1. TECHNICAL FIELD
The present invention provides novel methods for the diagnosis of preeclampsia by determination of both lower and higher levels of proteins and/or polynucleotides or combinations thereof in patient tissue samples. Furthermore, it presents methods of treatment of preeclampsia through either inhibition of function of proteins or polynucleotides that are expressed higher in preeclampsia, or through replacement therapy of proteins or polynucleotides that are expressed lower in preeclampsia.
1.2 Sequence Listing
The sequences of the polynucleotides and polypeptides of the invention are listed in the Sequence Listing and are submitted on a compact disc containing the file labeled “821A.txt”-4.69 MB (4,921,344 bytes) which was created on an IBM PC, Windows 2000 operating system on Thursday, Apr. 1, 2004 at 12:22:06 PM. The Sequence Listing entitled “821A.txt” is herein incorporated by reference in its entirety. A computer readable format (“CRF”) and two duplicate copies (“Copy 1” and “Copy 2”) of the Sequence Listing “821A.txt” are submitted herein. Applicants hereby state that the content of the CRF and Copies 1 and 2 of the Sequence Listing, submitted in accordance with 37 C.F.R. §1.821(c) and (e), respectively, are the same.
2. BACKGROUND
Preeclampsia is a disorder complicating 5% of pregnancies in U.S. Moreover, it is the second major cause of maternal death in both U.S. and Japan, and is the leading cause of neonatal morbidity and mortality. It is a maternal disease, presenting with wide spectrum of symptoms, including hypertension, edema, proteinuria, fatigue, rapid weight gain, cardiac, pulmonary and renal failure. Pregnancy can further be complicated with hemolytic and liver manifestations, i.e. disease can progress into HELLP syndrome (Hemolysis, which is the breaking down of red blood cells, Elevated Liver enzymes, and Low Platelet count), or can progress into eclampsia, manifested by seizures and eventual death.
The fact that there is no effective predelivery treatment and that ultimately, the treatment of choice is delivery of the placenta, leads to two observations: First, there is a substantial lack of understanding of both etiology and pathophysiology of the disorder. Suggested treatments are symptomatic and include seizure prophylaxis with use of magnesium sulfate, aspirin (generally unsuccessful), and prevention by increasing the dietary intake of calcium. Attempts of mapping the genes or loci involved have yielded no obvious success, leaving the root cause of the disorder unknown. Secondly, research on the subject of preeclampsia has revolved around placental growth and angiogenesis, as both are central to the etiology of the disease. Available evidence implicates the placenta in the maternal systemic effects seen in preeclampsia. Therefore, extracellular placental factor(s) secreted by the placenta are likely to be synthesized by the placenta and may be useful in the diagnosis and therapy of preeclampsia.
Several differentially-expressed genes have been previously examined for roles in both diagnosis and treatment of preeclampsia. Despite this fact, there remains no reliable diagnostic nor treatment for this disease. Thus, there exists a need in the art to identify and develop agents, such as peptides, nucleic acids, or antibodies that provide therapeutic compositions and diagnostic methods for treating and identifying preeclampsia.
3. SUMMARY OF THE INVENTION
This invention is based on the discovery that SEQ ID NO: 1-852 encode nucleotides that are either up-regulated or down-regulated in preeclamptic placenta as compared to control placenta. SEQ ID NO: 853-1704 comprise the protein or protein fragments encoded by the nucleotide sequences of SEQ ID NO: 1-852.
The invention provides therapeutic and diagnostic methods for targeting tissue or tissue samples expressing SEQ ID NO: 853-1704 by using diagnostic, therapeutic, or targeting elements such as SEQ ID NO: 853-1704 polypeptides, and nucleic acids encoding said SEQ ID NO: 853-1704 polypeptides. SEQ ID NO: 1-852 exhibit differential expression profiles in preeclampic placental tissue samples as compared to healthy placental tissues (see Examples, specifically 3 and 11). Thus, detection of expression levels of these genes individually or in combination will provide a means through which to detect preeclampsia during pregnancy. Additionally, genes that exhibit lower expression in preeclamptic tissues as compared to healthy tissues provide a means through which a patient experiencing preeclampsia may be treated therapeutically, as replacement therapy with these gene products individually or in combination may ameliorate signs or symptoms of the disease. Furthermore, genes that exhibit higher expression in preeclamptic tissues as compared to healthy tissues provide a means through which a patient experiencing preeclampsia may be treated therapeutically, as targeting of these genes in order to decrease the effect of their overexpression may ameliorate signs or symptoms of the disease.
The present invention provides a variety of diagnostic elements and compositions. One such embodiment is a diagnostic kit comprising antibody preparation that is specific for SEQ ID NO: 853-1704. The kit would be utilized to detect levels of any of the polypeptides of SEQ ID NO: 853 through 1704 that are differentially expressed in tissues derived from preeclampic patients as compared to a normal range of expression derived from healthy patients. Exemplary diagnostic antibodies include a single antibody selective for a polypeptide of the invention, a combination of 2 or more such antibodies of the invention, and a combination of at least one such antibody of the invention with an antibody that does not recognize a polypeptide of the invention. Such a kit includes a standard for any of SEQ ID NO: 853-1704 indicative of a higher risk of diagnosis of preeclampsia. Exemplary tissues subject to this diagnostic kit include serum, plasma, urine, vaginal mucous, amniotic fluid, and fetal and/or maternal cells.
Another diagnostic embodiment of the invention is a kit comprising a protein chip for quantification of levels of SEQ ID NO: 853-1704 in biological samples. Such a chip is a solid surface array with specific chemical (e.g. anion, cation, hydrophobic, hydrophilic, metal) or biochemical (e.g. antibody, receptor, DNA, enzyme) moiety precoated on the surface. The chemical moieties are designed to capture and recognize whole classes of polypeptides from a tissue sample, while the biochemical moieties are designed to capture and recognize specific polypeptide sequences.
Another diagnostic embodiment of the invention is a kit comprising one or more polynucleotide sequences of SEQ ID NO: 1-852 coupled to a surface. Polynucleotides derived from the messenger RNA (mRNA) from fetal cells or maternal tissues will be hybridized to the surface-coupled polynucleotides of any of SEQ ID NO: 1-852. The kit will be utilized to detect differentially-expressed levels of one or more of the polynucleotides of SEQ ID NO: 1-852 in fetal cells or placental tissues derived from preeclamptic patients, as compared to a normal range of expression derived from healthy patients. Such a kit includes a standard for any of SEQ ID NO: 1-852 indicative of a higher risk of diagnosis of preeclampsia. An exemplary source of fetal cells or placental tissues is from cells or tissues shed into the maternal blood, and maternal cells as well.
The present invention provides for compositions that can be utilized for replacement therapeutics in order to ameliorate the signs and symptoms of preeclampsia wherein one or more of the genes set forth in SEQ ID NO: 1-852 are down-regulated in preeclampsia. One such embodiment is a composition comprising one or more isolated polypeptides that include, but are not limited to, a polypeptide comprising the polypeptide sequence set forth in SEQ ID NO: 853-1704; or a fragment of SEQ ID NO: 853-1704. This embodiment further includes amelioration of the signs or symptoms of preeclampsia via administration of one or more of the polypeptides of SEQ ID NO: 853-1704 and a pharmaceutically acceptable carrier.
Another embodiment of the invention is a composition comprising one or more isolated polynucleotides that include, but are not limited to, a polynucleotide comprising the polynucleotide sequence set forth in SEQ ID NO: 1-852; or a fragment of SEQ ID NO: 1-852; or a full length coding sequence SEQ ID NO: 1-852. This embodiment further includes amelioration of the signs or symptoms of preeclampsia via administration of one or more of the polynucleotides of SEQ ID NO: 1-852 and a pharmaceutically acceptable vector for delivery of a functional gene corresponding to polynucleotides of SEQ ID NO: 1-852, wherein the loss of normal function of the corresponding gene has been observed through diagnostics.
The present invention provides for targeting elements and compositions for genes expressed at higher levels in preeclamptic tissues than healthy. One such embodiment is a composition comprising an antibody preparation selective for a polypeptide of SEQ ID NO: 853-1704. Exemplary therapeutic antibodies include a single such antibody of the invention, a combination of two or more such antibodies of the invention, a combination of at least one antibody of the invention with an antibody that does not recognize a polypeptide of the invention, humanized antibodies that retain all or a portion of antigen-binding sites of said antibody or complementarity-determining regions (CDR) that recognize SEQ ID NO: 853-1704, Fab antibodies or fragments thereof, including a fragment of an antibody that retains one or more CDRs that recognize SEQ ID NO: 853-1704, and antibody fusion proteins that recognize a polypeptide of the invention.
Another targeting embodiment of the invention is a vaccine comprising a polypeptide of the invention, or a fragment or variant thereof and optionally comprising a suitable adjuvant.
4. BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 shows the expression ratios of SEQ ID NO: 357 to SEQ ID NO: 551 relative to each other, using a real-time PCR protocol (TaqMan assay). The raw cycle count scores for each gene in the measured tissues were selected, with each score representing the number of doublings required to detect the message. The inverse expression ratios were computed for each gene in each measured tissue using the following formula:
- (2 raised to the power of the SEQ ID NO: 347 raw cycle count score) divided by (2 raised to the power of the SEQ ID NO: 551 raw cycle count score).
5. DETAILED DESCRIPTION OF THE INVENTION
The development of the human fetus depends on the ability of trophoblast cells to invade the maternal tissues in order to anchor the placenta and fetus to the maternal endometrium and to gain access to, and control of, the maternal circulation. Human haemochorial placentation involves proliferation, migration and invasion of the endometrium and its vasculature by trophoblast cells (extravillous trophoblast, EVT). A completion of remodeling of uteroplacental arteries, which is dependent on trophoblast invasion, appears to provide a means of unhindered placental perfusion with maternal blood. Poor placental perfusion in a hypoinvasive placenta of preeclampsia is believed to impede fetal growth and thus affect fetal well being in some cases.
The pathophysiology of preeclampsia is poorly understood. Two stages of vascular dysfunction seem to be involved. In the early stage suboptimal development of the placenta and a hemodynamic maladaptation to pregnancy exist. At this stage maternal constitutional factors such as genetic and immunological factors and preexisting vascular diseases could play a role. However, no causal relationship has yet been proven. Extracellular placental factor(s), supposedly under the influence of ischemia due to defective placentation, may be responsible for the development of the preeclampsia condition rather than preeclampsia being a simple consequence of improper placentation. Thus, these factors may cause late vascular dysfunction characterized mainly by a generalized endothelial dysfunction, thus leading to the clinical presentation of preeclampsia.
There are three distinct regions of the maternal-fetal interface, any or all of which may be involved in the clinical manifestation of preeclampsia pregnancy disorder. It has been demonstrated that there is differential gene expression of some growth factors and their receptors between these regions in normal and preeclamptic pregnancy, and thus their spatial and temporal regulation is suggested in pregnancy disorders. The compositions of the present invention are based on an anlysis of tissues from the maternal-fetal interface including 2 different areas of the placental bed: the basal plate (deciduas basalis) and marginal zone (deciduas marginalis) as well as trophoblastic villi (see Examples 1-2).
The deciduas basalis is the portion of the maternal endometrium that participates with the chorion in the formation of the placenta at the site of implantation. The invasive function of the trophoblast cells is achieved by two distinctive pathways: 1) the villous pathway, in which cytotrophoblast cells proliferate and fuse, giving rise to the syncytiotrophoblast layer of the floating villi, which is engaged primarily in exchange and endocrine functions; and 2) the extravillous pathway, in which certain cytotrophoblast cells break out of the villi as discrete cell columns, migrate and invade the decidua and its vasculature. These “extravillous trophoblast cells” (EVT) are highly proliferative and invasive. In the placental bed, these cells segregate into several subsets. Of high importance are endovascular EVTs, which replace the endothelium (maternal blood vessel lining) of the uteroplacental arteries during the process of remodeling (endovascular invasion). Poor EVT cell invasion and remodeling of uteroplacental arteries are key features of preeclampsia, whereas uncontrolled invasion is a feature of trophoblastic neoplasias including choriocarcinomas.
The decidua marginalis represents the lateral part of the placenta, responsible for the lateral placental growth.
The trophoblast villi is from the middle area of placental body represent fetal placental pathology and could provide valuable information about placental development. Moreover, the analysis of molecular pathophysiology of this region could indicate abrogated functions in pregnancy disorders.
This invention is based on the discovery that SEQ ID NO: 1-852 encode nucleotides that are either up-regulated or down-regulated in preeclamptic placenta as compared to control placenta. SEQ ID NO: 853-1704 comprise the protein or protein fragments encoded by the nucleotide sequences of SEQ ID NO: 1-852.
5.1 Definitions
It must be noted that as used herein and in the appended claims, the singular forms “a”, “an” and “the” include plural references unless the context clearly dictates otherwise.
The term “active” refers to those forms of the polypeptide that retain the biologic and/or immunologic activities of any naturally occurring polypeptide. According to the invention, the terms “biologically active” or “biological activity” refer to a protein or peptide having structural, regulatory or biochemical functions of a naturally occurring molecule. Likewise “biologically active” or “biological activity” refers to the capability of the natural, recombinant or synthetic polypeptide of the invention, or any peptide thereof, to induce a specific biological response in appropriate animals or cells and to bind with specific antibodies.
The term “activated cells” as used in this application are those cells which are engaged in extracellular or intracellular membrane trafficking, including the export of secretory or enzymatic molecules as part of a normal or disease process.
The terms “complementary” or “complementarity” refer to the natural binding of polynucleotides by base pairing. For example, the sequence 5′-AGT-3′ binds to the complementary sequence 3′-TCA-5′. Complementarity between two single-stranded molecules may be “partial” such that only some of the nucleic acids bind or it may be “complete” such that total complementarity exists between the single stranded molecules. The degree of complementarity between the nucleic acid strands has significant effects on the efficiency and strength of the hybridization between the nucleic acid strands.
The term “embryonic stem cells (ES)” refers to a cell that can give rise to many differentiated cell types in an embryo or an adult, including the germ cells. The term “germ line stem cells (GSCs)” refers to stem cells derived from primordial stem cells that provide a steady and continuous source of germ cells for the production of gametes. The term “primordial germ cells (PGCs)” refers to a small population of cells set aside from other cell lineages particularly from the yolk sac, mesenteries, or gonadal ridges during embryogenesis that have the potential to differentiate into germ cells and other cells. PGCs are the source from which GSCs and ES cells are derived The PGCs, the GSCs and the ES cells are capable of self-renewal. Thus these cells not only populate the germ line and give rise to a plurality of terminally differentiated cells that comprise the adult specialized organs, but are able to regenerate themselves. The term “totipotent” refers to the capability of a cell to differentiate into all of the cell types of an adult organism. The term “pluripotent” refers to the capability of a cell to differentiate into a number of differentiated cell types that are present in an adult organism. A pluripotent cell is restricted in its differentiation capability in comparison to a totipotent cell.
The term “expression modulating fragment,” EMF, means a series of nucleotides that modulates the expression of an operably linked ORF or another EMF. As used herein, a sequence is said to “modulate the expression of an operably linked sequence” when the expression of the sequence is altered by the presence of the EMF. EMFs include, but are not limited to, promoters, and promoter modulating sequences (inducible elements). One class of EMFs is nucleic acid fragments which induce the expression of an operably linked ORF in response to a specific regulatory factor or physiological event.
The terms “nucleotide sequence” or “nucleic acid” or “polynucleotide” or “oligonucleotide” are used interchangeably and refer to a heteropolymer of nucleotides or the sequence of these nucleotides. These phrases also refer to DNA or RNA of genomic or synthetic origin which may be single-stranded or double-stranded and may represent the sense or the antisense strand, to peptide nucleic acid (PNA) or to any DNA-like or RNA-like material. In the sequences, A is adenine, C is cytosine, G is guanine, and T is thymine, while N is A, T, G, or C. It is contemplated that where the polynucleotide is RNA, the T (thymine) in the sequence herein may be replaced with U (uracil). Generally, nucleic acid segments provided by this invention may be assembled from fragments of the genome and short oligonucleotide linkers, or from a series of oligonucleotides, or from individual nucleotides, to provide a synthetic nucleic acid which is capable of being expressed in a recombinant transcriptional unit comprising regulatory elements derived from a microbial or viral operon, or a eukaryotic gene.
The terms “oligonucleotide fragment” or a “polynucleotide fragment”, “portion,” or “segment” or “probe” or “primer” are used interchangeably and refer to a sequence of nucleotide residues which are at least about 5 nucleotides, more preferably at least about 7 nucleotides, more preferably at least about 9 nucleotides, more preferably at least about 11 nucleotides and most preferably at least about 17 nucleotides. The fragment is preferably less than about 500 nucleotides, preferably less than about 200 nucleotides, more preferably less than about 100 nucleotides, more preferably less than about 50 nucleotides and most preferably less than 30 nucleotides. Preferably the probe is from about 6 nucleotides to about 200 nucleotides, preferably from about 15 to about 50 nucleotides, more preferably from about 17 to 30 nucleotides and most preferably from about 20 to 25 nucleotides. Preferably the fragments can be used in polymerase chain reaction (PCR), various hybridization procedures or microarray procedures to identify or amplify identical or related parts of mRNA or DNA molecules. A fragment or segment may uniquely identify each polynucleotide sequence of the present invention. Preferably the fragment comprises a sequence substantially similar to a portion of SEQ ID NO: 1-852.
Probes may, for example, be used to determine whether specific mRNA molecules are present in a cell or tissue or to isolate similar nucleic acid sequences from chromosomal DNA as described by Walsh et al. (Walsh, P. S. et al., PCR Methods Appl. 1:241-250 (1992)). They may be labeled by nick translation, Klenow fill-in reaction, PCR, or other methods well known in the art. Probes of the present invention, their preparation and/or labeling are elaborated in Sambrook, J. et al., 1989, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, NY; or Ausubel, F. M. et al., 1989, Current Protocols in Molecular Biology, John Wiley & Sons, New York N.Y., both of which are incorporated herein by reference in their entirety.
The nucleic acid sequences of the present invention also include the sequence information from any of the nucleic acid sequences of SEQ ID NO: 1-852. The sequence information can be a segment of SEQ ID NO: 1-852 that uniquely identifies or represents the sequence information of SEQ ID NO: 1-852. One such segment can be a twenty-mer nucleic acid sequence because the probability that a twenty-mer is fully matched in the human genome is 1 in 300. In the human genome, there are three billion base pairs in one set of chromosomes. Because 420 possible twenty-mers exist, there are 300 times more twenty-mers than there are base pairs in a set of human chromosomes. Using the same analysis, the probability for a seventeen-mer to be fully matched in the human genome is approximately 1 in 5. When these segments are used in arrays for expression studies, fifteen-mer segments can be used. The probability that the fifteen-mer is fully matched in the expressed sequences is also approximately one in five because expressed sequences comprise less than approximately 5% of the entire genome sequence.
Similarly, when using sequence information for detecting a single mismatch, a segment can be a twenty-five mer. The probability that the twenty-five mer would appear in a human genome with a single mismatch is calculated by multiplying the probability for a full match (1÷425) times the increased probability for mismatch at each nucleotide position (3×25). The probability that an eighteen mer with a single mismatch can be detected in an array for expression studies is approximately one in five. The probability that a twenty-mer with a single mismatch can be detected in a human genome is approximately one in five.
The term “open reading frame,” ORF, means a series of nucleotide triplets coding for amino acids without any termination codons and is a sequence translatable into protein.
The terms “operably linked” or “operably associated” refer to functionally related nucleic acid sequences. For example, a promoter is operably associated or operably linked with a coding sequence if the promoter controls the transcription of the coding sequence. While operably linked nucleic acid sequences can be contiguous and in the same reading frame, certain genetic elements e.g. repressor genes are not contiguously linked to the coding sequence but still control transcription/translation of the coding sequence.
The term “pluripotent” refers to the capability of a cell to differentiate into a number of differentiated cell types that are present in an adult organism. A pluripotent cell is restricted in its differentiation capability in comparison to a totipotent cell.
The terms “polypeptide” or “peptide” or “amino acid sequence” refer to an oligopeptide, peptide, polypeptide, or protein sequence or fragment thereof and to naturally occurring or synthetic molecules. A polypeptide “fragment,” “portion,” or “segment” is a stretch of amino acid residues of at least about 5 amino acids, preferably at least about 7 amino acids, more preferably at least about 9 amino acids and most preferably at least about 17 or more amino acids. The peptide preferably is not greater than about 200 amino acids, more preferably less than 150 amino acids and most preferably less than 100 amino acids. Preferably the peptide is from about 5 to about 200 amino acids. To be active, any polypeptide must have sufficient length to display biological and/or immunological activity.
The term “naturally occurring polypeptide” refers to polypeptides produced by cells that have not been genetically engineered and specifically contemplates various polypeptides arising from post-translational modifications of the polypeptide including, but not limited to, acetylation, carboxylation, glycosylation, phosphorylation, lipidation and acylation.
The term “translated protein coding portion” means a sequence which encodes for the full length protein which may include any leader sequence or a processing sequence.
The term “mature protein coding sequence” refers to a sequence which encodes a peptide or protein without any leader/signal sequence. The “mature protein portion” refers to that portion of the protein without the leader/signal sequence. The peptide may have the leader sequences removed during processing in the cell or the protein may have been produced synthetically or using a polynucleotide only encoding for the mature protein coding sequence. It is contemplated that the mature protein portion may or may not include an initial methionine residue. The initial methionine is often removed during processing of the peptide.
The term “derivative” refers to polypeptides chemically modified by such techniques as ubiquitination, labeling (e.g., with radionuclides or various enzymes), covalent polymer attachment such as pegylation (derivatization with polyethylene glycol) and insertion or substitution by chemical synthesis of amino acids such as omithine, which do not normally occur in human proteins.
The term “variant” (or “analog”) refers to any polypeptide differing from naturally occurring polypeptides by amino acid insertions, deletions, and substitutions, created using, e.g., recombinant DNA techniques. Guidance in determining which amino acid residues may be replaced, added or deleted without abolishing activities of interest, may be found by comparing the sequence of the particular polypeptide with that of homologous peptides and minimizing the number of amino acid sequence changes made in regions of high homology (conserved regions) or by replacing amino acids with consensus sequence.
Alternatively, recombinant variants encoding these same or similar polypeptides may be synthesized or selected by making use of the “redundancy” in the genetic code. Various codon substitutions, such as the silent changes which produce various restriction sites, may be introduced to optimize cloning into a plasmid or viral vector or expression in a particular prokaryotic or eukaryotic system. Mutations in the polynucleotide sequence may be reflected in the polypeptide or domains of other peptides added to the polypeptide to modify the properties of any part of the polypeptide, to change characteristics such as ligand-binding affinities, interchain affinities, or degradation/turnover rate.
Preferably, amino acid “substitutions” are the result of replacing one amino acid with another amino acid having similar structural and/or chemical properties, i.e., conservative amino acid replacements. “Conservative” amino acid substitutions may be made on the basis of similarity in polarity, charge, solubility, hydrophobicity, hydrophilicity, and/or the amphipathic nature of the residues involved. For example, nonpolar (hydrophobic) amino acids include alanine, leucine, isoleucine, valine, proline, phenylalanine, tryptophan, and methionine; polar neutral amino acids include glycine, serine, threonine, cysteine, tyrosine, asparagine, and glutamine; positively charged (basic) amino acids include arginine, lysine, and histidine; and negatively charged (acidic) amino acids include aspartic acid and glutamic acid. “Insertions” or “deletions” are preferably in the range of about 1 to 20 amino acids, more preferably 1 to 10 amino acids. The variation allowed may be experimentally determined by systematically making insertions, deletions, or substitutions of amino acids in a polypeptide molecule using recombinant DNA techniques and assaying the resulting recombinant variants for activity.
Alternatively, where alteration of function is desired, insertions, deletions or non-conservative alterations can be engineered to produce altered polypeptides. Such alterations can, for example, alter one or more of the biological functions or biochemical characteristics of the polypeptides of the invention. For example, such alterations may change polypeptide characteristics such as ligand-binding affinities, interchain affinities, or degradation/turnover rate. Further, such alterations can be selected so as to generate polypeptides that are better suited for expression, scale up and the like in the host cells chosen for expression. For example, cysteine residues can be deleted or substituted with another amino acid residue in order to eliminate disulfide bridges.
The terms “purified” or “substantially purified” as used herein denotes that the indicated nucleic acid or polypeptide is present in the substantial absence of other biological macromolecules, e.g., polynucleotides, proteins, and the like. In one embodiment, the polynucleotide or polypeptide is purified such that it constitutes at least 95% by weight, more preferably at least 99% by weight, of the indicated biological macromolecules present (but water, buffers, and other small molecules, especially molecules having a molecular weight of less than 1000 daltons, can be present).
The term “isolated” as used herein refers to a nucleic acid or polypeptide separated from at least one other component (e.g., nucleic acid or polypeptide) present with the nucleic acid or polypeptide in its natural source. In one embodiment, the nucleic acid or polypeptide is found in the presence of (if anything) only a solvent, buffer, ion, or other components normally present in a solution of the same. The terms “isolated” and “purified” do not encompass nucleic acids or polypeptides present in their natural source.
The term “recombinant,” when used herein to refer to a polypeptide or protein, means that a polypeptide or protein is derived from recombinant (e.g., microbial, insect, or mammalian) expression systems. “Microbial” refers to recombinant polypeptides or proteins made in bacterial or fungal (e.g., yeast) expression systems. As a product, “recombinant microbial” defines a polypeptide or protein essentially free of native endogenous substances and unaccompanied by associated native glycosylation. Polypeptides or proteins expressed in most bacterial cultures, e.g., E. coli, will be free of glycosylation modifications; polypeptides or proteins expressed in yeast will have a glycosylation pattern in general different from those expressed in mammalian cells.
The term “recombinant expression vehicle or vector” refers to a plasmid or phage or virus or vector, for expressing a polypeptide from a DNA (RNA) sequence. An expression vehicle can comprise a transcriptional unit comprising an assembly of (1) a genetic element or elements having a regulatory role in gene expression, for example, promoters or enhancers, (2) a structural or coding sequence which is transcribed into mRNA and translated into protein, and (3) appropriate transcription initiation and termination sequences. Structural units intended for use in yeast or eukaryotic expression systems preferably include a leader sequence enabling extracellular secretion of translated protein by a host cell. Alternatively, where recombinant protein is expressed without a leader or transport sequence, it may include an amino terminal methionine residue. This residue may or may not be subsequently cleaved from the expressed recombinant protein to provide a final product.
The term “recombinant expression system” means host cells which have stably integrated a recombinant transcriptional unit into chromosomal DNA or carry the recombinant transcriptional unit extrachromosomally. Recombinant expression systems as defined herein will express heterologous polypeptides or proteins upon induction of the regulatory elements linked to the DNA segment or synthetic gene to be expressed. This term also means host cells which have stably integrated a recombinant genetic element or elements having a regulatory role in gene expression, for example, promoters or enhancers. Recombinant expression systems as defined herein will express polypeptides or proteins endogenous to the cell upon induction of the regulatory elements linked to the endogenous DNA segment or gene to be expressed. The cells can be prokaryotic or eukaryotic.
The term “secreted” includes a protein that is transported across or through a membrane, including transport as a result of signal sequences in its amino acid sequence when it is expressed in a suitable host cell. “Secreted” proteins include without limitation proteins secreted wholly (e.g., soluble proteins) or partially (e.g., receptors) from the cell in which they are expressed. “Secreted” proteins also include without limitation proteins that are transported across the membrane of the endoplasmic reticulum. “Secreted” proteins are also intended to include proteins containing non-typical signal sequences (e.g. Interleukin-1 Beta, see Krasney, P. A. and Young, P. R. Cytokine 4:134-143 (1992)) and factors released from damaged cells (e.g. Interleukin-1 Receptor Antagonist, see Arend, W. P. et. al. Annu. Rev. Immunol. 16:27-55 (1998)).
Where desired, an expression vector may be designed to contain a “signal or leader sequence” which will direct the polypeptide through the membrane of a cell. Such a sequence may be naturally present on the polypeptides of the present invention or provided from heterologous protein sources by recombinant DNA techniques.
The term “stringent” is used to refer to conditions that are commonly understood in the art as stringent. Stringent conditions can include highly stringent conditions (i.e., hybridization to filter-bound DNA in 0.5 M NaHPO4, 7% sodium dodecyl sulfate (SDS), 1 mM EDTA at 65° C., and washing in 0.1×SSC/0.1% SDS at 68° C.), and moderately stringent conditions (i.e., washing in 0.2×SSC/0.1% SDS at 42° C.). Other exemplary hybridization conditions are described herein in the examples.
In instances of hybridization of deoxyoligonucleotides, additional exemplary stringent hybridization conditions include washing in 6×SSC/0.05% sodium pyrophosphate at 37° C. (for 14-base oligonucleotides), 48° C. (for 17-base oligonucleotides), 55° C. (for 20-base oligonucleotides), and 60° C. (for 23-base oligonucleotides).
As used herein, “substantially equivalent” can refer both to nucleotide and amino acid sequences, for example a mutant sequence, that varies from a reference sequence by one or more substitutions, deletions, or additions, the net effect of which does not result in an adverse functional dissimilarity between the reference and subject sequences. Typically, such a substantially equivalent sequence varies from one of those listed herein by no more than about 35% (i.e., the number of individual residue substitutions, additions, and/or deletions in a substantially equivalent sequence, as compared to the corresponding reference sequence, divided by the total number of residues in the substantially equivalent sequence is about 0.35 or less). Such a sequence is said to have 65% sequence identity to the listed sequence. In one embodiment, a substantially equivalent, e.g., mutant, sequence of the invention varies from a listed sequence by no more than 30% (70% sequence identity); in a variation of this embodiment, by no more than 25% (75% sequence identity); and in a further variation of this embodiment, by no more than 20% (80% sequence identity) and in a further variation of this embodiment, by no more than 10% (90% sequence identity) and in a further variation of this embodiment, by no more that 5% (95% sequence identity). Substantially equivalent, e.g., mutant, amino acid sequences according to the invention preferably have at least 80% sequence identity with a listed amino acid sequence, more preferably at least 90% sequence identity. Substantially equivalent nucleotide sequence of the invention can have lower percent sequence identities, taking into account, for example, the redundancy or degeneracy of the genetic code. Preferably, nucleotide sequence has at least about 65% identity, more preferably at least about 75% identity, and most preferably at least about 95% identity. For the purposes of the present invention, sequences having substantially equivalent biological activity and substantially equivalent expression characteristics are considered substantially equivalent. For the purposes of determining equivalence, truncation of the mature sequence (e.g., via a mutation which creates a spurious stop codon) should be disregarded. Sequence identity may be determined, e.g., using the Jotun Hein method (Hein, J. Methods Enzymol. 183:626-645 (1990)). Identity between sequences can also be determined by other methods known in the art, e.g. by varying hybridization conditions.
The term “totipotent” refers to the capability of a cell to differentiate into all of the cell types of an adult organism.
The term “transformation” means introducing DNA into a suitable host cell so that the DNA is replicable, either as an extrachromosomal element, or by chromosomal integration. The term “transfection” refers to the taking up of an expression vector by a suitable host cell, whether or not any coding sequences are in fact expressed. The term “infection” refers to the introduction of nucleic acids into a suitable host cell by use of a virus or viral vector.
As used herein, an “uptake modulating fragment,” UMF, means a series of nucleotides which mediate the uptake of a linked DNA fragment into a cell. UMFs can be readily identified using known UMFs as a target sequence or target motif with the computer-based systems described below. The presence and activity of a UMF can be confirmed by attaching the suspected UMF to a marker sequence. The resulting nucleic acid molecule is then incubated with an appropriate host under appropriate conditions and the uptake of the marker sequence is determined. As described above, a UMF will increase the frequency of uptake of a linked marker sequence.
Each of the above terms is meant to encompass all that is described for each, unless the context dictates otherwise.
5.2 Nucleic Acids of the Invention
The invention is based on the discovery of differentially-expressed polynucleotides in preeclamptic versus normal placental tissues, the polynucleotides encoding corresponding polypeptides and the use of these compositions for the diagnosis, treatment or prevention of preeclampsia.
The isolated polynucleotides of the invention include, but are not limited to a polynucleotide comprising any of the nucleotide sequences of SEQ ID NO: 1-852; a fragment of SEQ ID NO: 1-852; a polynucleotide comprising the full length protein coding sequence of SEQ ID NO: 1-852 (for example coding for SEQ ID NO: 853 through 1704); and a polynucleotide comprising the nucleotide sequence encoding the mature protein coding sequence of the polypeptides of any one of SEQ ID NO: 853-1704. The polynucleotides of the present invention also include, but are not limited to, a polynucleotide that hybridizes under stringent conditions to (a) the complement of any of the nucleotides sequences of SEQ ID NO: 1-852; (b) a polynucleotide encoding any one of the polypeptides of SEQ ID NO: 853-1704; (c) a polynucleotide which is an allelic variant of any polynucleotides recited above; (d) a polynucleotide which encodes a species homolog of any of the proteins recited above; or (e) a polynucleotide that encodes a polypeptide comprising a specific domain or truncation of the polypeptides of SEQ ID NO: 853-1704. Domains of interest may depend on the nature of the encoded polypeptide; e.g., domains in receptor-like polypeptides include ligand-binding, extracellular, transmembrane, or cytoplasmic domains, or combinations thereof; domains in immunoglobulin-like proteins include the variable immunoglobulin-like domains; domains in enzyme-like polypeptides include catalytic and substrate binding domains; and domains in ligand polypeptides include receptor-binding domains.
The polynucleotides of the invention include naturally occurring or wholly or partially synthetic DNA, e.g., cDNA and genomic DNA, and RNA, e.g., mRNA. The polynucleotides may include all of the coding region of the cDNA or may represent a portion of the coding region of the cDNA.
The present invention also provides genes corresponding to the cDNA sequences disclosed herein. The corresponding genes can be isolated in accordance with known methods using the sequence information disclosed herein. Such methods include the preparation of probes or primers from the disclosed sequence information for identification and/or amplification of genes in appropriate genomic libraries or other sources of genomic materials. Further 5′ and 3′ sequence can be obtained using methods known in the art. For example, full length cDNA or genomic DNA that corresponds to any of the polynucleotides of SEQ ID NO: 1-852 can be obtained by screening appropriate cDNA or genomic DNA libraries under suitable hybridization conditions using any of the polynucleotides of SEQ ID NO: 1-852 or a portion thereof as a probe. Alternatively, the polynucleotides of SEQ ID NO: 1-852 may be used as the basis for suitable primer(s) that allow identification and/or amplification of genes in appropriate genomic DNA or cDNA libraries.
The nucleic acid sequences of the invention can be assembled from ESTs and sequences (including cDNA and genomic sequences) obtained from one or more public databases, such as dbEST, gbpri, and UniGene. The EST sequences can provide identifying sequence information, representative fragment or segment information, or novel segment information for the full-length gene.
The polynucleotides of the invention also provide polynucleotides including nucleotide sequences that are substantially equivalent to the polynucleotides recited above. Polynucleotides according to the invention can have, e.g., at least about 65%, at least about 70%, at least about 75%, at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, or 89%, more typically at least about 90%, 91%, 92%, 93%, or 94% and even more typically at least about 95%, 96%, 97%, 98% or 99% sequence identity to a polynucleotide recited above.
Included within the scope of the nucleic acid sequences of the invention are nucleic acid sequence fragments that hybridize under stringent conditions to any of the nucleotide sequences of SEQ ID NO: 1-852, or complements thereof, which fragment is greater than about 5 nucleotides, preferably 7 nucleotides, more preferably greater than 9 nucleotides and most preferably greater than 17 nucleotides. Fragments of, e.g. 15, 17, or 20 nucleotides or more that are selective for (i.e. specifically hybridize to any one of the polynucleotides of the invention) are contemplated. Probes capable of specifically hybridizing to a polynucleotide can differentiate polynucleotide sequences of the invention from other polynucleotide sequences in the same family of genes or can differentiate human genes from genes of other species, and are preferably based on unique nucleotide sequences.
The sequences falling within the scope of the present invention are not limited to these specific sequences, but also include allelic and species variations thereof. Allelic and species variations can be routinely determined by comparing the sequence provided in SEQ ID NO: 1-852, a representative fragment thereof, or a nucleotide sequence at least 90% identical, preferably 95% identical, to SEQ ID NO: 1-852 with a sequence from another isolate of the same species. Furthermore, to accommodate codon variability, the invention includes nucleic acid molecules coding for the same amino acid sequences as do the specific ORFs disclosed herein. In other words, in the coding region of an ORF, substitution of one codon for another codon that encodes the same amino acid is expressly contemplated.
The nearest neighbor result for the nucleic acids or polypeptides of the present invention, including SEQ ID NO: 1-852, and SEQ ID NO: 853-1704 can be obtained by searching a database using an algorithm or a program. Preferably, a BLAST which stands for Basic Local Alignment Search Tool is used to search for local sequence alignments (Altshul, S. F. J. Mol. Evol. 36 290-300 (1993) and Altschul S. F. et al. J. Mol. Biol. 21:403-410 (1990)).
Species homologs (or orthologs) of the disclosed polynucleotides and proteins are also provided by the present invention. Species homologs may be isolated and identified by making suitable probes or primers from the sequences provided herein and screening a suitable nucleic acid source from the desired species.
The invention also encompasses allelic variants of the disclosed polynucleotides or proteins; that is, naturally occurring alternative forms of the isolated polynucleotide that also encode proteins which are identical, homologous or related to that encoded by the polynucleotides.
The nucleic acid sequences of the invention are further directed to sequences which encode variants of the described nucleic acids. These amino acid sequence variants may be prepared by methods known in the art by introducing appropriate nucleotide changes into a native or variant polynucleotide. There are two variables in the construction of amino acid sequence variants: the location of the mutation and the nature of the mutation. Nucleic acids encoding the amino acid sequence variants are preferably constructed by mutating the polynucleotide to encode an amino acid sequence that does not occur in nature. These nucleic acid alterations can be made at sites that differ in the nucleic acids from different species (variable positions) or in highly conserved regions (constant regions). Sites at such locations will typically be modified in series, e.g., by substituting first with conservative choices (e.g., hydrophobic amino acid to a different hydrophobic amino acid) and then with more distant choices (e.g., hydrophobic amino acid to a charged amino acid), and then deletions or insertions may be made at the target site. Amino acid sequence deletions generally range from about 1 to 30 residues, preferably about 1 to 10 residues, and are typically contiguous. Amino acid insertions include amino- and/or carboxyl-terminal fusions ranging in length from one to one hundred or more residues, as well as intrasequence insertions of single or multiple amino acid residues. Intrasequence insertions may range generally from about 1 to 10 amino residues, preferably from 1 to 5 residues. Examples of terminal insertions include the heterologous signal sequences necessary for secretion or for intracellular targeting in different host cells and sequences such as FLAG or poly-histidine sequences useful for purifying the expressed protein.
In a preferred method, polynucleotides encoding the novel amino acid sequences are changed via site-directed mutagenesis. This method uses oligonucleotide sequences to alter a polynucleotide to encode the desired amino acid variant, as well as sufficient adjacent nucleotides on both sides of the changed amino acid to form a stable duplex on either side of the site being changed. In general, the techniques of site-directed mutagenesis are well known to those of skill in the art and this technique is exemplified by publications such as, Edelman et al., DNA 2:183 (1983). A versatile and efficient method for producing site-specific changes in a polynucleotide sequence was published by Zoller and Smith, Nucleic Acids Res. 10:6487-6500 (1982). PCR may also be used to create amino acid sequence variants of the novel nucleic acids. When small amounts of template DNA are used as starting material, primer(s) that differs slightly in sequence from the corresponding region in the template DNA can generate the desired amino acid variant. PCR amplification results in a population of product DNA fragments that differ from the polynucleotide template encoding the polypeptide at the position specified by the primer. The product DNA fragments replace the corresponding region in the plasmid and this gives a polynucleotide encoding the desired amino acid variant.
A further technique for generating amino acid variants is the cassette mutagenesis technique described in Wells et al., Gene 34:315 (1985); and other mutagenesis techniques well known in the art, such as, for example, the techniques in Sambrook, et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, NY (1989), and Current Protocols in Molecular Biology, Ausubel et al. Due to the inherent degeneracy of the genetic code, other DNA sequences which encode substantially the same or a functionally equivalent amino acid sequence may be used in the practice of the invention for the cloning and expression of these novel nucleic acids. Such DNA sequences include those that are capable of hybridizing to the appropriate novel nucleic acid sequence under stringent conditions.
Polynucleotides encoding preferred polypeptide truncations of the invention can be used to generate polynucleotides encoding chimeric or fusion proteins comprising one or more domains of the invention and heterologous protein sequences.
The polynucleotides of the invention additionally include the complement of any of the polynucleotides recited above. The polynucleotide can be DNA (genomic, cDNA, amplified, or synthetic) or RNA. Methods and algorithms for obtaining such polynucleotides are well known to those of skill in the art and can include, for example, methods for determining hybridization conditions that can routinely isolate polynucleotides of the desired sequence identities.
In accordance with the invention, polynucleotide sequences comprising the mature protein coding sequences, coding for any one of SEQ ID NO: 853-1704, or functional equivalents thereof, may be used to generate recombinant DNA molecules that direct the expression of that nucleic acid, or a functional equivalent thereof, in appropriate host cells. Also included are the cDNA inserts of any of the clones identified herein.
A polynucleotide according to the invention can be joined to any of a variety of other nucleotide sequences by well-established recombinant DNA techniques (see Sambrook J et al. (1989) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, NY). Useful nucleotide sequences for joining to polynucleotides include an assortment of vectors, e.g., plasmids, cosmids, lambda phage derivatives, phagemids, and the like, that are well known in the art. Accordingly, the invention also provides a vector including a polynucleotide of the invention and a host cell containing the polynucleotide. In general, the vector contains an origin of replication functional in at least one organism, convenient restriction endonuclease sites, and a selectable marker for the host cell. Vectors according to the invention include expression vectors, replication vectors, probe generation vectors, and sequencing vectors. A host cell according to the invention can be a prokaryotic or eukaryotic cell and can be a unicellular organism or part of a multicellular organism.
The present invention further provides recombinant constructs comprising a nucleic acid having any of the nucleotide sequences of SEQ ID NO: 1-852 or a fragment thereof or any other polynucleotides of the invention. In one embodiment, the recombinant constructs of the present invention comprise a vector, such as a plasmid or viral vector, into which a nucleic acid having any of the nucleotide sequences of SEQ ID NO: 1-852 or a fragment thereof is inserted, in a forward or reverse orientation. In the case of a vector comprising one of the ORFs of the present invention, the vector may further comprise regulatory sequences, including for example, a promoter, operably linked to the ORF. Large numbers of suitable vectors and promoters are known to those of skill in the art and are commercially available for generating the recombinant constructs of the present invention. The following vectors are provided by way of example. Bacterial: pBs, phagescript, PsiX174, pBluescript SK, pBs KS, pNH8a, pNH16a, pNH18a, pNH46a (Stratagene); pTrc99A, pKK223-3, pKK233-3, pDR540, pRIT5 (Pharmacia). Eukaryotic: pWLneo, pSV2cat, pOG44, PXTI, pSG (Stratagene) pSVK3, pBPV, pMSG, and pSVL (Pharmacia/Pfizer).
The isolated polynucleotide of the invention may be operably linked to an expression control sequence such as the pMT2 or pED expression vectors disclosed in Kaufinan et al., Nucleic Acids Res. 19, 4485-4490 (1991), in order to produce the protein recombinantly. Many suitable expression control sequences are known in the art. General methods of expressing recombinant proteins are also known and are exemplified in R. Kaufman, Methods in Enzymology 185, 537-566 (1990). As defined herein “operably linked” means that the isolated polynucleotide of the invention and an expression control sequence are situated within a vector or cell in such a way that the protein is expressed by a host cell which has been transformed (transfected) with the ligated polynucleotide/expression control sequence.
Promoter regions can be selected from any desired gene using CAT (chloramphenicol transferase) vectors or other vectors with selectable markers. Two appropriate vectors are pKK232-8 and pCM7. Particular named bacterial promoters include lacd, lacZ, T3, T7, gpt, lambda PR, and trc. Eukaryotic promoters include CMV immediate early, HSV thymidine kinase, early and late SV40, LTRs from retrovirus, and mouse metallothionein-I. Selection of the appropriate vector and promoter is well within the level of ordinary skill in the art. Generally, recombinant expression vectors will include origins of replication and selectable markers permitting transformation of the host cell, e.g., the ampicillin resistance gene of E. coli and S. cerevisiae TRP1 gene, and a promoter derived from a highly expressed gene to direct transcription of a downstream structural sequence. Such promoters can be derived from operons encoding glycolytic enzymes such as 3-phosphoglycerate kinase (PGK), a-factor, acid phosphatase, or heat shock proteins, among others. The heterologous structural sequence is assembled in appropriate phase with translation initiation and termination sequences, and preferably, a leader sequence capable of directing secretion of translated protein into the periplasmic space or extracellular medium. Optionally, the heterologous sequence can encode a fusion protein including an amino terminal identification peptide imparting desired characteristics, e.g., stabilization or simplified purification of expressed recombinant product. Useful expression vectors for bacterial use are constructed by inserting a structural DNA sequence encoding a desired protein together with suitable translation initiation and termination signals in operable reading phase with a functional promoter. The vector will comprise one or more phenotypic selectable markers and an origin of replication to ensure maintenance of the vector and to, if desirable, provide amplification within the host. Suitable prokaryotic hosts for transformation include E. coli, Bacillus subtilis, Salmonella typhimurium and various species within the genera Pseudomonas, Streptomyces, and Staphylococcus, although others may also be employed as a matter of choice.
As a representative but non-limiting example, useful expression vectors for bacterial use can comprise a selectable marker and bacterial origin of replication derived from commercially available plasmids comprising genetic elements of the well known cloning vector pBR322 (ATCC 37017). Such commercial vectors include, for example, pKK223-3 (Pharmacia Fine Chemicals, Uppsala, Sweden) and GEM 1 (Promega Biotech, Madison, Wis., USA). These pBR322 “backbone” sections are combined with an appropriate promoter and the structural sequence to be expressed. Following transformation of a suitable host strain and growth of the host strain to an appropriate cell density, the selected promoter is induced or derepressed by appropriate means (e.g., temperature shift or chemical induction) and cells are cultured for an additional period. Cells are typically harvested by centrifugation, disrupted by physical or chemical means, and the resulting crude extract retained for further purification.
Polynucleotides of the invention can also be used to induce immune responses. For example, as described in Fan et al., Nat. Biotech. 17:870-872 (1999), hereby incorporated herein by reference, nucleic acid sequences encoding a polypeptide may be used to generate antibodies against the encoded polypeptide following topical administration of naked plasmid DNA or following injection, and preferably intramuscular injection of the DNA. The nucleic acid sequences are preferably inserted in a recombinant expression vector and may be in the form of naked DNA.
Another aspect of the invention pertains to isolated antisense nucleic acid molecules that can hybridize to, or are complementary to, the nucleic acid molecules comprising SEQ ID NO: 1-852, or fragments, analogs or derivatives thereof. An “antisense” nucleic acid comprises a nucleotide sequence that is complementary to a “sense” nucleic acid encoding a protein (e.g., complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence). In specific aspects, antisense nucleic acid molecules are provided that comprise a sequence complementary to at least about 10, 25, 50, 100, 250 or 500 nucleotides or an entire coding strand of SEQ ID NO: 1-852, or to only a portion thereof. Nucleic acid molecules encoding fragments, homologs, derivatives and analogs of SEQ ID NO: 1-852 or antisense nucleic acids complementary to SEQ ID NO: 1-852 nucleic acid sequences of are additionally provided.
In one embodiment, an antisense nucleic acid molecule is antisense to a “coding region” of the coding strand of a nucleotide sequence encoding like protein of any of SEQ ID NO: 1-852. The term “coding region” refers to the region of the nucleotide sequence comprising codons that are translated into amino acid residues. In another embodiment, the antisense nucleic acid molecule is antisense to a “conceding region” of the coding strand of a nucleotide sequence encoding the proteins of SEQ ID NO: 853-1704. The term “conceding region” refers to 5′ and 3′ sequences which flank the coding region that are not translated into amino acids (i.e., also referred to as 5′ and 3′ untranslated regions).
Given the coding strand sequences encoding the polypeptides of SEQ ID NO: 853-1704 disclosed herein, antisense nucleic acids of the invention can be designed according to the rules of Watson and Crick or Hoogsteen base pairing. The antisense nucleic acid molecule can be complementary to the entire coding region of SEQ ID NO: 1-852-like mRNA, but more preferably is an oligonucleotide that is antisense to only a portion of the coding or noncoding region of said mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of SEQ ID NO: 1-852-like mRNA. An antisense oligonucleotide can be, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45, or 50 nucleotides in length. An antisense nucleic acid of the invention can be constructed using chemical synthesis or enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleic acid (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids (e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used).
Examples of modified nucleotides that can be used to generate the antisense nucleic acid include: 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5′-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N-6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, and 2,6-diaminopurine. Alternatively, the antisense nucleic acid can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following section).
The antisense nucleic acid molecules of the invention are typically administered to a subject or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding a polynucleotide or polypeptide of the invention to thereby inhibit expression of the protein (e.g., by inhibiting transcription and/or translation). The hybridization can be by conventional nucleotide complementarity to form a stable duplex, or, for example, in the case of an antisense nucleic acid molecule that binds to DNA duplexes, through specific interactions in the major groove of the double helix. An example of a route of administration of antisense nucleic acid molecules of the invention includes direct injection at a tissue site. Alternatively, antisense nucleic acid molecules can be modified to target selected cells and then administered systemically. For example, for systemic administration, antisense molecules can be modified such that they specifically bind to receptors or antigens expressed on a selected cell surface (e.g., by linking the antisense nucleic acid molecules to peptides or antibodies that bind to cell surface receptors or antigens). The antisense nucleic acid molecules can also be delivered to cells using the vectors described herein. To achieve sufficient nucleic acid molecules, vector constructs in which the antisense nucleic acid molecule is placed under the control of a strong pol II or pol III promoter are preferred.
In yet another embodiment, the antisense nucleic acid molecule of the invention is an alpha-anomeric nucleic acid molecule. An alpha-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual alpha-units, the strands run parallel to each other. See, e.g., Gaultier, et al., 1987. Nucl. Acids Res. 15: 6625-6641. The antisense nucleic acid molecule can also comprise a 2′-o-methylribonucleotide (see, e.g., Inoue, et al. 1987. Nucl. Acids Res. 15: 6131-6148) or a chimeric RNA-DNA analogue (see, e.g., Inoue, et al., 1987. FEBS Lett. 215: 327-330.
Nucleic acid modifications include, by way of non-limiting example, modified bases, and nucleic acids whose sugar phosphate backbones are modified or derivatized. These modifications are carried out at least in part to enhance the chemical stability of the modified nucleic acid, such that they can be used, for example, as antisense binding nucleic acids in therapeutic applications in a subject.
In one embodiment, an antisense nucleic acid of the invention is a ribozyme. Ribozymes are catalytic RNA molecules with ribonuclease activity that are capable of cleaving a single-stranded nucleic acid, such as an mRNA, to which they have a complementary region. Thus, ribozymes (e.g., hammerhead ribozymes as described in Haselhoff and Gerlach 1988. Nature 334: 585-591) can be used to catalytically cleave mRNA transcripts corresponding to SEQ ID NO: 1-852 to thereby inhibit translation of said mRNA. A ribozyme having specificity for SEQ ID NO: 1-852-like-encoding nucleic acid can be designed based upon the nucleotide sequence of a corresponding cDNA disclosed herein. For example, a derivative of a Tetrahymena L-19 IVS RNA can be constructed in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in SEQ ID NO: 1-852-like encoding mRNA. See, e.g., U.S. Pat. No. 4,987,071 to Cech, et al. and U.S. Pat. No. 5,116,742 to Cech, et al. mRNA corresponding to SEQ ID NO: 1-852 can also be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules. See, e.g., Bartel et al., (1993) Science 261:1411-1418.
Alternatively, SEQ ID NO: 1-852 gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region of the said nucleic acids (e.g., the promoter and/or enhancers of each gene corresponding to the polynucleotide of the invention) to form triple helical structures that prevent transcription of the genes in target cells. See, e.g., Helene, 1991. Anticancer Drug Des. 6: 569-84; Helene, et al. 1992. Ann. N.Y. Acad. Sci. 660: 27-36; Maher, 1992. Bioassays 14: 807-15.
In various embodiments, the nucleic acids of the invention can be modified at the base moiety, sugar moiety or phosphate backbone to improve, e.g., the stability, hybridization, or solubility of the molecule. For example, the deoxyribose phosphate backbone of the nucleic acids can be modified to generate peptide nucleic acids. See, e.g., Hyrup, et al., 1996. Bioorg Med Chem 4: 5-23. As used herein, the terms “peptide nucleic acids” or “PNAs” refer to nucleic acid mimics (e.g., DNA mimics) in which the deoxyribose phosphate backbone is replaced by a pseudopeptide backbone and only the four natural nucleobases are retained. The neutral backbone of PNAs has been shown to allow for specific hybridization to DNA and RNA under conditions of low ionic strength. The synthesis of PNA oligomers can be performed using standard solid phase peptide synthesis protocols as described in Hyrup, et al., 1996. supra; Perry-O'Keefe, et al., 1996. Proc. Natl. Acad. Sci. USA 93: 14670-14675.
PNAs of the nucleic acids of the invention can be used in therapeutic and diagnostic applications. For example, PNAs can be used as antisense or antigene agents for sequence-specific modulation of gene expression by, e.g., inducing transcription or translation arrest or inhibiting replication. PNAs of the nucleic acids of the invention can also be used, for example, in the analysis of single base pair mutations in a gene (e.g., PNA directed PCR clamping; as artificial restriction enzymes when used in combination with other enzymes, e.g., S1 nucleases (see, Hyrup, et al., 1996.supra); or as probes or primers for DNA sequence and hybridization (see, Hyrup, et al., 1996, supra; Perry-O'Keefe, et al., 1996. supra).
In another embodiment, PNAs of nucleic acids of the invention can be modified, e.g., to enhance their stability or cellular uptake, by attaching lipophilic or other helper groups to PNA, by the formation of PNA-DNA chimeras, or by the use of liposomes or other techniques of drug delivery known in the art. For example, PNA-DNA chimeras of the nucleic acids of the invention can be generated that may combine the advantageous properties of PNA and DNA. Such chimeras allow DNA recognition enzymes (e.g., RNase H and DNA polymerases) to interact with the DNA portion while the PNA portion would provide high binding affinity and specificity. PNA-DNA chimeras can be linked using linkers of appropriate lengths selected in terms of base stacking, number of bonds between the nucleobases, and orientation (see, Hyrup, et al., 1996. supra). The synthesis of PNA-DNA chimeras can be performed as described in Hyrup, et al., 1996. Supra, et al., 1996. Nucl Acids Res 24: 3357-3363. For example, a DNA chain can be synthesized on a solid support using standard phosphoramidite coupling chemistry, and modified nucleoside analogs, e.g., 5′-(4-methoxytrityl)amino-5′-deoxy-thymidine phosphoramidite, can be used between the PNA and the 5′ end of DNA. See, e.g., Mag, et al., 1989. Nucl Acid Res 17: 5973-5988. PNA monomers are then coupled in a stepwise manner to produce a chimeric molecule with a 5′ PNA segment and a 3′ DNA segment. See, e.g., Finn, et al., 1996. supra. Alternatively, chimeric molecules can be synthesized with a 5′ DNA segment and a 3′ PNA segment. See, e.g., Petersen, et al., 1975. Bioorg. Med. Chem. Lett. 5: 1119-11124.
In other embodiments, the oligonucleotide may include other appended groups such as peptides (e.g., for targeting host cell receptors in vivo), or agents facilitating transport across the cell membrane (see, e.g., Letsinger, et al., 1989. Proc. Natl. Acad. Sci. U.S.A. 86: 6553-6556; Lemaitre, et al., 1987. Proc. Natl. Acad. Sci. 84: 648-652; PCT Publication No. WO88/09810) or the blood-brain barrier (see, e.g., PCT Publication No. WO 89/10134). In addition, oligonucleotides can be modified with hybridization-triggered cleavage agents (see, e.g., Krol, et al., 1988. BioTechniques 6:958-976) or intercalating agents (see, e.g., Zon, 1988. Pharm. Res. 5: 539-549). To this end, the oligonucleotide can be conjugated to another molecule, e.g., a peptide, a hybridization triggered cross-linking agent, a transport agent, a hybridization-triggered cleavage agent, and the like.
5.3 Use of Nucleic Acids as Probes
Another aspect of the subject invention is to provide for polypeptide-specific nucleic acid hybridization probes capable of hybridizing with naturally occurring nucleotide sequences. The hybridization probes of the subject invention may be derived from any of the nucleotide sequences SEQ ID NO: 1-852. Because the corresponding gene is only expressed in a limited number of tissues, a hybridization probe derived from of any of the nucleotide sequences SEQ ID NO: 1-852 can be used as an indicator of the presence of RNA of cell type of such a tissue in a sample.
Any suitable hybridization technique can be employed, such as, for example, in situ hybridization. PCR as described in U.S. Pat. Nos. 4,683,195 and 4,965,188 provides additional uses for oligonucleotides based upon the nucleotide sequences. Such probes used in PCR may be of recombinant origin, may be chemically synthesized, or a mixture of both. The probe will comprise a discrete nucleotide sequence for the detection of identical sequences or a degenerate pool of possible sequences for identification of closely related genomic sequences.
Other means for producing specific hybridization probes for nucleic acids include the cloning of nucleic acid sequences into vectors for the production of mRNA probes. Such vectors are known in the art and are commercially available and may be used to synthesize RNA probes in vitro by means of the addition of the appropriate RNA polymerase as T7 or SP6 RNA polymerase and the appropriate radioactively labeled nucleotides. The nucleotide sequences may be used to construct hybridization probes for mapping their respective genomic sequences. The nucleotide sequence provided herein may be mapped to a chromosome or specific regions of a chromosome using well known genetic and/or chromosomal mapping techniques. These techniques include in situ hybridization, linkage analysis against known chromosomal markers, hybridization screening with libraries or flow-sorted chromosomal preparations specific to known chromosomes, and the like. The technique of fluorescent in situ hybridization of chromosome spreads has been described, among other places, in Verma et al (1988) Human Chromosomes: A Manual of Basic Techniques, Pergamon Press, New York N.Y.
Fluorescent in situ hybridization of chromosomal preparations and other physical chromosome mapping techniques may be correlated with additional genetic map data. Examples of genetic map data can be found in the 1994 Genome Issue of Science (265:1981f). Correlation between the location of a nucleic acid on a physical chromosomal map and a specific disease (or predisposition to a specific disease) may help delimit the region of DNA associated with that genetic disease. The nucleotide sequences of the subject invention may be used to detect differences in gene sequences between normal, carrier or affected individuals.
5.4 Preparation of Support Bound Oligonucleotides
Oligonucleotides, i.e., small nucleic acid segments, may be readily prepared by, for example, directly synthesizing the oligonucleotide by chemical means, as is commonly practiced using an automated oligonucleotide synthesizer.
Support bound oligonucleotides may be prepared by any of the methods known to those of skill in the art using any suitable support such as glass, polystyrene or Teflon. One strategy is to precisely spot oligonucleotides synthesized by standard synthesizers. Immobilization can be achieved using passive adsorption (Inouye & Hondo, 1990 J. Clin Microbiol 28(6) 1462-72); using UV light (Nagata et al., 1985; Dahlen et al., 1987; Morrissey & Collins, Mol. Cell Probes 1989 3(2) 189-207) or by covalent binding of base modified DNA (Keller et al., 1988; 1989); all references being specifically incorporated herein.
Another strategy that may be employed is the use of the strong biotin-streptavidin interaction as a linker. For example, Broude et al. (1994) Proc. Natl. Acad. Sci USA 91(8) 3072-6 describe the use of biotinylated probes, although these are duplex probes, that are immobilized on streptavidin-coated magnetic beads. Streptavidin-coated beads may be purchased from Dynal, Oslo. Of course, this same linking chemistry is applicable to coating any surface with streptavidin. Biotinylated probes may be purchased from various sources, such as, e.g., Operon Technologies (Alameda, Calif.).
Alternatively, DNA may be covalently bound to the microwell surface using Covalink NH technology (Nunc Laboratories, Naperville, Ill.). CovaLink NH is a polystyrene surface grafted with secondary amino groups (>NH) that serve as bridge-heads for further covalent coupling. CovaLink Modules may be purchased from Nunc Laboratories. DNA molecules may be bound to CovaLink exclusively at the 5′-end by a phosphoramidate bond, allowing immobilization of more than 1 pmol of DNA (Rasmussen et al., (1991) Anal Biochem 198(1) 138-42.
The use of CovaLink NH strips for covalent binding of DNA molecules at the 5′-end has been described (Rasmussen et al., 1991, Ann Biol Clin (Paris). 1990;48(9):647-50). In this technology, a phosphoramidate bond is employed (Chu et al., 1983 Nucleic Acids 11(18) 6513-29). This is beneficial as immobilization using only a single covalent bond is preferred. The phosphoramidate bond joins the DNA to the CovaLink NH secondary amino groups that are positioned at the end of spacer arms covalently grafted onto the polystyrene surface through a 2 nm long spacer arm. To link an oligonucleotide to Covaink NH via an phosphoramidate bond, the oligonucleotide terminus must have a 5′-end phosphate group. It is, perhaps, even possible for biotin to be covalently bound to CovaLink and then streptavidin used to bind the probes.
More specifically, the linkage method includes dissolving DNA in water (7.5 ng/ul) and denaturing for 10 min. at 95° C. and cooling on ice for 10 min. Ice-cold 0.1 M 1-methylimidazole, pH 7.0 (1-MeIm7), is then added to a final concentration of 10 mM 1-MeIm7. A single stranded DNA solution is then dispensed into CovaLink NH strips (75 ul/well) standing on ice.
Carbodiimide 0.2 M 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC), dissolved in 10 mM 1-MeIm7, is made fresh and 25 ul added per well. The strips are incubated for 5 hours at 50° C. After incubation the strips are washed using, e.g., Nunc-Immuno Wash; first the wells are washed 3 times, then they are soaked with washing solution for 5 min., and finally they are washed 3 times (where in the washing solution is 0.4 N NaOH, 0.25% SDS heated to 50° C.).
It is contemplated that a further suitable method for use with the present invention is that described in PCT Patent Application WO 90/03382 (Southern & Maskos), hereby incorporated herein by reference. This method of preparing an oligonucleotide bound to a support involves attaching a nucleoside 3′-reagent through the phosphate group by a covalent phosphodiester link to aliphatic hydroxyl groups carried by the support. The oligonucleotide is then synthesized on the supported nucleoside and protecting groups removed from the synthetic oligonucleotide chain under standard conditions that do not cleave the oligonucleotide from the support. Suitable reagents include nucleoside phosphoramidite and nucleoside hydrogen phosphorate.
An on-chip strategy for the preparation of DNA probe for the preparation of DNA probe arrays may be employed. For example, addressable laser-activated photodeprotection may be employed in the chemical synthesis of oligonucleotides directly on a glass surface, as described by Fodor et al. (1991) Science 251(4995) 767-73, hereby incorporated herein by reference. Probes may also be immobilized on nylon supports as described by Van Ness et al. (1991) Nucleic Acids Res. 19(12) 3345-50; or linked to Teflon using the method of Duncan & Cavalier (1988) Anal Biochem 169(1) 104-8; all references being specifically incorporated herein.
To link an oligonucleotide to a nylon support, as described by Van Ness et al. (1991), requires activation of the nylon surface via alkylation and selective activation of the 5′-amine of oligonucleotides with cyanuric chloride.
One particular way to prepare support bound oligonucleotides is to utilize the light-generated synthesis described by Pease et al., (1994) Proc. Natl. Acad. Sci USA 91(11) 5022-6. These authors used current photolithographic techniques to generate arrays of immobilized oligonucleotide probes (DNA chips). These methods, in which light is used to direct the synthesis of oligonucleotide probes in high-density, miniaturized arrays, utilize photolabile 5′-protected N-acyl-deoxynucleoside phosphoramidites, surface linker chemistry and versatile combinatorial synthesis strategies. A matrix of 256 spatially defined oligonucleotide probes may be generated in this manner.
5.5 Preparation of Nucleic Acid Fragments
The nucleic acids may be obtained from any appropriate source, such as cDNAs, genomic DNA, chromosomal DNA, microdissected chromosome bands, cosmid or YAC inserts, and RNA, including mRNA without any amplification steps. For example, Sambrook et al. (1989) describes three protocols for the isolation of high molecular weight DNA from mammalian cells (p. 9.14-9.23).
DNA fragments may be prepared as clones in M13, plasmid or lambda vectors and/or prepared directly from genomic DNA or cDNA by PCR or other amplification methods. Samples may be prepared or dispensed in multiwell plates. About 100-1000 ng of DNA samples may be prepared in 2-500 ml of final volume.
The nucleic acids are then be fragmented by any of the methods known to those of skill in the art including, for example, using restriction enzymes as described at 9.24-9.28 of Sambrook et al. (1989), shearing by ultrasound and NaOH treatment.
Low pressure shearing is also appropriate, as described by Schriefer et al. (1990) Nucleic Acids Res. 18(24) 7455-6. In this method, DNA samples are passed through a small French pressure cell at a variety of low to intermediate pressures. A lever device allows controlled application of low to intermediate pressures to the cell. The results of these studies indicate that low-pressure shearing is a useful alternative to sonic and enzymatic DNA fragmentation methods.
One particularly suitable way for fragmenting DNA is contemplated to be that using the two base recognition endonuclease, CviJI, described by Fitzgerald et al. (1992) Nucleic Acids Res. 20(14) 3753-62. These authors described an approach for the rapid fragmentation and fractionation of DNA into particular sizes that they contemplated to be suitable for shotgun cloning and sequencing.
The restriction endonuclease CviJI normally cleaves the recognition sequence PuGCPy between the G and C to leave blunt ends. Atypical reaction conditions, which alter the specificity of this enzyme (CviJI**), yield a quasi-random distribution of DNA fragments form the small molecule pUC19 (2688 base pairs). Fitzgerald et al. (1992) quantitatively evaluated the randomness of this fragmentation strategy, using a CviJI** digest of pUC19 that was size fractionated by a rapid gel filtration method and directly ligated, without end repair, to a lac Z minus M13 cloning vector. Sequence analysis of 76 clones showed that CviJI** restricts pyGCPy and PuGCPu, in addition to PuGCPy sites, and that new sequence data is accumulated at a rate consistent with random fragmentation.
As reported in the literature, advantages of this approach compared to sonication and agarose gel fractionation include: smaller amounts of DNA are required (0.2-0.5 ug instead of 2-5 ug); and fewer steps are involved (no preligation, end repair, chemical extraction, or agarose gel electrophoresis and elution are needed).
Irrespective of the manner in which the nucleic acid fragments are obtained or prepared, it is important to denature the DNA to give single stranded pieces available for hybridization. This is achieved by incubating the DNA solution for 2-5 minutes at 80-90° C. The solution is then cooled quickly to 2° C. to prevent renaturation of the DNA fragments before they are contacted with the chip. Phosphate groups must also be removed from genomic DNA by methods known in the art.
5.6 Preparation of DNA Arrays
Arrays may be prepared by spotting DNA samples on a support such as a nylon membrane. Spotting may be performed by using arrays of metal pins (the positions of which correspond to an array of wells in a microtiter plate) to repeated by transfer of about 20 nl of a DNA solution to a nylon membrane. By offset printing, a density of dots higher than the density of the wells is achieved. One to 25 dots may be accommodated in 1 mm2, depending on the type of label used. By avoiding spotting in some preselected number of rows and columns, separate subsets (subarrays) may be formed. Samples in one subarray may be the same genomic segment of DNA (or the same gene) from different individuals, or may be different, overlapped genomic clones. Each of the subarrays may represent replica spotting of the same samples. In one example, a selected gene segment may be amplified from 64 patients. For each patient, the amplified gene segment may be in one 96-well plate (all 96 wells containing the same sample). A plate for each of the 64 patients is prepared. By using a 96-pin device, all samples may be spotted on one 8×12 cm membrane. Subarrays may contain 64 samples, one from each patient. Where the 96 subarrays are identical, the dot span may be 1 mm2 and there may be a 1 mm space between subarrays.
Another approach is to use membranes or plates (available from NUNC, Naperville, Ill.) which may be partitioned by physical spacers e.g. a plastic grid molded over the membrane, the grid being similar to the sort of membrane applied to the bottom of multiwell plates, or hydrophobic strips. A fixed physical spacer is not preferred for imaging by exposure to flat phosphor-storage screens or x-ray films.
5.7 Polypeptides of the Invention
The isolated polypeptides of the invention include, but are not limited to, a polypeptide comprising: the amino acid sequence set forth as any one of SEQ ID NO: 853-1704 or an amino acid sequence encoded by any one of the nucleotide sequences SEQ ID NO: 1-852 or the corresponding full length or mature protein. Polypeptides of the invention also include polypeptides preferably with biological or immunological activity that are encoded by: (a) a polynucleotide having any one of the nucleotide sequences set forth in SEQ ID NO: 1-852 or (b) polynucleotides encoding any one of the amino acid sequences set forth as SEQ ID NO: 853-1704 or (c) polynucleotides that hybridize to the complement of the polynucleotides of either (a) or (b) under stringent hybridization conditions. The invention also provides biologically active or immunologically active variants of any of the amino acid sequences set forth as SEQ ID NO: 853-1704 or the corresponding full length or mature protein; and “substantial equivalents” thereof (e.g., with at least about 65%, at least about 70%, at least about 75%, at least about 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, or 89%, more typically at least about 90%, 91%, 92%, 93%, or 94% and even more typically at least about 95%, 96%, 97%, 98% or 99%, most typically at least about 99% amino acid identity) that retain biological activity. Polypeptides encoded by allelic variants may have a similar, increased, or decreased activity compared to polypeptides comprising SEQ ID NO: 853-1704.
Fragments of the proteins of the present invention which are capable of exhibiting biological activity are also encompassed by the present invention. Fragments of the protein may be in linear form or they may be cyclized using known methods, for example, as described in H. U. Saragovi, et al., Bio/Technology 10, 773-778 (1992) and in R. S. McDowell, et al., J. Amer. Chem. Soc. 114, 9245-9253 (1992), both of which are hereby incorporated herein by reference. Such fragments may be fused to carrier molecules such as immunoglobulins for many purposes, including increasing the valency of protein binding sites.
The present invention also provides both full-length and mature forms (for example, without a signal sequence or precursor sequence) of the disclosed proteins. The protein coding sequence is identified in the sequence listing by translation of the disclosed nucleotide sequences. The mature form of such protein may be obtained by expression of a full-length polynucleotide in a suitable mammalian cell or other host cell. The sequence of the mature form of the protein is also determinable from the amino acid sequence of the full-length form. Where proteins of the present invention are membrane bound, soluble forms of the proteins are also provided. In such forms, part or all of the regions causing the proteins to be membrane bound are deleted so that the proteins are fully secreted from the cell in which it is expressed.
Protein compositions of the present invention may further comprise an acceptable carrier, such as a hydrophilic, e.g., pharmaceutically acceptable, carrier.
The present invention further provides isolated polypeptides encoded by the nucleic acid fragments of the present invention or by degenerate variants of the nucleic acid fragments of the present invention. By “degenerate variant” is intended nucleotide fragments which differ from a nucleic acid fragment of the present invention (e.g., an ORF) by nucleotide sequence but, due to the degeneracy of the genetic code, encode an identical polypeptide sequence. Preferred nucleic acid fragments of the present invention are the ORFs that encode proteins.
A variety of methodologies known in the art can be utilized to obtain any one of the isolated polypeptides or proteins of the present invention. At the simplest level, the amino acid sequence can be synthesized using commercially available peptide synthesizers. The synthetically-constructed protein sequences, by virtue of sharing primary, secondary or tertiary structural and/or conformational characteristics with proteins may possess biological properties in common therewith, including protein activity. This technique is particularly useful in producing small peptides and fragments of larger polypeptides. Fragments are useful, for example, in generating antibodies against the native polypeptide. Thus, they may be employed as biologically active or immunological substitutes for natural, purified proteins in screening of therapeutic compounds and in immunological processes for the development of antibodies.
The polypeptides and proteins of the present invention can alternatively be purified from cells that have been altered to express the desired polypeptide or protein. As used herein, a cell is said to be altered to express a desired polypeptide or protein when the cell, through genetic manipulation, is made to produce a polypeptide or protein which it normally does not produce or which the cell normally produces at a lower level. One skilled in the art can readily adapt procedures for introducing and expressing either recombinant or synthetic sequences into eukaryotic or prokaryotic cells in order to generate a cell that produces one of the polypeptides or proteins of the present invention.
The invention also relates to methods for producing a polypeptide comprising growing a culture of host cells of the invention in a suitable culture medium, and purifying the protein from the cells or the culture in which the cells are grown. For example, the methods of the invention include a process for producing a polypeptide in which a host cell containing a suitable expression vector that includes a polynucleotide of the invention is cultured under conditions that allow expression of the encoded polypeptide. The polypeptide can be recovered from the culture, conveniently from the culture medium, or from a lysate prepared from the host cells and further purified. Preferred embodiments include those in which the protein produced by such process is a full length or mature form of the protein.
In an alternative method, the polypeptide or protein is purified from bacterial cells that naturally produce the polypeptide or protein. One skilled in the art can readily follow known methods for isolating polypeptides and proteins in order to obtain one of the isolated polypeptides or proteins of the present invention. These include, but are not limited to, immunochromatography, High Performance Liquid Chromatography (HPLC), size-exclusion chromatography, ion-exchange chromatography, and immuno-affinity chromatography. See, e.g., Scopes, Protein Purification: Principles and Practice, Springer-Verlag (1994); Sambrook, et al., in Molecular Cloning: A Laboratory Manual; Ausubel et al., Current Protocols in Molecular Biology. Polypeptide fragments that retain biological/immunological activity include fragments comprising greater than about 100 amino acids, or greater than about 200 amino acids, and fragments that encode specific protein domains.
The purified polypeptides can be used in in vitro binding assays that are well known in the art to identify molecules that bind to the polypeptides. These molecules include but are not limited to, for e.g., small molecules, molecules from combinatorial libraries, antibodies or other proteins. The molecules identified in the binding assay are then tested for antagonist or agonist activity in in vivo tissue culture or animal models that are well known in the art. In brief, the molecules are titrated into a plurality of cell cultures or animals and then tested for either cell/animal death or prolonged survival of the animal/cells.
In addition, the peptides of the invention or molecules capable of binding to the peptides may be complexed with toxins, e.g., ricin or cholera, or with other compounds that are toxic to cells. The toxin-binding molecule complex is then targeted to a tumor or other cell by the specificity of the binding molecule for SEQ ID NO: 853-1704.
The protein of the invention may also be expressed as a product of transgenic animals, e.g., as a component of the milk of transgenic cows, goats, pigs, or sheep which are characterized by somatic or germ cells containing a nucleotide sequence encoding the protein.
The proteins provided herein also include proteins characterized by amino acid sequences similar to those of purified proteins but into which modification are naturally provided or deliberately engineered. For example, modifications, in the peptide or DNA sequence, can be made by those skilled in the art using known techniques. Modifications of interest in the protein sequences may include the alteration, substitution, replacement, insertion or deletion of a selected amino acid residue in the coding sequence. For example, one or more of the cysteine residues may be deleted or replaced with another amino acid to alter the conformation of the molecule. Techniques for such alteration, substitution, replacement, insertion or deletion are well known to those skilled in the art (see, e.g., U.S. Pat. No. 4,518,584). Preferably, such alteration, substitution, replacement, insertion or deletion retains the desired activity of the protein. Regions of the protein that are important for the protein function can be determined by various methods known in the art including the alanine-scanning method which involved systematic substitution of single or strings of amino acids with alanine, followed by testing the resulting alanine-containing variant for biological activity. This type of analysis determines the importance of the substituted amino acid(s) in biological activity. Regions of the protein that are important for protein function may be determined by the eMATRIX program or the Pfam program.
Other fragments and derivatives of the sequences of proteins which would be expected to retain protein activity in whole or in part and are useful for screening or other immunological methodologies may also be easily made by those skilled in the art given the disclosures herein. Such modifications are encompassed by the present invention.
The protein may also be produced by operably linking the isolated polynucleotide of the invention to suitable control sequences in one or more insect expression vectors, and employing an insect expression system. Materials and methods for baculovirus/insect cell expression systems are commercially available in kit form from, e.g., Invitrogen, San Diego, Calif., U.S.A. (the MaxBat™ kit), and such methods are well known in the art, as described in Summers and Smith, Texas Agricultural Experiment Station Bulletin No. 1555 (1987), hereby incorporated herein by reference. As used herein, an insect cell capable of expressing a polynucleotide of the present invention is “transformed.”
The protein of the invention may be prepared by culturing transformed host cells under culture conditions suitable to express the recombinant protein. The resulting expressed protein may then be purified from such culture (i.e., from culture medium or cell extracts) using known purification processes, such as gel filtration and ion exchange chromatography. The purification of the protein may also include an affinity column containing agents which will bind to the protein; one or more column steps over such affinity resins as concanavalin A-agarose, heparin-toyopearl™ or Cibacrom blue 3GA Sepharose™; one or more steps involving hydrophobic interaction chromatography using such resins as phenyl ether, butyl ether, or propyl ether; or immunoaffinity chromatography.
Alternatively, the protein of the invention may also be expressed in a form which will facilitate purification. For example, it may be expressed as a fusion protein, such as those of maltose binding protein (MBP), glutathione-S-transferase (GST) or thioredoxin (TRX), or as a His tag. Kits for expression and purification of such fusion proteins are commercially available from New England BioLab (Beverly, Mass.), Pharmacia (Piscataway, N.J.) and Invitrogen, respectively. The protein can also be tagged with an epitope and subsequently purified by using a specific antibody directed to such epitope. One such epitope (“FLAG®”) is commercially available from Kodak (New Haven, Conn.).
Finally, one or more reverse-phase high performance liquid chromatography (RP-HPLC) steps employing hydrophobic RP-HPLC media, e.g., silica gel having pendant methyl or other aliphatic groups, can be employed to further purify the protein. Some or all of the foregoing purification steps, in various combinations, can also be employed to provide a substantially homogeneous isolated recombinant protein. The protein thus purified is substantially free of other mammalian proteins and is defined in accordance with the present invention as an “isolated protein.”
5.8 Determining Polypeptide and Polynucleotide Identity and Similarity
Preferred identity and/or similarity are designed to give the largest match between the sequences tested. Methods to determine identity and similarity are codified in computer programs including, but are not limited to, the GCG program package, including GAP (Devereux, J., et al., Nucleic Acids Research 12(1):387 (1984); Genetics Computer Group, University of Wisconsin, Madison, Wis.), BLASTP, BLASTN, BLASTX, FASTA (Altschul, S. F. et al., J. Molec. Biol. 215:403-410 (1990), PSI-BLAST (Altschul S. F. et al., Nucleic Acids Res. vol. 25, pp. 3389-3402, hereby incorporated herein by reference), the eMatrix software (Wu et al., J. Comp. Biol., vol. 6, pp. 219-235 (1999), hereby incorporated herein by reference), eMotif software (Nevill-Manning et al, ISMB-97, vol 4, pp. 202-209, hereby incorporated herein by reference), the GeneAtlas software Accelrys, Inc. San Diego, Calif.) (Sanchez and Sali (1998) Proc. Natl. Acad. Sci., 95, 13597-13602; Kitson D H et al, (2000) “Remote homology detection using structural modeling—an evaluation” Submitted; Fischer and Eisenberg (1996) Protein Sci. 5, 947-955), and the Kyte-Doolittle hydrophobocity prediction algorithm (J. Mol Biol, 157, pp. 105-31 (1982), hereby incorporated herein by reference). The BLAST programs are publicly available from the National Center for Biotechnology Information (NCBI) and other sources (BLAST Manual, Altschul, S., et al. NCB NLM NIH Bethesda, Md. 20894; Altschul, S., et al., J. Mol. Biol. 215:403-410 (1990).
5.9 Chimeric and Fusion Proteins
The invention also provides chimeric or fusion proteins of the polypeptides of the invention. As used herein “chimeric protein” of the polypeptides of the invention or “fusion protein” of the polypeptides of the invention comprises a polypeptide of the invention operatively linked to a polypeptide not of the invention. A “polypeptide not of the invention” refers to a polypeptide having an amino acid sequence corresponding to a protein that is not substantially homologous to the polypeptides of the invention, e.g., a protein that is different from the polypeptide or polypeptides of the invention in question and that is derived from the same or a different organism. Within a fusion protein of the polypeptides of the invention the polypeptide of the invention can correspond to all or a portion of a polypeptide of the invention. In one embodiment, a fusion protein of the polypeptide of the invention comprises at least one biologically active portion of a polypeptide of the invention. In another embodiment, a fusion protein of the polypeptide of the invention comprises at least two biologically active portions of a polypeptide of the invention. In yet another embodiment, a fusion protein of the polypeptide of the invention comprises at least three biologically active portions of a polypeptide of the invention. Within the fusion protein, the term “operatively-linked” is intended to indicate that the polypeptide of the invention and the polypeptide not of the invention are fused in-frame with one another. The polypeptide not of the invention can be fused to the N-terminus or C-terminus of polypeptide of the invention.
In one embodiment, the fusion protein is a GST-fusion protein of the polypeptides of the invention in which the polypeptide of the invention sequences are fused to the C-terminus of the GST (glutathione S-transferase) sequences. Such fusion proteins can facilitate the purification of recombinant polypeptides of the invention. In another embodiment, the fusion protein is a polypeptide of the invention containing a heterologous signal sequence at its N-terminus. In certain host cells (e.g., mammalian host cells), expression and/or secretion of the polypeptides of the invention can be increased through use of a heterologous signal sequence.
In yet another embodiment, the fusion protein is an immunoglobulin fusion protein of the polypeptide of the invention in which the sequences corresponding to the polypeptides of the invention are fused to sequences derived from a member of the immunoglobulin protein family. The immunoglobulin fusion proteins of the polypeptides of the invention can be incorporated into pharmaceutical compositions and administered to a subject to inhibit an interaction between ligand that is a polypeptide of the invention and a polypeptide of the invention on the surface of a cell, to thereby suppress signal transduction in vivo mediated by polypeptides of the invention. The immunoglobulin fusion proteins of the polypeptides of the invention can be used to affect the bioavailability of a polypeptide of the invention cognate ligand. Inhibition of the polypeptide of the invention ligand/polypeptide of the invention interaction can be useful therapeutically for both the treatment of proliferative and differentiative disorders, as well as modulating (e.g. promoting or inhibiting) cell survival. Moreover, the immunoglobulin fusion proteins of the polypeptides of the invention can be used as immunogens to produce anti-polypeptides of the invention-like antibodies in a subject, to purify ligands to the polypeptides of the invention, and in screening assays to identify molecules that inhibit the interaction of polypeptides of the invention with ligands for the polypeptide of the invention.
Chimeric or fusion protein of the polypeptides of the invention can be produced by standard recombinant DNA techniques. For example, DNA fragments coding for the different polypeptide sequences are ligated together in-frame in accordance with conventional techniques, e.g., by employing blunt-ended or stagger-ended termini for ligation, restriction enzyme digestion to provide for appropriate termini, filling-in of cohesive ends as appropriate, alkaline phosphatase treatment to avoid undesirable joining, and enzymatic ligation. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments can be carried out using anchor primers that give rise to complementary overhangs between two consecutive gene fragments that can subsequently be annealed and reamplified to generate a chimeric gene sequence (see, e.g., Ausubel, et al. (eds.) CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, John Wiley & Sons, 1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST polypeptide). A nucleic acid encoding a polynucleotide or polypeptide of the invention can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the polypeptide of the invention.
5.10 Hosts
The present invention further provides host cells genetically engineered to contain the polynucleotides of the invention. For example, such host cells may contain nucleic acids of the invention introduced into the host cell using known transformation, transfection or infection methods. The present invention still further provides host cells genetically engineered to express the polynucleotides of the invention, wherein such polynucleotides are in operative association with a regulatory sequence heterologous to the host cell which drives expression of the polynucleotides in the cell.
The host cell can be a higher eukaryotic host cell, such as a mammalian cell, a lower eukaryotic host cell, such as a yeast cell, or the host cell can be a prokaryotic cell, such as a bacterial cell. Introduction of the recombinant construct into the host cell can be effected by methods well-known to those of skill in the art, for example calcium phosphate transfection, DEAE, dextran mediated transfection, or electroporation (Davis, L. et al., Basic Methods in Molecular Biology (1986)). The host cells containing one of the polynucleotides of the invention, can be used in conventional manners to produce the gene product encoded by the isolated fragment (in the case of an ORF) or can be used to produce a heterologous protein under the control of the EMF.
Any host/vector system can be used to express one or more of the ORFs of the present invention. These include, but are not limited to, eukaryotic hosts such as HeLa cells, Cv-1 cell, COS cells, and Sf9 cells, as well as prokaryotic host such as E. coli and B. subtilis. The most preferred cells are those which do not normally express the particular polypeptide or protein or which expresses the polypeptide or protein at low natural level. Mature proteins can be expressed in mammalian cells, yeast, bacteria, or other cells under the control of appropriate promoters. Cell-free translation systems can also be employed to produce such proteins using RNAs derived from the DNA constructs of the present invention. Appropriate cloning and expression vectors for use with prokaryotic and eukaryotic hosts are described by Sambrook, et al., in Molecular Cloning: A Laboratory Manual, Second Edition, Cold Spring Harbor, N.Y. (1989), the disclosure of which is hereby incorporated herein by reference.
Various mammalian cell culture systems can also be employed to express recombinant protein. Examples of mammalian expression systems include the COS-7 lines of monkey kidney fibroblasts, described by Gluzman, Cell 23:175 (1981), and other cell lines capable of expressing a compatible vector, for example, the C127, 3T3, CHO, HeLa and BHK cell tines. Mammalian expression vectors will comprise an origin of replication, a suitable promoter, and also any necessary ribosome binding sites, polyadenylation site, splice donor and acceptor sites, transcriptional termination sequences, and 5′ flanking nontranscribed sequences. DNA sequences derived from the SV40 viral genome, for example, SV40 origin, early promoter, enhancer, splice, and polyadenylation sites may be used to provide the required nontranscribed genetic elements. Recombinant polypeptides and proteins produced in bacterial culture are usually isolated by initial extraction from cell pellets, followed by one or more salting-out, aqueous ion exchange or size exclusion chromatography steps. Protein refolding steps can be used, as necessary, in completing configuration of the mature protein. Finally, high performance liquid chromatography (HPLC) can be employed for final purification steps. Microbial cells employed in expression of proteins can be disrupted by any convenient method, including freeze-thaw cycling, sonication, mechanical disruption, or use of cell lysing agents.
A number of types of cells may act as suitable host cells for expression of the protein. Mammalian host cells include, for example, monkey COS cells, Chinese Hamster Ovary (CHO) cells, human kidney 293 cells, human epidermal A431 cells, human Colo205 cells, 3T3 cells, CV-1 cells, other transformed primate cell lines, normal diploid cells, cell strains derived from in vitro culture of primary tissue, primary explants, HeLa cells, mouse L cells, BHK, HL-60, U937, HaK or Jurkat cells.
Alternatively, it may be possible to produce the protein in lower eukaryotes such as yeast or in prokaryotes such as bacteria. Potentially suitable yeast strains include Saccharomyces cerevisiae, Schizosaccharomyces pombe, Kluyveromyces strains, Candida, or any yeast strain capable of expressing heterologous proteins. Potentially suitable bacterial strains include Escherichia coli, Bacillus subtilis, Salmonella typhimurium, or any bacterial strain capable of expressing heterologous proteins. If the protein is made in yeast or bacteria, it may be necessary to modify the protein produced therein, for example by phosphorylation or glycosylation of the appropriate sites, in order to obtain the functional protein. Such covalent attachments may be accomplished using known chemical or enzymatic methods.
In another embodiment of the present invention, cells and tissues may be engineered to express an endogenous gene comprising the polynucleotides of the invention under the control of inducible regulatory elements, in which case the regulatory sequences of the endogenous gene may be replaced by homologous recombination. As described herein, gene targeting can be used to replace a gene's existing regulatory region with a regulatory sequence isolated from a different gene or a novel regulatory sequence synthesized by genetic engineering methods. Such regulatory sequences may be comprised of promoters, enhancers, scaffold-attachment regions, negative regulatory elements, transcriptional initiation sites, regulatory protein binding sites or combinations of said sequences. Alternatively, sequences which affect the structure or stability of the RNA or protein produced may be replaced, removed, added, or otherwise modified by targeting, including polyadenylation signals, mRNA stability elements, splice sites, leader sequences for enhancing or modifying transport or secretion properties of the protein, or other sequences which alter or improve the function or stability of protein or RNA molecules.
The targeting event may be a simple insertion of the regulatory sequence, placing the gene under the control of the new regulatory sequence, e.g., inserting a new promoter or enhancer or both upstream of a gene. Alternatively, the targeting event may be a simple deletion of a regulatory element, such as the deletion of a tissue-specific negative regulatory element. Alternatively, the targeting event may replace an existing element; for example, a tissue-specific enhancer can be replaced by an enhancer that has broader or different cell-type specificity than the naturally occurring elements. Here, the naturally occurring sequences are deleted and new sequences are added. In all cases, the identification of the targeting event may be facilitated by the use of one or more selectable marker genes that are contiguous with the targeting DNA, allowing for the selection of cells in which the exogenous DNA has integrated into the host cell genome. The identification of the targeting event may also be facilitated by the use of one or more marker genes exhibiting the property of negative selection, such that the negatively selectable marker is linked to the exogenous DNA, but configured such that the negatively selectable marker flanks the targeting sequence, and such that a correct homologous recombination event with sequences in the host cell genome does not result in the stable integration of the negatively selectable marker. Markers useful for this purpose include the Herpes Simplex Virus thymidine kinase (TK) gene or the bacterial xanthine-guanine phosphoribosyl-transferase (gpt) gene.
The gene targeting or gene activation techniques which can be used in accordance with this aspect of the invention are more particularly described in U.S. Pat. No. 5,272,071 to Chappel; U.S. Pat. No. 5,578,461 to Sherwin et al.; International Application No. PCT/US92/09627 (WO93/09222) by Selden et al.; and International Application No. PCT/US90/06436 (WO91/06667) by Skoultchi et al., each of which is incorporated by reference herein in its entirety.
5.11 Gene Therapy
Mutations in the polynucleotides of the invention gene may result in loss of normal function of the encoded protein. The invention thus provides gene therapy to restore normal activity of the polypeptides of the invention; or to treat disease states involving polypeptides of the invention. Delivery of a functional gene encoding polypeptides of the invention to appropriate cells is effected ex vivo, in situ, or in vivo by use of vectors, and more particularly viral vectors (e.g., adenovirus, adeno-associated virus, or a retrovirus), or ex vivo by use of physical DNA transfer methods (e.g., liposomes or chemical treatments). See, for example, Anderson, Nature, supplement to vol. 392, no. 6679, pp. 25-20 (1998). For additional reviews of gene therapy technology see Friedmann, Science, 244: 1275-1281 (1989); Verma, Scientific American: 68-84 (1990); and Miller, Nature, 357: 455-460 (1992). Introduction of any one of the nucleotides of the present invention or a gene encoding the polypeptides of the present invention can also be accomplished with extrachromosomal substrates (transient expression) or artificial chromosomes (stable expression). Cells may also be cultured ex vivo in the presence of proteins of the present invention in order to proliferate or to produce a desired effect on or activity in such cells. Treated cells can then be introduced in vivo for therapeutic purposes. Alternatively, it is contemplated that in other human disease states, preventing the expression of or inhibiting the activity of polypeptides of the invention will be useful in treating the disease states. It is contemplated that antisense therapy or gene therapy could be applied to negatively regulate the expression of polypeptides of the invention.
Other methods inhibiting expression of a protein include the introduction of antisense molecules to the nucleic acids of the present invention, their complements, or their translated RNA sequences, by methods known in the art. Further, the polypeptides of the present invention can be inhibited by using targeted deletion methods, or the insertion of a negative regulatory element such as a silencer, which is tissue specific.
The present invention still further provides cells genetically engineered in vivo to express the polynucleotides of the invention, wherein such polynucleotides are in operative association with a regulatory sequence heterologous to the host cell which drives expression of the polynucleotides in the cell. These methods can be used to increase or decrease the expression of the polynucleotides of the present invention.
Knowledge of DNA sequences provided by the invention allows for modification of cells to permit, increase, or decrease, expression of endogenous polypeptide. Cells can be modified (e.g., by homologous recombination) to provide increased polypeptide expression by replacing, in whole or in part, the naturally occurring promoter with all or part of a heterologous promoter so that the cells express the protein at higher levels. The heterologous promoter is inserted in such a manner that it is operatively linked to the desired protein encoding sequences. See, for example, PCT International Publication No. WO 94/12650, PCT International Publication No. WO 92/20808, and PCT International Publication No. WO 91/09955. It is also contemplated that, in addition to heterologous promoter DNA, amplifiable marker DNA (e.g., ada, dhfr, and the multifunctional CAD gene which encodes carbamyl phosphate synthase, aspartate transcarbamylase, and dihydroorotase) and/or intron DNA may be inserted along with the heterologous promoter DNA. If linked to the desired protein coding sequence, amplification of the marker DNA by standard selection methods results in co-amplification of the desired protein coding sequences in the cells.
In another embodiment of the present invention, cells and tissues may be engineered to express an endogenous gene comprising the polynucleotides of the invention under the control of inducible regulatory elements, in which case the regulatory sequences of the endogenous gene may be replaced by homologous recombination. As described herein, gene targeting can be used to replace a gene's existing regulatory region with a regulatory sequence isolated from a different gene or a novel regulatory sequence synthesized by genetic engineering methods. Such regulatory sequences may be comprised of promoters, enhancers, scaffold-attachment regions, negative regulatory elements, transcriptional initiation sites, regulatory protein binding sites or combinations of said sequences. Alternatively, sequences which affect the structure or stability of the RNA or protein produced may be replaced, removed, added, or otherwise modified by targeting. These sequences include polyadenylation signals, mRNA stability elements, splice sites, leader sequences for enhancing or modifying transport or secretion properties of the protein, or other sequences which alter or improve the function or stability of protein or RNA molecules.
The targeting event may be a simple insertion of the regulatory sequence, placing the gene under the control of the new regulatory sequence, e.g., inserting a new promoter or enhancer or both upstream of a gene. Alternatively, the targeting event may be a simple deletion of a regulatory element, such as the deletion of a tissue-specific negative regulatory element. Alternatively, the targeting event may replace an existing element; for example, a tissue-specific enhancer can be replaced by an enhancer that has broader or different cell-type specificity than the naturally occurring elements. Here, the naturally occurring sequences are deleted and new sequences are added. In all cases, the identification of the targeting event may be facilitated by the use of one or more selectable marker genes that are contiguous with the targeting DNA, allowing for the selection of cells in which the exogenous DNA has integrated into the cell genome. The identification of the targeting event may also be facilitated by the use of one or more marker genes exhibiting the property of negative selection, such that the negatively selectable marker is linked to the exogenous DNA, but configured such that the negatively selectable marker flanks the targeting sequence, and such that a correct homologous recombination event with sequences in the host cell genome does not result in the stable integration of the negatively selectable marker. Markers useful for this purpose include the Herpes Simplex Virus thymidine kinase (TK) gene or the bacterial xanthine-guanine phosphoribosyl-transferase (gpt) gene.
The gene targeting or gene activation techniques which can be used in accordance with this aspect of the invention are more particularly described in U.S. Pat. No. 5,272,071 to Chappel; U.S. Pat. No. 5,578,461 to Sherwin et al.; International Application No. PCT/US92/09627 (WO93/09222) by Selden et al.; and International Application No. PCT/US90/06436 (WO91/06667) by Skoultchi et al., each of which is incorporated by reference herein in its entirety.
5.12 Antibodies
Also included in the invention are antibodies to proteins, or fragments of proteins of the invention. The term “antibody” as used herein refers to immunoglobulin molecules and immunologically active portions of immunoglobulin (Ig) molecules, i.e., molecules that contain an antigen-binding site that specifically binds (immunoreacts with) an antigen. Such antibodies include, but are not limited to, polyclonal, monoclonal, chimeric, single chain, Fab, Fab′ and F(ab′)2 fragments, and an Fab expression library. In general, an antibody molecule obtained from humans relates to any of the classes IgG, IgM, IgA, IgE and IgD, which differ from one another by the nature of the heavy chain present in the molecule. Certain classes have subclasses as well, such as IgG, IgG2, and others. Furthermore, in humans, the light chain may be a kappa chain or a lambda chain. Reference herein to antibodies includes a reference to all such classes, subclasses and types of human antibody species.
An isolated related protein of the invention may be intended to serve as an antigen, or a portion or fragment thereof, and additionally can be used as an immunogen to generate antibodies that immunospecifically bind the antigen, using standard techniques for polyclonal and monoclonal antibody preparation. The full-length protein can be used or, alternatively, the invention provides antigenic peptide fragments of the antigen for use as immunogens. An antigenic peptide fragment comprises at least 6 amino acid residues of the amino acid sequence of the full length protein, such as an amino acid sequence shown in SEQ ID NO: 853-1704, or designated in Tables from Examples 2, 4, and 5 and encompasses an epitope thereof such that an antibody raised against the peptide forms a specific immune complex with the full length protein or with any fragment that contains the epitope. Preferably, the antigenic peptide comprises at least 10 amino acid residues, or at least 15 amino acid residues, or at least 20 amino acid residues, or at least 30 amino acid residues. Preferred epitopes encompassed by the antigenic peptide are regions of the protein that are located on its surface; commonly these are hydrophilic regions.
In certain embodiments of the invention, at least one epitope encompassed by the antigenic peptide is a surface region of the protein, e.g., a hydrophilic region. A hydrophobicity analysis of the human related protein sequence will indicate which regions of a related protein are particularly hydrophilic and, therefore, are likely to encode surface residues useful for targeting antibody production. As a means for targeting antibody production, hydropathy plots showing regions of hydrophilicity and hydrophobicity may be generated by any method well known in the art, including, for example, the Kyte Doolittle or the Hopp Woods methods, either with or without Fourier transformation. See, e.g., Hopp and Woods, Proc. Nat. Acad. Sci. USA 78: 3824-3828 (1981); Kyte and Doolittle, J. Mol. Biol. 157: 105-142 (1982), each of which is incorporated herein by reference in its entirety. Antibodies that are specific for one or more domains within an antigenic protein, or derivatives, fragments, analogs or homologs thereof, are also provided herein.
A protein of the invention, or a derivative, fragment, analog, homolog or ortholog thereof, may be utilized as an immunogen in the generation of antibodies that immunospecifically bind these protein components.
The terms “specific for” and “selective for” indicate that the variable regions of the antibodies of the invention recognize and bind polypeptides of the invention exclusively (i.e., able to distinguish the polypeptide of the invention from other similar polypeptides despite sequence identity, homology, or similarity found in the family of polypeptides), but may also interact with other proteins (for example, S. aureus protein A or other antibodies in ELISA techniques) through interactions with sequences outside the variable region of the antibodies, and in particular, in the constant region of the molecule. Screening assays to determine binding specificity of an antibody of the invention are well known and routinely practiced in the art. For a comprehensive discussion of such assays, see Harlow et al. (Eds), Antibodies A Laboratory Manual; Cold Spring Harbor Laboratory; Cold Spring Harbor, N.Y. (1988), Chapter 6. Antibodies that recognize and bind fragments of the polypeptides of the invention are also contemplated, provided that the antibodies are first and foremost specific for, as defined above, full-length polypeptides of the invention. As with antibodies that are specific for full length polypeptides of the invention, antibodies of the invention that recognize fragments are those which can distinguish polypeptides from the same family of polypeptides despite inherent sequence identity, homology, or similarity found in the family of proteins.
Antibodies of the invention are useful for, for example, therapeutic purposes (by modulating activity of a polypeptide of the invention, or immunotargeting cells expressing said polypeptide of the invention to induce cell death or targeting by the immune system), diagnostic purposes to detect or quantitate a polypeptide of the invention, as well as purification of a polypeptide of the invention. Kits comprising an antibody of the invention for any of the purposes described herein are also comprehended. In general, a kit of the invention also includes a control antigen for which the antibody is immunospecific. The invention further provides a hybridoma that produces an antibody according to the invention. Antibodies of the invention are useful for detection and/or purification of the polypeptides of the invention.
Monoclonal antibodies binding to the protein of the invention may be useful diagnostic agents for the immunodetection of the protein. Neutralizing monoclonal antibodies binding to the protein may also be useful therapeutics for both conditions associated with the protein and also in the treatment of some forms of cancer where abnormal expression of the protein is involved. In the case of cancerous cells or leukemic cells, neutralizing monoclonal antibodies against the protein may be useful in detecting and preventing the metastatic spread of the cancerous cells, which may be mediated by the protein.
The labeled antibodies of the present invention can be used for in vitro, in vivo, and in situ assays to identify cells or tissues in which a fragment of the polypeptide of interest is expressed. The antibodies may also be used directly in therapies or other diagnostics. The present invention further provides the above-described antibodies immobilized on a solid support. Examples of such solid supports include plastics such as polycarbonate, complex carbohydrates such as agarose and Sepharose®, acrylic resins and such as polyacrylamide and latex beads. Techniques for coupling antibodies to such solid supports are well known in the art (Weir, D. M. et al., “Handbook of Experimental Immunology” 4th Ed., Blackwell Scientific Publications, Oxford, England, Chapter 10 (1986); Jacoby, W. D. et al., Meth. Enzym. 34 Academic Press, N.Y. (1974)). The immobilized antibodies of the present invention can be used for in vitro, in vivo, and in situ assays as well as for immuno-affinity purification of the proteins of the present invention.
Various procedures known within the art may be used for the production of polyclonal or monoclonal antibodies directed against a protein of the invention, or against derivatives, fragments, analogs homologs or orthologs thereof (see, for example, Antibodies: A Laboratory Manual, Harlow E, and Lane D, 1988, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., incorporated herein by reference). Some of these antibodies are discussed below.
5.12.1 Polyclonal Antibodies
For the production of polyclonal antibodies, various suitable host animals (e.g., rabbit, goat, mouse or other mammal) may be immunized by one or more injections with the native protein, a synthetic variant thereof, or a derivative of the foregoing. An appropriate immunogenic preparation can contain, for example, the naturally occurring immunogenic protein, a chemically synthesized polypeptide representing the immunogenic protein, or a recombinantly expressed immunogenic protein. Furthermore, the protein may be conjugated to a second protein known to be immunogenic in the mammal being immunized. Examples of such immunogenic proteins include but are not limited to keyhole limpet hemocyanin, serum albumin, bovine thyroglobulin, and soybean trypsin inhibitor. The preparation can further include an adjuvant. Various adjuvants used to increase the immunological response include, but are not limited to, Freund's (complete and incomplete), mineral gels (e.g., aluminum hydroxide), surface-active substances (e.g., lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, dinitrophenol, etc.), adjuvants usable in humans such as Bacille Calmette-Guerin and Corynebacterium parvum, or similar immunostimulatory agents. Additional examples of adjuvants that can be employed include MPL-TDM adjuvant (monophosphoryl Lipid A, synthetic trehalose dicorynomycolate).
The polyclonal antibody molecules directed against the immunogenic protein can be isolated from the mammal (e.g., from the blood) and further purified by well known techniques, such as affinity chromatography using protein A or protein G, which provide primarily the IgG fraction of immune serum. Subsequently, or alternatively, the specific antigen which is the target of the immunoglobulin sought, or an epitope thereof, may be immobilized on a column to purify the immune specific antibody by immunoaffinity chromatography. Purification of immunoglobulins is discussed, for example, by D. Wilkinson (The Scientist, published by The Scientist, Inc., Philadelphia Pa., Vol. 14, No. 8 (Apr. 17, 2000), pp. 25-28).
5.12.2 Monoclonal Antibodies
The term “monoclonal antibody” (MAb) or “monoclonal antibody composition”, as used herein, refers to a population of antibody molecules that contain only one molecular species of antibody molecule consisting of a unique light chain gene product and a unique heavy chain gene product. In particular, the complementarity determining regions (CDRs) of the monoclonal antibody are identical in all the molecules of the population. MAbs thus contain an antigen-binding site capable of immunoreacting with a particular epitope of the antigen characterized by a unique binding affinity for it.
Monoclonal antibodies can be prepared using hybridoma methods, such as those described by Kohler and Milstein, Nature, 256:495 (1975). In a hybridoma method, a mouse, hamster, or other appropriate host animal, is typically immunized with an immunizing agent to elicit lymphocytes that produce or are capable of producing antibodies that will specifically bind to the immunizing agent. Alternatively, the lymphocytes can be immunized in vitro.
The immunizing agent will typically include the protein antigen, a fragment thereof or a fusion protein thereof. Generally, either peripheral blood lymphocytes are used if cells of human origin are desired, or spleen cells or lymph node cells are used if non-human mammalian sources are desired. The lymphocytes are then fused with an immortalized cell line using a suitable fusing agent, such as polyethylene glycol, to form a hybridoma cell (Goding, Monoclonal Antibodies: Principles and Practice, Academic Press, (1986) pp. 59-103). Immortalized cell lines are usually transformed mammalian cells, particularly myeloma cells of rodent, bovine and human origin. Usually, rat or mouse myeloma cell lines are employed. The hybridoma cells can be cultured in a suitable culture medium that preferably contains one or more substances that inhibit the growth or survival of the unfused, immortalized cells. For example, if the parental cells lack the enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT or HPRT), the culture medium for the hybridomas typically will include hypoxanthine, aminopterin, and thymidine (“HAT medium”), which substances prevent the growth of HGPRT-deficient cells.
Preferred immortalized cell lines are those that fuse efficiently, support stable high level expression of antibody by the selected antibody-producing cells, and are sensitive to a medium such as HAT medium. More preferred immortalized cell lines are murine myeloma lines, which can be obtained, for instance, from the Salk Institute Cell Distribution Center, San Diego, Calif. and the American Type Culture Collection, Manassas, Va. Human myeloma and mouse-human heteromyeloma cell lines also have been described for the production of human monoclonal antibodies (Kozbor, J. Immunol., 133:3001 (1984); Brodeur et al., Monoclonal Antibody Production Techniques and Applications, Marcel Dekker, Inc., New York, (1987) pp. 51-63).
The culture medium in which the hybridoma cells are cultured can then be assayed for the presence of monoclonal antibodies directed against the antigen. Preferably, the binding specificity of monoclonal antibodies produced by the hybridoma cells is determined by immunoprecipitation or by an in vitro binding assay, such as radioimmunoassay (RIA) or enzyme-linked immunoabsorbent assay (ELISA). Such techniques and assays are known in the art. The binding affinity of the monoclonal antibody can, for example, be determined by the Scatchard analysis of Munson and Pollard, Anal. Biochem., 107:220 (1980). Preferably, antibodies having a high degree of specificity and a high binding affinity for the target antigen are isolated.
After the desired hybridoma cells are identified, the clones can be subcloned by limiting dilution procedures and grown by standard methods. Suitable culture media for this purpose include, for example, Dulbecco's Modified Eagle's Medium and RPMI-1640 medium. Alternatively, the hybridoma cells can be grown in vivo as ascites in a mammal.
The monoclonal antibodies secreted by the subclones can be isolated or purified from the culture medium or ascites fluid by conventional immunoglobulin purification procedures such as, for example, protein A-Sepharose, hydroxylapatite chromatography, gel electrophoresis, dialysis, or affinity chromatography.
The monoclonal antibodies can also be made by recombinant DNA methods, such as those described in U.S. Pat. No. 4,816,567. DNA encoding the monoclonal antibodies of the invention can be readily isolated and sequenced using conventional procedures (e.g., by using oligonucleotide probes that are capable of binding specifically to genes encoding the heavy and light chains of murine antibodies). The hybridoma cells of the invention serve as a preferred source of such DNA. Once isolated, the DNA can be placed into expression vectors, which are then transfected into host cells such as simian COS cells, Chinese hamster ovary (CHO) cells, or myeloma cells that do not otherwise produce immunoglobulin protein, to obtain the synthesis of monoclonal antibodies in the recombinant host cells. The DNA also can be modified, for example, by substituting the coding sequence for human heavy and light chain constant domains in place of the homologous murine sequences (U.S. Pat. No. 4,816,567; Morrison, Nature 368:812-13 (1994)) or by covalently joining to the immunoglobulin coding sequence all or part of the coding sequence for a non-immunoglobulin polypeptide. Such a non-immunoglobulin polypeptide can be substituted for the constant domains of an antibody of the invention, or can be substituted for the variable domains of one antigen-combining site of an antibody of the invention to create a chimeric bivalent antibody.
5.12.3 Humanized Antibodies
The antibodies directed against the protein antigens of the invention can further comprise humanized antibodies or human antibodies. These antibodies are suitable for administration to humans without engendering an immune response by the human against the administered immunoglobulin. Humanized forms of antibodies are chimeric immunoglobulins, immunoglobulin chains or fragments thereof (such as Fv, Fab, Fab′, F(ab′)2 or other antigen-binding subsequences of antibodies) that are principally comprised of the sequence of a human immunoglobulin, and contain minimal sequence derived from a non-human immunoglobulin. Humanization can be performed following the method of Winter and co-workers (Jones et al., Nature, 321:522-525 (1986); Riechmann, et al., Nature, 332:323-327 (1988); Verhoeyen, et al., Science, 239:1534-1536 (1988)), by substituting rodent CDRs or CDR sequences for the corresponding sequences of a human antibody. (See also U.S. Pat. No. 5,225,539). In some instances, Fv framework residues of the human immunoglobulin are replaced by corresponding non-human residues. Humanized antibodies can also comprise residues that are found neither in the recipient antibody nor in the imported CDR or framework sequences. In general, the humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all of the CDR regions correspond to those of a non-human immunoglobulin and all or substantially all of the framework regions are those of a human immunoglobulin consensus sequence. The humanized antibody optimally also will comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin (Jones et al., 1986; Riechhmann et al., 1988; and Presta, Curr. Op. Struct. Biol., 2:593-596 (1992)).
5.12.4 Human Antibodies
Fully human antibodies relate to antibody molecules in which essentially the entire sequences of both the light chain and the heavy chain, including the CDRs, arise from human genes. Such antibodies are termed “human antibodies” or “fully human antibodies” herein. Human monoclonal antibodies can be prepared by the trioma technique; the human B-cell hybridoma technique (see Kozbor, et al., Immunol Today 4: 72 (1983)) and the EBV hybridoma technique to produce human monoclonal antibodies (see Cole, et al., 1985 In: MONOCLONAL ANTIBODIES AND CANCER THERAPY, Alan R. Liss, Inc., pp. 77-96). Human monoclonal antibodies may be utilized in the practice of the present invention and may be produced by using human hybridomas (see Cote, et al., Proc Natl Acad Sci USA 80: 2026-2030 (1983)) or by transforming human B-cells with Epstein Barr Virus in vitro (see Cole, et al., 1985 In: MONOCLONAL ANTIBODIES AND CANCER THERAPY, Alan R. Liss, Inc., pp. 77-96).
In addition, human antibodies can also be produced using additional techniques, including phage display libraries (Hoogenboom and Winter, J. Mol. Biol., 227:381 (1991); Marks et al., J. Mol. Biol., 222:581 (1991)). Similarly, human antibodies can be made by introducing human immunoglobulin loci into transgenic animals, e.g., mice in which the endogenous immunoglobulin genes have been partially or completely inactivated. Upon challenge, human antibody production is observed, which closely resembles that seen in humans in all respects, including gene rearrangement, assembly, and antibody repertoire. This approach is described, for example, in U.S. Pat. Nos. 5,545,807; 5,545,806; 5,569,825; 5,625,126; 5,633,425; 5,661,016, and in Marks et al. (Bio/Technology 10,:779-783 (1992)); Lonberg et al. (Nature 368:856-859 (1994)); Morrison (Nature 368:812-13 (1994)); Fishwild et al, (Nature Biotechnology, 14:845-51 (1996)); Neuberger (Nature Biotechnology, 14:826 (1996)); and Lonberg and Huszar (Intern. Rev. Immunol. 13:65-93 (1995)).
Human antibodies may additionally be produced using transgenic nonhuman animals which are modified so as to produce fully human antibodies rather than the animal's endogenous antibodies in response to challenge by an antigen. (See PCT publication WO94/02602). The endogenous genes encoding the heavy and light immunoglobulin chains in the nonhuman host have been incapacitated, and active loci encoding human heavy and light chain immunoglobulins are inserted into the host's genome. The human genes are incorporated, for example, using yeast artificial chromosomes containing the requisite human DNA segments. An animal which provides all the desired modifications is then obtained as progeny by crossbreeding intermediate transgenic animals containing fewer than the full complement of the modifications. The preferred embodiment of such a nonhuman animal is a mouse, and is termed the Xenomouse™ as disclosed in PCT publications WO 96/33735 and WO 96/34096. This animal produces B cells which secrete fully human immunoglobulins. The antibodies can be obtained directly from the animal after immunization with an immunogen of interest, as, for example, a preparation of a polyclonal antibody, or alternatively from immortalized B cells derived from the animal, such as hybridomas producing monoclonal antibodies. Additionally, the genes encoding the immunoglobulins with human variable regions can be recovered and expressed to obtain the antibodies directly, or can be further modified to obtain analogs of antibodies such as, for example, single chain Fv molecules.
An example of a method of producing a nonhuman host, exemplified as a mouse, lacking expression of an endogenous immunoglobulin heavy chain is disclosed in U.S. Pat. No. 5,939,598. It can be obtained by a method including deleting the J segment genes from at least one endogenous heavy chain locus in an embryonic stem cell to prevent rearrangement of the locus and to prevent formation of a transcript of a rearranged immunoglobulin heavy chain locus, the deletion being effected by a targeting vector containing a gene encoding a selectable marker; and producing from the embryonic stem cell a transgenic mouse whose somatic and germ cells contain the gene encoding the selectable marker.
A method for producing an antibody of interest, such as a human antibody, is disclosed in U.S. Pat. No. 5,916,771. It includes introducing an expression vector that contains a nucleotide sequence encoding a heavy chain into one mammalian host cell in culture, introducing an expression vector containing a nucleotide sequence encoding a light chain into another mammalian host cell, and fusing the two cells to form a hybrid cell. The hybrid cell expresses an antibody containing the heavy chain and the light chain.
In a further improvement on this procedure, a method for identifying a clinically relevant epitope on an immunogen, and a correlative method for selecting an antibody that binds immunospecifically to the relevant epitope with high affinity, are disclosed in PCT publication WO 99/53049.
5.12.5 Fab Fragments and Single Chain Antibodies
According to the invention, techniques can be adapted for the production of single-chain antibodies specific to an antigenic protein of the invention (see e.g., U.S. Pat. No. 4,946,778). In addition, methods can be adapted for the construction of Fab expression libraries (see e.g., Huse, et al., Science 246:1275-1281 (1989)) to allow rapid and effective identification of monoclonal Fab fragments with the desired specificity for a protein or derivatives, fragments, analogs or homologs thereof. Antibody fragments that contain the idiotypes to a protein antigen may be produced by techniques known in the art including, but not limited to: (i) an F(ab′)2 fragment produced by pepsin digestion of an antibody molecule; (ii) an Fab fragment generated by reducing the disulfide bridges of an F(ab′) 2 fragment; (iii) an Fab fragment generated by the treatment of the antibody molecule with papain and a reducing agent and (iv) Fv fragments.
5.12.6 Bispecific Antibodies
Bispecific antibodies are monoclonal, preferably human or humanized, antibodies that have binding specificities for at least two different antigens. In the present case, one of the binding specificities is for an antigenic protein of the invention. The second binding target is any other antigen, and advantageously is a cell-surface protein or receptor or receptor subunit.
Methods for making bispecific antibodies are known in the art. Traditionally, the recombinant production of bispecific antibodies is based on the co-expression of two immunoglobulin heavy-chain/light-chain pairs, where the two heavy chains have different specificities (Milstein and Cuello, Nature, 305:537-539 (1983)). Because of the random assortment of immunoglobulin heavy and light chains, these hybridomas (quadromas) produce a potential mixture of ten different antibody molecules, of which only one has the correct bispecific structure. The purification of the correct molecule is usually accomplished by affinity chromatography steps. Similar procedures are disclosed in WO 93/08829, published 13 May 1993, and in Traunecker et al., EMBO J., 10:3655-3659 (1991).
Antibody variable domains with the desired binding specificities (antibody-antigen combining sites) can be fused to immunoglobulin constant domain sequences. The fusion preferably is with an immunoglobulin heavy-chain constant domain, comprising at least part of the hinge, CH2, and CH3 regions. It is preferred to have the first heavy-chain constant region (CH1) containing the site necessary for light-chain binding present in at least one of the fusions. DNAs encoding the immunoglobulin heavy-chain fusions and, if desired, the immunoglobulin light chain, are inserted into separate expression vectors, and are co-transfected into a suitable host organism. For further details of generating bispecific antibodies see, for example, Suresh et al., Methods in Enzymology, 121:210 (1986).
According to another approach described in WO 96/27011, the interface between a pair of antibody molecules can be engineered to maximize the percentage of heterodimers which are recovered from recombinant cell culture. The preferred interface comprises at least a part of the CH3 region of an antibody constant domain. In this method, one or more small amino acid side chains from the interface of the first antibody molecule are replaced with larger side chains (e.g. tyrosine or tryptophan). Compensatory “cavities” of identical or similar size to the large side chain(s) are created on the interface of the second antibody molecule by replacing large amino acid side chains with smaller ones (e.g. alanine or threonine). This provides a mechanism for increasing the yield of the heterodimer over other unwanted end-products such as homodimers.
Bispecific antibodies can be prepared as full-length antibodies or antibody fragments (e.g. F(ab′)2 bispecific antibodies). Techniques for generating bispecific antibodies from antibody fragments have been described in the literature. For example, bispecific antibodies can be prepared using chemical linkage. Brennan et al., Science 229:81 (1985) describe a procedure wherein intact antibodies are proteolytically cleaved to generate F(ab′)2 fragments. These fragments are reduced in the presence of the dithiol complexing agent sodium arsenite to stabilize vicinal dithiols and prevent intermolecular disulfide formation. The Fab′ fragments generated are then converted to thionitrobenzoate (TNB) derivatives. One of the Fab′-TNB derivatives is then reconverted to the Fab′-thiol by reduction with mercaptoethylamine and is mixed with an equimolar amount of the other Fab′-TNB derivative to form the bispecific antibody. The bispecific antibodies produced can be used as agents for the selective immobilization of enzymes.
Additionally, Fab′ fragments can be directly recovered from E. coli and chemically coupled to form bispecific antibodies. Shalaby et al., J. Exp. Med. 175:217-225 (1992) describe the production of a fully humanized bispecific antibody F(ab′)2 molecule. Each Fab′ fragment was separately secreted from E. coli and subjected to directed chemical coupling in vitro to form the bispecific antibody. The bispecific antibody thus formed was able to bind to cells overexpressing the ErbB2 receptor and normal human T cells, as well as trigger the lytic activity of human cytotoxic lymphocytes against human breast tumor targets.
Various techniques for making and isolating bispecific antibody fragments directly from recombinant cell culture have also been described. For example, bispecific antibodies have been produced using leucine zippers. Kostelny et al., J. Immunol. 148:1547-1553 (1992). The leucine zipper peptides from the Fos and Jun proteins were linked to the Fab′ portions of two different antibodies by gene fusion. The antibody homodimers were reduced at the hinge region to form monomers and then re-oxidized to form the antibody heterodimers. This method can also be utilized for the production of antibody homodimers. The “diabody” technology described by Hollinger et al., Proc. Natl. Acad. Sci. USA 90:6444-6448 (1993) has provided an alternative mechanism for making bispecific antibody fragments. The fragments comprise a heavy-chain variable domain (VH) connected to a light-chain variable domain (VL) by a linker which is too short to allow pairing between the two domains on the same chain. Accordingly, the VH and VL domains of one fragment are forced to pair with the complementary VL and VH domains of another fragment, thereby forming two antigen-binding sites. Another strategy for making bispecific antibody fragments by the use of single-chain Fv (sFv) dimers has also been reported. See, Gruber et al., J. Immunol. 152:5368 (1994).
Antibodies with more than two valencies are contemplated. For example, trispecific antibodies can be prepared. Tutt et al., J. Immunol. 147:60 (1991).
Exemplary bispecific antibodies can bind to two different epitopes, at least one of which originates in the protein antigen of the invention. Alternatively, an anti-antigenic arm of an immunoglobulin molecule can be combined with an arm which binds to a triggering molecule on a leukocyte such as a T-cell receptor molecule (e.g. CD2, CD3, CD28, or B7), or Fc receptors for IgG (FcγR), such as FcγRI (CD64), FcγRII (CD32) and FcγRIII (CD16) so as to focus cellular defense mechanisms to the cell expressing the particular antigen. Bispecific antibodies can also be used to direct cytotoxic agents to cells which express a particular antigen. These antibodies possess an antigen-binding arm and an arm which binds a cytotoxic agent or a radionuclide chelator, such as EOTUBE, DPTA, DOTA, or TETA. Another bispecific antibody of interest binds the protein antigen described herein and further binds tissue factor (TF).
5.12.7 Heteroconjugate Antibodies
Heteroconjugate antibodies are also within the scope of the present invention. Heteroconjugate antibodies are composed of two covalently joined antibodies. Such antibodies have, for example, been proposed to target immune system cells to unwanted cells (U.S. Pat. No. 4,676,980), and for treatment of HIV infection (WO 91/00360; WO 92/200373; EP 03089). It is contemplated that the antibodies can be prepared in vitro using known methods in synthetic protein chemistry, including those involving crosslinking agents. For example, immunotoxins can be constructed using a disulfide exchange reaction or by forming a thioether bond. Examples of suitable reagents for this purpose include iminothiolate and methyl-4-mercaptobutyrimidate and those disclosed, for example, in U.S. Pat. No. 4,676,980.
5.12.8 Effector Function Engineering
It can be desirable to modify the antibody of the invention with respect to effector function, so as to enhance, e.g., the effectiveness of the antibody in treating cancer. For example, cysteine residue(s) can be introduced into the Fc region, thereby allowing interchain disulfide bond formation in this region. The homodimeric antibody thus generated can have improved internalization capability and/or increased complement-mediated cell killing and antibody-dependent cellular cytotoxicity (ADCC). See Caron et al., J. Exp Med., 176: 1191-1195 (1992) and Shopes, J. Immunol., 148: 2918-2922 (1992). Homodimeric antibodies with enhanced anti-tumor activity can also be prepared using heterobifunctional cross-linkers as described in Wolff et al. Cancer Research, 53: 2560-2565 (1993). Alternatively, an antibody can be engineered that has dual Fc regions and can thereby have enhanced complement lysis and ADCC capabilities. See Stevenson et al., Anti-Cancer Drug Design, 3: 219-230 (1989).
5.12.9 Immunoconjugates
The invention also pertains to immunoconjugates comprising an antibody conjugated to a cytotoxic agent such as a chemotherapeutic agent, toxin (e.g., an enzymatically active toxin of bacterial, fungal, plant, or animal origin, or fragments thereof), or a radioactive isotope (i.e., a radioconjugate).
Chemotherapeutic agents useful in the generation of such immunoconjugates have been described above. Enzymatically active toxins and fragments thereof that can be used include diphtheria A chain, nonbinding active fragments of diphtheria toxin, exotoxin A chain (from Pseudomonas aeruginosa), ricin A chain, abrin A chain, modeccin A chain, alpha-sarcin, Aleurites fordii proteins, dianthin proteins, Phytolaca americana proteins (PAPI, PAPII, and PAP-S), momordica charantia inhibitor, curcin, crotin, sapaonaria officinalis inhibitor, gelonin, mitogellin, restrictocin, phenomycin, enomycin, and the tricothecenes. A variety of radionuclides are available for the production of radioconjugated antibodies. Examples include 212Bi, 131I, 131In, 90Y, and 186Re.
Conjugates of the antibody and cytotoxic agent are made using a variety of bifunctional protein-coupling agents such as N-succinimidyl-3-(2-pyridyldithiol) propionate (SPDP), iminothiolane (IT), bifunctional derivatives of imidoesters (such as dimethyl adipimidate HCL), active esters (such as disuccinimidyl suberate), aldehydes (such as glutareldehyde), bis-azido compounds (such as bis (p-azidobenzoyl) hexanediamine), bis-diazonium derivatives (such as bis-(p-diazoniumbenzoyl)-ethylenediamine), diisocyanates (such as tolyene 2,6-diisocyanate), and bis-active fluorine compounds (such as 1,5-difluoro-2,4-dinitrobenzene). For example, a ricin immunotoxin can be prepared as described in Vitetta et al., Science, 238: 1098 (1987). Carbon-14-labeled 1-isothiocyanatobenzyl-3-methyldiethylene triaminepentaacetic acid (MX-DTPA) is an exemplary chelating agent for conjugation of radionucleotide to the antibody. See WO94/11026. In another embodiment, the antibody can be conjugated to a “receptor” (such streptavidin) for utilization in tumor pretargeting wherein the antibody-receptor conjugate is administered to the patient, followed by removal of unbound conjugate from the circulation using a claring agent and then administration of a “ligand” (e.g., avidin) that is in turn conjugated to a cytotoxic agent.
5.13 Assays for Detection of Polypeptides and Polynucleotides of the Invention
5.13.1 Sample Collection and Processing
The polypeptides of the invention individually or in combination are preferably quantified in a biological sample obtained from a patient. In the same manner, polynucleotides of the invention individually or in combination are prefereably quantified in a biological sample obtained from a patient. As used herein, a biological sample is a sample of biological tissue or fluid that contains a concentration of any of the polypeptides or polynucleotides of the invention that may be correlated with blood or tissue levels of any of the polypeptides or polynucleotides of the invention. Particularly preferred biological samples include blood serum (blood lacking a cellular component and clotting factors), blood plasma (blood lacking a cellular component), urine, cervicovaginal mucous, amniotic fluid, or fetal cells.
In one preferred embodiment, the polypeptides of the invention individually or in combination are quantified in whole blood or blood derivatives such as blood plasma or blood serum. Said samples are isolated from a patient according to standard methods well known to those of skill in the art, including venipuncture. After blood isolation from the patient, the blood sample may either be pretreated by dilution in an appropriate buffer solution, or be concentrated. Any of a number of standard aqueous buffer solutions at physiological pH may be employed, including phosphate, Tris, or others. Means of preparing blood serum or blood plasma are well known to those skilled in the art and typically involve centrifugation or filtration to produce blood plasma, or clotting followed by centrifugation or filtration to produce blood serum. Blood plasma or serum may be diluted by the addition of buffers or other reagents well known to those of skill in the art, and may be stored for up to 24 hours at 2-8° C., or at −20° C. or lower for longer periods, prior to measurement of any of the polypeptides of the invention individually or in combination.
In another preferred embodiment, any of the polynucleotides of the invention individually or in combination are quantified from cells present in the amniotic fluid. Said samples are isolated from the pregnant patient according to standard methods well known to those of skill in the art, including amniocentesis. Preferably within the second trimester of pregnancy, a thin, hollow needle is inserted from the abdomen through the uterus into the amniotic sac. A small amount (approximately 1 or 2 tablespoons) of amniotic fluid is withdrawn, with the needle then being removed. Subsequently, living cells from the withdrawn amniotic fluid are cultured for approximately two weeks before quantification of expression of any of the polynucleotides of the invention individually or in combination.
In another preferred embodiment, any of the polypeptides of the invention individually or in combination are quantified from vaginal mucous. Cervicovaginal mucous is removed from an area within the vaginal cavity such as the posterior formix, cervical canal, or uterine cavity. The sample is removed with a swab having a fibrous tip, aspirator, suction device, lavage device or the like and transferred to a suitable container for storage and transport to the testing laboratory. It is important that the sample be dispersed in a liquid that preserves the sensitive protein analytes such as any of the polypeptides of the invention which may be unstable in the sampled composition. The storage and transfer medium should prevent decline in the protein analyte level during storage and transfer. One example of a suitable preserving solution for storage and transfer consists of 0.05M Tris-HCL, pH 7.4; 0.15M NaCl, 0.02% NaN3, 1% BSA, 500 Kallikrein Units/mL aprotinin, 1 mM phenylmethylsulfonyl fluoride (PMSF) and 5 mM EDTA.
In another preferred embodiment, any of the polypeptides of the invention individually or in combination are quantified from a sample of urine from a patient during pregnancy. The sample can be taken from any time of day, but preferably from the first morning void. One example of urine specimen collection and storage includes having the patient void into a plastic urine specimen container, and then immediately storing the container with the urine sample at 2 to 30° C. until testing. If the sample is to be stored for longer than 30 days, then it should be frozen between −20 and −70° C. until testing.
In another preferred embodiment, any of the polynucleotides of the invention individually or in combination are quantified from a sample of fetal cells and/or maternal cells derived from maternal blood. Fetal cell isolation from samples of maternal blood is achieved using any number of well-recognized detection and isolation techniques. (See for example Clin Chem Lab Med. 2002 February; 40(2):126-31, Int J Mol Med. 2002 September; 10(3):257-61, Cytometry. 2001 Dec. 1;45(4):267-76, and Expert Rev Mol Diagn. 2002 Jul.; 2(4):303-11 which are hereby incorporated by reference). Isolation of maternal blood cells is well-known to those of skill in the art.
5.13.2 Quantification of the Polypeptides of the Invention
Any of the polypeptides of the invention individually or in combination may be detected and quantified by any of a number of means well known to those of skill in the art. These may include analytic biochemical methods such as electrophoresis, capillary electrophoresis, high performance liquid chromatography (HPLC), thin layer chromatography (TLC), hyperdiffusion chromatography, by surface-enhanced laser desorption/ionization (SELDI), and the like, or various immunological methods such as fluid or gel precipitation reactions, immunodiffusion (single or double), immunoelectrophoresis, radioimmunoassay (RIA), enzyme-linked immunosorbent assays (ELISAs), immunofluorescent assays, western blotting, and the like.
As used herein, an immunoassay is an assay that utilizes an antibody to specifically bind to the analyte. The immunoassay is characterized by the use of specific binding to a particular antibody as opposed to other physical or chemical properties to isolate, target, and quantify the analyte.
5.13.3 Immunological Binding Assays
In a preferred embodiment, any of the polypeptides of the invention individually or in combination may be detected and quantified using any of a number of well-recognized immunological binding assays. (See for example, U.S. Pat. No. 5,712,103 hereby incorporated herein by reference.) For a review of the general immunoassays, see also Methods in Cell Biology Volume 37: Antibodies in Cell Biology, Asai, ed. Academic Press, Inc. N.Y. (1993); Basic and Clinical Immunology 7th Edition, Stites & Terr, eds. (1991), which are hereby incorporated herein by reference.
Immunological binding assays (or immunoassays) typically utilize a “capture agent” to specifically bind to and often immobilize the analyte (in this case any of the polypeptides of the invention). The capture agent is a moiety that specifically binds to the analyte. In a preferred embodiment, the capture agent is an antibody that specifically binds one of the polypeptides of the invention.
The antibody may be provided by any of a number of means well known to those of skill in the art (see, for example Methods in Cell Biology Vol. 37: Antibodies in Cell Biology, Asai, ed. Academic Press, Inc. N.Y. (1993); and Basic and Clinical Immunology 7th Edition, Stites & Terr, eds. (1991), which are hereby incorporated herein by reference). The antibody may be a whole antibody or an antibody fragment. It may be polyclonal or monoclonal, and it may be produced by challenging an organism (e.g. mouse, rat, rabbit, etc.) with any of the polypeptides of the invention or an epitope derived therefrom. Alternatively, the antibody may be produced de novo using recombinant DNA methodology (e.g. DNA vaccination) and any of the polynucleotides of the invention in full-length gene form or a fragment derived therefrom. Additionally, antibodies that specifically bind any of the polypeptides of the invention may be produced using standard methods well-known to those of skill in the art, or may be obtained commercially.
Immunoassays also often utilize a labeling agent to specifically bind to and label the binding complex formed by the capture agent and the analyte. The labeling agent may itself be one of the moieties comprising the antibody/analyte complex. Thus, the labeling agent may be a labeled version of any of the polypeptides of the invention or a labeled antibody selectively recognizing any of the polypeptides of the invention. Alternatively, the labeling agent may be a third moiety, such as another antibody, that specifically binds to an antibody complexed with a polypeptide of the invention.
In a preferred embodiment, the labeling agent is an antibody that specifically binds to the capture agent (the antibody specifically recognizing any of the polypeptides of the invention). Such agents are well known to those of skill in the art, and most typically comprise labeled antibodies that specifically bind antibodies of the particular animal species from which the capture agent is derived. Thus, for example, where the capture agent is rabbit derived anti-human antibody to any of the polypeptides of the invention, the label agent may be a goat anti-rabbit IgG; an antibody that is specific to the constant region of the rabbit antibody.
Other proteins capable of specifically binding immunoglobulin constant regions, such as protein A or protein G may also be used as the label agent. These proteins are normal constituents of the cell walls of streptococcal bacteria. They exhibit a strong non-immunogenic reactivity with immunoglobulin constant regions from a variety of species.
Throughout the assays, incubation and/or washing steps may be required after each combination of reagents. Incubation steps can vary from about 5 seconds to several hours, preferably from about 5 minutes to 24 hours. However, the incubation time will depend upon the assay format, analyte, volume of solution, concentration, and the like. Usually, the assays will be carried out at ambient temperature, although they can be conducted over a range of temperatures, such as 10° C. to 40° C.
5.13.4 Non-Competitive Assay Formats
Immunoassays for detecting any of the polypeptides of the invention may be either competitive or noncompetitive. Noncompetitive immunoassays are assays in which the amount of captured analyte (in this case any of the polypeptides of the invention) is directly measured. In one preferred “sandwich” assay, for example, the capture agent (antibodies selective for any of the polypeptides of the invention) can be bound directly to a solid substrate where they are immobilized. These immobilized antibodies then capture the protein encoded from any of the polypeptides of the invention present in the test sample. The protein thus immobilized is then bound by a labeling agent, such as a second human antibody selective for any of the polypeptides of the invention bearing a label. Alternatively, the second antibody may lack a label, but it may, in turn, be bound by a labeled third antibody specific to antibodies of the species from which the second antibody is derived.
Sandwich assays are particularly preferred as diagnostics for the present invention. Such an assay provides immobilized antibodies selective for any of the polypeptides of the invention, the polypeptides of the invention concentration standards, 125I labeled antibodies selective for any of the polypeptides of the invention, and positive and negative controls for the polypeptides of the invention. As described above, the immobilized antibodies specifically bind to the the polypeptides of the invention present in the sample. Then the 125I labeled antibodies selective for any of the polypeptides of the invention bind to the already bound polypeptides of the invention. Free 125I labeled antibodies selective for any of the polypeptides of the invention are washed away and the remaining bound 125I labeled antibodies selective for any of the polypeptides of the invention are detected using a gamma detector.
5.13.5 Competitive Assays
In competitive assays, the amount of analyte (any of the polypeptides of the invention) present in the sample is measured indirectly by measuring the amount of an added (exogenous) analyte (the polypeptides of the invention) displaced (or competed away) from a capture agent (antibody selective for the polypeptides of the invention) by the analyte present in the sample. In one competitive assay, a known amount of any of the polypeptides of the invention is added to the sample and the sample is then contacted with a capture agent, in this case an antibody that specifically binds to one of the polypeptides of the invention. The amount of the polypeptides of the invention bound to the antibody is inversely proportional to the concentration of protein present in the sample.
In a particularly preferred embodiment, the antibody is immobilized on a solid substrate. The amount of any of the polypeptides of the invention bound to the antibody may be determined either by measuring the amount of the polypeptides of the invention present in an complex consisting of an antibody specific for the polypeptides of the invention and the corresponding polypeptide of the invention, or alternatively by measuring the amount of remaining uncomplexed polypeptides of the invention. The amount of polypeptides of the invention may be detected by providing a labeled version of nay of the polypeptides of the invention.
A hapten inhibition assay is another preferred competitive assay. In this assay a known analyte, in this case any of the polypeptides of the invention is immobilized on a solid substrate. A known amount of antibody selective for any of the polypeptides of the invention is added to the sample, and the sample is then contacted with the immobilized quantity of the polypeptides of the invention. In this case, the amount of antibody selective for any of the polypeptides of the invention that is bound to the immobilized quantity of any of the polypeptides of the invention is proportional to the amount of actual polypeptides of the invention present in the sample. Again the amount of immobilized antibody may be detected by detecting either the immobilized fraction of antibody or the fraction of the antibody that remains in solution. Detection may be direct wherein the antibody is labeled or indirect by the subsequent addition of a labeled moiety that specifically binds to the antibody as described above.
5.13.6 Reduction of Non-Specific Binding
One of skill in the art will appreciate that it is often desirable to reduce non-specific binding in immunoassays. Particularly, where the assay involves an antigen or antibody immobilized on a solid substrate it is desirable to minimize the amount of non-specific binding to the substrate. Means of reducing such non-specific binding are well known to those of skill in the art. Typically, this involves coating the substrate with a proteinaceous composition. In particular, protein compositions such as bovine serum albumin (BSA), nonfat powdered milk, and gelatin are widely used with powdered milk being most preferred.
5.13.7 Other Assay Formats
Western blot (immunoblot) analysis can also be used to detect and quantify the presence of any of the polypeptides of the invention in the sample. The technique generally comprises separating sample proteins by gel electrophoresis on the basis of molecular weight, transferring the separated proteins to a suitable solid support, (such as a nitrocellulose filter, a nylon filter, or derivatized nylon filter), and incubating the sample with an antibody that specifically binds one of the polypeptides of the invention. These antibodies may be directly labeled or alternatively may be subsequently detected using labeled antibodies (e.g. labeled sheep anti-mouse antibodies) that specifically bind to the antibodies specific for the polypeptides of the invention.
5.13.8 Labels
The particular label or detectable group used in the assay is not a critical aspect of the invention, so long as it does not significantly interfere with the specific binding of the antibody used in the assay. The detectable group can be any material having a detectable physical or chemical property. Such detectable labels have been well-developed in the field of immunoassays and, in general, most any label useful in such methods can be applied to the present invention. Thus, a label is any composition detectable by spectroscopic, photochemical, biochemical, immunochemical, electrical, optical or chemical means. Useful labels in the present invention include magnetic beads (e.g. Dynabeads.™.), fluorescent dyes (e.g., fluorescein isothiocyanate, texas red, rhodamine, and the like), radiolabels (e.g., 3H, 125I, 35S, 14C, or 32P), enzymes (e.g., horseradish peroxidase, alkaline phosphatase and others commonly used in an ELISA), and colorimetric labels such as colloidal gold or colored glass or plastic (e.g. polystyrene, polypropylene, latex, etc.) beads.
The label may be coupled directly or indirectly to the desired component of the assay according to methods well known in the art. As indicated above, a wide variety of labels may be used, with the choice of label depending on sensitivity required, ease of conjugation with the compound, stability requirements, available instrumentation, and disposal provisions.
Non-radioactive labels are often attached by indirect means. Generally, a ligand molecule (e.g., biotin) is covalently bound to the molecule. The ligand then binds to an anti-ligand (e.g., streptavidin) molecule which is either inherently detectable or covalently bound to a signal system, such as a detectable enzyme, a fluorescent compound, or a chemiluminescent compound. A number of ligands and anti-ligands can be used. Where a ligand has a natural anti-ligand, for example, biotin, thyroxine, and cortisol, it can be used in conjunction with the labeled, naturally occurring anti-ligands. Alternatively, any haptenic or antigenic compound can be used in combination with an antibody.
The molecules can also be conjugated directly to signal generating compounds, e.g., by conjugation with an enzyme or fluorophore. Enzymes of interest as labels will primarily be hydrolases, particularly phosphatases, esterases and glycosidases, or oxidoreductases, particularly peroxidases. Fluorescent compounds include fluorescein and its derivatives, rhodamine and its derivatives, dansyl, umbelliferone, etc. Chemiluminescent compounds include luciferin, and 2,3-dihydrophthalazinediones, e.g., luminol. For a review of various labeling or signal producing systems which may be used, see, U.S. Pat. No. 4,391,904, which is hereby incorporated herein by reference.
Means of detecting labels are well known to those of skill in the art. Thus, for example, where the label is a radioactive label, means for detection include a scintillation counter or photographic film as in autoradiography. Where the label is a fluorescent label, it may be detected by exciting the fluorochrome with the appropriate wavelength of light and detecting the resulting fluorescence. The fluorescence may be detected visually, by means of photographic film, by the use of electronic detectors such as charge coupled devices (CCDs) or photomultipliers and the like. Similarly, enzymatic labels may be detected by providing the appropriate substrates for the enzyme and detecting the resulting reaction product. Finally simple colorimetric labels may be detected simply by observing the color associated with the label. Thus, in various dipstick assays, conjugated gold often appears pink, while various conjugated beads appear the color of the bead.
Some assay formats do not require the use of labeled components. For instance, agglutination assays can be used to detect the presence of the target antibodies. In this case, antigen-coated particles are agglutinated by samples comprising the target antibodies. In this format, none of the components need be labeled and the presence of the target antibody is detected by simple visual inspection.
5.13.9 Substrates
As mentioned above, depending upon the assay, various components, including the antigen, target antibody, or anti-human antibody, may be bound to a solid surface. Many methods for immobilizing biomolecules to a variety of solid surfaces are known in the art. For instance, the solid surface may be a membrane (e.g., nitrocellulose), a microtiter dish (e.g., PVC, polypropylene, or polystyrene), a test tube (glass or plastic), a dipstick (e.g. glass, PVC, polypropylene, polystyrene, latex, and the like), a microcentrifuge tube, or a glass or plastic bead. The desired component may be covalently bound or noncovalently attached through nonspecific bonding.
A wide variety of organic and inorganic polymers, both natural and synthetic may be employed as the material for the solid surface. Illustrative polymers include polyethylene, polypropylene, poly(4-methylbutene), polystyrene, polymethacrylate, poly(ethylene terephthalate), rayon, nylon, poly(vinyl butyrate), polyvinylidene difluoride (PVDF), silicones, polyformaldehyde, cellulose, cellulose acetate, nitrocellulose, and the like. Other materials which may be employed, include paper, glasses, ceramics, metals, metalloids, semiconductive materials, cements or the like. In addition, are included substances that form gels, such as proteins (e.g., gelatins), lipopolysaccharides, silicates, agarose and polyacrylamides can be used. Polymers which form several aqueous phases, such as dextrans, polyalkylene glycols or surfactants, such as phospholipids, long chain (12-24 carbon atoms) alkyl ammonium salts and the like are also suitable. Where the solid surface is porous, various pore sizes may be employed depending upon the nature of the system.
In preparing the surface, a plurality of different materials may be employed, particularly as laminates, to obtain various properties. For example, protein coatings, such as gelatin can be used to avoid non-specific binding, simplify covalent conjugation, enhance signal detection or the like.
If covalent bonding between a compound and the surface is desired, the surface will usually be polyfunctional or be capable of being polyfunctionalized. Functional groups which may be present on the surface and used for linking can include carboxylic acids, aldehydes, amino groups, cyano groups, ethylenic groups, hydroxyl groups, mercapto groups and the like. The manner of linking a wide variety of compounds to various surfaces is well known and is amply illustrated in the literature. See, for example, Cuatrecasas, J. Biol. Chem. 245 3059 (1970) which is hereby incorporated herein by reference.
In addition to covalent bonding, various methods for noncovalently binding an assay component can be used. Noncovalent binding is typically nonspecific absorption of a compound to the surface. Typically, the surface is blocked with a second compound to prevent nonspecific binding of labeled assay components. Alternatively, the surface is designed such that it nonspecifically binds one component but does not significantly bind another. For example, a surface bearing a lectin such as Concanavalin A will bind a carbohydrate containing compound but not a labeled protein that lacks glycosylation. Various solid surfaces for use in noncovalent attachment of assay components are reviewed in U.S. Pat. Nos. 4,447,576 and 4,254,082, which are hereby incorporated herein by reference.
5.13.10 Mass Spectrometry
Levels of polypeptides can be detected also by mass spectrometry. Detection of disease biomarkers using mass spectrometry with protein biochip analysis is well known to those of skill in the art, and is detailed in: Rosty et al. Cancer Research 62: 1868 (2002), and Qu et al. Expert Rev Mol Diagn 2: 549 (2002), and are hereby incorporated herein by reference.
5.13.11 Determination of Levels of the Polypeptides of the Invention for Prediction of Preeclampsia
The preeclamptic condition is predicted by a statistically significant change in the concentration of any of the polypeptides of the invention individually or in combination in maternal blood, urine, or cervicovaginal mucous during pregnancy. Thus, the levels of any of the polypeptides of the invention individually or in combination provide an advantageous diagnostic of preeclampsia.
Baseline healthy levels of any of the polypeptides of the invention individually or in combination and levels indicative of preeclampsia may be determined by means well known to those of skill in the art. Generally this simply involves routine screening of healthy patients and patients that ultimately develop preeclampsia. Any variation between the two patient populations in the polypeptides of the invention individually or in combination that is determined by time of gestation, may be controlled by sampling uniformly at approximately the same gestational period, or alternatively, by determining blood, urine, or cervicovaginal mucous levels of the polypeptides of the invention (individually or in combination) as a function of period of gestation.
5.13.12 Quantification of the Polynucleotides of the Invention
Levels of any of the polynucleotides of the invention individually or in combination may be detected and quantified from tissue samples by any of a number of means well known to those of skill in the art. These may include analytic methods or techniques such as microarrays, PCR (polymerase chain reaction), RT-PCR (reverse transcriptase PCR), real-time PCR, TaqMan (Applied Biosystems), or Northern analysis.
5.14 Diagnostic Kits
5.14.1 Diagnostic Kits for Detection or Prediction of Preeclampsia Using any of the Polypeptides of the invention Individually or in Combination
The present invention provides for kits for the diagnosis of women at risk for preeclampsia. The kits preferably include one or more antibodies that specifically bind to the polypeptides of the invention. The antibodies may be free or immobilized on a solid support such as a test tube, a microtiter plate, a dipstick and the like. The kit may also contain instructional materials teaching the use of the antibody in an assay for the detection of a predilection to preeclampsia.
Additionally, the kit may contain one or more second antibodies that specifically bind to one of the polypeptides of the invention or alternatively, the first antibody. The second antibody may be labeled, or alternatively, the kit may contain a labeled third antibody that specifically binds the second antibody. The kit may also contain appropriate control series of any of the polypeptides of the invention, buffer solutions, positive and negative controls, washing solutions, dilution buffers and the like for the preparation and analysis of any of the polypeptides of the invention in samples derived from tissues, including blood plasma, blood serum, urine, or cervicovaginal mucous.
