Methods for designing specific inhibitors for Pin1 proline isomerase and Pin1-related molecules

Abstract

This invention relates to methods for designing specific inhbitors of Pin1/parvulin family of peptidyl-prolyl cis-trans isomerases, particularly Pin1 and Pin1-related proteins, through the use of the structure coordinates and atomic details elucidated from the crystal structures of a mutant of Pin1, R14A, and co-complexes of R14A with various inhibitors. The invention further relates to inhibitors of Pin1 and Pin1-related proteins that are useful for therapeutic treatement of various disorders, and methods of using Pin1 inhibitors in pharmaceutical compositions. The invention further relates to the crystal structures of Pin1R14A alone, and of Pin1R14A in co-complex with molecules that bind to Pin1.

Description

TECHNICAL FIELD OF THE INVENTION

[0002] This invention relates to methods for designing specific inhibitors of Pin1/parvulin family of peptidyl-prolyl cis-trans isomerases, particularly Pin1 and Pin1-related proteins, through the use of the structure coordinates and atomic details elucidated from the crystal structures of a mutant of Pin1, R14A, and co-complexes of R14A with various inhibitors. The invention further relates to the crystal structures of Pin1R14A alone, and of Pin1R14A in co-complexes with various inhibitors.

BACKGROUND OF THE INVENTION

[0003] The peptidyl-prolyl cis-trans isomerases (PPIases), or rotamases, are a family of ubiquitous enzymes that catalyze the cis/trans isomerization of the peptide bond on the n-terminal side of proline residues in proteins (Hunter, Cell 92:141-142, 1998). PPIases are divided into three classes, cyclophilins (Cyps), FK-506 binding proteins (FKBPs) and the Pin1/parvulin class.

[0004] Cyclophilins and FKBPs are distinguished by their ability to bind the clinically immunosuppressive drugs cyclosporin and FK506, respectively (Schreiber, Science 251:283-7, 1991; Hunter, supra). Upon binding of these drugs, there are two common outcomes: inhibition of the PPIase activity and inhibition of the common target calcineurin. The inhibition of calcineurin phosphatase activity prevents lymphocytes from responding to antigen-induced mitogenic signals, thus resulting in immunosuppression. However, the inhibition of the PPIase activity is apparently unrelated to the immunosuppressive property of the drug/PPIase complexes. Even more surprisingly, deletion of all 8 known cyclophilins and 4 FKBPs in the same cells does not result in any significant phenotype (Dolinski et al., Proc. Natl. Acad. Sci. USA 94:13093-131098, 1997).

[0005] In contrast, members of the Pin1/parvulin class of PPIases bind neither of these immunosuppressive drugs, and are structurally unrelated to the other two classes of PPIases. Known members of the Pin1/parvulin class include Pins1-3 (Lu et al., Nature 380;544-547, 1996), Pin-L (Campbell et al., Genomics 44:157-162, 1997), parvulin (Rahfeld, et al., Proc. Natl. Acad. Sci. USA 93:447-451, 1996) and Ess1/Pft1 (Hanes et al., Yeast 5:55-72, 1989; and Hani, et al. FEBS Letts 365:198-202, 1995).

[0006] Pin1 is a highly conserved protein that catalyzes the isomerization of only phosphorylated Ser/Thr-Pro bonds (Rananathan, R. et al. (1997) Cell 89:875-86; Yaffe, et al. 1997, Science 278:1957-1960; Shen, et al. 1998, Genes Dev. 12:706-720; Lu, et al. 1999, Science 283:1325-1328; Crenshaw, et al. 1998, Embo J. 17:1315-1327; Lu, et al. 1999, Nature 399:784-788; Zhou, et al. 1999, Cell Mol. Life Sci. 56:788-806). In addition, Pin1 contains an N-terminal WW domain, which functions as a phosphorylated Ser/Thr-Pro binding module (Sudol, M. (1996) Prog. Biophys. Mol. Biol. 65:113-32). This phosphorylation-dependent interaction targets Pin1 to a subset of phosphorylated substrates, including Cdc25, Wee 1, Mytl, Tau-Rad4, and the C-terminal domain of RNA polymerase II large domain (Crenshaw, D. G., et al. (1998) Embo. J 17:1315-27; Shen, M. (1998) Genes Dev. 12:706-20; Wells, N. J. (1999) J. Cell. Sci. 112: 3861-71).

[0007] The specificity of Pin1 activity is essential for cell growth; depletion or mutations of Pin1 cause growth arrest, affect cell cycle checkpoints and induce premature mitotic entry, mitotic arrest and apoptosis in human tumor cells, yeast or Xenopus extracts (Lu, et al. 1996, Nature 380:544-547; Winkler, et al. 200, Science 287:1644-1647; Hani, et al. 1999. J. Biol. Chem. 274:108-116). In addition, Pin1 is dramatically overexpressed in human cancer samples and the levels of Pin1 are correlated with the aggressiveness of tumors. Moreover, inhibition of Pin1 by various approaches, including Pin1 antisense polynucleotides or genetic depletion, kills human and yeast dividing cells by inducing premature mitotic entry and apoptosis.

[0008] Thus, Pin 1-catalyzed prolyl isomerization regulates the conformation and function of these phosphoprotein substrates and facilitates dephosphorylation because of the conformational specificity of some phosphatases. Thus, Pin1-dependent peptide bond isomerization is a critical post-phosphorylation regulatory mechanism, allowing cells to turn phosphoprotein function on or off with high efficiency and specificity during temporally regulated events, including the cell cycle (Lu et al., supra).

[0009] Taken together, these results indicate that the Pin-1 subfamily of enzymes is a novel target for diseases characterized by uncontrolled cell proliferation, primarily malignancies. Therefore, there is an ongoing need for specific inhibitors of Pin1 and Pin1-related proteins, and for reliable methods of designing such inhibitors.

SUMMARY OF THE INVENTION

[0010] The present invention provides a method for designing specific inhibitors of Pin1 proline isomerase. The method is based, at least in part, on the identification of specific interactions within the proline isomerase active site between non-specific inhibitors, substrate-based peptides, and solvent-based molecules to define an interaction template. This may be achieved through the crystallographic screening of low affinity nonspecific inhibitors found in publicly available libraries. This method has allowed for the identification of functional regions of the active site (FIG. 2).

[0011] Exemplary compounds used in the methods of the invention are presented in FIG. 3.

[0012] The conserved and nonconserved regions of the Pin1 proline isomerases are identified through structural and sequence alignment analysis and used to generate a specificity template. Once this information is provided, inhibitors of increased affinity and specificity are designed to interact with the defined templates. The conformation of the improved inhibition and specificity are confirmed through biochemical assays.

[0013] In one aspect, the invention pertains, at least in part, to a Pin1 polypeptide in the crystallized form having a substitution, insertion or deletion of one or more amino acids of the amino acid sequence set forth in SEQ ID NO:1, wherein the active site of the Pin1 polypeptide in the crystallized form is accessible to solvent and available for interaction with an inhibitor.

[0014] In a related embodiment, the substitution, insertion or deletion of one or more amino acids is within the WW-domain of the Pin1 polypeptide.

[0015] In more specific embodiments, the crystallized Pin1 polypeptide has an amino acid substitution at position 14 of the amino acid sequence set forth in SEQ ID NO:1. And in one particular embodiment, the substitution at position 14 is a nonpolar amino acid. In a more particular embodiment, this nonpolar amino acid is an alanine (SEQ ID NO:2).

[0016] In one embodiment of the invention, the Pin1 polypeptide having a substitution, insertion or deletion crystallizes in less than 7 days, less than 3 days, less than 2 days or preferably less than one day.

[0017] In another related embodiment, the Pin1 polypeptide having a substitution, insertion or deletion crystallizes such that the resolution of the determined X-ray crystallography structure is 3 Å or less or preferably 2 Å or less.

[0018] In one particular embodiment, the crystal comprising the Pin1 polypeptide having a substitution, insertion, or deletion has the space group P3121.

[0019] In one related embodiment, the Pin1 polypeptide having a substitution, insertion or deletion is a fragment of the Pin1 polypeptide.

[0020] In another related embodiment, the crystal comprising the Pin1 polypeptide having a substitution, insertion, or deletion can also contain a small molecule, or an inhibitor in the active site.

[0021] In another aspect the invention pertains to a method for designing or selecting an inhibitor of a Pin1 polypeptide. This method includes using a three dimensional structure of a crystallized Pin1 polypeptide having a substitution, deletion or insertion of one or more amino acids to form a Pin1 interaction template and using the Pin1 interaction template to design or select the Pin1 inhibitor.

[0022] In another related embodiment, the crystal comprising the Pin1 polypeptide having a substitution, insertion, or deletion can also contain a small molecule, or an inhibitor.

[0023] In a related embodiment, the three dimensional structure of more than one crystallized Pin1 polypeptide is used to form the interaction template.

[0024] In a related embodiment, the three dimensional structure of more than one crystallized Pin1 polypeptide with a small molecule within the active site of the polypeptide is used to form the Pin1 interaction template.

[0025] In another embodiment the method of designing or selecting an inhibitor uses the interaction template in conjunction with a specificity template.

[0026] In another embodiment, the method of designing or selecting an inhibitor involves contacting the inhibitor with a Pin1 polypeptide and a Pin1 substrate to determine the ability of the inhibitor to inhibit the Pin1 polypeptide.

[0027] In a related embodiment the method of designing or selecting an inhibitor involves determining the affinity and specificity of the inhibitor.

[0028] In another embodiment, the invention pertains to a method of designing inhibitors with the following steps:

[0029] (a) determining the three-dimensional structures of crystallized Pin1 polypeptides in complex with small molecules;

[0030] (b) employing the three-dimensional structures from step (a) to form an interaction template;

[0031] (c) employing sequence and structural alignments to identify conserved amino acids among proline isomerases and distinguishing those amino acids that are specific to Pin1 to define a specificity template;

[0032] (d) using the interaction template and the specificity template in conjunction with molecular modeling to design or select inhibitors specific to Pin1 or Pin 1-like proline isomerases; and

[0033] (e) determining the affinity and specificity of the inhibitors to Pin1.

[0034] In a one embodiment, the invention pertains to methods of using the three dimensional structures to design or select chemical entities or fragments that bind to at least one of the following portions of the Pin1 active site: the hydrophobic pocket, the cysteine/serine valley, the phosphate binding pocket, the substrate-entry groove, and the lip regions.

[0035] In a related embodiment the chemical entities or fragments that bind to the active site are covalently linked.

[0036] The interaction template of the present invention can be used to identify, select, and or design Pin1 modulators (e.g., inhibitors) having any one or more of the following moieties:

[0037] A-B-C-D-E

[0038] where A is a hydrophobic pocket interacting moiety; where B is a cysteine/serine valley interacting moiety; where C is a phosphate pocket interacting moiety; where D is a substrate-entry groove interacting moiety; and where E is a lip region interacting moiety.

[0039] In related embodiments, the modulators (e.g., inhibitors) of the invention can contain any one, two, three, four or five of the interacting moieties. In specific embodiments the moieties can be small molecules, solvent based molecules, peptides, or peptide mimetics. In related embodiments the moieties fo the invention can be covalently linked. For example, a peptide that binds in the regions defined as A and B can be covalently linked to a small molecule that binds to C. In at least one embodiment, the compounds of this invention do not include fredericamycin A, or compounds related to fredericaniycin A.

[0040] In another embodimet the invention pertains to a method for designing an inhibitor of a second peptidyl/prolyl isomerase comprising the steps of:

[0041] (a) providing a first peptidyl/prolyl isomerase having a known three-dimensional structure;

[0042] (b) identifying amino acids in the acive site of said first peptidyl/prolyl isomerase that form close contacts with a compound know to bind to said active site;

[0043] (c) employing protein alignment means to identify in a second peptidyl/prolyl isomerase one or more amino acids that align with, but differ in identity from, said close contact amino acids in said first peptidyl/prolyl isomerase;

[0044] (d) altering an amino acid in the active site of said second peptidyl/prolyl isomerase identified in step (c) to produce a mutant second peptidyl/prolyl isomerase;

[0045] (e) determining that said compound binds with at least 10-fold greater affinity to said mutant second peptidyl/prolyl isomerase than to said second peptidyl/prolyl isomerase, and

[0046] (f) using molecular modeling means to determine how to modify said compound to design an inhibitor of said second peptidyl/prolyl isomerase, wherein said inhibitor binds to said second peptidyl/prolyl isomerase with at least 10-fold greater affinity than said compound binds to said peptidyl/prolyl isomerase, respectively.

[0047] In a related embodiment, the first peptidyl/prolyl isomerase is Pin1. In related embodiments the Pin1 molecule can have one or more conservative amino acid substitutions.

[0048] In a related embodiment, the second peptidyl/prolyl isomerase is selected from the group consisting of hCyP-A, hCyP-B, hCyP-C, NKCA, hFKBP-12, hFKBP-13, Par14 (Uchida, T. et al. (1999) FEBS Lett. 446, 278-282) and hFKBP-25.

BRIEF DESCRIPTION OF THE FIGURES

[0049] FIG. 1 depicts the amino acid sequence of Pin1 (SEQ ID NO:1), and Pin1 R14A (SEQ ID NO:2).

[0050] FIG. 2 is a schematic representation of the defined areas of the polyl isomerase active site of Pin1.

[0051] FIG. 3 depicts the structures of compounds used in crystallized co-complexes of Pin1 R14A, and the structures of derivatives of these compounds.

DETAILED DESCRIPTION

[0052] The features and other details of the invention will now be more particularly described and pointed out in the claims. It will be understood that the particular embodiments of the invention are shown by way of illustration and not as limitations of the invention. The principle features of this invention can be employed in various embodiments without departing from the scope of the invention.

[0053] The present invention is based, at least in part, on the discovery of a model for designing specific inhibitors of Pin1 and Pin1-related proteins using the structure of Pin1 R14A alone and co-complexed to various inhibitors as determined by X-ray crystallography.

[0054] I. Methods of Designing Pin1 Inhibitors

[0055] A. Definitions

[0056] The term “amino acids” refers to L-isomers of the naturally occurring amino acids or unnatural amino acids. Naturally occurring amino acids are glycine, alanine, valine, leucine, isoleucine, serine, methionine, threonine, phenylalanine, tyrosine, tryptophan, cysteine, proline, histidine, aspartic acid, asparagine, glutamic acid, glutamine, γ-carboxyglutamic acid, arginine, omithine and lysine.

[0057] The term “unnatural amino acids” refers to amino acids that are not naturally found in proteins. Examples of unnatural amino acids as used herein, include racemic mixtures of selenocysteine and selenomethionine. In addition, unnatural amino acids include the D or L forms of nor-leucine, para-nitrophenylalanine, homophenylalanine, para-fluoropheynlalanine, 3-amino-2-benzylpropionic acid, homoarginine, and D-phenylalanine.

[0058] The term “positively charged amino acid” refers to any naturally occurring or unnatural amino acid having a positively charged side chain under physiological conditions. Examples of positively charged amino acids include arginine, lysine and histidine.

[0059] The term “negatively charged amino acid” refers to any naturally occurring or unnatural amino acid having a negatively charged side chain under normal physiological conditions. Examples of negatively charged amino acids include aspartic acid and glutamic acid.

[0060] The terms “hydrophobic amino acid” or “nonpolar amino acid” refer to any amino acid having an uncharged, nonpolar side chain that is relatively insoluble in water. Examples of hydrophobic amino acids include alanine, leucine, isoleucine, valine, proline, phenylalanine, tryptophan and methionine.

[0061] The term “hydrophilic amino acid” refers to any amino acid having a uncharged, polar side chain that is relatively soluble in water. Examples of hydrophilic amino acids include serine, threonine, tyrosine, asparagine, glutamine and cysteine.

[0062] The terms “protein” and “polypeptide” are used interchangeably herein. The term “peptide” is used herein to refer to a chain of two or more amino acids or amino acid analogs (including non-naturally occurring amino acids), with adjacent amino acids joined by peptide (—NHCO—) bonds. Thus, peptides in accordance with the invention include oligopeptides, polypeptides, proteins, and peptidomimetics.

[0063] The term “three dimensional coordinate set” refers to mathematical coordinates derived from mathematical equations related to the patterns obtained on diffraction of a monochromatic beam of X-rays by the atoms of a protein molecule in a crystal form. The diffraction data are used to calculate an electron density map of the repeating unit of the crystal. The electron density maps are used to establish the positions of the individual atoms within the unit cell.

[0064] The term “unit cell” refers to the basic parallelepiped shaped block. The entire volume of the crystal may be constructed by regular assembly of such blocks.

[0065] The term “space group” refers to the arrangement of symmetry elements of a crystal.

[0066] The term “Pin1 polypeptide” refers to a polypeptide having a substitution, insertion or deletion of one of more amino acids of SEQ ID NO:1 wherein the active site of the Pin1 polypeptide is accessible to solvent and available for interaction with an inhibitor in a crystallized form. The term “Pin1 polypeptide” can also refer to any folded, globular domain or fragment of the Pin1 protein of SEQ ID NO:1 that is useful in the design of modulators of the Pin1 polypeptide.

[0067] The term “Pin1 related polypeptide” refers to a polypeptide that is homologous or functionally conserved with Pin1 (SEQ ID NO:1).

[0068] The term “Pin1-associated state” or “Pin1 associated disorder” includes disorders and states (e.g., a disease state) which are associated with abnormal cell growth, abnormal cell proliferation, or aberrant levels of Pin1 marker. Pin1-associated states include states resulting from an elevation in the expression of cyclin D1 and/or Pin1. Pin1-associated states also include states resulting from an elevation in the phosphorylation level of c-Jun, particularly phosphorylation of c-Jun on Ser63/73-Pro and/or from an elevation in the level of c-Jun amino terminal kinases (JNKs) present in a cell. Pin1-associated states include neoplasia, cancer, undesirable cell growth, and/or tumor growth. Pin1-associated states include states caused by DNA damage, an oncogenic protein (i.e. Ha-Ras), loss of or reduced expression of a tumor suppressor (i.e. Brcal), and/or growth factors.

[0069] The term “fragment” refers to any portion of the Pin1 polypeptide of SEQ ID NOs: 1 and 2 which retains all, or any portion, of the structural elements of the native polypeptide.

[0070] The term “interacting agent” includes substances which can interact with the Pin1 polypeptide such that the three-dimensional structure can be determined. In one embodiment, the interacting agent is a Pin1 inhibitor, a substrate-derived peptide, or a solvent based molecule.

[0071] The term “co-complex” refers to a Pin1 polypeptide, Pin1 related polypeptide or fragment thereof in covalent or non-covalent association with a chemical entity or compound.

[0072] The term “Pin1 inhibitor” refers to any molecule that can interact with Pin1 or a Pin1-related polypeptide and inhibit the ability of the polypeptide to carry out proline isomerization activity. In certain embodiments, the inhibitor is specific for Pin 1, i.e., does not inhibit the isomerase activity of PPIases belonging to other classes (e.g., cyclophilins or FKBPs).

[0073] A “competitive” inhibitor as used herein is one that inhibits proline isomerase activity by binding to the same kinetic form of the enzyme as its substrate binds, thus directly competing with the substrate for the active site. Competitive inhibition can be reversed completely by increasing the substrate concentration. An “uncompetitive” inhibitor as used herein is one that inhibits proline isomerase activity by binding to a different kinetic form of the enzyme than does the substrate. Such inhibitors bind to the enzyme already bound with the substrate and not to the free enzyme. Uncompetitive inhibition cannot be completely reversed by increasing the substrate concentration. A “noncompetitive” inhibitor as used herein is one that can bind to either the free or substrate bound enzyme.

[0074] The term “WW domain” refers to a 30-40 residue domain that is comprised of a three-stranded anti-parallel β sheet and is known to bind proline-rich or proline-containing ligands. In one embodiment, the WW domain is a fragment of Pin1 that binds phosphorylated protein or peptide substrates.

[0075] The term “hydrophobic pocket” refers to the portion of the active site that binds a hydrophobic moiety. In one embodiment, the hydrophobic pocket contains 4, 6, 8, 10, 12 or 14 hydrophobic amino acid residues. In one particular embodiment, the hydrophobic pocket contains amino acid residues His59, Leu61, Leu122, Met130, Gln131, Phe134, Thr152, and His157 of SEQ ID NO:1.

[0076] The term “cysteine/serine valley” refers to a portion of the active site that is responsible for binding or interacting with the isomerized peptide bond moiety of the substrate. In one embodiment this region contains residues Leu61, Cys113 and Ser154 of SEQ ID NO:1.

[0077] The term “phosphate binding pocket” refers to a region of the active site containing three positively charged amino acids that binds or interacts with negatively charged moieties or hydrogen donor/acceptor groups. In one embodiment, this pocket is contains 4, 6, 8, or 10 amino acid residues. In one particular embodiment, this pocket is defined by residues Lys63, Ser67, Arg68, Arg69, Pro70 and Ser154.

[0078] The term “substrate entry groove” refers to a region of the polypeptide that allows for substrate entry into the active site. In one embodiment this groove contains amino acids Lys63, Arg69, Ser71, Ser72, Trp73, Arg74, Gln75, Glu76, Asp112, Cys113, Ser114.

[0079] The term “lip regions” refers to the residues that surround the active site cavity, as defined previously. In one embodiment these lip regions contain residues that are within 10 Å of the active site cavity. In one particular embodiment, this lip region is defined by, but not limited to, residues Arg54, Arg56, His64, Ser65, Gln66, Lys77, Ile78, Thr79, Ser115, Lys117, Ala118, Gly123, Ala124, Phe125, Ser126, Arg127, Gly128, Gln129, Pro133, Glu135, Lys132, Phe151, Asp153, Gly155, and Ile156.

[0080] The term “hydrophobic pocket interacting moiety” refers to a compound that is capable of interacting with the residues of the hydrophobic pocket. This interaction can be, for example, through hydrophobic interactions, through van der Waals contacts, or through hydrogen bonds.

[0081] The term “cysteine/serine valley interacting moiety” refers to a compound that is capable of interacting with Cys113 or Ser154, i.e., the cysteine/serine valley, within the region of the active site that binds the serine residue of the natural substrate. This interaction can be covalent, noncovalent, throught hydrogen bonds, or by van der Waals interactions.

[0082] The term “phosphate binding pocket interacting moiety” refers to a compound that can interact with the phosphate binding pocket. This interaction can be electrostatic, through salt bridges, covalent, or through van der Waals interactions.

[0083] The term “substrate entry groove interacting moiety” refers to a compound that can interact with the substrate entry groove. This interaction can be electrostatic, hydrophobic, covalent, hydrogen bonding, or through van der Waals interactions

[0084] The term “lip region interacting moiety” refers to a compound that is capable of interacting with the residues outside the active site. This interaction can be, for example through hydrophobic interactions, though van der Waals contacts, or through hydrogen bonds.

[0085] The term “interaction template” refers to a three dimensional model built using information obtained from crystal structures solved with chemical entities bound in the active site. The interaction template is formed by using a Pin1 polypeptide having a substitution insertion or deletion of one or more amino acids of the amino acid sequence set forth in SEQ ID NO:1, wherein the active site of the Pin1 polypeptide is accessible to solvent and available for interaction with a inhibitors. This crystallized form of Pin1 is used to facilitate solving high resolution molecular structures with molecules bound in the active site such that the residues capable of interacting with inhibitors in the active site are determined. The interaction of molecules bound to Pin1 are mapped and characterized by type, distance, and position. The accumulation of interaction information is used to focus the modification of know inhibitors, or to suggest novel design motifs. This template is thus used in the design of high affinity inhibitors of Pin1 isomerase activity.

[0086] The term “specificity template” refers to a template created by comparing sequence and structural alignments of homologous or functionally related proteins. Identification of conserved and non-conserved residues and regions allows a skilled artisan to design inhibitors of prolyl isomerase activity that increase affinity and specificity. The determination of conserved amino acids allows the skilled artisan to develop inhibitors with increased affinity but not, necessarily, specificity. The determination of non conserved amino acids and regions allows the skilled artisan to develop inhibitors that have increased affinity and specificity.

[0087] B. Crystals of Pin1 R14A and Pin1 R14A-Inhibitor Complexes

[0088] The present invention is based, at least in part, on the discovery that crystals of Pin1 polypeptide containing an alanine at position 14 of the amino acid sequence (Pin1 R14A) exhibit properties that are advantageous over the wild-type polypeptide in the crystallized form. The Arg at position 14 is located in the WW domain (Ranganathan, R. et al. Cell 89:875-86). Mutation of the Arg14 residue to a non-charged amino acid results in an alteration within the WW domain structure, resulting in the crystallization of the Pin1 polypeptide in a new crystallization space group of P3121 with unit cell dimensions a=b=68.7 and c=79.4 with α=90′, β=90° and y=120°. The atomic coordinates of Pin1 R14A are listed in FIG. 2.

