Patent Application
20240139535
This application relates to magnetic systems for delivery of magnetic-nanoparticle formulations to desired targets in a patient, and more specifically, to systems and methods to better align magnetic forces with patient anatomy.
In various aspect, the present disclosure describes a method for configuring a medical cart, the method comprising: selecting a location of a headrest on the medical cart that is configured to support a patient in a first administration position and the second administration position; determining the location and position of a simulated patient, wherein the simulated patient is positioned in the first administration position and the second administration position; determining a plurality of target locations based on anatomy of the simulated patient; determining (X, Y, Z) coordinates of the plurality of target locations relative to an origin location at (0, 0, 0); selecting a position of the magnetic assembly, wherein the position is relative to the origin location, wherein the magnetic assembly comprises a plurality of magnetic elements, wherein each of the plurality of magnetic elements generates a magnetization that combines to produce a resulting magnetic field of the magnetic assembly; determining relative distance in space between the magnetic assembly and the plurality of target locations; selecting magnetic force directions relative to each of the plurality of target locations; determining a resulting magnetic field generated by the magnetic assembly such that the magnetic assembly generates the magnetic force directions relative to each of the plurality of target locations; determining a magnetization and direction for each of the plurality of magnetic elements; configuring the magnetic assembly where the plurality of magnetic elements are spatially located and directionally positioned such that the magnetic assembly produces magnetic force directions relative to each of the plurality of target locations.
The various aspects described herein, both as to organization and methods of operation, together with further objects and advantages thereof, may best be understood by reference to the following description, taken in conjunction with the accompanying drawings as follows.
The present disclosure describes a medical cart for treating medical conditions affecting the middle ears in patients, by using magnetic force to push the magnetic agent to a target position. In various aspects, a patient (e.g., a child or an adult) may lie or sit on the medical cart or bed and undergo a procedure of medical treatment with a magnetic agent. The magnetic agent comprises magnetic particles with attached therapies, such as drugs, proteins, or genes, and the magnetic agent is directed to the patient's middle ear or ears with magnetic forces, as disclosed in U.S. Patent Application Publication No. 2020/0146995, which is incorporated herein by reference in its entirety. In one aspect, the medical cart comprises a bed platform, a head rest, one or more guild rails, an alignment grid to guide alignment of the patient's head by a doctor or clinician, and other components to keep the patient comfortable (e.g. covering, cushions, etc). The medical cart further comprises a magnet assembly located beneath the bed platform, and is configured to pull magnetic particles into the middle ears of the patient. The magnetic array may be hidden by removable side coverings or fairings to provide a less intimidating appearance to the patient.
In various aspects, the medical cart is configured to treat one or both ears of the patient, and is optimized for the patient's conform during the treatment procedure. Additionally, the medical cart is designed for effective and easy use by the doctor or clinician, and can fit into a clinical setting (is safe and convenient to use, can be stowed away when not in use, etc.). In one aspect, the headrest comprises an alignment grid that guides a clinician to position the patient on the medical cart and aids in the administration of a magnetic therapeutic agent by the doctor or clinician. The shape of the headrest and the location of the alignment grids may be configured according to the location and proximity to the magnetic assembly, and in consideration of principles of physics (e.g. gravitational or magnetic force) and human anatomy constraints of the left and right ear, as shown in
These anatomical characteristics, illustrated by
In various aspects, both right and left ears may be treated in a single administration session. In order to treat both ears in a single session, it is necessary that once a first ear is treated, that treating the second ear does not reverse or partially reverse the treatment just completed for the first ear. For example, a patient's right ear 206 is treated first in the first treatment position 222, allowing the magnetic therapeutic agent to be pulled to the patient's right middle ear space. The patient's left ear may then be subsequently treated after the right ear. While treating the left ear 204 in the second treatment position 224, it is necessary that “stray” magnetic force does not pull the magnetic particles out of the right ear 206. The first 222 and second treatment positions 224 are specifically designed so that magnetic forces 240b and 240n keep the magnetic therapeutic agent in the previously treated ear. For example, when the patient is in the second treatment positon 224, the magnetic force 240n on the right ear 206′ is oriented substantially through the right ear drum, but the magnetic force 240c on the left ear 204 is also still oriented through the left ear drum and is not oriented in such a way as to pull particles back out of the left middle ear space.
