Claims
- 1. A method for modulation of proliferation of target cells in a localized region of the eye, said method comprising:
- contacting said localized region with a polymer implant with which is reversibly associated a modulating agent, wherein said modulating agent is released from said polymer implant into said localized region at a rate such that said modulating agent primarily affects target cells in said localized region of the eye as compared to cells outside said localized region.
- 2. The method according to claim 1, wherein said target cells are lens epithelial cells.
- 3. The method according to claim 1, wherein said target cells are fibroblasts.
- 4. An intraocular device comprising:
- a biologically inert polymer which is reversibly chemically associated with a proliferation modulating agent.
- 5. The device according to claim 4, wherein said proliferation modulating agent is daunomycin.
- 6. The device according to claim 4, wherein said biologically inert polymer is nylon.
- 7. The device according to claim 6, wherein said nylon is a powder.
- 8. A method for killing residual lens epithelial cells in an eye following cataract surgery, said method comprising:
- implanting an intraocular device comprising a biologically inert polymer associated reversibly with a proliferation inhibiting modulating agent into the anterior or posterior chamber of said eye, so that said proliferation inhibiting agent kills substantially all of said residual lens epithelial cells.
- 9. A method for preventing formulation of scar tissue in a region, said method comprising:
- implanting a device comprising a biologically inert polymer associated reversibly with a modulating agent into said region, wherein said modulating agent inhibits the growth of fibroblasts in said region and thereby prevents said formation of scar tissue.
- 10. The method according to claim 9, wherein said region is an ocular filtration site.
- 11. The device according to claim 4, wherein said proliferation modulating agent is ricin.
- 12. The device according to claim 4, wherein said biologically inert polymer is polymethylmethacrylate.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of U.S. Ser. No. 08/329,366, filed Oct. 26, 1994, now abandoned, which disclosure is incorporated herein by reference.
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
329366 |
Oct 1994 |
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