[0089] The Arg14 mutation does not cause any alteration in the structure of the proline isomerase domain, or in the catalytic ability of Pin1. The resulting crystals are mechanically robust, do not require microseeding to improve crystal size, and diffract to a higher resolution than crystals of the wild-type Pin1 polypeptide. Additionally, these crystals grow in a shorter period of time, typically less than 2 days rather than the 1-2 weeks for the wild-type polypeptide.

[0090] It was therefore determined that the Pin1 R14A crystals are particularly well suited for inhibitor screening by soaking low affinity and nonspecific inhibitors into the active site of a grown crystal. In addition to the previously stated properties, the peptidyl-prolyl cis-trans isomerase active site is exposed within the crystal lattice to the large solvent channels within the crystal. This allows easy access for soluble compounds to the proline isomerase active site within already formed crystals. It also allows for the soaking of Pin1 R14A crystals in solutions containing potential inhibitors, giving the modulator access to bind to the active site. Crystal soaking does not then require a re-optimization of the crystallization conditions, and any number of inhibitors can be screened, thus increasing the speed at which inhibitor-protein structures may be determined. The robust nature of the crystals also facilitates the manipulation and transfer of the crystals into solutions required for soaking potential inhibitors into existing crystals, and for X-ray data collection.

[0091] As described in the Examples, crystals of Pin1 R14A associated in a co-complex with various types of inhibitors were also produced and analyzed. The three-dimensional coordinates for crystals of two of the inhibitors, PIN-077 and PIN-420, bound to the active site of Pin1 R14A are depicted in FIGS. 3 and 4, respectively.

[0092] Data sets collected of Pin1 crystals with molecules bound in the active site allow for elucidation of the residues capable of interacting with inhibitors. Using these data sets, an interaction template can be built that allows the skilled artisan to design inhibitors specific for the Pin1 active site.

[0093] Based on sequence and structural alignments of related enzymes, the phosphate binding pocket has been determined to be a key region for targeting the design for increased interaction and specificity. The crystal structure of the co-complex with inhibitor PIN-077 (the coordinates of which are presented in Table 2) shows that the sulfate moiety of this molecule makes four hydrogen bond contacts in the phosphate binding pocket (with Lys63, Arg69, Ser154, and bound water) and that the hydroxyl groups on the proximal ring hydrogen bond to the nitrogen of the Arg69 sidechain and to Lys63. Investigation of the remainder of the structure demonstrated that the remaining two rings of PIN-077 do not bind in the active site cavity, but rather protrude out of the active site. The structure of citrate bound in the phosphate pocket (the coordinates of which are presented in Table 6), provides another acidic moiety type bound in the phosphate pocket. The citrate makes hydrogen bond contacts with Lys63 and Arg69. Both examples are integrated into the interaction template by providing a preferred interaction pattern, along with unique type, distance, and linking atoms.

[0094] Interestingly, the hydrophobic pocket has a role in binding the proline residue of the substrate, and has a variety of motifs which bind into this active site region. Based on the specificity template, this region will be less specific, but will increase binding affinity. In the Pin R14A/Pin-077 crystal structure it was observed that a polyethylene glycol molecule was bound in the hydrophobic pocket showing the formation of a hydrogen bond between the hydroxyl group of the polyethylene glycol molecule and a backbone nitrogen atom (Gln131) of the Pin1 polypeptide. A hydrogen bond between Gln131 backbone nitrogen atom and an oxygen atom on the bound ligand was also observed with inhibitor Pin-420, N-methylpyrroleidone, and glycerol. The preferred placement of an oxygen atom at this position is thus incorporated and emphasized in the interaction template.

[0095] The crystal structure of the co-complex with PIN-420 shows that this molecule binds into the hydrophobic pocket, making contact with Gln131 and Met130. PIN-420 also initeracts with residues in the cysteine/serine valley, Cys113 and Ser154. PIN-420 alters the local protein environment by disrupting the hydrogen bond observed in other structures between Gln131 and Ser154. These residues sidechains no longer interact with each other, but rather form hydrogen bonds to PIN-420.

[0096] Accordingly, in one aspect the invention features a crystallized Pin1 polypeptide containing an amino acid other than arginine at position 14 of the polypeptide sequence. In certain embodiments, the amino acid at position 14 is also non-polar, and in one preferred embodiment, the amino acid at position 14 is alanine. In related embodiments, the invention pertains to crystals of any part or fragment of a Pin1 polypeptide of the invention that contains the residues that comprise the isomerase active site (e.g., fragments of Pin1 R14A).

[0097] In a related aspect, the invention also pertains to crystals of the Pin1 polypeptides containing an amino acid other than arginine at position 14 in a co-complex with an inhibitor of the Pin1 polypeptide. In certain embodiments, the amino acid at position 14 is also a non-polar amino acid, and in one preferred embodiment, the amino acid at position 14 is alanine. In other embodiments, the crystallized co-complexes contain Pin1 R14A or fragments thereof.

[0098] The crystallized Pin1 polypeptides and crystallized Pin1 polypeptide/inhibitor co-complexes are obtained by growing the crystals under appropriate conditions such that the three-dimensional structure can be determined using methods described herein and/or art recognized techniques. For example, Pin1 crystals of Pin1 can be grown by a number of techniques including batch crystallization, vapor diffusion (either by sitting drop or hanging drop), or by microdialysis. Once a crystal has been obtained X-ray diffraction data can be collected. Similarly, the crystallized co-complexes of this aspect of the invention can be obtained by growing the crystal in the presence of the inhibitor, or can be obtained by first growing the crystal to the appropriate size, followed by soaking said crystal in a solution that contains an inhibitor.

[0099] The term “appropriate conditions” include those conditions which result in the formation of a crystal which can be analyzed to a resolution of 5.0 Å, 4.0 Å, 3.0 Å, 2.0 Å or greater. In one embodiment, the temperature of crystallization of the Pin1 polypeptide is from about 1° C. to about 30° C., from about 1° C. to about 25° C., from about 1° C. to about 15° C., from about 1° C. to 10° C., or about 4° C. In a further embodiment, the conditions are selected such that crystals of the Pin1 polypeptide grow within an acceptable time and reach dimensions that are suitable for structural determination, e.g., by using X-ray diffraction. In certain embodiments, the acceptable time for crystal growth is 1 week or less, 5 days or less, 4 days or less, 3 days or less, or, advantageously, 2 days or less. In related embodiments, the dimensions of the crystal are 0.05 mm or greater per side, 0.1 mm or greater per side, 0.2 mm or greater per side, or approximately 0.3 mm per side or greater. Still other embodiments are presented in the Examples described herein.

[0100] C. Designing Inhibitors of Pin1 Based on the Structure Coordinates of Pin1 R14A and Pin1 R14A-Inhibitor Co-Complexes

[0101] The crystallized Pin1 R14A and Pin1 R14A-inhibitor complexes have, for the first time, provided structural information that has enabled identification of the regions of the Pin1 polypeptide involved in the molecular interaction with Pin1 inhibitors, thereby providing methods for identifying specific inhibitors of Pin1. By comparison of the crystal structures of Pin1 R14A and the Pin1 R14A-inhibitor complexes described herein, potential sites for modification within the inhibitors have been identified providing an important tool for determining the most efficient binding interactions between Pin1 and a potential inhibitor.

[0102] The Pin1 polypeptide consists of two structural domains organized around a hydrophobic cavity. The N-terminal WW domain, defined as residues 1-39 and a C-terminal proline isomerase domain, defined as residues 45-163. The WW domain is a three-stranded anti-parallel β-sheet. The C-terminal proline isomerase domain is a 4 stranded anti-parallel β-sheet surrounded by 4 α helices (e.g., Ranganathan, et al. Cell 89:875-886, 1997; Verdecia et al., Nat Struct Biol 7(8):639-43, 2000).

[0103] Based on the comparison of the structural coordinates of the crystals of Pin1 R14A and co-complexes, five regions of the active site involved in key interactions which define Pin1 enzyme activity and specificity were elucidated. As shown in FIG. 9, these regions include the following:

[0104] The “hydrophobic pocket” is composed of residues His59, Leu61, Leu122, Met130, Gln131, Phe134, Thr152, His157 of Pin1 (SEQ ID NO.1). This pocket binds the hydrophobic side chain of the substrate proline.

[0105] Residues Leu61, Cys113, and Ser154 in the active site are here defined as a “cysteine/serine valley”, residing between the “hydrophobic pocket” and the “phosphate binding pocket”. The isomerized peptide bond of an alanine-proline dipeptide was found to be located in this region.

[0106] The third region is the basic “phosphate binding pocket” consisting of a region of high localized positive charge and is defined with amino acids Lys63, Ser67, Arg68, Arg69, Pro70, and Ser154. This region is part of the specificity loop (amino acids 64-80) for the phosphate-specific recognition by Pin1 of phosphorylated serine/threonine peptide substrates which are uniquely recognized and isomerized the Pin1 family of proline isomerases, in contrast to FK506 binding proteins and cyclophilins.

[0107] A fourth region is the “substrate entry groove” as defined by the following amino acids: Lys63, Arg69, Ser71, Ser72, Trp73, Arg74, Gln75, Glu76, Asp112, Cys113, Ser114.

[0108] A fifth region is the “lip region” as defined by the residues that immediately surround the active site cavity, as defined previously. In one embodiment these lip regions contain residues that are within 10 Å of the active site cavity. In one particular embodiment, this lip region is defined by, but not limited to, residues Arg54, Arg56, His64, Ser65, Gln66, Lys77, Ile78, Thr79, Ser115, Lys117, Ala118, Gly123, Ala124, Phe125, Ser126, Arg127, Gly128, Gln129, Pro133, Glu135, Lys132, Phe151, Asp153, Gly155, and Ile156.

[0109] Accordingly, in another aspect, the invention provides a method of designing specific inhibitors of Pin1 isomerase activity based on the ability of molecules to bind to one or more of the defined regions of the Pin1 proline isomerase active site.

[0110] In one embodiment, the method uses the structure coordinates of Pin1 R14A and/or Pin1 R14A-inhibitor complexes to design compounds that bind to at least one of the regions of the active site. In certain embodiments, the compounds are designed to bind at least one, preferably to at least two, more preferably at least three, four, or five regions of the active site.

[0111] In another embodiment, the method uses a crystal of Pin1R14A probed with molecules composed of a variety of different chemical moieties to determine optimal sites for interaction between candidate Pin1 inhibitors and the enzyme. For example, small molecules that bind tightly to one or more of the regions of the active site can be designed and tested for their ability to inhibit Pin1 isomerase activity using the assays described herein.

[0112] Another method included in this aspect of the invention is to computationally screen small molecule databases for chemical entities that can bind in whole, or in part to, to one or more of the regions of the Pin1 active site. In one embodiment of this method, the quality or fit of the compound identified to the regions of the Pin1 active site can be judged either by shape complementarity or by estimated interaction energy (Meng et al., J. Comp. Chem. 13:505-524, 1992).

[0113] In a further embodiment, potential inhibitors that can be analyzed according to the methods of the invention can be obtained using any of the numerous approaches in combinatorial library methods known in the art. In this embodiment, potential inhibitors are first identified for Pin1 inhibitory activity using the in vitro assays described herein. Once potential inhibitors are identified, and their structures determined, further optimization can be carried out by computational analyses using the structure coordinates of the Pin1 R14A and Pin1R14A-co-complexes described herein. Alternatively, further optimization can be carried out by determining the structural coordinates of crystallized co-complexes of the potential inhibitor and Pin1 R14A using the methods described herein.

[0114] Various combinatorial libraries that can be used in the methods of the invention include, but are not limited to: biological libraries; spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring deconvolution; the ‘one-bead one-compound’ library method; and synthetic library methods using affinity chromatography selection. The biological library approach is limited to peptide libraries, while the other four approaches are applicable to peptide, non-peptide oligomer or small molecule libraries of compounds (Lam (1997) Anticancer Drug Des. 12:145).

[0115] Further, examples of methods for the synthesis of molecular libraries can be found in the art, for example in: DeWitt et al. (1993) Proc. Natl. Acad. Sci. U.S.A. 90:6909; Erb et al. (1994) Proc. Natl. Acad. Sci. USA 91:11422; Zuckermann et al. (1994). J. Med. Chem. 37:2678; Cho et al. (1993) Science 261:1303; Carrell et al. (1994) Angew. Chem. Int. Ed. Engl. 33:2059; Carell et al. (1994) Angew. Chem. Int. Ed. Engl. 33:2061; and in Gallop et al. (1994) J. Med. Chem. 37:1233.

[0116] Libraries of compounds may be presented in solution (e.g., Houghten (1992) Biotechniques 13:412-421), or on beads (Lam (1991) Nature 354:82-84), chips (Fodor (1993) Nature 364:555-556), bacteria (Ladner U.S. Pat. No. 5,223,409), spores (Ladner U.S. Pat. No. '409), plasmids (Cull et al. (1992) Proc Natl Acad Sci USA 89:1865-1869) or on phage (Scott and Smith (1990) Science 249:386-390); (Devlin (1990) Science 249:404-406); (Cwirla et al. (1990) Proc. Natl. Acad. Sci. 87:6378-6382); (Felici (1991) J. Mol. Biol. 222:301-310); (Ladner supra.).

[0117] The potential inhibitory effect of a compound can be further analyzed prior to its actual synthesis and testing by use of computer modeling techniques using the structural coordinates of the Pin1 R14A and Pin1 R14A-inhibitor co-complexes described herein. If the computer modeling indicates a strong interaction, the molecule can then be synthesized using standard methods known to those skilled in the chemical arts, and then tested for its ability to inhibit Pin1 isomerase activity using the assays set forth herein.

[0118] An inhibitory or other binding compound of Pin1 may be computationally evaluated and designed by means of a series of steps in which chemical entities or fragments are screened and selected for their ability to associate with the individual binding pockets or other areas of Pin1.

[0119] In other embodiments of the method of the invention, potential inhibitory compounds can be examined for their ability to associate with Pin1 and more particularly with the five regions of the Pin1 active site. This process can involve visual inspection of, for example, the active site on a computer screen based on the coordinates of the Pin1 R14A and Pin1 R14A-inhibitor complex as set forth in Tables 1-6. Selected compounds or chemical moieties can then be positioned in a variety of orientations, or docked, within an individual region of the Pin1 active site as defined herein. Docking can be accomplished using software such as Quanta and SYBYL, followed by energy minimization and molecular dynamics with standard molecular mechanics forcefields, such as CHARMM and AMBER.

[0120] Specialized computer programs that can also be used in the process of selecting compounds or chemical entities include:

[0121] 1. SYBYL Available from Tripos Inc., 1699 South Hanley Rd., St. Louis, Mo., 63144, USA

[0122] 2. UNITY Available from Tripos Inc., 1699 South Hanley Rd., St. Louis, Mo., 63144, USA

[0123] 3. FlexX Available from Tripos Inc., 1699 South Hanley Rd., St. Louis, Mo., 63144, USA

[0124] 4. GRID (Goodford, P. J., “A Computational Procedure for Determining Energetically Favorable Binding Sites on Biologically Important Macromolecules”, J. Med. Chem., 28, pp. 849-857 (1985)). GRID is available from Oxford University, Oxford, UK.

[0125] 5. MCSS (Miranker, A. and M. Karplus, “Functionality Maps of Binding Sites: A Multiple Copy Simultaneous Search Method.” Proteins: Structure. Function and Genetics, 11, pp. 29-34 (1991)). MCSS is available from Molecular Simulations, Burlington, Mass.

[0126] 6. AUTODOCK (Goodsell, D. S. and A. J. Olsen, “Automated Docking of Substrates to Proteins by Simulated Annealing”, Proteins: Structure. Function, and Genetics, 8, pp. 195-202 (1990)). AUTODOCK is available from Scripps Research Institute, La Jolla, Calif.

[0127] 7. DOCK (Kuntz, I. D. et al., “A Geometric Approach to Macromolecule-Ligand Interactions”, J. Mol. Biol., 161, pp. 269-288 (1982)). DOCK is available from University of California, San Francisco, Calif.

[0128] Once suitable compounds or chemical moieties have been selected, they can be assembled into a single compound or inhibitor. Assembly may be proceed by visual inspection of the relationship of the compounds or moieties to each other on the three-dimensional image displayed on a computer screen in relation to the structure coordinates of Pin1, Pin1 R14A and/or Pin1 R14A-inhibitor co-complexes. This could then be followed by manual model building using software such as Quanta or SYBYL.

[0129] Other useful programs to aid one of skill in the art in connecting the individual compounds or chemical entities include:

[0130] 1. CAVEAT (Bartlett, P. A. et al, “CAVEAT: A Program to Facilitate the Structure-Derived Design of Biologically Active Molecules”. In “Molecular Recognition in Chemical and Biological Problems”, Special Pub., Royal Chem. Soc., 78, pp. 182-196 (1989)). CAVEAT is available from the University of California, Berkeley, Calif.

[0131] 2. 3D Database systems such as MACCS-3D (MDL Information Systems, San Leandro, Calif.). This area is reviewed in Martin, Y. C., “3D Database Searching in Drug Design”, J. Med. Chem., 35, pp. 2145-2154 (1992)).

[0132] 3. HOOK (available from Molecular Simulations, Burlington, Mass.).

[0133] In other embodiments, Pin1 inhibitors can be designed as a whole or “de novo” using either an empty active site or optionally including some portion(s) of a known inhibitor(s), e.g., PIN-051 and/or PIN-077, as described herein. Programs which can aid in these methods include:

[0134] 1. LUDI (Bohm, H.-J., “The Computer Program LUDI: A New Method for the De Novo Design of Enzyme Inhibitors”, J. Comp. Aid. Molec. Design, 6, pp. 61-78 (1992)). LUDI is available from Biosym Technologies, San Diego, Calif.

[0135] 2. LEGEND (Nishibata, Y. and A. Itai, Tetrahedron, 47, p. 8985 (1991)). LEGEND is available from Molecular Simulations, Burlington, Mass.

[0136] 3. LeapFrog (available from Tripos Associates, St. Louis, Mo.).

[0137] Other molecular modeling techniques may also be employed in accordance with this invention. See, e.g., Cohen, N. C. et al., “Molecular Modeling Software and Methods for Medicinal Chemistry”, J. Med. Chem., 33, pp. 883-894 (1990). See also, Navia, M. A. and M. A. Murcko, “The Use of Structural Information in Drug Design”, Current Opinions in Structural Biology, 2, pp. 202-210 (1992).

[0138] Once a compound has been designed or selected by the above methods, the efficiency with which that compound inhibits Pin1 can be tested and optimized by computational evaluation. For example, a compound that has been designed or selected to function as a Pin1-inhibitor must also preferably traverse a volume not overlapping that occupied by the active site when it is bound to the native substrate. An effective Pin1 inhibitor must preferably demonstrate a relatively small difference in energy between its bound and free states (i.e., a small deformation energy of binding).

[0139] A compound designed or selected as an inhibitor of Pin1 can be further computationally optimized so that in its bound state it would preferably lack repulsive electrostatic interaction with the target enzyme. Such non-complementary (e.g., electrostatic) interactions include repulsive charge-charge, dipole-dipole and charge-dipole interactions. Specifically, the sum of all electrostatic interactions between the inhibitor and the enzyme when the inhibitor is bound to Pin1 preferably make a neutral or favorable contribution to the enthalpy of binding.

[0140] Specific computer software is available in the art to evaluate compound deformation energy and electrostatic interaction. Examples of programs designed for such uses include: Gaussian 92, revision C, M. J. Frisch, Gaussian, Inc., Pittsburgh, Pa.; AMBER, version 4.0, P. A. Kollman, University of California at San Francisco; QUANTA/CHARMM, Molecular Simulations, Inc., Burlington, Mass.; and Insight II/Discover (Biosysm Technologies Inc., San Diego, Calif.). These programs may be implemented, for instance, using a Silicon Graphics workstation, IRIS 4D/35 or IBM RISC/6000 workstation model 550. Other hardware systems and software packages will be known to those skilled in the art.

[0141] Once a Pin1 inhibitor has been optimally selected or designed, as described herein, substitutions can then be made in some of its atoms or side groups in order to improve or modify its binding properties, again using the information provided by the interaction and specificity templates to identify regions amiable to modification. Generally, initial substitutions are conservative, i.e., the replacement group will have approximately the same size, shape, hydrophobicity and charge as the original group. It should, of course, be understood that components known in the art to alter conformation should be avoided. Such substituted chemical compounds may then be analyzed for efficiency of fit to Pin1 by the same computer methods described in detail, above.

[0142] Designed inhibitors can be further evaluated using in vivo or in vitro assays.

[0143] D. Assays

[0144] Cellular and Cell-Free Assays

[0145] Determining the ability of the Pin1 polypeptide to bind to a compound of the invention can also be accomplished by determining direct binding. Determining the ability of the Pin1 protein to bind to a potential inhibitor can be accomplished, for example, by coupling the Pin1 protein with a radioisotope or enzymatic label such that binding of the Pin1 protein to the potential inhibitor can be determined by detecting the labeled Pin1 protein in a complex. For example, Pin1 molecules, e.g., Pin1 proteins, can be labeled with 125I, 35S, 14C, or 3H, either directly or indirectly, and the radioisotope detected by direct counting of radioemmission or by scintillation counting. Alternatively, Pin1 molecules can be enzymatically labeled with, for example, horseradish peroxidase, alkaline phosphatase, or luciferase, and the enzymatic label detected by determination of conversion of an appropriate substrate to product.

[0146] In other embodiments, determining the ability of the inhibitor to bind to Pin1 can be determined by detecting induction of a downstream event (e.g., expression of cyclin D1, mitosis etc.), detecting the induction of a reporter gene (comprising a target-responsive regulatory element (e.g. AP-1) operatively linked to a nucleic acid encoding a detectable marker, e.g., chloramphenicol acetyl transferase), or detecting another Pin1-regulated cellular response.

[0147] In another embodiment, the assay is a cell-free assay in which a Pin1 protein or biologically active portion thereof is contacted with a test compound and the ability of the test compound to inhibit the activity of the Pin1 protein or biologically active portion thereof is determined. Determining the ability of the test compound to inhibit the activity of a Pin1 protein can be accomplished, for example, by determining the ability of the Pin1 protein to bind to a Pin1 target molecule by one of the methods described above for determining direct binding. Determining the ability of the Pin1 protein to bind to a Pin1 target molecule can also be accomplished using a technology such as real-time Biomolecular Interaction Analysis (BIA). Sjolander, S. and Urbaniczky, C. (1991) Anal. Chem. 63:2338-2345 and Szabo et al. (1995) Curr. Opin. Struct. Biol. 5:699-705. As used herein, “BIA” is a technology for studying biospecific interactions in real time, without labeling any of the interactants (e.g., BLAcore). Changes in the optical phenomenon of surface plasmon resonance (SPR) can be used as an indication of real-time reactions between biological molecules.

[0148] In an alternative embodiment, determining the ability of the test compound to inhibit the activity of a Pin1 protein can be accomplished by determining the ability of the Pin1 protein to further modulate the isomerization of the activity of a Pin1 target molecule (e.g., a Pin1 substrate, a phosphoprotein). For example, the activity of the effector molecule on an appropriate target can be determined, or the binding of the effector to an appropriate target can be determined as previously described.

[0149] In yet another embodiment, the cell-free assay involves contacting a Pin1 protein or biologically active portion thereof with a known compound which binds the Pin1 protein to form an assay mixture, contacting the assay mixture with a test compound, and determining the ability of the test compound to interact with the Pin1 protein, wherein determining the ability of the test compound to interact with the Pin1 protein comprises determining the ability of the Pin1 protein to preferentially bind to or modulate the activity of a Pin1 target molecule.

[0150] In more than one embodiment of the above assay methods of the present invention, it may be desirable to immobilize either Pin1 or its target molecule to facilitate separation of complexed from uncomplexed forms of one or both of the proteins, as well as to accommodate automation of the assay. Binding of a test compound to a Pin1 protein, or interaction of a Pin1 protein with a target molecule in the presence and absence of a candidate compound, can be accomplished in any vessel suitable for containing the reactants. Examples of such vessels include microtitre plates, test tubes, and micro-centrifuge tubes. In one embodiment, a fusion protein can be provided which adds a domain that allows one or both of the proteins to be bound to a matrix. For example, glutathione-S-transferase/Pin1 fusion proteins or glutathione-S-transferase/target fusion proteins can be adsorbed onto glutathione sepharose beads (Sigma Chemical, St. Louis, Mo.) or glutathione derivatized microtitre plates, which are then combined with the test compound or the test compound and either the non-adsorbed target protein or Pin1 protein, and the mixture incubated under conditions conducive to complex formation (e.g., at physiological conditions for salt and pH). Following incubation, the beads or microtitre plate wells are washed to remove any unbound components, the matrix immobilized in the case of beads, complex determined either directly or indirectly, for example, as described above. Alternatively, the complexes can be dissociated from the matrix, and the level of Pin1 binding or activity determined using standard techniques.