It is further desirable that the medical cart is configured to naturally support the patient's head, so that the head is oriented according to the magnetic force produced by the magnetic assembly. Thus, the system discloses a predetermined headrest shapes that specifically positon the patient's head according to gravitational and magnetic forces, for the first and second ear administration. Further, a transparent alignment grid may be visible or engraved into the headrest to aid the clinician in quickly and accurately placing the patient's head in the administration position.
In various aspects, the shape of the headrest, the location of the first and second headrest contours, and the location of alignment grid are determined according to the relative position to the magnetic assembly and the forces produced by the magnetic assembly. Accordingly, the magnetic assembly is configured according to the location, size, shape, and magnetization of magnets, to produce a desired magnetic force (e.g. 1 tesla of force experienced at the ear canal of the administration ear) on the therapeutic agent in patient's ear canals. The magnetic force, which is not the same nor equal to the magnetic field, is configured to produce directional force (vectors) for the left and right ear, in the first administration position 222 and the second administration positon 224.
If the vector magnetic field is denoted by B, where
B=[Bx(x, y, z), By(x, y, z), Bz(x, y, z)] is a 3-dimensional vector that varies across space X=(x, y, z), then the force on magnetic nanoparticles is given by
B and is itself also a 3-dimensional vector that varies across space, i.e. F=[Fx(x, y, z), Fy,(x, y, z), Fz(x, y, z)]. Here,
is the Jacobian matrix, and k is a coefficient whose properties depend based on the size and material parameters of the magnetic1 nanoparticles. Alternatively and equivalently, the magnetic force F can also be written as
where grad is the gradient, ∥B∥ is the norm of B. We disclose that the selection of the magnet assembly was chosen so that the magnetic force F=[Fx(x, y, z), Fy (x, y, z), Fz(x, y, z)] points in the desired directions, meaning it matches the directions shown in
In one aspect, the headrest can be shaped as shown, and the magnet is under it inside the cart. The patient's natural head position may be set by the headrest, and can orient the ears so that the magnetic force points from ear canal through the ear drum into the middle ear. The medical cart is configured to treat one ear at a time, without “untreating” the previously treated ear with the magnet assembly.
In various aspects, the magnetic assembly 400 may comprise electromagnets, permanent magnets, or an array of permanent magnets.
In one aspect, the pillars 402 of the magnet assembly 400 may comprises a plurality of small disc magnets 408, such as Neodymium N42 disc magnets where each disc is 2 inches in diameter by 1 inch in height, with a ¼ inch hole in the middle for a supporting rod to go through. The plurality of disc magnets may be bonded together with a supporting rod 410, where each of the plurality of discs may be magnetized in the same vertical direction with opposite polarity ends attracted to each other. In one aspect, there may be 10 magnetic discs 408 for each pillar 402 in the array. In one aspect, the magnet assembly may be approximately 14 inches wide, +/−1 inch, 14 inches deep+/−1 inch, and 10 inches tall+/−1 inch.
The magnetic fields of the plurality of discs combine to create a resulting magnetic field for each pillar. Similarly, the magnetic fields of the plurality of pillars combine to create a resulting magnetic field for the magnetic assembly. Therefore, the same resulting magnetic fields may be produced by different magnetic assembly pillar and disc combinations. As discussed above, the resulting magnetic field is determined according to a calculated magnetic force on the magnetic nanoparticles.
The magnetic fields of the plurality of discs combine to create a resulting magnetic field for each pillar. Similarly, the magnetic fields of the plurality of pillars combine to create a resulting magnetic field for the magnetic assembly. Therefore, the same resulting magnetic fields may be produced by different magnetic assembly pillar and disc combinations. As discussed above, the resulting magnetic field is determined according to a calculated magnetic force on the magnetic nanoparticles.
