Claims
- 1. A method of treating asthma, while reducing hypersensitivity, which comprises administering to a human suffering from asthma an amount of (R,R)-formoterol, or a pharmaceutically acceptable salt thereof, sufficient to result in bronchodilation, said (R,R)-formoterol containing at least 99% by weight of (R,R)-formoterol and less than 1% by weight of (S,S)-formoterol.
- 2. A method of providing relief from bronchospasms, while reducing hypersensitivity, which comprises administering to a human an amount of (R,R)-formoterol, or a pharmaceutically acceptable salt thereof, sufficient to diminish bronchospasms, said (RR)-formoterol containing at least 99% by weight of (R,R)-formoterol and less than 1% by weight of (S,S)-formoterol.
- 3. The method of claim 2 wherein (R,R) formoterol is administered by subcutaneous injection, intravenous infusion, inhalation, transdermal delivery or oral administration.
- 4. The method according to claim 3 wherein the amount administered by inhalation is about 1 .mu.g to about 100 .mu.g per day.
- 5. The method according to claim 3 wherein the amount administered orally is about 0.1 to about 1 mg per day.
- 6. The method according to claim 2 wherein (R,R) formoterol fumarate dihydrate is administered.
- 7. The method of claim 1 wherein (R,R) formoterol is administered by subcutaneous injection, intravenous infusion, inhalation, transdermal delivery or oral administration.
- 8. The method according to claim 7 wherein the amount administered by inhalation is about 1 .mu.g to about 100 .mu.g per day.
- 9. The method according to claim 7 wherein the amount administered orally is about 0.1 to about 1 mg per day.
- 10. The method according to claim 1 wherein (R,R) formoterol or pharmaceutically acceptable salt thereof is administered together with a pharmaceutically acceptable carrier.
- 11. A method according to claim 7 wherein (R,R) formoterol fumarate dehydrate is administered.
- 12. A method according to claim 8 wherein said amount is administered in divided doses from two to four times a day.
- 13. A bronchodilator composition in the form of a powder for inhalation which comprises a pharmaceutically acceptable carrier suitable for inhalation and an amount of (R,R)-formoterol, or a pharmaceutically acceptable salt thereof, sufficient to alleviate bronchospasms but insufficient to cause hypersensitivity, said (R,R)-formoterol containing at least 99% by weight of (R,R)-formoterol and less than 1% by weight of (S,S)-formoterol.
- 14. A composition according to claim 13 adapted for administration by inhalation wherein the amount of (R,R) formoterol is about 6 .mu.g to about 25 .mu.g.
- 15. A composition according to claim 13 which comprises (R,R) formoterol fumarate dihydrate.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9107196 |
Apr 1991 |
GBX |
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation of earlier application, Ser. No. 08/613,382 filed Mar. 7, 1996, now U.S. Pat. No. 5,795,564, which was a continuation-in-part of earlier application, Ser. No. 08/373,515 filed Jan. 12, 1995, now abandoned, which was a continuation-in-part of application Ser. No. 08/222,319 filed Apr. 4, 1994, now abandoned, which was a continuation of application Ser. No. 07/927,458, filed Aug. 10, 1992, now abandoned. This application is also a continuation-in-part of application, Ser. No. 08/382,744 filed Feb. 2, 1995, now abandoned, which was a continuation of application Ser. No. 08/223,798 filed Apr. 6, 1994, now abandoned, which was a continuation of application Ser. No. 07/862,907, filed Apr. 3, 1992, now abandoned. The entire disclosures of these applications are incorporated herein by reference. Application Ser. No. 07/862,907 claims the priority, under 35 USC 119, of Great Britain application 9107196.9, filed Apr. 5, 1991.
US Referenced Citations (7)
Foreign Referenced Citations (3)
Number |
Date |
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2255503 |
Nov 1992 |
GBX |
9205147 |
Feb 1992 |
WOX |
9205147 |
Apr 1992 |
WOX |
Continuations (4)
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Parent |
613382 |
Mar 1996 |
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Parent |
927458 |
Aug 1992 |
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Parent |
223798 |
Apr 1994 |
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Parent |
862907 |
Apr 1992 |
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Continuation in Parts (2)
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373515 |
Jan 1995 |
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Parent |
222319 |
Apr 1994 |
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