[0151] Other techniques for immobilizing proteins on matrices can also be used in the assays of the invention. For example, either a Pin1 protein or a Pin1 target molecule can be immobilized utilizing conjugation of biotin and streptavidin. Biotinylated Pin1 protein or target molecules can be prepared from biotin-NHS (N-hydroxy-succinimide) using techniques well known in the art (e.g., biotinylation kit, Pierce Chemicals, Rockford, Ill.), and immobilized in the wells of streptavidin-coated 96 well plates (Pierce Chemical). Alternatively, antibodies reactive with Pin1 protein or target molecules but which do not interfere with binding of the Pin1 protein to its target molecule can be derivatized to the wells of the plate, and unbound target or Pin1 protein trapped in the wells by antibody conjugation. Methods for detecting such complexes, in addition to those described above for the GST-immobilized complexes, include immunodetection of complexes using antibodies reactive with the Pin1 protein or target molecule, as well as enzyme-linked assays which rely on detecting an enzymatic activity associated with the Pin1 protein or target molecule.

[0152] Tumor Inhibition Assays

[0153] In vitro anti-tumor activity of the Pin1-inhibitor compounds of the invention can be assayed by measuring the ability of the compound to kill tumor cells. Examples of appropriate cell lines include: human lung (A549); resistant human lung with low topo II activity (A549-VP); murine melanoma (B16); human colon tumor (HCT116); human clone tumor with elevated p170 levels (HCTVM); human colon tumor with low topo II activity (HCTVP); P388 murine lymph leukemia cells; and human colon carcinoma cell line (Moser)

[0154] Tumor inhibition assays are described, for example, in Kelly, et al., U.S. Pat. No. No. 5,166,208, and in Pandley, et al., J. Antibiot. 3(11):1389-401 (1981). In one assay, the cells are allowed to grow for a 24 hour period under standard conditions. After the cells are allowed to attach to the plate for 24 hours (e.g., a 96-well flat bottom plate), the cells are incubated for 72 hours with serially diluted concentrations of the Pin1 inhibitor compound. From these data, the concentration of the compound at which 50% of the cells are killed or growth inhibited (IC50) is determined.

[0155] In vivo anti-tumor activity of Pin1 inhibitor compounds of the invention can be assayed by a reduction of tumor cells in mammals (e.g., mice) and a resulting increase in survival time compared to untreated tumor bearing animals. For example, CDF1 mice are injected interperitoneally with a suspension of P388 murine lymph leukemia cells, Ehrlich carcinoma cells, B16 melanoma cells, or Meth-A fibrosarcoma cells. Some of the injected mice are then treated interperitoneally with a Pin1 inhibitor compound of the invention, and other mice are treated with saline. The in vivo activity of the compound is then determined in terms of the % T/C which is the ratio of the mean survival time of the treated group to the mean survival time of the saline treated group times 100. Yokoi, et al., U.S. Pat. No. 4,584,377; Kelly, et al., U.S. Pat. No. 5,155,208; Warnick-Pickle, et al., J. Antibiot. 34(11):1402-7 (1981); and Pandley et al., supra.

[0156] The in vivo anti-tumor activity of the Pin1 inhibitor compounds of the invention can also be assayed against an ovarian tumor growing in a human tumor cloning system as described, for example, in Tebbe, et al., J. Am. Chem. Soc. 93:3793-3795 (1971).

[0157] Specificity Assays for Pin1 Inhibitors

[0158] The specificity of the Pin1 inhibitor compounds of the invention can be determined by the protease-coupled PPIase assay developed by Fischer et al. (Biomed. Biochim. Acta, 1984, 43: 1101-1111). For example, the enzyme activity of Pin1 can be compared to members of the other known classes of PPIases, cyclophilins (e.g., hCyp18, hCyP-A, hCyP-B, hCyP-C, and NKCA) and FKBPs (e.g., hFKBP12, hFKBP-12, hFKBP-13, and hFKBP-25) in the presence and absence of the compound.

[0159] In one assay, hPin1 activity measurements are determined using bovine trypsin (final concentration 0.21 mg/mL, Sigma) as an isomer specific protease and Ac-Ala-Ala-Ser(P)-Pro-Arg-pNA (Jerini, Germany) as a substrate. PPIase activity of hFKBP12 (Sigma) and hCyp 18 (Sigma) is determined with the peptide substrate Suc-Ala-Phe-Pro-Phe-pNA (B achem) and the protease α-chymotrypsin (final concentration 0.41 mg/mL, Sigma). The test can be performed by observing the released 4-nitroanilide at 390 nm with a Hewlett-Packard 8453 UV-vis spectrophotometer at 110° C. The total reaction volume is adjusted to 1.23 mL by mixing appropriate volumes of 35 mM HEPES (pH 7.8) with enzyme and effector solutions. The Pin1 inhibitor compound is freshly diluted from a 1 mg/mL stock solution in DMSO, and pre-incubated at varying concentrations with the enzyme for 5 min (10° C.). Prior to the start of reaction by addition of the respective protease, 2 μL of the peptide substrate stock solution (10 mg/mL in DMSO) is added. The amount of organic solvent is kept constant within each experiment (<0.1%). The pseudo-first-order rate constant kobs for cis/trans isomerization in the presence of PPIase and the first-order rate constant k0 of the uncatalyzed cis/trans isomerization can be calculated using the Kinetics Software of Hewlett-Packard as well as SigmaPlot2000 for Windows 6.0 (SPSS). The Ki value for inhibition of Pin1 PPIase activity by a Pin1 inhibitor compound of the invention at constant concentrations of substrate ([S0]<<KM) can then be calculated by fitting the data according to the equation for a competitive “tight-binding” inhibitor using SigmaPlot2000.

[0160] II. Methods of Designing Inhibitors of Pin1 Related Molecules

[0161] In another aspect, the present invention pertains to methods of designing inhibitors of Pin1-related molecules. In one embodiment of this aspect, the invention provides a method for designing Pin1-like proline isomerase inhibitors. The method comprises one or more of the following steps:

[0162] 1. Development of a three-dimensional interaction template for ligand binding to the five regions of the active site as described above;

[0163] 2. Sequence and structural alignments to determine sequence conservation and divergence among Pin1-like protein domains and other proline-isomerases to identify amino acids unique and essential to the specificity of Pin1-like proline isomerases, thereby creating a specificity template;

[0164] 3. Design specific inhibitors of Pin1 proline isomerases using the interaction template and the specificity template;

[0165] 4. Confirmation of increased affinity and specificity of designed compounds through biochemical assay; and

[0166] 5. Conformation of interaction of designed compounds through crystallographic analysis.

[0167] In one embodiment, the Pin1-like polypeptide comprises one or more conservative mutations as compared to the wild type protein. These mutations can be at any point in the polypeptide that will not alter the function of Pin1. In certain embodiments, the mutation is a hydrophobic substitution at residue 14, and in one particular embodiment, the mutation is a substitution of alanine at position 14 of the Pin1 amino acid sequence of SEQ ID No:1.

[0168] In another embodiment, the Pin1-like polypeptide is a Pin1 homologue. The designed inhibitor should bind tightly to the isomerase and significantly inhibit the activity of the isomerase. In a preferred embodiment, the first isomerase is a peptidyl prolyl isomerase. Even more preferred is that the first isomerase be Pin1 having the amino acid sequence set forth in SEQ ID NO:1.

[0169] In certain embodiments the inhibitors have a Ki for Pin1 of less than 0.2 mM, less than 0.1 mM, less than 750 uM, less than 500 uM, less than 250 uM, less than 100 uM, less than 50 uM, less than 500 nM, less than 250 nM, less than 50 nM, less than 10 nM, less than 5 nM, less than 3 nM, less than 1 nM, or less than 0.5 nM.

[0170] In related embodiments the Pin1 inhibitor of the invention is intended to include inhibitors that have a Ki or Kd that is at least 2, 3, 4, 5, 10, 15, or 20 times less than the Ki or Kd for other peptidyl prolyl isomerases, e.g., hCyP-A, hCyP-B, hCyP-C, NKCA, hFKBP-12, hFKBP-13, and hFKBP-25.

[0171] In another embodiment, the Pin1-like polypeptide includes cylophilins (e.g., hCyP-A, hCyP-B, hCyP-C, and NKCA) and other FKBPs (e.g., hFKBP-12, hFKBP-13, and hFKBP-25). Sequence alignments of Pin1 and Pin1-like proteins can be carried out to identify amino acids unique and essential to the specificity of the individual proline isomerase active site.

[0172] Compounds of the Invention

[0173] Pin1 inhibitors of the invention include molecules that interact with one or more regions of the proline isomerase active site through covalent or non-covalent interactions. In certain embodiments, the inhibitor will contain moieties that interact with one or more regions of the active site wherein the moieties are covalently linked. In other embodiments the inhibitor can consist of one or more molecules, each of which interact with a different region of the active site. In preferred embodiments, the inhibitors interact with at least one, preferably at least two, more preferably at least three, and most preferably four regions of the Pin1 active site.

[0174] In one particular embodiment, the Pin1 inhibitor comprises some or all: (1) a hydrophobic portion that localizes to the hydrophobic pocket of the Pin1 polypeptide; (2) the placement of a peptide-like like motif in the cysteine/serine valley; (3) a negatively charged or uncharged moiety that interacts with the basic pocket through charge-charge interactions, hydrogen-bond interactions or favorable steric interactions; (4) the ability to replace water molecules in contact with the active site regions; and (5) interactions outside the active site, gaining interaction with the lip regions.

[0175] In certain embodiments, the Pin1 inhibitors have the structure:

[0176] A-B-C-D-E

[0177] wherein A is a hydrophobic pocket binding moiety, B is a cysteine/serine valley binding moiety, C is phosphate pocket binding moiety, D is a substrate groove interacting moiety, and E is a lip region interacting moiety.

[0178] The invention is further illustrated by the following examples, which should not be construed as further limiting. The contents of all references, pending patent applications and published patents, cited throughout this application are hereby expressly incorporated by reference. The animal models used throughout the Examples are accepted animal models and the demonstration of efficacy in these animal models is predictive of efficacy in humans.

EXAMPLES

Example 1

Crystallization and Structural Determination of Pin1 R14A

[0179] Production of Pin1 R14A:

[0180] An N-terminal histidine tagged fusion protein of the Pin1 R14A mutant is expressed in E. coli. The bacteria is grown using Terrific Broth at 37° C. The expression vector (a pET28a derivative) contains Kanamycin resistance, and the protein is induced by lowering the temperature to 20° C. and adding IPTG to 50 μM. After 6-8 hours the bacteria is harvested by centrifugation and stored at −80° C.

[0181] Purification of Pin1 R14A:

[0182] The purification of Pin1 R14A is based on the modified method of Ranganathan et al. (Cell 1997, 89, 875-886). The E. coli pellet is thawed and suspended at 5 mL per gram in 50 mM Tris (pH 8.0), 500 mM NaCl, 20 mM Imidazole (pH 8.0), 10% glycerol, 1% Tween 20, and 25 mM β-mercaptoethanol. Lysozyme (hen egg white) is added at 0.5 mg/mL and the solution stirred for 30 min at room temperature. The cells were disrupted by sonication, and the solution clearified by centrifugation. The extract was then applied to a 5 mL column of Qiagen Ni-NTA resin at a 1-2 mL/min flow rate. The column was washed with three column volumes of the above buffer, and then bound protein was eluted from the resin with 50 mM Tris (pH 8.0), 500 mM NaCl, 250 mM Imidazole (pH 8.0), and 10% glycerol. Fractions containing protein were pooled and thrombin was added at 0.5 μL/mL of 1 U/μL. The material was placed in a dialysis bag and dialyzed overnight against 50 mM Tris (pH 8.0), 500 mM NaCl, and 25 mM β-mercaptoethanol. The material is then passed through a 0.5 mL column of Qiagen Ni-NTA resin at 1 mL/min, and 0.25 mL column of Benzamidine-Sepharose at 1 mL/min. After concentration, the material was loaded onto a FPLC size-exclusion column (Superdex 75, HiLoad 16/60, Pharmacia). Fractions containing Pin1 R14A were concentrated and dialyzed against 10 mM HEPES (pH 7.5), 20 mM NaCl, 1 mM DTT. After dialysis, the material was concentrated to 15-20 mg/mL. Material not used immediately was stored at −80° C. Milligram quantities of purified Pin1 R14A are obtained from a liter of bacterial culture.

[0183] Crystallization of Pin1 R14A:

[0184] The protein is crystallized by screening against 1.8-2.05 M Ammonium sulfate, 1% PEG 400, 0.1 M HEPES (pH 7.5), 1 mM DTT. Crystallization is performed using the hanging drop method in a Linbro style plate, with 1 mL solution in the reservoir. Siliconized glass cover slips are inverted over the reservoir after mixing 2 μL protein solution and 2 μL reservoir solution. Trays are wrapped in foil and placed at 4° C. Crystal growth is observable within two days. Crystal growth was shortened to 2-3 days rather than 1-2 weeks for the wild-type protein, and crystal seeding techniques were not required to obtain sufficiently large crystals.

[0185] Crystals can be grown from 0.9-1.2 M Sodium citrate, 1% PEG 400, 0.1 M HEPES (pH. 7.5), 5 mM DTT, with 0-5% glycerol.

[0186] Transfer of Pin1 R14A Crystals to Cryoprotectant:

[0187] The crystals are transferred directly into cryoprotection solutions (i) 30% PEG 400, 100 mM HEPES (pH 7.5), 1 mM DTT, or (ii) 25% MPD, 100 mM HEPES (pH 7.5) or (iii) 30% PEP, 100 mM HEPES (pH 7.5). Crystal transfer to the cryoprotection solution is necessary to preserve the crystal during cooling to −180° C. for data collection, and also to allow compounds to bind under low salt conditions, which is important to increase the solubility of the compounds and to remove the sulfate ion bound in the active site (placed by crystallization conditions, but removable upon soaking for several days).

[0188] Data Collection and Processing:

[0189] Data collection on a rotating anode X-ray generator is typically 6 hours, using 1 degree of oscillation and 5 minute exposure times. An oscillation range of 60 degrees is required for a complete data set. The conversion of Arg14 to Ala is located in WW domain of Pin1. This mutation results in an altered and favorable crystallization space group of P3121. The crystals are mechanically robust and diffract to high resolution (˜1.9 Å). The images were processed and scaled using Denzo and Scalepack (Z. Otwinowski et al., Meth. Enzymol., 1996, 276, 307-326). Molecular replacement (using PDB entry IPIN as the original search model) and refinement was done with CNX (A. Brunger et al., Acta Cryst. (1990), D54, 905-921), model building was done with 0 (Jones, T. A., Zou, J. Y. Cowan, S. W. & Kjelgaard, M. Acta Cryst. A 47, 110-119 (1991)). The set of atomic coordinates of Pin1 R14A as determined by X-ray crystallography is provided as Table 1.