The headrest 326 may also be removable and would require one or more headrest markings to affix or align the headrest so that the alignment grid correctly aligns with the magnet assembly beneath the upper bed platform 338. It is anticipated that the clinician would stand behind or to the side of the patient and help align the patient's head with the alignment grid 346 of the headrest 326. Additionally, the headrests 326 may be different sizes for different patient head diameters and may require alignment grids to be uniquely calibrated for the shape of the headrest. In one aspect, the shape and size of the first and second head contours of the headrest are different sizes to meeting smaller or larger patients. Accordingly, the alignment grid is calibrated so that the patient's head is in the desired position for the magnetic force to act upon the magnetic therapeutic agent.
The simulated patient's head orientation is determined according to the headrest position on the medical cart, alignment grid 346 on the headrest 526, and the patient's head position in the first administration position 522 and second administration position 524. Once the location and orientation of the simulated patient is known, various target locations relative to the patient's ear canal can be determined.
For example, when the patient is in the first administration position, it may be desirable to generate a pull force at the middle ear of the active administration ear to pull a therapeutic agent. Simultaneously, it may be desirable to generate a push force at the outside ear of the passive administration ear to offset the force of gravity and prevent a therapeutic agent from dipping out of a previously treated ear. In another example, a push force and pull force may be generated at along the same ear canal.
A plurality of target locations is determined based on the need for the therapeutic agent to reach the middle ear and to stay at the middle ear while treating the other ear. The specific location of target locations 550a-d are determined in three dimensional space based on (X,Y, Z) coordinates relative to the medical cart. In one aspect, the origin location 552, at coordinates (0, 0, 0), is on the medical at the midpoint of the headrest in the length and width direction. Target locations 550a-d are determined based on their relative locations to the origin 552.
The magnetic force and direction 540a-d is generated at each target locations 550a-d based on the configuration of the plurality of magnetic elements 560a-n that make up the magnetic assembly 536. In another aspect the plurality of magnetic elements 560a-n may be configured based on magnetic force and direction 540a-h. The plurality of magnetic elements 560a-n generates individual magnetic fields that combine to create a resulting magnetic field of the magnetic assembly 536. In various aspects, the quadratic mapping may be used to determine a magnetic assembly configuration.
In one aspect, the quadratic mapping is m′ Qkm, where m is a vector that represents the to-be-selected magnetization at each magnetic elements 560a-n of the magnetic assembly 536. Where, m=[m1x,m1y,m1z; m2x,m2y,m2z; . . . , mNx,mNy,mNz], and the triplet (mjx, mjy, mjz) is the x, y, z magnetization of the jth component. By selecting different (mjx, mjy, mjz), the magnetization can be selected in any direction for that jth component, where jth component is one magnetic elements 560a-n in the magnetic assembly 536. The matrix, Qk, encapsulates the resulting direction of the magnetic force on an agent at location Rk=(Xk, Yk, Zk). In various aspects, Rk is a target location, such as the location of the center of the right ear drum when the right ear is being treated, or target locations 550a-d in
Overall, there is a complex proportional relationship between the magnetization directions m generated by the magnetic assembly 536 and the force directions, v=[v1, v2, . . . , vK], exerted at the target locations R=[R1, R2, . . . , Rk]. The quadratic mapping equations, shown above, may be used to select a magnetization, m, to achieve a force directions, v, to approach the desired directions d=[d1, d2, . . . , dK] as closely as possible. The purpose of configuring the magnetic elements 560a-n of the magnetic assembly 536 is to create a magnetic system that orients forces in space to match the simulated patient anatomy, as illustrated in
In various aspects, the magnetic assembly may generate push nodes, pull nodes, or complex directional forces are neither “pushing” nor “pulling” based on the arrangement and position of the magnetic elements in the magnetic assembly. In one example, forces may be arranged in the desired directions based on the target locations. Additionally, a directional force may be substantially oriented at an angle through the patient's ear drum (tympanic membrane).