5.14.2 Diagnostic Kits for Detection or Prediction of Preeclampsia Using any of the Polynucleotides of the Invention Individually or in Combination
The present invention also provides for kits for the diagnosis of women at risk for preeclampsia. The kits preferably include one or more pairs of primers that specifically hybridize to the polynucleotides of the invention plus reagents well known to those of skill in the art for polymerase chain reaction (PCR) amplification of the polynucleotides of the invention, for example Medhurst et al. Methods Mol Med. 2003;79:229 and Dotsch et al. Expert Rev Mol Diagn. 2001 Jul.; 1(2):233.
Another preferred embodiment of the diagnostic kit for detection of preeclampsia using polynucleotides of the invention individually or in combination, is a microarray detection kit. Said microarray is comprised of a solid surface onto which single or double stranded polynucleotides of the invention are chemically or physically bonded or attached. Detection of levels of the polynucleotides of the invention are quantified by hybidization of the polynucleotides of the invention derived from tissue samples with like polynucleotides of the invention attached onto said solid surface. Either the polynucleotides of the invention derived from tissues or attached onto the solid surface may be attached to a detection label, for example Cy3 or Cy5 dyes (Amersham, Piscataway, N.J.). Microarray techniques are well known to those of skill in the art, and are detailed in Iyer V R, et al. (1999) Science 283(5398):83-7 and Whitney A R, et al. (2003). Proc Natl Acad Sci USA 100(4): 1896-901, hereby incorporated herein by reference.
5.15 Therapeutic Methods
The compositions (including polypeptide fragments, analogs, variants and antibodies or other binding partners or modulators including antisense polynucleotides) of the invention have applications in the treatment of preeclampsia.
5.15.1 Example
One embodiment of the invention is the administration of an effective amount of the one or more of the polypeptides or other composition of the invention to individuals affected by preeclampsia that can be modulated by regulating the peptides of the invention. While the mode of administration is not particularly important, parenteral administration is preferred. An exemplary mode of administration is to deliver an intravenous bolus. The dosage of polypeptides of the invention or other composition of the invention will normally be determined by the prescribing physician. It is to be expected that the dosage will vary according to the age, weight, condition and response of the individual patient. Typically, the amount of polypeptide administered per dose will be in the range of about 0.01 μg/kg to 100 mg/kg of body weight, with the preferred dose being about 0.1 μg/kg to 10 mg/kg of patient body weight. For parenteral administration, polypeptides of the invention or other composition of the invention will be formulated in an injectable form combined with a pharmaceutically acceptable parenteral vehicle. Such vehicles are well known in the art and examples include water, saline, Ringer's solution, dextrose solution, and solutions consisting of small amounts of the human serum albumin. The vehicle may contain minor amounts of additives that maintain the isotonicity and stability of the polypeptide or other active ingredient. The preparation of such solutions is within the skill of the art.
5.16 Pharmaceutical Formulations and Routes of Administration
A polypeptide or other composition of the present invention (from whatever source derived, including without limitation from recombinant and non-recombinant sources and including antibodies and other binding partners of the polypeptides of the invention) may be administered to a patient in need, by itself, or in pharmaceutical compositions where it is mixed with suitable carriers or excipient(s) at doses to treat or ameliorate a variety of disorders. Such a composition may optionally contain (in addition to protein or other active ingredient and a carrier) diluents, fillers, salts, buffers, stabilizers, solubilizers, and other materials well known in the art. The term “pharmaceutically acceptable” means a non-toxic material that does not interfere with the effectiveness of the biological activity of the active ingredient(s). The characteristics of the carrier will depend on the route of administration. The pharmaceutical composition of the invention may also contain cytokines, lymphokines, or other hematopoietic factors such as M-CSF, GM-CSF, TNF, IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IFN, TNF0, TNF1, TNF2, G-CSF, Meg-CSF, thrombopoietin, stem cell factor, and erythropoietin. In further compositions, proteins of the invention may be combined with other agents beneficial to the treatment of the disease or disorder in question. These agents include various growth factors such as epidermal growth factor (EGF), platelet-derived growth factor (PDGF), transforming growth factors (TGF-α and TGF-β), insulin-like growth factor (IGF), as well as cytokines described herein.
The pharmaceutical composition may further contain other agents which either enhance the activity of the protein or other active ingredient or complement its activity or use in treatment. Such additional factors and/or agents may be included in the pharmaceutical composition to produce a synergistic effect with protein or other active ingredient of the invention, or to minimize side effects. Conversely, protein or other active ingredient of the present invention may be included in formulations of the particular clotting factor, cytokine, lymphokine, other hematopoietic factor, thrombolytic or anti-thrombotic factor, or anti-inflammatory agent to minimize side effects of the clotting factor, cytokine, lymphokine, other hematopoietic factor, thrombolytic or anti-thrombotic factor, or anti-inflammatory agent (such as IL-IRa, IL-1 Hy1, IL-1 Hy2, anti-TNF, corticosteroids, immunosuppressive agents). A protein of the present invention may be active in multimers (e.g., heterodimers or homodimers) or complexes with itself or other proteins. As a result, pharmaceutical compositions of the invention may comprise a protein of the invention in such multimeric or complexed form.
As an alternative to being included in a pharmaceutical composition of the invention including a first protein, a second protein or a therapeutic agent may be concurrently administered with the first protein (e.g., at the same time, or at differing times provided that therapeutic concentrations of the combination of agents is achieved at the treatment site). Techniques for formulation and administration of the compounds of the instant application may be found in “Remington's Pharmaceutical Sciences,” Mack Publishing Co., Easton, Pa., latest edition. A therapeutically effective dose further refers to that amount of the compound sufficient to result in amelioration of symptoms, e.g., treatment, healing, prevention or amelioration of the relevant medical condition, or an increase in rate of treatment, healing, prevention or amelioration of such conditions. When applied to an individual active ingredient, administered alone, a therapeutically effective dose refers to that ingredient alone. When applied to a combination, a therapeutically effective dose refers to combined amounts of the active ingredients that result in the therapeutic effect, whether administered in combination, serially or simultaneously.
In practicing the method of treatment or use of the present invention, a therapeutically effective amount of protein or other active ingredient of the present invention is administered to a mammal having a condition to be treated. Protein or other active ingredient of the present invention may be administered in accordance with the method of the invention either alone or in combination with other therapies such as treatments employing cytokines, lymphokines or other hematopoietic factors. When co-administered with one or more cytokines, lymphokines or other hematopoietic factors, protein or other active ingredient of the present invention may be administered either simultaneously with the cytokine(s), lymphokine(s), other hematopoietic factor(s), thrombolytic or anti-thrombotic factors, or sequentially. If administered sequentially, the attending physician will decide on the appropriate sequence of administering protein or other active ingredient of the present invention in combination with cytokine(s), lymphokine(s), other hematopoietic factor(s), thrombolytic or anti-thrombotic factors.
5.16.1 Routes of Administration
Suitable routes of administration may, for example, include oral, rectal, transmucosal, or intestinal administration; parenteral delivery, including intramuscular, subcutaneous, intramedullary injections, as well as intrathecal, direct intraventricular, intravenous, intraperitoneal, intranasal, or intraocular injections. Administration of protein or other active ingredient of the present invention used in the pharmaceutical composition or to practice the method of the present invention can be carried out in a variety of conventional ways, such as oral ingestion, inhalation, topical application or cutaneous, subcutaneous, intraperitoneal, parenteral or intravenous injection. Intravenous administration to the patient is preferred.
Alternately, one may administer the compound in a local rather than systemic manner, for example, via injection of the compound directly into the amniotic cavity or placental tissue, often in a depot or sustained release formulation. Furthermore, one may administer the drug in a targeted drug delivery system, for example, in a liposome coated with a specific antibody, targeting, for example, placental tissue. The liposomes will be targeted to and taken up selectively by the afflicted tissue.
The polypeptides of the invention are administered by any route that delivers an effective dosage to the desired site of action. The determination of a suitable route of administration and an effective dosage for a particular indication is within the level of skill in the art. Suitable dosage ranges for the polypeptides of the invention can be extrapolated from these dosages or from similar studies in appropriate animal models. Dosages can then be adjusted as necessary by the clinician to provide maximal therapeutic benefit.
5.16.2 Compositions and Formulations
Pharmaceutical compositions for use in accordance with the present invention thus may be formulated in a conventional manner using one or more physiologically acceptable carriers comprising excipients and auxiliaries which facilitate processing of the active compounds into preparations which can be used pharmaceutically. These pharmaceutical compositions may be manufactured in a manner that is itself known, e.g., by means of conventional mixing, dissolving, granulating, dragee-making, levigating, emulsifying, encapsulating, entrapping or lyophilizing processes. Proper formulation is dependent upon the route of administration chosen. When a therapeutically effective amount of protein or other active ingredient of the present invention is administered orally, protein or other active ingredient of the present invention will be in the form of a tablet, capsule, powder, solution or elixir. When administered in tablet form, the pharmaceutical composition of the invention may additionally contain a solid carrier such as a gelatin or an adjuvant. The tablet, capsule, and powder contain from about 5 to 95% protein or other active ingredient of the present invention, and preferably from about 25 to 90% protein or other active ingredient of the present invention. When administered in liquid form, a liquid carrier such as water, petroleum, oils of animal or plant origin such as peanut oil, mineral oil, soybean oil, or sesame oil, or synthetic oils may be added. The liquid form of the pharmaceutical composition may further contain physiological saline solution, dextrose or other saccharide solution, or glycols such as ethylene glycol, propylene glycol or polyethylene glycol. When administered in liquid form, the pharmaceutical composition contains from about 0.5 to 90% by weight of protein or other active ingredient of the present invention, and preferably from about 1 to 50% protein or other active ingredient of the present invention.
When a therapeutically effective amount of protein or other active ingredient of the present invention is administered by intravenous, cutaneous or subcutaneous injection, protein or other active ingredient of the present invention will be in the form of a pyrogen-free, parenterally acceptable aqueous solution. The preparation of such parenterally acceptable protein or other active ingredient solutions, having due regard to pH, isotonicity, stability, and the like, is within the skill in the art. A preferred pharmaceutical composition for intravenous, cutaneous, or subcutaneous injection should contain, in addition to protein or other active ingredient of the present invention, an isotonic vehicle such as Sodium Chloride Injection, Ringer's Injection, Dextrose Injection, Dextrose and Sodium Chloride Injection, Lactated Ringer's Injection, or other vehicle as known in the art. The pharmaceutical composition of the present invention may also contain stabilizers, preservatives, buffers, antioxidants, or other additives known to those of skill in the art. For injection, the agents of the invention may be formulated in aqueous solutions, preferably in physiologically compatible buffers such as Hanks's solution, Ringer's solution, or physiological saline buffer. For transmucosal administration, penetrants appropriate to the barrier to be permeated are used in the formulation. Such penetrants are generally known in the art.
For oral administration, the compounds can be formulated readily by combining the active compounds with pharmaceutically acceptable carriers well known in the art. Such carriers enable the compounds of the invention to be formulated as tablets, pills, dragees, capsules, liquids, gels, syrups, slurries, suspensions and the like, for oral ingestion by a patient to be treated. Pharmaceutical preparations for oral use can be obtained solid excipient, optionally grinding a resulting mixture, and processing the mixture of granules, after adding suitable auxiliaries, if desired, to obtain tablets or dragee cores. Suitable excipients are, in particular, fillers such as sugars, including lactose, sucrose, mannitol, or sorbitol; cellulose preparations such as, for example, maize starch, wheat starch, rice starch, potato starch, gelatin, gum tragacanth, methyl cellulose, hydroxypropylmethyl-cellulose, sodium carboxymethylcellulose, and/or polyvinylpyrrolidone (PVP). If desired, disintegrating agents may be added, such as the cross-linked polyvinyl pyrrolidone, agar, or alginic acid or a salt thereof such as sodium alginate. Dragee cores are provided with suitable coatings. For this purpose, concentrated sugar solutions may be used, which may optionally contain gum arabic, talc, polyvinyl pyrrolidone, carbopol gel, polyethylene glycol, and/or titanium dioxide, lacquer solutions, and suitable organic solvents or solvent mixtures. Dyestuffs or pigments may be added to the tablets or dragee coatings for identification or to characterize different combinations of active compound doses.
Pharmaceutical preparations which can be used orally include push-fit capsules made of gelatin, as well as soft, sealed capsules made of gelatin and a plasticizer, such as glycerol or sorbitol. The push-fit capsules can contain the active ingredients in admixture with filler such as lactose, binders such as starches, and/or lubricants such as talc or magnesium stearate and, optionally, stabilizers. In soft capsules, the active compounds may be dissolved or suspended in suitable liquids, such as fatty oils, liquid paraffin, or liquid polyethylene glycols. In addition, stabilizers may be added. All formulations for oral administration should be in dosages suitable for such administration. For buccal administration, the compositions may take the form of tablets or lozenges formulated in conventional manner.
For administration by inhalation, the compounds for use according to the present invention are conveniently delivered in the form of an aerosol spray presentation from pressurized packs or a nebuliser, with the use of a suitable propellant, e.g., dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas. In the case of a pressurized aerosol the dosage unit may be determined by providing a valve to deliver a metered amount. Capsules and cartridges of, e.g., gelatin for use in an inhaler or insufflator may be formulated containing a powder mix of the compound and a suitable powder base such as lactose or starch. The compounds may be formulated for parenteral administration by injection, e.g., by bolus injection or continuous infusion. Formulations for injection may be presented in unit dosage form, e.g., in ampules or in multi-dose containers, with an added preservative. The compositions may take such forms as suspensions, solutions or emulsions in oily or aqueous vehicles, and may contain formulatory agents such as suspending, stabilizing and/or dispersing agents.
Pharmaceutical formulations for parenteral administration include aqueous solutions of the active compounds in water-soluble form. Additionally, suspensions of the active compounds may be prepared as appropriate oily injection suspensions. Suitable lipophilic solvents or vehicles include fatty oils such as sesame oil, or synthetic fatty acid esters, such as ethyl oleate or triglycerides, or liposomes. Aqueous injection suspensions may contain substances which increase the viscosity of the suspension, such as sodium carboxymethyl cellulose, sorbitol, or dextran. Optionally, the suspension may also contain suitable stabilizers or agents which increase the solubility of the compounds to allow for the preparation of highly concentrated solutions. Alternatively, the active ingredient may be in powder form for constitution with a suitable vehicle, e.g., sterile pyrogen-free water, before use.
The compounds may also be formulated in rectal compositions such as suppositories or retention enemas, e.g., containing conventional suppository bases such as cocoa butter or other glycerides. In addition to the formulations described previously, the compounds may also be formulated as a depot preparation. Such long acting formulations may be administered by implantation (for example subcutaneously or intramuscularly) or by intramuscular injection. Thus, for example, the compounds may be formulated with suitable polymeric or hydrophobic materials (for example as an emulsion in an acceptable oil) or ion exchange resins, or as sparingly soluble derivatives, for example, as a sparingly soluble salt.
A pharmaceutical carrier for the hydrophobic compounds of the invention is a co-solvent system comprising benzyl alcohol, a nonpolar surfactant, a water-miscible organic polymer, and an aqueous phase. The co-solvent system may be the VPD co-solvent system. VPD is a solution of 3% w/v benzyl alcohol, 8% w/v of the nonpolar surfactant polysorbate 80, and 65% w/v polyethylene glycol 300, made up to volume in absolute ethanol. The VPD co-solvent system (VPD:5W) consists of VPD diluted 1:1 with a 5% dextrose in water solution. This co-solvent system dissolves hydrophobic compounds well, and itself produces low toxicity upon systemic administration. Naturally, the proportions of a co-solvent system may be varied considerably without destroying its solubility and toxicity characteristics. Furthermore, the identity of the co-solvent components may be varied: for example, other low-toxicity nonpolar surfactants may be used instead of polysorbate 80; the fraction size of polyethylene glycol may be varied; other biocompatible polymers may replace polyethylene glycol, e.g. polyvinyl pyrrolidone; and other sugars or polysaccharides may substitute for dextrose. Alternatively, other delivery systems for hydrophobic pharmaceutical compounds may be employed. Liposomes and emulsions are well known examples of delivery vehicles or carriers for hydrophobic drugs. Certain organic solvents such as dimethylsulfoxide also may be employed, although usually at the cost of greater toxicity. Additionally, the compounds may be delivered using a sustained-release system, such as semipermeable matrices of solid hydrophobic polymers containing the therapeutic agent. Various types of sustained-release materials have been established and are well known by those skilled in the art. Sustained-release capsules may, depending on their chemical nature, release the compounds for a few weeks up to over 100 days. Depending on the chemical nature and the biological stability of the therapeutic reagent, additional strategies for protein or other active ingredient stabilization may be employed.
The pharmaceutical compositions also may comprise suitable solid or gel phase carriers or excipients. Examples of such carriers or excipients include but are not limited to calcium carbonate, calcium phosphate, various sugars, starches, cellulose derivatives, gelatin, and polymers such as polyethylene glycols. Many of the active ingredients of the invention may be provided as salts with pharmaceutically compatible counter ions. Such pharmaceutically acceptable base addition salts are those salts which retain the biological effectiveness and properties of the free acids and which are obtained by reaction with inorganic or organic bases such as sodium hydroxide, magnesium hydroxide, ammonia, trialkylamine, dialkylamine, monoalkylamine, dibasic amino acids, sodium acetate, potassium benzoate, triethanol amine and the like.
The pharmaceutical composition of the invention may be in the form of a complex of the protein(s) or other active ingredient of present invention along with protein or peptide antigens. The protein and/or peptide antigen will deliver a stimulatory signal to both B and T lymphocytes. B lymphocytes will respond to antigen through their surface immunoglobulin receptor. T lymphocytes will respond to antigen through the T cell receptor (TCR) following presentation of the antigen by NMC proteins. MHC and structurally related proteins including those encoded by class I and class II MHC genes on host cells will serve to present the peptide antigen(s) to T lymphocytes. The antigen components could also be supplied as purified MHC-peptide complexes alone or with co-stimulatory molecules that can directly signal T cells. Alternatively antibodies able to bind surface immunoglobulin and other molecules on B cells as well as antibodies able to bind the TCR and other molecules on T cells can be combined with the pharmaceutical composition of the invention.
The pharmaceutical composition of the invention may be in the form of a liposome in which protein of the present invention is combined, in addition to other pharmaceutically acceptable carriers, with amphipathic agents such as lipids which exist in aggregated form as micelles, insoluble monolayers, liquid crystals, or lamellar layers in aqueous solution. Suitable lipids for liposomal formulation include, without limitation, monoglycerides, diglycerides, sulfatides, lysolecithins, phospholipids, saponin, bile acids, and the like. Preparation of such liposomal formulations is within the level of skill in the art, as disclosed, for example, in U.S. Pat. Nos. 4,235,871; 4,501,728; 4,837,028; and 4,737,323, all of which are hereby incorporated herein by reference.
The amount of protein or other active ingredient of the present invention in the pharmaceutical composition of the present invention will depend upon the nature and severity of the condition being treated, and on the nature of prior treatments which the patient has undergone. Ultimately, the attending physician will decide the amount of protein or other active ingredient of the present invention with which to treat each individual patient. Initially, the attending physician will administer low doses of protein or other active ingredient of the present invention and observe the patient's response. Larger doses of protein or other active ingredient of the present invention may be administered until the optimal therapeutic effect is obtained for the patient, and at that point the dosage is not increased further. It is contemplated that the various pharmaceutical compositions used to practice the method of the present invention should contain about 0.01 μg to about 100 mg (preferably about 0.1 μg to about 10 mg, more preferably about 0.1 μg to about 1 mg) of protein or other active ingredient of the present invention per kg body weight. When administered, the therapeutic composition for use in this invention is, of course, in a pyrogen-free, physiologically acceptable form. Further, the composition may desirably be encapsulated or injected in a viscous form for delivery to the site of bone, cartilage or tissue damage. Therapeutically useful agents other than a protein or other active ingredient of the invention which may also optionally be included in the composition as described above, may alternatively or additionally, be administered simultaneously or sequentially with the composition in the methods of the invention.
The therapeutic compositions are also presently valuable for veterinary applications. Particularly domestic animals and thoroughbred horses, in addition to humans, are desired patients for such treatment with proteins or other active ingredient of the present invention. The dosage regimen of a protein-containing pharmaceutical composition to be used will be determined by the attending physician considering various factors which modify the action of the proteins, e.g., the patient's age, sex, and diet, the severity of any infection, time of administration and other clinical factors. The dosage may vary with the type protein used in co-administration. For example, the addition of other known protein factors, cytokines or the like to the final composition, may also affect the dosage. Progress can be monitored by periodic assessment of symptoms (for example high blood pressure).
Polynucleotides of the present invention can also be used for gene therapy. Such polynucleotides can be introduced either in vivo or ex vivo into cells for expression in a mammalian subject. Polynucleotides of the invention may also be administered by other known methods for introduction of nucleic acid into a cell or organism (including, without limitation, in the form of viral vectors or naked DNA). Cells may also be cultured ex vivo in the presence of proteins of the present invention in order to proliferate or to produce a desired effect on or activity in such cells. Treated cells can then be introduced in vivo for therapeutic purposes.
5.16.3 Effective Dosage
Pharmaceutical compositions suitable for use in the present invention include compositions wherein the active ingredients are contained in an effective amount to achieve its intended purpose. More specifically, a therapeutically effective amount means an amount effective to prevent development of or to alleviate the existing symptoms of the subject being treated (for example, high blood pressure). Determination of the effective amount is well within the capability of those skilled in the art, especially in light of the detailed disclosure provided herein. For any compound used in the method of the invention, the therapeutically effective dose can be estimated initially from appropriate in vitro assays. For example, a dose can be formulated in animal models to achieve a circulating concentration range that can be used to more accurately determine useful doses in humans. For example, a dose can be formulated in animal models to achieve a circulating concentration range that includes the IC50 as determined in cell culture (i.e., the concentration of the test compound which achieves a half-maximal inhibition of the protein's biological activity). Such information can be used to more accurately determine useful doses in humans.
A therapeutically effective dose refers to that amount of the compound that results in amelioration of symptoms or a prolongation of survival in a patient. Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD50 (the dose lethal to 50% of the population) and the ED50 (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio between LD50 and ED50. Compounds which exhibit high therapeutic indices are preferred. The data obtained from these cell culture assays and animal studies can be used in formulating a range of dosage for use in human. The dosage of such compounds lies preferably within a range of circulating concentrations that include the ED50 with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. The exact formulation, route of administration and dosage can be chosen by the individual physician in view of the patient's condition. See, e.g., Fingl et al., 1975, in “The Pharmacological Basis of Therapeutics”, Ch. 1 p.1. Dosage amount and interval may be adjusted individually to provide plasma levels of the active moiety which are sufficient to maintain the desired effects, or minimal effective concentration (MEC). The MEC will vary for each compound but can be estimated from in vitro data. Dosages necessary to achieve the MEC will depend on individual characteristics and route of administration. However, HPLC assays or bioassays can be used to determine plasma concentrations.
Dosage intervals can also be determined using MEC value. Compounds should be administered using a regimen that maintains plasma levels above the MEC for 10-90% of the time, preferably between 30-90% and most preferably between 50-90%. In cases of local administration or selective uptake, the effective local concentration of the drug may not be related to plasma concentration.
An exemplary dosage regimen for polypeptides or other compositions of the invention will be in the range of about 0.01 μg/kg to 100 mg/kg of body weight daily, with the preferred dose being about 0.1 μg/kg to 25 mg/kg of patient body weight daily, varying in adults and children. Dosing may be once daily, or equivalent doses may be delivered at longer or shorter intervals.
The amount of composition administered will, of course, be dependent on the subject being treated, on the subject's age and weight, the severity of the affliction, the manner of administration and the judgment of the prescribing physician.
5.16.4 Packaging
The compositions may, if desired, be presented in a pack or dispenser device which may contain one or more unit dosage forms containing the active ingredient. The pack may, for example, comprise metal or plastic foil, such as a blister pack. The pack or dispenser device may be accompanied by instructions for administration. Compositions comprising a compound of the invention formulated in a compatible pharmaceutical carrier may also be prepared, placed in an appropriate container, and labeled for treatment of an indicated condition.
5.17 Examples
The present invention is illustrated in the following examples. Upon consideration of the present disclosure, one of skill in the art will appreciate that many other embodiments and variations may be made in the scope of the present invention. Accordingly, it is intended that the broader aspects of the present invention not be limited to the disclosure of the following examples. The present invention is not to be limited in scope by the exemplified embodiments which are intended as illustrations of single aspects of the invention, and compositions and methods which are functionally equivalent are within the scope of the invention. Indeed, numerous modifications and variations in the practice of the invention are expected to occur to those skilled in the art upon consideration of the present preferred embodiments. Consequently, the only limitations which should be placed upon the scope of the invention are those which appear in the appended claims.
All references cited within the body of the instant specification are hereby incorporated by reference in their entirety.
EXAMPLES
Example 1
Isolation of SEQ ID NO: 1 through 852 from a cDNA Libraries of Human Cells
The novel nucleic acids of SEQ ID NO: 1 through 852 were obtained from several human normal and pre-eclamptic placental cDNA libraries using standard PCR, sequencing by hybridization sequence signature analysis, and Sanger sequencing techniques. The inserts of the library were amplified with PCR using primers specific for vector sequences flanking the inserts. These samples were spotted onto nylon membranes and interrogated with oligonucleotide probes to give sequence signatures. The clones were clustered into groups of similar or identical sequences, and single representative clones were selected from each group for gel sequencing. The 5′ sequence of the amplified inserts were then deduced using the reverse M13 sequencing primer in a typical Sanger sequencing protocol. PCR products were purified and subjected to fluorescent dye terminator cycle sequencing. Single-pass gel sequencing was done using a 377 Applied Biosystems (ABI) sequencer. These inserts was identified as a novel sequence not previously obtained from this library and not previously reported in public databases. These sequences are designated as SEQ ID NO: 1 through 852 in the attached sequence listing.
Example 2
Assemblage OF SEQ ID NO: 1 Through 852
The nucleic acids (SEQ ID NO: 1 through 852) of the invention were assembled from sequences that were obtained from various cDNA libraries by methods described in Example 1 above, and in some cases obtained from one or more public databases. The final sequence was assembled using the EST sequence as seed. Then a recursive algorithm was used to extend the seed into an extended assemblage, by pulling additional sequences from different databases (i.e. Nuvelo's database containing EST sequences, dbEST, gb pri, and UniGene) that belong to this assemblage. The algorithm terminated when there was no additional sequences from the above databases that would extend the assemblage. Inclusion of component sequences into the assemblage was based on a BLASTN hit to the extending assemblage with BLAST score greater than 300 and percent identity greater than 95%.
The nearest neighbor results for the assembled contigs (SEQ ID NO: 1-852) were obtained by using the BLASTN algorithm against the nucleotide (nt) database from Genbank (National Center for Biotechnology Information http://www.ncbi.nlm.nih.gov). The nucleotide database used was the version as of Dec. 30, 2002. The nearest neighbor results for the polypeptides (SEQ ID NO: 853-1704) corresponding to the assembled contigswere obtained by a FASTA search against Genpept, using FASTXY algorithm. FASTXY is an improved version of FASTA alignment that allows in-codon frame shifts. The version of the Genpept database was the version as of Jan. 10, 2003. The nearest neighbor results showed the closest homologue for each assemblage from Genpept (and contain the translated amino acid sequences for which the assemblages encodes SEQ ID NO 853 through 1704). The predicted amino acid sequences corresponding to SEQ ID NO: 1 through 852 were obtained by using a software program called FASTY (available from http://fasta:bioch.virginia.edu) which selects a polypeptide based on a comparison of translated novel polynucleotide to known polynucleotides (W. R. Pearson, Methods in Enzymology, 183:63-98 (1990), incorporated herein by reference). For ease of creating SEQ ID Numbers, the following formula was used: nucleotide SEQ ID NO added to 852. (For Example, the polypeptide corresponding to nucleotide SEQ ID NO 1 is SEQ ID NO 853).
The nearest neighbor results for both the nucleotide contigs (SEQ ID NO 1 through 852) and corresponding polypeptides (SEQ ID NO 853 through 1704) are set forth below. In some cases, no nearest neighbor result could be determined, and therefore are excluded from the following table.
TABLE 1
|
|
SEQGenbank
IDAccesssionBLASTPercent
NO:NumberScoreIdentityAnnotationOrganism
|
|
1AF090949171097HBV-X associated protein 2Cercopithecus
aethiops
1U31913173699HBV-X associated proteinHomo sapiens
1U785211740100immunophilin homolog ARA9Homo sapiens
2AAH123331168100BC012333 Unknown (protein forHomo sapiens
MGC: 2084)
2AF187981_11168100AF187981 delta7-sterol-C5-Homo sapiens
desaturase
2D851811273100fungal sterol-C5-desaturaseHomo sapiens
homolog
4A84511101799unnamed protein productunidentified
4AF498970_11016100AF498970 small GTP bindingHomo sapiens
protein RhoA
4AX427410101799unnamed protein productunidentified
5AAH0431248598BC004312 insulin-like growthHomo sapiens
factor binding protein 2 (36 kD)
5AAH0990248598BC009902 Unknown (protein forHomo sapiens
MGC: 2339)
5AAH1276948598BC012769 Unknown (protein forHomo sapiens
MGC: 16256)
6AAH02434430100BC002434 p8 protein (candidate ofHomo sapiens
metastasis 1)
6AF069074430100P8 proteinHomo sapiens
6AF135266_1430100AF135266 p8 protein homologHomo sapiens
7AB04789225882hypothetical proteinMacaca
fascicularis
8AAH0119983399BC001199 Similar to glucoseHomo sapiens
regulated protein, 58 kDa
8AJ44072183399thioredoxin related proteinHomo sapiens
8AL83442383399hypothetical proteinHomo sapiens
9AAH008661124100BC000866 tissue inhibitor ofHomo sapiens
metalloproteinase 1 (erythroid
potentiating activity,
collagenase inhibitor)
9M599061124100collagenase inhibitorHomo sapiens
9X031241124100precursorHomo sapiens
10AAH0051883483BC000518 Similar to brain acid-Homo sapiens
soluble protein 1
10AF03965682281neuronal tissue-enriched acidicHomo sapiens
protein
10AF521668_151659AF521668 CAP23Gallus
gallus
11AAH05931733100BC005931 hemoglobin, alpha 2Homo sapiens
11AAH08572733100BC008572 hemoglobin, alpha 2Homo sapiens
11BC032122733100hemoglobin, alpha 2Homo sapiens
12AF347006117190cytochrome c oxidase subunit IHomo sapiens
12AF382012115991cytochrome c oxidase subunit IHomo sapiens
12AF382013115991cytochrome c oxidase subunit IHomo sapiens
13AF242729_11242100AF242729 HT022Homo sapiens
13AJ2458741242100putative ATG/GTP binding proteinHomo sapiens
13AJ2503441242100hypothetical proteinHomo sapiens
14AAH170501367100BC017050 2,3-bisphosphoglycerateHomo sapiens
mutase
14M2306813671002,3-bisphosphoglycerateHomo sapiens
14X0432713671002,3 biphosphoglycerated mutaseHomo sapiens
(AA 1-259)
15AAH02334921100BC002334 DAZ associated protein 2Homo sapiens
15AAH07900921100BC007900 DAZ associated protein 2Homo sapiens
15D31767921100KIAA0058Homo sapiens
16AAH0957130898BC009571 Similar to stimulated byHomo sapiens
retinoic acid 13
16U9500630998D9 splice variant AHomo sapiens
16U9500727398D9 splice variant BHomo sapiens
17AAH1167449366BC011674 Similar to procollagen-Homo sapiens
lysine, 2-oxoglutarate 5-
dioxygenase 3
17AC004876_449366AC004876 lysyl hydroxylase 3Homo sapiens
17AF20706949366lysyl hydroxylase 3Homo sapiens
18AAH16765177899BC016765 Unknown (protein forHomo sapiens
MGC: 22663)
18AF153882_11785100AF153882 reversion-induced LIMHomo sapiens
protein
18AF154335_11785100AF154335 reversion-induced LIMHomo sapiens
protein
19AF023268115074metaxinHomo sapiens
19BC023071105068metaxinMus musculus
19U46920115074metaxinHomo sapiens
20AF03381536334Pr180Mason-Pfizer
monkey virus
20AF193053_1575100AF193053 unknownHomo sapiens
20Y1039250043proteaseHuman
endogenous
retrovirus K
21AF318351_13211100AF318351 unknownHomo sapiens
21AF318377_13211100AF318377 unknownHomo sapiens
21AX1067093211100unnamed protein productHomo sapiens
22AL3573742678100bA353C18.3.2 (splicing factorHomo sapiens
CC1.3, isoform 2 (CC1.4))
22AY061882266399transcription coactivator CAPERMus musculus
22L109112678100splicing factorHomo sapiens
23AAH08807206990BC008807 keratin 6AHomo sapiens
23AAH14152206990BC014152 Similar to keratin 6AHomo sapiens
23L42583206990keratin type IIHomo sapiens
24AK00049630172unnamed protein productHomo sapiens
24AK02511627167unnamed protein productHomo sapiens
24AK09051128260unnamed protein productHomo sapiens
25AAH16842243199BC016842 Unknown (protein forHomo sapiens
MGC: 10135)
25AK0276432435100unnamed protein productHomo sapiens
25AL834398252999hypothetical proteinHomo sapiens
26AAH025631176100BC002563 Similar to zinc/ironHomo sapiens
regulated transporter-like
26AAH078861176100BC007886 Unknown (protein forHomo sapiens
MGC: 14180)
26AAH143031176100BC014303 Unknown (protein forHomo sapiens
MGC: 16418)
27AF0567323342100prostaglandin transporterHomo sapiens
27BC041140345399solute carrier family 21Homo sapiens
(prostaglandin transporter),
member 2
27U708673342100prostaglandin transporter hPGTHomo sapiens
28AAH15206335100BC015206 guanine nucleotideHomo sapiens
binding protein 10
28AAH16319335100BC016319 guanine nucleotideHomo sapiens
binding protein 10
28AF493877_1335100AF493877 guanine nucleotideHomo sapiens
binding protein gamma 10
29D26307114866Jun-DRattus
norvegicus
29X51346141997jun-D gene product (AA 1-303)Homo sapiens
29X56681138896junD proteinHomo sapiens
30AY081680693100chlorophyll a/b-binding proteinArabidopsis
CP29thaliana
30AY133566693100At5g01530/F7A7_50Arabidopsis
thaliana
30BT000363693100chlorophyll a/b-binding proteinArabidopsis
CP29thaliana
31AY086905622100photosystem II type IArabidopsis
chlorophyll a/b binding protein,thaliana
putative
31AY128345622100photosystem II type I chlorophyllArabidopsis
a/b binding protein, putativethaliana
31BT000726622100putative photosystem II type IArabidopsis
chlorophyll a/b binding proteinthaliana
32AF177203_184798AF177203 cerebral cell adhesionHomo sapiens
molecule
32AK074519872100unnamed protein productHomo sapiens
32AK074523872100unnamed protein productHomo sapiens
33AY050935497100putative photosystem II type IArabidopsis
chlorophyll a/b binding proteinthaliana
33AY058180497100At1g29930/F1N18_23Arabidopsis
thaliana
33AY091169497100putative chlorophyll a/b-bindingArabidopsis
proteinthaliana
34AF178954214988monocarboxylate transporter 4Mus musculus
34U818002399100monocarboxylate transporterHomo sapiens
34U87627216488putative monocarboxylateRattus
transporternorvegicus
35AAH18345173100BC018345 Unknown (protein forHomo sapiens
MGC: 8802)
35AF237776_1173100AF237776 MAP kinase-interactingHomo sapiens
kinase 2b
35AL137565173100hypothetical proteinHomo sapiens
36AF006013377399dishevelled 3Homo sapiens
36BC032459378499dishevelled, dsh homolog 3Homo sapiens
(Drosophila)
36U756513806100dishevelled 3Homo sapiens
37AK0002682659100unnamed protein productHomo sapiens
37AK053678159871unnamed protein productMus musculus
37L00193134258epidermal keratin subunit IMus musculus
38AX354357840100unnamed protein productHomo sapiens
38BC00219824342Similar to hypothetical proteinMus musculus
FLJ20093
38BC03964265875Unknown (protein forMus musculus
IMAGE: 5352548)
39AF01234885784smooth muscle gamma actinGallus
gallus
39S6349485784gamma-actinGallus
gallus
39U2036585784smooth muscle gamma-actinMus musculus
40AB023209210261KIAA0992 proteinHomo sapiens
40AF077041_12057100AF077041 SIH002Homo sapiens
40AF151909_12161100AF151909 CGI-151 proteinHomo sapiens
41AF287271_1714100AF287271 ribosomal protein L23Mus musculus
41AF401577_1714100AF401577 ribosomal protein L23Ictalurus
punctatus
41BC025918714100ribosomal protein L23Mus musculus
42U43916817100TMPHomo sapiens
42Y07909817100progression associated proteinHomo sapiens
42Z50751817100B4BHomo sapiens
43AAH09647277899BC009647 Unknown (protein forHomo sapiens
MGC: 5096)
43M13078277399alkaline phosphatase precursorHomo sapiens
43M191592780100placental alkaline phosphatase-1Homo sapiens
44AF3265912240100fenestrated-endothelial linkedHomo sapiens
structure protein
44AF348827223299PV1 proteinHomo sapiens
44AL834363230499hypothetical proteinHomo sapiens
45AAH116865877100BC011686 damage-specific DNAHomo sapiens
binding protein 1 (127 kD)
45L403265877100X-associated protein 1Homo sapiens
45U182995877100DDBa p127Homo sapiens
46U666611330100GABA-A receptor epsilon subunitHomo sapiens
46Y076371330100putative GABA-gated chlorideHomo sapiens
channel
46Y097651330100GABA receptor epsilon subunitHomo sapiens
47AF380181_11150699AF380181 SON DNA binding proteinHomo sapiens
isoform C
47AF380184_11211799AF380184 SON DNA binding proteinHomo sapiens
isoform F
47AY0268951184297NREBPHomo sapiens
48A20470214299preA-PAI-2synthetic
construct
48AAH126092148100BC012609 Similar to serine (orHomo sapiens
cysteine) proteinase inhibitor,
clade B (ovalbumin), member 2
48Y00630213999PAI-2 precursor (AA −22 to 393)Homo sapiens
49AB0378197936100KIAA1398 proteinHomo sapiens
49AL132765578595bA462D18.3.2 (ribosome bindingHomo sapiens
protein 1 (dog 180 kDa homolog)
(KIAA1398) (isoform 2))
49X87224651884ribosome receptorCanis
familiaris
50AAH00716170099BC000716 seryl-tRNA synthetaseHomo sapiens
50D49914170099Seryl tRNA SynthetaseHomo sapiens
50X91257170099seryl-tRNA synthetaseHomo sapiens
51D29640469857KIAA0051Homo sapiens
51L33075469857ras GTPase-activating-likeHomo sapiens
protein
51U519038003100RasGAP-related proteinHomo sapiens
52AAH17338257699BC017338 fucosidase, alpha-L-1,Homo sapiens
tissue
52M298772581100alpha-L-fucosidase precursor (ECHomo sapiens
3.2.1.5)
52M80815257699alpha-L-fucosidaseHomo sapiens
53AAH030673601100BC003067 growth arrest and DNA-Homo sapiens
damage-inducible 34
53AK001361356899unnamed protein productHomo sapiens
53U839813601100apoptosis associated proteinHomo sapiens
54AAH0271737977BC002717 Similar to chorionicHomo sapiens
somatomammotropin hormone 1
(placental lactogen)
54AAH0592137977BC005921 chorionicHomo sapiens
somatomammotropin hormone 1
(placental lactogen)
54AAH2075637977BC020756 chorionicHomo sapiens
somatomammotropin hormone 1
(placental lactogen)
55M579392349100ribonucleoprotein antigenHomo sapiens
55X0465423859770 K protein (AA 1-614)Homo sapiens
55X84841234910068 kDa (U1) ribonucleoproteinHomo sapiens
56AAH09945373799BC009945 Unknown (protein forHomo sapiens
IMAGE: 4123572)
56AB0182895502100KIAA0746 proteinHomo sapiens
56AK030487462087unnamed protein productMus musculus
57AJ422147664100C15 proteinHomo sapiens
57AX352692664100unnamed protein productHomo sapiens
57AX357061664100unnamed protein productHomo sapiens
59AAH015011520100BC001501 Unknown (protein forHomo sapiens
MGC: 2233)
59AAH140781520100BC014078 cyclin D1 (PRAD1:Homo sapiens
parathyroid adenomatosis 1)
59BC0253021520100cyclin D1 (PRAD1: parathyroidHomo sapiens
adenomatosis 1)
60BC0362851936100protein kinase, cAMP-dependent,Homo sapiens
regulatory, type I, alpha (tissue
specific extinguisher 1)
60M184681936100cAMP-dependent protein kinaseHomo sapiens
regulatory subunit type 1
60M333361936100cAMP-dependent protein kinaseHomo sapiens
type I-alpha subunit
61BC024165600100polymerase (RNA) II (DNAHomo sapiens
directed) polypeptide J (13.3 kD)
61X82385600100RNA polymerase II subunitHomo sapiens
61X98433600100RNA polymerase II subunitHomo sapiens
62AL138761803399bA16H23.2 (collagen, type XVII,Homo sapiens
alpha 1 (BP180))
62M916698228100autoantigenHomo sapiens
62U76604803799180 kDa bullous pemphigoidHomo sapiens
antigen 2/type XVII collagen
63AAH035752373100BC003575 mannosyl (alpha-1,3-)-Homo sapiens
glycoprotein beta-1,2-N-
acetylglucosaminyltransferase
63M55621236399N-acetylglucosaminyltransferase IHomo sapiens
63M618292373100alpha-1,3-mannosyl-glycoproteinHomo sapiens
beta-1,2-N-
acetylglucosaminyltransferase
64L139231663999fibrillinHomo sapiens
64L287481636297putativeBos taurus
64X6355617359100fibrillinHomo sapiens
65AAH025763661100BC002576 matrix metalloproteinaseHomo sapiens
2 (gelatinase A, 72 kD gelatinase,
72 kD type IV collagenase)
65J032103584100collagenase type IV precursorHomo sapiens
65M555933661100type IV collagenaseHomo sapiens
66AAH22087246699BC022087 Similar to CD36 antigenHomo sapiens
(collagen type I receptor,
thrombospondin receptor)-like 1
66AF467889_1238086AF467889 high density lipoproteinSus scrofa
receptor SR-BI
66Z225552684100CLA-1Homo sapiens
67AF106202_11249100AF106202 endothelial cell proteinHomo sapiens
C receptor precursor
67AF375468_11249100AF375468 endothelial protein CHomo sapiens
receptor
67X890791249100centrocyclinHomo sapiens
68AF153603_1666100AF153603 TSC-22 related proteinHomo sapiens
68AF183393_1666100AF183393 TSC-22-like ProteinHomo sapiens
68AF228339666100glucocorticoid-induced GILZHomo sapiens
69AF111168358699unknownHomo sapiens
69AK075445287699unnamed protein productHomo sapiens
69AX136231287699unnamed protein productHomo sapiens
70AAH112341220100BC011234 Similar to splicingHomo sapiens
factor 30, survival of motor
neuron-related
70AF083385122010030 kDa splicing factor; SPF 30Homo sapiens
70AF1074631220100splicing factorHomo sapiens
71AAH102401921100BC010240 cathepsin BHomo sapiens
71L16510191299cathepsin BHomo sapiens
71M14221191599preprocathepsin BHomo sapiens
72AK05603339883unnamed protein productHomo sapiens
73AE014836_2118223AE014836 hypothetical proteinPlasnodium
falciparun
3D7
73AK03335417424unnamed protein productMus musculus
74AF222743_12415100AF222743 Sec61 alpha-1Mus musculus
74BC0037072415100sec61 homologMus musculus
74M966302415100sec61-like proteinRattus sp.
75AF332086_1319396AF332086 Rad21Mus musculus
75D385513284100The ha1237 gene product isHomo sapiens
related to S.pombe rad21 gene
product.
75X98294327599HR21spAHomo sapiens
76AAH16325925100BC016325 ADP-ribosylation factor 4Homo sapiens
76AF493883_1925100AF493883 ADP-ribosylation factorHomo sapiens
protein 4
76BC022866925100ADP-ribosylation factor 4Homo sapiens
77AAH18201763100BC018201 Unknown (protein forHomo sapiens
MGC: 21505)
77AF217965_1763100AF217965 unknownHomo sapiens
77AF217972_1763100AF217972 unknownHomo sapiens
78AAH00211112797BC000211 eukaryotic translationHomo sapiens
elongation factor 1 beta 2
78AAH04931112797BC004931 eukaryotic translationHomo sapiens
elongation factor 1 beta 2
78X60489112797elongation factor-1-betaHomo sapiens
79D82984175893C/EBP alpha proteinBos taurus
79U34070185796CCAAT/enhancer binding proteinHomo sapiens
alpha
79Y115251927100CCAAT/enhancer binding proteinHomo sapiens
alpha
80AK02511634171unnamed protein productHomo sapiens
80AK09051135872unnamed protein productHomo sapiens
80AK09637334170unnamed protein productHomo sapiens
81AAH139632458100BC013963 Similar to adenylylHomo sapiens
cyclase-associated protein
81AAH171962458100BC017196 adenylyl cyclase-Homo sapiens
associated protein
81M984742458100CAP proteinHomo sapiens
82AAH02464217599BC002464 coagulation factor IIHomo sapiens
(thrombin) receptor
82AF391809_1217999AF391809 coagulation factor IIHomo sapiens
(thrombin) receptor
82M624242187100thrombin receptorHomo sapiens
83AF085250759100calmodulinPerca
flavescens
83D83350759100calmodulinAnas
platyrhynchos
83K01945759100calmodulin (cDNA clone 71)Xenopus
laevis
84AL0502652193100hypothetical proteinHomo sapiens
84BC033475212896similar to TAR DNA-bindingMus musculus
protein-43 (TDP-43)
84U237312193100TAR DNA-binding protein-43Homo sapiens
85AAH01495167399BC001495 chromosome 1 openHomo sapiens
reading frame 8
85AAH163741697100BC016374 chromosome 1 openHomo sapiens
reading frame 8
85AF290615_1167399AF290615 liver membrane-boundHomo sapiens
protein
86AK02504731969unnamed protein productHomo sapiens
86AK09051132770unnamed protein productHomo sapiens
86AK09245035869unnamed protein productHomo sapiens
87AAH0064268399BC000642 MY047 proteinHomo sapiens
87AF063605688100brain my047 proteinHomo sapiens
87AX13611968399unnamed protein productHomo sapiens
88AF035947_11394100AF035947 cytokine-inducibleHomo sapiens
inhibitor of signalling type 1b
88AF132297_1133299AF132297 cytokine-inducible SH2-Homo sapiens
containing protein
88BC0315901321100cytokine inducible SH2-containingHomo sapiens
protein
89AF151018_1863100AF151018 HSPC184Homo sapiens
89AK012047863100unnamed protein productMus musculus
89AK075227863100unnamed protein productHomo sapiens
90AK02511632368unnamed protein productHomo sapiens
90AK09092931670unnamed protein productHomo sapiens
90U2237620361alternatively spliced productHomo sapiens
using exon 13A
91AAH0935778298BC009357 transgelin 2Homo sapiens
91AY00712788798similar to Homo sapiens mRNA for
KIAA0120 gene with GenBank
Accession Number D21261.1
91D2126178298similar to human 22 kDa, SM22 mRNAHomo sapiens
(HUM22SM).
92AE00596341391TonB-dependent receptorCaulobacter
crescentus
CB15
92AE00597830767TonB-dependent receptorCaulobacter
crescentus
CB15
92AE00597930767TonB-dependent receptorCaulobacter
crescentus
CB15
93AAH1400636781BC014006 Similar to 6-Homo sapiens
phosphogluconolactonase
93AJ243972367816-phosphogluconolactonaseHomo sapiens
93BC00659432571RIKEN cDNA 1110030K05 geneMus musculus
94AAH03125205599BC003125 Unknown (protein forHomo sapiens
MGC: 3222)
94AK027877205599unnamed protein productHomo sapiens
94AL136916205599hypothetical proteinHomo sapiens
95AAH036812956100BC003681 Unknown (protein forHomo sapiens
IMAGE: 3453235)
95AL0968283008100dJ963E22.1 (Novel protein similarHomo sapiens
to NY-REN-2 Antigen)
95AX400070287896unnamed protein productHomo sapiens
96AF161372_1872100AF161372 HSPC254Homo sapiens
96BC02160251998Unknown (protein forMus musculus
IMAGE: 5102170)
96BC02160351998Unknown (protein forMus musculus
IMAGE: 5102465)
97AAH11714476100BC011714 Similar to heterogeneousHomo sapiens
nuclear ribonucleoprotein D-like
97AB017020476100JKTBPMus musculus
97BC021374476100heterogeneous nuclearMus musculus
ribonucleoprotein D-like
98AAH026731063100BC002673 protein kinase H11;Homo sapiens
small stress protein-like protein
HSP22
98AF191017_11063100AF191017 E2IG1Homo sapiens
98AF250138_11063100AF250138 small stress protein-Homo sapiens
like protein HSP22
99AAH05033299099BC005033 Unknown (protein forHomo sapiens
MGC: 12692)
99AAH15620299099BC015620 Unknown (protein forHomo sapiens
IMAGE: 4843317)
99D89980299099alpha actinin 4Homo sapiens
100AAH119081787100BC011908 Unknown (protein forHomo sapiens
MGC: 20321)
100AAH145641787100BC014564 Unknown (protein forHomo sapiens
MGC: 2063)
100AAH186951787100BC018695 Unknown (protein forHomo sapiens
MGC: 3838)
101AAH129771363100BC012977 nuclear LIM interactor-Homo sapiens
interacting factor
101AF229162_11363100AF229162 nuclear LIM interactor-Homo sapiens
interacting factor
101AF2291631363100nuclear LIM interactor-Homo sapiens
interacting factor
102AAH0971835576BC009718 epithelial membraneHomo sapiens
protein 3
102U5210135576YMPHomo sapiens
102U8794735576hematopoietic neural membraneHomo sapiens
protein
103AF162781_1498788AF162781 SH2-containing inositolMus musculus
5-phosphatase 2
103L3681860419951C proteinHomo sapiens
103Y14385527292inositol polyphosphate 5-Homo sapiens
phosphatase
104AAH17369101192BC017369 splicing factor,Homo sapiens
arginine/serine-rich 7 (35 kD)
104AAH17908101192BC017908 splicing factor,Homo sapiens
arginine/serine-rich 7 (35 kD)
104BC022328101192splicing factor, arginine/serine-Homo sapiens
rich 7 (35 kD)
105AAH14323120999BC014323 Similar to accessoryHomo sapiens
proteins BAP31/BAP29
105X811091213100tumor-associated antigenHomo sapiens
105Z316961213100CDMHomo sapiens
106AAH157633102100BC015763 hypothetical proteinHomo sapiens
FLJ20258
106AK000265309399unnamed protein productHomo sapiens
106AK075098299899unnamed protein productHomo sapiens
107AAH078582250100BC007858 inhibin, beta A (activinHomo sapiens
A, activin AB alpha polypeptide)
107M134362250100beta-A inhibinHomo sapiens
107X575782250100activin beta-A subunitHomo sapiens
108AK0275983474100unnamed protein productHomo sapiens
108AX481758349899unnamed protein productHomo sapiens
108AX481760349899unnamed protein productHomo sapiens
109AAH15958192686BC015958 Unknown (protein forHomo sapiens
MGC: 15290)
109AJ401269192686polyadenylate-binding protein 1Bos taurus
109AK044829192285unnamed protein productMus musculus
110AAH10623372996BC010623 Similar to nuclearHomo sapiens
factor (erythroid-derived 2)-like 1
110AK0904594032100FLJ00380 proteinHomo sapiens
110X773663926100hbZ17Homo sapiens
111AAH031773500100BC003177 KIAA1536 proteinHomo sapiens
111AK027881348099unnamed protein productHomo sapiens
111AL1368953500100hypothetical proteinHomo sapiens
112AY054301498194type III preprocollagen alpha 1Homo sapiens
chain
112BC0281786603100Similar to collagen, type III,Homo sapiens
alpha 1 (Ehlers-Danlos syndrome
type IV, autosomal dominant)
112X14420498194prepro-alpha-1 type 3 collagenHomo sapiens
113AAH11819347399BC011819 DEAD/H (Asp-Glu-Ala-Homo sapiens
Asp/His) box polypeptide 3
113AF0009823476100dead box, X isoformHomo sapiens
113AF0009833476100dead box, X isoformHomo sapiens
114AAH149591160100BC014959 RING1 and YY1 bindingHomo sapiens
protein
114AF179286_11160100AF179286 death effector domain-Homo sapiens
associated factor
114BC036459115699RING1 and YY1 binding proteinHomo sapiens
115AK00279128281unnamed protein productMus musculus
115AK00329228281unnamed protein productMus musculus
115BC01619128281RIKEN cDNA 0610038D11 geneMus musculus
116AAH084421106100BC008442 Similar to transmembraneHomo sapiens
4 superfamily member 1
116AAH101661106100BC010166 Similar to transmembraneHomo sapiens
4 superfamily member 1
116M906571106100L6Homo sapiens
117AAH103541764100BC010354 PTD010 proteinHomo sapiens
117AB0096851764100DERP2Homo sapiens
117AF1318201764100UnknownHomo sapiens
118AF217787117299extracellular glutathioneHomo sapiens
peroxidase
118D00632119299glutathione peroxidaseHomo sapiens
118X58295119299glutathione peroxidaseHomo sapiens
119AAH0053193997BC000531 insulin-like growthHomo sapiens
factor 2 (somatomedin A)
119AF517226_193997AF517226 insulin-like growthHomo sapiens
factor 2 (somatomedin A)
119M1786394297preproinsulin-like growth factorHomo sapiens
II, domains A-E
120AJ3105442183100EGLN2 proteinHomo sapiens
120AX5538642183100unnamed protein productHomo sapiens
120BC0360512183100Similar to egl nine homolog 2 (C. elegans)Homo sapiens
121AAH0086791598BC000867 PRO0659 proteinHomo sapiens
121AL834135111899hypothetical proteinHomo sapiens
121AX405861111899unnamed protein productHomo sapiens
122AB051480108760KIAA1693 proteinHomo sapiens
122AL136890174183hypothetical proteinHomo sapiens
122AX402334108460unnamed protein productHomo sapiens
123AB037755489699KIAA1334 proteinHomo sapiens
123AF155135_1484599AF155135 novel retinal pigmentHomo sapiens
epithelial cell protein
123AF202315_1414185AF202315 ankycorbinMus musculus
124AK09092932976unnamed protein productHomo sapiens
124AK09796533877unnamed protein productHomo sapiens
124BC03395933670similar to Alu subfamily SQHomo sapiens
sequence contamination warning
entry
125AAH124441319100BC012444 Similar to chlorideHomo sapiens
intracellular channel 4
125AF097330_1130599AF097330 H1 chloride channel;Homo sapiens
p64H1; CLIC4
125AL1174241319100hypothetical proteinHomo sapiens
126AB034747904100small integral membrane proteinHomo sapiens
of lysosome/late endosome
126AF17110081285TBX1 proteinMus musculus
126BC01855981285LPS-induced TNF-alpha factorMus musculus
127AAH106451737100BC010645 Similar toHomo sapiens
sialyltransferase 4C (beta-
galactosidase alpha-2,3-
sialytransferase)
127AY040826171597alpha 2,3-sialyltransferase IVHomo sapiens
type B+18
127L237671710100a2,3 sialyltransferseHomo sapiens
128AAH0932963964BC009329 triosephosphateHomo sapiens
isomerase 1
128AAH1161163964BC011611 Similar toHomo sapiens
triosephosphate isomerase 1
128AAH1510063964BC015100 triosephosphateHomo sapiens
isomerase 1
129AAH18986106491BC018986 Unknown (protein forHomo sapiens
MGC: 20092)
129AB059653106090prostaglandin dehydrogenase IMacaca
fascicularis
129L76465105790NAD+-dependent 15-Homo sapiens
hydroxyprostaglandin
dehydrogenase
130AAH00690794100BC000690 ribosomal protein L24Homo sapiens
130BC002110794100ribosomal protein L24Mus musculus
130X78443794100ribosomal protein L24Rattus
norvegicus
131AAH114021122100BC011402 Similar to decidualHomo sapiens
protein induced by progesterone
131AB0227181122100DEPPHomo sapiens
131AL136653111699hypothetical proteinHomo sapiens
132AF10884140281pol proteinHomo sapiens
132AF10884341575pol proteinHomo sapiens
132U8890231773integraseHomo sapiens
133A07358140899VAC betaMus musculus
133AAH043761417100BC004376 annexin A8Homo sapiens
133X16662140899vascular anticoagulant-beta (AA 1-327)Homo sapiens
134AF0682272236100putative transmembrane proteinHomo sapiens
134AK032293142676unnamed protein productMus musculus
134BC025487144777Similar to ceroid-lipofuscinosis,Mus musculus
neuronal 5
135AAH106521355100BC010652 Unknown (protein forHomo sapiens
MGC: 9753)
135AF217980_1133898AF217980 unknownHomo sapiens
135AX11906396596unnamed protein productHomo sapiens
136AK00049637471unnamed protein productHomo sapiens
136AK02511640072unnamed protein productHomo sapiens
136AK05783036972unnamed protein productHomo sapiens
137AF0019001702100secreted frizzled-related proteinHomo sapiens
137AF0560871702100secreted frizzled related proteinHomo sapiens
137BC036503169099Unknown (protein for MGC: 43294)Homo sapiens
138AAH140522127100BC014052 transcriptional co-Homo sapiens
activator with PDZ-binding motif
(TAZ)
138AJ2994312127100transcriptional coactivatorHomo sapiens
138AK0220362127100unnamed protein productHomo sapiens
139AAH0749325480BC007493 galactosidase, beta 1Homo sapiens
139M2259025480beta-galactosidase precursor (ECHomo sapiens
3.2.1.23)
139M3442325480beta-galactosidase precursor (ECHomo sapiens
3.2.1.23)
140AAH159282186100BC015928 Unknown (protein forHomo sapiens
MGC: 8773)
140AB0377972313100KIAA1376 proteinHomo sapiens
140AK088288215398unnamed protein productMus musculus
141AF087873_1383100AF087873 protein kinase inhibitorHomo sapiens
141AF225513_1383100AF225513 cAMP-dependent proteinHomo sapiens
kinase inhibitor beta
141BC036011383100protein kinase (cAMP-dependent,Homo sapiens
catalytic) inhibitor beta
142X53305736100stathminHomo sapiens
142X94912736100Pr22Homo sapiens
142Z11566736100Pr22 proteinHomo sapiens
143AF148856_215079AF148856 unknownHomo sapiens
143AL09674415382hypothetical proteinHomo sapiens
143M8034115079ORF2Homo sapiens
144AF42137561944unknownHomo sapiens
144AK00215479894unnamed protein productHomo sapiens
144AK023417819100unnamed protein productHomo sapiens
145AF151807_1219799AF151807 CGI-49 proteinHomo sapiens
145AK075178215097unnamed protein productHomo sapiens
145BC026185213797Similar to CGI-49 proteinHomo sapiens
146AAH101232134100BC010123 SH3-domain bindingHomo sapiens
protein 5 (BTK-associated)
146AB0050472134100SH3 binding proteinHomo sapiens
146AB027562200894vascular endothelial cellRattus
specific protein 18norvegicus
147AJ131023530999oxytocinase/insulin-responsiveHomo sapiens
aminopeptidase, variant 1
147U62768531899oxytocinase splice variant 1Homo sapiens
147U62769524299oxytocinase splice variant 2Homo sapiens
148AF234263252199cathepsin CHomo sapiens
148U794152527100prepro dipeptidyl peptidase IHomo sapiens
148X872122527100cathepsin CHomo sapiens
149BC003426143894Similar to eukaryotic translationMus musculus
initiation factor 2B, subunit 1
(alpha, 26 kD)
149U05821141992translation initiation factorRattus
eIF-2B alpha-subunitnorvegicus
149X956481526100alfa subunitHomo sapiens
150AAH14093267897BC014093 Similar to amilorideHomo sapiens
binding protein 1 (amine oxidase
(copper-containing))
150M55602243189amiloride-binding proteinHomo sapiens
150X78212267897amiloride binding proteinHomo sapiens
151AK00363392598unnamed protein productMus musculus
151AK00798992598unnamed protein productMus musculus
151AK07621292598unnamed protein productMus musculus
152AAH18340169299BC018340 Unknown (protein forHomo sapiens
MGC: 9372)
152X79066169299ERF-1Homo sapiens
152X99404168499Berg36Homo sapiens
153AB05597749293I3 proteinHomo sapiens
153AF04143049293pRGR2Homo sapiens
153AF10696649293I3 proteinHomo sapiens
154AAH144381018100BC014438 Unknown (protein forHomo sapiens
MGC: 22947)
154AE006639_31018100AE006639 HN1 likeHomo sapiens
154AK0231541018100unnamed protein productHomo sapiens
155J037793944100common acute lymphoblasticHomo sapiens
leukemia antigen precursor
155M26628391999enkephalinaseHomo sapiens
155Y00811391999CALLA protein (AA 1-750)Homo sapiens
156AB0353044092100cadherin-5Homo sapiens
156U84722408699vascular endothelial cadherinHomo sapiens
156X799814092100VE-cadherinHomo sapiens
157AX019983739100unnamed protein productHomo sapiens
157BC026254739100insulin-like 4 (placenta)Homo sapiens
157L34838739100EPILHomo sapiens
158AF139894_11813100AF139894 RNA-binding proteinMus musculus
alpha-CP1
158AF139895_11813100AF139895 RNA-binding proteinMus musculus
alpha-CP1
158BC0047931813100poly(rC)-binding protein 1Mus musculus
159U1239036967beta-galactosidase alpha peptideCloning
vector
pSport1
159U1239135588beta-galactosidase alpha peptideCloning
vector
pSport2
159Y1483629468beta-galactosidasePhagemid
cloning
vector
pTZ19U
160AF218012_11751100AF218012 unknownHomo sapiens
160AF218030_11751100AF218030 unknownHomo sapiens
160AL1215861778100dJ477O4.1.1 (novel proteinHomo sapiens
similar to otoferlin and
dysferlin, isoform 1)
161AAH003521286100BC000352 proteasome (prosome,Homo sapiens
macropain) activator subunit 1
(PA28 alpha)
161AAH075031286100BC007503 proteasome (prosome,Homo sapiens
macropain) activator subunit 1
(PA28 alpha)
161AF078829_11286100AF078829 proteasome activatorHomo sapiens
PA28 alpha
162AAH16155382100BC016155 Ras homolog enriched inHomo sapiens
brain 2
162AF493921_1382100AF493921 Ras family small GTPHomo sapiens
binding protein RHEB2
162Z29677382100Ras-related GTP-binding proteinHomo sapiens
163AAH104232657100BC010423 Ig superfamily receptorHomo sapiens
LNIR
163AF160477_1265599AF160477 Ig superfamily receptorHomo sapiens
LNIR precursor
163AF426163_12657100AF426163 nectin 4Homo sapiens
164AJ295142357899Clq receptor proteinHomo sapiens
164BC028075357799complement component 1, qHomo sapiens
subcomponent, receptor 1
164U943333587100C1qR(p)Homo sapiens
165AAH142713392100BC014271 endoglin (Osler-Rendu-Homo sapiens
Weber syndrome 1)
165J05481331999endoglin precursorHomo sapiens
165U37439338599endoglinHomo sapiens
166AAH0741132398BC007411 Unknown (protein forHomo sapiens
MGC: 2554)
166AF05178231997diaphanous 1Homo sapiens
166U9696332298p140mDiaMus musculus
167AF151966_1187566AF151966 GTPase activatingGallus
protein Rap1-GAPgallus
167BC030891210995Unknown (protein forMus musculus
IMAGE: 4485689)
167M647883477100GTPase activating proteinHomo sapiens
168AX2067081968100unnamed protein productHomo sapiens
168M929341968100connective tissue growth factorHomo sapiens
168X789471968100connective tissue growth factorHomo sapiens
169AAH18823849100BC018823 Unknown (protein forHomo sapiens
MGC: 1236)
169AK00772980997unnamed protein productMus musculus
169U30826849100SRp40-1Homo sapiens
170AAH073332823100BC007333 etc variant gene 5 (ets-Homo sapiens
related molecule)
170X761842823100etc-related proteinHomo sapiens
170X963812823100ermHomo sapiens
171AAH0259999699BC002599 corticotropin releasingHomo sapiens
hormone
171AAH1103199699BC011031 Similar to corticotropinHomo sapiens
releasing hormone
171V0057199699corticotropin releasing factorHomo sapiens
172AF151872_11069100AF151872 CGI-114 proteinHomo sapiens
172AL110239106699hypothetical proteinHomo sapiens
172AX3998651069100unnamed protein productHomo sapiens
173AAH007321553100BC000732 glioblastoma amplifiedHomo sapiens
sequence
173AAH018371553100BC001837 glioblastoma amplifiedHomo sapiens
sequence
173BC0308211553100glioblastoma amplified sequenceHomo sapiens
174AAH014832103100BC001483 Unknown (protein forHomo sapiens
MGC: 1364)
174AAH092412103100BC009241 Unknown (protein forHomo sapiens
MGC: 3556)
174BC0235992103100TRK-fused geneHomo sapiens
175AAH128063278100BC012806 solute carrier family 5Homo sapiens
(sodium-dependent vitamin
transporter), member 6
175AAH156313278100BC015631 solute carrier family 5Homo sapiens
(sodium-dependent vitamin
transporter), member 6
175AF116241327299sodium-dependent multivitaminHomo sapiens
transporter
177AAH04324744100BC004324 ribosomal protein S16Homo sapiens
177AAH07977744100BC007977 ribosomal protein S16Homo sapiens
177X17665744100ribosomal protein S16 (AA 1-146)Rattus
rattus
178AB04755562490IZP6Mus musculus
musculus
178AK00794862490unnamed protein productMus musculus
178BC00472962490RIKEN cDNA 1810063P04 geneMus musculus
179BC0033371957100actin, gamma 1Mus musculus
179BC0217961957100actin, gamma 1Mus musculus
179BC0232481957100actin, gamma, cytoplasmicMus musculus
180AAH117002048100BC011700 glutamate-ammonia ligaseHomo sapiens
(glutamine synthase)
180AAH118522048100BC011852 glutamate-ammonia ligaseHomo sapiens
(glutamine synthase)
180AAH189922048100BC018992 Unknown (protein forHomo sapiens
MGC: 20095
181AF234654_11155100AF234654 PLAC1Homo sapiens
181AK0750861155100unnamed protein productHomo sapiens
181BC0223351155100placenta-specific 1Homo sapiens
182AAB67977410899AF019413 complement factor BHomo sapiens
182AAH041434121100BC004143 B-factor, properdinHomo sapiens
182AAH079904121100BC007990 B-factor, properdinHomo sapiens
183AAH1739935598BC017399 Similar to RIKEN cDNAHomo sapiens
1810037I17 gene
183AK00772123668unnamed protein productMus musculus
183BC00213523668Unknown (protein for MGC: 7243)Mus musculus
184AAH133831701100BC013383 calumeninHomo sapiens
184AF0137591701100calumeinHomo sapiens
184U67280169599calumeninHomo sapiens
185AF06906559697induced cAMP early repressorHomo sapiens
type 1
185AJ31166758895induced cAMP early repressor,Mus musculus
ICER I
185D14826608100hCREM 2alpha-a proteinHomo sapiens
186AAH004521043100BC000452 Similar to thioredoxinHomo sapiens
peroxidase 1
186AAH030221043100BC003022 Similar to thioredoxinHomo sapiens
peroxidase 1
186BC0394281043100Similar to peroxiredoxin 2Homo sapiens
187AB0561072995100zinc finger protein homologous toHomo sapiens
mouse Zfp91
187AB0574432775100testis specific ZFP91Homo sapiens
187AF310246_1258699AF310246 FKSG11Homo sapiens
188AF0234764954100meltrin-L precursorHomo sapiens
188AF023477385599meltrin-SHomo sapiens
188D50411393980meltrin alphaMus musculus
189AF154121_1219594AF154121 sodium-dependent high-Homo sapiens
affinity dicarboxylate
transporter
189AL034424212691dJ257E24.2.1 (sodium-dependentHomo sapiens
high-affinity dicarboxylate
transporter (NADC3, SDCT2)
(isoform 1))
189AY072810212691energy metabolism-related sodium-Homo sapiens
dependent high-affinity
dicarboxylate transporter
190AF40059435254endothelial nitric oxide synthaseHomo sapiens
190AF519768_135254AF519768 nitric oxide synthase 3Homo sapiens
(endothelial cell)
190D2660735053endothelial nitric oxide synthaseHomo sapiens
191AAH014621835100BC001462 protease, serine, 8Homo sapiens
(prostasin)
191L413511835100prostasinHomo sapiens
191U334461835100prostasinHomo sapiens
192AK02511627273unnamed protein productHomo sapiens
192AK09091331071unnamed protein productHomo sapiens
192BC03395920070similar to Alu subfamily SQHomo sapiens
sequence contamination warning
entry
193AF346465729191latent transforming growth factorMus musculus
beta binding protein 1S
193AF489528_1788799AF489528 transforming growthHomo sapiens
factor-beta binding protein-1S
193M340577903100transforming growth factor-beta 1Homo sapiens
binding protein precursor
194AY004254119990endoplasmic reticulum protein 29Rattus
precursornorvegicus
194X949101334100ERp28Homo sapiens
194Y10264119990ERp29 precursorRattus
norvegicus
195AF119917_58250100AF119896 PRO2751Homo sapiens
196AB0206924158100KIAA0885 proteinHomo sapiens
196BC016898410798Unknown (protein for MGC: 19174)Mus musculus
196X52311410298unr protein (AA 1-798)Rattus
norvegicus
198AL049698703498dJ470B24.1.3 (myeloid/lymphoid orHomo sapiens
mixed-lineage leukemia (trithorax
(Drosophila) homolog);
translocated to, 4 (AF-6)
(isoform 3))
198AL049698705098dJ470B24.1.5 (myeloid/lymphoid orHomo sapiens
mixed-lineage leukemia (trithorax
(Drosophila) homolog);
translocated to, 4 (AF-6)
(isoform 5))
198AL1619737363100hypothetical proteinHomo sapiens
199AAH212882134100BC021288 Unknown (protein forHomo sapiens
MGC: 29494)
199J03263193498membrane glycoproteinHomo sapiens
199J04182204196lysosomal membrane glycoprotein-1Homo sapiens
200AC002400817100Acyl carrier protein,Homo sapiens
Mitochondrial (ACP) (5′partial)
200AF087660_1788100AF087660 NADH: ubiquinoneHomo sapiens
oxidoreductase SDAP subunit
200AK01871767285unnamed protein productMus musculus
201AB031550129887pctp-LMus musculus
201AF151810_1147090AF151810 CGI-52 proteinHomo sapiens
201Z8113441939Hypothetical protein T28D6.7Caenorhabditis
elegans
203AAH09392530699BC009392 Unknown (protein forHomo sapiens
MGC: 15329)
203AB0111495318100KIAA0577 proteinHomo sapiens
203AP0005125318100RNA helicaseHomo sapiens
204AAH08751375799BC008751 calpain 1, (mu/I) largeHomo sapiens
subunit
204AAH172003762100BC017200 calpain 1, (mu/I) largeHomo sapiens
subunit
204X043663762100CANP, large subunit (aa 1-714)Homo sapiens
205AB093679740100ribosomal protein L26Macaca
fascicularis
205X69392740100ribosomal protein L26Homo sapiens
205X80699740100L26Mus musculus
206AAH063911974100BC006391 inhibin, alphaHomo sapiens
206M139811974100inhibin A-subunit precursorHomo sapiens
206X044451974100preproinhibinHomo sapiens
207AK02511619066unnamed protein productHomo sapiens
207AK09245030063unnamed protein productHomo sapiens
207AK09721430568unnamed protein productHomo sapiens
208AF130117_4833773AF130089 PRO2550Homo sapiens
208AK00038533370unnamed protein productHomo sapiens
208AK09245033670unnamed protein productHomo sapiens
209AB06248516177OK/SW-CL.18Homo sapiens
209AF090930_117251AF090930 PRO0478Homo sapiens
209AX39991915868unnamed protein productHomo sapiens
210AF063591_1140199AF063591 brain my033 proteinHomo sapiens
210BC0225221411100antigen identified by monoclonalHomo sapiens
antibody MRC OX-2
210BC0311031411100antigen identified by monoclonalHomo sapiens
antibody MRC OX-2
211AAH006922582100BC000692 Similar toHomo sapiens
hyaluronoglucosaminidase 2
211AC002455257999human PH-20 homolog (LUCA-2)Homo sapiens
211U09577257999lysosomal hyaluronidaseHomo sapiens
212AAH027002294100BC002700 Similar to keratin 7Homo sapiens
212AF5098872294100keratin 7Homo sapiens
212AF5098922294100keratin 7Homo sapiens
213AF523361_1195199AF523361 CD34 antigenHomo sapiens
213M819451955100hematopoietic stem cell antigenHomo sapiens
213S53910195199CD34Homo sapiens
214AB037891493100Bc10Mus musculus
214AF303656_1493100AF303656 bladder cancer-relatedMus musculus
protein
214BC026935493100bladder cancer associated proteinMus musculus
215AF3229093026100transmembrane glycoprotein HGFINHomo sapiens
215BC032783300397Similar to glycoproteinHomo sapiens
(transmembrane) nmb
215X765343026100NMBHomo sapiens
216AAH173523091100BC017352 Unknown (protein forHomo sapiens
MGC: 29525)
216AF230388_1308599AF230388 tripartite motif proteinHomo sapiens
TRIM29 alpha
216L24203308599ataxia-telangiectasia group D-Homo sapiens
associated protein
217AK003609523100unnamed protein productMus musculus
217AL136635523100hypothetical proteinHomo sapiens
217BC016408523100RIKEN cDNA 1110011F09 geneMus musculus
218AF0733107103100insulin receptor substrate-2Homo sapiens
218AF385932_1701499AF385932 insulin receptorHomo sapiens
substrate 2 insertion mutant
218AF385933_1702699AF385933 insulin receptorHomo sapiens
substrate 2 insertion mutant
219AAH09586158470BC009586 Unknown (protein forHomo sapiens
MGC: 14649)
219D26485158470core I proteinHomo sapiens
219L16842158470ubiquinol-cytochrome c reductaseHomo sapiens
core I protein
220AF0625341919100genethonin 1Homo sapiens
220AK050416108362unnamed protein productMus musculus
220BC0223011919100genethonin 1Homo sapiens
221AAH08950956100BC008950 Unknown (protein forHomo sapiens
MGC: 3593)
221AF112202_1956100AF112202 prenylated rab acceptor 1Homo sapiens
221AJ13353495199prenylated Rab acceptor 1 (PRA1)Homo sapiens
222AAH14257888100BC014257 Similar to DKFZp564J157Homo sapiens
protein
222AAH16064888100BC016064 DKFZp564J157 proteinHomo sapiens
222AX405840888100unnamed protein productHomo sapiens
223AAH023942275100BC002394 ceroid-lipofuscinosis,Homo sapiens
neuronal 3, juvenile (Batten,
Spielmeyer-Vogt disease)
223AAH044332275100BC004433 ceroid-lipofuscinosis,Homo sapiens
neuronal 3, juvenile (Batten,
Spielmeyer-Vogt disease)
223U326802275100CLN3 proteinHomo sapiens
224AF443072_11765699AF443072 laminin alpha5 chainHomo sapiens
precursor
224AL3548361766899bA157P1.1.1 (laminin alpha 5)Homo sapiens
224AX4637381765699laminin 5Homo sapiens
225BC024366703100ribosomal protein L27Mus musculus
225X07424703100ribosomal protein L27 (AA 1-136)Rattus
norvegicus
225X56852703100ribosomal protein L27Gallus
gallus
226AAH13131969100BC013131 Similar to hypotheticalHomo sapiens
protein FLJ10702
226AK001564969100unnamed protein productHomo sapiens
226BC013719969100hypothetical protein FLJ10702Mus musculus
227AF214737_15676100AF214737 C9orf10aHomo sapiens
227BC010304376593Unknown (protein forMus musculus
IMAGE: 3597827)
227D800055676100KIAA0183Homo sapiens
228AF113127_1118699AF113127 S1R proteinHomo sapiens
228AF151877_1120394AF151877 CGI-119 proteinHomo sapiens
228AF182041_1118699AF182041 z-proteinHomo sapiens
229AAH116161514100BC011616 Similar to cyclin D3Homo sapiens
229AF517525_1151199AF517525 cyclin D3Homo sapiens
229M922871514100cyclin D3Homo sapiens
230AAH115814280100BC011581 Similar to oxysterolHomo sapiens
binding protein
230AF185696_14280100AF185696 oxysterol-bindingHomo sapiens
protein 1
230AF1857054280100oxysterol binding protein 1Homo sapiens
231AF05374546232pol polyproteinMus dunni
endogenous
virus
231AF15179447335pol proteinPhascolarctos
cinereus
231D1003250636gag-pol precursor polyproteinBaboon
endogenous
virus strain
M7
232AF012920625100GEC-1Cavia
porcellus
232AF312680625100GEC-1Cavia
porcellus
232BC004602625100RIKEN cDNA 9130422N19 geneMus musculus
233AAH142411733100BC014241 Similar to hypotheticalHomo sapiens
protein, MGC: 7035
233AB093636168796hypothetical proteinMacaca
fascicularis
233AK046512127474unnamed protein productMus musculus
234AF140240_1749100AF140240 transcription factorHomo sapiens
TBX3
234AK075457749100unnamed protein productHomo sapiens
234BC025258749100T-box 3 (ulnar mammary syndrome)Homo sapiens
235AB06247716664OK/SW-CL.41Homo sapiens
235AK05484016765unnamed protein productHomo sapiens
235AK09288822474unnamed protein productHomo sapiens
236AAH01863320100BC001863 hypoxia-inducibleHomo sapiens
protein 2
236AF144755_1320100AF144755 hypoxia-inducibleHomo sapiens
protein 2
236AX105363320100unnamed protein productHomo sapiens
237AAH00718102597BC000718 Similar to dynamitinHomo sapiens
(dynactin complex 50 kD subunit)
237AAH09468102597BC009468 dynactin 2 (p50)Homo sapiens
237AAH14083102597BC014083 dynactin 2 (p50)Homo sapiens
238AB0376692790100L-type amino acid transporter 2Homo sapiens
238AF171669_12790100AF171669 glycoprotein-associatedHomo sapiens
amino acid transporter LAT2
238Y18483277899SLC7A8 proteinHomo sapiens
239AF118094_2118748AF118082 PRO1902Homo sapiens
239AF119917_1315861AF119851 PRO1722Homo sapiens
239AK09726618560unnamed protein productHomo sapiens
240AK075392135390unnamed protein productHomo sapiens
240AX136157135390unnamed protein productHomo sapiens
240AX17929313569021676 ADHHomo sapiens
241AF328769_1242691AF328769 PC2-glutamine-rich-Homo sapiens
associated protein
241AK090465267799FLJ00386 proteinHomo sapiens
241BC017110267799Unknown (protein for MGC: 16010)Homo sapiens
242AAH105142363100BC010514 clusterin (complementHomo sapiens
lysis inhibitor, SP-40,40,
sulfated glycoprotein 2,
testosterone-repressed prostate
message 2, apolipoprotein J)
242AAH195882363100BC019588 clusterin (complementHomo sapiens
lysis inhibitor, SP-40,40,
sulfated glycoprotein 2,
testosterone-repressed prostate
message 2, apolipoprotein J)
242X147232363100SP-40,40 prepropetide (AA −22 toHomo sapiens
427)
243AAH067861161100BC006786 cellular repressor ofHomo sapiens
E1A-stimulated genes
243AAH086281161100BC008628 cellular repressor ofHomo sapiens
E1A-stimulated genes
243AF0845231161100cellular repressor of E1A-Homo sapiens
stimulated genes CREG
244AX167114822099unnamed protein productHomo sapiens
244BC036531820699Unknown (protein for MGC: 33668)Homo sapiens
244Z74615822099prepro-alpha1(I) collagenHomo sapiens
245AB025412567198Ten-m3Mus musculus
245AF195418_1567699AF195418 ODZ3Mus musculus
245AK0013365447100unnamed protein productHomo sapiens
246AAH035501419100BC003550 Similar to CGI-20Homo sapiens
protein
246AF132954_1157799AF132954 CGI-20 proteinHomo sapiens
246AK003551161395unnamed protein productMus musculus
247BC02251224296platelet/endothelial cellHomo sapiens
adhesion molecule (CD31 antigen)
247L3465724296platelet endothelial cellHomo sapiens
adhesion molecule-1
247M2852624296PECAM-1 precursorHomo sapiens
248AAH121381849100BC012138 Similar to guanineHomo sapiens
nucleotide binding protein (G
protein), alpha inhibiting
activity polypeptide 2
248AF493906_11849100AF493906 guanine nucleotideHomo sapiens
binding protein alpha i2
248X048281849100G protein alpha-subunit (AA 1-355)Homo sapiens
249AF081258_13091100AF081258 testis-specificHomo sapiens
chromodomain Y-like protein
249AF081259_13091100AF081259 testis-specificHomo sapiens
chromodomain Y-like protein
249AF081261_1261488AF081261 testis-specificMus musculus
chromodomain Y-like protein
250AF162856_1514765AF162856 receptor-like proteinMus musculus
tyrosine phosphatase rho-1
250X58287756997protein-tyrosine phosphataseMus musculus
250X58288773199protein-tyrosine phosphataseHomo sapiens
251AK09699830365unnamed protein productHomo sapiens
251AK09796530473unnamed protein productHomo sapiens
251BC03395933377similar to Alu subfamily SQHomo sapiens
sequence contamination warning
entry
252AAH189911272100BC018991 hepatoma-derived growthHomo sapiens
factor (high-mobility group
protein 1-like)
252AJ237996120595hepatoma derived growth factorBos taurus
252D164311272100hepatoma-derived GFHomo sapiens
253AAH17197178599BC017197 myeloid cell leukemiaHomo sapiens
sequence 1 (BCL2-related)
253AF147742_1178599AF147742 myeloid cellHomo sapiens
differentiation protein
253AF162677178599myeloid cell leukemia protein 1Homo sapiens
254AF2748922520100glucose transporter 3Homo sapiens
254BC0391962520100solute carrier family 2Homo sapiens
(facilitated glucose
transporter), member 3
254M206812520100glucose transporter-like proteinHomo sapiens
255AAH007303448100BC000730 calpain 6Homo sapiens
255AJ000388343999calpain-like protease, CANPXHomo sapiens
255AL0311173448100dJ914P14.1 (calpain-like proteaseHomo sapiens
CANPX)
256AAH031431980100BC003143 dual specificityHomo sapiens
phosphatase 6
256AAH035621980100BC003562 dual specificityHomo sapiens
phosphatase 6
256X939201980100protein-tyrosine-phosphataseHomo sapiens
257AB0231946006100KIAA0977 proteinHomo sapiens
257AK052533354961unnamed protein productMus musculus
257AL049939182399hypothetical proteinHomo sapiens
258AAH150314447100BC015031 Unknown (protein forHomo sapiens
MGC: 9105)
258AB0182664447100KIAA0723 proteinHomo sapiens
258BC029070437598Similar to matrin 3Mus musculus
259AAH187261229100BC018726 CD74 antigen (invariantHomo sapiens
polypeptide of major
histocompatibility complex, class
II antigen-associated)
259M135601229100cell surface glycoproteinHomo sapiens
259X004971229100putative p33Homo sapiens
260AF114262_3230588AF114260 forkhead protein AFXHMus musculus
260X939962624100AFXHomo sapiens
260Y11284248997AFX1Homo sapiens
261AAH094091688100BC009409 Unknown (protein forHomo sapiens
MGC: 10655)
261X134251688100GA733-1 protein (AA 1-323)Homo sapiens
261X777541688100gp50/TROP-2Homo sapiens
262AAH02532795100BC002532 epididymal secretoryHomo sapiens
protein (19.5 kD)
262X67698795100orfHomo sapiens
262X78134795100epididymal secretory protein 14.6Macaca
fascicularis
263AK075092233100unnamed protein productHomo sapiens
264AAH166921163100BC016692 progesterone receptorHomo sapiens
membrane component 2
264AJ0020301163100progresterone binding proteinHomo sapiens
264AY06992152560membrane progesterone receptor-Oncorhynchus
like proteinmykiss
265AAH160411441100BC016041 insulin-like growthHomo sapiens
factor-binding protein 4
265M624031441100IGF-BP 4Homo sapiens
265Y125081441100insulin-like growth factorHomo sapiens
binding protein 4
266AK000575734100unnamed protein productHomo sapiens
266AK01343848472unnamed protein productMus musculus
266AY116892734100HCF-1 beta-propeller interactingHomo sapiens
protein
267AAH144102273100BC014410 Similar to EGF-Homo sapiens
containing fibulin-like
extracellular matrix protein 1
267AK077302215693unnamed protein productMus musculus
267AY0043302273100EGF-containing fibulin-likeHomo sapiens
extracellular matrix protein 1
268AF1025521106684270 kDa ankyrin G isoformRattus
norvegicus
268L40632718495ankyrin 3Mus musculus
268U136162010799ankyrin GHomo sapiens
269AC0020733406100Lim KinaseHomo sapiens
269AL1174663183100hypothetical proteinHomo sapiens
269D459063406100LIMK-2Homo sapiens
270AAH00836633100BC000836 CGI-127 proteinHomo sapiens
270AF135161_1633100AF135161 unknownHomo sapiens
270AF151885_1633100AF151885 CGI-127 proteinHomo sapiens
271A1676835679kunitz type protease inhibitorsynthetic
construct
271BC03317450198Similar to collagen, type VI,Homo sapiens
alpha 3
271X5202250198collagen type VI, alpha 3 chainHomo sapiens
272AAH04440405100BC004440 Unknown (protein forHomo sapiens
MGC: 4033)
272AAH1933642498BC019336 Unknown (protein forHomo sapiens
IMAGE: 3617778)
272U9151239998ninjurinHomo sapiens
273AAH18127125093BC018127 Similar toHomo sapiens
Peptidylglycine alpha-amidating
monooxygenase
273AB095007125093peptidylglycine alpha-amidatingHomo sapiens
monooxygenase
273AF0353201279100peptidylglycine alpha-amidatingHomo sapiens
monooxygenase
274AAH133986167100BC013398 pumilio (Drosophila)Homo sapiens
homolog 1
274AF315592_16167100AF315592 Pumilio 1Homo sapiens
274D439516233100KIAA0099 proteinHomo sapiens
275AAH00465826100BC000465 growth arrest and DNA-Homo sapiens
damage-inducible, gamma
275AAH19325826100BC019325 growth arrest and DNA-Homo sapiens
damage-inducible, gamma
275AF494037_1826100AF494037 growth arrest and DNA-Homo sapiens
damage-inducible, gamma
276AAH01955883100BC001955 ribosomal protein S10Homo sapiens
276AAH04334883100BC004334 ribosomal protein S10Homo sapiens
276AAH05012883100BC005012 ribosomal protein S10Homo sapiens
277AAH12740468799BC012740 Similar to dystroglycanHomo sapiens
1 (dystrophin-associated
glycoprotein 1)
277AAH14616468799BC014616 Unknown (protein forHomo sapiens
MGC: 3618)
277L197114703100dystroglycanHomo sapiens
278AAH20983583100BC020983 pituitary tumor-Homo sapiens
transforming 1 interacting
protein
278BC031097583100pituitary tumor-transforming 1Homo sapiens
interacting protein
278BC034250583100pituitary tumor-transforming 1Homo sapiens
interacting protein
279AAH07082185100BC007082 SWI/SNF related, matrixHomo sapiens
associated, actin dependent
regulator of chromatin, subfamily
e, member 1
279AAH11017185100BC011017 SWI/SNF related, matrixHomo sapiens
associated, actin dependent
regulator of chromatin, subfamily
e, member 1
279AF035262185100BAF57Homo sapiens
281AF0991541365686von Willebrand factorCanis
familiaris
281M258651551099von Willebrand factorHomo sapiens
281X0438515515100VWF pre-pro-polypeptide (−22 toHomo sapiens
2791)
282AAH17692150078BC017692 Similar to quiescin Q6Homo sapiens
282AF361868149278sulfhydryl oxidaseHomo sapiens
282U97276226284quiescinHomo sapiens
284AAH121231528100BC012123 golgi phosphoprotein 3Homo sapiens
284AJ2961521528100Golgi proteinHomo sapiens
284BC0337251528100golgi phosphoprotein 3 (coat-Homo sapiens
protein)
285AAH087262687100BC008726 oxidative-stressHomo sapiens
responsive 1
285AB0176422687100oxidative-stress responsive 1Homo sapiens
285AB0290242355100KIAA1101 proteinHomo sapiens
286AAH00478340399BC000478 heat shock 70 kD proteinHomo sapiens
9B (mortalin-2)
286BC024034340399heat shock 70 kD protein 9BHomo sapiens
(mortalin-2)
286BC030634339999heat shock 70 kD protein 9BHomo sapiens
(mortalin-2)
287BC006834892100B-cell translocation gene 1,Mus musculus
anti-proliferative
287BC018309892100B-cell translocation gene 1,Mus musculus
anti-proliferative
287Z16410892100btg1Mus musculus
288AE00366725681CG9318-PADrosophila
melanogaster
288AF02621324471Hypothetical protein F08F1.7Caenorhabditis
elegans
288AY06966525681LD44273pDrosophila
melanogaster
289A037363879100factor XIIIaHomo sapiens
289M143543879100clotting factor XIIIa precursorHomo sapiens
(EC 2.3.2.13)
289M14539401699factor XIII precursorHomo sapiens
290AAH0654196999BC006541 integrin, beta 5Homo sapiens
290J0563396298integrin beta-5 subunit precursorHomo sapiens
290X5300296999precusor polypeptide (AA −23 toHomo sapiens
776)
291D509297262100The KIAA0139 gene product isHomo sapiens
related to mouse centrosomin B.
291U580467262100p167Homo sapiens
291U783117262100translation initiation factor 3Homo sapiens
large subunit
292AAH015712935100BC001571 eukaryotic translationHomo sapiens
initiation factor 3, subunit 8
(110 kD)
292AC0025442935100Translation initiation factorHomo sapiens
eIF-p110
292U460252935100translation intiation factor eIF-Homo sapiens
3 p110 subunit
293AB019987651399chromosome-associatedHomo sapiens
polypeptide-C
293AF092564604199chromosome-associated protein-CHomo sapiens
293AL1368776517100hypothetical proteinHomo sapiens
294AAH01756288099BC001756 phosphoglucomutase 1Homo sapiens
294AAH19920287399BC019920 Unknown (protein forHomo sapiens
MGC: 29909)
294M83088288099PGM1Homo sapiens
295AB0206643759100KIAA0857 proteinHomo sapiens
295AF334812_13333100AF334812 Rab11 interactingHomo sapiens
protein Rip11a
295BC035013330399Similar to Rab coupling proteinHomo sapiens
296AF356518_11637100AF356518 junctional adhesionHomo sapiens
molecule 3 precursor
296AF448478_11637100AF448478 junctional adhesionalHomo sapiens
molecule-3
296AJ4161011870100junction adhesion molecule 3Homo sapiens
297AF130117_4823976AF130089 PRO2550Homo sapiens
297AK00038524076unnamed protein productHomo sapiens
297AK09098821871unnamed protein productHomo sapiens
298AAH015623284100BC001562 nuclear receptorHomo sapiens
coactivator 4
298AL1620473284100hypothetical proteinHomo sapiens
298L493993284100ORFHomo sapiens
299AAH023562379100BC002356 nucleobindin 1Homo sapiens
299M96824232698nucleobindinHomo sapiens
299U31342235799nucleobindinHomo sapiens
300AAH171804694100BC017180 Unknown (protein forHomo sapiens
MGC: 790)
300AK088028459797unnamed protein productMus musculus
300BC007126459797Unknown (protein for MGC: 5677)Mus musculus
301AAH08099378100BC008099 Unknown (protein forHomo sapiens
IMAGE: 4183312)
301AAH18427214100BC018427 Unknown (protein forHomo sapiens
IMAGE: 4515233)
302AF137053_1231099AF137053 mutant desminHomo sapiens
302BC032116231399desminHomo sapiens
302U591672325100desminHomo sapiens
303AL4457952337699heparan sulfate proteoglycanHomo sapiens
perlecan
303M852892347799heparan sulfate proteoglycanHomo sapiens
303X625152362799Human basement membrane heparanHomo sapiens
sulfate proteoglycan core protein
304AK02511620648unnamed protein productHomo sapiens
304AK05783022749unnamed protein productHomo sapiens
304AK09051119451unnamed protein productHomo sapiens
305AAH00429309100BC000429 chromosome 14 openHomo sapiens
reading frame 2
305AAH01944309100BC001944 chromosome 14 openHomo sapiens
reading frame 2
305AF054175309100mitochondrial proteolipid 68MPHomo sapiens
homolog
306AAH012632152100BC001263 serum/glucocorticoidHomo sapiens
regulated kinase
306AF153609_12152100AF153609 serine/threonine proteinHomo sapiens
kinase sgk
306AX5535492152100unnamed protein productHomo sapiens
307AAH07103710100BC007103 small acidic proteinHomo sapiens
307AAH16352710100BC016352 small acidic proteinHomo sapiens
307AAH20937710100BC020937 small acidic proteinHomo sapiens
309AY043487412100selenoprotein SelMHomo sapiens
309AY04348836785selenoprotein SelMMus musculus
309BC01974234585Unknown (protein for MGC: 30803)Mus musculus
310AF124719_11018100AF124719 GM2 activator proteinHomo sapiens
310X61095103997GM2-activator proteinHomo sapiens
310X620781018100GM2 activator proteinHomo sapiens
311AB0289741802100KIAA1051 proteinHomo sapiens
311AX0826221995100unnamed protein productHomo sapiens
311AX0826222129100unnamed protein productHomo sapiens
312BC0266903964100CD97 antigenHomo sapiens
312U76764379687CD97Homo sapiens
312X84700395199leucocyte antigen CD97Homo sapiens
313K03195242299glucose transporter glycoproteinHomo sapiens
313M13979236797glucose-transporter proteinRattus
norvegicus
313M22063236797glucose transporter proteinRattus
norvegicus
314AAH192971801100BC019297 Unknown (protein forHomo sapiens
MGC: 4111)
314AK0216551801100unnamed protein productHomo sapiens
314AK0227571801100unnamed protein productHomo sapiens
315AC0059431522100methyl-CpG binding protein MBD3Homo sapiens
315AF0722471522100methyl-CpG binding domain-Homo sapiens
containing protein MBD3
315AF072248142795methyl-CpG binding domain-Mus musculus
containing protein MBD3
316AB0180092602100L-type amino acid transporter 1Homo sapiens
316AB0185422602100CD98 light chainHomo sapiens
316AF1040322602100L-type amino acid transporterHomo sapiens
subunit LAT1
318AAH107371911100BC010737 Similar to reticulon 4Homo sapiens
318AAH126191911100BC012619 Unknown (protein forHomo sapiens
MGC: 13655)
318BC0267881911100reticulon 4Homo sapiens
319AAH02412376699BC002412 inner membrane protein,Homo sapiens
mitochondrial (mitofilin)
319D21094376699motor proteinHomo sapiens
319L425723771100transmembrane proteinHomo sapiens
320AAH01925573100BC001925 FK506-binding protein 1AHomo sapiens
(12 kD)
320AAH05147573100BC005147 FK506-binding protein 1AHomo sapiens
(12 kD)
320M93060573100FK506-binding protein 12Homo sapiens
321AF116721_20391100AF116620 PRO1068Homo sapiens
322AK075023133599unnamed protein productHomo sapiens
322AL1174421344100hypothetical proteinHomo sapiens
322BC002138130296Unknown (protein forMus musculus
IMAGE: 3484538)
323AAH07674382100BC007674 CD24 antigen (small cellHomo sapiens
lung carcinoma cluster 4 antigen)
323L33930382100signal transducer CD24Homo sapiens
323M58664382100signal transducer CD24Homo sapiens
324AAH121814260100BC012181 Similar to paired basicHomo sapiens
amino acid cleaving enzyme
(furin, membrane associated
receptor protein)
324U20436406095furin endoproteaseCricetulus
griseus
324X170944260100furin (AA 1-794)Homo sapiens
325AAH15236876100BC015236 hypothetical proteinHomo sapiens
325AF335324_1876100AF335324 RTP801Homo sapiens
325AY090097876100REDD-1Homo sapiens
326AK00049633266unnamed protein productHomo sapiens
326AK02511632769unnamed protein productHomo sapiens
326AK05783035869unnamed protein productHomo sapiens
327AAH100583813100BC010058 exostoses (multiple) 2Homo sapiens
327U627403813100EXT2Homo sapiens
327U673683813100multiple exostosis 2Homo sapiens
328AAH083011967100BC008301 tuftelin 1Homo sapiens
328AF254260_11967100AF254260 tuftelin 1Homo sapiens
328AF2548601967100tuftelin 1Homo sapiens
330AF272662_1696180AF272662 alpha 1 type V collagenRattus
norvegicus
330D90279745286collagen alpha 1(V) chainHomo sapiens
precursor
330M76729742285pro-alpha-1 type V collagenHomo sapiens
331AAH03155119376BC003155 coatomer proteinHomo sapiens
complex, subunit epsilon
331AAH07250119376BC007250 coatomer proteinHomo sapiens
complex, subunit epsilon
331AAH17285119376BC017285 Unknown (protein forHomo sapiens
MGC: 29652)
332AX354381347100unnamed protein productHomo sapiens
333AF202636_12164100AF202636 angiopoietin-likeHomo sapiens
protein PP1158
333AX0799712164100unnamed protein productHomo sapiens
333BC0236472164100angiopoietin-like 4Homo sapiens
334AAH12777162100BC012777 Unknown (protein forHomo sapiens
MGC: 16395)
334AK0567671189100unnamed protein productHomo sapiens
334AL83191371385hypothetical proteinHomo sapiens
335AAH012701896100BC001270 SH3-domain GRB2-like 1Homo sapiens
335U659991896100SH3-containing protein EENHomo sapiens
335X996561896100SH3-containing Grb-2-like 1Homo sapiens
336AAH003854505100BC000385 Unknown (protein forHomo sapiens
MGC: 8429)
336AF1028034505100alphaE-cateninHomo sapiens
336D138664505100alpha-cateninHomo sapiens
337AAH0756460190BC007564 annexin AllHomo sapiens
337AJ27846460190annexin AllHomo sapiens
337AJ27846560190annexin AllHomo sapiens
338AAH01491147099BC001491 heme oxygenaseHomo sapiens
(decycling) 1
338X069851475100heme oxygenase (AA 1-288)Homo sapiens
338Z822441475100bK286B10.2 (Heme OxygenaseHomo sapiens
(decycling) 1 (HO-1 EC
1.14.99.3))
340AAH139101671100BC013910 Similar to deathHomo sapiens
effector domain-containing
340AAH167241671100BC016724 death effector domain-Homo sapiens
containing
340AJ0109731671100DEDD proteinHomo sapiens
341A1679488195cDNA isolated for this proteinHomo sapiens
using a monoclonal antibody
directed against the p27k
prosomal protein
341BC02235495697proteasome (prosome, macropain)Homo sapiens
subunit, alpha type 6
341D1075595697proteasome subunit R-IOTARattus sp.
342AAH095812041100BC009581 hydroxysteroid (17-beta)Homo sapiens
dehydrogenase 2
342L11708204110017 beta hydroxysteroidHomo sapiens
dehydrogenase type 2
342L40802204110017-hydroxysteroid dehydrogenaseHomo sapiens
343AAH08452586100BC008452 ATPase, H+ transporting,Homo sapiens
lysosomal (vacuolar proton pump),
member J
343AF038954586100vacuolar H(+)-ATPase subunitHomo sapiens
343S8246457396vacuolar H(+)-ATPase subunit; V-Bos taurus
ATPase subunit; M16
344AE00345219335CG9350-PBDrosophila
melanogaster
344AJ51014857172mitochondrial NADH: ubiquinoneBos taurus
oxidoreductase B14.7 subunit
344AK00820153265unnamed protein productMus musculus
345AB0206853216100KIAA0878 proteinHomo sapiens
345AK006650206593unnamed protein productMus musculus
345BC041337321299Rho-related BTB domain containing 3Homo sapiens
346AB0587491868100KIAA1846 proteinHomo sapiens
346AK0922951868100unnamed protein productHomo sapiens
346AL0356611868100dJ568C11.3 (novel AMP-bindingHomo sapiens
enzyme similar to acetyl-coenzyme
A synthethase (acetate-coA
ligase))
347AF0092421168100proline-rich Gla protein 1Homo sapiens
347AF41915457752mitotic phosphoprotein 77Xenopus
laevis
347BC030786116984proline-rich Gla (G-Homo sapiens
carboxyglutamic acid) polypeptide 1
348AF000652150399synteninHomo sapiens
348AF0066361508100melanoma differentiationHomo sapiens
associated protein-9
348U83463150399scaffold protein Pbp1Homo sapiens
349AF312032520099ephrin type-B receptor 4Homo sapiens
precursor
349AY056047520099receptor protein tyrosine kinaseHomo sapiens
EphB4
349U07695519699tyrosine kinaseHomo sapiens
350AF015553495599TFII-I proteinHomo sapiens
350AF038969494999general transcription factor 2-IHomo sapiens
350Y14946494999SPIN proteinHomo sapiens
351AAH074521442100BC007452 Similar to WW domainHomo sapiens
binding protein 2
351AAH106161442100BC010616 Unknown (protein forHomo sapiens
MGC: 18269)
351U794581458100WW domain binding protein-2Homo sapiens
352AB097511399693hypothetical proteinMacaca
fascicularis
352AL359292737399dJ448K1.1.1 (absent in melanomaHomo sapiens
1, isoform 1)
352U831158577100non-lens beta gamma-crystallinHomo sapiens
like protein
353AAH0592135786BC005921 chorionicHomo sapiens
somatomammotropin hormone 1
(placental lactogen)
353AAH2075635786BC020756 chorionicHomo sapiens
somatomammotropin hormone 1
(placental lactogen)
353AAH2204435786BC022044 chorionicHomo sapiens
somatomammotropin hormone 2
354AY158924650100histone protein Hist2h2aa2Mus musculus
354AY158925650100histone protein Hist2h2aa1Mus musculus
354AY158953650100histone protein Hist2h3c2Mus musculus
355AF226614_12929100AF226614 ferroportin1Homo sapiens
355AF231121_12929100AF231121 iron-regulatedHomo sapiens
transporter IREG1
355BC0377332929100solute carrier family 11 (proton-Homo sapiens
coupled divalent metal ion
transporters), member 3
356AAH01693709100BC001693 lectin, galactoside-Homo sapiens
binding, soluble, 1 (galectin 1)
356AAH20675709100BC020675 lectin, galactoside-Homo sapiens
binding, soluble, 1 (galectin 1)
356X14829709100beta-galactoside-binding lectinHomo sapiens
(AA 1-135)
357AF15179452139pol proteinPhascolarctos
cinereus
357AJ29365749637polymerasePorcine
endogenous
type C
retrovirus
357M2692751739pol polyproteinGibbon ape
leukemia
virus
358AAD1807668999AF129756 G6cHomo sapiens
358AJ01200868999Ly6-C proteinHomo sapiens
358AJ31553368999LY6G6C proteinHomo sapiens
359AAH116822559100BC011682 Similar to cathepsin FHomo sapiens
359AF132894_12559100AF132894 cathepsin FHomo sapiens
359AJ0073312559100cysteine proteinaseHomo sapiens
360AF151048_140787AF151048 HSPC214Homo sapiens
360AF247565_142391AF247565 anaphase promotingHomo sapiens
complex subunit 11
360AF247789_142391AF247789 putative anaphase-Homo sapiens
promoting complex subunit APC11
361AAH1181155992BC011811 Unknown (protein forHomo sapiens
MGC: 20260)
361AF218016_143276AF218016 unknownHomo sapiens
362AAH1720163498BC017201 insulin-like growthHomo sapiens
factor binding protein 7
362L1918263498MAC25Homo sapiens
362S7572563498prostacyclin-stimulating factor;Homo sapiens
PGI2-stimulating factor; PSF
364AF126110_164396AF126110 fibulin-1 isoform DHomo sapiens
precursor
364BC02249764396fibulin 1Homo sapiens
364U0124464396fibulin-1DHomo sapiens
365AAH0583941497BC005839 follistatin-like 3Homo sapiens
(secreted glycoprotein)
365BC03311941497follistatin-like 3 (secretedHomo sapiens
glycoprotein)
365U7670241497follistatin-related protein FLRGHomo sapiens
366AAH0016360199BC000163 vimentinHomo sapiens
366BC03057360199Unknown (protein for MGC: 16183)Homo sapiens
366X5613460199vimentinHomo sapiens
367AB0182655555100KIAA0722 proteinHomo sapiens
367AF0454585460100serine/threonine kinase ULK1Homo sapiens
367AF072370_1486589AF072370 UNC51.1 serine/threonineMus musculus
kinase
368AAH00865227100BC000865 Unknown (protein forHomo sapiens
IMAGE: 3460093)
369AAH0297827991BC002978 CD81 antigen (target ofHomo sapiens
antiproliferative antibody 1)
369AF11660027991CD81Pan
troglodytes
369M336802799126-kDa cell surface protein TAPA-1Homo sapiens
370AAH15156678100BC015156 ferritin, heavyHomo sapiens
polypeptide 1
370AAH16009678100BC016009 ferritin, heavyHomo sapiens
polypeptide 1
370AAH16857678100BC016857 ferritin, heavyHomo sapiens
polypeptide 1
371AAH0801229867BC008012 eukaryotic translationHomo sapiens
elongation factor 1 delta
(guanine nucleotide exchange
protein)
371AAH0990729867BC009907 eukaryotic translationHomo sapiens
elongation factor 1 delta
(guanine nucleotide exchange
protein)
371AAH1281929867BC012819 eukaryotic translationHomo sapiens
elongation factor 1 delta
(guanine nucleotide exchange
protein)
372AAH2075647083BC020756 chorionicHomo sapiens
somatomammotropin hormone 1
(placental lactogen)
372AAH2204447083BC022044 chorionicHomo sapiens
somatomammotropin hormone 2
372M1589446192chorionic somatomammotropinHomo sapiens
precursor
373A65264705100unnamed protein productunidentified
373AAH0128857493BC001288 Similar to decayHomo sapiens
accelerating factor for
complement (CD55, Cromer blood
group system)
373M3151657493decay-accelerating factorHomo sapiens
374AF289553_119375AF289553 unknownHomo sapiens
374AK09699820264unnamed protein productHomo sapiens
374AK09734220778unnamed protein productHomo sapiens
375AAH0532649998BC005326 ribosomal protein L27aHomo sapiens
375AAH2016949998BC020169 Unknown (protein forHomo sapiens
IMAGE: 3543815)
375U1496849998ribosomal protein L27aHomo sapiens
377AAH2129728291BC021297 Similar to Dynein heavyHomo sapiens
chain 64C
377AB00232328291KIAA0325Homo sapiens
377AY00487726794cytoplasmic dynein heavy chainMus musculus
378BC026018643100Similar to laminin, beta 1Homo sapiens
378M20206643100laminin B1Homo sapiens
378M55370643100laminin B1Homo sapiens
379AF06165858591cytidine deaminaseHomo sapiens
379AJ00047458591cytidine deaminaseHomo sapiens
379L2794358591cytidine deaminaseHomo sapiens
380AAH1898641273BC018986 Unknown (protein forHomo sapiens
MGC: 20092)
380AF22983041273prostaglandin dehydrogenasePapio
hamadryas
380U632964127315-hydroxyprostaglandinHomo sapiens
dehydrogenase
381AAH00749507100BC000749 lactate dehydrogenase AHomo sapiens
381AAH01829507100BC001829 lactate dehydrogenase AHomo sapiens
381X03077507100lactate dehydrogenase-AHomo sapiens
382AAH0090374984BC000903 high-mobility groupHomo sapiens
(nonhistone chromosomal) protein 2
382AAH0106374984BC001063 high-mobility groupHomo sapiens
(nonhistone chromosomal) protein 2
382X6253474984HMG-2Homo sapiens
383AK07521433891unnamed protein productHomo sapiens
383AX41752633891unnamed protein productHomo sapiens
383AX41752833891unnamed protein productHomo sapiens
384AF13506073596fibrillin-2Rattus
norvegicus
384U0327274599fibrillin-2Homo sapiens
384X6200974598fibrillin 5Homo sapiens
385AAH13083478100BC013083 Similar to cystatin CHomo sapiens
(amyloid angiopathy and cerebral
hemorrhage)
385X12763478100ompA - cystatin C fusionsynthetic
preprotein (AA −21 to 120)construct
385X61681478100cystatin CHomo sapiens
387AF13506052389fibrillin-2Rattus
norvegicus
387L3979053290fibrillin 2Mus musculus
387U03272597100fibrillin-2Homo sapiens
388M65149120085CELFRattus
norvegicus
388M836671430100NF-IL6-beta proteinHomo sapiens
388S63168141899CCAAT/enhancer-binding proteinHomo sapiens
delta; C/EBP delta
389AF186111_122852AF186111 NOTCH4-like proteinHomo sapiens
389AL51273522852hypothetical proteinHomo sapiens
389AX13383122852unnamed protein productHomo sapiens
390M1345264190lamin A proteinHomo sapiens
390X0344463195put. lamin A precursor (aa 1-702)Homo sapiens
390X6687062984lamin ARattus
norvegicus
391U1463124410011 beta-hydroxysteroidHomo sapiens
dehydrogenase type II
391U2672624410011-beta-hydroxysteroidHomo sapiens
dehydrogenase type 2
391U2731724410011 beta-hydroxysteroidHomo sapiens
dehydrogenase 2
392AB049946666100mitochondrial ribosomal proteinHomo sapiens
S15
392AF265439_1415100AF265439 DC37Homo sapiens
392BC031336666100mitochondrial ribosomal proteinHomo sapiens
S15
393AAH1373333392BC013733 px19-like proteinHomo sapiens
393AAH1374833392BC013748 px19-like proteinHomo sapiens
393AF201925_133392AF201925 PRELIHomo sapiens
394AAH02362694100BC002362 lactate dehydrogenase BHomo sapiens
394AAH15122694100BC015122 lactate dehydrogenase BHomo sapiens
394Y00711694100lactate dehydrogenase B (AA 1-334)Homo sapiens
395AAH0307042776BC003070 GATA-binding protein 3Homo sapiens
395AAH0679342776BC006793 GATA-binding protein 3Homo sapiens
395X5503742776GATA-3Homo sapiens
396AF269289_128794AF269289 unknownHomo sapiens
397AAH0772837680BC007728 Unknown (protein forHomo sapiens
MGC: 12671)
397AL08010237680hypothetical proteinHomo sapiens
397U4943637680translation initiation factor 5Homo sapiens
398AAH0319047294BC003190 p75NTR-associated cellHomo sapiens
death executor; ovarian granulosa
cell protein (13 kD)
398AF18704_147294AF187064 p75NTR-associated cellHomo sapiens
death executor; NADE
398M3818847294unknownHomo sapiens
399AB037767542799KIAA1346 proteinHomo sapiens
399AF207664_15274100AF207664 matrix metalloproteaseHomo sapiens
399AP0016975274100metalloprotease withHomo sapiens
thrombospondin type 1 motifs
400U9093821376Fc gamma receptor IIc1Homo sapiens
400X1765221376IgG Fc receptorHomo sapiens
400X1765221376IgG Fc receptorHomo sapiens
401AAH0176839093BC001768 neuronatinHomo sapiens
401AL10961439093bA425M5.3.1 (neuronatin (isoformHomo sapiens
1))
401U3176739093neuronatin alphaHomo sapiens
402AF151373_132882AF151373 nucleolin-relatedRattus
protein NRPnorvegicus
402M1582528173nucleolin, C23Cricetulus
griseus
402M5502228675nucleolinRattus
norvegicus
403AAH1342855886BC013428 PP1201 proteinHomo sapiens
403AF193045_155886AF193045 unknownHomo sapiens
403BC02634855886PP1201 proteinHomo sapiens
404AF393832_172194AF393832 beta-actinMorulius
calbasu
404AY03965772194beta-actinChrysophrys
auratus
404AY14835072194actinDicentrarchus
labrax
405AK05559337098unnamed protein productHomo sapiens
406AAH212331036100BC021233 ATP synthase, H+Homo sapiens
transporting, mitochondrial F1
complex, O subunit (oligomycin
sensitivity conferring protein)
406BC0228651036100ATP synthase, H+ transporting,Homo sapiens
mitochondrial F1 complex, O
subunit (oligomycin sensitivity
conferring protein)
406X832181036100ATP synthase, oligomycinHomo sapiens
sensitivity conferring protein
407AAH04368122199BC004368 proteasome (prosome,Homo sapiens
macropain) activator subunit 2
(PA28 beta)
407AAH19885122199BC019885 proteasome (prosome,Homo sapiens
macropain) activator subunit 2
(PA28 beta)
407D452481226100proteasome activator hPA28 suunitHomo sapiens
beta
408AF0903062306100retinoblastoma binding proteinRattus
norvegicus
408U351432306100retinoblastoma-binding proteinHomo sapiens
RbAp46
408X728412306100IEF 7442Homo sapiens
409AAH004131748100BC000413 eukaryotic translationHomo sapiens
initiation factor 3, subunit 2
(beta, 36 kD)
409AAH031401748100BC003140 eukaryotic translationHomo sapiens
initiation factor 3, subunit 2
(beta, 36 kD)
409U390671748100translation initiation factorHomo sapiens
eIF3 p36 subunit
410AF04216613721100beta-filaminHomo sapiens
410AF0430451370999actin-binding protein homologHomo sapiens
ABP-278
410AF19163313721100filaminHomo sapiens
411AF165515_11862100AF165515 ancient ubiquitousHomo sapiens
protein 1 precursor
411AK0239831935100unnamed protein productHomo sapiens
411BC0336461862100ancient ubiquitous protein 1Homo sapiens
412AB0098651347100Angiopoietin-2Homo sapiens
412AF187858_1133599AF187858 angiopoietin-2 isoform-1Homo sapiens
412AF218015_11347100AF218015 unknownHomo sapiens
413AF03571891499mesoderm-specific basic-helix-Homo sapiens
loop-helix protein; Pod-1
413AL356109917100bA373A10.1 (transcription factorHomo sapiens
21)
413BC025697917100transcription factor 21Homo sapiens
414M386901200100CD9 antigenHomo sapiens
414S604891200100CD9 antigenHomo sapiens
414X601111200100MRP-1 (motility related protein)Homo sapiens
415AAH02368462999BC002368 proteasome (prosome,Homo sapiens
macropain) 26S subunit, non-
ATPase, 2
415AAH02997462999BC002997 proteasome (prosome,Homo sapiens
macropain) 26S subunit, non-
ATPase, 2
415D781514637100human 26S proteasome subunit p97Homo sapiens
416AAH001821622100BC000182 annexin A4Homo sapiens
416AAH116591622100BC011659 Similar to annexin A4Homo sapiens
416D781521622100annexin IV (carbohydrtate-bindingHomo sapiens
protein p33/41)
417AAH03064401699BC003064 disabled (Drosophila)Homo sapiens
homolog 2 (mitogen-responsive
phosphoprotein)
417AF2058904028100disabled-2Homo sapiens
417U390504028100DOC-2Homo sapiens
418AAH07075780100BC007075 hemoglobin, betaHomo sapiens
418U01317780100beta-globinHomo sapiens
418V00499780100beta globinHomo sapiens
419AAH21557409399BC021557 transmembrane protein 8Homo sapiens
(five membrane-spanning domains)
419AB0452924100100M83 proteinHomo sapiens
419AE006463_7408899AE006463 M83Homo sapiens
420AF193048_1946100AF193048 unknownHomo sapiens
421AF151980_12009100AF151980 connexin 43Homo sapiens
421BC0263292009100gap junction protein, alpha 1,Homo sapiens
43 kD (connexin 43)
421X529472009100gap junction protein (AA 1-382)Homo sapiens
422AJ3134631258100adipsin/complement factor DHomo sapiens
precursor
422BC0345291249100Unknown (protein forHomo sapiens
IMAGE: 4780594)
422M84526119898adipsin/complement factor DHomo sapiens
423AF258549_1533100AF258549 PP1292Homo sapiens
424AF217963_1421599AF217963 NRAGEHomo sapiens
424AF258554_14223100AF258554 PP2250Homo sapiens
424BC0324734223100melanoma antigen, family D, 1Homo sapiens
425AAH14635635100BC014635 Similar to SH3-domain,Homo sapiens
GRB2-like, endophilin B2
425AF257319_1635100AF257319 SH3-containing proteinHomo sapiens
SH3GLB2
425AF258589_1635100AF258589 PP578Homo sapiens
426AAH03390707100BC003390 hypothetical proteinHomo sapiens
426AAH14334707100BC014334 Unknown (protein forHomo sapiens
MGC: 22874)
426AF275807_1822100AF275807 PNAS-110Homo sapiens
427AAH05238469100BC005238 FXYD domain-containingHomo sapiens
ion transport regulator 3
427U282494117511 kD proteinHomo sapiens
427X93036469100MAT8 proteinHomo sapiens
428AF0144021500100type-2 phosphatidic acidHomo sapiens
phosphatase alpha-1
428BC0398471500100Similar to phosphatidic acidHomo sapiens
phosphatase type 2A
428Y144361500100phosphatidic acid phosphataseHomo sapiens
type 2
429AL163249272999T-complex protein 1 theta subunitHomo sapiens
429D13627273099KIAA0002Homo sapiens
429D420522734100predicted protein of 548 aminoHomo sapiens
acids
430AAH013122306100BC001312 protein disulfideHomo sapiens
isomerase-related protein
430BC006865222095Similar to protein disulfideMus musculus
isomerase-related protein
430D494892306100human P5Homo sapiens
431AF439513_1791791AF439513 pregnancy-associatedMus musculus
plasma protein-A
431U287278980100pregnancy-associated plasmaHomo sapiens
protein-A preproform
431X682808574100unnamed protein productHomo sapiens
432AAH019361357100BC001936 Similar to BCL2-Homo sapiens
associated athanogene
432AAH147741357100BC014774 Unknown (protein forHomo sapiens
MGC: 17086)
432AF0222241357100Bcl-2-binding proteinHomo sapiens
433AAH044901953100BC004490 v-fos FBJ murineHomo sapiens
osteosarcoma viral oncogene
homolog
433AF1111671953100cfosHomo sapiens
433V015121953100c-fosHomo sapiens
434AAH20235328299BC020235 Unknown (protein forHomo sapiens
MGC: 31939)
434M196453314100GRP78 precursorHomo sapiens
434X879493314100BiPHomo sapiens
435AAH144332640100BC014433 Unknown (protein forHomo sapiens
MGC: 2159)
435BC0360002640100Unknown (protein forHomo sapiens
IMAGE: 4712175)
435U420682640100P58Homo sapiens
436BC0327221478100tumor necrosis factor (ligand)Homo sapiens
superfamily, member 10
436U375181478100TNF-related apoptosis inducingHomo sapiens
ligand TRAIL
436U570591478100Apo-2 ligandHomo sapiens
437AAH010221591100BC001022 pyrophosphataseHomo sapiens
(inorganic)
437AF119665_11591100AF119665 inorganicHomo sapiens
pyrophosphatase
437AF217186_11591100AF217186 inorganicHomo sapiens
pyrophosphatase 1
438AAH087433145100BC008743 zyxinHomo sapiens
438AAH093603145100BC009360 zyxinHomo sapiens
438AAH100313145100BC010031 zyxinHomo sapiens
439AAH05901919100BC005901 Microfibril-associatedHomo sapiens
glycoprotein-2
439AF084927919100microfibril-associatedHomo sapiens
glycoprotein 2
439U37283919100microfibril-associatedHomo sapiens
glycoprotein-2 MAGP-2
440AAH009332015100BC000933 isocitrate dehydrogenaseHomo sapiens
3 (NAD+) gamma
440Z681292015100NAD(H)-specific isocitrateHomo sapiens
dehydrogenase gamma-subunit
precursor
440Z689072015100NAD (H)-specific isocitrateHomo sapiens
dehydrogenase gamma subunit
precursor
441AAH12265846100BC012265 Similar to cofilin 1,Homo sapiens
non-muscle
441AAH12318846100BC012318 Similar to cofilin 1,Homo sapiens
non-muscle
441AAH18256846100BC018256 Similar to cofilin 1,Homo sapiens
non-muscle
442AB069964861100ubiquitin-conjugating enzyme 9Gallus
gallus
442AF461016_1861100AF461016 ubiquitin-conjugatingGallus
enzymegallus
442U88561861100E2 ubiquitin conjugating enzymeXenopus
laevis
443AAH06249989100BC006249 guanylate kinase 1Homo sapiens
443AAH09914989100BC009914 guanylate kinase 1Homo sapiens
443U66895989100guanylate kinaseHomo sapiens
445AAH01120136999BC001120 lectin, galactoside-Homo sapiens
binding, soluble, 3 (galectin 3)
445AF031425136999galectin 3Homo sapiens
445M353681377100galactose-specific lectinHomo sapiens
446AAH0087761588BC000877 hypothetical proteinHomo sapiens
PP5395
446AF218019_161588AF218019 unknownHomo sapiens
446AF241786_11125100AF241786 NPD013Homo sapiens
447AAH0250354770BC002503 spermidine/spermine N1-Homo sapiens
acetyltransferase
447AAH0842454770BC008424 spermidine/spermine N1-Homo sapiens
acetyltransferase
447AF251292_11059100AF251292 DC21Homo sapiens
448AF135157_174569AF135157 complement C1q A chainHomo sapiens
precursor
448AF260332_11550100AF260332 DC33Homo sapiens
448BC03015374569complement component 1, qHomo sapiens
subcomponent, alpha polypeptide
449AAH00589770100BC000589 CGI-39 protein; cellHomo sapiens
death-regulatory protein GRIM19
449AAH09189770100BC009189 CGI-39 protein; cellHomo sapiens
death-regulatory protein GRIM19
449AF261134_11196100AF261134 CDA016Homo sapiens
450AAH12296113599BC012296 hypothetical proteinHomo sapiens
FLJ21174
450AF271783_11141100AF271783 NPD017Homo sapiens
450AF314542_11141100AF314542 B lymphocyte activation-Homo sapiens
related protein
451AK0904271394099FLJ00343 proteinHomo sapiens
451L4414014011100filaminHomo sapiens
451X534161400499actin-binding proteinHomo sapiens
452AAH123411492100BC012341 Similar to M5-14 proteinHomo sapiens
452AL1366221492100hypothetical proteinHomo sapiens
452AL3900901492100c3orf1 hypothetical protein, M5-14Homo sapiens
similar to (AE003703)140up
gene product Drosophila
melanogaster
453AC005624824100MY18_HUMANHomo sapiens
453AF078077824100growth arrest and DNA-damage-Homo sapiens
inducible protein GADD45beta
453AF087853_1824100AF087853 growth arrest and DNAHomo sapiens
damage inducible protein beta
454AF020185478100protein inhibitor of nitric oxideMus musculus
synthase
454BC008106478100dynein, cytoplasmic, lightMus musculus
polypeptide
454BC034258478100dynein, cytoplasmic, lightMus musculus
polypeptide
455AAH015391466100BC001539 dickkopf (XenopusHomo sapiens
laevis) homolog 1
455AF177394_11466100AF177394 dickkopf-1Homo sapiens
455AF2611581466100dickkopf homolog 1Homo sapiens
456AAC332791396100AC005559 basiginHomo sapiens
456AAH090401396100BC009040 basigin (OK blood group)Homo sapiens
456AF0428551396100EMMPRINHomo sapiens
457L471253057100glypicanHomo sapiens
457L471763057100GTR2-2 gene productHomo sapiens
457Z379873057100MXR7Homo sapiens
458D83476430677Xtld proteinXenopus
laevis
458L24755494892bone morphogenetic proteinMus musculus
458U503305416100procollagen C-proteinaseHomo sapiens
459AAH01287669100BC001287 histidine triadHomo sapiens
nucleotide-binding protein
459AAH07090669100BC007090 histidine triadHomo sapiens
nucleotide-binding protein
459U51004669100protein kinase C inhibitorHomo sapiens
460AB003306128094PSMB5Mus musculus
460AF060091_1128094AF060091 proteasome subunit XMus musculus
460X955861370100proteasomeHomo sapiens
461AF102848_12178100AF102848 keratin 23Homo sapiens
461AK002047215198unnamed protein productHomo sapiens
461BC028356215599type I intermediate filamentHomo sapiens
cytokeratin
462AAH000973483100BC000097 transforming growthHomo sapiens
factor, beta-induced, 68 kD
462AAH049723483100BC004972 transforming growthHomo sapiens
factor, beta-induced, 68 kD
462AY1493443483100transforming growth factor, beta-Homo sapiens
induced, 68 kDa
463AF414110_1635100AF414110 histone variant H2A.F/ZDanio rerio
463AF414111_1635100AF414111 histone variant H2A.F/ZDanio rerio
463V00414635100histone H2AGallus
gallus
464BC011457957100Unknown (protein for MGC: 7976)Mus musculus
464BC019761957100putative membrane proteinMus musculus
464BC020098957100putative membrane proteinMus musculus
465AAH001403579100BC000140 propionyl Coenzyme AHomo sapiens
carboxylase, alpha polypeptide
465AF385926_13579100AF385926 propionyl-CoAHomo sapiens
carboxylase alpha subunit
465AY0358083579100propionyl-CoA carboxylase alphaHomo sapiens
polypeptide precursor
466AF372216_156299AF372216 tropomyosin alphaRattus
isoformnorvegicus
466M19267565100tropomyosinHomo sapiens
466M19715565100skeletal muscle tropomyosinHomo sapiens
467AAH00191704100BC000191 hypothetical proteinHomo sapiens
467AAH14329704100BC014329 Unknown (protein forHomo sapiens
MGC: 22862)
467AF212248_1704100AF212248 CDA09Homo sapiens
468AAH00255783100BC000255 Unknown (protein forHomo sapiens
MGC: 2495)
468AF320778_1783100AF320778 cervical cancer oncogene 3Homo sapiens
468AY032594783100hepatitis C virus core-bindingHomo sapiens
protein 6
469AAH00271799100BC000271 Unknown (protein forHomo sapiens
MGC: 3204)
469AAH01434799100BC001434 Unknown (protein forHomo sapiens
MGC: 2477)
469AK00739044982unnamed protein productMus musculus
470AAH004211243100BC000421 lysosomal-associatedHomo sapiens
protein transmembrane 4 alpha
470AAH03158124099BC003158 lysosomal-associatedHomo sapiens
protein transmembrane 4 alpha
470D146961243100KIAA0108Homo sapiens
471AAH004611738100BC000461 eukaryotic translationHomo sapiens
initiation factor 2, subunit 2
(beta, 38 kD)
471AAH00934173599BC000934 eukaryotic translationHomo sapiens
initiation factor 2, subunit 2
(beta, 38 kD)
471AL0316681738100dJ64K7.2 (eukaryotic translationHomo sapiens
initiation factor 2, subunit 2
(beta, 38 kD))
472AAH004661059100BC000466 NADH dehydrogenaseHomo sapiens
(ubiquinone) 1 beta subcomplex, 8
(19 kD, ASHI)
472AAH192761059100BC019276 NADH dehydrogenaseHomo sapiens
(ubiquinone) 1 beta subcomplex, 8
(19 kD, ASHI)
472AF0449581059100NADH: ubiquinone oxidoreductaseHomo sapiens
ASHI subunit
473AAH004901821100BC000490 eukaryotic translationHomo sapiens
initiation factor 3, subunit 5
(epsilon, 47 kD)
473AK095574177498unnamed protein productHomo sapiens
473U948551821100translation initiation factor 3Homo sapiens
47 kDa subunit
474AAH00502970100BC000502 ribosomal protein L17Homo sapiens
474AAH17831970100BC017831 ribosomal protein L17Homo sapiens
474X53777970100putative ribosomal protein (AA 1-184)Homo sapiens
475AAH00505808100BC000505 microsomal glutathioneHomo sapiens
S-transferase 3
475AAH03034808100BC003034 microsomal glutathioneHomo sapiens
S-transferase 3
475AAH05964808100BC005964 microsomal glutathioneHomo sapiens
S-transferase 3
476AAH005091425100BC000509 proteasome (prosome,Homo sapiens
macropain) subunit, beta type, 7
476AAH171161393100BC017116 proteasome (prosome,Homo sapiens
macropain) subunit, beta type, 7
476D38048142199proteasome subunit zHomo sapiens
477BC0330154539100RAS p21 protein activator (GTPaseHomo sapiens
activating protein) 1
477M233794539100GTPase-activating proteinHomo sapiens
477M236124555100GTPase-activating proteinHomo sapiens
478BC0038602254100protease (prosome, macropain) 26SMus musculus
subunit, ATPase 1
478D506962254100proteasomal ATPase (S4)Rattus
norvegicus
478U393022254100P26s4Mus musculus
479AAH005222131100BC000522 Similar to serine (orHomo sapiens
cysteine) proteinase inhibitor,
clade F (alpha-2 antiplasmin,
pigment epithelium derived
factor). member 1
479AF400442_1212599AF400442 pigment epithelium-Homo sapiens
derived factor
479M76979211999pigment epithelial-Homo sapiens
differentiating factor
480AAH005291616100BC000529 prostate differentiationHomo sapiens
factor
480AAH089621616100BC008962 Unknown (protein forHomo sapiens
MGC: 4145)
480AF003934161399prostate differentiation factorHomo sapiens
481AAH00548806100BC000548 receptor (calcitonin)Homo sapiens
activity modifying protein 1
481AF181550_159671AF181550 receptor activityRattus
modifying protein 1norvegicus
481AJ001014806100RAMP1Homo sapiens
482AAH005541409100BC000554 Similar to integralHomo sapiens
membrane protein 2B
482AF136973_11409100AF136973 putative transmembraneHomo sapiens
protein E3-16
482AF152462_11409100AF152462 transmembrane proteinHomo sapiens
BRI
483AAH00601479100BC000601 DKFZP564K247 proteinHomo sapiens
483AAH09583479100BC009583 DKFZP564K247 proteinHomo sapiens
483AAH09594479100BC009594 DKFZP564K247 proteinHomo sapiens
484AAH00691906100BC000691 brain specific proteinHomo sapiens
484AF132972_190299AF132972 CGI-38 proteinHomo sapiens
484BC01078888896RIKEN cDNA 2700055K07 geneMus musculus
485AAH00720798100BC000720 ubiquitously-expressedHomo sapiens
transcript
485AAH08890798100BC008890 ubiquitously-expressedHomo sapiens
transcript
485AF092737_1798100AF092737 ubiquitously expressedHomo sapiens
transcript
486AAH01016958100BC001016 NADH dehydrogenaseHomo sapiens
(ubiquinone) 1 alpha subcomplex,
8 (19 kD, PGIV)
486AF044953_1958100AF044953 NADH: ubiquinoneHomo sapiens
oxidoreductase PGIV subunit
486X596978668819 kDa subunit of NADH: ubiquinoneBos taurus
oxidoreductase complex (complex
I)
487AAH01066763100BC001066 hypothetical proteinHomo sapiens
487AAH21986763100BC021986 mitochondrial ribosomalHomo sapiens
protein L27
487AB049647763100mitochondrial ribosomal proteinHomo sapiens
L27 (L27mt)
488AAH011012975100BC001101 HSPC025Homo sapiens
488AAH075102975100BC007510 HSPC025Homo sapiens
488BC0292652975100eukaryotic translation initiationHomo sapiens
factor 3, subunit 6 interacting
protein
489AAH011502803100BC001150 metalloprotease 1Homo sapiens
(pitrilysin family)
489AAH05025280299BC005025 Similar toHomo sapiens
metalloprotease 1 (pitrilysin
family)
489AB0290272803100KIAA1104 proteinHomo sapiens
490AAH012882064100BC001288 Similar to decayHomo sapiens
accelerating factor for
complement (CD55, Cromer blood
group system)
490M301422064100decay-accelerating factor AHomo sapiens
490M315162064100decay-accelerating factorHomo sapiens
491AAH01387833100BC001387 similar to rat HREV107Homo sapiens
491AB030814833100H-REV107 protein homologHomo sapiens
491AF317086833100HREV107-3Homo sapiens
492AAH01420800100BC001420 HN1 proteinHomo sapiens
492AF177862_1800100AF177862 HN1 proteinHomo sapiens
492AF348672800100hematological and neurologicalHomo sapiens
expressed 1 protein
493AAH01426482100BC001426 Similar to ubiquinol-Homo sapiens
cytochrome c reductase hinge
protein
493AAH01934482100BC001934 Similar to ubiquinol-Homo sapiens
cytochrome c reductase hinge
protein
493AAH15177482100BC015177 Unknown (protein forHomo sapiens
MGC: 10149)
494AAH21173429100BC021173 normal mucosa ofHomo sapiens
esophagus specific 1
494AB026707429100FOAP-11 proteinHomo sapiens
494AF228422_1429100AF228422 normal mucosa ofHomo sapiens
esophagus specific 1
495AAH15173608100BC015173 ribosomal protein,Homo sapiens
large, P0
495AAH15690608100BC015690 ribosomal protein,Homo sapiens
large, P0
495AF274958_1737100AF274958 PNAS-101Homo sapiens
496AAH149081453100BC014908 stem-loop (histone)Homo sapiens
binding protein
496AAH157031453100BC015703 stem-loop (histone)Homo sapiens
binding protein
496Z711881453100histone RNA hairpin-bindingHomo sapiens
protein
497AB0004912046100proteasome p45/SUGRattus
norvegicus
497D835212046100proteasomal ATPase (rat SUG1)Rattus
norvegicus
497Z542192046100mSUG1 proteinMus musculus
498AK075215831100unnamed protein productHomo sapiens
499AAH02481480100BC002481 HSPC162 proteinHomo sapiens
499AF132750_1480100AF132750 bithoraxoid-like proteinHomo sapiens
499AF178431_1480100AF178431 BITHHomo sapiens
500AAH025593087100BC002559 high-glucose-regulatedHomo sapiens
protein 8
500AK083882307799unnamed protein productMus musculus
500BC014797307799Unknown (protein for MGC: 11691)Mus musculus
501AAH025892230100BC002589 proteasome (prosome,Homo sapiens
macropain) 26S subunit, ATPase, 2
501BC005462222699proteasome (prosome, macropain)Mus musculus
26S subunit, ATPase 2
501D110942230100MSS1 proteinHomo sapiens
502AAH026341769100BC002634 Unknown (protein forHomo sapiens
MGC: 4272)
502AK003354173296unnamed protein productMus musculus
502BC002128172596Unknown (protein for MGC: 6737)Mus musculus
503AAH02803843100BC002803 hypothetical proteinHomo sapiens
503AF151072_1843100AF151072 HSPC238Homo sapiens
503BC00555971178RIKEN cDNA 2500002L14 geneMus musculus
504AAH02911856100BC002911 Unknown (protein forHomo sapiens
MGC: 11276)
504AK00323772284unnamed protein productMus musculus
504BC03173272284DNA segment, Chr 7, Wayne StateMus musculus
University 86, expressed
505AAH029452197100BC002945 Similar to hypotheticalHomo sapiens
protein FLJ10101
505AAH210951290100BC021095 Unknown (protein forHomo sapiens
MGC: 31800)
505AK0275861290100unnamed protein productHomo sapiens
506AAH029542552100BC002954 UDP-glucoseHomo sapiens
pyrophosphorylase 2
506BC023810252498UDP-glucose pyrophosphorylase 2Mus musculus
506U27460254299uridine diphosphoglucoseHomo sapiens
pyrophosphorylase
507AAH03005886100BC003005 unactive progesteroneHomo sapiens
receptor, 23 kD
507BC00370887698telomerase binding protein, p23Mus musculus
507L24804886100p23Homo sapiens
508AAH030562132100BC003056 HSPC028 proteinHomo sapiens
508AAH084532132100BC008453 HSPC028 proteinHomo sapiens
508AAH095972132100BC009597 HSPC028 proteinHomo sapiens
510AAH01773591100BC001773 Similar to ribosomalHomo sapiens
protein L34
510AB061832591100ribosomal protein L34Homo sapiens
510BC02851758799Unknown (protein for MGC: 41239)Mus musculus
511AAH01882533100BC001882 Similar to ribosomalHomo sapiens
protein L5
511D10737512100ribosomal protein L5Gallus
gallus
511X57016512100ribosomal protein L5Gallus
gallus
512AAH01884589100BC001884 NADH dehydrogenaseHomo sapiens
(ubiquinone) Fe-S protein 5
(15 kD) (NADH-coenzyme Q
reductase)
512AF020352589100NADH: ubiquinone oxidoreductase 15 kDaHomo sapiens
IP subunit
512AF047434589100NADH-ubiquinone oxidoreductaseHomo sapiens
15 kDa subunit; CI-15 protein
513AAH019262197100BC001926 creatine kinase,Homo sapiens
mitochondrial 1 (ubiquitous)
513AAH064672197100BC006467 creatine kinase,Homo sapiens
mitochondrial 1 (ubiquitous)
513J044692197100creatine kinaseHomo sapiens
514AAH03373763100BC003373 prefoldin 5Homo sapiens
514AB055803763100MM-1 alphaHomo sapiens
514D89667763100c-myc binding proteinHomo sapiens
515AAH05939998100BC005939 prostaglandin D2Homo sapiens
synthase (21 kD, brain)
515AY026356998100prostaglandin D synthaseHomo sapiens
515M98539998100prostaglandin D2 synthaseHomo sapiens
516AAH000451388100BC000045 TONDUHomo sapiens
516AAH033621388100BC003362 TONDUHomo sapiens
516Z976321388100dJ196E23.1.1 (novel protein)Homo sapiens
(isoform 1)
517AAH03366796100BC003366 calcium-regulated heat-Homo sapiens
stable protein (24 kD)
517AF115345_178799AF115345 calcium-regulated heatHomo sapiens
stable protein CRHSP-24
517AF115346_178597AF115346 calcium-regulated heatRattus sp.
