Claims
- 1. A composition for preventing or minimizing ammonia odor produced by the degradation of urea in secreted or excreted body fluids and residues thereof, said composition comprising:
(a) an effective amount of a urease inhibitor, said inhibitor comprising a complex formed from a polyanionic chelating agent and a divalent metal ion, wherein said metal ion is complexed at from 4 to 6 coordination sites, wherein one additional coordination site of said metal ion remains available for binding with urease, and wherein said complex has a stability constant K such that log (10) K is greater than 12.5; and, (b) an an effective amount of an agent suitable for delivering said urease inhibitor complex into contact with said secreted or excreted body fluids and residues thereof.
- 2. The composition of claim 1, wherein said chelating agent comprises an amine-based chelating agent and said delivery agent comprises a liquid carrier or a solid carrier.
- 3. The composition of claim 2, wherein said composition is in the form of an aqueous solution containing from 0.1% by weight to 10% by weight of said urease inhibitor complex.
- 4. The composition of claim 2, wherein said urease inhibitor complex is chemically modified to render said complex substantive to a substrate upon contact of said substrate with said composition.
- 5. The composition of claim 2, wherein said divalent metal ion is selected from the group consisting of copper, iron, zinc, cobalt, nickel, and combinations thereof.
- 6. The composition of claim 5, wherein said chelating agent is selected from the group consisting of nitrilotriacetic acid, iminodisuccinic acid, substituted ethylenediamine materials, and combinations thereof, and wherein said substituted ethylenediamine materials have the general formula:
- 7. The composition of claim 1, wherein said urease inhibitor further comprises a pentadentate chelant complex, said pentadentate chelant complex being formed by chelating copper with a compound selected from the group of consisting of N-hydroxyethyl-ethylene-diamine-triacetic acid, iminodisuccinic acid, and combinations thereof.
- 8. An article for preventing or minimizing ammonia odor produced by a degradation of urea in secreted or excreted body fluids and residues thereof, said article comprising:
(a) an effective amount of a urease inhibitor, said inhibitor comprising a complex formed from a polyanionic chelating agent and a divalent metal ion wherein said metal ion is complexed at from 4 to 6 coordination sites, wherein additional coordination site of said metal ion remains available for binding with urease, and wherein said complex has a stability constant K such that log(10)K is greater than 12.5; and, (b) means for delivering said urease inhibitor complex into contact with said urea in said secreted or excreted body fluids and residues thereof.
- 9. The article of claim 8, wherein said chelating agent comprises an amine-based chelating agent and wherein said article comprises a wearable absorbent article for discharged body fluids, said wearable absorbent article further comprising an absorbent core disposed between a fluid impervious backsheet and a fluid pervious topsheet.
- 10. The article of claim 9, wherein said delivery means comprises providing said urease inhibitor complex in operative association with one of said absorbent core, said fluid impervious backsheet, or said fluid pervious topsheet, and wherein said article further comprises from 0.1 mg to 100 mg of said urease inhibitor per gram of said article.
- 11. The article of claim 8, wherein said chelating agent comprises an amine-based chelating agent; wherein said article is selected from the group consisting of sweatbands, socks, underwear, bed sheets, mattress covers, pillow cases, hand or bath towels, underarm pads, surgical gowns or drapes, wiping cloths, carpets, brushes, mops or paper towels, and combinations thereof; and wherein said urease inhibitor complex comprises from 0.1% by weight to 10% by weight of said article.
- 12. The article of claim 8, wherein said divalent metal ion is selected from the group consisting of copper, iron, zinc, cobalt, nickel, and combinations thereof.
- 13. The article of claim 12, wherein said chelating agent is selected from the group consisting of nitrilotriacetic acid, iminodisuccinic acid, substituted ethylenediamine materials, and combinations thereof, and wherein said substituted ethylenediamine materials have the general formula:
- 14. The article of claim 8, wherein said urease inhibitor comprises a pentadentate chelant complex, said pentadentate chelant complex being formed by chelating copper with a compound selected from the group consisting of N-hydroxyethyl-ethylene-diamine-triacetic acid, iminodisuccinic acid, and combinations thereof.
- 15. A method for preventing or minimizing ammonia odor produced by degradation of urea in secreted or excreted body fluids and residues thereof, said method comprising:
(a) contacting an effective amount of a urease inhibitor with said urea in said secreted or excreted body fluids, and residues thereof,
wherein said urease inhibitor comprises a complex formed from a polyanionic chelating agent and a divalent metal ion; wherein said metal ion is complexed at from 4 to 6 coordination sites; wherein one additional coordination site of said metal ion remains available for binding with urease; and, wherein said complex has a stability constant K such that log (10) K is greater than 12.5.
- 16. The method of claim 15, wherein said contacting step further comprises contacting at least one substrate insulted with said body fluids with a composition containing said urease inhibitor complex, and wherein said chelating agent is an amine-based chelating agent.
- 17. The method of claim 16, wherein said at least one substrate comprises a hard surface and said urease inhibitor complex contacts said hard surface as a composition in liquid form.
- 18. The method of claim 15, wherein said divalent metal ion is selected from the group consisting of copper, iron, zinc, cobalt, nickel, and combinations thereof.
- 19. The method of claim 18, wherein said chelating agent is selected from the group consisting of nitrilotriacetic acid, iminodisuccinic acid, substituted ethylenediamine materials, and combinations thereof, and wherein said substituted ethylenediamine materials have the general formula:
- 20. The method of claim 15, wherein said urease inhibitor comprises a pentadentate chelant complex, said pentadentate chelant complex being formed by chelating copper with a compound selected from the group consisting of N-hydroxyethyl-ethylenediamine-triacetic acid, iminodisuccinic acid, and combinations thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
00870301.9 |
Dec 2000 |
EP |
|
CROSS-REFERENCE TO PRIOR APPLICATION
[0001] This is a continuation of International Application US01/48942, with an international filing date of Dec. 13, 2001, and published in English.
Continuations (1)
|
Number |
Date |
Country |
Parent |
PCT/US01/48942 |
Dec 2001 |
US |
Child |
10459866 |
Jun 2003 |
US |