Various additional aspects of the subject matter described herein are set out in the following numbered examples:
Example 1: A method for configuring a medical cart, the method comprising:
Example 2: The method of Example 1, wherein determining the plurality of target locations is further comprising: determining a first target locations relative to the simulated patient in the first administration position, wherein the first target location is based on ear canal anatomy of a first ear of the simulated patient in an active administration ear; determining a second target locations relative to the simulated patient in the first administration position, wherein the second target location is based on ear canal anatomy of a second ear of the simulated patient in a passive administration ear; determining a third target locations relative to the simulated patient in the second administration position, wherein the third target location is based on ear canal anatomy of the second ear of the simulated patient in the active administration ear; and determining a fourth target locations relative to the simulated patient in the second administration position, wherein the fourth target location is based on ear canal anatomy of the first ear of the simulated patient in the passive administration ear.
Example 3: The method of Example 2, wherein the magnetization of each of the plurality of magnetic elements is the maximum magnetic saturation based on the composition material of the plurality of magnetic elements.
Example 4: The method of Examples 3, wherein the material composition of the plurality of magnets is same material composition for all of the plurality of magnets.
Example 5: The method of Examples 1-4, wherein each magnetic elements of the plurality of magnetic elements are selectively positioned and placed at (X, Y, Z) coordinate locations relative to the origin location, within the magnetic assembly.
Example 6: The method of claim 2-5, wherein the resulting magnetic field creates directional forces at a desired angle or angles based on the plurality of target locations.
Example 7: The method of claim 6, wherein the desired angle or angles comprise orientation angles through ear drums of the patient.
Example 8: The method of Examples 2-5, wherein the resulting magnetic field creates a pushing force in the direction of the middle ear at the plurality of target locations.
Example 9: The method of Examples 2-5, wherein the resulting magnetic field creates a pushing force in the direction of the ear canal at the first and the third target location, and a pulling force in the direction of the ear canal at the second and the four target location, wherein the direction of the pushing force and pulling force is from the outside inward along the ear canal.
Example 10: The method of Examples 2-9, wherein the resulting magnetic field creates a pulling force in the direction of the ear canal at the first and the third target location, and a push node direction of the ear canal at the second and the four target location, wherein the direction of the pushing force and pulling force is from the outside inward along the ear canal.
Example 11: The method of Example 1-10, wherein determining each of the plurality of target locations is based the alignment of simulated patient with a vertical position indicator and a horizontal position indicator on an alignment grid of the headrest.
Example 12: The method of Example 2-11, the first target location and the second target location is the middle ear of the first ear, and the third target location and the fourth target location is the middle ear of the second ear.
Example 13: The method of Examples 1-12, wherein the first target location is the middle ear of the first ear and the third target location is the middle ear of the first ear.
Example 14: The method of Examples 1-13, the second target location is the outer ear of the first ear and the forth target location is the outer ear of the second ear.
Example 15: The method of Examples 1-14, wherein the ear canal anatomy of the simulated patient is modeled on a predetermined age range and development of the patient.
Example 16: The method of Examples 1-15, wherein the simulated patient age range and development is a median head size and median ear canal of a child between the ages of 3-7 years old.
Example 17: The method of Examples 1-16, wherein the magnetization and direction for each of the plurality of magnetic elements is determined according mj=(mjx, mjy, mjz), where m is the magnetization and j is the jth magnetic element in the magnetic assembly.
While several forms have been illustrated and described, it is not the intention of Applicant to restrict or limit the scope of the appended claims to such detail. Numerous modifications, variations, changes, substitutions, combinations, and equivalents to those forms may be implemented and will occur to those skilled in the art without departing from the scope of the present disclosure. Moreover, the structure of each element associated with the described forms can be alternatively described as a means for providing the function performed by the element. Also, where materials are disclosed for certain components, other materials may be used. It is therefore to be understood that the foregoing description and the appended claims are intended to cover all such modifications, combinations, and variations as falling within the scope of the disclosed forms. The appended claims are intended to cover all such modifications, variations, changes, substitutions, modifications, and equivalents.
