaatata atgaatcatt gttctagagt ccaaaaaggg 3420ccaaaagtaa ttttcagtat tcaagaacta aaaagcaagc agttttctcg agcacccatg 3480agcattgttt ctcctgagag atttgtcctc gttttcattg ctggaacacc tgcatggttg 3540tagatggagg aatgtctttt gatgttccta tttttatatc agacaagctt taaagcaaca 3600acagttataa aagacaaaga aggaaatttt ataatgataa aaggatcggt ccaacagaac 3660aatatcacaa tcctaaatat atatgcacct aatactggag ctcccaaatt tataaaacaa 3720ttattactag acctaagaaa tgggatagat ggcaccacaa taatagtagg ggacttcaat 3780actccatgga cagcactaga caggacatca aggcagaaag tcaataaaga aaaaattgac 3840tttaattata tcctagaaca aatagattta gcagatattt acctaacatt ctacccaaca 3900acttcagaat ataccatatt ttaatcagca catagaacgt tctccaagat aaatcataag 3960ataggccaca aaacaagtct caacaaattt aagaaaattg aaattatgtc aagtaccttt 4020tcagaccaca atggaataaa actggaaatt aactccaaaa agaaccctta aaactataca 4080aatacatgaa aattaaataa tctgctcctg aatgaccttt gggttaacaa tgaaatcaag 4140aaggaaattt aaaaattgct tgaactgaac aataatagtg acacaaccta ttaaaacctc 4200tgagatacag caaaactaag aggacagttc atagcattaa atagtctgaa acagcatgaa 4260cagacaatct aaggtgacac ctcaaggaac tcaagaaaca agaaccaacc aaactcaaac 4320ccagaagaaa agaaataaca aagatcagag cagaactaaa taaaattgaa acaaaaaata 4380caaaagataa atgaaacaaa aactggttat ttgaagagat aaacaaaatt gacagaccgt 4440tagtgagatt aaccaagaaa aaaagggaga cgatccaaat aagctcaatt agaaatgaaa 4500tgggaaatat tacaaccaat accacagaaa tatgaaagat attcaaggct actatgaaca 4560cccttatgca cacagactag aaaatctaga agagatggat aaattcctgg aaaataagtt 4620attatttgaa aaagacactt gtatggccgg gcacggtggc tcatgcctgt aatcccagca 4680ctttgggagg ataagcgggc ggatcatctg aggttaggag ttcaagacca gcctggccaa 4740catgttgaaa ctccatctct actaaaaata caaaattagc tggacatggt ggtgcatgcc 4800tgtaatcccc gctactctgg aggctgaggc aggagaatcg cttgaaccca ggaggtggag 4860gttgcagtga gccaagattg caccattgca ctccagcctg ggcaacaaga gcgaaattct 4920gtctcaaaaa aaaaaaaaaa aaaaaaaaga agaaaagaaa aagacacttg cacacatgtt 4980tatagcagta caatttgcaa ttgcaaaaat atgcaaacag tataaatata catcaaccaa 5040tgagtgaata aagaaaacgt tattttttta tttttagacg gaatttcgct tttgttgccc 5100aggctggagt gcaatggtat gatctaggtt taccgcaacc tctgcctcct gggttcaagt 5160gattctcttg cctcagcttc ccgagtagct gggattacag gcatgtacca ccacgtccag 5220ctaattttgt atttttagta gagacagggt ttctccatgt tggtcaggct ggtctcgaac 5280tcctgacctc agatgatctg cctaccttgg cctcccaaag tgctgggatt atgggcatca 5340gccactgcac ccagccaaaa atgtgatttt atatatatat atataatata caccatgaaa 5400tactactcag acctaaaaag gaataaaata atggaatttg cagcaacctg gatggagttg 5460gcctcgttta ctactctggg tttctgtctg aggatgaggg tgatgattgc tgatcaggat 5520gcggaaggaa cccagtgcta acccacagca tctgccccac agggaaataa ggcacaagtc 5580tcttgtttga tcccacgcta tgacctctag acctactctt ccctcttgtc accaaaacca 5640caatcaggaa aaatttctgc aggcatttca ccatcctgga acaaggatct gagactcttc 5700actgaatttg tgaccttcta tccagccaat atttatactg agctattaag attaacatct 5760tagcctggtc attgccacac aggcaggcaa ggcagctcag gtggaaaata cttttggtca 5820tcccatgtgt ctgggcatat ggccttgatg tgagtttatg ttcatgctca ggacaagtta 5880tgggtcaggg gactagtcag cttatgggcc aggaaaaggt gctaaggttt gtggagtcaa 5940agagggaatt cacacatatt aatgctcctt gtttccacct aaggcagttt gtgaagtctg 6000tgggttctgt gactgtccac aaatggagca ggaacattcc ttagaacgga tgattgggac 6060cccacaaagg aaaagacaag aggaagcaca ggctacacaa tgaaaataca cttggtcatg 6120ccaaaggcta ggtcatgcca aaggctaatg aaagagcttt gagtataatt cagtgccttt 6180ggggttgagt ggaaaataca aaaaccatct ttgccctgct ctcacaccac aacaatcaac 6240acgtttccat gaccaaatgt gtaggatttc tccccacccc ctagaaagca agccattggt 6300tttgcagcgg acaccacaca ggtgccctct cattgaatgc aattctgaca ctatccacat 6360ggagacaggg tcagatctta cagtttgagg gctacttccc caagactgtg ccccactact 6420tacgccaatc ccaagcctca gattgcttta cctgtgcttc tgtccaaata gctgtaagtt 6480gaagatttca caacatctcc ttggcttcta ttaatttgct agaatggctc acagagctca 6540gtagacactt acaggtttat taaaaaggat acaaccaagc atatagatga agacatgcat 6600agcacaaggt atgggaagtg gtgcaccacc gtccagtaat cttcatgtgt tcagccttcc 6660agaagttctc ccagcctagc tccatttggg ttattttatg gacgcttcct caccgaggct 6720ttatggagta aaccactgcc cattggtgaa taatcggcag cccctctccc ctccacagag 6780gttgggagat gaggctgaaa gtcccatccc tctaacactg ccttggtctt tcttgtgacc 6840tgcccccatc ctgaagttac ctagggactg tcagccaaca gtcatctcat tagcatacaa 6900aaagactctg gtgattttaa gtattttagg agttgtataa caagaaatgg ggtcaaagac 6960caaaaccata atttataata acacagggat gaaaaagaaa gtagaggttg atgatttcaa 7020gcccacacta gtcctcatta tgacagatgt ggatttccaa cccataagag gcaggaggct 7080gaagagctga gacgaaacct gtgaaaagca gggacagggg acatttctca atttcttgtt 7140actgaagtga tagagctcca ccaggcctca cttggattga caaactaaat taaaagatac 7200actctttaaa taaaaagcac ttctgagcat acatccaaaa gaatgaaaat caggatattg 7260cagaaatatt tgcacatttt tattcatgca gcattaatca caatttcaaa gacatggaga 7320cagcataagg tccactaatc attgaatgtt tacagaaaat gtggtgtata gctgcaatgg 7380atgctgttca aattcaagaa gaattaggcc gggcacggtg gctcccgcct gtaatcccgg 7440cactttggga ggccaaggcg ggcggatcac aaggtcagga gttcaagacc agcctgacca 7500atatggtgaa accccgcccc tactaaaaat accaaaatta actgggtgtg gtggcagaag 7560cctgtaattc tagatactca ggaggctgag gcaggagaat ctcttgaatc cgggaggcag 7620aggttgcagt gagctgagat tgcgccactg cactccagcc tgggtgacag agtgagactc 7680tgtctctcaa aaaaaaaaga ataattaaat tttgccatat gcagcaacag ggaaaaccct 7740ggaggatatt acactgagtg aaataagcca atcttagaag gggaaatgct gcacggcctc 7800atttatatga ggtatctaat tttttttttt cgagacagag ttttgctctt gtcacccagg 7860ttggagtgca atggcgcgat ctcagctcat tgcaacctcc gcctcccggg ttcaagcgat 7920tctcctgcct cagcctcctg agtagctggt attacaagtg cctgccacca cacctggcta 7980atttttgtat ttttagtaga gacacagttt caccatgttg gccaagctgg tctcgaactc 