stable protein CRHSP-24
518AAH03369581100BC003369 ribosomal protein,Homo sapiens
large, P1
518AAH07590581100BC007590 ribosomal protein,Homo sapiens
large, P1
518AB061836581100ribosomal protein P1Homo sapiens
519AAH03377550100BC003377 Similar to thioredoxinHomo sapiens
519AF313911_1550100AF313911 thioredoxinHomo sapiens
519AY004872550100thioredoxinHomo sapiens
520BC0324931086100cysteine and glycine-rich protein 1Homo sapiens
520M331461086100cysteine-rich proteinHomo sapiens
520M763781086100cysteine-rich proteinHomo sapiens
521AAH033822620100BC003382 sorting nexin 2Homo sapiens
521AF065482261299sorting nexin 2Homo sapiens
521AK075929256498unnamed protein productMus musculus
522AAH033941485100BC003394 heterogeneous nuclearHomo sapiens
ribonucleoprotein C (C1/C2)
522AAH08364147899BC008364 heterogeneous nuclearHomo sapiens
ribonucleoprotein C (C1/C2)
522AAH08423146195BC008423 heterogeneous nuclearHomo sapiens
ribonucleoprotein C (C1/C2)
523AAH035012155100BC003501 Similar to RIKEN cDNAHomo sapiens
2310001A20 gene
523AB0337672155100brain-selective and closelyHomo sapiens
mapped on the counter allele of
CMAP in cystatin cluster
523AL0356612155100dJ568C11.2 (chromosome 20 openHomo sapiens
reading frame 3)
524AAH035123204100BC003512 mesothelinHomo sapiens
524AE006464_21318999AE006464 pre-pro-megakarycyteHomo sapiens
potentiating factor precursor
524D49441319299pre-pro-megakaryocyteHomo sapiens
potentiating factor
525AAH030775288100BC003077 Similar to ATPase, Na+K+Homo sapiens
transporting, alpha 1 polypeptide
525D000995288100Na, K-ATPase alpha-subunitHomo sapiens
525X042975288100ATPase alpha subunit (aa 1-1023)Homo sapiens
526AAH03079786100BC003079 16.7 Kd proteinHomo sapiens
526AAH15639786100BC015639 16.7 Kd proteinHomo sapiens
526AF07884578610016.7 Kd proteinHomo sapiens
527AAH001611827100BC000161 secretory carrierHomo sapiens
membrane protein 3
527AAH051351827100BC005135 secretory carrierHomo sapiens
membrane protein 3
527AF005039181799secretory carrier membraneHomo sapiens
protein
528AAH08704887100BC008704 cytochrome c oxidaseHomo sapiens
subunit IV
528AAH21236887100BC021236 cytochrome c oxidaseHomo sapiens
subunit IV isoform 1
528X54802887100cytochrome-c oxidase subunit IVHomo sapiens
529AAH009151731100BC000915 PDZ and LIM domain 1Homo sapiens
(elfin)
529AAH187551731100BC018755 PDZ and LIM domain 1Homo sapiens
(elfin)
529AJ3105491731100CLP-36 proteinHomo sapiens
530AF236636130298uridine-cytidine kinase 2Mus musculus
530AF2366371333100uridine-cytidine kinase 2Homo sapiens
530BC023789130298uridine-cytidine kinase 2Mus musculus
531AAH00176940100BC000176 RAP1B, member of RASHomo sapiens
oncogene family
531AF493913_1940100AF493913 Ras family small GTPHomo sapiens
binding protein RAP1B
531BC03338295287RAP1B, member of RAS oncogeneMus musculus
family
532D63519870100leptinHomo sapiens
532D63710870100ob proteinHomo sapiens
532U43653870100obese proteinHomo sapiens
533BC002088637100ribosomal protein S25Mus musculus
533BC027208637100ribosomal protein S25Mus musculus
533X62482637100ribosomal protein S25Rattus
Rattus
534AAH036622092100BC003662 KIAA0111 gene productHomo sapiens
534AAH043862092100BC004386 KIAA0111 gene productHomo sapiens
534AAH111512092100BC011151 Similar to KIAA0111 geneHomo sapiens
product
535AF349038_11780100AF349038 TFIID subunit TAFII55Homo sapiens
535BC0327371780100similar to TAF7 RNA polymeraseHomo sapiens
II, TATA box binding protein
(TBP)-associated factor, 55 kD
535X979991780100transcription factor IIDHomo sapiens
536AAH026011673100BC002601 nuclear factor of kappaHomo sapiens
light polypeptide gene enhancer
in B-cells inhibitor, alpha
536AAH049831673100BC004983 nuclear factor of kappaHomo sapiens
light polypeptide gene enhancer
in B-cells inhibitor, alpha
536AY0336001673100NFKBIAHomo sapiens
537AF211480_12102100AF211480 CD001Homo sapiens
537AK0021022086100unnamed protein productHomo sapiens
537AX1915052086100unnamed protein productHomo sapiens
538AAH051104609100BC005110 Unknown (protein forHomo sapiens
MGC: 13217)
538AK049371447393unnamed protein productMus musculus
538AY0448654609100sorting nexin 14Homo sapiens
539AAH05118592100BC005118 Similar to putativeHomo sapiens
translation initiation factor
539AAH08710592100BC008710 putative translationHomo sapiens
initiation factor
539AF083441_1592100AF083441 SUI1 isologHomo sapiens
540AAH051272190100BC005127 adipose differentiation-Homo sapiens
related protein
540AF443203_12190100AF443203 adipose differentiation-Homo sapiens
related protein
540AX025098218199unnamed protein productHomo sapiens
541AAH05143964100BC005143 vitamin A responsive;Homo sapiens
cytoskeleton related
541AAH20797964100BC020797 vitamin A responsive;Homo sapiens
cytoskeleton related
541AY102608964100JWA proteinHomo sapiens
542AAH05228360100BC005228 Unknown (protein forHomo sapiens
MGC: 12250)
543AF0725062871100envelope protein precursorHomo sapiens
543AF208161286899syncytin precursorHomo sapiens
543AF513360_1286899AF513360 enverinHomo sapiens
544AAH053221866100BC005322 decorinHomo sapiens
544AF1383001866100decorin variant AHomo sapiens
544AF491944_11866100AF491944 decorinHomo sapiens
545AAH01392827100BC001392 ribosomal protein S27aHomo sapiens
545D83209827100ubiquitin extention proteinCavia
porcellus
545M24507827100ubiquitinsynthetic
construct
546AAH053301306100BC005330 tissue factor pathwayHomo sapiens
inhibitor 2
546AF2175421306100tissue factor pathway inhibitor 2Homo sapiens
546D299921306100placental protein 5 (PP5)Homo sapiens
547AAH053611334100BC005361 proteasome (prosome,Homo sapiens
macropain) subunit, alpha type, 4
547BC0224451334100proteasome (prosome, macropain)Homo sapiens
subunit, alpha type, 4
547D007631334100proteasome subunit C9Homo sapiens
548AAH053661298100BC005366 ATP synthase, H+Homo sapiens
transporting, mitochondrial F0
complex, subunit b, isoform 1
548AAH163501298100BC016350 Unknown (protein forHomo sapiens
MGC: 24431)
548AL3901951298100bA552M11.3 (ATP synthase, H+Homo sapiens
transporting, mitochondrial F0
complex, subunit b, isoform 1)
549AAH053901993100BC005390 Unknown (protein forHomo sapiens
MGC: 12520)
549AF006305199310026S proteasome regulatory subunitHomo sapiens
549U363951993100conserved ATPase domain proteinSpermophilus
44tridecemlineatus
550AAH10370180099BC010370 Putative prostate cancerHomo sapiens
tumor suppressor
550U42349182610039 kDa encoded by N33Homo sapiens
550U42360180899N33 protein form 1Homo sapiens
551AAH058391492100BC005839 follistatin-like 3Homo sapiens
(secreted glycoprotein)
551BC0331191492100follistatin-like 3 (secretedHomo sapiens
glycoprotein)
551U767021492100follistatin-related protein FLRGHomo sapiens
552AAH05354564100BC005354 ribosomal protein, largeHomo sapiens
P2
552AAH05920564100BC005920 ribosomal protein, largeHomo sapiens
P2
552AAH07573564100BC007573 ribosomal protein, largeHomo sapiens
P2
553AAH17660414100BC017660 Unknown (protein forHomo sapiens
MGC: 14608)
553AJ249731414100putative G8.2 proteinHomo sapiens
553AJ24973230779G8 proteinHomo sapiens
554AAH05966647100BC005966 ring finger protein 7Homo sapiens
554AAH08627647100BC008627 ring finger protein 7Homo sapiens
554AF092878_1647100AF092878 zinc RING finger proteinHomo sapiens
SAG
555AAH059751163100BC005975 calcyclin bindingHomo sapiens
protein
555AF314752_11163100AF314752 calcyclin bindingHomo sapiens
protein
555BC0223521163100Siah-interacting proteinHomo sapiens
556AAH06337739100BC006337 Unknown (protein forHomo sapiens
MGC: 12798)
556M37194739100clathrin-associated protein 17Rattus
norvegicus
556X9707472998clathrin-associated proteinHomo sapiens
557AAH019283365100BC001928 protein disulfideHomo sapiens
isomerase related protein
(calcium-binding protein,
intestinal-related)
557AAH063443365100BC006344 protein disulfideHomo sapiens
isomerase related protein
(calcium-binding protein,
intestinal-related)
557AAH117543365100BC011754 Similar to proteinHomo sapiens
disulfide isomerase related
protein (calcium-binding protein,
intestinal-related)
558AF453478_11155100AF453478 phosphopantetheineHomo sapiens
adenylyltransferase/
dephosphocoenzyme A kinase
558AY0946021155100bifunctional phosphopantetheineHomo sapiens
adenylyl transferase/dephospho
CoA kinase
558BC0209851155100Unknown (protein for MGC: 9724)Homo sapiens
559AAH063932797100BC006393 Similar toHomo sapiens
carboxypeptidase Z
559AF017638241986carboxypeptidase ZRattus
norvegicus
559U83411278799carboxypeptidase Z precursorHomo sapiens
560AF126110_13913100AF126110 fibulin-1 isoform DHomo sapiens
precursor
560U012443913100fibulin-1DHomo sapiens
560X70854339284BM-90/fibulinMus musculus
561AAH023432494100BC002343 Similar to nucleolinHomo sapiens
561AAH064942494100BC006494 Unknown (protein forHomo sapiens
MGC: 1440)
561AAH065162494100BC006516 Unknown (protein forHomo sapiens
MGC: 3588)
562AAH20515772100BC020515 ribosomal protein S14Homo sapiens
562M11241772100ribosomal protein S14Cricetulus
griseus
562M35008772100ribosomal protein S14Cricetulus
griseus
563AAH08926645100BC008926 ribosomal protein L29Homo sapiens
563U10248645100ribosomal protein L29Homo sapiens
563U49083645100HIPHomo sapiens
564AAH067911105100BC006791 ribosomal protein L10aHomo sapiens
564AAH113661105100BC011366 Similar to ribosomalHomo sapiens
protein L10a
564X933521105100ribosomal protein L10aRattus
norvegicus
565AAH014181132100BC001418 Similar to RIKEN cDNAHomo sapiens
1810017F10 gene
565AAH139531132100BC013953 Unknown (protein forHomo sapiens
MGC: 2853)
565AY0275431132100beta-casein-like proteinHomo sapiens
566AAH070381762100BC007038 lumicanHomo sapiens
566BC0359971762100lumicanHomo sapiens
566U211281762100lumicanHomo sapiens
567AAH036091441100BC003609 thioredoxin peroxidaseHomo sapiens
(antioxidant enzyme)
567AAH071071441100BC007107 thioredoxin peroxidaseHomo sapiens
(antioxidant enzyme)
567AAH167701441100BC016770 thioredoxin peroxidaseHomo sapiens
(antioxidant enzyme)
568AAH07282952100BC007282 Unknown (protein forHomo sapiens
MGC: 15626)
568AK01433890997unnamed protein productMus musculus
568M8375193798arginine-rich proteinHomo sapiens
569AAH074021005100BC007402 apolipoprotein DHomo sapiens
569J026111005100apolipoprotein D precursorHomo sapiens
569M166961005100apolipoprotein D precursorHomo sapiens
570AAH01603849100BC001603 Similar to ribosomalHomo sapiens
protein L21
570AAH07505849100BC007505 Unknown (protein forHomo sapiens
MGC: 4136)
570X89401849100ribosomal protein L21Homo sapiens
571AAH07507605100BC007507 ribosomal protein S20Homo sapiens
571BC011323605100Similar to ribosomal protein S20Mus musculus
571X51537605100ribosomal protein S20 (AA 1-119)Rattus
Rattus
572AAH14459791100BC014459 Similar to ribosomalHomo sapiens
protein L23a
572BC029892791100ribosomal protein L23aMus musculus
572X65228791100ribosomal protein L23aRattus
Rattus
573AJ420896211499SPPL2a proteinHomo sapiens
573AK0274462126100unnamed protein productHomo sapiens
573BC025740211499Similar to hypothetical proteinHomo sapiens
FLJ14540
574AF03654855482RGC-32Rattus
norvegicus
574AF036549_1569100AF036549 RGC32Homo sapiens
574AL35483360791bA157L14.2 (RGC32, a novel geneHomo sapiens
induced by complement activation
in oligodendrocytes)
575AAH01024274999BC001024 putative nucleotideHomo sapiens
binding protein, estradiol-
induced
575AK0275142756100unnamed protein productHomo sapiens
575AK027516275399unnamed protein productHomo sapiens
576AAH07834563100BC007834 Unknown (protein forHomo sapiens
MGC: 14141)
577AAH03061233899BC003061 protease, cysteine, 1Homo sapiens
(legumain)
577D55696233599cysteine proteaseHomo sapiens
577Y098622339100legumainHomo sapiens
578AAH080811095100BC008081 Similar to KDEL (Lys-Homo sapiens
Asp-Glu-Leu) endoplasmic
reticulum protein retention
receptor 2
578AAH145681095100BC014568 Similar to KDEL (Lys-Homo sapiens
Asp-Glu-Leu) endoplasmic
reticulum protein retention
receptor 2
578X637451095100KDEL receptorHomo sapiens
579AF004877757499pro-alpha 2(I) collagenHomo sapiens
579J03464755499pre-pro-alpha-2 type I collagenHomo sapiens
579Z746167596100prepro-alpha2(I) collagenHomo sapiens
580AAH08188946100BC008188 Unknown (protein forHomo sapiens
MGC: 5243)
580AF021819946100RNA-binding protein regulatoryHomo sapiens
subunit
580AL034417946100bK215D11.1 (RNA-binding proteinHomo sapiens
regulatory subunit)
581AAH08283594100BC008283 cholecystokininHomo sapiens
581L00354594100cholecystokininHomo sapiens
581M6045856995cholecystokininMacaca
fascicularis
582AAH0679469399BC006794 Similar to interferonHomo sapiens
induced transmembrane protein 3
(1-8U)
582AAH08417698100BC008417 Similar to interferonHomo sapiens
induced transmembrane protein 3
(1-8U)
582BC022439698100interferon induced transmembraneHomo sapiens
protein 3 (1-8U)
583AAH059931421100BC005993 Unknown (protein forHomo sapiens
MGC: 14796)
583AAH086911421100BC008691 Unknown (protein forHomo sapiens
MGC: 8886)
583AAH156441421100BC015644 Ras suppressor protein 1Homo sapiens
584AAH089381942100BC008938 Similar toHomo sapiens
histocompatibility 13
584AAH089591942100BC008959 Similar toHomo sapiens
histocompatibility 13
584AF483215_1193499AF483215 minor histocompatibilityHomo sapiens
antigen H13 isoform 1
585AAH163202150100BC016320 cathepsin D (lysosomalHomo sapiens
aspartyl protease)
585M112332150100preprocathepsin DHomo sapiens
585X053442150100precursor polypeptide (AA −20 toHomo sapiens
392)
586AAH089831364100BC008983 complement component 1,Homo sapiens
q subcomponent, beta polypeptide
586X030841240100C1q B-chain precursorHomo sapiens
586X16874107579precursor polypeptide (AA −25 toMus musculus
228)
587AAH091771014100BC009177 ras homolog gene family,Homo sapiens
member C
587AF498972_11014100AF498972 small GTP bindingHomo sapiens
protein RhoC
587BC0046271014100ras homolog gene family, member CMus musculus
588AAH092001068100BC009200 Rho GDP dissociationHomo sapiens
inhibitor (GDI) beta
588AF498927_11068100AF498927 Rho GDP dissociationHomo sapiens
inhibitor beta
588X695491068100Human rho GDP-dissociationHomo sapiens
Inhibitor 2(IEF 8120)
589AAH092011137100BC009201 clathrin, lightHomo sapiens
polypeptide (Lca)
589AAH192871137100BC019287 clathrin, lightHomo sapiens
polypeptide (Lca)
589AL1588301137100bA421H8.4.2 (clathrin, lightHomo sapiens
polypeptide (LCA))
590AAH09232596100BC009232 Similar to G antigen 8Homo sapiens
590AJ318880596100XAGE-2 proteinHomo sapiens
590AJ318891596100XAGE-2 proteinHomo sapiens
591AAH033781149100BC003378 high-mobility groupHomo sapiens
(nonhistone chromosomal) protein 1
591BC0309811149100high-mobility group (nonhistoneHomo sapiens
chromosomal) protein 1
591X125971149100HMG-1 protein (AA 1-215)Homo sapiens
592AB0023685586100KIAA0370Homo sapiens
592AY0263885765100ran binding protein RanBP20Homo sapiens
592AY029528566397RANBP20Mus musculus
593AAH097991308100BC009799 amphiregulinHomo sapiens
(schwannoma-derived growth
factor)
593M307031308100amphiregulinHomo sapiens
593M307041308100amphiregulinHomo sapiens
594AAH09869511100BC009869 Unknown (protein forHomo sapiens
MGC: 16406)
594AAH15491511100BC015491 Unknown (protein forHomo sapiens
MGC: 8965)
594BC022326511100Unknown (protein for MGC: 22741)Homo sapiens
595AAH098981921100BC009898 spermine synthaseHomo sapiens
595AD0015281921100spermidine aminopropyltransferaseHomo sapiens
595Z490991916100spermine synthaseHomo sapiens
596AL3654101055100hypothetical proteinHomo sapiens
596L3216229470transcription factorHomo sapiens
597AAH100161542100BC010016 Similar to CD47 antigenHomo sapiens
(Rh-related antigen, integrin-
associated signal transducer)
597AAH128841542100BC012884 Unknown (protein forHomo sapiens
MGC: 9240)
597Z255211542100integrin associated proteinHomo sapiens
598AAH10055784100BC010055 hypothetical proteinHomo sapiens
PRO2605
598AF116721_109642100AF116709 PRO2605Homo sapiens
599AAH04976634100BC004976 Unknown (protein forHomo sapiens
IMAGE: 2958115)
599AAH10076634100BC010076 Unknown (protein forHomo sapiens
MGC: 19576)
599AY061855634100mitochondrial ribosomal proteinHomo sapiens
S6
600AAH10129907100BC010129 Similar to hypotheticalHomo sapiens
protein R33729_1
600AAH14655907100BC014655 Unknown (protein forHomo sapiens
MGC: 20383)
600AL365374894100R33729_1 hypothetical proteinHomo sapiens
601AB028894824100ribosomal protein S11Mus musculus
601BC012641824100ribosomal protein S11Mus musculus
601U93864824100ribosomal protein S11Mus musculus
602BC0020771058100RAB1, member RAS oncogene familyMus musculus
602X157441058100GTP-binding proteinMus musculus
602Y000941058100Ypt1 protein (AA 1-205)Mus musculus
603AAH029471482100BC002947 folate receptor 1Homo sapiens
(adult)
603U203911482100folate receptorHomo sapiens
603X627531482100adult folate binding proteinHomo sapiens
604U659323016100extracellular matrix protein 1Homo sapiens
604U659383016100extracellular matrix protein 1Homo sapiens
604U681863016100extracellular matrix protein 1Homo sapiens
605AAH10897541100BC010897 Similar to JM27 proteinHomo sapiens
605AF275258_1541100AF275258 PAGE-4Homo sapiens
605AJ005894541100JM27Homo sapiens
606AAH111712528100BC011171 serine (or cysteine)Homo sapiens
proteinase inhibitor, clade G (C1
inhibitor), member 1
606AF435921_1252499AF435921 C1 esterase inhibitorHomo sapiens
606X07427252499C1 inhibitorHomo sapiens
607D38112178193cytochrome bHomo sapiens
607U09500178093cytochrome bHomo sapiens
607V00662178593cytochrome BHomo sapiens
608AAH11514696100BC011514 Similar to ribosomalHomo sapiens
protein L32
608K02060696100ribosomal protein L32-3AMus musculus
608X06483696100ribosomal protein L32Rattus
norvegicus
609AAH11786645100BC011786 Unknown (protein forHomo sapiens
MGC: 19839)
609AF318382_1645100AF318382 unknownHomo sapiens
609X078684561001.8 kb mRNA (AA 1-84)Homo sapiens
610AAH117921649100BC011792 Unknown (protein forHomo sapiens
MGC: 19561)
610AAH17408164399BC017408 Unknown (protein forHomo sapiens
MGC: 27221)
610U16660160397peroxisomal enoyl-CoA hydratase-Homo sapiens
like protein
611AAH001592163100BC000159 keratin 17Homo sapiens
611AAH119012163100BC011901 Similar to keratin 17Homo sapiens
611X625712163100keratin related productHomo sapiens
612AAH121323933100BC012132 Similar to DEAD/H (Asp-Homo sapiens
Glu-Ala-Asp/His) box polypeptide 1
612BC010624387297Unknown (protein for MGC: 11570)Mus musculus
612X706493933100member of DEAD box protein familyHomo sapiens
613AF157623_12466100AF157623 HTRA serine proteaseHomo sapiens
613D872582466100serin protease with IGF-bindingHomo sapiens
motif
613Y079212466100novel serine protease, PRSS11Homo sapiens
614AF242550_11030100AF242550 cellular nucleic acidRattus
binding proteinnorvegicus
614AF3898871030100zinc finger protein 9Homo sapiens
614D452541030100Cellular Nucleic Acid BindingRattus
Proteinnorvegicus
615AAH142771191100BC014277 Similar to tissueHomo sapiens
inhibitor of metalloproteinase 3
(Sorsby fundus dystrophy,
pseudoinflammatory)
615U331141191100tissue inhibitor ofHomo sapiens
metalloproteinases-3
615X762271191100tissue inhibitor ofHomo sapiens
metalloproteinases-3
616AAH123841017100BC012384 Similar to programmedHomo sapiens
cell death 6
616AF0356061017100calcium binding proteinHomo sapiens
616U58773_11017100U58773 calcium binding proteinHomo sapiens
617AAH12464755100BC012464 prefoldin 2Homo sapiens
617AF117237_1755100AF117237 prefoldin subunit 2Homo sapiens
617BC02683972996Similar to prefoldin 2Mus musculus
618AAH08230849100BC008230 ribosomal protein L12Homo sapiens
618BC01832184899ribosomal protein L12Mus musculus
618L06505849100ribosomal protein L12Homo sapiens
619AAH126061665100BC012606 Similar to proteasomeHomo sapiens
(prosome, macropain) 26S subunit,
non-ATPase, 7 (Mov34 homolog)
619D50063163798proteasome subunit p40/Mov34Homo sapiens
protein
619M6464015979636 kD proteinMus musculus
620AAH1183451485100BC011835 Similar to ATPase,Homo sapiens
Na+/K+ transporting, beta 3
polypeptide
620AF0058961485100Na K-ATPase beta-3 subunitHomo sapiens
620U514781485100sodium/potassium-transportingHomo sapiens
ATPase beta-3 subunit
621AAH130415526100BC013041 Unknown (protein forHomo sapiens
MGC: 4781)
621M580285526100ubiquitin-activating enzyme E1Homo sapiens
621X56976551699ubiquitin activating enzyme E1Homo sapiens
622AAH13162491100BC013162 Similar to heat shockHomo sapiens
protein, 30 kDa
622AF085359491100HSPC030Homo sapiens
622AF537132491100selenoprotein KHomo sapiens
623AAH13175992100BC013175 Similar to novel RGD-Homo sapiens
containing protein
623BC02924995896dynactin 6Mus musculus
623D84145992100WS-3Homo sapiens
624BC0038252344100tubulin, beta 5Mus musculus
624X046632344100beta-tubulin AA 1-444 (79 is 1stMus musculus
base in codon)
624X070112344100c(beta)7 tubulin (AA 1-444)Gallus
gallus
625A47413333696CALPASTATINE HUMAINEHomo sapiens
625AAH135793420100BC013579 Similar to calpastatinHomo sapiens
625D16217334093calpastatinHomo sapiens
626BC024378567100defender against cell death 1Mus musculus
626Y13335567100DAD-1Mus musculus
626Y13336567100DAD-1Rattus
norvegicus
627AAH139753963100BC013975 Similar to sema domain,Homo sapiens
immunoglobulin domain (Ig), short
basic domain, secreted,
(semaphorin) 3B
627BC0242203963100Unknown (protein for MGC: 1483)Homo sapiens
627U28369395199semaphorin VHomo sapiens
628AAH141423503100BC014142 Similar toHomo sapiens
glucuronidase, beta
628AX147652349699unnamed protein productHomo sapiens
628M15182349699beta-glucuronidase precursor (ECHomo sapiens
3.2.1.31)
629AB022163202492mouse ortholog of the zebrafishMus musculus
hagoromo gene
629AF2818592217100dactylinHomo sapiens
629BC027031202492f-box and WD-40 domain protein 4Mus musculus
630AAH013771114100BC001377 DKFZP586G1722 proteinHomo sapiens
630AAH065141114100BC006514 DKFZP586G1722 proteinHomo sapiens
630AAH143911114100BC014391 DKFZP586G1722 proteinHomo sapiens
631AF159256_11147100AF159256 Lps/Ran GTPaseMus musculus
631AF306457_11147100AF306457 GTPaseRattus
norvegicus
631BC0148291147100RAN, member RAS oncogene familyMus musculus
632AAH150001347100BC015000 Similar to majorHomo sapiens
histocompatibility complex, class
II, DP beta 1
632M57466130696light chainHomo sapiens
632X01426130196SB-2-beta precursor polypeptideHomo sapiens
(aa −29 to 229)
633AAH150391006100BC015039 microfibrillar-Homo sapiens
associated protein 2
633AL0495691006100dJ37C10.4 (microfibrillar-Homo sapiens
associated protein 2
(microfibril-associated
glycoprotein precursor, MGAP1))
633U197181006100microfibril-associatedHomo sapiens
glycoprotein
634AF117383_1746100AF117383 placental protein 13;Homo sapiens
PP13
634AY055826746100placenta protein 13Homo sapiens
634BC02225751069Similar to placental protein 13-Homo sapiens
like protein
635AAH023872063100BC002387 nucleosome assemblyHomo sapiens
protein 1-like 1
635AAH155992063100BC015599 nucleosome assemblyHomo sapiens
protein 1-like 1
635AL1620682063100hypothetical proteinHomo sapiens
636A03911201799glia-derived neurite-promotingHomo sapiens
factor (GdNPF)
636AAH156632040100BC015663 Similar to serine (orHomo sapiens
cysteine) proteinase inhibitor,
clade E (nexin, plasminogen
activator inhibitor type 1),
member 2
636M17783201699glia-derived nexin precursorHomo sapiens
637AAH024033107100BC002403 lectin, galactoside-Homo sapiens
binding, soluble, 3 binding
protein (galectin 6 binding
protein)
637AAH029983107100BC002998 lectin, galactoside-Homo sapiens
binding, soluble, 3 binding
protein (galectin 6 binding
protein)
637AAH157613107100BC015761 lectin, galactoside-Homo sapiens
binding, soluble, 3 binding
protein
638AAH150322122100BC015032 ribosomal protein L3Homo sapiens
638AAH157672122100BC015767 ribosomal protein L3Homo sapiens
638BC0080032122100ribosomal protein L3Homo sapiens
639AF0526942391100alpha-tubulinMeriones
unguiculatus
639BC0022192391100Similar to tubulin alpha 1Mus musculus
639BC0081172391100tubulin alpha 1Mus musculus
640AK05484016967unnamed protein productHomo sapiens
640AK09796516364unnamed protein productHomo sapiens
640AX40000815058unnamed protein productHomo sapiens
641AAH02449119699BC002449 Similar to CG10641 geneHomo sapiens
product
641AAH04128133199BC004128 Unknown (protein forHomo sapiens
IMAGE: 3940060)
641AK0236741199100unnamed protein productHomo sapiens
642AAH015372971100BC001537 Unknown (protein forHomo sapiens
MGC: 786)
642AB021743296899PR65Mus musculus
642BC006606296899protein phosphatase 2 (formerlyMus musculus
2A), regulatory subunit A (PR
65), alpha isoform
643AAH09642939100BC009642 FXYD domain-containingHomo sapiens
ion transport regulator 5
643AB072911939100dysadherinHomo sapiens
643AF161462_192398AF161462 HSPC113Homo sapiens
644AAH09687869100BC009687 epithelial membraneHomo sapiens
protein 2
644AY057060869100epithelial membrane protein 2Homo sapiens
644U52100869100XMPHomo sapiens
645AB012214672778DNA cytosine 5 methyltransferaseRattus
Rattus
645AF1806826869100DNA (cytosine-5)-Homo sapiens
methyltransferase
645X636928587100DNA (cytosine-5-)-Homo sapiens
methyltransferase
646AAH15961961100BC015961 adrenomedullinHomo sapiens
646D14874961100adrenomedullin precursorHomo sapiens
646S73906961100adrenomedullin; AMHomo sapiens
647AAH15973514100BC015973 S100 calcium-bindingHomo sapiens
protein A10 (annexin II ligand,
calpactin I, light polypeptide
(p11))
647M38591514100cellular ligand of annexin IIHomo sapiens
647M81457514100calpactin I light chainHomo sapiens
648AAH160561137100BC016056 claudin 3Homo sapiens
648AB0007141137100RVP1Homo sapiens
648AF0071891137100claudin 3Homo sapiens
649AAH161421432100BC016142 Similar to RIKEN cDNAHomo sapiens
2310032N20 gene
649AAH207731432100BC020773 Unknown (protein forHomo sapiens
MGC: 22685)
649AX4058241432100unnamed protein productHomo sapiens
650AF315378_1195598AF315378 suppressor ofRattus
profilin/p41 of actin-relatednorvegicus
complex 2/3
650BC039594196499actin related protein 2/3Homo sapiens
complex, subunit 1A, 41 kDa
650Y089991980100Sop2p-like proteinHomo sapiens
651AF492677_1383100AF492677 odd homeobox 1 proteinHomo sapiens
isoform A
651AF492680_1383100AF492680 odd homeobox 1 proteinHomo sapiens
isoform A
651AF492681_1383100AF492681 odd homeobox 1 proteinHomo sapiens
isoform A
652AK0569922163100unnamed protein productHomo sapiens
652AX392121215599unnamed protein productHomo sapiens
652AY033237215599alcohol dehydrogenase 8Homo sapiens
653AAH16748485100BC016748 ribosomal protein L37aHomo sapiens
653X14069485100ribosomal protein L37a (AA 1-92)Rattus
Rattus
653X73331485100ribosomal protein L37aMus musculus
654AAH128073702100BC012807 Unknown (protein forHomo sapiens
MGC: 3483)
654AAH144853702100BC014485 Unknown (protein forHomo sapiens
MGC: 23206)
654AAH167533702100BC016753 Unknown (protein forHomo sapiens
MGC: 1138)
655AAH158341724100BC015834 annexin A2Homo sapiens
655AAH167741724100BC016774 annexin A2Homo sapiens
655AAH211141724100BC021114 annexin A2Homo sapiens
656AAH17343644100BC017343 ribosomal protein L31Homo sapiens
656BC008223644100ribosomal protein L31Mus musculus
656X04809644100ribosomal protein L31 (AA 1-125)Rattus
norvegicus
657AAH173782955100BC017378 hexosaminidase B (betaHomo sapiens
polypeptide)
657AF378118_12955100AF378118 cervical cancer proto-Homo sapiens
oncogene 7
657M232942955100beta-hexosaminidase beta-subunitHomo sapiens
658AAH121681373100BC012168 Similar to proteasomeHomo sapiens
(prosome, macropain) subunit,
beta type, 4
658AAH174511373100BC017451 proteasome (prosome,Homo sapiens
macropain) subunit, beta type, 4
658AAH174861373100BC017486 proteasome (prosome,Homo sapiens
macropain) subunit, beta type, 4
659AAH061242618100BC006124 IMP (inosineHomo sapiens
monophosphate) dehydrogenase 2
659AAH128402618100BC012840 IMP (inosineHomo sapiens
monophosphate) dehydrogenase 2
659AAH155672618100BC015567 IMP (inosineHomo sapiens
monophosphate) dehydrogenase 2
660AAH074571103100BC007457 hypothetical proteinHomo sapiens
660AAH207961103100BC020796 hypothetical proteinHomo sapiens
HSPC177
660AAH211681103100BC021168 hypothetical proteinHomo sapiens
HSPC177
661AAH04904289499BC004904 nuclear RNA exportHomo sapiens
factor 1
661BC028041289499nuclear RNA export factor 1Homo sapiens
661U800732905100tip associating proteinHomo sapiens
662AF064238_1450397AF064238 smoothelin large isoformHomo sapiens
L2
662AY0619714653100smoothelin-B2Homo sapiens
662AY061972453396smoothelin-B3Homo sapiens
663AAH177731214100BC017773 triggering receptorHomo sapiens
expressed on myeloid cells 1
663AF196329_11214100AF196329 triggering receptorHomo sapiens
expressed on monocytes 1
663AF287008_11214100AF287008 triggering receptorHomo sapiens
expressed on monocytes 1
664AAH17891579100BC017891 vesicle-associatedHomo sapiens
membrane protein 5 (myobrevin)
664AF054825579100VAMP5Homo sapiens
664AF077197579100VAMP5-like proteinHomo sapiens
665AAH17931819100BC017931 Similar to RIKEN cDNAHomo sapiens
1110055A02 gene
665AF400652_1819100AF400652 thyroid hormone receptorHomo sapiens
interacting protein 3
665L40410806100thyroid receptor interactorHomo sapiens
666AAH187321606100BC018732 Unknown (protein forHomo sapiens
MGC: 31847)
666AF125533_11606100AF125533 NADH-cytochrome b5Homo sapiens
reductase isoform
666AX0834211606100unnamed protein productHomo sapiens
667AAH024533263100BC002453 heat shock 70 kD proteinHomo sapiens
1A
667AAH093223263100BC009322 heat shock 70 kD proteinHomo sapiens
1A
667AAH187403263100BC018740 heat shock 70 kD proteinHomo sapiens
1A
6681680052_12856100S62076 lysosomal enzyme beta-N-Homo sapiens
acetylhexosaminidase A
668AAH189272856100BC018927 hexosaminidase A (alphaHomo sapiens
polypeptide)
668M164242856100beta-hexosaminidase alpha chainHomo sapiens
669AAH12992211599BC012992 Similar to RNA bindingHomo sapiens
motif, single stranded
interacting protein 1
669AAH12993211599BC012993 Similar to RNA bindingHomo sapiens
motif, single stranded
interacting protein 1
669AAH189512142100BC018951 RNA binding motif,Homo sapiens
single stranded interacting
protein 1
670AAH16346908100BC016346 Unknown (protein forHomo sapiens
MGC: 24392)
670AAH16354908100BC016354 Unknown (protein forHomo sapiens
MGC: 24480)
670AAH18990908100BC018990 Unknown (protein forHomo sapiens
MGC: 20176)
671AAH01206223599BC001206 Unknown (protein forHomo sapiens
MGC: 3208)
671AK025822350599unnamed protein productHomo sapiens
671AL8338653414100hypothetical proteinHomo sapiens
672AAH06772769100BC006772 ribosomal protein S13Homo sapiens
672BC029732769100ribosomal protein S13Homo sapiens
672X53378769100ribosomal protein S13Rattus
Rattus
673J051921982100alpha-actinHomo sapiens
673X06801196899alpha-actin (AA 1-377)Rattus
Rattus
673X13297196899alpha-actin (AA 1-377)Mus musculus
674AAH00260167599BC000260 aldo-keto reductaseHomo sapiens
family 1, member B1 (aldose
reductase)
674AAH10391167599BC010391 aldo-keto reductaseHomo sapiens
family 1, member B1 (aldose
reductase)
674J050171677100aldose reductaseHomo sapiens
675M222462623100aromatase precursor (ECHomo sapiens
1.14.14.1)
675X135892623100aromatase (AA 1-503)Homo sapiens
675Y07508262099aromatase (AA 1-503)Homo sapiens
676M599163466100acid sphingomyelinaseHomo sapiens
676M81780345099acid sphingomyelinaseHomo sapiens
676X63600346199acid sphingomyelinaseHomo sapiens
677AAH219931707100BC021993 guanine nucleotideHomo sapiens
binding protein (G protein), beta
polypeptide 2-like 1
677M241931707100MHC B complex protein 12.3Gallus
gallus
677X753131707100B complex protein mRNA 12-3Mus musculus
678AAH05358642100BC005358 non-histone chromosomeHomo sapiens
protein 2 (S. cerevisiae)-like 1
678AAH19282642100BC019282 non-histone chromosomeHomo sapiens
protein 2 (S. cerevisiae)-like 1
678BC026755642100Similar to sperm specific antigen 1Mus musculus
679AAH192962747100BC019296 chaperonin containingHomo sapiens
TCP1, subunit 7 (eta)
679AF0262922747100chaperonin containing t-complexHomo sapiens
polypeptide 1, eta subunit; CCT-
eta
679BC008255262895chaperonin subunit 7 (eta)Mus musculus
680BC035220387999similar to complement componentHomo sapiens
680M140583885100human complement C1rHomo sapiens
680X04701387999precursor of C1r (AA −17 to 688)Homo sapiens
681J040803789100complement component C1sHomo sapiens
681M187673789100complement subcomponent C1sHomo sapiens
precursor
681X065963789100complement protein C1s precursorHomo sapiens
682AAH031752072100BC003175 N-myc downstreamHomo sapiens
regulated
682AF0041622072100nickel-specific induction proteinHomo sapiens
682D879532072100RTPHomo sapiens
683AF085250759100calmodulinPerca
flavescens
683D83350759100calmodulinAnas
platyrhynchos
683K01945759100calmodulin (cDNA clone 71)Xenopus
laevis
684AAH079112282100BC007911 calreticulinHomo sapiens
684AAH204932282100BC020493 calreticulinHomo sapiens
684AY0475862282100calreticulinHomo sapiens
685AAH16300533100BC016300 S100 calcium-bindingHomo sapiens
protein A4 (calcium protein,
calvasculin, metastasin, murine
placental homolog)
685Z18950533100CAPLHomo sapiens
685Z33457533100mts1Homo sapiens
686AAH01506710100BC001506 CD59 antigen p18-20Homo sapiens
(antigen identified by monoclonal
antibodies 16.3A5, EJ16, EJ30,
EL32 and G344)
686X16447710100precursor polypeptide (AA −25 toHomo sapiens
103)
686X17198710100CD59 antigen precursorHomo sapiens
687AAH06290898100BC006290 chorionic gonadotropin,Homo sapiens
beta polypeptide
687BC022796898100Unknown (protein for MGC: 39080)Homo sapiens
687BC030994898100chorionic gonadotropin, betaHomo sapiens
polypeptide
688J032251674100lipoprotein-associatedHomo sapiens
coagulation inhibitor precursor
688M586501674100lipoprotein associatedHomo sapiens
coagulation inhibitor
688M594991674100lipoprotein-associatedHomo sapiens
coagulation inhibitor
689AAH141671072100BC014167 Unknown (protein forHomo sapiens
MGC: 20892)
689AAH208041072100BC020804 ribosomal protein L13Homo sapiens
689BC0274631072100ribosomal protein L13Homo sapiens
690AAH211361333100BC021136 Unknown (protein forHomo sapiens
MGC: 32056)
690AF097362_11333100AF097362 gamma-interferonHomo sapiens
inducible lysosomal thiol
reductase
690BC031020132999interferon, gamma-inducibleHomo sapiens
protein 30
691AAH07008929100BC007008 crystallin, alpha BHomo sapiens
691M28638929100alpha-B2-crystallinHomo sapiens
691S45630929100alpha B-crystallinHomo sapiens
692BC003775116999casein kinase II, beta subunitMus musculus
692M304481174100casein kinase II beta subunitHomo sapiens
692M59458116999casein kinase II beta subunitGallus
gallus
693M77820620950fibronectinXenopus
laevis
693X027611257099fibronectin precursorHomo sapiens
693X15906730565precursor polypeptide (AA −32 toRattus
2445)norvegicus
694BC032329274099cytochrome P450, subfamily XIAHomo sapiens
(cholesterol side chain cleavage)
694M145652753100cholesterol side-chain cleavageHomo sapiens
enzyme P450scc (EC 1.14.15.67)
694X05367273499desmolaseHomo sapiens
695AF318372_159299AF318372 unknownHomo sapiens
695AJ318881601100XAGE-3 proteinHomo sapiens
695AJ318893601100XAGE-3 proteinHomo sapiens
696AAH186412406100BC018641 eukaryotic translationHomo sapiens
elongation factor 1 alpha 1
696AAH216862406100BC021686 eukaryotic translationHomo sapiens
elongation factor 1 alpha 1
696BC0286742406100eukaryotic translation elongationHomo sapiens
factor 1 alpha 1
697AAH070442377100BC007044 fibrinogen, gammaHomo sapiens
polypeptide
697AAH216742377100BC021674 fibrinogen, gammaHomo sapiens
polypeptide
697AF350254_12377100AF350254 fibrinogen gamma chain,Homo sapiens
isoform gamma-A precursor
698AAH077852357100BC007785 Unknown (protein forHomo sapiens
IMAGE: 2819608)
698AAH215652387100BC021565 Unknown (protein forHomo sapiens
MGC: 31904)
698AF121858_12387100AF121858 sorting nexin 8Homo sapiens
699AAH059291222100BC005929 proteoglycan 2, boneHomo sapiens
marrow (natural killer cell
activator, eosinophil granule
major basic protein)
699X140881222100major basic protein precusor (AAHomo sapiens
1-222)
699Y008091222100major basic preproprotein (AA −15Homo sapiens
to 207)
700AL050169951100hypothetical proteinHomo sapiens
700M34046951100placental protein 14 precursorHomo sapiens
(PP14)
700M61886951100pregnancy-associated endometrialHomo sapiens
alpha2-globulin
701AAH156412224100BC015641 enolase 1, (alpha)Homo sapiens
701BC0225452224100enolase 1, (alpha)Homo sapiens
701BC0277252224100enolase 1, (alpha)Homo sapiens
702AF2721422649100cytochrome P450Homo sapiens
702BC0325942649100cytochrome P450, subfamily IIJHomo sapiens
(arachidonic acid epoxygenase)
polypeptide 2
702U371432649100cytochrome P450 monooxygenaseHomo sapiens
CYP2J2
703AAH171231367100BC017123 ribosomal protein S3AHomo sapiens
703AAH190721367100BC019072 ribosomal protein S3AHomo sapiens
703BC0301611367100ribosomal protein S3AHomo sapiens
704AB042200200488low-density lipoprotein receptor-Mus musculus
related protein 9
704AL834518215499hypothetical proteinHomo sapiens
704AX359701226899unnamed protein productHomo sapiens
705BC040431510499glucosidase, alpha; acid (PompeHomo sapiens
disease, glycogen storage disease
type II)
705M344245105100acid alpha-glucosidaseHomo sapiens
705X550805105100acid alpha-glucosidaseHomo sapiens
706AAH10914768100BC010914 Similar to hemoglobin,Homo sapiens
gamma G
706BC029387768100hemoglobin, gamma GHomo sapiens
706M91037768100G-gamma globinHomo sapiens
707AY1481004568100colony stimulating factor 3Homo sapiens
receptor (granulocyte)
707M598184568100granulocyte colony-stimulatingHomo sapiens
factor receptor
707X557214568100granulocyte colony stimulatingHomo sapiens
factor receptor 25-1
708AAH000131579100BC000013 insulin-like growthHomo sapiens
factor binding protein 3
708AAH189621579100BC018962 insulin-like growthHomo sapiens
factor binding protein 3
708M358781579100growth factor-binding protein-3Homo sapiens
precursor
709M235951413100insulin-like growth factorHomo sapiens
binding protein 1
709M593161413100insulin-like growth factorHomo sapiens
binding protein-1
709X123851413100PP12 precorsor (AA −25 to 234)Homo sapiens
710BC041218676100H3 histone, family 3BXenopus
laevis
710M11393676100histone 3.3Gallus
gallus
710Y00392676100histone H3.3B (AA 1-136)Gallus
gallus
711AF523281191699MHC class Ib antigenHomo sapiens
711AF523283191699MHC class Ib antigenHomo sapiens
711M200221922100HLA-E class I protein precursorHomo sapiens
712AAH035691980100BC003569 E74-like factor 3 (etsHomo sapiens
domain transcription factor,
epithelial-specific)
712AF0173071980100Ets-related transcription factorHomo sapiens
712AF110184_11980100AF110184 epithelium-restrictedHomo sapiens
Ets protein ESX
713AF5233051810100MHC class Ib antigenHomo sapiens
713AF5233061810100MHC class Ib antigenHomo sapiens
713AF5233091810100MHC class Ib antigenHomo sapiens
714AAH0950783699BC009507 Unknown (protein forHomo sapiens
MGC: 3945)
714AY16864883699ubiquitin-like protein ISG15Homo sapiens
714M1375583910017-kDa proteinHomo sapiens
715AB033054254995KIAA1228 proteinHomo sapiens
715AF099138135151GLUT4 vesicle proteinRattus
norvegicus
715BC011482135850Similar to membrane bound C2Mus musculus
domain containing protein
716AAH108531129100BC010853 Similar to integral typeHomo sapiens
I protein
716AAH174951129100BC017495 integral type I proteinHomo sapiens
716BC0222321129100integral type I proteinHomo sapiens
717AF357203_1183297AF357203 MAP kinase phosphatase-1Rattus
norvegicus
717BC0224631886100dual specificity phosphatase 1Homo sapiens
717X682771886100protein-tyrosine phosphataseHomo sapiens
718AAH09407687100BC009407 ribosomal protein S17Homo sapiens
718AAH19899687100BC019899 ribosomal protein S17Homo sapiens
718BC022370687100ribosomal protein S17Homo sapiens
719AAH151051370100BC015105 proteasome (prosome,Homo sapiens
macropain) subunit, alpha type, 1
719AAH153561370100BC015356 proteasome (prosome,Homo sapiens
macropain) subunit, alpha type, 1
719BC0223721370100proteasome (prosome, macropain)Homo sapiens
subunit, alpha type, 1
720AAH03352723100BC003352 tumor protein,Homo sapiens
translationally-controlled 1
720BC022436723100Similar to tumor protein,Homo sapiens
translationally-controlled 1
720X16064723100tumor protein (AA 1-172)Homo sapiens
721BC0230063271100Unknown (protein for MGC: 30059)Homo sapiens
721M270243271100heat shock proteinHomo sapiens
721X15183327110090 kDa heat-shock protein (AA 1-732)Homo sapiens
722AAH080642806100BC008064 monoamine oxidase AHomo sapiens
722M688572806100monoamine oxidase AHomo sapiens
722M692262806100monoamine oxidase AHomo sapiens
723M843781952100lymphocyte antigenHomo sapiens
723M84379194599MHC class I lymphocyte antigenHomo sapiens
723Z27120194699HLA-A2 SLUHomo sapiens
724BC0323501338100major histocompatibility complex,Homo sapiens
class II, DR alpha
724M603341338100cell surface glycoproteinHomo sapiens
724Z848141338100dJ172K2.4.1 (majorHomo sapiens
histocompatibility complex, class
II, DR alpha, isoform 1)
725AAH02476803100BC002476 non-metastatic cells 2,Homo sapiens
protein (NM23B) expressed in
725L16785803100c-myc transcription factorHomo sapiens
725X58965803100NM23-H2 proteinHomo sapiens
726AAH116451585100BC011645 Similar to Ras-relatedHomo sapiens
associated with diabetes
726L245641585100RadHomo sapiens
726U46165156599Rad GTPaseHomo sapiens
727AAH033581151100BC003358 ribosomal protein L10Homo sapiens
727BC0262761151100ribosomal protein L10Homo sapiens
727L441401151100QMHomo sapiens
728A845272912100unnamed protein productunidentified
728AX0240422912100fusion between Aequorea victoriasynthetic
and humanconstruct
728M623992912100NF-kappa-B transcription factorHomo sapiens
729AAH108602071100BC010860 serine (or cysteine)Homo sapiens
proteinase inhibitor, clade E
(nexin, plasminogen activator
inhibitor type 1), member 1
729AF386492_12071100AF386492 serine-cysteineHomo sapiens
proteinase inhibitor clade E
member 1
729X044292071100precursor polypeptideHomo sapiens
730AAH004911316100BC000491 proliferating cellHomo sapiens
nuclear antigen
730AF347680_11316100AF347680 proliferating cellMacaca
nuclear antigenfascicularis
730AL1219241316100dJ746J20.2 (proliferating cellHomo sapiens
nuclear antigen)
731AC0071652130100interleukin-1 receptor type IIHomo sapiens
731AY1240102130100interleukin 1 receptor, type IIHomo sapiens
731X597702130100type II interleukin-1 receptorHomo sapiens
732BC0410712366100protein phosphatase 2 (formerlyHomo sapiens
2A), regulatory subunit B (PR
52), alpha isoform
732M649292366100protein phosphatase-2A subunit-Homo sapiens
alpha
732U093562366100protein phosphatase 2A1 B alphaOryctolagus
subunitcuniculus
733M34421227999pregnancy-specific beta-1Homo sapiens
glycoprotein precursor
733M34481227999pregnancy-specific beta-1-Homo sapiens
glycoprotein 11
733M585912291100PSG11Homo sapiens
734BC01825470397retinol binding protein 1,Mus musculus
cellular
734M11433724100retinol-binding proteinHomo sapiens
734X07437724100cellular retinol binding proteinHomo sapiens
735J03149423783M-CSF receptorFelis catus
735U639635158100CSF-1 receptorHomo sapiens
735X03663515099put. c-fms precursorHomo sapiens
736BC005580902100polymerase (RNA) II (DNAMus musculus
directed) polypeptide G
736U52427902100RNA polymerase II seventh subunitHomo sapiens
736Z71925902100RNA polymerase II RPB7 subunit-Rattus
like proteinnorvegicus
737AAH11601658100BC011601 interferon, alpha-Homo sapiens
inducible protein (clone IFI-6-
16)
737AAH15603658100BC015603 interferon, alpha-Homo sapiens
inducible protein (clone IFI-6-
16)
737D1138465298ORFPan
troglodytes
738AF1470831683100gamma-glutamyl hydrolaseHomo sapiens
738BC0250251683100gamma-glutamyl hydrolaseHomo sapiens
(conjugase,
folylpolygammaglutamyl hydrolase)
738U552061683100human gamma-glutamyl hydrolaseHomo sapiens
739AAH104181552100BC010418 laminin receptor 1Homo sapiens
(67 kD, ribosomal protein SA)
739AAH138271552100BC013827 laminin receptor 1Homo sapiens
(67 kD, ribosomal protein SA)
739U43901155210037 kD laminin receptorHomo sapiens
precursor/p40 ribosome associated
protein
740BC0260334101100gelsolin (amyloidosis, FinnishHomo sapiens
type)
740X044124101100plasma gelsolinHomo sapiens
740X13871384994gelsolinSus scrofa
741AF304463_12813100AF304463 calcium transportHomo sapiens
protein CaT1
741AF365927_12813100AF365927 calcium transportHomo sapiens
protein CaT1
741AF365928_12946100AF365928 calcium transportHomo sapiens
protein CaT1
742AY0405422353100sialic acid bindingHomo sapiens
immunoglobulin-like lectin 6
742D863582353100CD33L1Homo sapiens
742U71382224697OB binding protein-1Homo sapiens
743AF286534_11115100AF286534 GTP-binding proteinRattus
RAB11Bnorvegicus
743AF498947_11115100AF498947 small GTP bindingHomo sapiens
protein RAB11B
743X79780111099YPT3Homo sapiens
744BC010604125399ribosomal protein S6Mus musculus
744BC0276201256100ribosomal protein S6Homo sapiens
744Z54209125399rpS6Mus musculus
745AJ005654703100secondary lymphoid tissueHomo sapiens
chemokine
745BC027918703100small inducible cytokineHomo sapiens
subfamily A (Cys—Cys), member 21
745U88320703100beta chemokine Exodus-2Homo sapiens
746AF148856_2661398AF148856 unknownHomo sapiens
746AF149422_2661598AF149422 unknownHomo sapiens
746U935646714100putative p150Homo sapiens
747AK0120131608100unnamed protein productMus musculus
747BC003742160810026S proteasome-associated pad1Mus musculus
homolog
747U86782160810026S proteasome-associated pad1Homo sapiens
homolog
748AK011431484100unnamed protein productMus musculus
748BC041218676100H3 histone, family 3BXenopus
laevis
748Y00392676100histone H3.3B (AA 1-136)Gallus
gallus
749AAH11262271699BC011262 Unknown (protein forHomo sapiens
MGC: 18226)
749AF00604327191003-phosphoglycerate dehydrogenaseHomo sapiens
749AF171237_12719100AF171237 3-phosphoglycerateHomo sapiens
dehydrogenase
750AF109197_11254100AF109197 nuclear chloride channelHomo sapiens
750AJ012008125199RNCC proteinHomo sapiens
750U932051254100nuclear chloride ion channelHomo sapiens
protein
751BC0294021311100proteasome (prosome, macropain)Homo sapiens
subunit, alpha type, 3
751BC038990130799Similar to proteasome (prosome,Homo sapiens
macropain) subunit, alpha type, 3
751D00762130799proteasome subunit C8Homo sapiens
752AB062400671100Similar to ribosomal protein S15aHomo sapiens
752BC030569671100ribosomal protein S15aHomo sapiens
752X77953671100ribosomal protein S15aRattus
norvegicus
753AB0624381926100OK/SW-CL.30Homo sapiens
753BC025832158190Unknown (protein for MGC: 37936)Mus musculus
753BC036872191299Unknown (protein forHomo sapiens
IMAGE: 5225889)
754AAH167062319100BC016706 eukaryotic translationHomo sapiens
initiation factor 3, subunit 6
(48 kD)
754AAH216792319100BC021679 eukaryotic translationHomo sapiens
initiation factor 3, subunit 6
(48 kD)
754BC0291772319100eukaryotic translation initiationMus musculus
factor 3, subunit 6 (48 kD)
755AAH04138146599BC004138 ribosomal protein L6Homo sapiens
755BC0310091475100ribosomal protein L6Homo sapiens
755BC032299146599ribosomal protein L6Homo sapiens
756AAH158132331100BC015813 eukaryotic translationHomo sapiens
elongation factor 1 gamma
756BC0281792331100eukaryotic translation elongationHomo sapiens
factor 1 gamma
756BC0310122331100eukaryotic translation elongationHomo sapiens
factor 1 gamma
757AAH049271051100BC004927 Unknown (protein forHomo sapiens
MGC: 10432)
757AF013711105110022 kDa actin-binding proteinHomo sapiens
757D843421051100SM22 alphaHomo sapiens
758AB00751012543100PRP8 proteinHomo sapiens
758AB0473911246199pre-mRNA processing 8 proteinMus musculus
758AF0925651247799splicing factor Prp8Homo sapiens
759AAH100343127100BC010034 thyroid autoantigen 70 kDHomo sapiens
(Ku antigen)
759AAH121543127100BC012154 Similar to thyroidHomo sapiens
autoantigen 70 kD (Ku antigen)
759AAH182593127100BC018259 thyroid autoantigen 70 kDHomo sapiens
(Ku antigen)
760AL050369249299hypothetical proteinHomo sapiens
760AY0408222500100U4/U6 snRNP-associated 61 kDaHomo sapiens
protein
760BC018376247998Unknown (protein for MGC: 19247)Mus musculus
761AF343440_145498AF343440 lysosomal H+Canis
transporting-ATPase subunit M9.2familiaris
761AX400012459100unnamed protein productHomo sapiens
761Y15286459100vacuolar proton-ATPase subunitHomo sapiens
M9.2
762AAH01273183199BC001273 galactose-4-epimerase,Homo sapiens
UDP-
762AF0223821835100UDP-galactose 4′ epimeraseHomo sapiens
762L416681835100UDP-galactose-4-epimeraseHomo sapiens
763AAH0527090099BC005270 NADH dehydrogenaseHomo sapiens
(ubiquinone) Fe-S protein 4
(18 kD) (NADH-coenzyme Q
reductase)
763AF020351904100NADH: ubiquinone oxidoreductase 18 kDaHomo sapiens
IP subunit
763X6321583990NADH dehydrogenaseBos taurus
764AAH04963674100BC004963 ATP synthase, H+Homo sapiens
transporting, mitochondrial F0
complex, subunit c (subunit 9),
isoform 1
764AL080089674100hypothetical proteinHomo sapiens
764X69907674100P1 gene for c subunit of humanHomo sapiens
mitochondrial ATP synthase
765AF100620_11492100AF100620 transcription factor-Homo sapiens
like protein MRGX
765AF167174_11492100AF167174 MSL3-2 proteinHomo sapiens
765AL0496101492100dJ1055C14.2 (KIAA0026Homo sapiens
(transcription factor-like
protein MRGX))
766AAH15557185499BC015557 Unknown (protein forHomo sapiens
MGC: 1567)
766BC021637114066CD68 antigenMus musculus
766S572351858100CD68Homo sapiens
767L276314010100amyloid precursor-like protein 2Homo sapiens
767S600994010100APPHHomo sapiens
767Z225724010100CDEI binding proteinHomo sapiens
768AAH08850127399BC008850 Unknown (protein forHomo sapiens
MGC: 14308)
768AAH09599127399BC009599 Unknown (protein forHomo sapiens
MGC: 14690)
768L165581276100ribosomal protein L7Homo sapiens
769AF06248284599SDP3Mus musculus
769AF062483852100SDP3Homo sapiens
769AF52042083898sorting nexin 3Mus musculus
770AF0636576995100vascular endothelial growthHomo sapiens
factor receptor
770D28498588282Fit-1 tyrosine kinase receptorRattus
norvegicus
770X51602698999flt gene product (AA 1-1338)Homo sapiens
771AF08111223934ORF2Mus musculus
domesticus
771U8311924434ORF2 consensus sequence encodingRattus
endonuclease and reversenorvegicus
transcriptase minus RNaseH
771U9357233642putative p150Homo sapiens
772AF0297293066100neuralizedHomo sapiens
772BC026336304199neuralized-like (Drosophila)Homo sapiens
772U878643066100neuralized homologHomo sapiens
773AAH20782643100BC020782 glycoprotein hormones,Homo sapiens
alpha polypeptide
773J00152643100glycoprotein alpha subunitHomo sapiens
773V00518643100chorionic gonadotropinHomo sapiens
774AAH027222070100BC002722 guanine nucleotideHomo sapiens
binding protein (G protein),
alpha stimulating activity
polypeptide 1
774AF493897_12070100AF493897 guanine nucleotideHomo sapiens
binding protein alpha s long
774X044082070100alpha-S2 (aa 1-394)Homo sapiens
775BC0337141724100heterogeneous nuclearHomo sapiens
ribonucleoprotein A1
775D867291724100TISMus musculus
775M991671724100RNA binding proteinMus musculus
776AF0728361827100Sox-like transcriptional factorHomo sapiens
776AF146223_1620100AF146223 HMG domain protein HMGX2Homo sapiens
776AF288679620100smarcel-related proteinHomo sapiens
777AAH219791360100BC021979 ribosomal protein L7aHomo sapiens
777BC0325331360100ribosomal protein L7aHomo sapiens
777X150131360100ribosomal protein L7a (AA 1-266)Rattus
Rattus
778X51538693100ribosomal protein S24 (AA 1-133)Rattus
Rattus
778X52445693100ribosomal protein S24Rattus
norvegicus
778X52658693100ribosomal protein S19 (AA 1-133)Mesocricetus
auratus
779AAH015032789100BC001503 prosaposin (variantHomo sapiens
Gaucher disease and variant
metachromatic leukodystrophy)
779AAH042752789100BC004275 prosaposin (variantHomo sapiens
Gaucher disease and variant
metachromatic leukodystrophy)
779AAH076122789100BC007612 prosaposin (variantHomo sapiens
Gaucher disease and variant
metachromatic leukodystrophy)
780AAH117761369100BC011776 Similar to tropomyosin 2Homo sapiens
(beta)
780M748171369100tropomyosin-1Homo sapiens
780M751651369100tropomyosinHomo sapiens
781AL023883117399dJ404K8.1 (prolactin)Homo sapiens
781BC0158501185100similar to prolactin precursorHomo sapiens
781V005661185100reading frame prolactinHomo sapiens
782AK01260124764unnamed protein productMus musculus
782AK02140928669unnamed protein productMus musculus
782AK07580124664unnamed protein productMus musculus
783AF300943_1946894AF300943 tyrosine phosphatase LARMus musculus
783L11586948495leukocyte common antigen-relatedRattus
phosphatasenorvegicus
783Y008159953100put. LAR preprotein (AA −16 toHomo sapiens
1881)
784AAH160462739100BC016046 ATP synthase, H+Homo sapiens
transporting, mitochondrial F1
complex, alpha subunit, isoform
1, cardiac muscle
784AAH193102739100BC019310 ATP synthase, H+Homo sapiens
transporting, mitochondrial F1
complex, alpha subunit, isoform
1, cardiac muscle
784X654602739100ATP synthase alpha subunitHomo sapiens
785AF237581_1613100AF237581 migration inhibitoryHomo sapiens
factor-related protein 14 variant P
785M26311613100cystic fibrosis antigenHomo sapiens
785X06233613100MRP-14 (AA 1-114)Homo sapiens
786AAH1549252396BC015492 Unknown (protein forHomo sapiens
MGC: 8967)
786BC03262628064TLH29 protein precursorHomo sapiens
786X67325556100ISG12Homo sapiens
787L001602135100phosphoglycerate kinaseHomo sapiens
787M119682135100phosphoglycerate kinaseHomo sapiens
787V005722135100coding sequenceHomo sapiens
788AF07557511112100dysferlinHomo sapiens
788AF188290_11035593AF188290 dysferlinMus musculus
788AK074104793998FLJ00175 proteinHomo sapiens
789AB05222910414100RNA polymerase II largest subunitCricetulus
789D8729410414100RNA polymerase II largest subunitCricetulus
griseus
789X6356410414100RNA polymerase II largest subunitHomo sapiens
790AF070650844100F1FO-type ATP synthase subunit dHomo sapiens
790AF087135844100F1FO-type ATPase subunit dHomo sapiens
790BC038092844100ATP synthase, H+ transporting,Homo sapiens
mitochondrial F0 complex, subunit d
791U01153404697GRP94Canis
familiaris
791X151874112100precursor polypeptide (AA −21 toHomo sapiens
782)
791Y09136403897gp96/GRP94Sus scrofa
792AF297036_1670100AF297036 ubiquitin fusion proteinOphiophagus
hannah
792BC014772670100ubiquitin A-52 residue ribosomalMus musculus
protein fusion product 1
792M24508670100ubiquitinsynthetic
construct
793AB04760016767hypothetical proteinMacaca
fascicularis
793AK09708520848unnamed protein productHomo sapiens
793X9248516568pvalPlasmodium
vivax
794AF100956782100ribosomal protein subunit S18Mus musculus
794AF110520782100RPS18Mus musculus
794M76763782100ribosomal proteinMus musculus
795BC025077930100RIKEN cDNA 2010203J19 geneMus musculus
795L05092930100ribosomal protein L11Homo sapiens
795X62146930100ribosomal protein L11Rattus
Rattus
796AB037890679599pre-mRNA splicing factor SF3b 155 kDaMus musculus
subunit
796AF0542846808100spliceosomal protein SAP 155Homo sapiens
796Y08997656696146 kDa nuclear proteinXenopus
laevis
797AF072097624100beta-2 microglobulinHomo sapiens
797AY007153624100similar to Homo sapiens mRNA for
beta 2-microglobulin with GenBank
Accession Number AB021288
797BC032589624100beta 2-microglobulinHomo sapiens
798AAH178391602100BC017839 caspase 4, apoptosis-Homo sapiens
related cysteine protease
798U289761602100Mih1/TX isoform alphaHomo sapiens
798U289771769100Mih1/TX isoform betaHomo sapiens
799AAH07967974100BC007967 Unknown (protein forHomo sapiens
MGC: 14460)
799AAH12149974100BC012149 Unknown (protein forHomo sapiens
MGC: 20365)
799BC031906974100similar to ribosomal protein L9;Homo sapiens
60S ribosomal protein L9
800BC002145745100ribosomal protein S23Mus musculus
800D14530745100ribosomal proteinHomo sapiens
800X77398745100ribosomal protein S23Rattus
norvegicus
801AF227256_1405100AF227256 NEDD8Bos taurus
801BC00462539898neural precursor cell expressed,Mus musculus
developmentally down-regulated
gene 8
801D23662405100ubiquitin-like proteinHomo sapiens
802U46034207683stromelysin 3Rattus
norvegicus
802X577662679100stromelysin-3 precursorHomo sapiens
802Z12604216481stromelysin-3Mus musculus
803AAH01734499100BC001734 protein translocationHomo sapiens
complex beta
803AL137067499100bA13B9.2 (novel protein similarHomo sapiens
to the beta subunit of transport
protein SEC61)
803L25085499100Sec61-complex beta-subunitHomo sapiens
804AF165522_1360100AF165522 ras-related GTP-bindingHomo sapiens
protein 4b
804AF217985_1360100AF217985 unknownHomo sapiens
804AF498935_1360100AF498935 small GTP bindingHomo sapiens
protein RAB4B
805AF006602543694histone deacetylase mHDA1Mus musculus
805AF132608_15784100AF132608 histone deacetylase 5Homo sapiens
805AF207748_1543194AF207748 histone deacetylase 5Mus musculus
806AL0502594009100hypothetical proteinHomo sapiens
806BC0326814009100RAB2, member RAS oncogene family-Homo sapiens
like
806Z971844009100cICF0811.4.1 (RAB2, member RASHomo sapiens
oncogene family-like, isoform 1)
807AF151855_11278100AF151855 CGI-97 proteinHomo sapiens
807AK001779121496unnamed protein productHomo sapiens
807BC003849120094RIKEN cDNA 4733401P19 geneMus musculus
808AAH002341377100BC000234 nicotinamide N-Homo sapiens
methyltransferase
808U080211377100nicotinamide N-methyltransferaseHomo sapiens
808U209711377100nicotinamide N-methyltransferaseHomo sapiens
809AAH031371240100BC003137 ribosomal protein S3Homo sapiens
809BC0341491240100ribosomal protein S3Homo sapiens
809U149921240100ribosomal protein S3Homo sapiens
810AF090891_1391399AF090891 PRO0105Homo sapiens
810AF268075_1391399AF268075 TRAF6-binding proteinHomo sapiens
T6BP
810U338213924100tax1-binding protein TXBP151Homo sapiens
811AF186112_1619100AF186112 neurokinin B-likeHomo sapiens
protein ZNEUROK1
811AF216586_1619100AF216586 neurokinin BHomo sapiens
811BC032145619100tachykinin 3 (neuromedin K,Homo sapiens
neurokinin beta)
812AAH08405204490BC008405 Unknown (protein forHomo sapiens
MGC: 14528)
812M94891204290pregnancy-specific beta-1Homo sapiens
glycoprotein
812U184672252100pregnancy-specific beta 1-Homo sapiens
glycoprotein 7 precursor
813AK00298998093unnamed protein productMus musculus
813D38076104199Ran-BP1 (Ran-binding protein 1)Homo sapiens
813X836171057100RanBP1Homo sapiens
814AF1526043398100bromodomain-containing proteinHomo sapiens
814AF213969336999bromodomain protein CELTIX1Homo sapiens
814AJ2718813398100bromodomain containing proteinHomo sapiens
815AK00049632765unnamed protein productHomo sapiens
815AK09051132865unnamed protein productHomo sapiens
815AX39996331962unnamed protein productHomo sapiens
816AK0009172276100unnamed protein productHomo sapiens
816BC025560215694Similar to hypothetical proteinMus musculus
FLJ10055
816BC039867225999hypothetical protein FLJ10055Homo sapiens
817AB0398861071100down-regulated in gastric cancerHomo sapiens
817AY13918299510018 kDa antrum mucosa proteinHomo sapiens
817AY13918499510018 kDa antrum mucosa proteinHomo sapiens
818BC033721354099Unknown (protein for MGC: 45264)Homo sapiens
818X821573543100hevinHomo sapiens
818X86693350499Hevin-like proteinHomo sapiens
819M84472167510017-beta-hydroxysteroidHomo sapiens
dehydrogenase
819U34879167510017-beta-hydroxysteroidHomo sapiens
dehydrogenase
819X13440167510017-HSD protein (AA 1-328)Homo sapiens
820AAH12612181299BC012612 Similar to cathepsin LHomo sapiens
820M204961816100preprocathepsin L precursorHomo sapiens
820X124511816100pro-(cathepsin L)Homo sapiens
821AAH123553449100BC012355 Similar to soluteHomo sapiens
carrier family 6
(neurotransmitter transporter,
creatine), member 8
821U363413449100creatine transporterHomo sapiens
821Z665393449100creatine transporterHomo sapiens
822AF267852_1749100AF267852 placental protein 13-Homo sapiens
like protein
822AF367430571100placental protein 13-likeHomo sapiens
822BC02225773198Similar to placental protein 13-Homo sapiens
like protein
823AB001636407299ATP-dependent RNA helicase #46Homo sapiens
823AF279891_14162100AF279891 dead box protein 15Homo sapiens
823BC0359744162100DEAD/H (Asp-Glu-Ala-Asp/His) boxHomo sapiens
polypeptide 15
824AAH17321687100BC017321 Unknown (protein forHomo sapiens
MGC: 29768)
824BC002079687100Similar to ribosomal protein S12Mus musculus
824BC018362687100Unknown (protein for MGC: 19264)Mus musculus
825AAH20619112399BC020619 glutathione S-Homo sapiens
transferase A3
825AF508266_11127100AF508266 glutathione transferaseHomo sapiens
A3-3
825AL1219691127100dJ214M20.1 (glutathione S-Homo sapiens
transferase A3)
826AAH00359923100BC000359 signal peptidase complexHomo sapiens
(18 kD)
826AAH14508923100BC014508 Similar to signalHomo sapiens
peptidase complex (18 kD)
826AF061737923100microsomal signal peptidaseHomo sapiens
827AF179890_1598100AF179890 DNA polymerase deltaHomo sapiens
smallest subunit p12
827AF515709_149283AF515709 small subunit DNAMus musculus
polymerase delta p12
827BC02852049283Unknown (protein for MGC: 41275)Mus musculus
828AC005067_2134073AC005067 Supported by Human ESTHomo sapiens
H08032.1 (NID: g872854), mouse EST
AA870042.1 (NID: g2965487), and
genscan
828AF226732_12286100AF226732 NPD007Homo sapiens
828BC018360119968Unknown (protein for MGC: 18730)Mus musculus
829AAH19040897100BC019040 Unknown (protein forHomo sapiens
MGC: 20769)
829D11428826100PMP-22(PAS-II/SR13/Gas-3)Homo sapiens
829L03203826100peripheral myelin protein 22Homo sapiens
830AK023767960100unnamed protein productHomo sapiens
830AL080169979100hypothetical proteinHomo sapiens
830BC016647960100Unknown (protein for MGC: 16844)Homo sapiens
831AF309646_1114488AF309646 Rab6-like protein WTH3Homo sapiens
831AF498941_11058100AF498941 small GTP bindingHomo sapiens
protein RAB6C
831AL136727114488hypothetical proteinHomo sapiens
832AC005095_11373100AC005095 pantophysinHomo sapiens
832S724811373100pantophysinHomo sapiens
832X681941373100h-Sp1Homo sapiens
833D14665385099KIAA0021 proteinHomo sapiens
833U41765381483metalloprotease/disintegrin/cysteineMus musculus
rich protein precursor
833U417664476100metalloprotease/disintegrin/cysteine-Homo sapiens
rich protein precursor
834U207701412100cell surface glycoproteinHomo sapiens
834U672741412100metastasis suppressorHomo sapiens
834X537951412100inducible membrane proteinHomo sapiens
835AF517934_12980100AF517934 interleukin 2 receptor,Homo sapiens
beta
835AL0223142980100dJ1170K4.3 (Interleukin 2Homo sapiens
Receptor, Beta (IL-2 Receptor,
CD122 antigen))
835BC0256912980100interleukin 2 receptor, betaHomo sapiens
836AF0722422167100methyl-CpG binding protein MBD2Homo sapiens
836AF1209942167100methyl-CpG binding protein 2Homo sapiens
836BC0326382167100methyl-CpG binding domain protein 2Homo sapiens
837AAH00486607100BC000486 small nuclearHomo sapiens
ribonucleoprotein D2 polypeptide
(16.5 kD)
837AAH01930607100BC001930 small nuclearHomo sapiens
ribonucleoprotein D2 polypeptide
(16.5 kD)
837AC007191_1607100AC007191 SMD2_HUMAN; SNRNP COREHomo sapiens
PROTEIN D2; SM-D2
838AAH18180870100BC018180 CGI-121 proteinHomo sapiens
838AF151879_1870100AF151879 CGI-121 proteinHomo sapiens
838BC029492870100CGI-121 proteinHomo sapiens
839U52373406399MNBHomo sapiens
839U58497403799mp86Mus musculus
839X79769405299Dual Specificity Yak1-relatedRattus
Kinase (Dyrk)norvegicus
853AF090949171097HBV-X associated protein 2Cercopithecus
aethiops
853U31913173699HBV-X associated proteinHomo sapiens
853U785211740100immunophilin homolog ARA9Homo sapiens
854AAH123331168100BC012333 Unknown (protein forHomo sapiens
MGC: 2084)
854AF187981_11168100AF187981 delta7-sterol-C5-Homo sapiens
desaturase
854D851811273100fungal sterol-C5-desaturaseHomo sapiens
homolog
856A84511101799unnamed protein productunidentified
856AF498970_11016100AF498970 small GTP bindingHomo sapiens
protein RhoA
856AX427410101799unnamed protein productunidentified
857AAH0431256394BC004312 insulin-like growthHomo sapiens
factor binding protein 2 (36 kD)
857AAH0990256394BC009902 Unknown (protein forHomo sapiens
MGC: 2339)
857AAH1276956394BC012769 Unknown (protein forHomo sapiens
MGC: 16256)
858AAH02434430100BC002434 p8 protein (candidate ofHomo sapiens
metastasis 1)
858AF069074430100P8 proteinHomo sapiens
858AF135266_1430100AF135266 p8 protein homologHomo sapiens
859AB04789230184hypothetical proteinMacaca
fascicularis
860AAH0119983399BC001199 Similar to glucoseHomo sapiens
regulated protein, 58 kDa
860AJ44072183399thioredoxin related proteinHomo sapiens
860AL83442383399hypothetical proteinHomo sapiens
861AAH008661124100BC000866 tissue inhibitor ofHomo sapiens
metalloproteinase 1 (erythroid
potentiating activity,
collagenase inhibitor)
861M599061124100collagenase inhibitorHomo sapiens
861X031241124100precursorHomo sapiens
862AAH00518112098BC000518 Similar to brain acid-Homo sapiens
soluble protein 1
862AF039656110596neuronal tissue-enriched acidicHomo sapiens
protein
862U9253581875neuronal axonal membrane proteinBos taurus
863AAH05931733100BC005931 hemoglobin, alpha 2Homo sapiens
863AAH08572733100BC008572 hemoglobin, alpha 2Homo sapiens
863BC032122733100hemoglobin, alpha 2Homo sapiens
864AF347006243691cytochrome c oxidase subunit IHomo sapiens
864AF382012242492cytochrome c oxidase subunit IHomo sapiens
864AF382013242492cytochrome c oxidase subunit IHomo sapiens
865AF242729_11242100AF242729 HT022Homo sapiens
865AJ2458741242100putative ATG/GTP binding proteinHomo sapiens
865AJ2503441242100hypothetical proteinHomo sapiens
866AAH170501367100BC017050 2,3-bisphosphoglycerateHomo sapiens
mutase
866M2306813671002,3-bisphosphoglycerateHomo sapiens
866X0432713671002,3 biphosphoglycerated mutaseHomo sapiens
(AA 1-259)
867AAH02334921100BC002334 DAZ associated protein 2Homo sapiens
867AAH07900921100BC007900 DAZ associated protein 2Homo sapiens
867D31767921100KIAA0058Homo sapiens
868AAH0957130898BC009571 Similar to stimulated byHomo sapiens
retinoic acid 13
868U9500630998D9 splice variant AHomo sapiens
868U9500727398D9 splice variant BHomo sapiens
869AAH1167475392BC011674 Similar to procollagen-Homo sapiens
lysine, 2-oxoglutarate 5-
dioxygenase 3
869AC004876_475392AC004876 lysyl hydroxylase 3Homo sapiens
869AF20706975392lysyl hydroxylase 3Homo sapiens
870AAH16765177899BC016765 Unknown (protein forHomo sapiens
MGC: 22663)
870AF153882_11785100AF153882 reversion-induced LIMHomo sapiens
protein
870AF154335_11785100AF154335 reversion-induced LIMHomo sapiens
protein
871AF023268154695metaxinHomo sapiens
871BC023071142487metaxinMus musculus
871U46920154695metaxinHomo sapiens
872AF193053_1575100AF193053 unknownHomo sapiens
873AF318351_13211100AF318351 unknownHomo sapiens
873AF318377_13211100AF318377 unknownHomo sapiens
873AX1067093211100unnamed protein productHomo sapiens
874AL3573742678100bA353C18.3.2 (splicing factorHomo sapiens
CC1.3, isoform 2 (CC1.4))
874AY061882266399transcription coactivator CAPERMus musculus
874L109112678100splicing factorHomo sapiens
875AAH08807280698BC008807 keratin 6AHomo sapiens
875AAH14152280998BC014152 Similar to keratin 6AHomo sapiens
875L42583280698keratin type IIHomo sapiens
876AK00049630172unnamed protein productHomo sapiens
876AK02511627167unnamed protein productHomo sapiens
876AK09051128260unnamed protein productHomo sapiens
877AAH16842243199BC016842 Unknown (protein forHomo sapiens
MGC: 10135)
877AK0276432435100unnamed protein productHomo sapiens
877AL834398252999hypothetical proteinHomo sapiens
878AAH025631624100BC002563 Similar to zinc/ironHomo sapiens
regulated transporter-like
878AAH078861624100BC007886 Unknown (protein forHomo sapiens
MGC: 14180)
878AAH143031624100BC014303 Unknown (protein forHomo sapiens
MGC: 16418)
879AF0567323342100prostaglandin transporterHomo sapiens
879BC041140347899solute carrier family 21Homo sapiens
(prostaglandin transporter),
member 2
879U708673342100prostaglandin transporter hPGTHomo sapiens
880AAH15206335100BC015206 guanine nucleotideHomo sapiens
binding protein 10
880AAH16319335100BC016319 guanine nucleotideHomo sapiens
binding protein 10
880AF493877_1335100AF493877 guanine nucleotideHomo sapiens
binding protein gamma 10
881BC010572133379Jun proto-oncogene related geneMus musculus
d1
881X51346151799jun-D gene product (AA 1-303)Homo sapiens
881X56681171698junD proteinHomo sapiens
882AY081680693100chlorophyll a/b-binding proteinArabidopsis
CP29thaliana
882AY133566693100At5g01530/F7A7_50Arabidopsis
thaliana
882BT000363693100chlorophyll a/b-binding proteinArabidopsis
CP29thaliana
883AY086905622100photosystem II type IArabidopsis
chlorophyll a/b binding protein,thaliana
putative
883AY128345622100photosystem II type I chlorophyllArabidopsis
a/b binding protein, putativethaliana
883BT000726622100putative photosystem II type IArabidopsis
chlorophyll a/b binding proteinthaliana
884AK074519152497unnamed protein productHomo sapiens
884AK074523152497unnamed protein productHomo sapiens
884AX1188671543100unnamed protein productHomo sapiens
885AY050935572100putative photosystem II type IArabidopsis
chlorophyll a/b binding proteinthaliana
885AY058180572100At1g29930/F1N18_23Arabidopsis
thaliana
885AY091169572100putative chlorophyll a/b-bindingArabidopsis
proteinthaliana
886AF178954214988monocarboxylate transporter 4Mus musculus
886U818002399100monocarboxylate transporterHomo sapiens
886U87627216488putative monocarboxylateRattus
transporternorvegicus
887AAH18345173100BC018345 Unknown (protein forHomo sapiens
MGC: 8802)
887AF237776_1173100AF237776 MAP kinase-interactingHomo sapiens
kinase 2b
887AL137565173100hypothetical proteinHomo sapiens
888AF006013377399dishevelled 3Homo sapiens
888BC032459378499dishevelled, dsh homolog 3Homo sapiens
(Drosophila)
888U756513806100dishevelled 3Homo sapiens
889AK0002682659100unnamed protein productHomo sapiens
889AK053678159871unnamed protein productMus musculus
889L00193134258epidermal keratin subunit IMus musculus
890AX354357840100unnamed protein productHomo sapiens
890BC00219824342Similar to hypothetical proteinMus musculus
FLJ20093
890BC03964265875Unknown (protein forMus musculus
IMAGE: 5352548)
891AF01234896292smooth muscle gamma actinGallus
gallus
891BC00204296292Similar to actin, gamma 2, smoothMus musculus
muscle, enteric
891S6349496292gamma-actinGallus
gallus
892AAH138672057100BC013867 Similar to palladinHomo sapiens
892AB023209206499KIAA0992 proteinHomo sapiens
892AF151909_12161100AF151909 CGI-151 proteinHomo sapiens
893AF287271_1714100AF287271 ribosomal protein L23Mus musculus
893AF401577_1714100AF401577 ribosomal protein L23Ictalurus
punctatus
893BC025918714100ribosomal protein L23Mus musculus
894U43916817100TMPHomo sapiens
894Y07909817100progression associated proteinHomo sapiens
894Z50751817100B4BHomo sapiens
895AAH09647277899BC009647 Unknown (protein forHomo sapiens
MGC: 5096)
895M13078277399alkaline phosphatase precursorHomo sapiens
895M191592780100placental alkaline phosphatase-1Homo sapiens
896AF3265912240100fenestrated-endothelial linkedHomo sapiens
structure protein
896AF348827223299PV1 proteinHomo sapiens
896AL834363230499hypothetical proteinHomo sapiens
897AAH116865877100BC011686 damage-specific DNAHomo sapiens
binding protein 1 (127 kD)
897L403265877100X-associated protein 1Homo sapiens
897U182995877100DDBa p127Homo sapiens
898U666611330100GABA-A receptor epsilon subunitHomo sapiens
898Y076371330100putative GABA-gated chlorideHomo sapiens
channel
898Y097651330100GABA receptor epsilon subunitHomo sapiens
899AF380181_11150699AF380181 SON DNA binding proteinHomo sapiens
isoform C
899AF380184_11219399AF380184 SON DNA binding proteinHomo sapiens
isoform F
899AY0268951187197NREBPHomo sapiens
900A20470214299preA-PAI-2synthetic
construct
900AAH126092148100BC012609 Similar to serine (orHomo sapiens
cysteine) proteinase inhibitor,
clade B (ovalbumin), member 2
900Y00630213999PAI-2 precursor (AA −22 to 393)Homo sapiens
901AB0378197936100KIAA1398 proteinHomo sapiens
901AL132765578595bA462D18.3.2 (ribosome bindingHomo sapiens
protein 1 (dog 180 kDa homolog)
(KIAA1398) (isoform 2))
901X87224651884ribosome receptorCanis
familiaris
902AAH00716264698BC000716 seryl-tRNA synthetaseHomo sapiens
902D49914264698Seryl tRNA SynthetaseHomo sapiens
902X91257264998seryl-tRNA synthetaseHomo sapiens
903D29640469857KIAA0051Homo sapiens
903L33075469857ras GTPase-activating-likeHomo sapiens
protein
903U519038003100RasGAP-related proteinHomo sapiens
904AAH17338257699BC017338 fucosidase, alpha-L-1,Homo sapiens
tissue
904M298772581100alpha-L-fucosidase precursor (ECHomo sapiens
3.2.1.5)
904M80815257699alpha-L-fucosidaseHomo sapiens
905AAH030673601100BC003067 growth arrest and DNA-Homo sapiens
damage-inducible 34
905AK001361356899unnamed protein productHomo sapiens
905U839813601100apoptosis associated proteinHomo sapiens
906AAH0271737977BC002717 Similar to chorionicHomo sapiens
somatomammotropin hormone 1
(placental lactogen)
906AAH0592137977BC005921 chorionicHomo sapiens
somatomammotropin hormone 1
(placental lactogen)
906AAH2075637977BC020756 chorionicHomo sapiens
somatomammotropin hormone 1
(placental lactogen)
907M579392349100ribonucleoprotein antigenHomo sapiens
907X04654325210070 K protein (AA 1-614)Homo sapiens
907X84841234910068 kDa (U1) ribonucleoproteinHomo sapiens
908AAH09945373799BC009945 Unknown (protein forHomo sapiens
IMAGE: 4123572)
908AB0182895502100KIAA0746 proteinHomo sapiens
908AK030487462087unnamed protein productMus musculus
909AJ422147664100C15 proteinHomo sapiens
909AX352692664100unnamed protein productHomo sapiens
909AX357061664100unnamed protein productHomo sapiens
910AF251294_137590AF251294 hCLA-isoHomo sapiens
910AL83443237590hypothetical proteinHomo sapiens
910AY03715037590hypothetical protein SB138Homo sapiens
911AAH015011520100BC001501 Unknown (protein forHomo sapiens
MGC: 2233)
911AAH140781520100BC014078 cyclin D1 (PRAD1:Homo sapiens
parathyroid adenomatosis 1)
911BC0253021520100cyclin D1 (PRAD1: parathyroidHomo sapiens
adenomatosis 1)
912BC0362851936100protein kinase, cAMP-dependent,Homo sapiens
regulatory, type I, alpha (tissue
specific extinguisher 1)
912M184681936100cAMP-dependent protein kinaseHomo sapiens
regulatory subunit type 1
912M333361936100cAMP-dependent protein kinaseHomo sapiens
type I-alpha subunit
913BC024165600100polymerase (RNA) II (DNAHomo sapiens
directed) polypeptide J (13.3 kD)
913X82385600100RNA polymerase II subunitHomo sapiens
913X98433600100RNA polymerase II subunitHomo sapiens
914AL138761803399bA16H23.2 (collagen, type XVII,Homo sapiens
alpha 1 (BP180))
914M916698228100autoantigenHomo sapiens
914U76604803799180 kDa bullous pemphigoidHomo sapiens
antigen 2/type XVII collagen
915AAH035752373100BC003575 mannosyl (alpha-1,3-)-Homo sapiens
glycoprotein beta-1,2-N-
acetylglucosaminyltransferase
915M55621236399N-acetylglucosaminyltransferase IHomo sapiens
915M618292373100alpha-1,3-mannosyl-glycoproteinHomo sapiens
beta-1,2-N-
acetylglucosaminyltransferase
916L139231663999fibrillinHomo sapiens
916L287481636297putativeBos taurus
916X6355617359100fibrillinHomo sapiens
917AAH025763661100BC002576 matrix metalloproteinaseHomo sapiens
2 (gelatinase A, 72 kD gelatinase,
72 kD type IV collagenase)
917J032103584100collagenase type IV precursorHomo sapiens
917M555933661100type IV collagenaseHomo sapiens
918AAH22087246699BC022087 Similar to CD36 antigenHomo sapiens
(collagen type I receptor,
thrombospondin receptor)-like 1
918AF467889_1238086AF467889 high density lipoproteinSus scrofa
receptor SR-BI
918Z225552684100CLA-1Homo sapiens
919AF106202_11249100AF106202 endothelial cell proteinHomo sapiens
C receptor precursor
919AF375468_11249100AF375468 endothelial protein CHomo sapiens
receptor
919X890791249100centrocyclinHomo sapiens
920AF153603_1666100AF153603 TSC-22 related proteinHomo sapiens
920AF183393_1666100AF183393 TSC-22-like ProteinHomo sapiens
920AF228339666100glucocorticoid-induced GILZHomo sapiens
921AF111168358699unknownHomo sapiens
921AK075445287699unnamed protein productHomo sapiens
921AX136231287699unnamed protein productHomo sapiens
922AAH112341220100BC011234 Similar to splicingHomo sapiens
factor 30, survival of motor
neuron-related
922AF083385122010030 kDa splicing factor; SPF 30Homo sapiens
922AF1074631220100splicing factorHomo sapiens
923AAH102401921100BC010240 cathepsin BHomo sapiens
923L16510191299cathepsin BHomo sapiens
923M14221191599preprocathepsin BHomo sapiens
924AK05603349597unnamed protein productHomo sapiens
925AE00358820522CG2839-PADrosophila
melanogaster
925AE014836_2123126AE014836 hypothetical proteinPlasmodium
falciparum
3D7
925AY05212720222SD07741pDrosophila
melanogaster
926AF222743_12415100AF222743 Sec61 alpha-1Mus musculus
926BC0037072415100sec61 homologMus musculus
926M966302415100sec61-like proteinRattus sp.
927AF332086_1319396AF332086 Rad21Mus musculus
927D385513284100The ha1237 gene product isHomo sapiens
related to S. pombe rad21 gene
product.
927X98294327599HR21spAHomo sapiens
928AAH16325925100BC016325 ADP-ribosylation factor 4Homo sapiens
928AF493883_1925100AF493883 ADP-ribosylation factorHomo sapiens
protein 4
928BC022866925100ADP-ribosylation factor 4Homo sapiens
929AAH18201763100BC018201 Unknown (protein forHomo sapiens
MGC: 21505)
929AF217965_1763100AF217965 unknownHomo sapiens
929AF217972_1763100AF217972 unknownHomo sapiens
930AAH002111162100BC000211 eukaryotic translationHomo sapiens
elongation factor 1 beta 2
930AAH049311162100BC004931 eukaryotic translationHomo sapiens
elongation factor 1 beta 2
930X604891162100elongation factor-1-betaHomo sapiens
931D82984175893C/EBP alpha proteinBos taurus
931U34070185796CCAAT/enhancer binding proteinHomo sapiens
alpha
931Y115251927100CCAAT/enhancer binding proteinHomo sapiens
alpha
932AK02511634171unnamed protein productHomo sapiens
932AK09051135872unnamed protein productHomo sapiens
932AK09637334170unnamed protein productHomo sapiens
933AAH139632458100BC013963 Similar to adenylylHomo sapiens
cyclase-associated protein
933AAH171962458100BC017196 adenylyl cyclase-Homo sapiens
associated protein
933M984742458100CAP proteinHomo sapiens
934AAH02464217599BC002464 coagulation factor IIHomo sapiens
(thrombin) receptor
934AF391809_1217999AF391809 coagulation factor IIHomo sapiens
(thrombin) receptor
934M624242187100thrombin receptorHomo sapiens
935AF085250759100calmodulinPerca
flavescens
935D83350759100calmodulinAnas
platyrhynchos
935K01945759100calmodulin (cDNA clone 71)Xenopus
laevis
936AL0502652193100hypothetical proteinHomo sapiens
936BC033475212896similar to TAR DNA-bindingMus musculus
protein-43 (TDP-43)
936U237312193100TAR DNA-binding protein-43Homo sapiens
937AAH01495167399BC001495 chromosome 1 openHomo sapiens
reading frame 8
937AAH163741697100BC016374 chromosome 1 openHomo sapiens
reading frame 8
937AF290615_1167399AF290615 liver membrane-boundHomo sapiens
protein
938AK00038532965unnamed protein productHomo sapiens
938AK09245036069unnamed protein productHomo sapiens
938AK09726632974unnamed protein productHomo sapiens
939AAH0064268399BC000642 MY047 proteinHomo sapiens
939AF063605688100brain my047 proteinHomo sapiens
939AX13611968399unnamed protein productHomo sapiens
940AF035947_11394100AF035947 cytokine-inducibleHomo sapiens
inhibitor of signalling type 1b
940AF132297_1133299AF132297 cytokine-inducible SH2-Homo sapiens
containing protein
940BC0315901321100cytokine inducible SH2-containingHomo sapiens
protein
941AF151018_1955100AF151018 HSPC184Homo sapiens
941AK01204795199unnamed protein productMus musculus
941AK075227955100unnamed protein productHomo sapiens
942AK02511632270unnamed protein productHomo sapiens
942AK09051130263unnamed protein productHomo sapiens
942AK09092930871unnamed protein productHomo sapiens
943AAH093571052100BC009357 transgelin 2Homo sapiens
943AY0071271157100similar to Homo sapiens mRNA for
KIAA0120 gene with GenBank
Accession Number D21261.1
943D212611052100similar to human 22 kDa, SM22 mRNAHomo sapiens
(HUM22SM).
945AAH1400626089BC014006 Similar to 6-Homo sapiens
phosphogluconolactonase
945AJ243972260896-phosphogluconolactonaseHomo sapiens
945BC00659424380RIKEN cDNA 1110030K05 geneMus musculus
946AAH03125205599BC003125 Unknown (protein forHomo sapiens
MGC: 3222)
946AK027877205599unnamed protein productHomo sapiens
946AL136916205599hypothetical proteinHomo sapiens
947AAH036812956100BC003681 Unknown (protein forHomo sapiens
IMAGE: 3453235)
947AL0968283008100dJ963E22.1 (Novel protein similarHomo sapiens
to NY-REN-2 Antigen)
947AX400070287896unnamed protein productHomo sapiens
948AF161372_1872100AF161372 HSPC254Homo sapiens
949AAH11714476100BC011714 Similar to heterogeneousHomo sapiens
nuclear ribonucleoprotein D-like
949AB017020476100JKTBPMus musculus
949BC021374476100heterogeneous nuclearMus musculus
ribonucleoprotein D-like
950AAH026731063100BC002673 protein kinase H11;Homo sapiens
small stress protein-like protein
HSP22
950AF191017_11063100AF191017 E2IG1Homo sapiens
950AF250138_11063100AF250138 small stress protein-Homo sapiens
like protein HSP22
951AAH05033471899BC005033 Unknown (protein forHomo sapiens
MGC: 12692)
951AJ289242465497alpha-actinin 4Mus musculus
951BC013616465497alpha actinin 4Mus musculus
952AAH119081787100BC011908 Unknown (protein forHomo sapiens
MGC: 20321)
952AAH145641787100BC014564 Unknown (protein forHomo sapiens
MGC: 2063)
952AAH186951787100BC018695 Unknown (protein forHomo sapiens
MGC: 3838)
953AAH129771363100BC012977 nuclear LIM interactor-Homo sapiens
interacting factor
953AF229162_11363100AF229162 nuclear LIM interactor-Homo sapiens
interacting factor
953AF2291631363100nuclear LIM interactor-Homo sapiens
interacting factor
954AAH0971855792BC009718 epithelial membraneHomo sapiens
protein 3
954U5210155792YMPHomo sapiens
954U8794755792hematopoietic neural membraneHomo sapiens
protein
955AF162781_1498694AF162781 SH2-containing inositolMus musculus
5-phosphatase 2
955L3681860449951C proteinHomo sapiens
955Y14385527098inositol polyphosphate 5-Homo sapiens
phosphatase
956AAH173691238100BC017369 splicing factor,Homo sapiens
arginine/serine-rich 7 (35 kD)
956AAH179081238100BC017908 splicing factor,Homo sapiens
arginine/serine-rich 7 (35 kD)
956BC0223281238100splicing factor, arginine/serine-Homo sapiens
rich 7 (35 kD)
957AAH14323120999BC014323 Similar to accessoryHomo sapiens
proteins BAP31/BAP29
957X811091213100tumor-associated antigenHomo sapiens
957Z316961213100CDMHomo sapiens
958AAH157633102100BC015763 hypothetical proteinHomo sapiens
FLJ20258
958AK000265309399unnamed protein productHomo sapiens
958AK075098299899unnamed protein productHomo sapiens
959AAH078582250100BC007858 inhibin, beta A (activinHomo sapiens
A, activin AB alpha polypeptide)
959M134362250100beta-A inhibinHomo sapiens
959X575782250100activin beta-A subunitHomo sapiens
960AK0275983474100unnamed protein productHomo sapiens
960AX481758349299unnamed protein productHomo sapiens
960AX481760349299unnamed protein productHomo sapiens
961AAH159583278100BC015958 Unknown (protein forHomo sapiens
MGC: 15290)
961BC0235203278100Unknown (protein for MGC: 12727)Homo sapiens
961U681053278100poly(A)-binding proteinHomo sapiens
962AAH10623372996BC010623 Similar to nuclearHomo sapiens
factor (erythroid-derived 2)-like 1
962AK0904594032100FLJ00380 proteinHomo sapiens
962X773663926100hbZ17Homo sapiens
963AAH031773500100BC003177 KIAA1536 proteinHomo sapiens
963AK027881348099unnamed protein productHomo sapiens
963AL1368953500100hypothetical proteinHomo sapiens
964AY054301498194type III preprocollagen alpha 1Homo sapiens
chain
964BC0281786603100Similar to collagen, type III,Homo sapiens
alpha 1 (Ehlers-Danlos syndrome
type IV, autosomal dominant)
964X14420498194prepro-alpha-1 type 3 collagenHomo sapiens
965AAH11819347399BC011819 DEAD/H (Asp-Glu-Ala-Homo sapiens
Asp/His) box polypeptide 3
965AF0009823476100dead box, X isoformHomo sapiens
965AF0009833476100dead box, X isoformHomo sapiens
966AAH149591160100BC014959 RING1 and YY1 bindingHomo sapiens
protein
966AF179286_11160100AF179286 death effector domain-Homo sapiens
associated factor
966BC036459115699RING1 and YY1 binding proteinHomo sapiens
967AAH1717263499BC017172 hypothetical proteinHomo sapiens
967AF110774_163499AF110774 adrenal gland proteinHomo sapiens
AD-001
967AX35435563499unnamed protein productHomo sapiens
968AAH084421106100BC008442 Similar to transmembraneHomo sapiens
4 superfamily member 1
968AAH101661106100BC010166 Similar to transmembraneHomo sapiens
4 superfamily member 1
968M906571106100L6Homo sapiens
969AAH103541764100BC010354 PTD010 proteinHomo sapiens
969AB0096851764100DERP2Homo sapiens
969AF1318201764100UnknownHomo sapiens
970AF217787117299extracellular glutathioneHomo sapiens
peroxidase
970D006321195100glutathione peroxidaseHomo sapiens
970X582951195100glutathione peroxidaseHomo sapiens
971AAH0053193997BC000531 insulin-like growthHomo sapiens
factor 2 (somatomedin A)
971AF517226_193997AF517226 insulin-like growthHomo sapiens
factor 2 (somatomedin A)
971M1786394297preproinsulin-like growth factorHomo sapiens
II, domains A-E
972AJ3105442183100EGLN2 proteinHomo sapiens
972AX5538642183100unnamed protein productHomo sapiens
972BC0360512183100Similar to egl nine homolog 2 (C. elegans)Homo sapiens
973AAH0086791598BC000867 PRO0659 proteinHomo sapiens
973AL834135111899hypothetical proteinHomo sapiens
973AX405861111899unnamed protein productHomo sapiens
974AL136890129398hypothetical proteinHomo sapiens
974AL13779887880dJ1182A14.5.2 (novel geneHomo sapiens
(isoform 2) KIAA1245 protein)
974BC0240111747100Similar to hypothetical proteinHomo sapiens
DKFZp434D177
975AB037755489699KIAA1334 proteinHomo sapiens
975AF155135_1484599AF155135 novel retinal pigmentHomo sapiens
epithelial cell protein
975AF202315_1414185AF202315 ankycorbinMus musculus
976AK09796534477unnamed protein productHomo sapiens
976AX40000828362unnamed protein productHomo sapiens
976BC03395934270similar to Alu subfamily SQHomo sapiens
sequence contamination warning
entry
977AAH124441319100BC012444 Similar to chlorideHomo sapiens
intracellular channel 4
977AF097330_1130599AF097330 H1 chloride channel;Homo sapiens
p64H1; CLIC4
977AL1174241319100hypothetical proteinHomo sapiens
978AB034747904100small integral membrane proteinHomo sapiens
of lysosome/late endosome
978AF17110081285TBX1 proteinMus musculus
978BC01855981285LPS-induced TNF-alpha factorMus musculus
979AAH106451737100BC010645 Similar toHomo sapiens
sialyltransferase 4C (beta-
galactosidase alpha-2,3-
sialytransferase)
979AY040826171597alpha 2,3-sialyltranferase IVHomo sapiens
type B + 18
979L237671710100a2,3 sialyltransferseHomo sapiens
980AAH0932988782BC009329 triosephosphateHomo sapiens
isomerase 1
980AAH1161188782BC011611 Similar toHomo sapiens
triosephosphate isomerase 1
980AAH1510088782BC015100 triosephosphateHomo sapiens
isomerase 1
981AAH18986133898BC018986 Unknown (protein forHomo sapiens
MGC: 20092)
981J05594133198NAD+-dependent 15-Homo sapiens
hydroxyprostaglandin
dehydrogenase
981L76465133198NAD+-dependent 15-Homo sapiens
hydroxyprostaglandin
dehydrogenase
982AAH00690794100BC000690 ribosomal protein L24Homo sapiens
982BC002110794100ribosomal protein L24Mus musculus
982X78443794100ribosomal protein L24Rattus
norvegicus
983AAH114021122100BC011402 Similar to decidualHomo sapiens
protein induced by progesterone
983AB0227181122100DEPPHomo sapiens
983AL136653111699hypothetical proteinHomo sapiens
984AF10884140674pol proteinHomo sapiens
984AF10884342075pol proteinHomo sapiens
984U8890231973integraseHomo sapiens
985A07358165799VAC betaMus musculus
985AAH043761666100BC004376 annexin A8Homo sapiens
985X16662165799vascular anticoagulant-beta (AA 1-327)Homo sapiens
986AF0682272236100putative transmembrane proteinHomo sapiens
986AK032293142676unnamed protein productMus musculus
986BC025487144777Similar to ceroid-lipofuscinosis,Mus musculus
neuronal 5
987AAH106521355100BC010652 Unknown (protein forHomo sapiens
MGC: 9753)
987AF217980_1133898AF217980 unknownHomo sapiens
988AK00049637868unnamed protein productHomo sapiens
988AK02511640372unnamed protein productHomo sapiens
988AK09051136368unnamed protein productHomo sapiens
989AF0019001702100secreted frizzled-related proteinHomo sapiens
989AF0560871702100secreted frizzled related proteinHomo sapiens
989BC036503169099Unknown (protein for MGC: 43294)Homo sapiens
990AAH140522127100BC014052 transcriptional coactivatorHomo sapiens
with PDZ-binding motif
(TAZ)
990AJ2994312127100transcriptional coactivatorHomo sapiens
990AK0220362127100unnamed protein productHomo sapiens
991AAH0749355299BC007493 galactosidase, beta 1Homo sapiens
991M2259055299beta-galactosidase precursor (ECHomo sapiens
3.2.1.23)
991M3442355299beta-galactosidase precursor (ECHomo sapiens
3.2.1.23)
992AAH159282186100BC015928 Unknown (protein forHomo sapiens
MGC: 8773)
992AB0377972313100KIAA1376 proteinHomo sapiens
992AK088288215398unnamed protein productMus musculus
993AF087873_1383100AF087873 protein kinase inhibitorHomo sapiens
993AF225513_1383100AF225513 cAMP-dependent proteinHomo sapiens
kinase inhibitor beta
993BC036011383100protein kinase (cAMP-dependent,Homo sapiens
catalytic) inhibitor beta
994X53305736100stathminHomo sapiens
994X94912736100Pr22Homo sapiens
994Z11566736100Pr22 proteinHomo sapiens
995AF148856_215079AF148856 unknownHomo sapiens
995AL09674415382hypothetical proteinHomo sapiens
995M8034115079ORF2Homo sapiens
996AK00215479894unnamed protein productHomo sapiens
996AK023417819100unnamed protein productHomo sapiens
996AX39994923064unnamed protein productHomo sapiens
997AF151807_1219699AF151807 CGI-49 proteinHomo sapiens
997AK075178214997unnamed protein productHomo sapiens
997BC026185213697Similar to CGI-49 proteinHomo sapiens
998AAH101232134100BC010123 SH3-domain bindingHomo sapiens
protein 5 (BTK-associated)
998AB0050472134100SH3 binding proteinHomo sapiens
998AB027562200894vascular endothelial cellRattus
specific protein 18norvegicus
999AJ131023530999oxytocinase/insulin-responsiveHomo sapiens
aminopeptidase, variant 1
999U62768531899oxytocinase splice variant 1Homo sapiens
999U62769524299oxytocinase splice variant 2Homo sapiens
1000AF234263252199cathepsin CHomo sapiens
1000U794152527100prepro dipeptidyl peptidase IHomo sapiens
1000X872122527100cathepsin CHomo sapiens
1001BC003426143894Similar to eukaryotic translationMus musculus
initiation factor 2B, subunit 1
(alpha, 26 kD)
1001U05821141992translation initiation factorRattus
eIF-2B alpha-subunitnorvegicus
1001X956481526100alfa subunitHomo sapiens
1002AAH14093407396BC014093 Similar to amilorideHomo sapiens
binding protein 1 (amine oxidase
(copper-containing))
1002U11862406096diamine oxidase, copper/topaHomo sapiens
quinone-containing
1002X78212406696amiloride binding proteinHomo sapiens
1003AK00363392598unnamed protein productMus musculus
1003AK00798992598unnamed protein productMus musculus
1003AK07621292598unnamed protein productMus musculus
1004AAH18340169299BC018340 Unknown (protein forHomo sapiens
MGC: 9372)
1004X79066169299ERF-1Homo sapiens
1004X99404168499Berg36Homo sapiens
1005AB05597749293I3 proteinHomo sapiens
1005AF04143049293pRGR2Homo sapiens
1005AF10696649293I3 proteinHomo sapiens
1006AAH144381018100BC014438 Unknown (protein forHomo sapiens
MGC: 22947)
1006AE006639_31018100AE006639 HN1 likeHomo sapiens
1006AK0231541018100unnamed protein productHomo sapiens
1007J037793944100common acute lymphoblasticHomo sapiens
leukemia antigen precursor
1007M26628391999enkephalinaseHomo sapiens
1007Y00811391999CALLA protein (AA 1-750)Homo sapiens
1008AB0353044092100cadherin-5Homo sapiens
1008U84722408699vascular endothelial cadherinHomo sapiens
1008X799814092100VE-cadherinHomo sapiens
1009AX019983739100unnamed protein productHomo sapiens
1009BC026254739100insulin-like 4 (placenta)Homo sapiens
1009L34838739100EPILHomo sapiens
1010AF139894_11813100AF139894 RNA-binding proteinMus musculus
alpha-CP1
1010AF139895_11813100AF139895 RNA-binding proteinMus musculus
alpha-CP1
1010BC0047931813100poly (rC)-binding protein 1Mus musculus
1011U1239036688beta-galactosidase alpha peptideCloning
vector
pSport1
1011U1239135588beta-galactosidase alpha peptideCloning
vector
pSport2
1011Y1483629077beta-galactosidasePhagemid
cloning
vector
pTZ19U
1012AF218012_11751100AF218012 unknownHomo sapiens
1012AF218030_11751100AF218030 unknownHomo sapiens
1012AL121586200088dJ47704.1.1 (novel proteinHomo sapiens
similar to otoferlin and
dysferlin, isoform 1)
1013AAH003521286100BC000352 proteasome (prosome,Homo sapiens
macropain) activator subunit 1
(PA28 alpha)
1013AAH075031286100BC007503 proteasome (prosome,Homo sapiens
macropain) activator subunit 1
(PA28 alpha)
1013AF078829_11286100AF078829 proteasome activatorHomo sapiens
PA28 alpha
1014AAH1615552189BC016155 Ras homolog enriched inHomo sapiens
brain 2
1014AF493921_152189AF493921 Ras family small GTPHomo sapiens
binding protein RHEB2
1014Z2967752189Ras-related GTP-binding proteinHomo sapiens
1015AAH104232657100BC010423 Ig superfamily receptorHomo sapiens
LNIR
1015AF160477_1265599AF160477 Ig superfamily receptorHomo sapiens
LNIR precursor
1015AF426163_12657100AF426163 nectin 4Homo sapiens
1016AJ295142357899C1q receptor proteinHomo sapiens
1016BC028075357799complement component 1, qHomo sapiens
subcomponent, receptor 1
1016U943333587100C1qR(p)Homo sapiens
1017AAH142713392100BC014271 endoglin (Osler-Rendu-Homo sapiens
Weber syndrome 1)
1017J05481331999endoglin precursorHomo sapiens
1017U37439338599endoglinHomo sapiens
1018AAH0741154086BC007411 Unknown (protein forHomo sapiens
MGC: 2554)
1018AF05178253685diaphanous 1Homo sapiens
1018U9696349580p140mDiaMus musculus
1019AF151966_1187566AF151966 GTPase activatingGallus
protein Rap1-GAPgallus
1019BC030891210995Unknown (protein forMus musculus
IMAGE: 4485689)
1019M647883477100GTPase activating proteinHomo sapiens
1020AX2067081968100unnamed protein productHomo sapiens
1020M929341968100connective tissue growth factorHomo sapiens
1020X789471968100connective tissue growth factorHomo sapiens
1021AAH18823849100BC018823 Unknown (protein forHomo sapiens
MGC: 1236)
1021AK00772980997unnamed protein productMus musculus
1021U30826849100SRp40-1Homo sapiens
1022AAH073332823100BC007333 ets variant gene 5 (ets-Homo sapiens
related molecule)
1022X761842823100ets-related proteinHomo sapiens
1022X963812823100ermHomo sapiens
1023AAH0259999699BC002599 corticotropin releasingHomo sapiens
hormone
1023AAH1103199699BC011031 Similar to corticotropinHomo sapiens
releasing hormone
1023V0057199699corticotropin releasing factorHomo sapiens
1024AK007731116494unnamed protein productMus musculus
1024AL110239123499hypothetical proteinHomo sapiens
1024AX3998651355100unnamed protein productHomo sapiens
1025AAH007321553100BC000732 glioblastoma amplifiedHomo sapiens
sequence
1025AAH018371553100BC001837 glioblastoma amplifiedHomo sapiens
sequence
1025BC0308211553100glioblastoma amplified sequenceHomo sapiens
1026AAH014832103100BC001483 Unknown (protein forHomo sapiens
MGC: 1364)
1026AAH092412103100BC009241 Unknown (protein forHomo sapiens
MGC: 3556)
1026BC0235992103100TRK-fused geneHomo sapiens
1027AAH128063278100BC012806 solute carrier family 5Homo sapiens
(sodium-dependent vitamin
transporter), member 6
1027AAH156313278100BC015631 solute carrier family 5Homo sapiens
(sodium-dependent vitamin
transporter), member 6
1027AF116241327299sodium-dependent multivitaminHomo sapiens
transporter
1029AAH04324744100BC004324 ribosomal protein S16Homo sapiens
1029AAH07977744100BC007977 ribosomal protein S16Homo sapiens
1029X17665744100ribosomal protein S16 (AA 1-146)Rattus
Rattus
1030AB04755562490IZP6Mus musculus
musculus
1030AK00794862490unnamed protein productMus musculus
1030BC00472962490RIKEN cDNA 1810063P04 geneMus musculus
1031BC0033371957100actin, gamma 1Mus musculus
1031BC0217961957100actin, gamma 1Mus musculus
1031BC0232481957100actin, gamma, cytoplasmicMus musculus
1032AAH117002048100BC011700 glutamate-ammonia ligaseHomo sapiens
(glutamine synthase)
1032AAH118522048100BC011852 glutamate-ammonia ligaseHomo sapiens
(glutamine synthase)
1032AAH189922048100BC018992 Unknown (protein forHomo sapiens
MGC: 20095)
1033AF234654_11155100AF234654 PLAC1Homo sapiens
1033AK0750861155100unnamed protein productHomo sapiens
1033BC0223351155100placenta-specific 1Homo sapiens
1034AAB67977410899AF019413 complement factor BHomo sapiens
1034AAH041434121100BC004143 B-factor, properdinHomo sapiens
1034AAH079904121100BC007990 B-factor, properdinHomo sapiens
1035AAH1739935598BC017399 Similar to RIKEN cDNAHomo sapiens
1810037I17 gene
1035AK00772123668unnamed protein productMus musculus
1035BC00213523668Unknown (protein for MGC: 7243)Mus musculus
1036AAH133831701100BC013383 calumeninHomo sapiens
1036AF0137591701100calumeinHomo sapiens
1036U67280169599calumeninHomo sapiens
1037AF06906559697inducible cAMP early repressorHomo sapiens
type 1
1037AJ31166758895induced cAMP early repressor,Mus musculus
ICER I
1037D14826608100hCREM 2alpha-a proteinHomo sapiens
1038AAH004521043100BC000452 Similar to thioredoxinHomo sapiens
peroxidase 1
1038AAH030221043100BC003022 Similar to thioredoxinHomo sapiens
peroxidase 1
1038BC0394281043100Similar to peroxiredoxin 2Homo sapiens
1039AB0561072995100zinc finger protein homologous toHomo sapiens
mouse Zfp91
1039AB0574432775100testis specific ZFP91Homo sapiens
1039AF310246_1258699AF310246 FKSG11Homo sapiens
1040AF0234764954100meltrin-L precursorHomo sapiens
1040AF023477385599meltrin-SHomo sapiens
1040D50411393980meltrin alphaMus musculus
1041AF154121_13126100AF154121 sodium-dependent high-Homo sapiens
affinity dicarboxylate
transporter
1041AY072810305798energy metabolism-related sodium-Homo sapiens
dependent high-affinity
dicarboxylate transporter
1041BC035966305698similar to solute carrier familyHomo sapiens
13 (sodium-dependent
dicarboxylate transporter),
member 3
1042AF40059468764endothelial nitric oxide synthaseHomo sapiens
1042AF519768_168764AF519768 nitric oxide synthase 3Homo sapiens
(endothelial cell)
1042L2691468764nitric oxide synthaseHomo sapiens
1043AAH014621835100BC001462 protease, serine, 8Homo sapiens
(prostasin)
1043L413511835100prostasinHomo sapiens
1043U334461835100prostasinHomo sapiens
1044AB05144230471KIAA1655 proteinHomo sapiens
1044AK09091335864unnamed protein productHomo sapiens
1044BC02465127676similar to PRO2550Homo sapiens
1045AF346465729191latent transforming growth factorMus musculus
beta binding protein 1S
1045AF489528_1788799AF489528 transforming growthHomo sapiens
factor-beta binding protein-1S
1045M340577903100transforming growth factor-beta 1Homo sapiens
binding protein precursor
1046AY004254119990endoplasmic reticulum protein 29Rattus
precursornorvegicus
1046X949101334100ERp28Homo sapiens
1046Y10264119990ERp29 precursorRattus
norvegicus
1047AF119917_58250100AF119896 PRO2751Homo sapiens
1048AB0206924158100KIAA0885 proteinHomo sapiens
1048BC016898410798Unknown (protein for MGC: 19174)Mus musculus
1048X52311410298unr protein (AA 1-798)Rattus
norvegicus
1050AL049698703498dJ470B24.1.3 (myeloid/lymphoid orHomo sapiens
mixed-lineage leukemia (trithorax
(Drosophila) homolog);
translocated to, 4 (AF-6)
(isoform 3))
1050AL049698705098dJ470B24.1.5 (myeloid/lymphoid orHomo sapiens
mixed-lineage leukemia (trithorax
(Drosophila) homolog);
translocated to, 4 (AF-6)
(isoform 5))
1050AL1619737363100hypothetical proteinHomo sapiens
1051AAH212882134100BC021288 Unknown (protein forHomo sapiens
MGC: 29494)
1051J03263193498membrane glycoproteinHomo sapiens
1051J04182204196lysosomal membrane glycoprotein-1Homo sapiens
1052AC002400817100Acyl carrier protein,Homo sapiens
Mitochondrial (ACP) (5′partial)
1052AF087660_1788100AF087660 NADH: ubiquinoneHomo sapiens
oxidoreductase SDAP subunit
1052AK01871767285unnamed protein productMus musculus
1053AB031550149095pctp-LMus musculus
1053AF151810_1185398AF151810 CGI-52 proteinHomo sapiens
1053Z8113447741Hypothetical protein T28D6.7Caenorhabditis
elegans
1055AAH09392530699BC009392 Unknown (protein forHomo sapiens
MGC: 15329)
1055AB0111495318100KIAA0577 proteinHomo sapiens
1055AP0005125318100RNA helicaseHomo sapiens
1056AAH08751375799BC008751 calpain 1, (mu/I) largeHomo sapiens
subunit
1056AAH172003762100BC017200 calpain 1, (mu/I) largeHomo sapiens
subunit
1056X043663762100CANP, large subunit (aa 1-714)Homo sapiens
1057AB093679740100ribosomal protein L26Macaca
fascicularis
1057X69392740100ribosomal protein L26Homo sapiens
1057X80699740100L26Mus musculus
1058AAH063911974100BC006391 inhibin, alphaHomo sapiens
1058M139811974100inhibin A-subunit precursorHomo sapiens
1058X044451974100preproinhibinHomo sapiens
1059AK00038526765unnamed protein productHomo sapiens
1059AK09245027058unnamed protein productHomo sapiens
1059AK09721435474unnamed protein productHomo sapiens
1060AF130117_4835777AF130089 PRO2550Homo sapiens
1060AK00038536375unnamed protein productHomo sapiens
1060U2237632776alternatively spliced productHomo sapiens
using exon 13A
1061AF090930_117251AF090930 PRO0478Homo sapiens
1061AX39991915868unnamed protein productHomo sapiens
1062AF063591_1140199AF063591 brain my033 proteinHomo sapiens
1062BC0225221411100antigen identified by monoclonalHomo sapiens
antibody MRC OX-2
1062BC0311031411100antigen identified by monoclonalHomo sapiens
antibody MRC OX-2
1063AAH006922582100BC000692 Similar toHomo sapiens
hyaluronoglucosaminidase 2
1063AC002455257999human PH-20 homolog (LUCA-2)Homo sapiens
1063U09577257999lysosomal hyaluronidaseHomo sapiens
1064AAH027002294100BC002700 Similar to keratin 7Homo sapiens
1064AF5098872294100keratin 7Homo sapiens
1064AF5098922294100keratin 7Homo sapiens
1065AF523361_1195199AF523361 CD34 antigenHomo sapiens
1065M819451955100hematopoietic stem cell antigenHomo sapiens
1065S53910195199CD34Homo sapiens
1066AB037891493100Bc10Mus musculus
1066AF303656_1493100AF303656 bladder cancer-relatedMus musculus
protein
1066BC026935493100bladder cancer associated proteinMus musculus
1067AF3229093026100transmembrane glycoprotein HGFINHomo sapiens
1067BC032783300397Similar to glycoproteinHomo sapiens
(transmembrane) nmb
1067X765343026100NMBHomo sapiens
1068AAH173523091100BC017352 Unknown (protein forHomo sapiens
MGC: 29525)
1068AF230388_1308599AF230388 tripartite motif proteinHomo sapiens
TRIM29 alpha
1068L24203308599ataxia-telangiectasia group D-Homo sapiens
associated protein
1069AK003609103299unnamed protein productMus musculus
1069AL1366351039100hypothetical proteinHomo sapiens
1069BC016408103299RIKEN cDNA 1110011F09 geneMus musculus
1070AF0733107103100insulin receptor substrate-2Homo sapiens
1070AF385932_1701499AF385932 insulin receptorHomo sapiens
substrate 2 insertion mutant
1070AF385933_1702699AF385933 insulin receptorHomo sapiens
substrate 2 insertion mutant
1071AAH09586219891BC009586 Unknown (protein forHomo sapiens
MGC: 14649)
1071D26485219891core I proteinHomo sapiens
1071L16842219390ubiquinol-cytochrome c reductaseHomo sapiens
core I protein
1072AF0625341919100genethonin 1Homo sapiens
1072AK050416108362unnamed protein productMus musculus
1072BC0223011919100genethonin 1Homo sapiens
1073AAH08950956100BC008950 Unknown (protein forHomo sapiens
MGC: 3593)
1073AF112202_1956100AF112202 prenylated rab acceptor 1Homo sapiens
1073AJ13353495199prenylated Rab acceptor 1 (PRA1)Homo sapiens
1074AAH14257888100BC014257 Similar to DKFZp564J157Homo sapiens
protein
1074AAH16064888100BC016064 DKFZp564J157 proteinHomo sapiens
1074AX405840888100unnamed protein productHomo sapiens
1075AAH023942275100BC002394 ceroid-lipofuscinosis,Homo sapiens
neuronal 3, juvenile (Batten,
Spielmeyer-Vogt disease)
1075AAH044332275100BC004433 ceroid-lipofuscinosis,Homo sapiens
neuronal 3, juvenile (Batten,
Spielmeyer-Vogt disease)
1075U326802275100CLN3 proteinHomo sapiens
1076AF443072_12009099AF443072 laminin alpha5 chainHomo sapiens
precursor
1076AL3548362006399bA157P1.1.1 (laminin alpha 5)Homo sapiens
1076AX4637382009099laminin 5Homo sapiens
1077BC024366703100ribosomal protein L27Mus musculus
1077X07424703100ribosomal protein L27 (AA 1-136)Rattus
norvegicus
1077X56852703100ribosomal protein L27Gallus
gallus
1078AAH13131969100BC013131 Similar to hypotheticalHomo sapiens
protein FLJ10702
1078AK001564969100unnamed protein productHomo sapiens
1078BC013719969100hypothetical protein FLJ10702Mus musculus
1079AF214737_15676100AF214737 C9orf10aHomo sapiens
1079BC010304376593Unknown (protein forMus musculus
IMAGE: 3597827)
1079D800055676100KIAA0183Homo sapiens
1080AF113127_1118699AF113127 S1R proteinHomo sapiens
1080AF151877_1124299AF151877 CGI-119 proteinHomo sapiens
1080AF182041_1118699AF182041 z-proteinHomo sapiens
1081AAH116161514100BC011616 Similar to cyclin D3Homo sapiens
1081AF517525_1151199AF517525 cyclin D3Homo sapiens
1081M922871514100cyclin D3Homo sapiens
1082AAH115814280100BC011581 Similar to oxysterolHomo sapiens
binding protein
1082AF185696_14280100AF185696 oxysterol-bindingHomo sapiens
protein 1
1082AF1857054280100oxysterol binding protein 1Homo sapiens
1083AJ133816156636viral polypeptidePorcine
endogenous
retrovirus
1083D10032164537gag-pol precursor polyproteinBaboon
endogenous
virus strain
M7
1083M26927157136pol polyproteinGibbon ape
leukemia
virus
1084AF012920625100GEC-1Cavia
porcellus
1084AF312680625100GEC-1Cavia
porcellus
1084BC004602625100RIKEN cDNA 9130422N19 geneMus musculus
1085AAH142411733100BC014241 Similar to hypotheticalHomo sapiens
protein, MGC: 7035
1085AB093636168796hypothetical proteinMacaca
fascicularis
1085AK046512127474unnamed protein productMus musculus
1086AF140240_1749100AF140240 transcription factorHomo sapiens
TBX3
1086AK075457749100unnamed protein productHomo sapiens
1086BC025258749100T-box 3 (ulnar mammary syndrome)Homo sapiens
1087AK02504733168unnamed protein productHomo sapiens
1087AK02511633067unnamed protein productHomo sapiens
1087AK09051136572unnamed protein productHomo sapiens
1088AAH01863320100BC001863 hypoxia-inducibleHomo sapiens
protein 2
1088AF144755_1320100AF144755 hypoxia-inducibleHomo sapiens
protein 2
1088AX105363320100unnamed protein productHomo sapiens
1089AAH00718196598BC000718 Similar to dynamitinHomo sapiens
(dynactin complex 50 kD subunit)
1089AAH09468196598BC009468 dynactin 2 (p50)Homo sapiens
1089AAH14083196598BC014083 dynactin 2 (p50)Homo sapiens
1090AB0376692790100L-type amino acid transporter 2Homo sapiens
1090AF171669_12790100AF171669 glycoprotein-associatedHomo sapiens
amino acid transporter LAT2
1090Y18483277899SLC7A8 proteinHomo sapiens
1091AAH1690522862BC016905 Similar to hypotheticalHomo sapiens
protein PRO1722
1091AF118094_2126165AF118082 PRO1902Homo sapiens
1091AK09091320259unnamed protein productHomo sapiens
1092AK075392158899unnamed protein productHomo sapiens
1092AX136157158899unnamed protein productHomo sapiens
1092AX17929315919921676 ADHHomo sapiens
1093AAH13985242691BC013985 PC2 (positive cofactorHomo sapiens
2, multiprotein complex)
glutanine/Q-rich-associated
protein
1093AK090465267799FLJ00386 proteinHomo sapiens
1093BC017110267799Unknown (protein for MGC: 16010)Homo sapiens
1094AAH105142363100BC010514 clusterin (complementHomo sapiens
lysis inhibitor, SP-40,40,
sulfated glycoprotein 2,
testosterone-repressed prostate
message 2, apolipoprotein J)
1094AAH195882363100BC019588 clusterin (complementHomo sapiens
lysis inhibitor, SP-40,40,
sulfated glycoprotein 2,
testosterone-repressed prostate
message 2, apolipoprotein J)
1094X147232363100SP-40,40 prepropetide (AA −22 toHomo sapiens
427)
1095AAH067861161100BC006786 cellular repressor ofHomo sapiens
E1A-stimulated genes
1095AAH086281161100BC008628 cellular repressor ofHomo sapiens
E1A-stimulated genes
1095AF0845231161100cellular repressor of E1A-Homo sapiens
stimulated genes CREG
1096AX167114822099unnamed protein productHomo sapiens
1096BC036531820699Unknown (protein for MGC: 33668)Homo sapiens
1096Z74615822099prepro-alpha1 (I) collagenHomo sapiens
1097AB025412567198Ten-m3Mus musculus
1097AF195418_1567699AF195418 ODZ3Mus musculus
1097AK0013365447100unnamed protein productHomo sapiens
1098AAH035501419100BC003550 Similar to CGI-20Homo sapiens
protein
1098AF132954_1157799AF132954 CGI-20 proteinHomo sapiens
1098AK003551161395unnamed protein productMus musculus
1099BC02251224496platelet/endothelial cellHomo sapiens
adhesion molecule (CD31 antigen)
1099L3465724496platelet endothelial cellHomo sapiens
adhesion molecule-1
1099M2852624496PECAM-1 precursorHomo sapiens
1100AAH121381849100BC012138 Similar to guanineHomo sapiens
nucleotide binding protein (G
protein), alpha inhibiting
activity polypeptide 2
1100AF493906_11849100AF493906 guanine nucleotideHomo sapiens
binding protein alpha i2
1100X048281849100G protein alpha-subunit (AA 1-355)Homo sapiens
1101AF081258_13091100AF081258 testis-specificHomo sapiens
chromodomain Y-like protein
1101AF081259_13091100AF081259 testis-specificHomo sapiens
chromodomain Y-like protein
1101AF081261_1261488AF081261 testis-specificMus musculus
chromodomain Y-like protein
1102AF162856_1514765AF162856 receptor-like proteinMus musculus
tyrosine phosphatase rho-1
1102X58287756997protein-tyrosine phosphataseMus musculus
1102X58288773199protein-tyrosine phosphataseHomo sapiens
1103AK09796533074unnamed protein productHomo sapiens
1103AX40000831969unnamed protein productHomo sapiens
1103BC03395936279similar to Alu subfamily SQHomo sapiens
sequence contamination warning
entry
1104AAH189911272100BC018991 hepatoma-derived growthHomo sapiens
factor (high-mobility group
protein 1-like)
1104AJ237996120595hepatoma derived growth factorBos taurus
1104D164311272100hepatoma-derived GFHomo sapiens
1105AAH17197178599BC017197 myeloid cell leukemiaHomo sapiens
sequence 1 (BCL2-related)
1105AF147742_1178599AF147742 myeloid cellHomo sapiens
differentiation protein
1105AF162677178599myeloid cell leukemia protein 1Homo sapiens
1106AF2748922520100glucose transporter 3Homo sapiens
1106BC0391962520100solute carrier family 2Homo sapiens
(facilitated glucose
transporter), member 3
1106M206812520100glucose transporter-like proteinHomo sapiens
1107AAH007303448100BC000730 calpain 6Homo sapiens
1107AJ000388343999calpain-like protease, CANPXHomo sapiens
1107AL0311173448100dJ914P14.1 (calpain-like proteaseHomo sapiens
CANPX)
1108AAH031431980100BC003143 dual specificityHomo sapiens
phosphatase 6
1108AAH035621980100BC003562 dual specificityHomo sapiens
phosphatase 6
1108X939201980100protein-tyrosine-phosphataseHomo sapiens
1109AB0231946006100KIAA0977 proteinHomo sapiens
1109AK052533354961unnamed protein productMus musculus
1109AL049939182399hypothetical proteinHomo sapiens
1110AAH150314447100BC015031 Unknown (protein forHomo sapiens
MGC: 9105)
1110AB0182664447100KIAA0723 proteinHomo sapiens
1110BC029070437598Similar to matrin 3Mus musculus
1111AAH187261229100BC018726 CD74 antigen (invariantHomo sapiens
polypeptide of major
histocompatibility complex, class
II antigen-associated)
1111M135601229100cell surface glycoproteinHomo sapiens
1111X004971229100putative p33Homo sapiens
1112AF114262_3230588AF114260 forkhead protein AFXHMus musculus
1112X939962624100AFXHomo sapiens
1112Y11284248997AFX1Homo sapiens
1113AAH094091688100BC009409 Unknown (protein forHomo sapiens
MGC: 10655)
1113X134251688100GA733-1 protein (AA 1-323)Homo sapiens
1113X777541688100gp50/TROP-2Homo sapiens
1114AAH02532795100BC002532 epididymal secretoryHomo sapiens
protein (19.5 kD)
1114X67698795100orfHomo sapiens
1114X78134795100epididymal secretory protein 14.6Macaca
fascicularis
1115AK075092233100unnamed protein productHomo sapiens
1116AAH166921163100BC016692 progesterone receptorHomo sapiens
membrane component 2
1116AJ0020301163100progresterone binding proteinHomo sapiens
1116AY06992152560membrane progesterone receptor-Oncorhynchus
like proteinmykiss
1117AAH160411441100BC016041 insulin-like growthHomo sapiens
factor-binding protein 4
1117M624031441100IGF-BP 4Homo sapiens
1117Y125081441100insulin-like growth factorHomo sapiens
binding protein 4
1118AK000575734100unnamed protein productHomo sapiens
1118AK01343848472unnamed protein productMus musculus
1118AY116892734100HCF-1 beta-propeller interactingHomo sapiens
protein
1119AAH144102710100BC014410 Similar to EGF-Homo sapiens
containing fibulin-like
extracellular matrix protein 1
1119AK077302258194unnamed protein productMus musculus
1119AY0043302710100EGF-containing fibulin-likeHomo sapiens
extracellular matrix protein 1
1120AF1025521106684270 kDa ankyrin G isoformRattus
norvegicus
1120L40632718495ankyrin 3Mus musculus
1120U136162010799ankyrin GHomo sapiens
1121AC0020733406100Lim KinaseHomo sapiens
1121AL1174663183100hypothetical proteinHomo sapiens
1121D459063406100LIMK-2Homo sapiens
1122AAH00836633100BC000836 CGI-127 proteinHomo sapiens
1122AF135161_1633100AF135161 unknownHomo sapiens
1122AF151885_1633100AF151885 CGI-127 proteinHomo sapiens
1123A1676835679kunitz type protease inhibitorsynthetic
construct
1123BC03317450198Similar to collagen, type VI,Homo sapiens
alpha 3
1123X5202250198collagen type VI, alpha 3 chainHomo sapiens
1124AAH04440776100BC004440 Unknown (protein forHomo sapiens
MGC: 4033)
1124AAH19336821100BC019336 Unknown (protein forHomo sapiens
IMAGE: 3617778)
1124U9151277099ninjurinHomo sapiens
1125AAH18127125093BC018127 Similar toHomo sapiens
Peptidylglycine alpha-amidating
monooxygenase
1125AB095007125093peptidylglycine alpha-amidatingHomo sapiens
monooxygenase
1125AF0353201279100peptidylglycine alpha-amidatingHomo sapiens
monooxygenase
1126AAH133986167100BC013398 pumilio (Drosophila)Homo sapiens
1126AF315592_16167100AF315592 Pumilio 1Homo sapiens
1126D439516233100KIAA0099 proteinHomo sapiens
1127AAH00465826100BC000465 growth arrest and DNA-Homo sapiens
damage-inducible, gamma
1127AAH19325826100BC019325 growth arrest and DNA-Homo sapiens
damage-inducible, gamma
1127AF494037_1826100AF494037 growth arrest and DNA-Homo sapiens
damage-inducible, gamma
1128AAH01955883100BC001955 ribosomal protein S10Homo sapiens
1128AAH04334883100BC004334 ribosomal protein S10Homo sapiens
1128AAH05012883100BC005012 ribosomal protein S10Homo sapiens
1129AAH12740468799BC012740 Similar to dystroglycanHomo sapiens
1 (dystrophin-associated
glycoprotein 1)
1129AAH14616468799BC014616 Unknown (protein forHomo sapiens
MGC: 3618)
1129L197114703100dystroglycanHomo sapiens
1130AAH20983978100BC020983 pituitary tumor-Homo sapiens
transforming 1 interacting
protein
1130BC031097978100pituitary tumor-transforming 1Homo sapiens
interacting protein
1130BC034250978100pituitary tumor-transforming 1Homo sapiens
interacting protein
1131AAH07082185100BC007082 SWI/SNF related, matrixHomo sapiens
associated, actin dependent
regulator of chromatin, subfamily
e, member 1
1131AAH11017185100BC011017 SWI/SNF related, matrixHomo sapiens
associated, actin dependent
regulator of chromatin, subfamily
e, member 1
1131AF035262185100BAF57Homo sapiens
1133AF0991541365686von Willebrand factorCanis
familiaris
1133M258651551099von Willebrand factorHomo sapiens
1133X0438515515100VWF pre-pro-polypeptide (−22 toHomo sapiens
2791)
1134AAH17692314399BC017692 Similar to quiescin Q6Homo sapiens
1134AF361868313598sulfhydryl oxidaseHomo sapiens
1134U97276391199quiescinHomo sapiens
1136AAH121231528100BC012123 golgi phosphoprotein 3Homo sapiens
1136AJ2961521528100Golgi proteinHomo sapiens
1136BC0337251528100golgi phosphoprotein 3 (coat-Homo sapiens
protein)
1137AAH087262687100BC008726 oxidative-stressHomo sapiens
responsive 1
1137AB0176422687100oxidative-stress responsive 1Homo sapiens
1137AB0290242355100KIAA1101 proteinHomo sapiens
1138AAH00478340399BC000478 heat shock 70 kD proteinHomo sapiens
9B (mortalin-2)
1138BC024034340399heat shock 70 kD protein 9BHomo sapiens
(mortalin-2)
1138BC030634339999heat shock 70 kD protein 9BHomo sapiens
(mortalin-2)
1139BC006834892100B-cell translocation gene 1,Mus musculus
anti-proliferative
1139BC018309892100B-cell translocation gene 1,Mus musculus
anti-proliferative
1139Z16410892100btg1Mus musculus
1140AK07572051792unnamed protein productMus musculus
1140BC00386251792Similar to transmembrane 9Mus musculus
superfamily member 2
1140U8100651893p76Homo sapiens
1141A037363879100factor XIIIaHomo sapiens
1141M143543879100clotting factor XIIIa precursorHomo sapiens
(EC 2.3.2.13)
1141M14539401699factor XIII precursorHomo sapiens
1142AAH0654196999BC006541 integrin, beta 5Homo sapiens
1142J0563396298integrin beta-5 subunit precursorHomo sapiens
1142X5300296999precusor polypeptide (AA −23 toHomo sapiens
776)
1143D509297262100The KIAA0139 gene product isHomo sapiens
related to mouse centrosomin B.
1143U580467262100p167Homo sapiens
1143U783117262100translation initiation factor 3Homo sapiens
large subunit
1144AAH01571470899BC001571 eukaryotic translationHomo sapiens
initiation factor 3, subunit 8
(110 kD)
1144AC002544470899Translation initiation factorHomo sapiens
eIF-p110
1144U46025470899translation intiation factor eIF-3Homo sapiens
p110 subunit
1145AB019987651399chromosome-associatedHomo sapiens
polypeptide-C
1145AF092564604199chromosome-associated protein-CHomo sapiens
1145AL1368776517100hypothetical proteinHomo sapiens
1146AAH01756288099BC001756 phosphoglucomutase 1Homo sapiens
1146AAH19920287399BC019920 Unknown (protein forHomo sapiens
MGC: 29909)
1146M83088288099PGM1Homo sapiens
1147AB0206643759100KIAA0857 proteinHomo sapiens
1147AF334812_13333100AF334812 Rab11 interactingHomo sapiens
protein Rip11a
1147BC035013330399Similar to Rab coupling proteinHomo sapiens
1148AF356518_11637100AF356518 junctional adhesionHomo sapiens
molecule 3 precursor
1148AF448478_11637100AF448478 junctional adhesionalHomo sapiens
molecule-3
1148AJ4161011870100junction adhesion molecule 3Homo sapiens
1149AF130117_4835577AF130089 PRO2550Homo sapiens
1149AK00038535374unnamed protein productHomo sapiens
1149AK09726632479unnamed protein productHomo sapiens
1150AAH015623284100BC001562 nuclear receptorHomo sapiens
coactivator 4
1150AL1620473284100hypothetical proteinHomo sapiens
1150L493993284100ORFHomo sapiens
1151AAH023562379100B0002356 nucleobindin 1Homo sapiens
1151M96824232698nucleobindinHomo sapiens
1151U31342235799nucleobindinHomo sapiens
1152AAH171804694100BC017180 Unknown (protein forHomo sapiens
MGC: 790)
1152AK088028459797unnamed protein productMus musculus
1152BC007126459797Unknown (protein for MGC: 5677)Mus musculus
1153AAH08099378100BC008099 Unknown (protein forHomo sapiens
IMAGE: 4183312)
1154AF137053_1231099AF137053 mutant desminHomo sapiens
1154BC032116231399desminHomo sapiens
1154U591672325100desminHomo sapiens
1155AL4457952337699heparan sulfate proteoglycanHomo sapiens
perlecan
1155M852892347799heparan sulfate proteoglycanHomo sapiens
1155X625152362799Human basement membrane heparanHomo sapiens
sulfate proteoglycan core protein
1156AK05783027051unnamed protein productHomo sapiens
1156BC02465121058similar to PRO2550Homo sapiens
1156BC03201923055similar to Alu subfamily SQHomo sapiens
sequence contamination warning
entry
1157AAH00429309100BC000429 chromosome 14 openHomo sapiens
reading frame 2
1157AAH01944309100BC001944 chromosome 14 openHomo sapiens
reading frame 2
1157AF054175309100mitochondrial proteolipid 68MPHomo sapiens
homolog
1158AAH012632152100BC001263 serum/glucocorticoidHomo sapiens
regulated kinase
1158AF153609_12152100AF153609 serine/threonine proteinHomo sapiens
kinase sgk
1158AX5535492152100unnamed protein productHomo sapiens
1159AAH07103710100BC007103 small acidic proteinHomo sapiens
1159AAH16352710100BC016352 small acidic proteinHomo sapiens
1159AAH20937710100BC020937 small acidic proteinHomo sapiens
1161AY043487412100selenoprotein SelMHomo sapiens
1161AY04348836785selenoprotein SelMMus musculus
1161BC01974234585Unknown (protein for MGC: 30803)Mus musculus
1162AF124719_11018100AF124719 GM2 activator proteinHomo sapiens
1162X61095103997GM2-activator proteinHomo sapiens
1162X620781018100GM2 activator proteinHomo sapiens
1163AB0289741802100KIAA1051 proteinHomo sapiens
1163AB0491501703100MEF3 like 1Homo sapiens
1163AX0826222129100unnamed protein productHomo sapiens
1164BC0266903964100CD97 antigenHomo sapiens
1164U76764379687CD97Homo sapiens
1164X84700395199leucocyte antigen CD97Homo sapiens
1165K03195248599glucose transporter glycoproteinHomo sapiens
1165M13979243097glucose-transporter proteinRattus
norvegicus
1165M22063243097glucose transporter proteinRattus
norvegicus
1166AAH192971801100BC019297 Unknown (protein forHomo sapiens
MGC: 4111)
1166AK0216551801100unnamed protein productHomo sapiens
1166AK0227571801100unnamed protein productHomo sapiens
1167AC0059431522100methyl-CpG binding protein MBD3Homo sapiens
1167AF0722471522100methyl-CpG binding domain-Homo sapiens
containing protein MBD3
1167AF072248142795methyl-CpG binding domain-Mus musculus
containing protein MBD3
1168AB0180092602100L-type amino acid transporter 1Homo sapiens
1168AB0185422602100CD98 light chainHomo sapiens
1168AF1040322602100L-type amino acid transporterHomo sapiens
subunit LAT1
1170AAH107371911100BC010737 Similar to reticulon 4Homo sapiens
1170AAH126191911100BC012619 Unknown (protein forHomo sapiens
MGC: 13655)
1170BC0267881911100reticulon 4Homo sapiens
1171AAH02412376699BC002412 inner membrane protein,Homo sapiens
mitochondrial (mitofilin)
1171D21094376699motor proteinHomo sapiens
1171L425723771100transmembrane proteinHomo sapiens
1172AAH01925573100BC001925 FK506-binding protein 1AHomo sapiens
(12 kD)
1172AAH05147573100BC005147 FK506-binding protein 1AHomo sapiens
(12 kD)
1172M93060573100FK506-binding protein 12Homo sapiens
1173AF116721_20391100AF116620 PRO1068Homo sapiens
1174AK075023133599unnamed protein productHomo sapiens
1174AL1174421344100hypothetical proteinHomo sapiens
1174BC002138130296Unknown (protein forMus musculus
IMAGE: 3484538)
1175AAH07674382100BC007674 CD24 antigen (small cellHomo sapiens
lung carcinoma cluster 4 antigen)
1175L33930382100signal transducer CD24Homo sapiens
1175M58664382100signal transducer CD24Homo sapiens
1176AAH121814260100BC012181 Similar to paired basicHomo sapiens
amino acid cleaving enzyme
(furin, membrane associated
receptor protein)
1176U20436406095furin endoproteaseCricetulus
griseus
1176X170944260100furin (AA 1-794)Homo sapiens
1177AAH152361189100BC015236 hypothetical proteinHomo sapiens
1177AF335324_11189100AF335324 RTP801Homo sapiens
1177AY0900971189100REDD-1Homo sapiens
1178AK02680028972unnamed protein productHomo sapiens
1178AK05783036469unnamed protein productHomo sapiens
1178BC03201933070similar to Alu subfamily SQHomo sapiens
sequence contamination warning
entry
1179AAH100583813100BC010058 exostoses (multiple) 2Homo sapiens
1179U627403813100EXT2Homo sapiens
1179U673683813100multiple exostosis 2Homo sapiens
1180AAH083011967100BC008301 tuftelin 1Homo sapiens
1180AF254260_11967100AF254260 tuftelin 1Homo sapiens
1180AF2548601967100tuftelin 1Homo sapiens
1182AF272662_1976494AF272662 alpha 1 type V collagenRattus
norvegicus
1182D902791031199collagen alpha 1(V) chainHomo sapiens
precursor
1182M767291027799pro-alpha-1 type V collagenHomo sapiens
1183AAH03155147590BC003155 coatomer proteinHomo sapiens
complex, subunit epsilon
1183AAH07250147590BC007250 coatomer proteinHomo sapiens
complex, subunit epsilon
1183AAH17285147590BC017285 Unknown (protein forHomo sapiens
MGC: 29652)
1184AX354381347100unnamed protein productHomo sapiens
1185AF202636_12164100AF202636 angiopoietin-likeHomo sapiens
protein PP1158
1185AX0799712164100unnamed protein productHomo sapiens
1185BC0236472164100angiopoietin-like 4Homo sapiens
1186AK0567671189100unnamed protein productHomo sapiens
1186AL83191371385hypothetical proteinHomo sapiens
1187AAH012701896100BC001270 SM3-domain GRB2-like 1Homo sapiens
1187U659991896100SH3-containing protein EENHomo sapiens
1187X996561896100SH3-containing Grb-2-like 1Homo sapiens
1188AAH003854505100BC000385 Unknown (protein forHomo sapiens
MGC: 8429)
1188AF1028034505100alphaE-cateninHomo sapiens
1188D138664505100alpha-cateninHomo sapiens
1189AAH0756460790BC007564 annexin A11Homo sapiens
1189AJ27846460790annexin A11Homo sapiens
1189AJ27846560790annexin A11Homo sapiens
1190AAH01491147099BC001491 heme oxygenaseHomo sapiens
(decycling) 1
1190X069851475100heme oxygenase (AA 1-288)Homo sapiens
1190Z822441475100bK286B10.2 (Heme OxygenaseHomo sapiens
(decycling) 1 (HO-1 EC
1.14.99.3))
1192AAH139101671100BC013910 Similar to deathHomo sapiens
effector domain-containing
1192AAH167241671100BC016724 death effector domain-Homo sapiens
containing
1192AJ0109731671100DEDD proteinHomo sapiens
1193AAH178821276100BC017882 proteasome (prosome,Homo sapiens
macropain) subunit, alpha type 6
1193BC0223541276100proteasome (prosome, macropain)Homo sapiens
subunit, alpha type 6
1193D107551276100proteasome subunit R-IOTARattus sp.