The foregoing detailed description has set forth various forms of the devices and/or processes via the use of block diagrams, flowcharts, and/or examples. Insofar as such block diagrams, flowcharts, and/or examples contain one or more functions and/or operations, it will be understood by those within the art that each function and/or operation within such block diagrams, flowcharts, and/or examples can be implemented, individually and/or collectively, by a wide range of hardware, software, firmware, or virtually any combination thereof. Those skilled in the art will recognize that some aspects of the forms disclosed herein, in whole or in part, can be equivalently implemented in integrated circuits, as one or more computer programs running on one or more computers (e.g., as one or more programs running on one or more computer systems), as one or more programs running on one or more processors (e.g., as one or more programs running on one or more microprocessors), as firmware, or as virtually any combination thereof, and that designing the circuitry and/or writing the code for the software and or firmware would be well within the skill of one of skill in the art in light of this disclosure. In addition, those skilled in the art will appreciate that the mechanisms of the subject matter described herein are capable of being distributed as one or more program products in a variety of forms, and that an illustrative form of the subject matter described herein applies regardless of the particular type of signal bearing medium used to actually carry out the distribution.
Instructions used to program logic to perform various disclosed aspects can be stored within a memory in the system, such as dynamic random access memory (DRAM), cache, flash memory, or other storage. Furthermore, the instructions can be distributed via a network or by way of other computer readable media. Thus a machine-readable medium may include any mechanism for storing or transmitting information in a form readable by a machine (e.g., a computer), but is not limited to, floppy diskettes, optical disks, compact disc, read-only memory (CD-ROMs), and magneto-optical disks, read-only memory (ROMs), random access memory (RAM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), magnetic or optical cards, flash memory, or a tangible, machine-readable storage used in the transmission of information over the Internet via electrical, optical, acoustical or other forms of propagated signals (e.g., carrier waves, infrared signals, digital signals, etc.). Accordingly, the non-transitory computer-readable medium includes any type of tangible machine-readable medium suitable for storing or transmitting electronic instructions or information in a form readable by a machine (e.g., a computer).
As used in any aspect herein, the term “control circuit” may refer to, for example, hardwired circuitry, programmable circuitry (e.g., a computer processor including one or more individual instruction processing cores, processing unit, processor, microcontroller, microcontroller unit, controller, digital signal processor (DSP), programmable logic device (PLD), programmable logic array (PLA), or field programmable gate array (FPGA)), state machine circuitry, firmware that stores instructions executed by programmable circuitry, and any combination thereof. The control circuit may, collectively or individually, be embodied as circuitry that forms part of a larger system, for example, an integrated circuit (IC), an application-specific integrated circuit (ASIC), a system on-chip (SoC), desktop computers, laptop computers, tablet computers, servers, smart phones, etc. Accordingly, as used herein “control circuit” includes, but is not limited to, electrical circuitry having at least one discrete electrical circuit, electrical circuitry having at least one integrated circuit, electrical circuitry having at least one application specific integrated circuit, electrical circuitry forming a general purpose computing device configured by a computer program (e.g., a general purpose computer configured by a computer program which at least partially carries out processes and/or devices described herein, or a microprocessor configured by a computer program which at least partially carries out processes and/or devices described herein), electrical circuitry forming a memory device (e.g., forms of random access memory), and/or electrical circuitry forming a communications device (e.g., a modem, communications switch, or optical-electrical equipment). Those having skill in the art will recognize that the subject matter described herein may be implemented in an analog or digital fashion or some combination thereof.
As used in any aspect herein, the term “logic” may refer to an app, software, firmware and/or circuitry configured to perform any of the aforementioned operations. Software may be embodied as a software package, code, instructions, instruction sets and/or data recorded on non-transitory computer readable storage medium. Firmware may be embodied as code, instructions or instruction sets and/or data that are hard-coded (e.g., nonvolatile) in memory devices.
As used in any aspect herein, the terms “component,” “system,” “module” and the like can refer to a control circuit computer-related entity, either hardware, a combination of hardware and software, software, or software in execution.