8040ctgacctcag gtgatccgcc tgcctcgacc tcccaaagtg ctgggattac aggcatgagc 8100caccacgtcc ggcctatagg aggtgtctaa tatactcaac cgagcagaaa tggagtagaa 8160tgctggttgc caggggtagg gagagaagga aatggggagt cactgctcaa gggctatgaa 8220gctttaggtt tgcaaaatga acaagttcta gagatgtgct gtacaacact gtgcttacag 8280ctgacaacac tgtattatgt acttaaaatt ttattcagag ggtatatcac acattaaacg 8340ttcttattaa catgaaaaag ggatagaaaa taccatgaaa ccacttacag aaagcaagta 8400tggcaatcct ctgtcctttg tcttgggaga aagttttggc caagagacaa tttaggcaaa 8460aaagagaatt tactgaagaa aaacagagag caaatagttt atttagagag acagtgtact 8520ctggaagata aggcagagcg ggctgctgat agagaatgag ccagcggccc gagaaatgtg 8580cactgagttt ttatgatatt gcactttttc ttggagttcc cacctctgtt ttaagtctcc 8640accttttttt ctttctctag tttttctgct tcagccttaa gtccctgcct tttccccaca 8700tagtttccag cccaggctgt gggaccctcc cttaacacac acatgggccc agtgtttgat 8760aggaattcta cctaatggct gcattgctca ttactgccac cccaggaagg ttgtatggtg 8820gtcaaatcta tacttactgt acctgcatct ctcttagaaa tttctccttt gctctcaccc 8880ctattatcag catgcagcta gctacattct gacaggttaa cttcagagtg agtgaatact 8940gggtgtctta aggggctttg ttctggcata ggtatttacc ctaatctctg ttcgtatcta 9000gcatgtgtgc tttgggtggt ctctggggtg tgagattttc cagaactccc ttttctcagg 9060ggctgcccct cctgcttctg tctagctatc tgcctactct aaagttagta ttagtatgaa 9120agcttttatg aaaaacattt ttttccaaga aaagggaggc attttatact ggtgaaataa 9180ggtgttcaat gacaacacat aacaactgta aattgtatgc acctaataaa atagctttaa 9240agtatttgaa gcaaaactgt ctcttttagc agaattaaaa agagaaataa tcaatccata 9300atcatataca cagatattaa tacaactctc ttattaactg agtgaatgac atggagaaaa 9360aagagtatac atacaaatac gtgaaaacca tgattaacaa aatcaatcca gtgacaccag 9420gaacccaagc ctgaagggta gttgcttgag tatgcattca tggatgaacg catccaatga 9480atcatcacag gaacaaacaa ttgaggcctt cgtttatgta tttctaactg atgttaagtt 9540tttccttcct attctgtgag tagaggtgga tcc 9573 169 1180 DNA Homo sapiens 169ggagcggcgg cccctgagag gaagcggcga agatggccat gaacattttc cggctgactg 60gggacctgtc ccacctggcg gccatcgtca tcctgctgct gaagatctgg aagacgcgct 120cctgcgccgg tatttctggg aaaagccagc ttctgtttgc actggtcttc acaactcgtt 180acctggatct ttttacttca tttatttcat tgtataacac atctatgaag gttatctacc 240ttgcctgctc ctatgccaca gtgtacctga tctacctgaa atttaaggca acctacgatg 300gaaatcatga taccttccga gtggagtttc tggtggtccc tgtgggaggc ctctcatttt 360tagttaatca cgatttctct cctcttgaga tcctctggac cttctccatc tacctggagt 420ccgtggctat ccttccgcag ctgtttatga tcagcaagac tggggaggcc gagaccatca 480ccacccacta cctgttcttc ctgggcctct atcgtgcttt gtatcttgtc aactggatct 540ggcgcttcta ctttgagggc ttctttgacc tcattgctgt ggtggccggc gtagtccaga 600ccatcctata ctgtgacttc ttctacttgt acattacaaa agtactcaag ggaaagaagc 660tcagtttgcc agcataagtt gccaaagacc atcaccagca tctgtccttc agggtgctcg 720gacagaattc ttaccacagc aaaggcataa gatgcttgat acggaaaatc agaaacttaa 780ctcttttgtt gcagatagtc atcagtggct ctgtaaaaac gcagaggaaa agagccagaa 840ggtttctgtt taatgcatct tgccttatct ttttttatta ctgtgtacaa agattttttt 900acacaaagaa acttaatgct gtattaataa attcagtgtg tagcttcaat tgggatagtt 960ccaaaagtga agattttgtg aggaataagt gcaaattttt tttttatttt aaaaaattct 1020ttgaaactct taagtctttg tgtctgcaat gaaattgtac tccttgacag ttgatagatt 1080atgtattctt ccatccctca aacttgcatt ccactatatt tattttttgg caaaagatga 1140gctgtatttg tttgaaatct gagacactat gttcaattgg 1180 170 1267 DNA Homo sapiens 170cagcgagcgg ctgcagcggg gccgtgacca gcagccagcg ggaggcggcg gcgagtcggt 60gagcagctgg gaagagcaga accggggcgg agcacctgca ggcgcgggcg gcggccccac 120catggcgatt cgcaagaaaa gcaccaagag ccccccagtg ctgagccacg aattcgtcct 180gcagaatcac gcggacatcg tctcctgtgt ggcgatggtc ttcctgctgg ggctcatgtt 240tgagataacg gcaaaagctt ctatcatttt tgttactctt cagtacaatg tcaccctccc 300agcaacagaa gaacaagcta ctgaatcagt gtccctttat tactatggca tcaaagattt 360ggctactgtt ttcttctaca tgctagtggc gataattatt catgccgtaa ttcaagagta 420tatgttggat aaaattaaca ggcgaatgca cttctccaaa acaaaacaca gcaagtttaa 480tgaatctggt cagcttagtg cgttctacct ttttgcctgt gtttggggca cattcattct 540catctctgaa aactacatct cagacccaac tatcttatgg agggcttatc cccataacct 600gatgacattt caaatgaagt ttttctacat atcacagctg gcttactggc ttcatgcttt 660tcctgaactc tacttccaga aaaccaaaaa agaagatatt cctcgtcagc ttgtctacat 720tggtctttac ctcttccaca ttgctggagc ttaccttttg aacttgaatc atctaggact 780tgttcttctg gtgctacatt attttgttga atttcttttc cacatttccc gcctgtttta 840ttttagcaat gaaaagtatc agaaaggatt ttctctgtgg gcagttcttt ttgttttggg 900aagacttctg actttaattc tttcagtact gactgttggt tttggccttg caagagcaga 960aaatcagaaa ctggatttca gtactggaaa cttcaatgtg ttagctgtta gaatcgctgt 1020tctggcatcc atttgcgtta ctcaggcatt tatgatgtgg aagttcatta attttcagct 1080tcgaaggtgg agggaacatt ctgcttttca ggcaccagct gtgaagaaga aaccaacagt 1140aactaaaggc agatcttcta aaaaaggaac agaaaatggt gtgaatggaa cattaacttc 1200aaatgtagca gactctcccc ggaataaaaa agagaaatct tcataatgaa ttataaacta 1260attgatt 1267 171 520 DNA Homo sapiens misc_feature (1)...