1194AAH095812041100BC009581 hydroxysteroid (17-beta)Homo sapiens
dehydrogenase 2
1194L11708204110017 beta hydroxysteroidHomo sapiens
dehydrogenase type 2
1194L40802204110017-hydroxysteroid dehydrogenaseHomo sapiens
1195AAH08452586100BC008452 ATPase, H+ transporting,Homo sapiens
lysosomal (vacuolar proton pump),
member J
1195AP038954586100vacuolar H(+)-ATPase subunitHomo sapiens
1195S8246457396vacuolar H(+)-ATPase subunit; V-Bos taurus
ATPase subunit; M16
1196AE00345219335CG9350-PBDrosophila
melanogaster
1196AJ51014857172mitochondrial NADH: ubiquinoneBos taurus
oxidoreductase B14.7 subunit
1196AK00820153265unnamed protein productMus musculus
1197AB0206853216100KIAA0878 proteinHomo sapiens
1197AK006650206593unnamed protein productMus musculus
1197BC041337321299Rho-related BTB domain containing 3Homo sapiens
1198AB0587491868100KIAA1846 proteinHomo sapiens
1198AK0922951868100unnamed protein productHomo sapiens
1198AL0356611868100dJ568C11.3 (novel AMP-bindingHomo sapiens
enzyme similar to acetyl-coenzyme
A synthethase (acetate-coA
ligase))
1199AF0092421163100proline-rich Gla protein 1Homo sapiens
1199AF41915457252mitotic phosphoprotein 77Xenopus
laevis
1199BC0307861246100proline-rich Gla (G-Homo sapiens
carboxyglutamic acid) polypeptide 1
1200AF000652150399synteninHomo sapiens
1200AF0066361508100melanoma differentiationHomo sapiens
associated protein-9
1200U83463150399scaffold protein Pbp1Homo sapiens
1201AF312032520099ephrin type-B receptor 4Homo sapiens
precursor
1201AY056047520099receptor protein tyrosine kinaseHomo sapiens
EphB4
1201U07695519699tyrosine kinaseHomo sapiens
1202AF015553495599TFII-I proteinHomo sapiens
1202AF038969494999general transcription factor 2-IHomo sapiens
1202Y14946494999SPIN proteinHomo sapiens
1203AAH074521442100BC007452 Similar to WW domainHomo sapiens
binding protein 2
1203AAH106161442100BC010616 Unknown (protein forHomo sapiens
MGC: 18269)
1203U794581458100WW domain binding protein-2Homo sapiens
1204AB097511399693hypothetical proteinMacaca
fascicularis
1204AL359292737399dJ448K1.1.1 (absent in melanomaHomo sapiens
1, isoform 1)
1204U831158577100non-lens beta gamma-crystallinHomo sapiens
like protein
1205AAH0592158987BC005921 chorionicHomo sapiens
somatomammotropin hormone 1
(placental lactogen)
1205AAH2075658987BC020756 chorionicHomo sapiens
somatomammotropin hormone 1
(placental lactogen)
1205AAH2204458987BC022044 chorionicHomo sapiens
somatomammotropin hormone 2
1206AY158924650100histone protein Hist2h2aa2Mus musculus
1206AY158925650100histone protein Hist2h2aa1Mus musculus
1206AY158953650100histone protein Hist2h3c2Mus musculus
1207AF226614_12929100AF226614 ferroportin1Homo sapiens
1207AF231121_12929100AF231121 iron-regulatedHomo sapiens
transporter IREG1
1207BC0377332929100solute carrier family 11 (proton-Homo sapiens
coupled divalent metal ion
transporters), member 3
1208AAH01693709100BC001693 lectin, galactoside-Homo sapiens
binding, soluble, 1 (galectin 1)
1208AAH20675709100BC020675 lectin, galactoside-Homo sapiens
binding, soluble, 1 (galectin 1)
1208X14829709100beta-galactoside-binding lectinHomo sapiens
(AA 1-135)
1209AF151794167838pol proteinPhascolarctos
cinereus
1209AY099324167138gag-pol polyproteinporcine
endogenous
retrovirus B
1209M26927171738pol polyproteinGibbon ape
leukemia
virus
1210AAD1807668999AF129756 G6cHomo sapiens
1210AJ01200868999Ly6-C proteinHomo sapiens
1210AJ31553368999LY6G6C proteinHomo sapiens
1211AAH116822559100BC011682 Similar to cathepsin FHomo sapiens
1211AF132894_12559100AF132894 cathepsin FHomo sapiens
1211AJ0073312559100cysteine proteinaseHomo sapiens
1212AF247565_151397AF247565 anaphase promotingHomo sapiens
complex subunit 11
1212AF247789_151397AF247789 putative anaphase-Homo sapiens
promoting complex subunit APC11
1212AX06162251397unnamed protein productHomo sapiens
1213AAH1181155992BC011811 Unknown (protein forHomo sapiens
MGC: 20260)
1213AF218016_143276AF218016 unknownHomo sapiens
1214AAH1720168092BC017201 insulin-like growthHomo sapiens
factor binding protein 7
1214L1918268092MAC25Homo sapiens
1214S7572568092prostacyclin-stimulating factor;Homo sapiens
PGI2-stimulating factor; PSF
1215AAH0059025071BC000590 actin related proteinHomo sapiens
2/3 complex, subunit 2 (34 kD)
1215AP00608525071p34-ArcHomo sapiens
1215U5052325071unknownHomo sapiens
1216AF126110_171896AF126110 fibulin-1 isoform DHomo sapiens
precursor
1216AF217999_171896AF217999 unknownHomo sapiens
1216BC02249771896fibulin 1Homo sapiens
1217AAH0583950297BC005839 follistatin-like 3Homo sapiens
(secreted glycoprotein)
1217BC03311950297follistatin-like 3 (secretedHomo sapiens
glycoprotein)
1217U7670250297follistatin-related protein FLRGHomo sapiens
1218AAH0016360199BC000163 vimentinHomo sapiens
1218BC03057360199Unknown (protein for MGC: 16183)Homo sapiens
1218X5613460199vimentinHomo sapiens
1219AB0182655555100KIAA0722 proteinHomo sapiens
1219AF0454585460100serine/threonine kinase ULK1Homo sapiens
1219AF072370_1486589AF072370 UNC51.1 serine/threonineMus musculus
kinase
1220AAH00865227100BC000865 Unknown (protein forHomo sapiens
IMAGE: 3460093)
1221AAH0297827991BC002978 CD81 antigen (target ofHomo sapiens
antiproliferative antibody 1)
1221AF11660027991CD81Pan
troglodytes
1221M336802799126-kDa cell surface protein TAPA-1Homo sapiens
1222AAH15156678100BC015156 ferritin, heavyHomo sapiens
polypeptide 1
1222AAH16009678100BC016009 ferritin, heavyHomo sapiens
polypeptide 1
1222AAH16857678100BC016857 ferritin, heavyHomo sapiens
polypeptide 1
1223AAH08012518100BC008012 eukaryotic translationHomo sapiens
elongation factor 1 delta
(guanine nucleotide exchange
protein)
1223AAH09907518100BC009907 eukaryotic translationHomo sapiens
elongation factor 1 delta
(guanine nucleotide exchange
protein)
1223AAH12819518100BC012819 eukaryotic translationHomo sapiens
elongation factor 1 delta
(guanine nucleotide exchange
protein)
1224AAH0592155683BC005921 chorionicHomo sapiens
somatomammotropin hormone 1
(placental lactogen)
1224AAH2075655683BC020756 chorionicHomo sapiens
somatomammotropin hormone 1
(placental lactogen)
1224AAH2204455683BC022044 chorionicHomo sapiens
somatomammotropin hormone 2
1225A65264705100unnamed protein productunidentified
1225AAH0128857493BC001288 Similar to decayHomo sapiens
accelerating factor for
complement (CD55, Cromer blood
group system)
1225AF149760_157493AF149760 decay-acceleratingPan
factortroglodytes
1226AK02221719176unnamed protein productHomo sapiens
1226AK05673419172unnamed protein productHomo sapiens
1226AK09734220978unnamed protein productHomo sapiens
1227AAH0532649998BC005326 ribosomal protein L27aHomo sapiens
1227AAH2016949998BC020169 Unknown (protein forHomo sapiens
IMAGE: 3543815)
1227U1496849998ribosomal protein L27aHomo sapiens
1229AAH2129756994BC021297 Similar to Dynein heavyHomo sapiens
chain 64C
1229AB00232356994KIAA0325Homo sapiens
1229AY00487753989cytoplasmic dynein heavy chainMus musculus
1230BC026018643100Similar to laminin, beta 1Homo sapiens
1230M20206643100laminin B1Homo sapiens
1230M55370643100laminin B1Homo sapiens
1231AF06165859191cytidine deaminaseHomo sapiens
1231AJ00047459191cytidine deaminaseHomo sapiens
1231L2794359191cytidine deaminaseHomo sapiens
1232AAH1898648683BC018986 Unknown (protein forHomo sapiens
MGC: 20092)
1232AF22983048683prostaglandin dehydrogenasePapio
hamadryas
1232U632964868315-hydroxyprostaglandinHomo sapiens
dehydrogenase
1233AAH00749507100BC000749 lactate dehydrogenase AHomo sapiens
1233AAH01829507100BC001829 lactate dehydrogenase AHomo sapiens
1233X03077507100lactate dehydrogenase-AHomo sapiens
1234AAH0090379188BC000903 high-mobility groupHomo sapiens
(nonhistone chromosomal) protein 2
1234AAH0106379188BC001063 high-mobility groupHomo sapiens
(nonhistone chromosomal) protein 2
1234X6253479188HMG-2Homo sapiens
1235AF193055_159488AF193055 unknownHomo sapiens
1235AK07521459488unnamed protein productHomo sapiens
1235BC03858759488Similar to EGF-like-domain,Homo sapiens
multiple 6
1236AF13506063296fibrillin-2Rattus
norvegicus
1236U0327263799fibrillin-2Homo sapiens
1236X6200963798fibrillin 5Homo sapiens
1237AAH13083522100BC013083 Similar to cystatin CHomo sapiens
(amyloid angiopathy and cerebral
hemorrhage)
1237X12763522100ompA —cystatin C fusionsynthetic
preprotein (AA −21 to 120)construct
1237X61681522100cystatin CHomo sapiens
1239AF13506052389fibrillin-2Rattus
norvegicus
1239L3979053290fibrillin 2Mus musculus
1239U03272597100fibrillin-2Homo sapiens
1240M65149120085CELFRattus
norvegicus
1240M836671430100NF-IL6-beta proteinHomo sapiens
1240S63168141899CCAAT/enhancer-binding proteinHomo sapiens
delta; C/EBP delta
1241AF186111_123052AF186111 NOTCH4-like proteinHomo sapiens
1241AL51273523052hypothetical proteinHomo sapiens
1241AX13383123052unnamed protein productHomo sapiens
1242BC01530266487lamin AMus musculus
1242M1345271595lamin A proteinHomo sapiens
1242X7629767088lamin ARattus
norvegicus
1244AB049946666100mitochondrial ribosomal proteinHomo sapiens
S15
1244BC02919343369mitochondrial ribosomal proteinMus musculus
S15
1244BC031336666100mitochondrial ribosomal proteinHomo sapiens
S15
1245AAH1373339293BC013733 px19-like proteinHomo sapiens
1245AAH1374839293BC013748 px19-like proteinHomo sapiens
1245AF201925_139293AF201925 PRELIHomo sapiens
1246AAH02362694100BC002362 lactate dehydrogenase BHomo sapiens
1246AAH15122694100BC015122 lactate dehydrogenase BHomo sapiens
1246Y00711694100lactate dehydrogenase B (AA 1-334)Homo sapiens
1247AAH0307050486BC003070 GATA-binding protein 3Homo sapiens
1247AAH0679350486BC006793 GATA-binding protein 3Homo sapiens
1247X5503750486GATA-3Homo sapiens
1248AF269289_1357100AF269289 unknownHomo sapiens
1249AAH0772854686BC007728 Unknown (protein forHomo sapiens
MGC: 12671)
1249AL08010254686hypothetical proteinHomo sapiens
1249U4943654686translation initiation factor 5Homo sapiens
1250AAH0319047294BC003190 p75NTR-associated cellHomo sapiens
death executor; ovarian granulosa
cell protein (13 kD)
1250AF187064_147294AF187064 p75NTR-associated cellHomo sapiens
death executor; NADE
1250M3818847294unknownHomo sapiens
1251AB037767542799KIAA1346 proteinHomo sapiens
1251AF207664_15274100AF207664 matrix metalloproteaseHomo sapiens
1251AP0016975274100metalloprotease withHomo sapiens
thrombospondin type 1 motifs
1252U9093822276Fc gamma receptor IIc1Homo sapiens
1252X1765222276IgG Fc receptorHomo sapiens
1252X1765222276IgG Fc receptorHomo sapiens
1253AAH0176839093BC001768 neuronatinHomo sapiens
1253AL10961439093bA425M5.3.1 (neuronatin (isoformHomo sapiens
1))
1253U3176739093neuronatin alphaHomo sapiens
1254AF151373_154275AF151373 nucleolin-relatedRattus
protein NRPnorvegicus
1254AK09174267096unnamed protein productHomo sapiens
1254M6085867096nucleolinHomo sapiens
1255AAH1342861693BC013428 PP1201 proteinHomo sapiens
1255AF193045_161693AF193045 unknownHomo sapiens
1255BC02634861693PP1201 proteinHomo sapiens
1256AF393832_176599AF393832 beta-actinMorulius
calbasu
1256AY03965776599beta-actinChrysophrys
auratus
1256AY14835076599actinDicentrarchus
labrax
1257AK055593379100unnamed protein productHomo sapiens
1258AAH212331036100BC021233 ATP synthase, H+Homo sapiens
transporting, mitochondrial F1
complex, O subunit (oligomycin
sensitivity conferring protein)
1258BC0228651036100ATP synthase, H+ transporting,Homo sapiens
mitochondrial F1 complex, O
subunit (oligomycin sensitivity
conferring protein)
1258X832181036100ATP synthase, oligomycinHomo sapiens
sensitivity conferring protein
1259AAH04368122199BC004368 proteasome (prosome,Homo sapiens
macropain) activator subunit 2
(PA28 beta)
1259AAH19885122199BC019885 proteasome (prosome,Homo sapiens
macropain) activator subunit 2
(PA28 beta)
1259D452481226100proteasome activator hPA28 suunitHomo sapiens
beta
1260AF0903062306100retinoblastoma binding proteinRattus
norvegicus
1260U351432306100retinoblastoma-binding proteinHomo sapiens
RbAp46
1260X728412306100IEF 7442Homo sapiens
1261AAH004131748100BC000413 eukaryotic translationHomo sapiens
initiation factor 3, subunit 2
(beta, 36 kD)
1261AAH031401748100BC003140 eukaryotic translationHomo sapiens
initiation factor 3, subunit 2
(beta, 36 kD)
1261U390671748100translation initiation factorHomo sapiens
eIF3 p36 subunit
1262AF04216613721100beta-filaminHomo sapiens
1262AF0430451370999actin-binding protein homologHomo sapiens
ABP-278
1262AF19163313721100filaminHomo sapiens
1263AF165515_11862100AF165515 ancient ubiquitousHomo sapiens
protein 1 precursor
1263AK0239831935100unnamed protein productHomo sapiens
1263BC0336461862100ancient ubiquitous protein 1Homo sapiens
1264AB0098651347100Angiopoietin-2Homo sapiens
1264AF187858_1133599AF187858 angiopoietin-2 isoform-1Homo sapiens
1264AF218015_11347100AF218015 unknownHomo sapiens
1265AF03571891499mesoderm-specific basic-helix-Homo sapiens
loop-helix protein; Pod-1
1265AL356109917100bA373A10.1 (transcription factorHomo sapiens
21)
1265BC025697917100transcription factor 21Homo sapiens
1266M386901200100CD9 antigenHomo sapiens
1266S604891200100CD9 antigenHomo sapiens
1266X601111200100MRP-1 (motility related protein)Homo sapiens
1267AAH02368462999BC002368 proteasome (prosome,Homo sapiens
macropain) 26S subunit, non-
ATPase, 2
1267AAH02997462999BC002997 proteasome (prosome,Homo sapiens
macropain) 26S subunit, non-
ATPase, 2
1267D781514637100human 26S proteasome subunit p97Homo sapiens
1268AAH001821622100BC000182 annexin A4Homo sapiens
1268AAH116591622100BC011659 Similar to annexin A4Homo sapiens
1268D781521622100annexin IV (carbohydrtate-bindingHomo sapiens
protein p33/41)
1269AAH03064401699BC003064 disabled (Drosophila)Homo sapiens
homolog 2 (mitogen-responsive
phosphoprotein)
1269AF2058904028100disabled-2Homo sapiens
1269U390504028100DOC-2Homo sapiens
1270AAH07075780100BC007075 hemoglobin, betaHomo sapiens
1270U01317780100beta-globinHomo sapiens
1270V00499780100beta globinHomo sapiens
1271AAH21557409399BC021557 transmembrane protein 8Homo sapiens
(five membrane-spanning domains)
1271AB0452924100100M83 proteinHomo sapiens
1271AE006463_7408899AE006463 M83Homo sapiens
1272AF193048_1946100AF193048 unknownHomo sapiens
1273AF151980_12009100AF151980 connexin 43Homo sapiens
1273BC0263292009100gap junction protein, alpha 1,Homo sapiens
43 kD (connexin 43)
1273X529472009100gap junction protein (AA 1-382)Homo sapiens
1274AJ3134631258100adipsin/complement factor DHomo sapiens
precursor
1274BC0345291249100Unknown (protein forHomo sapiens
IMAGE: 4780594)
1274M84526119898adipsin/complement factor DHomo sapiens
1275AF258549_1533100AF258549 PP1292Homo sapiens
1276AF217963_1421599AF217963 NRAGEHomo sapiens
1276AF258554_14223100AF258554 PP2250Homo sapiens
1276BC0324734223100melanoma antigen, family D, 1Homo sapiens
1277AAH14635635100BC014635 Similar to SH3-domain,Homo sapiens
GRB2-like, endophilin B2
1277AF257319_1635100AF257319 SH3-containing proteinHomo sapiens
SH3GLB2
1277AF258589_1635100AF258589 PP578Homo sapiens
1278AAH03390707100BC003390 hypothetical proteinHomo sapiens
1278AAH14334707100BC014334 Unknown (protein forHomo sapiens
MGC: 22874)
1278AF275807_1822100AF275807 PNAS-110Homo sapiens
1279AAH05238469100BC005238 FXYD domain-containingHomo sapiens
ion transport regulator 3
1279U282494117511 kD proteinHomo sapiens
1279X93036469100MAT8 proteinHomo sapiens
1280AF0144021500100type-2 phosphatidic acidHomo sapiens
phosphatase alpha-1
1280BC0398471500100Similar to phosphatidic acidHomo sapiens
phosphatase type 2A
1280Y144361500100phosphatidic acid phosphataseHomo sapiens
type 2
1281AL163249272999T-complex protein 1 theta subunitHomo sapiens
1281D13627273099KIAA0002Homo sapiens
1281D420522734100predicted protein of 548 aminoHomo sapiens
acids
1282AAH013122306100BC001312 protein disulfideHomo sapiens
isomerase-related protein
1282BC006865222095Similar to protein disulfideMus musculus
isomerase-related protein
1283D494892306100human P5Homo sapiens
1283AF439513_1791791AF439513 pregnancy-associatedMus musculus
plasma protein-A
1283U287278980100pregnancy-associated plasmaHomo sapiens
protein-A preproform
1283X682808574100unnamed protein productHomo sapiens
1284AAH019361357100BC001936 Similar to BCL2-Homo sapiens
associated athanogene
1284AAH147741357100BC014774 Unknown (protein forHomo sapiens
MGC: 17086)
1284Z354911357100glucocortoid receptor-associatedHomo sapiens
protein RAP46
1285AAH044901953100BC004490 v-fos FBJ murineHomo sapiens
osteosarcoma viral oncogene
homolog
1285AF1111671953100cfosHomo sapiens
1285V015121953100c-fosHomo sapiens
1286AAH20235328299BC020235 Unknown (protein forHomo sapiens
MGC: 31939)
1286M196453314100GRP78 precursorHomo sapiens
1286X879493314100BiPHomo sapiens
1287AAH144332640100BC014433 Unknown (protein forHomo sapiens
MGC: 2159)
1287BC0360002640100Unknown (protein forHomo sapiens
IMAGE: 4712175)
1287U420682640100P58Homo sapiens
1288BC0327221478100tumor necrosis factor (ligand)Homo sapiens
superfamily, member 10
1288U375181478100TNF-related apoptosis inducingHomo sapiens
ligand TRAIL
1288U570591478100Apo-2 ligandHomo sapiens
1289AAH010221591100BC001022 pyrophosphataseHomo sapiens
(inorganic)
1289AF119665_11591100AF119665 inorganicHomo sapiens
pyrophosphatase
1289AF217186_11591100AF217186 inorganicHomo sapiens
pyrophosphatase 1
1290AAH087433145100BC008743 zyxinHomo sapiens
1290AAH093603145100BC009360 zyxinHomo sapiens
1290AAH100313145100BC010031 zyxinHomo sapiens
1291AAH05901919100BC005901 Microfibril-associatedHomo sapiens
glycoprotein-2
1291AF084927919100microfibril-associatedHomo sapiens
glycoprotein 2
1291U37283919100microfibril-associatedHomo sapiens
glycoprotein-2 MAGP-2
1292AAH009332015100BC000933 isocitrate dehydrogenaseHomo sapiens
3 (NAD+) gamma
1292Z681292015100NAD (H)-specific isocitrateHomo sapiens
dehydrogenase gamma-subunit
precursor
1292Z689072015100NAD (H)-specific isocitrateHomo sapiens
dehydrogenase gamma subunit
precursor
1293AAH12265846100BC012265 Similar to cofilin 1,Homo sapiens
non-muscle
1293AAH12318846100BC012318 Similar to cofilin 1,Homo sapiens
non-muscle
1293AAH18256846100BC018256 Similar to cofilin 1,Homo sapiens
non-muscle
1294AB069964861100ubiquitin-conjugating enzyme 9Gallus
gallus
1294AF461016_1861100AF461016 ubiquitin-conjugatingGallus
enzymegallus
1294U88561861100E2 ubiquitin conjugating enzymeXenopus
laevis
1295AAH06249989100BC006249 guanylate kinase 1Homo sapiens
1295AAH09914989100BC009914 guanylate kinase 1Homo sapiens
1295U66895989100guanylate kinaseHomo sapiens
1296AF095770_122494AF095770 PTH-responsiveHomo sapiens
osteosarcoma D1 protein
1297AAH01120136999BC001120 lectin, galactoside-Homo sapiens
binding, soluble, 3 (galectin 3)
1297AF031425136999galectin 3Homo sapiens
1297M353681377100galactose-specific lectinHomo sapiens
1298AF241786_11125100AF241786 NPD013Homo sapiens
1299AAH0250354770BC002503 spermidine/spermine N1-Homo sapiens
acetyltransferase
1299AAH0842454770BC008424 spermdine/spermine N1-Homo sapiens
acetyltransferase
1299AF251292_11059100AF251292 DC21Homo sapiens
1300AF135157_119063AF135157 complement C1q A chainHomo sapiens
precursor
1300AF260332_11550100AF260332 DC33Homo sapiens
1300BC03015319063complement component 1, qHomo sapiens
subcomponent, alpha polypeptide
1301AAH00589770100BC000589 CGI-39 protein; cellHomo sapiens
death-regulatory protein GRIM19
1301AAH09189770100BC009189 CGI-39 protein; cellHomo sapiens
death-regulatory protein GRIM19
1301AF261134_11196100AF261134 CDA016Homo sapiens
1302AAH12296113599BC012296 hypothetical proteinHomo sapiens
FLJ21174
1302AF271783_11141100AF271783 NPD017Homo sapiens
1302AF314542_11141100AF314542 B lymphocyte activation-Homo sapiens
related protein
1303AK0904271394099FLJ00343 proteinHomo sapiens
1303L4414014011100filaminHomo sapiens
1303X534161400499actin-binding proteinHomo sapiens
1304AAH123411492100BC012341 Similar to M5-14 proteinHomo sapiens
1304AL1366221492100hypothetical proteinHomo sapiens
1304AL3900901492100c3orf1 hypothetical protein, M5-14Homo sapiens
similar to (AE003703) 140up
gene product Drosophila
melanogaster
1305AC005624824100MY18_HUMANHomo sapiens
1305AF078077824100growth arrest and DNA-damage-Homo sapiens
inducible protein GADD45beta
1305AF087853_1824100AF087853 growth arrest and DNAHomo sapiens
damage inducible protein beta
1306AF020185478100protein inhibitor of nitric oxideMus musculus
synthase
1306BC008106478100dynein, cytoplasmic, lightMus musculus
polypeptide
1306BC034258478100dynein, cytoplasmic, lightMus musculus
polypeptide
1307AAH015391466100BC001539 dickkopf (XenopusHomo sapiens
laevis) homolog 1
1307AF177394_11466100AF177394 dickkopf-1Homo sapiens
1307AF2611581466100dickkopf homolog 1Homo sapiens
1308AAC332791396100AC005559 basiginHomo sapiens
1308AAH090401396100BC009040 basigin (OK blood group)Homo sapiens
1308AF0428551396100EMMPRINHomo sapiens
1309L471253057100glypicanHomo sapiens
1309L471763057100GTR2-2 gene productHomo sapiens
1309Z379873057100MXR7Homo sapiens
1310D83476430677xtld proteinXenopus
laevis
1310L24755494892bone morphogenetic proteinMus musculus
1310U503305416100procollagen C-proteinaseHomo sapiens
1311AAH01287669100BC001287 histidine triadHomo sapiens
nucleotide-binding protein
1311AAH07090669100BC007090 histidine triadHomo sapiens
nucleotide-binding protein
1311U51004669100protein kinase C inhibitorHomo sapiens
1312AB003306128094PSMB5Mus musculus
1312AF060091_1128094AF060091 proteasome subunit XMus musculus
1312X955861370100proteasomeHomo sapiens
1313AF102848_12178100AF102848 keratin 23Homo sapiens
1313AK002047215198unnamed protein productHomo sapiens
1313BC028356215599type I intermediate filamentHomo sapiens
cytokeratin
1314AAH000973483100BC000097 transforming growthHomo sapiens
factor, beta-induced, 68 kD
1314AAR049723483100BC004972 transforming growthHomo sapiens
factor, beta-induced, 68 kD
1314AY1493443483100transforming growth factor, beta-Homo sapiens
induced, 68 kDa
1315AF414110_1635100AF414110 histone variant H2A.F/ZDanio rerio
1315AF414111_1635100AF414111 histone variant H2A.F/ZDanio rerio
1315V00414635100histone H2AGallus
gallus
1316BC011457957100Unknown (protein for MGC: 7976)Mus musculus
1316BC019761957100putative membrane proteinMus musculus
1316BC020098957100putative membrane proteinMus musculus
1317AAH001403579100BC000140 propionyl Coenzyme AHomo sapiens
carboxylase, alpha polypeptide
1317AF385926_13579100AF385926 propionyl-CoAHomo sapiens
carboxylase alpha subunit
1317AY0358083579100propionyl-CoA carboxylase alphaHomo sapiens
polypeptide precursor
1318AF372216_156299AF372216 tropomyosin alphaRattus
isoformnorvegicus
1318M19267565100tropomyosinHomo sapiens
1318M19715565100skeletal muscle tropomyosinHomo sapiens
1319AAH00191704100BC000191 hypothetical proteinHomo sapiens
1319AAH14329704100BC014329 Unknown (protein forHomo sapiens
MGC: 22862)
1319AF212248_1704100AF212248 CDA09Homo sapiens
1320AAH00255783100BC000255 Unknown (protein forHomo sapiens
MGC: 2495)
1320AF320778_1783100AF320778 cervical cancer oncogene 3Homo sapiens
1320AY032594783100hepatitis C virus core-bindingHomo sapiens
protein 6
1321AAH00271799100BC000271 Unknown (protein forHomo sapiens
MGC: 3204)
1321AAH01434799100BC001434 Unknown (protein forHomo sapiens
MGC: 2477)
1321AK00739044982unnamed protein productMus musculus
1322AAH004211243100BC000421 lysosomal-associatedHomo sapiens
protein transmembrane 4 alpha
1322AAH03158124099BC003158 lysosomal-associatedHomo sapiens
protein transmembrane 4 alpha
1322D146961243100KIAA0108Homo sapiens
1323AAH004611738100BC000461 eukaryotic translationHomo sapiens
initiation factor 2, subunit 2
(beta, 38 kD)
1323AAH00934173599BC000934 eukaryotic translationHomo sapiens
initiation factor 2, subunit 2
(beta, 38 kD)
1323AL0316681738100dJ64K7.2 (eukaryotic translationHomo sapiens
initiation factor 2, subunit 2
(beta, 38 kD))
1324AAH004661059100BC000466 NADH dehydrogenaseHomo sapiens
(ubiquinone) 1 beta subcomplex, 8
(19 kD, ASHI)
1324AAH192761059100BC019276 NADH dehydrogenaseHomo sapiens
(ubiquinone) 1 beta subcomplex, 8
(19 kD, ASHI)
1324AF0449581059100NADH: ubiquinone oxidoreductaseHomo sapiens
ASHI subunit
1325AAH004901821100BC000490 eukaryotic translationHomo sapiens
initiation factor 3, subunit 5
(epsilon, 47 KD)
1325AK095574177498unnamed protein productHomo sapiens
1325U948551821100translation initiation factor 3Homo sapiens
47 kDa subunit
1326AAH00502970100BC000502 ribosomal protein L17Homo sapiens
1326AAH17831970100BC017831 ribosomal protein L17Homo sapiens
1326X53777970100putative ribosomal protein (AA 1-184)Homo sapiens
1327AAH00505808100BC000505 microsomal glutathioneHomo sapiens
S-transferase 3
1327AAH03034808100BC003034 microsomal glutathioneHomo sapiens
S-transferase 3
1327AAH05964808100BC005964 microsomal glutathioneHomo sapiens
S-transferase 3
1328AAH005091425100BC000509 proteasome (prosome,Homo sapiens
macropain) subunit, beta type, 7
1328AAH171161393100BC017116 proteasome (prosome,Homo sapiens
macropain) subunit, beta type, 7
1328D38048142199proteasome subunit zHomo sapiens
1329BC0330154539100RAS p21 protein activator (GTPaseHomo sapiens
activating protein) 1
1329M233794539100GTPase-activating proteinHomo sapiens
1329M236124555100GTPase-activating proteinHomo sapiens
1330BC0038602254100protease (prosome, macropain) 26SMus musculus
subunit, ATPase 1
1330D506962254100proteasomal ATPase (S4)Rattus
norvegicus
1330U393022254100P26s4Mus musculus
1331AAH005222131100BC000522 Similar to serine (orHomo sapiens
cysteine) proteinase inhibitor,
clade F (alpha-2 antiplasmin,
pigment epithelium derived
factor). member 1
1331AF400442_1212599AF400442 pigment epithelium-Homo sapiens
derived factor
1331M76979211999pigment epithelial-Homo sapiens
differentiating factor
1332AAH005291616100BC000529 prostate differentiationHomo sapiens
factor
1332AAH089621616100BC008962 Unknown (protein forHomo sapiens
MGC: 4145)
1332AF003934161399prostate differentiation factorHomo sapiens
1333AAH00548806100BC000548 receptor (calcitonin)Homo sapiens
activity modifying protein 1
1333AF181550_159671AF181550 receptor activityRattus
modifying protein 1norvegicus
1333AJ001014806100RAMP1Homo sapiens
1334AAH005541409100BC000554 Similar to integralHomo sapiens
membrane protein 2B
1334AF136973_11409100AF136973 putative transmembraneHomo sapiens
protein E3-16
1334AF152462_11409100AF152462 transmembrane proteinHomo sapiens
BRI
1335AAH00601479100BC000601 DKFZP564K247 proteinHomo sapiens
1335AAH09583479100BC009583 DKFZP564K247 proteinHomo sapiens
1335AAH09594479100BC009594 DKFZP564K247 proteinHomo sapiens
1336AAH00691906100BC000691 brain specific proteinHomo sapiens
1336AF132972_190299AF132972 CGI-38 proteinHomo sapiens
1336BC01078888896RIKEN cDNA 2700055K07 geneMus musculus
1337AAH00720798100BC000720 ubiquitously-expressedHomo sapiens
transcript
1337AAH08890798100BC008890 ubiquitously-expressedHomo sapiens
transcript
1337AF092737_1798100AF092737 ubiquitously expressedHomo sapiens
transcript
1338AAH01016958100BC001016 NADH dehydrogenaseHomo sapiens
(ubiquinone) 1 alpha subcomplex,
8 (19 kD, PGIV)
1338AF044953_1958100AF044953 NADH: ubiquinoneHomo sapiens
oxidoreductase PGIV subunit
1338X596978668819 kDa subunit of NADH: ubiquinoneBos taurus
oxidoreductase complex (complex
I)
1339AAH01066763100BC001066 hypothetical proteinHomo sapiens
1339AAH21986763100BC021986 mitochondrial ribosomalHomo sapiens
protein L27
1339AB049647763100mitochondrial ribosomal proteinHomo sapiens
L27 (L27mt)
1340AAH011012975100BC001101 HSPC025Homo sapiens
1340AAH075102975100BC007510 HSPC025Homo sapiens
1340BC0292652975100eukaryotic translation initiationHomo sapiens
factor 3, subunit 6 interacting
protein
1341AAH011502803100BC001150 metalloprotease 1Homo sapiens
(pitrilysin family)
1341AAH05025280299BC005025 Similar toHomo sapiens
metalloprotease 1 (pitrilysin
family)
1341AB0290272803100KIAA1104 proteinHomo sapiens
1342AAH012882064100BC001288 Similar to decayHomo sapiens
accelerating factor for
complement (CD55, Cromer blood
group system)
1342M301422064100decay-accelerating factor AHomo sapiens
1342M315162064100decay-accelerating factorHomo sapiens
1343AAH01387833100BC001387 similar to rat HREV107Homo sapiens
1343AB030814833100H-REV107 protein homologHomo sapiens
1343AF317086833100HREV107-3Homo sapiens
1344AAH01420800100BC001420 HN1 proteinHomo sapiens
1344AF177862_1800100AF177862 HN1 proteinHomo sapiens
1344AF348672800100hematological and neurologicalHomo sapiens
expressed 1 protein
1345AAH01426482100BC001426 Similar to ubiquinol-Homo sapiens
cytochrome c reductase hinge
protein
1345AAH01934482100BC001934 Similar to ubiquinol-Homo sapiens
cytochrome c reductase hinge
protein
1345AAH15177482100BC015177 Unknown (protein forHomo sapiens
MGC: 10149)
1346AAH21173429100BC021173 normal mucosa ofHomo sapiens
esophagus specific 1
1346AB026707429100FOAP-11 proteinHomo sapiens
1346AF228422_1429100AF228422 normal mucosa ofHomo sapiens
esophagus specific 1
1347AF274958_1737100AF274958 PNAS-101Homo sapiens
1348AAH149081453100BC014908 stem-loop (histone)Homo sapiens
binding protein
1348AAH157031453100BC015703 stem-loop (histone)Homo sapiens
binding protein
1348Z711881453100histone RNA hairpin-bindingHomo sapiens
protein
1349AB0004912046100proteasome p45/SUGRattus
norvegicus
1349D835212046100proteasomal ATPase (rat SUG1)Rattus
norvegicus
1349Z542192046100mSUG1 proteinMus musculus
1350AK075215831100unnamed protein productHomo sapiens
1351AAH02481480100BC002481 HSPC162 proteinHomo sapiens
1351AF132750_1480100AF132750 bithoraxoid-like proteinHomo sapiens
1351AF178431_1480100AF178431 BITHHomo sapiens
1352AAH025593087100BC002559 high-glucose-regulatedHomo sapiens
protein 8
1352AK083882307799unnamed protein productMus musculus
1352BC014797307799Unknown (protein for MGC: 11691)Mus musculus
1353AAH025892230100BC002589 proteasome (prosome,Homo sapiens
macropain) 26S subunit, ATPase, 2
1353BC005462222699proteasome (prosome, macropain)Mus musculus
26S subunit, ATPase 2
1353D110942230100MSS1 proteinHomo sapiens
1354AAH026341769100BC002634 Unknown (protein forHomo sapiens
MGC: 4272)
1354AK003354173296unnamed protein productMus musculus
1354BC002128172596Unknown (protein for MGC: 6737)Mus musculus
1355AAH02803843100BC002803 hypothetical proteinHomo sapiens
1355AF151072_1843100AF151072 HSPC238Homo sapiens
1355BC00555971178RIKEN cDNA 2500002L14 geneMus musculus
1356AAH02911856100BC002911 Unknown (protein forHomo sapiens
MGC: 11276)
1356AK00323772284unnamed protein productMus musculus
1356BC03173272284DNA segment, Chr 7, Wayne StateMus musculus
University 86, expressed
1357AAH029452197100BC002945 Similar to hypotheticalHomo sapiens
protein FLJ10101
1357AAH210951290100BC021095 Unknown (protein forHomo sapiens
MGC: 31800)
1357AK0275861290100unnamed protein productHomo sapiens
1358AAH029542552100BC002954 UDP-glucoseHomo sapiens
pyrophosphorylase 2
1358BC023810252498UDP-glucose pyrophosphorylase 2Mus musculus
1358U27460254299uridine diphosphoglucoseHomo sapiens
pyrophosphorylase
1359AAH03005886100BC003005 unactive progesteroneHomo sapiens
receptor, 23 kD
1359BC00370887698telomerase binding protein, p23Mus musculus
1359L24804886100p23Homo sapiens
1360AAH030562132100BC003056 HSPC028 proteinHomo sapiens
1360AAH084532132100BC008453 HSPC028 proteinHomo sapiens
1360AAH095972132100BC009597 HSPC028 proteinHomo sapiens
1361L2907515124G-box binding factorDictyostelium
discoideum
1362AAH01773591100BC001773 Similar to ribosomalHomo sapiens
protein L34
1362AB061832591100ribosomal protein L34Homo sapiens
1362BC02851758799Unknown (protein for MGC: 41239)Mus musculus
1363AAH01882533100BC001882 Similar to ribosomalHomo sapiens
protein L5
1363D10737512100ribosomal protein L5Gallus
gallus
1363X57016512100ribosomal protein L5Gallus
gallus
1364AAH01884589100BC001884 NADH dehydrogenaseHomo sapiens
(ubiquinone) Fe-S protein 5
(15 kD) (NADH-coenzyme Q
reductase)
1364AF020352589100NADH: ubiquinone oxidoreductase 15 kDaHomo sapiens
IP subunit
1364AF047434589100NADH-ubiquinone oxidoreductaseHomo sapiens
15 kDa subunit; CI-15 protein
1365AAH019262197100BC001926 creatine kinase,Homo sapiens
mitochondrial 1 (ubiquitous)
1365AAH064672197100BC006467 creatine kinase,Homo sapiens
mitochondrial 1 (ubiquitous)
1365J044692197100creatine kinaseHomo sapiens
1366AAH03373763100BC003373 prefoldin 5Homo sapiens
1366AB055803763100MM-1 alphaHomo sapiens
1366D89667763100c-myc binding proteinHomo sapiens
1367AAH05939998100BC005939 prostaglandin D2Homo sapiens
synthase (21 kD, brain)
1367AY026356998100prostaglandin D synthaseHomo sapiens
1367M98539998100prostaglandin D2 synthaseHomo sapiens
1368AAH000451388100BC000045 TONDUHomo sapiens
1368AAH033621388100BC003362 TONDUHomo sapiens
1368Z976321388100dJ196E23.1.1 (novel protein)Homo sapiens
(isoform 1)
1369AAH03366796100BC003366 calcium-regulated heat-Homo sapiens
stable protein (24 kD)
1369AF115345_178799AF115345 calcium-regulated heatHomo sapiens
stable protein CRHSP-24
1369AF115346_178597AF115346 calcium-regulated heatRattus sp.
stable protein CRHSP-24
1370AAH03369581100BC003369 ribosomal protein,Homo sapiens
large, P1
1370AAH07590581100BC007590 ribosomal protein,Homo sapiens
large, P1
1370AB061836581100ribosomal protein P1Homo sapiens
1371AAH03377550100BC003377 Similar to thioredoxinHomo sapiens
1371AF313911_1550100AF313911 thioredoxinHomo sapiens
1371AY004872550100thioredoxinHomo sapiens
1372BC0324931086100cysteine and glycine-rich protein 1Homo sapiens
1372M331461086100cysteine-rich proteinHomo sapiens
1372M763781086100cysteine-rich proteinHomo sapiens
1373AAH033822620100BC003382 sorting nexin 2Homo sapiens
1373AF065482261299sorting nexin 2Homo sapiens
1373AK075929256498unnamed protein productMus musculus
1374AAH033941485100BC003394 heterogeneous nuclearHomo sapiens
ribonucleoprotein C (C1/C2)
1374AAH08364147899BC008364 heterogeneous nuclearHomo sapiens
ribonucleoprotein C (C1/C2)
1374AAH08423146195BC008423 heterogeneous nuclearHomo sapiens
ribonucleoprotein C (C1/C2)
1375AAH035012155100BC003501 Similar to RIKEN cDNAHomo sapiens
2310001A20 gene
1375AB0337672155100brain-selective and closelyHomo sapiens
mapped on the counter allele of
CMAP in cystatin cluster
1375AL0356612155100dJ568C11.2 (chromosome 20 openHomo sapiens
reading frame 3)
1376AAH035123204100BC003512 mesothelinHomo sapiens
1376AE006464_21318999AE006464 pre-pro-megakarycyteHomo sapiens
potentiating factor precursor
1376D49441319299pre-pro-megakaryocyteHomo sapiens
potentiating factor
1377AAH030775288100BC003077 Similar to ATPase, Na+K+Homo sapiens
transporting, alpha 1 polypeptide
1377D000995288100Na, K-ATPase alpha-subunitHomo sapiens
1377X042975288100ATPase alpha subunit (aa 1-1023)Homo sapiens
1378AAH03079786100BC003079 16.7 Kd proteinHomo sapiens
1378AAH15639786100BC015639 16.7 Kd proteinHomo sapiens
1378AF07884578610016.7 Kd proteinHomo sapiens
1379AAH001611827100BC000161 secretory carrierHomo sapiens
membrane protein 3
1379AAH051351827100BC005135 secretory carrierHomo sapiens
membrane protein 3
1379AF005039181799secretory carrier membraneHomo sapiens
protein
1380AAH08704887100BC008704 cytochrome c oxidaseHomo sapiens
subunit IV
1380AAH21236887100BC021236 cytochrome c oxidaseHomo sapiens
subunit IV isoform 1
1380X54802887100cytochrome-c oxidase subunit IVHomo sapiens
1381AAH009151731100BC000915 PDZ and LIM domain 1Homo sapiens
(elfin)
1381AAH187551731100BC018755 PDZ and LIM domain 1Homo sapiens
(elfin)
1381AJ3105491731100CLP-36 proteinHomo sapiens
1382AF236636130298uridine-cytidine kinase 2Mus musculus
1382AF2366371333100uridine-cytidine kinase 2Homo sapiens
1382BC023789130298uridine-cytidine kinase 2Mus musculus
1383AAH00176940100BC000176 RAP1B, member of RASHomo sapiens
oncogene family
1383AF493913_1940100AF493913 Ras family small GTPHomo sapiens
binding protein RAP1B
1383BC033382101691RAP1B, member of RAS oncogeneMus musculus
family
1384D63519870100leptinHomo sapiens
1384D63710870100ob proteinHomo sapiens
1384U43653870100obese proteinHomo sapiens
1385BC002088637100ribosomal protein S25Mus musculus
1385BC027208637100ribosomal protein S25Mus musculus
1385X62482637100ribosomal protein S25Rattus
Rattus
1386AAH036622092100BC003662 KIAA0111 gene productHomo sapiens
1386AAH043862092100BC004386 KIAA0111 gene productHomo sapiens
1386AAH111512092100BC011151 Similar to KIAA0111 geneHomo sapiens
product
1387AF349038_11780100AF349038 TFIID subunit TAFII55Homo sapiens
1387BC0327371780100similar to TAF7 RNA polymeraseHomo sapiens
II, TATA box binding protein
(TBP)-associated factor, 55 kD
1387X979991780100transcription factor IIDHomo sapiens
1388AAH026011673100BC002601 nuclear factor of kappaHom sapiens
light polypeptide gene enhancer
in B-cells inhibitor, alpha
1388AAH049831673100BC004983 nuclear factor of kappaHomo sapiens
light polypeptide gene enhancer
in B-cells inhibitor, alpha
1388AY0336001673100NFKBIAHomo sapiens
1389AF211480_12102100AF211480 CD001Homo sapiens
1389AK0021022086100unnamed protein productHomo sapiens
1389AX1915052086100unnamed protein productHomo sapiens
1390AAH051104609100BC005110 Unknown (protein forHomo sapiens
MGC: 13217)
1390AK049371447393unnamed protein productMus musculus
1390AY0448654609100sorting nexin 14Homo sapiens
1391AAH05118592100BC005118 Similar to putativeHomo sapiens
translation initiation factor
1391AAH08710592100BC008710 putative translationHomo sapiens
initiation factor
1391AF083441_1592100AF083441 SUI1 isologHomo sapiens
1392AAH051272190100BC005127 adipose differentiation-Homo sapiens
related protein
1392AF443203_12190100AF443203 adipose differentiation-Homo sapiens
related protein
1392AX025098218199unnamed protein productHomo sapiens
1393AAH05143964100BC005143 vitamin A responsive;Homo sapiens
cytoskeleton related
1393AAH20797964100BC020797 vitamin A responsive;Homo sapiens
cytoskeleton related
1393AY102608964100JWA proteinHomo sapiens
1394AAH05228360100BC005228 Unknown (protein forHomo sapiens
MGC: 12250)
1395AF0725062871100envelope protein precursorHomo sapiens
1395AF208161286899syncytin precursorHomo sapiens
1395AF513360_1286899AF513360 enverinHomo sapiens
1396AAH053221866100BC005322 decorinHomo sapiens
1396AF1383001866100decorin variant AHomo sapiens
1396AF491944_11866100AF491944 decorinHomo sapiens
1397AAH01392827100BC001392 ribosomal protein S27aHomo sapiens
1397D83209827100ubiquitin extention proteinCavia
porcellus
1397M24507827100ubiquitinsynthetic
construct
1398AAH053301306100BC005330 tissue factor pathwayHomo sapiens
inhibitor 2
1398AF2175421306100tissue factor pathway inhibitor 2Homo sapiens
1398D299921306100placental protein 5 (PP5)Homo sapiens
1399AAH053611334100BC005361 proteasome (prosome,Homo sapiens
macropain) subunit, alpha type, 4
1399BC0224451334100proteasome (prosome, macropain)Homo sapiens
subunit, alpha type, 4
1399D007631334100proteasome subunit C9Homo sapiens
1400AAH053661298100BC005366 ATP synthase, H+Homo sapiens
transporting, mitochondrial F0
complex, subunit b, isoform 1
1400AAH163501298100BC016350 Unknown (protein forHomo sapiens
MGC: 24431)
1400AL3901951298100bA552M11.3 (ATP synthase, H+Homo sapiens
transporting, mitochondrial F0
complex, subunit b, isoform 1)
1401AAH053901993100BC005390 Unknown (protein forHomo sapiens
MGC: 12520)
1401AF006305199310026S proteasome regulatory subunitHomo sapiens
1401U363951993100conserved ATPase domain proteinSpermophilus
44tridecemlineatus
1402AAH10370180099BC010370 Putative prostate cancerHomo sapiens
tumor suppressor
1402U42349182610039 kDa encoded by N33Homo sapiens
1402U42360180899N33 protein form 1Homo sapiens
1403AAH058391492100BC005839 follistatin-like 3Homo sapiens
(secreted glycoprotein)
1403BC0331191492100follistatin-like 3 (secretedHomo sapiens
glycoprotein)
1403U767021492100follistatin-related protein FLRGHomo sapiens
1404AAH05354564100BC005354 ribosomal protein, largeHomo sapiens
P2
1404AAH05920564100BC005920 ribosomal protein, largeHomo sapiens
P2
1404AAH07573564100BC007573 ribosomal protein, largeHomo sapiens
P2
1405AAH17660414100BC017660 Unknown (protein forHomo sapiens
MGC: 14608)
1405AJ249731414100putative G8.2 proteinHomo sapiens
1405AP000503414100unknown functionHomo sapiens
1406AAH05966647100BC005966 ring finger protein 7Homo sapiens
1406AAH08627647100BC008627 ring finger protein 7Homo sapiens
1406AF092878_1647100AF092878 zinc RING finger proteinHomo sapiens
SAG
1407AAH059751163100BC005975 calcyclin bindingHomo sapiens
protein
1407AF314752_11163100AF314752 calcyclin bindingHomo sapiens
protein
1407BC0223521163100Siah-interacting proteinHomo sapiens
1408AAH06337739100BC006337 Unknown (protein forHomo sapiens
MGC: 12798)
1408M37194739100clathrin-associated protein 17Rattus
norvegicus
1408X9707472998clathrin-associated proteinHomo sapiens
1409AAH019283365100BC001928 protein disulfideHomo sapiens
isomerase related protein
(calcium-binding protein,
intestinal-related)
1409AAH063443365100BC006344 protein disulfideHomo sapiens
isomerase related protein
(calcium-binding protein,
intestinal-related)
1409AAH117543365100BC011754 Similar to proteinHomo sapiens
disulfide isomerase related
protein (calcium-binding protein,
intestinal-related)
1410AF453478_11155100AF453478 phosphopantetheineHomo sapiens
adenylyltransferase/
dephosphocoenzyme A kinase
1410AY0946021155100bifunctional phosphopantetheineHomo sapiens
adenylyl transferase/dephospho
CoA kinase
1410BC0209851155100Unknown (protein for MGC: 9724)Homo sapiens
1411AAH063932797100BC006393 Similar toHomo sapiens
carboxypeptidase Z
1411AF017638241986carboxypeptidase ZRattus
norvegicus
1411U83411278799carboxypeptidase Z precursorHomo sapiens
1412AF126110_13913100AF126110 fibulin-1 isoform DHomo sapiens
precursor
1412U012443913100fibulin-1DHomo sapiens
1412X70854339284BH-90/fibulinMus musculus
1413AAH023432494100BC002343 Similar to nucleolinHomo sapiens
1413AAH064942494100BC006494 Unknown (protein forHomo sapiens
MGC: 1440)
1413AAH065162494100BC006516 Unknown (protein forHomo sapiens
MGC: 3588)
1414AAH20515772100BC020515 ribosomal protein S14Homo sapiens
1414M11241772100ribosomal protein S14Cricetulus
griseus
1414M35008772100ribosomal protein S14Cricetulus
griseus
1415AAH0892679698BC008926 ribosomal protein L29Homo sapiens
1415U1024879698ribosomal protein L29Homo sapiens
1415U4908379698HIPHomo sapiens
1416AAH067911105100BC006791 ribosomal protein L10aHomo sapiens
1416AAH113661105100BC011366 Similar to ribosomalHomo sapiens
protein L10a
1416X933521105100ribosomal protein L10aRattus
norvegicus
1417AAH014181132100BC001418 Similar to RIKEN cDNAHomo sapiens
1810017F10 gene
1417AAH139531132100BC013953 Unknown (protein forHomo sapiens
MGC: 2853)
1417AY0275431132100beta-casein-like proteinHomo sapiens
1418AAH070381762100BC007038 lumicanHomo sapiens
1418BC0359971762100lumicanHomo sapiens
1418U211281762100lumicanHomo sapiens
1419AAH036091441100BC003609 thioredoxin peroxidaseHomo sapiens
(antioxidant enzyme)
1419AAH071071441100BC007107 thioredoxin peroxidaseHomo sapiens
(antioxidant enzyme)
1419AAH167701441100BC016770 thioredoxin peroxidaseHomo sapiens
(antioxidant enzyme)
1420AAH07282952100BC007282 Unknown (protein forHomo sapiens
MGC: 15626)
1420AK01433890997unnamed protein productMus musculus
1420M8375193798arginine-rich proteinHomo sapiens
1421AAH074021005100BC007402 apolipoprotein DHomo sapiens
1421J026111005100apolipoprotein D precursorHomo sapiens
1421M166961005100apolipoprotein D precursorHomo sapiens
1422AAH01603849100BC001603 Similar to ribosomalHomo sapiens
protein L21
1422AAH07505849100BC007505 Unknown (protein forHomo sapiens
MGC: 4136)
1422X89401849100ribosomal protein L21Homo sapiens
1423AAH07507605100BC007507 ribosomal protein S20Homo sapiens
1423BC011323605100Similar to ribosomal protein S20Mus musculus
1423X51537605100ribosomal protein S20 (AA 1-119)Rattus
Rattus
1424AAH14459791100BC014459 Similar to ribosomalHomo sapiens
protein L23a
1424BC029892791100ribosomal protein L23aMus musculus
1424X65228791100ribosomal protein L23aRattus
Rattus
1425AJ420896211499SPPL2a proteinHomo sapiens
1425AK0274462126100unnamed protein productHomo sapiens
1425BC025740211499Similar to hypothetical proteinHomo sapiens
FLJ14540
1426AF03654857383RGC-32Rattus
norvegicus
1426AF036549_1569100AF036549 RGC32Homo sapiens
1426AL35483362992bA157L14.2 (RGC32, a novel geneHomo sapiens
induced by complement activation
in oligodendrocytes)
1427AAH01024274999BC001024 putative nucleotideHomo sapiens
binding protein, estradiol-
induced
1427AK0275142756100unnamed protein productHomo sapiens
1427AK027516275399unnamed protein productHomo sapiens
1428AAH07834563100BC007834 Unknown (protein forHomo sapiens
MGC: 14141)
1429AAH03061233899BC003061 protease, cysteine, 1Homo sapiens
(legumain)
1429D55696233599cysteine proteaseHomo sapiens
1429Y098622339100legumainHomo sapiens
1430AAH080811095100BC008081 Similar to KDEL (Lys-Homo sapiens
Asp-Glu-Leu) endoplasmic
reticulum protein retention
receptor 2
1430AAH145681095100BC014568 Similar to KDEL (Lys-Homo sapiens
Asp-Glu-Leu) endoplasmic
reticulum protein retention
receptor 2
1430X637451095100KDEL receptorHomo sapiens
1431AF004877757499pro-alpha 2(I) collagenHomo sapiens
1431J03464755499pre-pro-alpha-2 type I collagenHomo sapiens
1431Z746167596100prepro-alpha2(I) collagenHomo sapiens
1432AAH08188946100BC008188 Unknown (protein forHomo sapiens
MGC: 5243)
1432AF021819946100RNA-binding protein regulatoryHomo sapiens
subunit
1432AL034417946100bK215D11.1 (RNA-binding proteinHomo sapiens
regulatory subunit)
1433AAH08283594100BC008283 cholecystokininHomo sapiens
1433L00354594100cholecystokininHomo sapiens
1433M6045856995cholecystokininMacaca
fascicularis
1434AAH0679469399BC006794 Similar to interferonHomo sapiens
induced transmembrane protein 3
(1-8U)
1434AAH08417698100BC008417 Similar to interferonHomo sapiens
induced transmembrane protein 3
(1-8U)
1434BC022439698100interferon induced transmembraneHomo sapiens
protein 3 (1-8U)
1435AAH059931421100BC005993 Unknown (protein forHomo sapiens
MGC: 14796)
1435AAH086911421100BC008691 Unknown (protein forHomo sapiens
MGC: 8886)
1435AAH156441421100BC015644 Ras suppressor protein 1Homo sapiens
1436AAH089381942100BC008938 Similar toHomo sapiens
histocompatibility 13
1436AAH089591942100BC008959 Similar toHomo sapiens
histocompatibility 13
1436AF483215_1193499AF483215 minor histocompatibilityHomo sapiens
antigen H13 isoform 1
1437AAH163202150100BC016320 cathepsin D (lysosomalHomo sapiens
aspartyl protease)
1437M112332150100preprocathepsin DHomo sapiens
1437X053442150100precursor polypeptide (AA −20 toHomo sapiens
392)
1438AAH089831364100BC008983 complement component 1,Homo sapiens
q subcomponent, beta polypeptide
1438X030841240100C1q B-chain precursorHomo sapiens
1438X16874107579precursor polypeptide (AA −25 toMus musculus
228)
1439AAH091771014100BC009177 ras homolog gene family,Homo sapiens
member C
1439AF498972_11014100AF498972 small GTP bindingHomo sapiens
protein RhoC
1439BC0046271014100ras homolog gene family, member CMus musculus
1440AAH092001068100BC009200 Rho GDP dissociationHomo sapiens
inhibitor (GDI) beta
1440AF498927_11068100AF498927 Rho GDP dissociationHomo sapiens
inhibitor beta
1440X695491068100Human rho GDP-dissociationHomo sapiens
Inhibitor 2(IEF 8120)
1441AAH092011137100BC009201 clathrin, lightHomo sapiens
polypeptide (Lca)
1441AAH192871137100BC019287 clathrin, lightHomo sapiens
polypeptide (Lca)
1441AL1588301137100bA421H8.4.2 (clathrin, lightHomo sapiens
polypeptide (LCA))
1442AAH09232596100BC009232 Similar to G antigen 8Homo sapiens
1442AJ318880596100XAGE-2 proteinHomo sapiens
1442AJ318891596100XAGE-2 proteinHomo sapiens
1443AAH033781149100BC003378 high-mobility groupHomo sapiens
(nonhistone chromosomal) protein 1
1443BC0309811149100high-mobility group (nonhistoneHomo sapiens
chromosomal) protein 1
1443X125971149100HMG-1 protein (AA 1-215)Homo sapiens
1444AB0023685586100KIAA0370Homo sapiens
1444AY0263885765100ran binding protein RanBP20Homo sapiens
1444AY029528566397RANBP20Mus musculus
1445AAH097991308100BC009799 amphiregulinHomo sapiens
(schwannoma-derived growth
factor)
1445M307031308100amphiregulinHomo sapiens
1445M307041308100amphiregulinHomo sapiens
1446AAH09869511100BC009869 Unknown (protein forHomo sapiens
MGC: 16406)
1446AAH15491511100BC015491 Unknown (protein forHomo sapiens
MGC: 8965)
1446BC022326511100Unknown (protein for MGC: 22741)Homo sapiens
1447AAH098981921100BC009898 spermine synthaseHomo sapiens
1447AD0015281921100spermidine aminopropyltransferaseHomo sapiens
1447Z490991916100spermine synthaseHomo sapiens
1448AL3654101055100hypothetical proteinHomo sapiens
1449AAH100161542100BC010016 Similar to CD47 antigenHomo sapiens
(Rh-related antigen, integrin-
associated signal transducer)
1449AAH128841542100BC012884 Unknown (protein forHomo sapiens
MGC: 9240)
1449Z255211542100integrin associated proteinHomo sapiens
1450AAH10055784100BC010055 hypothetical proteinHomo sapiens
PRO2605
1450AF116721_109642100AF116709 PRO2605Homo sapiens
1451AAH04976634100BC004976 Unknown (protein forHomo sapiens
IMAGE: 2958115)
1451AAH10076634100BC010076 Unknown (protein forHomo sapiens
MGC: 19576)
1451AY061855634100mitochondrial ribosomal proteinHomo sapiens
S6
1452AAH10129907100BC010129 Similar to hypotheticalHomo sapiens
protein R33729_1
1452AAH14655907100BC014655 Unknown (protein forHomo sapiens
MGC: 20383)
1452AL365374894100R33729_1 hypothetical proteinHomo sapiens
1453AB028894824100ribosomal protein S11Mus musculus
1453BC012641824100ribosomal protein S11Mus musculus
1453U93864824100ribosomal protein S11Mus musculus
1454BC0020771058100RAB1, member RAS oncogene familyMus musculus
1454X157441058100GTP-binding proteinMus musculus
1454Y000941058100Ypt1 protein (AA 1-205)Mus musculus
1455AAH029471482100BC002947 folate receptor 1Homo sapiens
(adult)
1455U203911482100folate receptorHomo sapiens
1455X627531482100adult folate binding proteinHomo sapiens
1456U659323016100extracellular matrix protein 1Homo sapiens
1456U659383016100extracellular matrix protein 1Homo sapiens
1456U681863016100extracellular matrix protein 1Homo sapiens
1457AAH10897541100BC010897 Similar to JM27 proteinHomo sapiens
1457AF275258_1541100AF275258 PAGE-4Homo sapiens
1457AJ005894541100JM27Homo sapiens
1458AAH111712528100BC011171 serine (or cysteine)Homo sapiens
proteinase inhibitor, clade G (C1
inhibitor), member 1
1458AF435921_1252499AF435921 C1 esterase inhibitorHomo sapiens
1458X07427252499C1 inhibitorHomo sapiens
1459D38112180393cytochrome bHomo sapiens
1459U09500180293cytochrome bHomo sapiens
1459V00662180793cytochrome BHomo sapiens
1460AAH11514696100BC011514 Similar to ribosomalHomo sapiens
protein L32
1460K02060696100ribosomal protein L32-3AMus musculus
1460X06483696100ribosomal protein L32Rattus
norvegicus
1461AAH11786645100BC011786 Unknown (protein forHomo sapiens
MGC: 19839)
1461AF318382_1645100AF318382 unknownHomo sapiens
1461X078684561001.8 kb mRNA (AA 1-84)Homo sapiens
1462AAH117921649100BC011792 Unknown (protein forHomo sapiens
MGC: 19561)
1462AAH17408164399BC017408 Unknown (protein forHomo sapiens
MGC: 27221)
1462U16660160397peroxisomal enoyl-CoA hydratase-Homo sapiens
like protein
1463AAH001592163100BC000159 keratin 17Homo sapiens
1463AAH119012163100BC01901 Similar to keratin 17Homo sapiens
1463X625712163100keratin related productHomo sapiens
1464AAH121323933100BC012132 Similar to DEAD/H (Asp-Homo sapiens
Glu-Ala-Asp/His) box polypeptide 1
1464BC010624387297Unknown (protein for MGC: 11570)Mus musculus
1464X706493933100member of DEAD box protein familyHomo sapiens
1465AF157623_12466100AF157623 HTRA serine proteaseHomo sapiens
1465D872582466100serin protease with IGF-bindingHomo sapiens
motif
1465Y079212466100novel serine protease, PRSS11Homo sapiens
1466AF242550_11030100AF242550 cellular nucleic acidRattus
binding proteinnorvegicus
1466AF3898871030100zinc finger protein 9Homo sapiens
1466D452541030100Cellular Nucleic Acid BindingRattus
Proteinnorvegicus
1467AAH142771191100BC014277 Similar to tissueHomo sapiens
inhibitor of metalloproteinase 3
(Sorsby fundus dystrophy,
pseudoinflammatory)
1467U331141191100tissue inhibitor ofHomo sapiens
metalloproteinases-3
1467X762271191100tissue inhibitor ofHomo sapiens
metalloproteinases-3
1468AAH123841017100BC012384 Similar to programmedHomo sapiens
cell death 6
1468AF0356061017100calcium binding proteinHomo sapiens
1468U58773_11017100U58773 calcium binding proteinHomo sapiens
1469AAH12464755100BC012464 prefoldin 2Homo sapiens
1469AF117237_1755100AF117237 prefoldin subunit 2Homo sapiens
1469BC02683972996Similar to prefoldin 2Mus musculus
1470AAH08230849100BC008230 ribosomal protein L12Homo sapiens
1470BC01832184899ribosomal protein L12Mus musculus
1470L06505849100ribosomal protein L12Homo sapiens
1471AAH126061665100BC012606 Similar to proteasomeHomo sapiens
(prosome, macropain) 26S subunit,
non-ATPase, 7 (Mov34 homolog)
1471D50063163798proteasome subunit p40/Mov34Homo sapiens
protein
1471M6464015979636 kD proteinMus musculus
1472AAH118351485100BC011835 Similar to ATPase,Homo sapiens
Na+/K+ transporting, beta 3
polypeptide
1472AF0058961485100Na K-ATPase beta-3 subunitHomo sapiens
1472U514781485100sodium/potassium-transportingHomo sapiens
ATPase beta-3 subunit
1473AAH130415526100BC013041 Unknown (protein forHomo sapiens
MGC: 4781)
1473M580285526100ubiquitin-activating enzyme E1Homo sapiens
1473X56976551699ubiquitin activating enzyme E1Homo sapiens
1474AAH13162491100BC013162 Similar to heat shockHomo sapiens
protein, 30 kDa
1474AF085359491100HSPC030Homo sapiens
1474AF537132491100selenoprotein KHomo sapiens
1475AAH13175992100BC013175 Similar to novel RGD-Homo sapiens
containing protein
1475BC02924995896dynactin 6Mus musculus
1475D84145992100WS-3Homo sapiens
1476BC0038252344100tubulin, beta 5Mus musculus
1476X046632344100beta-tubulin AA 1-444 (79 is 1stMus musculus
base in codon)
1476X070112344100c(beta)7 tubulin (AA 1-444)Gallus
gallus
1477A47413333696CALPASTATINE HUMAINEHomo sapiens
1477AAH135793420100BC013579 Similar to calpastatinHomo sapiens
1477D16217334093calpastatinHomo sapiens
1478BC024378567100defender against cell death 1Mus musculus
1478Y13335567100DAD-1Mus musculus
1478Y13336567100DAD-1Rattus
norvegicus
1479AAH139753963100BC013975 Similar to sema domain,Homo sapiens
immunoglobulin domain (Ig), short
basic domain, secreted,
(semaphorin) 3B
1479BC0242203963100Unknown (protein for MGC: 1483)Homo sapiens
1479U28369395199semaphorin VHomo sapiens
1480AAH141423503100BC014142 Similar toHomo sapiens
glucuronidase, beta
1480AX147652349699unnamed protein productHomo sapiens
1480M15182349699beta-glucuronidase precursor (ECHomo sapiens
3.2.1.31)
1481AB022163202492mouse ortholog of the zebrafishMus musculus
hagoromo gene
1481AF2818592217100dactylinHomo sapiens
1481BC027031202492f-box and WD-40 domain protein 4Mus musculus
1482AAH013771114100BC001377 DKFZP586G1722 proteinHomo sapiens
1482AAH065141114100BC006514 DKFZP586G1722 proteinHomo sapiens
1482AAH143911114100BC014391 DKFZP586G1722 proteinHomo sapiens
1483AF159256_11147100AF159256 Lps/Ran GTPaseMus musculus
1483AF306457_11147100AF306457 GTPaseRattus
norvegicus
1483BC0148291147100RAN, member RAS oncogene familyMus musculus
1484AAH150001347100BC015000 Similar to majorHomo sapiens
histocompatibility complex, class
II, DP beta 1
1484M57466130696light chainHomo sapiens
1484X01426130196SB-2-beta precursor polypeptideHomo sapiens
(aa −29 to 229)
1485AAH150391006100BC015039 microfibrillar-Homo sapiens
associated protein 2
1485AL0495691006100dJ37C10.4 (microfibrillar-Homo sapiens
associated protein 2
(microfibril-associated
glycoprotein precursor, MGAP1))
1485U197181006100microfibril-associatedHomo sapiens
glycoprotein
1486AF117383_1746100AF117383 placental protein 13;Homo sapiens
PP13
1486AY055826746100placenta protein 13Homo sapiens
1486BC02225751069Similar to placental protein 13-Homo sapiens
like protein
1487AAH023872063100BC002387 nucleosome assemblyHomo sapiens
protein 1-like 1
1487AAH155992063100BC015599 nucleosome assemblyHomo sapiens
protein 1-like 1
1487AL1620682063100hypothetical proteinHomo sapiens
1488A03911201799glia-derived neurite-promotingHomo sapiens
factor (GdNPF)
1488AAH156632040100BC015663 Similar to serine (orHomo sapiens
cysteine) proteinase inhibitor,
clade E (nexin, plasminogen
activator inhibitor type 1)
member 2
1488M17783201699glia-derived nexin precursorHomo sapiens
1489AAH024033107100BC002403 lectin, galactoside-Homo sapiens
binding, soluble, 3 binding
protein (galectin 6 binding
protein)
1489AAH029983107100BC002998 lectin, galactoside-Homo sapiens
binding, soluble, 3 binding
protein (galectin 6 binding
protein)
1489AAH157613107100BC015761 lectin, galactoside-Homo sapiens
binding, soluble, 3 binding
protein
1490AAH150322122100BC015032 ribosomal protein L3Homo sapiens
1490AAH157672122100BC015767 ribosomal protein L3Homo sapiens
1490BC0080032122100ribosomal protein L3Homo sapiens
1491AF0526942391100alpha-tubulinMeriones
unguiculatus
1491BC0022192391100Similar to tubulin alpha 1Mus musculus
1491BC0081172391100tubulin alpha 1Mus musculus
1492AAH2182226471BC021822 Unknown (protein forHomo sapiens
MGC: 24986)
1492AK02511626571unnamed protein productHomo sapiens
1492AK09051127971unnamed protein productHomo sapiens
1493AAH02449119699BC002449 Similar to CG10641 geneHomo sapiens
product
1493AAH04128133199BC004128 Unknown (protein forHomo sapiens
IMAGE: 3940060)
1493AK0236741199100unnamed protein productHomo sapiens
1494AAH015372971100BC001537 Unknown (protein forHomo sapiens
MGC: 786)
1494AB021743296899PR65Mus musculus
14942C006606296899protein phosphatase 2 (formerlyMus musculus
2A), regulatory subunit A (PR
65), alpha isoform
1495AAH09642939100BC009642 FXYD domain-containingHomo sapiens
ion transport regulator 5
1495AB072911939100dysadherinHomo sapiens
1495AF161462_192398AF161462 HSPC113Homo sapiens
1496AAH09687869100BC009687 epithelial membraneHomo sapiens
protein 2
1496AY057060869100epithelial membrane protein 2Homo sapiens
1496U52100869100XMPHomo sapiens
1497AB012214672778DNA cytosine 5 methyltransferaseRattus
Rattus
1497AF1806826869100DNA (cytosine-5)-Homo sapiens
methyltransferase
1497X636928587100DNA (cytosine-5-)-Homo sapiens
methyltransferase
1498AAH15961961100BC015961 adrenomedullinHomo sapiens
1498D14874961100adrenomedullin precursorHomo sapiens
1498S73906961100adrenomedullin; AMHomo sapiens
1499AAH15973514100BC015973 S100 calcium-bindingHomo sapiens
protein A10 (annexin II ligand,
calpactin I, light polypeptide
(p11))
1499M38591514100cellular ligand of annexin IIHomo sapiens
1499M81457514100calpactin I light chainHomo sapiens
1500AAH160561137100BC016056 claudin 3Homo sapiens
1500AB0007141137100RVP1Homo sapiens
1500AF0071891137100claudin 3Homo sapiens
1501AAH161421432100BC016142 Similar to RIKEN cDNAHomo sapiens
2310032N20 gene
1501AAH207731432100BC020773 Unknown (protein forHomo sapiens
MGC: 22685)
1501AX4058241432100unnamed protein productHomo sapiens
1502AF315378_1195598AF315378 suppressor ofRattus
profilin/p41 of actin-relatednorvegicus
complex 2/3
1502BC039594196499actin related protein 2/3Homo sapiens
complex, subunit 1A, 41 kDa
1502Y089991980100Sop2p-like proteinHomo sapiens
1503AF492677_1383100AF492677 odd homeobox 1 proteinHomo sapiens
isoform A
1503AF492680_1383100AF492680 odd homeobox 1 proteinHomo sapiens
isoform A
1503AF492681_1383100AF492681 odd homeobox 1 proteinHomo sapiens
isoform A
1504AK0569922163100unnamed protein productHomo sapiens
1504AX392121215599unnamed protein productHomo sapiens
1504AY033237215599alcohol dehydrogenase 8Homo sapiens
1505AAH16748485100BC016748 ribosomal protein L37aHomo sapiens
1505X14069485100ribosomal protein L37a (AA 1-92Rattus
Rattus
1505X73331485100ribosomal protein L37aMus musculus
1506AAH128073702100BC012807 Unknown (protein forHomo sapiens
MGC: 3483)
1506AAH144853702100BC014485 Unknown (protein forHomo sapiens
MGC: 23206)
1506AAH167533702100BC016753 Unknown (protein forHomo sapiens
MGC: 1138)
1507AAH158341724100BC015834 annexin A2Homo sapiens
1507AAH167741724100BC016774 annexin A2Homo sapiens
1507AAH211141724100BC021114 annexin A2Homo sapiens
1508AAH17343644100BC017343 ribosomal protein L31Homo sapiens
1508BC008223644100ribosomal protein L31Mus musculus
1508X04809644100ribosomal protein L31 (AA 1-125)Rattus
norvegicus
1509AAH173782955100BC017378 hexosaminidase B (betaHomo sapiens
polypeptide)
1509AF378118_12955100AF378118 cervical cancer proto-Homo sapiens
oncogene 7
1509M232942955100beta-hexosaminidase beta-subunitHomo sapiens
1510AAH121681373100BC012168 Similar to proteasomeHomo sapiens
(prosome, macropain) subunit,
beta type, 4
1510AAH174511373100BC017451 proteasome (prosome,Homo sapiens
macropain) subunit, beta type, 4
1510AAH174861373100BC017486 proteasome (prosome,Homo sapiens
macropain) subunit, beta type, 4
1511AAH061242618100BC006124 IMP (inosineHomo sapiens
monophosphate) dehydrogenase 2
1511AAH128402618100BC012840 IMP (inosineHomo sapiens
monophosphate) dehydrogenase 2
1511AAH155672618100BC015567 IMP (inosineHomo sapiens
monophosphate) dehydrogenase 2
1512AAH074571103100BC007457 hypothetical proteinHomo sapiens
1512AAH207961103100BC020796 hypothetical proteinHomo sapiens
HSPC177
1512AAH211681103100BC021168 hypothetical proteinHomo sapiens
HSPC177
1513AAH04904289499BC004904 nuclear RNA exportHomo sapiens
factor 1
1513BC028041289499nuclear RNA export factor 1Homo sapiens
1513U800732905100tip associating proteinHomo sapiens
1514AF064238_1450397AF064238 smoothelin large isoformHomo sapiens
L2
1514AY0619714653100smoothelin-B2Homo sapiens
1514AY061972453396smoothelin-B3Homo sapiens
1515AAH177731214100BC017773 triggering receptorHomo sapiens
expressed on myeloid cells 1
1515AF196329_11214100AF196329 triggering receptorHomo sapiens
expressed on monocytes 1
1515AF287008_11214100AF287008 triggering receptorHomo sapiens
expressed on monocytes 1
1516AAH17891579100BC017891 vesicle-associatedHomo sapiens
membrane protein 5 (myobrevin)
1516AF054825579100VAMP5Homo sapiens
1516AF077197579100VAMP5-like proteinHomo sapiens
1517AAH17931819100BC017931 Similar to RIKEN cDNAHomo sapiens
1110055A02 gene
1517AF400652_1819100AF400652 thyroid hormone receptorHomo sapiens
interacting protein 3
1517L40410806100thyroid receptor interactorHomo sapiens
1518AAH187321606100BC018732 Unknown (protein forHomo sapiens
MGC: 31847)
1518AF125533_11606100AF125533 NADH-cytochrome b5Homo sapiens
reductase isoform
1518AX0834211606100unnamed protein productHomo sapiens
1519AAH024533263100BC002453 heat shock 70 kD proteinHomo sapiens
1A
1519AAH093223263100BC009322 heat shock 70 kD proteinHomo sapiens
1A
1519AAH187403263100BC018740 heat shock 70 kD proteinHomo sapiens
1A
15201680052_12856100S62076 lysosomal enzyme beta-N-Homo sapiens
acetylhexosaminidase A
1520AAH189272856100BC018927 hexosaminidase A (alphaHomo sapiens
polypeptide)
1520M164242856100beta-hexosaminidase alpha chainHomo sapiens
1521AAH12992211599BC012992 Similar to RNA bindingHomo sapiens
motif, single stranded
interacting protein 1
1521AAH12993211599BC012993 Similar to RNA bindingHomo sapiens
motif, single stranded
interacting protein 1
1521AAH189512142100BC018951 RNA binding motif,Homo sapiens
single stranded interacting
protein 1
1522AAH16346908100BC016346 Unknown (protein forHomo sapiens
MGC: 24392)
1522AAH16354908100BC016354 Unknown (protein forHomo sapiens
MGC: 24480)
1522AAH18990908100BC018990 Unknown (protein forHomo sapiens
MGC: 20176)
1523AAH01206223599BC001206 Unknown (protein forHomo sapiens
MGC: 3208)
1523AK025822350599unnamed protein productHomo sapiens
1523AL8338653414100hypothetical proteinHomo sapiens
1524AAH06772769100BC006772 ribosomal protein S13Homo sapiens
1524BC029732769100ribosomal protein S13Homo sapiens
1524X53378769100ribosomal protein S13Rattus
Rattus
1525J051921982100alpha-actinHomo sapiens
1525X06801196899alpha-actin (AA 1-377)Rattus
Rattus
1525X13297196899alpha-actin (AA 1-377)Mus musculus
1526AAH00260167599BC000260 aldo-keto reductaseHomo sapiens
family 1, member B1 (aldose
reductase)
1526AAH10391167599BC010391 aldo-keto reductaseHomo sapiens
family 1, member B1 (aldose
reductase)
1526J050171677100aldose reductaseHomo sapiens
1527M222462623100aromatase precursor (ECHomo sapiens
1.14.14.1)
1527X135892623100aromatase (AA 1-503)Homo sapiens
1527Y07508262099aromatase (AA 1-503)Homo sapiens
1528M599163466100acid sphingomyelinaseHomo sapiens
1528M81780345099acid sphingomyelinaseHomo sapiens
1528X63600346199acid sphingomyelinaseHomo sapiens
1529AAH219931707100BC021993 guanine nucleotideHomo sapiens
binding protein (G protein), beta
polypeptide 2-like 1
1529M241931707100MHC B complex protein 12.3Gallus
gallus
1529X753131707100B complex protein mRNA 12-3Mus musculus
1530AAH05358642100BC005358 non-histone chromosomeHomo sapiens
protein 2 (S. cerevisiae)-like 1
1530AAH19282642100BC019282 non-histone chromosomeHomo sapiens
protein 2 (S. cerevisiae)-like 1
1530BC026755642100Similar to sperm specific antigen 1Mus musculus
1531AAH192962747100BC019296 chaperonin containingHomo sapiens
TCP1, subunit 7 (eta)
1531AF0262922747100chaperonin containing t-complexHomo sapiens
polypeptide 1, eta subunit; CCT-
eta
1531BC008255262895chaperonin subunit 7 (eta)Mus musculus
1532BC035220387999similar to complement componentHomo sapiens
1532M140583885100human complement C1rHomo sapiens
1532X04701387999precursor of C1r (AA −17 to 688)Homo sapiens
1533J040803789100complement component C1sHomo sapiens
1533M187673789100complement subcomponent C1sHomo sapiens
precursor
1533X065963789100complement protein C1s precursorHomo sapiens
1534AAH031752072100BC003175 N-myc downstreamHomo sapiens
regulated
1534AF0041622072100nickel-specific induction proteinHomo sapiens
1534D879532072100RTPHomo sapiens
1535AF085250759100calmodulinPerca
flavescens
1535D83350759100calmodulinAnas
platyrhynchos
1535K01945759100calmodulin (cDNA clone 71)Xenopus
laevis
1536AAH079112282100BC007911 calreticulinHomo sapiens
1536AAH204932282100BC020493 calreticulinHomo sapiens
1536AY0475862282100calreticulinHomo sapiens
1537AAH16300533100BC016300 S100 calcium-bindingHomo sapiens
protein A4 (calcium protein,
calvasculin, metastasin, murine
placental homolog)
1537Z18950533100CAPLHomo sapiens
1537Z33457533100mts1Homo sapiens
1538AAH01506710100BC001506 CD59 antigen p18-20Homo sapiens
(antigen identified by monoclonal
antibodies 16.3A5, EJ16, EJ30,
EL32 and G344)
1538X16447710100precursor polypeptide (AA −25 toHomo sapiens
103)
1538X17198710100CD59 antigen precursorHomo sapiens
1539AAH06290898100BC006290 chorionic gonadotropin,Homo sapiens
beta polypeptide
1539BC022796898100Unknown (protein for MGC: 39080)Homo sapiens
1539BC030994898100chorionic gonadotropin, betaHomo sapiens
polypeptide
1540J032251674100lipoprotein-associatedHomo sapiens
coagulation inhibitor precursor
1540M586501674100lipoprotein associatedHomo sapiens
coagulation inhibitor
1540M594991674100lipoprotein-associatedHomo sapiens
coagulation inhibitor
1540M594991674100lipoprotein-associatedHomo sapiens
coagulation inhibitor
1541AAH141671072100BC014167 Unknown (protein forHomo sapiens
MGC: 20892)
1541AAH208041072100BC020804 ribosomal protein L13Homo sapiens
1541BC0274631072100ribosomal protein L13Homo sapiens
1542AAH211361333100BC021136 Unknown (protein forHomo sapiens
MGC: 32056)
1542AF097362_11333100AF097362 gamma-interferonHomo sapiens
inducible lysosomal thiol
reductase
1542BC031020132999interferon, gamma-inducibleHomo sapiens
protein 30
1543AAH07008929100BC007008 crystallin, alpha BHomo sapiens
1543M28638929100alpha-B2-crystallinHomo sapiens
1543S45630929100alpha B-crystallinHomo sapiens
1544BC003775116999casein kinase II, beta subunitMus musculus
1544M304481174100casein kinase II beta subunitHomo sapiens
1544M59458116999casein kinase II beta subunitGallus
gallus
1545M77820620950fibronectinXenopus
laevis
1545X027611257099fibronectin precursorHomo sapiens
1545X15906730565precursor polypeptide (AA −32 toRattus
2445)norvegicus
1546BC032329274099cytochrome P450, subfamily XIAHomo sapiens
(cholesterol side chain cleavage)
1546M145652753100cholesterol side-chain cleavageHomo sapiens
enzyme P450scc (EC 1.14.15.67)
1546X05367273499desmolaseHomo sapiens
1547AF318372_159299AF318372 unknownHomo sapiens
1547AJ318881601100XAGE-3 proteinHomo sapiens
1547AJ318893601100XAGE-3 proteinHomo sapiens
1548AAH186412406100BC018641 eukaryotic translationHomo sapiens
elongation factor 1 alpha 1
1548AAH216862406100BC021686 eukaryotic translationHomo sapiens
elongation factor 1 alpha 1
1548BC0286742406100eukaryotic translation elongationHomo sapiens
factor 1 alpha 1
1549AAH070442377100BC007044 fibrinogen, gammaHomo sapiens
polypeptide
1549AAH216742377100BC021674 fibrinogen, gammaHomo sapiens
polypeptide
1549AF350254_12377100AF350254 fibrinogen gamma chain,Homo sapiens
isoform gamma-A precursor
1550AAH077852357100BC007785 Unknown (protein forHomo sapiens
IMAGE: 2819608)
1550AAH215652387100BC021565 Unknown (protein forHomo sapiens
MGC: 31904)
1550AF121858_12387100AF121858 sorting nexin 8Homo sapiens
1551AAH059291222100BC005929 proteoglycan 2, boneHomo sapiens
narrow (natural killer cell
activator, eosinophil granule
major basic protein)
1551X140881222100major basic protein precusor (AAHomo sapiens
1-222)
1551Y008091222100major basic preproprotein (AA −15Homo sapiens
to 207)
1552AL050169951100hypothetical proteinHomo sapiens
1552M34046951100placental protein 14 precursorHomo sapiens
(PP14)
1552M61886951100pregnancy-associated endometrialHomo sapiens
alpha2-globulin
1553AAH156412224100BC015641 enolase 1, (alpha)Homo sapiens
1553BC0225452224100enolase 1, (alpha)Homo sapiens
1553BC0277252224100enolase 1, (alpha)Homo sapiens
1554AF2721422649100cytochrome P450Homo sapiens
1554BC0325942649100cytochrome P450, subfamily IIJHomo sapiens
(arachidonic acid epoxygenase)
polypeptide 2
1554U371432649100cytochrome P450 monooxygenaseHomo sapiens
CYP2J2
1555AAH171231367100BC017123 ribosomal protein S3AHomo sapiens
1555AAH190721367100BC019072 ribosomal protein S3AHomo sapiens
1555BC0301611367100ribosomal protein S3AHomo sapiens
1556AB042200200488low-density lipoprotein receptor-Mus musculus
related protein 9
1556AL834518215499hypothetical proteinHomo sapiens
1556AX359701226899unnamed protein productHomo sapiens
1557BC040431510499glucosidase, alpha; acid (PompeHomo sapiens
disease, glycogen storage disease
type II)
1557M344245105100acid alpha-glucosidaseHomo sapiens
1557X550805105100acid alpha-glucosidaseHomo sapiens
1558AAH10914768100BC010914 Similar to hemoglobin,Homo sapiens
gamma G
1558BC029387768100hemoglobin, gamma GHomo sapiens
1558M91037768100G-gamma globinHomo sapiens
1559AY1481004568100colony stimulating factor 3Homo sapiens
receptor (granulocyte)
1559M598184568100granulocyte colony-stimulatingHomo sapiens
factor receptor
1559X557214568100granulocyte colony stimulatingHomo sapiens
factor receptor 25-1
1560AAH000131579100BC000013 insulin-like growthHomo sapiens
factor binding protein 3
1560AAH189621579100BC018962 insulin-like growthHomo sapiens
factor binding protein 3
1560M358781579100growth factor-binding protein-3Homo sapiens
precursor
1561M235951413100insulin-like growth factorHomo sapiens
binding protein 1
1561M593161413100insulin-like growth factorHomo sapiens
binding protein-1
1561X123851413100PP12 precorsor (AA −25 to 234)Homo sapiens
1562BC041218676100H3 histone, family 3BXenopus
laevis
1562M11393676100histone 3.3Gallus
gallus
1562Y00392676100histone H3.3B (AA 1-136)Gallus
gallus
1563AF523281191699MHC class Ib antigenHomo sapiens
1563AF523283191699MHC class Ib antigenHomo sapiens
1563M200221922100HLA-E class I protein precursorHomo sapiens
1564AAH035691980100BC003569 E74-like factor 3 (etsHomo sapiens
domain transcription factor,
epithelial-specific)
1564AF0173071980100Ets-related transcription factorHomo sapiens
1564AF110184_11980100AF110184 epithelium-restrictedHomo sapiens
Ets protein ESX
1565AF5233051810100MHC class Ib antigenHomo sapiens
1565AF5233061810100MHC class Ib antigenHomo sapiens
1565AF5233091810100MHC class Ib antigenHomo sapiens
1566AAH0950783699BC009507 Unknown (protein forHomo sapiens
MGC: 3945)
1566AY16864883699ubiquitin-like protein ISG15Homo sapiens
1566M1375583910017-kDa proteinHomo sapiens
1567AB033054256794KIAA1228 proteinHomo sapiens
1567AF099138135250GLUT4 vesicle proteinRattus
norvegicus
1567BC011482134850Similar to membrane bound C2Mus musculus
domain containing protein
1568AAH108531129100BC010853 Similar to integral typeHomo sapiens
I protein
1568AAH174951129100BC017495 integral type I proteinHomo sapiens
1568BC0222321129100integral type I proteinHomo sapiens
1569AF357203_1183297AF357203 MAP kinase phosphatase-1Rattus
norvegicus
1569BC0224631886100dual specificity phosphatase 1Homo sapiens
1569X682771886100protein-tyrosine phosphataseHomo sapiens
1570AAH09407687100BC009407 ribosomal protein S17Homo sapiens
1570AAH19899687100BC019899 ribosomal protein S17Homo sapiens
1570BC022370687100ribosomal protein S17Homo sapiens
1571AAH151051370100BC015105 proteasome (prosome,Homo sapiens
macropain) subunit, alpha type, 1
1571AAH153561370100BC015356 proteasome (prosome,Homo sapiens
macropain) subunit, alpha type, 1
1571BC0223721370100proteasome (prosome, macropain)Homo sapiens
subunit, alpha type, 1
1572AAH03352723100BC003352 tumor protein,Homo sapiens
translationally-controlled 1
1572BC022436723100Similar to tumor protein,Homo sapiens
translationally-controlled 1
1572X16064723100tumor protein (AA 1-172)Homo sapiens
1573BC0230063271100Unknown (protein for MGC: 30059)Homo sapiens
1573M270243271100heat shock proteinHomo sapiens
1573X15183327110090 kDa heat-shock protein (AA 1-732)Homo sapiens
1574AAH080642806100BC008064 monoamine oxidase AHomo sapiens
1574M688572806100monoamine oxidase AHomo sapiens
1574M692262806100monoamine oxidase AHomo sapiens
1575M843781952100lymphocyte antigenHomo sapiens
1575M84379194599MHC class I lymphocyte antigenHomo sapiens
1575Z27120194699HLA-A2 SLUHomo sapiens
1576BC0323501338100major histocompatibility complex,Homo sapiens
class II, DR alpha
1576M603341338100cell surface glycoproteinHomo sapiens
1576Z848141338100dJ172K2.4.1 (majorHomo sapiens
histocompatibility complex, class
II, DR alpha, isoform 1)
1577AAH02476803100BC002476 non-metastatic cells 2,Homo sapiens
protein (NM23B) expressed in
1577L16785803100c-myc transcription factorHomo sapiens
1577X58965803100NM23-H2 proteinHomo sapiens
1578AAH116451585100BC011645 Similar to Ras-relatedHomo sapiens
associated with diabetes
1578L245641585100RadHomo sapiens
1578U46165156599Rad GTPaseHomo sapiens
1579AAH033581151100BC003358 ribosonal protein L10Homo sapiens
1579BC0262761151100ribosomal protein L10Homo sapiens
1579L441401151100QMHomo sapiens
1580A845272912100unnamed protein productunidentified
1580AX0240422912100fusion between Aeguorea victoriasynthetic
and humanconstruct
1580M623992912100NF-kappa-B transcription factorHomo sapiens
1581AAH108602071100BC010860 serine (or cysteine)Homo sapiens
proteinase inhibitor, clade E
(nexin, plasminogen activator
inhibitor type 1), member 1
1581AF386492_12071100AF386492 serine-cysteineHomo sapiens
proteinase inhibitor clade E
member 1
1581X044292071100precursor polypeptideHomo sapiens
1582AAH004911316100BC000491 proliferating cellHomo sapiens
nuclear antigen
1582AF347680_11316100AF347680 proliferating cellMacaca
nuclear antigenfascicularis
1582AL1219241316100dJ746J20.2 (proliferating cellHomo sapiens
nuclear antigen)
1583AC0071652130100interleukin-1 receptor type IIHomo sapiens
1583AY1240102130100interleukin 1 receptor, type IIHomo sapiens
1583X597702130100type II interleukin-1 receptorHomo sapiens
1584BC0410712366100protein phosphatase 2 (formerlyHomo sapiens
2A), regulatory subunit B (PR
52), alpha isoform
1584M649292366100protein phosphatase-2A subunit-Homo sapiens
alpha
1584U093562366100protein phosphatase 2A1 B alphaOryctolagus
subunitcuniculus
1585M34421227999pregnancy-specific beta-1Homo sapiens
glycoprotein precursor
1585M34481227999pregnancy-specific beta-1-Homo sapiens
glycoprotein 11
1585M585912291100PSG11Homo sapiens
1586BC01825470397retinol binding protein 1,Mus musculus
cellular
1586M11433724100retinol-binding proteinHomo sapiens
1586X07437724100cellular retinol binding proteinHomo sapiens
1587J03149423783M-CSF receptorFelis catus
1587U639635158100CSF-1 receptorHomo sapiens
1587X03663515099put. c-fms precursorHomo sapiens
1588BC005580902100polymerase (RNA) II (DNAMus musculus
directed) polypeptide G
1588U52427902100RNA polymerase II seventh subunitHomo sapiens
1588Z71925902100RNA polymerase II RPB7 subunit-Rattus
like proteinnorvegicus
1589AAH11601658100BC011601 interferon, alpha-Homo sapiens
inducible protein (clone IFI-6-
16)
1589AAH15603658100BC015603 interferon, alpha-Homo sapiens
inducible protein (clone IFI-6-
16)
1589D1138465298ORFPan
troglodytes
1590AF1470831683100gamma-glutamyl hydrolaseHomo sapiens
1590BC0250251683100gamma-glutamyl hydrolaseHomo sapiens
(conjugase,
folylpolygammaglutamyl hydrolase)
1590U552061683100human gamma-glutamyl hydrolaseHomo sapiens
1591AAH104181552100BC010418 laminin receptor 1Homo sapiens
(67 kD, ribosomal protein SA)
1591AAH138271552100BC013827 laminin receptor 1Homo sapiens
(67 kD, ribosomal protein SA)
1591U43901155210037 kD laminin receptorHomo sapiens
precursor/p40 ribosome associated
protein
1592BC0260334101100gelsolin (amyloidosis, FinnishHomo sapiens
type)
1592X044124101100plasma gelsolinHomo sapiens
1592X13871384994gelsolinSus scrofa
1593AF304463_12813100AF304463 calcium transportHomo sapiens
protein CaT1
1593AF365927_12813100AF365927 calcium transportHomo sapiens
protein CaT1
1593AF365928_12946100AF365928 calcium transportHomo sapiens
protein CaT1
1594AY0405422353100sialic acid bindingHomo sapiens
immunoglobulin-like lectin 6
1594D863582353100CD33L1Homo sapiens
1594U71382224697OB binding protein-1Homo sapiens
1595AF286534_11115100AF286534 GTP-binding proteinRattus
RAB11Bnorvegicus
1595AF498947_11115100AF498947 small GTP bindingHomo sapiens
protein RAB11B
1595X79780111099YPT3Homo sapiens
1596BC010604125399ribosomal protein S6Mus musculus
1596BC0276201256100ribosomal protein S6Homo sapiens
1596Z54209125399rpS6Mus musculus
1597AJ005654703100secondary lymphoid tissueHomo sapiens
chemokine
1597BC027918703100small inducible cytokineHomo sapiens
subfamily A (Cys—Cys), member 21
1597U88320703100beta chemokine Exodus-2Homo sapiens
1598AF148856_2661398AF148856 unknownHomo sapiens
1598AF149422_2661598AF149422 unknownHomo sapiens
1598U935646714100putative p150Homo sapiens
1599AK0120131608100unnamed protein productMus musculus
1599BC003742160810026S proteasome-associated pad1Mus musculus
homolog
1599U86782160810026S proteasome-associated pad1Homo sapiens
homolog
1600BC041218676100H3 histone, family 3BXenopus
laevis
1600M11393676100histone 3.3Gallus
gallus
1600Y00392676100histone H3.3B (AA 1-136)Gallus
gallus
1601AAH11262271699BC011262 Unknown (protein forHomo sapiens
MGC: 18226)
1601AF00604327191003-phosphoglycerate dehydrogenaseHomo sapiens
1601AF171237_12719100AF171237 3-phosphoglycerateHomo sapiens
dehydrogenase
1602AF109197_11254100AF109197 nuclear chloride channelHomo sapiens
1602AJ012008125199RNCC proteinHomo sapiens
1602U932051254100nuclear chloride ion channelHomo sapiens
protein
1603BC0294021311100proteasome (prosome, macropain)Homo sapiens
subunit, alpha type, 3
1603BC038990130799Similar to proteasome (prosome,Homo sapiens
macropain) subunit, alpha type, 3
1603D00762130799proteasome subunit C8Homo sapiens
1604AB062400671100Similar to ribosomal protein S15aHomo sapiens
1604BC030569671100ribosomal protein S15aHomo sapiens
1604X77953671100ribosomal protein S15aRattus
norvegicus
1605AB0624381926100OK/SW-CL.30Homo sapiens
1605BC025832158190Unknown (protein for MGC: 37936)Mus musculus
1605BC036872191299Unknown (protein forHomo sapiens
IMAGE: 5225889)
1606AAH167062319100BC016706 eukaryotic translationHomo sapiens
initiation factor 3, subunit 6
(48 kD)
1606AAH216792319100BC021679 eukaryotic translationHomo sapiens
initiation factor 3, subunit 6
(48 kD)
1606BC0291772319100eukaryotic translation initiationMus musculus
factor 3, subunit 6 (48 kD)
1607AAH04138146599BC004138 ribosomal protein L6Homo sapiens
1607BC0310091475100ribosomal protein L6Homo sapiens
1607BC032299146599ribosomal protein L6Homo sapiens
1608AAH158132331100BC015813 eukaryotic translationHomo sapiens
elongation factor 1 gamma
1608BC0281792331100eukaryotic translation elongationHomo sapiens
factor 1 gamma
1608BC0310122331100eukaryotic translation elongationHomo sapiens
factor 1 gamma
1609AAH049271051100BC004927 Unknown (protein forHomo sapiens
MGC: 10432)
1609AF013711105110022 kDa actin-binding proteinHomo sapiens
1609D843421051100SM22 alphaHomo sapiens
1610AB00751012543100PRP8 proteinHomo sapiens
1610AB0473911246199pre-mRNA processing 8 proteinMus musculus
1610AF0925651247799splicing factor Prp8Homo sapiens
1611AAH100343127100BC010034 thyroid autoantigen 70 kDHomo sapiens
(Ku antigen)
1611AAH121543127100BC012154 Similar to thyroidHomo sapiens
autoantigen 70 kD (Ku antigen)
1611AAH182593127100BC018259 thyroid autoantigen 70 kDHomo sapiens
(Ku antigen)
1612AL050369249299hypothetical proteinHomo sapiens
1612AY0408222500100U4/U6 snRNP-associated 61 KDaHomo sapiens
protein
1612BC018376247998Unknown (protein for MGC: 19247)Mus musculus
1613AF343440_145498AF343440 lysosomal H+Canis
transporting-ATPase subunit M9.2familiaris
1613AX400012459100unnamed protein productHomo sapiens
1613Y15286459100vacuolar proton-ATPase subunitHomo sapiens
M9.2
1614AAH01273183199BC001273 galactose-4-epimerase,Homo sapiens
UDP-
1614AF0223821835100UDP-galactose 4′ epimeraseHomo sapiens
1614L416681835100UDP-galactose-4-epimeraseHomo sapiens
1615AAH0527090099BC005270 NADH dehydrogenaseHomo sapiens
(ubiquinone) Fe-S protein 4
(18 kD) (NADH-coenzyme Q
reductase)
1615AF020351904100NADH: ubiquinone oxidoreductase 18 kDaHomo sapiens
IP subunit
1615X6321583990NADH dehydrogenaseBos taurus
1616AAH04963674100BC004963 ATP synthase, H+Homo sapiens
transporting, mitochondrial F0
complex, subunit c (subunit 9),
isoform 1
1616AL080089674100hypothetical proteinHomo sapiens
1616X69907674100P1 gene for c subunit of humanHomo sapiens
mitochondrial ATP synthase
1617AF100620_11492100AF100620 transcription factor-Homo sapiens
like protein MRGX
1617AF167174_11492100AF167174 MSL3-2 proteinHomo sapiens
1617AL0496101492100dJ1055C14.2 (KIAA0026Homo sapiens
(transcription factor-like
protein MRGX))
1618AAH15557185499BC015557 Unknown (protein forHomo sapiens
MGC: 1567)
1618BC021637114066CD68 antigenMus musculus
1618S572351858100CD68Homo sapiens
1619L276314010100amyloid precursor-like protein 2Homo sapiens
1619S600994010100APPHHomo sapiens
1619Z225724010100CDEI binding proteinHomo sapiens
1620AAH08850127399BC008850 Unknown (protein forHomo sapiens
MGC: 14308)
1620AAH09599127399BC009599 Unknown (protein forHomo sapiens
MGC: 14690)
1620L165581276100ribosomal protein L7Homo sapiens
1621AF06248284599SDP3Mus musculus
1621AF062483852100SDP3Homo sapiens
1621AF52042083898sorting nexin 3Mus musculus
1622AF0636576995100vascular endothelial growthHomo sapiens
factor receptor
1622D28498588282Fit-1 tyrosine kinase receptorRattus
norvegicus
1622X51602698999flt gene product (AA 1-1338)Homo sapiens
1623AF149422_270349AF149422 unknownHomo sapiens
1623U9357271050putative p150Homo sapiens
1623U9357470949putative p150Homo sapiens
1624AF0297293066100neuralizedHomo sapiens
1624BC026336304199neuralized-like (Drosophila)Homo sapiens
1624U878643066100neuralized homologHomo sapiens
1625AAH20782643100BC020782 glycoprotein hormones,Homo sapiens
alpha polypeptide
1625J00152643100glycoprotein alpha subunitHomo sapiens
1625V00518643100chorionic gonadotropinHomo sapiens
1626AAH027222070100BC002722 guanine nucleotideHomo sapiens
binding protein (G protein),
alpha stimulating activity
polypeptide 1
1626AF493897_12070100AF493897 guanine nucleotideHomo sapiens
binding protein alpha s long
1626X044082070100alpha-S2 (aa 1-394)Homo sapiens
1627BC0337141724100heterogeneous nuclearHomo sapiens
ribonucleoprotein A1
1627D867291724100TISMus musculus
1627M991671724100RNA binding proteinMus musculus
1628AF0728361827100Sox-like transcriptional factorHomo sapiens
1628AF146223_1620100AF146223 HMG domain protein HMGX2Homo sapiens
1628AF288679620100smarcel-related proteinHomo sapiens
1629AAH219791360100BC021979 ribosomal protein L7aHomo sapiens
1629BC0325331360100ribosomal protein L7aHomo sapiens
1629X150131360100ribosomal protein L7a (AA 1-266)Rattus
Rattus
1630X51538693100ribosomal protein S24 (AA 1-133)Rattus
Rattus
1630X52445693100ribosomal protein S24Rattus
norvegicus
1630X52658693100ribosomal protein S19 (AA 1-133)Mesocricetus
auratus
1631AAH015032789100BC001503 prosaposin (variantHomo sapiens
Gaucher disease and variant
metachromatic leukodystrophy)
1631AAH042752789100BC004275 prosaposin (variantHomo sapiens
Gaucher disease and variant
metachromatic leukodystrophy)
1631AAH076122789100BC007612 prosaposin (variantHomo sapiens
Gaucher disease and variant
metachromatic leukodystrophy)
1632AAH117761369100BC011776 Similar to tropomyosin 2Homo sapiens
(beta)
1632M748171369100tropomyosin-1Homo sapiens
1632M751651369100tropomyosinHomo sapiens
1633AL023883117399dJ404K8.1 (prolactin)Homo sapiens
1633BC0158501185100similar to prolactin precursorHomo sapiens
1633V005661185100reading frame prolactinHomo sapiens
1634AK01260124764unnamed protein productMus musculus
1634AK02140928669unnamed protein productMus musculus
1634AK07580124664unnamed protein productMus musculus
1635AF300943_1946894AF300943 tyrosine phosphatase LARMus musculus
1635L11586948495leukocyte common antigen-relatedRattus
phosphatasenorvegicus
1635Y008159953100put. LAR preprotein (AA −16 toHomo sapiens
1881)
1636AAH160462739100BC016046 ATP synthase, H+Homo sapiens
transporting, mitochondrial F1
complex, alpha subunit, isoform
1, cardiac muscle
1636AAH193102739100BC019310 ATP synthase, H+Homo sapiens
transporting, mitochondrial F1
complex, alpha subunit, isoform
1, cardiac muscle
1636X654602739100ATP synthase alpha subunitHomo sapiens
1637AF237581_1613100AF237581 migration inhibitoryHomo sapiens
factor-related protein 14 variant P
1637M26311613100cystic fibrosis antigenHomo sapiens
1637X06233613100MRP-14 (AA 1-114)Homo sapiens
1638AAH1549252396BC015492 Unknown (protein forHomo sapiens
MGC: 8967)
1638BC03262628064TLH29 protein precursorHomo sapiens
1638X67325556100ISG12Homo sapiens
1639L001602135100phosphoglycerate kinaseHomo sapiens
1639M119682135100phosphoglycerate kinaseHomo sapiens
1639V005722135100coding sequenceHomo sapiens
1640AF07557511112100dysferlinHomo sapiens
1640AF188290_11035593AF188290 dysferlinMus musculus
1640AK074104793998FLJ00175 proteinHomo sapiens
1641AB05222910414100RNA polymerase II largest subunitCricetulus
griseus
1641D8729410414100RNA polymerase II largest subunitCricetulus
griseus
1641X6356410414100RNA polymerase II largest subunitHomo sapiens
1642AF070650844100F1F0-type ATP synthase subunit dHomo sapiens
1642AF087135844100F1FO-type ATPase subunit dHomo sapiens
1642BC038092844100ATP synthase, H+ transporting,Homo sapiens
mitochondrial F0 complex, subunit d
1643U01153404697GRP94Canis
familiaris
1643X151874112100precursor polypeptide (AA −21 toHomo sapiens
782)
1643Y09136403897gp96/GRP94Sus scrofa
1644AF297036_1670100AF297036 ubiquitin fusion proteinOphiophagus
hannah
1644BC014772670100ubiquitin A-52 residue ribosomalMus musculus
protein fusion product 1
1644M24508670100ubiquitinsynthetic
construct
1645AK00038521144unnamed protein productHomo sapiens
1645AK09708524551unnamed protein productHomo sapiens
1645AK09721420159unnamed protein productHomo sapiens
1646AF100956782100ribosomal protein subunit S18Mus musculus
1646AF110520782100RPS18Mus musculus
1646M76763782100ribosomal proteinMus musculus
1647BC025077930100RIKEN cDNA 2010203J19 geneMus musculus
1647L05092930100ribosomal protein L11Homo sapiens
1647X62146930100ribosomal protein L11Rattus
Rattus
1648AB037890679599pre-mRNA splicing factor SF3b 155 kDaMus musculus
subunit
1648AF0542846808100spliceosomal protein SAP 155Homo sapiens
1648Y08997656696146 kDa nuclear proteinXenopus
laevis
1649AF072097624100beta-2 microglobulinHomo sapiens
1649AY007153624100similar to Homo sapiens mRNA for
beta 2-microglobulin with GenBank
Accession Number AB021288
1649BC032589624100beta-2-microglobulinHomo sapiens
1650AAH178391602100BC017839 caspase 4, apoptosis-Homo sapiens
related cysteine protease
1650U289771769100Mih1/TX isoform betaHomo sapiens
1650U289781602100Mih1/TX isoform gammaHomo sapiens
1651AAH07967974100BC007967 Unknown (protein forHomo sapiens
MGC: 14460)
1651AAH12149974100BC012149 Unknown (protein forHomo sapiens
MGC: 20365)
1651BC031906974100similar to ribosomal protein L9;Homo sapiens
60S ribosomal protein L9
1652BC002145745100ribosomal protein S23Mus musculus
1652D14530745100ribosomal proteinHomo sapiens
1652X77398745100ribosomal protein S23Rattus
norvegicus
1653AF227256_1405100AF227256 NEDD8Bos taurus
1653BC00462539898neural precursor cell expressed,Mus musculus
developmentally down-regulated
gene 8
1653D23662405100ubiquitin-like proteinHomo sapiens
1654U46034207683stromelysin 3Rattus
norvegicus
1654X577662679100stromelysin-3 precursorHomo sapiens
1654Z12604216481stromelysin-3Mus musculus
1655AAH01734499100BC001734 protein translocationHomo sapiens
complex beta
1655AL137067499100bA13B9.2 (novel protein similarHomo sapiens
to the beta subunit of transport
protein SEC61)
1655L25085499100Sec61-complex beta-subunitHomo sapiens
1656AF165522_1360100AF165522 ras-related GTP-bindingHomo sapiens
protein 4b
1656AF217985_1360100AF217985 unknownHomo sapiens
1656AF498935_1360100AF498935 small GTP bindingHomo sapiens
protein RAB4B
1657AF006602543694histone deacetylase mHDA1Mus musculus
1657AF132608_15784100AF132608 histone deacetylase 5Homo sapiens
1657AF207748_1543194AF207748 histone deacetylase 5Mus musculus
1658AL0502594009100hypothetical proteinHomo sapiens
1658BC0326814009100RAB2, member RAS oncogene family-Home sapiens
like
1658Z971844009100cICF0811.4.1 (RAB2, member RASHomo sapiens
oncogene family-like, isoform 1)
1659AF151855_11278100AF151855 CGI-97 proteinHomo sapiens
1659AK001779121496unnamed protein productHomo sapiens
1659BC003849120094RIKEN cDNA 4733401P19 geneMus musculus
1660AAH002341377100BC000234 nicotinamide N-Homo sapiens
methyltransferase
1660U080211377100nicotinamide N-methyltransferaseHomo sapiens
1660U209711377100nicotinamide N-methyltransferaseHomo sapiens
1661AAH031371240100BC003137 ribosomal protein S3Homo sapiens
1661BC0341491240100ribosomal protein S3Homo sapiens
1661U149921240100ribosomal protein S3Homo sapiens
1662AF090891_1391399AF090891 PRO0105Homo sapiens
1662AF268075_1391399AF268075 TRAF6-binding proteinHomo sapiens
T6BP
1662U338213924100tax1-binding protein TXBP151Homo sapiens
1663AF186112_1619100AF186112 neurokinin B-likeHomo sapiens
protein ZNEUROK1
1663AF216586_1619100AF216586 neurokinin BHomo sapiens
1663BC032145619100tachykinin 3 (neuromedin K,Homo sapiens
neurokinin beta)
1664AAH08405204490BC008405 Unknown (protein forHomo sapiens
MGC: 14528)
1664M94891204290pregnancy-specific beta-1Homo sapiens
glycoprotein
1664U184672252100pregnancy-specific beta 1-Homo sapiens
glycoprotein 7 precursor
1665AK00298998093unnamed protein productMus musculus
1665D38076104199Ran-BP1 (Ran-binding protein 1)Homo sapiens
1665X836171057100RanBP1Homo sapiens
1666AF1526043398100bromodomain-containing proteinHomo sapiens
1666AF213969336999bromodomain protein CELTIX1Homo sapiens
1666AJ2718813398100bromodomain containing proteinHomo sapiens
1667AF217973_132968AF217973 unknownHomo sapiens
1667AK00049633066unnamed protein productHomo sapiens
1667AK09051135264unnamed protein productHomo sapiens
1668AK0009172276100unnamed protein productHomo sapiens
1668BC025560215694Similar to hypothetical proteinMus musculus
FLJ10055
1668BC039867225999hypothetical protein FLJ10055Homo sapiens
1669AB0398861071100down-regulated in gastric cancerHomo sapiens
1669AY13918299510018 kDa antrum mucosa proteinHomo sapiens
1669AY13918499510018 kDa antrum mucosa proteinHomo sapiens
1670BC033721354099Unknown (protein for MGC: 45264)Homo sapiens
1670X821573543100hevinHomo sapiens
1670X86693350499Hevin-like proteinHomo sapiens
1671M84472167510017-beta-hydroxysteroidHomo sapiens
dehydrogenase
1671U34879167510017-beta-hydroxysteroidHomo sapiens
dehydrogenase
1671X13440167510017-HSD protein (AA 1-328)Homo sapiens
1672AAH12612181299BC012612 Similar to cathepsin LHomo sapiens
1672M204961816100preprocathepsin L precursorHomo sapiens
1672X124511816100pro-(cathepsin L)Homo sapiens
1673AAH123553449100BC012355 Similar to soluteHomo sapiens
carrier family 6
(neurotransmitter transporter,
creatine), member 8
1673U363413449100creatine transporterHomo sapiens
1673Z665393449100creatine transporterHomo sapiens
1674AF267852_1749100AF267852 placental protein 13-Homo sapiens
like protein
1674AF367430571100placental protein 13-likeHomo sapiens
1674BC02225773198Similar to placental protein 13-Homo sapiens
like protein
1675AB001636407299ATP-dependent RNA helicase #46Homo sapiens
1675AF279891_14162100AF279891 dead box protein 15Homo sapiens
1675BC0359744162100DEAD/H (Asp-Glu-Ala-Asp/His) boxHomo sapiens
polypeptide 15
1676AAH17321687100BC017321 Unknown (protein forHomo sapiens
MGC: 29768)
1676BC002079687100Similar to ribosomal protein S12Mus musculus
1676BC018362687100Unknown (protein for MGC: 19264)Mus musculus
1677AAH20619112399BC020619 glutathione S-Homo sapiens
transferase A3
1677AF508266_11127100AF508266 glutathione transferaseHomo sapiens
A3-3
1677AL1219691127100dJ214M20.1 (glutathione S-Homo sapiens
transferase A3)
1678AAH00359923100BC000359 signal peptidase complexHomo sapiens
(18 kD)
1678AAH14508923100BC014508 Similar to signalHomo sapiens
peptidase complex (18 kD)
1678AF061737923100microsomal signal peptidaseHomo sapiens
1679AF179890_1598100AF179890 DNA polymerase deltaHomo sapiens
smallest subunit p12
1679AF515709_149283AF515709 small subunit DNAMus musculus
polymerase delta p12
1679BC02852049283Unknown (protein for MGC: 41275)Mus musculus
1680AC005067_2134073AC005067 Supported by Human ESTHomo sapiens
H08032.1 (NID: g872854), mouse EST
AA870042.1 (NID: g2965487), and
genscan
1680AF226732_12286100AF226732 NPD007Homo sapiens
1680BC018360119968Unknown (protein for MGC: 18730)Mus musculus
1681AAH19040897100BC019040 Unknown (protein forHomo sapiens
MGC: 20769)
1682AK023767960100unnamed protein productHomo sapiens
1682AL080169979100hypothetical proteinHomo sapiens
1682BC016647960100Unknown (protein for MGC: 16844)Homo sapiens
1683AF309646_1114788AF309646 Rab6-like protein WTH3Homo sapiens
1683AF498941_11058100AF498941 small GTP bindingHomo sapiens
protein RAB6C
1683AL136727114788hypothetical proteinHomo sapiens
1684AC005095_11373100AC005095 pantophysinHomo sapiens
1684S724811373100pantophysinHomo sapiens
1684X681941373100h-Sp1Homo sapiens
1685D14665385099KIAA0021 proteinHomo sapiens
1685U41765381483metalloprotease/disintegrin/cysteineMus musculus
rich protein precursor
1685U417664476100metalloprotease/disintegrin/cysteine-Homo sapiens
rich protein precursor
1686U207701412100cell surface glycoproteinHomo sapiens
1686U672741412100metastasis suppressorHomo sapiens
1686X537951412100inducible nembrane proteinHomo sapiens
1687AF517934_12980100AF517934 interleukin 2 receptor,Homo sapiens
beta
1687AL0223142980100dJ1170K4.3 (Interleukin 2Homo sapiens
Receptor, Beta (IL-2 Receptor,
CD122 antigen))
1687BC0256912980100interleukin 2 receptor, betaHomo sapiens
1688AF0722422167100methyl-CpG binding protein MBD2Homo sapiens
1688AF1209942167100methyl-CpG binding protein 2Homo sapiens
1688BC0326382167100nethyl-CpG binding domain protein 2Homo sapiens
1689AAH00486607100BC000486 small nuclearHomo sapiens
ribonucleoprotein D2 polypeptide
(16.5 kD)
1689AAH01930607100BC001930 small nuclearHomo sapiens
ribonucleoprotein D2 polypeptide
(16.5 kD)
1689AC00719_1607100AC007191 SMD2_HUMAN; SNRNP COREHomo sapiens
PROTEIN D2; SM-D2
1690AAH18180870100BC018180 CGI-121 proteinHomo sapiens
1690AF151879_1870100AF151879 CGI-121 proteinHomo sapiens
1690BC029492870100CGI-121 proteinHomo sapiens
1691U52373406399MNBHomo sapiens
1691U58497403799mp86Mus musculus
1691X79769405299Dual Specificity Yak1-relatedRattus
Kinase (Dyrk)norvegicus
|
Example 3
Initial Determination of Differential Regulation of Polynucleotides of the Invention in Pre-Eclampsia
A plurality of polynucleotide sequences were obtained from cDNA libraries obtained from both normal and pre-eclamptic placental tissues, us9ing SBH sequence signature analysis and Sanger sequencing techniques. The inserts of the library were amplified with PCR using primers specific for the vector sequences which flank the inserts. Clones from cDNA libraries were spotted on nylon membrane filters and screened with oligonucleotide probes (for example, 7-mers) to obtain signature sequences. The clones were clustered into groups of similar or identical sequences. Representative clones were selected for sequencing.
In some cases, the 5′ sequences of the amplified inserts was then deduced using a typical Sanger sequencing protocol. PCR products were purified and subjected to fluorescent dye terminator cycle sequencing. Single pass gel sequencing was done using a 377 Applied Biosystems (ABI) sequencer to obtain the novel nucleic acid sequences. In some cases, RACE (Rapid Amplification of cDNA Ends) was performed to further extend the sequence in the 5′ direction.
Relative expression of the gene may be approximated by a relative abundance of a transcript (number of copies of mRNA) of the gene in question in the cytoplasm of the cells of the tissues in question. Relative abundance of a transcript is calculated as an absolute number of cDNA clones from that transcript in the library created from the total mRNAs of the analyzed tissue over a total number of cDNA clones analyzed per tissue (e.g. 100,000 was the total number of cDNA clones analyzed per tissue. For example, if a gene was represented by 25,000 clones in a given placental library—i.e. it's cDNA cluster comprised 25,000 clones, relative expression of that gene is 25%, since 25% of all clones analyzed belong to that one gene.
Differential expression may be calculated for heterogeneous cDNA clusters which are clusters obtained through clustering of clones from two or more different libraries together. A cluster may be heterogeneous even if it's made up of clones from one library only, provided clustering was done for more than one library. More precisely, heterogeneity is the qualifier of the clustering experiment, rather that the qualifier of the cluster. For example, if two or more libraries were used in the clustering experiment, and a cluster comprises clones from only one of the two libraries, it can still be characterized as heterogeneous, with zero clones from all but one libraries. In this case pairwise comparisons were performed where two libraries were clustered at a time. For given initial conditions (100,000 clones per library, 200,000 total per clustering experiment), clusters of a size of 8 clones or greater were selected for further consideration. Out of these only those showing a differential ratio of clones of 2 times and above were selected as of statistically significant differential expression, thus keeping the confidence level at greater than or equal to 90%. This number measures the probability that the given cluster shows real differential expression. Note that since both libraries in the pair at hand were of the same initial size, therefore, no normalization of the cluster size on the total library size was necessary.
The following table shows the results of this process, indicating which polynucleotides of the invention are designated as up-regulated in pre-eclamptic placental tissues, and which are down-regulated in pre-eclamptic placental tissues.
TABLE 2
|
|
Expression
Expressionin Pre-
SEQ IDin Normaleclamptic
NO:REGULATIONCluster_IDPlacentaPlacenta
|
|
1UP434711
2UP376108148
3UP6623610
4UP1996615
5UP129511732
6UP47041823
7UP393008
8UP121382529
9UP703126212
10DOWN305190180
11DOWN828781125
12UP24982040
13DOWN1270080
14DOWN67792810
15DOWN103793
16UP823818
17UP110511012
18DOWN9165221
19DOWN826592
20DOWN3985280
21DOWN13238161
22UP318429
23DOWN15366432
24DOWN3247081
25DOWN6195161
26UP69314
27DOWN1550144
28DOWN154493
29DOWN31292318
30DOWN39826110
31DOWN39825110
32DOWN122374226
33DOWN39614140
34DOWN2222381
35DOWN827482
36DOWN8993161
37DOWN16337111
38DOWN59591816
39DOWN39367101
40DOWN7336234
41UP10522273
42DOWN6260181
43DOWN778280
44DOWN1405780
45UP54381427
46DOWN9433152
47DOWN9442188
48DOWN17223610
49DOWN2710319
50DOWN102451411
51DOWN24399152
52UP4592210
53DOWN9466233
54DOWN4089390
55DOWN963991
56DOWN7143101
57UP5712045
58UP396230
59UP11951017
60UP665629
61UP2970210
62DOWN29292118
63DOWN105563717
64DOWN10335542
65UP1152862
66UP19071822
67UP326532
68UP46571230
69UP222878145
70UP306128
71UP214555154
72UP40722131
73DOWN1017715
74DOWN13071918
75UP2602123
76UP26751655
77UP51312839
78DOWN26632016
79DOWN34855612
80UP41893043
81DOWN2880197
82UP3514835
83UP11842492
84DOWN1047205
85UP373376
86DOWN2085174
87UP2655116
88DOWN1300781
89UP920325
90DOWN507111
91DOWN34139725
92UP3610517
93DOWN3705102
94DOWN303181
95DOWN6875141
96UP47912933
97UP1514510
98UP848629
99DOWN1305277
100UP26592979
101DOWN44983714
102UP141681318
103DOWN339181
104UP30131015
105UP1182232
106DOWN11771037
107UP5258411
108DOWN1739201
109UP951030
110UP6641920
111UP1234118
112UP9914119
113UP1682353
114DOWN14923211
115DOWN7692623
116UP87616
117UP1314127
118DOWN1147126100
119UP4205623
120DOWN2994199
121UP8432136
122UP1220412
123DOWN482233
124UP106129
125UP22051042
126DOWN17302118
127DOWN59835111
128UP105592394
129DOWN2158285
130UP25213135
131DOWN49563827
132DOWN7031172
133DOWN167091
134DOWN30049232
135DOWN2795580
136DOWN767981
137UP2741915
138DOWN7542114
139UP817969
140UP7089414
141UP69681317
142UP7166334
143UP7378934
144DOWN6954255
145DOWN3051161
146DOWN5485145
147UP5128625
148UP6749418
149DOWN50701511
150UP1059810
151UP48851821
152UP464330100
153DOWN5058159
154UP5980521
155UP2089611
156DOWN54902822
157UP48215295
158UP611327
159UP4710737
160DOWN808381
161UP4878943
162DOWN18572521
163DOWN5346113
164UP51242155
165UP480441123
166DOWN6555103
167DOWN686982
168DOWN7961138
169DOWN68545813
170UP13272315
171UP47966685
172UP2581213
173UP533419
174UP10290024
175DOWN5245375
176DOWN1252182
177UP138279148
178DOWN1256690
179UP6354710
180UP49451465
181DOWN54917225
182DOWN10400222
183UP5702725
184DOWN30502217
185DOWN6201209
186UP4884327
187DOWN772581
188UP59884371
189UP11831316
190DOWN4855163
191UP7862527
192UP5263419
193UP55561620
194UP775818
195UP9188117
196DOWN46981816
197UP565408
198UP4937310
199UP5890218
200UP3983546
201DOWN72404519
202UP555538
203UP527649
204DOWN66874922
205UP35473193
206UP35131454
207DOWN1044681
208UP10774813
209UP1079317
210DOWN10988261
211UP436618
212DOWN624311996
213DOWN724880
214UP8984210
215UP561526
216DOWN106571311
217UP9847512
218UP10184914
219UP5279616
220UP12109822
221UP3955716
222UP8885210
223UP10365221
224UP1178530
225UP4066517
226UP17601111
227UP59691245
228DOWN488381
229UP51631738
230UP1073938
231DOWN125075217
232DOWN18123530
233UP134018
234DOWN3197102
235UP9077812
236DOWN100162117
237UP3788311
238DOWN1001181
239UP959939
240DOWN6566641
241DOWN9865191
242UP108851726
243UP12292522
244DOWN123904522
245DOWN13573494
246DOWN1203354
247UP97681933
248UP6552312
249DOWN1036394
250UP6491527
251UP12635010
252DOWN464176
253DOWN12809212
254UP28681134
255DOWN64231367
256UP8249613
257DOWN46652414
258DOWN35211817
259UP30011825
260DOWN1174082
261UP13122516
262UP21774872
263UP84441124
264DOWN2187575
265UP696261148
266DOWN1253872
267UP4434467
268DOWN13257145
269DOWN13549190
270DOWN4087112
271UP45320
272DOWN12290139
273UP35701149
274UP714229
275DOWN135963712
276UP197534251
277DOWN901166
278UP565277107
279DOWN10591112
280DOWN1191092
281UP12090626
282DOWN449516733
283UP3739532
284UP5064218
285DOWN10511232
286UP175029
287DOWN2968164
288UP12172731
289UP11685913
290UP12822414
291UP4732912
292UP1297118
293UP1218048
294UP6618813
295DOWN12247234
296UP90861023
297UP117652033
298UP12767238
299DOWN21361312
300UP111018
301UP100992675
302DOWN4800102
303DOWN1365281
304UP4762313
305UP151908
306UP223117
307UP1368018
308UP1188418
309DOWN16811613
310UP118001636
311UP6565111125
312UP13555911
313DOWN7878154
314DOWN11630123
315DOWN85962912
316DOWN8005178
317DOWN50372912
318UP6442938
319UP719017
320UP12055926
321DOWN4714449
322UP4330210
323UP67731453
324DOWN90578126
325DOWN290791
326UP2910317
327DOWN9989103
328UP171328
329UP36182367
330UP2252617
331DOWN12013132
332UP66732438
333DOWN20916411
334DOWN115394328
335DOWN1430581
336UP88351453
337DOWN12824155
338DOWN13661145
339UP82902224
340DOWN1255981
341UP101922134
342UP8540317
343DOWN563188
344UP5319311
345DOWN11311913
346DOWN100342518
347UP1064408
348DOWN65641510
349UP656510
350DOWN134651611
351DOWN13564208
352UP91102661
353DOWN65948042
354UP16371344
355UP13262326
356UP4841669
357DOWN103146311
358DOWN988080
359DOWN10993174
360UP5788718
361DOWN989210954
362UP16023883
363UP11912144
364DOWN12812547
365UP239166949
366DOWN120211190
367DOWN3724223
368UP108019
369UP23763394
370UP190508774
371UP38661165
372DOWN27995121
373UP419917
374UP311221
375DOWN35852014
376DOWN658392
377UP5646933
378UP4746127
379DOWN8891332
380UP13605813
381UP447916118
382UP752329
383UP7575116
384DOWN4842183
385UP20713172
386UP6828124
387UP99731838
388DOWN214110461
389UP90031016
390DOWN12691252
391DOWN13237196
392UP22018
393UP53711033
394UP127232539
395DOWN99543113
396UP14614851
397DOWN10742102
398UP51892354
399UP28622197
400UP1288819
401UP8225421
402DOWN5829165
403DOWN12383631
404UP22345055
405UP10464513
406UP14391619
407DOWN63533917
408UP8356812
409UP12863318
410UP53911417
411DOWN660293
412UP12828319
413DOWN6367161
414UP76411630
415UP10503210
416UP36871017
417DOWN55243715
418DOWN152577450
419DOWN6087117
420DOWN3375613
421UP381124
422UP19405567
423DOWN1002227
424DOWN19222210
425DOWN61925824
426UP20413360
427DOWN9351311
428UP17581016
429UP2954835
430UP40973466
431DOWN487827
432DOWN6228258
433UP2354599
434UP6902448
435UP1362428
436UP19784893
437UP69128
438DOWN3805111
439UP363998115
440DOWN691981
441DOWN5858435
442DOWN4436181
443UP89232731
444UP24226377
445UP121167106
446DOWN547380
447UP380218454
448DOWN2785136
449UP60901616
450UP1772334
451DOWN36322511
452UP6400210
453DOWN16604913
454UP19342495
455UP2680112
456UP1361091
457DOWN944530647
458DOWN47638243
459DOWN10684033
460DOWN17973219
461DOWN8275562
462UP26508
463UP6547211
464UP92441236
465UP5676915
466UP964367
467UP6047326
468UP355919
469UP618249
470DOWN837713958
471UP12651348
472DOWN12747155
473DOWN14061215
474UP36589367
475UP23636888
476UP101951418
477DOWN45204212
478DOWN12435123
479UP884922
480UP4138518
481UP1154319
482UP27784771
483DOWN8521615
484DOWN718811020
485DOWN1216891
486UP11591115
487UP10039212
488UP51941132
489UP1006117
490DOWN19943020
491UP11941878
492DOWN5733128
493DOWN1299124
494UP86925
495UP292123155
496UP3644119
497DOWN114581913
498UP1264117
499DOWN11674759
500UP308908
501DOWN855293
502DOWN4808251
503UP65401633
504UP39661333
505DOWN886102
506UP31672325
507UP1246412
508UP30182325
509UP50628
510UP4683420
511UP11654178
512DOWN814880
513UP574649
514DOWN8658374
515UP32351837
516DOWN5271615
517DOWN46053822
518UP5176495
519UP13412335
520DOWN88583213
521DOWN8205101
522UP69771222
523DOWN12678159
524DOWN931248
525DOWN129473811
526UP89551739
527DOWN941881
528UP111329129
529DOWN36172523
530UP52431014
531UP42462249
532UP8909531
533UP12131849
534UP13318210
535UP57417
536DOWN916691
537UP6211537
538UP2771115
539UP3413874
540DOWN468820484
541UP321917
542UP60561432
543DOWN67399765
544UP629172487
545UP323962106
546DOWN495810965
547DOWN2735143
548UP6224440
549UP3142623
550DOWN20985734
551UP155425128
552UP2424213
553UP12728
554DOWN212283
555UP4776410
556DOWN327181
557UP12520110
558DOWN4604114
559DOWN9810161
560UP360011
561DOWN1086791
562UP191297214
563DOWN751123120
564UP17533250
565DOWN5049166
566UP65115329
567UP26091742
568UP11967516
569UP92301230
570UP39463396
571UP7522158
572UP476712127
573DOWN995881
574UP113391100
575UP508718
576UP12332912
577UP3831145
578UP10259418
579DOWN5245121
580DOWN11813469
581DOWN606081
582DOWN923196162
583DOWN661981
584DOWN41501610
585UP41852530
586UP37641619
587DOWN11835478
588UP2221639
589UP393737
590UP43522690
591UP53843050
592DOWN30192016
593UP5001417
594UP33701431
595DOWN70692419
596DOWN51265933
597UP3532210
598UP1216452225
599UP1932122
600UP80862024
601UP258647299
602UP87802372
603DOWN139284522
604DOWN11269241
605DOWN70705837
606UP15574297
607UP11999519
608UP116612233
609DOWN70650611
610DOWN4982016
611DOWN9171613
612UP8974811
613UP2067105268
614UP2443817
615UP915398
616UP1585934
617DOWN12831410
618UP197759112
619DOWN653581
620UP94171932
621DOWN89591817
622UP8095322
623DOWN1046881
624UP66641318
625DOWN2971154
626UP43861950
627DOWN384332116
628UP622329
629DOWN9914124
630DOWN326181
631UP125111248
632UP188328
633UP1918332
634DOWN9695634
635UP88821028
636DOWN2315300277
637UP12863346
638UP600481149
639UP22364483
640UP1240029
641DOWN67161307
642UP371599
643DOWN69312014
644DOWN52788213
645UP7811115
646DOWN378312476
647DOWN7244234
648UP1353017
649UP66619
650UP741323
651DOWN70024021
652DOWN9722147
653DOWN8831111
654UP1002563
655UP185101105
656UP1305028
657UP1215161339
658UP14932742
659UP2647011
660UP1186529
661UP335229
662DOWN997491
663UP432508
664UP5859925
665DOWN1075572
666DOWN8227277
667UP3716746
668UP3304524
669UP3045312
670DOWN2017132
671DOWN1299480
672UP238654111
673DOWN88849811
674UP39493058
675DOWN119712119
676DOWN808081
677UP19323771
678UP173518
679UP10004514
680UP231328
681UP4131225
682UP82451102
683UP549487133
684UP118421149
685UP8881738
686DOWN99042713
687UP61414273
688DOWN493318033
689DOWN4859125
690DOWN75685535
691DOWN105054427
692DOWN23833420
693UP18220653955
694DOWN612914340
695UP10187921
696UP3647666
697UP3315810
698DOWN12014174
699UP129547028
700UP120616233
701UP28213083
702UP1188229
703UP60889201
704DOWN2261202
705UP77282526
706UP535583991
707DOWN5075660
708DOWN170980
709UP20581019
710UP89131433
711DOWN2605233
712DOWN638880
713UP39829125
714UP1461754
715UP4257812
716UP56261421
717UP209931123
718UP91422425
719UP117441429
720UP1231981192
721UP27753383
722UP294929
723UP32445397
724UP153316
725UP10341148
726DOWN3515146
727UP143138265
728DOWN9234103
729DOWN6026483
730UP5906926
731UP12881323
732UP91519
733DOWN989192
734UP3340272
735DOWN115717413
736UP1023220
737DOWN6706159
738UP5187929
739UP20968087
740DOWN53606217
741DOWN126803610
742UP5239329
743DOWN6926114
744UP479373144
745UP167210
746UP7706511
747DOWN4344209
748UP289657115
749UP2766615
750UP16522045
751UP1295515
752UP17331117
753UP172865176
754UP1958325
755UP109232225
756UP52222759
757DOWN892813010
758UP76811415
759DOWN3953216
760DOWN905071
761DOWN37937253
762DOWN1013381
763UP58458
764DOWN1249492
765UP41295878
766UP3727920
767DOWN573092
768UP234045198
769UP45321622
770UP119894277
771DOWN10387397
772DOWN12955157
773UP1044818914
774DOWN28956950
775UP34982125
776UP85571126
777UP636853105
778UP219553143
779UP71684203
780DOWN31924210
781UP21533284
782UP38581126
783UP90242224
784UP497538
785DOWN50310293
786UP4495683
787UP7892634
788DOWN118062816
789DOWN1262116
790UP41131730
791UP1638108330
792UP9851838
793DOWN4070218
794UP109177272
795UP156155135
796UP31641747
797UP31448557
798DOWN13972014
799UP25501174
800UP53221178
801DOWN4813366
802DOWN709910512
803UP10758632
804DOWN4950227
805UP9211911
806UP4718630
807DOWN2581112
808UP3382128
809UP285069161
810UP5703017
811UP1736102110
812DOWN9390103
813UP79521419
814DOWN3792103
815DOWN9887316
816DOWN27124
817DOWN345190
818UP3047234
819DOWN518614524
820UP346781
821UP1508738
822DOWN1129221113
823UP2430619
824UP25545563
825DOWN1086990
826UP95531625
827DOWN8832194
828DOWN5761222
829DOWN237871
830DOWN830481
831UP48231119
832DOWN422981
833UP272227
834UP1332548
835UP1114122
836UP645917
837UP2953311
838UP8073173
839UP204019
840UP133658290
841UP6796615
842UP1455722
843UP257629145
844UP129319117
845DOWN3518181
846DOWN3819109
847UP47342238
848UP1026509
849UP10344423
850DOWN124911811
851UP11621218
852UP8384720
|
Example 4
Pfam Annotation of Polypeptides of the Invention
Using the Pfam software program (Sonnhammer et al., Nucleic Acids Res., Vol. 26(1) pp. 320-322 (1998) herein incorporated by reference), the polypeptides of the invention (SEQ ID NO: 853 through 1704) we determined. Further description of the Pfam models can be found at http://pfam.wustl.edu/.
The following table lists the polypeptides of SEQ ID NO 853 through 1704 that had significant Pfam model hits:
TABLE 3
|
|
SEQ ID
NO:ModelRepeatsPositionScoreE_valueDescription
|
|
853TPR1/1297-33014.00.036TPR Domain
854Sterol_desat1/1 24-214268.22.9e−81Sterol
desaturase
856ras1/1 8-194335.51.4e−98Ras family
857thyroglobulin_11/1 7-86140.82.5e−38Thyroglobulin
type-1 repeat
860thiored2/2 65-173131.13.3e−38Thioredoxin
861GP1201/121-445.60.81Envelope
glycoprotein
GP120
861TIMP1/1 69-246484.31.9e−176Tissue
inhibitor of
metalloproteinase
863globin1/1 20-160203.04.6e−57Globin
864COX11/1 5-461867.83.4e−257Cytochrome C
and Quinol
oxidase
polypeptide
866PGAM1/1 13-241436.52.3e−127Phosphoglycerate
mutase family
8692OG-FeII_Oxy1/1117-14615.50.0052OG-Fe(II)
oxygenase
superfamily
870LIM1/1281-33778.58.5e−21LIM domain
870PDZ1/1 30-10986.73e−23PDZ domain
(Also known as
DHR or GLGF)
873GDPD1/1243-32473.64.1e−21Glycerophosphoryl
diester
phosphodiest
874rrm1/3204-27448.11.1e−12RNA recognition
motif. (a.k.a.
RRM, RBD,
874rrm2/3301-372112.31.3e−31RNA recognition
motif. (a.k.a.
RRM, RBD,
874rrm3/3496-55220.90.00011RNA recognition
motif. (a.k.a.
RRM, RBD,
875DUF2321/1396-4339.70.36Putative
transcriptional
regulator
875bZIP1/2233-2749.90.27bZIP
transcription
factor
875bZIP2/2408-4309.20.44bZIP
transcription
factor
875filament1/1181-496550.98.8e−162Intermediate
filament
protein
878Zip1/1209-354168.79.9e−47ZIP Zinc
transporter
879OATP_C1/1 78-445669.41.9e−197Organic Anion
Transporter
Polypeptide
(OATP
879OATP_N1/1520-662180.82.2e−50Organic Anion
Transporter
Polypeptide
(OATP
879kazal1/1471-49814.80.051Kazal-type
serine protease
inhibitor
domain
880G-gamma1/113-6798.21.1e−30GGL domain
881JNK1/1 55-311495.01.1e−156Jun-like
transcription
factor
881PspA_IM301/1344-3829.10.32PspA/IM30
family
881bZIP1/1320-38477.51.6e−20bZIP
transcription
factor
882chloroa_b-bind1/169-9328.35.6e−07Chlorophyll A-B
binding protein
883chloroa_b-bind1/1 82-133103.61.1e−28Chlorophyll A-B
binding protein
884Glyco_transf_251/1 35-219252.27.1e−72Glycosyltransferase
family 25
(LPS bi
885chloroa_b-bind1/1 78-12084.73.1e−23Chlorophyll A-B
binding protein
888DEP1/1454-528120.92.4e−32Domain found in
Dishevelled,
Egl-10, and
888DIX1/1 33-114196.25.1e−55DIX domain
888Dishevelled1/1174-245138.71.7e−46Dishevelled
specific domain
888PDZ1/1281-36887.81.5e−23PDZ domain
(Also known as
DHR or GLGF)
889DUF2321/2282-3168.50.72Putative
transcriptional
regulator
889K-box1/1176-1937.80.52K-box region
889filament1/1158-474527.78.2e−155Intermediate
filament
protein
890ank2/3 84-11611.90.14Ankyrin repeat
890ank3/3117-14920.60.00046Ankyrin repeat
891Herpes_HEPA1/185-993.40.86Herpesvirus DNA
helicase/primase
complex
891actin1/1 77-279440.89.4e−134Actin
892ig1/4 41-10036.71.6e−08Immunoglobulin
domain
892ig2/4175-23630.11.1e−06Immunoglobulin
domain
892ig3/4274-33319.20.0012Immunoglobulin
domain
893Ribosomal_L141/1 32-153218.59.7e−62Ribosomal
protein
L14p/L23e
894PMP22_Claudin1/1 73-223278.86.8e−80PMP-
22/EMP/MP20/Claudin
family
895alk_phosphatase1/1 41-5121065.80Alkaline
phosphatase
897CPSF_A1/1 821-1105508.35.8e−149CPSF A subunit
region
898Neur_chan_memb1/2 29-12493.31.2e−26Neurotransmitter-
gated ion-
channel tra
898Neur_chan_memb2/2220-24520.53.4e−05Neurotransmitter-
gated ion-
channel tra
899G-patch1/12311-235570.73.9e−19G-patch domain
899dsrm1/12378-241438.22.9e−09Double-stranded
RNA binding
motif
900serpin1/1 9-423515.31e−151Serpin (serine
protease
inhibitor)
901Lipoprotein_X 1/21224-24610.20.086Mycoplasma
MG185/MG260
protein
901Lipoprotein_X10/21477-50111.60.035Mycoplasma
MG185/MG260
protein
901Lipoprotein_X11/21502-52113.80.0086Mycoplasma
MG185/MG260
protein
901Lipoprotein_X12/21523-54112.80.017Mycoplasma
MG185/MG260
protein
901Lipoprotein_X13/21543-56618.60.00042Mycoplasma
MG185/MG260
protein
901Lipoprotein_X14/21567-59621.75.8e−05Mycoplasma
MG185/MG260
protein
901Lipoprotein_X15/21597-62113.70.0092Mycoplasma
MG185/MG260
protein
901Lipoprotein_X16/21622-64921.56.5e−05Mycoplasma
MG185/MG260
protein
901Lipoprotein_X17/21652-67112.50.021Mycoplasma
MG185/MG260
protein
901Lipoprotein_X18/21672-69615.60.0027Mycoplasma
MG185/MG260
protein
901Lipoprotein_X 2/21247-27111.90.03Mycoplasma
MG185/MG260
protein
901Lipoprotein_X20/21725-7548.50.25Mycoplasma
MG185/MG260
protein
901Lipoprotein_X 3/21273-29820.20.00015Mycoplasma
MG185/MG260
protein
901Lipoprotein_X 4/21303-32917.80.0007Mycoplasma
MG185/MG260
protein
901Lipoprotein_X 5/21332-35616.50.0016Mycoplasma
MG185/MG260
protein
901Lipoprotein_X6/21357-38619.50.00023Mycoplasma
MG185/MG260
protein
901Lipoprotein_X 7/21387-41923.12.3e−05Mycoplasma
MG185/MG260
protein
901Lipoprotein_X 8/21422-44617.80.0007Mycoplasma
MG185/MG260
protein
901Lipoprotein_X 9/21447-47618.80.00035Mycoplasma
MG185/MG260
protein
902Seryl_tRNA_N1/127-7876.94.2e−19Seryl-tRNA
synthetase N-
terminal domain
902tRNA-synt_2b1/1224-391201.29e−59tRNA synthetase
class II core
domain (G,
903CH1/1 81-19641.35.2e−10Calponin
homology (CH)
domain
903IQ1/3730-75023.40.00011IQ calmodulin-
binding motif
903IQ2/3760-78022.60.00018IQ calmodulin-
binding motif
903IQ3/3790-81013.70.063IQ calmodulin-
binding motif
903Peptidase_C571/11233-12405.80.74Vaccinia virus
I7 processing
peptidase
903RasGAP1/1 977-1190341.78.1e−99GTPase-
activator
protein for
Ras-like G
903RasGAP_C1/11405-1540227.61.8e−64RasGAP C-
terminus
903WW1/1650-66413.90.041WW domain
904Alpha_L_fucos1/1 20-4141057.30Alpha-L-
fucosidase
906hormone1/1 19-10661.22.3e−22Somatotropin
hormone family
907rrm1/1307-37884.12.8e−23RNA recognition
motif. (a.k.a.
RRM, RBD, or
911cyclin1/1 75-202169.36.5e−47Cyclin, N-
terminal domain
911cyclin_C1/1204-33278.76.1e−20Cyclin, C-
terminal domain
912RIIa1/154-9163.43.5e−16Regulatory
subunit of type
II PKA R-subu
912cNMP_binding1/2181-269106.87.1e−29Cyclic
nucleotide-
binding domain
912cNMP_binding2/2299-393117.75.9e−32Cyclic
nucleotide-
binding domain
913DSBA1/161-7612.50.023DSBA
oxidoreductase
913RNA_pol_L1/1 35-127200.34.6e−60RNA polymerases
L/13 to 16 kDa
subunit
914Collagen 1/21602-65037.11.1e−08Collagen triple
helix repeat
(20 copies)
914Collagen10/21941-97119.60.00068Collagen triple
helix repeat
(20 copies)
914Collagen11/21 984-101214.70.015Collagen triple
helix repeat
(20 copies)
914Collagen17/211249-12698.01Collagen triple
helix repeat
(20 copies)
914Collagen21/211473-151734.07.4e−0820/21 1434
1446 . . . 113
914Collagen 3/21676-73549.93.2e−12Collagen triple
helix repeat
(20 copies)
914Collagen 4/21736-78039.13e−09Collagen triple
helix repeat
(20 copies)
914Collagen 5/21781-84051.41.2e−12Collagen triple
helix repeat
(20 copies)
914Collagen 6/21854-88517.10.0033Collagen triple
helix repeat
(20 copies)
914Seryl_tRNA_N1/1520-53712.50.13Seryl-tRNA
synthetase N-
terminal domain
915GNT-I1/1 45-4771084.90GNT-I family
916CBM_142/6922-9429.20.14Chitin binding
Peritrophin-A
domain
916CBM_144/61763-178310.70.0473/6 1643
1665 . . . 3558
916CBM_145/61923-194311.40.0283/6 1643
1665 . . . 3558
916EGF10/47748-78331.43.7e−07EGF-like domain
916EGF11/47858-89441.84.1e−10EGF-like domain
916EGF12/47900-93637.75.9e−09EGF-like domain
916EGF13/47942-97627.16e−06EGF-like domain
916EGF14/471045-108137.09.4e−09EGF-like domain
916EGF15/471163-119931.63.1e−07EGF-like domain
916EGF16/471205-124217.70.0026EGF-like domain
916EGF17/471248-128428.13.1e−06EGF-like domain
916EGF18/471290-132627.16e−06EGF-like domain
916EGF19/471332-136722.50.00012EGF-like domain
916EGF 2/47250-27618.00.0021EGF-like domain
916EGF20/471373-140931.92.5e−07EGF-like domain
916EGF21/471415-144629.21.5e−06EGF-like domain
916EGF22/471457-149226.58.7e−06EGF-like domain
916EGF23/471498-153327.54.6e−06EGF-like domain
916EGF24/471539-157533.41e−07EGF-like domain
916EGF25/471581-161625.91.3e−05EGF-like domain
916EGF26/471622-165725.61.6e−05EGF-like domain
916EGF27/471741-177736.31.5e−08EGF-like domain
916EGF28/471783-181815.90.0086EGF-like domain
916EGF29/471901-193730.46.8e−07EGF-like domain
916EGF 3/47281-30816.90.0045EGF-like domain
916EGF30/471943-197629.51.3e−06EGF-like domain
916EGF31/471984-202021.00.00031EGF-like domain
916EGF32/472026-205917.60.0029EGF-like domain
916EGF33/472065-210237.85.5e−09EGF-like domain
916EGF34/472108-214225.12.2e−05EGF-like domain
916EGF35/472148-218432.81.4e−07EGF-like domain
916EGF36/472262-229522.99e−05EGF-like domain
916EGF37/472301-233523.85.1e−05EGF-like domain
916EGF38/472341-237626.01.2e−05EGF-like domain
916EGF39/472382-242020.00.00061EGF-like domain
916EGF 4/47381-41720.20.00051EGF-like domain
916EGF40/472426-246225.71.5e−05EGF-like domain
916EGF41/472537-257330.46.9e−07EGF-like domain
916EGF42/472579-261433.59e−08EGF-like domain
916EGF43/472620-265018.00.0022EGF-like domain
916EGF44/472659-269632.41.9e−07EGF-like domain
916EGF45/472702-273616.60.0054EGF-like domain
916EGF46/472742-277720.60.00041EGF-like domain
916EGF47/472783-281713.80.034EGF-like domain
916EGF 5/47423-45930.18.6e−07EGF-like domain
916EGF 6/47584-61424.53.2e−05EGF-like domain
916EGF 7/47625-65923.36.8e−05EGF-like domain
916EGF 8/47665-70138.34e−09EGF-like domain
916EGF 9/47707-74242.03.7e−10EGF-like domain
916TB 1/10324-36672.52.4e−21TB domain
916TB10/102477-252076.01.9e−22TB domain
916TB 2/10474-51969.62e−20TB domain
916TB 3/10799-84175.92e−22TB domain
916TB 4/10991-103259.33.6e−17TB domain
916TB 6/101096-113871.26.2e−21TB domain
916TB 7/101678-171979.21.8e−23TB domain
916TB 8/101835-187879.51.5e−23TB domain
916TB 9/102199-224173.01.7e−21TB domain
916wnt1/1434-4453.40.78wnt family
917Fragilysin1/1448-4956.80.39Fragilysin
metallopeptidase
(M10C) en
917Peptidase_M101/1160-266276.24.1e−79Matrixin
917Peptidase_M10_N1/1 80-154141.41.3e−48Matrix
metalloprotease,
N-terminal do
917UPF01431/1540-5606.20.89Uncharacterised
protein family
(UPF01
917fn21/3281-32292.43.9e−34Fibronectin
type II domain
917fn22/3339-38091.96.1e−34Fibronectin
type II domain
917fn23/3397-438104.01.4e−38Fibronectin
type II domain
917hemopexin1/4523-56642.42.7e−11Hemopexin
917hemopexin2/4568-61154.26.8e−15Hemopexin
917hemopexin3/4616-66373.01.3e−20Hemopexin
917hemopexin4/4665-70831.94.4e−08Hemopexin
918CD361/1 28-468797.93.8e−236CD36 family
920TSC221/1141-200146.44.8e−46TSC-22/dip/bun
family
921AMOP1/1483-646319.07e−96AMOP domain
921tsp_11/1417-45725.24.8e−06Thrombospondin
type 1 domain
923Peptidase_C11/1 85-334393.43.7e−117Papain family
cysteine
protease
926secY1/3 87-10811.60.013eubacterial
secY protein
926secY3/3278-47228.21.7e−07eubacterial
secY protein
927DUF1731/1583-62916.40.0014Uncharacterized
ACR, COG1354
928arf1/1 24-202423.32.1e−123ADP-
ribosylation
factor family
930EF1BD1/1175-261198.71.5e−56EF-1 guanine
nucleotide
exchange domain
931Myc-LZ1/1360-3908.50.75Myc leucine
zipper domain
931bZIP1/1327-39121.50.00014bZIP
transcription
factor
933CAP1/1 13-4831121.90CAP protein
9347tm_11/1179-431255.54.1e−827 transmembrane
receptor
(rhodopsin
family)
935NadA1/118-387.90.78Quinolinate
synthetase A
protein
935RrnaAD1/1133-1695.20.78Ribosomal RNA
adenine
dimethylase
935efhand1/434-6239.64.8e−09EF hand
935efhand2/470-9838.41e−08EF hand
935efhand3/4107-13542.19.8e−10EF hand
935efhand4/4143-17141.21.7e−09EF hand
936rrm1/2107-17659.45e−16RNA recognition
motif. (a.k.a.
RRM, RBD, or
936rrm2/2194-23743.03.4e−11RNA recognition
motif. (a.k.a.
RRM, RBD, or
939Vps551/1 26-15454.22.2e−14Vacuolar
protein sorting
55
940SH21/1110-19153.82.3e−17SH2 domain
943CH1/1 57-16979.51.4e−20Calponin
homology (CH)
domain
943calponin1/1206-23151.52e−14Calponin family
repeat
946PSI_PsaJ1/1185-2207.80.76Photosystem I
reaction centre
subunit IX/P
947YT521-B1/1436-526210.72.2e−59YT521-B-like
family
950HSP201/1 80-17673.54.9e−19Hsp20/alpha
crystallin
family
951CH1/2 55-15899.54.2e−26Calponin
homology (CH)
domain
951CH2/2168-273127.82e−34Calponin
homology (CH)
domain
951efhand1/2777-80522.50.00025EF hand
951efhand2/2818-84620.10.0012EF hand
951spectrin1/4299-40962.57.6e−16Spectrin repeat
951spectrin2/4419-524108.61.2e−28Spectrin repeat
951spectrin3/4535-64656.34.1e−14Spectrin repeat
951spectrin4/4657-76056.34.2e−14Spectrin repeat
952abhydrolase1/1172-40750.22.1e−14alpha/beta
hydrolase fold
953NIF1/1164-338358.81.4e−104NLI interacting
factor
954PMP22_Claudin1/1 12-127149.35.1e−42PMP-
22/EMP/MP20/Claudin
family
955Exo_endo_phos1/1400-699140.82.4e−38Endonuclease/Ex
onuclease/phosphatase
fa
956rrm1/1 49-11578.61.1e−21RNA recognition
motif. (a.k.a.
RRM, RBD, or
956zf-CCHC1/1140-15720.40.00095Zinc knuckle
958SH31/1365-41352.49.2e−13SH3 domain
959ELH1/1247-2734.40.71Egg-laying
hormone
precursor
959TGF-beta1/1337-445218.21.3e−62Transforming
growth factor
beta like
959TGFb_propeptide1/1 61-293194.02.3e−54TGF-beta
propeptide
959Tub1/1255-2642.30.33Tub family
960Hydrolase2/3347-37913.20.026haloacid
dehalogenase-
like hydrolase
961PABP1/1544-615166.73.8e−46Poly-adenylate
binding
protein, unique
961rrm1/414-8598.41.7e−27RNA recognition
motif. (a.k.a.
RRM, RBD
961rrm2/4102-17190.82.8e−25RNA recognition
motif. (a.k.a.
RRM, RBD
961rrm3/4194-264110.93.6e−31RNA recognition
motif. (a.k.a.
RRM, RBD
961rrm4/4297-36686.55.3e−24RNA recognition
motif. (a.k.a.