TABLE 1
Set of atomic coordinates of Pin1 R14A as determined by X-ray crystallography
ATOM	1	CB	LYS		6	26.317	49.386	−27.408	1.00	75.75	C
ATOM	2	CG	LYS		6	25.999	49.158	−25.938	1.00	76.44	C
ATOM	3	CD	LYS		6	26.255	50.416	−25.125	1.00	77.48	C
ATOM	4	CE	LYS		6	25.985	50.186	−23.650	1.00	77.75	C
ATOM	5	NZ	LYS		6	26.269	51.405	−22.845	1.00	78.45	N
ATOM	6	C	LYS		6	24.620	47.817	−28.371	1.00	74.39	C
ATOM	7	O	LYS		6	23.834	48.207	−27.507	1.00	74.98	O
ATOM	8	N	LYS		6	26.644	48.422	−29.663	1.00	75.06	N
ATOM	9	CA	LYS		6	26.106	48.159	−28.298	1.00	75.05	C
ATOM	10	N	LEU		7	24.249	47.086	−29.418	1.00	73.33	N
ATOM	11	CA	LEU		7	22.871	46.659	−29.644	1.00	71.57	C
ATOM	12	CB	LEU		7	22.295	46.010	−28.379	1.00	71.92	C
ATOM	13	CG	LEU		7	22.952	44.689	−27.979	1.00	71.84	C
ATOM	14	CD1	LEU		7	22.289	44.121	−26.733	1.00	71.98	C
ATOM	15	CD2	LEU		7	22.841	43.718	−29.142	1.00	71.81	C
ATOM	16	C	LEU		7	21.935	47.763	−30.123	1.00	69.78	C
ATOM	17	O	LEU		7	21.756	48.780	−29.454	1.00	69.52	O
ATOM	18	N	PRO		8	21.327	47.567	−31.303	1.00	68.04	N
ATOM	19	CD	PRO		8	21.626	46.449	−32.214	1.00	67.76	C
ATOM	20	CA	PRO		8	20.391	48.502	−31.933	1.00	66.26	C
ATOM	21	CB	PRO		8	20.024	47.787	−33.233	1.00	66.72	C
ATOM	22	CG	PRO		8	21.263	47.031	−33.555	1.00	67.32	C
ATOM	23	C	PRO		8	19.169	48.756	−31.045	1.00	64.59	C
ATOM	24	O	PRO		8	19.171	48.411	−29.861	1.00	64.16	O
ATOM	25	N	PRO		9	18.114	49.374	−31.605	1.00	62.73	N
ATOM	26	CD	PRO		9	18.120	50.167	−32.846	1.00	63.09	C
ATOM	27	CA	PRO		9	16.901	49.656	−30.830	1.00	59.43	C
ATOM	28	CB	PRO		9	16.207	50.746	−31.652	1.00	61.30	C
ATOM	29	CG	PRO		9	17.323	51.369	−32.440	1.00	63.30	C
ATOM	30	C	PRO		9	15.999	48.438	−30.656	1.00	54.44	C
ATOM	31	O	PRO		9	15.606	47.803	−31.636	1.00	54.75	O
ATOM	32	N	GLY		10	15.673	48.114	−29.408	1.00	48.14	N
ATOM	33	CA	GLY		10	14.791	46.987	−29.158	1.00	41.85	C
ATOM	34	C	GLY		10	15.451	45.633	−28.957	1.00	36.53	C
ATOM	35	O	GLY		10	14.763	44.648	−28.689	1.00	33.03	O
ATOM	36	N	TRP		11	16.773	45.579	−29.077	1.00	34.92	N
ATOM	37	CA	TRP		11	17.505	44.327	−28.904	1.00	33.37	C
ATOM	38	CB	TRP		11	18.664	44.241	−29.898	1.00	31.56	C
ATOM	39	CG	TRP		11	18.240	43.993	−31.302	1.00	30.03	C
ATOM	40	CD2	TRP		11	17.911	42.727	−31.885	1.00	29.07	C
ATOM	41	CE2	TRP		11	17.564	42.967	−33.235	1.00	28.10	C
ATOM	42	CE3	TRP		11	17.875	41.411	−31.399	1.00	26.09	C
ATOM	43	CD1	TRP		11	18.082	44.923	−32.292	1.00	30.05	C
ATOM	44	NE1	TRP		11	17.678	44.315	−33.453	1.00	29.35	N
ATOM	45	CZ2	TRP		11	17.187	41.941	−34.105	1.00	26.58	C
ATOM	46	CZ3	TRP		11	17.500	40.391	−32.264	1.00	25.29	C
ATOM	47	CH2	TRP		11	17.161	40.663	−33.604	1.00	26.24	C
ATOM	48	C	TRP		11	18.060	44.130	−27.499	1.00	33.25	C
ATOM	49	O	TRP		11	18.412	45.089	−26.811	1.00	32.43	O
ATOM	50	N	GLU		12	18.137	42.871	−27.078	1.00	31.52	N
ATOM	51	CA	GLU		12	18.677	42.542	−25.769	1.00	30.58	C
ATOM	52	CB	GLU		12	17.559	42.419	−24.734	1.00	30.62	C
ATOM	53	CG	GLU		12	16.673	41.201	−24.889	1.00	32.61	C
ATOM	54	CD	GLU		12	15.547	41.189	−23.878	1.00	34.53	C
ATOM	55	OE1	GLU		12	14.612	42.008	−24.013	1.00	33.83	O
ATOM	56	OE2	GLU		12	15.606	40.372	−22.937	1.00	34.83	O
ATOM	57	C	GLU		12	19.437	41.229	−25.880	1.00	29.52	C
ATOM	58	O	GLU		12	19.170	40.417	−26.768	1.00	27.64	O
ATOM	59	N	LYS		13	20.392	41.031	−24.985	1.00	28.84	N
ATOM	60	CA	LYS		13	21.183	39.811	−24.993	1.00	30.55	C
ATOM	61	CB	LYS		13	22.525	40.053	−24.299	1.00	32.86	C
ATOM	62	CG	LYS		13	23.505	38.895	−24.393	1.00	36.09	C
ATOM	63	CD	LYS		13	24.783	39.201	−23.614	1.00	38.49	C
ATOM	64	CE	LYS		13	25.499	40.428	−24.175	1.00	39.37	C
ATOM	65	NZ	LYS		13	26.694	40.807	−23.364	1.00	40.68	N
ATOM	66	C	LYS		13	20.394	38.745	−24.257	1.00	30.06	C
ATOM	67	O	LYS		13	19.679	39.040	−23.294	1.00	28.85	O
ATOM	68	N	ALA		14	20.510	37.504	−24.714	1.00	29.08	N
ATOM	69	CA	ALA		14	19.798	36.413	−24.073	1.00	29.26	C
ATOM	70	CB	ALA		14	18.550	36.049	−24.882	1.00	29.89	C
ATOM	71	C	ALA		14	20.705	35.199	−23.915	1.00	28.49	C
ATOM	72	O	ALA		14	21.813	35.161	−24.448	1.00	26.85	O
ATOM	73	N	MET		15	20.220	34.208	−23.183	1.00	29.72	N
ATOM	74	CA	MET		15	20.984	32.995	−22.943	1.00	29.88	C
ATOM	75	CB	MET		15	21.318	32.895	−21.456	1.00	33.30	C
ATOM	76	CG	MET		15	22.022	31.619	−21.070	1.00	36.15	C
ATOM	77	SD	MET		15	23.597	31.529	−21.892	1.00	39.84	S
ATOM	78	CE	MET		15	24.542	32.702	−20.899	1.00	37.57	C
ATOM	79	C	MET		15	20.180	31.775	−23.362	1.00	29.22	C
ATOM	80	O	MET		15	19.071	31.573	−22.883	1.00	27.04	O
ATOM	81	N	SER		16	20.738	30.963	−24.254	1.00	28.77	N
ATOM	82	CA	SER		16	20.048	29.757	−24.693	1.00	28.24	C
ATOM	83	CB	SER		16	20.804	29.085	−25.834	1.00	28.93	C
ATOM	84	OG	SER		16	20.279	27.788	−26.061	1.00	30.01	O
ATOM	85	C	SER		16	19.932	28.776	−23.532	1.00	28.89	C
ATOM	86	O	SER		16	20.932	28.418	−22.910	1.00	27.90	O
ATOM	87	N	ARG		17	18.706	28.352	−23.244	1.00	29.91	N
ATOM	88	CA	ARG		17	18.444	27.403	−22.166	1.00	32.62	C
ATOM	89	CB	ARG		17	16.939	27.317	−21.895	1.00	34.74	C
ATOM	90	CG	ARG		17	16.323	28.597	−21.357	1.00	37.67	C
ATOM	91	CD	ARG		17	16.886	28.960	−19.994	1.00	38.10	C
ATOM	92	NE	ARG		17	16.386	30.253	−19.533	1.00	40.92	N
ATOM	93	CZ	ARG		17	15.132	30.484	−19.153	1.00	41.40	C
ATOM	94	NH1	ARG		17	14.235	29.508	−19.167	1.00	41.19	N
ATOM	95	NH2	ARG		17	14.773	31.700	−18.769	1.00	41.62	N
ATOM	96	C	ARG		17	18.963	26.011	−22.511	1.00	33.46	C
ATOM	97	O	ARG		17	19.246	25.207	−21.621	1.00	32.53	O
ATOM	98	N	SER		18	19.086	25.730	−23.804	1.00	34.96	N
ATOM	99	CA	SER		18	19.552	24.424	−24.259	1.00	37.48	C
ATOM	100	CB	SER		18	18.902	24.070	−25.599	1.00	38.32	C
ATOM	101	OG	SER		18	17.506	23.886	−25.458	1.00	43.49	O
ATOM	102	C	SER		18	21.061	24.307	−24.404	1.00	37.45	C
ATOM	103	O	SER		18	21.662	23.349	−23.920	1.00	40.02	O
ATOM	104	N	SER		19	21.669	25.286	−25.066	1.00	36.22	N
ATOM	105	CA	SER		19	23.102	25.271	−25.311	1.00	35.77	C
ATOM	106	CB	SER		19	23.377	25.684	−26.759	1.00	38.18	C
ATOM	107	OG	SER		19	22.862	26.978	−27.025	1.00	39.68	O
ATOM	108	C	SER		19	23.938	26.137	−24.386	1.00	35.38	C
ATOM	109	O	SER		19	25.120	25.870	−24.188	1.00	35.14	O
ATOM	110	N	GLY		20	23.332	27.177	−23.825	1.00	35.10	N
ATOM	111	CA	GLY		20	24.074	28.060	−22.947	1.00	33.07	C
ATOM	112	C	GLY		20	24.807	29.116	−23.756	1.00	31.89	C
ATOM	113	O	GLY		20	25.558	29.923	−23.215	1.00	31.35	O
ATOM	114	N	ARG		21	24.590	29.112	−25.064	1.00	30.69	N
ATOM	115	CA	ARG		21	25.241	30.083	−25.929	1.00	30.10	C
ATOM	116	CB	ARG		21	25.371	29.524	−27.343	1.00	33.05	C
ATOM	117	CG	ARG		21	26.334	30.296	−28.229	1.00	37.69	C
ATOM	118	CD	ARG		21	26.025	30.027	−29.687	1.00	40.08	C
ATOM	119	NE	ARG		21	25.742	28.615	−29.899	1.00	40.15	N
ATOM	120	CZ	ARG		21	25.137	28.125	−30.973	1.00	40.11	C
ATOM	121	NH1	ARG		21	24.745	28.932	−31.951	1.00	38.33	N
ATOM	122	NH2	ARG		21	24.915	26.821	−31.059	1.00	42.15	N
ATOM	123	C	ARG		21	24.403	31.360	−25.966	1.00	27.27	C
ATOM	124	O	ARG		21	23.173	31.308	−25.940	1.00	24.40	O
ATOM	125	N	VAL		22	25.071	32.502	−26.033	1.00	26.38	N
ATOM	126	CA	VAL		22	24.364	33.773	−26.072	1.00	25.85	C
ATOM	127	CB	VAL		22	25.328	34.963	−25.832	1.00	28.19	C
ATOM	128	CG1	VAL		22	26.054	34.787	−24.507	1.00	31.21	C
ATOM	129	CG2	VAL		22	26.329	35.067	−26.972	1.00	29.97	C
ATOM	130	C	VAL		22	23.679	33.968	−27.422	1.00	23.85	C
ATOM	131	O	VAL		22	24.131	33.456	−28.443	1.00	22.20	O
ATOM	132	N	TYR		23	22.563	34.684	−27.415	1.00	23.69	N
ATOM	133	CA	TYR		23	21.856	34.991	−28.649	1.00	22.30	C
ATOM	134	CB	TYR		23	20.838	33.901	−29.014	1.00	22.14	C
ATOM	135	CG	TYR		23	19.604	33.801	−28.143	1.00	23.90	C
ATOM	136	CD1	TYR		23	18.394	34.384	−28.536	1.00	24.48	C
ATOM	137	CE1	TYR		23	17.236	34.223	−27.777	1.00	23.42	C
ATOM	138	CD2	TYR		23	19.624	33.062	−26.960	1.00	25.02	C
ATOM	139	CE2	TYR		23	18.478	32.896	−26.196	1.00	27.09	C
ATOM	140	CZ	TYR		23	17.286	33.475	−26.610	1.00	26.36	C
ATOM	141	OH	TYR		23	16.151	33.282	−25.852	1.00	26.92	O
ATOM	142	C	TYR		23	21.179	36.322	−28.409	1.00	22.90	C
ATOM	143	O	TYR		23	21.224	36.850	−27.298	1.00	22.70	O
ATOM	144	N	TYR		24	20.561	36.873	−29.441	1.00	23.42	N
ATOM	145	CA	TYR		24	19.916	38.161	−29.289	1.00	23.78	C
ATOM	146	CB	TYR		24	20.641	39.189	−30.156	1.00	26.76	C
ATOM	147	CG	TYR		24	22.094	39.296	−29.751	1.00	31.08	C
ATOM	148	CD1	TYR		24	23.035	38.359	−30.191	1.00	33.27	C
ATOM	149	CE1	TYR		24	24.353	38.387	−29.729	1.00	34.88	C
ATOM	150	CD2	TYR		24	22.512	40.269	−28.843	1.00	33.85	C
ATOM	151	CE2	TYR		24	23.825	40.308	−28.375	1.00	34.75	C
ATOM	152	CZ	TYR		24	24.740	39.366	−28.820	1.00	36.76	C
ATOM	153	OH	TYR		24	26.037	39.402	−28.354	1.00	38.29	O
ATOM	154	C	TYR		24	18.431	38.094	−29.588	1.00	23.08	C
ATOM	155	O	TYR		24	17.989	37.360	−30.466	1.00	21.07	O
ATOM	156	N	PHE		25	17.668	38.857	−28.821	1.00	23.04	N
ATOM	157	CA	PHE		25	16.224	38.887	−28.942	1.00	23.59	C
ATOM	158	CB	PHE		25	15.625	38.214	−27.706	1.00	23.65	C
ATOM	159	CG	PHE		25	14.153	38.413	−27.550	1.00	24.29	C
ATOM	160	CD1	PHE		25	13.252	37.731	−28.360	1.00	24.38	C
ATOM	161	CD2	PHE		25	13.663	39.279	−26.575	1.00	24.35	C
ATOM	162	CE1	PHE		25	11.874	37.910	−28.200	1.00	23.65	C
ATOM	163	CE2	PHE		25	12.296	39.464	−26.409	1.00	24.27	C
ATOM	164	CZ	PHE		25	11.400	38.776	−27.225	1.00	24.79	C
ATOM	165	C	PHE		25	15.756	40.333	−29.055	1.00	24.00	C
ATOM	166	O	PHE		25	16.287	41.219	−28.386	1.00	24.15	O
ATOM	167	N	ASN		26	14.773	40.564	−29.921	1.00	23.32	N
ATOM	168	CA	ASN		26	14.215	41.900	−30.122	1.00	23.05	C
ATOM	169	CB	ASN		26	14.169	42.231	−31.621	1.00	22.84	C
ATOM	170	CG	ASN		26	13.816	43.686	−31.889	1.00	20.90	C
ATOM	171	OD1	ASN		26	12.734	44.146	−31.542	1.00	20.54	O
ATOM	172	ND2	ASN		26	14.734	44.412	−32.511	1.00	21.46	N
ATOM	173	C	ASN		26	12.810	41.891	−29.536	1.00	20.66	C
ATOM	174	O	ASN		26	11.950	41.139	−29.986	1.00	20.34	O
ATOM	175	N	HIS		27	12.572	42.725	−28.528	1.00	21.02	N
ATOM	176	CA	HIS		27	11.266	42.747	−27.880	1.00	20.66	C
ATOM	177	CB	HIS		27	11.398	43.280	−26.442	1.00	20.66	C
ATOM	178	CG	HIS		27	11.962	44.665	−26.348	1.00	23.34	C
ATOM	179	CD2	HIS		27	13.198	45.103	−26.012	1.00	23.87	C
ATOM	180	ND1	HIS		27	11.211	45.795	−26.597	1.00	25.84	N
ATOM	181	CE1	HIS		27	11.959	46.868	−26.416	1.00	25.11	C
ATOM	182	NE2	HIS		27	13.170	46.476	−26.062	1.00	27.78	N
ATOM	183	C	HIS		27	10.170	43.498	−28.637	1.00	20.96	C
ATOM	184	O	HIS		27	9.031	43.556	−28.187	1.00	21.38	O
ATOM	185	N	ILE		28	10.507	44.063	−29.786	1.00	22.76	N
ATOM	186	CA	ILE		28	9.506	44.769	−30.579	1.00	23.22	C
ATOM	187	CB	ILE		28	10.077	46.083	−31.149	1.00	23.38	C
ATOM	188	CG2	ILE		28	9.017	46.788	−31.990	1.00	22.95	C
ATOM	189	CG1	ILE		28	10.515	46.990	−29.993	1.00	23.21	C
ATOM	190	CD1	ILE		28	11.319	48.213	−30.425	1.00	24.17	C
ATOM	191	C	ILE		28	9.011	43.872	−31.720	1.00	22.19	C
ATOM	192	O	ILE		28	7.810	43.823	−32.001	1.00	22.10	O
ATOM	193	N	THR		29	9.931	43.138	−32.347	1.00	21.09	N
ATOM	194	CA	THR		29	9.582	42.237	−33.452	1.00	21.14	C
ATOM	195	CB	THR		29	10.655	42.249	−34.551	1.00	21.56	C
ATOM	196	OG1	THR		29	11.887	41.750	−34.008	1.00	18.52	O
ATOM	197	CG2	THR		29	10.877	43.657	−35.075	1.00	21.14	C
ATOM	198	C	THR		29	9.454	40.785	−33.002	1.00	21.23	C
ATOM	199	O	THR		29	8.899	39.949	−33.725	1.00	19.43	O
ATOM	200	N	ASN		30	9.977	40.499	−31.810	1.00	21.08	N
ATOM	201	CA	ASN		30	9.985	39.155	−31.243	1.00	20.34	C
ATOM	202	CB	ASN		30	8.563	38.590	−31.168	1.00	20.23	C
ATOM	203	CG	ASN		30	7.787	39.129	−29.968	1.00	20.49	C
ATOM	204	OD1	ASN		30	6.559	39.252	−29.999	1.00	20.76	O
ATOM	205	ND2	ASN		30	8.508	39.444	−28.905	1.00	19.52	N
ATOM	206	C	ASN		30	10.913	38.229	−32.037	1.00	20.74	C
ATOM	207	O	ASN		30	10.803	37.001	−31.975	1.00	20.80	O
ATOM	208	N	ALA		31	11.836	38.824	−32.785	1.00	19.68	N
ATOM	209	CA	ALA		31	12.798	38.032	−33.548	1.00	20.16	C
ATOM	210	CB	ALA		31	13.345	38.841	−34.720	1.00	19.74	C
ATOM	211	C	ALA		31	13.947	37.605	−32.637	1.00	20.68	C
ATOM	212	O	ALA		31	14.253	38.270	−31.646	1.00	18.54	O
ATOM	213	N	SER		32	14.566	36.477	−32.969	1.00	19.88	N
ATOM	214	CA	SER		32	15.709	35.983	−32.220	1.00	21.20	C
ATOM	215	CB	SER		32	15.278	34.911	−31.207	1.00	19.65	C
ATOM	216	OG	SER		32	14.486	33.901	−31.803	1.00	25.48	O
ATOM	217	C	SER		32	16.716	35.433	−33.236	1.00	22.14	C
ATOM	218	O	SER		32	16.332	34.801	−34.219	1.00	21.52	O
ATOM	219	N	GLN		33	17.999	35.702	−33.004	1.00	22.52	N
ATOM	220	CA	GLN		33	19.072	35.271	−33.902	1.00	23.90	C
ATOM	221	CB	GLN		33	19.341	36.356	−34.951	1.00	25.32	C
ATOM	222	CG	GLN		33	19.529	37.743	−34.344	1.00	28.58	C
ATOM	223	CD	GLN		33	19.893	38.811	−35.367	1.00	32.66	C
ATOM	224	OE1	GLN		33	21.068	39.118	−35.572	1.00	36.83	O
ATOM	225	NE2	GLN		33	18.886	39.375	−36.016	1.00	29.57	N
ATOM	226	C	GLN		33	20.347	35.036	−33.094	1.00	24.47	C
ATOM	227	O	GLN		33	20.493	35.574	−31.999	1.00	23.29	O
ATOM	228	N	TRP		34	21.276	34.254	−33.644	1.00	25.01	N
ATOM	229	CA	TRP		34	22.531	33.973	−32.948	1.00	25.47	C
ATOM	230	CB	TRP		34	23.213	32.726	−33.537	1.00	23.87	C
ATOM	231	CG	TRP		34	22.521	31.438	−33.188	1.00	21.81	C
ATOM	232	CD2	TRP		34	22.341	30.889	−31.877	1.00	22.45	C
ATOM	233	CE2	TRP		34	21.590	29.702	−32.021	1.00	22.25	C
ATOM	234	CE3	TRP		34	22.742	31.286	−30.594	1.00	22.29	C
ATOM	235	CD1	TRP		34	21.896	30.582	−34.049	1.00	21.58	C
ATOM	236	NE1	TRP		34	21.333	29.540	−33.357	1.00	21.07	N
ATOM	237	CZ2	TRP		34	21.228	28.906	−30.929	1.00	23.45	C
ATOM	238	CZ3	TRP		34	22.386	30.493	−29.508	1.00	23.48	C
ATOM	239	CH2	TRP		34	21.635	29.317	−29.683	1.00	23.38	C
ATOM	240	C	TRP		34	23.518	35.140	−32.965	1.00	27.36	C
ATOM	241	O	TRP		34	24.168	35.417	−31.954	1.00	26.42	O
ATOM	242	N	GLU		35	23.624	35.827	−34.103	1.00	28.79	N
ATOM	243	CA	GLU		35	24.558	36.938	−34.228	1.00	32.29	C
ATOM	244	CB	GLU		35	24.885	37.205	−35.694	1.00	32.69	C
ATOM	245	CG	GLU		35	25.387	36.002	−36.457	1.00	33.59	C
ATOM	246	CD	GLU		35	26.098	36.391	−37.735	1.00	34.42	C
ATOM	247	OE1	GLU		35	26.165	35.550	−38.653	1.00	34.44	O
ATOM	248	OE2	GLU		35	26.607	37.534	−37.815	1.00	33.46	O
ATOM	249	C	GLU		35	24.084	38.238	−33.604	1.00	36.01	C
ATOM	250	O	GLU		35	22.887	38.518	−33.549	1.00	34.67	O
ATOM	251	N	ARG		36	25.043	39.033	−33.142	1.00	39.87	N
ATOM	252	CA	ARG		36	24.739	40.319	−32.539	1.00	45.62	C
ATOM	253	CB	ARG		36	25.973	40.886	−31.837	1.00	47.70	C
ATOM	254	CG	ARG		36	25.677	42.099	−30.977	1.00	52.10	C
ATOM	255	CD	ARG		36	26.885	42.506	−30.154	1.00	55.23	C
ATOM	256	NE	ARG		36	26.518	43.444	−29.099	1.00	57.97	N
ATOM	257	CZ	ARG		36	27.353	43.885	−28.166	1.00	59.67	C
ATOM	258	NH1	ARG		36	28.615	43.475	−28.155	1.00	60.43	N
ATOM	259	NH2	ARG		36	26.924	44.730	−27.238	1.00	60.07	N
ATOM	260	C	ARG		36	24.325	41.219	−33.693	1.00	47.90	C
ATOM	261	O	ARG		36	25.099	41.438	−34.625	1.00	48.07	O
ATOM	262	N	PRO		37	23.094	41.746	−33.647	1.00	49.97	N
ATOM	263	CD	PRO		37	22.208	41.730	−32.471	1.00	50.02	C
ATOM	264	CA	PRO		37	22.547	42.624	−34.685	1.00	52.82	C
ATOM	265	CB	PRO		37	21.156	42.947	−34.153	1.00	51.49	C
ATOM	266	CG	PRO		37	21.381	42.976	−32.682	1.00	50.64	C
ATOM	267	C	PRO		37	23.367	43.882	−34.952	1.00	55.66	C
ATOM	268	O	PRO		37	23.945	44.467	−34.034	1.00	55.81	O
ATOM	269	N	SER		38	23.403	44.284	−36.220	1.00	58.07	N
ATOM	270	CA	SER		38	24.126	45.474	−36.658	1.00	60.06	C
ATOM	271	CB	SER		38	23.196	46.689	−36.607	1.00	59.17	C
ATOM	272	OG	SER		38	22.011	46.444	−37.347	1.00	57.19	O
ATOM	273	C	SER		38	25.377	45.750	−35.831	1.00	61.25	C
ATOM	274	O	SER		38	25.633	46.888	−35.437	1.00	62.84	O
ATOM	275	N	GLU		51	14.438	56.608	−39.353	1.00	57.69	N
ATOM	276	CA	GLU		51	13.791	55.417	−39.887	1.00	57.34	C
ATOM	277	CB	GLU		51	12.787	54.856	−38.872	1.00	57.35	C
ATOM	278	CG	GLU		51	11.476	55.629	−38.793	1.00	56.42	C
ATOM	279	CD	GLU		51	10.543	55.101	−37.718	1.00	56.15	C
ATOM	280	OE1	GLU		51	9.364	55.509	−37.704	1.00	55.24	O
ATOM	281	OE2	GLU		51	10.987	54.285	−36.884	1.00	56.66	O
ATOM	282	C	GLU		51	13.066	55.776	−41.180	1.00	56.81	C
ATOM	283	O	GLU		51	12.765	56.944	−41.425	1.00	57.20	O
ATOM	284	N	PRO		52	12.776	54.774	−42.026	1.00	55.89	N
ATOM	285	CD	PRO		52	13.163	53.358	−41.904	1.00	55.54	C
ATOM	286	CA	PRO		52	12.081	55.013	−43.294	1.00	54.05	C
ATOM	287	CB	PRO		52	11.985	53.617	−43.903	1.00	54.81	C
ATOM	288	CG	PRO		52	13.186	52.919	−43.344	1.00	55.46	C
ATOM	289	C	PRO		52	10.706	55.626	−43.066	1.00	52.40	C
ATOM	290	O	PRO		52	10.054	55.342	−42.064	1.00	53.30	O
ATOM	291	N	ALA		53	10.269	56.467	−43.995	1.00	50.01	N
ATOM	292	CA	ALA		53	8.962	57.096	−43.882	1.00	47.50	C
ATOM	293	CB	ALA		53	8.839	58.233	−44.888	1.00	47.78	C
ATOM	294	C	ALA		53	7.902	56.037	−44.151	1.00	45.45	C
ATOM	295	O	ALA		53	6.777	56.115	−43.654	1.00	44.38	O
ATOM	296	N	ARG		54	8.277	55.044	−44.949	1.00	43.10	N
ATOM	297	CA	ARG		54	7.380	53.954	−45.301	1.00	39.82	C
ATOM	298	CB	ARG		54	6.669	54.259	−46.623	1.00	42.74	C
ATOM	299	CG	ARG		54	5.840	55.532	−46.615	1.00	46.81	C
ATOM	300	CD	ARG		54	5.537	56.006	−48.032	1.00	49.87	C
ATOM	301	NE	ARG		54	4.699	55.078	−48.790	1.00	51.01	N
ATOM	302	CZ	ARG		54	3.428	54.811	−48.507	1.00	52.78	C
ATOM	303	NH1	ARG		54	2.834	55.398	−47.476	1.00	53.46	N
ATOM	304	NH2	ARG		54	2.743	53.965	−49.266	1.00	53.28	N
ATOM	305	C	ARG		54	8.171	52.661	−45.450	1.00	35.96	C
ATOM	306	O	ARG		54	9.373	52.676	−45.712	1.00	35.46	O
ATOM	307	N	VAL		55	7.489	51.540	−45.266	1.00	32.57	N
ATOM	308	CA	VAL		55	8.110	50.235	−45.429	1.00	28.54	C
ATOM	309	CB	VAL		55	8.445	49.557	−44.071	1.00	27.23	C
ATOM	310	CG1	VAL		55	9.463	50.390	−43.307	1.00	24.86	C
ATOM	311	CG2	VAL		55	7.170	49.373	−43.251	1.00	24.27	C
ATOM	312	C	VAL		55	7.094	49.373	−46.149	1.00	27.45	C
ATOM	313	O	VAL		55	5.902	49.681	−46.163	1.00	26.43	O
ATOM	314	N	ARG		56	7.571	48.301	−46.764	1.00	25.29	N
ATOM	315	CA	ARG		56	6.687	47.379	−47.449	1.00	23.95	C
ATOM	316	CB	ARG		56	7.073	47.251	−48.924	1.00	23.09	C