(520) n = A,T,C or G 171aatccaagat cttttttttt tttttttttt tttttttttt tttttcagtt acacttttcc 60ttgctttaat attttttgtc tttttctgct tttgaaatga gctctcaatt acaaaatacc 120aaactacact caaaagaggg tgtanaaaaa gccagccatt ggcncagcat gganaagccc 180acaagtaagg acagatagca gcagcaggng gcaagaggtg ggaggtgact gaagcagngg 240ttacaaatgt tcacaggaag ctaaaactat ccaacaggtt gngccctaat gttagcncag 300gttanactag ttactacctt gctaggnggc ctcagngngt tcanattnta cgcagcaata 360caatttnttc cagttaanag ttcttgactt gcaccgatca cagcatggtt gaagggtact 420ggaccagtct tgttagtttt tcaaaatgct gtcgtaaacc tgatanatgt attgagagac 480ttcaggagct ntacncttca gtgacagcgt gtaattgggg 520 172 1653 DNA Homo sapiens 172gcggccgcag tttttttttt tttttttttt tttttttagc caaacagatt ggtcattatt 60gtacacatag ctggaaggga ggggtggtcc cggggtaagg acagggctgc ccaatatttg 120gggggaggaa gggactcttc ttccaaatgg gcttgtccgg gaaccggggt cccggggagc 180tgggcgcctg gtccacatgg accccctcca cctccccaca tacgctgtgg aagaagggca 240ggagtgagaa atgctggggg aggacgaccc tttggtctga gatgtggagg tgatcataac 300agttcccgcc cgctggctgt tttgttgact ttggagaggc cttcccggaa cccagagtcc 360gtcattactt gctccatctg aacatcctcc tcgtcctcct ggggcagctg caggtacggg 420ttgttccctg tgggctggaa cttgtagccc gtgagcacga agaaggccag ggtggagccc 480tccaccaaga gctggtacag ccactgccac tgaaagggca cagccacctg cagcaggatg 540gcgatgatgc gggtgaagta gacgtagcag atgaccatga catagtaatg ccggaacagc 600ttcagcttgg ccaggttcac tgccaccttc ccgtctgtgc cagacgcatc ctggagatgc 660cggatggacc agactacggg gaacaggatg gcaccacagc agatgaggtc caccaggaac 720aaaatctcct tccacagcac gtagtcgctg gcgccttcct cgcgggactc gatgatgatg 780taggccacgt tggccaggac ctgcatgggg atcacgatcc caaagacctt cttctcctta 840tccgacagga cgtacttgat gaaggcccag cctgagccaa tcagggcgat ggtgatgaag 900aggagggcgc ccttcagcag gtgtgcgatg tagtacatga cggcaaggcc ttcgatgggg 960tggccctggc tgttgatgaa gtagtagttg atgctgtgga agaggagaga gatgctcttg 1020gtgaaggcca aggccgccat gagccagtgg atcttgaaga cgctgtacgt gttcctgcag 1080aggatggaca cccagaagat gccagcggcc aggaagcagg cggacatgac catgtagagc 1140ttgaaaaggg gcatctccgc tgccgacagg aagccatcgg ggttcttctc ccggatcatc 1200accgtgatgt cgaatggatg ctcctttcct ggcactgaat tgttgcagtt gtggaagttc 1260aggctgtact ggccttcttc cgcctgagag ccgatcacca cgtggaaact gaagttgtag 1320gagttgttga ggtggctcag gcccaacacc aggtccttgt ccttcccact aggaccctga 1380atcactgcgg gtgttgactt gggcttgctg gctgcagagg tccctccgcc atccaccttg 1440cgggggactg tggcctgtgg cttcgggagc cctggtttgg agggtgcttc cgggaggagc 1500ccgggaaaga taaacaacgt cttctgctct ccatacttcc gcacctggac ctgcagatcc 1560ttggtgttga tgaggaacag gaccaggaaa ctgctactgt ttttctggag agggcagtcc 1620tggaaatccc gggttggcct cgtgcccgaa ttc 1653 173 532 DNA Homo sapiens misc_feature (1)...(532) n = A,T,C or G 173aggcccaaaa cgagaacatn naananccgt tttttccnca naaaagccnt tttnanaaag 60cacagcaaga cnngnctgcg gacacacagg aggcacacgg acagcccgcc aaccagagag 120ggagacgaag gccagcgagg ctctcacagg ccagcgnggc tcncacaggg cagcgcatcn 180canaacccct ggcccccctc gngccaaggc tggccngagn caggccacgc ccacgccgcc 240ntangacaaa tagaggccgg agccaaggag gnggcaacag agcaggggca aggaaggnan 300ccncaggttc ngataangac ccngcaaatc ccaccccacc ctcaggcacc nccggcnaag 360gggaccggan accccaggna aggaggnacc caggagggcc gnggnaaccc tagggctgac 420gaaacnagct ccgacaagcc aggccacngg gaggnacctc aggatggaaa agatgctgga 480ggcnnagntg gcatcangaa gccgggagcc ccacgggggc aaaaggggag gg 532 174 1246 DNA Homo sapiens 174ctcgaggcca agaattcggc acgagagact tgctaggaag aaatgcagag ccagcctgtg 60ctgcccactt tcagagttga actctttaag cccttgtgag tgggcttcac cagctactgc 120agaggcattt tgcatttgtc tgtgtcaaga agttcacctt ctcaagccag tgaaatacag 180acttaattcg tcatgactga acgaatttgt ttatttccca ttaggtttag tggagctaca 240cattaatatg tatcgcctta gagcaagagc tgtgttccag gaaccagatc acgattttta 300gccatggaac aatatatccc atgggagaag acctttcagt gtgaactgtt ctatttttgt 360gttataattt aaacttcgat ttcctcatag tcctttaagt tgacatttct gcttactgct 420actggatttt tgctgcagaa atatatcagt ggcccacatt aaacatacca gttggatcat 480gataagcaaa atgaaagaaa taatgattaa gggaaaatta agtgactgtg ttacactgct 540tctcccatgc cagagaataa actctttcaa gcatcatctt tgaagagtcg tgtggtgtga 600attggtttgt gtacattaga atgtatgcac acatccatgg acactcagga tatagttggc 660ctaataatcg gggcatgggt aaaacttatg aaaatttcct catgctgaat tgtaattttt 720tcttacctgt aaagtaaaat ttagatcaat tccatgtctt tgttaagtac agggatttaa 780tatattttga atataatggg tatgttctaa atttgaactt tgagaggcaa tactgttgga 840attatgtgga ttctaactca ttttaacaag gtagcctgac ctgcataaga tcacttgaat 900gttaggtttc atagaactat actaatcttc tcacaaaagg tctataaaat acagtcgttg 960aaaaaaattt tgtatcaaaa tgtttggaaa attagaagct tctccttaac ctgtattgat 1020actgacttga attattttct aaaattaaga gccgtatacc tacctgtaag tcttttcaca 1080tatcatttaa acttttgttt gtattattac tgatttacag cttagttatt aatttttctt 1140tataagaatg ccgtcgatgt gcatactttt atgtttttca gaaaagggtg tgtttggatg 1200aaagtaaaaa aaaaaaaaaa aaaaagatct ttaattaagc ggccgc 1246 175 1223 DNA Homo sapiens 175ctcgaggcca agaattcggc acgaggccag caagtgtttt acaggtgcct tggattaaaa 60caaaattgat tttaaaattt ttatgtaagt cattgtgtct atgatgccac ttttaaaagg 120aaaatgcaat tgcgtaatgg cttatatcct tatttaatgt acctatttgt gttctaataa 180ttgtttgaat gttttattca gcttaaaact ttaccatgaa gtcataaaca gtaaacaatg 240ttttgttatg tattaagggg atatcagtgt ttctcaaagt atgatccatg gaccatctgg 300gtcatggcgc ctggtttcag acaacctgaa tcaaatctta ggggtggggc tttgggatgt 360cattgttcaa taggcacctc aggagattct gagcacacca atgtttgaga accactaaaa 420tgaggagtgg gaaaaaaaaa ataggtgttt tgttaattta gagctgagct gagaagataa 480tatattttta ttgtcaatga cattaacaga tatgcactga ttcttttata cctacaattt 540acttaatgtt ccttttatta aaacgcgtgg ttcatgagca actacagact gaatccagat 600tattacctgt tgctttcagt attttcgtga tggcttttaa tcttatgaaa tcatcttgag 660atcattcatg gtcaagccat gaaaactccc atcttcaagc ctgcctgcta aagcttcttt 720gccttcctga ttgtgattat ggtaacaatt tatatcagac agttgtactt tttgataact 780tagggaaaac agaaatgact tgaacaaggg attgcctgcc tcactgcatt gcagagatac 840aatttctgta aagaacacaa atagcagttg tgaatattaa ggtgtgatta tctttccctg 900tccatgtgct tattgaaaga agatagtgaa caaatgatta tattgaggat ttttttaatt 960tataagatct aatgtgaaat ccacacttgg aactttttag atctgtctgt tgcttgttta 1020atatatttct tttatgacat tacttaaagt ttaaaagggt tttctatcca ctgtcaattt 1080caattggata acattttgtc aagttttttt tttcctgatt atttgatgct agctggaatt 1140caagaaatgg cattgacctt attcaaataa agaaatattt tagtaaaaaa