Claims
- 1. A calcium phosphate cement composition, comprising:
an amorphous calcium phosphate having a calcium to phosphate molar ration of about 1.55 to 1.65; at least one additional calcium phosphate source; and a physiologically acceptable aqueous liquid.
- 2. The calcium phosphate cement composition of claim 1, wherein said at least one additional calcium source is a calcium source selected from the group consisting of calcium oxide, calcium hydroxide, calcium carbonate, and calcium phosphate.
- 3. The calcium phosphate cement composition of claim 2, wherein said calcium phosphate of said at least one additional calcium source is selected from the group consisting of tetracalcium phosphate, tricalcium phosphate and monocalcium phosophate monohydrate.
- 4. The calcium phosphate cement composition of claim 2, wherein said amorphous calcium phosphate is a solid.
- 5. The calcium phosphate cement composition of claim 2, wherein said amorphous calcium phosphate is a gel.
- 6. The calcium phosphate cement composition of claim 5, wherein said gel consists of said amorphous calcium phosphate and said physiologically acceptable liquid.
- 7. A calcium phosphate composition comprising:
a dry component comprising an amorphous calcium phosphate having a calcium to phosphate molar ration of about 1.55 to 1.65 and at least one additional calcium phosphate; and a physiologically acceptable aqueous lubricant.
- 8. The calcium phosphate composition of claim 7, wherein said at least one additional calcium phosphate is selected from the group consisting of tetracalcium phosphate, tricalcium phosphate and monocalcium phosphate monohydrate.
- 9. The calcium phosphate composition of claim 8, wherein said cement further comprises an organic polymer.
- 10. The calcium phosphate composition of claim 9, wherein said organic polymer is a protein.
- 11. A method for preparing a remodelable calcium phosphate mineral, said method comprising:
combining an amorphous calcium phosphate having a calcium to phosphate molar ratio of about 1.55 to 1.65; at least one additional calcium source; and a physiologically acceptable aqueous liquid to produce a flowable composition; and allowing said flowable composition to set into said calcium phosphate mineral.
- 12. The method of claim 11, wherein sad at least one additional calcium source is a calcium source selected from the group consisting of calcium oxide, calcium hydroxide, calcium carbonate, and calcium phosphate.
- 13. The method of claim 11, wherein said at least one additional calcium phosphate is selected from the group consisting of tetracalcium phosphate, tricalcium phosphate and monocalcium phosphate monohydrate.
- 14. The method of claim 12, wherein said calcium phosphate is an apatite.
- 15. The method of claim 14, wherein said apatite is hydroxyapatite.
- 16. The method of claim 15, wherein said hydroxyapatite is a calcium deficient calcium phosphate.
- 17. A method for preparing a remodelable hydroxyapatite, said method comprising:
combining an amorphous calcium phosphate having a calcium to phosphate molar ratio of about 1.55 to 1.65; at least one additional calcium phosphate source; and a physiologically acceptable aqueous liquid to produce a flowable composition; and allowing said flowable composition to set into said remodelable hydroxyapatite.
- 18. The method of claim 17, wherein said remodelable hydroxyapatite is calcium deficient hydroxyapatite.
- 19. The method of claim 17, wherein said at least one additional calcium phosphate is tetracalcium phosphate.
- 20. The method of claim 17, wherein said at least one additional calcium phosphate is tricalcium phosphate.
Parent Case Info
[0001] This application is a continuation-in-part application of co-pending application U.S. Ser. No. 08/650,764 filed May 20, 1996 entitled “Novel Bone Substitution Material and a Method of Its Manufacture”, which is a continuation-in-part application of co-pending application U.S. Ser. No. 08/446,182 filed May 19, 1995 entitled “Synthesis of Reactive Amorphous Calcium Phosphates”, both of which are herein incorporated in its entirety by reference. This application also is related to several co-pending applications filed on even day herewith, entitled, “Bioresorbable Ceramic Composites”, “Delivery Vehicle”, “Cell Seeding of Ceramic Compositions” and “Orthopedic and Dental Ceramic Implants”, each of which is incorporated by reference.
Continuations (2)
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08729344 |
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Continuation in Parts (2)
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08446182 |
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