ATOM	317	CG	ARG		56	6.146	46.336	−49.702	1.00	24.25	C
ATOM	318	CD	ARG		56	6.558	46.212	−51.166	1.00	25.63	C
ATOM	319	NE	ARG		56	5.648	45.336	−51.900	1.00	26.11	N
ATOM	320	CZ	ARG		56	5.716	45.108	−53.210	1.00	27.42	C
ATOM	321	NH1	ARG		56	6.656	45.691	−53.944	1.00	25.82	N
ATOM	322	NH2	ARG		56	4.841	44.297	−53.789	1.00	26.73	N
ATOM	323	C	ARG		56	6.852	46.041	−46.742	1.00	22.60	C
ATOM	324	O	ARG		56	7.973	45.599	−46.497	1.00	22.92	O
ATOM	325	N	CYS		57	5.740	45.405	−46.401	1.00	22.50	N
ATOM	326	CA	CYS		57	5.797	44.124	−45.715	1.00	21.96	C
ATOM	327	CB	CYS		57	5.526	44.299	−44.216	1.00	21.34	C
ATOM	328	SG	CYS		57	6.684	45.319	−43.331	1.00	20.11	S
ATOM	329	C	CYS		57	4.773	43.148	−46.240	1.00	22.55	C
ATOM	330	O	CYS		57	3.781	43.534	−46.871	1.00	22.64	O
ATOM	331	N	SER		58	5.037	41.875	−45.972	1.00	20.32	N
ATOM	332	CA	SER		58	4.123	40.796	−46.298	1.00	20.21	C
ATOM	333	CB	SER		58	4.763	39.753	−47.217	1.00	20.04	C
ATOM	334	OG	SER		58	5.040	40.301	−48.486	1.00	19.12	O
ATOM	335	C	SER		58	3.893	40.179	−44.932	1.00	20.61	C
ATOM	336	O	SER		58	4.712	40.362	−44.019	1.00	20.53	O
ATOM	337	N	HIS		59	2.788	39.462	−44.770	1.00	20.02	N
ATOM	338	CA	HIS		59	2.544	38.821	−43.499	1.00	19.93	C
ATOM	339	CB	HIS		59	1.860	39.802	−42.515	1.00	21.80	C
ATOM	340	CG	HIS		59	0.362	39.853	−42.617	1.00	24.62	C
ATOM	341	CD2	HIS		59	−0.592	39.810	−41.657	1.00	22.95	C
ATOM	342	ND1	HIS		59	−0.307	40.000	−43.813	1.00	24.31	N
ATOM	343	CE1	HIS		59	−1.609	40.041	−43.586	1.00	21.97	C
ATOM	344	NE2	HIS		59	−1.809	39.930	−42.286	1.00	26.77	N
ATOM	345	C	HIS		59	1.735	37.555	−43.672	1.00	20.16	C
ATOM	346	O	HIS		59	1.118	37.315	−44.720	1.00	18.78	O
ATOM	347	N	LEU		60	1.789	36.720	−42.647	1.00	18.36	N
ATOM	348	CA	LEU		60	1.043	35.482	−42.616	1.00	19.49	C
ATOM	349	CB	LEU		60	1.976	34.278	−42.576	1.00	18.97	C
ATOM	350	CG	LEU		60	1.345	32.883	−42.703	1.00	18.12	C
ATOM	351	CD1	LEU		60	2.445	31.884	−43.007	1.00	18.41	C
ATOM	352	CD2	LEU		60	0.605	32.495	−41.431	1.00	17.46	C
ATOM	353	C	LEU		60	0.293	35.625	−41.305	1.00	20.43	C
ATOM	354	O	LEU		60	0.894	35.803	−40.240	1.00	19.13	O
ATOM	355	N	LEU		61	−1.026	35.592	−41.391	1.00	20.07	N
ATOM	356	CA	LEU		61	−1.850	35.751	−40.210	1.00	21.15	C
ATOM	357	CB	LEU		61	−2.889	36.849	−40.457	1.00	22.48	C
ATOM	358	CG	LEU		61	−4.014	37.017	−39.429	1.00	22.65	C
ATOM	359	CD1	LEU		61	−3.441	37.533	−38.115	1.00	24.95	C
ATOM	360	CD2	LEU		61	−5.060	37.990	−39.972	1.00	24.74	C
ATOM	361	C	LEU		61	−2.556	34.460	−39.843	1.00	20.90	C
ATOM	362	O	LEU		61	−3.067	33.749	−40.705	1.00	18.95	O
ATOM	363	N	VAL		62	−2.557	34.147	−38.554	1.00	20.75	N
ATOM	364	CA	VAL		62	−3.261	32.978	−38.075	1.00	20.88	C
ATOM	365	CB	VAL		62	−2.324	31.949	−37.415	1.00	21.62	C
ATOM	366	CG1	VAL		62	−3.155	30.825	−36.786	1.00	21.94	C
ATOM	367	CG2	VAL		62	−1.382	31.361	−38.461	1.00	22.40	C
ATOM	368	C	VAL		62	−4.234	33.540	−37.047	1.00	21.88	C
ATOM	369	O	VAL		62	−3.827	34.113	−36.037	1.00	19.51	O
ATOM	370	N	LYS		63	−5.523	33.411	−37.334	1.00	22.77	N
ATOM	371	CA	LYS		63	−6.543	33.923	−36.434	1.00	25.20	C
ATOM	372	CB	LYS		63	−7.782	34.376	−37.218	1.00	26.39	C
ATOM	373	CG	LYS		63	−7.604	35.675	−37.987	1.00	28.45	C
ATOM	374	CD	LYS		63	−8.925	36.124	−38.611	1.00	29.09	C
ATOM	375	CE	LYS		63	−8.822	37.513	−39.201	1.00	27.74	C
ATOM	376	NZ	LYS		63	−10.093	37.921	−39.861	1.00	28.12	N
ATOM	377	C	LYS		63	−6.950	32.873	−35.415	1.00	25.23	C
ATOM	378	O	LYS		63	−6.698	31.681	−35.591	1.00	24.50	O
ATOM	379	N	HIS		64	−7.573	33.335	−34.339	1.00	26.37	N
ATOM	380	CA	HIS		64	−8.046	32.449	−33.288	1.00	26.91	C
ATOM	381	CB	HIS		64	−7.077	32.470	−32.098	1.00	24.05	C
ATOM	382	CG	HIS		64	−6.700	33.845	−31.646	1.00	25.82	C
ATOM	383	CD2	HIS		64	−5.538	34.531	−31.753	1.00	26.61	C
ATOM	384	ND1	HIS		64	−7.584	34.688	−31.005	1.00	25.59	N
ATOM	385	CE1	HIS		64	−6.982	35.832	−30.738	1.00	28.49	C
ATOM	386	NE2	HIS		64	−5.739	35.763	−31.182	1.00	27.26	N
ATOM	387	C	HIS		64	−9.448	32.903	−32.882	1.00	27.07	C
ATOM	388	O	HIS		64	−9.980	33.858	−33.446	1.00	26.03	O
ATOM	389	N	SER		65	−10.044	32.223	−31.910	1.00	30.47	N
ATOM	390	CA	SER		65	−11.395	32.555	−31.472	1.00	30.56	C
ATOM	391	CB	SER		65	−11.891	31.508	−30.473	1.00	33.30	C
ATOM	392	OG	SER		65	−11.143	31.559	−29.272	1.00	34.85	O
ATOM	393	C	SER		65	−11.551	33.952	−30.868	1.00	31.48	C
ATOM	394	O	SER		65	−12.665	34.473	−30.796	1.00	30.78	O
ATOM	395	N	GLN		66	−10.455	34.564	−30.430	1.00	29.16	N
ATOM	396	CA	GLN		66	−10.554	35.901	−29.846	1.00	29.95	C
ATOM	397	CB	GLN		66	−9.703	36.005	−28.567	1.00	30.78	C
ATOM	398	CG	GLN		66	−10.244	35.180	−27.394	1.00	31.19	C
ATOM	399	CD	GLN		66	−9.508	35.439	−26.078	1.00	34.58	C
ATOM	400	OE1	GLN		66	−9.476	36.568	−25.577	1.00	32.21	O
ATOM	401	NE2	GLN		66	−8.921	34.388	−25.512	1.00	34.03	N
ATOM	402	C	GLN		66	−10.192	37.025	−30.814	1.00	29.66	C
ATOM	403	O	GLN		66	−10.088	38.187	−30.414	1.00	32.44	O
ATOM	404	N	SER		67	−10.002	36.688	−32.087	1.00	30.14	N
ATOM	405	CA	SER		67	−9.676	37.694	−33.096	1.00	31.52	C
ATOM	406	CB	SER		67	−9.325	37.024	−34.432	1.00	29.84	C
ATOM	407	OG	SER		67	−8.112	36.294	−34.338	1.00	26.70	O
ATOM	408	C	SER		67	−10.902	38.585	−33.271	1.00	33.64	C
ATOM	409	O	SER		67	−12.031	38.094	−33.203	1.00	33.54	O
ATOM	410	N	ARG		68	−10.687	39.880	−33.499	1.00	36.87	N
ATOM	411	CA	ARG		68	−11.808	40.805	−33.658	1.00	41.36	C
ATOM	412	CB	ARG		68	−11.325	42.189	−34.103	1.00	45.22	C
ATOM	413	CG	ARG		68	−10.498	42.197	−35.362	1.00	52.20	C
ATOM	414	CD	ARG		68	−10.198	43.620	−35.816	1.00	57.28	C
ATOM	415	NE	ARG		68	−9.482	44.391	−34.805	1.00	61.00	N
ATOM	416	CZ	ARG		68	−8.980	45.604	−35.011	1.00	63.18	C
ATOM	417	NH1	ARG		68	−9.112	46.186	−36.197	1.00	63.39	N
ATOM	418	NH2	ARG		68	−8.347	46.238	−34.032	1.00	64.64	N
ATOM	419	C	ARG		68	−12.832	40.252	−34.641	1.00	41.19	C
ATOM	420	O	ARG		68	−14.035	40.431	−34.454	1.00	41.37	O
ATOM	421	N	ARG		69	−12.350	39.572	−35.678	1.00	40.86	N
ATOM	422	CA	ARG		69	−13.217	38.955	−36.679	1.00	39.53	C
ATOM	423	CB	ARG		69	−13.147	39.729	−37.995	1.00	43.41	C
ATOM	424	CG	ARG		69	−14.046	40.953	−38.043	1.00	47.58	C
ATOM	425	CD	ARG		69	−13.773	41.777	−39.287	1.00	52.27	C
ATOM	426	NE	ARG		69	−13.590	40.936	−40.466	1.00	56.08	N
ATOM	427	CZ	ARG		69	−13.277	41.396	−41.673	1.00	58.81	C
ATOM	428	NH1	ARG		69	−13.114	42.698	−41.865	1.00	60.54	N
ATOM	429	NH2	ARG		69	−13.119	40.556	−42.688	1.00	59.95	N
ATOM	430	C	ARG		69	−12.772	37.508	−36.893	1.00	37.96	C
ATOM	431	O	ARG		69	−11.934	37.227	−37.751	1.00	36.44	O
ATOM	432	N	PRO		70	−13.330	36.570	−36.106	1.00	36.89	N
ATOM	433	CD	PRO		70	−14.289	36.845	−35.021	1.00	38.20	C
ATOM	434	CA	PRO		70	−13.019	35.137	−36.166	1.00	35.97	C
ATOM	435	CB	PRO		70	−13.655	34.598	−34.887	1.00	37.31	C
ATOM	436	CG	PRO		70	−14.851	35.471	−34.729	1.00	37.53	C
ATOM	437	C	PRO		70	−13.515	34.415	−37.414	1.00	34.97	C
ATOM	438	O	PRO		70	−14.282	33.447	−37.332	1.00	34.38	O
ATOM	439	N	SER		71	−13.047	34.874	−38.570	1.00	32.94	N
ATOM	440	CA	SER		71	−13.435	34.287	−39.848	1.00	30.60	C
ATOM	441	CB	SER		71	−14.826	34.797	−40.245	1.00	32.20	C
ATOM	442	OG	SER		71	−15.220	34.309	−41.516	1.00	37.57	O
ATOM	443	C	SER		71	−12.411	34.703	−40.898	1.00	28.59	C
ATOM	444	O	SER		71	−11.703	35.691	−40.710	1.00	27.43	O
ATOM	445	N	SER		72	−12.328	33.941	−41.985	1.00	27.81	N
ATOM	446	CA	SER		72	−11.406	34.240	−43.086	1.00	28.26	C
ATOM	447	CB	SER		72	−9.952	33.918	−42.703	1.00	25.68	C
ATOM	448	OG	SER		72	−9.714	32.518	−42.730	1.00	21.94	O
ATOM	449	C	SER		72	−11.797	33.400	−44.295	1.00	27.75	C
ATOM	450	O	SER		72	−12.712	32.586	−44.215	1.00	27.95	O
ATOM	451	N	TRP		73	−11.087	33.584	−45.405	1.00	28.49	N
ATOM	452	CA	TRP		73	−11.375	32.838	−46.621	1.00	27.17	C
ATOM	453	CB	TRP		73	−10.521	33.351	−47.792	1.00	27.62	C
ATOM	454	CG	TRP		73	−9.035	33.087	−47.648	1.00	28.44	C
ATOM	455	CD2	TRP		73	−8.326	31.921	−48.093	1.00	27.51	C
ATOM	456	CE2	TRP		73	−6.975	32.082	−47.714	1.00	26.68	C
ATOM	457	CE3	TRP		73	−8.703	30.755	−48.773	1.00	27.78	C
ATOM	458	CD1	TRP		73	−8.107	33.887	−47.035	1.00	27.25	C
ATOM	459	NE1	TRP		73	−6.868	33.288	−47.071	1.00	26.15	N
ATOM	460	CZ2	TRP		73	−5.997	31.118	−47.994	1.00	26.40	C
ATOM	461	CZ3	TRP		73	−7.726	29.794	−49.050	1.00	27.70	C
ATOM	462	CH2	TRP		73	−6.392	29.986	−48.658	1.00	26.52	C
ATOM	463	C	TRP		73	−11.121	31.352	−46.419	1.00	26.91	C
ATOM	464	O	TRP		73	−11.669	30.523	−47.139	1.00	27.03	O
ATOM	465	N	ARG		74	−10.298	31.017	−45.429	1.00	26.23	N
ATOM	466	CA	ARG		74	−9.968	29.624	−45.146	1.00	25.74	C
ATOM	467	CB	ARG		74	−8.696	29.536	−44.300	1.00	23.12	C
ATOM	468	CG	ARG		74	−7.503	30.297	−44.871	1.00	22.48	C
ATOM	469	CD	ARG		74	−6.217	29.755	−44.266	1.00	22.09	C
ATOM	470	NE	ARG		74	−6.071	28.352	−44.633	1.00	22.25	N
ATOM	471	CZ	ARG		74	−5.729	27.386	−43.792	1.00	23.61	C
ATOM	472	NH1	ARG		74	−5.489	27.663	−42.517	1.00	27.30	N
ATOM	473	NH2	ARG		74	−5.641	26.138	−44.230	1.00	25.35	N
ATOM	474	C	ARG		74	−11.094	28.882	−44.434	1.00	26.69	C
ATOM	475	O	ARG		74	−11.276	27.685	−44.640	1.00	25.48	O
ATOM	476	N	GLN		75	−11.825	29.583	−43.573	1.00	28.87	N
ATOM	477	CA	GLN		75	−12.942	28.970	−42.861	1.00	31.31	C
ATOM	478	CB	GLN		75	−12.450	28.048	−41.740	1.00	33.76	C
ATOM	479	CG	GLN		75	−11.543	28.688	−40.727	1.00	37.08	C
ATOM	480	CD	GLN		75	−11.212	27.745	−39.581	1.00	39.40	C
ATOM	481	OE1	GLN		75	−10.375	28.053	−38.731	1.00	39.41	O
ATOM	482	NE2	GLN		75	−11.875	26.593	−39.549	1.00	38.99	N
ATOM	483	C	GLN		75	−13.885	30.030	−42.307	1.00	29.89	C
ATOM	484	O	GLN		75	−13.457	31.011	−41.703	1.00	28.98	O
ATOM	485	N	GLU		76	−15.180	29.815	−42.524	1.00	30.41	N
ATOM	486	CA	GLU		76	−16.207	30.758	−42.102	1.00	28.77	C
ATOM	487	CB	GLU		76	−17.589	30.246	−42.537	1.00	28.89	C
ATOM	488	CG	GLU		76	−18.658	31.332	−42.562	1.00	28.30	C
ATOM	489	CD	GLU		76	−19.925	30.905	−43.299	1.00	28.54	C
ATOM	490	OE1	GLU		76	−20.809	31.764	−43.496	1.00	28.39	O
ATOM	491	OE2	GLU		76	−20.034	29.718	−43.681	1.00	25.51	O
ATOM	492	C	GLU		76	−16.211	31.078	−40.610	1.00	29.59	C
ATOM	493	O	GLU		76	−16.461	32.215	−40.215	1.00	28.90	O
ATOM	494	N	LYS		77	−15.932	30.082	−39.783	1.00	31.59	N
ATOM	495	CA	LYS		77	−15.918	30.285	−38.341	1.00	34.34	C
ATOM	496	CB	LYS		77	−17.096	29.536	−37.706	1.00	35.97	C
ATOM	497	CG	LYS		77	−17.260	29.743	−36.208	1.00	40.71	C
ATOM	498	CD	LYS		77	−17.760	31.143	−35.876	1.00	43.03	C
ATOM	499	CE	LYS		77	−17.985	31.305	−34.376	1.00	43.51	C
ATOM	500	NZ	LYS		77	−18.931	30.284	−33.837	1.00	44.93	N
ATOM	501	C	LYS		77	−14.602	29.784	−37.745	1.00	33.93	C
ATOM	502	O	LYS		77	−14.388	28.577	−37.638	1.00	33.50	O
ATOM	503	N	ILE		78	−13.728	30.715	−37.368	1.00	34.25	N
ATOM	504	CA	ILE		78	−12.437	30.373	−36.764	1.00	34.01	C
ATOM	505	CB	ILE		78	−11.446	31.564	−36.821	1.00	34.63	C
ATOM	506	CG2	ILE		78	−10.088	31.135	−36.269	1.00	33.43	C
ATOM	507	CG1	ILE		78	−11.298	32.074	−38.260	1.00	35.90	C
ATOM	508	CD1	ILE		78	−10.411	31.231	−39.142	1.00	35.86	C
ATOM	509	C	ILE		78	−12.688	30.046	−35.289	1.00	33.77	C
ATOM	510	O	ILE		78	−13.233	30.869	−34.559	1.00	33.99	O
ATOM	511	N	THR		79	−12.280	28.862	−34.846	1.00	33.32	N
ATOM	512	CA	THR		79	−12.501	28.478	−33.455	1.00	33.42	C
ATOM	513	CB	THR		79	−13.548	27.360	−33.370	1.00	34.16	C
ATOM	514	OG1	THR		79	−13.108	26.233	−34.138	1.00	35.23	O
ATOM	515	CG2	THR		79	−14.874	27.844	−33.915	1.00	35.13	C
ATOM	516	C	THR		79	−11.257	28.029	−32.685	1.00	32.98	C
ATOM	517	O	THR		79	−11.339	27.717	−31.496	1.00	31.73	O
ATOM	518	N	ARG		80	−10.107	27.986	−33.351	1.00	32.06	N
ATOM	519	CA	ARG		80	−8.883	27.570	−32.671	1.00	29.59	C
ATOM	520	CB	ARG		80	−7.710	27.534	−33.657	1.00	31.75	C
ATOM	521	CG	ARG		80	−7.267	28.907	−34.132	1.00	32.62	C
ATOM	522	CD	ARG		80	−5.975	28.855	−34.938	1.00	33.04	C
ATOM	523	NE	ARG		80	−6.207	28.717	−36.372	1.00	37.11	N
ATOM	524	CZ	ARG		80	−6.361	27.562	−37.005	1.00	37.45	C
ATOM	525	NH1	ARG		80	−6.304	26.421	−36.328	1.00	39.19	N
ATOM	526	NH2	ARG		80	−6.580	27.552	−38.317	1.00	35.65	N
ATOM	527	C	ARG		80	−8.584	28.555	−31.546	1.00	27.69	C
ATOM	528	O	ARG		80	−8.962	29.722	−31.620	1.00	27.39	O
ATOM	529	N	THR		81	−7.908	28.091	−30.502	1.00	26.96	N
ATOM	530	CA	THR		81	−7.569	28.965	−29.387	1.00	28.78	C
ATOM	531	CB	THR		81	−7.250	28.160	−28.123	1.00	29.00	C
ATOM	532	OG1	THR		81	−6.108	27.327	−28.363	1.00	29.98	O
ATOM	533	CG2	THR		81	−8.441	27.288	−27.736	1.00	29.94	C
ATOM	534	C	THR		81	−6.338	29.782	−29.749	1.00	29.24	C
ATOM	535	O	THR		81	−5.668	29.487	−30.737	1.00	28.92	O
ATOM	536	N	LYS		82	−6.044	30.808	−28.958	1.00	30.24	N
ATOM	537	CA	LYS		82	−4.864	31.635	−29.200	1.00	30.05	C
ATOM	538	CB	LYS		82	−4.756	32.750	−28.161	1.00	33.96	C
ATOM	539	CG	LYS		82	−5.863	33.780	−28.210	1.00	39.25	C
ATOM	540	CD	LYS		82	−5.616	34.887	−27.193	1.00	41.47	C
ATOM	541	CE	LYS		82	−5.531	34.333	−25.778	1.00	44.01	C
ATOM	542	NZ	LYS		82	−5.354	35.413	−24.770	1.00	44.71	N
ATOM	543	C	LYS		82	−3.621	30.751	−29.096	1.00	29.66	C
ATOM	544	O	LYS		82	−2.681	30.877	−29.884	1.00	25.85	O
ATOM	545	N	GLU		83	−3.628	29.861	−28.108	1.00	28.55	N
ATOM	546	CA	GLU		83	−2.505	28.953	−27.892	1.00	29.02	C
ATOM	547	CB	GLU		83	−2.760	28.075	−26.665	1.00	31.20	C
ATOM	548	CG	GLU		83	−2.852	28.854	−25.364	1.00	35.97	C
ATOM	549	CD	GLU		83	−4.156	29.626	−25.218	1.00	37.98	C
ATOM	550	OE1	GLU		83	−4.225	30.506	−24.335	1.00	41.29	O
ATOM	551	OE2	GLU		83	−5.111	29.350	−25.971	1.00	37.74	O
ATOM	552	C	GLU		83	−2.252	28.070	−29.108	1.00	26.59	C
ATOM	553	O	GLU		83	−1.104	27.875	−29.511	1.00	24.73	O
ATOM	554	N	GLU		84	−3.321	27.531	−29.685	1.00	25.40	N
ATOM	555	CA	GLU		84	−3.198	26.677	−30.866	1.00	25.25	C
ATOM	556	CB	GLU		84	−4.553	26.049	−31.223	1.00	26.42	C
ATOM	557	CG	GLU		84	−5.124	25.124	−30.153	1.00	29.77	C
ATOM	558	CD	GLU		84	−6.481	24.547	−30.539	1.00	31.27	C
ATOM	559	OE1	GLU		84	−7.409	25.336	−30.816	1.00	29.51	O
ATOM	560	OE2	GLU		84	−6.618	23.306	−30.564	1.00	33.67	O
ATOM	561	C	GLU		84	−2.686	27.500	−32.052	1.00	25.07	C
ATOM	562	O	GLU		84	−1.875	27.024	−32.849	1.00	24.45	O
ATOM	563	N	ALA		85	−3.163	28.735	−32.160	1.00	23.80	N
ATOM	564	CA	ALA		85	−2.743	29.625	−33.244	1.00	23.52	C
ATOM	565	CB	ALA		85	−3.535	30.926	−33.188	1.00	23.72	C
ATOM	566	C	ALA		85	−1.244	29.920	−33.146	1.00	23.46	C
ATOM	567	O	ALA		85	−0.544	29.994	−34.161	1.00	21.39	O
ATOM	568	N	LEU		86	−0.755	30.097	−31.922	1.00	22.67	N
ATOM	569	CA	LEU		86	0.662	30.370	−31.715	1.00	22.05	C
ATOM	570	CB	LEU		86	0.919	30.763	−30.258	1.00	22.26	C
ATOM	571	CG	LEU		86	2.363	31.118	−29.870	1.00	23.67	C
ATOM	572	CD1	LEU		86	2.868	32.269	−30.740	1.00	22.88	C
ATOM	573	CD2	LEU		86	2.419	31.515	−28.397	1.00	22.97	C
ATOM	574	C	LEU		86	1.503	29.149	−32.091	1.00	22.81	C
ATOM	575	O	LEU		86	2.604	29.286	−32.629	1.00	20.32	O
ATOM	576	N	GLU		87	0.997	27.953	−31.803	1.00	23.15	N
ATOM	577	CA	GLU		87	1.741	26.747	−32.144	1.00	25.76	C
ATOM	578	CB	GLU		87	1.070	25.503	−31.559	1.00	29.79	C
ATOM	579	CG	GLU		87	1.276	25.379	−30.062	1.00	35.40	C
ATOM	580	CD	GLU		87	2.739	25.533	−29.679	1.00	41.20	C
ATOM	581	OE1	GLU		87	3.564	24.709	−30.131	1.00	41.60	O
ATOM	582	OE2	GLU		87	3.066	26.485	−28.935	1.00	44.59	O
ATOM	583	C	GLU		87	1.869	26.617	−33.653	1.00	24.62	C
ATOM	584	O	GLU		87	2.903	26.169	−34.161	1.00	22.44	O
ATOM	585	N	LEU		88	0.816	27.007	−34.369	1.00	22.75	N
ATOM	586	CA	LEU		88	0.826	26.955	−35.829	1.00	21.50	C
ATOM	587	CB	LEU		88	−0.568	27.284	−36.382	1.00	20.56	C
ATOM	588	CG	LEU		88	−1.572	26.129	−36.310	1.00	23.77	C
ATOM	589	CD1	LEU		88	−3.008	26.642	−36.453	1.00	22.19	C
ATOM	590	CD2	LEU		88	−1.232	25.118	−37.401	1.00	22.20	C
ATOM	591	C	LEU		88	1.858	27.949	−36.363	1.00	19.42	C
ATOM	592	O	LEU		88	2.651	27.617	−37.252	1.00	19.73	O
ATOM	593	N	ILE		89	1.838	29.159	−35.809	1.00	18.57	N
ATOM	594	CA	ILE		89	2.763	30.227	−36.180	1.00	18.37	C
ATOM	595	CB	ILE		89	2.475	31.508	−35.349	1.00	18.61	C
ATOM	596	CG2	ILE		89	3.644	32.470	−35.435	1.00	18.86	C
ATOM	597	CG1	ILE		89	1.188	32.189	−35.842	1.00	17.15	C
ATOM	598	CD1	ILE		89	1.342	32.943	−37.163	1.00	16.22	C
ATOM	599	C	ILE		89	4.211	29.779	−35.932	1.00	20.19	C
ATOM	600	O	ILE		89	5.076	29.920	−36.804	1.00	18.74	O
ATOM	601	N	ASN		90	4.469	29.238	−34.743	1.00	18.44	N
ATOM	602	CA	ASN		90	5.813	28.785	−34.409	1.00	19.72	C
ATOM	603	CB	ASN		90	5.868	28.276	−32.964	1.00	21.36	C
ATOM	604	CG	ASN		90	5.759	29.396	−31.947	1.00	22.39	C
ATOM	605	OD1	ASN		90	6.183	30.523	−32.199	1.00	26.11	O
ATOM	606	ND2	ASN		90	5.209	29.083	−30.781	1.00	26.54	N
ATOM	607	C	ASN		90	6.300	27.691	−35.356	1.00	19.73	C
ATOM	608	O	ASN		90	7.490	27.608	−35.644	1.00	19.99	O
ATOM	609	N	GLY		91	5.381	26.857	−35.835	1.00	19.30	N
ATOM	610	CA	GLY		91	5.747	25.791	−36.749	1.00	19.27	C
ATOM	611	C	GLY		91	6.068	26.341	−38.126	1.00	20.36	C
ATOM	612	O	GLY		91	6.965	25.848	−38.818	1.00	19.68	O
ATOM	613	N	TYR		92	5.330	27.370	−38.534	1.00	18.26	N
ATOM	614	CA	TYR		92	5.569	27.991	−39.830	1.00	17.78	C
ATOM	615	CB	TYR		92	4.483	29.037	−40.136	1.00	18.19	C
ATOM	616	CG	TYR		92	3.107	28.437	−40.361	1.00	19.32	C
ATOM	617	CD1	TYR		92	1.953	29.162	−40.062	1.00	19.52	C
ATOM	618	CE1	TYR		92	0.684	28.618	−40.266	1.00	20.24	C
ATOM	619	CD2	TYR		92	2.960	27.146	−40.878	1.00	18.84	C
ATOM	620	CE2	TYR		92	1.695	26.592	−41.087	1.00	21.13	C
ATOM	621	CZ	TYR		92	0.559	27.338	−40.776	1.00	20.32	C
ATOM	622	OH	TYR		92	−0.697	26.797	−40.961	1.00	20.00	O
ATOM	623	C	TYR		92	6.936	28.659	−39.787	1.00	14.87	C
ATOM	624	O	TYR		92	7.679	28.597	−40.752	1.00	16.54	O
ATOM	625	N	ILE		93	7.257	29.293	−38.663	1.00	14.90	N
ATOM	626	CA	ILE		93	8.545	29.967	−38.500	1.00	17.95	C
ATOM	627	CB	ILE		93	8.623	30.724	−37.142	1.00	15.92	C
ATOM	628	CG2	ILE		93	10.071	31.164	−36.852	1.00	16.05	C
ATOM	629	CG1	ILE		93	7.742	31.979	−37.197	1.00	16.47	C
ATOM	630	CD1	ILE		93	7.580	32.684	−35.839	1.00	16.42	C