RRM, RBD
962bZIP1/1672-73517.20.0023bZIP
transcription
factor
964COLFI1/1 948-1165561.65.7e−219Fibrillar
collagen C-
terminal domain
964Collagen 1/13105-14220.60.00035Collagen triple
helix repeat
(20 copies
964Collagen10/13657-71644.59.7e−11Collagen triple
helix repeat
(20 copies
964Collagen11/13717-77656.84e−14Collagen triple
helix repeat
(20 copies
964Collagen12/13780-83956.35.6e−14Collagen triple
helix repeat
(20 copies
964Collagen13/13840-89658.71.2e−14Collagen triple
helix repeat
(20 copies
964Collagen 2/13171-23064.53e−16Collagen triple
helix repeat
(20 copies
964Collagen 3/13237-29676.51.6e−19Collagen triple
helix repeat
(20 copies
964Collagen 4/13297-35666.39.5e−17Collagen triple
helix repeat
(20 copies
964Collagen 5/13357-41665.21.9e−16Collagen triple
helix repeat
(20 copies
964Collagen 6/13417-47665.61.5e−16Collagen triple
helix repeat
(20 copies
964Collagen 7/13477-53661.91.6e−15Collagen triple
helix repeat
(20 copies
964Collagen 8/13537-59667.35.2e−17Collagen triple
helix repeat
(20 copies
964Collagen 9/13597-65647.11.8e−11Collagen triple
helix repeat
(20 copies
964DNA_po13_beta1/1925-9479.30.39DNA polymerase
III beta
subunit, N-term
965DEAD1/1205-430273.34.3e−83DEAD/DEAH box
helicase
965helicase_C1/1477-548130.31.4e−35Helicase
conserved c-
terminal domain
966zf-RanBP1/1 85-11432.72.8e−07Zn-finger in
Ran binding
protein and
others
967DUF3431/1 12-131158.73.2e−44Protein of
unknown
function
(DUF343)
969UPF00051/1281-34719.40.00018Uncharacterized
protein family
UPF0005
970GSHPx1/1 45-159245.67e−70Glutathione
peroxidase
970RTX1/148-575.20.22RTX N-terminal
domain
971Insulin1/1122-17984.71.8e−21Insulin/IGF/Rel
axin family
9722OG-FeII_Oxy1/1353-45152.81.7e−132OG-Fe(II)
oxygenase
superfamily
975ank2/761-9333.78.2e−08Ankyrin repeat
975ank3/7 94-12622.10.00017Ankyrin repeat
975ank4/7127-15929.41.4e−06Ankyrin repeat
975ank5/7160-19244.28.8e−11Ankyrin repeat
975ank6/7193-22538.04.9e−09Ankyrin repeat
979Glyco_transf_291/1 86-373419.04.3e−122Glycosyltransferase
family 29
(sialyl
980TIM1/1 82-254383.93.8e−124Triosephosphate
isomerase
981adh_short1/1 60-308297.71.4e−85short chain
dehydrogenase
982Ribosomal_L24e1/1 40-110177.52.5e−51Ribosomal
protein L24e
985annexin1/4 63-130116.84.1e−31Annexin
985annexin2/4135-202109.09e−29Annexin
985annexin3/4219-28788.81.1e−22Annexin
985annexin4/4295-362106.84.2e−28Annexin
989Fz1/1147-266213.26.3e−72Fz domain
989NTR1/1298-40280.91.2e−20NTR/C345C
module
990WW1/1151-18048.01e−11WW domain
991Glyco_hydro_351/1 6-6689.44.7e−26Glycosyl
hydrolases
family 35
993PKI1/115-8498.01.2e−27cAMP-dependent
protein kinase
inhibitor
994RWP-RK1/163-748.40.71RWP-RK domain
994Stathmin1/1 26-165311.69.2e−90Stathmin family
999Peptidase_M11/1235-619659.86.6e−228Peptidase
family M1
1000Peptidase_C11/1256-483323.33.8e−96Papain family
cysteine
protease
1001IF-2B1/1 15-298436.23e−127Initiation
factor 2
subunit family
1002Cu_amine_oxid1/2315-722751.63.3e−222Copper amine
oxidase, enzyme
domain
1002Cu_amine_oxid2/2723-75961.91.3e−16Copper amine
oxidase, enzyme
domain
1002Cu_amine_oxidN21/1 58-145115.92.5e−32Copper amine
oxidase, N2
domain
1002Cu_amine_oxidN31/1161-26199.61.4e−28Copper amine
oxidase, N3
domain
1003DUF2791/1 98-1106.81Eukaryotic
protein of
unknown
function
1003TRAPP_Bet31/1 58-238418.56.1e−122Transport
protein
particle
(TRAPP) com
1004zf-CCCH1/2114-14049.62.8e−13Zinc finger C-
x8-C-x5-C-x3-H
type (and simil
1004zf-CCCH2/2152-17848.18e−13Zinc finger C-
x8-C-x5-C-x3-H
type (and simil
1007Peptidase_M131/1544-750262.34.3e−81Peptidase
family M13
1007Peptidase_M41/1582-59411.60.079Thermolysin
metallopeptidase,
catalytic
1008Cadherin_C_term1/1661-817280.32.5e−80Cadherin
cytoplasmic
region
1008cadherin1/5 92-18262.95.1e−17Cadherin domain
1008cadherin2/5196-289109.31.3e−30Cadherin domain
1008cadherin3/5303-404122.12.2e−34Cadherin domain
1008cadherin4/5417-51094.13.7e−26Cadherin domain
1008cadherin5/5523-61642.16.5e−11Cadherin domain
1010KH1/332-7857.35.9e−15KH domain
1010KH2/3116-16563.11.2e−16KH domain
1010KH3/3298-34658.33e−15KH domain
1011Glyco_hydro_2_N1/1 78-10119.80.00014Glycosyl
hydrolases
family 2, sugar b
1012C21/3158-24186.91.3e−23C2 domain
1012C23/3724-75721.59.4e−05C2 domain
1013PA28_alpha1/132-95155.41e−42Proteasome
activator pa28
alpha subunit
1013PA28_beta1/1126-275409.92.4e−119Proteasome
activator pa28
beta subunit
1013biopterin_H1/159-696.80.18Biopterin-
dependent
aromatic amino
acid h
1014ras1/1 27-12980.38.8e−23Ras family
1015Rhabdo_glycop1/1392-43910.60.019Rhabdovirus
spike
glycoprotein
1015ig1/3 90-17422.90.00011Immunoglobulin
domain
1015ig3/3308-36223.19.7e−05Immunoglobulin
domain
1016EGF1/5264-30015.10.014EGF-like domain
1016EGF2/5306-34335.32.9e−08EGF-like domain
1016EGF3/5349-38020.90.00033EGF-like domain
1016EGF4/5389-42519.10.0011EGF-like domain
1016EGF5/5431-46715.50.011EGF-like domain
1016TIL1/2297-3499.90.094Trypsin
Inhibitor like
cysteine rich
do
1016Tissue_fac1/1583-62520.10.00014Tissue_factor
1016Xlink1/133-647.80.008Extracellular
link domain
1016lectin_c1/1 47-10320.30.00082Lectin C-type
domain
1018FH21/1 1-5957.29.5e−15Formin Homology
2 Domain
1019GoLoco1/164-8433.61.4e−08LGN motif,
putative GEF
specific for G-
alpha
1019Rap_GAP1/1277-464424.31.1e−123Rap/ran-GAP
1020Cys_knot1/1297-394114.61.8e−30Cystine−knot
domain
1020IGFBP1/1 77-148115.51.4e−31Insulin-like
growth factor
binding protein
1020tsp_11/1249-29056.22.7e−15Thrombospondin
type 1 domain
1020vwc2/2151-214102.81.9e−28von Willebrand
factor type C
domain
1021rrm1/2 9-7277.81.9e−21RNA recognition
motif. (a.k.a.
RRM, RBD, or
1021rrm2/2208-27449.73.5e−13RNA recognition
motif. (a.k.a.
RRM, RBD, or
1022Ets1/1409-492206.73.5e−58Ets-domain
1023CRF1/1192-23070.09.6e−19Corticotropin-
releasing
factor family
1024Exonuclease1/1 64-236103.61.5e−27Exonuclease
1026OPR1/159-8850.19.8e−13Octicosapeptide
repeat
1027SSF1/2112-27928.81.7e−07Sodium: solute
symporter
family
1027SSF2/2400-51412.40.0086Sodium: solute
symporter
family
1029Ribosomal_S91/1 19-151294.93.2e−91Ribosomal
protein S9/S16
1031actin1/1 24-399942.32.3e−286Actin
1032gln-synt1/1249-502364.61.1e−105Glutamine
synthetase,
catalytic
domain
1032gln-synt_N1/1163-244128.61.6e−37Glutamine
synthetase,
beta-Grasp
domain
1034sushi1/3 71-11712.50.15Sushi domain
(SCR repeat)
1034sushi2/3137-19254.21.5e−12Sushi domain
(SCR repeat)
1034sushi3/3199-25254.99.6e−13Sushi domain
(SCR repeat)
1034trypsin1/1515-786155.71.2e−48Trypsin
1034vwa1/1304-502221.27.1e−64von Willebrand
factor type A
domain
1036efhand1/6 90-11819.00.0023EF hand
1036efhand2/6126-1549.60.91EF hand
1036efhand4/6210-23821.30.00053EF hand
1036efhand6/6287-3159.80.81EF hand
1037bZIP1/1 75-13578.11.1e−20bZIP
transcription
factor
1038AhpC-TSA1/1 16-165310.52e−89AhpC/TSA family
1039IBR1/1340-3897.30.81IBR domain
1039zf-C2H21/5319-34413.50.26Zinc finger,
C2H2 type
1039zf-C2H22/5350-37422.30.0018Zinc finger,
C2H2 type
1039zf-C2H23/5380-40226.10.00019Zinc finger,
C2H2 type
1039zf-C2H24/5408-43025.70.00024Zinc finger,
C2H2 type
1039zf-C2H25/5438-46123.50.00085Zinc finger,
C2H2 type
1040EGF2/2664-69113.20.052EGF-like domain
1040FAD_binding_71/1388-4126.01FAD binding
domain of DNA
photolyase
1040Pep_M12B_propep1/1 86-201164.77.6e−46Reprolysin
family
propeptide
1040Reprolysin1/1218-420400.81.3e−116Reprolysin
(M12B) family
zinc metallo
1040disintegrin1/1437-512102.08.2e−33Disintegrin
1041Na_H_antiporter1/1477-5238.80.26Na+/H+
antiporter
family
1041Na_sulph_symp1/2 19-174124.11.3e−34Sodium: sulfate
symporter
transmembran
1041Na_sulph_symp2/2225-585200.52.5e−56Sodium: sulfate
symporter
transmembran
1042MDM21/1177-18911.10.017p53-associated
protein (MDM2)
1042NAD_binding_11/1 65-16048.51.5e−12Oxidoreductase
NAD-binding
domain
1043trypsin1/1 95-331330.04e−104Trypsin
1045EGF 1/18 83-11027.06.3e−06EGF-like domain
1045EGF10/18803-83826.01.2e−05EGF-like domain
1045EGF11/18844-87921.20.00027EGF-like domain
1045EGF12/18885-92124.53.3e−05EGF-like domain
1045EGF13/18927-96324.72.9e−05EGF-like domain
1045EGF14/18 969-100622.10.00015EGF-like domain
1045EGF15/181107-114420.20.00053EGF-like domain
1045EGF16/181150-118530.46.7e−07EGF-like domain
1045EGF17/181304-133930.85.2e−07EGF-like domain
1045EGF18/181345-138431.53.5e−07EGF-like domain
1045EGF 2/18310-34530.66.1e−07EGF-like domain
1045EGF 4/18556-59229.81e−06EGF-like domain
1045EGF 5/18598-63428.13.2e−06EGF-like domain
1045EGF 6/18640-6619.20.68EGF-like domain
1045EGF 8/18721-75624.63e−05EGF-like domain
1045EGF 9/18762-79726.49.3e−06EGF-like domain
1045Fanconia1/1 9-315.60.94Fanconi anaemia
group A protein
1045TB1/4246-28954.51.1e−15TB domain
1045TB2/4367-40770.69.5e−21TB domain
1045TB3/41036-107974.27.2e−22TB domain
1045TB4/41213-125576.31.5e−22TB domain
1045VSP1/3660-6817.40.3
1045VSP3/3907-9276.90.41
1045granulin1/2621-6367.40.58Granulin
1048CSD1/8 53-11877.91.8e−20‘Cold-shock’
DNA-binding
domain
1048CSD3/8213-27689.01.3e−232/8 180
207 . . . 4471
1048CSD4/8337-3659.70.312/8 180
207 . . . 4471
1048CSD5/8376-42428.51.6e−062/8 180
207 . . . 4471
1048CSD6/8514-53811.30.112/8 180
207 . . . 4471
1048CSD7/8546-61076.54.6e−202/8 180
207 . . . 4471
1048CSD8/8701-76674.91.2e−192/8 180
207 . . . 4471
1050DIL1/1451-557160.92.2e−44DIL domain
1050FHA1/1 92-15850.01.5e−11FHA domain
1050PDZ1/1675-75886.34e−23PDZ domain
(Also known as
DHR or GLGF)
1051Lamp1/1 65-438832.21.7e−246Lysosome-
associated
membrane
glycoprot
1052pp-binding1/1103-17069.71.1e−17Phosphopantetheine
attachment
site
1053START1/1174-32458.64.1e−16START domain
1055HSP701/1620-6434.70.87Hsp70 protein
1055helicase_C1/1643-73250.38.6e−13Helicase
conserved C-
terminal domain
1056Calpain_III1/1385-542387.02.6e−113Calpain large
subunit, domain
III
1056Peptidase_C21/1 75-374739.11.9e−218Calpain family
cysteine
protease
1056Porin_21/1683-7065.90.69Porin subfamily
1056efhand2/4609-63714.70.036EF hand
1056efhand3/4639-66716.60.01EF hand
1057KOW1/1135-16934.81.3e−07KOW motif
1058TGF-beta1/1260-367121.42.7e−34Transforming
growth factor
beta like
domain
1062ig1/2 65-14213.70.039Immunoglobulin
domain
1062ig2/2172-23521.20.00032Immunoglobulin
domain
1063EGF2/2436-45112.10.1EGF-like domain
1063Glyco_hydro_561/1 38-376785.12.7e−232Hyaluronidase
1064DUF2321/2278-32914.60.017Putative
transcriptional
regulator
1064KE21/1315-3479.60.39KE2 family
protein
1064filament1/1 97-409568.15.6e−167Intermediate
filament
protein
1067PKD1/2280-31925.19.2e−07PKD domain
1067PKD2/2448-4767.00.5PKD domain
1068zf-B_box1/1228-26855.41.2e−12B-box zinc
finger
1069ras1/1 25-216372.21.9e−109Ras family
1070IRS1/1234-336206.53.9e−58PTB domain
(IRS-1 type)
1070PH1/1 71-18447.17.1e−12PH domain
1071Peptidase_M161/1 98-246240.82e−68Insulinase
(Peptidase
family M16)
1072CBM_201/1279-35631.54e−07Starch binding
domain
1073PRA11/1 80-240280.62e−80Prenylated rab
acceptor (PRA1)
1075CLN31/1 48-449889.88.1e−264CLN3 protein
1075FA_desaturase1/152-8311.70.019Fatty acid
desaturase
1076UPF01461/12989-30077.20.81Uncharacterised
protein family
(UPF0146
1076laminin_B2/21715-185183.27.3e−22Laminin B
(Domain IV)
1076laminin_EGF 1/22322-37830.14.1e−07Laminin EGF-
like (Domains
III and V)
1076laminin_EGF10/22798-84843.08.4e−11Laminin EGF-
like (Domains
III and V)
1076laminin_EGF11/22851-88329.08.8e−07Laminin EGF-
like (Domains
III and V)
1076laminin_EGF12/221460-150858.14e−15Laminin EGF-
like (Domains
III and V)
1076laminin_EGF14/221550-159644.62.9e−11Laminin EGF-
like (Domains
III and V)
1076laminin_EGF15/221599-164765.43.1e−17Laminin EGF-
like (Domains
III and V)
1076laminin_EGF16/221853-188315.10.0083Laminin EGF-
like (Domains
III and V)
1076laminin_EGF17/221886-193251.92.2e−13Laminin EGF-
like (Domains
III and V)
1076laminin_EGF18/221935-198851.43.2e−13Laminin EGF-
like (Domains
III and V)
1076laminin_EGF19/221991-204265.33.3e−17Laminin EGF-
like (Domains
III and V)
1076laminin_EGF 2/22381-44845.41.6e−11Laminin EGF-
like (Domains
III and V)
1076laminin_EGF20/222045-208945.41.7e−11Laminin EGF-
like (Domains
III and V)
1076laminin_EGF21/222092-213647.83.5e−12Laminin EGF-
like (Domains
III and V)
1076laminin_EGF22/222139-216716.00.0048Laminin EGF-
like (Domains
III and V)
1076laminin_EGF 3/22451-49334.13e−08Laminin EGF-
like (Domains
III and V)
1076laminin_EGF 4/22516-56047.15.7e−12Laminin EGF-
like (Domains
III and V)
1076laminin_EGF 5/22563-60640.44.5e−10Laminin EGF-
like (Domains
III and V)
1076laminin_EGF 6/22609-65151.43.3e−13Laminin EGF-
like (Domains
III and V)
1076laminin_EGF 7/22654-69640.64e−10Laminin EGF-
like (Domains
III and V)
1076laminin_EGF 8/22699-74745.02.2e−11Laminin EGF-
like (Domains
III and V)
1076laminin_EGF 9/22766-79538.71.4e−09Laminin EGF-
like (Domains
III and V)
1076laminin_G1/42898-29339.00.27Laminin G
domain
1076laminin_G3/43392-352445.21.3e−11Laminin G
domain
1076laminin_G4/43571-369860.65.7e−16Laminin G
domain
1076laminin_Nterm1/1 67-320285.93.8e−86Laminin N-
terminal
(Domain VI)
1077KOW1/112-4731.21.2e−06KOW motif
1077Ribosomal_L27e1/1 59-143213.67.4e−74Ribosomal L27e
protein family
1078arf1/1 64-240144.31e−39ADP-
ribosylation
factor family
1080UPF00051/1 99-279137.69.1e−39Uncharacterized
protein family
UPF0005
1081cyclin1/1 81-208163.24.4e−45Cyclin, N-
terminal domain
1081cyclin_C1/1210-33973.02.1e−18Cyclin, C-
terminal domain
1082Oxysterol_BP1/1442-858772.22.1e−228Oxysterol-
binding protein
1082PH1/1150-24287.52.9e−23PH domain
1083DUF3481/1110-12911.60.14Domain of
unknown
function
(DUF348)
1083rnaseH1/1600-73328.51e−06RNase H
1083rve1/1863-96327.59.7e−07Integrase core
domain
1083rvp1/163-8425.97.8e−06Retroviral
aspartyl
protease
1083rvt1/1185-35746.11.4e−11Reverse
transcriptase
(RNA-dependent
DNA pol
1084MAP1_LC31/1 40-143255.66.1e−75Microtubule
associated
protein 1A/1B,
light
10857tm_11/250-888.20.0457 transmembrane
receptor
(rhodopsin
family)
1089SlyX1/1273-2836.30.019SlyX
1090aa_permeases2/2359-41012.50.012
1092adh_short1/1 28-228149.04.1e−41short chain
dehydrogenase
1094Clusterin1/1 16-4631269.50Clusterin
1094Thymidylate_kin1/1338-3809.10.024Thymidylate
kinase
1096COLFI1/11248-1466568.89.2e−222Fibrillar
collagen C-
terminal domain
1096Collagen 1/18112-16127.35e−06Collagen triple
helix repeat
(20 copies)
1096Collagen10/18659-71860.63.6e−15Collagen triple
helix repeat
(20 copies)
1096Collagen11/18719-77870.28.4e−18Collagen triple
helix repeat
(20 copies)
1096Collagen12/18782-84168.42.7e−17Collagen triple
helix repeat
(20 copies)
1096Collagen13/18842-90160.44e−15Collagen triple
helix repeat
(20 copies)
1096Collagen14/18902-96159.28.9e−15Collagen triple
helix repeat
(20 copies)
1096Collagen15/18 962-102162.69.9e−16Collagen triple
helix repeat
(20 copies)
1096Collagen16/181023-108154.41.8e−13Collagen triple
helix repeat
(20 copies)
1096Collagen17/181082-114173.98.1e−19Collagen triple
helix repeat
(20 copies)
1096Collagen18/181142-119540.51.2e−09Collagen triple
helix repeat
(20 copies)
1096Collagen 2/18180-23850.42.3e−12Collagen triple
helix repeat
(20 copies)
1096Collagen 3/18239-29875.72.5e−19Collagen triple
helix repeat
(20 copies)
1096Collagen 4/18299-35864.92.4e−16Collagen triple
helix repeat
(20 copies)
1096Collagen 5/18359-41861.61.9e−15Collagen triple
helix repeat
(20 copies)
1096Collagen 6/18419-47861.12.6e−15Collagen triple
helix repeat
(20 copies)
1096Collagen 7/18479-53863.94.4e−16Collagen triple
helix repeat
(20 copies)
1096Collagen 8/18539-59864.62.9e−16Collagen triple
helix repeat
(20 copies)
1096Collagen 9/18599-65862.11.4e−15Collagen triple
helix repeat
(20 copies)
1098DUF4101/1 66-315513.51.6e−150Protein of
unknown
function
(DUF410)
1098v1101/1306-3268.70.55Viral family
110
1100G-alpha1/1 59-407820.08.4e−243G-protein alpha
subunit
1100arf1/1244-27925.64e−06ADP-
ribosylation
factor family
1101ECH1/1367-53973.01.4e−20Enoyl-coA
hydratase/isomerase
family
1101chromo1/177-11353.33.5e−14‘chromo’
(CHRromatin
Organization
MOdi
1102MAM1/1 27-184212.94.7e−60MAM domain
1102Y_phosphatase1/2 923-1153432.53.9e−126Protein-
tyrosine
phosphatase
1102Y_phosphatase2/21213-1447326.53.1e−94Protein-
tyrosine
phosphatase
1102bromodomain1/11008-10247.80.79Bromodomain
1102fn31/4281-36732.18e−08Fibronectin
type III domain
1102fn32/4379-4708.20.67Fibronectin
type III domain
1102fn33/4482-57542.58e−11Fibronectin
type III domain
1102ig1/1199-26223.19.9e−05Immunoglobulin
domain
1104PWWP1/1114-186123.04.9e−34PWWP domain
1105Bcl-21/1233-332165.62.1e−66Apoptosis
regulator
proteins, Bcl-2
family
1106sugar_tr1/1 15-468661.44.6e−195Sugar (and
other)
transporter
1107C21/1521-60052.41.1e−13C2 domain
1107Calpain_III1/1353-498269.11.9e−78Calpain large
subunit, domain
III
1107Peptidase_C21/1 29-347283.13.5e−81Calpain family
cysteine
protease
1108DSPc1/1317-457244.71.3e−69Dual
specificity
phosphatase,
catalytic
1108Rhodanese1/2130-16727.75.9e−07Rhodanese-like
domain
1108Y_phosphatase1/1387-4366.30.81Protein-
tyrosine
phosphatase
1109UPF01281/1467-4826.50.99Uncharacterised
protein family
(UPF0128)
1109WH21/11160-118014.60.023WH2 motif
1110rrm1/2420-47413.80.013RNA recognition
motif. (a.k.a.
RRM, RBD, or
1110rrm2/2504-57226.82e−06RNA recognition
motif. (a.k.a.
RRM, RBD, or
1112Fork_head1/1 55-19193.06.1e−24Fork head
domain
1113thyroglobulin_11/1156-228104.22.6e−27Thyroglobulin
type-1 repeat
1114E1_DerP2_DerF21/1 51-178185.68e−52ML domain
1115ENV_polyprotein1/1 2-2817.10.00015ENV polyprotein
(coat
polyprotein)
1116heme_11/1104-18453.86.5e−14Heme/Steroid
binding domain
1117IGFBP1/1 87-14599.45.7e−27Insulin-like
growth factor
binding pr
1117thyroglobulin_11/1234-309142.11e−38Thyroglobulin
type-1 repeat
1119EGF2/6181-21626.39.7e−06EGF-like domain
1119EGF3/6222-25623.65.9e−05EGF-like domain
1119EGF4/6262-29620.10.00056EGF-like domain
1119EGF5/6302-32912.50.078EGF-like domain
1119TIL1/4203-22210.70.051Trypsin
Inhibitor like
cysteine rich
domain
1119TIL2/4241-26215.70.0014Trypsin
Inhibitor like
cysteine rich
domain
1119VSP2/2282-30410.40.0451/2 242
266..129
1120ZU51/1 989-1093218.31.1e−61ZU5 domain
1120ank10/24340-37232.12.4e−07Ankyrin repeat
1120ank11/24373-40535.82.2e−08Ankyrin repeat
1120ank12/24406-43845.14.7e−11Ankyrin repeat
1120ank13/24439-47137.28.7e−09Ankyrin repeat
1120ank14/24472-50437.47.3e−09Ankyrin repeat
1120ank15/24505-53738.34.1e−09Ankyrin repeat
1120ank16/24538-57042.13.4e−10Ankyrin repeat
1120ank17/24571-60340.21.2e−09Ankyrin repeat
1120ank18/24604-63635.92e−08Ankyrin repeat
1120ank19/24637-66944.47.4e−11Ankyrin repeat
1120ank 2/24 80-11240.31.1e−09Ankyrin repeat
1120ank20/24670-70229.01.9e−06Ankyrin repeat
1120ank21/24703-73541.26.2e−10Ankyrin repeat
1120ank22/24736-76838.53.7e−09Ankyrin repeat
1120ank23/24769-80139.12.5e−09Ankyrin repeat
1120ank 3/24113-14542.62.4e−10Ankyrin repeat
1120ank 4/24146-17839.22.2e−09Ankyrin repeat
1120ank 5/24179-20220.60.00046Ankyrin repeat
1120ank 6/24212-24010.00.46Ankyrin repeat
1120ank 7/24241-27332.91.4e−07Ankyrin repeat
1120ank 8/24274-30644.76.2e−11Ankyrin repeat
1120ank 9/24307-33934.16.6e−08Ankyrin repeat
1120death1/14098-4181109.41e−30Death domain
1121LIM1/230-8777.02.2e−20LIM domain
1121LIM2/2 90-14740.06.9e−10LIM domain
1121PDZ1/1170-25670.01.8e−18PDZ domain
(Also known as
DHR or GLGF)
1121pkinase1/1349-626213.82.5e−60Protein kinase
domain
1122Yippee1/1 23-131263.82.2e−75Yippee putative
zinc-binding
protein
1123Kunitz_BPTI1/129-7994.21.6e−29Kunitz/Bovine
pancreatic
trypsin
inhibito
1125NHL1/1 73-10033.78e−08NHL repeat
1126PUF1/8861-89533.84.8e−08Pumilio-family
RNA binding
repeat
1126PUF2/8897-93132.31.4e−07Pumilio-family
RNA binding
repeat
1126PUF3/8933-96733.27.5e−08Pumilio-family
RNA binding
repeat
1126PUF4/8969-100340.36.7e−10Pumilio-family
RNA binding
repeat
1126PUF5/81005-103937.15.4e−09Pumilio-family
RNA binding
repeat
1126PUF6/81041-107545.22.6e−11Pumilio-family
RNA binding
repeat
1126PUF7/81077-111228.12.2e−06Pumilio-family
RNA binding
repeat
1126PUF8/81120-115431.03.3e−07Pumilio-family
RNA binding
repeat
1127Ribosomal_L7Ae1/1 30-11235.43.5e−09Ribosomal
protein
L7Ae/L30e/S12e/
Gadd4
1128S10_plectin1/1 21-118254.11.9e−72Plectin/S10
domain
1133CBM_142/21273-130211.40.028Chitin binding
Peritrophin-A
domain
1133Cys_knot2/22823-2919100.43.4e−26Cystine-knot
domain
1133EB2/3914-92711.80.19
1133TIL1/5401-45441.01.5e−11Trypsin
Inhibitor like
cysteine rich
do
1133TIL2/5758-81342.45.6e−12Trypsin
Inhibitor like
cysteine rich
do
1133TIL3/5882-93327.52.6e−07Trypsin
Inhibitor like
cysteine rich
do
1133TIL4/51252-130234.91.3e−09Trypsin
Inhibitor like
cysteine rich
do
1133vwa1/31383-1559173.29.1e−50von Willebrand
factor type A
domain
1133vwa2/31604-1770203.61e−58von Willebrand
factor type A
domain
1133vwa3/31797-1970184.63.9e−53von Willebrand
factor type A
domain
1133vwc 1/12456-49414.50.0079von Willebrand
factor type C
domain
1133vwc11/122688-275079.21.3e−21von Willebrand
factor type C
domain
1133vwc 3/12935-97425.84.1e−06von Willebrand
factor type C
domain
1133vwc 4/121305-13418.50.43von Willebrand
factor type C
domain
1133vwc 6/122363-243189.21.7e−24von Willebrand
factor type C
domain
1133vwc 9/122537-260090.66.4e−25von Willebrand
factor type C
domain
1133vwd1/4141-285133.15.4e−37von Willebrand
factor type D
domain
1133vwd2/4494-647183.42e−51von Willebrand
factor type D
domain
1133vwd3/4 973-1119153.11e−42von Willebrand
factor type D
domain
1133vwd4/42056-2208138.71.3e−38von Willebrand
factor type D
domain
1134thiored1/1 88-15144.06.3e−12Thioredoxin
1137pkinase1/1 78-352279.44.6e−80Protein kinase
domain
1138FGGY1/1 84-11111.30.051FGGY family of
carbohydrate
kinases, N-
termi
1138HSP701/1 85-6831382.00Hsp70 protein
1139Anti_proliferat1/1 61-221345.46.3e−100BTG1 family
1140EMP701/111-72125.39.5e−38Endomembrane
protein 70
1141Transglut_core1/1338-427185.87.1e−52Transglutaminase-
like
superfamily
1141Transglutamin_C1/2547-651107.02.6e−30Transglutaminase
family, C-
terminal i
1141Transglutamin_C2/2659-756108.87.2e−31Transglutaminase
family, C-
terminal i
1141Transglutamin_N1/1 74-195221.31.4e−64Transglutaminase
family
1143PCI1/1433-51357.33.8e−15PCI domain
1144PCI1/1781-864106.12.7e−29PCI domain
1145RTX1/1916-9523.31RTX N-terminal
domain
1145SMC_C1/11090-1291410.95.9e−121SMC family, C-
terminal domain
1145SMC_N1/1 93-271289.63.8e−83RecF/RecN/SMC N
terminal domain
1145SlyX1/1340-3513.60.4SlyX
1146PGM_PMM1/1512-622159.51.3e−44Phosphoglucomutase/
phosphomannomutase,
C-
1146PGM_PMM_I1/1 82-233186.93.3e−52Phosphoglucomutase/
phosphomannomutase,
al
1146PGM_PMM_II1/1264-374193.67e−62Phosphoglucomutase/
phosphomannomutase,
al
1146PGM_PMM_III1/1376-491174.21.7e−48Phosphoglucomutase/
phosphomannomutase,
al
1147C21/2101-16549.67.2e−13C2 domain
1148ig1/2 99-16929.02.3e−06Immunoglobulin
domain
1148ig2/2205-27340.21.8e−09Immunoglobulin
domain
1151efhand1/2254-28010.60.48EF hand
1151efhand2/2304-33210.60.48EF hand
1152SNase1/5137-23056.13.4e−14Staphylococcal
nuclease
homologue
1152SNase2/5303-39234.53e−08Staphylococcal
nuclease
homologue
1152SNase3/5405-56054.97e−14Staphylococcal
nuclease
homologue
1152SNase4/5589-72477.15.5e−20Staphylococcal
nuclease
homologue
1152SNase5/5914-95920.90.00017Staphylococcal
nuclease
homologue
1152TUDOR1/1741-861137.23e−37Tudor domain
1154filament1/1133-440581.64.8e−171Intermediate
filament
protein
1155Calsequestrin1/127-625.40.4Calsequestrin
1155EGF11/161557-156911.90.12EGF-like domain
1155EGF13/163876-390844.19.5e−11EGF-like domain
1155EGF14/163916-394931.33.7e−07EGF-like domain
1155EGF15/164136-416831.53.4e−07EGF-like domain
1155EGF16/164175-420324.92.5e−05EGF-like domain
1155EGF 3/16758-77010.90.22EGF-like domain
1155EGF 5/16870-8799.80.44EGF-like domain
1155SEA1/1106-220105.72.6e−30SEA domain
1155ig 1/22447-50835.83e−08Immunoglobulin
domain
1155ig10/222479-253344.31.3e−10Immunoglobulin
domain
1155ig11/222576-263039.33.1e−09Immunoglobulin
domain
1155ig12/222672-272641.86.5e−10Immunoglobulin
domain
1155ig13/222769-282343.03e−10Immunoglobulin
domain
1155ig14/222869-292340.81.2e−09Immunoglobulin
domain
1155ig15/222967-302144.41.2e−10Immunoglobulin
domain
1155ig16/223064-312126.21.3e−05Immunoglobulin
domain
1155ig17/223155-321527.08e−06Immunoglobulin
domain
1155ig18/223254-330831.64.4e−07Immunoglobulin
domain
1155ig19/223341-339537.41.1e−08Immunoglobulin
domain
1155ig 2/221719-177632.62.2e−07Immunoglobulin
domain
1155ig20/223442-349630.49.1e−07Immunoglobulin
domain
1155ig21/223531-358531.06.5e−07Immunoglobulin
domain
1155ig22/223617-367132.32.7e−07Immunoglobulin
domain
1155ig 3/221814-187033.91e−07Immunoglobulin
domain
1155ig 4/221908-196327.26.9e−06Immunoglobulin
domain
1155ig 5/221998-205545.08.5e−11Immunoglobulin
domain
1155ig 6/222093-214747.61.6e−11Immunoglobulin
domain
1155ig 7/222194-224845.08.5e−11Immunoglobulin
domain
1155ig 8/222287-234137.21.2e−08Immunoglobulin
domain
1155ig 9/222383-243742.54.2e−10Immunoglobulin
domain
1155laminin_B1/3623-75778.02.1e−20Laminin B
(Domain IV)
1155laminin_B2/31018-1152136.45.2e−37Laminin B
(Domain IV)
1155laminin_B3/31424-1556133.73.4e−36Laminin B
(Domain IV)
1155laminin_EGF10/151591-163861.54e−16Laminin EGF-
like (Domains
III and V)
1155laminin_EGF11/151641-169629.94.6e−07Laminin EGF-
like (Domains
III and V)
1155laminin_EGF12/153883-39109.40.37Laminin EGF-
like (Domains
III and V)
1155laminin_EGF15/154191-420510.40.19Laminin EGF-
like (Domains
III and V)
1155laminin_EGF 2/15792-83961.83.2e−16Laminin EGF-
like (Domains
III and V)
1155laminin_EGF 3/15842-89737.82.5e−09Laminin EGF-
like (Domains
III and V)
1155laminin_EGF 4/15919-94922.65.8e−05Laminin EGF-
like (Domains
III and V)
1155laminin_EGF 5/151153-118410.70.16Laminin EGF-
like (Domains
III and V)
1155laminin_EGF 6/151187-123467.39e−18Laminin EGF-
like (Domains
III and V)
1155laminin_EGF 7/151237-129132.96.5e−08Laminin EGF-
like (Domains
III and V)
1155laminin_EGF 8/151303-135055.42.3e−14Laminin EGF-
like (Domains
III and V)
1155laminin_EGF 9/151557-157614.60.012Laminin EGF-
like (Domains
III and V)
1155laminin_G1/33720-3859111.42e−30Laminin G
domain
1155laminin_G2/33985-4116128.92.2e−35Laminin G
domain
1155laminin_G3/34262-4395131.05.5e−36Laminin G
domain
1155ldl_recept_a1/4223-26247.28.4e−13Low-density
lipoprotein
receptor domain
1155ldl_recept_a2/4309-34754.84e−15Low-density
lipoprotein
receptor domain
1155ldl_recept_a3/4349-38757.18.3e−16Low-density
lipoprotein
receptor domain
1155ldl_recept_a4/4392-43144.08e−12Low-density
lipoprotein
receptor domain
1158PX1/1134-17320.10.00098PX domain
1158pkinase1/1210-467304.71.1e−87Protein kinase
domain
1158pkinase_C1/1468-54256.05.6e−16Protein kinase
C terminal
domain
1161DUF2601/156-823.30.95Protein of
unknown
function DUF260
1163K-box1/2 83-1106.91K-box region
1163Retrotrans_gag1/1193-28678.52.9e−21Retrotransposon
gag protein
1163zf-CCHC1/1367-38416.70.011Zinc knuckle
11647tm_21/1474-723376.56.9e−1127 transmembrane
receptor
(Secretin
family)
1164DsbB1/1475-5046.70.91Disulfide bond
formation
protein DsbB
1164EGF2/3 91-12012.50.077EGF-like domain
1164EGF3/3143-17516.20.0072EGF-like domain
1164GPS1/1421-47284.07.2e−22Latrophilin/CL-
1-like GPS
domain
1165sugar_tr1/1 39-492661.06.1e−195Sugar (and
other)
transporter
1167MBD1/114-6786.92.1e−22Methyl-CpG
binding domain
1168aa_permeases1/1356-4088.30.18Amino acid
permease
1170Reticulon1/1223-414368.12e−112Reticulon
1172FKBP1/1 41-135179.49.1e−54FKBP-type
peptidyl-prolyl
cis-trans
isomeras
1174abhydrolase1/2 47-10428.97e−08alpha/beta
hydrolase fold
1174abhydrolase2/2120-1867.60.24alpha/beta
hydrolase fold
1174abhydrolase_21/1173-1947.30.61Phospholipase/C
arboxylesterase
1176DUF3571/1449-4658.60.48Protein of
unknown
function
(DUF357)
1176Furin-like1/1627-6448.00.23Furin-like
cysteine rich
region
1176P1/1470-601250.42.5e−71Proprotein
convertase P-
domain
1176Peptidase_S81/1153-458436.32.8e−127Subtilase
family
1176VSP2/2667-6906.40.561/2 242
266..129
1179Exostosin1/1217-503327.61.4e−94Exostosin
family
1182COLFI1/11661-1872488.91.5e−190Fibrillar
collagen C-
terminal domain
1182Collagen10/201009-106853.82.6e−13Collagen triple
helix repeat
(20 copies)
1182Collagen11/201069-110426.49.2e−06Collagen triple
helix repeat
(20 copies)
1182Collagen12/201105-116142.53.5e−10Collagen triple
helix repeat
(20 copies)
1182Collagen13/201162-122154.61.6e−13Collagen triple
helix repeat
(20 copies)
1182Collagen14/201222-128154.22e−13Collagen triple
helix repeat
(20 copies)
1182Collagen15/201285-134442.92.6e−10Collagen triple
helix repeat
(20 copies)
1182Collagen16/201345-140455.59.3e−14Collagen triple
helix repeat
(20 copies)
1182Collagen17/201405-145734.26.5e−08Collagen triple
helix repeat
(20 copies)
1182Collagen18/201459-151857.23.1e−14Collagen triple
helix repeat
(20 copies)
1182Collagen19/201528-158759.09.7e−15Collagen triple
helix repeat
(20 copies)
1182Collagen2/20505-55341.46.8e−10Collagen triple
helix repeat
(20 copies)
1182Collagen20/201588-160711.10.14Collagen triple
helix repeat
(20 copies)
1182Collagen 3/20593-64834.16.9e−08Collagen triple
helix repeat
(20 copies)
1182Collagen 4/20649-70859.86e−15Collagen triple
helix repeat
(20 copies)
1182Collagen 5/20709-76858.81.1e−14Collagen triple
helix repeat
(20 copies)
1182Collagen 6/20769-82840.89.7e−10Collagen triple
helix repeat
(20 copies)
1182Collagen 7/20832-88734.55.5e−08Collagen triple
helix repeat
(20 copies)
1182Collagen 8/20889-94841.94.9e−10Collagen triple
helix repeat
(20 copies)
1182Collagen 9/20 949-100857.92e−14Collagen triple
helix repeat
(20 copies)
1182TSPN1/175-266290.01.7e−83Thrombospondin
N-terminal -
like domain
1182laminin_G1/1195-21814.60.0071Laminin G
domain
1185fibrinogen_C1/2235-335156.51e−43Fibrinogen beta
and gamma
chains, C-term
1185fibrinogen_C2/2377-45167.03.5e−18Fibrinogen beta
and gamma
chains, C-term
1187SH31/1335-38978.36.8e−20SH3 domain
1188AT_hook1/173-858.91AT hook motif
1188Vinculin1/1 43-8911728.40Vinculin family
1189annexin1/213-6767.11e−16Annexin
1189annexin2/2 75-142109.46.9e−29Annexin
1190Heme_oxygenase1/1 35-272639.91.4e−188Heme oxygenase
1192DED1/1 35-11219.80.00037Death effector
domain
1193proteasome1/1 38-226230.91.9e−65Proteasome A-
type and B-type
1194adh_short1/1 88-380244.71.3e−69short chain
dehydrogenase
1195V-ATPase_G1/1 13-118205.76.9e−58Vacuolar (H+)-
ATPase G
subunit
1197BTB2/2490-59481.64.7e−21BTB/POZ domain
1197ras2/2231-2506.20.92Ras family
1198AMP-binding1/1 1-245224.31.8e−63AMP-binding
enzyme
1199gla1/139-8067.32.6e−19Vitamin K-
dependent
carboxylation/gamma-
1200PDZ1/2119-19849.11.6e−12PDZ domain
(Also known as
DHR or GLGF)
1200PDZ2/2203-27725.21.1e−05PDZ domain
(Also known as
DHR or GLGF)
1201EPH_lbd1/1 20-200399.03.8e−117Ephrin receptor
ligand binding
domain
1201SAM1/1908-97293.93.6e−25SAM domain
(Sterile alpha
motif)
1201fn31/2327-41739.08.6e−10Fibronectin
type III domain
1201fn32/2437-52268.42.7e−18Fibronectin
type III domain
1201pkinase1/1618-874256.14.6e−73Protein kinase
domain
1202GTF2I1/6230-305172.66.9e−55GTF2I-like
repeat
1202GTF2I2/6438-513172.95.3e−55GTF2I-like
repeat
1202GTF2I3/6543-618182.06.2e−58GTF2I-like
repeat
1202GTF2I4/6648-723183.61.8e−58GTF2I-like
repeat
1202GTF2I5/6810-885177.32e−56GTF2I-like
repeat
1202GTF2I6/6 945-1020165.21.7e−52GTF2I-like
repeat
1202ribonuc_red_sm1/1869-8986.00.57Ribonucleotide
reductase,
small chain
1203GRAM1/113-9665.51.1e−17GRAM domain
1204FlpD1/1607-6225.51Methyl-
viologen-
reducing
hydrogenase,
1204crystall1/6971-99723.00.00046Beta/Gamma
crystallin
1204crystall2/61072-111949.76.5e−11Beta/Gamma
crystallin
1204crystall3/61133-112695.31.2e−24Beta/Gamma
crystallin
1204crystall4/61234-131762.78.2e−15Beta/Gamma
crystallin
1204crystall5/61330-140959.95.5e−14Beta/Gamma
crystallin
1204crystall6/61417-149784.03.1e−21Beta/Gamma
crystallin
1204gpdh1/1498-5085.10.055Glyceraldehyde
3-phosphate
dehydrogena
1205hormone1/1 2-143124.66.8e−46Somatotropin
hormone family
1206histone1/1 30-146188.41.1e−52Core histone
H2A/H2B/H3/H4
1208Gal-bind_lectin1/1 67-198277.22.1e−79Galactoside-
binding lectin
1209ENV_polyprotein1/11097-114063.82.4e−18ENV polyprotein
(coat
polyprotein)
1209rnaseH1/1662-76970.82.1e−18RNase H
1209rve1/1 885-1039126.33.5e−35Integrase core
domain
1209rvp1/1 20-11772.37.6e−19Retroviral
aspartyl
protease
1209rvt1/1203-380110.82.1e−29Reverse
transcriptase
(RNA-dependent
1211Peptidase_C11/1302-513353.92.6e−105Papain family
cysteine
protease
1211gpdh1/1430-4393.60.25Glyceraldehyde
3-phosphate
dehydrogenase
1212ANATO1/163-717.40.033Anaphylotoxin-
like domain
1214kazal1/118-5622.20.00062Kazal-type
serine protease
inhibitor
domain
1215p34-Arc1/116-7335.71e−08Arp2/3 complex,
34 kD subunit
p34-Arc
1216EGF2/3 64-10025.91.3e−05EGF-like domain
1216EGF3/3106-14013.20.05EGF-like domain
1217kazal1/139-8736.51.4e−07Kazal-type
serine protease
inhibitor
domain
1218filament1/113-76134.71.6e−36Intermediate
filament
protein
1219pkinase1/1 99-361290.71.8e−83Protein kinase
domain
1221transmembrane41/122-7052.31.5e−15Tetraspanin
family
1222ferritin1/1 1-109177.71.8e−49Ferritin-like
domain
1223DUF2601/133-684.80.23Protein of
unknown
function DUF260
1223bZIP1/116-5110.20.22bZIP
transcription
factor
1224hormone1/1 4-107119.84.2e−44Somatotropin
hormone family
1225sushi1/116-4327.41.7e−05Sushi domain
(SCR repeat)
1227L151/166-9244.53.2e−10Ribosomal
protein L15
1229Dynein_heavy1/1 11-12791.52.6e−26Dynein heavy
chain
1231dCMP_cyt_deam1/1 34-14098.51.3e−26Cytidine and
deoxycytidylate
deaminase
1232adh_short1/1 38-14699.83.4e−27short chain
dehydrogenase
1233ldh1/1 44-129143.73.2e−39lactate/malate
dehydrogenase,
NAD binding d
1234HMG_box1/2 1-6659.44.5e−15HMG (high
mobility group)
box
1234HMG_box2/2 82-14588.04.4e−23HMG (high
mobility group)
box
1236EGF1/3 2-2713.70.037EGF-like domain
1236EGF2/333-6830.18.6e−07EGF-like domain
1236EGF3/3 74-11028.13.1e−06EGF-like domain
1236PSI1/119-476.70.78Plexin repeat
1237cystatin1/1 2-93124.35.4e−35Cystatin domain
1239cadherin1/136-629.50.22Cadherin domain
1240bZIP1/1226-28216.80.003bZIP
transcription
factor
1242IF_tail1/1 1-85167.11.9e−46Intermediate
filament tail
domain
1244Ribosomal_S151/1 88-14914.60.0094Ribosomal
protein S15
1246ldh1/1 1-4282.04.4e−21lactate/malate
dehydrogenase,
NAD binding do
1246ldh_C1/1 44-130163.14.9e−45lactate/malate
dehydrogenase,
alpha/beta C-t
1249W21/135-9997.35.1e−29eIF4-
gamma/eIF5/eIF2-
epsilon
1251Pep_M12B_propep1/1120-19875.42.7e−20Reprolysin
family
propeptide
1251Reprolysin2/3352-44931.35.6e−07Reprolysin
(M12B) family
zinc metallo
1251Tfb21/1312-3303.30.1Transcription
factor Tfb2
1251tsp_12/4595-64543.12.3e−11Thrombospondin
type 1 domain
1251tsp_13/4888-94112.40.032Thrombospondin
type 1 domain
1251tsp_14/4947-99824.67.2e−06Thrombospondin
type 1 domain
1253ANATO1/160-664.40.46Anaphylotoxin-
like domain
1255UPF00051/1 15-14458.86.8e−16Uncharacterized
protein family
UPF0005
1256actin1/1 1-145358.01.5e−108Actin
1258OSCP1/1 37-209257.91.9e−75ATP synthase
delta (OSCP)
subunit
1259PA28_alpha1/1 9-72135.59.4e−37Proteasome
activator pa28
alpha subuni
1259PA28_beta1/190-239387.71.1e−112Proteasome
activator pa28
beta subunit
1260WD401/5166-20531.05.2e−07WD domain, G-
beta repeat
1260WD402/5216-25524.24.5e−05WD domain, G-
beta repeat
1260WD403/5262-30140.41.1e−09WD domain, G-
beta repeat
1260WD404/5306-34533.97.8e−08WD domain, G-
beta repeat
1260WD405/5363-40228.62.5e−06WD domain, G-
beta repeat
1261WD401/5 6-3813.20.059WD domain, G-
beta repeat
1261WD402/542-8041.84.4e−10WD domain, G-
beta repeat
1261WD404/5178-21628.62.5e−06WD domain, G-
beta repeat
1261WD405/5275-31324.14.6e-05WD domain, G-
beta repeat
1262Big_11/31337-13738.90.16Bacterial Ig-
like domain
(group 1)
1262CH1/2 72-17797.61.3e−25Calponin
homology (CH)
domain
1262CH2/2195-29778.23.2e−20Calponin
homology (CH)
domain
1262Filamin 1/24306-399127.42e−37Filamin/ABP280
repeat
1262Filamin10/241185-127496.07.1e−28Filamin/ABP280
repeat
1262Filamin11/241280-1374120.52.5e−35Filamin/ABP280
repeat
1262Filamin12/241380-1467139.63.8e−41Filamin/ABP280
repeat
1262Filamin13/241473-1563137.81.3e−40Filamin/ABP280
repeat
1262Filamin14/241569-1660124.81.2e−36Filamin/ABP280
repeat
1262Filamin15/241666-1756121.99.1e−36Filamin/ABP280
repeat
1262Filamin16/241812-186876.65.4e−22Filamin/ABP280
repeat
1262Filamin17/241873-1960145.46.6e−43Filamin/ABP280
repeat
1262Filamin18/241971-204663.26.8e−18Filamin/ABP280
repeat
1262Filamin19/242054-2141135.85.4e−40Filamin/ABP280
repeat
1262Filamin 2/24406-498122.75.3e−36Filamin/ABP280
repeat
1262Filamin20/242142-223778.21.8e−22Filamin/ABP280
repeat
1262Filamin21/242245-2332154.61e−45Filamin/ABP280
repeat
1262Filamin22/242339-242795.41.1e−27Filamin/ABP280
repeat
1262Filamin23/242436-2523103.73.2e−30Filamin/ABP280
repeat
1262Filamin24/242564-2653112.47.5e−33Filamin/ABP280
repeat
1262Filamin 3/24504-595129.16.1e−38Filamin/ABP280
repeat
1262Filamin 4/24601-688106.54.4e−31Filamin/ABP280
repeat
1262Filamin 5/24697-78894.32.4e−27Filamin/ABP280
repeat
1262Filamin 6/24794-891128.87.3e−38Filamin/ABP280
repeat
1262Filamin 7/24897-990127.91.4e−37Filamin/ABP280
repeat
1262Filamin 8/24 996-108686.55.7e−25Filamin/ABP280
repeat
1262Filamin 9/241092-1179163.52.1e−48Filamin/ABP280
repeat
1262Lipase_31/1977-9926.20.79Lipase (class
3)
1263CUE1/1296-33745.95.6e−12CUE domain
1264fibrinogen_C1/1 28-242252.84.6e−72Fibrinogen beta
and gamma
chains, C-term
1265HLH1/1 80-13274.31.7e−18Helix-loop-
helix DNA-
binding domain
1266transmembrane41/1 11-221270.72.9e−84Tetraspanin
family
1267HSP701/139-915.50.5Hsp70 protein
1267PC_rep1/8409-44218.50.0018Proteasome/cyclosome
repeat
1267PC_rep2/8443-47931.34e−07Proteasome/cyclosome
repeat
1267PC_rep3/8480-51430.56.9e−07Proteasome/cyclosome
repeat
1267PC_rep4/8517-55117.80.0029Proteasome/cyclosome
repeat
1267PC_rep5/8560-58911.40.19Proteasome/cyclosome
repeat
1267PC_rep7/8692-72317.50.0035Proteasome/cyclosome
repeat
1267PC_rep8/8724-75719.90.00071Proteasome/cyclosome
repeat
1268annexin1/418-85111.41.8e−29Annexin
1268annexin2/4 90-157105.79e−28Annexin
1268annexin3/4173-241108.01.8e−28Annexin
1268annexin4/4249-316122.38.8e−33Annexin
1269PID1/1 50-176162.38e−45Phosphotyrosine
interaction
domain
(PTB/PID)
1270globin1/1 3-147221.71.1e−62Globin
1273Connexin431/1301-32039.98.9e−10Gap junction
alpha-1 protein
(Cx43)
1273SMC_N1/1133-1446.50.73RecF/RecN/SMC N
terminal domain
1273connexin1/1 9-239576.91.2e−169Connexin
1274trypsin1/1 9-231318.02.6e−100Trypsin
1276MAGE1/1471-592119.52e−32MAGE family
1276SpoA1/1518-5358.30.88Surface
presentation of
antigens (SPOA)
1277SH31/1 68-12442.06.7e−10SH3 domain
1279ATP1G1_PLM_MAT81/120-75128.71.7e−38ATP1G1/PLM/MAT8
family
1280PAP21/1100-251179.55.5e−50PAP2
superfamily
1281cpn60_TCP11/1 39-529628.83.1e−185TCP-1/cpn60
chaperonin
family
1282thiored1/2 24-132167.53.5e−49Thioredoxin
1282thiored2/2159-270187.14.3e−55Thioredoxin
1283Astacin1/1561-5727.50.22Astacin
(Peptidase
family M12A)
1283notch1/3416-44113.50.09Notch (DSL)
domain
1283notch2/3451-47413.20.11Notch (DSL)
domain
1283sushi1/41215-128023.20.00022Sushi domain
(SCR repeat)
1283sushi2/41305-134215.80.02Sushi domain
(SCR repeat)
1283sushi3/41346-141032.57.9e−07Sushi domain
(SCR repeat)
1283sushi4/41415-147123.20.00022Sushi domain
(SCR repeat)
1284BAG1/1175-25584.61.4e−22BAG domain
1284ThiI1/1206-2237.20.53Thiamine
biosynthesis
protein (ThiI)
1284Tropomyosin1/1160-1838.40.2Tropomyosin
1284ubiquitin1/1 99-15127.63.3e−06Ubiquitin
family
1285bZIP1/1186-25035.31.6e−08bZIP
transcription
factor
1286HSP701/1 30-6351403.00Hsp70 protein
1286Hydantoinase_A1/1213-2367.60.13Hydantoinase/oxoprolinase
1287DSBA1/249-697.10.73DSBA
oxidoreductase
1287DSBA2/2357-4267.80.48DSBA
oxidoreductase
1287thiored1/2 24-133190.73.5e−56Thioredoxin
1287thiored2/2375-485183.55.2e−54Thioredoxin
1288TNF1/1153-28059.02.6e−15TNF(Tumor
Necrosis
Factor) family
1289Pyrophosphatase1/1 45-229440.31e−128Inorganic
pyrophosphatase
1290LIM1/3384-44256.51.5e−14LIM domain
1290LIM2/3444-50158.15.2e−15LIM domain
1290LIM3/3504-57037.34.2e−09LIM domain
1292isodh1/1 56-379301.72.7e−89Isocitrate/isopropylmalate
dehydrogenase
1293cofilin_ADF1/1 19-154195.21e−54Cofilin/tropomyosin-
type
actin-binding
pr
1294UQ_con1/1 2-154254.31.6e−72Ubiquitin-
conjugating
enzyme
1295ABC_tran1/1 7-2210.30.081ABC transporter
1295APS_kinase1/1 5-208.30.24Adenylylsulfate
kinase
1295DUF2581/1 8-258.40.19Protein of
unknown
function,
DUF258
1295Guanylate_kin1/1 40-144212.85.2e−60Guanylate
kinase
1295Rad171/1 9-286.30.48Rad17 cell
cycle
checkpoint
protein
1295SKI1/1 5-209.10.2Shikimate
kinase
1295Viral_helicasel1/1 7-275.50.95Viral
(Superfamily 1)
RNA helicase
1295cobW1/1 7-276.60.32Cobalamin
synthesis
protein/P47K
1297Gal-bind_lectin1/1117-247215.32.8e−61Galactoside-
binding lectin
1299Acetyltransf1/1157-17512.00.0055Acetyltransferase
(GNAT)
family
1299PapB1/1 98-1128.10.39Adhesin
biosynthesis
transcription
regu
1303CH1/2 44-14996.33.2e−25Calponin
homology (CH)
domain
1303CH2/2167-26982.42.2e−21Calponin
homology (CH)
domain
1303Filamin 1/24278-371159.14.6e−47Filamin/ABP280
repeat
1303Filamin10/241157-1246153.32.7e−45Filamin/ABP280
repeat
1303Filamin11/241252-1346146.04.4e−43Filamin/ABP280
repeat
1303Filamin12/241352-1439163.32.3e−48Filamin/ABP280
repeat
1303Filamin13/241445-1536167.41.3e−49Filamin/ABP280
repeat
1303Filamin14/241542-1633165.45.5e−49Filamin/ABP280
repeat
1303Filamin15/241639-1737130.12.9e−38Filamin/ABP280
repeat
1303Filamin16/241779-185797.62.3e−28Filamin/ABP280
repeat
1303Filamin17/241862-1949167.41.4e−49Filamin/ABP280
repeat
1303Filamin18/241951-2036101.71.3e−29Filamin/ABP280
repeat
1303Filamin19/242044-2131163.12.7e−48Filamin/ABP280
repeat
1303Filamin 2/24378-471155.36.3e−46Filamin/ABP280
repeat
1303Filamin20/242132-2227114.61.5e−33Filamin/ABP280
repeat
1303Filamin21/242235-2322161.01.2e−47Filamin/ABP280
repeat
1303Filamin22/242329-2417126.05.3e−37Filamin/ABP280
repeat
1303Filamin23/242426-2513135.56.7e−40Filamin/ABP280
repeat
1303Filamin24/242554-2643137.71.5e−40Filamin/ABP280
repeat
1303Filamin 3/24477-567148.67e−44Filamin/ABP280
repeat
1303Filamin 4/24573-660139.54.1e−41Filamin/ABP280
repeat
1303Filamin 5/24669-760165.55.3e−49Filamin/ABP280
repeat
1303Filamin 6/24766-863141.78.9e−42Filamin/ABP280
repeat
1303Filamin 7/24869-962154.51.1e−45Filamin/ABP280
repeat
1303Filamin 8/24 968-1058113.14.6e−33Filamin/ABP280
repeat
1303Filamin 9/241064-1151169.72.8e−50Filamin/ABP280
repeat
1304CMD1/1 90-1067.90.75Carboxymuconolactone
decarboxylase
1305Ribosomal_L7Ae1/1 21-12174.57.4e−21Ribosomal
protein
L7Ae/L30e/S12e/
Gadd4
1306Dynein_light1/1 1-89219.74.3e−62Dynein light
chain type 1
1308ig2/2119-18726.89.1e−06Immunoglobulin
domain
1309Glypican1/1 4-5781207.60Glypican
1310Astacin1/1128-321395.94.8e−122Astacin
(Peptidase
family M12A)
1310CUB1/5322-431204.46.2e−59CUB domain
1310CUB2/5435-544228.26.1e−66CUB domain
1310CUB3/5591-700210.59.9e−61CUB domain
1310CUB4/5747-856206.02.2e−59CUB domain
1310CUB5/5860-973173.67.4e−50CUB domain
1310EGF1/2551-58733.21.1e−07EGF-like domain
1310EGF2/2707-74227.25.5e−06EGF-like domain
1310VSP1/1572-5895.51Giardia
variant-
specific
surface protein
1311HIT1/114-125223.04.4e−63HIT family
1312proteasome1/1 56-238165.73.1e−46Proteasome A-
type and B-type
1313filament1/1 71-381335.65.5e−97Intermediate
filament
protein
1314Fasciclin1/4134-23861.91.2e−16Fasciclin
domain
1314Fasciclin2/4240-37399.81.3e−27Fasciclin
domain
1314Fasciclin3/4432-50010.50.078Fasciclin
domain
1314Fasciclin4/4502-634235.29.5e−67Fasciclin
domain
1315histone1/1 6-122165.01.3e−45Core histone
H2A/H2B/H3/H4
1317ATP-grasp1/1173-2529.90.085ATP-grasp
domain
1317Biotin_carb_C1/1372-480197.41.4e−56Biotin
carboxylase C-
terminal domain
1317CPSase_L_D21/1151-365437.01.7e−127Carbamoyl-
phosphate
synthase L
chain,
1317CPSase_L_chain1/1 37-149205.29.8e−58Carbamoyl-
phosphate
synthase L
chain,
1317HlyD1/1633-6607.10.94HlyD family
secretion
protein
1317SLT_beta1/1551-60510.10.1Shiga-like
toxin beta
subunit
1317biotin_lipoyl1/1635-702105.43e−28Biotin-
requiring
enzyme
1317gpD1/1169-1826.20.53Bacteriophage
scaffolding
protein D
1318Tropomyosin1/1 10-126235.38.9e−67Tropomyosin
1322Mtp1/1 36-233438.55.7e−128Golgi 4-
transmembrane
spanning
transporter
1323eIF5_eIF2B1/1182-310281.21.3e−80Domain found in
IF2B/IF5
1325BPL_C1/1151-1718.50.78Biotin protein
ligase C
terminal domain
1325Mov341/1 87-196149.75.1e−41Mov34/MPN/PAD-1
family
1326Ribosomal_L221/1 17-152236.63.5e−67Ribosomal
protein
L22p/L17e
1327MAPEG1/1 52-136156.75.8e−45MAPEG family
1328proteasome1/1 40-221165.82.8e−46Proteasome A-
type and B-type
1329C21/1435-51446.65.3e−12C2 domain
1329PH1/1314-41690.83.3e−24PH domain
1329RasGAP1/1608-782319.34.4e−92GTPase-
activator
protein for
Ras-like G
1329SH21/220-95112.01.4e−37SH2 domain
1329SH22/2190-265116.73.6e−39SH2 domain
1329SH31/1121-17845.09.8e−11SH3 domain
1330AAA1/1221-408303.81.2e−90ATPase family
associated with
various
1330IstB1/1222-2388.30.23IstB-like ATP
binding protein
1330Parvo_NS11/1222-2407.80.17Parvovirus non-
structural
protein NS1
1330RNA_helicase1/1222-24212.80.016RNA helicase
1331serpin1/1 51-415283.63.8e−83Serpin (serine
protease
inhibitor)
1332TGF-beta1/1208-30865.08.5e−18Transforming
growth factor
beta like domai
1334BRICHOS1/1137-231132.05.2e−37BRICHOS domain
1337DUF2321/1 14-149155.49.8e−43Putative
transcriptional
regulator
1339Ribosomal_L271/1 31-10171.75.3e−20Ribosomal L27
protein
1340TPR1/1313-33610.40.38TPR Domain
1342sushi1/436-9450.11.8e−11Sushi domain
(SCR repeat)
1342sushi2/4 98-15843.21.2e−09Sushi domain
(SCR repeat)
1342sushi3/4163-22056.24.4e−13Sushi domain
(SCR repeat)
1342sushi4/4225-28375.41.2e−18Sushi domain
(SCR repeat)
1345UCR_hinge1/127-91162.61.5e−46Ubiquinol-
cytochrome C
reductase hinge
prot
1349AAA1/1185-372305.15e−91ATPase family
associated with
various
1349IstB1/1180-20511.00.037IstB-like ATP
binding protein
1349Parvo_NS11/1186-20715.60.00085Parvovirus non-
structural
protein NS1
1349RNA_helicase1/1186-20411.90.028RNA helicase
1349Sigma54_activat1/1186-20310.40.049Sigma-54
interaction
domain
1351Robl_LC71/1 3-94113.63.8e−30Roadblock/LC7
domain
1352YT521-B1/1457-547212.47e−60YT521-B-like
family
1353AAA1/1211-398291.46.7e−87ATPase family
associated with
various ce
1353RNA_helicase1/1212-2328.50.25RNA helicase
1354WD401/6 3-4119.40.001WD domain, G-
beta repeat
1354WD402/647-8740.11.3e−09WD domain, G-
beta repeat
1354WD403/693-13331.53.6e−07WD domain, G-
beta repeat
1354WD404/6140-19542.62.5e−10WD domain, G-
beta repeat
1354WD405/6202-24438.83.2e−09WD domain, G-
beta repeat
1354WD406/6253-29014.70.023WD domain, G-
beta repeat
1355zf-C3HC41/1 76-11638.41.6e−10Zinc finger,
C3HC4 type
(RING finger)
1358UDPGP1/1 43-462892.99.5e−265UTP - glucose-1-
phosphate
uridylyltransferase
1360W21/1336-416120.23.6e−36eIF4-
gamma/eIF5/eIF2-
epsilon
1362Ribosomal_L34e1/1 5-103229.84e−65Ribosomal
protein L34e
1363Ribosomal_L18p1/126-99118.51.3e−31Ribosomal
L18p/L5e family
1365ATP-gua_Ptrans1/1148-414655.92.1e−193ATP: guanido
phosphotransferase,
C-ter
1365ATP-gua_PtransN1/1 52-135192.85.3e−54ATP: guanido
phosphotransferase,
N-ter
1366DUF2321/1 8-142189.07.6e−53Putative
transcriptional
regulator
1367Triabin1/1119-13612.10.017Triabin
1367lipocalin1/1 38-186149.13.9e−42Lipocalin/
cytosolic
fatty-acid
binding pr
1369CSD1/162-9838.81.9e−09‘Cold-shock’
DNA-binding
domain
137060s_ribosomal1/1 22-113129.06.3e−3760s Acidic
ribosomal
protein
1371thiored1/1 2-106155.71.2e−45Thioredoxin
1372LIM1/228-8562.33.3e−16LIM domain
1372LIM2/2137-19470.71.3e−18LIM domain
1373PX1/1137-265143.53.8e−39PX domain
1373Sorting_nexin1/1 2-134295.93.3e−91Sorting nexin,
N-terminal
domain
1374rrm1/118-8265.67.7e−18RNA recognition
motif. (a.k.a.
RRM, RBD, or
1375NHL2/2256-2549.80.6NHL repeat
1375Str_synth1/1 40-408325.72.8e−97Strictosidine
synthase
1377Cation_ATPase_C1/1 834-1012238.14.2e−71Cation
transporting
ATPase, C-
N-terminu
1377Cation_ATPase_N1/1 33-116134.26.9e−37Cation
transporter/ATPase,
N-terminus
1377E1-E2_ATPase1/1135-366391.65.1e−118E1-E2 ATPase
1377Hydrolase1/2370-63331.33.4e−07haloacid
dehalogenase -
like hydrolase
1377Hydrolase2/2687-73841.94.7e−10haloacid
dehalogenase-
like hydrolase
1379SCAMP1/1131-308359.05e−104SCAMP family
1380COX41/1 26-169242.17.7e−69Cytochrome c
oxidase subunit
IV
1381LIM1/1260-31545.61.8e−11LIM domain
1381PDZ1/1 3-8496.25.8e−26PDZ domain
(Also known as
DHR or GLGF)
1382CoaE1/121-389.00.11Dephospho-CoA
kinase
1382PRK1/1 22-229230.62.3e−65Phosphoribulokinase/
Uridine
kinase family
1383ras1/1 61-240329.87e−97Ras family
1384Leptin1/1 40-185392.41.4e−120Leptin
1385DUF3871/1 78-1005.80.99Putative
transcriptional
regulators (Yp
1385Ribosomal_S251/1 1-113262.36.5e−75S25 ribosomal
protein
1386DEAD1/1 51-254242.31.5e−73DEAD/DEAH box
helicase
1386helicase_C1/1301-372127.96.6e−35Helicase
conserved C-
terminal domain
1388ank2/5110-14232.61.8e−07Ankyrin repeat
1388ank3/5143-17516.50.0069Ankyrin repeat
1388ank4/5182-21439.51.9e−09Ankyrin repeat
1388ank5/5216-24841.07.1e−10Ankyrin repeat
1390PX1/1505-62695.69.9e−25PX domain
1390PXA1/1122-25342.52.7e−10PXA domain
1391SUI11/1 9-109225.96e−64Translation
initiation
factor SUI1
1392perilipin1/1 2-396813.36.8e−244Perilipin
family
1393PRA11/1 8-5515.30.0047Prenylated rab
acceptor (PRA1)
1395ENV_polyprotein1/1265-486159.21.6e−46ENV polyprotein
(coat
polyprotein)
1396LRR 1/10 82-10516.80.007Leucine Rich
Repeat
1396LRR 2/10106-12912.90.085Leucine Rich
Repeat
1396LRR 3/10130-14914.80.025Leucine Rich
Repeat
1396LRR 4/10151-1749.11Leucine Rich
Repeat
1396LRR 7/10222-24517.10.0055Leucine Rich
Repeat
1396LRR 8/10246-2699.80.65Leucine Rich
Repeat
1396LRR 9/10270-29215.30.018Leucine Rich
Repeat
1396LRRNT1/253-8043.32.8e−10Leucine rich
repeat N-
terminal domain
1397Ribosomal_S271/1101-147119.08.7e−32Ribosomal
protein S27a
1397ubiquitin1/1 1-74153.14.8e−42Ubiquitin
family
1398Kunitz_BPTI1/336-8693.62.6e−29Kunitz/Bovine
pancreatic
trypsin
inhibito
1398Kunitz_BPTI2/3 96-14938.72.1e−11Kunitz/Bovine
pancreatic
trypsin
inhibito
1398Kunitz_BPTI3/3158-20885.31.3e−26Kunitz/Bovine
pancreatic
trypsin
inhibito
1398kinesin1/1221-2315.80.8Kinesin motor
domain
1399proteasome1/1 28-216186.14.6e−52Proteasome A-
type and B-type
1401AAA1/1169-356316.02.7e−94ATPase family
associated with
various
1401IstB1/1170-1867.90.31IstB-like ATP
binding protein
1401Parvo_NS11/1171-1886.50.4Parvovirus non-
structural
protein NS1
1401RNA_helicase1/1170-19111.70.032RNA helicase
1401Sigma54_activat1/1171-1877.10.44Sigma-54
interaction
domain
1403TB1/146-718.60.35TB domain
1403kazal1/2121-16748.11.4e−10Kazal-type
serine protease
inhibitor
domain
1403kazal2/2195-24336.51.4e−07Kazal-type
serine protease
inhibitor
domain
140460s_ribosomal1/1 17-114114.81e−3260s Acidic
ribosomal
protein
1404Peptidase_M4_C1/112-326.50.31Thermolysin
metallopeptidase,
alpha-he
1406zf-C3HC41/1 79-10210.30.069Zinc finger,
C3HC4 type
(RING finger)
1408Adap_comp_sub1/158-957.60.054Adaptor
complexes
medium subunit
famil
1408Clat_adaptor_s1/1 1-142325.84.8e−94Clathrin
adaptor complex
small chain
1409Calsequestrin2/2235-34820.21.6e−05Calsequestrin
1409DSBA1/3 83-10410.20.1DSBA
oxidoreductase
1409DSBA2/3194-2257.40.62DSBA
oxidoreductase
1409DSBA3/3547-57616.20.0021DSBA
oxidoreductase
1409thiored1/3 61-169184.72.2e−54Thioredoxin
1409thiored2/3176-284193.45.2e−57Thioredoxin
1409thiored3/3524-636182.51e−53Thioredoxin
1410APS_kinase1/121-3910.80.042Adenylylsulfate
kinase
1410CoaE1/1 20-198321.35e−96Dephospho-CoA
kinase
1410PRK1/121-3918.50.00032Phosphoribulokinase/
Uridine
kinase
1410UPF00421/119-487.40.33Uncharacterised
P-loop ATPase
protein
1411Fz1/1 1-2122.87.9e−07Fz domain
1411Zn_carbOpept1/2 50-16069.86.6e−18Zinc
carboxypeptidase
1411Zn_carbOpept2/2172-43190.91.3e−23Zinc
carboxypeptidase
1412ANATO1/336-6941.25.9e−15Anaphylotoxin-
like domain
1412ANATO2/3 77-11029.61.4e−10Anaphylotoxin-
like domain
1412ANATO3/3112-14437.02.3e−13Anaphylotoxin-
like domain
1412EGF1/8180-21416.30.0067EGF-like domain
1412EGF3/8312-35419.90.00063EGF-like domain
1412EGF4/8360-39740.68.8e−10EGF-like domain
1412EGF5/8403-43925.91.3e−05EGF-like domain
1412EGF6/8445-47913.20.05EGF-like domain
1412EGF7/8485-52329.31.4e−06EGF-like domain
1413rrm1/3192-23332.93.1e−08RNA recognition
motif. (a.k.a.
RRM, RBD, or
1413rrm2/3260-32766.44.4e−18RNA recognition
motif. (a.k.a.
RRM, RBD, or
1413rrm3/3346-41475.01.3e−20RNA recognition
motif. (a.k.a.
RRM, RBD, or
1414Ribosomal_S111/1 29-147234.93.4e−72Ribosomal
protein S11
1415Ribosomal_L29e1/125-6483.64.4e−23Ribosomal L29e
protein family
1416Ribosomal_L11/1 5-213348.76.4e−127Ribosomal
protein
L1p/L10e family
1418LRR 1/1067-9015.20.019Leucine Rich
Repeat
1418LRR10/10305-33013.90.044Leucine Rich
Repeat
1418LRR 2/10 91-11611.00.3Leucine Rich
Repeat
1418LRR 4/10138-15916.10.011Leucine Rich
Repeat
1418LRR 5/10160-18412.90.088Leucine Rich
Repeat
1418LRR 6/10185-20416.60.0078Leucine Rich
Repeat
1418LRR 7/10206-22917.10.0057Leucine Rich
Repeat
1418LRR 8/10230-2539.70.71Leucine Rich
Repeat
1418LRR 9/10255-27712.70.096Leucine Rich
Repeat
1418LRRNT1/136-6640.51.7e−09Leucine rich
repeat N-
terminal domain
1419AhpC-TSA1/1 81-230247.71.6e−70AhpC/TSA family
1419Syndecan1/118-496.40.062Syndecan domain
1421Triabin1/1120-13517.70.00038Triabin
1421lipocalin1/1 41-185111.92.6e−31Lipocalin/
cytosolic
fatty-acid
binding pr
1422Ribosomal_L21e1/1 2-100241.61.1e−68Ribosomal
protein L21e
1423Ribosomal_S101/1 19-114193.72.8e−54Ribosomal
protein
S10p/S20e
1424Ribosomal_L231/1 74-153112.45e−32Ribosomal
protein L23
1424Ribosomal_L23eN1/115-6863.21.3e−16Ribosomal
protein L23, N-
terminal dom
1425DUF4351/1 98-383445.35.3e−130Membrane
protein of
unknown
function (D
1427FeoB1/1247-26212.00.0065Ferrous iron
transport
protein B
1427MMR_HSR11/1118-393172.09.9e−48GTPase of
unknown
function
1429Peptidase_C131/1 6-327698.14.2e−206Peptidase C13
family
1430ER_lumen_recept1/1 1-202527.31.1e−154ER lumen
protein
retaining
receptor
1431COLFI1/11149-1365538.46.8e−210Fibrillar
collagen C-
terminal domain
1431Collagen 1/1933-7226.58.5e−06Collagen triple
helix repeat
(20 copies)
1431Collagen10/19529-56730.18.6e−07Collagen triple
helix repeat
(20 copies)
1431Collagen11/19568-62747.11.9e−11Collagen triple
helix repeat
(20 copies)
1431Collagen12/19628-68749.24.9e−12Collagen triple
helix repeat
(20 copies)
1431Collagen13/19691-75061.71.8e−15Collagen triple
helix repeat
(20 copies)
1431Collagen14/19751-81045.74.5e−11Collagen triple
helix repeat
(20 copies)
1431Collagen15/19811-87042.82.7e−10Collagen triple
helix repeat
(20 copies)
1431Collagen16/19874-93360.05.3e−15Collagen triple
helix repeat
(20 copies)
1431Collagen17/19934-99041.18.1e−10Collagen triple
helix repeat
(20 copies)
1431Collagen18/19 991-105051.51.1e−12Collagen triple
helix repeat
(20 copies)
1431Collagen19/191051-110540.41.3e−09Collagen triple
helix repeat
(20 copies)
1431Collagen 2/19 90-14742.63.1e−10Collagen triple
helix repeat
(20 copies)
1431Collagen 3/19148-20759.95.6e−15Collagen triple
helix repeat
(20 copies)
1431Collagen 4/19208-26748.57.5e−12Collagen triple
helix repeat
(20 copies)
1431Collagen 5/19268-32752.46.6e−13Collagen triple
helix repeat
(20 copies)
1431Collagen 6/19328-38754.71.5e−13Collagen triple
helix repeat
(20 copies)
1431Collagen 7/19388-41519.40.00075Collagen triple
helix repeat
(20 copies)
1431Collagen 8/19418-46540.71.1e−09Collagen triple
helix repeat
(20 copies)
1431Collagen 9/19469-52855.68.3e−14Collagen triple
helix repeat
(20 copies)
1432DJ-1_PfpI1/1 4-173203.71.7e−57DJ-1/PfpI
family
1433Gastrin1/1 2-115198.21.3e−55Gastrin/cholecy
stokinin family
1435LRR1/741-6314.20.038Leucine Rich
Repeat
1435LRR2/764-8613.80.049Leucine Rich
Repeat
1435LRR3/7 87-10911.70.19Leucine Rich
Repeat
1435LRR4/7110-13413.60.055Leucine Rich
Repeat
1435LRR5/7135-15715.60.015Leucine Rich
Repeat
1435LRR6/7158-18013.40.061Leucine Rich
Repeat
1435LRR7/7181-20317.70.0039Leucine Rich
Repeat
1436DUF4351/1 62-348516.02.7e−151Membrane
protein of
unknown
function
(DUF435
1437asp1/1 39-427645.92.2e−190Eukaryotic
aspartyl
protease
1438Clq1/1123-247251.98.8e−72Clq domain
1438Collagen1/233-6827.25.4e−06Collagen triple
helix repeat
(20 copies)
1438Collagen2/2 69-11424.23.5e−05Collagen triple
helix repeat
(20 copies)
1439ras1/1 7-193319.39.6e−94Ras family
1440Rho_GDI1/1 1-201502.63e−147RHO protein GDP
dissociation
inhibitor
1441Clathrin_lg_ch1/2 3-162294.21.7e−84Clathrin light
chain
1441Clathrin_lg_ch2/2163-217124.02.7e−33Clathrin light
chain
1441Myc-LZ1/1 98-1308.40.85Myc leucine
zipper domain
1443HMG_box1/2 6-7963.43.4e−16HMG (high
mobility group)
box
1443HMG_box2/2 95-163129.75.5e−35HMG (high
mobility group)
box
1444IBN_NT1/131-9724.82.7e−05Importin-beta
N-terminal
domain
1445EGF1/1146−18123.85.2e−05EGF-like domain
1447Spermine_synth1/1109-366384.77e−116Spermine/spermidine
synthase
1449ig1/1 34-11614.20.029Immunoglobulin
domain
1451Ribosomal_S61/1 3-9617.80.00053Ribosomal
protein S6
1453Ribosomal_S171/1 75-145149.14e−43Ribosomal
protein S17
1454DUF1961/1 87-1067.30.84Uncharacterized
ACR, COG1343
1454ras1/1 13-206381.53e−112Ras family
1455Folate_rec1/1 6-249561.27e−165Folate receptor
family
1458serpin1/1139-498455.74.5e−134Serpin (serine
protease
inhibitor)
1459cytochrome_b_C1/1258-359152.38.2e−42Cytochrome b(C-
terminal)/b6/pe
tD
1459cytochrome_b_N1/1 1-204376.51e−115Cytochrome b(N-
terminal)/b6/pe
tB
1460Ribosomal_L32e1/1 16-125267.61.4e−83Ribosomal
protein L32
1462ECH1/1 68-248150.02.2e−43Enoyl-CoA
hydratase/isomerase
family
1463filament1/1 83-394595.82.5e−175Intermediate
filament
protein
1464DEAD1/215-6252.14.7e−15DEAD/DEAH box
helicase
1464DEAD2/2281-44493.87.2e−28DEAD/DEAH box
helicase
1464SPRY1/1130-246121.02e−32SPRY domain
1464helicase_C1/1539-610108.32.6e−29Helicase
conserved C-
terminal domain
1465IGFBP1/137-9413.40.017Insulin-like
growth factor
binding protein
1465PDZ1/1370-46550.85.4e−13PDZ domain
(Also known as
DHR or GLGF)
1465kazal1/1109-15529.48.9e−06Kazal-type
serine protease
inhibitor
domain
1465trypsin1/1205-36474.57.7e−23Trypsin
1466zf-CCHC1/7 4-2132.63.4e−07Zinc knuckle
1466zf-CCHC2/752-6927.68.5e−06Zinc knuckle
1466Zf-CCHC3/772-8930.51.3e−06Zinc knuckle
1466zf-CCHC4/7 96-11331.85.4e−07Zinc knuckle
1466zf-CCHC5/7117-13430.81.1e−06Zinc knuckle
1466zf-CCHC6/7135-15228.25.8e−06Zinc knuckle
1466zf-CCHC7/7156-17331.37.9e−07Zinc knuckle
1467TIMP1/1 22-194472.63.7e−172Tissue
inhibitor of
metalloproteinase
1468efhand1/527-5521.10.00061EF hand
1468efhand3/5 94-12231.96.3e−07EF hand
1468efhand4/5130-15810.40.54EF hand
1468efhand5/5160-1769.80.82EF hand
1469KE21/1 23-130128.81e−34KE2 family
protein
1470Ribosomal_L111/1161-229106.55.2e−28Ribosomal
protein L11,
RNA binding do
1470Ribosomal_L11_N1/1 98-15693.41.1e−25Ribosomal
protein L11, N-
terminal dom
1471Mov341/1 4-118168.89.3e−47Mov34/MPN/PAD-1
family
1472Na_K-ATPase1/1 1-274477.97.9e−140Sodium/
potassium
ATPase beta
chain
1475hexapep1/326-4313.40.11Bacterial
transferase
hexapeptide
(four rep
1475hexapep3/3110-12712.80.16Bacterial
transferase
hexapeptide
(four rep
1476tubulin1/1 45-244374.81.4e−109Tubulin/FtsZ
family, GTPase
domain
1476tubulin_C1/1246-383270.91.7e−77Tubulin/FtsZ
family, C-
terminal domain
1477Calpain_inhib1/5 53-183179.01.5e−51Calpain
inhibitor
1477Calpain_inhib2/5186-317197.84.3e−57Calpain
inhibitor
1477Calpain_inhib3/5323-460221.06.8e−64Calpain
inhibitor
1477Calpain_inhib4/5466-597233.31.6e−67Calpain
inhibitor
1478DAD1/1 1-113258.55.9e−88DAD family
1479PSI1/1514-54213.00.0067Plexin repeat
1479Sema1/1 55-496841.82.3e−249Sema domain
1479ig1/1584-64522.30.00017Immunoglobulin
domain
1480Glyco_hydro_21/1226-327140.81.8e−43Glycosyl
hydrolases
family 2,
immunog
1480Glyco_hydro_2_C1/1329-631597.76.8e−176Glycosyl
hydrolases
family 2, TIM
bar
1480Glyco_hydro_2_N1/1 22-224379.73e−110Glycosyl
hydrolases
family 2, sugar b
1481F-box1/1232-27922.40.00033F-box domain
1481WD401/5359-39517.50.0035WD domain, G-
beta repeat
1481WD402/5398-43429.11.7e−06WD domain, G-
beta repeat
1483ras1/1 12-169221.69.4e−65Ras family
1484MHC_II_beta1/1 40-116164.61.7e−45Class II
histocompatibility
antigen,
1484ig1/1136-20140.61.4e−09Immunoglobulin
domain
1486Gal-bind_lectin1/1 5-137105.12.8e−29Galactoside-
binding lectin
1487NAP1/1 75-348644.55.8e−190Nucleosome
assembly
protein (NAP)
1488serpin1/1 24-398542.01.3e−159Serpin (serine
protease
inhibitor)
1489SRCR1/1 27-124129.92.4e−35Scavenger
receptor
cysteine-rich
domain
1490Ribosomal_L31/1 50-348664.84.5e−196Ribosomal
protein L3
1491tubulin1/1 49-246376.06.1e−110Tubulin/FtsZ
family, GTPase
domain
1491tubulin_C1/1248-393270.62e−77Tubulin/FtsZ
family, C-
terminal domain
1493efhand1/2127-15527.69.5e−06EF hand
1493efhand2/2163-19122.30.00029EF hand
1494HEAT 1/15 6-4214.20.015HEAT repeat
1494HEAT10/15357-39539.83.4e−10HEAT repeat
1494HEAT11/15396-43432.36e−08HEAT repeat
1494HEAT12/15435-47325.94.9e−06HEAT repeat
1494HEAT13/15474-51230.32.3e−07HEAT repeat
1494HEAT14/15513-55150.22.6e−13HEAT repeat
1494HEAT 2/1543-8024.11.6e−05HEAT repeat
1494HEAT 3/15 82-11926.33.8e−06HEAT repeat
1494HEAT 4/15120-15723.03.5e−05HEAT repeat
1494HEAT 5/15158-19644.61.3e−11HEAT repeat
1494HEAT 6/15197-23540.91.7e−10HEAT repeat
1494HEAT 7/15236-27433.52.6e−08HEAT repeat
1494HEAT 8/15275-31347.41.9e−12HEAT repeat
1494HEAT 9/15318-35628.76.9e−07HEAT repeat
1495ATP1G1_PLM_MAT81/1133-17770.51.7e−20ATP1G1/PLM/MAT8
family
1496PMP22_Claudin1/1 1-160297.81.3e−85PMP-
22/EMP/MP20/Claudin
family
1497BAH1/2755-880142.76.4e−39BAH domain
1497BAH2/2 966-1100137.62.2e−37BAH domain
1497DNA_methylase1/31139-123054.62.8e−14C-5 cytosine-
specific DNA
methylase
1497DNA_methylase2/31258-131731.76.7e−08C-5 cytosine-
specific DNA
methylase
1497DNA_methylase3/31519-159469.52.1e−18C-5 cytosine-
specific DNA
methylase
1497zf-CXXC1/1645-69187.46.3e−36CXXC zinc
finger
1498Adrenomedullin1/1 21-185433.51.9e−126Adrenomedullin
1499S_1001/1 5-4560.91.1e−15S-100/ICaBP
type calcium
binding domain
1499efhand2/251-7911.20.34EF hand
1500PMP22_Claudin1/1 3-180162.76.9e−46PMP-
22/EMP/MP20/Claudin
family
1501PNPase1/118-287.20.065Polyribonucleotide
nucleotidyltransferase,
1501RNase_PH1/1 31-166125.29.5e−353′
exoribonuclease
family, domain 1
1501RNase_PH_C1/1191-25842.41.1e−103′
exoribonuclease
family, domain 2
1502WD401/442-8035.13.6e−08WD domain, G-
beta repeat
1502WD402/4132-17024.24.4e−05WD domain, G-
beta repeat
1503homeobox1/119-6914.40.085Homeobox domain
1504Fe-ADH1/2 4-205121.34.4e−34Iron-containing
alcohol
dehydrogenase
1504Fe-ADH2/2228-29064.21.3e−17Iron-containing
alcohol
dehydrogenase
1505Ribosomal_L37ae1/1 2-92223.33.5e−63Ribosomal L37ae
protein family
1506HATPase_c1/1 35-18864.94.5e−17Histidine
kinase-, DNA
gyrase B-, and
HSP90
1506HSP901/1191-7241284.20Hsp90 protein
1507annexin1/4 35-10288.71.2e−22Annexin
1507annexin2/4107-174129.75.3e−35Annexin
1507annexin3/4191-25965.52.8e−16Annexin
1507annexin4/4267-334108.41.3e−28Annexin
1508Ribosomal_L31e1/1 16-110230.52.5e−71Ribosomal
protein L31e
1509Glyco_hydro_201/1200-518724.93.6e−214Glycosyl
hydrolase
family 20,
catalyt
1509Glyco_hydro_20b1/1 68-198245.76.3e−70Glycosyl
hydrolase
family 20,
domain
1510proteasome1/1 50-237183.32.9e−51Proteasome A-
type and B-type
1511CBS1/2112-16830.41.4e−06CBS domain
1511CBS2/2179-23241.41.4e−09CBS domain
1511FMN_dh1/1358-38715.50.00086FMN-dependent
dehydrogenase
1511IMPDH1/1 20-514683.51e−201IMP
dehydrogenase/
GMP reductase
1511NPD2/2359-39715.50.00081/2 52
91..140
1512Phage_terminase1/144-713.90.92Phage Terminase
1513LRR2/2232-25613.70.05Leucine Rich
Repeat
1513NTF21/2326-36227.63.3e−06Nuclear
transport
factor 2 (NTF2)
domain
1513NTF22/2397-47636.99.3e−09Nuclear
transport
factor 2 (NTF2)
domain
1513TAP_C1/1496-559141.03.9e−39TAP C-terminal
domain
1514CH1/1800-905110.24e−29Calponin
homology (CH)
domain
1515ig1/1 34-11512.60.079Immunoglobulin
domain
1516synaptobrevin1/1 2-90118.11.1e−31Synaptobrevin
1517zf-MYND1/111-349.70.079MYND finger
1518FAD_binding_61/1 48-155199.94.1e−56Oxidoreductase
FAD-binding
domain
1518NAD_binding_11/1176-290160.81.8e−44Oxidoreductase
NAD-binding
domain
1519HSP701/1 6-6121407.80Hsp70 protein
1520Glyco_hydro_201/1167-489702.52e−207Glycosyl
hydrolase
family 20,
catalyt
1520Glyco_hydro_20b1/1 35-165215.67.6e−61Glycosyl
hydrolase
family 20,
domain
1521rrm1/2 64-12379.56e−22RNA recognition
motif. (a.k.a.
RRM, RBD, or
1521rrm2/2143-20751.88.7e−14RNA recognition
motif. (a.k.a.
RRM, RBD, or
1522ferritin1/1 14-155194.02.3e−54Ferritin-like
domain
1523APG91/1230-608894.21.7e−268Autophagy
protein Apg9
1523Diphthamide_syn1/1552-5776.90.32Putative
diphthamide
synthesis
protei
1524Ribosomal_S151/1 61-151111.88.6e−31Ribosomal
protein S15
1525Herpes_HEPA1/110-243.40.86Herpesvirus DNA
helicase/primase
complex
1525actin1/1 1-377925.92.2e−281Actin
1526aldo_ket_red1/1 7-296529.89.4e−156Aldo/keto
reductase
family
1527p4501/1 48-488355.71.2e−110Cytochrome P450
1528Metallophos1/1199-46170.51.4e−17Calcineurin-
like
phosphoesterase
1529WD401/7 5-4434.26.2e−08WD domain, G-
beta repeat
1529WD402/753-9146.52e−11WD domain, G-
beta repeat
1529WD403/7 95-13350.71.3e−12WD domain, G-
beta repeat
1529WD404/7138-17840.31.2e−09WD domain, G-
beta repeat
1529WD405/7182-22037.76.3e−09WD domain, G-
beta repeat
1529WD406/7224-26022.50.00013WD domain, G-
beta repeat
1529WD407/7273-31121.60.00024WD domain, G-
beta repeat
1530Ribosomal_L7Ae1/1 20-114114.87.2e−33Ribosomal
protein
L7Ae/L30e/S12e/
Gadd4
1531cpn60_TCP11/1 32-524583.99.7e−172TCP-1/cpn60
chaperonin
family
1532CUB1/2 23-13879.92.7e−22CUB domain
1532CUB2/2193-302160.55.2e−46CUB domain
1532EGF1/1161-18917.90.0023EGF-like domain
1532sushi2/3309-37145.52.8e−10Sushi domain
(SCR repeat)
1532sushi3/3376-44750.71.2e−11Sushi domain
(SCR repeat)
1532trypsin1/1464-697189.71.7e−59Trypsin
1533CUB1/2 18-12771.86.9e−20CUB domain
1533CUB2/2175-287150.54.7e−43CUB domain
1533EGF1/1135-17133.59.3e−08EGF-like domain
1533sushi1/2294-35453.32.6e−12Sushi domain
(SCR repeat)
1533sushi2/2359-42153.52.2e−12Sushi domain
(SCR repeat)
1533trypsin1/1438-675217.23.1e−68Trypsin
1534Ndr1/1 40-322644.17.5e−190Ndr family
1534abhydrolase1/2 95-17811.70.013alpha/beta
hydrolase fold
1535RrnaAD1/1111-1475.20.78Ribosomal RNA
adenine
dimethylase
1535efhand1/412-4039.64.8e−09EF hand
1535efhand2/448-7638.41e−08EF hand
1535efhand3/4 85-11342.19.8e−10EF hand
1535efhand4/4121-14941.21.7e−09EF hand
1536calreticulin1/1 21-332774.02.2e−238Calreticulin
family
1537S_1001/1 5-4888.61.2e−23S-100/ICaBP
type calcium
binding domain
1537efhand1/154-8217.20.0073EF hand
1538UPAR_LY61/126-96114.12.7e−30u-PAR/Ly-6
domain
1539Cys_knot1/1 22-130187.91.7e−52Cystine-knot
domain
1540Kunitz_BPTI1/3 54-10488.89.4e−28Kunitz/Bovine
pancreatic
trypsin
inhibito
1540Kunitz_BPTI2/3125-17588.21.5e−27Kunitz/Bovine
pancreatic
trypsin
inhibito
1540Kunitz_BPTI3/3217-26790.82.1e−28Kunitz/Bovine
pancreatic
trypsin
inhibito
1541Ribosomal_L13e1/1 7-185463.81.4e−135Ribosomal
protein L13e
1542GILT1/1 62-17088.81.1e−22Gamma
interferon
inducible
lysosomal thiolr
1543HSP201/1 60-162164.42e−45Hsp20/alpha
crystallin
family
1543crystallin1/1 1-59136.23.7e−38Alpha
crystallin A
chain, N
terminal
1544CK_II_beta1/1 5-183508.16.6e−149Casein kinase
II regulatory
subunit
1545fn1 1/12 81-11664.81.2e−16Fibronectin
type I domain
1545fn110/122204-224377.53e−20Fibronectin
type I domain
1545fn111/122249-228672.39e−19Fibronectin
type I domain
1545fn112/122293-232862.07.5e−16Fibronectin
type I domain
1545fn1 2/12126-16473.93.1e−19Fibronectin
type I domain
1545fn1 3/12170-20867.91.5e−17Fibronectin
type I domain
1545fn1 4/12215-25480.44.5e−21Fibronectin
type I domain
1545fn1 5/12260-29976.94.4e−20Fibronectin
type I domain
1545fn1 6/12337-37151.47.8e−13Fibronectin
type I domain
1545fn1 7/12499-53777.04.2e−20Fibronectin
type I domain
1545fn1 8/12547-58463.82.3e−16Fibronectin
type I domain
1545fn1 9/12590-62871.31.7e−18Fibronectin
type I domain
1545fn21/2389-43094.27.6e−35Fibronectin
type II domain
1545fn22/2449-490100.14.1e−37Fibronectin
type II domain
1545fn3 1/16637-72053.07.5e−14Fibronectin
type III domain
1545fn310/161477-1559101.67e−28Fibronectin
type III domain
1545fn311/161571-165081.64.1e−22Fibronectin
type III domain
1545fn312/161661-174062.31.5e−16Fibronectin
type III domain
1545fn313/161751-183079.02.3e−21Fibronectin
type III domain
1545fn314/161843-192183.01.7e−22Fibronectin
type III domain
1545fn315/161932-201192.82.4e−25Fibronectin
type III domain
1545fn316/162102-217931.51.2e−07Fibronectin
type III domain
1545fn3 2/16749-82959.78.8e−16Fibronectin
type III domain
1545fn3 3/16840-91896.02.8e−26Fibronectin
type III domain
1545fn3 4/16 936-101584.65.8e−23Fibronectin
type III domain
1545fn3 5/161026-110480.68.3e−22Fibronectin
type III domain
1545fn3 6/161125-119132.65.9e−08Fibronectin
type III domain
1545fn3 7/161203-128574.54.7e−20Fibronectin
type III domain
1545fn3 8/161296-137682.91.8e−22Fibronectin
type III domain
1545fn3 9/161387-146686.12.2e−23Fibronectin
type III domain
1546p4501/1 52-511482.42.7e−150Cytochrome P450
1548GTP_EFTU1/1 5-239376.42.9e−109Elongation
factor Tu GTP
binding domain
1548GTP_EFTU_D21/1251-327100.68e−27Elongation
factor Tu
domain 2
1548GTP_EFTU_D31/1333-442213.33.5e−60Elongation
factor Tu C-
terminal domain
1549fibrinogen_C1/1175-415532.04.2e−156Fibrinogen beta
and gamma
chains, C-t
1550PX1/165-178106.74.6e−28PX domain
1551lectin_c1/1114-22248.82.9e−11Lectin C-type
domain
1552lipocalin1/1 32-178129.61.8e−36Lipocalin/
cytosolic
fatty-acid
binding pr
1553enolase1/1142-432717.18.3e−212Enolase, C-
terminal TIM
barrel domain
1553enolase_N1/1 2-134280.03.1e−80Enolase, N-
terminal domain
1554p4501/1 44-498543.81.6e−169Cytochrome P450
1555Ribosomal_S3Ae1/1 12-222518.55e−152Ribosomal S3Ae
family
1556ldl_recept_a1/334-6124.85.7e−06Low-density
lipoprotein
receptor domain
1556ldl_recept_a3/3105-14145.13.8e−12Low-density
lipoprotein
receptor domain
1557Glyco_hydro_311/1194-9181402.00Glycosyl
hydrolases
family 31
1557trefoil1/1 81-13053.42.2e−13Trefoil (P-
type) domain
1558globin1/1 3-147218.11.3e−61Globin
1559ANATO1/1 96-1025.50.18Anaphylotoxin-
like domain
1559fn33/4429-51613.00.027Fibronectin
type III domain
1559fn34/4527-60933.72.8e−08Fibronectin
type III domain
1560IGFBP1/140-9997.42e−26Insulin-like
growth factor
binding pr
1560thyroglobulin_11/1213-285119.65.9e−32Thyroglobulin
type-1 repeat
1561IGFBP1/130-8986.82.1e−23Insulin-like
growth factor
binding pr
1561thyroglobulin_11/1176-251144.32.1e−39Thyroglobulin
type-1 repeat
1562histone1/1 17-135100.33.6e−27Core histone
H2A/H2B/H3/H4
1563MHC_I1/1 22-200473.51.7e−138Class I
Histocompatibility
antigen,
domains
1563ig1/1217-28236.61.7e−08Immunoglobulin
domain
1564AT_hook1/1244-25612.00.12AT hook motif
1564Ets1/1272-357127.68.8e−35Ets-domain
1564SAM_PNT1/1 48-132123.54.9e−35Sterile alpha
motif
(SAM)/Pointed
domain
1565MHC_I1/1 25-203481.85.6e−141Class I
Histocompatibility
antigen,
domains
1565ig1/1220-28533.31.4e−07Immunoglobulin
domain
1566ubiquitin1/2 3-7828.42e−06Ubiquitin
family
1566ubiquitin2/2 82-15584.43.8e−22Ubiquitin
family
1567C21/2310-39692.23.8e−25C2 domain
1567C22/2461-53930.42.6e−07C2 domain
1568EMP24_GP25L1/1 8-211142.67.2e−39emp24/gp25L/p24
family
1569DSPc1/1173-311261.61.1e−74Dual
specificity
phosphatase,
catalytic
1569Rhodanese1/1 9-13192.16e−26Rhodanese-like
domain
1569Y_phosphatase1/1237-29019.80.00013Protein-
tyrosine
phosphatase
1570Ribosomal_S17e1/1 1-122305.62.5e−95Ribosomal S17
1571proteasome1/1 29-215145.91.4e−40Proteasome A-
type and B-type
1572TCTP1/1 1-135287.44.2e−87Translationally
controlled
tumor prot
1573HATPase_c1/1 1-9627.51.8e−06Histidine
kinase-, DNA
gyrase B-, and H
1573HSP901/1 99-6351270.10Hsp90 protein
1574Alpha_adaptin_C1/1226-2376.30.25Alpha adaptin
AP2, C-terminal
domain
1574Amino_oxidase1/1 23-460326.92.3e−94Flavin
containing
amine
oxidoreductas
1574DAO1/114-4621.09.2e−05FAD dependent
oxidoreductase
1574FAD_binding_31/116-4831.17.2e−09FAD binding
domain
1574GMC_oxred1/114-448.10.11GMC
oxidoreductase
1574Thi41/115-4514.80.00093Thi4 family
1574TrkA-N1/115-4313.20.037TrkA-N domain
1574pyr_redox1/115-5021.81.6e−05Pyridine
nucleotide-
disulphide
oxidor
1575MHC_I1/1 25-203482.43.5e−141Class I
Histocompatibility
antigen,
domains
1575ig1/1220-28536.32.2e−08Immunoglobulin
domain
1576MHC_II_alpha1/1 29-109158.01.4e−46Class II
histocompatibility
antigen,
alp
1576ig1/1125-19032.03.4e−07Immunoglobulin
domain
1577NDK1/1 5-152396.92e−115Nucleoside
diphosphate
kinase
1578AAA1/1140-15712.40.01ATPase family
associated with
various ce
1578ras1/2140-15414.40.0034Ras family
1578ras2/2213-32196.71.2e−27Ras family
1579Ribosomal_L10e1/1 1-176465.43.7e−138Ribosomal L10
1580RHD1/1 18-186416.36.5e−125Rel homology
domain (RHD)
1580TIG1/1194-28980.14.5e−20IPT/TIG domain
1581serpin1/1 28-402583.75.8e−172Serpin (serine
protease
inhibitor)
1582PCNA1/1 1-125319.73.3e−92Proliferating
cell nuclear
antigen, N-
termin
1582PCNA_C1/1127-254317.21.9e−91Proliferating
cell nuclear
antigen, C-
termin
1583Herpes_glycop_D1/1352-3867.70.43Herpesvirus
glycoprotein D
1583ig1/3 43-11019.40.001Immunoglobulin
domain
1583ig2/3165-20918.50.0018Immunoglobulin
domain
1583ig3/3251-32826.98.5e−06Immunoglobulin
domain
1584WD402/6 84-1239.00.94WD domain, G-
beta repeat
1585ig1/4 85-12110.10.39Immunoglobulin
domain
1585ig3/4255-31216.30.0076Immunoglobulin
domain
1585ig4/4347-39632.32.7e−07Immunoglobulin
domain
1586lipocalin1/1 4-134110.66e−31Lipocalin/
cytosolic
fatty-acid
binding pr
1587Grp1_Fun34_YaaH1/1557-5756.30.3GPR1/FUN34/yaaH
family
1587IGA11/163-815.60.59Immunoglobulin
A1 protease
1587ig1/435-8513.50.043Immunoglobulin
domain
1587ig2/4217-28031.44.9e−07Immunoglobulin
domain
1587ig4/4412-48722.30.00016Immunoglobulin
domain
1587pkinase1/1582-910253.72.5e−72Protein kinase
domain
1588RNA_pol_Rpb7_N1/1 1-77135.32.5e−39RNA polymerase
Rpb7, N-
terminal domain
1588S11/1 78-16169.41.4e−17S1 RNA binding
domain
1590GATase1/1204-2498.30.33Glutamine
amidotransferase
class-I
1591Ribosomal_S21/1 18-186340.51.8e−98Ribosomal
protein S2
1592Gelsolin1/6 76-12664.76.4e−17Gelsolin repeat
1592Gelsolin2/6198-23870.61.3e−18Gelsolin repeat
1592Gelsolin3/6314-35662.23.2e−16Gelsolin repeat
1592Gelsolin4/6453-50473.61.7e−19Gelsolin repeat
1592Gelsolin5/6576-61642.91.1e−10Gelsolin repeat
1592Gelsolin6/6679-72163.41.5e−16Gelsolin repeat
1593ion_trans1/1239-41059.65.4e−15Ion transport
protein
1594ig1/2148-20624.54.1e−05Immunoglobulin
domain
1594ig2/2256-31025.32.4e−05Immunoglobulin
domain
1595DUF2581/115-306.40.79Protein of
unknown
function,
DUF258
1595ras1/1 13-218366.49.7e−108Ras family
1596Exonuc_V_gamma1/1187-2295.00.51Exodeoxyribonuclease
V, gamma
subunit
1596Ribosomal_S6e1/1 1-127312.16.7e−90Ribosomal
protein S6e
1597IL81/123-9047.36.7e−12Small cytokines
(intecrine/chemokine),
inter
1598Exo_endo_phos1/1 8-237141.21.9e−38Endonuclease/Exonuclease/
phosphatase
fa
1598rvt1/1508-773263.03.9e−75Reverse
transcriptase
(RNA-dependent
DN
1599Mov341/1 26-139173.82.9e−48Mov34/MPN/PAD-1
family
1600histone1/1 19-137100.33.6e−27Core histone
H2A/H2B/H3/H4
16012-Hacid_DH1/1 44-137133.72.6e−36D-isomer
specific 2-
hydroxyacid
dehydrog
16012-Hacid_DH_C1/1139-320199.84.1e−81D-isomer
specific 2-
hydroxyacid
dehydrog
1601PDH1/1187-2138.10.35Prephenate
dehydrogenase
1602GST_C1/1127-21711.90.048Glutathione S-
transferase, C-
terminal
1603proteasome1/1 31-217238.31.1e−67Proteasome A-
type and B-type
1604Ribosomal_S81/1 5-130192.16.6e−58Ribosomal
protein S8
1605PAE1/1 17-1027.40.2Pectinacetylest
erase
1606PCI1/1328-40880.57.2e−22PCI domain
1607Ribosomal_L6e1/1181-288251.08e−73Ribosomal
protein L6e
1607Ribosomal_L6e_N1/134-96128.01.2e−36Ribosomal
protein L6, N-
terminal doma
1608EF1G_domain1/1275-381303.52.3e−87Elongation
factor 1 gamma,
conserved dom
1608GST_C1/1 86-198113.38.8e−31Glutathione S-
transferase, C-
terminal do
1608GST_N1/1 1-8189.11.9e−24Glutathione S-
transferase, N-
terminal do
1609CH1/1 25-13875.32e−19Calponin
homology (CH)
domain
1609calponin1/1175-20051.81.7e−14Calponin family
repeat
1610E71/11561-15706.30.41E7 protein,
Early protein
1610Glyco_hydro_161/11773-18029.30.15Glycosyl
hydrolases
family 16
1610Mov341/12099-220599.95e−26Mov34/MPN/PAD-1
family
1610toxin_31/2955-9738.90.15
1611ATP-bind1/1488-5266.90.49Conserved
hypothetical
ATP binding
protei
1611Ku_C1/1471-559143.14.9e−39Ku70/Ku80 C-
terminal arm
1611Ku_N1/1 37-256337.71.3e−97Ku70/Ku80 N-
terminal
alpha/beta
domain
1611SAP1/1573-60739.51.5e−09SAP domain
1611ku1/1261-468296.22.7e−92Ku70/Ku80 beta-
barrel domain
1612Nop1/1197-345201.61.2e−56Putative snoRNA
binding domain
16143Beta_HSD1/2 5-268.80.153-beta
hydroxysteroid
dehydrogenase/i
16143Beta_HSD2/2 84-1358.40.183-beta
hydroxysteroid
dehydrogenase/i
1614Epimerase1/1 5-341499.33e−146NAD dependent
epimerase/dehydratase f
1614adh_short1/1 1-3311.70.029short chain
dehydrogenase
1616ATP-synt_C1/1 67-135107.91.9e−28ATP synthase
subunit C
1618Flavi_NS2A1/1332-3548.30.74Flavivirus non-
structural
protein NS2A
1618Lamp1/1 1-354612.32.8e−180Lysosome-
associated
membrane
glycoprote
1618Peptidase_M501/1 3-3416.70.82Peptidase
family M50
1619A4_EXTRA1/1 42-204413.42e−209Amyloid A4
extracellular
domain
1619Coprogen_oxidas1/1164-1825.40.13Coproporphyrinogen
III oxidase
1619Kunitz_BPTI1/1310-36095.46.6e−30Kunitz/Bovine
pancreatic
trypsin inhi
1620Ribosomal_L301/1 88-14098.32.3e−28Ribosomal
protein
L30p/L7e
1621PX1/1 26-148128.21.5e−34PX domain
1622ig1/7 90-1099.40.59Immunoglobulin
domain
1622ig3/7245-31331.54.5e−07Immunoglobulin
domain
1622ig4/7359-40416.60.006Immunoglobulin
domain
1622ig6/7570-63831.64.4e−07Immunoglobulin
domain
1622ig7/7675-73345.65.8e−11Immunoglobulin
domain
1622pkinase1/1 827-1152259.73.8e−74Protein kinase
domain
1624zf-C3HC41/1521-5608.80.21Zinc finger,
C3HC4 type
(RING finger)
1625hormone61/1 21-116202.47e−57Glycoprotein
hormone
1626G-alpha1/1 13-393687.47.2e−203G-protein alpha
subunit
1626arf1/1213-29626.12.9e−06ADP-
ribosylation
factor family
1627rrm1/216-8684.22.5e−23RNA recognition
motif. (a.k.a.
RRM, RBD, or
1627rrm2/2107-17791.02.4e−25RNA recognition
motif. (a.k.a.
RRM, RBD, or
1628HMG_box1/1 1-3634.83.8e−08HMG (high
mobility group)
box
1629OEP1/1 92-1307.60.42Outer membrane
efflux protein
1629Ribosomal_L7Ae1/1122-216102.04.7e−29Ribosomal
protein
L7Ae/L30e/S12e/
Gadd4
1630Ribosomal_S24e1/1 23-105192.08.1e−55Ribosomal
protein S24e
1631SAPA1/221-5485.75.9e−33Saposin A-type
domain
1631SAPA2/2491-52478.16.4e−30Saposin A-type
domain
1631Surfactant_B2/3357-3899.80.11/3 240
272 . . . 4578
1632Tropomyosin2/2 48-284501.75.5e−147Tropomyosin
1633hormone1/1 12-227352.42.1e−130Somatotropin
hormone family
1635DSPc2/21806-18408.70.36Dual
specificity
phosphatase,
catalytic
1635Y_phosphatase1/21365-1596454.31.1e−132Protein-
tyrosine
phosphatase
1635Y_phosphatase2/21654-1887413.61.8e−120Protein-
tyrosine
phosphatase
1635fn31/8309-39173.78e−20Fibronectin
type III domain
1635fn32/8403-49066.59.6e−18Fibronectin
type III domain
1635fn33/8502-58470.56.7e−19Fibronectin
type III domain
1635fn34/8596-68669.31.5e−18Fibronectin
type III domain
1635fn35/8698-79958.71.7e−15Fibronectin
type III domain
1635fn36/8811-89450.44.3e−13Fibronectin
type III domain
1635fn37/8905-99067.06.8e−18Fibronectin
type III domain
1635ig1/337-9929.71.4e−06Immunoglobulin
domain
1635ig2/3139-19923.29.1e−05Immunoglobulin
domain
1635ig3/3236-29026.71e−05Immunoglobulin
domain
1636ATP-synt_ab1/1138-421550.01.5e−161ATP synthase
alpha/beta
family, nucleot
1636ATP-synt_ab_C1/1423-531138.79.9e−39ATP synthase
alpha/beta
chain, C termin
1636ATP-synt_ab_N1/1 67-13574.51e−23ATP synthase
alpha/beta
family, beta-ba
1637S_1001/1 8-5187.91.9e−23S-100/ICaBP
type calcium
binding domain
1637efhand1/158-8623.80.00011EF hand
1638GLTT1/140-687.60.44GLTT repeat (6
copies)
1639PGK1/1 2-4181017.13.9e−302Phosphoglycerate
kinase
1640C21/8 2-8587.21.1e−23C2 domain
1640C22/8222-30252.51.1e−13C2 domain
1640C23/8381-47966.01.4e−17C2 domain
1640C24/81154-124490.31.3e−24C2 domain
1640C25/81338-142117.40.0014C2 domain
1640C26/81580-166379.22.2e−21C2 domain
1640C28/81904-192615.30.0059C2 domain
1641RNA_pol_A1/2246-8951289.30RNA polymerase
alpha subunit
1641RNA_pol_A21/11060-1477762.02.4e−225RNA polymerase
A/beta′/A″
subunit
1643HATPase_c1/1 96-25454.73.4e−14Histidine
kinase-, DNA
gyrase B-, and
HSP90
1643HSP901/1257-7831105.00Hsp90 protein
1644Ribosomal_L40e1/1 77-128111.51.6e−29Ribosomal L40e
family
1644ubiquitin1/1 1-74153.14.8e−42Ubiquitin
family
1646Ribosomal_S131/114-142274.71.2e−78Ribosomal
protein S13/S18
1647Ribosomal_L51/110-6387.82.2e−22Ribosomal
protein L5
1647Ribosomal_L5_C1/1 67-166210.11.7e−62ribosomal L5P
family C-
terminus
1648Armadillo_seg1/21017-104410.70.3Armadillo/beta-
catenin-like
repeat
1649ig1/1 38-10233.81e−07Immunoglobulin
domain
1650ICE_p101/1244-329180.72.3e−50ICE-like
protease
(caspase) p10
domain
1650ICE_p201/1 88-219293.95.7e−88ICE-like
protease
(caspase) p20
domain
1650TAF1/1133-1434.81TATA box
binding protein
associated
factor (
1651Ribosomal_L61/212-8784.51.9e−22Ribosomal
protein L6
1651Ribosomal_L62/2 99-17866.82e−17Ribosomal
protein L6
1652Ribosomal_S121/1 7-142279.83.4e−80Ribosomal
protein S12
1653ubiquitin1/1 1-74116.34.1e−31Ubiquitin
family
1654Fragilysin1/1212-23811.40.019Fragilysin
metallopeptidase
(M10C) en
1654Peptidase_M101/1 98-204163.63.3e−45Matrixin
1654Peptidase_M10_N1/175-8410.20.014Matrix
metalloprotease,
N-terminal do
1654hemopexin1/4298-34158.53.3e−16Hemopexin
1654hemopexin2/4343-38448.63.6e−13Hemopexin
1654hemopexin3/4387-43454.27.1e−15Hemopexin
1654hemopexin4/4436-48053.41.3e−14Hemopexin
1655Sec61_beta1/149-9498.92.4e−26Sec61beta
family
1656ras1/1 66-13436.77.9e−10Ras family
1657Hist_deacetyl1/1 681-1028374.21.3e−108Histone
deacetylase
family
1658RA1/1648-73597.52.6e−25Ras association
(RalGDS/AF-6)
domain
1658RasGEF1/1240-462194.31.9e−54RasGEF domain
1658RasGEFN1/1 86-14031.42.4e−07Guanine
nucleotide
exchange factor
for Ras-l
1659UPF00231/1 5-244332.74.1e−96Uncharacterized
protein family
UPF0023
1660NNMT_PNMT_TEMT1/1 1-259593.31.5e−174NNMT/PNMT/TEMT
family
1661KH1/147-9522.76e−05KH domain
1661Ribosomal_S3_C1/1104-188112.82.6e−34Ribosomal
protein S3, C-
terminal domai
1663Neurokinin_B1/1 1-55126.02.2e−37Neurokinin B
1664ig1/4 85-1219.20.71Immunoglobulin
domain
1664ig2/4162-2198.80.89Immunoglobulin
domain
1664ig3/4255-31218.40.0019Immunoglobulin
domain
1664ig4/4347-39630.77.8e−07Immunoglobulin
domain
1665Ran_BP11/1 37-161306.14.3e−88RanBP1 domain
1666bromodomain1/1136-223128.75e−36Bromodomain
1668WD401/2171-20512.40.098WD domain, G-
beta repeat
1669BRICHOS1/1 68-164144.01.7e−40BRICHOS domain
1670Osteopontin1/1 1-184.60.78Osteopontin
1670TILa1/1433-4558.80.41TILa domain
1670efhand1/1626-65410.90.4EF hand
1670kazal1/2456-50971.91.3e−17Kazal-type
serine protease
inhibitor doma
1671adh_short1/1 2-288223.82.5e−63short chain
dehydrogenase
1672Peptidase_C11/1114-332442.95.2e−132Papain family
cysteine
protease
1673SNF1/1 52-5971309.00Sodium: neurotransmitter
symporter
family
1674Gal-bind_lectin1/1 5-137103.21e−28Galactoside-
binding lectin
1675helicase_C1/1382-47753.79.4e−14Helicase
conserved C-
terminal domain
1676Ribosomal_L7Ae1/1 16-111143.02.8e−41Ribosomal
protein
L7Ae/L30e/S12e/
Gadd4
1677GST_C1/1 83-192106.01e−28Glutathione S-
transferase, C-
terminal domain
1677GST_N1/1 4-77100.01.3e−27Glutathione S-
transferase, N-
terminal domain
1678Peptidase_S261/1 86-244185.17.9e−56Signal
peptidase I
1679DNA_pol_delta_41/1 1-107207.19.2e−63DNA polymerase
delta, subunit 4
1680Rhomboid1/1 99-25078.66.6e−21Rhomboid family
1683ras1/1 24-217301.22.2e−88Ras family
1684Synaptophysin1/1 35-260245.28.9e−70Synaptophysin/
synaptoporin
1685Pep_M12B_propep1/1 88-204200.23.2e−56Reprolysin
family
propeptide
1685Reprolysin1/1220-414367.11.9e−106Reprolysin
(M12B) family
zinc metallo
1685disintegrin1/1431-50782.23.1e−26Disintegrin
1686transmembrane41/1 70-316332.61e−103Tetraspanin
family
1688MBD1/1207-260100.14.5e−26Methyl-CpG
binding domain
1689Sm1/1 43-12263.71.2e−16Sm protein
1691pkinase1/2162-383183.14.5e−51Protein kinase
domain
1691pkinase2/2455-48222.92.9e−05Protein kinase
domain
|
Example 5
eMatrix Annotation of Polypeptides of the Invention
Using the eMATRIX software package (Stanford University, Stanford, Calif.) (Wu et al., J. Comp. Biol., vol. 6, pp. 219-235 (1999), herein incorporated by reference), the polypeptides of the invention (SEQ ID NO 853 through 1704) we analyzed. The following table describes the polypeptides of the invention that have significant eMatrix hits:
TABLE 4
|
|
SEQ ID NO:Domain_IDScorep-valueDomain_positionModel_IDModel_Description
|
|
856BL01115A10.226.705e−10 7-50BL01115GTP-binding nuclear
protein ran proteins.
856BL01115B10.817.308e−09 87-130BL01115GTP-binding nuclear
protein ran proteins.
856PR00449A13.203.045e−17 7-28PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
856PR00449B14.346.318e−1130-46PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
856PR00449C17.272.895e−1847-69PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
856PR00449D10.792.800e−15109-122PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
856PR00449E13.509.100e−16157-179PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
857BL00222C22.971.333e−2638-65BL00222Insulin-like growth
factor binding
proteins.
857BL00484B9.042.385e−1539-52BL00484Thyroglobulin type-1
repeat proteins
proteins.
857BL00484C17.017.158e−1563-77BL00484Thyroglobulin type-1
repeat proteins
proteins.
860BL0019412.163.348e−1386-98BL00194Thioredoxin family
proteins.
860PR00421B11.402.241e−11 93-102PR00421THIOREDOXIN FAMILY
SIGNATURE
860PR00421C13.605.500e−09136-147PR00421THIOREDOXIN FAMILY
SIGNATURE
861BL00288A17.472.059e−3664-93BL00288Tissue inhibitors of
metalloproteinases
proteins.
861BL00288B9.447.000e−15108-118BL00288Tissue inhibitors of
metalloproteinases
proteins.
861BL00288C14.626.500e−18127-141BL00288Tissue inhibitors of
metalloproteinases
proteins.
861BL00288D25.761.000e−40151-195BL00288Tissue inhibitors of
metalloproteinases
proteins.
861BL00288E17.241.667e−26197-219BL00288Tissue inhibitors of
metalloproteinases
proteins.
862BL00229A23.579.182e−09216-254BL00229Tau and MAP proteins
tubulin-binding domain
proteins.
862BL00412D16.543.296e−09175-225BL00412Neuromodulin (GAP-43)
proteins.
862BL00412D16.544.398e−09103-153BL00412Neuromodulin (GAP-43)
proteins.
862BL00412D16.544.717e−10107-157BL00412Neuromodulin (GAP-43)
proteins.
862BL00412D16.545.684e−09128-178BL00412Neuromodulin (GAP-43)
proteins.
862BL00412D16.549.724e−09 90-140BL00412Neuromodulin (GAP-43)
proteins.
862BL00826C7.636.400e−09197-223BL00826MARCKS family proteins.
863BL01033A16.943.250e−2044-65BL01033Globins profile.
863BL01033B13.817.000e−14106-117BL01033Globins profile.
863PR00611A15.915.829e−0944-66PR00611ERYTHROCRUORIN FAMILY
SIGNATURE
863PR00612A8.645.800e−1434-46PR00612ALPHA HAEMOGLOBIN
SIGNATURE
863PR00612B10.921.000e−1351-61PR00612ALPHA HAEMOGLOBIN
SIGNATURE
863PR00612C12.162.286e−1366-75PR00612ALPHA HAEMOGLOBIN
SIGNATURE
863PR00612D9.763.400e−15 93-106PR00612ALPHA HAEMOGLOBIN
SIGNATURE
863PR00612E9.047.000e−19141-157PR00612ALPHA HAEMOGLOBIN
SIGNATURE
864BL00077A19.446.478e−34 5-45BL00077Heme-copper oxidase
catalytic subunit,
copper B binding regio.
864BL00077B10.157.750e−36 67-112BL00077Heme-copper oxidase
catalytic subunit,
copper B binding regio.
864BL00077C18.981.000e−40127-177BL00077Heme-copper oxidase
catalytic subunit,
copper B binding regio.
864BL00077D11.171.000e−40200-254BL00077Heme-copper oxidase
catalytic subunit,
copper B binding regio.
864BL00077E13.715.179e−38265-313BL00077Heme-copper oxidase
catalytic subunit,
copper B binding regio.
864BL00077F11.351.000e−40348-398BL00077Heme-copper oxidase
catalytic subunit,
copper B binding regio.
864BL00077G15.931.000e−40413-461BL00077Heme-copper oxidase
catalytic subunit,
copper B binding regio.
866BL00175A15.428.333e−2015-34BL00175Phosphoglycerate mutase
family phosphohistidine
proteins.
866BL00175B12.601.000e−1264-76BL00175Phosphoglycerate mutase
family phosphohistidine
proteins.
866BL00175C23.755.000e−25 88-119BL00175Phosphoglycerate mutase
family phosphohistidine
proteins.
866BL00175D27.678.500e−40173-224BL00175Phosphoglycerate mutase
family phosphohistidine
proteins.
870BL00478B14.796.870e−14300-314BL00478LIM domain proteins.
870PD002899.976.276e−0972-85PD00289PROTEIN SH3 DOMAIN
REPEAT PRESYNA.
873PD01922B21.837.328e−14251-286PD01922PROTEIN
PHOSPHODIESTERASE
HYDROL.
874BL00030A14.396.294e−11301-319BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
874BL00030B7.034.789e−09340-349BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
874BL000486.391.563e−09122-148BL00048Protamine P1 proteins.
874BL000486.391.563e−09123-149BL00048Protamine P1 proteins.
874BL000486.391.711e−10106-132BL00048Protamine P1 proteins.
874BL000486.391.947e−10117-143BL00048Protamine P1 proteins.
874BL000486.392.125e−11120-146BL00048Protamine P1 proteins.
874BL000486.393.025e−09121-147BL00048Protamine P1 proteins.
874BL000486.393.132e−10127-153BL00048Protamine P1 proteins.
874BL000486.393.813e−09110-136BL00048Protamine P1 proteins.
874BL000486.394.197e−10118-144BL00048Protamine P1 proteins.
874BL000486.395.725e−09108-134BL00048Protamine P1 proteins.
874BL000486.396.329e−10114-140BL00048Protamine P1 proteins.
874BL000486.396.566e−10116-142BL00048Protamine P1 proteins.
874BL000486.396.963e−09125-151BL00048Protamine P1 proteins.
874BL000486.397.039e−10119-145BL00048Protamine P1 proteins.
874BL000486.397.075e−09115-141BL00048Protamine P1 proteins.
874BL000486.397.395e−10112-138BL00048Protamine P1 proteins.
874BL000486.397.618e−12124-150BL00048Protamine P1 proteins.
874BL000486.397.638e−09126-152BL00048Protamine P1 proteins.
874BL000486.399.213e−09113-139BL00048Protamine P1 proteins.
874BL00970C14.809.168e−09 99-136BL00970Nuclear transition
protein 2 proteins.
874PR00308A5.904.646e−1014-28PR00308TYPE I ANTIFREEZE
PROTEIN SIGNATURE
874PR00308A5.904.706e−0916-30PR00308TYPE I ANTIFREEZE
PROTEIN SIGNATURE
874PR00308C3.838.831e−0917-26PR00308TYPE I ANTIFREEZE
PROTEIN SIGNATURE
874PR00308C3.838.892e−1018-27PR00308TYPE I ANTIFREEZE
PROTEIN SIGNATURE
874PR00308C3.838.892e−1019-28PR00308TYPE I ANTIFREEZE
PROTEIN SIGNATURE
874PR00308C3.838.892e−1020-29PR00308TYPE I ANTIFREEZE
PROTEIN SIGNATURE
874PR00833H2.306.250e−1015-29PR00833POLLEN ALLERGEN POA PI
SIGNATURE
875BL00226A12.774.484e−13181-195BL00226Intermediate filaments
proteins.
875BL00226B23.867.120e−33282-329BL00226Intermediate filaments
proteins.
875BL00226B23.868.744e−09233-280BL00226Intermediate filaments
proteins.
875BL00226C13.232.714e−24348-378BL00226Intermediate filaments
proteins.
875BL00226D19.102.216e−29451-497BL00226Intermediate filaments
proteins.
875BL00970B10.097.033e−0911-36BL00970Nuclear transition
protein 2 proteins.
879BL0028216.883.640e−09478-500BL00282Kazal serine protease
inhibitors family
proteins.
880BL5005827.239.654e−3317-64BL50058G-protein gamma subunit
profile.
880PR00321A11.916.727e−1416-31PR00321GAMMA G-PROTEIN
(TRANSDUCIN) SIGNATURE
880PR00321B12.623.647e−1432-46PR00321GAMMA G-PROTEIN
(TRANSDUCIN) SIGNATURE
880PR00321C15.398.816e−1652-69PR00321GAMMA G-PROTEIN
(TRANSDUCIN) SIGNATURE
881BL000369.023.571e−13331-343BL00036bZIP transcription
factors basic domain
proteins.
881BL000486.392.238e−09 6-32BL00048Protamine P1 proteins.
881BL000486.395.145e−10 5-31BL00048Protamine P1 proteins.
881PR00043A9.071.600e−25309-329PR00043JUN TRANSCRIPTION
FACTOR SIGNATURE
881PR00043B8.731.310e−22331-347PR00043JUN TRANSCRIPTION
FACTOR SIGNATURE
881PR00043C10.556.824e−16349-361PR00043JUN TRANSCRIPTION
FACTOR SIGNATURE
881PR00043D11.915.737e−17364-378PR00043JUN TRANSCRIPTION
FACTOR SIGNATURE
881PR00043E8.201.947e−18378-393PR00043JUN TRANSCRIPTION
FACTOR SIGNATURE
881PR00308C3.838.013e−09210-219PR00308TYPE I ANTIFREEZE
PROTEIN SIGNATURE
881PR00308C3.838.892e−10211-220PR00308TYPE I ANTIFREEZE
PROTEIN SIGNATURE
881PR00649B8.219.206e−10212-229PR00649GPR6 ORPHAN RECEPTOR
SIGNATURE
888PD002899.978.560e−10328-341PD00289PROTEIN SH3 DOMAIN
REPEAT PRESYNA.
888PF00424A14.346.266e−09236-267PF00424REV protein (anti-
repression
transactivator
protein).
889BL00226A12.774.960e−14158-172BL00226Intermediate filaments
proteins.
889BL00226B23.864.600e−33263-310BL00226Intermediate filaments
proteins.
889BL00226C13.238.125e−22328-358BL00226Intermediate filaments
proteins.
889BL00226D19.108.054e−29429-475BL00226Intermediate filaments
proteins.
889PR00581E3.486.494e−0946-61PR00581PROSTANOID EP2 RECEPTOR
SIGNATURE
891BL00406A9.951.000e−40 84-118BL00406Actins proteins.
891BL00406B5.471.000e−40160-214BL00406Actins proteins.
891PR00190A7.241.375e−13103-112PR00190ACTIN SIGNATURE
891PR00190B9.981.000e−15126-137PR00190ACTIN SIGNATURE
891PR00190C11.494.789e−30138-160PR00190ACTIN SIGNATURE
891PR00190D19.233.520e−24161-179PR00190ACTIN SIGNATURE
891PR00190E7.161.450e−19192-205PR00190ACTIN SIGNATURE
891PR00190F7.804.349e−21217-236PR00190ACTIN SIGNATURE
892PD02870B18.838.094e−11219-251PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
893BL00049A13.868.333e−1932-54BL00049Ribosomal protein L14
proteins.
893BL00049B18.426.806e−2467-98BL00049Ribosomal protein L14
proteins.
893BL00049C17.382.688e−28105-140BL00049Ribosomal protein L14
proteins.
893BL00049D13.475.765e−12142-152BL00049Ribosomal protein L14
proteins.
894BL01221A17.263.739e−27 73-100BL01221PMP-22/EMP/MP20
family proteins.
894BL01221B13.297.231e−14108-121BL01221PMP-22/EMP/MP20
family proteins.
894BL01221A17.263.739e−27 73-100BL01221PMP-22/EMP/MP20
family proteins.
894BL01221B13.297.231e−14108-121BL01221PMP-22/EMP/MP20
family proteins.
894BL01221C26.208.333e−38131-175BL01221PMP-22/EMP/MP20
family proteins.
894BL01221C26.208.405e−11128-172BL01221PMP-22/EMP/MP20
family proteins.
894BL01221D13.997.577e−28202-228BL01221PMP-22/EMP/MP20
family proteins.
895BL00123A10.806.786e−28 77-101BL00123Alkaline phosphatase
proteins.
895BL00123B19.311.900e−40115-157BL00123Alkaline phosphatase
proteins.
895BL00123C24.611.000e−40170-219BL00123Alkaline phosphatase
proteins.
895BL00123D12.735.263e−15241-253BL00123Alkaline phosphatase
proteins.
895BL00123E22.251.000e−40329-382BL00123Alkaline phosphatase
proteins.
895BL00123F19.036.625e−33389-423BL00123Alkaline phosphatase
proteins.
895BL00123G26.011.000e−40463-512BL00123Alkaline phosphatase
proteins.
895PR00113A11.749.182e−2577-97PR00113ALKALINE PHOSPHATASE
SIGNATURE
895PR00113B14.329.526e−19133-148PR00113ALKALINE PHOSPHATASE
SIGNATURE
895PR00113C10.885.846e−25180-200PR00113ALKALINE PHOSPHATASE
SIGNATURE
895PR00113D6.876.063e−14239-249PR00113ALKALINE PHOSPHATASE
SIGNATURE
895PR00113E14.042.636e−35330-360PR00113ALKALINE PHOSPHATASE
SIGNATURE
898BL00236D25.666.860e−19 9-50BL00236Neurotransmitter-gated
ion-channels proteins.
898PR00253A9.154.667e−1525-45PR00253GAMMA-AMINOBUTYRIC ACID
(GABA) RECEPTOR
SIGNATURE
898PR00253B13.474.162e−1851-72PR00253GAMMA-AMINOBUTYRIC ACID
(GABA) RECEPTOR
SIGNATURE
898PR00253C13.853.302e−16 85-106PR00253GAMMA-AMINOBUTYRIC ACID
(GABA) RECEPTOR
SIGNATURE
898PR00253D16.681.000e−18228-248PR00253GAMMA-AMINOBUTYRIC ACID
(GABA) RECEPTOR
SIGNATURE
899BL000486.391.000e−081924-1950BL00048Protamine P1 proteins.
899BL000486.391.132e−121873-1899BL00048Protamine P1 proteins.
899BL000486.391.500e−111859-1885BL00048Protamine P1 proteins.
899BL000486.392.303e−101996-2022BL00048Protamine P1 proteins.
899BL000486.392.421e−101870-1896BL00048Protamine P1 proteins.
899BL000486.392.421e−101965-1991BL00048Protamine P1 proteins.
899BL000486.392.421e−101972-1998BL00048Protamine P1 proteins.
899BL000486.392.456e−121858-1884BL00048Protamine P1 proteins.
899BL000486.392.721e−121988-2014BL00048Protamine P1 proteins.
899BL000486.393.000e−111866-1892BL00048Protamine P1 proteins.
899BL000486.393.132e−101850-1876BL00048Protamine P1 proteins.
899BL000486.393.475e−091875-1901BL00048Protamine P1 proteins.
899BL000486.393.487e−101857-1883BL00048Protamine P1 proteins.
899BL000486.393.605e−101935-1961BL00048Protamine P1 proteins.
899BL000486.393.647e−121927-1953BL00048Protamine P1 proteins.
899BL000486.393.813e−091855-1881BL00048Protamine P1 proteins.
899BL000486.393.875e−111960-1986BL00048Protamine P1 proteins.
899BL000486.393.875e−111967-1993BL00048Protamine P1 proteins.
899BL000486.393.875e−111974-2000BL00048Protamine P1 proteins.
899BL000486.394.044e−121871-1897BL00048Protamine P1 proteins.
899BL000486.394.125e−111863-1889BL00048Protamine P1 proteins.
899BL000486.394.323e−131860-1886BL00048Protamine P1 proteins.
899BL000486.394.375e−091941-1967BL00048Protamine P1 proteins.
899BL000486.394.713e−091961-1987BL00048Protamine P1 proteins.
899BL000486.394.713e−091968-1994BL00048Protamine P1 proteins.
899BL000486.394.713e−091975-2001BL00048Protamine P1 proteins.
899BL000486.394.750e−111852-1878BL00048Protamine P1 proteins.
899BL000486.394.838e−121861-1887BL00048Protamine P1 proteins.
899BL000486.395.103e−121989-2015BL00048Protamine P1 proteins.
899BL000486.395.125e−111958-1984BL00048Protamine P1 proteins.
899BL000486.395.500e−101867-1893BL00048Protamine P1 proteins.
899BL000486.395.500e−121874-1900BL00048Protamine P1 proteins.
899BL000486.395.618e−101983-2009BL00048Protamine P1 proteins.
899BL000486.395.632e−121981-2007BL00048Protamine P1 proteins.
899BL000486.395.737e−102025-2051BL00048Protamine P1 proteins.
899BL000486.395.855e−101932-1958BL00048Protamine P1 proteins.
899BL000486.396.123e−131862-1888BL00048Protamine P1 proteins.
899BL000486.396.125e−111869-1895BL00048Protamine P1 proteins.
899BL000486.396.175e−091980-2006BL00048Protamine P1 proteins.
899BL000486.396.294e−121853-1879BL00048Protamine P1 proteins.
899BL000486.396.294e−121865-1891BL00048Protamine P1 proteins.
899BL000486.396.329e−101856-1882BL00048Protamine P1 proteins.
899BL000486.396.375e−111986-2012BL00048Protamine P1 proteins.
899BL000486.396.500e−111979-2005BL00048Protamine P1 proteins.
899BL000486.396.513e−091930-1956BL00048Protamine P1 proteins.
899BL000486.396.566e−101951-1977BL00048Protamine P1 proteins.
899BL000486.396.684e−102026-2052BL00048Protamine P1 proteins.
899BL000486.396.738e−092002-2028BL00048Protamine P1 proteins.
899BL000486.396.850e−091993-2019BL00048Protamine P1 proteins.
899BL000486.396.875e−111868-1894BL00048Protamine P1 proteins.
899BL000486.396.963e−091854-1880BL00048Protamine P1 proteins.
899BL000486.397.221e−121982-2008BL00048Protamine P1 proteins.
899BL000486.397.231e−131926-1952BL00048Protamine P1 proteins.
899BL000486.397.638e−091946-1972BL00048Protamine P1 proteins.
899BL000486.398.200e−091950-1976BL00048Protamine P1 proteins.
899BL000486.398.375e−111990-2016BL00048Protamine P1 proteins.
899BL000486.398.477e−131864-1890BL00048Protamine P1 proteins.
899BL000486.398.500e−111928-1954BL00048Protamine P1 proteins.
899BL000486.398.544e−121872-1898BL00048Protamine P1 proteins.
899BL000486.398.579e−101936-1962BL00048Protamine P1 proteins.
899BL000486.398.625e−112021-2047BL00048Protamine P1 proteins.
899BL000486.398.875e−092030-2056BL00048Protamine P1 proteins.
899BL000486.399.100e−091959-1985BL00048Protamine P1 proteins.
899BL000486.399.100e−091966-1992BL00048Protamine P1 proteins.
899BL000486.399.100e−091973-1999BL00048Protamine P1 proteins.
899BL000486.399.213e−091908-1934BL00048Protamine P1 proteins.
899BL000486.399.289e−101848-1874BL00048Protamine P1 proteins.
899BL000486.399.289e−101925-1951BL00048Protamine P1 proteins.
899BL000486.399.526e−102024-2050BL00048Protamine P1 proteins.
899BL000486.399.603e−121851-1877BL00048Protamine P1 proteins.
899BL000486.399.625e−111953-1979BL00048Protamine P1 proteins.
899BL000486.399.625e−111987-2013BL00048Protamine P1 proteins.
899BL000486.399.763e−101849-1875BL00048Protamine P1 proteins.
899BL000486.399.775e−091997-2023BL00048Protamine P1 proteins.
899BL000486.399.888e−091964-1990BL00048Protamine P1 proteins.
899BL000486.399.888e−091971-1997BL00048Protamine P1 proteins.
899BL000486.399.888e−091978-2004BL00048Protamine P1 proteins.
899BL00348F23.198.169e−10103-145BL00348p53 tumor antigen
proteins.
899BL00970B10.096.736e−091952-1977BL00970Nuclear transition
protein 2 proteins.
899DM0021519.434.706e−111151-1183DM00215PROLINE-RICH PROTEIN 3.
899DM0021519.436.644e−091150-1182DM00215PROLINE-RICH PROTEIN 3.
899DM0021519.438.780e−091154-1186DM00215PROLINE-RICH PROTEIN 3.
899DM00892C23.557.207e−282318-2351DM008923 RETROVIRAL
PROTEINASE.
899DM01206B10.692.139e−091860-1879DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
900BL00284A15.642.565e−1835-58BL00284Serpins proteins.
900BL00284B17.991.621e−13173-193BL00284Serpins proteins.
900BL00284C28.562.038e−29202-243BL00284Serpins proteins.
900BL00284D16.342.241e−17315-341BL00284Serpins proteins.
900BL00284E19.157.158e−21399-423BL00284Serpins proteins.
901BL01160B19.544.203e−09 982-1035BL01160Kinesin light chain
repeat proteins.
901BL01160B19.548.932e−091480-1533BL01160Kinesin light chain
repeat proteins.
901PR00381A9.551.321e−10969-986PR00381KINESIN LIGHT CHAIN
SIGNATURE
901PR00820B3.977.038e−091132-1146PR00820CBXX/CFQX PROTEIN
SIGNATURE
902PR00981A11.624.240e−14336-348PR00981SERYL-TRNA SYNTHETASE
SIGNATURE
902PR00981B11.682.552e−15348-361PR00981SERYL-TRNA SYNTHETASE
SIGNATURE
902PR00981C15.343.919e−12390-403PR00981SERYL-TRNA SYNTHETASE
SIGNATURE
902PR00981D18.101.000e−15407-423PR00981SERYL-TRNA SYNTHETASE
SIGNATURE
902PR00981E13.406.667e−20425-441PR00981SERYL-TRNA SYNTHETASE
SIGNATURE
903BL00509B10.285.000e−09234-244BL00509Ras GTPase-activating
proteins.
903BL01052C18.517.204e−09146-185BL01052Calponin family repeat
proteins.
903BL0115913.855.959e−10650-664BL01159WW/rsp5/WWP domain
proteins.
903PR00403B12.193.593e−09650-664PR00403WW DOMAIN SIGNATURE
904BL00385A11.676.727e−3938-69BL00385Alpha-L-fucosidase
proteins.
904BL00385B24.101.000e−40 79-130BL00385Alpha-L-fucosidase
proteins.
904BL00385C13.731.000e−40132-175BL00385Alpha-L-fucosidase
proteins.
904BL00385D15.937.923e−29176-199BL00385Alpha-L-fucosidase
proteins.
904BL00385E16.211.000e−40213-256BL00385Alpha-L-fucosidase
proteins.
904BL00385F16.091.000e−40257-302BL00385Alpha-L-fucosidase
proteins.
904BL00385G15.692.800e−36321-354BL00385Alpha-L-fucosidase
proteins.
904BL00385H11.867.545e−28355-378BL00385Alpha-L-fucosidase
proteins.
904BL00385I16.171.000e−40388-426BL00385Alpha-L-fucosidase
proteins.
904PR00741A9.249.308e−20 93-108PR00741GLYCOSYL HYDROLASE
FAMILY 29 SIGNATURE
904PR00741B14.231.409e−23132-148PR00741GLYCOSYL HYDROLASE
FAMILY 29 SIGNATURE
904PR00741C9.161.000e−25151-169PR00741GLYCOSYL HYDROLASE
FAMILY 29 SIGNATURE
904PR00741D16.111.621e−25178-197PR00741GLYCOSYL HYDROLASE
FAMILY 29 SIGNATURE
904PR00741E13.392.385e−21218-234PR00741GLYCOSYL HYDROLASE
FAMILY 29 SIGNATURE
904PR00741F14.668.000e−29246-267PR00741GLYCOSYL HYDROLASE
FAMILY 29 SIGNATURE
904PR00741G9.296.870e−26321-342PR00741GLYCOSYL HYDROLASE
FAMILY 29 SIGNATURE
904PR00741H10.321.409e−27354-376PR00741GLYCOSYL HYDROLASE
FAMILY 29 SIGNATURE
905BL00319C17.126.373e−11371-404BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
905BL00319C17.129.171e−09374-407BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
906BL00266A15.696.478e−1241-67BL00266Somatotropin, prolactin
and related hormones
proteins.
907BL00030A14.395.714e−09307-325BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
907BL000486.391.225e−09461-487BL00048Protamine P1 proteins.
907BL000486.391.338e−09452-478BL00048Protamine P1 proteins.
907BL000486.391.829e−10457-483BL00048Protamine P1 proteins.
907BL000486.392.013e−09552-578BL00048Protamine P1 proteins.
907BL000486.392.125e−09474-500BL00048Protamine P1 proteins.
907BL000486.392.191e−12454-480BL00048Protamine P1 proteins.
907BL000486.392.575e−09455-481BL00048Protamine P1 proteins.
907BL000486.392.776e−10450-476BL00048Protamine P1 proteins.
9079L000486.393.842e−10453-479BL00048Protamine P1 proteins.
9079L000486.394.375e−11456-482BL00048Protamine P1 proteins.
907BL000486.394.488e−09460-486BL00048Protamine P1 proteins.
907BL000486.394.500e−11440-466BL00048Protamine P1 proteins.
907BL000486.394.825e−09444-470BL00048Protamine P1 proteins.
907BL000486.395.163e−09555-581BL00048Protamine P1 proteins.
907BL000486.395.382e−10445-471BL00048Protamine P1 proteins.
907BL000486.396.000e−11447-473BL00048Protamine P1 proteins.
907BL000486.396.447e−10448-474BL00048Protamine P1 proteins.
907BL000486.396.625e−09449-475BL00048Protamine P1 proteins.
907BL000486.396.625e−09550-576BL00048Protamine P1 proteins.
907BL000486.396.684e−09458-484BL00048Protamine P1 proteins.
907BL000486.397.300e−09436-462BL00048Protamine P1 proteins.
907BL000486.397.500e−11442-468BL00048Protamine P1 proteins.
907BL000486.397.525e−09551-577BL00048Protamine P1 proteins.
907BL000486.397.868e−10451-477BL00048Protamine P1 proteins.
907BL000486.397.975e−09462-488BL00048Protamine P1 proteins.
907BL000486.397.975e−09476-502BL00048Protamine P1 proteins.
907BL000486.398.000e−11441-467BL00048Protamine P1 proteins.
9072L000486.398.500e−11459-485BL00048Protamine P1 proteins.
907BL000486.398.934e−10438-464BL00048Protamine P1 proteins.
907BL000486.399.053e−10446-472BL00048Protamine P1 proteins.
907BL000486.399.289e−10443-469BL00048Protamine P1 proteins.
907BL000486.399.408e−10439-465BL00048Protamine P1 proteins.
907PF01140D15.546.625e−10559-593PF01140Matrix protein (MA),
p15.
907PF01140D15.546.860e−09435-469PF01140Matrix protein (MA),
p15.
909BL00450D21.149.534e−0933-56BL00450Aconitase family
proteins.
909PR00764F16.899.766e−0951-71PR00764COMPLEMENT C9 SIGNATURE
910BL000486.394.938e−0947-73BL00048Protamine P1 proteins.
911BL00292A22.874.115e−25105-138BL00292Cyclins proteins.
911BL00292B20.318.826e−19148-178BL00292Cyclins proteins.
911PD02331A19.768.990e−11121-167PD02331CYCLIN CELL CYCLE
DIVISION PROTE.
912BL00888B14.791.310e−13308-331BL00888Cyclic nucleotide-
binding domain
proteins.
912BL00888B14.797.600e−19190-213BL00888Cyclic nucleotide-
binding domain
proteins.
912DM01513B6.812.833e−14351-402DM01513CAMP-DEPENDENT PROTEIN
KINASE REGULATORY
CHAIN.
912DM01513B6.819.871e−34227-278DM01513CAMP-DEPENDENT PROTEIN
KINASE REGULATORY
CHAIN.
912PR00103A9.593.483e−13305-319PR00103CAMP-DEPENDENT PROTEIN
KINASE SIGNATURE
912PR00103A9.595.846e−16187-201PR00103CAMP-DEPENDENT PROTEIN
KINASE SIGNATURE
912PR00103B13.395.950e−15202-216PR00103CAMP-DEPENDENT PROTEIN
KINASE SIGNATURE
912PR00103B13.397.300e−11320-334PR00103CAMP-DEPENDENT PROTEIN
KINASE SIGNATURE
912PR00103C15.682.800e−13351-360PR00103CAMP-DEPENDENT PROTEIN
KINASE SIGNATURE
912PR00103D10.832.980e−09239-250PR00103CAMP-DEPENDENT PROTEIN
KINASE SIGNATURE
912PR00103D10.833.700e−14363-374PR00103CAMP-DEPENDENT PROTEIN
KINASE SIGNATURE
912PR00103E17.802.227e−15384-396PR00103CAMP-DEPENDENT PROTEIN
KINASE SIGNATURE
913BL01154A18.703.000e−2257-77BL01154RNA polymerases L/13
to 16 Kd subunits
proteins.
913BL01154B24.555.500e−36 78-113BL01154RNA polymerases L/13
to 16 Kd subunits
proteins.
914BL000486.399.100e−091321-1347BL00048Protamine P1 proteins.
914BL000486.399.663e−091322-1348BL00048Protamine P1 proteins.
914BL00291A4.496.690e−09894-928BL00291Prion protein.
914BL00415C7.093.182e−09450-479BL00415Synapsins proteins.
914BL00420A20.422.938e−09856-884BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.423.361e−10763-791BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.423.400e−141482-1510BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.423.782e−11617-645BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.424.246e−10808-836BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.424.836e−101485-1513BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.425.500e−12614-642BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.426.236e−11679-707BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.426.400e−09859-887BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.426.677e−09802-830BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.427.709e−11620-648BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.427.923e−09641-669BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.428.672e−10796-824BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.429.018e−11644-672BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.429.031e−09694-722BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.429.705e−10938-966BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.429.827e−12721-749BL00420Speract receptor repeat
proteins domain
proteins.
914BL00420A20.429.836e−11697-725BL00420Speract receptor repeat
proteins domain
proteins.
914BL01113A17.991.000e−08805-831BL01113C1q domain proteins.
914BL01113A17.991.000e−13802-828BL01113C1q domain proteins.
914BL01113A17.991.173e−09814-840BL01113C1q domain proteins.
914BL01113A17.991.346e−091028-1054BL01113C1q domain proteins.
914BL01113A17.991.383e−101244-1270BL01113C1q domain proteins.
914BL01113A17.991.462e−121473-1499BL01113C1q domain proteins.
914BL01113A17.991.766e−10685-711BL01113C1q domain proteins.
914BL01113A17.992.023e−11617-643BL01113C1q domain proteins.
914BL01113A17.992.038e−09817-843BL01113C1q domain proteins.
914BL01113A17.992.212e−09793-819BL01113C1q domain proteins.
914BL01113A17.992.227e−11947-973BL01113C1q domain proteins.
914BL01113A17.992.385e−09632-658BL01113C1q domain proteins.
914BL01113A17.992.385e−121491-1517BL01113C1q domain proteins.
914BL01113A17.992.432e−11859-885BL01113C1q domain proteins.
914BL01113A17.992.558e−09620-646BL01113C1q domain proteins.
914BL01113A17.992.731e−09682-708BL01113C1q domain proteins.
914BL01113A17.992.731e−09897-923BL01113C1q domain proteins.
914BL01113A17.993.489e−101488-1514BL01113C1q domain proteins.
914BL01113A17.993.769e−17856-882BL01113C1q domain proteins.
914BL01113A17.994.068e−11941-967BL01113C1q domain proteins.
914BL01113A17.994.288e−09676-702BL01113C1q domain proteins.
914BL01113A17.994.447e−10862-888BL01113C1q domain proteins.