aaaaaaaaaa 1200aaaaaaaaaa aaaaggcggc cgc 1223 176 2780 DNA Homo sapiens 176gtgggcggac cgcgcggctg gaggtgtgag gatccgaacc caggggtggg gggtggaggc 60ggctcctgcg atcgaagggg acttgagact caccggccgc acgccatgag ggccctgtgg 120gtgctgggcc tctgctgcgt cctgctgacc ttcgggtcgg tcagagctga cgatgaagtt 180gatgtggatg gtacagtaga agaggatctg ggtaaaagta gagaaggatc aaggacggat 240gatgaagtag tacagagaga ggaagaagct attcagttgg atggattaaa tgcatcacaa 300ataagagaac ttagagagaa gtcggaaaag tttgccttcc aagccgaagt taacagaatg 360atgaaactta tcatcaattc attgtataaa aataaagaga ttttcctgag agaactgatt 420tcaaatgctt ctgatgcttt agataagata aggctaatat cactgactga tgaaaatgct 480ctttctggaa atgaggaact aacagtcaaa attaagtgtg ataaggagaa gaacctgctg 540catgtcacag acaccggtgt aggaatgacc agagaagagt tggttaaaaa ccttggtacc 600atagccaaat ctgggacaag cgagttttta aacaaaatga ctgaagcaca ggaagatggc 660cagtcaactt ctgaattgat tggccagttt ggtgtcggtt tctattccgc cttccttgta 720gcagataagg ttattgtcac ttcaaaacac aacaacgata cccagcacat ctgggagtct 780gactccaatg aattttctgt aattgctgac ccaagaggaa acactctagg acggggaacg 840acaattaccc ttgtcttaaa agaagaagca tctgattacc ttgaattgga tacaattaaa 900aatctcgtca aaaaatattc acagttcata aactttccta tttatgtatg gagcagcaag 960actgaaactg ttgaggagcc catggaggaa gaagaagcag ccaaagaaga gaaagaagaa 1020tctgatgatg aagctgcagt agaggaagaa gaagaagaaa agaaaccaaa gactaaaaaa 1080gttgaaaaaa ctgtctggga ctgggaactt atgaatgata tcaaaccaat atggcagaga 1140ccatcaaaag aagtagaaga agatgaatac aaagctttct acaaatcatt ttcaaaggaa 1200agtgatgacc ccatggctta tattcacttt actgctgaag gggaagttac cttcaaatca 1260attttatttg tacccacatc tgctccacgt ggtctgtttg acgaatatgg atctaaaaag 1320agcgattaca ttaagctcta tgtgcgccgt gtattcatca cagacgactt ccatgatatg 1380atgcctaaat acctcaattt tgtcaagggt gtggtggact cagatgatct ccccttgaat 1440gtttcccgcg agactcttca gcaacataaa ctgcttaagg tgattaggaa gaagcttgtt 1500cgtaaaacgc tggacatgat caagaagatt gctgatgata aatacaatga tactttttgg 1560aaagaatttg gtaccaacat caagcttggt gtgattgaag accactcgaa tcgaacacgt 1620cttgctaaac ttcttaggtt ccagtcttct catcatccaa ctgacattac tagcctagac 1680cagtatgtgg aaagaatgaa ggaaaaacaa gacaaaatct acttcatggc tgggtccagc 1740agaaaagagg ctgaatcttc tccatttgtt gagcgacttc tgaaaaaggg ctatgaagtt 1800atttacctca cagaacctgt ggatgaatac tgtattcagg cccttcccga atttgatggg 1860aagaggttcc agaatgttgc caaggaagga gtgaagttcg atgaaagtga gaaaactaag 1920gagagtcgtg aagcagttga gaaagaattt gagcctctgc tgaattggat gaaagataaa 1980gcccttaagg acaagattga aaaggctgtg gtgtctcagc gcctgacaga atctccgtgt 2040gctttggtgg ccagccagta cggatggtct ggcaacatgg agagaatcat gaaagcacaa 2100gcgtaccaaa cgggcaagga catctctaca aattactatg cgagtcagaa gaaaacattt 2160gaaattaatc ccagacaccc gctgatcaga gacatgcttc gacgaattaa ggaagatgaa 2220gatgataaaa cagttttgga tcttgctgtg gttttgtttg aaacagcaac gcttcggtca 2280gggtatcttt taccagacac taaagcatat ggagatagaa tagaaagaat gcttcgcctc 2340agtttgaaca ttgaccctga tgcaaaggtg gaagaagagc ccgaagaaga acctgaagag 2400acagcagaag acacaacaga agacacagag caagacgaag atgaagaaat ggatgtggga 2460acagatgaag aagaagaaac agcaaaggaa tctacagctg aaaaagatga attgtaaatt 2520atactctcac catttggatc ctgtgtggag agggaatgtg aaatttacat catttctttt 2580tgggagagac ttgttttgga tgccccctaa tccccttctc ccctgcactg taaaatgtgg 2640gattatgggt cacaggaaaa agtgggtttt ttagttgaat tttttttaac attcctcatg 2700aatgtaaatt tgtactattt aactgactat tcttgatgta aaatcttgtc atgtgtataa 2760aaataaaaaa gatcccaaat 2780 177 998 DNA Homo sapiens misc_feature (1)...(998) n = A,T,C or G 177gataacccca tcttgtatac ctgtggtgac caacatggag gccttctcat cagaacattt 60caacttagag atctatcgcc aaaatctgca gaccaagcag ttggggaaag taattttgtt 120tgccgaagtg acccccacaa cgatgcgtct cctggatggg ctgatgtttc agacaccgca 180ggaaatgggc ttaatagtga tcgcggcccg gcagaccgag ggcaaaggac ggggagggaa 240tgtgtggctg agccctgtgg gatgtgctct ttctactctg ctcatctcca ttccactgag 300atcccagctg ggacagagga tcccgtttgt ccagcatctg atgtccgtgg ctgtngtggg 360aagcagtgag gtccattccc gagtattcag gatattcaac tttacggagt gnaagtgggc 420ccaacggtna tttatttaca gtggacctca tgaagatcng gcggattctg ggttaactca 480acantcatgg ggaggaaaca tttatatact tatttgggtg ttggatttaa tgtggantaa 540cagttaacct taccatttgc atcaacgacc ttatnacaag tgtcacaaga atgttcttac 600agttcagtac ctccccagat gcttacaaac agtgatagca tacctctaac tcaccactgg 660cctgggcgca agagcatatt ttggtttgtt ttttcataga ctaggggtaa aggtctgcac 720tactaagaaa atatctgaat tttcccattg tcatttccat gtaaaaactc cccttgacaa 780taaacgtaag tccaagccac agaggggaga gcaatttccc acctgtggga gggctttccc 840taaactaaat tttctacttc ttaaccatct atcccagagc ctcttcaaac accaaagaaa 900acgacaacaa aacaaaccta aaaacaaaca ggaaacacag ganaaaggaa caaaggnctt 960taaccaaatg anttgggagg gaaaggaaaa tttcacct 998 178 2780 DNA Homo sapiens 178gtgggcggac cgcgcggctg gaggtgtgag gatccgaacc caggggtggg gggtggaggc 60ggctcctgcg atcgaagggg acttgagact caccggccgc acgccatgag ggccctgtgg 120gtgctgggcc tctgctgcgt cctgctgacc ttcgggtcgg tcagagctga cgatgaagtt 180gatgtggatg gtacagtaga agaggatctg ggtaaaagta gagaaggatc aaggacggat 240gatgaagtag tacagagaga ggaagaagct attcagttgg atggattaaa tgcatcacaa 300ataagagaac ttagagagaa gtcggaaaag tttgccttcc aagccgaagt taacagaatg 360atgaaactta tcatcaattc attgtataaa aataaagaga ttttcctgag agaactgatt 420tcaaatgctt ctgatgcttt agataagata aggctaatat cactgactga tgaaaatgct 480ctttctggaa atgaggaact aacagtcaaa attaagtgtg ataaggagaa gaacctgctg 540catgtcacag acaccggtgt aggaatgacc agagaagagt tggttaaaaa ccttggtacc 600atagccaaat ctgggacaag cgagttttta aacaaaatga ctgaagcaca ggaagatggc 660cagtcaactt ctgaattgat tggccagttt ggtgtcggtt tctattccgc cttccttgta 720gcagataagg ttattgtcac ttcaaaacac aacaacgata cccagcacat