ATOM	631	C	ILE		93	9.697	28.966	−38.602	1.00	17.73	C
ATOM	632	O	ILE		93	10.721	29.249	−39.234	1.00	16.34	O
ATOM	633	N	GLN		94	9.531	27.797	−37.993	1.00	18.12	N
ATOM	634	CA	GLN		94	10.574	26.782	−38.054	1.00	21.32	C
ATOM	635	CB	GLN		94	10.217	25.579	−37.173	1.00	23.22	C
ATOM	636	CG	GLN		94	10.242	25.887	−35.691	1.00	25.92	C
ATOM	637	CD	GLN		94	10.036	24.654	−34.836	1.00	31.08	C
ATOM	638	OE1	GLN		94	9.063	23.913	−35.011	1.00	32.11	O
ATOM	639	NE2	GLN		94	10.949	24.428	−33.899	1.00	31.37	N
ATOM	640	C	GLN		94	10.813	26.317	−39.487	1.00	21.15	C
ATOM	641	O	GLN		94	11.959	26.177	−39.911	1.00	22.23	O
ATOM	642	N	LYS		95	9.739	26.086	−40.236	1.00	20.91	N
ATOM	643	CA	LYS		95	9.870	25.634	−41.617	1.00	20.41	C
ATOM	644	CB	LYS		95	8.511	25.205	−42.173	1.00	24.55	C
ATOM	645	CG	LYS		95	7.968	23.914	−41.577	1.00	29.78	C
ATOM	646	CD	LYS		95	6.720	23.454	−42.324	1.00	33.95	C
ATOM	647	CE	LYS		95	6.211	22.119	−41.793	1.00	36.40	C
ATOM	648	NZ	LYS		95	5.821	22.203	−40.352	1.00	40.21	N
ATOM	649	C	LYS		95	10.467	26.716	−42.508	1.00	19.44	C
ATOM	650	O	LYS		95	11.218	26.425	−43.439	1.00	19.34	O
ATOM	651	N	ILE		96	10.125	27.971	−42.234	1.00	18.25	N
ATOM	652	CA	ILE		96	10.659	29.070	−43.020	1.00	17.52	C
ATOM	653	CB	ILE		96	9.915	30.400	−42.704	1.00	17.35	C
ATOM	654	CG2	ILE		96	10.606	31.580	−43.412	1.00	15.30	C
ATOM	655	CG1	ILE		96	8.446	30.276	−43.144	1.00	17.27	C
ATOM	656	CD1	ILE		96	7.558	31.470	−42.767	1.00	18.12	C
ATOM	657	C	ILE		96	12.153	29.228	−42.734	1.00	16.25	C
ATOM	658	O	ILE		96	12.956	29.408	−43.654	1.00	17.72	O
ATOM	659	N	LYS		97	12.529	29.135	−41.462	1.00	15.88	N
ATOM	660	CA	LYS		97	13.928	29.290	−41.087	1.00	16.26	C
ATOM	661	CB	LYS		97	14.066	29.463	−39.570	1.00	15.39	C
ATOM	662	CG	LYS		97	13.806	30.889	−39.102	1.00	17.10	C
ATOM	663	CD	LYS		97	14.218	31.066	−37.662	1.00	15.69	C
ATOM	664	CE	LYS		97	14.103	32.515	−37.247	1.00	17.30	C
ATOM	665	NZ	LYS		97	14.552	32.706	−35.842	1.00	17.34	N
ATOM	666	C	LYS		97	14.807	28.142	−41.559	1.00	16.82	C
ATOM	667	O	LYS		97	15.978	28.352	−41.857	1.00	16.45	O
ATOM	668	N	SER		98	14.249	26.937	−41.620	1.00	17.13	N
ATOM	669	CA	SER		98	15.005	25.770	−42.086	1.00	19.37	C
ATOM	670	CB	SER		98	14.311	24.485	−41.647	1.00	18.74	C
ATOM	671	OG	SER		98	13.081	24.351	−42.335	1.00	18.36	O
ATOM	672	C	SER		98	15.121	25.770	−43.611	1.00	20.55	C
ATOM	673	O	SER		98	16.011	25.127	−44.185	1.00	19.81	O
ATOM	674	N	GLY		99	14.222	26.496	−44.272	1.00	19.70	N
ATOM	675	CA	GLY		99	14.248	26.537	−45.721	1.00	21.29	C
ATOM	676	C	GLY		99	13.406	25.422	−46.311	1.00	22.31	C
ATOM	677	O	GLY		99	13.325	25.270	−47.529	1.00	22.96	O
ATOM	678	N	GLU		100	12.776	24.637	−45.444	1.00	23.26	N
ATOM	679	CA	GLU		100	11.920	23.542	−45.888	1.00	26.21	C
ATOM	680	CB	GLU		100	11.427	22.738	−44.687	1.00	29.05	C
ATOM	681	CG	GLU		100	12.530	21.992	−43.959	1.00	37.13	C
ATOM	682	CD	GLU		100	12.045	21.325	−42.690	1.00	39.23	C
ATOM	683	OE1	GLU		100	11.630	22.046	−41.759	1.00	41.16	O
ATOM	684	OE2	GLU		100	12.075	20.080	−42.627	1.00	43.56	O
ATOM	685	C	GLU		100	10.728	24.116	−46.647	1.00	27.02	C
ATOM	686	O	GLU		100	10.204	23.488	−47.561	1.00	28.15	O
ATOM	687	N	GLU		101	10.308	25.316	−46.261	1.00	26.21	N
ATOM	688	CA	GLU		101	9.188	25.998	−46.907	1.00	28.61	C
ATOM	689	CB	GLU		101	7.894	25.785	−46.110	1.00	31.42	C
ATOM	690	CG	GLU		101	7.207	24.457	−46.362	1.00	34.52	C
ATOM	691	CD	GLU		101	6.440	24.445	−47.669	1.00	36.26	C
ATOM	692	OE1	GLU		101	7.039	24.748	−48.723	1.00	39.55	O
ATOM	693	OE2	GLU		101	5.234	24.130	−47.643	1.00	39.14	O
ATOM	694	C	GLU		101	9.511	27.478	−46.930	1.00	28.01	C
ATOM	695	O	GLU		101	10.175	27.974	−46.027	1.00	30.29	O
ATOM	696	N	ASP		102	9.068	28.197	−47.951	1.00	26.68	N
ATOM	697	CA	ASP		102	9.355	29.618	−47.949	1.00	27.54	C
ATOM	698	CB	ASP		102	9.834	30.103	−49.329	1.00	34.37	C
ATOM	699	CG	ASP		102	8.865	29.786	−50.441	1.00	37.59	C
ATOM	700	OD1	ASP		102	9.310	29.741	−51.609	1.00	43.05	O
ATOM	701	OD2	ASP		102	7.668	29.594	−50.157	1.00	41.47	O
ATOM	702	C	ASP		102	8.138	30.387	−47.462	1.00	25.40	C
ATOM	703	O	ASP		102	7.011	29.890	−47.487	1.00	23.71	O
ATOM	704	N	PHE		103	8.391	31.588	−46.974	1.00	23.34	N
ATOM	705	CA	PHE		103	7.353	32.450	−46.446	1.00	22.31	C
ATOM	706	CB	PHE		103	7.955	33.825	−46.158	1.00	22.80	C
ATOM	707	CG	PHE		103	6.962	34.816	−45.672	1.00	23.87	C
ATOM	708	CD1	PHE		103	6.597	34.850	−44.335	1.00	24.41	C
ATOM	709	CD2	PHE		103	6.317	35.659	−46.570	1.00	25.76	C
ATOM	710	CE1	PHE		103	5.595	35.702	−43.897	1.00	24.83	C
ATOM	711	CE2	PHE		103	5.313	36.516	−46.140	1.00	25.51	C
ATOM	712	CZ	PHE		103	4.951	36.534	−44.803	1.00	24.29	C
ATOM	713	C	PHE		103	6.151	32.597	−47.379	1.00	20.99	C
ATOM	714	O	PHE		103	5.005	32.426	−46.962	1.00	19.12	O
ATOM	715	N	GLU		104	6.426	32.915	−48.639	1.00	19.24	N
ATOM	716	CA	GLU		104	5.388	33.123	−49.645	1.00	21.00	C
ATOM	717	CB	GLU		104	6.030	33.509	−50.987	1.00	21.52	C
ATOM	718	CG	GLU		104	6.796	34.828	−50.940	1.00	22.25	C
ATOM	719	CD	GLU		104	8.230	34.677	−50.470	1.00	23.23	C
ATOM	720	OE1	GLU		104	8.557	33.677	−49.789	1.00	23.13	O
ATOM	721	OE2	GLU		104	9.036	35.575	−50.777	1.00	26.74	O
ATOM	722	C	GLU		104	4.459	31.940	−49.854	1.00	20.60	C
ATOM	723	O	GLU		104	3.247	32.111	−50.029	1.00	21.04	O
ATOM	724	N	SER		105	5.023	30.742	−49.851	1.00	20.47	N
ATOM	725	CA	SER		105	4.226	29.542	−50.049	1.00	22.89	C
ATOM	726	CB	SER		105	5.133	28.328	−50.232	1.00	23.63	C
ATOM	727	OG	SER		105	4.368	27.149	−50.326	1.00	25.68	O
ATOM	728	C	SER		105	3.280	29.304	−48.878	1.00	21.76	C
ATOM	729	O	SER		105	2.095	29.027	−49.078	1.00	22.05	O
ATOM	730	N	LEU		106	3.801	29.406	−47.660	1.00	20.34	N
ATOM	731	CA	LEU		106	2.982	29.198	−46.465	1.00	18.95	C
ATOM	732	CB	LEU		106	3.861	29.178	−45.208	1.00	16.50	C
ATOM	733	CG	LEU		106	4.929	28.075	−45.157	1.00	17.18	C
ATOM	734	CD1	LEU		106	5.640	28.119	−43.799	1.00	15.09	C
ATOM	735	CD2	LEU		106	4.284	26.711	−45.373	1.00	16.73	C
ATOM	736	C	LEU		106	1.924	30.287	−46.331	1.00	19.01	C
ATOM	737	O	LEU		106	0.802	30.021	−45.882	1.00	19.62	O
ATOM	738	N	ALA		107	2.280	31.513	−46.700	1.00	19.32	N
ATOM	739	CA	ALA		107	1.330	32.618	−46.629	1.00	20.46	C
ATOM	740	CB	ALA		107	2.019	33.932	−46.973	1.00	20.80	C
ATOM	741	C	ALA		107	0.154	32.378	−47.581	1.00	21.20	C
ATOM	742	O	ALA		107	−1.013	32.494	−47.184	1.00	20.09	O
ATOM	743	N	SER		108	0.458	32.042	−48.834	1.00	19.42	N
ATOM	744	CA	SER		108	−0.586	31.798	−49.827	1.00	20.67	C
ATOM	745	CB	SER		108	0.038	31.430	−51.179	1.00	21.16	C
ATOM	746	OG	SER		108	0.864	32.479	−51.658	1.00	26.10	O
ATOM	747	C	SER		108	−1.505	30.667	−49.380	1.00	21.18	C
ATOM	748	O	SER		108	−2.707	30.671	−49.654	1.00	21.09	O
ATOM	749	N	GLN		109	−0.931	29.705	−48.671	1.00	20.49	N
ATOM	750	CA	GLN		109	−1.681	28.551	−48.214	1.00	22.48	C
ATOM	751	CB	GLN		109	−0.750	27.351	−48.088	1.00	22.52	C
ATOM	752	CG	GLN		109	−0.254	26.790	−49.392	1.00	23.08	C
ATOM	753	CD	GLN		109	0.724	25.666	−49.166	1.00	25.92	C
ATOM	754	OE1	GLN		109	1.930	25.888	−49.042	1.00	26.77	O
ATOM	755	NE2	GLN		109	0.209	24.450	−49.090	1.00	24.41	N
ATOM	756	C	GLN		109	−2.427	28.683	−46.900	1.00	21.83	C
ATOM	757	O	GLN		109	−3.587	28.311	−46.801	1.00	20.58	O
ATOM	758	N	PHE		110	−1.757	29.221	−45.892	1.00	21.69	N
ATOM	759	CA	PHE		110	−2.353	29.274	−44.574	1.00	22.41	C
ATOM	760	CB	PHE		110	−1.471	28.442	−43.645	1.00	21.55	C
ATOM	761	CG	PHE		110	−1.139	27.080	−44.201	1.00	21.62	C
ATOM	762	CD1	PHE		110	0.174	26.732	−44.499	1.00	21.24	C
ATOM	763	CD2	PHE		110	−2.149	26.157	−44.455	1.00	21.95	C
ATOM	764	CE1	PHE		110	0.474	25.485	−45.044	1.00	24.45	C
ATOM	765	CE2	PHE		110	−1.864	24.912	−44.996	1.00	22.45	C
ATOM	766	CZ	PHE		110	−0.551	24.571	−45.294	1.00	24.44	C
ATOM	767	C	PHE		110	−2.687	30.606	−43.928	1.00	22.56	C
ATOM	768	O	PHE		110	−3.248	30.628	−42.839	1.00	23.57	O
ATOM	769	N	SER		111	−2.367	31.719	−44.571	1.00	21.02	N
ATOM	770	CA	SER		111	−2.697	32.997	−43.961	1.00	21.58	C
ATOM	771	CB	SER		111	−2.030	34.146	−44.691	1.00	18.53	C
ATOM	772	OG	SER		111	−2.347	35.369	−44.036	1.00	20.21	O
ATOM	773	C	SER		111	−4.206	33.242	−43.951	1.00	22.85	C
ATOM	774	O	SER		111	−4.876	33.071	−44.975	1.00	22.36	O
ATOM	775	N	ASP		112	−4.722	33.648	−42.793	1.00	23.38	N
ATOM	776	CA	ASP		112	−6.145	33.937	−42.619	1.00	25.80	C
ATOM	777	CB	ASP		112	−6.578	33.724	−41.159	1.00	24.20	C
ATOM	778	CG	ASP		112	−6.822	32.261	−40.820	1.00	26.33	C
ATOM	779	OD1	ASP		112	−7.520	31.578	−41.599	1.00	26.12	O
ATOM	780	OD2	ASP		112	−6.333	31.789	−39.767	1.00	23.37	O
ATOM	781	C	ASP		112	−6.436	35.379	−43.008	1.00	25.72	C
ATOM	782	O	ASP		112	−7.283	36.030	−42.406	1.00	28.16	O
ATOM	783	N	CYS		113	−5.723	35.884	−44.004	1.00	26.38	N
ATOM	784	CA	CYS		113	−5.914	37.252	−44.458	1.00	25.54	C
ATOM	785	CB	CYS		113	−4.672	38.090	−44.141	1.00	24.34	C
ATOM	786	SG	CYS		113	−4.765	39.850	−44.586	1.00	26.84	S
ATOM	787	C	CYS		113	−6.154	37.234	−45.954	1.00	25.63	C
ATOM	788	O	CYS		113	−5.685	36.337	−46.651	1.00	25.42	O
ATOM	789	N	SER		114	−6.891	38.224	−46.444	1.00	24.84	N
ATOM	790	CA	SER		114	−7.181	38.321	−47.870	1.00	25.86	C
ATOM	791	CB	SER		114	−8.167	39.469	−48.132	1.00	26.75	C
ATOM	792	OG	SER		114	−7.695	40.692	−47.593	1.00	29.35	O
ATOM	793	C	SER		114	−5.893	38.542	−48.667	1.00	25.32	C
ATOM	794	O	SER		114	−5.840	38.261	−49.872	1.00	24.77	O
ATOM	795	N	SER		115	−4.854	39.033	−47.995	1.00	23.19	N
ATOM	796	CA	SER		115	−3.572	39.278	−48.664	1.00	22.81	C
ATOM	797	CB	SER		115	−2.665	40.159	−47.798	1.00	20.33	C
ATOM	798	OG	SER		115	−2.422	39.568	−46.531	1.00	20.91	O
ATOM	799	C	SER		115	−2.849	37.975	−49.001	1.00	21.09	C
ATOM	800	O	SER		115	−1.799	37.989	−49.640	1.00	20.29	O
ATOM	801	N	ALA		116	−3.412	36.849	−48.574	1.00	20.25	N
ATOM	802	CA	ALA		116	−2.824	35.546	−48.855	1.00	19.33	C
ATOM	803	CB	ALA		116	−3.664	34.441	−48.217	1.00	22.64	C
ATOM	804	C	ALA		116	−2.750	35.329	−50.368	1.00	21.09	C
ATOM	805	O	ALA		116	−1.811	34.707	−50.870	1.00	17.16	O
ATOM	806	N	LYS		117	−3.747	35.845	−51.088	1.00	18.87	N
ATOM	807	CA	LYS		117	−3.806	35.699	−52.542	1.00	20.20	C
ATOM	808	CB	LYS		117	−5.134	36.257	−53.068	1.00	23.03	C
ATOM	809	CG	LYS		117	−6.366	35.604	−52.451	1.00	29.17	C
ATOM	810	CD	LYS		117	−6.627	34.220	−53.029	1.00	31.39	C
ATOM	811	CE	LYS		117	−7.717	33.479	−52.245	1.00	34.23	C
ATOM	812	NZ	LYS		117	−7.223	33.034	−50.901	1.00	32.34	N
ATOM	813	C	LYS		117	−2.640	36.404	−53.228	1.00	19.22	C
ATOM	814	O	LYS		117	−2.336	36.131	−54.392	1.00	17.70	O
ATOM	815	N	ALA		118	−1.999	37.319	−52.508	1.00	17.95	N
ATOM	816	CA	ALA		118	−0.854	38.045	−53.038	1.00	19.01	C
ATOM	817	CB	ALA		118	−1.085	39.551	−52.930	1.00	17.73	C
ATOM	818	C	ALA		118	0.411	37.643	−52.272	1.00	19.64	C
ATOM	819	O	ALA		118	1.288	38.470	−52.015	1.00	19.72	O
ATOM	820	N	ARG		119	0.489	36.366	−51.915	1.00	18.61	N
ATOM	821	CA	ARG		119	1.634	35.825	−51.189	1.00	21.48	C
ATOM	822	CB	ARG		119	2.889	35.863	−52.079	1.00	24.72	C
ATOM	823	CG	ARG		119	2.947	34.743	−53.119	1.00	27.85	C
ATOM	824	CD	ARG		119	3.738	35.130	−54.367	1.00	31.89	C
ATOM	825	NE	ARG		119	2.901	35.895	−55.290	1.00	38.23	N
ATOM	826	CZ	ARG		119	2.579	37.180	−55.144	1.00	38.28	C
ATOM	827	NH1	ARG		119	3.033	37.886	−54.112	1.00	39.89	N
ATOM	828	NH2	ARG		119	1.763	37.753	−56.016	1.00	33.97	N
ATOM	829	C	ARG		119	1.881	36.589	−49.893	1.00	20.62	C
ATOM	830	O	ARG		119	3.008	36.656	−49.407	1.00	18.56	O
ATOM	831	N	GLY		120	0.817	37.171	−49.343	1.00	20.89	N
ATOM	832	CA	GLY		120	0.934	37.908	−48.094	1.00	21.30	C
ATOM	833	C	GLY		120	1.363	39.359	−48.201	1.00	22.05	C
ATOM	834	O	GLY		120	1.426	40.053	−47.191	1.00	21.34	O
ATOM	835	N	ASP		121	1.640	39.832	−49.414	1.00	22.44	N
ATOM	836	CA	ASP		121	2.073	41.214	−49.608	1.00	22.42	C
ATOM	837	CB	ASP		121	2.534	41.429	−51.053	1.00	22.20	C
ATOM	838	CG	ASP		121	2.921	42.870	−51.334	1.00	23.17	C
ATOM	839	OD1	ASP		121	3.600	43.489	−50.487	1.00	21.32	O
ATOM	840	OD2	ASP		121	2.553	43.381	−52.410	1.00	22.33	O
ATOM	841	C	ASP		121	0.990	42.232	−49.262	1.00	24.01	C
ATOM	842	O	ASP		121	−0.141	42.132	−49.728	1.00	22.67	O
ATOM	843	N	LEU		122	1.363	43.219	−48.450	1.00	24.20	N
ATOM	844	CA	LEU		122	0.449	44.263	−48.017	1.00	25.71	C
ATOM	845	CB	LEU		122	0.580	44.482	−46.510	1.00	24.03	C
ATOM	846	CG	LEU		122	0.179	43.321	−45.610	1.00	24.14	C
ATOM	847	CD1	LEU		122	0.457	43.698	−44.155	1.00	22.74	C
ATOM	848	CD2	LEU		122	−1.294	43.007	−45.818	1.00	23.98	C
ATOM	849	C	LEU		122	0.701	45.589	−48.710	1.00	26.77	C
ATOM	850	O	LEU		122	−0.069	46.530	−48.541	1.00	27.12	O
ATOM	851	N	GLY		123	1.777	45.666	−49.481	1.00	28.17	N
ATOM	852	CA	GLY		123	2.101	46.913	−50.144	1.00	28.92	C
ATOM	853	C	GLY		123	2.829	47.781	−49.138	1.00	30.04	C
ATOM	854	O	GLY		123	3.054	47.356	−48.003	1.00	30.87	O
ATOM	855	N	ALA		124	3.198	48.992	−49.537	1.00	28.94	N
ATOM	856	CA	ALA		124	3.910	49.892	−48.641	1.00	30.19	C
ATOM	857	CB	ALA		124	4.740	50.886	−49.451	1.00	30.74	C
ATOM	858	C	ALA		124	2.928	50.635	−47.746	1.00	31.41	C
ATOM	859	O	ALA		124	1.744	50.747	−48.064	1.00	31.90	O
ATOM	860	N	PHE		125	3.419	51.128	−46.615	1.00	31.96	N
ATOM	861	CA	PHE		125	2.576	51.868	−45.683	1.00	32.00	C
ATOM	862	CB	PHE		125	1.660	50.907	−44.905	1.00	32.14	C
ATOM	863	CG	PHE		125	2.394	49.832	−44.132	1.00	32.47	C
ATOM	864	CD1	PHE		125	3.038	50.126	−42.932	1.00	32.28	C
ATOM	865	CD2	PHE		125	2.421	48.519	−44.601	1.00	32.76	C
ATOM	866	CE1	PHE		125	3.697	49.131	−42.206	1.00	31.38	C
ATOM	867	CE2	PHE		125	3.077	47.514	−43.885	1.00	32.65	C
ATOM	868	CZ	PHE		125	3.717	47.822	−42.681	1.00	30.91	C
ATOM	869	C	PHE		125	3.406	52.709	−44.726	1.00	31.21	C
ATOM	870	O	PHE		125	4.608	52.498	−44.578	1.00	32.99	O
ATOM	871	N	SER		126	2.765	53.677	−44.087	1.00	32.12	N
ATOM	872	CA	SER		126	3.460	54.540	−43.145	1.00	33.01	C
ATOM	873	CB	SER		126	3.303	56.008	−43.551	1.00	34.29	C
ATOM	874	OG	SER		126	1.941	56.376	−43.561	1.00	35.69	O
ATOM	875	C	SER		126	2.885	54.315	−41.755	1.00	31.94	C
ATOM	876	O	SER		126	1.956	53.524	−41.579	1.00	31.18	O
ATOM	877	N	ARG		127	3.439	55.003	−40.766	1.00	33.72	N
ATOM	878	CA	ARG		127	2.957	54.855	−39.404	1.00	34.85	C
ATOM	879	CB	ARG		127	3.920	55.528	−38.424	1.00	34.40	C
ATOM	880	CG	ARG		127	5.199	54.736	−38.160	1.00	33.60	C
ATOM	881	CD	ARG		127	5.993	55.353	−37.018	1.00	32.21	C
ATOM	882	NE	ARG		127	7.195	54.598	−36.658	1.00	31.62	N
ATOM	883	CZ	ARG		127	7.211	53.507	−35.893	1.00	30.76	C
ATOM	884	NH1	ARG		127	6.085	53.018	−35.396	1.00	27.78	N
ATOM	885	NH2	ARG		127	8.364	52.916	−35.604	1.00	30.85	N
ATOM	886	C	ARG		127	1.553	55.428	−39.238	1.00	37.37	C
ATOM	887	O	ARG		127	1.233	56.485	−39.787	1.00	37.57	O
ATOM	888	N	GLY		128	0.716	54.713	−38.494	1.00	38.78	N
ATOM	889	CA	GLY		128	−0.641	55.166	−38.253	1.00	40.45	C
ATOM	890	C	GLY		128	−1.716	54.449	−39.047	1.00	40.51	C
ATOM	891	O	GLY		128	−2.903	54.663	−38.811	1.00	42.58	O
ATOM	892	N	GLN		129	−1.313	53.592	−39.979	1.00	38.75	N
ATOM	893	CA	GLN		129	−2.272	52.871	−40.807	1.00	37.32	C
ATOM	894	CB	GLN		129	−1.742	52.754	−42.238	1.00	39.24	C
ATOM	895	CG	GLN		129	−1.226	54.057	−42.833	1.00	41.99	C
ATOM	896	CD	GLN		129	−0.708	53.885	−44.256	1.00	43.29	C
ATOM	897	OE1	GLN		129	−0.117	54.799	−44.826	1.00	44.89	O
ATOM	898	NE2	GLN		129	−0.934	52.711	−44.832	1.00	45.91	N
ATOM	899	C	GLN		129	−2.583	51.474	−40.278	1.00	36.07	C
ATOM	900	O	GLN		129	−3.736	51.044	−40.269	1.00	36.17	O
ATOM	901	N	MET		130	−1.552	50.761	−39.839	1.00	33.33	N
ATOM	902	CA	MET		130	−1.741	49.407	−39.340	1.00	32.52	C
ATOM	903	CB	MET		130	−0.554	48.532	−39.760	1.00	31.71	C
ATOM	904	CG	MET		130	−0.244	48.572	−41.249	1.00	33.63	C
ATOM	905	SD	MET		130	−1.533	47.832	−42.264	1.00	36.73	S
ATOM	906	CE	MET		130	−0.783	47.898	−43.882	1.00	36.14	C
ATOM	907	C	MET		130	−1.871	49.390	−37.823	1.00	31.76	C
ATOM	908	O	MET		130	−1.551	50.373	−37.157	1.00	31.56	O
ATOM	909	N	GLN		131	−2.348	48.274	−37.279	1.00	31.61	N
ATOM	910	CA	GLN		131	−2.474	48.154	−35.834	1.00	32.12	C
ATOM	911	CB	GLN		131	−3.005	46.777	−35.471	1.00	34.43	C
ATOM	912	CG	GLN		131	−4.400	46.572	−36.018	1.00	37.18	C
ATOM	913	CD	GLN		131	−4.967	45.226	−35.680	1.00	38.83	C
ATOM	914	OE1	GLN		131	−5.108	44.877	−34.510	1.00	43.14	O
ATOM	915	NE2	GLN		131	−5.298	44.455	−36.703	1.00	39.26	N
ATOM	916	C	GLN		131	−1.093	48.402	−35.249	1.00	31.69	C
ATOM	917	O	GLN		131	−0.080	47.971	−35.807	1.00	31.12	O
ATOM	918	N	LYS		132	−1.061	49.113	−34.130	1.00	28.74	N
ATOM	919	CA	LYS		132	0.183	49.499	−33.492	1.00	26.91	C
ATOM	920	CB	LYS		132	−0.123	50.136	−32.133	1.00	27.76	C
ATOM	921	CG	LYS		132	1.037	50.907	−31.535	1.00	27.78	C
ATOM	922	CD	LYS		132	1.653	51.862	−32.532	1.00	26.57	C
ATOM	923	CE	LYS		132	2.829	52.600	−31.910	1.00	27.44	C
ATOM	924	NZ	LYS		132	3.657	53.293	−32.928	1.00	28.79	N
ATOM	925	C	LYS		132	1.273	48.434	−33.342	1.00	26.22	C
ATOM	926	O	LYS		132	2.423	48.679	−33.707	1.00	25.72	O
ATOM	927	N	PRO		133	0.936	47.254	−32.797	1.00	24.78	N
ATOM	928	CD	PRO		133	−0.361	46.831	−32.242	1.00	26.39	C
ATOM	929	CA	PRO		133	1.944	46.198	−32.628	1.00	26.25	C
ATOM	930	CB	PRO		133	1.148	45.060	−31.990	1.00	27.61	C
ATOM	931	CG	PRO		133	0.055	45.778	−31.247	1.00	27.91	C
ATOM	932	C	PRO		133	2.573	45.782	−33.959	1.00	25.91	C
ATOM	933	O	PRO		133	3.787	45.566	−34.048	1.00	25.34	O
ATOM	934	N	PHE		134	1.733	45.676	−34.984	1.00	25.36	N
ATOM	935	CA	PHE		134	2.172	45.288	−36.326	1.00	23.87	C
ATOM	936	CB	PHE		134	0.950	45.094	−37.225	1.00	22.16	C
ATOM	937	CG	PHE		134	1.269	44.499	−38.570	1.00	20.35	C
ATOM	938	CD1	PHE		134	1.143	43.131	−38.783	1.00	18.13	C
ATOM	939	CD2	PHE		134	1.691	45.307	−39.618	1.00	19.91	C
ATOM	940	CE1	PHE		134	1.433	42.567	−40.030	1.00	19.24	C
ATOM	941	CE2	PHE		134	1.985	44.758	−40.870	1.00	18.90	C
ATOM	942	CZ	PHE		134	1.855	43.383	−41.075	1.00	19.12	C
ATOM	943	C	PHE		134	3.058	46.389	−36.898	1.00	23.25	C