914BL01113A17.994.462e−091213-1239BL01113C1q domain proteins.
914BL01113A17.994.462e−09 989-1015BL01113C1q domain proteins.
914BL01113A17.994.638e−10811-837BL01113C1q domain proteins.
914BL01113A17.994.981e−09748-774BL01113C1q domain proteins.
914BL01113A17.995.213e−10697-723BL01113C1q domain proteins.
914BL01113A17.995.500e−09611-637BL01113C1q domain proteins.
914BL01113A17.995.500e−11727-753BL01113C1q domain proteins.
914BL01113A17.995.846e−09826-852BL01113C1q domain proteins.
914BL01113A17.995.909e−11944-970BL01113C1q domain proteins.
914BL01113A17.996.365e−091181-1207BL01113C1q domain proteins.
914BL01113A17.996.365e−09614-640BL01113C1q domain proteins.
914BL01113A17.997.128e−10938-964BL01113C1q domain proteins.
914BL01113A17.997.404e−09820-846BL01113C1q domain proteins.
914BL01113A17.997.404e−09850-876BL01113C1q domain proteins.
914BL01113A17.997.511e−101497-1523BL01113C1q domain proteins.
914BL01113A17.997.577e−091253-1279BL01113C1q domain proteins.
914BL01113A17.997.702e−10799-825BL01113C1q domain proteins.
914BL01113A17.997.818e−14623-649BL01113C1q domain proteins.
914BL01113A17.997.955e−111485-1511BL01113C1q domain proteins.
914BL01113A17.997.955e−11796-822BL01113C1q domain proteins.
914BL01113A17.998.096e−09871-897BL01113C1q domain proteins.
914BL01113A17.998.159e−11808-834BL01113C1q domain proteins.
914BL01113A17.998.364e−11626-652BL01113C1q domain proteins.
914BL01113A17.998.468e−10865-891BL01113C1q domain proteins.
914BL01113A17.998.541e−131247-1273BL01113C1q domain proteins.
914BL01113A17.998.962e−091494-1520BL01113C1q domain proteins.
914BL01113A17.998.962e−09691-717BL01113C1q domain proteins.
914BL01113A17.999.308e−09703-729BL01113C1q domain proteins.
914BL01113A17.999.386e−111482-1508BL01113C1q domain proteins.
914BL01113A17.999.426e−10706-732BL01113C1q domain proteins.
914BL01113A17.999.591e−11853-879BL01113C1q domain proteins.
914BL01113A17.999.617e−10911-937BL01113C1q domain proteins.
914BL01113A17.999.654e−09736-762BL01113C1q domain proteins.
914BL01113A17.999.727e−14 986-1012BL01113C1q domain proteins.
914BL01113A17.999.757e−13602-628BL01113C1q domain proteins.
914BL01113A17.999.809e−10739-765BL01113C1q domain proteins.
914PR00049D0.006.339e−091490-1504PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
914PR00049D0.008.322e−09856-870PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
914PR00524F5.363.394e−09906-919PR00524CHOLECYSTOKININ TYPE A
RECEPTOR SIGNATURE
914PR00524F5.365.552e−101497-1510PR00524CHOLECYSTOKININ TYPE A
RECEPTOR SIGNATURE
916BL00022B7.541.000e−092640-2646BL00022EGF-like domain
proteins.
916BL00022B7.541.000e−09444-450BL00022EGF-like domain
proteins.
916BL00022B7.541.900e−092129-2135BL00022EGF-like domain
proteins.
916BL00243H17.534.682e−12253-278BL00243Integrins beta chain
cysteine-rich domain
proteins.
916BL01177C17.393.000e−09629-647BL01177Anaphylatoxin domain
proteins.
916BL01177D17.503.000e−092097-2114BL01177Anaphylatoxin domain
proteins.
916BL01177D17.509.333e−091321-1338BL01177Anaphylatoxin domain
proteins.
916BL01187A9.982.125e−09742-753BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.982.286e−101575-1586BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.982.286e−102059-2070BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.982.875e−09375-386BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.982.895e−111367-1378BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.983.455e−14936-947BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.983.571e−101492-1503BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.984.000e−092142-2153BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.984.000e−101039-1050BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.984.316e−111937-1948BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.984.375e−12619-630BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.984.750e−091451-1462BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.985.125e−091409-1420BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.985.286e−10417-428BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.985.500e−091616-1627BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.985.714e−102335-2346BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.985.875e−091242-1253BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.986.250e−092020-2031BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.986.625e−09659-670BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.987.000e−091284-1295BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.987.750e−091777-1788BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.988.125e−092295-2306BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.989.143e−101199-1210BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187A9.989.250e−092614-2625BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.041.257e−101592-1607BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.041.300e−11393-408BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.041.391e−13435-450BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.041.450e−141511-1526BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.041.667e−121913-1928BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.042.000e−12596-611BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.042.059e−152273-2288BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.042.059e−152631-2646BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.042.565e−131427-1442BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.042.957e−132160-2175BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.042.957e−132672-2687BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.043.077e−162590-2605BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.043.348e−13912-927BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.043.700e−141633-1648BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.044.130e−131753-1768BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.044.150e−141955-1970BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.044.176e−152352-2367BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.044.300e−11870-885BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.044.333e−12759-774BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.044.522e−131343-1358BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.044.667e−121217-1232BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.045.050e−142438-2453BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.045.235e−15635-650BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.045.667e−121794-1809BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.046.087e−131470-1485BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.046.100e−111057-1072BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.046.400e−142712-2727BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.046.667e−121996-2011BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.046.824e−152120-2135BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.046.870e−132549-2564BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.047.333e−122312-2327BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.047.686e−101385-1400BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.047.750e−142078-2093BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.047.750e−142794-2809BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.048.000e−121302-1317BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.048.500e−172753-2768BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.048.650e−14677-692BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.048.667e−122396-2411BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.048.826e−131175-1190BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.048.826e−132036-2051BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.048.826e−13718-733BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.049.550e−141260-1275BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916BL01187B12.049.609e−131551-1566BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
916DM0021519.431.000e−09530-562DM00215PROLINE-RICH PROTEIN 3.
916DM0021519.436.063e−12545-577DM00215PROLINE-RICH PROTEIN 3.
916DM00864B11.344.896e−101960-1978DM00864EGF-LIKE DOMAIN.
916DM00864B11.346.577e−092799-2817DM00864EGF-LIKE DOMAIN.
916DM00864B11.347.179e−10601-619DM00864EGF-LIKE DOMAIN.
916DM00864B11.348.732e−091556-1574DM00864EGF-LIKE DOMAIN.
916PR00010A11.794.115e−11938-949PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.161.000e−10640-650PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.161.214e−092443-2453PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.162.286e−092758-2768PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.162.667e−111348-1358PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.163.357e−091918-1928PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.163.455e−102125-2135PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.163.571e−092165-2175PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.164.429e−092717-2727PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.164.818e−102357-2367PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.165.333e−11917-927PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.165.364e−10440-450PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.165.500e−092317-2327PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.166.182e−102677-2687PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.166.357e−091638-1648PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.167.000e−112636-2646PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.167.545e−102595-2605PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.169.143e−091265-1275PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.169.727e−102278-2288PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00010C11.169.727e−102799-2809PR00010TYPE II EGF-LIKE
SIGNATURE
916PR00907B11.291.000e−082790-2806PR00907THROMBOMODULIN
SIGNATURE
916PR00907B11.292.756e−092627-2643PR00907THROMBOMODULIN
SIGNATURE
916PR00907B11.295.957e−122708-2724PR00907THROMBOMODULIN
SIGNATURE
916PR00907B11.297.805e−092586-2602PR00907THROMBOMODULIN
SIGNATURE
916PR00907D5.598.609e−092278-2303PR00907THROMBOMODULIN
SIGNATURE
916PR00907G11.632.135e−091592-1618PR00907THROMBOMODULIN
SIGNATURE
916PR00907G11.633.189e−091633-1659PR00907THROMBOMODULIN
SIGNATURE
916PR00907G11.633.189e−092273-2299PR00907THROMBOMODULIN
SIGNATURE
916PR00907G11.633.673e−111260-1286PR00907THROMBOMODULIN
SIGNATURE
916PR00907G11.635.546e−122120-2146PR00907THROMBOMODULIN
SIGNATURE
916PR00907G11.636.514e−09718-744PR00907THROMBOMODULIN
SIGNATURE
916PR00907G11.638.378e−091470-1496PR00907THROMBOMODULIN
SIGNATURE
916PR00907G11.639.321e−102396-2422PR00907THROMBOMODULIN
SIGNATURE
916PR00907G11.639.406e−101343-1369PR00907THROMBOMODULIN
SIGNATURE
917BL0002324.312.969e−28332-368BL00023Type II fibronectin
collagen-binding domain
proteins.
917BL0002324.314.682e−35390-426BL00023Type II fibronectin
collagen-binding domain
proteins.
917BL0002324.319.526e−24274-310BL00023Type II fibronectin
collagen-binding domain
proteins.
917BL00024A11.492.800e−13145-155BL00024Hemopexin domain
proteins.
917BL00024B21.539.591e−33166-199BL00024Hemopexin domain
proteins.
917BL00024C22.981.000e−40214-262BL00024Hemopexin domain
proteins.
917BL00024D17.283.571e−35442-473BL00024Hemopexin domain
proteins.
917BL00024E7.586.625e−16481-494BL00024Hemopexin domain
proteins.
917BL00024F11.302.038e−22523-543BL00024Hemopexin domain
proteins.
917BL00024G13.317.158e−14561-573BL00024Hemopexin domain
proteins.
917BL00024H11.351.794e−11581-592BL00024Hemopexin domain
proteins.
917BL00024H11.354.600e−09629-640BL00024Hemopexin domain
proteins.
917BL001428.386.000e−12448-458BL00142Neutral zinc
metallopeptidases,
zinc-binding region
proteins.
917BL00546A19.628.105e−30125-154BL00546Matrixins cysteine
switch.
917BL00546B20.111.000e−40215-258BL00546Matrixins cysteine
switch.
917BL00546C16.415.714e−35442-473BL00546Matrixins cysteine
switch.
917BL00546D10.344.000e−16481-494BL00546Matrixins cysteine
switch.
917BL00546E10.238.269e−23523-543BL00546Matrixins cysteine
switch.
917BL00546F12.407.955e−14561-573BL00546Matrixins cysteine
switch.
917BL00546G16.848.269e−17582-601BL00546Matrixins cysteine
switch.
917BL00546H10.761.257e−10678-688BL00546Matrixins cysteine
switch.
917BL00546H10.764.073e−09629-639BL00546Matrixins cysteine
switch.
917PR00013A12.265.333e−09336-345PR00013FIBRONECTIN TYPE II
REPEAT SIGNATURE
917PR00013A12.265.500e−13394-403PR00013FIBRONECTIN TYPE II
REPEAT SIGNATURE
917PR00013A12.267.833e−09278-287PR00013FIBRONECTIN TYPE II
REPEAT SIGNATURE
917PR00013B14.751.237e−11405-417PR00013FIBRONECTIN TYPE II
REPEAT SIGNATURE
917PR00013B14.754.000e−09347-359PR00013FIBRONECTIN TYPE II
REPEAT SIGNATURE
917PR00013C12.291.000e−20422-437PR00013FIBRONECTIN TYPE II
REPEAT SIGNATURE
917PR00013C12.293.571e−15364-379PR00013FIBRONECTIN TYPE II
REPEAT SIGNATURE
917PR00013C12.297.800e−14306-321PR00013FIBRONECTIN TYPE II
REPEAT SIGNATURE
917PR00138A15.148.773e−16145-158PR00138MATRIXIN SIGNATURE
917PR00138B15.825.500e−18192-207PR00138MATRIXIN SIGNATURE
917PR00138C16.411.783e−32215-243PR00138MATRIXIN SIGNATURE
917PR00138D16.568.920e−28448-473PR00138MATRIXIN SIGNATURE
917PR00138E6.015.000e−16481-494PR00138MATRIXIN SIGNATURE
917PR00480B15.412.286e−09443-461PR00480ASTACIN FAMILY
SIGNATURE
918PF01130B21.401.537e−15223-268PF01130CD36 family.
918PF01130C22.911.851e−18278-327PF01130CD36 family.
918PF01130D26.651.955e−23360-413PF01130CD36 family.
920BL01289A12.188.200e−33141-167BL01289TSC-22/dip/bun
family proteins.
920BL01289B10.458.071e−30168-197BL01289TSC-22/dip/bun
family proteins.
920DM00475B12.125.891e−10162-181DM00475w LOW TRANSPOSASE SAPA
12K.
921PD01719A12.892.111e−09416-443PD01719PRECURSOR GLYCOPROTEIN
SIGNAL RE.
921PR00711D7.919.697e−09255-272PR00711ATRIAL NATRIURETIC
PEPTIDE SIGNATURE
923BL00139A10.296.478e−14107-116BL00139Eukaryotic thiol
(cysteine) proteases
cysteine proteins.
923BL00139B10.196.400e−10152-160BL00139Eukaryotic thiol
(cysteine) proteases
cysteine proteins.
923BL00139D9.249.182e−18298-314BL00139Eukaryotic thiol
(cysteine) proteases
cysteine proteins.
923PR00705A10.551.529e−16107-122PR00705PAPAIN CYSTEINE
PROTEASE (C1) FAMILY
SIGNATURE
923PR00705B10.224.115e−10283-293PR00705PAPAIN CYSTEINE
PROTEASE (C1) FAMILY
SIGNATURE
925PF01140D15.546.547e−09176-210PF01140Matrix protein (MA),
p15.
926BL00755A13.964.750e−1450-68BL00755Protein secY proteins.
926BL00755B12.127.469e−18 87-106BL00755Protein secY proteins.
926BL00755C14.216.885e−13203-218BL00755Protein secY proteins.
926BL00755D11.884.214e−17291-309BL00755Protein secY proteins.
926BL00755E26.661.923e−26385-425BL00755Protein secY proteins.
926PR00303B10.179.769e−09 86-106PR00303PREPROTEIN TRANSLOCASE
SECY SUBUNIT SIGNATURE
928BL01019A13.201.000e−40 69-108BL01019ADP-ribosylation
factors family
proteins.
928BL01019B19.491.000e−40113-167BL01019ADP-ribosylation
factors family
proteins.
928BL01019C12.523.842e−26170-195BL01019ADP-ribosylation
factors family
proteins.
928BL01020C15.358.200e−15 97-147BL01020SAR1 family proteins.
928PR00328A10.625.213e−1141-64PR00328GTP-BINDING SAR1
PROTEIN SIGNATURE
928PR00328C13.162.444e−12 96-121PR00328GTP-BINDING SAR1
PROTEIN SIGNATURE
930BL00824A13.788.650e−1455-69BL00824Elongation factor 1
beta/beta′/delta chain
proteins.
930BL00824B9.212.080e−21132-151BL00824Elongation factor 1
beta/beta′/delta chain
proteins.
930BL00824C14.581.000e−40165-202BL00824Elongation factor 1
beta/beta′/delta chain
proteins.
930BL00824D14.046.192e−39203-237BL00824Elongation factor 1
beta/beta′/delta chain
proteins.
930BL00824E12.493.333e−19246-261BL00824Elongation factor 1
beta/beta′/delta chain
proteins.
931BL00291A4.499.192e−11140-174BL00291Prion protein.
931PD01234B15.535.179e−09227-244PD01234PROTEIN NUCLEAR
BROMODOMAIN TRANS.
931PR00049D0.007.504e−1185-99PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
931PR00049D0.009.214e−10270-284PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
931PR00910A2.519.571e−09272-284PR00910LUTEOVIRUS ORF6 PROTEIN
SIGNATURE
933BL00415O3.443.368e−09289-326BL00415Synapsins proteins.
933BL01088A7.264.000e−1716-30BL01088CAP protein.
933BL01088B15.911.000e−40150-191BL01088CAP protein.
933BL01088C9.976.684e−26194-216BL01088CAP protein.
933BL01088D14.324.130e−36264-296BL01088CAP protein.
933BL01088E15.831.375e−28326-353BL01088CAP protein.
933BL01088F14.831.000e−40358-403BL01088CAP protein.
933BL01088G12.701.000e−40408-451BL01088CAP protein.
933BL01088H12.107.353e−24453-472BL01088CAP protein.
933PR00049D0.006.143e−11235-249PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
933PR00049D0.008.714e−11236-250PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
933PR00049D0.008.714e−11237-251PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
933PR00049D0.008.790e−11238-252PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
934BL00237A27.688.875e−27228-267BL00237G-protein coupled
receptors proteins.
934BL00237B5.289.438e−11339-350BL00237G-protein coupled
receptors proteins.
934BL00237C13.193.172e−12366-392BL00237G-protein coupled
receptors proteins.
934BL00237D11.239.308e−11423-439BL00237G-protein coupled
receptors proteins.
934PR00237A11.488.714e−12164-188PR00237RHODOPSIN-LIKE GPCR
SUPERFAMILY SIGNATURE
934PR00237B13.504.724e−11197-218PR00237RHODOPSIN-LIKE GPCR
SUPERFAMILY SIGNATURE
934PR00237C15.698.800e−18242-264PR00237RHODOPSIN-LIKE GPCR
SUPERFAMILY SIGNATURE
934PR00237D8.948.875e−10278-299PR00237RHODOPSIN-LIKE GPCR
SUPERFAMILY SIGNATURE
934PR00237E13.037.000e−11331-354PR00237RHODOPSIN-LIKE GPCR
SUPERFAMILY SIGNATURE
934PR00237F13.576.516e−11371-395PR00237RHODOPSIN-LIKE GPCR
SUPERFAMILY SIGNATURE
934PR00237G19.631.621e−13413-439PR00237RHODOPSIN-LIKE GPCR
SUPERFAMILY SIGNATURE
934PR00425C13.233.036e−10228-247PR00425BRADYKININ RECEPTOR
SIGNATURE
934PR00571E19.502.333e−09227-238PR00571ENDOTHELIN-B RECEPTOR
SIGNATURE
934PR00908A7.785.909e−1965-81PR00908THROMBIN RECEPTOR
SIGNATURE
934PR00908B16.822.029e−20148-164PR00908THROMBIN RECEPTOR
SIGNATURE
934PR00908C9.931.310e−19190-203PR00908THROMBIN RECEPTOR
SIGNATURE
934PR00908D11.104.429e−19269-283PR00908THROMBIN RECEPTOR
SIGNATURE
934PR00908E3.451.000e−17326-339PR00908THROMBIN RECEPTOR
SIGNATURE
934PR00908F8.011.000e−23355-373PR00908THROMBIN RECEPTOR
SIGNATURE
934PR00908G13.245.865e−24438-456PR00908THROMBIN RECEPTOR
SIGNATURE
934PR00908H11.641.450e−23467-484PR00908THROMBIN RECEPTOR
SIGNATURE
935BL000187.411.000e−0979-91BL00018EF-hand calcium-binding
domain proteins.
935BL000187.413.400e−12152-164BL00018EF-hand calcium-binding
domain proteins.
935BL00303B26.156.344e−10 67-103BL00303S-100/ICaBP type
calcium binding
protein.
935PR00450C12.224.480e−10111-132PR00450RECOVERIN FAMILY
SIGNATURE
935PR00450C12.225.320e−1038-59PR00450RECOVERIN FAMILY
SIGNATURE
935PR00450C12.226.520e−1074-95PR00450RECOVERIN FAMILY
SIGNATURE
936BL00030A14.394.500e−10107-125BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
936BL00030B7.031.474e−09146-155BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
940PR00401B12.943.667e−09129-139PR00401SH2 DOMAIN SIGNATURE
943BL01052A16.127.618e−3235-66BL01052Calponin family repeat
proteins.
943BL01052B15.318.031e−26 84-109BL01052Calponin family repeat
proteins.
943BL01052C18.516.806e−40119-158BL01052Calponin family repeat
proteins.
943BL01052D10.261.000e−24206-225BL01052Calponin family repeat
proteins.
943PR00888A11.872.350e−1635-49PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
943PR00888B13.722.350e−1254-67PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
943PR00888C12.275.179e−1884-99PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
943PR00888D16.094.273e−17120-136PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
943PR00888E11.813.432e−16136-151PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
943PR00888F7.444.825e−14157-171PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
943PR00888G12.738.759e−14194-207PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
943PR00888H9.975.154e−20207-222PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
943PR00889E12.182.726e−12203-218PR00889CALPONIN SIGNATURE
943PR00890A8.619.775e−2166-85PR00890SMOOTH MUSCLE PROTEIN
22-ALPHA (TRANSGELIN)
SIGNATURE
943PR00890B8.753.455e−17 94-109PR00890SMOOTH MUSCLE PROTEIN
22-ALPHA (TRANSGELIN)
SIGNATURE
943PR00890C8.221.000e−17116-129PR00890SMOOTH MUSCLE PROTEIN
22-ALPHA (TRANSGELIN)
SIGNATURE
943PR00890D16.175.174e−13150-159PR00890SMOOTH MUSCLE PROTEIN
22-ALPHA (TRANSGELIN)
SIGNATURE
943PR00890E14.343.813e−21167-186PR00890SMOOTH MUSCLE PROTEIN
22-ALPHA (TRANSGELIN)
SIGNATURE
943PR00890F12.924.064e−14193-205PR00890SMOOTH MUSCLE PROTEIN
22-ALPHA (TRANSGELIN)
SIGNATURE
947BL00415N4.292.248e−09276-319BL00415Synapsins proteins.
950BL01031C17.686.400e−10125-149BL01031Heat shock hsp20
proteins family
profile.
950PR00299D8.566.318e−09115-128PR00299ALPHA CRYSTALLIN
SIGNATURE
950PR00299F13.202.139e−09152-173PR00299ALPHA CRYSTALLIN
SIGNATURE
951BL00019A12.564.789e−1556-66BL00019Actinin-type actin-
binding domain
proteins.
951BL00019B13.349.250e−23 81-103BL00019Actinin-type actin-
binding domain
proteins.
951BL00019C14.667.300e−37127-162BL00019Actinin-type actin-
binding domain
proteins.
951BL00019D15.337.000e−33186-215BL00019Actinin-type actin-
binding domain
proteins.
951BL00019E15.914.000e−13341-350BL00019Actinin-type actin-
binding domain
proteins.
951BL00019F19.686.464e−19392-413BL00019Actinin-type actin-
binding domain
proteins.
951BL00303B26.158.172e−10815-851BL00303S-100/ICaBP type
calcium binding
protein.
951PF00435A32.052.421e−19243-271PF00435Spectrin repeat
proteins.
951PF00435B13.412.174e−11508-523PF00435Spectrin repeat
proteins.
951PF00435C20.739.036e−09526-545PF00435Spectrin repeat
proteins.
952PR00111A11.494.150e−12171-186PR00111ALPHA/BETA HYDROLASE
FOLD SIGNATURE
952PR00412A13.236.400e−11151-169PR00412EPOXIDE HYDROLASE
SIGNATURE
952PR00412B12.592.929e−10171-186PR00412EPOXIDE HYDROLASE
SIGNATURE
954BL01221A17.267.750e−2012-39BL01221PMP-22/EMP/MP20
family proteins.
954BL01221B13.296.182e−1246-59BL01221PMP-22/EMP/MP20
family proteins.
954BL01221C26.208.159e−26 69-113BL01221PMP-22/EMP/MP20
family proteins.
954BL01221C26.209.100e−28 72-116BL01221PMP-22/EMP/MP20
family proteins.
955PF00783A11.914.214e−13577-586PF00783Inositol polyphosphate
phosphatase, catalytic
domain proteins
homologu.
955PF00783B10.542.552e−10658-667PF00783Inositol polyphosphate
phosphatase, catalytic
domain proteins
homologu.
955PR00049D0.003.071e−101019-1033PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
955PR00049D0.007.407e−091060-1074PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
956BL00030B7.033.368e−0983-92BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
956BL000486.391.415e−13157-183BL00048Protamine P1 proteins.
956BL000486.391.750e−11151-177BL00048Protamine P1 proteins.
956BL000486.391.750e−11240-266BL00048Protamine P1 proteins.
956BL000486.392.184e−10190-216BL00048Protamine P1 proteins.
956BL000486.392.421e−10198-224BL00048Protamine P1 proteins.
956BL000486.392.588e−12173-199BL00048Protamine P1 proteins.
956BL000486.392.800e−09188-214BL00048Protamine P1 proteins.
956BL000486.392.895e−10184-210BL00048Protamine P1 proteins.
956BL000486.393.077e−13160-186BL00048Protamine P1 proteins.
956BL000486.393.813e−09227-253BL00048Protamine P1 proteins.
956BL000486.393.912e−12175-201BL00048Protamine P1 proteins.
956BL000486.393.925e−09186-212BL00048Protamine P1 proteins.
956BL000486.394.246e−14166-192BL00048Protamine P1 proteins.
956BL000486.394.316e−10152-178BL00048Protamine P1 proteins.
956BL000486.394.713e−09153-179BL00048Protamine P1 proteins.
956BL000486.395.375e−11182-208BL00048Protamine P1 proteins.
956BL000486.395.585e−17163-189BL00048Protamine P1 proteins.
956BL000486.395.708e−13162-188BL00048Protamine P1 proteins.
956BL000486.396.063e−09176-202BL00048Protamine P1 proteins.
956BL000486.396.143e−16161-187BL00048Protamine P1 proteins.
956BL000486.396.288e−09189-215BL00048Protamine P1 proteins.
956BL000486.396.311e−14158-184BL00048Protamine P1 proteins.
956BL000486.396.803e−10223-249BL00048Protamine P1 proteins.
956BL000486.397.188e−09225-251BL00048Protamine P1 proteins.
956BL000486.397.413e−09183-209BL00048Protamine P1 proteins.
956BL000486.397.618e−12156-182BL00048Protamine P1 proteins.
956BL000486.397.632e−10180-206BL00048Protamine P1 proteins.
956BL000486.397.639e−14165-191BL00048Protamine P1 proteins.
956BL000486.398.000e−11164-190BL00048Protamine P1 proteins.
956BL000486.398.000e−11177-203BL00048Protamine P1 proteins.
956BL000486.398.015e−12167-193BL00048Protamine P1 proteins.
956BL000486.398.088e−09170-196BL00048Protamine P1 proteins.
956BL000486.398.105e−10154-180BL00048Protamine P1 proteins.
956BL000486.398.302e−17159-185BL00048Protamine P1 proteins.
956BL000486.398.375e−11169-195BL00048Protamine P1 proteins.
956BL000486.398.377e−14174-200BL00048Protamine P1 proteins.
956BL000486.398.425e−09168-194BL00048Protamine P1 proteins.
956BL000486.398.625e−11181-207BL00048Protamine P1 proteins.
956BL000486.399.100e−09232-258BL00048Protamine P1 proteins.
956BL000486.399.375e−11194-220BL00048Protamine P1 proteins.
956BL000486.399.625e−11155-181BL00048Protamine P1 proteins.
956BL000486.399.735e−12172-198BL00048Protamine P1 proteins.
956BL000486.399.875e−11171-197BL00048Protamine P1 proteins.
956BL000486.399.882e−10192-218BL00048Protamine P1 proteins.
956DM01206B10.691.570e−09169-188DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
956DM01206B10.694.452e−10163-182DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
956DM01206B10.694.532e−09157-176DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
956DM01206B10.694.532e−09223-242DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
956DM01206B10.695.899e−09155-174DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
956DM01206B10.697.411e−10159-178DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
956PD02784B26.469.745e−09 79-121PD02784PROTEIN NUCLEAR
RIBONUCLEOPROTEIN.
957BL01160B19.545.653e−09253-306BL01160Kinesin light chain
repeat proteins.
957BL01160B19.545.710e−11260-313BL01160Kinesin light chain
repeat proteins.
958PR00049D0.006.445e−11430-444PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
959BL00250A21.247.000e−35340-375BL00250TGF-beta family
proteins.
959BL00250B27.378.071e−32409-444BL00250TGF-beta family
proteins.
959PR00438A13.547.300e−11365-374PR00438GROWTH FACTOR CYSTINE
KNOT SUPERFAMILY
SIGNATURE
959PR00669F5.579.494e−09357-374PR00669INHIBIN ALPHA CHAIN
SIGNATURE
959PR00670A11.241.750e−2421-38PR00670INHIBIN BETA A CHAIN
SIGNATURE
959PR00670B13.061.360e−2838-59PR00670INHIBIN BETA A CHAIN
SIGNATURE
959PR00670C11.983.250e−1983-96PR00670INHIBIN BETA A CHAIN
SIGNATURE
959PR00670D13.391.231e−22123-139PR00670INHIBIN BETA A CHAIN
SIGNATURE
959PR00670E3.631.333e−25268-289PR00670INHIBIN BETA A CHAIN
SIGNATURE
959PR00670F10.104.818e−13298-308PR00670INHIBIN BETA A CHAIN
SIGNATURE
960BL00154C12.386.580e−1279-97BL00154E1-E2 ATPases
phosphorylation site
proteins.
960BL00154E20.379.820e−15347-387BL00154E1-E2 ATPases
phosphorylation site
proteins.
960BL00154F8.238.859e−10502-525BL00154E1-E2 ATPases
phosphorylation site
proteins.
960BL00592E12.539.100e−09168-184BL00592Glycosyl hydrolases
family 9 proteins.
960BL01228D17.447.150e−11503-527BL01228Hypothetical cof family
proteins.
960PR00119B13.946.694e−1283-97PR00119P-TYPE CATION-
TRANSPORTING ATPASE
SUPERFAMILY SIGNATURE
960PR00119D9.562.432e−09363-373PR00119P-TYPE CATION-
TRANSPORTING ATPASE
SUPERFAMILY SIGNATURE
960PR00121D16.724.621e−1176-97PR00121SODIUM/POTASSIUM-
TRANSPORTING ATPASE
SIGNATURE
961BL00030A14.395.765e−1114-32BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
961BL00030A14.396.571e−09297-315BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
961BL00030B7.034.316e−09334-343BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
961BL00030B7.036.400e−10232-241BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
961BL00030B7.038.579e−09139-148BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
961PD02784A21.094.583e−09 94-130PD02784PROTEIN NUCLEAR
RIBONUCLEOPROTEIN.
961PD02784B26.464.651e−0949-91PD02784PROTEIN NUCLEAR
RIBONUCLEOPROTEIN.
961PF00658A19.881.000e−40 84-123PF00658Poly-adenylate binding
protein, unique domain
proteins.
961PF00658B28.571.000e−40263-309PF00658Poly-adenylate binding
protein, unique domain
proteins.
961PF00658C16.338.500e−36579-615PF00658Poly-adenylate binding
protein, unique domain
proteins.
962BL000369.025.737e−11682-694BL00036bZIP transcription
factors basic domain
proteins.
962PF00624I9.104.331e−09507-536PF00624Flocculin repeat
proteins.
962PF00624I9.105.125e−10510-539PF00624Flocculin repeat
proteins.
962PF00624I9.105.800e−10511-540PF00624Flocculin repeat
proteins.
962PF00624I9.106.457e−09505-534PF00624Flocculin repeat
proteins.
962PF00624I9.106.811e−09502-531PF00624Flocculin repeat
proteins.
962PF00624I9.108.441e−09503-532PF00624Flocculin repeat
proteins.
962PR00043B8.739.241e−11682-698PR00043JUN TRANSCRIPTION
FACTOR SIGNATURE
963BL01160B19.549.676e−10308-361BL01160Kinesin light chain
repeat proteins.
964BL00291A4.491.000e−09540-574BL00291Prion protein.
964BL00415N4.298.095e−09347-390BL00415Synapsins proteins.
964BL00420A20.421.000e−12345-373BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.421.148e−10810-838BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.421.295e−10873-901BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.421.590e−10840-868BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.421.692e−09438-466BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.421.738e−10459-487BL00420Speract receptor repeat
proteins domain
964BL00420A20.421.885e−10207-235BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.421.969e−09204-232BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.422.108e−09198-226BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.422.108e−09747-775BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.422.108e−09867-895BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.422.246e−09216-244BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.422.246e−09669-697BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.422.523e−09642-670BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.422.800e−09219-247BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.422.800e−09516-544BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.422.800e−09564-592BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.423.066e−10798-826BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.423.077e−09687-715BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.423.213e−10552-580BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.423.215e−09330-358BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.423.354e−09588-616BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.423.361e−10627-655BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.423.492e−09240-268BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.423.508e−10327-355BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.423.618e−11807-835BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.423.631e−09106-134BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.423.631e−09339-367BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.424.098e−10366-394BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.424.098e−10675-703BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.424.185e−09348-376BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.424.185e−09486-514BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.424.185e−09756-784BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.424.306e−13720-748BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.424.689e−10480-508BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.424.689e−10570-598BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.424.836e−10195-223BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.424.927e−11705-733BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.425.015e−09189-217BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.425.091e−11180-208BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.425.154e−09861-889BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.425.426e−10774-802BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.425.600e−14408-436BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.425.708e−09372-400BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.425.721e−10651-679BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.425.776e−13426-454BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.425.846e−09300-328BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.425.869e−10109-137BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.016e−10537-565BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.073e−11801-829BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.123e−09546-574BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.123e−09603-631BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.164e−10306-334BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.164e−10483-511BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.164e−10549-577BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.164e−10777-805BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.262e−09183-211BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.262e−09837-865BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.400e−09741-769BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.400e−11843-871BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.607e−10186-214BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.754e−10423-451BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.426.815e−09753-781BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.427.049e−10318-346BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.427.092e−09789-817BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.427.231e−09471-499BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.427.344e−10390-418BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.427.923e−09243-271BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.427.923e−09261-289BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.427.923e−12417-445BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.428.082e−10813-841BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.428.200e−11282-310BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.428.230e−10771-799BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.428.338e−09420-448BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.428.615e−09513-541BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.428.754e−09525-553BL00420Speract receptor repeat
proteins domain
964BL00420A20.428.892e−09681-709BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.428.898e−13534-562BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.429.262e−10249-277BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.429.262e−10576-604BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.429.308e−09201-229BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.429.446e−09717-745BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.429.557e−10297-325BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.429.585e−09165-193BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.429.705e−10684-712BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.429.723e−09315-343BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.429.836e−11498-526BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.429.852e−10795-823BL00420Speract receptor repeat
proteins domain
proteins.
964BL00420A20.429.862e−09118-146BL00420Speract receptor repeat
proteins domain
proteins.
964BL01113A17.991.000e−10282-308BL01113C1q domain proteins.
964BL01113A17.991.000e−10669-695BL01113C1q domain proteins.
964BL01113A17.991.000e−11591-617BL01113C1q domain proteins.
964BL01113A17.991.000e−12813-839BL01113C1q domain proteins.
964BL01113A17.991.000e−14534-560BL01113C1q domain proteins.
964BL01113A17.991.173e−09357-383BL01113C1q domain proteins.
964BL01113A17.991.191e−10462-488BL01113C1q domain proteins.
964BL01113A17.991.205e−11798-824BL01113C1q domain proteins.
964BL01113A17.991.243e−13660-686BL01113C1q domain proteins.
964BL01113A17.991.519e−09621-647BL01113C1q domain proteins.
964BL01113A17.991.692e−12789-815BL01113C1q domain proteins.
964BL01113A17.991.766e−10339-365BL01113C1q domain proteins.
964BL01113A17.991.766e−10648-674BL01113C1q domain proteins.
964BL01113A17.991.957e−10822-848BL01113C1q domain proteins.
964BL01113A17.991.957e−10879-905BL01113C1q domain proteins.
964BL01113A17.992.149e−10831-857BL01113C1q domain proteins.
964BL01113A17.992.154e−12543-569BL01113C1q domain proteins.
964BL01113A17.992.212e−09231-257BL01113C1q domain proteins.
964BL01113A17.992.212e−09327-353BL01113C1q domain proteins.
964BL01113A17.992.558e−09372-398BL01113C1q domain proteins.
964BL01113A17.992.703e−13112-138BL01113C1q domain proteins.
964BL01113A17.992.723e−10189-215BL01113C1q domain proteins.
964BL01113A17.992.723e−10219-245BL01113C1q domain proteins.
964BL01113A17.992.731e−09555-581BL01113C1q domain proteins.
964BL01113A17.992.742e−15336-362BL01113C1q domain proteins.
964BL01113A17.992.846e−12109-135BL01113C1q domain proteins.
964BL01113A17.992.904e−09207-233BL01113C1q domain proteins.
964BL01113A17.992.904e−09306-332BL01113C1q domain proteins.
964BL01113A17.992.904e−09387-413BL01113C1q domain proteins.
964BL01113A17.992.904e−09564-590BL01113C1q domain proteins.
964BL01113A17.992.915e−10210-236BL01113C1q domain proteins.
964BL01113A17.992.915e−10840-866BL01113C1q domain proteins.
964BL01113A17.992.946e−13846-872BL01113C1q domain proteins.
964BL01113A17.993.077e−09405-431BL01113C1q domain proteins.
964BL01113A17.993.298e−10756-782BL01113C1q domain proteins.
964BL01113A17.993.423e−09495-521BL01113C1q domain proteins.
964BL01113A17.993.423e−09720-746BL01113C1q domain proteins.
964BL01113A17.993.455e−11771-797BL01113C1q domain proteins.
964BL01113A17.993.613e−15115-141BL01113C1q domain proteins.
964BL01113A17.994.000e−14738-764BL01113C1q domain proteins.
964BL01113A17.994.064e−10192-218BL01113C1q domain proteins.
964BL01113A17.994.064e−10345-371BL01113C1q domain proteins.
964BL01113A17.994.064e−10723-749BL01113C1q domain proteins.
964BL01113A17.994.068e−11540-566BL01113C1q domain proteins.
964BL01113A17.994.194e−15118-144BL01113C1q domain proteins.
964BL01113A17.994.231e−12456-482BL01113C1q domain proteins.
964BL01113A17.994.255e−10324-350BL01113C1q domain proteins.
964BL01113A17.994.273e−11195-221BL01113C1q domain proteins.
964BL01113A17.994.288e−09103-129BL01113C1q domain proteins.
964BL01113A17.994.288e−09127-153BL01113C1q domain proteins.
964BL01113A17.994.462e−09246-272BL01113C1q domain proteins.
964BL01113A17.994.635e−09204-230BL01113C1q domain proteins.
964BL01113A17.994.638e−10480-506BL01113C1q domain proteins.
964BL01113A17.994.774e−15297-323BL01113C1q domain proteins.
964BL01113A17.994.808e−09381-407BL01113C1q domain proteins.
964BL01113A17.994.886e−11249-275BL01113C1q domain proteins.
964BL01113A17.994.923e−12531-557BL01113C1q domain proteins.
964BL01113A17.994.981e−09375-401BL01113C1q domain proteins.
964BL01113A17.994.981e−09837-863BL01113C1q domain proteins.
964BL01113A17.995.021e−10705-731BL01113C1q domain proteins.
964BL01113A17.995.091e−11645-671BL01113C1q domain proteins.
964BL01113A17.995.091e−11762-788BL01113C1q domain proteins.
964BL01113A17.995.091e−14807-833BL01113C1q domain proteins.
964BL01113A17.995.385e−12525-551BL01113C1q domain proteins.
964BL01113A17.995.404e−10291-317BL01113C1q domain proteins.
964BL01113A17.995.404e−10852-878BL01113C1q domain proteins.
964BL01113A17.995.500e−11573-599BL01113C1q domain proteins.
964BL01113A17.995.615e−12693-719BL01113C1q domain proteins.
964BL01113A17.995.673e−09447-473BL01113C1q domain proteins.
964BL01113A17.995.673e−09489-515BL01113C1q domain proteins.
964BL01113A17.995.846e−12546-572BL01113C1q domain proteins.
964BL01113A17.995.909e−11582-608BL01113C1q domain proteins.
964BL01113A17.995.979e−10471-497BL01113C1q domain proteins.
964BL01113A17.996.108e−13237-263BL01113C1q domain proteins.
964BL01113A17.996.114e−11804-830BL01113C1q domain proteins.
964BL01113A17.996.318e−11216-242BL01113C1q domain proteins.
964BL01113A17.996.362e−10513-539BL01113C1q domain proteins.
964BL01113A17.996.365e−09333-359BL01113C1q domain proteins.
964BL01113A17.996.365e−09816-842BL01113C1q domain proteins.
964BL01113A17.996.523e−11708-734BL01113C1q domain proteins.
964BL01113A17.996.538e−09732-758BL01113C1q domain proteins.
964BL01113A17.996.538e−12171-197BL01113C1q domain proteins.
964BL01113A17.996.712e−09408-434BL01113C1q domain proteins.
964BL01113A17.996.712e−09603-629BL01113C1q domain proteins.
964BL01113A17.996.745e−10234-260BL01113C1q domain proteins.
964BL01113A17.996.769e−12636-662BL01113C1q domain proteins.
964BL01113A17.996.936e−10777-803BL01113C1q domain proteins.
964BL01113A17.997.128e−10702-728BL01113C1q domain proteins.
964BL01113A17.997.128e−10867-893BL01113C1q domain proteins.
964BL01113A17.997.136e−11537-563BL01113C1q domain proteins.
964BL01113A17.997.231e−09561-587BL01113C1q domain proteins.
964BL01113A17.997.231e−09681-707BL01113C1q domain proteins.
964BL01113A17.997.231e−09855-881BL01113C1q domain proteins.
964BL01113A17.997.273e−14714-740BL01113C1q domain proteins.
964BL01113A17.997.319e−10876-902BL01113C1q domain proteins.
964BL01113A17.997.324e−13186-212BL01113C1q domain proteins.
964BL01113A17.997.404e−09528-554BL01113C1q domain proteins.
964BL01113A17.997.511e−10121-147BL01113C1q domain proteins.
964BL01113A17.997.511e−10657-683BL01113C1q domain proteins.
964BL01113A17.997.545e−11330-356BL01113C1q domain proteins.
964BL01113A17.997.577e−09711-737BL01113C1q domain proteins.
964BL01113A17.997.692e−12729-755BL01113C1q domain proteins.
964BL01113A17.997.692e−12747-773BL01113C1q domain proteins.
964BL01113A17.997.702e−10768-794BL01113C1q domain proteins.
964BL01113A17.997.750e−09684-710BL01113C1q domain proteins.
964BL01113A17.997.750e−09792-818BL01113C1q domain proteins.
964BL01113A17.997.923e−09402-428BL01113C1q domain proteins.
964BL01113A17.997.923e−09549-575BL01113C1q domain proteins.
964BL01113A17.997.923e−09627-653BL01113C1q domain proteins.
964BL01113A17.997.923e−09663-689BL01113C1q domain proteins.
964BL01113A17.997.923e−12180-206BL01113C1q domain proteins.
964BL01113A17.998.054e−13567-593BL01113C1q domain proteins.
964BL01113A17.998.085e−10861-887BL01113C1q domain proteins.
964BL01113A17.998.096e−09315-341BL01113C1q domain proteins.
964BL01113A17.998.096e−09717-743BL01113C1q domain proteins.
964BL01113A17.998.159e−11600-626BL01113C1q domain proteins.
964BL01113A17.998.277e−10642-668BL01113C1q domain proteins.
964BL01113A17.998.297e−13240-266BL01113C1q domain proteins.
964BL01113A17.998.385e−12124-150BL01113C1q domain proteins.
964BL01113A17.998.442e−09774-800BL01113C1q domain proteins.
964BL01113A17.998.468e−10873-899BL01113C1q domain proteins.
964BL01113A17.998.548e−15174-200BL01113C1q domain proteins.
964BL01113A17.998.548e−15672-698BL01113C1q domain proteins.
964BL01113A17.998.636e−14384-410BL01113C1q domain proteins.
964BL01113A17.998.773e−11522-548BL01113C1q domain proteins.
964BL01113A17.998.773e−11552-578BL01113C1q domain proteins.
964BL01113A17.998.788e−09252-278BL01113C1q domain proteins.
964BL01113A17.998.846e−12177-203BL01113C1q domain proteins.
964BL01113A17.999.043e−10366-392BL01113C1q domain proteins.
964BL01113A17.999.129e−15183-209BL01113C1q domain proteins.
964BL01113A17.999.135e−09243-269BL01113C1q domain proteins.
964BL01113A17.999.135e−09465-491BL01113C1q domain proteins.
964BL01113A17.999.182e−14651-677BL01113C1q domain proteins.
964BL01113A17.999.234e−10501-527BL01113C1q domain proteins.
964BL01113A17.999.308e−12198-224BL01113C1q domain proteins.
964BL01113A17.999.308e−12516-542BL01113C1q domain proteins.
964BL01113A17.999.386e−11228-254BL01113C1q domain proteins.
964BL01113A17.999.455e−14426-452BL01113C1q domain proteins.
964BL01113A17.999.538e−12106-132BL01113C1q domain proteins.
964BL01113A17.999.617e−10606-632BL01113C1q domain proteins.
964BL01113A17.999.654e−09585-611BL01113C1q domain proteins.
964BL01113A17.999.654e−09843-869BL01113C1q domain proteins.
964BL01113A17.999.757e−13417-443BL01113C1q domain proteins.
964BL01113A17.999.757e−13435-461BL01113C1q domain proteins.
964BL01113A17.999.809e−10558-584BL01113C1q domain proteins.
964BL01113A17.999.809e−10699-725BL01113C1q domain proteins.
964BL01208B15.831.900e−1377-91BL01208VWFC domain proteins.
964DM01418A20.831.000e−40 955-1002DM01418352 FIBRILLAR COLLAGEN
CARBOXYL-TERMINAL.
964DM01418B22.511.000e−401053-1094DM01418352 FIBRILLAR COLLAGEN
CARBOXYL-TERMINAL.
964DM01418C20.481.000e−401124-1165DM01418352 FIBRILLAR COLLAGEN
CARBOXYL-TERMINAL.
964PR00049D0.007.559e−09176-190PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
964PR00524F5.368.468e−09513-526PR00524CHOLECYSTOKININ TYPE A
RECEPTOR SIGNATURE
965BL00039A18.444.600e−31211-249BL00039DEAD-box subfamily ATP-
dependent helicases
proteins.
965BL00039B19.194.913e−17269-294BL00039DEAD-box subfamily ATP-
dependent helicases
proteins.
965BL00039C15.638.000e−27353-376BL00039DEAD-box subfamily ATP-
dependent helicases
proteins.
965BL00039D21.671.783e−40506-551BL00039DEAD-box subfamily ATP-
dependent helicases
proteins.
965BL000486.396.400e−09612-638BL00048Protamine P1 proteins.
965BL00291A4.499.458e−10630-664BL00291Prion protein.
965PF002717.993.250e−09537-544PF00271Helicases conserved C-
terminal domain
proteins.
966PR00308C3.832.169e−0910-19PR00308TYPE I ANTIFREEZE
PROTEIN SIGNATURE
966PR00456E3.066.625e−1012-26PR00456RIBOSOMAL PROTEIN P2
SIGNATURE
970BL00460A28.671.514e−2457-91BL00460Glutathione peroxidases
selenocysteine
proteins.
970BL00460B9.734.600e−23 99-116BL00460Glutathione peroxidases
selenocysteine
proteins.
970BL00460C14.354.724e−21137-159BL00460Glutathione peroxidases
selenocysteine
proteins.
970BL00460D16.891.818e−22185-204BL00460Glutathione peroxidases
selenocysteine
proteins.
971BL00262A12.484.600e−15124-141BL00262Insulin family
proteins.
971BL00262B16.898.286e−17160-179BL00262Insulin family
proteins.
971PR00276A11.844.750e−13161-170PR00276INSULIN A CHAIN
SIGNATURE
971PR00276B8.027.828e−10170-179PR00276INSULIN A CHAIN
SIGNATURE
971PR00277A14.822.421e−13121-134PR00277INSULIN B CHAIN
SIGNATURE
971PR00277B12.792.350e−11135-147PR00277INSULIN B CHAIN
SIGNATURE
975PF00023A16.035.500e−10132-147PF00023Ank repeat proteins.
975PF00791B28.491.818e−11132-186PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
975PF00791B28.495.046e−09165-219PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
975PF00791B28.496.942e−10 99-153PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
979PF00777A8.254.000e−1052-63PF00777Sialyltransferase
family.
979PF00777B29.691.500e−28 89-131PF00777Sialyltransferase
family.
979PF00777C18.601.000e−40158-212PF00777Sialyltransferase
family.
979PF00777D22.059.325e−39291-336PF00777Sialyltransferase
family.
980BL00171B26.591.125e−16 69-119BL00171Triosephosphate
isomerase proteins.
980BL00171C14.536.294e−36163-195BL00171Triosephosphate
isomerase proteins.
980BL00171D15.751.563e−37211-245BL00171Triosephosphate
isomerase proteins.
981BL00061A9.414.600e−13139-149BL00061Short-chain
dehydrogenases/reductases
family proteins.
981BL00061B25.799.250e−27187-224BL00061Short-chain
dehydrogenases/reductases
family proteins.
981BL00061C7.861.563e−10231-240BL00061Short-chain
dehydrogenases/reductases
family proteins.
981PR00080A9.323.143e−12139-150PR00080ALCOHOL DEHYDROGENASE
SUPERFAMILY SIGNATURE
981PR00080C17.164.429e−13207-226PR00080ALCOHOL DEHYDROGENASE
SUPERFAMILY SIGNATURE
981PR00081A10.534.333e−1463-80PR00081GLUCOSE/RIBITOL
DEHYDROGENASE FAMILY
SIGNATURE
981PR00081B10.388.800e−14139-150PR00081GLUCOSE/RIBITOL
DEHYDROGENASE FAMILY
SIGNATURE
981PR00081D15.805.800e−12207-226PR00081GLUCOSE/RIBITOL
DEHYDROGENASE FAMILY
SIGNATURE
981PR00081E17.549.250e−12230-247PR00081GLUCOSE/RIBITOL
DEHYDROGENASE FAMILY
SIGNATURE
982BL0107324.301.000e−40 51-100BL01073Ribosomal protein L24e
proteins.
985BL00223A15.592.253e−11298-331BL00223Annexins repeat
proteins domain
proteins.
985BL00223A15.598.250e−27138-171BL00223Annexins repeat
proteins domain
proteins.
985BL00223A15.598.750e−2766-99BL00223Annexins repeat
proteins domain
proteins.
985BL00223B28.473.032e−37208-257BL00223Annexins repeat
proteins domain
proteins.
985BL00223C24.791.000e−40285-339BL00223Annexins repeat
proteins domain
proteins.
985BL00223C24.792.735e−15125-179BL00223Annexins repeat
proteins domain
proteins.
985BL00223C24.799.438e−16 53-107BL00223Annexins repeat
proteins domain
proteins.
985PR00196A11.164.676e−10147-169PR00196ANNEXIN FAMILY
SIGNATURE
985PR00196A11.168.773e−2375-97PR00196ANNEXIN FAMILY
SIGNATURE
985PR00196B10.685.050e−17115-131PR00196ANNEXIN FAMILY
SIGNATURE
985PR00196C10.361.443e−1370-91PR00196ANNEXIN FAMILY
SIGNATURE
985PR00196C10.367.968e−21142-163PR00196ANNEXIN FAMILY
SIGNATURE
985PR00196C10.369.609e−11302-323PR00196ANNEXIN FAMILY
SIGNATURE
985PR00196D21.861.818e−23226-252PR00196ANNEXIN FAMILY
SIGNATURE
985PR00196E9.191.900e−0974-94PR00196ANNEXIN FAMILY
SIGNATURE
985PR00196E9.199.100e−22306-326PR00196ANNEXIN FAMILY
SIGNATURE
985PR00196E9.199.763e−10146-166PR00196ANNEXIN FAMILY
SIGNATURE
985PR00196F13.891.720e−14334-349PR00196ANNEXIN FAMILY
SIGNATURE
985PR00196G11.729.333e−14350-363PR00196ANNEXIN FAMILY
SIGNATURE
985PR00197B7.569.786e−1275-97PR00197ANNEXIN TYPE I
SIGNATURE
985PR00197D7.506.242e−10302-323PR00197ANNEXIN TYPE I
SIGNATURE
985PR00197D7.507.207e−1170-91PR00197ANNEXIN TYPE I
SIGNATURE
985PR00197D7.508.500e−15142-163PR00197ANNEXIN TYPE I
SIGNATURE
985PR00197E11.893.415e−14226-252PR00197ANNEXIN TYPE I
SIGNATURE
985PR00197F9.035.757e−17306-326PR00197ANNEXIN TYPE I
SIGNATURE
985PR00197F9.039.724e−09146-166PR00197ANNEXIN TYPE I
SIGNATURE
985PR00198B8.715.400e−1275-97PR00198ANNEXIN TYPE II
SIGNATURE
985PR00198D7.652.113e−10302-323PR00198ANNEXIN TYPE II
SIGNATURE
985PR00198D7.654.812e−13142-163PR00198ANNEXIN TYPE II
SIGNATURE
985PR00198D7.656.155e−0970-91PR00198ANNEXIN TYPE II
SIGNATURE
985PR00198E14.677.698e−14226-252PR00198ANNEXIN TYPE II
SIGNATURE
985PR00198G8.099.407e−10146-166PR00198ANNEXIN TYPE II
SIGNATURE
985PR00198G8.099.486e−16306-326PR00198ANNEXIN TYPE II
SIGNATURE
985PR00198H12.053.025e−09350-363PR00198ANNEXIN TYPE II
SIGNATURE
985PR00199B6.869.316e−1775-97PR00199ANNEXIN TYPE III
SIGNATURE
985PR00199B6.869.518e−09147-169PR00199ANNEXIN TYPE III
SIGNATURE
985PR00199C13.845.680e−11115-131PR00199ANNEXIN TYPE III
SIGNATURE
985PR00199D5.656.013e−12142-163PR00199ANNEXIN TYPE III
SIGNATURE
985PR00199D5.659.609e−09302-323PR00199ANNEXIN TYPE III
SIGNATURE
985PR00199D5.659.750e−1470-91PR00199ANNEXIN TYPE III
SIGNATURE
985PR00199F16.195.565e−15226-252PR00199ANNEXIN TYPE III
SIGNATURE
985PR00199G9.095.821e−14307-332PR00199ANNEXIN TYPE III
SIGNATURE
985PR00199H12.625.632e−09350-363PR00199ANNEXIN TYPE III
SIGNATURE
985PR00200B7.391.429e−10147-169PR00200ANNEXIN TYPE IV
SIGNATURE
985PR00200B7.399.372e−1575-97PR00200ANNEXIN TYPE IV
SIGNATURE
985PR00200D10.018.012e−13115-131PR00200ANNEXIN TYPE IV
SIGNATURE
985PR00200E10.004.522e−1170-91PR00200ANNEXIN TYPE IV
SIGNATURE
985PR00200E10.006.157e−12302-323PR00200ANNEXIN TYPE IV
SIGNATURE
985PR00200E10.007.446e−17142-163PR00200ANNEXIN TYPE IV
SIGNATURE
985PR00200F13.721.228e−17226-252PR00200ANNEXIN TYPE IV
SIGNATURE
985PR00200G9.433.473e−16306-332PR00200ANNEXIN TYPE IV
SIGNATURE
985PR00200G9.436.218e−09146-172PR00200ANNEXIN TYPE IV
SIGNATURE
985PR00200H13.689.775e−10350-363PR00200ANNEXIN TYPE IV
SIGNATURE
985PR00201A6.054.623e−1575-97PR00201ANNEXIN TYPE V
SIGNATURE
985PR00201A6.058.958e−10147-169PR00201ANNEXIN TYPE V
SIGNATURE
985PR00201C11.131.947e−17115-131PR00201ANNEXIN TYPE V
SIGNATURE
985PR00201D10.495.330e−09302-323PR00201ANNEXIN TYPE V
SIGNATURE
985PR00201D10.496.764e−13142-163PR00201ANNEXIN TYPE V
SIGNATURE
985PR00201E12.379.780e−17226-252PR00201ANNEXIN TYPE V
SIGNATURE
985PR00201G11.025.375e−21306-332PR00201ANNEXIN TYPE V
SIGNATURE
985PR00201H12.049.859e−12350-363PR00201ANNEXIN TYPE V
SIGNATURE
985PR00202B11.448.590e−1574-97PR00202ANNEXIN TYPE VI
SIGNATURE
985PR00202C13.345.438e−16115-131PR00202ANNEXIN TYPE VI
SIGNATURE
985PR00202D5.588.813e−13142-163PR00202ANNEXIN TYPE VI
SIGNATURE
985PR00202E13.006.663e−14226-252PR00202ANNEXIN TYPE VI
SIGNATURE
985PR00202G8.015.703e−10146-172PR00202ANNEXIN TYPE VI
SIGNATURE
985PR00202G8.016.357e−18306-332PR00202ANNEXIN TYPE VI
SIGNATURE
985PR00202H9.203.588e−10350-363PR00202ANNEXIN TYPE VI
SIGNATURE
990BL0115913.855.776e−10166-180BL01159WW/rsp5/WWP domain
proteins.
990PR00403A16.829.561e−09151-164PR00403WW DOMAIN SIGNATURE
990PR00403B12.191.184e−11166-180PR00403WW DOMAIN SIGNATURE
991BL01182F10.074.162e−16 9-23BL01182Glycosyl hydrolases
family 35 proteins.
991PR00742I13.546.455e−18 9-25PR00742GLYCOSYL HYDROLASE
FAMILY 35 SIGNATURE
994BL00563A16.737.097e−4026-64BL00563Stathmin family
proteins.
994BL00563B6.081.000e−3265-91BL00563Stathmin family
proteins.
994BL00563C12.832.174e−37 95-124BL00563Stathmin family
proteins.
994BL00563D11.381.000e−40125-160BL00563Stathmin family
proteins.
994BL00563D11.389.609e−09 74-109BL00563Stathmin family
proteins.
994PR00345A13.464.316e−2230-48PR00345STATHMIN FAMILY
SIGNATURE
994PR00345B7.127.750e−3559-87PR00345STATHMIN FAMILY
SIGNATURE
994PR00345C4.545.714e−29 88-111PR00345STATHMIN FAMILY
SIGNATURE
994PR00345D10.976.850e−31112-135PR00345STATHMIN FAMILY
SIGNATURE
994PR00345E8.543.571e−29136-160PR00345STATHMIN FAMILY
SIGNATURE
998PF00846A11.745.537e−09108-154PF00846Hantavirus nucleocapsid
protein.
999BL001428.389.438e−10528-538BL00142Neutral zinc
metallopeptidases,
zinc-binding region
proteins.
999PR00756A12.906.500e−18367-382PR00756MEMBRANE ALANYL
DIPEPTIDASE (M1) FAMILY
SIGNATURE
999PR00756B14.064.000e−14415-430PR00756MEMBRANE ALANYL
DIPEPTIDASE (M1) FAMILY
SIGNATURE
999PR00756C11.606.087e−13492-502PR00756MEMBRANE ALANYL
DIPEPTIDASE (M1) FAMILY
SIGNATURE
999PR00756D10.588.412e−21528-543PR00756MEMBRANE ALANYL
DIPEPTIDASE (M1) FAMILY
SIGNATURE
999PR00756E11.914.375e−16547-559PR00756MEMBRANE ALANYL
DIPEPTIDASE (M1) FAMILY
SIGNATURE
1000BL00139A10.298.457e−11277-286BL00139Eukaryotic thiol
(cysteine) proteases
cysteine proteins.
1000BL00139C9.233.769e−12429-438BL00139Eukaryotic thiol
(cysteine) proteases
cysteine proteins.
1000BL00139D9.243.769e−21447-463BL00139Eukaryotic thiol
(cysteine) proteases
cysteine proteins.
1000PR00705A10.556.000e−13277-292PR00705PAPAIN CYSTEINE
PROTEASE (C1) FAMILY
SIGNATURE
1000PR00705B10.226.143e−12430-440PR00705PAPAIN CYSTEINE
PROTEASE (C1) FAMILY
SIGNATURE
1000PR00705C11.876.824e−09447-453PR00705PAPAIN CYSTEINE
PROTEASE (C1) FAMILY
SIGNATURE
1001PF01008A20.149.333e−14144-164PF01008Initiation factor 2
subunit.
1001PF01008B25.591.964e−32192-234PF01008Initiation factor 2
subunit.
1001PF01008C12.259.667e−18273-292PF01008Initiation factor 2
subunit.
1002BL01164A19.746.063e−23324-353BL01164Copper amine oxidase
topaquinone proteins.
1002BL01164B19.211.818e−21364-390BL01164Copper amine oxidase
topaquinone proteins.
1002BL01164C17.881.563e−23391-419BL01164Copper amine oxidase
topaquinone proteins.
1002BL01164D19.791.333e−33470-504BL01164Copper amine oxidase
topaquinone proteins.
1002BL01164E13.776.000e−18530-547BL01164Copper amine oxidase
topaquinone proteins.
1002BL01164F19.035.091e−28677-706BL01164Copper amine oxidase
topaquinone proteins.
1002PR00766A16.195.500e−23 86-105PR00766AMILORIDE-SENSITIVE
AMINE OXIDASE SIGNATURE
1002PR00766B10.584.706e−25115-134PR00766AMILORIDE-SENSITIVE
AMINE OXIDASE SIGNATURE
1002PR00766C15.504.130e−23204-224PR00766AMILORIDE-SENSITIVE
AMINE OXIDASE SIGNATURE
1002PR00766D9.151.000e−26227-247PR00766AMILORIDE-SENSITIVE
AMINE OXIDASE SIGNATURE
1002PR00766E9.592.421e−27361-382PR00766AMILORIDE-SENSITIVE
AMINE OXIDASE SIGNATURE
1002PR00766F15.104.522e−28439-462PR00766AMILORIDE-SENSITIVE
AMINE OXIDASE SIGNATURE
1002PR00766G11.621.643e−27678-698PR00766AMILORIDE-SENSITIVE
AMINE OXIDASE SIGNATURE
1004PF0064211.593.700e−16166-176PF00642Zinc finger C-x8-C-x5-
C-x3-H type (and
similar).
1004PF0064211.597.900e−12128-138PF00642Zinc finger C-x8-C-x5-
C-x3-H type (and
similar).
1007BL001428.384.857e−09582-592BL00142Neutral zinc
metallopeptidases,
zinc-binding region
proteins.
1007PR00786A11.124.857e−13536-548PR00786NEPRILYSIN
METALLOPROTEASE (M13)
FAMILY SIGNATURE
1007PR00786B9.598.000e−17554-566PR00786NEPRILYSIN
METALLOPROTEASE (M13)
FAMILY SIGNATURE
1007PR00786C9.762.000e−22575-591PR00786NEPRILYSIN
METALLOPROTEASE (M13)
FAMILY SIGNATURE
1007PR00786D9.785.500e−14648-659PR00786NEPRILYSIN
METALLOPROTEASE (M13)
FAMILY SIGNATURE
1008BL00232A27.723.739e−26 82-114BL00232Cadherins extracellular
repeat proteins domain
proteins.
1008BL00232B32.795.125e−40174-221BL00232Cadherins extracellular
repeat proteins domain
proteins.
1008BL00232B32.799.286e−19281-328BL00232Cadherins extracellular
repeat proteins domain
proteins.
1008BL00232C10.656.143e−16279-296BL00232Cadherins extracellular
repeat proteins domain
proteins.
1008BL00232D16.253.842e−13796-810BL00232Cadherins extracellular
repeat proteins domain
proteins.
1008PR00205A14.734.000e−12206-221PR00205CADHERIN SIGNATURE
1008PR00205B11.392.241e−16279-296PR00205CADHERIN SIGNATURE
1008PR00205C13.652.688e−10540-554PR00205CADHERIN SIGNATURE
1009BL00262A12.483.829e−0957-74BL00262Insulin family
proteins.
1009BL00262B16.894.977e−11146-165BL00262Insulin family
proteins.
1010PF000135.784.150e−09127-138PF00013KH domain proteins
family of RNA binding
proteins.
1011BL00719A16.667.488e−09 88-101BL00719Glycosyl hydrolases
family 2 proteins.
1013BL00412D16.546.969e−09 75-125BL00412Neuromodulin (GAP-43)
proteins.
1014PR00449D10.798.364e−1255-68PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1014PR00449E13.504.706e−11 90-112PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1015PD02870B18.833.872e−09345-377PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1016BL00022B7.541.000e−08328-334BL00022EGF-like domain
proteins.
1016BL01177C17.393.286e−09394-412BL01177Anaphylatoxin domain
proteins.
1016BL01177C17.395.119e−10352-370BL01177Anaphylatoxin domain
proteins.
1016BL01187A9.982.286e−13343-354BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1016BL01187A9.984.750e−09383-394BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1016BL01187B12.041.900e−09276-291BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1016BL01187B12.043.667e−12358-373BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1016BL01187B12.048.200e−14443-458BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1016BL01187B12.048.826e−13400-415BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1016PD00919A11.535.227e−09306-317PD00919CALCIUM-BINDING
PRECURSOR SIGNAL R.
1016PR00255E15.239.882e−09586-608PR00255NATRIURETIC PEPTIDE
RECEPTOR SIGNATURE
1016PR00352B13.516.400e−09240-250PR003523FE-4S FERREDOXIN
SIGNATURE
1016PR00907G11.631.243e−09400-426PR00907THROMBOMODULIN
SIGNATURE
1020BL00222B11.091.878e−12114-129BL00222Insulin-like growth
factor binding
proteins.
1020BL00222B11.093.250e−16100-115BL00222Insulin-like growth
factor binding
proteins.
1020BL00222C22.977.900e−25158-185BL00222Insulin-like growth
factor binding
proteins.
1020BL01185A8.116.318e−16100-111BL01185C-terminal cystine knot
proteins.
1020BL01185B21.141.000e−40151-199BL01185C-terminal cystine knot
proteins.
1020BL01185C15.862.038e−37247-285BL01185C-terminal cystine knot
proteins.
1020BL01185D23.451.000e−40321-373BL01185C-terminal cystine knot
proteins.
1020BL01208B15.835.500e−12247-261BL01208VWFC domain proteins.
1020BL01208C14.166.400e−11280-290BL01208VWFC domain proteins.
1021BL00030A14.399.571e−09 9-27BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
1021BL00030B7.031.000e−1240-49BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
1021BL000486.391.000e−12294-320BL00048Protamine P1 proteins.
1021BL000486.392.059e−12293-319BL00048Protamine P1 proteins.
1021BL000486.392.324e−12295-321BL00048Protamine P1 proteins.
1021BL000486.392.913e−09308-334BL00048Protamine P1 proteins.
1021BL000486.392.938e−13296-322BL00048Protamine P1 proteins.
1021BL000486.393.125e−11284-310BL00048Protamine P1 proteins.
1021BL000486.393.250e−11291-317BL00048Protamine P1 proteins.
1021BL000486.393.625e−11282-308BL00048Protamine P1 proteins.
1021BL000486.393.700e−09275-301BL00048Protamine P1 proteins.
1021BL000486.393.724e−10306-332BL00048Protamine P1 proteins.
1021BL000486.393.750e−11298-324BL00048Protamine P1 proteins.
1021BL000486.394.046e−13283-309BL00048Protamine P1 proteins.
1021BL000486.394.176e−12304-330BL00048Protamine P1 proteins.
1021BL000486.394.671e−10292-318BL00048Protamine P1 proteins.
1021BL000486.395.015e−13281-307BL00048Protamine P1 proteins.
1021BL000486.395.125e−11302-328BL00048Protamine P1 proteins.
1021BL000486.395.145e−10337-363BL00048Protamine P1 proteins.
1021BL000486.395.500e−10278-304BL00048Protamine P1 proteins.
1021BL000486.395.846e−13285-311BL00048Protamine P1 proteins.
1021BL000486.395.974e−10276-302BL00048Protamine P1 proteins.
1021BL000486.396.092e−10305-331BL00048Protamine P1 proteins.
1021BL000486.396.329e−10273-299BL00048Protamine P1 proteins.
1021BL000486.396.400e−09303-329BL00048Protamine P1 proteins.
1021BL000486.397.492e−14289-315BL00048Protamine P1 proteins.
1021BL000486.397.500e−11301-327BL00048Protamine P1 proteins.
1021BL000486.397.785e−13279-305BL00048Protamine P1 proteins.
1021BL000486.398.377e−14297-323BL00048Protamine P1 proteins.
1021BL000486.398.538e−09339-365BL00048Protamine P1 proteins.
1021BL000486.398.627e−15277-303BL00048Protamine P1 proteins.
1021BL000486.398.672e−14287-313BL00048Protamine P1 proteins.
1021BL000486.398.816e−10280-306BL00048Protamine P1 proteins.
1021BL000486.398.941e−12286-312BL00048Protamine P1 proteins.
1021BL000486.399.000e−11299-325BL00048Protamine P1 proteins.
1021BL000486.399.100e−09312-338BL00048Protamine P1 proteins.
1021BL000486.399.308e−13300-326BL00048Protamine P1 proteins.
1021BL000486.399.723e−13290-316BL00048Protamine P1 proteins.
1021BL000486.399.735e−12288-314BL00048Protamine P1 proteins.
1021DM01206B10.691.000e−08291-310DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.691.134e−11287-306DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.693.284e−11285-304DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.693.734e−09310-329DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.694.714e−12289-308DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.695.433e−11283-302DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.695.438e−10281-300DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.695.671e−09346-365DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.695.970e−11304-323DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.696.918e−10306-325DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.697.714e−12279-298DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.697.835e−09293-312DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.697.949e−09302-321DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.698.105e−13308-327DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.698.105e−13312-331DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1021DM01206B10.698.291e−09277-296DM01206CORONAVIRUS
NUCLEOCAPSID PROTEIN.
1022BL00345A13.963.903e−14406-424BL00345Ets-domain proteins.
1022BL00345B21.281.000e−40439-489BL00345Ets-domain proteins.
1022PD01234B15.533.893e−09507-524PD01234PROTEIN NUCLEAR
BROMODOMAIN TRANS.
1022PR00454A13.646.625e−13410-423PR00454ETS DOMAIN SIGNATURE
1022PR00454B20.783.625e−18434-452PR00454ETS DOMAIN SIGNATURE
1022PR00454C11.245.065e−22453-471PR00454ETS DOMAIN SIGNATURE
1022PR00454D10.895.950e−19472-490PR00454ETS DOMAIN SIGNATURE
1023BL0051118.401.429e−31193-224BL00511Corticotropin-releasing
factor family proteins.
1027BL00456A22.598.527e−09 87-141BL00456Sodium: solute symporter
family proteins.
1027BL00456C24.554.000e−22223-277BL00456Sodium: solute symporter
family proteins.
1029BL00360A16.976.478e−2319-45BL00360Ribosomal protein S9
proteins.
1029BL00360B20.225.286e−2962-97BL00360Ribosomal protein S9
proteins.
1029BL00360C17.658.105e−27125-151BL00360Ribosomal protein S9
proteins.
1031BL00406A9.951.000e−4031-65BL00406Actins proteins.
1031BL00406B5.471.000e−40107-161BL00406Actins proteins.
1031BL00406C6.751.000e−40166-220BL00406Actins proteins.
1031BL00406D12.581.000e−40293-347BL00406Actins proteins.
1031BL00406E8.441.000e−40350-399BL00406Actins proteins.
1031PR00190A7.241.375e−1350-59PR00190ACTIN SIGNATURE
1031PR00190B9.981.000e−1573-84PR00190ACTIN SIGNATURE
1031PR00190C11.491.474e−30 85-107PR00190ACTIN SIGNATURE
1031PR00190D19.231.450e−26108-126PR00190ACTIN SIGNATURE
1031PR00190E7.161.450e−19139-152PR00190ACTIN SIGNATURE
1031PR00190F7.802.286e−24164-183PR00190ACTIN SIGNATURE
1031PR00190G12.621.600e−21260-276PR00190ACTIN SIGNATURE
1032BL00180A13.205.065e−14199-211BL00180Glutamine synthetase
proteins.
1032BL00180B18.034.971e−14235-253BL00180Glutamine synthetase
proteins.
1032BL00180C12.144.600e−14269-278BL00180Glutamine synthetase
proteins.
1032BL00180D13.262.174e−24286-307BL00180Glutamine synthetase
proteins.
1032BL00180E17.601.000e−40321-372BL00180Glutamine synthetase
proteins.
1032BL00180F10.056.211e−17385-397BL00180Glutamine synthetase
proteins.
1032BL00180G10.208.435e−17474-488BL00180Glutamine synthetase
proteins.
1034BL00021B13.338.984e−12545-562BL00021Kringle domain
proteins.
1034BL00134A11.965.781e−15545-561BL00134Serine proteases,
trypsin family,
histidine proteins.
1034BL00134B15.994.194e−14727-750BL00134Serine proteases,
trypsin family,
histidine proteins.
1034BL00495N11.049.735e−11719-753BL00495Apple domain proteins.
1034BL01253G11.345.348e−09726-739BL01253Type I fibronectin
domain proteins.
1034PR00453A12.795.345e−14303-320PR00453VON WILLEBRAND FACTOR
TYPE A DOMAIN SIGNATURE
1034PR00453B14.654.682e−10342-356PR00453VON WILLEBRAND FACTOR
TYPE A DOMAIN SIGNATURE
1034PR00722A12.279.129e−13546-561PR00722CHYMOTRYPSIN SERINE
PROTEASE FAMILY (S1)
SIGNATURE
1034PR00722B12.514.000e−09606-620PR00722CHYMOTRYPSIN SERINE
PROTEASE FAMILY (S1)
SIGNATURE
1034PR00722C10.874.273e−11726-738PR00722CHYMOTRYPSIN SERINE
PROTEASE FAMILY (S1)
SIGNATURE
1036BL000187.417.300e−10219-231BL00018EF-hand calcium-binding
domain proteins.
1037BL000369.026.786e−1386-98BL00036bZIP transcription
factors basic domain
proteins.
1037PR00041C16.238.875e−1636-47PR00041CAMP RESPONSE ELEMENT
BINDING (CREB) PROTEIN
SIGNATURE
1037PR00041D7.954.750e−2174-90PR00041CAMP RESPONSE ELEMENT
BINDING (CREB) PROTEIN
SIGNATURE
1037PR00041E7.201.243e−27 92-112PR00041CAMP RESPONSE ELEMENT
BINDING (CREB) PROTEIN
SIGNATURE
1037PR00041F8.532.125e−22112-129PR00041CAMP RESPONSE ELEMENT
BINDING (CREB) PROTEIN
SIGNATURE
1038PD0021015.257.231e−1647-62PD00210PROTEIN ANTIOXIDANT
PEROXIDASE RED.
1039BL0002816.076.143e−09440-456BL00028Zinc finger, C2H2 type,
domain proteins.
1039BL0002816.078.826e−12382-398BL00028Zinc finger, C2H2 type,
domain proteins.
1039PD0006613.926.870e−11398-410PD00066PROTEIN ZINC-FINGER
METAL-BINDI.
1039PR00048A10.529.280e−09379-392PR00048C2H2-TYPE ZINC FINGER
SIGNATURE
1039PR00308C3.838.714e−0966-75PR00308TYPE I ANTIFREEZE
PROTEIN SIGNATURE
1039PR00558C6.545.846e−0937-56PR00558ALPHA-2A ADRENERGIC
RECEPTOR SIGNATURE
1040BL001428.382.688e−10351-361BL00142Neutral zinc
metallopeptidases,
zinc-binding region
proteins.
1040BL0042713.938.375e−25454-508BL00427Disintegrins proteins.
1040PR00289A13.627.525e−18468-487PR00289DISINTEGRIN SIGNATURE
1040PR00289B11.795.245e−10497-509PR00289DISINTEGRIN SIGNATURE
1040PR00451A6.495.696e−10466-474PR00451CHITIN-BINDING DOMAIN
SIGNATURE
1041BL01271A8.065.333e−21147-166BL01271Sodium: sulfate
symporter family
proteins.
1041BL01271A8.068.986e−09487-506BL01271Sodium: sulfate
symporter family
proteins.
1041BL01271B12.024.375e−19246-270BL01271Sodium: sulfate
symporter family
proteins.
1041BL01271C13.628.714e−20438-459BL01271Sodium: sulfate
symporter family
proteins.
1041BL01271D25.262.532e−32511-565BL01271Sodium: sulfate
symporter family
proteins.
1042PR00371E14.061.000e−1066-75PR00371FLAVOPROTEIN PYRIDINE
NUCLEOTIDE CYTOCHROME
REDUCTASE SIGNATURE
1042PR00371F10.125.135e−0979-90PR00371FLAVOPROTEIN PYRIDINE
NUCLEOTIDE CYTOCHROME
REDUCTASE SIGNATURE
1043BL00021B13.331.265e−20120-137BL00021Kringle domain
proteins.
1043BL00021C22.219.250e−10203-224BL00021Kringle domain
proteins.
1043BL00021D24.569.813e−25290-331BL00021Kringle domain
proteins.
1043BL00134A11.965.737e−19120-136BL00134Serine proteases,
trypsin family,
histidine proteins.
1043BL00134B15.997.231e−16282-305BL00134Serine proteases,
trypsin family,
histidine proteins.
1043BL00134C13.451.692e−11318-331BL00134Serine proteases,
trypsin family,
histidine proteins.
1043BL00495K12.588.600e−12122-154BL00495Apple domain proteins.
1043BL00495L11.946.757e−10155-193BL00495Apple domain proteins.
1043BL00495M8.504.058e−10194-228BL00495Apple domain proteins.
1043BL00495N11.041.409e−27274-308BL00495Apple domain proteins.
1043BL00495O13.757.459e−13309-337BL00495Apple domain proteins.
1043BL01253D4.845.500e−12120-133BL01253Type I fibronectin
domain proteins.
1043BL01253E16.018.579e−15192-228BL01253Type I fibronectin
domain proteins.
1043BL01253G11.341.000e−15281-294BL01253Type I fibronectin
domain proteins.
1043BL01253H13.155.500e−20300-334BL01253Type I fibronectin
domain proteins.
1043PR00722A12.278.941e−18121-136PR00722CHYMOTRYPSIN SERINE
PROTEASE FAMILY (S1)
SIGNATURE
1043PR00722B12.514.000e−09180-194PR00722CHYMOTRYPSIN SERINE
PROTEASE FAMILY (S1)
SIGNATURE
1043PR00722C10.875.235e−13281-293PR00722CHYMOTRYPSIN SERINE
PROTEASE FAMILY (S1)
SIGNATURE
1045BL00022B7.548.200e−09865-871BL00022EGF-like domain
proteins.
1045BL00279E37.119.241e−10 66-113BL00279Membrane attack complex
components/perforin
proteins.
1045BL01187A9.981.000e−08715-726BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187A9.982.875e−09921-932BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187A9.987.000e−09592-603BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187A9.987.857e−10756-767BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187A9.989.526e−11675-686BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187B12.041.257e−101161-1176BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187B12.041.391e−13321-336BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187B12.042.350e−14856-871BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187B12.044.130e−13897-912BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187B12.044.600e−11939-954BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187B12.044.913e−13773-788BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187B12.045.500e−14814-829BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187B12.047.000e−171360-1375BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187B12.049.229e−101315-1330BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187B12.049.609e−13610-625BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045BL01187B12.049.667e−12732-747BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1045PD00919B9.477.485e−10697-711PD00919CALCIUM-BINDING
PRECURSOR SIGNAL R.
1045PR00009C14.119.118e−09736-747PR00009TYPE I EGF SIGNATURE
1045PR00010C11.161.857e−09615-625PR00010TYPE II EGF-LIKE
SIGNATURE
1045PR00010C11.164.857e−091365-1375PR00010TYPE II EGF-LIKE
SIGNATURE
1045PR00010C11.167.545e−101320-1330PR00010TYPE II EGF-LIKE
SIGNATURE
1045PR00010C11.167.667e−11861-871PR00010TYPE II EGF-LIKE
SIGNATURE
1045PR00011D14.032.696e−09 92-110PR00011TYPE III EGF-LIKE
SIGNATURE
1045PR00907G11.637.973e−09568-594PR00907THROMBOMODULIN
SIGNATURE
1048BL00352A12.197.000e−14377-391BL00352‘Cold-shock’ DNA-
binding domain
proteins.
1048BL00352B23.662.000e−20737-775BL00352‘Cold-shock’ DNA-
binding domain
proteins.
1050BL00326A14.016.128e−091284-1317BL00326Tropomyosins proteins.
1050BL00447C13.799.813e−09198-212BL00447DNA polymerase family A
proteins.
1050DM0021519.437.712e−091026-1058DM00215PROLINE-RICH PROTEIN 3.
1050PD00301B5.496.885e−091095-1105PD00301PROTEIN REPEAT MUSCLE
CALCIUM-BI.
1050PF00992A16.671.355e−091297-1331PF00992Troponin.
1050PF00992A16.674.434e−091289-1323PF00992Troponin.
1050PF00992A16.677.513e−091298-1332PF00992Troponin.
1050PF01140D15.541.628e−091073-1107PF011040Matrix protein (MA),
p15.
1050PF01140D15.544.872e−091295-1329PF01140Matrix protein (MA),
p15.
1051BL00310A14.057.000e−1561-75BL00310Lysosome-associated
membrane glycoproteins
duplicated domain
proteins.
1051BL00310B22.335.034e−32113-148BL00310Lysosome-associated
membrane glycoproteins
duplicated domain
proteins.
1051BL00310C26.353.400e−39166-212BL00310Lysosome-associated
membrane glycoproteins
duplicated domain
proteins.
1051BL00310D14.977.818e−28238-264BL00310Lysosome-associated
membrane glycoproteins
duplicated domain
proteins.
1051BL00310E19.922.250e−24339-363BL00310Lysosome-associated
membrane glycoproteins
duplicated domain
proteins.
1051BL00310F23.261.000e−40374-428BL00310Lysosome-associated
membrane glycoproteins
duplicated domain
proteins.
1051PR00336A12.869.727e−24241-265PR00336LYSOSOME-ASSOCIATED
MEMBRANE GLYCOPROTEIN
SIGNATURE
1051PR00336B15.424.000e−16351-365PR00336LYSOSOME-ASSOCIATED
MEMBRANE GLYCOPROTEIN
SIGNATURE
1051PR00336C14.479.333e−12388-400PR00336LYSOSOME-ASSOCIATED
MEMBRANE GLYCOPROTEIN
SIGNATURE
1051PR00336D9.964.150e−24402-424PR00336LYSOSOME-ASSOCIATED
MEMBRANE GLYCOPROTEIN
SIGNATURE
1051PR00336E11.593.382e−13425-437PR00336LYSOSOME-ASSOCIATED
MEMBRANE GLYCOPROTEIN
SIGNATURE
1052PF00550B10.272.588e−10129-142PF00550Phosphopantetheine
attachment site
proteins.
1055BL00690A6.873.455e−12424-433BL00690DEAH-box subfamily ATP-
dependent helicases
proteins.
1055BL00690B13.386.571e−16453-470BL00690DEAH-box subfamily ATP-
dependent helicases
proteins.
1055BL00690C7.517.429e−10519-528BL00690DEAH-box subfamily ATP-
dependent helicases
proteins.
1056PR00704A14.687.375e−2260-83PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1056PR00704B17.946.276e−23105-127PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1056PR00704C11.886.625e−20129-145PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1056PR00704D11.055.065e−29165-190PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1056PR00704E12.558.875e−28195-218PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1056PR00704F13.617.632e−30220-247PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1056PR00704G13.871.391e−25350-371PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1056PR00704H13.389.217e−22400-417PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1056PR00704I9.521.000e−30508-536PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1057BL01108A20.332.241e−22135-167BL01108Ribosomal protein L24
proteins.
1057BL01108B11.408.457e−10182-192BL01108Ribosomal protein L24
proteins.
1058BL00250A21.244.130e−27263-298BL00250TGF-beta family
proteins.
1058BL00250B27.373.000e−20331-366BL00250TGF-beta family
proteins.
1058PR00669A12.844.414e−31110-134PR00669INHIBIN ALPHA CHAIN
SIGNATURE
1058PR00669B8.276.927e−20188-204PR00669INHIBIN ALPHA CHAIN
SIGNATURE
1058PR00669C14.901.220e−21206-223PR00669INHIBIN ALPHA CHAIN
SIGNATURE
1058PR00669D7.365.974e−25241-260PR00669INHIBIN ALPHA CHAIN
SIGNATURE
1058PR00669E16.283.152e−23263-280PR00669INHIBIN ALPHA CHAIN
SIGNATURE
1058PR00669F5.576.077e−25280-297PR00669INHIBIN ALPHA CHAIN
SIGNATURE
1058PR00669G7.468.650e−26324-343PR00669INHIBIN ALPHA CHAIN
SIGNATURE
1058PR00669H19.133.893e−29345-366PR00669INHIBIN ALPHA CHAIN
SIGNATURE
1058PR00712A6.077.722e−10 4-20PR00712BRAIN NATRIURETIC
PEPTIDE SIGNATURE
1059PR00854B7.302.519e−10 5-22PR00854PROSTAGLANDIN D
RECEPTOR SIGNATURE
1063PR00846A15.431.818e−1349-61PR00846GLYCOSYL HYDROLASE
FAMILY 56 SIGNATURE
1063PR00846B13.977.750e−17109-123PR00846GLYCOSYL HYDROLASE
FAMILY 56 SIGNATURE
1063PR00846C12.185.696e−23141-158PR00846GLYCOSYL HYDROLASE
FAMILY 56 SIGNATURE
1063PR00846D17.964.130e−29199-224PR00846GLYCOSYL HYDROLASE
FAMILY 56 SIGNATURE
1063PR00846E12.073.700e−17248-262PR00846GLYCOSYL HYDROLASE
FAMILY 56 SIGNATURE
1063PR00846F14.275.875e−13353-366PR00846GLYCOSYL HYDROLASE
FAMILY 56 SIGNATURE
1064BL00226A12.772.543e−12 97-111BL00226Intermediate filaments
proteins.
1064BL00226B23.861.000e−31197-244BL00226Intermediate filaments
proteins.
1064BL00226B23.867.600e−11148-195BL00226Intermediate filaments
proteins.
1064BL00226C13.231.000e−22263-293BL00226Intermediate filaments
proteins.
1064BL00226D19.101.000e−40364-410BL00226Intermediate filaments
proteins.
1064PR00042D8.975.793e−09325-346PR00042FOS TRANSFORMING
PROTEIN SIGNATURE
1066BL00610B23.659.265e−0938-87BL00610Sodium: neurotransmitter
symporter family
proteins.
1067BL00965B17.779.735e−11146-172BL00965Phosphomannose
isomerase type I
proteins.
1067BL00965C23.781.225e−14341-389BL00965Phosphomannose
isomerase type I
proteins.
1067PF00801B23.636.344e−11289-316PF00801PKD domain proteins.
1067PR00049D0.005.689e−11319-333PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1067PR00049D0.006.643e−10321-335PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1067PR00049D0.009.786e−10323-337PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1067PR00910A2.518.393e−09323-335PR00910LUTEOVIRUS ORF6 PROTEIN
SIGNATURE
1069BL01019A13.209.520e−1358-97BL01019ADP-ribosylation
factors family
proteins.
1069BL01115A10.225.075e−1124-67BL01115GTP-binding nuclear
protein ran proteins.
1069PR00449A13.205.846e−2124-45PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1069PR00449B14.345.500e−1347-63PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1069PR00449C17.273.700e−2465-87PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1069PR00449D10.794.273e−12127-140PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1069PR00449E13.507.000e−19162-184PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1070BL00415B9.919.404e−09731-766BL00415Synapsins proteins.
1070BL00415N4.297.832e−091057-1100BL00415Synapsins proteins.
1070BL00904A8.306.489e−09496-545BL00904Protein
prenyltransferases
alpha subunit repeat
proteins proteins.
1070DM0021519.433.746e−091043-1075DM00215PROLINE-RICH PROTEIN 3.
1070PR00049D0.002.831e−091299-1313PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1070PR00049D0.008.169e−091301-1315PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1070PR00628A14.818.134e−19233-252PR00628INSULIN RECEPTOR
SUBSTRATE-1 PTB DOMAIN
SIGNATURE
1070PR00628B14.712.556e−15254-274PR00628INSULIN RECEPTOR
SUBSTRATE-1 PTB DOMAIN
SIGNATURE
1070PR00628C16.379.289e−16276-292PR00628INSULIN RECEPTOR
SUBSTRATE-1 PTB DOMAIN
SIGNATURE
1070PR00628D15.474.000e−15293-305PR00628INSULIN RECEPTOR
SUBSTRATE-1 PTB DOMAIN
SIGNATURE
1070PR00628F16.748.116e−18317-341PR00628INSULIN RECEPTOR
SUBSTRATE-1 PTB DOMAIN
SIGNATURE
1071BL00143A20.914.808e−22116-142BL00143Insulinase family,
zinc-binding region
proteins.
1071BL00143B14.413.077e−13162-176BL00143Insulinase family,
zinc-binding region
proteins.
1071BL00143C14.167.000e−11264-276BL00143Insulinase family,
zinc-binding region
proteins.
1072PF00686C12.338.740e−11320-340PF00686Starch binding domain
proteins.
1074DM0021519.432.220e−0941-73DM00215PROLINE-RICH PROTEIN 3.
1074DM0021519.433.593e−09 77-109DM00215PROLINE-RICH PROTEIN 3.
1074DM0021519.438.780e−09 84-116DM00215PROLINE-RICH PROTEIN 3.
1074DM0021519.439.847e−09 81-113DM00215PROLINE-RICH PROTEIN 3.
1074PR00049D0.004.966e−0977-91PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1074PR00049D0.009.237e−09101-115PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1076BL00022B7.546.400e−09672-678BL00022EGF-like domain
proteins.
1076BL00243H17.539.526e−09570-595BL00243Integrins beta chain
cysteine-rich domain
proteins.
1076BL00243I31.774.549e−092113-2155BL00243Integrins beta chain
cysteine-rich domain
proteins.
1076BL00790E29.587.964e−11548-595BL00790Receptor tyrosine
kinase class V
proteins.
1076BL0124811.021.000e−11346-358BL01248Laminin-type EGF-like
(LE) domain proteins.
1076BL0124811.022.895e−161905-1917BL01248Laminin-type EGF-like
(LE) domain proteins.
1076BL0124811.023.377e−09539-551BL01248Laminin-type EGF-like
(LE) domain proteins.
1076BL0124811.025.415e−09629-641BL01248Laminin-type EGF-like
(LE) domain proteins.
1076BL0124811.026.625e−102016-2028BL01248Laminin-type EGF-like
(LE) domain proteins.
1076BL0124811.027.000e−14418-430BL01248Laminin-type EGF-like
(LE) domain proteins.
1076BL0124811.028.132e−092112-2124BL01248Laminin-type EGF-like
(LE) domain proteins.
1076BL0124811.028.302e−092146-2158BL01248Laminin-type EGF-like
(LE) domain proteins.
1076BL0124811.028.302e−09575-587BL01248Laminin-type EGF-like
(LE) domain proteins.
1076BL0124811.029.491e−091574-1586BL01248Laminin-type EGF-like
(LE) domain proteins.
1076PD00320A14.497.750e−09352-365PD00320LAMININ CHAIN EGF-LIKE
DOMAIN P.
1076PD00320A14.499.357e−09827-840PD00320LAMININ CHAIN EGF-LIKE
DOMAIN P.
1076PR00011A14.061.196e−171611-1629PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011A14.061.391e−10575-593PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011A14.062.452e−12462-480PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011A14.062.875e−16711-729PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011A14.063.625e−161565-1583PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011A14.065.271e−13863-881PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011A14.065.313e−16812-830PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011A14.066.081e−122103-2121PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011A14.067.873e−141513-1531PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011A14.069.660e−151472-1490PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011A14.069.673e−142055-2073PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011A14.069.710e−12530-548PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011A14.069.830e−152146-2164PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011B13.081.458e−131611-1629PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011B13.081.610e−13812-830PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011B13.081.614e−172055-2073PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011B13.081.692e−15575-593PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011B13.081.740e−09530-548PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011B13.081.833e−142103-2121PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011B13.083.177e−12462-480PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011B13.083.942e−151565-1583PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011B13.084.500e−142146-2164PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011B13.085.875e−16711-729PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011B13.088.017e−131472-1490PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011B13.089.217e−101513-1531PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011B13.089.862e−11863-881PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011C24.251.450e−101618-1646PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011C24.254.571e−09766-794PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011C24.255.143e−092122-2150PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011C24.258.714e−09546-574PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.031.551e−14462-480PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.032.328e−111472-1490PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.032.653e−142103-2121PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.033.361e−11530-548PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.033.800e−151611-1629PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.033.803e−11863-881PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.034.375e−162055-2073PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.034.836e−11812-830PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.035.224e−14575-593PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.035.500e−171565-1583PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.035.826e−091513-1531PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.036.815e−10665-683PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.037.344e−11620-638PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.037.975e−16711-729PR00011TYPE III EGF-LIKE
SIGNATURE
1076PR00011D14.039.000e−152146-2164PR00011TYPE III EGF-LIKE
SIGNATURE
1077BL01107A12.031.000e−4010-52BL01107Ribosomal protein L27e
proteins.
1077BL01107B16.281.000e−4053-96BL01107Ribosomal protein L27e
proteins.
1077BL01107C9.886.344e−26122-143BL01107Ribosomal protein L27e
proteins.
1077BL01170A12.349.124e−10 7-42BL01170Ribosomal protein L6e
proteins.
1078BL01019A13.208.694e−18107-146BL01019ADP-ribosylation
factors family
proteins.
1078BL01019B19.498.603e−21151-205BL01019ADP-ribosylation
factors family
proteins.
1078BL01020C15.357.722e−20135-185BL01020SAR1 family proteins.
1078BL01115A10.229.151e−11 77-120BL01115GTP-binding nuclear
protein ran proteins.
1078PR00328C13.162.111e−12134-159PR00328GTP-BINDING SAR1
PROTEIN SIGNATURE
1078PR00328D12.568.071e−11179-200PR00328GTP-BINDING SAR1
PROTEIN SIGNATURE
1080BL01243C14.195.111e−13165-199BL01243Uncharacterized protein
family UPF0005
proteins.
1080BL01243D21.159.581e−11247-281BL01243Uncharacterized protein
family UPF0005
proteins.
1081BL00292A22.876.786e−24111-144BL00292Cyclins proteins.
1081BL00292B20.313.739e−19154-184BL00292Cyclins proteins.
1082BL01013A25.141.000e−34489-524BL01013Oxysterol-binding
protein family
proteins.
1082BL01013B11.333.813e−14554-564BL01013Oxysterol-binding
protein family
proteins.
1082BL01013C9.976.211e−14577-586BL01013Oxysterol-binding
protein family
proteins.
1082BL01013D26.811.000e−37775-818BL01013Oxysterol-binding
protein family
proteins.
1083PF00075D10.718.929e−10305-315PF00075RNase H.
1085PR00237B13.506.000e−0968-89PR00237RHODOPSIN-LIKE GPCR
SUPERFAMILY SIGNATURE
1090BL00218B21.441.621e−10103-134BL00218Amino acid permeases
proteins.
1090BL00218D21.493.797e−11271-315BL00218Amino acid permeases
proteins.
1090BL00218E23.303.520e−10352-391BL00218Amino acid permeases
proteins.
1092BL00061A9.418.435e−09107-117BL00061Short-chain
dehydrogenases/reductases
family proteins.
1092BL00061B25.795.605e−09171-208BL00061Short-chain
dehydrogenases/reductases
family proteins.
1092BL00061C7.868.941e−09213-222BL00061Short-chain
dehydrogenases/reductases
family proteins.
1092PF00426W7.962.765e−0925-51PF00426Outer Capsid protein
VP4 (Hemagglutinin).
1092PR00080A9.326.226e−10107-118PR00080ALCOHOL DEHYDROGENASE
SUPERFAMILY SIGNATURE
1092PR00081A10.533.106e−1031-48PR00081GLUCOSE/RIBITOL
DEHYDROGENASE FAMILY
SIGNATURE
1092PR00081B10.386.727e−11107-118PR00081GLUCOSE/RIBITOL
DEHYDROGENASE FAMILY
SIGNATURE
1092PR00081E17.543.935e−10212-229PR00081GLUCOSE/RIBITOL
DEHYDROGENASE FAMILY
SIGNATURE
1093BL00115Z3.129.074e−09157-205BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1093PR00910A2.518.889e−10203-215PR00910LUTEOVIRUS ORF6 PROTEIN
SIGNATURE
1094BL00492A11.534.724e−1816-32BL00492Clusterin proteins.
1094BL00492B10.369.053e−2840-62BL00492Clusterin proteins.
1094BL00492C8.351.000e−3866-99BL00492Clusterin proteins.
1094BL00492D13.231.000e−40100-136BL00492Clusterin proteins.
1094BL00492E12.521.000e−40142-190BL00492Clusterin proteins.
1094BL00492F16.611.000e−40232-273BL00492Clusterin proteins.
1094BL00492G13.201.000e−40299-348BL00492Clusterin proteins.
1094BL00492H16.506.870e−40427-463BL00492Clusterin proteins.
1096BL00420A20.421.000e−08248-276BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.421.000e−09779-807BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.421.000e−101043-1071BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.421.138e−10824-852BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.421.148e−10377-405BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.421.164e−11329-357BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.421.295e−10608-636BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.421.491e−111145-1173BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.421.738e−10887-915BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.421.831e−091040-1068BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.421.969e−09530-558BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.422.108e−09461-489BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.422.108e−09842-870BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.422.108e−09932-960BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.422.108e−09956-984BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.422.246e−09401-429BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.422.309e−11347-375BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.422.309e−11803-831BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.422.385e−09833-861BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.422.473e−11500-528BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.422.523e−091142-1170BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.422.662e−09130-158BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.422.770e−10674-702BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.423.077e−09395-423BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.423.215e−09133-161BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.423.215e−09467-495BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.423.455e−11551-579BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.423.618e−11908-936BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.423.631e−091073-1101BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.423.631e−09497-525BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.423.656e−10539-567BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.423.803e−10209-237BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.423.908e−09515-543BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.423.908e−09584-612BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.423.951e−10881-909BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.424.046e−09191-219BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.424.046e−09341-369BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.424.246e−101013-1041BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.424.273e−11299-327BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.424.323e−091046-1074BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.424.323e−09242-270BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.424.490e−13566-594BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.424.738e−09440-468BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.424.738e−09641-669BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.424.927e−111103-1131BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.424.984e−10707-735BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.424.984e−10878-906BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.425.154e−091166-1194BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.425.154e−09443-471BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.425.154e−09647-675BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.425.292e−09710-738BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.425.292e−09935-963BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.425.426e−10869-897BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.425.569e−09127-155BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.425.869e−10872-900BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.425.909e−11968-996BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.426.123e−091124-1152BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.426.123e−09488-516BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.426.123e−09590-618BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.426.143e−13653-681BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.426.262e−09791-819BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.426.400e−09371-399BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.426.400e−11572-600BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.426.459e−10263-291BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.426.538e−09359-387BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.426.815e−09521-549BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.427.092e−091160-1188BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.427.092e−09731-759BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.427.092e−09890-918BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.427.197e−10317-345BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.427.197e−10425-453BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.427.231e−09836-864BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.427.369e−09218-246BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.427.508e−091148-1176BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.427.508e−09 992-1020BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.427.646e−09227-255BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.427.646e−09491-519BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.427.787e−10185-213BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.036e−11722-750BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.071e−15410-438BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.082e−10206-234BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.230e−10518-546BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.338e−09812-840BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.347e−13944-972BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.377e−10284-312BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.377e−10587-615BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.477e−09542-570BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.477e−09635-663BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.525e−10773-801BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.531e−13485-513BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.615e−12605-633BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.754e−09758-786BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.892e−09230-258BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.892e−09506-534BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.428.892e−09911-939BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.429.031e−09398-426BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.429.031e−09677-705BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.429.031e−09860-888BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.429.115e−10947-975BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.429.135e−12800-828BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.429.169e−091121-1149BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.429.182e−11629-657BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.429.262e−10136-164BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.429.345e−11197-225BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.429.585e−09407-435BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.429.585e−09971-999BL00420Speract receptor repeat
proteins domain
proteins.
1096BL00420A20.429.852e−10719-747BL00420Speract receptor repeat
proteins domain
proteins.
1096BL01113A17.991.000e−081022-1048BL01113C1q domain proteins.
1096BL01113A17.991.000e−09593-619BL01113C1q domain proteins.
1096BL01113A17.991.173e−091145-1171BL01113C1q domain proteins.
1096BL01113A17.991.346e−09461-487BL01113C1q domain proteins.
1096BL01113A17.991.519e−09524-550BL01113C1q domain proteins.
1096BL01113A17.991.614e−11139-165BL01113C1q domain proteins.
1096BL01113A17.991.614e−11584-610BL01113C1q domain proteins.
1096BL01113A17.991.692e−09209-235BL01113C1q domain proteins.
1096BL01113A17.991.692e−09410-436BL01113C1q domain proteins.
1096BL01113A17.991.692e−09644-670BL01113C1q domain proteins.
1096BL01113A17.991.818e−11896-922BL01113C1q domain proteins.
1096BL01113A17.991.957e−10815-841BL01113C1q domain proteins.
1096BL01113A17.992.038e−09233-259BL01113C1q domain proteins.
1096BL01113A17.992.154e−12515-541BL01113C1q domain proteins.
1096BL01113A17.992.227e−11191-217BL01113C1q domain proteins.
1096BL01113A17.992.241e−16130-156BL01113C1q domain proteins.
1096BL01113A17.992.532e−10419-445BL01113C1q domain proteins.
1096BL01113A17.992.558e−09566-592BL01113C1q domain proteins.
1096BL01113A17.992.731e−091040-1066BL01113C1q domain proteins.
1096BL01113A17.992.731e−09365-391BL01113C1q domain proteins.
1096BL01113A17.992.846e−12716-742BL01113C1q domain proteins.
1096BL01113A17.992.846e−12806-832BL01113C1q domain proteins.
1096BL01113A17.992.904e−09521-547BL01113C1q domain proteins.
1096BL01113A17.992.915e−10965-991BL01113C1q domain proteins.
1096BL01113A17.993.045e−11218-244BL01113C1q domain proteins.
1096BL01113A17.993.077e−09 995-1021BL01113C1q domain proteins.
1096BL01113A17.993.106e−10491-517BL01113C1q domain proteins.
1096BL01113A17.993.250e−09338-364BL01113C1q domain proteins.
1096BL01113A17.993.250e−11482-508BL01113C1q domain proteins.
1096BL01113A17.993.298e−10473-499BL01113C1q domain proteins.
1096BL01113A17.993.298e−10560-586BL01113C1q domain proteins.
1096BL01113A17.993.298e−10929-955BL01113C1q domain proteins.
1096BL01113A17.993.489e−10284-310BL01113C1q domain proteins.
1096BL01113A17.993.489e−10377-403BL01113C1q domain proteins.
1096BL01113A17.993.489e−10638-664BL01113C1q domain proteins.
1096BL01113A17.993.596e−09 989-1015BL01113C1q domain proteins.
1096BL01113A17.993.659e−11911-937BL01113C1q domain proteins.
1096BL01113A17.993.681e−10242-268BL01113C1q domain proteins.
1096BL01113A17.993.769e−09124-150BL01113C1q domain proteins.
1096BL01113A17.993.769e−09467-493BL01113C1q domain proteins.
1096BL01113A17.993.769e−09917-943BL01113C1q domain proteins.
1096BL01113A17.993.769e−12197-223BL01113C1q domain proteins.
1096BL01113A17.994.064e−10773-799BL01113C1q domain proteins.
1096BL01113A17.994.068e−11569-595BL01113C1q domain proteins.
1096BL01113A17.994.115e−09878-904BL01113C1q domain proteins.
1096BL01113A17.994.162e−13548-574BL01113C1q domain proteins.
1096BL01113A17.994.288e−091031-1057BL01113C1q domain proteins.
1096BL01113A17.994.447e−10653-679BL01113C1q domain proteins.
1096BL01113A17.994.447e−10710-736BL01113C1q domain proteins.
1096BL01113A17.994.462e−09662-688BL01113C1q domain proteins.
1096BL01113A17.994.477e−11926-952BL01113C1q domain proteins.
1096BL01113A17.994.635e−09422-448BL01113C1q domain proteins.
1096BL01113A17.994.638e−10452-478BL01113C1q domain proteins.
1096BL01113A17.994.682e−11133-159BL01113C1q domain proteins.
1096BL01113A17.994.682e−11920-946BL01113C1q domain proteins.
1096BL01113A17.994.692e−12809-835BL01113C1q domain proteins.
1096BL01113A17.994.774e−15428-454BL01113C1q domain proteins.
1096BL01113A17.994.808e−09374-400BL01113C1q domain proteins.
1096BL01113A17.994.808e−09890-916BL01113C1q domain proteins.
1096BL01113A17.994.808e−17136-162BL01113C1q domain proteins.
1096BL01113A17.994.892e−13887-913BL01113C1q domain proteins.
1096BL01113A17.995.154e−12404-430BL01113C1q domain proteins.
1096BL01113A17.995.295e−111181-1207BL01113C1q domain proteins.
1096BL01113A17.995.327e−09497-523BL01113C1q domain proteins.
1096BL01113A17.995.327e−09674-700BL01113C1q domain proteins.
1096BL01113A17.995.500e−09821-847BL01113C1q domain proteins.
1096BL01113A17.995.500e−09944-970BL01113C1q domain proteins.
1096BL01113A17.995.500e−111166-1192BL01113C1q domain proteins.
1096BL01113A17.995.596e−10386-412BL01113C1q domain proteins.
1096BL01113A17.995.787e−10335-361BL01113C1q domain proteins.
1096BL01113A17.996.019e−09263-289BL01113C1q domain proteins.
1096BL01113A17.996.019e−09914-940BL01113C1q domain proteins.
1096BL01113A17.996.077e−12188-214BL01113C1q domain proteins.
1096BL01113A17.996.077e−12290-316BL01113C1q domain proteins.
1096BL01113A17.996.114e−11224-250BL01113C1q domain proteins.
1096BL01113A17.996.170e−10791-817BL01113C1q domain proteins.
1096BL01113A17.996.192e−09380-406BL01113C1q domain proteins.
1096BL01113A17.996.308e−12557-583BL01113C1q domain proteins.
1096BL01113A17.996.308e−12731-757BL01113C1q domain proteins.
1096BL01113A17.996.362e−10221-247BL01113C1q domain proteins.
1096BL01113A17.996.362e−10872-898BL01113C1q domain proteins.
1096BL01113A17.996.455e−14842-868BL01113C1q domain proteins.
1096BL01113A17.996.538e−09293-319BL01113C1q domain proteins.
1096BL01113A17.996.553e−101142-1168BL01113C1q domain proteins.
1096BL01113A17.996.745e−10575-601BL01113C1q domain proteins.
1096BL01113A17.996.769e−121046-1072BL01113C1q domain proteins.
1096BL01113A17.996.936e−10947-973BL01113C1q domain proteins.
1096BL01113A17.997.058e−09608-634BL01113C1q domain proteins.
1096BL01113A17.997.128e−10248-274BL01113C1q domain proteins.
1096BL01113A17.997.128e−10938-964BL01113C1q domain proteins.
1096BL01113A17.997.231e−12121-147BL01113C1q domain proteins.
1096BL01113A17.997.319e−10182-208BL01113C1q domain proteins.
1096BL01113A17.997.319e−10563-589BL01113C1q domain proteins.
1096BL01113A17.997.341e−11 974-1000BL01113C1q domain proteins.
1096BL01113A17.997.404e−09539-565BL01113C1q domain proteins.
1096BL01113A17.997.511e−101001-1027BL01113C1q domain proteins.
1096BL01113A17.997.511e−10206-232BL01113C1q domain proteins.
1096BL01113A17.997.511e−10851-877BL01113C1q domain proteins.
1096BL01113A17.997.545e−14239-265BL01113C1q domain proteins.
1096BL01113A17.997.545e−14299-325BL01113C1q domain proteins.
1096BL01113A17.997.577e−091175-1201BL01113C1q domain proteins.
1096BL01113A17.997.702e−10656-682BL01113C1q domain proteins.
1096BL01113A17.997.750e−091127-1153BL01113C1q domain proteins.
1096BL01113A17.997.750e−09203-229BL01113C1q domain proteins.
1096BL01113A17.997.750e−09332-358BL01113C1q domain proteins.
1096BL01113A17.997.923e−09485-511BL01113C1q domain proteins.
1096BL01113A17.997.955e−111010-1036BL01113C1q domain proteins.
1096BL01113A17.998.085e−10551-577BL01113C1q domain proteins.
1096BL01113A17.998.096e−09 998-1024BL01113C1q domain proteins.
1096BL01113A17.998.159e−111151-1177BL01113C1q domain proteins.
1096BL01113A17.998.277e−10506-532BL01113C1q domain proteins.
1096BL01113A17.998.385e−121118-1144BL01113C1q domain proteins.
1096BL01113A17.998.442e−09145-171BL01113C1q domain proteins.
1096BL01113A17.998.442e−09254-280BL01113C1q domain proteins.
1096BL01113A17.998.442e−09941-967BL01113C1q domain proteins.
1096BL01113A17.998.468e−101160-1186BL01113C1q domain proteins.
1096BL01113A17.998.568e−11695-721BL01113C1q domain proteins.
1096BL01113A17.998.615e−09215-241BL01113C1q domain proteins.
1096BL01113A17.998.615e−09650-676BL01113C1q domain proteins.
1096BL01113A17.998.615e−12647-673BL01113C1q domain proteins.
1096BL01113A17.998.660e−10683-709BL01113C1q domain proteins.
1096BL01113A17.998.660e−10758-784BL01113C1q domain proteins.
1096BL01113A17.998.773e−111121-1147BL01113C1q domain proteins.
1096BL01113A17.998.788e−09281-307BL01113C1q domain proteins.
1096BL01113A17.998.851e−10413-439BL01113C1q domain proteins.
1096BL01113A17.998.962e−09641-667BL01113C1q domain proteins.
1096BL01113A17.998.962e−09818-844BL01113C1q domain proteins.
1096BL01113A17.998.962e−09956-982BL01113C1q domain proteins.
1096BL01113A17.999.043e−101157-1183BL01113C1q domain proteins.
1096BL01113A17.999.043e−10308-334BL01113C1q domain proteins.
1096BL01113A17.999.043e−10623-649BL01113C1q domain proteins.
1096BL01113A17.999.077e−12185-211BL01113C1q domain proteins.
1096BL01113A17.999.135e−09389-415BL01113C1q domain proteins.
1096BL01113A17.999.135e−09488-514BL01113C1q domain proteins.
1096BL01113A17.999.182e−11740-766BL01113C1q domain proteins.
1096BL01113A17.999.308e−09443-469BL01113C1q domain proteins.
1096BL01113A17.999.426e−101025-1051BL01113C1q domain proteins.
1096BL01113A17.999.426e−10536-562BL01113C1q domain proteins.
1096BL01113A17.999.455e−14800-826BL01113C1q domain proteins.
1096BL01113A17.999.481e−09704-730BL01113C1q domain proteins.
1096BL01113A17.999.514e−131043-1069BL01113C1q domain proteins.
1096BL01113A17.999.591e−11476-502BL01113C1q domain proteins.
1096BL01113A17.999.617e−10194-220BL01113C1q domain proteins.
1096BL01113A17.999.617e−10395-421BL01113C1q domain proteins.
1096BL01113A17.999.617e−10770-796BL01113C1q domain proteins.
1096BL01113A17.999.654e−09200-226BL01113C1q domain proteins.
1096BL01113A17.999.654e−09230-256BL01113C1q domain proteins.
1096BL01113A17.999.757e−13127-153BL01113C1q domain proteins.
1096BL01113A17.999.757e−13142-168BL01113C1q domain proteins.
1096BL01113A17.999.809e−10722-748BL01113C1q domain proteins.
1096BL01113A17.999.827e−09545-571BL01113C1q domain proteins.
1096BL01113A17.999.827e−09692-718BL01113C1q domain proteins.
1096BL01208B15.835.950e−1384-98BL01208VWFC domain proteins.
1096DM01418A20.831.000e−401255-1302DM01418352 FIBRILLAR COLLAGEN
CARBOXYL-TERMINAL.
1096DM01418B22.511.000e−401354-1395DM01418352 FIBRILLAR COLLAGEN
CARBOXYL-TERMINAL.
1096DM01418C20.485.500e−401425-1466DM01418352 FIBRILLAR COLLAGEN
CARBOXYL-TERMINAL.
1096PR00049D0.005.271e−091181-1195PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1096PR00049D0.005.424e−091180-1194PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1096PR00049D0.006.186e−09142-156PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1096PR00049D0.008.571e−101177-1191PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1100BL01019A13.204.156e−12234-273BL01019ADP-ribosylation
factors family
proteins.
1100PR00318A7.841.600e−19 88-103PR00318ALPHA G-PROTEIN
(TRANSDUCIN) SIGNATURE
1100PR00318B14.799.000e−28221-243PR00318ALPHA G-PROTEIN
(TRANSDUCIN) SIGNATURE
1100PR000318C12.093.571e−24250-267PR00318ALPHA G-PROTEIN
(TRANSDUCIN) SIGNATURE
1100PR00318D16.281.563e−30272-300PR00318ALPHA G-PROTEIN
(TRANSDUCIN) SIGNATURE
1100PR00318E7.232.125e−13318-327PR00318ALPHA G-PROTEIN
(TRANSDUCIN) SIGNATURE
1100PR00440A9.185.645e−15 88-103PR00440G-PROTEIN ALPHA SUBUNIT
GROUP 12 SIGNATURE
1100PR00440B13.276.260e−13221-243PR00440G-PROTEIN ALPHA SUBUNIT
GROUP 12 SIGNATURE
1100PR00440C9.546.885e−18250-267PR00440G-PROTEIN ALPHA SUBUNIT
GROUP 12 SIGNATURE
1100PR00440D8.151.303e−15272-300PR00440G-PROTEIN ALPHA SUBUNIT
GROUP 12 SIGNATURE
1100PR00440E11.163.880e−10319-327PR00440G-PROTEIN ALPHA SUBUNIT
GROUP 12 SIGNATURE
1100PR00441A10.691.375e−19 88-103PR00441G-PROTEIN ALPHA SUBUNIT
GROUP I SIGNATURE
1100PR00441B16.164.000e−29221-243PR00441G-PROTEIN ALPHA SUBUNIT
GROUP I SIGNATURE
1100PR00441C14.171.409e−24250-267PR00441G-PROTEIN ALPHA SUBUNIT
GROUP I SIGNATURE
1100PR00441D14.449.250e−36272-300PR00441G-PROTEIN ALPHA SUBUNIT
GROUP I SIGNATURE
1100PR00441E8.351.214e−11319-327PR00441G-PROTEIN ALPHA SUBUNIT
GROUP I SIGNATURE
1100PR00441F11.656.850e−14331-341PR00441G-PROTEIN ALPHA SUBUNIT
GROUP I SIGNATURE
1100PR00441G11.672.543e−13347-361PR00441G-PROTEIN ALPHA SUBUNIT
GROUP I SIGNATURE
1100PR00442A6.462.385e−14 88-103PR00442G-PROTEIN ALPHA SUBUNIT
GROUP Q SIGNATURE
1100PR00442B7.171.794e−18221-244PR00442G-PROTEIN ALPHA SUBUNIT
GROUP Q SIGNATURE
1100PR00442C17.619.654e−20250-267PR00442G-PROTEIN ALPHA SUBUNIT
GROUP Q SIGNATURE
1100PR00442D9.298.071e−18272-300PR00442G-PROTEIN ALPHA SUBUNIT
GROUP Q SIGNATURE
1100PR00442E7.231.106e−11319-327PR00442G-PROTEIN ALPHA SUBUNIT
GROUP Q SIGNATURE
1100PR00443A15.168.313e−18 88-103PR00443G-PROTEIN ALPHA SUBUNIT
GROUP S SIGNATURE
1100PR00443C14.357.446e−16221-243PR00443G-PROTEIN ALPHA SUBUNIT
GROUP S SIGNATURE
1100PR00443D13.153.361e−17250-267PR00443G-PROTEIN ALPHA SUBUNIT
GROUP S SIGNATURE
1100PR00443E11.987.513e−17272-300PR00443G-PROTEIN ALPHA SUBUNIT
GROUP S SIGNATURE
1100PR00443F12.685.909e−10319-327PR00443G-PROTEIN ALPHA SUBUNIT
GROUP S SIGNATURE
1100PR00449A13.201.000e−08 87-108PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1101BL00166C18.934.600e−13453-479BL00166Enoyl-CoA
hydratase/isomerase
proteins.
1101BL00166D22.875.600e−16504-539BL00166Enoyl-CoA
hydratase/isomerase
proteins.
1101BL0059814.456.625e−16 92-113BL00598Chromo domain proteins.
1101PR00504B9.124.600e−13 86-100PR00504CHROMODOMAIN SIGNATURE
1101PR00504C11.195.592e−09101-113PR00504CHROMODOMAIN SIGNATURE
1101PR00584E4.208.000e−09126-133PR00584PROSTANOID EP3 RECEPTOR
TYPE 2 SIGNATURE
1102BL00383A13.344.150e−14926-940BL00383Tyrosine specific
protein phosphatases
proteins.
1102BL00383B7.615.000e−09951-959BL00383Tyrosine specific
protein phosphatases
proteins.
1102BL00383C10.105.091e−12981-991BL00383Tyrosine specific
protein phosphatases
proteins.
1102BL00383D11.921.000e−141055-1067BL00383Tyrosine specific
protein phosphatases
proteins.
1102BL00383D11.925.500e−091293-1305BL00383Tyrosine specific
protein phosphatases
proteins.
1102BL00383E10.351.789e−091387-1397BL00383Tyrosine specific
protein phosphatases
proteins.
1102BL00383E10.357.300e−141093-1103BL00383Tyrosine specific
protein phosphatases
proteins.
1102BL00383F15.511.439e−091425-1440BL00383Tyrosine specific
protein phosphatases
proteins.
1102BL00383F15.514.913e−141131-1146BL00383Tyrosine specific
protein phosphatases
proteins.
1102BL00740A13.878.667e−1336-48BL00740MAM domain proteins.
1102BL00740B19.765.500e−16167-187BL00740MAM domain proteins.
1102BL00740C15.939.000e−11681-691BL00740MAM domain proteins.
1102BL00790H13.423.769e−09498-523BL00790Receptor tyrosine
kinase class V
proteins.
1102BL00790I20.012.607e−09552-582BL00790Receptor tyrosine
kinase class V
proteins.
1102PR00014C15.444.913e−09331-349PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1102PR00014C15.449.000e−11541-559PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1102PR00014D12.049.400e−11559-573PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1102PR00020A18.171.000e−1734-52PR00020MAM DOMAIN SIGNATURE
1102PR00020B15.524.971e−1468-84PR00020MAM DOMAIN SIGNATURE
1102PR00020C13.663.483e−13 95-106PR00020MAM DOMAIN SIGNATURE
1102PR00020D12.702.543e−15147-161PR00020MAM DOMAIN SIGNATURE
1102PR00020E8.646.586e−13165-178PR00020MAM DOMAIN SIGNATURE
1102PR00700B16.804.162e−161257-1277PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1102PR00700B16.806.400e−23968-988PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1102PR00700C13.173.077e−191051-1068PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1102PR00700D12.477.136e−131384-1402PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1102PR00700D12.477.158e−201090-1108PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1102PR00700E17.579.550e−131121-1136PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1102PR00700F11.186.824e−131137-1147PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1104PF0085513.751.000e−20119-135PF00855PWWP domain proteins.
1105BL50062B12.921.290e−12280-290BL50062BCL2-like apoptosis
inhibitors (spans part
of BH3, BH1 and BH.
1105BL50062C6.668.676e−09325-333BL50062BCL2-like apoptosis
inhibitors (spans part
of BH3, BH1 and BH.
1106BL00216B27.645.765e−35123-172BL00216Sugar transport
proteins.
1106PR00171A10.008.615e−1324-34PR00171SUGAR TRANSPORTER
SIGNATURE
1106PR00171B14.734.789e−17124-143PR00171SUGAR TRANSPORTER
SIGNATURE
1106PR00171C10.973.143e−13283-293PR00171SUGAR TRANSPORTER
SIGNATURE
1106PR00171D12.765.500e−19370-391PR00171SUGAR TRANSPORTER
SIGNATURE
1106PR00171E14.878.500e−13393-405PR00171SUGAR TRANSPORTER
SIGNATURE
1106PR00172A9.829.182e−26273-294PR00172GLUCOSE TRANSPORTER
SIGNATURE
1106PR00172B8.421.000e−23308-329PR00172GLUCOSE TRANSPORTER
SIGNATURE
1106PR00172C9.517.828e−19339-359PR00172GLUCOSE TRANSPORTER
SIGNATURE
1106PR00172D9.131.000e−25370-393PR00172GLUCOSE TRANSPORTER
SIGNATURE
1106PR00172E8.292.895e−21403-421PR00172GLUCOSE TRANSPORTER
SIGNATURE
1106PR00172F8.477.188e−20433-453PR00172GLUCOSE TRANSPORTER
SIGNATURE
1107PR00704A14.689.069e−2014-37PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1107PR00704B17.942.636e−2254-76PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1107PR00704C11.884.000e−1678-94PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1107PR00704D11.052.000e−30120-145PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1107PR00704E12.555.886e−25150-173PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1107PR00704F13.618.364e−25175-202PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1107PR00704G13.877.667e−24322-343PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1107PR00704H13.383.676e−19373-390PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1107PR00704I9.528.941e−26464-492PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1108BL00383E10.359.780e−12402-412BL00383Tyrosine specific
protein phosphatases
proteins.
1108BL00383F15.519.341e−09239-254BL00383Tyrosine specific
protein phosphatases
proteins.
1108PR00716C17.655.011e−09147-167PR00716M-PHASE INDUCER
PHOSPHATASE SIGNATURE
1112BL00657A19.398.091e−30109-150BL00657Fork head domain
proteins.
1112BL00657B22.277.750e−26157-199BL00657Fork head domain
proteins.
1112PR00053A8.868.050e−09109-122PR00053FORK HEAD DOMAIN
SIGNATURE
1112PR00053B13.707.698e−13130-147PR00053FORK HEAD DOMAIN
SIGNATURE
1112PR00053C12.802.125e−19158-175PR00053FORK HEAD DOMAIN
SIGNATURE
1113BL00484B9.043.400e−12189-202BL00484Thyroglobulin type-1
repeat proteins
proteins.
1113BL00484C17.019.206e−12208-222BL00484Thyroglobulin type-1
repeat proteins
proteins.
1117BL00222A11.345.125e−09 92-102BL00222Insulin-like growth
factor binding
proteins.
1117BL00222B11.091.375e−16111-126BL00222Insulin-like growth
factor binding
proteins.
1117BL00222C22.971.667e−26261-288BL00222Insulin-like growth
factor binding
proteins.
1117BL00484B9.043.118e−17262-275BL00484Thyroglobulin type-1
repeat proteins
proteins.
1117BL00484C17.014.536e−13286-300BL00484Thyroglobulin type-1
repeat proteins
proteins.
1119BL00022B7.547.750e−10203-209BL00022EGF-like domain
proteins.
1119BL01187A9.982.714e−10175-186BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1119BL01187A9.984.750e−09216-227BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1119BL01187A9.984.750e−0946-57BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1119BL01187B12.043.000e−12272-287BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1119BL01187B12.045.304e−13194-209BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1119BL01187B12.045.500e−14232-247BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1119BL01187B12.049.400e−11313-328BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1119PD02283C17.548.988e−0958-85PD02283PROTEIN SPORULATION
REPEAT PRECU.
1119PR00010C11.161.273e−10237-247PR00010TYPE II EGF-LIKE
SIGNATURE
1119PR00010C11.164.667e−11199-209PR00010TYPE II EGF-LIKE
SIGNATURE
1119PR00907B11.296.260e−10309-325PR00907THROMBOMODULIN
SIGNATURE
1119PR00907G11.633.676e−09194-220PR00907THROMBOMODULIN
SIGNATURE
1119PR00907G11.637.368e−10232-258PR00907THROMBOMODULIN
SIGNATURE
1120BL50017B17.605.263e−114112-4127BL50017Death domain proteins
profile.
1120DM00784B17.876.311e−093961-3985DM00784APILLOMAVIRUS E4
PROTEIN.
1120DM00784B17.877.197e−093964-3988DM00784APILLOMAVIRUS E4
PROTEIN.
1120DM00784B17.879.705e−093968-3992DM00784APILLOMAVIRUS E4
PROTEIN.
1120PD00078B13.146.478e−09701-713PD00078REPEAT PROTEIN ANK
NUCLEAR ANKYR.
1120PD01364B13.942.421e−093974-3989PD01364MUCIN GLYCOPROTEIN
PRECURSOR MEM.
1120PD01364B13.943.368e−093969-3984PD01364MUCIN GLYCOPROTEIN
PRECURSOR MEM.
1120PD01364B13.946.684e−093967-3982PD01364MUCIN GLYCOPROTEIN
PRECURSOR MEM.
1120PD01364B13.948.364e−103970-3985PD01364MUCIN GLYCOPROTEIN
PRECURSOR MEM.
1120PF00023A16.031.000e−09118-133PF00023Ank repeat proteins.
1120PF00023A16.032.875e−10 85-100PF00023Ank repeat proteins.
1120PF00023A16.033.000e−12477-492PF00023Ank repeat proteins.
1120PF00023A16.034.214e−09576-591PF00023Ank repeat proteins.
1120PF00023A16.034.375e−10444-459PF00023Ank repeat proteins.
1120PF00023A16.036.143e−09279-294PF00023Ank repeat proteins.
1120PF00023A16.037.000e−10378-393PF00023Ank repeat proteins.
1120PF00023A16.037.000e−11675-690PF00023Ank repeat proteins.
1120PF00023A16.039.679e−09312-327PF00023Ank repeat proteins.
1120PF00023B14.205.000e−10704-713PF00023Ank repeat proteins.
1120PF00023B14.205.500e−09572-581PF00023Ank repeat proteins.
1120PF00023B14.208.500e−10407-416PF00023Ank repeat proteins.
1120PF00023B14.208.773e−09605-614PF00023Ank repeat proteins.
1120PF00023B14.209.000e−10242-251PF00023Ank repeat proteins.
1120PF00023B14.209.182e−09770-779PF00023Ank repeat proteins.
1120PF00791A27.851.000e−40168-222PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.491.000e−40279-333PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.491.205e−14118-172PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.491.692e−13151-205PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.492.367e−17411-465PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.493.368e−12 85-139PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.494.221e−12213-267PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.494.462e−13609-663PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.494.987e−17477-531PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.495.500e−14543-597PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.495.500e−16246-300PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.496.637e−13345-399PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.496.874e−12708-762PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.496.927e−16741-795PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.496.932e−14642-696PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.497.136e−14378-432PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.497.442e−12444-498PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.497.459e−15312-366PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.497.835e−17510-564PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.498.354e−16675-729PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791B28.498.364e−14576-630PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.981.000e−10132-170PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.981.000e−10326-364PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.981.818e−12557-595PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.981.882e−09 99-137PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.982.432e−12392-430PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.983.311e−16623-661PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.983.961e−15227-265PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.985.147e−09491-529PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.986.318e−12689-727PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.986.747e−13260-298PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.986.778e−14722-760PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.987.163e−11293-331PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.987.216e−10359-397PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.987.239e−12755-793PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.987.265e−09165-203PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.987.706e−26590-628PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.988.826e−11524-562PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791C20.989.536e−10425-463PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791D20.371.675e−361110-1152PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791E25.761.000e−401178-1230PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791F18.252.313e−191399-1423PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1120PF00791G12.162.887e−111436-1451PF00791Domain present in ZO-1
and Unc5-like netrin
receptors.
1121BL00107A18.394.938e−21459-489BL00107Protein kinases ATP-
binding region
proteins.
1121BL00239B25.158.967e−19394-441BL00239Receptor tyrosine
kinase class II
proteins.
1121BL00239C18.759.169e−11446-468BL00239Receptor tyrosine
kinase class II
proteins.
1121BL00239E17.141.802e−10516-565BL00239Receptor tyrosine
kinase class II
proteins.
1121BL00239F28.156.082e−09571-615BL00239Receptor tyrosine
kinase class II
proteins.
1121BL00240E11.563.813e−11445-482BL00240Receptor tyrosine
kinase class III
proteins.
1121BL00240F17.743.172e−09515-562BL00240Receptor tyrosine
kinase class III
proteins.
1121BL00478B14.791.643e−1351-65BL00478LIM domain proteins.
1121BL00478B14.797.800e−11109-123BL00478LIM domain proteins.
1121BL00790M8.745.382e−13450-471BL00790Receptor tyrosine
kinase class V
proteins.
1121BL50001B17.401.000e−08456-476BL50001Src homology 2 (SH2)
domain proteins
profile.
1121PD002899.978.200e−11219-232PD00289PROTEIN SH3 DOMAIN
REPEAT PRESYNA.
1121PF0059513.403.000e−11216-226PF00595PDZ domain proteins
(Also known as DHR or
GLGF).
1121PR00109A15.008.839e−10423-436PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1121PR00109B12.277.511e−13459-477PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1121PR00109E14.417.894e−10590-612PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1123BL0028024.613.172e−3336-79BL00280Pancreatic trypsin
inhibitor (Kunitz)
family proteins.
1123PR00759A14.513.880e−1026-40PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1123PR00759B11.266.400e−1354-64PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1123PR00759C14.152.364e−1264-79PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1125PR00790I14.971.818e−32 77-100PR00790PEPTIDYL-GLYCINE ALPHA-
AMIDATING MONOOXYGENASE
SIGNATURE
1126DM004067.732.000e−09637-649DM00406GLIADIN.
1126PD01234A11.061.450e−09638-648PD01234PROTEIN NUCLEAR
BROMODOMAIN TRANS.
1126PF00806B11.324.176e−12980-989PF00806Pumilio-family RNA
binding domain proteins
(aka PUM-HD, Pumilio
homol.
1126PF00806C7.812.452e−101131-1139PF00806Pumilio-family RNA
binding domain proteins
(aka PUM-HD, Pumilio
1126PF00806C7.815.263e−111052-1060PF00806Pumilio-family RNA
binding domain proteins
(aka PUM-HD, Pumilio
homol.
1126PF00806C7.817.632e−09908-916PF00806Pumilio-family RNA
binding domain proteins
(aka PUM-HD, Pumilio
homol.
1126PR00308C3.839.649e−09490-499PR00308TYPE I ANTIFREEZE
PROTEIN SIGNATURE
1130PD00301B5.495.154e−09137-147PD00301PROTEIN REPEAT MUSCLE
CALCIUM-BI.
1130PR00796I8.961.517e−09 98-123PR00796VIRAL SPIKE
GLYCOPROTEIN PRECURSOR
SIGNATURE
1132BL000187.418.435e−0928-40BL00018EF-hand calcium-binding
domain proteins.
1133BL0020313.947.415e−102460-2505BL00203Vertebrate
metallothioneins
proteins.
1133BL01185C15.864.506e−102043-2081BL01185C-terminal cystine knot
proteins.
1133BL01185C15.869.065e−10960-998BL01185C-terminal cystine knot
proteins.
1133BL01185D23.458.800e−162860-2912BL01185C-terminal cystine knot
proteins.
1133BL01208B15.834.938e−10775-789BL01208VWFC domain proteins.
1133PD02576A27.601.000e−40932-980PD02576PRECURSOR GLYCOPROTEIN
SIGNAL CELL.
1133PD02576A27.604.857e−27453-501PD02576PRECURSOR GLYCOPROTEIN
SIGNAL CELL.
1133PD02576A27.607.882e−102534-2582PD02576PRECURSOR GLYCOPROTEIN
SIGNAL CELL.
1133PD02576B25.431.667e−221495-1522PD02576PRECURSOR GLYCOPROTEIN
SIGNAL CELL.
1133PF00094A11.094.333e−13476-485PF00094von Willebrand factor
type D domain proteins.
1133PF00094B10.433.647e−23624-641PF00094von Willebrand factor
type D domain proteins.
1133PF00094B10.438.440e−111096-1113PF00094von Willebrand factor
type D domain proteins.
1133PF00094B10.439.571e−14262-279PF00094von Willebrand factor
type D domain proteins.
1133PF00094C12.885.500e−15835-844PF00094von Willebrand factor
type D domain proteins.
1133PR00453A12.794.656e−131382-1399PR00453VON WILLEBRAND FACTOR
TYPE A DOMAIN SIGNATURE
1133PR00453A12.795.696e−101603-1620PR00453VON WILLEBRAND FACTOR
TYPE A DOMAIN SIGNATURE
1133PR00453B14.655.135e−111642-1656PR00453VON WILLEBRAND FACTOR
TYPE A DOMAIN SIGNATURE
1134PR00421B11.407.600e−09 94-103PR00421THIOREDOXIN FAMILY
SIGNATURE
1135DM0021519.435.729e−0937-69DM00215PROLINE-RICH PROTEIN 3.
1137BL00107A18.391.000e−20197-227BL00107Protein kinases ATP-
binding region
proteins.
1137BL00107B13.312.286e−10268-283BL00107Protein kinases ATP-
binding region
proteins.
1137BL00239B25.154.097e−09124-171BL00239Receptor tyrosine
kinase class II
proteins.
1137BL00240E11.565.371e−09183-220BL00240Receptor tyrosine
kinase class III
proteins.
1137BL00479C12.013.500e−09246-258BL00479Phorbol esters/
diacylglycerol binding
domain proteins.
1137PR00109B12.273.471e−12197-215PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1137PR00109D17.043.441e−10269-291PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1138BL00297A17.582.895e−35 86-122BL00297Heat shock hsp70
proteins family
proteins.
1138BL00297B22.911.000e−40126-174BL00297Heat shock hsp70
proteins family
proteins.
1138BL00297C9.511.000e−40211-262BL00297Heat shock hsp70
proteins family
proteins.
1138BL00297D11.953.813e−40270-309BL00297Heat shock hsp70
proteins family
proteins.
1138BL00297E18.566.478e−32371-414BL00297Heat shock hsp70
proteins family
proteins.
1138BL00297F11.844.750e−25434-461BL00297Heat shock hsp70
proteins family
proteins.
1138BL00297G21.871.000e−40464-518BL00297Heat shock hsp70
proteins family
proteins.
1138BL00297H15.461.000e−40527-580BL00297Heat shock hsp70
proteins family
proteins.
1138BL00933A17.507.857e−09 84-107BL00933FGGY family of
carbohydrate kinases
proteins.
1138PR00301A14.843.455e−1584-97PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1138PR00301B15.367.000e−15112-124PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1138PR00301C8.623.903e−09135-143PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1138PR00301D15.515.500e−27219-239PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1138PR00301E8.111.900e−11278-288PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1138PR00301F13.984.240e−18410-426PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1138PR00301G13.789.609e−22441-461PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1138PR00301H8.812.688e−22464-483PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1138PR00301I12.767.500e−21545-561PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1139BL00960A10.985.304e−1264-75BL00960BTG1 family proteins.
1139BL00960B24.471.000e−40 84-128BL00960BTG1 family proteins.
1139BL00960C12.683.647e−26148-169BL00960BTG1 family proteins.
1139PD01234B15.539.679e−0936-53PD01234PROTEIN NUCLEAR
BROMODOMAIN TRANS.
1139PR00310A11.177.000e−2766-90PR00310ANTI-PROLIFERATIVE
PROTEIN BTG1 FAMILY
SIGNATURE
1139PR00310B10.594.000e−39 91-120PR00310ANTI-PROLIFERATIVE
PROTEIN BTG1 FAMILY
SIGNATURE
1139PR00310C12.745.286e−35121-150PR00310ANTI-PROLIFERATIVE
PROTEIN BTG1 FAMILY
SIGNATURE
1139PR00310D9.101.540e−37151-180PR00310ANTI-PROLIFERATIVE
PROTEIN BTG1 FAMILY
SIGNATURE
1139PR00310E13.586.914e−24197-216PR00310ANTI-PROLIFERATIVE
PROTIN BTG1 FAMILY
SIGNATURE
1141BL00547A19.157.900e−22 89-115BL00547Transglutaminases
proteins.
1141BL00547B29.051.000e−40209-259BL00547Transglutaminases
proteins.
1141BL00547C20.722.029e−29281-318BL00547Transglutaminases
proteins.
1141BL00547D20.721.000e−40338-382BL00547Transglutaminases
proteins.
1141BL00547E17.364.667e−37396-430BL00547Transglutaminases
proteins.
1141BL00547F20.849.700e−28440-471BL00547Transglutaminases
proteins.
1141BL00547G17.294.971e−31489-526BL00547Transglutaminases
proteins.
1141BL00547H14.369.471e−16681-701BL00547Transglutaminases
proteins.
1141PR00445A9.206.824e−09356-363PR00445HUPF/HYPC HYDROGENASE
EXPRESSION/SYNTHESIS
FAMILY SIGNATURE
1143BL00224B16.949.673e−09589-641BL00224Clathrin light chain
proteins.
1143BL0068613.916.581e−09820-868BL00686CBF-B/NF-YA subunit
proteins.
1143PF00992A16.671.474e−09819-853PF00992Troponin.
1143PF00992A16.672.184e−09798-832PF00992Troponin.
1143PF00992A16.679.463e−11812-846PF00992Troponin.
1143PF00992A16.679.463e−11853-887PF00992Troponin.
1143PF01140D15.544.035e−09797-831PF01140Matrix protein (MA),
p15.
1143PF01140D15.546.850e−10811-845PF01140Matrix protein (MA),
p15.
1145BL00211A12.232.350e−09122-133BL00211ABC transporters family
proteins.
1145BL00617A25.537.000e−10105-147BL00617RecF protein.
1146BL0071012.983.880e−16182-196BL00710Phosphoglucomutase and
phosphomannomutase
phosphoserine signa.
1146PR00509A14.011.964e−17181-195PR00509PHOSPHOGLUCOMUTASE/
PHOSPHOMANNOMUTASE FAMILY
SIGNATURE
1146PR00509B15.057.353e−19288-307PR00509PHOSPHOGLUCOMUTASE/
PHOSPHOMANNOMUTASE FAMILY
SIGNATURE
1146PR00509C9.788.875e−16324-337PR00509PHOSPHOGLUCOMUTASE/
PHOSPHOMANNOMUTASE FAMILY
SIGNATURE
1146PR00509D9.213.000e−19352-367PR00509PHOSPHOGLUCOMUTASE/
PHOSPHOMANNOMUTASE FAMILY
SIGNATURE
1147BL00415B9.919.206e−09 5-40BL00415Synapsins proteins.
1150PR00676D10.159.536e−0947-62PR00676MASPIN SIGNATURE
1152BL01123D9.686.651e−11217-232BL01123Thermonuclease family
proteins.
1154BL00226A12.776.500e−16133-147BL00226Intermediate filaments
proteins.
1154BL00226B23.861.000e−40229-276BL00226Intermediate filaments
proteins.
1154BL00226B23.863.160e−11180-227BL00226Intermediate filaments
proteins.
1154BL00226C13.233.700e−25294-324BL00226Intermediate filaments
proteins.
1154BL00226D19.101.000e−40395-441BL00226Intermediate filaments
proteins.
1154BL01160B19.541.763e−09180-233BL01160Kinesin light chain
repeat proteins.
1154BL01312I22.761.758e−09162-210BL01312Protein secA proteins.
1155BL00022B7.541.000e−091154-1160BL00022EGF-like domain
proteins.
1155BL00022B7.543.250e−101558-1564BL00022EGF-like domain
proteins.
1155BL00240B24.708.660e−093622-3645BL00240Receptor tyrosine
kinase class III
proteins.
1155BL00243H17.539.645e−094180-4205BL00243Integrins beta chain
cysteine-rich domain
proteins.
1155BL0056216.215.814e−094127-4157BL00562Cellulose-binding
domain proteins fungal
type.
1155BL012099.312.174e−11370-382BL01209LDL-receptor class A
(LDLRA) domain
proteins.
1155BL012099.314.808e−10414-426BL01209LDL-receptor class A
(LDLRA) domain
proteins.
1155BL012099.316.304e−09245-257BL01209LDL-receptor class A
(LDLRA) domain
proteins.
1155BL012099.319.053e−15330-342BL01209LDL-receptor class A
(LDLRA) domain
proteins.
1155BL0124811.023.829e−121206-1218BL01248Laminin-type EGF-like
(LE) domain proteins.
1155BL0124811.024.724e−13811-823BL01248Laminin-type EGF-like
(LE) domain proteins.
1155BL0124811.028.650e−111610-1622BL01248Laminin-type EGF-like
(LE) domain proteins.
1155DM000606.923.700e−101687-1696DM00060338 kw NEUREXIN ALPHA
III CYSTEINE.
1155DM000606.927.000e−11888-897DM00060338 kw NEUREXIN ALPHA
III CYSTEINE.
1155DM0017913.972.421e−103386-3395DM00179w KINASE ALPHA ADHESION
T-CELL.
1155PD00320A14.493.455e−111586-1599PD00320LAMININ CHAIN EGF-LIKE
DOMAIN P.
1155PD00919B9.478.015e−101662-1676PD00919CALCIUM-BINDING
PRECURSOR SIGNAL R.
1155PD01270A17.223.903e−09431-470PD01270RECEPTOR FC
IMMUNOGLOBULIN AFFIN.
1155PD02870B18.833.968e−092516-2548PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1155PD02870B18.836.300e−101853-1885PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1155PD02870B18.836.400e−103198-3230PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1155PD02870B18.836.553e−092130-2162PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1155PD02870B18.836.649e−092420-2452PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1155PD02870B18.837.798e−091759-1791PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1155PD02870B18.839.000e−102613-2645PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1155PD02870B18.839.809e−092709-2741PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1155PD02870D15.741.383e−091853-1887PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1155PR00010A11.791.000e−084132-4143PR00010TYPE II EGF-LIKE
SIGNATURE
1155PR00010C11.169.333e−113893-3903PR00010TYPE II EGF-LIKE
SIGNATURE
1155PR00011A14.069.384e−091314-1332PR00011TYPE III EGF-LIKE
SIGNATURE
1155PR00011B13.086.055e−091314-1332PR00011TYPE III EGF-LIKE
SIGNATURE
1155PR00011C24.258.000e−09920-948PR00011TYPE III EGF-LIKE
SIGNATURE
1155PR00011C24.259.518e−111321-1349PR00011TYPE III EGF-LIKE
SIGNATURE
1155PR00011D14.031.000e−111314-1332PR00011TYPE III EGF-LIKE
SIGNATURE
1155PR00011D14.039.169e−104185-4203PR00011TYPE III EGF-LIKE
SIGNATURE
1155PR00261A11.024.296e−12405-426PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261A11.025.895e−17321-342PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261A11.028.676e−13236-257PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261A11.028.984e−15361-382PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261B14.122.356e−12361-382PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261B14.122.588e−14405-426PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261B14.125.500e−17321-342PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261B14.127.662e−11236-257PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261C11.372.826e−13361-382PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261C11.376.373e−14405-426PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261C11.378.500e−20321-342PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261C11.379.014e−12236-257PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261D12.471.305e−16321-342PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261D12.475.000e−15361-382PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261D12.478.734e−14236-257PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261D12.479.859e−14405-426PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261E11.083.727e−12361-382PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261E11.086.906e−13321-342PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261E11.087.171e−11236-257PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261E11.087.545e−12405-426PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261F11.575.355e−14236-257PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261F11.576.280e−10361-382PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261F11.577.589e−16321-342PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00261F11.579.603e−12405-426PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1155PR00764B13.565.091e−10356-376PR00764COMPLEMENT C9 SIGNATURE
1155PR00764B13.565.388e−09316-336PR00764COMPLEMENT C9 SIGNATURE
1158BL00107A18.391.750e−26324-354BL00107Protein kinases ATP-
binding region
proteins.
1158BL00107B13.315.500e−11389-404BL00107Protein kinases ATP-
binding region
proteins.
1158BL00479C12.013.571e−11368-380BL00479Phorbol esters/
diacylglycerol binding
domain proteins.
1158PF00564B24.748.329e−13275-325PF00564Octicosapeptide repeat
proteins.
1158PR00109B12.271.882e−12324-342PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1163PD00247C22.112.125e−0970-97PD00247POLYPROTEIN COAT
PROTEIN TRANSMEMBRANE
PRECURSOR.
1163PR00049D0.002.786e−1041-55PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1163PR00049D0.004.356e−0942-56PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1163PR00221H12.827.614e−09372-385PR00221CAULIMOVIRUS COAT
PROTEIN SIGNATURE
1164BL00649B20.682.966e−10484-529BL00649G-protein coupled
receptors family 2
proteins.
1164BL00649C17.825.255e−13542-567BL00649G-protein coupled
receptors family 2
proteins.
1164BL00649E15.341.000e−08624-653BL00649G-protein coupled
receptors family 2
proteins.
1164BL00649G13.525.208e−09706-731BL00649G-protein coupled
receptors family 2
proteins.
1164BL01187A9.981.000e−10137-148BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1164BL01187B12.041.529e−15105-120BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1164BL01187B12.046.250e−17156-171BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1164PR00010C11.167.214e−09110-120PR00010TYPE II EGF-LIKE
SIGNATURE
1164PR00249C17.085.708e−10544-567PR00249SECRETIN-LIKE GPCR
SUPERFAMILY SIGNATURE
1164PR00249D13.097.429e−09582-607PR00249SECRETIN-LIKE GPCR
SUPERFAMILY SIGNATURE
1165BL00216B27.645.000e−34147-196BL00216Sugar transport
proteins.
1165PR00171A10.001.429e−1148-58PR00171SUGAR TRANSPORTER
SIGNATURE
1165PR00171B14.733.813e−18148-167PR00171SUGAR TRANSPORTER
SIGNATURE
1165PR00171C10.973.143e−13307-317PR00171SUGAR TRANSPORTER
SIGNATURE
1165PR00171D12.767.750e−20394-415PR00171SUGAR TRANSPORTER
SIGNATURE
1165PR00171E14.872.800e−11417-429PR00171SUGAR TRANSPORTER
SIGNATURE
1165PR00172A9.825.091e−26297-318PR00172GLUCOSE TRANSPORTER
SIGNATURE
1165PR00172B8.429.500e−24332-353PR00172GLUCOSE TRANSPORTER
SIGNATURE
1165PR00172C9.515.000e−22363-383PR00172GLUCOSE TRANSPORTER
SIGNATURE
1165PR00172D9.136.824e−28394-417PR00172GLUCOSE TRANSPORTER
SIGNATURE
1165PR00172E8.292.500e−23427-445PR00172GLUCOSE TRANSPORTER
SIGNATURE
1165PR00172F8.477.750e−24457-477PR00172GLUCOSE TRANSPORTER
SIGNATURE
1167PD00301A10.241.000e−08277-287PD00301PROTEIN REPEAT MUSCLE
CALCIUM-BI.
1168BL00218D21.497.324e−11274-318BL00218Amino acid permeases
proteins.
1168BL00218E23.303.475e−09355-394BL00218Amino acid permeases
proteins.
1170PD00301A10.246.400e−0973-83PD00301PROTEIN REPEAT MUSCLE
CALCIUM-BI.