ctgggagtct 780gactccaatg aattttctgt aattgctgac ccaagaggaa acactctagg acggggaacg 840acaattaccc ttgtcttaaa agaagaagca tctgattacc ttgaattgga tacaattaaa 900aatctcgtca aaaaatattc acagttcata aactttccta tttatgtatg gagcagcaag 960actgaaactg ttgaggagcc catggaggaa gaagaagcag ccaaagaaga gaaagaagaa 1020tctgatgatg aagctgcagt agaggaagaa gaagaagaaa agaaaccaaa gactaaaaaa 1080gttgaaaaaa ctgtctggga ctgggaactt atgaatgata tcaaaccaat atggcagaga 1140ccatcaaaag aagtagaaga agatgaatac aaagctttct acaaatcatt ttcaaaggaa 1200agtgatgacc ccatggctta tattcacttt actgctgaag gggaagttac cttcaaatca 1260attttatttg tacccacatc tgctccacgt ggtctgtttg acgaatatgg atctaaaaag 1320agcgattaca ttaagctcta tgtgcgccgt gtattcatca cagacgactt ccatgatatg 1380atgcctaaat acctcaattt tgtcaagggt gtggtggact cagatgatct ccccttgaat 1440gtttcccgcg agactcttca gcaacataaa ctgcttaagg tgattaggaa gaagcttgtt 1500cgtaaaacgc tggacatgat caagaagatt gctgatgata aatacaatga tactttttgg 1560aaagaatttg gtaccaacat caagcttggt gtgattgaag accactcgaa tcgaacacgt 1620cttgctaaac ttcttaggtt ccagtcttct catcatccaa ctgacattac tagcctagac 1680cagtatgtgg aaagaatgaa ggaaaaacaa gacaaaatct acttcatggc tgggtccagc 1740agaaaagagg ctgaatcttc tccatttgtt gagcgacttc tgaaaaaggg ctatgaagtt 1800atttacctca cagaacctgt ggatgaatac tgtattcagg cccttcccga atttgatggg 1860aagaggttcc agaatgttgc caaggaagga gtgaagttcg atgaaagtga gaaaactaag 1920gagagtcgtg aagcagttga gaaagaattt gagcctctgc tgaattggat gaaagataaa 1980gcccttaagg acaagattga aaaggctgtg gtgtctcagc gcctgacaga atctccgtgt 2040gctttggtgg ccagccagta cggatggtct ggcaacatgg agagaatcat gaaagcacaa 2100gcgtaccaaa cgggcaagga catctctaca aattactatg cgagtcagaa gaaaacattt 2160gaaattaatc ccagacaccc gctgatcaga gacatgcttc gacgaattaa ggaagatgaa 2220gatgataaaa cagttttgga tcttgctgtg gttttgtttg aaacagcaac gcttcggtca 2280gggtatcttt taccagacac taaagcatat ggagatagaa tagaaagaat gcttcgcctc 2340agtttgaaca ttgaccctga tgcaaaggtg gaagaagagc ccgaagaaga acctgaagag 2400acagcagaag acacaacaga agacacagag caagacgaag atgaagaaat ggatgtggga 2460acagatgaag aagaagaaac agcaaaggaa tctacagctg aaaaagatga attgtaaatt 2520atactctcac catttggatc ctgtgtggag agggaatgtg aaatttacat catttctttt 2580tgggagagac ttgttttgga tgccccctaa tccccttctc ccctgcactg taaaatgtgg 2640gattatgggt cacaggaaaa agtgggtttt ttagttgaat tttttttaac attcctcatg 2700aatgtaaatt tgtactattt aactgactat tcttgatgta aaatcttgtc atgtgtataa 2760aaataaaaaa gatcccaaat 2780 179 2475 DNA Homo sapiens 179ccggaggagt ccgagaggaa gcggaggcgc gagctggagg cggcggctcc cgtcggcctc 60cggcaggact gagcgctggg aggccggaag gcgggcgcgc acggcggaga ggcgggcggg 120aggccggagc atattaatga aaagtgccat aaactgaaaa accaaacatg agggtagcag 180gtgctgcaaa gttggtggta gctgtggcag tgtttttact gacattttat gttatttctc 240aagtatttga aataaaaatg gatgcaagtt taggaaatct atttgcaaga tcagcattgg 300acacagctgc acgttctaca aagcctccca gatataagtg tgggatctca aaagcttgcc 360ctgagaagca ttttgctttt aaaatggcaa gtggagcagc caacgtggtg ggacccaaaa 420tctgcctgga agataatgtt ttaatgagtg gtgttaagaa taatgttgga agagggatca 480atgttgcctt ggcaaatgga aaaacaggag aagtattaga cactaaatat tttgacatgt 540ggggaggaga tgtggcacca tttattgagt ttctgaaggc catacaagat ggaacaatag 600ttttaatggg aacatacgat gatggagcaa ccaaactcaa tgatgaggca cggcggctca 660ttgctgattt ggggagcaca tctattacta atcttggttt tagagacaac tgggtcttct 720gtggtgggaa gggcattaag acaaaaagcc cttttgaaca gcacataaag aacaataagg 780atacaaacaa atatgaagga tggcctgaag ttgtagaaat ggaaggatgc atcccccaga 840agcaagacta atggaaatgt ggagagaatt gaagaaagcg cactttcact cttaatggga 900gagctataaa tggcagagct atgtgtaaat attttaagag catgcagcca tcttggtgtg 960tgcatgagta ttgtctcttt tgatatcagg attatttatt gctaacgtaa atagatagca 1020ttgtaaataa tcatcacaat gatcaaatca ctgaaccatg tctccgcaca tttccctaaa 1080agtacaatgt ttagactgct atggtaatac atattttaaa ttctaaaagc atacacaatg 1140tgtaactgaa tggtttgtga aaaatatatt gatatatata ctagttgcta tgaaaatatc 1200atggaataat agggatttta gggtggatac tttattttct tttatgtttc tatatgttgc 1260gttgtgatga cattatcttt taaattaaaa agagatttgg ctagttgtgt gtgtaatgtt 1320actttacagt ccgactctcc tgatgtacct cttttcatga tctttttctt tccttcccaa 1380gaaactgagg aatgtttaat atgaaaacat acatcggata tgtgaaaagc acaacaaaat 1440tcttaatgta cacagtaaaa aagtaaatat ataaatgtag atggcattta ggaccacagc 1500ttgctggatt tgtgttagct atgggaataa cttgattttg tataagctat ttagagtgag 1560gctggaggtg gcagcttcac agaactggag aaccaggcca agtcccctcc ccaacctaat 1620taggtcattc aggacagcta agtcagtata tttagagcaa tactagcata cgtttttctt 1680aattgttatc agcattgacc aagtggtttg gaaggaggca tgctttaata tcacaataat 1740tttgatttgt aaaccaagaa attaatcctg tgtttatcta acttcataat agcaattatt 1800gcccgaagct atagtggcat atttacaaaa gttcttatta ctgggcggac tgataacatt 1860taaaaaataa ttgtgtttga ccccaaatga ctttataccc aattctacat aaaaatatag 1920aagatctatc tttttttgtt accttcagat gttcactaaa taactcagtt tttaagcaga 1980agttttcagg gcattaaata tatgttgtgt atgaagtatc tcaaactgga acataaattt 2040agtgatcaaa ctgccattca cagtgtaagg cagcacttaa atttcgaacc taaagtttag 2100atgcattgta taaaaaaacc taaaagcagt atctgttatt tagctgtaaa ccaagttgga 2160agctattcgg ataatttctt aaatattgat gaactttgga gtactgtttc ttccttcaaa 2220ctgaatgtaa ttaattcatg aataaatgca ccttatatgt ttaaacaatc tttgtatact 2280tttgggattt ttggtgctta tatgctaaat cacattcagc atgtgtattt tgacatttaa 2340aatacttccc tcaattctgt aaattaaaag aatagttatt ttacagttcc agggattgtg 2400aaataaatgt tgcagttttt taaaataatg aaaataaata ctcttggttt tgctttgtga 2460aaaaaaaaaa aaaaa 2475 180 823 DNA Homo sapiens misc_feature (1)...