As used in any aspect herein, an “algorithm” refers to a self-consistent sequence of steps leading to a desired result, where a “step” refers to a manipulation of physical quantities and/or logic states which may, though need not necessarily, take the form of electrical or magnetic signals capable of being stored, transferred, combined, compared, and otherwise manipulated. It is common usage to refer to these signals as bits, values, elements, symbols, characters, terms, numbers, or the like. These and similar terms may be associated with the appropriate physical quantities and are merely convenient labels applied to these quantities and/or states.
A network may include a packet switched network. The communication devices may be capable of communicating with each other using a selected packet switched network communications protocol. One example communications protocol may include an Ethernet communications protocol which may be capable permitting communication using a Transmission Control Protocol/Internet Protocol (TCP/IP). The Ethernet protocol may comply or be compatible with the Ethernet standard published by the Institute of Electrical and Electronics Engineers (IEEE) titled “IEEE 802.3 Standard”, published in December, 2008 and/or later versions of this standard. Alternatively or additionally, the communication devices may be capable of communicating with each other using an X.25 communications protocol. The X.25 communications protocol may comply or be compatible with a standard promulgated by the International Telecommunication Union-Telecommunication Standardization Sector (ITU-T). Alternatively or additionally, the communication devices may be capable of communicating with each other using a frame relay communications protocol. The frame relay communications protocol may comply or be compatible with a standard promulgated by Consultative Committee for International Telegraph and Telephone (CCITT) and/or the American National Standards Institute (ANSI). Alternatively or additionally, the transceivers may be capable of communicating with each other using an Asynchronous Transfer Mode (ATM) communications protocol. The ATM communications protocol may comply or be compatible with an ATM standard published by the ATM Forum titled “ATM-MPLS Network Interworking 2.0” published August 2001, and/or later versions of this standard. Of course, different and/or after-developed connection-oriented network communication protocols are equally contemplated herein.
Unless specifically stated otherwise as apparent from the foregoing disclosure, it is appreciated that, throughout the foregoing disclosure, discussions using terms such as “processing,” “computing,” “calculating,” “determining,” “displaying,” or the like, refer to the action and processes of a computer system, or similar electronic computing device, that manipulates and transforms data represented as physical (electronic) quantities within the computer system's registers and memories into other data similarly represented as physical quantities within the computer system memories or registers or other such information storage, transmission or display devices.
One or more components may be referred to herein as “configured to,” “configurable to,” “operable/operative to,” “adapted/adaptable,” “able to,” “conformable/conformed to,” etc. Those skilled in the art will recognize that “configured to” can generally encompass active-state components and/or inactive-state components and/or standby-state components, unless context requires otherwise.
The terms “proximal” and “distal” are used herein with reference to a clinician manipulating the handle portion of the surgical instrument. The term “proximal” refers to the portion closest to the clinician and the term “distal” refers to the portion located away from the clinician. It will be further appreciated that, for convenience and clarity, spatial terms such as “vertical”, “horizontal”, “up”, and “down” may be used herein with respect to the drawings. However, surgical instruments are used in many orientations and positions, and these terms are not intended to be limiting and/or absolute.
Those skilled in the art will recognize that, in general, terms used herein, and especially in the appended claims (e.g., bodies of the appended claims) are generally intended as “open” terms (e.g., the term “including” should be interpreted as “including but not limited to,” the term “having” should be interpreted as “having at least,” the term “includes” should be interpreted as “includes but is not limited to,” etc.). It will be further understood by those within the art that if a specific number of an introduced claim recitation is intended, such an intent will be explicitly recited in the claim, and in the absence of such recitation no such intent is present. For example, as an aid to understanding, the following appended claims may contain usage of the introductory phrases “at least one” and “one or more” to introduce claim recitations. However, the use of such phrases should not be construed to imply that the introduction of a claim recitation by the indefinite articles “a” or “an” limits any particular claim containing such introduced claim recitation to claims containing only one such recitation, even when the same claim includes the introductory phrases “one or more” or “at least one” and indefinite articles such as “a” or “an” (e.g., “a” and/or “an” should typically be interpreted to mean “at least one” or “one or more”); the same holds true for the use of definite articles used to introduce claim recitations.