1170PR00049D0.008.627e−09175-189PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1172BL00453A15.571.000e−1656-70BL00453FKBP-type peptidyl-
prolyl cis-trans
isomerase proteins.
1172BL00453B23.867.231e−26 81-114BL00453FKBP-type peptidyl-
prolyl cis-trans
isomerase proteins.
1172BL00453C9.724.214e−13122-134BL00453FKBP-type peptidyl-
prolyl cis-trans
isomerase proteins.
1176BL00136A14.351.720e−11177-189BL00136Serine proteases,
subtilase family,
aspartic acid proteins.
1176BL00136B9.632.500e−12218-230BL00136Serine proteases,
subtilase family,
aspartic acid proteins.
1176BL00136C8.529.609e−11392-402BL00136Serine proteases,
subtilase family,
aspartic acid proteins.
1176PR00723A13.375.200e−17170-189PR00723SUBTILISIN SERINE
PROTEASE FAMILY (S8)
SIGNATURE
1176PR00723B11.225.050e−13216-229PR00723SUBTILISIN SERINE
PROTEASE FAMILY (S8)
SIGNATURE
1176PR00723C10.642.929e−13391-407PR00723SUBTILISIN SERINE
PROTEASE FAMILY (S8)
SIGNATURE
1182BL00420A20.421.138e−09505-533BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.421.148e−101129-1157BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.421.173e−121564-1592BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.421.554e−091069-1097BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.421.554e−09928-956BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.421.692e−091507-1535BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.421.692e−091558-1586BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.421.738e−101087-1115BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.421.918e−131378-1406BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.421.969e−091423-1451BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.422.328e−101252-1280BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.422.328e−101297-1325BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.422.385e−09655-683BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.422.385e−121294-1322BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.422.475e−101486-1514BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.422.523e−091126-1154BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.422.623e−101057-1085BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.422.662e−09673-701BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.422.918e−10754-782BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.423.213e−101420-1448BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.423.492e−091009-1037BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.423.631e−09670-698BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.423.769e−091459-1487BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.423.945e−11922-950BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.423.951e−101579-1607BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.424.046e−091339-1367BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.424.246e−101555-1583BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.424.635e−12787-815BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.424.689e−10871-899BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.424.836e−10820-848BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.424.984e−101489-1517BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.424.984e−10796-824BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.425.154e−12817-845BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.425.292e−09838-866BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.425.431e−091183-1211BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.425.569e−091093-1121BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.425.574e−10724-752BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.425.574e−10751-779BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.425.721e−101567-1595BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.425.745e−11 994-1022BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.425.846e−12 991-1019BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.425.869e−101372-1400BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.425.985e−091012-1040BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.426.459e−101045-1073BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.426.607e−10805-833BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.426.677e−09958-986BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.426.815e−091369-1397BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.426.815e−091471-1499BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.426.815e−09895-923BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.426.885e−121321-1349BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.426.954e−091483-1511BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.427.049e−101180-1208BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.427.049e−10847-875BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.427.055e−111504-1532BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.427.218e−111315-1343BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.427.231e−091285-1313BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.427.231e−09850-878BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.427.245e−131099-1127BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.427.369e−091162-1190BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.427.369e−09634-662BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.427.429e−131249-1277BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.427.492e−10721-749BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.427.785e−091048-1076BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.427.785e−09748-776BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.427.934e−10904-932BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.428.062e−091171-1199BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.428.338e−091522-1550BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.428.377e−101132-1160BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.428.615e−091117-1145BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.428.615e−091306-1334BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.428.672e−101270-1298BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.428.691e−111375-1403BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.428.754e−09529-557BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.428.967e−101492-1520BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.031e−091156-1184BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.031e−09931-959BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.115e−10781-809BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.115e−10910-938BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.169e−09925-953BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.182e−111414-1442BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.262e−101411-1439BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.446e−091402-1430BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.449e−131318-1346BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.585e−091123-1151BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.585e−09637-665BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.705e−10919-947BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.723e−091477-1505BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.852e−10526-554BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00420A20.429.862e−09649-677BL00420Speract receptor repeat
proteins domain
proteins.
1182BL00604F5.967.020e−091433-1477BL00604Synaptophysin/
synaptoporin proteins.
1182BL01113A17.991.000e−091123-1149BL01113c1q domain proteins.
1182BL01113A17.991.000e−091405-1431BL01113c1q domain proteins.
1182BL01113A17.991.000e−101396-1422BL01113C1q domain proteins.
1182BL01113A17.991.000e−10514-540BL01113c1q domain proteins.
1182BL01113A17.991.191e−10730-756BL01113c1q domain proteins.
1182BL01113A17.991.231e−121492-1518BL01113c1q domain proteins.
1182BL01113A17.991.243e−131177-1203BL01113c1q domain proteins.
1182BL01113A17.991.519e−09886-912BL01113c1q domain proteins.
1182BL01113A17.991.545e−141138-1164BL01113c1q domain proteins.
1182BL01113A17.991.614e−11640-666BL01113c1q domain proteins.
1182BL01113A17.991.614e−11805-831BL01113c1q domain proteins.
1182BL01113A17.991.614e−11 985-1011BL01113c1q domain proteins.
1182BL01113A17.991.818e−11751-777BL01113c1q domain proteins.
1182BL01113A17.991.865e−09523-549BL01113c1q domain proteins.
1182BL01113A17.991.865e−09 979-1005BL01113c1q domain proteins.
1182BL01113A17.991.923e−121387-1413BL01113c1q domain proteins.
1182BL01113A17.991.957e−10535-561BL01113c1q domain proteins.
1182BL01113A17.991.957e−10655-681BL01113c1q domain proteins.
1182BL01113A17.992.023e−11715-741BL01113c1q domain proteins.
1182BL01113A17.992.038e−09718-744BL01113c1q domain proteins.
1182BL01113A17.992.216e−131372-1398BL01113c1q domain proteins.
1182BL01113A17.992.385e−091450-1476BL01113c1q domain proteins.
1182BL01113A17.992.452e−15673-699BL01113c1q domain proteins.
1182BL01113A17.992.459e−131225-1251BL01113c1q domain proteins.
1182BL01113A17.992.532e−101084-1110BL01113c1q domain proteins.
1182BL01113A17.992.532e−101468-1494BL01113c1q domain proteins.
1182BL01113A17.992.532e−10754-780BL01113c1q domain proteins.
1182BL01113A17.992.558e−09712-738BL01113c1q domain proteins.
1182BL01113A17.992.558e−09811-837BL01113c1q domain proteins.
1182BL01113A17.992.636e−111048-1074BL01113c1q domain proteins.
1182BL01113A17.992.723e−101561-1587BL01113c1q domain proteins.
1182BL01113A17.992.731e−091108-1134BL01113c1q domain proteins.
1182BL01113A17.992.915e−101081-1107BL01113c1q domain proteins.
1182BL01113A17.993.045e−11727-753BL01113c1q domain proteins.
1182BL01113A17.993.298e−101585-1611BL01113c1q domain proteins.
1182BL01113A17.993.298e−101594-1620BL01113c1q domain proteins.
1182BL01113A17.993.432e−13787-813BL01113c1q domain proteins.
1182BL01113A17.993.455e−11922-948BL01113c1q domain proteins.
1182BL01113A17.993.455e−141555-1581BL01113c1q domain proteins.
1182BL01113A17.993.489e−10688-714BL01113c1q domain proteins.
1182BL01113A17.993.596e−091411-1437BL01113c1q domain proteins.
1182BL01113A17.993.596e−09685-711BL01113c1q domain proteins.
1182BL01113A17.993.596e−09739-765BL01113c1q domain proteins.
1182BL01113A17.993.769e−091117-1143BL01113c1q domain proteins.
1182BL01113A17.993.769e−09517-543BL01113C1q domain proteins.
1182BL01113A17.993.769e−09736-762BL01113C1q domain proteins.
1182BL01113A17.993.872e−10724-750BL01113C1q domain proteins.
1182BL01113A17.993.942e−091384-1410BL01113C1q domain proteins.
1182BL01113A17.993.942e−091414-1440BL01113C1q domain proteins.
1182BL01113A17.994.064e−101051-1077BL01113C1q domain proteins.
1182BL01113A17.994.068e−11931-957BL01113C1q domain proteins.
1182BL01113A17.994.255e−101375-1401BL01113C1q domain proteins.
1182BL01113A17.994.288e−09625-651BL01113C1q domain proteins.
1182BL01113A17.994.447e−101480-1506BL01113C1q domain proteins.
1182BL01113A17.994.447e−101570-1596BL01113C1q domain proteins.
1182BL01113A17.994.462e−121000-1026BL01113C1q domain proteins.
1182BL01113A17.994.462e−121249-1275BL01113C1q domain proteins.
1182BL01113A17.994.462e−12895-921BL01113C1q domain proteins.
1182BL01113A17.994.477e−111318-1344BL01113C1q domain proteins.
1182BL01113A17.994.635e−091027-1053BL01113C1q domain proteins.
1182BL01113A17.994.635e−091255-1281BL01113C1q domain proteins.
1182BL01113A17.994.635e−09601-627BL01113C1q domain proteins.
1182BL01113A17.994.808e−091279-1305BL01113C1q domain proteins.
1182BL01113A17.994.830e−101057-1083BL01113C1q domain proteins.
1182BL01113A17.994.830e−101312-1338BL01113C1q domain proteins.
1182BL01113A17.994.830e−10595-621BL01113C1q domain proteins.
1182BL01113A17.994.830e−10742-768BL01113C1q domain proteins.
1182BL01113A17.994.886e−111267-1293BL01113C1q domain proteins.
1182BL01113A17.994.892e−13796-822BL01113C1q domain proteins.
1182BL01113A17.994.923e−12814-840BL01113C1q domain proteins.
1182BL01113A17.994.981e−091213-1239BL01113C1q domain proteins.
1182BL01113A17.995.021e−10907-933BL01113C1q domain proteins.
1182BL01113A17.995.091e−111489-1515BL01113C1q domain proteins.
1182BL01113A17.995.154e−091321-1347BL01113C1q domain proteins.
1182BL01113A17.995.154e−091429-1455BL01113C1q domain proteins.
1182BL01113A17.995.295e−111045-1071BL01113C1q domain proteins.
1182BL01113A17.995.295e−111369-1395BL01113C1q domain proteins.
1182BL01113A17.995.295e−111558-1584BL01113C1q domain proteins.
1182BL01113A17.995.378e−131303-1329BL01113C1q domain proteins.
1182BL01113A17.995.378e−131357-1383BL01113C1q domain proteins.
1182BL01113A17.995.385e−121354-1380BL01113C1q domain proteins.
1182BL01113A17.995.385e−12529-555BL01113C1q domain proteins.
1182BL01113A17.995.404e−101063-1089BL01113C1q domain proteins.
1182BL01113A17.995.500e−091135-1161BL01113C1q domain proteins.
1182BL01113A17.995.500e−09898-924BL01113C1q domain proteins.
1182BL01113A17.995.615e−121477-1503BL01113C1q domain proteins.
1182BL01113A17.995.622e−13766-792BL01113C1q domain proteins.
1182BL01113A17.995.636e−141564-1590BL01113C1q domain proteins.
1182BL01113A17.995.705e−11781-807BL01113C1q domain proteins.
1182BL01113A17.995.787e−10604-630BL01113C1q domain proteins.
1182BL01113A17.995.846e−091285-1311BL01113C1q domain proteins.
1182BL01113A17.996.019e−09823-849BL01113C1q domain proteins.
1182BL01113A17.996.114e−111348-1374BL01113C1q domain proteins.
1182BL01113A17.996.182e−141495-1521BL01113C1q domain proteins.
1182BL01113A17.996.192e−091402-1428BL01113C1q domain proteins.
1182BL01113A17.996.365e−09904-930BL01113C1q domain proteins.
1182BL01113A17.996.455e−14 994-1020BL01113C1q domain proteins.
1182BL01113A17.996.538e−091186-1212BL01113C1q domain proteins.
1182BL01113A17.996.538e−09772-798BL01113C1q domain proteins.
1182BL01113A17.996.553e−101453-1479BL01113C1q domain proteins.
1182BL01113A17.996.553e−10709-735BL01113C1q domain proteins.
1182BL01113A17.996.595e−13721-747BL01113C1q domain proteins.
1182BL01113A17.996.712e−091501-1527BL01113C1q domain proteins.
1182BL01113A17.996.727e−11508-534BL01113C1q domain proteins.
1182BL01113A17.996.769e−12790-816BL01113C1q domain proteins.
1182BL01113A17.997.000e−121129-1155BL01113C1q domain proteins.
1182BL01113A17.997.058e−091519-1545BL01113C1q domain proteins.
1182BL01113A17.997.058e−09901-927BL01113C1q domain proteins.
1182BL01113A17.997.058e−09910-936BL01113C1q domain proteins.
1182BL01113A17.997.081e−13682-708BL01113C1q domain proteins.
1182BL01113A17.997.128e−101327-1353BL01113C1q domain proteins.
1182BL01113A17.997.136e−111423-1449BL01113C1q domain proteins.
1182BL01113A17.997.231e−09619-645BL01113C1q domain proteins.
1182BL01113A17.997.231e−09703-729BL01113C1q domain proteins.
1182BL01113A17.997.273e−141297-1323BL01113C1q domain proteins.
1182BL01113A17.997.341e−111258-1284BL01113C1q domain proteins.
1182BL01113A17.997.341e−11610-636BL01113C1q domain proteins.
1182BL01113A17.997.387e−151363-1389BL01113C1q domain proteins.
1182BL01113A17.997.511e−101054-1080BL01113C1q domain proteins.
1182BL01113A17.997.511e−101075-1101BL01113C1q domain proteins.
1182BL01113A17.997.545e−111420-1446BL01113C1q domain proteins.
1182BL01113A17.997.545e−111459-1485BL01113C1q domain proteins.
1182BL01113A17.997.545e−11784-810BL01113C1q domain proteins.
1182BL01113A17.997.545e−141114-1140BL01113C1q domain proteins.
1182BL01113A17.997.568e−131381-1407BL01113C1q domain proteins.
1182BL01113A17.997.577e−091210-1236BL01113C1q domain proteins.
1182BL01113A17.997.577e−091336-1362BL01113C1q domain proteins.
1182BL01113A17.997.577e−09631-657BL01113C1q domain proteins.
1182BL01113A17.997.750e−091183-1209BL01113C1q domain proteins.
1182BL01113A17.997.750e−091252-1278BL01113C1q domain proteins.
1182BL01113A17.997.923e−091102-1128BL01113C1q domain proteins.
1182BL01113A17.997.923e−091513-1539BL01113C1q domain proteins.
1182BL01113A17.997.923e−12880-906BL01113C1q domain proteins.
1182BL01113A17.998.085e−101465-1491BL01113C1q domain proteins.
1182BL01113A17.998.096e−091306-1332BL01113C1q domain proteins.
1182BL01113A17.998.138e−161486-1512BL01113C1q domain proteins.
1182BL01113A17.998.154e−121147-1173BL01113C1q domain proteins.
1182BL01113A17.998.269e−09958-984BL01113C1q domain proteins.
1182BL01113A17.998.277e−101417-1443BL01113C1q domain proteins.
1182BL01113A17.998.364e−111567-1593BL01113C1q domain proteins.
1182BL01113A17.998.468e−10532-558BL01113C1q domain proteins.
1182BL01113A17.998.615e−121132-1158BL01113C1q domain proteins.
1182BL01113A17.998.636e−141288-1314BL01113C1q domain proteins.
1182BL01113A17.998.660e−10889-915BL01113C1q domain proteins.
1182BL01113A17.998.788e−09691-717BL01113C1q domain proteins.
1182BL01113A17.998.788e−09760-786BL01113C1q domain proteins.
1182BL01113A17.998.846e−121099-1125BL01113C1q domain proteins.
1182BL01113A17.998.977e−111072-1098BL01113C1q domain proteins.
1182BL01113A17.999.043e−101573-1599BL01113C1q domain proteins.
1182BL01113A17.999.129e−151378-1404BL01113C1q domain proteins.
1182BL01113A17.999.135e−091462-1488BL01113C1q domain proteins.
1182BL01113A17.999.135e−09859-885BL01113C1q domain proteins.
1182BL01113A17.999.234e−101216-1242BL01113C1q domain proteins.
1182BL01113A17.999.270e−13775-801BL01113C1q domain proteins.
1182BL01113A17.999.270e−13 991-1017BL01113C1q domain proteins.
1182BL01113A17.999.426e−101066-1092BL01113C1q domain proteins.
1182BL01113A17.999.426e−10799-825BL01113C1q domain proteins.
1182BL01113A17.999.769e−121003-1029BL01113C1q domain proteins.
1182BL01113A17.999.769e−12505-531BL01113C1q domain proteins.
1182BL01113A17.999.827e−091180-1206BL01113C1q domain proteins.
1182BL01113A17.999.827e−091588-1614BL01113C1q domain proteins.
1182BL01113A17.999.827e−09955-981BL01113C1q domain proteins.
1182DM01418A20.831.000e−401668-1715DM01418352 FIBRILLAR COLLAGEN
CARBOXYL-TERMINAL.
1182DM01418B22.515.821e−391763-1804DM01418352 FIBRILLAR COLLAGEN
CARBOXYL-TERMINAL.
1182DM01418C20.481.000e−341831-1872DM01418352 FIBRILLAR COLLAGEN
CARBOXYL-TERMINAL.
1185BL00514C17.419.082e−28264-300BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1185BL00514D15.353.118e−11305-317BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1185BL00514G15.981.000e−14391-420BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1185BL00514H14.957.545e−13426-450BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1187BL50002A14.194.750e−12339-357BL50002Src homology 3 (SH3)
domain proteins
profile.
1187PR00452B11.655.500e−09349-364PR00452SH3 DOMAIN SIGNATURE
1188BL00663A11.518.364e−2244-64BL00663Vinculin family talin-
binding region
proteins.
1188BL00663B27.861000e−40 69-122BL00663Vinculin family talin-
binding region
proteins.
1188BL00663C22.591.000e−40131-185BL00663Vinculin family talin-
binding region
proteins.
1188BL00663D24.771.000e−40206-252BL00663Vinculin family talin-
binding region
proteins.
1188BL00663E21.192.200e−33254-291BL00663Vinculin family talin-
binding region
proteins.
1188BL00663F20.787.000e−40321-361BL00663Vinculin family talin-
binding region
proteins.
1188BL00663G24.171.000e−40393-442BL00663Vinculin family talin-
binding region
1188BL00663H27.091.000e−40465-517BL00663Vinculin family talin-
binding region
proteins.
1188BL00663I27.271.000e−40543-596BL00663Vinculin family talin-
binding region
proteins.
1188BL00663J18.161.000e−40725-761BL00663Vinculin family talin-
binding region
proteins.
1188BL00663K21.521.000e−40770-824BL00663Vinculin family talin-
binding region
proteins.
1188BL00663L20.679.053e−38837-872BL00663Vinculin family talin-
binding region
proteins.
1188PR00805A11.151.692e−3136-60PR00805ALPHA-CATENIN SIGNATURE
1188PR00805B14.821.409e−25134-152PR00805ALPHA-CATENIN SIGNATURE
1188PR00805C8.431.300e−23153-171PR00805ALPHA-CATENIN SIGNATURE
1188PR00805D7.821.257e−31329-353PR00805ALPHA-CATENIN SIGNATURE
1188PR00805E10.381.375e−27397-417PR00805ALPHA-CATENIN SIGNATURE
1188PR00805F11.721.375e−31518-542PR00805ALPHA-CATENIN SIGNATURE
1188PR00805G11.781.000e−31633-657PR00805ALPHA-CATENIN SIGNATURE
1188PR00805H14.971.161e−31735-757PR00805ALPHA-CATENIN SIGNATURE
1188PR00805I12.051.188e−32799-823PR00805ALPHA-CATENIN SIGNATURE
1188PR00805J7.442.800e−25879-897PR00805ALPHA-CATENIN SIGNATURE
1188PR00806C11.072.258e−09734-751PR00806VINCULIN SIGNATURE
1188PR00929C5.269.069e−0971-81PR00929AT-HOOK-LIKE DOMAIN
SIGNATURE
1189BL00223A15.591.911e−11 78-111BL00223Annexins repeat
proteins domain
proteins.
1189BL00223C24.795.725e−40 65-119BL00223Annexins repeat
proteins domain
proteins.
1189PR00196C10.366.311e−13 82-103PR00196ANNEXIN FAMILY
SIGNATURE
1189PR00196D21.866.400e−09 6-32PR00196ANNEXIN FAMILY
SIGNATURE
1189PR00196E9.197.128e−18 86-106PR00196ANNEXIN FAMILY
SIGNATURE
1189PR00196F13.891.000e−14114-129PR00196ANNEXIN FAMILY
SIGNATURE
1189PR00196G11.721.439e−11130-143PR00196ANNEXIN FAMILY
SIGNATURE
1189PR00197D7.501.297e−1082-103PR00197ANNEXIN TYPE I
SIGNATURE
1189PR00197F9.033.314e−1786-106PR00197ANNEXIN TYPE I
SIGNATURE
1189PR00198D7.651.175e−0982-103PR00198ANNEXIN TYPE II
SIGNATURE
1189PR00198G8.093.132e−1486-106PR00198ANNEXIN TYPE II
SIGNATURE
1189PR00198H12.059.663e−09130-143PR00198ANNEXIN TYPE II
SIGNATURE
1189PR00199D5.658.699e−11 82-103PR00199ANNEXIN TYPE III
SIGNATURE
1189PR00199G9.092.588e−20 87-112PR00199ANNEXIN TYPE III
SIGNATURE
1189PR00199H12.623.000e−15130-143PR00199ANNEXIN TYPE III
SIGNATURE
1189PR00200E10.001.489e−11 82-103PR00200ANNEXIN TYPE IV
SIGNATURE
1189PR00200G9.431.000e−18 86-112PR00200ANNEXIN TYPE IV
SIGNATURE
1189PR00200H13.682.987e−11130-143PR00200ANNEXIN TYPE IV
SIGNATURE
1189PR00201D10.498.981e−09 82-103PR00201ANNEXIN TYPE V
SIGNATURE
1189PR00201G11.021.625e−21 86-112PR00201ANNEXIN TYPE V
SIGNATURE
1189PR00201H12.048.024e−11130-143PR00201ANNEXIN TYPE V
SIGNATURE
1189PR00202G8.019.538e−21 86-112PR00202ANNEXIN TYPE VI
SIGNATURE
1189PR00202H9.202.800e−10130-143PR00202ANNEXIN TYPE VI
SIGNATURE
1190BL00593A13.256.700e−3038-63BL00593Heme oxygenase
proteins.
1190BL00593B13.381.000e−40 72-115BL00593Heme oxygenase
proteins.
1190BL00593C10.021.000e−40144-188BL00593Heme oxygenase
proteins.
1190BL00593D19.911.000e−40192-244BL00593Heme oxygenase
proteins.
1190BL00593E13.324.000e−24292-314BL00593Heme oxygenase
proteins.
1190PR00088A13.371.237e−2938-63PR00088HAEM OXYGENASE
SIGNATURE
1190PR00088B14.555.615e−2973-98PR00088HAEM OXYGENASE
SIGNATURE
1190PR00088C13.007.395e−3099-124PR00088HAEM OXYGENASE
SIGNATURE
1190PR00088D16.751.000e−27152-173PR00088HAEM OXYGENASE
SIGNATURE
1190PR00088E11.904.900e−25174-195PR00088HAEM OXYGENASE
SIGNATURE
1190PR00088F12.623.025e−24196-217PR00088HAEM OXYGENASE
SIGNATURE
1190PR00088G10.677.429e−21228-246PR00088HAEM OXYGENASE
SIGNATURE
1193BL00388A23.141.257e−3315-60BL00388Proteasome A-type
subunits proteins.
1193BL00388B31.387.429e−28 74-115BL00388Proteasome A-type
subunits proteins.
1193BL00388C18.799.710e−17129-150BL00388Proteasome A-type
subunits proteins.
1193BL00388D20.713.382e−20157-187BL00388Proteasome A-type
subunits proteins.
1193PF0022714.685.950e−0922-33PF00227Proteasome A-type and
B-type.
1194BL00061B25.792.636e−17219-256BL00061Short-chain
dehydrogenases/reductases
family proteins.
1194PR00080C17.168.714e−13239-258PR00080ALCOHOL DEHYDROGENASE
SUPERFAMILY SIGNATURE
1194PR00081A10.535.979e−10 91-108PR00081GLUCOSE/RIBITOL
DEHYDROGENASE FAMILY
SIGNATURE
1194PR00081C15.139.654e−11213-229PR00081GLUCOSE/RIBITOL
DEHYDROGENASE FAMILY
SIGNATURE
1194PR00081D15.801.231e−10239-258PR00081GLUCOSE/RIBITOL
DEHYDROGENASE FAMILY
SIGNATURE
1195BL00326A14.019.686e−0934-67BL00326Tropomyosins proteins.
1197PF0065115.007.857e−10345-357PF00651BTB (also known as BR-
C/Ttk) domain proteins.
1199PR00001A12.789.379e−1538-51PR00001COAGULATION FACTOR GLA
DOMAIN SIGNATURE
1199PR00001B10.756.932e−1352-65PR00001COAGULATION FACTOR GLA
DOMAIN SIGNATURE
1199PR00001C16.602.459e−1166-80PR00001COAGULATION FACTOR GLA
DOMAIN SIGNATURE
1200PD002899.974.103e−09160-173PD00289PROTEIN SH3 DOMAIN
REPEAT PRESYNA.
1201BL00107A18.393.118e−20733-763BL00107Protein kinases ATP-
binding region
proteins.
1201BL00107B13.318.615e−12803-818BL00107Protein kinases ATP-
binding region
proteins.
1201BL00239B25.159.224e−21667-714BL00239Receptor tyrosine
kinase class II
proteins.
1201BL00239C18.757.474e−13720-742BL00239Receptor tyrosine
kinase class II
proteins.
1201BL00239D16.812.373e−11745-770BL00239Receptor tyrosine
kinase class II
proteins.
1201BL00239E17.144.682e−24775-824BL00239Receptor tyrosine
kinase class II
proteins.
1201BL00239F28.152.929e−20829-873BL00239Receptor tyrosine
kinase class II
proteins.
1201BL00240E11.567.808e−17719-756BL00240Receptor tyrosine
kinase class III
proteins.
1201BL00240F17.749.241e−19774-821BL00240Receptor tyrosine
kinase class III
proteins.
1201BL00240G28.452.611e−11821-873BL00240Receptor tyrosine
kinase class III
proteins.
1201BL00790A19.745.371e−1720-41BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790B21.591.000e−40 53-104BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790C16.651.000e−40161-214BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790D12.412.703e−22238-262BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790E29.586.400e−39271-318BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790F15.907.250e−22337-363BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790G22.062.846e−34373-416BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790H13.421.771e−23452-477BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790I20.018.941e−27499-529BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790J14.211.000e−40588-627BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790K9.301.000e−40640-693BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790L11.163.423e−24704-723BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790M8.744.977e−26724-745BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790N13.258.071e−31746-772BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790O7.681.000e−40782-814BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790P12.331.281e−30815-839BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790Q15.611.000e−40840-888BL00790Receptor tyrosine
kinase class V
proteins.
1201BL00790R16.204.000e−39931-974BL00790Receptor tyrosine
kinase class V
proteins.
1201BL50001B17.403.647e−13730-750BL50001Src homology 2 (SH2)
domain proteins
profile.
1201BL50001C10.171.000e−09784-794BL50001Src homology 2 (SH2)
domain proteins
profile.
1201PR00014D12.043.077e−12506-520PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1201PR00109A15.001.409e−12696-709PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1201PR00109B12.271.000e−19733-751PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1201PR00109C12.855.235e−12785-795PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1201PR00109D17.042.038e−20804-826PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1201PR00109E14.418.500e−18848-870PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1203DM0021519.439.390e−09157-189DM00215PROLINE-RICH PROTEIN 3.
1203PR00049D0.007.254e−09175-189PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1204BL00225A13.823.127e−091133-1153BL00225Crystallins beta and
gamma ‘Greek key’ motif
proteins.
1204BL00225A13.825.829e−121417-1437BL00225Crystallins beta and
gamma ‘Greek key’ motif
proteins.
1204BL00225B18.062.575e−191270-1304BL00225Crystallins beta and
gamma ‘Greek key’ motif
proteins.
1204BL00225B18.064.808e−14 970-1004BL00225Crystallins beta and
gamma ‘Greek key’ motif
proteins.
1204BL00225B18.065.500e−141451-1485BL00225Crystallins beta and
gamma ‘Greek key’ motif
proteins.
1204BL00225B18.067.517e−241179-1213BL00225Crystallins beta and
gamma ‘Greek key’ motif
proteins.
1204BL00225B18.068.200e−191072-1106BL00225Crystallins beta and
gamma ‘Greek key’ motif
proteins.
1204BL00225B18.068.297e−201361-1395BL00225Crystallins beta and
gamma ‘Greek key’ motif
proteins.
1205BL00266B24.488.457e−2119-56BL00266Somatotropin, prolactin
and related hormones
proteins.
1205PR00836A14.402.800e−1319-32PR00836SOMATOTROPIN HORMONE
FAMILY SIGNATURE
1205PR00836B16.595.814e−1041-59PR00836SOMATOTROPIN HORMONE
FAMILY SIGNATURE
1205PR00836C11.951.000e−12119-135PR00836SOMATOTROPIN HORMONE
FAMILY SIGNATURE
1206BL0004612.951.000e−40 59-113BL00046Histone H2A proteins.
1206PR00620A11.032.636e−2740-62PR00620HISTONE H2A SIGNATURE
1206PR00620B8.471.750e−2069-84PR00620HISTONE H2A SIGNATURE
1206PR00620C10.192.125e−1784-97PR00620HISTONE H2A SIGNATURE
1206PR00620D11.391.692e−19 98-112PR00620HISTONE H2A SIGNATURE
1206PR00620E8.912.500e−16112-124PR00620HISTONE H2A SIGNATURE
1206PR00620F7.297.750e−22126-144PR00620HISTONE H2A SIGNATURE
1208BL00309A19.167.545e−2075-99BL00309Vertebrate galactoside-
binding lectin
proteins.
1208BL00309B12.116.000e−16101-115BL00309Vertebrate galactoside-
binding lectin
proteins.
1208BL00309C18.655.000e−24123-147BL00309Vertebrate galactoside-
binding lectin
proteins.
1209PF00075B12.564.073e−10260-270PF00075RNase H.
1209PF00075C11.589.786e−11295-306PF00075RNase H.
1209PF00075D10.717.000e−11327-337PF00075RNase H.
1209PF00075F12.874.750e−11685-695PF00075RNase H.
1209PF00075J15.788.350e−11980-997PF00075RNase H.
1209PF0042931.083.492e−171105-1154PF00429ENV polyprotein (coat
polyprotein).
1210BL00272C8.278.326e−09 95-106BL00272Snake toxins proteins.
1210BL00983C12.694.981e−09 91-106BL00983Ly-6/u-PAR domain
proteins.
1211BL00139A10.297.261e−14320-329BL00139Eukaryotic thiol
(cysteine) proteases
cysteine proteins.
1211BL00139C9.231.000e−11461-470BL00139Eukaryotic thiol
(cysteine) proteases
cysteine proteins.
1211BL00139D9.245.125e−17477-493BL00139Eukaryotic thiol
(cysteine) proteases
cysteine proteins.
1211PR00705A10.556.294e−16320-335PR00705PAPAIN CYSTEINE
PROTEASE (C1) FAMILY
SIGNATURE
1211PR00705B10.221.844e−09462-472PR00705PAPAIN CYSTEINE
PROTEASE (C1) FAMILY
SIGNATURE
1214BL0028216.886.294e−1112-34BL00282Kazal serine protease
inhibitors family
proteins.
1216BL01177C17.392.875e−20109-127BL01177Anaphylatoxin domain
proteins.
1216BL01187A9.981.000e−12100-111BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1216BL01187A9.986.625e−0958-69BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1216BL01187B12.043.250e−1476-91BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1216BL01187B12.046.478e−13115-130BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1216PR00010A11.799.308e−09102-113PR00010TYPE II EGF-LIKE
SIGNATURE
1216PR00010C11.165.714e−0981-91PR00010TYPE II EGF-LIKE
SIGNATURE
1218BL00226D19.101.000e−4031-77BL00226Intermediate filaments
proteins.
1219BL00107A18.396.192e−12211-241BL00107Protein kinases ATP-
binding region
proteins.
1219BL00239B25.158.909e−17146-193BL00239Receptor tyrosine
kinase class II
proteins.
1219BL00240D23.073.483e−09135-189BL00240Receptor tyrosine
kinase class III
proteins.
1219BL00240E11.566.185e−12197-234BL00240Receptor tyrosine
kinase class III
proteins.
1219BL00479C12.012.000e−09263-275BL00479Phorbol esters/
diacylglycerol binding
domain proteins.
1219BL00790M8.743.571e−09202-223BL00790Receptor tyrosine
kinase class V
proteins.
1219PR00109A15.001.486e−09175-188PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1219PR00109B12.275.596e−13211-229PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1221BL00421E20.975.125e−1641-70BL00421Transmembrane 4 family
proteins.
1221PR00259D13.502.241e−2144-70PR00259TRANSMEMBRANE FOUR
FAMILY SIGNATURE
1222BL00540B18.821.000e−40 50-104BL00540Ferritin iron-binding
regions proteins.
1222BL00540C13.007.750e−14115-126BL00540Ferritin iron-binding
regions proteins.
1223BL00824B9.217.750e−22 89-108BL00824Elongation factor 1
beta/beta'/delta chain
proteins.
1224BL00266A15.699.000e−1930-56BL00266Somatotropin, prolactin
and related hormones
proteins.
1224BL00266B24.487.261e−16 74-111BL00266Somatotropin, prolactin
and related hormones
proteins.
1224PR00836A14.409.379e−1174-87PR00836SOMATOTROPIN HORMONE
FAMILY SIGNATURE
1225PF00084C11.253.571e−1034-43PF00084Sushi domain proteins
(SCR repeat proteins.
1227BL00475C13.063.700e−1757-73BL00475Ribosomal protein L15
proteins.
1228PR00702G9.632.625e−0922-45PR00702ACRIFLAVIN RESISTANCE
PROTEIN FAMILY
SIGNATURE
1231PD02269B18.482.667e−27 74-100PD02269CYTIDINE DEAMINASE
HYDROLASE ZINC AMINOHY.
1231PD02269C16.367.882e−17119-131PD02269CYTIDINE DEAMINASE
HYDROLASE ZINC AMINOHY.
1232BL00061A9.414.600e−13105-115BL00061Short-chain
dehydrogenases/reductases
family proteins.
1232PR00080A9.323.143e−12105-116PR00080ALCOHOL DEHYDROGENASE
SUPERFAMILY SIGNATURE
1232PR00081B10.388.800e−14105-116PR00081GLUCOSE/RIBITOL
DEHYDROGENASE FAMILY
SIGNATURE
1233BL00064A21.161.000e−3348-85BL00064L-lactate dehydrogenase
proteins.
1233BL00957A8.319.609e−0948-63BL00957NAD-dependent glycerol-
3-phosphate
dehydrogenase proteins.
1233PR00086A16.124.000e−2648-72PR00086L-LACTATE DEHYDROGENASE
SIGNATURE
1233PR00086B13.674.462e−2473-97PR00086L-LACTATE DEHYDROGENASE
SIGNATURE
1234BL00353B11.471.000e−40 65-114BL00353HMG1/2 proteins.
1234BL00353C14.835.680e−24115-161BL00353HMG1/2 proteins.
1234BL00353C14.837.254e−0931-77BL00353HMG1/2 proteins.
1234PR00886A10.082.929e−3027-49PR00886HIGH MOBILITY GROUP
(HMG1/HMG2) PROTEIN
SIGNATURE
1234PR00886B9.886.625e−2750-70PR00886HIGH MOBILITY GROUP
(HMG1/HMG2) PROTEIN
SIGNATURE
1234PR00886C11.841.500e−22 97-115PR00886HIGH MOBILITY GROUP
(HMG1/HMG2) PROTEIN
SIGNATURE
1234PR00886D15.724.830e−14115-134PR00886HIGH MOBILITY GROUP
(HMG1/HMG2) PROTEIN
SIGNATURE
1234PR00886E8.859.316e−0950-70PR00886HIGH MOBILITY GROUP
(HMG1/HMG2) PROTEIN
SIGNATURE
1235BL00740A13.877.200e−1064-76BL00740MAM domain proteins.
1235PR00020A18.176.684e−1062-80PR00020MAM DOMAIN SIGNATURE
1236BL01187A9.983.250e−0968-79BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1236BL01187A9.983.571e−1027-38BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1236BL01187B12.041.391e−1346-61BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1236BL01187B12.042.000e−12 5-20BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1236BL01187B12.044.375e−09 86-101BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1236PR00010C11.167.000e−0951-61PR00010TYPE II EGF-LIKE
SIGNATURE
1236PR00907G11.636.514e−0946-72PR00907THROMBOMODULIN
SIGNATURE
1236PR00907G11.638.622e−09 5-31PR00907THROMBOMODULIN
SIGNATURE
1237BL0028717.351.947e−2025-48BL00287Cysteine proteases
inhibitors proteins.
1245DM00303A13.203.382e−11 52-101DM003036 LEA 11-MER REPEAT
REPEAT.
1246BL00064C17.281.000e−4018-62BL00064L-lactate dehydrogenase
proteins.
1246BL00064D14.198.875e−3263-92BL00064L-lactate dehydrogenase
proteins.
1246BL00068C29.083.089e−1714-60BL00068Malate dehydrogenase
proteins.
1246PR00086C16.226.400e−2515-35PR00086L-LACTATE DEHYDROGENASE
SIGNATURE
1246PR00086D15.534.600e−2439-57PR00086L-LACTATE DEHYDROGENASE
SIGNATURE
1246PR00086E11.218.364e−1869-82PR00086L-LACTATE DEHYDROGENASE
SIGNATURE
1251BL001428.384.429e−09430-440BL00142Neutral zinc
metallopeptidases,
zinc-binding region
proteins.
1251PD01719A12.893.429e−14594-621PD01719PRECURSOR GLYCOPROTEIN
SIGNAL RE.
1251PD01719A12.899.408e−10943-970PD01719PRECURSOR GLYCOPROTEIN
SIGNAL RE.
1254BL00319C17.121.592e−0943-76BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1254BL00319C17.122.625e−10106-139BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1254BL00319C17.123.013e−09100-133BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1254BL00319C17.123.857e−12101-134BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1254BL00319C17.124.671e−09107-140BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1254BL00319C17.124.875e−10 97-130BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1254BL00319C17.125.836e−1144-77BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1254BL00319C17.127.625e−10104-137BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1254BL00319C17.128.105e−09 98-131BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1254BL00319C17.128.800e−13102-135BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1254BL00319C17.128.857e−12105-138BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1254BL00319C17.129.289e−0939-72BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1254BL00319C17.129.289e−09 96-129BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1254BL00412D16.543.935e−10 66-116BL00412Neuromodulin (GAP-43)
proteins.
1254BL00412D16.546.283e−10 93-143BL00412Neuromodulin (GAP-43)
proteins.
1254BL00412D16.546.420e−11 68-118BL00412Neuromodulin (GAP-43)
proteins.
1254BL00824B9.212.216e−09107-126BL00824Elongation factor 1
beta/beta′/delta chain
proteins.
1254BL00824B9.212.338e−09106-125BL00824Elongation factor 1
beta/beta′/delta chain
proteins.
1254BL00824B9.214.770e−09105-124BL00824Elongation factor 1
beta/beta′/delta chain
proteins.
1254BL00824B9.215.257e−0945-64BL00824Elongation factor 1
beta/beta′/delta chain
proteins.
1254BL00824B9.218.435e−10102-121BL00824Elongation factor 1
beta/beta′/delta chain
proteins.
1254BL00884B12.479.664e−09 76-119BL00884Osteopontin proteins.
1254BL01115D14.496.924e−0914-45BL01115GTP-binding nuclear
protein ran proteins.
1254PD00301A10.241.900e−09116-126PD00301PROTEIN REPEAT MUSCLE
CALCIUM-BI.
1254PD00919F11.635.107e−0933-61PD00919CALCIUM-BINDING
PRECURSOR SIGNAL R.
1254PF00922A19.174.951e−10 92-125PF00922Vesiculovirus
phosphoprotein.
1254PF00922A19.175.966e−09 94-127PF00922Vesiculovirus
phosphoprotein.
1254PF00922A19.176.690e−09 91-124PF00922Vesiculovirus
phosphoprotein.
1254PF00922A19.179.561e−10 93-126PF00922Vesiculovirus
phosphoprotein.
1255PR00121B7.839.250e−09 87-107PR00121SODIUM/POTASSIUM-
TRANSPORTING ATPASE
SIGNATURE
1256BL00406B5.471.000e−40 72-126BL00406Actins proteins.
1256PR00190A7.241.375e−1315-24PR00190ACTIN SIGNATURE
1256PR00190B9.981.000e−1538-49PR00190ACTIN SIGNATURE
1256PR00190C11.491.474e−3050-72PR00190ACTIN SIGNATURE
1256PR00190D19.231.450e−2673-91PR00190ACTIN SIGNATURE
1256PR00190E7.161.450e−19104-117PR00190ACTIN SIGNATURE
1258BL00389A11.027.188e−1037-49BL00389ATP synthase delta
(OSCP) subunit
proteins.
1258BL00389B17.026.211e−13107-128BL00389ATP synthase delta
(OSCP) subunit
proteins.
1258BL00389C20.136.760e−25168-205BL00389ATP synthase delta
(OSCP) subunit
proteins.
1258PR00125A16.038.364e−1537-56PR00125ATP SYNTHASE DELTA
SUBUNIT SIGNATURE
1258PR00125B12.788.125e−10106-117PR00125ATP SYNTHASE DELTA
SUBUNIT SIGNATURE
1258PR00125D11.005.345e−11169-184PR00125ATP SYNTHASE DELTA
SUBUNIT SIGNATURE
1258PR00125E13.569.250e−16184-202PR00125ATP SYNTHASE DELTA
SUBUNIT SIGNATURE
1260BL006789.671.947e−09194-204BL00678Trp-Asp (WD) repeat
proteins proteins.
1260BL006789.679.053e−09290-300BL00678Trp-Asp (WD) repeat
proteins proteins.
1260PR00320A16.742.862e−11288-302PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1260PR00320A16.742.976e−09332-346PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1260PR00320A16.745.714e−13192-206PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1260PR00320B12.191.783e−13288-302PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1260PR00320B12.195.114e−10192-206PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1260PR00320C13.011.783e−11332-346PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1260PR00320C13.013.400e−09192-206PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1260PR00320C13.019.640e−10288-302PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1261BL006789.677.158e−0969-79BL00678Trp-Asp (WD) repeat
proteins proteins.
1261PR00320A16.746.707e−09203-217PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1261PR00320A16.749.122e−0967-81PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1261PR00320B12.191.514e−1067-81PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1261PR00320C13.012.500e−0967-81PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1261PR00320C13.014.960e−10203-217PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1262BL00019A12.563.475e−1373-83BL00019Actinin-type actin-
binding domain
proteins.
1262BL00019B13.344.288e−102002-2024BL00019Actinin-type actin-
binding domain
proteins.
1262BL00019B13.349.135e−10 98-120BL00019Actinin-type actin-
binding domain
proteins.
1262BL00019C14.664.800e−30146-181BL00019Actinin-type actin-
binding domain
proteins.
1262BL00019D15.332.623e−132465-2494BL00019Actinin-type actin-
binding domain
proteins.
1262BL00019D15.338.105e−09210-239BL00019Actinin-type actin-
binding domain
proteins.
1262BL00019F19.686.609e−09182-203BL00019Actinin-type actin-
binding domain
proteins.
1264BL00514C17.414.000e−2959-95BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1264BL00514D15.357.511e−12100-112BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1264BL00514E14.283.951e−10119-135BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1264BL00514G15.982.268e−16184-213BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1264BL00514H14.957.245e−15217-241BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1265BL00038B16.974.273e−11112-132BL00038Myc-type, ‘helix-loop-
helix’ dimerization
domain proteins.
1266BL00421A11.793.864e−20 8-26BL00421Transmembrane 4 family
proteins.
1266BL00421B17.625.737e−39 62-100BL00421Transmembrane 4 family
proteins.
1266BL00421C12.893.667e−11146-157BL00421Transmembrane 4 family
proteins.
1266BL00421E20.974.115e−26192-221BL00421Transmembrane 4 family
proteins.
1266BL00456C24.557.223e−09 52-106BL00456Sodium: solute symporter
family proteins.
1266PD02680A23.519.341e−10 60-110PD02680TRANSPORT GLUCONATE
TRANSMEMBRANE PROTEIN
PERMEA.
1266PR00259A9.272.241e−2212-35PR00259TRANSMEMBRANE FOUR
FAMILY SIGNATURE
1266PR00259B14.818.071e−2856-82PR00259TRANSMEMBRANE FOUR
FAMILY SIGNATURE
1266PR00259C16.402.688e−30 83-111PR00259TRANSMEMBRANE FOUR
FAMILY SIGNATURE
1266PR00259D13.504.316e−26195-221PR00259TRANSMEMBRANE FOUR
FAMILY SIGNATURE
1268BL00223A15.594.783e−14252-285BL00223Annexins repeat
proteins domain
proteins.
1268BL00223A15.595.500e−21 93-126BL00223Annexins repeat
proteins domain
proteins.
1268BL00223A15.595.500e−3221-54BL00223Annexins repeat
proteins domain
proteins.
1268BL00223B28.471.000e−40162-211BL00223Annexins repeat
proteins domain
proteins.
1268BL00223C24.791.000e−40239-293BL00223Annexins repeat
proteins domain
proteins.
1268BL00223C24.791.424e−14 80-134BL00223Annexins repeat
proteins domain
proteins.
1268BL00223C24.792.515e−10 8-62BL00223Annexins repeat
proteins domain
proteins.
1268PR00196A11.166.704e−10102-124PR00196ANNEXIN FAMILY
SIGNATURE
1268PR00196A11.169.100e−2130-52PR00196ANNEXIN FAMILY
SIGNATURE
1268PR00196B10.683.700e−1770-86PR00196ANNEXIN FAMILY
SIGNATURE
1268PR00196C10.362.174e−23 97-118PR00196ANNEXIN FAMILY
SIGNATURE
1268PR00196C10.365.167e−1525-46PR00196ANNEXIN FAMILY
SIGNATURE
1268PR00196C10.367.344e−13256-277PR00196ANNEXIN FAMILY
SIGNATURE
1268PR00196D21.863.032e−24180-206PR00196ANNEXIN FAMILY
SIGNATURE
1268PR00196E9.191.118e−10101-121PR00196ANNEXIN FAMILY
SIGNATURE
1268PR00196E9.198.333e−23260-280PR00196ANNEXIN FAMILY
SIGNATURE
1268PR00196F13.892.714e−15288-303PR00196ANNEXIN FAMILY
SIGNATURE
1268PR00196F13.894.188e−09129-144PR00196ANNEXIN FAMILY
SIGNATURE
1268PR00196G11.723.000e−14304-317PR00196ANNEXIN FAMILY
SIGNATURE
1268PR00196G11.729.217e−10229-242PR00196ANNEXIN FAMILY
SIGNATURE
1268PR00197B7.562.206e−0930-52PR00197ANNEXIN TYPE I
1268PR00197D7.501.250e−1525-46PR00197ANNEXIN TYPE I
SIGNATURE
1268PR00197D7.501.542e−12256-277PR00197ANNEXIN TYPE I
SIGNATURE
1268PR00197D7.501.844e−18 97-118PR00197ANNEXIN TYPE I
SIGNATURE
1268PR00197E11.898.463e−14180-206PR00197ANNEXIN TYPE I
SIGNATURE
1268PR00197F9.035.250e−16260-280PR00197ANNEXIN TYPE I
SIGNATURE
1268PR00197F9.037.894e−10101-121PR00197ANNEXIN TYPE I
SIGNATURE
1268PR00198B8.719.357e−1030-52PR00198ANNEXIN TYPE II
SIGNATURE
1268PR00198C14.326.718e−1070-86PR00198ANNEXIN TYPE II
SIGNATURE
1268PR00198D7.652.271e−13256-277PR00198ANNEXIN TYPE II
SIGNATURE
1268PR00198D7.658.333e−15 97-118PR00198ANNEXIN TYPE II
SIGNATURE
1268PR00198D7.659.894e−1325-46PR00198ANNEXIN TYPE II
SIGNATURE
1268PR00198E14.676.381e−11180-206PR00198ANNEXIN TYPE II
SIGNATURE
1268PR00198G8.094.656e−09101-121PR00198ANNEXIN TYPE II
SIGNATURE
1268PR00198G8.097.943e−16260-280PR00198ANNEXIN TYPE II
SIGNATURE
1268PR00198H12.051.462e−10304-317PR00198ANNEXIN TYPE II
SIGNATURE
1268PR00199B6.861.574e−1330-52PR00199ANNEXIN TYPE III
SIGNATURE
1268PR00199B6.868.313e−09102-124PR00199ANNEXIN TYPE III
SIGNATURE
1268PR00199C13.841.857e−0970-86PR00199ANNEXIN TYPE III
SIGNATURE
1268PR00199D5.653.443e−15 97-118PR00199ANNEXIN TYPE III
SIGNATURE
1268PR00199D5.655.375e−1425-46PR00199ANNEXIN TYPE III
SIGNATURE
1268PR00199D5.657.987e−13256-277PR00199ANNEXIN TYPE III
SIGNATURE
1268PR00199F16.195.636e−16180-206PR00199ANNEXIN TYPE III
SIGNATURE
1268PR00199G9.096.365e−09102-127PR00199ANNEXIN TYPE III
SIGNATURE
1268PR00199G9.098.364e−21261-286PR00199ANNEXIN TYPE III
SIGNATURE
1268PR00199H12.625.339e−12304-317PR00199ANNEXIN TYPE III
SIGNATURE
1268PR00200A4.932.125e−14 5-15PR00200ANNEXIN TYPE IV
SIGNATURE
1268PR00200B7.391.643e−2930-52PR00200ANNEXIN TYPE IV
SIGNATURE
1268PR00200C8.761.500e−1254-62PR00200ANNEXIN TYPE IV
SIGNATURE
1268PR00200D10.012.286e−2270-86PR00200ANNEXIN TYPE IV
SIGNATURE
1268PR00200E10.001.110e−27 97-118PR00200ANNEXIN TYPE IV
SIGNATURE
1268PR00200E10.002.111e−1425-46PR00200ANNEXIN TYPE IV
SIGNATURE
1268PR00200E10.002.859e−11256-277PR00200ANNEXIN TYPE IV
SIGNATURE
1268PR00200F13.721.118e−35180-206PR00200ANNEXIN TYPE IV
SIGNATURE
1268PR00200G9.431.000e−34260-286PR00200ANNEXIN TYPE IV
SIGNATURE
1268PR00200G9.431.983e−09101-127PR00200ANNEXIN TYPE IV
SIGNATURE
1268PR00200G9.435.294e−1129-55PR00200ANNEXIN TYPE IV
SIGNATURE
1268PR00200H13.681.766e−18304-317PR00200ANNEXIN TYPE IV
SIGNATURE
1268PR00201A6.054.770e−1630-52PR00201ANNEXIN TYPE V
SIGNATURE
1268PR00201C11.139.316e−1270-86PR00201ANNEXIN TYPE V
SIGNATURE
1268PR00201D10.491.456e−15 97-118PR00201ANNEXIN TYPE V
SIGNATURE
1268PR00201D10.496.179e−0925-46PR00201ANNEXIN TYPE V
SIGNATURE
1268PR00201E12.374.103e−15180-206PR00201ANNEXIN TYPE V
SIGNATURE
1268PR00201G11.028.402e−1029-55PR00201ANNEXIN TYPE V
SIGNATURE
1268PR00201G11.029.419e−26260-286PR00201ANNEXIN TYPE V
SIGNATURE
1268PR00201G11.029.912e−11101-127PR00201ANNEXIN TYPE V
SIGNATURE
1268PR00201H12.044.375e−14304-317PR00201ANNEXIN TYPE V
SIGNATURE
1268PR00202B11.442.763e−1129-52PR00202ANNEXIN TYPE VI
SIGNATURE
1268PR00202C13.343.800e−1170-86PR00202ANNEXIN TYPE VI
SIGNATURE
1268PR00202D5.581.908e−0925-46PR00202ANNEXIN TYPE VI
SIGNATURE
1268PR00202D5.583.224e−15 97-118PR00202ANNEXIN TYPE VI
SIGNATURE
1268PR00202E13.004.643e−16180-206PR00202ANNEXIN TYPE VI
SIGNATURE
1268PR00202G8.014.833e−28260-286PR00202ANNEXIN TYPE VI
SIGNATURE
1268PR00202G8.015.881e−09101-127PR00202ANNEXIN TYPE VI
SIGNATURE
1268PR00202G8.019.237e−0929-55PR00202ANNEXIN TYPE VI
SIGNATURE
1268PR00202H9.204.740e−11304-317PR00202ANNEXIN TYPE VI
SIGNATURE
1268PR00301D15.517.395e−0938-58PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1269BL01179A12.631.429e−11209-220BL01179Phosphotyrosine
interaction domain
proteins (PID) profile.
1269BL01179B15.189.679e−11400-414BL01179Phosphotyrosine
interaction domain
proteins (PID) profile.
1270BL01033A16.947.923e−1825-46BL01033Globins profile.
1270BL01033B13.811.000e−15 93-104BL01033Globins profile.
1270PR00612D9.763.415e−1080-93PR00612ALPHA HAEMOGLOBIN
SIGNATURE
1270PR00814A12.945.500e−2230-46PR00814BETA HAEMOGLOBIN
SIGNATURE
1270PR00814B9.183.250e−1748-63PR00814BETA HAEMOGLOBIN
SIGNATURE
1270PR00814C9.204.273e−1672-89PR00814BETA HAEMOGLOBIN
SIGNATURE
1270PR00814D15.252.286e−0994-99PR00814BETA HAEMOGLOBIN
SIGNATURE
1270PR00814E10.178.071e−19128-144PR00814BETA HAEMOGLOBIN
SIGNATURE
1273BL00407A18.578.500e−3511-47BL00407Connexins proteins.
1273BL00407B14.231.000e−3548-78BL00407Connexins proteins.
1273BL00407C14.616.850e−31 79-106BL00407Connexins proteins.
1273BL00407D17.615.091e−28157-186BL00407Connexins proteins.
1273BL00407E22.171.000e−40195-239BL00407Connexins proteins.
1273PR00206A11.359.053e−2729-53PR00206CONNEXIN SIGNATURE
1273PR00206B13.757.882e−3060-82PR00206CONNEXIN SIGNATURE
1273PR00206C15.163.842e−23 85-105PR00206CONNEXIN SIGNATURE
1273PR00206D16.574.429e−26159-185PR00206CONNEXIN SIGNATURE
1273PR00206E15.091.857e−25195-215PR00206CONNEXIN SIGNATURE
1273PR00206F16.776.571e−23216-239PR00206CONNEXIN SIGNATURE
1274BL00021B13.333.786e−1834-51BL00021Kringle domain
proteins.
1274BL00021D24.564.759e−11190-231BL00021Kringle domain
proteins.
1274BL00134A11.969.609e−1834-50BL00134Serine proteases,
trypsin family,
histidine proteins.
1274BL00134B15.995.714e−19185-208BL00134Serine proteases,
trypsin family,
histidine proteins.
1274BL00134C13.454.750e−12218-231BL00134Serine proteases,
trypsin family,
histidine proteins.
1274BL00495K12.583.796e−0936-68BL00495Apple domain proteins.
1274BL01253D4.849.855e−1234-47BL01253Type I fibronectin
domain proteins.
1274BL01253G11.347.972e−14184-197BL01253Type I fibronectin
domain proteins.
1274BL01253H13.157.680e−12200-234BL01253Type I fibronectin
domain proteins.
1274PR00722A12.276.087e−1635-50PR00722CHYMOTRYPSIN SERINE
PROTEASE FAMILY (S1)
SIGNATURE
1274PR00722C10.875.500e−15184-196PR00722CHYMOTRYPSIN SERINE
PROTEASE FAMILY (S1)
SIGNATURE
1276PD01876C21.738.529e−11461-513PD01876ANTIGEN MELANOMA-
ASSOCIATED MULTIGENE
FAMILY TUM.
1276PR00411A15.954.724e−09749-771PR00411PYRIDINE NUCLEOTIDE
DISULPHIDE REDUCTASE
CLASS-I SIGNATURE
1279BL0131014.741.321e−3628-63BL01310ATP1G1/PLM/MAT8
family proteins.
1281BL00296B15.986.625e−09 83-136BL00296Chaperonins cpn60
proteins.
1281BL00750A20.071.310e−3032-74BL00750Chaperonins TCP-1
proteins.
1281BL00750B16.177.517e−37 76-125BL00750Chaperonins TCP-1
proteins.
1281BL00750C25.652.909e−15157-188BL00750Chaperonins TCP-1
proteins.
1281BL00750D16.169.719e−11206-224BL00750Chaperonins TCP-1
proteins.
1281BL00750E24.592.406e−21296-332BL00750Chaperonins TCP-1
proteins.
1281BL00750F18.404.938e−25371-411BL00750Chaperonins TCP-1
proteins.
1281BL00750G20.122.324e−28432-471BL00750Chaperonins TCP-1
proteins.
1281BL00750H21.442.875e−25491-525BL00750Chaperonins TCP-1
proteins.
1281PR00304A9.205.737e−1541-57PR00304TAILLESS COMPLEX
POLYPEPTIDE 1
(CHAPERONE) SIGNATURE
1281PR00304B11.609.700e−1863-81PR00304TAILLESS COMPLEX
POLYPEPTIDE 1
(CHAPERONE) SIGNATURE
1281PR00304C8.692.575e−17 93-112PR00304TAILLESS COMPLEX
POLYPEPTIDE 1
(CHAPERONE) SIGNATURE
1281PR00304D11.044.405e−17374-396PR00304TAILLESS COMPLEX
POLYPEPTIDE 1
(CHAPERONE) SIGNATURE
1281PR00304E7.799.217e−13408-420PR00304TAILLESS COMPLEX
POLYPEPTIDE 1
(CHAPERONE) SIGNATURE
1282BL0019412.163.813e−1547-59BL00194Thioredoxin family
proteins.
1282BL0019412.164.857e−16182-194BL00194Thioredoxin family
proteins.
1282PR00421A10.154.000e−1046-54PR00421THIOREDOXIN FAMILY
SIGNATURE
1282PR00421A10.154.857e−10181-189PR00421THIOREDOXIN FAMILY
SIGNATURE
1282PR00421B11.403.348e−12189-198PR00421THIOREDOXIN FAMILY
SIGNATURE
1282PR00421B11.409.379e−1154-63PR00421THIOREDOXIN FAMILY
SIGNATURE
1282PR00421C13.605.714e−10233-244PR00421THIOREDOXIN FAMILY
SIGNATURE
1283BL001428.386.625e−10559-569BL00142Neutral zinc
metallopeptidases,
zinc-binding region
proteins.
1283PF00084B9.455.500e−091370-1381PF00084Sushi domain proteins
(SCR repeat proteins.
1283PR00014A8.228.773e−09687-696PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1283PR00480B15.412.286e−09554-572PR00480ASTACIN FAMILY
SIGNATURE
1284BL0029928.844.188e−19 92-143BL00299Ubiquitin domain
proteins.
1285BL000369.024.214e−13197-209BL00036bZIP transcription
factors basic domain
proteins.
1285PR00042A10.042.500e−22113-130PR00042FOS TRANSFORMING
PROTEIN SIGNATURE
1285PR00042B10.701.191e−21181-197PR00042FOS TRANSFORMING
PROTEIN SIGNATURE
1285PR00042C8.291.273e−22198-214PR00042FOS TRANSFORMING
PROTEIN SIGNATURE
1285PR00042D8.972.500e−27216-237PR00042FOS TRANSFORMING
PROTEIN SIGNATURE
1285PR00042E9.698.200e−29237-260PR00042FOS TRANSFORMING
PROTEIN SIGNATURE
1285PR00043B8.735.652e−09197-213PR00043JUN TRANSCRIPTION
FACTOR SIGNATURE
1286BL00297A17.584.375e−3731-67BL00297Heat shock hsp70
proteins family
proteins.
1286BL00297B22.914.316e−38 71-119BL00297Heat shock hsp70
proteins family
proteins.
1286BL00297C9.511.000e−40160-211BL00297Heat shock hsp70
proteins family
proteins.
1286BL00297D11.951.000e−40220-259BL00297Heat shock hsp70
proteins family
proteins.
1286BL00297E18.566.400e−35316-359BL00297Heat shock hsp70
proteins family
proteins
1286BL00297F11.841.692e−30380-407BL00297Heat shock hsp70
proteins family
proteins.
1286BL00297G21.871.000e−40412-466BL00297Heat shock hsp70
proteins family
proteins.
1286BL00297H15.461.000e−40475-528BL00297Heat shock hsp70
proteins family
proteins.
1286PR00301A14.845.846e−1729-42PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1286PR00301B15.363.118e−1657-69PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1286PR00301D15.512.227e−26168-188PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1286PR00301E8.114.789e−13228-238PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1286PR00301F13.981.857e−19355-371PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1286PR00301G13.781.000e−25387-407PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1286PR00301H8.815.909e−20412-431PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1286PR00301I12.765.500e−18493-509PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1287BL0019412.163.813e−15398-410BL00194Thioredoxin family
proteins.
1287BL0019412.165.091e−1749-61BL00194Thioredoxin family
proteins.
1287PR00421A10.151.429e−10397-405PR00421THIOREDOXIN FAMILY
SIGNATURE
1287PR00421A10.153.160e−0948-56PR00421THIOREDOXIN FAMILY
SIGNATURE
1287PR00421B11.401.000e−1356-65PR00421THIOREDOXIN FAMILY
SIGNATURE
1287PR00421B11.403.348e−12405-414PR00421THIOREDOXIN FAMILY
SIGNATURE
1287PR00421C13.605.286e−10446-457PR00421THIOREDOXIN FAMILY
SIGNATURE
1287PR00421C13.605.500e−09 96-107PR00421THIOREDOXIN FAMILY
SIGNATURE
1288BL00251A14.271.383e−10121-138BL00251TNF family proteins.
1288BL00251B11.405.200e−17171-190BL00251TNF family proteins.
1288BL00251C13.975.250e−14238-256BL00251TNF family proteins.
1288BL00251D12.031.529e−09269-280BL00251TNF family proteins.
1289BL00387A14.693.423e−1444-58BL00387Inorganic
pyrophosphatase
proteins.
1289BL00387B27.024.103e−31 72-109BL00387Inorganic
pyrophosphatase
proteins.
1289BL00387C20.601.310e−24133-163BL00387Inorganic
pyrophosphatase
proteins.
1289BL00387D21.316.786e−23167-199BL00387Inorganic
pyrophosphatase
proteins.
1290BL00115Z3.127.022e−09255-303BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1290BL00478B14.793.500e−12405-419BL00478LIM domain proteins.
1290BL00478B14.793.739e−14463-477BL00478LIM domain proteins.
1290BL00478B14.796.000e−12530-544BL00478LIM domain proteins.
1290DM00984B15.184.822e−25420-474DM00984w MYOD MYOBLAST
DETERMINATION SHORT.
1290DM00984C7.668.036e−11475-488DM00984w MYOD MYOBLAST
DETERMINATION SHORT.
1292BL00470A16.256.077e−1157-77BL00470Isocitrate and
isopropylmalate
dehydrogenases
proteins.
1292BL00470C15.434.375e−11162-176BL00470Isocitrate and
isopropylmalate
dehydrogenases
proteins.
1292BL00470D21.758.500e−13269-299BL00470Isocitrate and
isopropylmalate
dehydrogenases
proteins.
1293BL00325A24.832.125e−2661-92BL00325Actin-depolymerizing
proteins.
1293BL00325B21.661.000e−40 93-138BL00325Actin-depolymerizing
proteins.
1293PR00006A13.462.000e−3117-41PR00006COFILIN/DESTRIN FAMILY
SIGNATURE
1293PR00006B4.381.391e−2779-99PR00006COFILIN/DESTRIN FAMILY
SIGNATURE
1293PR00006C9.301.500e−28100-121PR00006COFILIN/DESTRIN FAMILY
SIGNATURE
1293PR00006D14.999.750e−21122-138PR00006COFILIN/DESTRIN FAMILY
SIGNATURE
1293PR00006E9.611.462e−14153-165PR00006COFILIN/DESTRIN FAMILY
SIGNATURE
1294BL0018328.976.586e−3350-97BL00183Ubiquitin-conjugating
enzymes proteins.
1295BL00113A12.747.508e−09 8-24BL00113Adenylate kinase
proteins.
1295BL00211A12.231.000e−09 9-20BL00211ABC transporters family
proteins.
1295BL00567A10.668.714e−09 6-24BL00567Phosphoribulokinase
proteins.
1295BL00674B4.469.392e−09 4-25BL00674AAA-protein family
proteins.
1295BL00856A17.254.176e−11 8-20BL00856Guanylate kinase
proteins.
1295BL00856B9.612.565e−2236-56BL00856Guanylate kinase
proteins.
1295BL00856C29.211.409e−38 64-111BL00856Guanylate kinase
proteins.
1295PR00449A13.203.596e−10 5-26PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1297BL00291A4.493.586e−0955-89BL00291Prion protein.
1297BL00309A19.165.065e−16125-149BL00309Vertebrate galactoside-
binding lectin
proteins.
1297BL00309B12.114.500e−16150-164BL00309Vertebrate galactoside-
binding lectin
proteins.
1297BL00309C18.651.000e−22171-195BL00309Vertebrate galactoside-
binding lectin
proteins.
1297BL00604F5.964.709e−0923-67BL00604Synaptophysin/
synaptoporin proteins.
1297DM00250B13.843.593e−1240-63DM00250kw ANNEXIN ANTIGEN
PROLINE TUMOR.
1300BL01113A17.995.091e−11 94-120BL01113C1q domain proteins.
1303BL00019A12.563.475e−1345-55BL00019Actinin-type actin-
binding domain
proteins.
1303BL00019B13.348.096e−1070-92BL00019Actinin-type actin-
binding domain
proteins.
1303BL00019B13.348.548e−161992-2014BL00019Actinin-type actin-
binding domain
proteins.
1303BL00019C14.665.171e−32118-153BL00019Actinin-type actin-
binding domain
proteins.
1303BL00019D15.332.703e−232455-2484BL00019Actinin-type actin-
binding domain
proteins.
1303BL00019F19.683.195e−15154-175BL00019Actinin-type actin-
binding domain
proteins.
1303PR00401C13.161.750e−091717-1728PR00401SH2 DOMAIN SIGNATURE
1306BL0123916.101.000e−4017-70BL01239Dynein light chain type
1 proteins.
1307BL004638.225.071e−09125-136BL00463Fungal Zn(2)-Cys(6)
binuclear cluster
domain proteins.
1309BL01207A12.219.069e−1866-81BL01207Glypicans proteins.
1309BL01207B23.693.423e−37193-238BL01207Glypicans proteins.
1309BL01207C19.089.308e−39252-287BL01207Glypicans proteins.
1309BL01207D23.235.655e−29423-457BL01207Glypicans proteins.
1309BL01207E13.707.375e−16496-512BL01207Glypicans proteins.
1310BL001428.381.857e−09210-220BL00142Neutral zinc
metallopeptidases,
zinc-binding region
proteins.
1310BL01177C17.395.333e−11712-730BL01177Anaphylatoxin domain
proteins.
1310BL01180A15.414.130e−11220-231BL01180CUB domain proteins
profile.
1310BL01180B11.583.647e−11488-498BL01180CUB domain proteins
profile.
1310BL01180B11.584.000e−09644-654BL01180CUB domain proteins
profile.
1310BL01180B11.584.750e−09800-810BL01180CUB domain proteins
profile.
1310BL01180B11.586.625e−09917-927BL01180CUB domain proteins
profile.
1310BL01180B11.588.364e−13375-385BL01180CUB domain proteins
profile.
1310BL01180C17.691.000e−10394-407BL01180CUB domain proteins
profile.
1310BL01180C17.694.500e−09936-949BL01180CUB domain proteins
profile.
1310BL01180C17.698.000e−09663-676BL01180CUB domain proteins
profile.
1310BL01187B12.042.174e−13718-733BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1310BL01187B12.046.250e−17563-578BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1310PR00010C11.164.273e−10723-733PR00010TYPE II EGF-LIKE
SIGNATURE
1310PR00480A19.403.250e−17151-169PR00480ASTACIN FAMILY
SIGNATURE
1310PR00480B15.419.143e−21205-223PR00480ASTACIN FAMILY
SIGNATURE
1310PR00480C12.531.300e−17224-241PR00480ASTACIN FAMILY
SIGNATURE
1310PR00480D14.267.545e−17263-278PR00480ASTACIN FAMILY
SIGNATURE
1310PR00480E14.966.727e−12305-318PR00480ASTACIN FAMILY
SIGNATURE
1311BL00892A18.178.412e−3027-57BL00892HIT family proteins.
1311BL00892B16.861.964e−22 93-116BL00892HIT family proteins.
1311PR00332A10.159.625e−1818-34PR00332HISTIDINE TRIAD FAMILY
SIGNATURE
1311PR00332B13.621.000e−2339-57PR00332HISTIDINE TRIAD FAMILY
SIGNATURE
1311PR00332C7.372.200e−13106-116PR00332HISTIDINE TRIAD FAMILY
SIGNATURE
1312BL00854A33.939.036e−29 64-109BL00854Proteasome B-type
subunits proteins.
1312BL00854C29.921.794e−14171-199BL00854Proteasome B-type
subunits proteins.
1312BL00854D13.762.800e−09222-231BL00854Proteasome B-type
subunits proteins.
1312PR00141A11.363.613e−1767-82PR00141PROTEASOME COMPONENT
SIGNATURE
1312PR00141B11.155.304e−14188-199PR00141PROTEASOME COMPONENT
SIGNATURE
1312PR00141C11.153.368e−10199-210PR00141PROTEASOME COMPONENT
SIGNATURE
1312PR00141D12.451.923e−12224-235PR00141PROTEASOME COMPONENT
SIGNATURE
1313BL00226A12.771.360e−1471-85BL00226Intermediate filaments
proteins.
1313BL00226B23.867.545e−17171-218BL00226Intermediate filaments
proteins.
1313BL00226C13.235.800e−13236-266BL00226Intermediate filaments
proteins.
1313BL00226D19.101.500e−30336-382BL00226Intermediate filaments
proteins.
1314DM01753B6.471.247e−09276-285DM017536 kw OSTEOBLAST MAJOR
IMMUNOGENIC MPB70.
1314DM01753B6.471.750e−13538-547DM017536 kw OSTEOBLAST MAJOR
IMMUNOGENIC MPB70.
1314DM01753B6.478.767e−09139-148DM017536 kw OSTEOBLAST MAJOR
IMMUNOGENIC MPB70.
1314DM01753C17.641.735e−09199-237DM017536 kw OSTEOBLAST MAJOR
IMMUNOGENIC MPB70.
1315BL0004612.951.000e−4036-90BL00046Histone H2A proteins.
1315PD01672F8.627.029e−0935-68PD01672+ TRANSPORT EXCHANGER
NA H TRANS.
1315PR00620A11.031.429e−2416-38PR00620HISTONE H2A SIGNATURE
1315PR00620B8.478.909e−1746-61PR00620HISTONE H2A SIGNATURE
1315PR00620C10.192.862e−1561-74PR00620HISTONE H2A SIGNATURE
1315PR00620D11.393.172e−1575-89PR00620HISTONE H2A SIGNATURE
1315PR00620E8.913.025e−12 89-101PR00620HISTONE H2A SIGNATURE
1315PR00620F7.296.226e−16102-120PR00620HISTONE H2A SIGNATURE
1317BL0018830.299.036e−32640-685BL00188Biotin-requiring
enzymes attachment site
proteins.
1317BL00189A19.585.279e−12651-685BL001892-oxo acid
dehydrogenases
acyltransferase
component lipoyl bi.
1317BL00866B36.292.286e−31234-279BL00866Carbamoyl-phosphate
synthase subdomain
proteins.
1317BL00866C23.261.621e−18320-354BL00866Carbamoyl-phosphate
synthase subdomain
proteins.
1317BL00866C23.265.034e−18 9-43BL00866Carbamoyl-phosphate
synthase subdomain
proteins.
1317PD0018710.123.118e−15188-203PD00187LIGASE BIOSYNTHESIS
SYNTHETASE.
1318BL00226B23.866.128e−09 77-124BL00226Intermediate filaments
proteins.
1318BL00326D8.761.000e−40 62-102BL00326Tropomyosins proteins.
1318BL00326D8.767.729e−09 6-46BL00326Tropomyosins proteins.
1318PR00194D9.571.300e−2317-40PR00194TROPOMYOSIN SIGNATURE
1318PR00194E8.743.250e−3073-98PR00194TROPOMYOSIN SIGNATURE
1323PD01485A12.507.250e−10129-141PD01485INITIATION FACTOR
PROTEIN TRANSLATION
BIO.
1323PD01485B23.411.333e−37211-251PD01485INITIATION FACTOR
PROTEIN TRANSLATION
BIO.
1323PD01485C20.404.600e−36257-291PD01485INITIATION FACTOR
PROTEIN TRANSLATION
BIO.
1325PR00308A5.906.918e−1145-59PR00308TYPE I ANTIFREEZE
PROTEIN SIGNATURE
1325PR00308C3.837.312e−0948-57PR00308TYPE I ANTIFREEZE
PROTEIN SIGNATURE
1325PR00456E3.069.316e−0941-55PR00456RIBOSOMAL PROTEIN P2
SIGNATURE
1326BL00464A29.419.700e−2317-53BL00464Ribosomal protein L22
proteins.
1326BL00464B28.484.960e−35106-150BL00464Ribosomal protein L22
proteins.
1328BL00854A33.934.405e−2448-93BL00854Proteasome B-type
subunits proteins.
1328BL00854C29.925.615e−12154-182BL00854Proteasome B-type
subunits proteins.
1328PR00141A11.368.800e−1151-66PR00141PROTEASOME COMPONENT
SIGNATURE
1329BL00509A14.333.400e−12520-530BL00509Ras GTPase-activating
proteins.
1329BL00509B10.284.960e−11771-781BL00509Ras GTPase-activating
proteins.
1329PF00168C27.497.375e−09653-678PF00168C2 domain proteins.
1329PR00401A14.007.075e−0920-34PR00401SH2 DOMAIN SIGNATURE
1329PR00401E14.105.235e−0984-98PR00401SH2 DOMAIN SIGNATURE
1330BL00113A12.748.338e−09223-239BL00113Adenylate kinase
proteins.
1330BL00674A16.912.636e−17184-204BL00674AAA-protein family
proteins.
1330BL00674B4.466.294e−25219-240BL00674AAA-protein family
proteins.
1330BL00674C22.603.077e−35252-294BL00674AAA-protein family
proteins.
1330BL00674D23.411.000e−40311-357BL00674AAA-protein family
proteins.
1330BL00674E15.249.143e−17389-408BL00674AAA-protein family
proteins.
1330BL00675A24.864.488e−09222-265BL00675Sigma-54 interaction
domain proteins ATP-
binding region A
proteins.
1330PR00300A9.563.318e−11222-240PR00300ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT SIGNATURE
1330PR00819B10.839.100e−10221-236PR00819CBXX/CFQX SUPERFAMILY
SIGNATURE
1330PR00830A8.419.018e−13226-245PR00830ENDOPEPTIDASE LA (LON)
SERINE PROTEASE (S16)
SIGNATURE
1330PR00918A13.767.181e−10216-236PR00918CALICIVIRUS NON-
STRUCTURAL POLYPROTEIN
FAMILY SIGNATURE
1331BL00284A15.648.714e−16 77-100BL00284Serpins proteins.
1331BL00284B17.998.091e−12176-196BL00284Serpins proteins.
1331BL00284C28.563.700e−26203-244BL00284Serpins proteins.
1331BL00284D16.347.279e−12312-338BL00284Serpins proteins.
1331BL00284E19.151.333e−17391-415BL00284Serpins proteins.
1332BL00250A21.246.000e−15211-246BL00250TGF-beta family
proteins.
1332BL00250B27.371.305e−09272-307BL00250TGF-beta family
proteins.
1339BL00831A16.125.598e−0932-60BL00831Ribosomal protein L27
proteins.
1339BL00831B21.156.348e−19 61-100BL00831Ribosomal protein L27
proteins.
1339PR00063A11.711.614e−0934-58PR00063RIBOSOMAL PROTEIN L27
SIGNATURE
1339PR00063B15.249.700e−1159-83PR00063RIBOSOMAL PROTEIN L27
SIGNATURE
1342BL00652A3.164.000e−0922-28BL00652TNFR/NGFR family
cysteine-rich region
proteins.
1342PF00084B9.454.375e−10122-133PF00084Sushi domain proteins
(SCR repeat proteins.
1342PF00084C11.253.571e−10274-283PF00084Sushi domain proteins
(SCR repeat proteins.
1349BL00113A12.749.031e−09187-203BL00113Adenylate kinase
proteins.
1349BL00516B29.101.000e−08314-356BL00516Alkylbase DNA
glycosidases alkA
family proteins.
1349BL00674A16.917.000e−15148-168BL00674AAA-protein family
proteins.
1349BL00674B4.464.000e−27183-204BL00674AAA-protein family
proteins.
1349BL00674C22.604.273e−38216-258BL00674AAA-protein family
proteins.
1349BL00674D23.416.500e−39275-321BL00674AAA-protein family
proteins.
1349BL00674E15.246.478e−16353-372BL00674AAA-protein family
proteins.
1349BL00675A24.868.538e−09186-229BL00675Sigma-54 interaction
domain proteins ATP-
binding region A
proteins.
1349PR00300A9.564.409e−11186-204PR00300ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT SIGNATURE
1349PR00819B10.831.318e−09185-200PR00819CBXX/CFQX SUPERFAMILY
SIGNATURE
1349PR00830A8.415.810e−12190-209PR00830ENDOPEPTIDASE LA (LON)
SERINE PROTEASE (S16)
SIGNATURE
1349PR00918A13.765.988e−10180-200PR00918CALICIVIRUS NON-
STRUCTURAL POLYPROTEIN
FAMILY SIGNATURE
1352BL00904A8.309.936e−09320-369BL00904Protein
prenyltransferases
alpha subunit repeat
proteins proteins.
1352DM0021519.436.464e−10304-336DM00215PROLINE-RICH PROTEIN 3.
1353BL00674A16.915.500e−13174-194BL00674AAA-protein family
proteins.
1353BL00674A16.915.696e−09 1-21BL00674AAA-protein family
proteins.
1353BL00674B4.466.500e−24209-230BL00674AAA-protein family
proteins.
1353BL00674C22.605.846e−35242-284BL00674AAA-protein family
proteins.
1353BL00674D23.411.000e−40301-347BL00674AAA-protein family
proteins.
1353BL00674E15.248.826e−16379-398BL00674AAA-protein family
proteins.
1353BL00675A24.865.613e−09212-255BL00675Sigma-54 interaction
domain proteins ATP-
binding region A
proteins.
1353PR00300A9.561.887e−10212-230PR00300ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT SIGNATURE
1353PR00819B10.831.529e−09211-226PR00819CBXX/CFQX SUPERFAMILY
SIGNATURE
1353PR00830A8.412.714e−11216-235PR00830ENDOPEPTIDASE LA (LON)
SERINE PROTEASE (S16)
SIGNATURE
1353PR00887F12.747.889e−09267-284PR00887STRUCTURE-SPECIFIC
RECOGNITION PROTEIN
SIGNATURE
1354BL006789.671.000e−08233-243BL00678Trp-Asp (WD) repeat
proteins proteins.
1354BL006789.677.158e−09184-194BL00678Trp-Asp (WD) repeat
proteins proteins.
1354PR00320A16.742.853e−1074-88PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1354PR00320A16.744.706e−1028-42PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1354PR00320A16.746.049e−09231-245PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1354PR00320B12.198.875e−09182-196PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1354PR00320C13.015.320e−1074-88PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1354PR00320C13.015.680e−1028-42PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1354PR00320C13.019.500e−12182-196PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1357BL00115Z3.128.412e−09172-220BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1357BL00412C10.286.932e−09183-216BL00412Neuromodulin (GAP-43)
proteins.
1362BL01145A13.731.000e−40 3-44BL01145Ribosomal protein L34e
proteins.
1362BL01145B14.652.636e−20 88-110BL01145Ribosomal protein L34e
proteins.
1363PR00058A16.661.375e−2620-39PR00058RIBOSOMAL PROTEIN L5
SIGNATURE
1363PR00058B8.751.529e−2743-62PR00058RIBOSOMAL PROTEIN L5
SIGNATURE
1365BL00112A22.231.000e−40 94-135BL00112ATP: guanido
phosphotransferases
proteins.
1365BL00112B15.879.217e−31155-186BL00112ATP: guanido
phosphotransferases
proteins.
1365BL00112C21.771.000e−40187-240BL00112ATP: guanido
phosphotransferases
proteins.
1365BL00112D12.221.000e−40242-286BL00112ATP: guanido
phosphotransferases
proteins.
1365BL00112E17.753.455e−37304-333BL00112ATP: guanido
phosphotransferases
proteins.
1365BL00112F21.371.000e−40350-400BL00112ATP: guanido
phosphotransferases
proteins.
1366PR00800A15.239.565e−09 99-118PR00800AROMATIC-L-AMINO-ACID
DECARBOXYLASE SIGNATURE
1367BL00213A12.959.526e−1037-50BL00213Lipocalin proteins.
1367BL00213B8.788.000e−10120-130BL00213Lipocalin proteins.
1367PR00179A13.785.680e−1037-49PR00179LIPOCALIN SIGNATURE
1367PR00179B9.561.000e−12120-132PR00179LIPOCALIN SIGNATURE
1367PR00179C19.021.000e−10148-163PR00179LIPOCALIN SIGNATURE
1369PR00050A11.285.865e−0965-80PR00050COLD SHOCK PROTEIN
SIGNATURE
1370PR00456F5.866.400e−12101-112PR00456RIBOSOMAL PROTEIN P2
SIGNATURE
1371BL0019412.169.438e−1524-36BL00194Thioredoxin family
proteins.
1371PR00421A10.152.286e−1023-31PR00421THIOREDOXIN FAMILY
SIGNATURE
1371PR00421B11.406.625e−1331-40PR00421THIOREDOXIN FAMILY
SIGNATURE
1371PR00421C13.608.615e−1270-81PR00421THIOREDOXIN FAMILY
SIGNATURE
1372BL00478B14.793.348e−14157-171BL00478LIM domain proteins.
1372BL00478B14.794.913e−1448-62BL00478LIM domain proteins.
1374BL00030B7.038.105e−0950-59BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
1377BL00154A11.865.500e−16188-205BL00154E1-E2 ATPases
phosphorylation site
proteins.
1377BL00154B15.442.800e−31332-368BL00154E1-E2 ATPases
phosphorylation site
proteins.
1377BL00154C12.386.000e−23370-388BL00154E1-E2 ATPases
phosphorylation site
proteins.
1377BL00154D12.573.769e−13508-518BL00154E1-E2 ATPases
phosphorylation site
proteins.
1377BL00154E20.378.615e−38593-633BL00154E1-E2 ATPases
phosphorylation site
proteins.
1377BL00154F8.233.813e−27712-735BL00154E1-E2 ATPases
phosphorylation site
proteins.
1377BL00154G21.189.526e−30738-771BL00154E1-E2 ATPases
phosphorylation site
proteins.
1377BL01047B19.738.000e−09721-741BL01047Heavy-metal-associated
domain proteins.
1377BL01228D17.443.684e−12713-737BL01228Hypothetical cof family
proteins.
1377PR00119A17.343.000e−15214-228PR00119P-TYPE CATION-
TRANSPORTING ATPASE
SUPERFAMILY SIGNATURE
1377PR00119B13.942.800e−20374-388PR00119P-TYPE CATION-
TRANSPORTING ATPASE
SUPERFAMILY SIGNATURE
1377PR00119C11.014.500e−12587-598PR00119P-TYPE CATION-
TRANSPORTING ATPASE
SUPERFAMILY SIGNATURE
1377PR00119D9.563.571e−13609-619PR00119P-TYPE CATION-
TRANSPORTING ATPASE
SUPERFAMILY SIGNATURE
1377PR00119E8.485.200e−24715-734PR00119P-TYPE CATION-
TRANSPORTING ATPASE
SUPERFAMILY SIGNATURE
1377PR00119F11.817.750e−13739-751PR00119P-TYPE CATION-
TRANSPORTING ATPASE
SUPERFAMILY SIGNATURE
1377PR00120C9.905.800e−19715-731PR00120H+-TRANSPORTING ATPASE
(PROTON PUMP) SIGNATURE
1377PR00121A6.719.053e−18103-117PR00121SODIUM/POTASSIUM-
TRANSPORTING ATPASE
SIGNATURE
1377PR00121B7.834.214e−26130-150PR00121SODIUM/POTASSIUM-
TRANSPORTING ATPASE
SIGNATURE
1377PR00121C9.401.000e−24294-316PR00121SODIUM/POTASSIUM-
TRANSPORTING ATPASE
SIGNATURE
1377PR00121D16.721.209e−28367-388PR00121SODIUM/POTASSIUM-
TRANSPORTING ATPASE
SIGNATURE
1377PR00121E13.974.667e−23505-523PR00121SODIUM/POTASSIUM-
TRANSPORTING ATPASE
SIGNATURE
1377PR00121F6.707.750e−27787-808PR00121SODIUM/POTASSIUM-
TRANSPORTING ATPASE
SIGNATURE
1377PR00121G6.898.875e−26854-874PR00121SODIUM/POTASSIUM-
TRANSPORTING ATPASE
SIGNATURE
1377PR00121H12.145.950e−26916-936PR00121SODIUM/POTASSIUM-
TRANSPORTING ATPASE
SIGNATURE
1377PR00121I15.478.500e−28950-974PR00121SODIUM/POTASSIUM-
TRANSPORTING ATPASE
SIGNATURE
1379PR00833H2.306.423e−09329-343PR00833POLLEN ALLERGEN POA PI
SIGNATURE
1381BL00478B14.792.800e−11279-293BL00478LIM domain proteins.
1382BL01294A5.151.571e−0923-34BL01294Uncharacterized protein
family UPF0038
proteins.
1382PR00988A6.398.500e−1720-37PR00988URIDINE KINASE
SIGNATURE
1382PR00988B11.602.915e−0957-68PR00988URIDINE KINASE
SIGNATURE
1382PR00988C13.646.108e−14104-119PR00988URIDINE KINASE
SIGNATURE
1382PR00988D5.956.878e−10160-170PR00988URIDINE KINASE
SIGNATURE
1382PR00988E8.273.872e−11174-185PR00988URIDINE KINASE
SIGNATURE
1382PR00988F12.237.828e−15196-209PR00988URIDINE KINASE
SIGNATURE
1383BL01115A10.222.768e−10 60-103BL01115GTP-binding nuclear
protein ran proteins.
1383BL01215A9.753.968e−0957-83BL01215Mrp family proteins.
1383PR00449A13.204.706e−1960-81PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1383PR00449B14.347.000e−1583-99PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1383PR00449C17.278.579e−18100-122PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1383PR00449D10.793.769e−16163-176PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1383PR00449E13.501.450e−16199-221PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1384PR00495A9.183.700e−2527-45PR00495OBESITY FACTOR (LEPTIN)
SIGNATURE
1384PR00495B10.991.099e−2447-65PR00495OBESITY FACTOR (LEPTIN)
SIGNATURE
1384PR00495C10.227.492e−2674-94PR00495OBESITY FACTOR (LEPTIN)
SIGNATURE
1384PR00495D11.963.571e−24 97-115PR00495OBESITY FACTOR (LEPTIN)
SIGNATURE
1384PR00495E13.095.114e−26118-138PR00495OBESITY FACTOR (LEPTIN)
SIGNATURE
1384PR00495F7.553.492e−24147-167PR00495OBESITY FACTOR (LEPTIN)
SIGNATURE
1384PR00495G6.741.529e−21168-183PR00495OBESITY FACTOR (LEPTIN)
SIGNATURE
1386BL00039A18.444.600e−3057-95BL00039DEAD-box subfamily ATP-
dependent helicases
proteins.
1386BL00039B19.192.200e−20 97-122BL00039DEAD-box subfamily ATP-
dependent helicases
proteins.
1386BL00039C15.632.500e−21181-204BL00039DEAD-box subfamily ATP-
dependent helicases
proteins.
1386BL00039D21.671.000e−40330-375BL00039DEAD-box subfamily ATP-
dependent helicases
proteins.
1386DM01537B21.631.786e−11304-350DM01537kw SKI2W SKI2 NUCLEOLAR
HELICASE.
1386PF002717.991.000e−08361-368PF00271Helicases conserved C-
terminal domain
proteins.
1388PD00078B13.147.600e−12141-153PD00078REPEAT PROTEIN ANK
NUCLEAR ANKYR.
1388PF00023A16.031.750e−10187-202PF00023Ank repeat proteins.
1388PF00023A16.033.250e−09148-163PF00023Ank repeat proteins.
1388PF00023B14.209.100e−12144-153PF00023Ank repeat proteins.
1390BL00492D13.235.865e−09315-351BL00492Clusterin proteins.
1390PR00497A6.925.553e−10554-571PR00497NEUTROPHIL CYTOSOL
FACTOR P40 SIGNATURE
1391BL01118A12.464.000e−1336-50BL01118Translation initiation
factor SUI1 proteins.
1391BL01118B26.759.308e−3353-90BL01118Translation initiation
factor SUI1 proteins.
1395PF0042931.087.300e−15383-432PF00429ENV polyprotein (coat
polyprotein)
1395PR00415D12.728.403e−09328-343PR00415ACONITASE FAMILY
SIGNATURE
1395PR00783F12.333.700e−09446-466PR00783MAJOR INTRINSIC PROTEIN
FAMILY SIGNATURE
1396DM01022C19.843.571e−09103-122DM01022LRR REPEAT.
1396PR00019A11.192.565e−10131-144PR00019LEUCINE-RICH REPEAT
SIGNATURE
1396PR00019B11.364.000e−11268-281PR00019LEUCINE-RICH REPEAT
SIGNATURE
1396PR00019B11.364.600e−10220-233PR00019LEUCINE-RICH REPEAT
SIGNATURE
1396PR00019B11.367.840e−09128-141PR00019LEUCINE-RICH REPEAT
SIGNATURE
1397BL0029928.841.000e−4016-67BL00299Ubiquitin domain
proteins.
1397PD01457A16.511.000e−40 77-121PD01457RIBOSOMAL PROTEIN 40S
ZINC-FINGER METAL.
1397PD01457B13.001.000e−31124-148PD01457RIBOSOMAL PROTEIN 40S
ZINC-FINGER METAL.
1397PR00348A7.862.000e−2611-31PR00348UBIQUITIN SIGNATURE
1397PR00348B5.782.800e−2732-52PR00348UBIQUITIN SIGNATURE
1397PR00348C20.031.643e−2753-74PR00348UBIQUITIN SIGNATURE
1398BL0028024.613.000e−29165-208BL00280Pancreatic trypsin
inhibitor (Kunitz)
family proteins.
1398BL0028024.614.857e−3443-86BL00280Pancreatic trypsin
inhibitor (Kunitz)
family proteins.
1398BL0028024.615.215e−10104-147BL00280Pancreatic trypsin
inhibitor (Kunitz)
family proteins.
1398PR00759A14.513.045e−1133-47PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1398PR00759A14.517.900e−09155-169PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1398PR00759B11.261.231e−09183-193PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1398PR00759B11.261.290e−1061-71PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1398PR00759C14.153.483e−13193-208PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1398PR00759C14.155.636e−1271-86PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1399BL00388A23.145.875e−40 5-50BL00388Proteasome A-type
subunits proteins.
1399BL00388B31.386.538e−29 64-105BL00388Proteasome A-type
subunits proteins.
1399BL00388C18.792.000e−22119-140BL00388Proteasome A-type
subunits proteins.
1399BL00388D20.711.391e−26147-177BL00388Proteasome A-type
subunits proteins.
1399BL00854A33.939.000e−1136-81BL00854Proteasome B-type
subunits proteins.
1399PF0022714.685.950e−0912-23PF00227Proteasome A-type and
B-type.
1401BL00113A12.749.031e−09171-187BL00113Adenylate kinase
proteins.
1401BL00674A16.914.857e−14132-152BL00674AAA-protein family
proteins.
1401BL00674B4.465.235e−25167-188BL00674AAA-protein family
proteins.
1401BL00674C22.609.308e−35200-242BL00674AAA-protein family
proteins.
1401BL00674D23.414.176e−40259-305BL00674AAA-protein family
proteins.
1401BL00674E15.248.200e−20337-356BL00674AAA-protein family
proteins.
1401PR00051A10.688.382e−09167-187PR00051BACTERIAL CHROMOSOMAL
REPLICATION INITIATOR
(DNAA) SIGNATURE
1401PR00300A9.564.682e−11170-188PR00300ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT SIGNATURE
1401PR00819B10.832.482e−09169-184PR00819CBXX/CFQX SUPERFAMILY
SIGNATURE
1401PR00830A8.419.673e−13174-193PR00830ENDOPEPTIDASE LA (LON)
SERINE PROTEASE (S16)
SIGNATURE
1403BL0028216.885.800e−09127-149BL00282Kazal serine protease
inhibitors family
proteins.
1403BL00612B11.354.600e−09169-201BL00612Osteonectin domain
proteins.
1404BL00229A23.573.591e−0960-98BL00229Tau and MAP proteins
tubulin-binding domain
proteins.
1404PR00456F5.866.400e−12102-113PR00456RIBOSOMAL PROTEIN P2
SIGNATURE
1408BL00989A11.664.000e−12 5-18BL00989Clathrin adaptor
complexes small chain
proteins.
1408BL00989B26.511.000e−40 66-116BL00989Clathrin adaptor
complexes small chain
proteins.
1408PR00317F10.905.935e−09103-117PR00317EPENDYMIN SIGNATURE
1409BL0019412.163.813e−15547-559BL00194Thioredoxin family
proteins.
1409BL0019412.166.727e−17198-210BL00194Thioredoxin family
proteins.
1409BL0019412.168.071e−1683-95BL00194Thioredoxin family
proteins.
1409PR00421A10.151.429e−10546-554PR00421THIOREDOXIN FAMILY
SIGNATURE
1409PR00421A10.153.143e−1082-90PR00421THIOREDOXIN FAMILY
SIGNATURE
1409PR00421A10.156.571e−10197-205PR00421THIOREDOXIN FAMILY
SIGNATURE
1409PR00421B11.401.783e−12205-214PR00421THIOREDOXIN FAMILY
SIGNATURE
1409PR00421B11.407.000e−1490-99PR00421THIOREDOXIN FAMILY
SIGNATURE
1409PR00421B11.407.750e−13554-563PR00421THIOREDOXIN FAMILY
SIGNATURE
1409PR00421C13.601.346e−09596-607PR00421THIOREDOXIN FAMILY
SIGNATURE
1409PR00421C13.607.231e−09248-259PR00421THIOREDOXIN FAMILY
SIGNATURE
1409PR00421C13.609.308e−09133-144PR00421THIOREDOXIN FAMILY
SIGNATURE
1410BL00567A10.666.459e−1121-39BL00567Phosphoribulokinase
proteins.
1410BL01294A5.153.872e−1222-33BL01294Uncharacterized protein
family UPF0038
proteins.
1410BL01294B7.905.065e−1246-60BL01294Uncharacterized protein
family UPF0038
proteins.
1410BL01294C22.065.219e−26 71-108BL01294Uncharacterized protein
family UPF0038
proteins.
1410BL01294E20.473.800e−23157-197BL01294Uncharacterized protein
family UPF0038
proteins.
1410PR00988A6.396.276e−1219-36PR00988URIDINE KINASE
SIGNATURE
1411BL00132A26.073.329e−0950-90BL00132zinc carboxypeptidases,
zinc-binding region 1
proteins.
1411PR00765A12.092.500e−0976-88PR00765CARBOXYPEPTIDASE A
METALLOPROTEASE (M14)
FAMILY SIGNATURE
1411PR00765B15.572.800e−12102-116PR00765CARBOXYPEPTIDASE A
METALLOPROTEASE (M14)
FAMILY SIGNATURE
1411PR00765C12.553.659e−09181-189PR00765CARBOXYPEPTIDASE A
METALLOPROTEASE (M14)
FAMILY SIGNATURE
1411PR00765D14.169.053e−11240-253PR00765CARBOXYPEPTIDASE A
METALLOPROTEASE (M14)
FAMILY SIGNATURE
1412BL0020313.945.979e−10 91-136BL00203Vertebrate
metallothioneins
proteins.
1412BL00243I31.772.521e−09503-545BL00243Integrins beta chain
cysteine-rich domain
proteins.
1412BL01177B13.616.400e−16200-215BL01177Anaphylatoxin domain
proteins.
1412BL01177C17.392.875e−20448-466BL01177Anaphylatoxin domain
proteins.
1412BL01177C17.395.286e−09492-510BL01177Anaphylatoxin domain
proteins.
1412BL01177D17.503.739e−17474-491BL01177Anaphylatoxin domain
proteins.
1412BL01177E20.641.375e−26496-5228L01177Anaphylatoxin domain
proteins.
1412BL01187A9.981.000e−12439-450BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1412BL01187A9.984.789e−11260-271BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1412BL01187A9.984.857e−10479-490BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1412BL01187A9.986.625e−09397-408BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1412BL01187A9.989.571e−10523-534BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1412BL01187A9.989.625e−09214-225BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1412BL01187B12.043.250e−14415-430BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1412BL01187B12.044.600e−10190-205BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1412BL01187B12.045.333e−12373-388BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1412BL01187B12.045.500e−09498-513BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1412BL01187B12.046.478e−13454-469BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1412PR00010A11.799.308e−09441-452PR00010TYPE II EGF-LIKE
SIGNATURE
1412PR00010C11.165.714e−09420-430PR00010TYPE II EGF-LIKE
SIGNATURE
1412PR00538B10.458.688e−09108-127PR00538MUSCARINIC M1 RECEPTOR
SIGNATURE
1412PR00907B11.299.766e−10494-510PR00907THROMBOMODULIN
SIGNATURE
1413BL00030A14.396.143e−13346-364BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
1413BL00030A14.399.000e−10260-278BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
1413BL00030B7.036.211e−09295-304BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
1413BL00030B7.038.800e−10382-391BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
1413BL00291A4.497.506e−10418-452BL00291Prion protein.
1413BL00412D16.547.245e−09130-180BL00412Neuromodulin (GAP-43)
proteins.
1414BL00054A25.719.591e−3429-69BL00054Ribosomal protein S11
proteins.
1414BL00054B16.721.000e−36106-147BL00054Ribosomal protein S11
proteins.
1416BL011998.497.923e−12124-137BL01199Ribosomal protein L1
proteins.
1418PR00019A11.197.261e−10256-269PR00019LEUCINE-RICH REPEAT
SIGNATURE
1418PR00019A11.197.600e−12186-199PR00019LEUCINE-RICH REPEAT
SIGNATURE
1418PR00019B11.363.880e−09253-266PR00019LEUCINE-RICH REPEAT
SIGNATURE
1418PR00019B11.365.000e−11183-196PR00019LEUCINE-RICH REPEAT
SIGNATURE
1419PD0021015.253.400e−15112-127PD00210PROTEIN ANTIOXIDANT
PEROXIDASE RED.
1421BL00213A12.954.316e−1040-53BL00213Lipocalin proteins.
1421PR00179A13.782.080e−1040-52PR00179LIPOCALIN SIGNATURE
1421PR00179B9.567.375e−12120-132PR00179LIPOCALIN SIGNATURE
1422BL0117119.941.000e−4030-67BL01171Ribosomal protein L21e
proteins.
1423BL00361A11.949.206e−1352-67BL00361Ribosomal protein S10
proteins.
1423BL00361B18.345.750e−2269-91BL00361Ribosomal protein S10
proteins.
1423PR00971A13.332.432e−0919-32PR00971RIBOSOMAL PROTEIN S10
FAMILY SIGNATURE
1423PR00971B11.312.742e−1354-69PR00971RIBOSOMAL PROTEIN S10
FAMILY SIGNATURE
1423PR00971C11.856.906e−1676-90PR00971RIBOSOMAL PROTEIN S10
FAMILY SIGNATURE
1424BL00050A23.719.250e−27 94-126BL00050Ribosomal protein L23
proteins.
1424BL00050B14.818.125e−12133-146BL00050Ribosomal protein L23
proteins.
1424PR00925B3.733.089e−1012-24PR00925NONHISTONE CHROMOSOMAL
PROTEIN HMG17 FAMILY
SIGNATURE
1427PR00326A8.755.979e−14245-265PR00326GTP1/OBG GTP-BINDING
PROTEIN FAMILY
SIGNATURE
1427PR00449A13.209.813e−11243-264PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1429PR00776A10.771.844e−2930-54PR00776HEMOGLOBINASE (C13)
CYSTEINE PROTEASE
SIGNATURE
1429PR00776B15.395.154e−3055-84PR00776HEMOGLOBINASE (C13)
CYSTEINE PROTEASE
SIGNATURE
1429PR00776C11.519.357e−18102-117PR00776HEMOGLOBINASE (C13)
CYSTEINE PROTEASE
SIGNATURE
1429PR00776D11.567.231e−22131-150PR00776HEMOGLOBINASE (C13)
CYSTEINE PROTEASE
SIGNATURE
1429PR00776E12.291.375e−19179-195PR00776HEMOGLOBINASE (C13)
CYSTEINE PROTEASE
SIGNATURE
1430BL00951A15.107.750e−39 2-37BL00951ER lumen protein
retaining receptor
proteins.
1430BL00951B14.233.100e−3138-68BL00951ER lumen protein
retaining receptor
proteins.
1430BL00951C19.351.000e−40 93-141BL00951ER lumen protein
retaining receptor
proteins.
1430BL00951D13.946.000e−38142-176BL00951ER lumen protein
retaining receptor
proteins.
1430PR00660A13.289.591e−21 4-23PR00660ER LUMEN PROTEIN
RETAINING RECEPTOR
SIGNATURE
1430PR00660B13.724.000e−2431-51PR00660ER LUMEN PROTEIN
RETAINING RECEPTOR
SIGNATURE
1430PR00660C11.326.211e−1752-68PR00660ER LUMEN PROTEIN
RETAINING RECEPTOR
SIGNATURE
1430PR00660D12.017.750e−26120-140PR00660ER LUMEN PROTEIN
RETAINING RECEPTOR
SIGNATURE
1430PR00660E11.353.625e−16142-156PR00660ER LUMEN PROTEIN
RETAINING RECEPTOR
SIGNATURE
1430PR00660F12.407.818e−22156-174PR00660ER LUMEN PROTEIN
RETAINING RECEPTOR
SIGNATURE
1430PR00660G11.778.500e−20184-199PR00660ER LUMEN PROTEIN
RETAINING RECEPTOR
SIGNATURE
1431BL00291A4.497.103e−0942-76BL00291Prion protein.
1431BL00420A20.421.000e−081000-1028BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.421.000e−09241-269BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.421.000e−09538-566BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.421.138e−09667-695BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.421.138e−09934-962BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.421.415e−09166-194BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.421.590e−10514-542BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.421.655e−11685-713BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.421.692e−09349-377BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.421.692e−09616-644BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.421.692e−09631-659BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.421.831e−09688-716BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.421.885e−10562-590BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.421.969e−09682-710BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.422.108e−09817-845BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.422.246e−09451-479BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.422.662e−09334-362BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.422.800e−09424-452BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.422.964e−11400-428BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.422.964e−11919-947BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.423.077e−09895-923BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.423.077e−09 94-122BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.423.215e−09478-506BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.423.361e−10163-191BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.423.361e−10781-809BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.423.423e−12328-356BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.423.508e−10853-881BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.423.631e−09304-332BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.423.769e−09712-740BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.423.908e−09487-515BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.424.323e−09751-779BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.424.462e−09640-668BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.424.541e−10115-143BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.424.738e−09415-443BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.424.877e−09190-218BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.425.015e−09319-347BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.425.091e−11787-815BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.425.569e−09322-350BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.425.582e−11550-578BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.425.846e−09244-272BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.426.016e−10172-200BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.426.073e−11208-236BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.426.400e−09226-254BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.426.538e−09448-476BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.426.607e−10193-221BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.426.607e−10628-656BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.426.677e−09136-164BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.426.727e−11256-284BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.426.754e−10778-806BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.426.902e−10901-929BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.427.369e−09301-329BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.427.369e−09493-521BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.427.508e−09154-182BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.427.646e−09439-467BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.427.646e−09952-980BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.427.750e−12460-488BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.427.873e−11583-611BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.427.923e−0948-76BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.427.923e−09865-893BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.427.923e−09922-950BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.062e−09283-311BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.062e−09637-665BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.062e−09838-866BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.200e−11595-623BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.377e−10313-341BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.377e−10397-425BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.377e−10721-749BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.525e−10517-545BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.615e−09352-380BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.615e−09406-434BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.691e−11127-155BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.754e−09373-401BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.754e−09457-485BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.754e−09475-503BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.820e−10331-359BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.855e−11913-941BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.428.892e−09292-320BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.429.031e−09427-455BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.429.031e−09565-593BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.429.031e−09910-938BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.429.262e−10253-281BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.429.446e−09856-884BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.429.509e−11100-128BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.429.509e−11874-902BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.429.585e−09799-827BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.429.723e−09376-404BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.429.723e−09481-509BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.429.852e−10106-134BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.429.852e−10238-266BL00420Speract receptor repeat
proteins domain
proteins.
1431BL00420A20.429.852e−10 91-119BL00420Speract receptor repeat
proteins domain
proteins.
1431BL01113A17.991.000e−08397-423BL01113C1q domain proteins.
1431BL01113A17.991.000e−09898-924BL01113C1q domain proteins.
1431BL01113A17.991.173e−09145-171BL01113C1q domain proteins.
1431BL01113A17.991.243e−13313-339BL01113C1q domain proteins.
1431BL01113A17.991.519e−09418-444BL01113C1q domain proteins.
1431BL01113A17.991.692e−09136-162BL01113C1q domain proteins.
1431BL01113A17.991.923e−12493-519BL01113C1q domain proteins.
1431BL01113A17.992.227e−11391-417BL01113C1q domain proteins.
1431BL01113A17.992.340e−1039-65BL01113C1q domain proteins.
1431BL01113A17.992.385e−091009-1035BL01113C1q domain proteins.
1431BL01113A17.992.385e−09910-936BL01113C1q domain proteins.
1431BL01113A17.992.532e−10304-330BL01113C1q domain proteins.
1431BL01113A17.992.558e−09289-315BL01113C1q domain proteins.
1431BL01113A17.992.846e−1245-71BL01113C1q domain proteins.
1431BL01113A17.993.077e−12190-216BL01113C1q domain proteins.
1431BL01113A17.993.250e−09382-408BL01113C1q domain proteins.
1431BL01113A17.993.250e−09478-504BL01113C1q domain proteins.
1431BL01113A17.993.423e−0951-77BL01113C1q domain proteins.
1431BL01113A17.993.423e−09799-825BL01113C1q domain proteins.
1431BL01113A17.993.769e−09808-834BL01113C1q domain proteins.
1431BL01113A17.993.769e−09 94-120BL01113C1q domain proteins.
1431BL01113A17.994.064e−10127-153BL01113C1q domain proteins.
1431BL01113A17.994.068e−1148-74BL01113C1q domain proteins.
1431BL01113A17.994.115e−09634-660BL01113C1q domain proteins.
1431BL01113A17.994.255e−10460-486BL01113C1q domain proteins.
1431BL01113A17.994.273e−11208-234BL01113C1q domain proteins.
1431BL01113A17.994.288e−09172-198BL01113C1q domain proteins.
1431BL01113A17.994.447e−10295-321BL01113C1q domain proteins.
1431BL01113A17.994.447e−10781-807BL01113C1q domain proteins.
1431BL01113A17.994.447e−10922-948BL01113C1q domain proteins.
1431BL01113A17.994.462e−09433-459BL01113C1q domain proteins.
1431BL01113A17.994.462e−09805-831BL01113C1q domain proteins.
1431BL01113A17.994.635e−09121-147BL01113C1q domain proteins.
1431BL01113A17.994.682e−11286-312BL01113C1q domain proteins.
1431BL01113A17.994.808e−09250-276BL01113C1q domain proteins.
1431BL01113A17.994.808e−09445-471BL01113C1q domain proteins.
1431BL01113A17.994.981e−09163-189BL01113C1q domain proteins.
1431BL01113A17.994.981e−09166-192BL01113C1q domain proteins.
1431BL01113A17.994.981e−09667-693BL01113C1q domain proteins.
1431BL01113A17.995.021e−101000-1026BL01113C1q domain proteins.
1431BL01113A17.995.021e−10520-546BL01113C1q domain proteins.
1431BL01113A17.995.091e−11 97-123BL01113C1q domain proteins.
1431BL01113A17.995.327e−09151-177BL01113C1q domain proteins.
1431BL01113A17.995.327e−09352-378BL01113C1q domain proteins.
1431BL01113A17.995.404e−10184-210BL01113C1q domain proteins.
1431BL01113A17.995.596e−101081-1107BL01113C1q domain proteins.
1431BL01113A17.995.596e−10469-495BL01113C1q domain proteins.
1431BL01113A17.995.596e−10856-882BL01113C1q domain proteins.
1431BL01113A17.995.615e−12640-666BL01113C1q domain proteins.
1431BL01113A17.995.673e−09148-174BL01113C1q domain proteins.
1431BL01113A17.995.673e−09865-891BL01113C1q domain proteins.
1431BL01113A17.995.705e−11106-132BL01113C1q domain proteins.
1431BL01113A17.995.865e−13193-219BL01113C1q domain proteins.
1431BL01113A17.995.979e−101054-1080BL01113C1q domain proteins.
1431BL01113A17.996.019e−09847-873BL01113C1q domain proteins.
1431BL01113A17.996.192e−09142-168BL01113C1q domain proteins.
1431BL01113A17.996.192e−09310-336BL01113C1q domain proteins.
1431BL01113A17.996.365e−09583-609BL01113C1q domain proteins.
1431BL01113A17.996.365e−09850-876BL01113C1q domain proteins.
1431BL01113A17.996.538e−09541-567BL01113C1q domain proteins.
1431BL01113A17.996.538e−0957-83BL01113C1q domain proteins.
1431BL01113A17.996.538e−12547-573BL01113C1q domain proteins.
1431BL01113A17.996.538e−12796-822BL01113C1q domain proteins.
1431BL01113A17.996.712e−09370-396BL01113C1q domain proteins.
1431BL01113A17.996.712e−09853-879BL01113C1q domain proteins.
1431BL01113A17.996.745e−10631-657BL01113C1q domain proteins.
1431BL01113A17.996.885e−09256-282BL01113C1q domain proteins.
1431BL01113A17.996.936e−10199-225BL01113C1q domain proteins.
1431BL01113A17.996.936e−10337-363BL01113C1q domain proteins.
1431BL01113A17.997.000e−121090-1116BL01113C1q domain proteins.
1431BL01113A17.997.058e−09322-348BL01113C1q domain proteins.
1431BL01113A17.997.128e−10139-165BL01113C1q domain proteins.
1431BL01113A17.997.319e−10328-354BL01113C1q domain proteins.
1431BL01113A17.997.319e−10874-900BL01113C1q domain proteins.
1431BL01113A17.997.511e−10658-684BL01113C1q domain proteins.
1431BL01113A17.997.750e−09100-126BL01113C1q domain proteins.
1431BL01113A17.997.750e−09472-498BL01113C1q domain proteins.
1431BL01113A17.997.750e−11451-477BL01113C1q domain proteins.
1431BL01113A17.997.923e−12892-918BL01113C1q domain proteins.
1431BL01113A17.998.054e−13649-675BL01113C1q domain proteins.
1431BL01113A17.998.096e−09793-819BL01113C1q domain proteins.
1431BL01113A17.998.269e−09532-558BL01113C1q domain proteins.
1431BL01113A17.998.468e−10130-156BL01113C1q domain proteins.
1431BL01113A17.998.773e−11904-930BL01113C1q domain proteins.
1431BL01113A17.998.788e−09394-420BL01113C1q domain proteins.
1431BL01113A17.998.851e−10925-951BL01113C1q domain proteins.
1431BL01113A17.998.962e−09118-144BL01113C1q domain proteins.
1431BL01113A17.998.977e−11613-639BL01113C1q domain proteins.
1431BL01113A17.999.043e−10556-582BL01113C1q domain proteins.
1431BL01113A17.999.077e−12919-945BL01113C1q domain proteins.
1431BL01113A17.999.135e−091087-1113BL01113C1q domain proteins.
1431BL01113A17.999.135e−09175-201BL01113C1q domain proteins.
1431BL01113A17.999.135e−09901-927BL01113C1q domain proteins.
1431BL01113A17.999.182e−11868-894BL01113C1q domain proteins.
1431BL01113A17.999.234e−10787-813BL01113C1q domain proteins.
1431BL01113A17.999.308e−09346-372BL01113C1q domain proteins.
1431BL01113A17.999.308e−09928-954BL01113C1q domain proteins.
1431BL01113A17.999.308e−12883-909BL01113C1q domain proteins.
1431BL01113A17.999.426e−10319-345BL01113C1q domain proteins.
1431BL01113A17.999.591e−11859-885BL01113C1q domain proteins.
1431BL01113A17.999.795e−11484-510BL01113C1q domain proteins.
1431BL01113A17.999.809e−10406-432BL01113C1q domain proteins.
1431BL01113A17.999.827e−09241-267BL01113C1q domain proteins.
1431DM01418A20.831.000e−401156-1203DM01418352 FIBRILLAR COLLAGEN
CARBOXYL-TERMINAL.
1431DM01418B22.511.000e−401253-1294DM01418352 FIBRILLAR COLLAGEN
CARBOXYL-TERMINAL.
1431DM01418C20.486.276e−391324-1365DM01418352 FIBRILLAR COLLAGEN
CARBOXYL-TERMINAL.
1431PR00049D0.001.571e−101086-1100PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1431PR00049D0.009.571e−1056-70PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1433BL002599.809.400e−14 93-103BL00259Gastrin/
cholecystokinin family
proteins.
1433PD01115A12.279.750e−12 1-23PD01115PRECURSOR AMPHIBIAN
SKIN SIGNAL.
1435PR00019B11.365.950e−10179-192PR00019LEUCINE-RICH REPEAT
SIGNATURE
1437BL00141A12.102.636e−19110-125BL00141Eukaryotic and viral
aspartyl proteases
proteins.
1437BL00141B12.147.231e−11214-225BL00141Eukaryotic and viral
aspartyl proteases
proteins.
1437BL00141C9.749.471e−09266-275BL00141Eukaryotic and viral
aspartyl proteases
proteins.
1437BL00141D6.285.154e−10310-319BL00141Eukaryotic and viral
aspartyl proteases
proteins.
1437BL00141E14.321.900e−23402-425BL00141Eukaryotic and viral
aspartyl proteases
proteins.
1437PR00792A11.544.273e−24103-123PR00792PEPSIN (A1) ASPARTIC
PROTEASE FAMILY
SIGNATURE
1437PR00792B12.784.682e−11261-274PR00792PEPSIN (A1) ASPARTIC
PROTEASE FAMILY
SIGNATURE
1437PR00792C9.101.000e−11310-321PR00792PEPSIN (A1) ASPARTIC
PROTEASE FAMILY
SIGNATURE
1437PR00792D12.745.000e−17401-416PR00792PEPSIN (A1) ASPARTIC
PROTEASE FAMILY
SIGNATURE
1438BL00420A20.421.000e−0848-76BL00420Speract receptor repeat
proteins domain
proteins.
1438BL00420A20.421.415e−09 72-100BL00420Speract receptor repeat
proteins domain
proteins.
1438BL00420A20.421.590e−10 75-103BL00420Speract receptor repeat
proteins domain
proteins.
1438BL00420A20.422.180e−1045-73BL00420Speract receptor repeat
proteins domain
proteins.
1438BL00420A20.424.109e−1133-61BL00420Speract receptor repeat
proteins domain
proteins.
1438BL00420A20.427.055e−11 84-112BL00420Speract receptor repeat
proteins domain
proteins.
1438BL00420A20.428.082e−1036-64BL00420Speract receptor repeat
proteins domain
proteins.
1438BL00420A20.429.410e−10 87-115BL00420Speract receptor repeat
proteins domain
proteins.
1438BL01113A17.991.000e−1345-71BL01113C1q domain proteins.
1438BL01113A17.991.519e−09 78-104BL01113C1q domain proteins.
1438BL01113A17.994.405e−1354-80BL01113C1q domain proteins.
1438BL01113A17.995.050e−2136-62BL01113C1q domain proteins.
1438BL01113A17.995.154e−12 81-107BL01113C1q domain proteins.
1438BL01113A17.995.655e−1633-59BL01113C1q domain proteins.
1438BL01113A17.996.538e−0930-56BL01113C1q domain proteins.
1438BL01113A17.997.818e−1439-65BL01113C1q domain proteins.
1438BL01113A17.998.085e−10 75-101BL01113C1q domain proteins.
1438BL01113A17.998.154e−1242-68BL01113C1q domain proteins.
1438BL01113A17.998.851e−10 84-110BL01113C1q domain proteins.
1438BL01113A17.999.481e−09 90-116BL01113C1q domain proteins.
1438BL01113B18.266.400e−33139-174BL01113C1q domain proteins.
1438BL01113C13.181.462e−15206-225BL01113C1q domain proteins.
1438BL01113D7.471.000e−11240-249BL01113C1q domain proteins.
1438PR00007A19.334.938e−19133-159PR00007COMPLEMENT C1Q DOMAIN
SIGNATURE
1438PR00007B14.167.429e−20160-179PR00007COMPLEMENT C1Q DOMAIN
SIGNATURE
1438PR00007C15.601.225e−15206-227PR00007COMPLEMENT C1Q DOMAIN
SIGNATURE
1438PR00007D9.646.885e−11238-248PR00007COMPLEMENT C1Q DOMAIN
SIGNATURE
1439BL01115A10.226.786e−10 6-49BL01115GTP-binding nuclear
protein ran proteins.
1439PR00449A13.203.045e−17 6-27PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1439PR00449B14.341.000e−1029-45PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1439PR00449C17.272.895e−1846-68PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1439PR00449D10.792.800e−15108-121PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1439PR00449E13.504.240e−14156-178PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1440PR00492A11.925.714e−1857-72PR00492RHO PROTEIN GDP
DISSOCIATION INHIBITOR
SIGNATURE
1440PR00492B9.776.684e−2373-91PR00492RHO PROTEIN GDP
DISSOCIATION INHIBITOR
SIGNATURE
1440PR00492C9.687.107e−21119-135PR00492RHO PROTEIN GDP
DISSOCIATION INHIBITOR
SIGNATURE
1440PR00492D14.822.350e−19136-151PR00492RHO PROTEIN GDP
DISSOCIATION INHIBITOR
SIGNATURE
1440PR00492E13.981.000e−16152-164PR00492RHO PROTEIN GDP
DISSOCIATION INHIBITOR
SIGNATURE
1440PR00492F13.707.943e−24178-195PR00492RHO PROTEIN GDP
DISSOCIATION INHIBITOR
SIGNATURE
1441BL00224A7.424.600e−2526-47BL00224Clathrin light chain
proteins.
1441BL00224B16.941.000e−40106-158BL00224Clathrin light chain
proteins.
1441BL00224C16.601.000e−40163-216BL00224Clathrin light chain
proteins.
1442PR00759B11.268.385e−0974-84PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1443BL00353A9.601.000e−40 2-50BL00353HMG1/2 proteins.
1443BL00353A9.605.661e−11 3-51BL00353HMG1/2 proteins.
1443BL00353B11.471.000e−40 78-127BL00353HMG1/2 proteins.
1443BL00353C14.831.000e−40128-174BL00353HMG1/2 proteins.
1443BL00412D16.543.939e−09165-215BL00412Neuromodulin (GAP-43)
proteins.
1443BL00412D16.544.620e−10160-210BL00412Neuromodulin (GAP-43)
proteins.
1443BL00412D16.545.776e−09162-212BL00412Neuromodulin (GAP-43)
proteins.
1443BL00412D16.546.283e−10161-211BL00412Neuromodulin (GAP-43)
proteins.
1443BL00412D16.547.061e−09159-209BL00412Neuromodulin (GAP-43)
proteins.
1443BL00412D16.547.648e−11164-214BL00412Neuromodulin (GAP-43)
proteins.
1443PR00886A10.081.643e−3040-62PR00886HIGH MOBILITY GROUP
(HMG1/HMG2) PROTEIN
SIGNATURE
1443PR00886B9.883.250e−2663-83PR00886HIGH MOBILITY GROUP
(HMG1/HMG2) PROTEIN
SIGNATURE
1443PR00886C11.843.250e−23110-128PR00886HIGH MOBILITY GROUP
(HMG1/HMG2) PROTEIN
SIGNATURE
1443PR00886D15.726.786e−24128-147PR00886HIGH MOBILITY GROUP
(HMG1/HMG2) PROTEIN
SIGNATURE
1443PR00886E8.855.101e−0963-83PR00886HIGH MOBILITY GROUP
(HMG1/HMG2) PROTEIN
SIGNATURE
1443PR00886E8.859.182e−26147-167PR00886HIGH MOBILITY GROUP
(HMG1/HMG2) PROTEIN
SIGNATURE
1444PR00690A10.869.866e−09782-800PR00690ADHESIN FAMILY
SIGNATURE
1446BL000486.396.625e−0911-37BL00048Protamine P1 proteins.
1449DM0017913.977.158e−10107-116DM00179w KINASE ALPHA ADHESION
T-CELL.
1453BL00056A28.903.769e−32 75-114BL00056Ribosomal protein S17
proteins.
1453BL00056B20.866.727e−23123-146BL00056Ribosomal protein S17
proteins.
1453PR00973A20.762.565e−20 89-112PR00973RIBOSOMAL PROTEIN S17
FAMILY SIGNATURE
1453PR00973B13.276.625e−12123-133PR00973RIBOSOMAL PROTEIN S17
FAMILY SIGNATURE
1453PR00973C10.861.300e−09133-140PR00973RIBOSOMAL PROTEIN S17
FAMILY SIGNATURE
1454BL01019A13.209.520e−1346-85BL01019ADP-ribosylation
factors family
proteins.
1454BL0115A10.225.075e−1112-55BL01115GTP-binding nuclear
protein ran proteins.
1454PR00449A13.205.846e−2112-33PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1454PR00449B14.345.500e−1335-51PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1454PR00449C17.273.700e−2453-75PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1454PR00449D10.793.368e−13115-128PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1454PR00449E13.506.684e−17150-172PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1458BL00284A15.642.742e−15166-189BL00284Serpins proteins.
1458BL00284B17.996.182e−12258-278BL00284Serpins proteins.
1458BL00284C28.566.400e−25285-326BL00284Serpins proteins.
1458BL00284D16.347.070e−12396-422BL00284Serpins proteins.
1458BL00284E19.157.968e−16474-498BL00284Serpins proteins.
1458PD02080A10.039.750e−10 1-16PD02080T-CELL GLYCOPROTEIN CD8
CHAIN SURFACE ALPHA
PRE.
1458PR00743B14.958.831e−09206-226PR00743GLYCOSYL HYDROLASE
FAMILY 36 SIGNATURE
1459BL00192A11.904.857e−30 5-44BL00192Cytochrome b/b6 heme-
ligand proteins.
1459BL00192B9.131.000e−40 62-107BL00192Cytochrome b/b6 heme-
ligand proteins.
1459BL00192C7.849.325e−40124-171BL00192Cytochrome b/b6 heme-
ligand proteins.
1459BL00192D10.294.176e−36196-231BL00192Cytochrome b/b6 heme-
ligand proteins.
1459BL00192E13.291.000e−40247-294BL00192Cytochrome b/b6 heme-
ligand proteins.
1459BL00192F14.831.900e−32318-367BL00192Cytochrome b/b6 heme-
ligand proteins.
1460BL00580A17.637.652e−3714-49BL00580Ribosomal protein L32e
proteins.
1460BL00580B19.836.850e−4050-86BL00580Ribosomal protein L32e
proteins.
1462BL00166A14.827.429e−1066-77BL00166Enoyl-CoA
hydratase/isomerase
proteins.
1462BL00166B16.923.348e−17104-125BL00166Enoyl-CoA
hydratase/isomerase
proteins.
1462BL00166C18.939.129e−23161-187BL00166Enoyl-CoA
hydratase/isomerase
proteins.
1462BL00166D22.874.375e−22213-248BL00166Enoyl-CoA
hydratase/isomerase
proteins.
1463BL00226A12.772.080e−1483-97BL00226Intermediate filaments
proteins.
1463BL00226B23.865.050e−38183-230BL00226Intermediate filaments
proteins.
1463BL00226C13.236.850e−25248-278BL00226Intermediate filaments
proteins.
1463BL00226D19.101.000e−40349-395BL00226Intermediate filaments
proteins.
1463BL00226D19.109.100e−09296-342BL00226Intermediate filaments
proteins.
1464BL00039A18.441.871e−2321-59BL00039DEAD-box subfamily ATP-
dependent helicases
proteins.
1464BL00039B19.194.064e−11277-302BL00039DEAD-box subfamily ATP-
dependent helicases
proteins.
1464BL00039C15.631.720e−11364-387BL00039DEAD-box subfamily ATP-
dependent helicases
proteins.
1464BL00039D21.671.900e−29568-613BL00039DEAD-box subfamily ATP-
dependent helicases
proteins.
1465BL00222B11.094.420e−1060-75BL00222Insulin-like growth
factor binding
proteins.
1465BL0027312.248.286e−0964-76BL00273Heat-stable
enterotoxins proteins.
1465BL0028216.884.234e−12111-133BL00282Kazal serine protease
inhibitors family
proteins.
1465PR00290B9.784.326e−09122-133PR00290KAZAL-TYPE SERINE
PROTEASE INHIBITOR
SIGNATURE
1465PR00834A9.803.659e−11213-225PR00834HTRA/DEGQ PROTEASE
FAMILY SIGNATURE
1465PR00834B10.095.500e−14234-254PR00834HTRA/DEGQ PROTEASE
FAMILY SIGNATURE
1465PR00834C15.433.613e−20275-299PR00834HTRA/DEGQ PROTEASE
FAMILY SIGNATURE
1465PR00834D12.146.455e−18313-330PR00834HTRA/DEGQ PROTEASE
FAMILY SIGNATURE
1465PR00834E13.635.355e−13335-352PR00834HTRA/DEGQ PROTEASE
FAMILY SIGNATURE
1465PR00834F10.919.526e−12427-439PR00834HTRA/DEGQ PROTEASE
FAMILY SIGNATURE
1466PR00939A8.952.636e−09135-144PR00939C2HC-TYPE ZINC-FINGER
SIGNATURE
1466PR00939A8.958.714e−11 96-105PR00939C2HC-TYPE ZINC-FINGER
SIGNATURE
1466PR00939B13.272.588e−0981-89PR00939C2HC-TYPE ZINC-FINGER
SIGNATURE
1467BL00288A17.473.333e−3417-46BL00288Tissue inhibitors of
metalloproteinases
proteins.
1467BL00288B9.445.500e−1462-72BL00288Tissue inhibitors of
metalloproteinases
proteins.
1467BL00288C14.623.829e−1678-92BL00288Tissue inhibitors of
metalloproteinases
proteins.
1467BL00288D25.761.000e−40100-144BL00288Tissue inhibitors of
metalloproteinases
proteins.
1467BL00288E17.244.333e−26145-167BL00288Tissue inhibitors of
metalloproteinases
proteins.
1468PR00450C12.224.214e−11 98-119PR00450RECOVERIN FAMILY
SIGNATURE
1469DM01282A17.377.179e−1062-83DM01282w INTEGRASE CP4-57 SYT
P4.
1470BL00359A20.664.000e−21106-141BL00359Ribosomal protein L11
proteins.
1470BL00359B23.074.231e−24142-182BL00359Ribosomal protein L11
proteins.
1470BL00359C22.186.586e−22197-230BL00359Ribosomal protein L11
proteins.
1470BL01108A20.331.000e−08126-158BL01108Ribosomal protein L24
proteins.
1472BL0039027.441.000e−4016-70BL00390Sodium and potassium
ATPases beta subunits
proteins.
1473BL00536A14.171.000e−40449-490BL00536Ubiquitin-activating
enzyme proteins.
1473BL00536A14.179.647e−1153-94BL00536Ubiquitin-activating
enzyme proteins.
1473BL00536B18.171.000e−40498-541BL00536Ubiquitin-activating
enzyme proteins.
1473BL00536B18.173.947e−09 97-140BL00536Ubiquitin-activating
enzyme proteins.
1473BL00536C15.911.000e−40559-597BL00536Ubiquitin-activating
enzyme proteins.
1473BL00536D22.911.000e−40621-664BL00536Ubiquitin-activating
enzyme proteins.
1473BL00536E16.943.753e−09744-774BL00536Ubiquitin-activating
enzyme proteins.
1473BL00536E16.948.435e−34841-871BL00536Ubiquitin-activating
enzyme proteins.
1473BL00536F13.651.000e−40872-910BL00536Ubiquitin-activating
enzyme proteins.
1476BL00227A24.553.250e−39 1-34BL00227Tubulin subunits alpha,
beta, and gamma
proteins.
1476BL00227B19.291.000e−40 50-104BL00227Tubulin subunits alpha,
beta, and gamma
proteins.
1476BL00227C25.481.000e−40111-162BL00227Tubulin subunits alpha,
beta, and gamma
proteins.
1476BL00227D18.461.000e−40220-273BL00227Tubulin subunits alpha,
beta, and gamma
proteins.
1476BL00227E24.158.500e−34324-358BL00227Tubulin subunits alpha,
beta, and gamma
proteins.
1476BL00227F21.161.000e−40372-425BL00227Tubulin subunits alpha,
beta, and gamma
proteins.
1477PD01443B15.021.000e−4020-70PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443C9.453.455e−40 78-112PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443D8.368.031e−26113-134PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443E9.221.273e−34136-162PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443F13.861.000e−40163-213PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443G11.151.000e−40228-272PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443H11.913.032e−31273-298PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443H11.916.032e−11552-577PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443H11.918.835e−13415-440PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443I10.251.000e−40299-335PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443J4.111.545e−15523-556PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443J4.112.756e−40386-419PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443J4.115.425e−10243-276PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443K9.191.000e−40420-458PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443K9.193.571e−23278-316PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443K9.199.914e−15557-595PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443L14.601.000e−40459-501PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443M11.281.000e−40521-554PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443M11.287.387e−09241-274PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443M11.287.861e−14384-417PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443N11.761000e−40555-592PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443N11.764.744e−09142-179PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443N11.767.341e−19418-455PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443N11.769.563e−14276-313PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1477PD01443O6.254.600e−33640-667PD01443INHIBITOR CALPAIN
CALPASTATIN REPEAT
THIOL PROT.
1479PR00318C12.098.254e−09268-285PR00318ALPHA G-PROTEIN
(TRANSDUCIN) SIGNATURE
1479PR00440C9.547.000e−09268-285PR00440G-PROTEIN ALPHA SUBUNIT
GROUP 12 SIGNATURE
1480BL00719A16.666.885e−1232-45BL00719Glycosyl hydrolases
family 2 proteins.
1480BL00719B17.245.333e−22207-231BL00719Glycosyl hydrolases
family 2 proteins.
1480BL00719C30.443.000e−37324-368BL00719Glycosyl hydrolases
family 2 proteins.
1480BL00719D22.904.103e−37369-406BL00719Glycosyl hydrolases
family 2 proteins.
1480BL00719E16.222.909e−18436-451BL00719Glycosyl hydrolases
family 2 proteins.
1480BL00719F17.715.765e−14533-548BL00719Glycosyl hydrolases
family 2 proteins.
1480BL00719G25.304.000e−23588-617BL00719Glycosyl hydrolases
family 2 proteins.
1480PR00132A13.458.541e−13126-141PR00132GLYCOSYL HYDROLASE
FAMILY 2 SIGNATURE
1480PR00132B10.722.688e−18338-352PR00132GLYCOSYL HYDROLASE
FAMILY 2 SIGNATURE
1480PR00132C18.685.500e−20369-387PR00132GLYCOSYL HYDROLASE
FAMILY 2 SIGNATURE
1480PR00132D16.769.036e−19437-452PR00132GLYCOSYL HYDROLASE
FAMILY 2 SIGNATURE
1480PR00132E20.168.054e−14534-549PR00132GLYCOSYL HYDROLASE
FAMILY 2 SIGNATURE
1481BL006789.671.947e−09423-433BL00678Trp-Asp (WD) repeat
proteins proteins.
1481PF00646A14.378.594e−09237-250PF00646F-box domain proteins.
1481PR00320A16.742.059e−10421-435PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1481PR00320A16.743.382e−10513-527PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1481PR00320B12.194.857e−10421-435PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1481PR00320C13.017.480e−10421-435PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1481PR00320C13.017.900e−09513-527PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1483BL01115A10.221.000e−4011-54BL01115GTP-binding nuclear
protein ran proteins.
1483BL01115B10.811.000e−40 91-134BL01115GTP-binding nuclear
protein ran proteins.
1483BL01115C10.522.200e−39140-170BL01115GTP-binding nuclear
protein ran proteins.
1483BL01115D14.491.360e−28184-215BL01115GTP-binding nuclear
protein ran proteins.
1483PR00442A6.468.013e−0912-27PR00442G-PROTEIN ALPHA SUBUNIT
GROUP Q SIGNATURE
1483PR00449A13.201.000e−1611-32PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1483PR00449B14.345.320e−1034-50PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1483PR00449C17.274.750e−1652-74PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1483PR00449D10.799.053e−13113-126PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1483PR00449E13.501.391e−15146-168PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1483PR00627A10.811.265e−1924-38PR00627GTP-BINDING NUCLEAR
PROTEIN RAN/TC4 FAMILY
SIGNATURE
1483PR00627B11.056.538e−2571-89PR00627GTP-BINDING NUCLEAR
PROTEIN RAN/TC4 FAMILY
SIGNATURE
1483PR00627C11.689.400e−29 91-112PR00627GTP-BINDING NUCLEAR
PROTEIN RAN/TC4 FAMILY
SIGNATURE
1483PR00627D12.541.000e−21127-145PR00627GTP-BINDING NUCLEAR
PROTEIN RAN/TC4 FAMILY
SIGNATURE
1483PR00627E14.591.529e−24165-187PR00627GTP-BINDING NUCLEAR
PROTEIN RAN/TC4 FAMILY
SIGNATURE
1484BL00290A20.896.143e−17140-162BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1484BL00290B13.174.750e−16197-214BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1484PF00969A22.079.719e−3311-53PF00969Class II
histocompatibility
antigen, beta domain
proteins.
1484PF00969B9.971.000e−4055-90PF00969Class II
histocompatibility
antigen, beta domain
proteins.
1484PF00969C27.721.000e−40 94-143PF00969Class II
histocompatibility
antigen, beta domain
proteins.
1484PF00969D14.027.375e−35151-180PF00969Class II
histocompatibility
antigen, beta domain
proteins.
1484PF00969E11.497.686e−35209-243PF00969Class II
histocompatibility
antigen, beta domain
proteins.
1486BL00309C18.652.241e−0962-86BL00309Vertebrate galactoside-
binding lectin
proteins.
1487BL00824B9.213.676e−09349-368BL00824Elongation factor 1
beta/beta′/delta chain
proteins.
1487PF00956A11.881.000e−13121-131PF00956Nuclesosome assembly
protein (NAP).
1487PF00956B23.141.000e−40162-202PF00956Nuclesosome assembly
protein (NAP).
1487PF00956C7.726.850e−22216-233PF00956Nuclesosome assembly
protein (NAP).
1487PF00956D7.513.700e−12295-305PF00956Nuclesosome assembly
protein (NAP).
1488BL00284A15.641.000e−1850-73BL00284Serpins proteins.
1488BL00284B17.991.273e−12149-169BL00284Serpins proteins.
1488BL00284C28.565.821e−27179-220BL00284Serpins proteins.
1488BL00284D16.341.500e−14291-317BL00284Serpins proteins.
1488BL00284E19.153.842e−21374-398BL00284Serpins proteins.
1489BL00420B22.673.951e−3428-82BL00420Speract receptor repeat
proteins domain
proteins.
1489BL00420C11.903.864e−10113-123BL00420Speract receptor repeat
proteins domain
proteins.
1489PR00258A11.468.054e−1624-40PR00258SPERACT RECEPTOR
SIGNATURE
1489PR00258B9.633.531e−1543-54PR00258SPERACT RECEPTOR
SIGNATURE
1489PR00258C9.054.643e−1158-68PR00258SPERACT RECEPTOR
SIGNATURE
1489PR00258D14.417.968e−15 89-103PR00258SPERACT RECEPTOR
SIGNATURE
1489PR00258E13.331.486e−13112-124PR00258SPERACT RECEPTOR
SIGNATURE
1490BL00474A9.962.800e−1546-56BL00474Ribosomal protein L3
proteins.
1490BL00474B21.727.500e−24 80-109BL00474Ribosomal protein L3
proteins.
1490BL00474C21.746.571e−34211-245BL00474Ribosomal protein L3
proteins.
1490BL00474D29.478.650e−36252-288BL00474Ribosomal protein L3
proteins.
1491BL00227A24.558.200e−36 1-34BL00227Tubulin subunits alpha,
beta, and gamma
proteins.
1491BL00227B19.291.000e−40 52-106BL00227Tubulin subunits alpha,
beta, and gamma
proteins.
1491BL00227C25.481.000e−40113-164BL00227Tubulin subunits alpha,
beta, and gamma
proteins.
1491BL00227D18.461.000e−40222-275BL00227Tubulin subunits alpha,
beta, and gamma
proteins.
1491BL00227E24.155.000e−37326-360BL00227Tubulin subunits alpha,
beta, and gamma
proteins.
1491BL00227F21.161.000e−40382-435BL00227Tubulin subunits alpha,
beta, and gamma
proteins.
1493BL000187.416.870e−09172-184BL00018EF-hand calcium-binding
domain proteins.
1493PR00049D0.009.214e−1063-77PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1494DM01111A10.805.500e−34 7-35DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111B9.441.000e−4036-72DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111C9.359.100e−35 93-121DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111D16.761.000e−40152-197DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111E17.281.000e−40238-286DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111E17.287.632e−10398-446DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111F18.226.684e−40305-340DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111G10.391.000e−40341-381DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111G10.395.376e−11181-221DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111G10.399.622e−09259-299DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111H12.571.000e−40382-423DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111I15.325.846e−36424-453DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111J19.198.941e−40454-487DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111K19.104.000e−38494-523DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111L11.933.500e−33524-551DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1494DM01111M10.678.500e−30560-583DM011114 kw PHOSPHATASE
TRANSFORMING 61K PDF1.
1495BL0131014.742.432e−29133-168BL01310ATP1G1/PLM/MAT8
family proteins.
1496BL01221A17.261.000e−22 1-28BL01221PMP-22/EMP/MP20
family proteins.
1496BL01221B13.294.818e−1234-47BL01221PMP-22/EMP/MP20
family proteins.
1496BL01221C26.202.303e−12 56-100BL01221PMP-22/EMP/MP20
family proteins.
1496BL01221C26.205.500e−33 59-103BL01221PMP-22/EMP/MP20
family proteins.
1496BL01221D13.996.276e−27139-165BL01221PMP-22/EMP/MP20
family proteins.
1497BL00094A13.036.192e−161139-1159BL00094C-5 cytosine-specific
DNA methylases
proteins.
1497BL00094B16.391.000e−141218-1233BL00094C-5 cytosine-specific
DNA methylases
proteins.
1497BL00094C9.142.800e−111260-1271BL00094C-5 cytosine-specific
DNA methylases
proteins.
1497BL00094D14.248.636e−141298-1317BL00094C-5 cytosine-specific
DNA methylases
proteins.
1497BL00094E14.458.920e−151546-1561BL00094C-5 cytosine-specific
DNA methylases
proteins.
1497BL00094F13.129.280e−101573-1582BL00094C-5 cytosine-specific
DNA methylases
proteins.
1497PF01140D15.543.407e−09212-246PF01140Matrix protein (MA),
p15.
1497PR00105A10.364.900e−131140-1156PR00105CYTOSINE-SPECIFIC DNA
METHYLTRANSFERASE
SIGNATURE
1497PR00105B12.322.800e−121259-1273PR00105CYTOSINE-SPECIFIC DNA
METHYLTRANSFERASE
SIGNATURE
1497PR00105C10.861.000e−101305-1318PR001015CYTOSINE-SPECIFIC DNA
METHYLTRANSFERASE
SIGNATURE
1498PR00801A10.744.913e−25 2-22PR00801ADRENOMEDULLIN
SIGNATURE
1498PR00801B11.341.094e−2230-46PR00801ADRENOMEDULLIN
SIGNATURE
1498PR00801C10.948.258e−2249-67PR00801ADRENOMEDULLIN
SIGNATURE
1498PR00801D13.488.463e−22 83-100PR00801ADRENOMEDULLIN
SIGNATURE
1498PR00801E9.315.829e−26103-122PR00801ADRENOMEDULLIN
SIGNATURE
1498PR00801F17.663.596e−25122-141PR00801ADRENOMEDULLIN
SIGNATURE
1498PR00801G10.721.000e−21141-157PR00801ADRENOMEDULLIN
SIGNATURE
1498PR00801H10.323.512e−19161-178PR00801ADRENOMEDULLIN
SIGNATURE
1499BL00303A21.775.000e−26 4-40BL00303S-100/ICaBP type
calcium binding
protein.
1499BL00303B26.151.900e−2948-84BL00303S-100/ICaBP type
calcium binding
protein.
1503BL0002726.434.000e−1127-69BL00027‘Homeobox’ domain
proteins.
1504BL00913B10.947.706e−11 86-101BL00913Iron-containing alcohol
dehydrogenases
proteins.
1504BL00913C7.624.375e−11136-145BL00913Iron-containing alcohol
dehydrogenases
proteins.
1504BL00913D24.208.981e−17170-203BL00913Iron-containing alcohol
dehydrogenases
proteins.
1504BL00913E21.389.203e−09269-302BL00913Iron-containing alcohol
dehydrogenases
proteins.
1506BL00298A10.971.000e−4013-57BL00298Heat shock hsp90
proteins family
proteins.
1506BL00298B15.641.000e−40 73-119BL00298Heat shock hsp90
proteins family
proteins.
1506BL00298C16.401.000e−40120-163BL00298Heat shock hsp90
proteins family
proteins.
1506BL00298D17.971.000e−40176-215BL00298Heat shock hsp90
proteins family
proteins.
1506BL00298E27.301.000e−40267-321BL00298Heat shock hsp90
proteins family
proteins.
1506BL00298F11.211.000e−40353-407BL00298Heat shock hsp90
proteins family
proteins.
1506BL00298G24.571.000e−40410-464BL00298Heat shock hsp90
proteins family
proteins.
1506BL00298H20.501.000e−40498-551BL00298Heat shock hsp90
proteins family
proteins.
1506BL00298I30.071.000e−40602-655BL00298Heat shock hsp90
proteins family
proteins.
1506PR00775A9.901.692e−2413-33PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1506PR00775B3.522.286e−2934-56PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1506PR00775C10.681.474e−19 83-100PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1506PR00775D8.911.000e−22101-118PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1506PR00775E8.061.000e−27126-148PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1506PR00775F12.767.188e−21177-194PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1506PR00775G10.645.800e−22195-213PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1507BL00223A15.597.158e−12270-303BL00223Annexins repeat
proteins domain
proteins.
1507BL00223A15.598.113e−1638-71BL00223Annexins repeat
proteins domain
proteins.
1507BL00223A15.599.625e−32110-143BL00223Annexins repeat
proteins domain
proteins.
1507BL00223B28.471.000e−40180-229BL00223Annexins repeat
proteins domain
proteins.
1507BL00223C24.791.000e−40257-311BL00223Annexins repeat
proteins domain
proteins.
1507BL00223C24.796.760e−18 97-151BL00223Annexins repeat
proteins domain
proteins.