(823) n = A,T,C or G 180gctggagaaa ggaatgtgct catcaccagt gccctccctt acgtcaacaa tgtcccccac 60cttgggaaca tcattggttg tgtgctcagt gccgatgtct ttgccaggta ctctcgcctc 120cgccagtgga acaccctcta tctgtgtggg acagatgagt atggtacagc aacagagacc 180aaggctctgg gaggagggac taacccccca ggagatctgc gacaagtacc acatcatcca 240tgctgacatc taccgctggt ttaacatttc ngtttgatat ttttggtcgc accaccactc 300cacagcagga ccaaaatcac ccaggacatt ttccagcagt tgctgaaacg aggttttgtg 360ctgcaagata ctgtgagaga ttcgtacatt tatttattac tgtccctatc tattaaagtg 420actttctatg agccaaggtc ttttactttt tcttcttgcc tttaggggct tcagggggtt 480tcccctcagc tacagccaac tgtttcttta gatccaagag tttcgccacc tccgcagcaa 540cctcgttctt gtctgccttt tgtgctttca gttctcggac aatgtttcct tgttttgtca 600cttcatccat cagcgcttgt atctgctgtg gcttggctgt tgtaacagtc tctacaactg 660ctggcttcgg ggacgttttt gcctggcccc ctccaaagcg ctgccttaaa ctttcaatct 720ggtcattttc caatttttgg aacaagggac tgactgtgcc aatctggtgt cctgctggta 780aggtacacag gaagtttgtc agcaggatac tgcaggctgg gag 823 181 415 DNA Homo sapiens misc_feature (1)...(415) n = A,T,C or G 181tttttttttt ttatggatgc actgttacat gtttatttag cgaaggtgac ttggaaaagg 60agattcacat acttccactg tatcctccgg gtaagttttc cttctcttct gtanatgtct 120ccatgttaca gtcaactata aaacatggct catgttcact ctgggcttcg ccttcagagg 180agtttgatat tttggaagtg gtacctttgt tctgtgtgct tttcagacca accgcttctt 240tcatttcttc aaggcttnct tccaaaggag ttaaatcatc atcatgtcct tttggaagag 300cagggtcctc aatggtgtaa gaaaagccat ttccctntgg gcatgcgtct tctttcccag 360cctgtctaca acaccttagg gcttcttcag gggcagaagt cacgcaactt gaagt 415 182 1601 DNA Homo sapiens 182gcggccgctt aattaaagat cttttttttt tttttttttt ttttttcaca aataaaccaa 60ctttaataga tattattttg tatttatata gtgccttctt caagaacctt aaatgcttta 120cagacattat ctctaattaa tccccacaac aaccctgtga ggtaggtatt actcccattt 180tacaagacag ggagactgaa gcacagagag gttaagtgac ttgcccaagg tcacacagtt 240aaattcactg aagagccagg acatgagcgc tttagcctcc cagctcccag ccaaatacct 300catgatagaa tctttaataa aaagtgtttt taaagaaagt atcaagagta gttatgttat 360gaaaatgagg tctttctact gccatcaagg aaagaaaaaa ccctatactg atggttagag 420gccccaagac ccatataata caacatttcc ctctttccct gttcccaagc ctcctggttc 480ctgtcttaaa taatctttta aaggtaaaat ttccaagaca gaagccatgt gacttaagaa 540gtgggactta atttagaata tttactttta gttacaataa tttatagaaa tttttattcc 600aatatacaaa atatgggaca gccatcccaa caatcatgta catagttaca cggcaatcag 660ccaccactta caacttacac cagccccgca ttttaatcac agtcaaccaa catacaacct 720cacgatgctt tcttcatggg tcacttttct tacttactat acctgtattt ttcccccaac 780cctgacccta tacgttttaa aagtacattt agtttctgat aaacttcaaa acattttact 840tagatccagc tgcattaaga agaaaaagta aatgtaaaac tgtcacccca caatccctcc 900cctgacaaat catactatga agtacggtgt agatgtgaac aagtatgtga ttaccaggaa 960ctcaacacat acactagaac ttgctttaat atgaaattta acttggcttt tacggcatgt 1020ttttttttaa tgcaaaaatg taaaaacaaa cacaacatag tatttcaatg ctgtaccttt 1080atgcaaatga cttcatctat ctttcttaaa catgttgata tagctaatgt taaaactgac 1140acagcttcac tttcctcttt ttctctgtac cgaaagctgc agaaatacag ctttaattcc 1200aagacaattt ggtttaagcc ttcaaaataa aaagagtgca tccacttcca ctgccctgac 1260tttccccaca ctgttgattg tgattctctg tggcatgttg gtagatcagg ctggcttata 1320tataatttgt acaaaacacc tctagccagg gtaaggcttt aggaactatc ttaaaaagaa 1380acttgtcaaa atactttttg atattttgta caaatactaa atattataat tttctcccag 1440aacatccgtt taagcagccc aattaagtga ctctgttaaa ggtctgctta tggaaaaaat 1500aggtgaagtc atttcctgag ccaaaagata cagataataa atgttaataa tagcagcaga 1560ctaaaaaatt cctttttgtt gttttccctc gtgccgaatt c 1601 183 1056 DNA Homo sapiens 183ctcgaggcca agaattcggc acgaggagtc atcagatatt ttagccacct acacaaaagc 60aaactgcatt tttaaaaatc tttctgagat gggagaaaat gtattctcct ttcctatacc 120gctctcccaa caaaaaaaca actagttagt tctactaatt agaaacttgc tgtacttttt 180cttttctttt aggggtcaag gaccctcttt atagctacca tttgcctaca ataaattatt 240gcagcagttt gcaatactaa aatatttttt atagacttta tatttttcct tttgataaag 300ggatgctgca tagtagagtt ggtgtaatta aactatctca gccgtttccc tgctttccct 360tctgctccat atgcctcatt gtccttccag ggagctcttt taatcttaaa gttctacatt 420tcatgctctt agtcaaattc tgttaccttt ttaataactc ttcccactgc atatttccat 480cttgaattgg tggttctaaa ttctgaaact gtagttgaga tacagctatt taatatttct 540gggagatgtg catccctctt ctttgtggtt gcccaaggtt gttttgcgta actgagactc 600cttgatatgc ttcagagaat ttaggcaaac actggccatg gccgtgggag tactgggagt 660aaaataaaaa tatcgaggta tagactagca tccacataga gcacttgaac ctcctttgta 720cctgtttggg gaaaaagtat aatgagtgta ctaccaatct aactaagatt attatagtct 780ggttgtttga aataccattt ttttctcctt ttgtgttttt cccactttcc aatgtactca 840agaaaattga acaaatgtaa tggatcaatt taaaatattt tatttcttaa aagccttttt 900tgcctgttgt aatgtgcagg acccttctcc tttcatggga gagacaggta gttacctgaa 960tataggttga aaaggttatg taaaaagaaa ttataataaa agggatactt tgcttttcaa 1020aaaaaaaaaa aaaaaaaaaa aaattggtgc ggccgc 1056 184 1215 DNA Homo sapiens 184gaattcggca cgaggaggtg aaggacccag aggacaaggt catcctggcc cggcagtatg 60gctccgaggg caggttcact ttcacttccc atacccctgg tgagcaccag atctgtcttc 120actccaattc caccaagttc tccctctttg ctggaggcat gctgagagtt cacctggaca 180tccaggtagg tgaacatgcc aatgactatg cagaaattgc tgctaaagac aagttgagtg 240agttgcagct acgagtgcga cagctggtgg aacaagtgga gcagatccag aaagagcaga 300actaccagcg gtggcgagag gagcgattcc ggcagaccag tgagagcacc aaccagcggg 360tgctgtggtg gtccattctg cagaccctca tcctcgtggc catcggtgtc tggcagatgc 420ggcacctcaa gagcttcttt gaagccaaga agcttgtgta gctgtcccag gcgtcacaac 480ccatcctccc aggctggggg agaaaggacc tcctggaact gacttcttct gtcaggagga 540ctggtttcca gccatacctg ttctggaagg gagaggggct ggaggcaccc acaggcacaa 600gctgaaggca gcagcttggc taatactgag caggtagtgg ggcaaattcc tgccctctct 660ctctggcctc tgggccgttt ggtagtaatc acccaggggc tggtaaagcc cctcctcttg 720gcacctcaga atcacagtgt tactgatcag ggatgtgagg