ATOM	944	O	PHE		134	4.102	46.128	−37.502	1.00	22.16	O
ATOM	945	N	GLU		135	2.636	47.634	−36.698	1.00	23.54	N
ATOM	946	CA	GLU		135	3.391	48.778	−37.188	1.00	22.32	C
ATOM	947	CB	GLU		135	2.626	50.067	−36.890	1.00	23.65	C
ATOM	948	CG	GLU		135	3.431	51.324	−37.128	1.00	25.84	C
ATOM	949	CD	GLU		135	2.699	52.563	−36.657	1.00	28.66	C
ATOM	950	OE1	GLU		135	1.533	52.743	−37.064	1.00	28.63	O
ATOM	951	OE2	GLU		135	3.290	53.346	−35.883	1.00	30.94	O
ATOM	952	C	GLU		135	4.794	48.859	−36.585	1.00	22.06	C
ATOM	953	O	GLU		135	5.792	48.958	−37.313	1.00	19.26	O
ATOM	954	N	ASP		136	4.877	48.829	−35.257	1.00	21.97	N
ATOM	955	CA	ASP		136	6.176	48.913	−34.590	1.00	21.65	C
ATOM	956	CB	ASP		136	6.016	48.909	−33.064	1.00	24.59	C
ATOM	957	CG	ASP		136	5.397	50.196	−32.538	1.00	24.60	C
ATOM	958	OD1	ASP		136	5.452	51.217	−33.251	1.00	24.55	O
ATOM	959	OD2	ASP		136	4.866	50.188	−31.411	1.00	25.54	O
ATOM	960	C	ASP		136	7.094	47.781	−35.010	1.00	20.28	C
ATOM	961	O	ASP		136	8.282	47.997	−35.243	1.00	20.40	O
ATOM	962	N	ALA		137	6.547	46.576	−35.114	1.00	20.56	N
ATOM	963	CA	ALA		137	7.347	45.430	−35.534	1.00	20.52	C
ATOM	964	CB	ALA		137	6.503	44.150	−35.480	1.00	20.41	C
ATOM	965	C	ALA		137	7.855	45.675	−36.961	1.00	20.52	C
ATOM	966	O	ALA		137	9.034	45.483	−37.254	1.00	19.91	O
ATOM	967	N	SER		138	6.966	46.132	−37.838	1.00	20.50	N
ATOM	968	CA	SER		138	7.332	46.392	−39.229	1.00	21.18	C
ATOM	969	CB	SER		138	6.121	46.885	−40.028	1.00	20.16	C
ATOM	970	OG	SER		138	5.124	45.886	−40.118	1.00	18.18	O
ATOM	971	C	SER		138	8.459	47.396	−39.381	1.00	22.52	C
ATOM	972	O	SER		138	9.391	47.164	−40.152	1.00	21.15	O
ATOM	973	N	PHE		139	8.371	48.511	−38.654	1.00	22.86	N
ATOM	974	CA	PHE		139	9.386	49.559	−38.726	1.00	24.53	C
ATOM	975	CB	PHE		139	8.806	50.906	−38.272	1.00	24.41	C
ATOM	976	CG	PHE		139	7.967	51.582	−39.320	1.00	24.60	C
ATOM	977	CD1	PHE		139	6.624	51.264	−39.471	1.00	24.06	C
ATOM	978	CD2	PHE		139	8.541	52.503	−40.195	1.00	26.09	C
ATOM	979	CE1	PHE		139	5.861	51.852	−40.483	1.00	25.14	C
ATOM	980	CE2	PHE		139	7.786	53.096	−41.211	1.00	25.07	C
ATOM	981	CZ	PHE		139	6.446	52.768	−41.353	1.00	24.16	C
ATOM	982	C	PHE		139	10.661	49.279	−37.942	1.00	25.70	C
ATOM	983	O	PHE		139	11.638	50.027	−38.052	1.00	26.40	O
ATOM	984	N	ALA		140	10.653	48.209	−37.155	1.00	24.62	N
ATOM	985	CA	ALA		140	11.820	47.841	−36.363	1.00	24.11	C
ATOM	986	CB	ALA		140	11.377	47.346	−34.993	1.00	22.14	C
ATOM	987	C	ALA		140	12.617	46.758	−37.096	1.00	24.35	C
ATOM	988	O	ALA		140	13.802	46.543	−36.824	1.00	23.36	O
ATOM	989	N	LEU		141	11.958	46.077	−38.028	1.00	25.20	N
ATOM	990	CA	LEU		141	12.615	45.040	−38.815	1.00	25.89	C
ATOM	991	CB	LEU		141	11.590	44.234	−39.625	1.00	25.61	C
ATOM	992	CG	LEU		141	10.696	43.197	−38.942	1.00	25.20	C
ATOM	993	CD1	LEU		141	9.626	42.727	−39.923	1.00	22.19	C
ATOM	994	CD2	LEU		141	11.536	42.015	−38.466	1.00	24.10	C
ATOM	995	C	LEU		141	13.579	45.695	−39.790	1.00	27.21	C
ATOM	996	O	LEU		141	13.336	46.811	−40.254	1.00	27.62	O
ATOM	997	N	ARG		142	14.681	45.013	−40.084	1.00	26.14	N
ATOM	998	CA	ARG		142	15.638	45.516	−41.054	1.00	26.46	C
ATOM	999	CB	ARG		142	17.029	44.932	−40.789	1.00	27.29	C
ATOM	1000	CG	ARG		142	17.614	45.279	−39.416	1.00	27.36	C
ATOM	1001	CD	ARG		142	18.966	44.615	−39.227	1.00	30.93	C
ATOM	1002	NE	ARG		142	18.847	43.157	−39.178	1.00	33.42	N
ATOM	1003	CZ	ARG		142	18.768	42.448	−38.057	1.00	32.99	C
ATOM	1004	NH1	ARG		142	18.805	43.062	−36.882	1.00	32.06	C
ATOM	1005	NH2	ARG		142	18.638	41.127	−38.111	1.00	31.91	N
ATOM	1006	C	ARG		142	15.096	45.009	−42.388	1.00	27.13	C
ATOM	1007	O	ARG		142	14.310	44.062	−42.414	1.00	25.87	O
ATOM	1008	N	THR		143	15.496	45.626	−43.493	1.00	27.88	N
ATOM	1009	CA	THR		143	15.017	45.190	−44.800	1.00	27.91	C
ATOM	1010	CB	THR		143	15.606	46.054	−45.926	1.00	30.84	C
ATOM	1011	OG1	THR		143	15.344	47.432	−45.647	1.00	34.68	O
ATOM	1012	CG2	THR		143	14.976	45.691	−47.266	1.00	30.42	C
ATOM	1013	C	THR		143	15.413	43.737	−45.039	1.00	27.33	C
ATOM	1014	O	THR		143	16.585	43.370	−44.895	1.00	24.82	O
ATOM	1015	N	GLY		144	14.428	42.916	−45.394	1.00	24.57	N
ATOM	1016	CA	GLY		144	14.681	41.505	−45.636	1.00	25.36	C
ATOM	1017	C	GLY		144	14.530	40.618	−44.406	1.00	24.34	C
ATOM	1018	O	GLY		144	14.527	39.386	−44.518	1.00	24.89	O
ATOM	1019	N	GLU		145	14.399	41.235	−43.234	1.00	22.32	N
ATOM	1020	CA	GLU		145	14.257	40.498	−41.976	1.00	21.64	C
ATOM	1021	CB	GLU		145	14.792	41.341	−40.810	1.00	20.75	C
ATOM	1022	CG	GLU		145	14.707	40.651	−39.452	1.00	24.18	C
ATOM	1023	CD	GLU		145	15.227	41.512	−38.314	1.00	26.80	C
ATOM	1024	OE1	GLU		145	15.339	42.746	−38.498	1.00	26.95	O
ATOM	1025	OE2	GLU		145	15.509	40.958	−37.229	1.00	25.61	O
ATOM	1026	C	GLU		145	12.820	40.056	−41.678	1.00	20.47	C
ATOM	1027	O	GLU		145	11.848	40.691	−42.098	1.00	20.76	O
ATOM	1028	N	MET		146	12.699	38.957	−40.943	1.00	19.00	N
ATOM	1029	CA	MET		146	11.397	38.407	−40.580	1.00	19.12	C
ATOM	1030	CB	MET		146	11.311	36.940	−41.020	1.00	20.03	C
ATOM	1031	CG	MET		146	9.944	36.296	−40.835	1.00	18.34	C
ATOM	1032	SD	MET		146	9.907	34.578	−41.401	1.00	18.12	S
ATOM	1033	CE	MET		146	10.702	33.776	−40.020	1.00	17.76	C
ATOM	1034	C	MET		146	11.196	38.520	−39.072	1.00	18.91	C
ATOM	1035	O	MET		146	12.146	38.407	−38.289	1.00	15.75	O
ATOM	1036	N	SER		147	9.955	38.738	−38.661	1.00	17.79	N
ATOM	1037	CA	SER		147	9.651	38.873	−37.247	1.00	17.17	C
ATOM	1038	CB	SER		147	8.412	39.752	−37.060	1.00	16.31	C
ATOM	1039	OG	SER		147	7.258	39.013	−37.452	1.00	16.54	O
ATOM	1040	C	SER		147	9.351	37.524	−36.617	1.00	16.94	C
ATOM	1041	O	SER		147	9.291	36.498	−37.296	1.00	15.50	O
ATOM	1042	N	GLY		148	9.184	37.552	−35.299	1.00	18.15	N
ATOM	1043	CA	GLY		148	8.802	36.365	−34.566	1.00	20.27	C
ATOM	1044	C	GLY		148	7.299	36.540	−34.455	1.00	20.89	C
ATOM	1045	O	GLY		148	6.734	37.338	−35.202	1.00	20.31	O
ATOM	1046	N	PRO		149	6.616	35.830	−33.552	1.00	22.08	N
ATOM	1047	CD	PRO		149	7.077	34.695	−32.736	1.00	21.15	C
ATOM	1048	CA	PRO		149	5.163	36.003	−33.446	1.00	21.27	C
ATOM	1049	CB	PRO		149	4.760	34.946	−32.416	1.00	22.62	C
ATOM	1050	CG	PRO		149	5.807	33.894	−32.568	1.00	23.25	C
ATOM	1051	C	PRO		149	4.794	37.413	−32.979	1.00	21.78	C
ATOM	1052	O	PRO		149	5.242	37.852	−31.920	1.00	19.81	O
ATOM	1053	N	VAL		150	3.984	38.116	−33.771	1.00	19.75	N
ATOM	1054	CA	VAL		150	3.545	39.467	−33.410	1.00	19.92	C
ATOM	1055	CB	VAL		150	3.870	40.485	−34.515	1.00	19.06	C
ATOM	1056	CG1	VAL		150	3.323	41.859	−34.137	1.00	17.37	C
ATOM	1057	CG2	VAL		150	5.389	40.563	−34.725	1.00	20.06	C
ATOM	1058	C	VAL		150	2.033	39.439	−33.170	1.00	20.76	C
ATOM	1059	O	VAL		150	1.268	39.011	−34.037	1.00	20.27	O
ATOM	1060	N	PHE		151	1.605	39.900	−31.996	1.00	20.33	N
ATOM	1061	CA	PHE		151	0.185	39.880	−31.651	1.00	22.41	C
ATOM	1062	CB	PHE		151	0.009	39.471	−30.176	1.00	22.53	C
ATOM	1063	CG	PHE		151	0.625	38.140	−29.831	1.00	23.14	C
ATOM	1064	CD1	PHE		151	2.000	38.012	−29.678	1.00	21.63	C
ATOM	1065	CD2	PHE		151	−0.172	37.012	−29.668	1.00	22.87	C
ATOM	1066	CE1	PHE		151	2.575	36.776	−29.365	1.00	23.30	C
ATOM	1067	CE2	PHE		151	0.393	35.771	−29.354	1.00	22.95	C
ATOM	1068	CZ	PHE		151	1.769	35.655	−29.203	1.00	21.34	C
ATOM	1069	C	PHE		151	−0.555	41.202	−31.893	1.00	23.09	C
ATOM	1070	O	PHE		151	−0.017	42.285	−31.652	1.00	24.09	O
ATOM	1071	N	THR		152	−1.786	41.097	−32.390	1.00	23.44	N
ATOM	1072	CA	THR		152	−2.648	42.259	−32.634	1.00	24.04	C
ATOM	1073	CB	THR		152	−2.596	42.755	−34.091	1.00	23.18	C
ATOM	1074	OG1	THR		152	−3.228	41.781	−34.935	1.00	23.10	O
ATOM	1075	CG2	THR		152	−1.159	42.995	−34.537	1.00	23.92	C
ATOM	1076	C	THR		152	−4.072	41.778	−32.398	1.00	23.73	C
ATOM	1077	O	THR		152	−4.289	40.611	−32.092	1.00	23.51	O
ATOM	1078	N	ASP		153	−5.048	42.665	−32.561	1.00	27.44	N
ATOM	1079	CA	ASP		153	−6.437	42.268	−32.370	1.00	29.62	C
ATOM	1080	CB	ASP		153	−7.341	43.503	−32.292	1.00	33.87	C
ATOM	1081	CG	ASP		153	−7.091	44.324	−31.045	1.00	37.22	C
ATOM	1082	OD1	ASP		153	−7.003	43.724	−29.956	1.00	38.69	O
ATOM	1083	OD2	ASP		153	−6.988	45.565	−31.147	1.00	40.78	O
ATOM	1084	C	ASP		153	−6.929	41.335	−33.473	1.00	29.34	C
ATOM	1085	O	ASP		153	−7.957	40.682	−33.316	1.00	30.86	O
ATOM	1086	N	SER		154	−6.200	41.276	−34.588	1.00	27.23	N
ATOM	1087	CA	SER		154	−6.575	40.406	−35.702	1.00	25.69	C
ATOM	1088	CB	SER		154	−5.897	40.854	−37.005	1.00	26.20	C
ATOM	1089	OG	SER		154	−6.144	42.210	−37.294	1.00	28.56	O
ATOM	1090	C	SER		154	−6.171	38.960	−35.437	1.00	24.84	C
ATOM	1091	O	SER		154	−6.858	38.028	−35.854	1.00	22.64	O
ATOM	1092	N	GLY		155	−5.043	38.784	−34.750	1.00	23.43	N
ATOM	1093	CA	GLY		155	−4.549	37.449	−34.462	1.00	22.29	C
ATOM	1094	C	GLY		155	−3.046	37.480	−34.240	1.00	21.28	C
ATOM	1095	O	GLY		155	−2.523	38.419	−33.639	1.00	22.08	O
ATOM	1096	N	ILE		156	−2.350	36.458	−34.728	1.00	20.17	N
ATOM	1097	CA	ILE		156	−0.902	36.373	−34.575	1.00	18.79	C
ATOM	1098	CB	ILE		156	−0.507	35.048	−33.896	1.00	19.07	C
ATOM	1099	CG2	ILE		156	1.001	35.030	−33.602	1.00	20.72	C
ATOM	1100	CG1	ILE		156	−1.304	34.881	−32.594	1.00	18.77	C
ATOM	1101	CD1	ILE		156	−1.065	33.557	−31.900	1.00	17.80	C
ATOM	1102	C	ILE		156	−0.289	36.438	−35.967	1.00	19.38	C
ATOM	1103	O	ILE		156	−0.727	35.722	−36.875	1.00	18.34	O
ATOM	1104	N	HIS		157	0.722	37.286	−36.135	1.00	18.01	N
ATOM	1105	CA	HIS		157	1.356	37.451	−37.438	1.00	19.24	C
ATOM	1106	CB	HIS		157	1.283	38.910	−37.916	1.00	19.95	C
ATOM	1107	CG	HIS		157	−0.031	39.587	−37.688	1.00	21.88	C
ATOM	1108	CD2	HIS		157	−0.720	39.848	−36.551	1.00	21.84	C
ATOM	1109	ND1	HIS		157	−0.733	40.190	−38.708	1.00	20.39	N
ATOM	1110	CE1	HIS		157	−1.795	40.799	−38.211	1.00	23.64	C
ATOM	1111	NE2	HIS		157	−1.811	40.607	−36.904	1.00	21.95	N
ATOM	1112	C	HIS		157	2.839	37.102	−37.484	1.00	19.21	C
ATOM	1113	O	HIS		157	3.541	37.156	−36.475	1.00	19.34	O
ATOM	1114	N	ILE		158	3.288	36.751	−38.686	1.00	18.54	N
ATOM	1115	CA	ILE		158	4.688	36.511	−38.975	1.00	17.73	C
ATOM	1116	CB	ILE		158	4.960	35.163	−39.644	1.00	19.32	C
ATOM	1117	CG2	ILE		158	6.413	35.120	−40.090	1.00	20.23	C
ATOM	1118	CG1	ILE		158	4.689	34.016	−38.668	1.00	19.48	C
ATOM	1119	CD1	ILE		158	4.783	32.633	−39.314	1.00	20.27	C
ATOM	1120	C	ILE		158	4.852	37.615	−40.016	1.00	18.12	C
ATOM	1121	O	ILE		158	4.118	37.649	−41.013	1.00	18.44	O
ATOM	1122	N	ILE		159	5.800	38.513	−39.784	1.00	17.05	N
ATOM	1123	CA	ILE		159	6.003	39.651	−40.670	1.00	18.79	C
ATOM	1124	CB	ILE		159	5.913	40.975	−39.870	1.00	18.39	C
ATOM	1125	CG2	ILE		159	6.015	42.170	−40.815	1.00	19.94	C
ATOM	1126	CG1	ILE		159	4.610	41.001	−39.062	1.00	20.68	C
ATOM	1127	CD1	ILE		159	4.461	42.216	−38.129	1.00	17.02	C
ATOM	1128	C	ILE		159	7.328	39.642	−41.417	1.00	18.45	C
ATOM	1129	O	ILE		159	8.383	39.418	−40.831	1.00	20.19	O
ATOM	1130	N	LEU		160	7.263	39.886	−42.720	1.00	18.39	N
ATOM	1131	CA	LEU		160	8.476	39.947	−43.528	1.00	18.91	C
ATOM	1132	CB	LEU		160	8.453	38.901	−44.650	1.00	16.90	C
ATOM	1133	CG	LEU		160	9.663	38.977	−45.592	1.00	18.75	C
ATOM	1134	CD1	LEU		160	10.915	38.508	−44.852	1.00	19.35	C
ATOM	1135	CD2	LEU		160	9.436	38.117	−46.829	1.00	17.69	C
ATOM	1136	C	LEU		160	8.566	41.333	−44.140	1.00	19.09	C
ATOM	1137	O	LEU		160	7.689	41.736	−44.901	1.00	20.34	O
ATOM	1138	N	ARG		161	9.616	42.068	−43.792	1.00	21.02	N
ATOM	1139	CA	ARG		161	9.808	43.397	−44.346	1.00	22.02	C
ATOM	1140	CB	ARG		161	10.633	44.282	−43.412	1.00	21.72	C
ATOM	1141	CG	ARG		161	10.864	45.646	−44.032	1.00	24.85	C
ATOM	1142	CD	ARG		161	11.712	46.578	−43.197	1.00	27.39	C
ATOM	1143	NE	ARG		161	12.036	47.761	−43.992	1.00	27.33	N
ATOM	1144	CZ	ARG		161	12.907	48.695	−43.634	1.00	29.68	C
ATOM	1145	NH1	ARG		161	13.551	48.596	−42.478	1.00	28.60	N
ATOM	1146	NH2	ARG		161	13.144	49.719	−44.443	1.00	27.90	N
ATOM	1147	C	ARG		161	10.538	43.236	−45.673	1.00	21.63	C
ATOM	1148	O	ARG		161	11.654	42.729	−45.714	1.00	21.71	O
ATOM	1149	N	THR		162	9.905	43.676	−46.751	1.00	20.78	N
ATOM	1150	CA	THR		162	10.487	43.541	−48.077	1.00	22.60	C
ATOM	1151	CB	THR		162	9.421	43.066	−49.085	1.00	22.27	C
ATOM	1152	OG1	THR		162	8.274	43.921	−49.013	1.00	22.96	O
ATOM	1153	CG2	THR		162	8.992	41.636	−48.764	1.00	22.61	C
ATOM	1154	C	THR		162	11.146	44.814	−48.591	1.00	23.00	C
ATOM	1155	O	THR		162	12.029	44.753	−49.441	1.00	22.65	O
ATOM	1156	N	GLU		163	10.718	45.961	−48.078	1.00	24.32	N
ATOM	1157	CA	GLU		163	11.284	47.242	−48.490	1.00	26.46	C
ATOM	1158	CB	GLU		163	10.445	47.850	−49.620	1.00	28.32	C
ATOM	1159	CG	GLU		163	10.507	47.101	−50.943	1.00	30.56	C
ATOM	1160	CD	GLU		163	9.525	47.652	−51.969	1.00	32.59	C
ATOM	1161	OE1	GLU		163	9.172	48.850	−51.881	1.00	33.11	O
ATOM	1162	OE2	GLU		163	9.115	46.891	−52.870	1.00	33.50	O
ATOM	1163	C	GLU		163	11.304	48.214	−47.311	1.00	27.33	C
ATOM	1164	O	GLU		163	10.445	48.066	−46.416	1.00	28.13	O
ATOM	1165	OXT	GLU		163	12.156	49.128	−47.312	1.00	27.53	O
ATOM	1166	OH2	WAT	S	1	7.893	41.331	−27.148	1.00	20.05	O
ATOM	1167	OH2	WAT	S	2	17.346	30.491	−41.153	1.00	19.42	O
ATOM	1168	OH2	WAT	S	3	−4.284	32.127	−51.291	1.00	20.44	O
ATOM	1169	OH2	WAT	S	4	−1.352	36.952	−45.720	1.00	20.58	O
ATOM	1170	OH2	WAT	S	5	2.568	25.068	−38.010	1.00	22.22	O
ATOM	1171	OH2	WAT	S	6	15.546	44.418	−36.331	1.00	22.22	O
ATOM	1172	OH2	WAT	S	7	6.032	42.545	−49.458	1.00	21.44	O
ATOM	1173	OH2	WAT	S	8	13.801	42.245	−35.291	1.00	26.16	O
ATOM	1174	OH2	WAT	S	9	−0.917	36.386	−56.614	1.00	22.75	O
ATOM	1175	OH2	WAT	S	10	9.461	29.022	−34.080	1.00	23.06	O
ATOM	1176	OH2	WAT	S	11	−0.374	33.895	−53.631	1.00	22.72	O
ATOM	1177	OH2	WAT	S	12	1.353	54.881	−34.353	1.00	29.58	O
ATOM	1178	OH2	WAT	S	13	−10.315	27.273	−36.239	1.00	27.61	O
ATOM	1179	OH2	WAT	S	14	−3.068	27.728	−39.878	1.00	22.17	O
ATOM	1180	OH2	WAT	S	15	20.327	33.128	−36.148	1.00	23.99	O
ATOM	1181	OH2	WAT	S	16	14.045	43.523	−21.728	1.00	29.71	O
ATOM	1182	OH2	WAT	S	17	−3.857	45.355	−32.255	1.00	29.16	O
ATOM	1183	OH2	WAT	S	18	1.002	51.896	−39.707	1.00	38.48	O
ATOM	1184	OH2	WAT	S	19	12.908	30.336	−46.148	1.00	22.55	O
ATOM	1185	OH2	WAT	S	20	16.527	38.495	−36.902	1.00	27.58	O
ATOM	1186	OH2	WAT	S	21	−2.331	24.038	−48.848	1.00	32.35	O
ATOM	1187	OH2	WAT	S	22	0.917	34.371	−56.164	1.00	27.90	O
ATOM	1188	OH2	WAT	S	23	4.931	38.281	−50.188	1.00	28.56	O
ATOM	1189	OH2	WAT	S	24	13.874	36.942	−43.530	1.00	26.39	O
ATOM	1190	OH2	WAT	S	25	17.618	32.933	−36.603	1.00	30.83	O
ATOM	1191	OH2	WAT	S	26	−8.129	29.096	−40.568	1.00	27.75	O
ATOM	1192	OH2	WAT	S	27	−3.679	37.727	−30.843	1.00	31.15	O
ATOM	1193	OH2	WAT	S	28	9.282	50.419	−34.337	1.00	30.75	O
ATOM	1194	OH2	WAT	S	29	27.012	23.613	−24.655	1.00	29.62	O
ATOM	1195	OH2	WAT	S	30	−4.557	29.710	−40.751	1.00	28.97	O
ATOM	1196	OH2	WAT	S	31	−0.997	24.226	−41.494	1.00	33.22	O
ATOM	1197	OH2	WAT	S	32	16.353	29.577	−24.662	1.00	31.58	O
ATOM	1198	OH2	WAT	S	33	25.743	33.873	−30.490	1.00	25.85	O
ATOM	1199	OH2	WAT	S	34	5.332	45.143	−31.658	1.00	30.16	O
ATOM	1200	OH2	WAT	S	35	14.920	35.643	−24.808	1.00	33.85	O
ATOM	1201	OH2	WAT	S	36	15.290	31.392	−31.500	1.00	27.63	O
ATOM	1202	OH2	WAT	S	37	−6.894	26.860	−47.045	1.00	33.52	O
ATOM	1203	OH2	WAT	S	38	−7.398	46.846	−28.941	1.00	51.90	O
ATOM	1204	OH2	WAT	S	39	10.653	22.662	−39.314	1.00	45.55	O
ATOM	1205	OH2	WAT	S	40	18.244	24.600	−19.261	1.00	38.82	O
ATOM	1206	OH2	WAT	S	41	−15.687	27.400	−43.454	1.00	34.30	O
ATOM	1207	OH2	WAT	S	42	−18.597	27.618	−44.427	1.00	32.89	O
ATOM	1208	OH2	WAT	S	43	6.049	37.358	−53.977	1.00	36.68	O
ATOM	1209	OH2	WAT	S	44	19.052	43.889	−43.831	1.00	34.72	O
ATOM	1210	OH2	WAT	S	45	15.461	47.913	−34.992	1.00	31.23	O
ATOM	1211	OH2	WAT	S	46	20.837	37.225	−38.207	1.00	28.28	O
ATOM	1212	OH2	WAT	S	47	19.507	45.526	−23.866	1.00	47.05	O
ATOM	1213	OH2	WAT	S	48	17.325	48.028	−43.296	1.00	48.61	O
ATOM	1214	OH2	WAT	S	49	17.907	34.411	−21.643	1.00	38.49	O
ATOM	1215	OH2	WAT	S	50	5.070	47.615	−29.795	1.00	38.43	O
ATOM	1216	OH2	WAT	S	51	−8.466	32.182	−28.123	1.00	37.74	O
ATOM	1217	OH2	WAT	S	52	11.537	34.750	−30.892	1.00	38.98	O
ATOM	1218	O1	PGA	B	180	16.565	30.648	−29.156	1.00	34.95	O
ATOM	1219	C2	PGA	B	180	17.916	30.499	−29.151	1.00	30.97	C
ATOM	1220	C3	PGA	B	180	18.549	31.257	−30.326	1.00	29.19	C
ATOM	1221	O4	PGA	B	180	18.179	30.717	−31.480	1.00	27.98	O
ATOM	1222	C5	PGA	B	180	18.543	31.454	−32.527	1.00	24.65	C
ATOM	1223	C6	PGA	B	180	18.061	30.765	−33.815	1.00	27.19	C
ATOM	1224	O7	PGA	B	180	16.757	30.428	−33.686	1.00	28.41	O
ATOM	1225	C8	PGA	B	180	16.320	29.679	−34.708	1.00	26.90	C
ATOM	1226	C9	PGA	B	180	14.835	29.337	−34.488	1.00	27.50	C
ATOM	1227	O10	PGA	B	180	14.108	30.481	−34.359	1.00	28.64	O
ATOM	1228	C11	PGA	B	180	12.816	30.227	−34.105	1.00	27.73	C
ATOM	1229	C12	PGA	B	180	12.129	31.509	−33.596	1.00	29.25	C
ATOM	1230	O13	PGA	B	180	12.280	32.504	−34.479	1.00	27.90	O
ATOM	1231	C14	PGA	B	180	11.635	33.590	−34.048	1.00	30.91	C
ATOM	1232	C15	PGA	B	180	11.739	34.725	−35.087	1.00	30.86	C
ATOM	1233	O16	PGA	B	180	13.005	35.098	−35.301	1.00	28.94	O
ATOM	1234	C17	PGA	B	180	13.004	35.725	−36.434	1.00	35.98	C
ATOM	1235	C18	PGA	B	180	14.387	36.187	−36.862	1.00	36.33	C
ATOM	1236	O19	PGA	B	180	14.291	36.621	−38.093	1.00	34.83	O
ATOM	1237	O1	PGB	C	181	−2.961	45.735	−38.887	1.00	35.85	O
ATOM	1238	C2	PGB	C	181	−2.391	44.535	−38.920	1.00	38.14	C
ATOM	1239	C3	PGB	C	181	−2.092	44.102	−40.376	1.00	37.17	C
ATOM	1240	O4	PGB	C	181	−3.218	43.989	−41.089	1.00	39.98	O
ATOM	1241	C5	PGB	C	181	−2.951	43.671	−42.381	1.00	41.36	C
ATOM	1242	C6	PGB	C	181	−4.245	43.666	−43.231	1.00	43.82	C
ATOM	1243	O7	PGB	C	181	−4.709	44.927	−43.388	1.00	45.09	O
ATOM	1244	S	SO4		190	−9.615	41.396	−38.442	1.00	58.70	S
ATOM	1245	O1	SO4		190	−9.696	40.211	−37.557	1.00	58.17	O
ATOM	1246	O2	SO4		190	−8.575	42.323	−37.939	1.00	57.55	O
ATOM	1247	O3	SO4		190	−10.923	42.101	−38.448	1.00	58.85	O
ATOM	1248	O4	SO4		190	−9.294	40.994	−39.836	1.00	57.04	O
END