1507PR00196A11.163.423e−15119-141PR00196ANNEXIN FAMILY
SIGNATURE
1507PR00196A11.167.136e−2347-69PR00196ANNEXIN FAMILY
SIGNATURE
1507PR00196B10.687.300e−17 87-103PR00196ANNEXIN FAMILY
SIGNATURE
1507PR00196C10.366.870e−23114-135PR00196ANNEXIN FAMILY
SIGNATURE
1507PR00196C10.367.750e−12274-295PR00196ANNEXIN FAMILY
SIGNATURE
1507PR00196D21.864.103e−25198-224PR00196ANNEXIN FAMILY
SIGNATURE
1507PR00196E9.191.333e−23278-298PR00196ANNEXIN FAMILY
SIGNATURE
1507PR00196E9.197.353e−12118-138PR00196ANNEXIN FAMILY
SIGNATURE
1507PR00196F13.892.714e−15306-321PR00196ANNEXIN FAMILY
SIGNATURE
1507PR00196G11.724.353e−09162-175PR00196ANNEXIN FAMILY
SIGNATURE
1507PR00196G11.726.000e−16322-335PR00196ANNEXIN FAMILY
SIGNATURE
1507PR00197B7.567.652e−1747-69PR00197ANNEXIN TYPE I
SIGNATURE
1507PR00197C7.502.394e−10 87-103PR00197ANNEXIN TYPE I
SIGNATURE
1507PR00197D7.502.500e−09274-295PR00197ANNEXIN TYPE I
SIGNATURE
1507PR00197D7.506.906e−18114-135PR00197ANNEXIN TYPE I
SIGNATURE
1507PR00197E11.899.077e−15198-224PR00197ANNEXIN TYPE I
SIGNATURE
1507PR00197F9.032.561e−09118-138PR00197ANNEXIN TYPE I
SIGNATURE
1507PR00197F9.039.690e−21278-298PR00197ANNEXIN TYPE I
SIGNATURE
1507PR00197H11.981.988e−09322-335PR00197ANNEXIN TYPE I
SIGNATURE
1507PR00198A10.331.818e−17 3-15PR00198ANNEXIN TYPE II
SIGNATURE
1507PR00198B8.713.842e−2947-69PR00198ANNEXIN TYPE II
SIGNATURE
1507PR00198C14.329.679e−20 87-103PR00198ANNEXIN TYPE II
SIGNATURE
1507PR00198D7.652.206e−10274-295PR00198ANNEXIN TYPE II
SIGNATURE
1507PR00198D7.654.000e−28114-135PR00198ANNEXIN TYPE II
SIGNATURE
1507PR00198E14.678.364e−35198-224PR00198ANNEXIN TYPE II
SIGNATURE
1507PR00198F7.981.082e−10254-261PR00198ANNEXIN TYPE II
SIGNATURE
1507PR00198G8.096.250e−27278-298PR00198ANNEXIN TYPE II
SIGNATURE
1507PR00198G8.098.319e−10118-138PR00198ANNEXIN TYPE II
SIGNATURE
1507PR00198H12.051.429e−18322-335PR00198ANNEXIN TYPE II
SIGNATURE
1507PR00199B6.861.971e−11119-141PR00199ANNEXIN TYPE III
SIGNATURE
1507PR00199B6.865.605e−1547-69PR00199ANNEXIN TYPE III
SIGNATURE
1507PR00199B6.868.634e−09204-226PR00199ANNEXIN TYPE III
SIGNATURE
1507PR00199C13.849.786e−09 87-103PR00199ANNEXIN TYPE III
SIGNATURE
1507PR00199D5.651.281e−17114-135PR00199ANNEXIN TYPE III
SIGNATURE
1507PR00199D5.654.931e−10274-295PR00199ANNEXIN TYPE III
SIGNATURE
1507PR00199F16.195.862e−09113-139PR00199ANNEXIN TYPE III
SIGNATURE
1507PR00199F16.197.750e−12198-224PR00199ANNEXIN TYPE III
SIGNATURE
1507PR00199G9.095.860e−10119-144PR00199ANNEXIN TYPE III
SIGNATURE
1507PR00199G9.099.645e−17279-304PR00199ANNEXIN TYPE III
SIGNATURE
1507PR00199H12.624.044e−09322-335PR00199ANNEXIN TYPE III
SIGNATURE
1507PR00200B7.395.099e−1147-69PR00200ANNEXIN TYPE IV
SIGNATURE
1507PR00200B7.399.465e−11119-141PR00200ANNEXIN TYPE IV
SIGNATURE
1507PR00200D10.017.554e−11 87-103PR00200ANNEXIN TYPE IV
SIGNATURE
1507PR00200E10.002.111e−14114-135PR00200ANNEXIN TYPE IV
SIGNATURE
1507PR00200E10.005.825e−10274-295PR00200ANNEXIN TYPE IV
SIGNATURE
1507PR00200F13.729.100e−10198-224PR00200ANNEXIN TYPE IV
SIGNATURE
1507PR00200G9.434.038e−20278-304PR00200ANNEXIN TYPE IV
SIGNATURE
1507PR00200G9.436.143e−12118-144PR00200ANNEXIN TYPE IV
SIGNATURE
1507PR00200H13.682.753e−11322-335PR00200ANNEXIN TYPE IV
SIGNATURE
1507PR00200H13.683.118e−09162-175PR00200ANNEXIN TYPE IV
SIGNATURE
1507PR00201A6.053.069e−12119-141PR00201ANNEXIN TYPE V
SIGNATURE
1507PR00201A6.056.838e−1647-69PR00201ANNEXIN TYPE V
SIGNATURE
1507PR00201D10.491.495e−12114-135PR00201ANNEXIN TYPE V
SIGNATURE
1507PR00201D10.496.940e−10274-295PR00201ANNEXIN TYPE V
SIGNATURE
1507PR00201E12.378.129e−11198-224PR00201ANNEXIN TYPE V
SIGNATURE
1507PR00201G11.021.231e−19278-304PR00201ANNEXIN TYPE V
SIGNATURE
1507PR00201G11.027.888e−12118-144PR00201ANNEXIN TYPE V
SIGNATURE
1507PR00201H12.047.413e−13322-335PR00201ANNEXIN TYPE V
SIGNATURE
1507PR00202B11.441.287e−12118-141PR00202ANNEXIN TYPE VI
SIGNATURE
1507PR00202B11.447.680e−1146-69PR00202ANNEXIN TYPE VI
SIGNATURE
1507PR00202D5.587.028e−09274-295PR00202ANNEXIN TYPE VI
SIGNATURE
1507PR00202D5.589.242e−12114-135PR00202ANNEXIN TYPE VI
SIGNATURE
1507PR00202E13.009.400e−10198-224PR00202ANNEXIN TYPE VI
SIGNATURE
1507PR00202G8.015.417e−11118-144PR00202ANNEXIN TYPE VI
SIGNATURE
1507PR00202G8.018.606e−25278-304PR00202ANNEXIN TYPE VI
SIGNATURE
1507PR00202H9.205.050e−10322-335PR00202ANNEXIN TYPE VI
SIGNATURE
1508BL0114425.071.000e−4022-73BL01144Ribosomal protein L31e
proteins.
1509PR00738A16.272.500e−20158-178PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1509PR00738B11.012.241e−18194-211PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1509PR00738C11.377.500e−26223-244PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1509PR00738D14.004.000e−21277-294PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1509PR00738E14.488.364e−16322-340PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1509PR00738F11.936.500e−15344-357PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1509PR00738G15.051.000e−19481-497PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1509PR00738H11.435.846e−18498-515PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1510BL00854A33.931.818e−26 58-103BL00854Proteasome B-type
subunits proteins.
1510BL00854C29.928.435e−19168-196BL00854Proteasome B-type
subunits proteins.
1511BL00487A8.842.125e−1230-39BL00487IMP dehydrogenase/GMP
reductase proteins.
1511BL00487B16.591.000e−4061-98BL00487IMP dehydrogenase/GMP
reductase proteins.
1511BL00487C10.908.043e−13153-165BL00487IMP dehydrogenase/GMP
reductase proteins.
1511BL00487D26.531.000e−40242-294BL00487IMP dehydrogenase/GMP
reductase proteins.
1511BL00487E16.121.000e−40299-343BL00487IMP dehydrogenase/GMP
reductase proteins.
1511BL00487F18.791.000e−40380-420BL00487IMP dehydrogenase/GMP
reductase proteins.
1511BL00487G26.829.500e−38439-480BL00487IMP dehydrogenase/GMP
reductase proteins.
1511BL00487H15.213.368e−17490-506BL00487IMP dehydrogenase/GMP
reductase proteins.
1511BL00557D17.761.297e−12361-402BL00557FMN-dependent alpha-
hydroxy acid
dehydrogenases
proteins.
1511BL00911G19.643.654e−09359-389BL00911Dihydroorotate
dehydrogenase proteins.
1513PR00019A11.194.000e−09207-220PR00019LEUCINE-RICH REPEAT
SIGNATURE
1513PR00019B11.361.720e−09230-243PR00019LEUCINE-RICH REPEAT
SIGNATURE
1513PR00019B11.369.640e−09204-217PR00019LEUCINE-RICH REPEAT
SIGNATURE
1514BL00019D15.333.520e−17818-847BL00019Actinin-type actin-
binding domain
proteins.
1514PD01351B13.724.981e−11233-258PD01351PROTEIN REPEAT
NEUROFILAMENT TRIPL.
1514PF00992A16.672.895e−09607-641PF00992Troponin.
1516BL00417A7.746.704e−13 5-32BL00417Synaptobrevin proteins.
1516BL00417B18.482.414e−1933-86BL00417Synaptobrevin proteins.
1516PR00219A8.989.156e−1310-29PR00219SYNAPTOBREVIN SIGNATURE
1518BL00191J11.376.447e−17128-149BL00191Cytochrome b5 family,
heme-binding domain
proteins.
1518BL00191K17.384.951e−27184-227BL00191Cytochrome b5 family,
heme-binding domain
proteins.
1518BL00559I13.637.366e−2158-86BL00559Eukaryotic
molybdopterin
oxidoreductases
proteins.
1518BL00559J19.639.348e−16128-179BL00559Eukaryotic
molybdopterin
oxidoreductases
proteins.
1518BL00559K13.177.563e−17201-227BL00559Eukaryotic
molybdopterin
oxidoreductases
proteins.
1518BL00559L13.601.514e−14270-287BL00559Eukaryotic
molybdopterin
oxidoreductases
proteins.
1518PR00371D14.552.313e−13180-199PR00371FLAVOPROTEIN PYRIDINE
NUCLEOTIDE CYTOCHROME
REDUCTASE SIGNATURE
1518PR00406A11.924.375e−1375-86PR00406CYTOCHROME B5 REDUCTASE
SIGNATURE
1518PR00406C13.107.750e−12141-155PR00406CYTOCHROME B5 REDUCTASE
SIGNATURE
1518PR00406D10.027.387e−19180-199PR00406CYTOCHROME B5 REDUCTASE
SIGNATURE
1518PR00406E8.379.400e−09218-229PR00406CYTOCHROME B5 REDUCTASE
SIGNATURE
1518PR00406F3.974.240e−10274-282PR00406CYTOCHROME B5 REDUCTASE
SIGNATURE
1518PR00409F12.706.612e−10180-199PR00409PHTHALATE DIOXYGENASE
REDUCTASE FAMILY
SIGNATURE
1518PR00410D12.974.676e−09180-199PR00410PHENOL HYDROXYLASE
REDUCTASE FAMILY
SIGNATURE
1519BL00297A17.581.000e−40 7-43BL00297Heat shock hsp70
proteins family
proteins.
1519BL00297B22.911.000e−4046-94BL00297Heat shock hsp70
proteins family
proteins.
1519BL00297C9.511.000e−40134-185BL00297Heat shock hsp70
proteins family
proteins.
1519BL00297D11.951.000e−40195-234BL00297Heat shock hsp70
proteins family
proteins.
1519BL00297E18.568.800e−40292-335BL00297Heat shock hsp70
proteins family
proteins.
1519BL00297F11.846.400e−29356-383BL00297Heat shock hsp70
proteins family
proteins.
1519BL00297G21.871.000e−40390-444BL00297Heat shock hsp70
proteins family
proteins.
1519BL00297H15.461.000e−40453-506BL00297Heat shock hsp70
proteins family
proteins.
1519PR00301A14.843.368e−16 5-18PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1519PR00301B15.361.692e−1733-45PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1519PR00301C8.629.609e−1055-63PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1519PR00301D15.515.500e−27142-162PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1519PR00301E8.112.286e−14203-213PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1519PR00301F13.981.429e−19331-347PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1519PR00301G13.786.143e−25363-383PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1519PR00301H8.812.421e−21390-409PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1519PR00301I12.762.125e−22471-487PR0030170 KD HEAT SHOCK
PROTEIN SIGNATURE
1520BL00960B24.479.471e−09195-239BL00960BTG1 family proteins.
1520PR00738A16.276.538e−17125-145PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1520PR00738B11.011.000e−18161-178PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1520PR00738C11.373.483e−23190-211PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1520PR00738D14.004.194e−19245-262PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1520PR00738E14.485.500e−16290-308PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1520PR00738F11.933.455e−14312-325PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1520PR00738G15.051.000e−20452-468PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1520PR00738H11.439.308e−18469-486PR00738GLYCOSYL HYDROLASE
FAMILY 20 SIGNATURE
1521BL00030B7.032.200e−10103-112BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
1522BL00540A15.068.636e−40 5-45BL00540Ferritin iron-binding
regions proteins.
1522BL00540B18.821.000e−40 96-150BL00540Ferritin iron-binding
regions proteins.
1522BL00540C13.004.649e−12161-172BL00540Ferritin iron-binding
regions proteins.
1524BL0036224.673.348e−35 88-130BL00362Ribosomal protein S15
proteins.
1525BL00406A9.951.000e−40 9-43BL00406Actins proteins.
1525BL00406B5.471.000e−40 85-139BL00406Actins proteins.
1525BL00406C6.751.000e−40144-198BL00406Actins proteins.
1525BL00406D12.581.000e−40271-325BL00406Actins proteins.
1525BL00406E8.441.000e−40328-377BL00406Actins proteins.
1525PR00190A7.241.375e−1328-37PR00190ACTIN SIGNATURE
1525PR00190B9.981.000e−1551-62PR00190ACTIN SIGNATURE
1525PR00190C11.494.789e−3063-85PR00190ACTIN SIGNATURE
1525PR00150D19.233.520e−24 86-104PR00190ACTIN SIGNATURE
1525PR00190E7.161.450e−19117-130PR00190ACTIN SIGNATURE
1525PR00190F7.801.321e−24142-161PR00190ACTIN SIGNATURE
1525PR00190G12.621.600e−21238-254PR00190ACTIN SIGNATURE
1526BL00798A14.975.200e−17 7-21BL00798Aldo/keto reductase
family proteins.
1526BL00798B16.015.500e−2835-59BL00798Aldo/keto reductase
family proteins.
1526BL00798C11.157.480e−1568-80BL00798Aldo/keto reductase
family proteins.
1526BL00798D7.655.235e−17 92-108BL00798Aldo/keto reductase
family proteins.
1526BL00798E20.321.000e−40177-214BL00798Aldo/keto reductase
family proteins.
1526BL00798F23.301.000e−40238-286BL00798Aldo/keto reductase
family proteins.
1526PR00069A16.018.364e−2935-59PR00069ALDO-KETO REDUCTASE
SIGNATURE
1526PR00069B11.331.000e−21 95-113PR00069ALDO-KETO REDUCTASE
SIGNATURE
1526PR00069C16.034.000e−19145-162PR00069ALDO-KETO REDUCTASE
SIGNATURE
1526PR00069D19.361.529e−32181-210PR00069ALDO-KETO REDUCTASE
SIGNATURE
1526PR00069E18.146.870e−25228-252PR00069ALDO-KETO REDUCTASE
SIGNATURE
1527BL0008620.872.421e−21427-458BL00086Cytochrome P450
cysteine heme-iron
ligand proteins.
1527PR00385A14.978.448e−11306-323PR00385P450 SUPERFAMILY
SIGNATURE
1527PR00385B10.224.300e−09324-337PR00385P450 SUPERFAMILY
SIGNATURE
1527PR00385D13.114.000e−09428-437PR00385P450 SUPERFAMILY
SIGNATURE
1527PR00385E12.666.571e−09437-448PR00385P450 SUPERFAMILY
SIGNATURE
1527PR00463E17.379.542e−11315-341PR00463E-CLASS P450 GROUP I
SIGNATURE
1527PR00464E18.284.696e−09352-372PR00464E-CLASS P450 GROUP II
SIGNATURE
1527PR00464I14.649.654e−09437-460PR00464E-CLASS P450 GROUP II
SIGNATURE
1528PR00049D0.009.929e−10180-194PR00049WILM'S TUMOUR PROTEIN
SIGNATURE
1529BL006789.671.692e−1180-90BL00678Trp-Asp (WD) repeat
proteins proteins.
1529BL006789.671.947e−09167-177BL00678Trp-Asp (WD) repeat
proteins proteins.
1529BL006789.678.615e−11122-132BL00678Trp-Asp (WD) repeat
proteins proteins.
1529PR00320A16.741.439e−09207-221PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1529PR00320A16.743.143e−1378-92PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1529PR00320A16.743.382e−1031-45PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1529PR00320A16.747.207e−11165-179PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1529PR00320A16.748.560e−12120-134PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1529PR00320B12.191.257e−1031-45PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1529PR00320B12.192.174e−13120-134PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1529PR00320B12.194.484e−11165-179PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1529PR00320B12.194.825e−09207-221PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1529PR00320B12.197.231e−1278-92PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1529PR00320C13.011.000e−1078-92PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1529PR00320C13.012.800e−10120-134PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1529PR00320C13.017.000e−12207-221PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1529PR00320C13.018.043e−11165-179PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1529PR00320C13.019.700e−0931-45PR00320G-PROTEIN BETA WD-40
REPEAT SIGNATURE
1530BL0108220.375.000e−3451-90BL01082Ribosomal protein L7Ae
proteins.
1530PR00881A9.943.455e−1235-49PR00881RIBOSOMAL PROTEIN
L7A/RS6 FAMILY
SIGNATURE
1530PR00881B9.014.484e−1254-67PR00881RIBOSOMAL PROTEIN
L7A/RS6 FAMILY
SIGNATURE
1530PR00881C12.769.526e−1370-80PR00881RIBOSOMAL PROTEIN
L7A/RS6 FAMILY
SIGNATURE
1530PR00881D11.602.440e−1480-94PR00881RIBOSOMAL PROTEIN
L7A/RS6 FAMILY
SIGNATURE
1530PR00883A6.495.500e−18 8-21PR00883HIGH MOBILITY GROUP-
LIKE NUCLEAR PROTEIN
SIGNATURE
1530PR00883B8.768.364e−1921-36PR00883HIGH MOBILITY GROUP-
LIKE NUCLEAR PROTEIN
SIGNATURE
1530PR00883C8.522.000e−1438-48PR00883HIGH MOBILITY GROUP-
LIKE NUCLEAR PROTEIN
SIGNATURE
1530PR00883D13.332.200e−1682-1694PR00883HIGH MOBILITY GROUP-
LIKE NUCLEAR PROTEIN
SIGNATURE
1530PR00884D11.079.217e−1080-90PR00884RIBOSOMAL PROTEIN HS6
SIGNATURE
1531BL00296A17.205.648e−1012-65BL00296Chaperonins cpn60
proteins.
1531BL00296B15.984.115e−13 76-129BL00296Chaperonins cpn60
proteins.
1531BL00296F19.663.826e−09476-513BL00296Chaperonins cpn60
proteins.
1531BL00750A20.078.286e−3625-67BL00750Chaperonins TCP-1
proteins.
1531BL00750B16.172.000e−39 69-118BL00750Chaperonins TCP-1
proteins.
1531BL00750C25.658.579e−23152-183BL00750Chaperonins TCP-1
proteins.
1531BL00750D16.165.875e−13199-217BL00750Chaperonins TCP-1
proteins.
1531BL00750E24.598.313e−21294-330BL00750Chaperonins TCP-1
proteins.
1531BL00750F18.403.880e−29368-408BL00750Chaperonins TCP-1
proteins.
1531BL00750G20.124.300e−31429-468BL00750Chaperonins TCP-1
proteins.
1531BL00750H21.442.731e−23486-520BL00750Chaperonins TCP-1
proteins.
1531PR00298B13.597.353e−11 88-115PR0029860 KD CHAPERONIN
SIGNATURE
1531PR00304A9.203.605e−1534-50PR00304TAILLESS COMPLEX
POLYPEPTIDE 1
(CHAPERONE) SIGNATURE
1531PR00304B11.602.059e−1756-74PR00304TAILLESS COMPLEX
POLYPEPTIDE 1
(CHAPERONE) SIGNATURE
1531PR00304C8.691.250e−18 86-105PR00304TAILLESS COMPLEX
POLYPEPTIDE 1
(CHAPERONE) SIGNATURE
1531PR00304D11.049.757e−17371-393PR00304TAILLESS COMPLEX
POLYPEPTIDE 1
(CHAPERONE) SIGNATURE
1531PR00304E7.798.043e−13405-417PR00304TAILLESS COMPLEX
POLYPEPTIDE 1
(CHAPERONE) SIGNATURE
1532BL00021B13.332.435e−10487-504BL00021Kringle domain
proteins.
1532BL00021D24.561.105e−09656-697BL00021Kringle domain
proteins.
1532BL00022B7.549.100e−09174-180BL00022EGF-like domain
proteins.
1532BL00134A11.965.114e−14487-503BL00134Serine proteases,
trypsin family,
histidine proteins.
1532BL00134B15.993.382e−13648-671BL00134Serine proteases,
trypsin family,
histidine proteins.
1532BL00134C13.455.500e−12684-697BL00134Serine proteases,
trypsin family,
histidine proteins.
1532BL00495013.756.040e−09675-703BL00495Apple domain proteins.
1532BL01187B12.046.538e−16165-180BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1532BL01253G11.345.382e−11647-660BL01253Type I fibronectin
domain proteins.
1532BL01253H13.159.587e−09666-700BL01253Type I fibronectin
domain proteins.
1532PR00010C11.163.571e−09170-180PR00010TYPE II EGF-LIKE
SIGNATURE
1532PR00722A12.278.258e−13488-503PR00722CHYMOTRYPSIN SERINE
PROTEASE FAMILY (S1)
SIGNATURE
1532PR00722B12.513.625e−09553-567PR00722CHYMOTRYPSIN SERINE
PROTEASE FAMILY (S1)
SIGNATURE
1532PR00722C10.878.105e−12647-659PR00722CHYMOTRYPSIN SERINE
PROTEASE FAMILY (S1)
SIGNATURE
1533BL00021B13.335.431e−11460-477BL00021Kringle domain
proteins.
1533BL00134A11.964.094e−15460-476BL00134Serine proteases,
trypsin family,
histidine proteins.
1533BL00134B15.995.378e−12626-649BL00134Serine proteases,
trypsin family,
histidine proteins.
1533BL00134C13.455.125e−12662-675BL00134Serine proteases,
trypsin family,
histidine proteins.
1533BL00495K12.584.845e−09462-494BL00495Apple domain proteins.
1533BL01180B11.582.875e−0965-75BL01180CUB domain proteins
profile.
1533BL01187B12.049.550e−14147-162BL01187Calcium-binding EGF-
like domain proteins
pattern proteins.
1533BL01253D4.847.960e−09460-473BL01253Type I fibronectin
domain proteins.
1533PF00084B9.458.875e−10379-390PF00084Sushi domain proteins
(SCR repeat proteins.
1533PR00722A12.277.120e−15461-476PR00722CHYMOTRYPSIN SERINE
PROTEASE FAMILY (S1)
SIGNATURE
1533PR00722B12.516.625e−12525-539PR00722CHYMOTRYPSIN SERINE
PROTEASE FAMILY (S1)
SIGNATURE
1533PR00722C10.873.864e−11625-637PR00722CHYMOTRYPSIN SERINE
PROTEASE FAMILY (S1)
SIGNATURE
1533PR00907B11.298.364e−10143-159PR00907THROMBOMODULIN
SIGNATURE
1535BL000187.411.000e−0957-69BL00018EF-hand calcium-binding
domain proteins.
1535BL000187.413.400e−12130-142BL00018EF-hand calcium-binding
domain proteins.
1535BL00303B26.156.344e−1045-81BL00303S-100/ICaBP type
calcium binding
protein.
1535PR00450C12.224.480e−10 89-110PR00450RECOVERIN FAMILY
SIGNATURE
1535PR00450C12.225.320e−1016-37PR00450RECOVERIN FAMILY
SIGNATURE
1535PR00450C12.226.520e−1052-73PR00450RECOVERIN FAMILY
SIGNATURE
1536BL00319C17.129.289e−09383-416BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1536BL00412D16.542.565e−10364-414BL00412Neuromodulin (GAP-43)
proteins.
1536BL00412D16.542.929e−09350-400BL00412Neuromodulin (GAP-43)
proteins.
1536BL00412D16.544.398e−09348-398BL00412Neuromodulin (GAP-43)
proteins.
1536BL00412D16.548.714e−09354-404BL00412Neuromodulin (GAP-43)
proteins.
1536BL00412D16.549.265e−09339-389BL00412Neuromodulin (GAP-43)
proteins.
1536BL00422C16.181.176e−09384-411BL00422Granins proteins.
1536BL00422C16.188.059e−09376-403BL00422Granins proteins.
1536BL00803A14.832.688e−1435-48BL00803Calreticulin family
proteins.
1536BL00803B17.088.714e−1863-81BL00803Calreticulin family
proteins.
1536BL00803C11.136.063e−26 91-113BL00803Calreticulin family
proteins.
1536BL00803D16.081.000e−15128-138BL00803Calreticulin family
proteins.
1536BL00803E16.552.588e−31166-196BL00803Calreticulin family
proteins.
1536BL00803F10.952.000e−37225-255BL00803Calreticulin family
proteins.
1536BL00803F10.952.179e−11191-221BL00803Calreticulin family
proteins.
1536BL00803F10.957.268e−22208-238BL00803Calreticulin family
proteins.
1536BL00803F10.959.516e−9242-272BL00803Calreticulin family
1536BL00803G14.331.000e−40258-302BL00803Calreticulin family
proteins.
1536BL00803G14.331.127e−19244-288BL00803Calreticulin family
proteins.
1536BL00803G14.337.429e−16272-316BL00803Calreticulin family
proteins.
1536BL00803H16.024.000e−10309-325BL00803Calreticulin family
proteins.
1536BL00803H16.027.375e−14337-353BL00803Calreticulin family
proteins.
1536PD00301B5.496.538e−09371-381PD00301PROTEIN REPEAT MUSCLE
CALCIUM-BI.
1536PF00992A16.678.986e−10363-397PF00992Troponin.
1536PR00626A14.351.500e−18100-118PR00626CALRETICULIN SIGNATURE
1536PR00626B14.122.200e−20126-142PR00626CALRETICULIN SIGNATURE
1536PR00626C9.707.882e−14232-245PR00626CALRETICULIN SIGNATURE
1536PR00626C9.709.100e−18215-228PR00626CALRETICULIN SIGNATURE
1536PR00626D8.306.520e−09208-230PR00626CALRETICULIN SIGNATURE
1536PR00626D8.308.017e−13256-278PR00626CALRETICULIN SIGNATURE
1536PR00626D8.308.071e−30242-264PR00626CALRETICULIN SIGNATURE
1536PR00626E11.303.676e−19266-285PR00626CALRETICULIN SIGNATURE
1536PR00626E11.307.632e−24280-299PR00626CALRETICULIN SIGNATURE
1536PR00626F15.795.500e−21313-333PR00626CALRETICULIN SIGNATURE
1537BL00303A21.775.286e−30 4-40BL00303S-100/ICaBP type
calcium binding
protein.
1537BL00303B26.151.000e−2951-87BL00303S-100/ICaBP type
calcium binding
protein.
1538BL00983A5.847.261e−1012-20BL00983Ly-6/u-PAR domain
proteins.
1538BL00983B8.191.643e−1222-31BL00983Ly-6/u-PAR domain
proteins.
1538BL00983C12.693.500e−1580-95BL00983Ly-6/u-PAR domain
proteins.
1539BL00261A23.975.500e−3429-62BL00261Glycoprotein hormones
beta chain proteins.
1539BL00261B25.646.885e−37 77-120BL00261Glycoprotein hormones
beta chain proteins.
1539PR00438A13.541.000e−0950-59PR00438GROWTH FACTOR CYSTINE
KNOT SUPERFAMILY
SIGNATURE
1540BL0028024.611.391e−37132-175BL00280Pancreatic trypsin
inhibitor (Kunitz)
family proteins.
1540BL0028024.612.241e−33 61-104BL00280Pancreatic trypsin
inhibitor (Kunitz)
family proteins.
1540BL0028024.613.500e−29224-267BL00280Pancreatic trypsin
inhibitor (Kunitz)
family proteins.
1540PR00759A14.515.500e−11122-136PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1540PR00759A14.518.579e−1251-65PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1540PR00759B11.261.692e−1179-89PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1540PR00759B11.262.385e−11150-160PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1540PR00759B11.268.269e−11242-252PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1540PR00759C14.151.000e−13 89-104PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1540PR00759C14.151.818e−15160-175PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1540PR00759C14.153.727e−12252-267PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1541BL01104A14.651.000e−4013-51BL01104Ribosomal protein L13e
proteins.
1541BL01104B15.121.000e−40 83-129BL01104Ribosomal protein L13e
proteins.
1541BL01104C15.149.550e−28174-201BL01104Ribosomal protein L13e
proteins.
1543BL01031A10.554.429e−0919-28BL01031Heat shock hsp20
proteins family
profile.
1543BL01031B15.785.200e−1973-93BL01031Heat shock hsp20
proteins family
profile.
1543BL01031C17.688.412e−21101-125BL01031Heat shock hsp20
proteins family
profile.
1543PR00299A13.538.448e−16 2-14PR00299ALPHA CRYSTALLIN
SIGNATURE
1543PR00299B17.531.000e−1619-31PR00299ALPHA CRYSTALLIN
SIGNATURE
1543PR00299C8.472.317e−2069-89PR00299ALPHA CRYSTALLIN
SIGNATURE
1543PR00299D8.565.974e−16 91-104PR00299ALPHA CRYSTALLIN
SIGNATURE
1543PR00299E12.266.455e−25106-125PR00299ALPHA CRYSTALLIN
SIGNATURE
1543PR00299F13.209.289e−21128-149PR00299ALPHA CRYSTALLIN
SIGNATURE
1543PR00299G5.584.825e−16156-171PR00299ALPHA CRYSTALLIN
SIGNATURE
1544BL01101A16.071.000e−40 9-53BL01101Casein kinase II
regulatory subunit
proteins.
1544BL01101B10.949.000e−3172-96BL01101Casein kinase II
regulatory subunit
proteins.
1544BL01101C15.368.714e−37 97-126BL01101Casein kinase II
regulatory subunit
proteins.
1544BL01101D16.871.000e−40127-168BL01101Casein kinase II
regulatory subunit
proteins.
1544PR00472A8.037.600e−23 8-24PR00472CASEIN KINASE II
REGULATORY SUBUNIT
FAMILY SIGNATURE
1544PR00472B14.841.000e−1925-39PR00472CASEIN KINASE II
REGULATORY SUBUNIT
FAMILY SIGNATURE
1544PR00472C12.385.154e−28 80-101PR00472CASEIN KINASE II
REGULATORY SUBUNIT
FAMILY SIGNATURE
1544PR00472D10.364.857e−28105-126PR00472CASEIN KINASE II
REGULATORY SUBUNIT
FAMILY SIGNATURE
1544PR00472E13.853.769e−27127-148PR00472CASEIN KINASE II
REGULATORY SUBUNIT
FAMILY SIGNATURE
1544PR00472F9.763.368e−23155-172PR00472CASEIN KINASE II
REGULATORY SUBUNIT
FAMILY SIGNATURE
1545BL0002324.314.545e−27382-418BL00023Type II fibronectin
collagen-binding domain
proteins.
1545BL0002324.318.920e−33442-478BL00023Type II fibronectin
collagen-binding domain
proteins.
1545BL01253A20.334.720e−09589-617BL01253Type I fibronectin
domain proteins.
1545PR00012A9.681.450e−14221-232PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00012A9.683.250e−142297-2308PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00012A9.684.250e−13596-607PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00012A9.684.789e−0985-96PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00012A9.687.316e−09174-185PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00012A9.688.269e−10266-277PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00012B8.281.957e−10572-580PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00012B8.284.273e−122317-2325PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00012B8.285.021e−10105-113PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00012B8.285.909e−12525-533PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00012B8.286.339e−09196-204PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00012B8.286.707e−112274-2282PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00012B8.288.475e−09287-295PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00012B8.288.902e−11616-624PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00012B8.289.043e−10152-160PR00012FIBRONECTIN TYPE I
REPEAT SIGNATURE
1545PR00013A12.261.500e−09386-395PR00013FIBRONECTIN TYPE II
REPEAT SIGNATURE
1545PR00013A12.265.875e−12446-455PR00013FIBRONECTIN TYPE II
REPEAT SIGNATURE
1545PR00013B14.752.385e−13457-469PR00013FIBRONECTIN TYPE II
REPEAT SIGNATURE
1545PR00013C12.292.607e−18474-489PR00013FIBRONECTIN TYPE II
REPEAT SIGNATURE
1545PR00013C12.294.400e−14414-429PR00013FIBRONECTIN TYPE II
REPEAT SIGNATURE
1545PR00014A8.224.750e−111946-1955PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014A8.229.591e−091040-1049PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014B14.771.000e−081956-1966PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014B14.778.500e−09864-874PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014C15.441.391e−09797-815PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014C15.441.500e−112148-2166PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014C15.441.783e−091254-1272PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014C15.442.800e−10688-706PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014C15.442.800e−121890-1908PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014C15.444.857e−131980-1998PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014C15.446.400e−101525-1543PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014C15.446.400e−101709-1727PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014C15.446.400e−10887-905PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014C15.446.478e−091619-1637PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014C15.447.000e−111435-1453PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1545PR00014C15.448.650e−101345-1363PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1546BL0008620.871.429e−20452-483BL00086Cytochrome P450
cysteine heme-iron
ligand proteins.
1546PR00359I11.135.378e−09462-473PR00359B-CLASS P450 SIGNATURE
1546PR00385A14.977.882e−16326-343PR00385P450 SUPERFAMILY
SIGNATURE
1546PR00385C16.942.421e−10379-390PR00385P450 SUPERFAMILY
SIGNATURE
1546PR00385D13.115.000e−09453-462PR00385P450 SUPERFAMILY
SIGNATURE
1546PR00385E12.665.714e−09462-473PR00385P450 SUPERFAMILY
SIGNATURE
1546PR00408A14.695.680e−15126-141PR00408MITOCHONDRIAL P450
SIGNATURE
1546PR00408B13.004.194e−09142-152PR00408MITOCHONDRIAL P450
SIGNATURE
1546PR00408C13.235.655e−18203-221PR00408MITOCHONDRIAL P450
SIGNATURE
1546PR00408D15.445.500e−21326-343PR00408MITOCHONDRIAL P450
SIGNATURE
1546PR00408E9.474.545e−13344-357PR00408MITOCHONDRIAL P450
SIGNATURE
1546PR00408F11.331.486e−18372-390PR00408MITOCHONDRIAL P450
SIGNATURE
1546PR00408G13.179.667e−10435-443PR00408MITOCHONDRIAL P450
SIGNATURE
1546PR00408H12.371.000e−12453-462PR00408MITOCHONDRIAL P450
SIGNATURE
1546PR00408I8.492.125e−14462-473PR00408MITOCHONDRIAL P450
SIGNATURE
1546PR00463G18.249.833e−10418-442PR00463E-CLASS P450 GROUP I
SIGNATURE
1546PR00463I15.028.525e−09462-485PR00463E-CLASS P450 GROUP I
SIGNATURE
1546PR00464C18.849.000e−11315-343PR00464E-CLASS P450 GROUP II
SIGNATURE
1546PR00464E18.287.511e−11373-393PR00464E-CLASS P450 GROUP II
SIGNATURE
1546PR00464I14.646.651e−11462-485PR00464E-CLASS P450 GROUP II
SIGNATURE
1546PR00465D14.646.824e−12374-390PR00465E-CLASS P450 GROUP IV
SIGNATURE
1546PR00465F13.376.940e−11423-441PR00465E-CLASS P450 GROUP IV
SIGNATURE
1548BL00301A12.413.842e−13 9-20BL00301GTP-binding elongation
factors proteins.
1548BL00301B20.095.500e−31 90-121BL00301GTP-binding elongation
factors proteins.
1548BL00301C11.738.200e−15423-436BL00301GTP-binding elongation
factors proteins.
1548BL0088017.529.214e−09 99-148BL00880Acyl-CoA-binding
protein.
1548BL01176B8.745.547e−12 87-124BL01176Initiation factor 2
proteins.
1548PR00315A11.811.818e−15 9-22PR00315GTP-BINDING ELONGATION
FACTOR SIGNATURE
1548PR00315B11.665.800e−1068-76PR00315GTP-BINDING ELONGATION
FACTOR SIGNATURE
1548PR00315C13.857.750e−1388-98PR00315GTP-BINDING ELONGATION
FACTOR SIGNATURE
1548PR00315D10.842.895e−11104-115PR00315GTP-BINDING ELONGATION
FACTOR SIGNATURE
1548PR00315E12.293.864e−09148-157PR00315GTP-BINDING ELONGATION
FACTOR SIGNATURE
1549BL00514A11.686.885e−1240-49BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1549BL00514B16.424.000e−15150-165BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1549BL00514C17.411.000e−40206-242BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1549BL00514D15.357.000e−16251-263BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1549BL00514E14.284.000e−19272-288BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1549BL00514F11.655.091e−15304-318BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1549BL00514G15.981.947e−37351-380BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1549BL00514H14.953.368e−28390-414BL00514Fibrinogen beta and
gamma chains C-terminal
domain proteins.
1549PR00171A10.008.875e−09384-394PR00171SUGAR TRANSPORTER
SIGNATURE
1551BL00615B12.253.423e−09207-220BL00615C-type lectin domain
proteins.
1551PR00770A13.711.231e−24 2-25PR00770EOSINOPHIL MAJOR BASIC
PROTEIN SIGNATURE
1551PR00770B11.439.325e−17 88-103PR00770EOSINOPHIL MAJOR BASIC
PROTEIN SIGNATURE
1551PR00770C12.195.886e−17109-125PR00770EOSINOPHIL MAJOR BASIC
PROTEIN SIGNATURE
1551PR00770D13.828.364e−21126-142PR00770EOSINOPHIL MAJOR BASIC
PROTEIN SIGNATURE
1551PR00770E8.531.000e−22153-171PR00770EOSINOPHIL MAJOR BASIC
PROTEIN SIGNATURE
1551PR00770F13.791.250e−26172-191PR00770EOSINOPHIL MAJOR BASIC
PROTEIN SIGNATURE
1551PR00770G7.653.512e−23195-212PR00770EOSINOPHIL MAJOR BASIC
PROTEIN SIGNATURE
1552BL00213A12.958.105e−1031-44BL00213Lipocalin proteins.
1552PR00179A13.785.050e−1131-43PR00179LIPOCALIN SIGNATURE
1552PR00179B9.565.034e−11112-124PR00179LIPOCALIN SIGNATURE
1552PR00179C19.028.909e−09139-154PR00179LIPOCALIN SIGNATURE
1553BL00164A11.581.529e−2732-54BL00164Enolase proteins.
1553BL00164B16.221.000e−40 98-140BL00164Enolase proteins.
1553BL00164C15.661.000e−40144-193BL00164Enolase proteins.
1553BL00164D21.972.588e−38220-262BL00164Enolase proteins.
1553BL00164E8.809.100e−20287-301BL00164Enolase proteins.
1553BL00164F10.483.813e−39313-348BL00164Enolase proteins.
1553BL00164G12.131.000e−40380-418BL00164Enolase proteins.
1553PR00148A10.111.783e−1835-49PR00148ENOLASE SIGNATURE
1553PR00148B8.607.000e−21107-123PR00148ENOLASE SIGNATURE
1553PR00148C15.332.800e−16164-177PR00148ENOLASE SIGNATURE
1553PR00148D14.461.360e−15317-328PR00148ENOLASE SIGNATURE
1553PR00148E13.624.500e−17340-354PR00148ENOLASE SIGNATURE
1553PR00148F10.191.643e−23369-386PR00148ENOLASE SIGNATURE
1554BL0008620.874.938e−24438-469BL00086Cytochrome P450
cysteine heme-iron
ligand proteins.
1554PR00359F24.201.738e−09382-409PR00359B-CLASS P450 SIGNATURE
1554PR00359I11.133.189e−09448-459PR00359B-CLASS P450 SIGNATURE
1554PR00385A14.977.750e−18311-328PR00385P450 SUPERFAMILY
SIGNATURE
1554PR00385B10.228.650e−12329-342PR00385P450 SUPERFAMILY
SIGNATURE
1554PR00385C16.946.684e−10364-375PR00385P450 SUPERFAMILY
SIGNATURE
1554PR00385D13.111.857e−10439-448PR00385P450 SUPERFAMILY
SIGNATURE
1554PR00385E12.662.800e−11448-459PR00385P450 SUPERFAMILY
SIGNATURE
1554PR00408D15.449.211e−12311-328PR00408MITOCHONDRIAL P450
SIGNATURE
1554PR00463A11.403.659e−1072-91PR00463E-CLASS P450 GROUP I
SIGNATURE
1554PR00463B17.509.077e−12 96-117PR00463E-CLASS P450 GROUP I
SIGNATURE
1554PR00463C12.856.684e−18187-205PR00463E-CLASS P450 GROUP I
SIGNATURE
1554PR00463D14.028.875e−18300-317PR00463E-CLASS P450 GROUP I
SIGNATURE
1554PR00463E17.374.150e−25320-346PR00463E-CLASS P450 GROUP I
SIGNATURE
1554PR00463F17.631.818e−16363-381PR00463E-CLASS P450 GROUP I
SIGNATURE
1554PR00463G18.245.680e−19404-428PR00463E-CLASS P450 GROUP I
SIGNATURE
1554PR00463H12.415.154e−13438-448PR00463E-CLASS P450 GROUP I
SIGNATURE
1554PR00463I15.025.500e−20448-471PR00463E-CLASS P450 GROUP I
SIGNATURE
1554PR00464C18.844.000e−11300-328PR00464E-CLASS P450 GROUP II
SIGNATURE
1554PR00464D17.404.545e−12329-346PR00464E-CLASS P450 GROUP II
SIGNATURE
1554PR00464H13.323.423e−09435-448PR00464E-CLASS P450 GROUP II
SIGNATURE
1554PR00464I14.642.532e−10448-471PR00464E-CLASS P450 GROUP II
SIGNATURE
1554PR00465F13.373.400e−09409-427PR00465E-CLASS P450 GROUP IV
SIGNATURE
1555BL01191A15.571.000e−4013-63BL01191Ribosomal protein S3Ae
proteins.
1555BL01191B13.331.000e−40 89-139BL01191Ribosomal protein S3Ae
proteins.
1555BL01191C16.501.000e−40180-231BL01191Ribosomal protein S3Ae
proteins.
1556BL012099.312.500e−14124-136BL01209LDL-receptor class A
(LDLRA) domain
proteins.
1556BL012099.318.342e−1244-56BL01209LDL-receptor class A
(LDLRA) domain
proteins.
1556PR00261A11.026.053e−17115-136PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1556PR00261A11.027.338e−1235-56PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1556PR00261B14.122.385e−15115-136PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1556PR00261B14.129.630e−1235-56PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1556PR00261C11.375.607e−0978-99PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1556PR00261C11.378.174e−1335-56PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1556PR00261C11.378.603e−17115-136PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1556PR00261D12.471.915e−16115-136PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1556PR00261D12.475.257e−1135-56PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1556PR00261E11.083.813e−13115-136PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1556PR00261E11.088.714e−1135-56PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1556PR00261F11.576.824e−12115-136PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1556PR00261F11.577.750e−1235-56PR00261LOW DENSITY LIPOPROTEIN
(LDL) RECEPTOR
SIGNATURE
1557BL0002517.172.853e−17 89-109BL00025P-type ‘Trefoil’ domain
proteins.
1557BL00129A26.211.000e−40359-404BL00129Glycosyl hydrolases
family 31 proteins.
1557BL00129B19.193.667e−25473-499BL00129Glycosyl hydrolases
family 31 proteins.
1557BL00129C15.126.211e−32594-621BL00129Glycosyl hydrolases
family 31 proteins.
1557BL00129D16.761.000e−40632-675BL00129Glycosyl hydrolases
family 31 proteins.
1557BL00129E22.601.692e−32696-731BL00129Glycosyl hydrolases
family 31 proteins.
1557BL00129F26.191.000e−29827-864BL00129Glycosyl hydrolases
family 31 proteins.
1557BL01103H11.987.840e−09738-749BL01103Aspartate-semialdehyde
dehydrogenase proteins.
1557PR00680B10.345.359e−10 99-111PR00680P-TYPE TREFOIL DOMAIN
SIGNATURE
1558BL01033A16.942.929e−1725-46BL01033Globins profile.
1558BL01033B13.811.000e−15 93-104BL01033Globins profile.
1558PR00612D9.762.976e−1080-93PR00612ALPHA HAEMOGLOBIN
SIGNATURE
1558PR00613B9.029.270e−1025-48PR00613MYOGLOBIN SIGNATURE
1558PR00613C10.229.630e−0958-78PR00613MYOGLOBIN SIGNATURE
1558PR00814A12.941.000e−2230-46PR00814BETA HAEMOGLOBIN
SIGNATURE
1558PR00814B9.183.571e−2048-63PR00814BETA HAEMOGLOBIN
SIGNATURE
1558PR00814C9.208.615e−1972-89PR00814BETA HAEMOGLOBIN
SIGNATURE
1558PR00814D15.252.286e−0994-99PR00814BETA HEAMOGLOBIN
SIGNATURE
1558PR00814E10.174.414e−14128-144PR00814BETA HAEMOGLOBIN
SIGNATURE
1559PR00014A8.227.955e−09443-452PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1559PR00014C15.448.826e−09578-596PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1560BL00222A11.349.438e−1145-55BL00222Insulin-like growth
factor binding
proteins.
1560BL00222B11.097.300e−1765-80BL00222Insulin-like growth
factor binding
proteins.
1560BL00222C22.971.409e−29237-264BL00222Insulin-like growth
factor binding
proteins.
1560BL00484B9.041.000e−17238-251BL00484Thyroglobulin type-1
repeat proteins
proteins.
1560BL00484C17.015.737e−15262-276BL00484Thyroglobulin type-1
repeat proteins
proteins.
1561BL00222B11.097.333e−1555-70BL00222Insulin-like growth
factor binding
proteins.
1561BL00222C22.972.161e−24203-230BL00222Insulin-like growth
factor binding
proteins.
1561BL00484B9.046.143e−16204-217BL00484Thyroglobulin type-1
repeat proteins
proteins.
1561BL00484C17.011.375e−14228-242BL00484Thyroglobulin type-1
repeat proteins
proteins.
1562BL00322A9.231.000e−4030-81BL00322Histone H3 proteins.
1562BL00322B13.681.000e−40 83-135BL00322Histone H3 proteins.
1562PR00622A6.521.391e−19 3-17PR00622HISTONE H3 SIGNATURE
1562PR00622B6.921.409e−1917-31PR00622HISTONE H3 SIGNATURE
1562PR00622C8.831.391e−2834-55PR00622HISTONE H3 SIGNATURE
1562PR00622D12.711.273e−2258-75PR00622HISTONE H3 SIGNATURE
1562PR00622E15.811.281e−2180-98PR00622HISTONE H3 SIGNATURE
1562PR00622F19.511.265e−22 98-114PR00622HISTONE H3 SIGNATURE
1562PR00622G13.241.300e−28114-135PR00622HISTONE H3 SIGNATURE
1563BL00290A20.891.000e−14221-243BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1563BL00290A20.892.800e−1631-53BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1563BL00290B13.174.000e−21278-295BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1564BL00345B21.289.118e−30304-354BL00345Ets-domain proteins.
1564BL00354A3.838.875e−10244-253BL00354HMG-I and HMG-Y DNA-
binding domain proteins
(A+T-hook).
1564BL00354B3.166.468e−09241-253BL00354HMG-I and HMG-Y DNA-
binding domain proteins
(A+T-hook).
1564PR00454B20.788.380e−12299-317PR00454ETS DOMAIN SIGNATURE
1564PR00454C11.245.119e−14318-336PR00454ETS DOMAIN SIGNATURE
1564PR00454D10.895.860e−11337-355PR00454ETS DOMAIN SIGNATURE
1564PR00929A3.256.571e−09244-254PR00929AT-HOOK-LIKE DOMAIN
SIGNATURE
1564PR00929B4.385.018e−09242-253PR00929AT-HOOK-LIKE DOMAIN
SIGNATURE
1564PR00929C5.264.736e−10242-252PR00929AT-HOOK-LIKE DOMAIN
SIGNATURE
1564PR00930D5.169.407e−09233-252PR00930HIGH MOBILITY GROUP
PROTEIN (HMGY)
SIGNATURE
1565BL00290A20.897.882e−14224-246BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1565BL00290A20.899.526e−1334-56BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1565BL00290B13.176.625e−19281-298BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1565PR00818B6.951.614e−09164-180PR00818ISLET AMYLOID PROTEIN
(AMYLIN) SIGNATURE
1566BL0029928.847.943e−26 97-148BL00299Ubiquitin domain
proteins.
1568PF01105B25.122.016e−20154-205PF01105emp24/gp25L/p24 family.
1569BL00380F9.769.705e−0938-48BL00380Rhodanese proteins.
1569BL00383E10.351.692e−10256-266BL00383Tyrosine specific
protein phosphatases
proteins.
1569BL00415R7.937.655e−11302-341BL00415Synapsins proteins.
1569PR00700D12.474.462e−11253-271PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1569PR00716C17.657.750e−0926-46PR00716M-PHASE INDUCER
PHOSPHATASE SIGNATURE
1570BL00712A6.236.000e−25 2-21BL00712Ribosomal protein S17e
proteins.
1570BL00712B12.561.000e−4028-65BL00712Ribosomal protein S17e
proteins.
1570BL00712C9.671.900e−13 98-107BL00712Ribosomal protein S17e
proteins.
1571BL00388A23.143.483e−37 6-51BL00388Proteasome A-type
subunits proteins.
1571BL00388B31.382.731e−29 62-103BL00388Proteasome A-type
subunits proteins.
1571BL00388C18.792.385e−19117-138BL00388Proteasome A-type
subunits proteins.
1571BL00388D20.714.462e−24144-174BL00388Proteasome A-type
subunits proteins.
1572BL01002B7.393.118e−1414-27BL01002Translationally
controlled tumor
protein.
1572BL01002C21.976.143e−2645-75BL01002Translationally
controlled tumor
protein.
1572BL01002D18.244.706e−26109-136BL01002Translationally
controlled tumor
protein.
1573BL00298C16.401.000e−4028-71BL00298Heat shock hsp90
proteins family
proteins.
1573BL00298D17.971.000e−40 84-123BL00298Heat shock hsp90
proteins family
proteins.
1573BL00298E27.301.000e−40178-232BL00298Heat shock hsp90
proteins family
proteins.
1573BL00298F11.211.000e−40264-318BL00298Heat shock hsp90
proteins family
proteins.
1573BL00298G24.571.000e−40321-375BL00298Heat shock hsp90
proteins family
proteins.
1573BL00298H20.501.000e−40409-462BL00298Heat shock hsp90
proteins family
proteins.
1573BL00298I30.071.000e−40513-566BL00298Heat shock hsp90
proteins family
proteins.
1573BL00412D16.545.989e−10121-171BL00412Neuromodulin (GAP-43)
proteins.
1573PR00775D8.911.000e−22 9-26PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1573PR00775E8.065.500e−2834-56PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1573PR00775F12.767.188e−21 85-102PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1573PR00775G10.641.750e−23103-121PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1574BL00076A18.839.163e−1314-43BL00076Pyridine nucleotide-
disulphide
oxidoreductases class-
I.
1574BL00504A10.763.712e−1015-36BL00504Fumarate reductase/
succinate dehydrogenase
FAD-binding site
proteins.
1574BL00623A12.605.500e−1015-33BL00623GMC oxidoreductases
proteins.
1574BL00836D22.301.574e−1015-51BL00836Alanine dehydrogenase &
pyridine nucleotide
transhydrogenase.
1574BL00977A20.764.051e−0915-66BL00977FAD-dependent glycerol-
3-phosphate
dehydrogenase proteins.
1574BL00982A18.411.000e−1317-48BL00982Bacterial-type phytoene
dehydrogenase proteins.
1574BL01280A15.978.740e−0915-55BL01280Glucose inhibited
division protein A
family proteins.
1574PR00368A17.761.865e−1015-37PR00368FAD-DEPENDENT PYRIDINE
NUCLEOTIDE REDUCTASE
SIGNATURE
1574PR00368C15.743.656e−0915-40PR00368FAD-DEPENDENT PYRIDINE
NUCLEOTIDE REDUCTASE
SIGNATURE
1574PR00370A3.357.932e−1015-30PR00370FLAVIN-CONTAINING
MONOOXYGENASE (FMO)
SIGNATURE
1574PR00411A15.956.365e−1015-37PR00411PYRIDINE NUCLEOTIDE
DISULPHIDE REDUCTASE
CLASS-I SIGNATURE
1574PR00419A14.894.214e−0915-37PR00419ADRENODOXIN REDUCTASE
FAMILY SIGNATURE
1574PR00420A14.786.750e−1615-37PR00420AROMATIC-RING
HYDROXYLASE
(FLAVOPROTEIN
MONOOXYGENASE)
SIGNATURE
1574PR00469F16.516.241e−0911-35PR00469PYRIDINE NUCLEOTIDE
DISULPHIDE REDUCTASE
CLASS-II SIGNATURE
1574PR00757A6.642.324e−2215-34PR00757FLAVIN-CONTAINING AMINE
OXIDASE SIGNATURE
1574PR00757B12.542.286e−30101-123PR00757FLAVIN-CONTAINING AMINE
OXIDASE SIGNATURE
1574PR00757C13.481.600e−30183-204PR00757FLAVIN-CONTAINING AMINE
OXIDASE SIGNATURE
1574PR00757D6.413.571e−29206-228PR00757FLAVIN-CONTAINING AMINE
OXIDASE SIGNATURE
1574PR00757E11.481.000e−27303-322PR00757FLAVIN-CONTAINING AMINE
OXIDASE SIGNATURE
1574PR00757F15.601.129e−28389-408PR00757FLAVIN-CONTAINING AMINE
OXIDASE SIGNATURE
1574PR00757G4.345.345e−30410-432PR00757FLAVIN-CONTAINING AMINE
OXIDASE SIGNATURE
1574PR00757H9.221.096e−23441-458PR00757FLAVIN-CONTAINING AMINE
OXIDASE SIGNATURE
1574PR00757I12.663.368e−29471-493PR00757FLAVIN-CONTAINING AMINE
OXIDASE SIGNATURE
1575BL00290A20.892.421e−13224-246BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1575BL00290A20.894.600e−1634-56BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1575BL00290B13.174.000e−21281-298BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1576BL00290A20.896.684e−13129-151BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1576BL00290B13.179.308e−15186-203BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1577BL0046922.221.000e−40 78-132BL00469Nucleoside diphosphate
kinases proteins.
1578BL00113A12.744.600e−09142-158BL00113Adenylate kinase
proteins.
1578BL00291A4.498.448e−0947-81BL00291Prion protein.
1578BL00674B4.468.909e−11138-159BL00674AAA-protein family
proteins.
1578PR00300A9.565.442e−09141-159PR00300ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT SIGNATURE
1578PR00449A13.201.692e−10139-160PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1578PR00449D10.796.400e−15241-254PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1578PR00449E13.501.529e−11276-298PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1578PR00830A8.418.644e−09145-164PR00830ENDOPEPTIDASE LA (LON)
SERINE PROTEASE (S16)
SIGNATURE
1579BL01257A11.151.000e−40 2-44BL01257Ribosomal protein L10e
proteins.
1579BL01257B12.561.000e−40 62-101BL01257Ribosomal protein L10e
proteins.
1579BL01257C11.431.000e−40102-136BL01257Ribosomal protein L10e
proteins.
1579BL01257D18.801.000e−40137-176BL01257Ribosomal protein L10e
proteins.
1579PF00774D10.599.250e−10189-214PF00774Dihydropyridine
sensitive L-type
calcium channel (Beta
subuni.
1580BL01204A17.741.000e−4019-66BL01204NF-kappa-B/Rel/dorsal
domain proteins.
1580BL01204B15.414.000e−16113-126BL01204NF-kappa-B/Rel/dorsal
domain proteins.
1580BL01204C13.939.727e−18150-168BL01204NF-kappa-B/Rel/dorsal
domain proteins.
1580BL01204D16.421.000e−40185-228BL01204NF-kappa-B/Rel/dorsal
domain proteins.
1580BL01204E13.838.875e−31233-257BL01204NF-kappa-B/Rel/dorsal
domain proteins.
1580PR00057A10.141.450e−2425-42PR00057TRANSCRIPTION FACTOR
NF-KB SIGNATURE
1580PR00057B11.815.629e−15175-189PR00057TRANSCRIPTION FACTOR
NF-KB SIGNATURE
1580PR00057C7.434.462e−25208-228PR00057TRANSCRIPTION FACTOR
NF-KB SIGNATURE
1580PR00057D11.941.563e−24239-257PR00057TRANSCRIPTION FACTOR
NF-KB SIGNATURE
1580PR00057E15.744.000e−14280-294PR00057TRANSCRIPTION FACTOR
NF-KB SIGNATURE
1581BL00284A15.647.231e−1754-77BL00284Serpins proteins.
1581BL00284B17.991.783e−15155-175BL00284Serpins proteins.
1581BL00284C28.564.913e−31184-225BL00284Serpins proteins.
1581BL00284D16.346.538e−18296-322BL00284Serpins proteins.
1581BL00284E19.158.875e−23378-402BL00284Serpins proteins.
1582BL01251A17.374.240e−31 1-36BL01251Proliferating cell
nuclear antigen
proteins.
1582BL01251B17.251.000e−4037-82BL01251Proliferating cell
nuclear antigen
proteins.
1582BL01251C19.351.000e−40108-157BL01251Proliferating cell
nuclear antigen
proteins.
1582BL01251D23.721.000e−40197-250BL01251Proliferating cell
nuclear antigen
proteins.
1582PR00339A5.836.400e−2110-29PR00339PROLIFERATING CELL
NUCLEAR ANTIGEN
(CYCLIN) SIGNATURE
1582PR00339B9.943.250e−2034-52PR00339PROLIFERATING CELL
NUCLEAR ANTIGEN
(CYCLIN) SIGNATURE
1582PR00339C13.917.158e−2956-80PR00339PROLIFERATING CELL
NUCLEAR ANTIGEN
(CYCLIN) SIGNATURE
1582PR00339D12.908.650e−26110-132PR00339PROLIFERATING CELL
NUCLEAR ANTIGEN
(CYCLIN) SIGNATURE
1582PR00339E14.052.000e−18203-217PR00339PROLIFERATING CELL
NUCLEAR ANTIGEN
(CYCLIN) SIGNATURE
1582PR00339F10.561.000e−22241-258PR00339PROLIFERATING CELL
NUCLEAR ANTIGEN
(CYCLIN) SIGNATURE
1583BL00507A8.794.643e−09309-329BL00507Nickel-dependent
hydrogenases large
subunit proteins.
1583PD02870A14.101.563e−1739-55PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1583PD02870B18.837.968e−34 93-125PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1583PD02870C24.419.419e−31136-170PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1583PD02870D15.744.000e−33192-226PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1583PD02870E12.751.545e−16244-260PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1583PD02870F22.824.536e−22301-325PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1584BL01024A10.261.000e−4026-72BL01024Protein phosphatase 2A
regulatory subunit PR55
proteins.
1584BL01024B8.911.000e−40 90-130BL01024Protein phosphatase 2A
regulatory subunit PR55
proteins.
1584BL01024C7.801.000e−40150-188BL01024Protein phosphatase 2A
regulatory subunit PR55
proteins.
1584BL01024D13.221.000e−40189-225BL01024Protein phosphatase 2A
regulatory subunit PR55
proteins.
1584BL01024E11.961.000e−40226-269BL01024Protein phosphatase 2A
regulatory subunit PR55
proteins.
1584BL01024F9.421.000e−40270-320BL01024Protein phosphatase 2A
regulatory subunit PR55
proteins.
1584BL01024G11.091.000e−40321-352BL01024Protein phosphatase 2A
regulatory subunit PR55
proteins.
1584BL01024H13.881.000e−40393-445BL01024Protein phosphatase 2A
regulatory subunit PR55
proteins.
1584PR00600A11.616.000e−2635-55PR00600PROTEIN PHOSPHATASE
PP2A 55 kd REGULATORY
SUBUNIT SIGNATURE
1584PR00600B11.271.500e−3770-98PR00600PROTEIN PHOSPHATASE
PP2A 55 kd REGULATORY
SUBUNIT SIGNATURE
1584PR00600C10.703.842e−35 99-127PR00600PROTEIN PHOSPHATASE
PP2A 55 kd REGULATORY
SUBUNIT SIGNATURE
1584PR00500D10.704.667e−36176-203PR00600PROTEIN PHOSPHATASE
PP2A 55 kd REGULATORY
SUBUNIT SIGNATURE
1584PR00600E12.871.000e−34204-231PR00600PROTEIN PHOSPHATASE
PP2A 55 kd REGULATORY
SUBUNIT SIGNATURE
1584PR00600F18.739.625e−36232-260PR00600PROTEIN PHOSPHATASE
PP2A 55 kd REGULATORY
SUBUNIT SIGNATURE
1584PR00600G8.776.143e−35261-288PR00600PROTEIN PHOSPHATASE
PP2A 55 kd REGULATORY
SUBUNIT SIGNATURE
1584PR00600H8.995.500e−36289-316PR00600PROTEIN PHOSPHATASE
PP2A 55 kd REGULATORY
SUBUNIT SIGNATURE
1584PR00600I10.136.625e−34317-342PR00600PROTEIN PHOSPHATASE
PP2A 55 kd REGULATORY
SUBUNIT SIGNATURE
1584PR00600J12.567.000e−37343-369PR00600PROTEIN PHOSPHATASE
PP2A 55 kd REGULATORY
SUBUNIT SIGNATURE
1584PR00600K11.123.647e−37413-442PR00600PROTEIN PHOSPHATASE
PP2A 55 kd REGULATORY
SUBUNIT SIGNATURE
1585DM00372A19.181.000e−4019-63DM00372CARCINOEMBRYONIC
ANTIGEN PRECURSOR
AMINO-TERMINAL DOMAIN.
1585DM00372B20.319.763e−35 82-126DM00372CARCINOEMBRYONIC
ANTIGEN PRECURSOR
AMINO-TERMINAL DOMAIN.
1585DM00372C23.696.921e−23321-356DM00372CARCINOEMBRYONIC
ANTIGEN PRECURSOR
AMINO-TERMINAL DOMAIN.
1586BL00214A21.171.257e−18 5-30BL00214Cytosolic fatty-acid
binding proteins.
1586BL00214B26.516.516e−2646-90BL00214Cytosolic fatty-acid
binding proteins.
1586PR00178A15.075.846e−17 6-26PR00178FATTY ACID-BINDING
PROTEIN SIGNATURE
1586PR00178B10.525.800e−1040-51PR00178FATTY ACID-BINDING
PROTEIN SIGNATURE
1586PR00178C20.543.919e−1966-93PR00178FATTY ACID-BINDING
PROTEIN SIGNATURE
1586PR00178D13.523.132e−14112-130PR00178FATTY ACID-BINDING
PROTEIN SIGNATURE
1587BL00107A18.393.842e−18768-798BL00107Protein kinases ATP-
binding region
proteins.
1587BL00107B13.319.100e−14835-850BL00107Protein kinases ATP-
binding region
proteins.
1587BL00239B25.152.849e−14634-681BL00239Receptor tyrosine
kinase class II
proteins.
1587BL00239C18.753.684e−13755-777BL00239Receptor tyrosine
kinase class II
proteins.
1587BL00239D16.814.356e−11780-805BL00239Receptor tyrosine
kinase class II
proteins.
1587BL00239E17.146.891e−32807-856BL00239Receptor tyrosine
kinase class II
proteins.
1587BL00239F28.151.632e−19862-906BL00239Receptor tyrosine
kinase class II
proteins.
1587BL00240A22.726.516e−2021-49BL00240Receptor tyrosine
kinase class III
proteins.
1587BL00240B24.709.500e−20417-440BL00240Receptor tyrosine
kinase class III
proteins.
1587BL00240C22.581.000e−40574-622BL00240Receptor tyrosine
kinase class III
proteins.
1587BL00240D23.071.000e−40623-677BL00240Receptor tyrosine
kinase class III
proteins.
1587BL00240E11.561.000e−40754-791BL00240Receptor tyrosine
kinase class III
proteins.
1587BL00240F17.741.000e−40806-853BL00240Receptor tyrosine
kinase class III
proteins.
1587BL00240G28.451.000e−40854-906BL00240Receptor tyrosine
kinase class III
proteins.
1587BL00790M8.745.747e−09759-780BL00790Receptor tyrosine
kinase class V
proteins.
1587BL00790N13.251.098e-11781-807BL00790Receptor tyrosine
kinase class V
proteins.
1587BL00790O7.683.302e-15814-846BL00790Receptor tyrosine
kinase class V
proteins.
1587BL00790Q15.613.536e-10873-921BL00790Receptor tyrosine
kinase class V
proteins.
1587BL50001B17.404.130e-10765-785BL50001Src homology 2 (SH2)
domain proteins
profile.
1587BL50001D11.004.750e−09835-845BL50001Src homology 2 (SH2)
domain proteins
profile.
1587PR00109A15.008.615e−15663-676PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1587PR00109B12.275.500e−18768-786PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1587PR00109C12.852.500e−14817-827PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1587PR00109D17.047.158e−23836-858PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1587PR00109E14.411.321e−16881-903PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1590BL00442B14.985.765e−09237-248BL00442Glutamine
amidotransferases
class-I proteins.
1591BL00962A11.871.600e−1013-25BL00962Ribosomal protein S2
proteins.
1591BL00962B36.154.600e−3628-81BL00962Ribosomal protein S2
proteins.
1591BL00962C15.909.591e−17 94-111BL00962Ribosomal protein S2
proteins.
1591BL00962D22.515.500e−35119-162BL00962Ribosomal protein S2
proteins.
1591PR00395A16.936.464e−1515-33PR00395RIBOSOMAL PROTEIN S2
SIGNATURE
1591PR00395B10.551.771e−1045-54PR00395RIBOSOMAL PROTEIN S2
SIGNATURE
1591PR00395C16.171.000e−17 94-111PR00395RIBOSOMAL PROTEIN S2
SIGNATURE
1591PR00395D13.047.000e−17119-136PR00395RIBOSOMAL PROTEIN S2
SIGNATURE
1591PR00395E14.464.103e−11136-147PR00395RIBOSOMAL PROTEIN S2
SIGNATURE
1591PR00395F10.566.400e−16157-171PR00395RIBOSOMAL PROTEIN S2
SIGNATURE
1592BL00740B19.763.813e−09690-710BL00740MAM domain proteins.
1592PR00597A12.961.000e−25375-396PR00597GELSOLIN FAMILY
SIGNATURE
1592PR00597A12.964.575e−09742-763PR00597GELSOLIN FAMILY
SIGNATURE
1592PR00597B9.785.629e−09 85-101PR00597GELSOLIN FAMILY
SIGNATURE
1592PR00597B9.787.000e−20464-480PR00597GELSOLIN FAMILY
SIGNATURE
1592PR00597C14.199.000e−23489-507PR00597GELSOLIN FAMILY
SIGNATURE
1592PR00597D12.774.522e−24522-542PR00597GELSOLIN FAMILY
SIGNATURE
1592PR00597D12.777.723e−09144-164PR00597GELSOLIN FAMILY
SIGNATURE
1592PR00597E13.464.130e−21576-596PR00597GELSOLIN FAMILY
SIGNATURE
1592PR00597F16.294.522e−21634-653PR00597GELSOLIN FAMILY
SIGNATURE
1592PR00597G8.551.429e−28690-712PR00597GELSOLIN FAMILY
SIGNATURE
1592PR00597H15.325.500e−22719-738PR00597GELSOLIN FAMILY
SIGNATURE
1595BL01019A13.203.629e−0946-85BL01019ADP-ribosylation
factors family
proteins.
1595BL01115A10.222.688e−1412-55BL01115GTP-binding nuclear
protein ran proteins.
1595PR00449A13.207.000e−2012-33PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1595PR00449B14.347.500e−1235-51PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1595PR00449C17.275.500e−2453-75PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1595PR00449D10.795.500e−14115-128PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1595PR00449E13.505.263e−17150-172PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1596BL00578A14.242.800e−37 1-31BL00578Ribosomal protein S6e
proteins.
1596BL00578B15.151.000e−4039-89BL00578Ribosomal protein S6e
proteins.
1596BL00578C9.531.000e−40120-157BL00578Ribosomal protein S6e
proteins.
1596BL00578D16.681.000e−40164-213BL00578Ribosomal protein S6e
proteins.
1597BL00472B14.678.448e−1231-48BL00472Small cytokines
(intercrine/chemokine)
C-C subfamily signatur.
1597PR00436D12.231.106e−1072-95PR00436INTERLEUKIN-8 SIGNATURE
1598DM00895E15.723.333e−11527-551DM008957 kw REVERSE
TRANSCRIPTASE RNA
POLYMERASE.
1598DM01354A11.774.462e−2913-40DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354B14.719.280e−3341-68DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354C8.795.680e−2169-86DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354D10.594.960e−32 87-114DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354E18.693.025e−28115-144DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354F14.567.943e−37145-180DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354G11.579.500e−37181-211DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354H18.008.071e−30212-251DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354I15.552.800e−39252-292DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354J15.128.541e−31293-324DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354K9.351.200e−30325-356DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354L11.734.000e−30357-383DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354M12.504.960e−33384-413DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354N13.171.000e−40414-458DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354O8.731.000e−40465-510DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354P9.183.308e−40511-544DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354Q9.231.000e−40545-599DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354R8.505.714e−31600-629DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354S11.617.300e−26630-650DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354T9.481.000e−40651-693DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354U12.247.171e−21740-759DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354V12.971.000e−40760-806DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354W12.646.760e−23807-826DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354X13.861.000e−40827-865DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354Y10.691.000e−40876-915DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1598DM01354Z9.061.000e−401190-1238DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1600BL00322A9.231.000e−4032-83BL00322Histone H3 proteins.
1600BL00322B13.681.000e−40 85-137BL00322Histone H3 proteins.
1600PR00622A6.521.391e−19 5-19PR00622HISTONE H3 SIGNATURE
1600PR00622B6.921.409e−1919-33PR00622HISTONE H3 SIGNATURE
1600PR00622C8.831.391e−2836-57PR00622HISTONE H3 SIGNATURE
1600PR00622D12.711.273e−2260-77PR00622HISTONE H3 SIGNATURE
1600PR00622E15.811.281e−21 82-100PR00622HISTONE H3 SIGNATURE
1600PR00622F19.511.265e−22100-116PR00622HISTONE H3 SIGNATURE
1600PR00622G13.241.300e−28116-137PR00622HISTONE H3 SIGNATURE
1601BL00065A31.924.682e−27115-156BL00065D-isomer specific 2-
hydroxyacid
dehydrogenases NAD-
binding si.
1601BL00065B16.977.652e−19179-203BL00065D-isomer specific 2-
hydroxyacid
dehydrogenases NAD-
binding si.
1601BL00065C27.256.000e−37253-303BL00065D-isomer specific 2-
hydroxyacid
dehydrogenases NAD-
binding si.
1601BL00071A5.818.258e−09184-195BL00071Glyceraldehyde 3-
phosphate dehydrogenase
proteins.
1603BL00388A23.145.500e−39 8-53BL00388Proteasome A-type
subunits proteins.
1603BL00388B31.387.207e−27 66-107BL00388Proteasome A-type
subunits proteins.
1603BL00388C18.794.706e−16121-142BL00388Proteasome A-type
subunits proteins.
1603BL00388D20.716.897e−23149-1798L00388Proteasome A-type
subunits proteins.
1603PF0022714.686.294e−1015-26PF00227Proteasome A-type and
B-type.
1604BL00053A8.835.320e−12 5-17BL00053Ribosomal protein S8
proteins.
1604BL00053B14.564.789e−1458-75BL00053Ribosomal protein S8
proteins.
1604BL00053C16.715.500e−26 98-130BL00053Ribosomal protein S8
proteins.
1607BL01170A12.349.143e−40139-174BL01170Ribosomal protein L6e
proteins.
1607BL01170B19.545.821e−37251-288BL01170Ribosomal protein L6e
proteins.
1607PD01457A16.519.845e−09 67-111PD01457RIBOSOMAL PROTEIN 40S
ZINC-FINGER METAL.
1608BL50040A12.981.450e−14 4-15BL50040Elongation factor 1
gamma chain profile.
1608BL50040B13.657.000e−3053-78BL50040Elongation factor 1
gamma chain profile.
1608BL50040C22.623.739e−38135-177BL50040Elongation factor 1
gamma chain profile.
1608BL50040D17.411.000e−40273-322BL50040Elongation factor 1
gamma chain profile.
1608BL50040E18.791.000e−40327-381BL50040Elongation factor 1
gamma chain profile.
1608BL50040F18.995.320e−40384-421BL50040Elongation factor 1
gamma chain profile.
1608BL50040G8.151.900e−13427-437BL50040Elongation factor 1
gamma chain profile.
1608DM01181C17.276.055e−12125-162DM011817 kw 103-1A
LACTOYLGLUTATHIONE
GLUTATHIONE LYASE.
1608PF0004321.839.735e−1157-86PF00043Glutathione S-
transferases.
1609BL01052A16.122.875e−35 3-34BL01052Calponin family repeat
proteins.
1609BL01052B15.315.219e−2652-77BL01052Calponin family repeat
proteins.
1609BL01052C18.511.000e−40 88-127BL01052Calponin family repeat
proteins.
1609BL01052D10.264.462e−24175-194BL01052Calponin family repeat
proteins.
1609PR00888A11.877.750e−18 3-17PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
1609PR00888B13.721.321e−1422-35PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
1609PR00888C12.272.286e−1752-67PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
1609PR00888D16.099.550e−19 89-105PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
1609PR00888E11.812.800e−18105-120PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
1609PR00888F7.444.600e−18126-140PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
1609PR00888G12.739.438e−15163-176PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
1609PR00888H9.978.269e−20176-191PR00888SMOOTH MUSCLE
PROTEIN/CALPONIN FAMILY
SIGNATURE
1609PR00889E12.187.300e−11172-187PR00889CALPONIN SIGNATURE
1609PR00890A8.611.000e−2634-53PR00890SMOOTH MUSCLE PROTEIN
22-ALPHA (TRANSGELIN)
SIGNATURE
1609PR00890B8.756.318e−1962-77PR00890SMOOTH MUSCLE PROTEIN
22-ALPHA (TRANSGELIN)
SIGNATURE
1609PR00890C8.221.600e−1985-98PR00890SMOOTH MUSCLE PROTEIN
22-ALPHA (TRANSGELIN)
SIGNATURE
1609PR00890D16.171.130e−13119-128PR00890SMOOTH MUSCLE PROTEIN
22-ALPHA (TRANSGELIN)
SIGNATURE
1609PR00890E14.341.429e−27136-155PR00890SMOOTH MUSCLE PROTEIN
22-ALPHA (TRANSGELIN)
SIGNATURE
1609PR00890F12.921.643e−17162-174PR00890SMOOTH MUSCLE PROTEIN
22-ALPHA (TRANSGELIN)
SIGNATURE
1612PR00194A7.867.652e−09180-197PR00194TROPOMYOSIN SIGNATURE
1614DM00934A20.078.663e−11 7-54DM00934kw DIHYDROFLAVONOL
YOL151W YDR541C
YGL157W.
1616BL0060527.671.000e−40 74-127BL00605ATP synthase c subunit
proteins.
1616PR00124A8.812.125e−1770-89PR00124ATP SYNTHASE C SUBUNIT
SIGNATURE
1616PR00124A8.818.603e−0972-91PR00124ATP SYNTHASE C SUBUNIT
SIGNATURE
1616PR00124B14.661.000e−15 91-106PR00124ATP SYNTHASE C SUBUNIT
SIGNATURE
1616PR00124C12.423.250e−27108-133PR00124ATP SYNTHASE C SUBUNIT
SIGNATURE
1618BL00310E19.928.875e−12257-281BL00310Lysosome-associated
membrane glycoproteins
duplicated domain
proteins.
1618BL00310F23.263.377e−10291-345BL00310Lysosome-associated
membrane glycoproteins
duplicated domain
proteins.
1618PR00336A12.866.455e−24158-182PR00336LYSOSOME-ASSOCIATED
MEMBRANE GLYCOPROTEIN
SIGNATURE
1618PR00336B15.429.027e−13269-283PR00336LYSOSOME-ASSOCIATED
MEMBRANE GLYCOPROTEIN
SIGNATURE
1618PR00336C14.479.438e−11306-318PR00336LYSOSOME-ASSOCIATED
MEMBRANE GLYCOPROTEIN
SIGNATURE
1618PR00336D9.965.705e−19319-341PR00336LYSOSOME-ASSOCIATED
MEMBRANE GLYCOPROTEIN
SIGNATURE
1618PR00336E11.591.711e−12341-353PR00336LYSOSOME-ASSOCIATED
MEMBRANE GLYCOPROTEIN
SIGNATURE
1619BL0028024.615.091e−38317-360BL00280Pancreatic trypsin
inhibitor (Kunitz)
family proteins.
1619BL00319A17.621.000e−40 77-125BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1619BL00319B17.022.440e−29173-198BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1619BL00319C17.126.143e−30265-298BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1619BL00319D21.291.000e−40365-414BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1619BL00319E12.661.000e−40438-479BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1619BL00319F13.951.000e−40480-522BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1619BL00319G16.931.000e−40717-762BL00319Amyloidogenic
glycoprotein
extracellular domain
proteins.
1619PR00203A13.983.829e−21193-211PR00203AMYLOID A4 PROTEIN
PRECURSOR SIGNATURE
1619PR00203B11.388.500e−28381-404PR00203AMYLOID A4 PROTEIN
PRECURSOR SIGNATURE
1619PR00203C6.374.667e−27692-717PR00203AMYLOID A4 PROTEIN
PRECURSOR SIGNATURE
1619PR00203D13.572.895e−30738-760PR00203AMYLOID A4 PROTEIN
PRECURSOR SIGNATURE
1619PR00759A14.512.440e−10307-321PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1619PR00759B11.267.000e−13335-345PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1619PR00759C14.151.000e−14345-360PR00759BASIC PROTEASE (KUNITZ-
TYPE) INHIBITOR FAMILY
SIGNATURE
1620BL0063434.381.333e−37 93-143BL00634Ribosomal protein L30
proteins.
1622BL00107A18.399.400e−221012-1042BL00107Protein kinases ATP-
binding region
proteins.
1622BL00107B13.317.300e−141079-1094BL00107Protein kinases ATP-
binding region
proteins.
1622BL00239C18.751.913e−10999-1021BL00239Receptor tyrosine
kinase class II
proteins.
1622BL00239D16.819.043e−141024-1049BL00239Receptor tyrosine
kinase class II
proteins.
1622BL00239E17.144.436e−321051-1100BL00239Receptor tyrosine
kinase class II
proteins.
1622BL00239F28.152.770e−171106-1150BL00239Receptor tyrosine
kinase class II
proteins.
1622BL00240A22.727.500e−1832-60BL00240Receptor tyrosine
kinase class III
proteins.
1622BL00240B24.705.333e−15575-598BL00240Receptor tyrosine
kinase class III
proteins.
1622BL00240B24.705.404e−09452-475BL00240Receptor tyrosine
kinase class III
proteins.
1622BL00240B24.706.651e−10680-703BL00240Receptor tyrosine
kinase class III
proteins.
1622BL00240C22.581.000e−40819-867BL00240Receptor tyrosine
kinase class III
proteins.
1622BL00240D23.071.000e−40868-922BL00240Receptor tyrosine
kinase class III
proteins.
1622BL00240E11.563.182e−40 998-1035BL00240Receptor tyrosine
kinase class III
proteins.
1622BL00240F17.741.000e−401050-1097BL00240Receptor tyrosine
kinase class III
proteins.
1622BL00240G28.451.000e−401098-1150BL00240Receptor tyrosine
kinase class III
proteins.
1622BL00790M8.741.692e−091003-1024BL00790Receptor tyrosine
kinase class V
proteins.
1622BL00790N13.256.929e−131025-1051BL00790Receptor tyrosine
kinase class V
proteins.
1622BL00790O7.684.539e−141058-1090BL00790Receptor tyrosine
kinase class V
proteins.
1622BL00790Q15.618.533e−151117-1165BL00790Receptor tyrosine
kinase class V
proteins.
1622BL50001B17.401.000e−121009-1029BL50001Src homology 2 (SH2)
domain proteins
profile.
1622BL50001D11.009.100e−101079-1089BL50001Src homology 2 (SH2)
domain proteins
profile.
1622DM0017913.978.826e−09304-313DM00179w KINASE ALPHA ADHESION
T-CELL.
1622PD02870B18.839.521e−09621-653PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1622PD02870B18.839.617e−09716-748PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1622PD02870D15.741.200e−10621-655PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1622PD02870D15.745.117e−09390-424PD02870RECEPTOR INTERLEUKIN-1
PRECURSOR.
1622PR00109A15.004.808e−11909-922PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1622PR00109B12.275.714e−191012-1030PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1622PR00109C12.853.118e−121061-1071PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1622PR00109D17.042.286e−251080-1102PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1622PR00109E14.417.857e−191125-1147PR00109TYROSINE KINASE
CATALYTIC DOMAIN
SIGNATURE
1622PR00573D15.571.000e−091284-1299PR00573INTERLEUKIN 8B RECEPTOR
SIGNATURE
1623DM01354Z9.065.747e−14 1-49DM01354kw TRANSCRIPTASE
REVERSE II ORF2.
1624BL00262A12.488.200e−09523-540BL00262Insulin family
proteins.
1624BL01282B30.495.243e−09517-555BL01282BIR repeat proteins.
1625BL00779A14.014.667e−2731-57BL00779Glycoprotein hormones
alpha chain proteins.
1625BL00779B6.451.429e−2058-73BL00779Glycoprotein hormones
alpha chain proteins.
1625BL00779C14.391.333e−37 82-115BL00779Glycoprotein hormones
alpha chain proteins.
1625PR00274A9.962.500e−1530-44PR00274GLYCOPROTEIN HORMONE
ALPHA CHAIN SIGNATURE
1625PR00274B9.158.091e−2650-69PR00274GLYCOPROTEIN HORMONE
ALPHA CHAIN SIGNATURE
1625PR00274C13.495.959e−2270-87PR00274GLYCOPROTEIN HORMONE
ALPHA CHAIN SIGNATURE
1625PR00274D9.711.900e−23 99-115PR00274GLYCOPROTEIN HORMONE
ALPHA CHAIN SIGNATURE
1626BL01019A13.207.353e−10203-242BL01019ADP-ribosylation
factors family
proteins.
1626PR00318A7.844.000e−1842-57PR00318ALPHA G-PROTEIN
(TRANSDUCIN) SIGNATURE
1626PR00318B14.794.429e−22190-212PR00318ALPHA G-PROTEIN
(TRANSDUCIN) SIGNATURE
1626PR00318C12.099.526e−22219-236PR00318ALPHA G-PROTEIN
(TRANSDUCIN) SIGNATURE
1626PR00318D16.283.625e−26241-269PR00318ALPHA G-PROTEIN
(TRANSDUCIN) SIGNATURE
1626PR00318E7.232.875e−11287-296PR00318ALPHA G-PROTEIN
(TRANSDUCIN) SIGNATURE
1626PR00440A9.189.416e−1442-57PR00440G-PROTEIN ALPHA SUBUNIT
GROUP 12 SIGNATURE
1626PR00440B13.277.078e−13190-212PR00440G-PROTEIN ALPHA SUBUNIT
GROUP 12 SIGNATURE
1626PR00440C9.547.197e−15219-236PR00440G-PROTEIN ALPHA SUBUNIT
GROUP 12 SIGNATURE
1626PR00440D8.155.081e−16241-269PR00440G-PROTEIN ALPHA SUBUNIT
GROUP 12 SIGNATURE
1626PR00440E11.163.160e−10288-296PR00440G-PROTEIN ALPHA SUBUNIT
GROUP 12 SIGNATURE
1626PR00441A10.695.725e−1742-57PR00441G-PROTEIN ALPHA SUBUNIT
GROUP I SIGNATURE
1626PR00441B16.167.709e−18190-212PR00441G-PROTEIN ALPHA SUBUNIT
GROUP I SIGNATURE
1626PR00441C14.175.245e−16219-236PR00441G-PROTEIN ALPHA SUBUNIT
GROUP I SIGNATURE
1626PR00441D14.449.847e−20241-269PR00441G-PROTEIN ALPHA SUBUNIT
GROUP I SIGNATURE
1626PR00441E8.358.377e−10288-296PR00441G-PROTEIN ALPHA SUBUNIT
GROUP I SIGNATURE
1626PR00442A6.466.865e−1342-57PR00442G-PROTEIN ALPHA SUBUNIT
GROUP Q SIGNATURE
1626PR00442B7.175.390e−13190-213PR00442G-PROTEIN ALPHA SUBUNIT
GROUP Q SIGNATURE
1626PR00442C17.615.985e−16219-236PR00442G-PROTEIN ALPHA SUBUNIT
GROUP Q SIGNATURE
1626PR00442D9.299.679e−13241-269PR00442G-PROTEIN ALPHA SUBUNIT
GROUP Q SIGNATURE
1626PR00442E7.231.273e−10288-296PR00442G-PROTEIN ALPHA SUBUNIT
GROUP Q SIGNATURE
1626PR00443A15.161.097e−1942-57PR00443G-PROTEIN ALPHA SUBUNIT
GROUP S SIGNATURE
1626PR00443B9.253.000e−29 94-117PR00443G-PROTEIN ALPHA SUBUNIT
GROUP S SIGNATURE
1626PR00443C14.351.346e−29190-212PR00443G-PROTEIN ALPHA SUBUNIT
GROUP S SIGNATURE
1626PR00443D13.151.205e−25219-236PR00443G-PROTEIN ALPHA SUBUNIT
GROUP S SIGNATURE
1626PR00443E11.982.421e−36241-269PR00443G-PROTEIN ALPHA SUBUNIT
GROUP S SIGNATURE
1626PR00443F12.681.092e−11288-296PR00443G-PROTEIN ALPHA SUBUNIT
GROUP S SIGNATURE
1626PR00443G7.191.750e−29334-356PR00443G-PROTEIN ALPHA SUBUNIT
GROUP S SIGNATURE
1627BL00030A14.391.000e−1216-34BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
1627BL00030A14.391.500e−10107-125BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
1627BL00030B7.031.900e−11146-155BL00030Eukaryotic RNA-binding
region RNP-1 proteins.
1628BL00353C14.834.814e−09 1-47BL00353HMG1/2 proteins.
1628PR00901L11.745.348e−0977-90PR00901PHEROMONE B ALPHA-1
RECEPTOR SIGNATURE
1629BL0108220.377.750e−40152-191BL01082Ribosomal protein L7Ae
proteins.
1629PR00881A9.947.517e−13136-150PR00881RIBOSOMAL PROTEIN
L7A/RS6 FAMILY
SIGNATURE
1629PR00881B9.014.000e−17155-168PR00881RIBOSOMAL PROTEIN
L7A/RS6 FAMILY
SIGNATURE
1629PR00881C12.761.000e−13171-181PR00881RIBOSOMAL PROTEIN
L7A/RS6 FAMILY
SIGNATURE
1629PR00881D11.608.500e−16181-195PR00881RIBOSOMAL PROTEIN
L7A/RS6 FAMILY
SIGNATURE
1629PR00882A8.803.160e−2236-53PR00882RIBOSOMAL PROTEIN L7A
FAMILY SIGNATURE
1629PR00882B9.471.000e−2253-70PR00882RIBOSOMAL PROTEIN L7A
FAMILY SIGNATURE
1629PR00882C15.182.969e−2373-92PR00882RIBOSOMAL PROTEIN L7A
FAMILY SIGNATURE
1629PR00882D14.856.500e−17 97-110PR00882RIBOSOMAL PROTEIN L7A
FAMILY SIGNATURE
1629PR00882E14.992.216e−21132-152PR00882RIBOSOMAL PROTEIN L7A
FAMILY SIGNATURE
1629PR00882F13.814.273e−26193-217PR00882RIBOSOMAL PROTEIN L7A
FAMILY SIGNATURE
1629PR00882G10.278.500e−25225-245PR00882RIBOSOMAL PROTEIN L7A
FAMILY SIGNATURE
1629PR00884C7.057.409e−10154-165PR00884RIBOSOMAL PROTEIN HS6
SIGNATURE
1630BL00529A22.061.000e−40 5-49BL00529Ribosomal protein S24e
proteins.
1630BL00529B20.081.000e−4055-99BL00529Ribosomal protein S24e
proteins.
1631BL00612A12.097.171e−09 3-18BL00612Osteonectin domain
proteins.
1631PD0146920.591.346e−29357-388PD01469GLYCOPROTEIN PROTEIN
PRECURSOR SA.
1631PD0146920.597.176e−19451-482PD01469GLYCOPROTEIN PROTEIN
PRECURSOR SA.
1632BL00326A14.016.651e−09162-195BL00326Tropomyosins proteins.
1632BL00326A14.019.308e−37 1-34BL00326Tropomyosins proteins.
1632BL00326B7.681.000e−40 81-129BL00326Tropomyosins proteins.
1632BL00326B7.683.838e−1039-87BL00326Tropomyosins proteins.
1632BL00326C9.991.000e−40137-190BL00326Tropomyosins proteins.
1632BL00326C9.992.116e−09 95-148BL00326Tropomyosins proteins.
1632BL00326C9.993.306e−09193-246BL00326Tropomyosins proteins.
1632BL00326D8.761.000e−40220-260BL00326Tropomyosins proteins.
1632BL00326D8.767.511e−1259-99BL00326Tropomyosins proteins.
1632PR00194A7.864.857e−21 84-101PR00194TROPOMYOSIN SIGNATURE
1632PR00194B10.246.143e−26120-140PR00194TROPOMYOSIN SIGNATURE
1632PR00194C6.381.450e−32145-173PR00194TROPOMYOSIN SIGNATURE
1632PR00194D9.571.788e−0921-44PR00194TROPOMYOSIN SIGNATURE
1632PR00194D9.576.400e−23175-198PR00194TROPOMYOSIN SIGNATURE
1632PR00194E8.741.000e−30231-256PR00194TROPOMYOSIN SIGNATURE
1633BL00266A15.695.200e−2646-72BL00266Somatotropin, prolactin
and related hormones
proteins.
1633BL00266B24.481.857e−29 86-123BL00266Somatotropin, prolactin
and related hormones
proteins.
1633BL00266C13.665.304e−12146-162BL00266Somatotropin, prolactin
and related hormones
proteins
1633BL00266D12.721.818e−27197-220BL00266Somatotropin, prolactin
and related hormones
proteins.
1633PR00836A14.409.471e−1486-99PR00836SOMATOTROPIN HORMONE
FAMILY SIGNATURE
1633PR00836B16.593.571e−15108-126PR00836SOMATOTROPIN HORMONE
FAMILY SIGNATURE
1633PR00836C11.952.500e−17190-206PR00836SOMATOTROPIN HORMONE
FAMILY SIGNATURE
1633PR00836D13.052.688e−17206-220PR00836SOMATOTROPIN HORMONE
FAMILY SIGNATURE
1635BL00383A13.346.000e−091657-1671BL00383Tyrosine specific
protein phosphatases
proteins.
1635BL00383A13.349.550e−141368-1382BL00383Tyrosine specific
protein phosphatases
proteins.
1635BL00383B7.616.143e−121393-1401BL00383Tyrosine specific
protein phosphatases
proteins.
1635BL00383B7.618.500e−091682-1690BL00383Tyrosine specific
protein phosphatases
proteins.
1635BL00383C10.101.000e−101712-1722BL00383Tyrosine specific
protein phosphatases
proteins.
1635BL00383C10.104.500e−131423-1433BL00383Tyrosine specific
protein phosphatases
proteins.
1635BL00383D11.927.500e−121787-1799BL00383Tyrosine specific
protein phosphatases
proteins.
1635BL00383D11.929.400e−131498-1510BL00383Tyrosine specific
protein phosphatases
proteins.
1635BL00383E10.351.000e−141536-1546BL00383Tyrosine specific
protein phosphatases
proteins.
1635BL00383E10.351.000e−141827-1837BL00383Tyrosine specific
protein phosphatases
proteins.
1635BL00383F15.517.120e−131865-1880BL00383Tyrosine specific
protein phosphatases
proteins.
1635BL00383F15.518.941e−161574-1589BL00383Tyrosine specific
protein phosphatases
proteins.
1635BL00621G22.331.250e−101225-1278BL00621Tissue factor proteins.
1635BL00790I20.011.536e−09663-693BL00790Receptor tyrosine
kinase class V
proteins.
1635BL00790I20.012.688e−10776-806BL00790Receptor tyrosine
kinase class V
proteins.
1635BL00790I20.012.800e−10467-497BL00790Receptor tyrosine
kinase class V
proteins.
1635BL00790I20.018.500e−12561-591BL00790Receptor tyrosine
kinase class V
proteins.
1635BL00790I20.019.735e−13967-997BL00790Receptor tyrosine
kinase class V
proteins.
1635PR00014B14.775.500e−09431-441PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1635PR00014C15.445.500e−10550-568PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1635PR00014C15.448.500e−14956-974PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1635PR00014D12.045.235e−10878-892PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1635PR00014D12.047.000e−11670-684PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1635PR00014D12.047.750e−09974-988PR00014FIBRONECTIN TYPE III
REPEAT SIGNATURE
1635PR00219C9.044.450e−091251-1270PR00219SYNAPTOBREVIN SIGNATURE
1635PR00346H10.741.214e−091250-1273PR00346TISSUE FACTOR SIGNATURE
1635PR00700A6.968.714e−111394-1401PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1635PR00700B16.801.500e−241410-1430PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1635PR00700B16.804.240e−211699-1719PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1635PR00700C13.175.800e−181494-1511PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1635PR00700C13.177.353e−171783-1800PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1635PR00700D12.474.214e−221533-1551PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1635PR00700D12.477.158e−201824-1842PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1635PR00700E17.574.000e−141855-1870PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1635PR00700E17.575.304e−121564-1579PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1635PR00700F11.181.429e−121871-1881PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1635PR00700F11.187.353e−131580-1590PR00700PROTEIN TYROSINE
PHOSPHATASE SIGNATURE
1636BL00152A15.385.154e−21134-159BL00152ATP synthase alpha and
beta subunits proteins.
1636BL00152B21.404.000e−32191-228BL00152ATP synthase alpha and
beta subunits proteins.
1636BL00152C11.416.250e−12291-302BL00152ATP synthase alpha and
beta subunits proteins.
1636BL00152D29.001.000e−40310-354BL00152ATP synthase alpha and
beta subunits proteins.
1636BL00152E22.681.000e−32362-399BL00152ATP synthase alpha and
beta subunits proteins.
1637BL000187.414.130e−0967-79BL00018EF-hand calcium-binding
domain proteins.
1637BL00303A21.776.667e−26 7-43BL00303S-100/ICaBP type
calcium binding
protein.
1637BL00303B26.151.000e−2455-91BL00303S-100/ICaBP type
calcium binding
protein.
1637PR00334B8.698.286e−09 90-113PR00334HMW KININOGEN SIGNATURE
1639BL00111A9.653.000e−1716-29BL00111Phosphoglycerate kinase
proteins.
1639BL00111B12.167.923e−1558-69BL00111Phosphoglycerate kinase
proteins.
1639BL00111C15.756.850e−2074-98BL00111Phosphoglycerate kinase
proteins.
1639BL00111D16.019.400e−16114-128BL00111Phosphoglycerate kinase
proteins.
1639BL00111E11.181.750e−26159-179BL00111Phosphoglycerate kinase
proteins.
1639BL00111F14.321.000e−40186-232BL00111Phosphoglycerate kinase
proteins.
1639BL00111G26.363.769e−34253-292BL00111Phosphoglycerate kinase
proteins.
1639BL00111H20.833.455e−31317-352BL00111Phosphoglycerate kinase
proteins.
1639BL00111I9.951.643e−14390-411BL00111Phosphoglycerate kinase
proteins.
1639BL00461B14.591.437e−09201-240BL004616-phosphogluconate
dehydrogenase proteins.
1639PR00477A7.933.769e−2013-29PR00477PHOSPHOGLYCERATE KINASE
FAMILY SIGNATURE
1639PR00477B14.504.857e−2234-56PR00477PHOSPHOGLYCERATE KINASE
FAMILY SIGNATURE
1639PR00477C14.676.400e−17114-129PR00477PHOSPHOGLYCERATE KINASE
FAMILY SIGNATURE
1639PR00477D12.941.900e−28157-179PR00477PHOSPHOGLYCERATE KINASE
FAMILY SIGNATURE
1639PR00477E11.953.500e−22186-208PR00477PHOSPHOGLYCERATE KINASE
FAMILY SIGNATURE
1639PR00477F7.638.000e−20209-228PR00477PHOSPHOGLYCERATE KINASE
FAMILY SIGNATURE
1639PR00477G15.401.000e−24333-358PR00477PHOSPHOGLYCERATE KINASE
FAMILY SIGNATURE
1639PR00477H5.936.000e−15369-380PR00477PHOSPHOGLYCERATE KINASE
FAMILY SIGNATURE
1640PR00477I8.534.000e−20392-409PR00477PHOSPHOGLYCERATE KINASE
FAMILY SIGNATURE
1640PR00360B13.611.818e−0940-53PR00360C2 DOMAIN SIGNATURE
1640PR00360B13.616.455e−111193-1206PR00360C2 DOMAIN SIGNATURE
1641BL00115A15.441.000e−4050-88BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115B15.422.957e−36 89-120BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115C14.014.750e−24182-203BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115D19.941.000e−40224-264BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115E14.138.560e−31297-325BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115F10.777.107e−36326-356BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115G11.652.000e−34357-384BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115H14.342.286e−35385-417BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115I8.331.000e−40443-497BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115J16.719.143e−31498-523BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115K15.031.000e−40524-565BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115L12.256.464e−37566-597BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115M19.191.000e−40622-664BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115N20.571.000e−40665-713BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115O16.761.000e−40735-784BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115P11.541.000e−40785-824BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Q18.082.575e−37825-854BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115R6.502.385e−32855-881BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115S18.246.333e−40882-923BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115T8.451.000e−401083-1116BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115U10.342.688e−261117-1139BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115V21.321.000e−401140-1189BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115W21.011.000e−401208-1253BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115X21.135.500e−351324-1359BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Y11.861.000e−401360-1405BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−081568-1616BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401604-1652BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401611-1659BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401618-1666BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401625-1673BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401632-1680BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401639-1687BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401646-1694BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401653-1701BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401660-1708BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401667-1715BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401674-1722BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401681-1729BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401688-1736BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401695-1743BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401702-1750BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401709-1757BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401716-1764BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401723-1771BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401730-1778BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401737-1785BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401744-1792BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins
1641BL00115Z3.121.000e−401751-1799BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401758-1806BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401765-1813BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401772-1820BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401779-1827BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401786-1834BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401793-1841BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401800-1848BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401814-1862BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401821-1869BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401828-1876BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401835-1883BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401842-1890BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401849-1897BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401856-1904BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401863-1911BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401870-1918BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401877-1925BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401884-1932BL00015Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.000e−401891-1939BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.493e−351597-1645BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.121.779e−171922-1970BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.122.636e−121561-1609BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.123.326e−241590-1638BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.123.380e−121554-1602BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.123.512e−101576-1624BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.124.030e−181583-1631BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.124.646e−301905-1953BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.125.760e−171908-1956BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.126.000e−231912-1960BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.126.302e−101894-1942BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.126.591e−401807-1855BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.127.154e−091547-1595BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.128.174e−381898-1946BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.128.566e−141901-1949BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.129.644e−181919-1967BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1641BL00115Z3.129.903e−221915-1963BL00115Eukaryotic RNA
polymerase II
heptapeptide repeat
proteins.
1643BL00298A10.971.000e−40 74-118BL00298Heat shock hsp90
proteins family
proteins.
1643BL00298B15.641.290e−39134-180BL00298Heat shock hsp90
proteins family
proteins.
1643BL00298C16.402.286e−40186-229BL00298Heat shock hsp90
proteins family
proteins.
1643BL00298D17.976.226e−33242-281BL00298Heat shock hsp90
proteins family
proteins.
1643BL00298E27.301.000e−40321-375BL00298Heat shock hsp90
proteins family
proteins.
1643BL00298F11.211.000e−40409-463BL00298Heat shock hsp90
proteins family
proteins.
1643BL00298G24.575.345e−39465-519BL00298Heat shock hsp90
proteins family
proteins.
1643BL00298H20.501.000e−40553-606BL00298Heat shock hsp90
proteins family
proteins.
1643BL00298I30.077.818e−34661-714BL00298Heat shock hsp90
proteins family
proteins.
1643BL00422C16.189.234e−10295-322BL00422Granins proteins.
1643PD01781B27.552.800e−09758-801PD01781PROTEASE IMMUNOGLOBULIN
PRECURSO.
1643PR00775A9.903.250e−2274-94PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1643PR00775B3.523.700e−26 95-117PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1643PR00775C10.683.727e−16144-161PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1643PR00775D8.919.640e−18162-179PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1643PR00775E8.066.571e−27192-214PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1643PR00775F12.762.800e−15243-260PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1643PR00775G10.649.625e−19261-279PR0077590 KD HEAT SHOCK
PROTEIN SIGNATURE
1644BL0029928.841.000e−4016-67BL00299Ubiquitin domain
proteins.
1644PF0102015.001.000e−40 80-128PF01020Ribosomal L40e family.
1644PR00348A7.862.000e−2611-31PR00348UBIQUITIN SIGNATURE
1644PR00348B5.782.800e−2732-52PR00348UBIQUITIN SIGNATURE
1644PR00348C20.031.643e−2753-74PR00348UBIQUITIN SIGNATURE
1646BL00646A25.826.192e−2914-61BL00646Ribosomal protein S13
proteins.
1646BL00646B21.426.100e−30110-142BL00646Ribosomal protein S13
proteins.
1647BL00358A13.069.690e−1119-29BL00358Ribosomal protein L5
proteins.
1647BL00358B22.762.742e−3840-85BL00358Ribosomal protein L5
proteins.
1647BL00358C13.755.500e−15 99-112BL00358Ribosomal protein L5
proteins.
1647BL00358D14.265.500e−14119-133BL00358Ribosomal protein L5
proteins.
1649BL00290A20.897.158e−1342-64BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1649BL00290B13.174.500e−12 98-115BL00290Immunoglobulins and
major
histocompatibility
complex proteins.
1650BL01121A9.119.100e−12 90-100BL01121Caspase family
histidine proteins.
1650BL01121B29.681.346e−26103-138BL01121Caspase family
histidine proteins.
1650BL01121C13.175.065e−15150-165BL01121Caspase family
histidine proteins.
1650BL01121D12.344.343e−19197-214BL01121Caspase family
histidine proteins.
1650BL01121E23.715.179e−31247-281BL01121Caspase family
histidine proteins.
1650BL01121F15.431.783e−12293-305BL01121Caspase family
histidine proteins.
1650PR00376A14.235.886e−14 88-101PR00376INTERLEUKIN-1B
CONVERTING ENZYME
SIGNATURE
1650PR00376B15.579.660e−11106-124PR00376INTERLEUKIN-1B
CONVERTING ENZYME
SIGNATURE
1650PR00376C16.285.574e−10124-142PR00376INTERLEUKIN-1B
CONVERTING ENZYME
SIGNATURE
1650PR00376D12.741.250e−10157-165PR00376INTERLEUKIN-1B
CONVERTING ENZYME
SIGNATURE
1650PR00376E12.265.941e−18197-215PR00376INTERLEUKIN-1B
CONVERTING ENZYME
SIGNATURE
1650PR00376F13.774.833e−11266-277PR00376INTERLEUKIN-1B
CONVERTING ENZYME
SIGNATURE
1651BL00525A11.574.971e−1112-30BL00525Ribosomal protein L6
proteins.
1651BL00700A19.349.308e−33 8-45BL00700Ribosonal protein L6
proteins 2.
1651BL00700B18.261.000e−40 62-100BL00700Ribosomal protein L6
proteins 2.
1651BL00700C11.764.000e−13112-121BL00700Ribosomal protein L6
proteins 2.
1651BL00700D21.511.000e−40141-184BL00700Ribosomal protein L6
proteins 2.
1652BL0005515.982.200e−24 90-125BL00055Ribosomal protein S12
proteins.
1653BL0029928.848.269e−3316-67BL00299Ubiquitin domain
proteins.
1653PR00348B5.782.000e−1532-52PR00348UBIQUITIN SIGNATURE
1653PR00348C20.038.477e−1453-74PR00348UBIQUITIN SIGNATURE
1654BL00024A11.495.000e−1175-85BL00024Hemopexin domain
proteins.
1654BL00024B21.533.432e−26104-137BL00024Hemopexin domain
proteins.
1654BL00024C22.981.000e−40152-200BL00024Hemopexin domain
proteins.
1654BL00024D17.284.375e−29206-237BL00024Hemopexin domain
proteins.
1654BL00024E7.582.406e−14245-258BL00024Hemopexin domain
proteins.
1654BL00024F11.306.786e−21298-318BL00024Hemopexin domain
proteins.
1654BL00024G13.312.333e−09429-441BL00024Hemopexin domain
proteins.
1654BL00024G13.319.308e−13336-348BL00024Hemopexin domain
proteins.
1654BL00024H11.352.174e−13355-366BL00024Hemopexin domain
proteins.
1654BL00024H11.353.600e−09401-412BL00024Hemopexin domain
proteins.
1654BL001428.382.636e−11212-222BL00142Neutral zinc
metallopeptidases,
zinc-binding region
proteins.
1654BL00546A19.628.154e−2155-84BL00546Matrixins cysteine
switch.
1654BL00546B20.111.000e−40153-196BL00546Matrixins cysteine
switch.
1654BL00546C16.412.575e−29206-237BL00546Matrixins cysteine
switch.
1654BL00546D10.342.459e−14245-258BL00546Matrixins cysteine
switch.
1654BL00546E10.239.727e−21298-318BL00546Matrixins cysteine
switch.
1654BL00546F12.406.700e−13336-348BL00546Matrixins cysteine
switch.
1654BL00546F12.408.059e−10429-441BL00546Matrixins cysteine
switch.
1654BL00546G16.842.091e−15356-375BL00546Matrixins cysteine
switch.
1654BL00546G16.843.368e−09310-329BL00546Matrixins cysteine
switch.
1654BL00546H10.761.514e−10448-458BL00546Matrixins cysteine
switch.
1654BL00546H10.766.333e−11401-411BL00546Matrixins cysteine
switch.
1654PR00138A15.147.000e−1375-88PR00138MATRIXIN SIGNATURE
1654PR00138B15.826.625e−16130-145PR00138MATRIXIN SIGNATURE
1654PR00138C16.419.053e−33153-181PR00138MATRIXIN SIGNATURE
1654PR00138D16.566.921e−25212-237PR00138MATRIXIN SIGNATURE
1654PR00138E6.012.091e−14245-258PR00138MATRIXIN SIGNATURE
1654PR00480B15.415.355e−11207-225PR00480ASTACIN FAMILY
SIGNATURE
1656PR00449E13.508.313e−1868-90PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1657BL01160B19.542.068e−09139-192BL01160Kinesin light chain
repeat proteins.
1657PF00850D14.765.846e−16829-852PF00850Histone deacetylase
family.
1657PF00850E8.888.071e−23863-888PF00850Histone deacetylase
family.
1657PF00850F15.701.556e−10901-933PF00850Histone deacetylase
family.
1657PF00850G22.759.250e−11940-981PF00850Histone deacetylase
family.
1658BL00720B16.576.516e−17347-370BL00720Guanine-nucleotide
dissociation
stimulators CDC25
family sign.
1658PR00761E14.329.500e−1038-56PR00761BINDIN PRECURSOR
SIGNATURE
1659BL01267A18.077.618e−2812-40BL01267Uncharacterized protein
family UPF0023
proteins.
1659BL01267B18.766.936e−3141-81BL01267Uncharacterized protein
family UPF0023
proteins.
1659BL01267C22.809.348e−23125-178BL01267Uncharacterized protein
family UPF0023
proteins.
1660BL01100A12.621.947e−2412-38BL01100NNMT/PNMT/TEMT family
of methyltransferases
proteins.
1660BL01100B12.731.000e−4042-85BL01100NNMT/PNMT/TEMT family
of methyltransferases
proteins.
1660BL01100C10.346.211e−24 86-107BL01100NNMT/PNMT/TEMT family
of methyltransferases
proteins.
1660BL01100D14.779.357e−23110-134BL01100NNMT/PNMT/TEMT family
of methyltransferases
proteins.
1660BL01100E12.251.000e−40156-199BL01100NNMT/PNMT/TEMT family
of methyltransferases
proteins.
1660BL01100F14.306.595e−28200-232BL01100NNMT/PNMT/TEMT family
of methyltransferases
proteins.
1660BL01100G14.709.780e−19238-259BL01100NNMT/PNMT/TEMT family
of methyltransferases
proteins.
1661BL0054820.587.000e−1966-95BL00548Ribosomal protein S3
proteins.
1661BL00765A13.271.000e−08158-178BL00765Phosphoglucose
isomerase proteins.
1661PF000135.784.706e−1058-69PF00013KH domain proteins
family of RNA binding
proteins.
1662PD01733B20.444.375e−09410-464PD01733APOLIPOPROTEIN PLASMA
LIPID TRANSPORT H.
1663BL0026714.218.667e−1081-90BL00267Tachykinin family
proteins.
1664DM00372A19.181.000e−4019-63DM00372CARCINOEMBRYONIC
ANTIGEN PRECURSOR
AMINO-TERMINAL DOMAIN.
1664DM00372B20.319.229e−38 82-126DM00372CARCINOEMBRYONIC
ANTIGEN PRECURSOR
AMINO-TERMINAL DOMAIN.
1664DM00372C23.692.552e−28321-356DM00372CARCINOEMBRYONIC
ANTIGEN PRECURSOR
AMINO-TERMINAL DOMAIN.
1664PD01270D24.661.000e−09378-413PD01270RECEPTOR FC
IMMUNOGLOBULIN AFFIN.
1665DM01269A23.351.600e−2068-95DM01269303 kw ACTIVATING RAN
GTPASE ISOZYME.
1665DM01269B11.713.323e−09138-147DM01269303 kw ACTIVATING RAN
GTPASE ISOZYME.
1665PF0063811.914.600e−1867-81PF00638RanBP1 domain proteins.
1666BL00633B13.827.097e−16166-190BL00633Bromodomain proteins.
1666PR00503B9.969.571e−13165-181PR00503BROMODOMAIN SIGNATURE
1666PR00503C19.847.563e−09181-199PR00503BROMODOMAIN SIGNATURE
1666PR00503D20.812.313e−11199-218PR00503BROMODOMAIN SIGNATURE
1670BL0028216.888.875e−12464-486BL00282Kazal serine protease
inhibitors family
proteins.
1670BL00612A12.093.136e−11 3-18BL00612Osteonectin domain
proteins.
1670BL00612B11.356.625e−29431-463BL00612Osteonectin domain
proteins.
1670BL00612C9.901.000e−40496-543BL00612Osteonectin domain
proteins.
1670BL00612D10.061.000e−40563-613BL00612Osteonectin domain
proteins.
1670BL00612E13.121.000e−40617-661BL00612Osteonectin domain
proteins.
1671BL00061A9.416.684e−1183-93BL00061Short-chain
dehydrogenases/reductases
family proteins.
1671BL00061B25.797.158e−19136-173BL00061Short-chain
dehydrogenases/reductases
family proteins.
1671PR00080A9.329.667e−1183-94PR00080ALCOHOL DEHYDROGENASE
SUPERFAMILY SIGNATURE
1671PR00080C17.162.125e−10156-175PR00080ALCOHOL DEHYDROGENASE
SUPERFAMILY SIGNATURE
1671PR00081A10.537.000e−12 5-22PR00081GLUCOSE/RIBITOL
DEHYDROGENASE FAMILY
SIGNATURE
1671PR00081B10.383.368e−1083-94PR00081GLUCOSE/RIBITOL
DEHYDROGENASE FAMILY
SIGNATURE
1671PR00081C15.136.586e−10130-146PR00081GLUCOSE/RIBITOL
DEHYDROGENASE FAMILY
SIGNATURE
1672BL00139A10.291.000e−14132-141BL00139Eukaryotic thiol
(cysteine) proteases
cysteine proteins.
1672BL00139B10.196.571e−09175-183BL00139Eukaryotic thiol
(cysteine) proteases
cysteine proteins.
1672BL00139C9.232.800e−10275-284BL00139Eukaryotic thiol
(cysteine) proteases
cysteine proteins.
1672BL00139D9.241.818e−18295-311BL00139Eukaryotic thiol
(cysteine) proteases
cysteine proteins.
1672PD01919E19.317.582e−1073-98PD01919PROTEIN PROCESSING
TRANSPORT CAPSID
ASSEMBLY PR.
1672PR00704C11.886.162e−09132-148PR00704CALPAIN CYSTEINE
PROTEASE (C2) FAMILY
SIGNATURE
1672PR00705A10.554.000e−21132-147PR00705PAPAIN CYSTEINE
PROTEASE (C1) FAMILY
SIGNATURE
1672PR00705B10.222.385e−10276-286PR00705PAPAIN CYSTEINE
PROTEASE (C1) FAMILY
SIGNATURE
1673BL00610A17.731.000e−40 60-109BL00610Sodium: neurotransmitter
symporter family
proteins.
1673BL00610B23.651.000e−40123-172BL00610Sodium: neurotransmitter
symporter family
proteins.
1673BL00610C12.941.000e−40233-284BL00610Sodium: neurotransmitter
symporter family
proteins.
1673BL00610D20.971.000e−40299-351BL00610Sodium: neurotransmitter
symporter family
proteins.
1673BL00610E20.343.423e−39392-434BL00610Sodium: neurotransmitter
symporter family
proteins.
1673BL00610F29.021.000e−40491-545BL00610Sodium: neurotransmitter
symporter family
proteins.
1673BL00610G12.894.706e−25551-573BL00610Sodium: neurotransmitter
symporter family
proteins.
1673PR00176A16.828.500e−2860-81PR00176SODIUM/NEUROTRANSMITTER
SYMPORTER SIGNATURE
1673PR00176B7.317.250e−18 89-108PR00176SODIUM/NEUROTRANSMITTER
SYMPORTER SIGNATURE
1673PR00176C10.848.714e−27132-158PR00176SODIUM/NEUROTRANSMITTER
SYMPORTER SIGNATURE
1673PR00176D9.021.783e−19260-277PR00176SODIUM/NEUROTRANSMITTER
SYMPORTER SIGNATURE
1673PR00176E11.417.000e−21342-362PR00176SODIUM/NEUROTRANSMITTER
SYMPORTER SIGNATURE
1673PR00176F10.732.333e−20396-415PR00176SODIUM/NEUROTRANSMITTER
SYMPORTER SIGNATURE
1673PR00176G12.487.857e−20480-500PR00176SODIUM/NEUROTRANSMITTER
SYMPORTER SIGNATURE
1673PR00176H15.275.500e−21520-540PR00176SODIUM/NEUROTRANSMITTER
SYMPORTER SIGNATURE
1674BL00309C18.651.621e−0962-86BL00309Vertebrate galactoside-
binding lectin
proteins.
1675BL00113A12.749.585e−09157-173BL00113Adenylate kinase
proteins.
1675BL00690A6.873.455e−12160-169BL00690DEAH-box subfamily ATP-
dependent helicases
proteins.
1675BL00690B13.384.938e−18191-208BL00690DEAH-box subfamily ATP-
dependent helicases
proteins.
1675BL00690C7.518.650e−11257-266BL00690DEAH-box subfamily ATP-
dependent helicases
proteins.
1675DM004067.739.514e−10392-404DM00406GLIADIN.
1676BL0108220.373.500e−0947-86BL01082Ribosomal protein L7Ae
proteins.
1676BL01189A14.271.000e−4035-70BL01189Ribosomal protein S12e
proteins.
1676BL01189B13.491.000e−40 71-124BL01189Ribosomal protein S12e
proteins.
1676PR00972A8.016.625e−1721-34PR00972RIBOSOMAL PROTEIN S12E
FAMILY SIGNATURE
1676PR00972B8.629.000e−2135-51PR00972RIBOSOMAL PROTEIN S12E
FAMILY SIGNATURE
1676PR00972C10.311.500e−2676-97PR00972RIBOSOMAL PROTEIN S12E
FAMILY SIGNATURE
1676PR00972D10.151.000e−18101-114PR00972RIBOSOMAL PROTEIN S12E
FAMILY SIGNATURE
1677PF0004321.833.647e−2254-83PF00043Glutathione S-
transferases.
1677PR00455B17.475.227e−0960-83PR00455TETR BACTERIAL
REGULATORY PROTEIN HTH
SIGNATURE
1678BL00501A21.027.333e−18106-131BL00501Signal peptidases I
serine proteins.
1678BL00501B12.589.735e−11132-147BL00501Signal peptidases I
serine proteins.
1678BL00501C9.614.000e−10156-167BL00501Signal peptidases I
serine proteins.
1678BL00501D16.691.000e−15179-198BL00501Signal peptidases I
serine proteins.
1678PR00728A13.141.750e−20125-140PR00728EUKARYOTIC SIGNAL
PEPTIDASE (S27) FAMILY
SIGNATURE
1678PR00728B11.121.000e−15184-195PR00728EUKARYOTIC SIGNAL
PEPTIDASE (S27) FAMILY
SIGNATURE
1683BL01019A13.203.859e−1057-96BL01019ADP-ribosylation
factors family
proteins.
1683BL01115A10.229.735e−1223-66BL01115GTP-binding nuclear
protein ran proteins.
1683PR00449A13.203.400e−1523-44PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1683PR00449B14.342.800e−1046-62PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1683PR00449C17.278.941e−1964-86PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1683PR00449D10.793.864e−12126-139PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1683PR00449E13.506.478e−15161-183PR00449TRANSFORMING PROTEIN
P21 RAS SIGNATURE
1684BL00604A9.138.842e−20 49-103BL00604Synaptophysin/
synaptoporin proteins.
1684BL00604B9.951.329e−19114-143BL00604Synaptophysin/
synaptoporin proteins.
1684BL00604C14.665.639e−12144-175BL00604Synaptophysin/
synaptoporin proteins.
1684BL00604D12.285.410e−11176-210BL00604Synaptophysin/
synaptoporin proteins.
1684BL00604E8.321.444e−23210-251BL00604Synaptophysin/
synaptoporin proteins.
1684PR00220A10.938.244e−2446-68PR00220SYNAPTOPHYSIN/SYNAPTOPORIN
FAMILY SIGNATURE
1684PR00220B15.484.462e−2470-95PR00220SYNAPTOPHYSIN/SYNAPTOPORIN
FAMILY SIGNATURE
1684PR00220C11.054.477e−25127-151PR00220SYNAPTOPHYSIN/SYNAPTOPORIN
FAMILY SIGNATURE
1684PR00220D8.327.585e−26159-182PR00220SYNAPTOPHYSIN/SYNAPTOPORIN
FAMILY SIGNATURE
1684PR00220E3.466.932e−23225-243PR00220SYNAPTOPHYSIN/SYNAPTOPORIN
FAMILY SIGNATURE
1685BL001428.385.909e−11352-362BL00142Neutral zinc
metallopeptidases,
zinc-binding region
proteins.
1685BL0042713.936.918e−24449-503BL00427Disintegrins proteins.
1685PR00289A13.625.000e−19463-482PR00289DISINTEGRIN SIGNATURE
1685PR00289B11.792.500e−12492-504PR00289DISINTEGRIN SIGNATURE
1685PR00480B15.418.500e−10347-365PR00480ASTACIN FAMILY
SIGNATURE
1686BL00421A11.794.600e−1567-85BL00421Transmembrane 4 family
proteins.
1686BL00421B17.629.000e−34118-156BL00421Transmembrane 4 family
proteins.
1686BL00421C12.892.333e−11203-214BL00421Transmembrane 4 family
proteins.
1686BL00421E20.974.500e−21287-316BL00421Transmembrane 4 family
proteins.
1686PR00174A8.678.105e−0971-93PR00174LACY PROTON/SUGAR
SYMPORTER SIGNATURE
1686PR00259A9.272.742e−2171-94PR00259TRANSMEMBRANE FOUR
FAMILY SIGNATURE
1686PR00259B14.816.727e−23112-138PR00259TRANSMEMBRANE FOUR
FAMILY SIGNATURE
1686PR00259C16.401.265e−22139-167PR00259TRANSMEMBRANE FOUR
FAMILY SIGNATURE
1686PR00259D13.506.250e−23290-316PR00259TRANSMEMBRANE FOUR
FAMILY SIGNATURE
1688BL00291A4.495.345e−09138-172BL00291Prion protein.
1688BL00291A4.497.724e−09132-166BL00291Prion protein.
1688DM017248.144.553e−09156-175DM01724kw ALLERGEN POLLEN CIM1
HOL-LI.
1689PD01861A14.064.836e−1160-83PD01861PROTEIN NUCLEAR
RIBONUCLEOPROTEIN SMALL
MRNA RNA.
1691BL00107A18.396.760e−13280-310BL00107Protein kinases ATP-
binding region
proteins.
1691BL00107B13.311.000e−14344-359BL00107Protein kinases ATP-
binding region
proteins.
1691DM00191A8.164.840e−09663-675DM00191w SPAC8A4.04C
RESISTANCE SPAC8A4.05C
DAUNORUBICIN.
|
Example 6
Prediction of Signal Peptide Sequences contained in the Polypeptides of the Invention
The signal peptide regions for a plurality of the polypeptides of the invention were predicted using the Neural Network SignalP V1.1 program (Nielsen et al, (1997) Int. J. Neural Syst. 8, 581-599 herein incorporated by reference). One of skill in the art will recognize that the actual cleavage site may be different than that predicted by the computer program. The following table depicts the polypeptides of the invention that are predicted to have an N-terminal signal peptide, and lists the output from the SignalP program:
TABLE 5
|
|
SEQ ID NO:Max_scoreMean_scoreCleavage_Position
|
|
8650.9790.87934
8700.8960.68523
8760.9790.85433
8930.9410.83815
8950.9890.61944
8970.9540.80525
8980.8970.48621
9040.9590.82628
9060.9310.72930
9190.9580.60839
9210.9800.93226
9230.9700.87222
9300.9430.60223
9340.8970.67823
9370.9560.59743
9380.8820.54725
9390.9670.53216
9420.9260.50936
9430.8960.54025
9540.9970.95136
9590.9790.75139
9600.9830.63736
9640.9640.81926
9680.9430.64538
9690.9690.59730
9700.9580.82130
9730.9450.58737
9740.9100.62325
9880.9910.97127
9940.9140.62826
9990.9700.65921
10000.9580.52649
10040.9790.94119
10160.9870.92623
10250.8940.56128
10300.9940.96530
10330.9620.86526
10400.9410.80532
10410.9810.79545
10450.9350.83326
10460.9620.55846
10510.9860.59749
10580.9750.90119
10600.9330.70517
10620.9820.51349
10630.9390.54533
10660.9450.75447
10670.9440.81925
10720.9890.67344
10850.9740.51249
10870.9580.77016
10940.9680.57136
10950.9680.61742
10960.9760.89325
11020.9610.93320
11030.9320.55219
11140.9800.56847
11150.9900.81522
11190.9850.93521
11300.9550.66137
11340.9850.61421
11380.9750.87234
11400.9650.74923
11490.9600.77518
11510.9910.72734
11550.9820.49647
11560.9440.79429
11600.9470.60347
11620.9540.74531
11640.9270.65143
11940.9480.68027
12010.9570.89918
12070.9750.93518
12100.9770.93526
12110.9850.82247
12240.9830.90421
12280.9510.54447
12380.9660.71345
12550.9390.49539
12630.9910.61946
12660.9920.80639
12710.9290.66634
12790.9660.85720
12800.9210.77728
12820.9930.92719
12830.9950.86722
12860.9650.89418
12870.9860.93524
12880.9790.73332
12910.9870.78528
13040.9200.71224
13070.9270.58645
13080.9790.96318
13090.9630.84024
13100.9670.83922
13140.9950.92923
13160.9780.87324
13310.9750.88819
13320.9610.79629
13330.9650.87327
13390.9100.63125
13420.9730.88434
13460.9330.72529
13560.9750.82134
13650.9290.63239
13670.9620.91922
13760.9550.84933
13840.9870.57639
13890.9840.88926
13900.9800.55936
13950.9740.93322
13960.9670.94116
13980.9430.82924
14020.9690.72141
14030.9340.81526
14050.9200.50522
14090.9850.93924
14120.9630.87829
14170.9570.64035
14180.9460.87318
14190.9750.64537
14200.9760.86724
14210.9850.91720
14290.9800.90817
14300.9100.71228
14310.9840.93922
14330.9740.90820
14370.9660.54238
14380.9810.94127
14450.9590.77126
14490.9880.89718
14520.9660.78231
14550.9780.94422
14560.9500.91919
14580.9740.91322
14650.9830.95722
14670.9770.93720
14710.9060.60122
14780.9590.49145
14790.9680.88324
14800.9760.91622
14840.9810.89728
14850.9720.95617
14880.9830.83820
14890.9650.86918
14920.9140.67717
14950.9450.82521
14960.9930.97516
14980.9570.89119
15000.9840.83233
15090.9960.92142
15120.9770.83516
15150.9860.94520
15180.9780.88526
15200.9960.92422
15270.9550.52146
15280.9910.50248
15320.9890.90317
15330.9870.97115
15360.9830.95617
15380.9780.91525
15390.9830.94020
15400.9650.79928
15420.9810.86526
15450.9390.5029
15490.9660.90226
15510.9900.96516
15520.9910.92718
15540.9790.89531
15570.9630.88424
15590.9770.92224
15600.9690.90127
15610.9800.94625
15650.9820.88624
15680.9620.80127
15750.9840.95818
15760.9380.81825
15810.9630.88723
15830.9700.93513
15850.9000.64134
15870.9680.90219
15900.9810.95520
15920.9660.90927
15940.9700.93115
15970.9770.90523
16130.9700.91022
16180.9760.84021
16190.9820.90831
16220.9780.87926
16250.9290.80524
16310.9910.97216
16330.9790.87128
16350.9590.81619
16360.9180.69213
16430.9900.90121
16490.9620.92120
16540.9790.86531
16630.9890.96616
16670.9800.91637
16690.9530.49634
16700.9880.95116
16720.9660.91317
16810.9270.67120
16850.9670.59336
16950.9860.91918
16970.8980.71624
17020.9400.83719
17030.9940.62043
|
Example 7
Prediction of Transmembrane Regions of the Polypeptides of the Invention
Regions of the polypeptides of the invention that cross a cellular lipid bilayer or membrane were predicted using the TMPRED computer program (Hofmann et al. Biol. Chem. Hoppe-Seyler 374,166 hereby incorporated herein by reference). The following table describes the plurality of polypeptides of the invention that contain at least one predicted transmembrane domain:
TABLE 6
|
|
Number of
PredictedDomain
TransmembraneTotalLocation:
SEQ ID NO:RegionsScoreScore
|
|
85412088115-138: 2088
86461266056-78: 2631
150-169: 1686
243-258: 1737
336-359: 1556
379-394: 2572
456-473: 2478
87111947434-454: 1947
8734847953-69: 2714
136-152: 2014
203-220: 1906
509-526: 1845
87511722118-138: 1722
8784752768-86: 1551
105-123: 1875
272-290: 1556
340-356: 2545
879611423127-148: 1678
281-300: 2640
393-412: 1662
427-447: 1670
543-559: 2249
638-653: 1524
88648588104-120: 2019
243-267: 2346
335-350: 2222
401-425: 2001
89437997141-156: 3090
167-190: 1601
207-226: 3306
8961264244-66: 2642
8981257887-106: 2578
90811569958-974: 1569
91413089502-524: 3089
91812577469-485: 2577
91912819233-254: 2819
92636476161-177: 2207
254-270: 2180
449-467: 2089
92912228121-136: 2228
934612682172-187: 2293
237-258: 2056
279-299: 1759
329-351: 2812
371-386: 2117
408-429: 1645
93712548248-264: 2548
9391218193-114: 2181
9412348089-110: 1685
135-154: 1795
94612450385-401: 2450
9571215197-117: 2151
96035457598-614: 1857
707-724: 1544
748-764: 2056
9682466149-71: 2672
165-185: 1989
9694784389-105: 2039
164-183: 2176
224-243: 1514
282-299: 2114
97112123100-118: 2123
97812143135-148: 2143
9791213149-66: 2131
98611710128-143: 1710
98911979112-130: 1979
99711929288-303: 1929
99913084178-199: 3084
10051307273-90: 3072
100813073641-660: 3073
101212019910-925: 2019
101513454396-416: 3454
101613369581-605: 3369
101711618644-663: 1618
102761301380-96: 2887
150-169: 2073
227-243: 2086
307-324: 1960
404-419: 1773
481-495: 2234
10281179092-107: 1790
10301171063-86: 1710
10351250694-111: 2506
104011561718-733: 1561
10414835071-88: 1896
291-307: 2812
387-406: 1755
474-490: 1887
106213368258-278: 3368
106512643336-358: 2643
10661240649-70: 2406
106712700493-510: 2700
107324203135-168: 2597
200-214: 1606
10754687450-66: 1560
139-155: 1995
190-213: 1787
291-305: 1532
108037420116-132: 2923
197-212: 2709
223-239: 1788
108512097195-216: 2097
10881199674-89: 1996
109071348468-88: 2007
105-119: 1501
141-159: 1687
220-238: 2030
296-311: 2033
395-410: 1727
452-471: 2499
110112000403-423: 2000
110213504743-764: 3504
110512219351-369: 2219
110661212068-88: 2342
128-145: 1914
185-206: 1521
312-329: 2024
365-380: 2531
433-448: 1788
11111151751-68: 1517
111313180356-380: 3180
11161220656-75: 2206
11242409183-111: 2452
130-148: 1639
112512998160-181: 2998
112913163779-799: 3163
113012744102-126: 2744
113312029112-129: 2029
113412206736-757: 2206
11401275087-99: 2750
114212922105-123: 2922
114813113294-316: 3113
116459520483-502: 1826
516-531: 1837
584-605: 2275
626-642: 1515
674-690: 2067
116561186092-112: 2331
121-141: 1535
209-230: 2031
336-353: 1755
389-406: 2107
457-472: 2101
116647475164-179: 1986
229-248: 2015
254-269: 1577
286-306: 1897
1168612530109-122: 2345
195-212: 1649
344-366: 2101
424-439: 2493
455-474: 2000
476-496: 1942
117012318349-376: 2318
11751158290-108: 1582
117611516742-764: 1516
117912508135-154: 2508
11851164958-74: 1649
119012235296-312: 2235
11941282344-70: 2823
119612041187-202: 2041
11991378899-116: 3788
120111553551-566: 1553
120748078134-150: 2201
237-258: 1652
375-397: 2178
484-501: 2047
121012222118-132: 2222
12331170449-67: 1704
12551267784-106: 2677
12663733059-76: 2685
90-108: 1580
195-221: 3065
127123771634-650: 1766
691-709: 2005
12732481485-105: 2193
216-241: 2621
12803601158-74: 2642
171-188: 1509
228-250: 1860
130111651112-131: 1651
130411960187-209: 1960
130812729212-229: 2729
130912154564-579: 2154
13161163490-105: 1634
132011847134-150: 1847
13222540383-98: 2412
160-175: 2991
132412129128-147: 2129
132711645115-131: 1645
133312378122-138: 2378
13341268152-76: 2681
134211520365-380: 1520
134312312139-155: 2312
135612292101-129: 2292
137611606606-621: 1606
137748637100-113: 2419
294-313: 2702
787-808: 1889
985-1001: 1627
137925222197-218: 2416
277-297: 2806
138012398102-120: 2398
138949882177-192: 3257
235-261: 2052
276-291: 1761
363-381: 2812
13932445666-82: 2701
110-126: 1755
139523335263-279: 1511
325-342: 1824
14001179395-113: 1793
140224648229-245: 1641
313-333: 3007
14172380292-114: 2061
152-175: 1741
142561342059-75: 1823
112-127: 3392
132-147: 1707
180-193: 2193
231-246: 1810
331-346: 2495
14281192360-78: 1923
143413041111-129: 3041
143624541103-118: 2057
295-309: 2484
144411540257-275: 1540
144512610199-219: 2610
144936892143-158: 1938
181-198: 2860
270-289: 2094
145512481241-256: 2481
1459510350115-133: 2128
183-195: 2109
229-245: 1520
288-307: 2678
356-372: 1915
14781228156-71: 2281
148412689229-245: 2689
149512478146-162: 2478
14962576168-84: 2749
144-163: 3012
15003614481-99: 2768
118-132: 1551
166-182: 1825
15111152876-91: 1528
151511775201-233: 1775
15161333571-93: 3335
152335593128-145: 1794
348-365: 1730
438-455: 2069
155611521147-166: 1521
155912828628-650: 2828
156512718306-332: 2718
15671266054-72: 2660
157411922504-519: 1922
157512773306-332: 2773
157612661218-239: 2661
158312635352-369: 2635
158713196518-538: 3196
15891205978-99: 2059
159348614164-178: 2254
259-274: 2312
325-340: 2378
392-410: 1670
159412673339-357: 2673
161612581120-136: 2581
161813544324-344: 3544
161911551695-711: 1551
162211516765-780: 1516
1635136941258-1274: 3694
163811606105-121: 1606
1640140132045-2062: 4013
16451172280-96: 1722
16551239268-90: 2392
167381447561-80: 1745
129-154: 1690
235-251: 1560
262-277: 1971
350-368: 2264
398-415: 1642
521-537: 1609
559-577: 1994
168012286145-162: 2286
168436111131-149: 2670
162-176: 1558
223-243: 1883
168513127709-725: 3127
16864844373-88: 2001
114-132: 2487
143-168: 1531
288-311: 2424
168712972285-303: 2972
17011320688-113: 3206
|
Example 8
Prediction of Chromosomal Location of the Polynucleotides of the Invention
Chromosomal location of the polynucleotide sequences of the invention was determined by using the BLASTN algorithm (Altschul et al. Nucleic Acids Res. 25 pp. 3389-3402 herein incorporated by reference). SEQ ID NO: 1 through 852 were aligned to the sequence of the human genome (Version date Nov. 3, 2002 from Genbank) using the BLASTN computer program. The chromosomal locations of the aligned human genome sequences were determined through the Genbank accession numbers of the aligned human genome sequences, which enabled retrieval of annotated chromosomal location from the Genbank database. The following table depicts the predicted chromosomal location of the polynucleotides of the invention (SEQ ID NO 1 through 852).
TABLE 7
|
|
SEQ ID NO:Chromsomal_location
|
|
111q
211q
310
43
616
715
86
105
121
1315
147
185
191
2014
2111
22Xp11.3-11.4
2311
2519
261
2811
2919
329
3417
3519
363
3717
384
404
416
432
4419
4511
46X
471
4920
501
515
521
5319
5519
564
574
5911q
6017
6210
635
6415
6516
6720
68Xq22.1-23
7010
718
7221
732
758
763
779
787
7919
8016
813
825
8313
841p36.11-36.31
851p32.1-33
861p36.11-36.31
878
883
8915
906p24.1-25.3
911
943
9520
9617
974
9919
1012
10311q
1042
105X
10619
1084
10913q12.11-12.3
11017
11112
1122
113X
1143
11710
1185
11916
12019
121X
1221
1235
12412
1251
12616
12711q
1281
1294
1309q13-21.2
13110
13219
13310
13413
13517
13611q
1378
1382
1405
1416
1421
14319
1445
1463
1475
14811
1497
15119
15214
15416
1553
15616
1579p23-24.3
16020
16210
1631
16420p11.1-11.23
1653
1665
1671
1686
16914
17010
1718
17211
1737
1743
1752
1761p36.21-36.33
17719
1801q25.1-25.3
181X
1834
1847
18510
18619
18711q
18810
189Xp
19116
1928
1932
1953p
1961
19713
1986q26-27
19913
20111
2024
2034
20411
2055
2061
20716
2083
20920
2103
21211
2131
21420
2158
21611q
21711q
21813
2193
22219
22316
22420
2263
2279q22.1-22.33
22812
2296p12.3-21.2
23011q
2337
2351
2367
23712
23814
23910
24019
24122q11.2
2428
2431q24
24417
2454
2467
24717
2496
25018
2511
2521
2531
255Xq23
25612
2581
25922
260X
2611p31.2-32.3
2636
2643
26517
26616
26810
2702
2712
2729
2735
2741
2759
2761
27718
27821
28112
2821
2845
2853
2865
28712
2896
2903
29110
29216
2933
2941p31.2-32.3
2954
29611q
2979
29810
29919
3007
3022
3031
30417
30514
3066q22.22-23.3
30711
30816
3105
31219
3131
3146
31519
31616
31712
3206
32112
3221
32415
32510
3264
32711
3281
3291q24.1-25.2
3309
3326q14.2-16.1
33319
3347
33519
3365
33822
33922
3401
3413
34216
3439
34419
3455
34620p11.21-11.23
347Xp11.4-21.2
3488
3497
35117
3526
3541
3552
35911
3619
36811
37020
37417
3819
3875
3888
3899
39116
3931
3955
39619
3992
4001
4075
4103
4136
4151
4175
41916
42010
4216
424X
4291
4319
43314
4341
4351
4363
4375
4387
44111
44514
44610
4481
44919
450X
451X
45510
457Xq25-Xq26
46014
46117
46315
4663
46818
47110
47311
4741
4775
4783
48019
48810
4955
49819
5001
5059
5062
5071
5098
516X
5201
5221p36.1-36.2
5261p36.13-36.31
5315
5327
5335
5355
5409
54516
54812
5498
5577
5594
5612
5621p35.1-36.13
5633
5643
56612
57010
5713
5723
57315
57413
5824
58511
5861
5913
59214
5951
59619
5973
59811
60112
6041
60611
60717
60911
61117
61310
6183
61916
6248
6273p21.3
62910
6316
6373
6386q16-21
63911q
6412
64611
6487
6514
6544
6559
65614
660X
6636
6676
66912
67020p12.1-13
67111
6721
67611
68220
68719
68917
6932
6969
69911
70315
70414
70517
7071
7101
7141
71521q21.1-q21.2
7175
71822
7209
72111
72512q
72616
72716
72811
73319
7371
73919
74219
74614
7483
7491
75220
7546
75518
7567
76019
765Xq22.1-22.3
76617
7681
7703
77111
77210
77519
77619
77714
7783
78217
7831
787Xq12-13.1
78917
7911
7931
7943
79915
800X
80419
80811
8093
81219
813X
8146
8184
82411q
82615
82917
8305
83111
8338
83411
83522q12.2-13.1
83618
83921q22.2
|
Example 9
Purification of the Polypeptides of the Invention
The polypeptides of the invention can be produced by first cloning the corresponding polynucleotides of the invention into a mammalian expression vector using established protocols that are familiar to those in skill of the art (for example, pCDNA3.1/His A, B, C Catalog Number V385-20 from Invitrogen, Carlsbad, Calif., herein incorporated by reference). Briefly, polynucleotides of the invention are amplified and isolated via agarose gel electrophoresis and gel excision. The polynucleotides are subsequently cloned into the pCDNA3.1/His A, B, C vectors to facilitate in-frame cloning with a polyhistidine metal-binding tag. The vectors with polynucleotides of the invention inserted can then be transfected into a mammalian cell line like COS-7 for high-level expression of the corresponding polypeptides of the invention.
The corresponding polypeptides of the invention that are produced by the transfected mammalian cell line can then be purified according to established protocols that are familiar to those of skill in the art (for example, the Ni-NTA Magnetic Agarose Beads protein purification protocol, Qiagen, Valencia, Calif., herein incorporated by reference). Briefly, assays utilizing Ni-NTA Magnetic Beads involve capture of the 6×His-tagged protein—from a cell lysate or a purified-protein solution—followed by washing, binding of interaction partners, further washing, and finally elution of the interacting partner from the still immobilized 6×His-tagged protein or elution of the interacting-partner-6×His-tagged-protein complex. Between each step, the beads are collected by attracting them to the side of the vessel, after placing near a magnet for 30-60 seconds. Purification procedures may even use crude cell extracts for binding of 6×His-tagged protein.
The resulting purified polypeptides of the invention are then quantified, lyophilized and stored at 4 degrees Celcius or below, and used for standards in diagnostic kits for pre-eclampsia.
Example 10
Production of Specific Antibodies for the Polypeptides of the Invention
Cells expressing any of the polypeptides of the invention are identified using antibodies specific for SEQ ID NO: 853 through 1704. Polyclonal antibodies are produced by DNA vaccination or by injection of peptide antigens into rabbits or other hosts. An animal, such as a rabbit, is immunized with a peptide specific for one of SEQ ID NO: 853 through 1704 conjugated to a carrier protein, such as BSA (bovine serum albumin) or KLH (keyhole limpet hemocyanin). The rabbit is initially immunized with conjugated peptide in complete Freund's adjuvant, followed by a booster shot every two weeks with injections of conjugated peptide in incomplete Freund's adjuvant. Antibodies specific for a polypeptide of the invention are affinity purified from rabbit serum using peptides corresponding to the polypeptides of the invention coupled to Affi-Gel 10 (Bio-Rad), and stored in phosphate-buffered saline with 0.1% sodium azide. To determine that the polyclonal antibodies are specific for a polypeptide of the invention, an expression vector encoding a polypeptide of the invention is introduced into mammalian cells. Western blot analysis of protein extracts of non-transfected cells and the cells containing a polypeptide of the invention is performed using the polyclonal antibody sample as the primary antibody and a horseradish peroxidase-labeled anti-rabbit antibody as the secondary antibody. Detection of a band in the cells containing a polypeptide of the invention and lack thereof in the control cells indicates that the polyclonal antibodies are specific for the polypeptide of the invention in question.
Monoclonal antibodies are produced by injecting mice with a peptide derived from a polypeptide of the invention, with or without adjuvant. Subsequently, the mouse is boosted every 2 weeks until an appropriate immune response has been identified (typically 1-6 months), at which point the spleen is removed. The spleen is minced to release splenocytes, which are fused (in the presence of polyethylene glycol) with murine myeloma cells. The resulting cells (hybridomas) are grown in culture and selected for antibody production by clonal selection. The antibodies are secreted into the culture supernatant, facilitating the screening process, such as screening by an enzyme-linked immunosorbent assay (ELISA). Alternatively, humanized monoclonal antibodies are produced either by engineering a chimeric murine/human monoclonal antibody in which the murine-specific antibody regions are replaced by the human counterparts and produced in mammalian cells, or by using transgenic “knock out” mice in which the native antibody genes have been replaced by human antibody genes and immunizing the transgenic mice as described above.
Example 11
Determination of mRNA Expression of the Polynucleotides of the Invention in Normal and Pre-Eclampic Placental Tissues
Relative gene expression, at the mRNA level, across multiple placental tissues was measured using a real-time PCR system. This system consisted of a GeneAmp 5700 Sequence Detection System (Applied Biosystems) and GeneAmp 5700 SDS software (Applied Biosystems). The reaction mixture consists of SYBR Green PCR MasterMix (Applied Biosystems), oligos specific to one gene, and DEPC treated water. 20 ng mRNA equivalent cDNA (synthesized using MMLV RT enzyme from Invitrogen) is added to each reaction mixture. The samples are run on the GeneAmp 5700 Sequencing Detection System with a 30 second extension time and are analyzed at a fluorescence threshold of 0.5. Each cDNA is also run against an appropriate Housekeeping Gene Control that is used for normalization.
The real-time PCR protocol was performed on both SEQ ID NO: 357 and 551. After this analysis was performed, the relative expression ratios of the two polynucleotides of the invention were determined across a selection of placental tissues. The raw cycle count scores for each gene in the measured tissues were selected, with each score representing the number of doublings required to detect the message. Next, the inverse expression ratios were computed for each gene in each measured tissue using the following formula:
- (2 raised to the power of the SEQ ID NO 347 raw cycle count score) divided by (2 raised to the power of the SEQ ID NO 551 raw cycle count score)
Finally, the computed ratios for each measured tissue were plotted on a log 10 scale as shown in FIG. 1 of the drawings. The following table relates the X-axis labels of FIG. 1 to the respective placental tissue source information.
TABLE 8
|
|
Label on X-axis
for FIG. 1Detailed Tissue Source Information
|
10.1. PE BP23 weeks of pregnancy, severe pre-eclampsia, basal-
plate region
1.1 PE BP23 weeks of pregnancy, severe pre-eclampsia, basal-
plate region
7.1 PE BP24 weeks of pregnancy, severe pre-eclampsia, basal-
plate region
4.1 PE BP29 weeks of pregnancy, severe pre-eclampsia, basal-
plate region
5.1 PE BP32 weeks of pregnancy, severe pre-eclampsia, basal-
plate region
11.1 PE BP38 weeks of pregnancy, pre-eclampsia, basal-plate
region
ECL00334 weeks of pregnancy, non-pre-eclamptic placenta,
NP BPbasal-plate region
9.1 NP BP39 weeks of pregnancy, non-pre-eclamptic placenta,
basal-plate region
8.1 NP BP40 weeks of pregnancy, non-pre-eclamptic placenta,
basal-plate region
6.3 NP BP41 weeks of pregnancy, non-pre-eclamptic placenta,
basal-plate region
13.1 NP BP39 weeks of pregnancy, elective Caesarian section,
non-pre-eclamptic placenta, basal-plate region
|
Example 12
Diagnostic Kit for Polypeptides of the Invention
A diagnostic kit can be made in order to determine the levels of selected polypeptides of the invention that are present in tissue samples obtained from a patient who is undergoing pregnancy. Such tissue samples may be from blood plasma, blood serum, amniotic fluid, or urine.
The components of the kit can be as follows: 1) one or more standards comprised of one or more polypeptides of the invention, prepared as described in example 9; 2) an antibody or a plurality of antibodies that are specific for the polypeptides of the invention that are being tested by the kit, prepared as described in example 10; 3) written instructions; 4) diluents for tissue samples and the standards; 5) a wash buffer; 6) color reagents; 7) stop solution; and 8) a microplate with bound antibody.
An example of such a kit is an ELISA (enzyme-linked immunosorbent assay) quantification that determines the concentration or concentrations of a polypeptide or polypeptides of the invention. The principle of the assay is to use the quantitative sandwich enzyme immunoassay technique where a Polyclonal antibody selective for binding a polypeptide of the invention is pre-coated onto a microplate into its wells. The standards and sample are then pipetted into the wells and any of the polypeptide of the invention that is present is bound to this immobilized Polyclonal antibody. Next, the wells are washed with washing buffer, and an enzyme-linked Polyclonal antibody that is specific for the polypeptide of the invention is added to the wells. Washing again is performed, then a substrate solution is added to the wells. Color subsequently develops in proportion to the amount of polypeptide of the invention that is bound in the first step. The color development is stopped using a stop solution, and the intensity of the color is measured by a microplate reader.
This results of this assay are used to determine one or more concentration levels of the polypeptides of the invention. The assay reaction is performed in the same tube or well, or may be in separte tubes or wells. The level or levels of polypeptides of the invention that are being determined by this assay can be used to diagnose those patients with pre-eclampsia.
Example 13
Diagnostic Chip for Polypeptides of the Invention in Tissue Samples
The levels of polypeptides of the invention in biological tissue samples can be determined through the use of ProteinChip technology (Wright Jr., et al. Expert Review of Molecular Diagnositcs 2002, Vol. 2 pp. 549-63 hereby incorporated herein by reference). This process includes the additon of a few microliters of tissue sample onto the ProteinChip surface, which has both chemical (e.g., anionic, catioinic, hydrophobic, hydrophilic, metal) and biochemical (antibody, receptor, DNA, enzyme probes attached to its surface. Subsequently, binding occurs between the polypeptides of the invention and their respective probes, and the chip is washed at least three times in order to elute unbound protein, lipids, salts, and other substances. Next, an energy-absorbent molecule (EAM) such as sinapinic acid is added to the chip, and the chip is placed into a ProteinChip Reader which measures the molecular mass of the bound polypeptides. Peaks are subsequently produced from the ProteinChip Reader that are used to quantify the amount of polypeptides of the invention in the tissue sample
Patent Application
20050255114