ctgctgttgg gggtgggggg 780aggggaatgg gcaggcaagc cagtcttctg tcttcctttg ctaacttagg gttttgagca 840ggttggggta tggtgcctgt catacccacc tgccaccctg ggaacctcac tgttctctct 900ttcagcctag acctgctgat ccagggtgtg tgtgagttga gggtgggtgg aggggtttgc 960agtgtgggaa tgtggccctg cagttgacct gagctgcttc acatggttgt ccattctggg 1020gcttaaagaa ctgggaccag accaagtaga ggccttggtg ctggttgggg tggggcctgc 1080agagtcttag ttactgattt cattttcaat aaatgtaggt ttgttacatg agtttcccaa 1140ttaaaaaaaa aatgacttct tgtccagtga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1200aattggtgcg gccgc 1215 185 836 DNA Homo sapiens 185ctcgaggcca agtattcggc acgaggggca agtctactgc gggctggtcc gggctcctca 60ggttcagacc cgaccgttat ccagtcggtt cgtggagagg agaggtgcac tttacaggtc 120cctgatgaac caagagaacc ctccaccata tccaggccct ggtccaacgg ccccataccc 180accttatcca ccacaaccaa tgggtccagg acctatgggg ggaccctacc cacctcctca 240agggtacccc taccaaggat acccacagta cggctggcag ggtggacctc aggagcctcc 300taaaaccaca gtgtatgtgg tagaagacca aagaagagat gagctaggac catccacctg 360cctcacagcc tgctggacgg ctctctgttg ctgctgtctc tgggacatgc tcacctgacc 420agaccagccc agccgtcctg tcctgccagc tctgctgcca cctctgacag gtgtgcctgc 480ccccatctct tctgattgct gttaacaaat gactagcttt gcacagacac ctctaccttc 540agcactatgg gattctagat taatgggggt tgctactgtt taattcagtg acttgatctt 600tttaatgtcc aaaatccatt tcttattgat ctttaaagat gtgctaaatg acttttttgg 660ccaaaggctt agttgtgaaa aatataattt ttaaattata cattcaaggt agtggccaaa 720tgtaacacat caatcatgga atgatttctc tgctaacagc cgcctgtatg tttcaataaa 780tttgtccaaa gctcaaaaaa aaaaaaaaaa aaaaaaaaaa aaattggtgc ggccgc 836 186 495 DNA Homo sapiens 186gcggccgcat cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt 60ttcaataaat acatgctgat ttattacagg gataagatgg tttcttgggg gatagattca 120agaggagttg agaatgtttt attcatttac aatgtccctt tcctggaagg gtggacagca 180agatttagga caagctaaaa tcatccccta tttaaaaaaa aaaaaaaaaa aaaagtcacc 240agcaagtagt cccgggtggg aggtgggagc agaataaaaa aaaatctgca atgattccta 300attgtttttc aatacagaag cttgggaagg ggtttctgcc agtttcatga ggaaggcaca 360acttccaggt agtgttgggg aagggtatga ggtcctatgc aggctggcct cttatcccac 420agatgccaag atgatgtcta ctggcagctc ctccaaactt ctggctgtcc ctcgtgccga 480attcttggcc tcgag 495 187 525 DNA Homo sapiens misc_feature (1)...(525) n = A,T,C or G 187tccttttttt tttttttttt aggtgattac aacagctgat ttttattttt cttnttgatt 60ctcttctaca gttttcaaat tctctacaat gaacatgtac ttctttttaa tatcaaaaga 120caaaagaatt ggtacgtaaa aagaacatcc ttcccatctt caaggtcaag attgaacgct 180gactcctgca ggaagtcttc caggattccc aggcaggaat gatggctccc tgtccctgta 240gctccaggag ttcttgcttc acgcacgcct cacataccag actgaatgtt ggcaggagga 300gtgaccaggt cggtcatctg tgtccctacc acctacaaca ggccagcaat ctacccgtgt 360gtgtttgttg gacagaatta accatgatgg gcggccgagg gcgcctggag ctatttgggg 420gcttggagag aacctcttag gagagtgtca ggccctaggc cagtgtcacc agaggaggtc 480agtctcagtc cttggagtgg tgggatggaa accagacggg actgg 525 188 2274 DNA Homo sapiens 188gcggccgcac tttttttttt tttttttttt tttttttttt tttcacaacg cctatttatt 60ccccacacgt cacgccctgc accccgggtg ggcttggcac acacctcacc gccatgaacg 120gctgcagggc cgcggtggcc cccgttccta ctgctaccta cgatacacgg tactgcgcct 180acctcacaga cggccaggag ccagggagcc ccaggatgct ccgactgaca accctgctgc 240tgggaccacg gcgccgtggg ctcgtctgcc acccccaggc ctcaggaacc cagacaggct 300gcccgctgtc cggctctccg gctgctttcc tggtggctgt tttagggcca aggtgggtgg 360cacctgaggt gtcccgtggc ctccacccag cacaggaggg gtaagcttcc ctggggggcc 420ccgggcccat gaaacatcca ggacagaagg acagcaggat gggacacaga cagaaacggc 480ccagctgcct tccctgtgcc cggggctaag gcggccggga cagaaggtca tgatgtcgcc 540cctggctctc agtcgcgagg accagaaaat gagggtggga ggaggggaaa catgtctgtc 600aacatgccca actggagaaa agtcacagaa actggtccta tgcacccagg acggctcctg 660agccacggag gcgtggggtg accgcagccg tctcttaggt gtctgccact aaagagttcc 720tcatgcaaac acacatggcc cgcggtgccc aggccgcagc tggcagtgag ctcttccgag 780caggcacagg gccggggtgg ccgggaggtc gactcggaaa gaggcttctc acagacggga 840gagttcctgc agacagacca cgggatgggg ggcgggggct gtaaaaggct ttggaagcca 900cacgatccgc cacacggctg aacgtgaaac ctgccacttc tctgagagcg gcccgggagc 960accccaggat tctagaaaac actcaagtga ccgagctttc tgggggctgg aagggaggtc 1020gctgctggtc tgtgctcagc ttgctggctc tcgtttcaag aagggtctgg gggctgtaag 1080ggagttacaa aaagggagtg gaggagggca gagataaaag gggaaaatcc atcttgacat 1140gcaggtccga ggtctctctc ttcccctctc tcaggcagtc caacaggagg aagtggcaga 1200caaccagaag gcttccttcg ggtcggccag ggaaggacgc ggtcacaccg ggagcaggca 1260gcgtcactcc tgctggtcgt cgttgctggc gctgggcgtc cgactccgga tctggctcct 1320gagctgctct atcaactctg ggttctgctg ctgcatctgc tgggcaaact gctggcccgc 1380ctggatgagg ctggccaggt cgttctgcga ggggctggtg ccgggagttc ccaaggggtt 1440gttgccaccc gaaatcatgc cggacatgag ctgctgaatc tggggattgt tcattaggtt 1500cgaagccatg ctcatgaagc cagggttgtt cagcaggccg gcgatgtcga agctgcccac 1560gcctcccgtg gggctggggg cctcccgcag cttcagctcc gctatcttga ggttggactt 1620gtatgtctcg ttgtcggggt ccagctccag cgccttcttg tagtaagcca cggcctccac 1680gtgcttgttg aggctggaga gcgccaggcc catcctgccg taggccttgc tgtaggccgg 1740gtcaatgcag atggcccgct cacagtcctg caccgcgcct gcgtagttgc cgagtttgct 1800gtaggctgcg gctctgttgc agaaatagac ggcgttggct gggttgagct cgatggcttt 1860tccgtagaaa tgcacggcag cttcaaagtt ttccactttc atctgctcgt ttccttcggt 1920tttgaggcgc tctgcctctg ctgagtcctc ctcggaaggc ggggttcgcg ctgggctcct 1980caggtcctgc ggcatctcct tgcccgtggc agccgcttca aatatctccg gcagagtctg 2040agggagcgca aggtcactgt cttctaccgt caccccaaac gcagtctcca ggcactggat 2100ggcgacttcc aagctctcct gagcatcgga cgagaggccc ccgtgccgga gctggtcatg 2160caggaactgg atgatggcgt aggccaggcg cttcttgttg tccatcttga gcccagaaga 2220ggtgatacct