In addition, even if a specific number of an introduced claim recitation is explicitly recited, those skilled in the art will recognize that such recitation should typically be interpreted to mean at least the recited number (e.g., the bare recitation of “two recitations,” without other modifiers, typically means at least two recitations, or two or more recitations). Furthermore, in those instances where a convention analogous to “at least one of A, B, and C, etc.” is used, in general such a construction is intended in the sense one having skill in the art would understand the convention (e.g., “a system having at least one of A, B, and C” would include but not be limited to systems that have A alone, B alone, C alone, A and B together, A and C together, B and C together, and/or A, B, and C together, etc.). In those instances where a convention analogous to “at least one of A, B, or C, etc.” is used, in general such a construction is intended in the sense one having skill in the art would understand the convention (e.g., “a system having at least one of A, B, or C” would include but not be limited to systems that have A alone, B alone, C alone, A and B together, A and C together, B and C together, and/or A, B, and C together, etc.). It will be further understood by those within the art that typically a disjunctive word and/or phrase presenting two or more alternative terms, whether in the description, claims, or drawings, should be understood to contemplate the possibilities of including one of the terms, either of the terms, or both terms unless context dictates otherwise. For example, the phrase “A or B” will be typically understood to include the possibilities of “A” or “B” or “A and B.”
With respect to the appended claims, those skilled in the art will appreciate that recited operations therein may generally be performed in any order. Also, although various operational flow diagrams are presented in a sequence(s), it should be understood that the various operations may be performed in other orders than those which are illustrated, or may be performed concurrently. Examples of such alternate orderings may include overlapping, interleaved, interrupted, reordered, incremental, preparatory, supplemental, simultaneous, reverse, or other variant orderings, unless context dictates otherwise. Furthermore, terms like “responsive to,” “related to,” or other past-tense adjectives are generally not intended to exclude such variants, unless context dictates otherwise.
It is worthy to note that any reference to “one aspect,” “an aspect,” “an exemplification,” “one exemplification,” and the like means that a particular feature, structure, or characteristic described in connection with the aspect is included in at least one aspect. Thus, appearances of the phrases “in one aspect,” “in an aspect,” “in an exemplification,” and “in one exemplification” in various places throughout the specification are not necessarily all referring to the same aspect. Furthermore, the particular features, structures or characteristics may be combined in any suitable manner in one or more aspects.
Any patent application, patent, non-patent publication, or other disclosure material referred to in this specification and/or listed in any Application Data Sheet is incorporated by reference herein, to the extent that the incorporated materials is not inconsistent herewith. As such, and to the extent necessary, the disclosure as explicitly set forth herein supersedes any conflicting material incorporated herein by reference. Any material, or portion thereof, that is said to be incorporated by reference herein, but which conflicts with existing definitions, statements, or other disclosure material set forth herein will only be incorporated to the extent that no conflict arises between that incorporated material and the existing disclosure material.
In summary, numerous benefits have been described which result from employing the concepts described herein. The foregoing description of the one or more forms has been presented for purposes of illustration and description. It is not intended to be exhaustive or limiting to the precise form disclosed. Modifications or variations are possible in light of the above teachings. The one or more forms were chosen and described in order to illustrate principles and practical application to thereby enable one of ordinary skill in the art to utilize the various forms and with various modifications as are suited to the particular use contemplated. It is intended that the claims submitted herewith define the overall scope.
This application claims the benefit under 35 U.S.C. § 119(e) to U.S. Provisional Patent Application No. 63/184,072, titled METHODS AND SYSTEMS FOR SHAPING MAGNETICS FIELDS TO ALIGN FORCES ON MAGNETIC PARTICLES FOR PATIENT ANATOMY AND MOTION, filed May 4, 2021, the disclosure of each of which is herein incorporated by reference in its entirety.
| Number | Date | Country | |
|---|---|---|---|
| 63184072 | May 2021 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | PCT/US2022/072080 | May 2022 | US |
| Child | 18386765 | US |