ctcaggcgac cgatccccga cccaccgacc ctcgtgccga attc 2274 189 2373 DNA Homo sapiens 189gcacgagcgg ttctgagcat tagtttgaga actcgttccc gaatgtgctt tcctccctct 60cccctgccca cctcaagttt aataaataag gttgtacttt tcttactata aaataaatgt 120ctgtaactgc tgtgcactgc tgtaaacttg ttagagaaaa aaataacctg catgtgggct 180cctcagttat tgagtttttg tgatcctatc tcagtctggg ggggaacatt ctcaagaggt 240gaaatacaga aagccttttt ttcttgatct tttcccgaga ttcaaatctc cgattcccat 300ttgggggcaa gtttttttct tcaccttcaa tatgagaatt cagcgaactt gaaagaaaaa 360tcatctgtga gttccttcag gttctcactc atagtcatga tccttcagag ggaatatgca 420ctggcgagtt taaagtaagg gctatgatat ttgatggtcc caaagtacgg cagctgcaaa 480aagtagtgga aggaaattgt ctacgtgtct tggaaaaatt agttaggaat ttggatgggt 540aaaaggtacc cttgccttac tccatcttat tttcttagcc ccctttgagt gttttaactg 600gtttcatgtc ctagtaggaa gtgcattctc catcctcatc ctctgccctc ccaggaagtc 660agtgattgtc tttttgggct tcccctccaa aggaccttct gcagtggaag tgccacatcc 720agttcttttc ttttgttgct gctgtgttta gataattgaa gagatctttg tgccacacag 780gatttttttt ttttttaaga aaaacctata gatgaaaaat tactaatgaa actgtgtgta 840cgtgtctgtg cgtgcaacat aaaaatacag tagcacctaa ggagcttgaa tcttggttcc 900tgtaaaattt caaattgatg tggtattaat aaaaaaaaaa aaaaaaaact cgctcgtgcc 960gaattcggca cgaggaacaa cctgtgtgca tgctttttga gtatattaat cagggggatc 1020tccatgagtt cctcatcatg agatccccac actctgatgt tggctgcagc agtgatgaag 1080atgggactgt gaaatccagc ctggaccacg gagattttct gcacattgca attcagattg 1140cagctggcat ggaatacctg tctagtcact tctttgtcca caaggacctt gcagctcgca 1200atattttaat cggagagcaa cttcatgtaa agatttcaga cttggggctt tccagagaaa 1260tttactccgc tgattactac agggtccaga gtaagtcctt gctgcccatt cgctggatgc 1320cccctgaagc catcatgtat ggcaaattct cttctgattc agatatctgg tcctttgggg 1380ttgtcttgtg ggagattttc agttttggac tccagccata ttatggattc agtaaccagg 1440aagtgattga gatggtgaga aaacggcagc tcttaccatg ctctgaagac tgcccaccca 1500gaatgtacag cctcatgaca gagtgctgga atgagattcc ttctaggaga ccaagattta 1560aagatattca cgtccggctt cggtcctggg agggactctc aagtcacaca agctctacta 1620ctccttcagg gggaaatgcc accacacaga caacctccct cagtgccagc ccagtgagta 1680atctcagtaa ccccagatat cctaattaca tgttcccgag ccagggtatt acaccacagg 1740gccagattgc tggtttcatt ggcccgccaa tacctcagaa ccagcgattc attcccatca 1800atggataccc aatacctcct ggatatgcag cgtttccagc tgcccactac cagccaacag 1860gtcctcccag agtgattcag cactgcccac ctcccaagag tcggtcccca agcagtgcca 1920gtgggtcgac tagcactggc catgtgacta gcttgccctc atcaggatcc aatcaggaag 1980caaatattcc tttactacca cacatgtcaa ttccaaatca tcctggtgga atgggtatca 2040ccgtttttgg caacaaatct caaaaaccct acaaaattga ctcaaagcaa gcatctttac 2100taggagacgc caatattcat ggacacaccg aatctatgat ttctgcagaa ctgtaaaatg 2160cacaactttt gtaaatgtgg tatacaggac aaactagacg gccgtagaaa agatttatat 2220tcaaatgttt ttattaaagt aaggttctca tttagcagac atcgcaacaa gtaccttctg 2280tgaagtttca ctgtgtctta ccaagcagga cagacactcg gccagaaaaa aaaaaaaaaa 2340aaaaaactcg agggggggcc cgtacccgat cgc 2373 190 566 DNA Homo sapiens misc_feature (1)...(566) n = A,T,C or G 190agggantaag cttgcggccg cttaattaaa naanatttag cgtaaaatta cacttaaaca 60ttatcagctg ctgctgggaa aaaatggaca aattgcccag gcagccacat tagaagaaga 120aagtcattng aatacagnta tatacttatt tttattgaga cacatcttgc tgngtcaccc 180agggttttgc tctgttgcca cagcttactg cagccgtgac ccaggctcaa gtgatccctc 240ccacctcagg cccctctccc cgaccagtag ccgagactac aggcaggcac agactggcac 300caccacactc ggctaatttt ttttttttga ggcagggtct cactatgttg tccaggctgg 360tcttgaactc ctgagctcaa gtgatcctct naccttggct tccaaagtgc tgggattaca 420gacaagtcat ggcanctggc tgagtacagt tattcancat aagcataaca aatacagaat 480ggcagcccag ttcctttgnt aatgaaatng taaggggtgt actagggcaa gctggccctg 540attatgtcac atgagtttgg tttaga 566 191 775 DNA Homo sapiens 191gaattcggca cgaggcagga actccaatgt atcttgtgat ttttccagaa ggtacaaggt 60ataatccaga gcaaacaaaa gtcctttcag ctagtcaggc atttgctgcc caacgtggcc 120ttgcagtatt aaaacatgtg ctaacaccac gaataaaggc aactcacgtt gcttttgatt 180gcatgaagaa ttatttagat gcaatttatg atgttacggt ggtttatgaa gggaaagacg 240atggagggca gcgaagagag tcaccgacca tgacggaatt tctctgcaaa gaatgtccaa 300aaattcatat tcacattgat cgtatcgaca aaaaagatgt cccagaagaa caagaacata 360tgagaagatg gctgcatgaa cgtttcgaaa tcaaagataa gatgcttata gaattttatg 420agtcaccaga tccagaaaga agaaaaagat ttcctgggaa aagtgttaat tccaaattaa 480gtatcaagaa gactttacca tcaatgttga tcttaagtgg tttgactgca ggcatgctta 540tgaccgatgc tggaaggaag ctgtatgtga acacctggat atatggaacc ctacttggct 600gcctgtgggt tactattaaa gcatagacaa gtagctgtct ccagacagtg ggatgtgcta 660cattgtctat ttttggcggc tgcacatgac atcaaattgt ttcctgaatt tattaaggag 720tgtaaataaa gccttgttga ttgaaaaaaa aaaaaaaaaa aaaaaaggcg gccgc 775

Claims

1. A method for determining whether a compound can be used to treat prostate cancer, comprising:a) measuring the expression level of a nucleic acid comprising SEQ ID NO:1 in prostate cancer cell sample in the presence and absence of the compound; and b) identifying the compound as useful for treating prostate cancer when the expression level of the nucleic acid in the presence of the compound is less than the expression level of the nucleic acid in the absence of the compound.

2. The method of claim 1 wherein the expression level of the nucleic acid is determined by measuring the mRNA encoded by the nucleic acid.

3. The method of claim 1 wherein the expression level of the nucleic acid is determined by measuring the amount of protein encoded by the nucleic acid.

4. The method of claim 1 wherein the expression level of the nucleic acid is determined by measuring the activity of the protein encoded by the nucleic acid.