Example 2

Activity-Based Assay for Inhibitor Evaluation

[0190] The proline isomerase activity assay is based on the method described by Fisher et al. (Biomed. Biochim. Acta, 1984, 43:1101-1111). Specifically, the enzyme (112 ng) was preincubated with 72 mM substrate at 4° C. for 30 minutes in an 80 μL reaction volume containing 0.02 mg/μL BSA, 0.8 mM DTT, and 35 mM HEPES (pH 7.8). Proteolysis of the substrate was initiated by the addition of 80 μL of trypsin at 0.4 mg/mL in 35 mM HEPES (pH 7.8) and the release of p-nitroaniline was monitored every 10 seconds at 390 nm using a microplate reader (MRD/8V/DIAS, Dynex Technologies). Inhibition studies were preformed by adding 5 μL of inhibitors added in the pre-incubation mix. Inhibitors were at 0.4 mg/mL in 10% DMSO.

Example 3

Structural Determination of Pin1 R14A/Inhibitor Complexes

[0191] Pin1 R14A/Inhibitor Complex

[0192] Crystals of Pin1 R14A were obtained as previously specified in Example 1. Crystals of Pin1 R14A were transferred to a solution of 50 mM HEPES (pH 7.5), 30% PEG containing the various inhibitors.

[0193] The Pin1 R14A crystal form yields stable crystals that diffract to high resolution. The proline isomerase (peptidyl-prolyl cis-trans isomerase) active site is exposed within the crystal lattice to the large solvent channels within the crystal. The immediate area around the center of this active site is not involved with any critical protein-protein crystal contacts. Thus, soluble compounds have access to the PPIase active site of already formed crystals. This then allows for the soaking of Pin1 R14A crystals in solutions containing any desired soluble ligand, giving the ligand the access needed to bind to the active site. Crystal soaking does not then require a reoptimization of the crystallization conditions, and any number of solutions can be screened, thus increasing the speed at which ligand-protein structures may be determined. Pin1 R14A/Pin-077 Interactions The crystal structure of the co-complex with PIN-077 (the coordinates set is set forth in Table 2), shows that the sulfate moiety of this molecule makes four hydrogen bond contacts in the basic pocket (with Ser154, Arg69, and Lys63) and that the hydroxyl groups on the proximal ring hydrogen bond to the nitrogen of the Arg69 sidechain and to Lys63. This interaction with sulfate moiety of PIN-077 is different than that observed for the sulfate ion in the Pin1 R14A crystal structure, in that PIN-077 binds deeper into the basic pocket and displaces a water molecule that was interacting with Arg69 peptide nitrogen. Investigation of the remainder of the structure demonstrated that the remaining two rings of PIN-077 do not bind in the active site cavity and protrude out of the active site. Interestingly, it was observed that a polyethylene glycol molecule was bound in the hydrophobic pocket showing the formation of a hydrogen bond between the hydroxyl group of the polyethylene glycol molecule and a backbone nitrogen atom (Gln131) of the Pin1 polypeptide.

TABLE 2
Set of atomic coordinates of Pin1 R14A with PIN-077 and PEG bound in the active site.
ATOM	1	CB	LYS		6	4.089	106.181	−14.909	1.00	62.82	C
ATOM	2	CG	LYS		6	4.748	105.929	−13.561	1.00	63.71	C
ATOM	3	CD	LYS		6	4.011	106.671	−12.454	1.00	64.79	C
ATOM	4	CE	LYS		6	4.710	106.508	−11.111	1.00	65.58	C
ATOM	5	NZ	LYS		6	4.028	107.272	−10.024	1.00	65.16	N
ATOM	6	C	LYS		6	4.690	104.085	−16.160	1.00	60.82	C
ATOM	7	O	LYS		6	4.132	103.469	−15.247	1.00	60.67	O
ATOM	8	N	LYS		6	4.340	106.209	−17.370	1.00	62.35	N
ATOM	9	CA	LYS		6	4.851	105.605	−16.107	1.00	61.77	C
ATOM	10	N	LEU		7	5.180	103.499	−17.250	1.00	58.91	N
ATOM	11	CA	LEU		7	5.132	102.056	−17.478	1.00	56.07	C
ATOM	12	CB	LEU		7	5.498	101.295	−16.197	1.00	56.64	C
ATOM	13	CG	LEU		7	6.919	101.478	−15.652	1.00	56.81	C
ATOM	14	CD1	LEU		7	7.099	100.654	−14.384	1.00	56.09	C
ATOM	15	CD2	LEU		7	7.926	101.057	−16.708	1.00	55.86	C
ATOM	16	C	LEU		7	3.792	101.547	−17.998	1.00	53.87	C
ATOM	17	O	LEU		7	2.774	101.634	−17.314	1.00	52.42	O
ATOM	18	N	PRO		8	3.783	101.009	−19.228	1.00	52.27	N
ATOM	19	CD	PRO		8	4.915	101.003	−20.172	1.00	52.41	C
ATOM	20	CA	PRO		8	2.578	100.468	−19.866	1.00	51.26	C
ATOM	21	CB	PRO		8	3.115	99.896	−21.176	1.00	51.93	C
ATOM	22	CG	PRO		8	4.222	100.840	−21.509	1.00	52.37	C
ATOM	23	C	PRO		8	1.915	99.400	−18.989	1.00	49.93	C
ATOM	24	O	PRO		8	2.487	98.963	−17.988	1.00	49.55	O
ATOM	25	N	PRO		9	0.703	98.957	−19.367	1.00	48.16	N
ATOM	26	CD	PRO		9	−0.041	99.406	−20.558	1.00	47.50	C
ATOM	27	CA	PRO		9	−0.066	97.944	−18.632	1.00	46.31	C
ATOM	28	CB	PRO		9	−1.220	97.636	−19.587	1.00	46.59	C
ATOM	29	CG	PRO		9	−1.452	98.954	−20.247	1.00	47.31	C
ATOM	30	C	PRO		9	0.671	96.673	−18.194	1.00	44.67	C
ATOM	31	O	PRO		9	1.154	95.898	−19.026	1.00	43.04	O
ATOM	32	N	GLY		10	0.744	96.473	−16.877	1.00	43.13	N
ATOM	33	CA	GLY		10	1.374	95.285	−16.327	1.00	40.91	C
ATOM	34	C	GLY		10	2.867	95.289	−16.042	1.00	38.94	C
ATOM	35	O	GLY		10	3.392	94.294	−15.543	1.00	36.23	O
ATOM	36	N	TRP		11	3.553	96.388	−16.344	1.00	38.92	N
ATOM	37	CA	TRP		11	4.995	96.468	−16.113	1.00	38.40	C
ATOM	38	CB	TRP		11	5.649	97.420	−17.119	1.00	35.93	C
ATOM	39	CG	TRP		11	5.669	96.894	−18.512	1.00	32.90	C
ATOM	40	CD2	TRP		11	6.601	95.951	−19.058	1.00	33.87	C
ATOM	41	CE2	TRP		11	6.221	95.715	−20.399	1.00	32.37	C
ATOM	42	CE3	TRP		11	7.722	95.281	−18.543	1.00	31.97	C
ATOM	43	CD1	TRP		11	4.788	97.183	−19.512	1.00	32.74	C
ATOM	44	NE1	TRP		11	5.112	96.479	−20.650	1.00	32.67	N
ATOM	45	CZ2	TRP		11	6.920	94.839	−21.232	1.00	31.65	C
ATOM	46	CZ3	TRP		11	8.416	94.410	−19.371	1.00	31.60	C
ATOM	47	CH2	TRP		11	8.013	94.197	−20.704	1.00	32.70	C
ATOM	48	C	TRP		11	5.381	96.897	−14.703	1.00	39.33	C
ATOM	49	O	TRP		11	4.680	97.684	−14.065	1.00	39.85	O
ATOM	50	N	GLU		12	6.508	96.365	−14.229	1.00	39.72	N
ATOM	51	CA	GLU		12	7.034	96.681	−12.903	1.00	40.19	C
ATOM	52	CB	GLU		12	6.582	95.640	−11.876	1.00	42.16	C
ATOM	53	CG	GLU		12	7.169	94.253	−12.104	1.00	46.75	C
ATOM	54	CD	GLU		12	6.944	93.312	−10.934	1.00	48.75	C
ATOM	55	OE1	GLU		12	5.776	93.129	−10.525	1.00	50.08	O
ATOM	56	OE2	GLU		12	7.938	92.750	−10.428	1.00	50.44	O
ATOM	57	C	GLU		12	8.564	96.717	−12.930	1.00	40.03	C
ATOM	58	O	GLU		12	9.202	96.046	−13.744	1.00	37.52	O
ATOM	59	N	LYS		13	9.145	97.502	−12.029	1.00	39.79	N
ATOM	60	CA	LYS		13	10.594	97.628	−11.937	1.00	39.84	C
ATOM	61	CB	LYS		13	10.964	98.930	−11.221	1.00	42.55	C
ATOM	62	CG	LYS		13	12.458	99.209	−11.144	1.00	45.64	C
ATOM	63	CD	LYS		13	12.765	100.361	−10.189	1.00	47.35	C
ATOM	64	CE	LYS		13	12.123	101.670	−10.646	1.00	49.42	C
ATOM	65	NZ	LYS		13	12.373	102.793	−9.687	1.00	49.08	N
ATOM	66	C	LYS		13	11.132	96.443	−11.153	1.00	39.36	C
ATOM	67	O	LYS		13	10.535	96.022	−10.160	1.00	39.91	O
ATOM	68	N	ALA		14	12.255	95.895	−11.600	1.00	37.26	N
ATOM	69	CA	ALA		14	12.850	94.761	−10.912	1.00	36.51	C
ATOM	70	CB	ALA		14	12.538	93.468	−11.657	1.00	36.81	C
ATOM	71	C	ALA		14	14.354	94.941	−10.773	1.00	35.92	C
ATOM	72	O	ALA		14	14.941	95.866	−11.341	1.00	33.23	O
ATOM	73	N	MET		15	14.969	94.039	−10.018	1.00	36.46	N
ATOM	74	CA	MET		15	16.401	94.079	−9.770	1.00	36.73	C
ATOM	75	CB	MET		15	16.643	94.355	−8.285	1.00	40.40	C
ATOM	76	CG	MET		15	18.099	94.471	−7.906	1.00	43.53	C
ATOM	77	SD	MET		15	18.814	95.858	−8.764	1.00	48.38	S
ATOM	78	CE	MET		15	18.202	97.216	−7.757	1.00	45.86	C
ATOM	79	C	MET		15	17.049	92.754	−10.155	1.00	35.73	C
ATOM	80	O	MET		15	16.668	91.704	−9.638	1.00	34.75	O
ATOM	81	N	SER		16	18.026	92.794	−11.055	1.00	34.08	N
ATOM	82	CA	SER		16	18.700	91.565	−11.462	1.00	34.19	C
ATOM	83	CB	SER		16	19.674	91.829	−12.608	1.00	34.05	C
ATOM	84	OG	SER		16	20.389	90.645	−12.924	1.00	33.48	O
ATOM	85	C	SER		16	19.467	90.969	−10.288	1.00	34.88	C
ATOM	86	O	SER		16	20.165	91.681	−9.568	1.00	34.56	O
ATOM	87	N	ARG		17	19.335	89.660	−10.106	1.00	36.97	N
ATOM	88	CA	ARG		17	20.008	88.950	−9.022	1.00	39.64	C
ATOM	89	CB	ARG		17	19.350	87.587	−8.795	1.00	40.65	C
ATOM	90	CG	ARG		17	17.993	87.651	−8.135	1.00	41.99	C
ATOM	91	CD	ARG		17	18.109	88.207	−6.732	1.00	42.76	C
ATOM	92	NE	ARG		17	16.799	88.434	−6.135	1.00	44.85	N
ATOM	93	CZ	ARG		17	15.966	87.471	−5.753	1.00	44.86	C
ATOM	94	NH1	ARG		17	16.299	86.193	−5.897	1.00	43.83	N
ATOM	95	NH2	ARG		17	14.793	87.793	−5.232	1.00	45.08	N
ATOM	96	C	ARG		17	21.486	88.732	−9.301	1.00	40.72	C
ATOM	97	O	ARG		17	22.297	88.653	−8.378	1.00	40.92	O
ATOM	98	N	SER		18	21.828	88.626	−10.579	1.00	41.09	N
ATOM	99	CA	SER		18	23.205	88.387	−10.988	1.00	41.84	C
ATOM	100	CB	SER		18	23.220	87.624	−12.317	1.00	42.02	C
ATOM	101	OG	SER		18	22.615	86.351	−12.178	1.00	44.52	O
ATOM	102	C	SER		18	24.062	89.641	−11.117	1.00	41.56	C
ATOM	103	O	SER		18	25.210	89.664	−10.662	1.00	43.19	O
ATOM	104	N	SER		19	23.506	90.684	−11.725	1.00	40.24	N
ATOM	105	CA	SER		19	24.244	91.921	−11.942	1.00	38.48	C
ATOM	106	CB	SER		19	24.111	92.336	−13.409	1.00	40.39	C
ATOM	107	OG	SER		19	22.750	92.373	−13.801	1.00	39.90	O
ATOM	108	C	SER		19	23.857	93.093	−11.049	1.00	37.97	C
ATOM	109	O	SER		19	24.670	93.990	−10.812	1.00	37.38	O
ATOM	110	N	GLY		20	22.621	93.093	−10.558	1.00	36.80	N
ATOM	111	CA	GLY		20	22.172	94.180	−9.706	1.00	34.71	C
ATOM	112	C	GLY		20	21.658	95.353	−10.526	1.00	34.13	C
ATOM	113	O	GLY		20	21.312	96.407	−9.988	1.00	34.41	O
ATOM	114	N	ARG		21	21.618	95.175	−11.840	1.00	32.30	N
ATOM	115	CA	ARG		21	21.134	96.221	−12.727	1.00	31.06	C
ATOM	116	CB	ARG		21	21.720	96.036	−14.126	1.00	34.35	C
ATOM	117	CG	ARG		21	21.690	97.282	−15.001	1.00	38.19	C
ATOM	118	CD	ARG		21	21.821	96.898	−16.466	1.00	39.57	C
ATOM	119	NE	ARG		21	22.731	95.771	−16.636	1.00	40.48	N
ATOM	120	CZ	ARG		21	22.721	94.950	−17.681	1.00	40.27	C
ATOM	121	NH1	ARG		21	21.849	95.127	−18.668	1.00	37.17	N
ATOM	122	NH2	ARG		21	23.573	93.933	−17.723	1.00	41.07	N
ATOM	123	C	ARG		21	19.617	96.088	−12.786	1.00	28.79	C
ATOM	124	O	ARG		21	19.083	94.977	−12.759	1.00	26.98	O
ATOM	125	N	VAL		22	18.921	97.213	−12.865	1.00	26.13	N
ATOM	126	CA	VAL		22	17.468	97.170	−12.920	1.00	26.11	C
ATOM	127	CB	VAL		22	16.850	98.568	−12.664	1.00	27.26	C
ATOM	128	CG1	VAL		22	17.393	99.149	−11.360	1.00	28.88	C
ATOM	129	CG2	VAL		22	17.148	99.495	−13.826	1.00	26.94	C
ATOM	130	C	VAL		22	16.977	96.665	−14.275	1.00	23.64	C
ATOM	131	O	VAL		22	17.671	96.777	−15.288	1.00	22.42	O
ATOM	132	N	TYR		23	15.782	96.088	−14.280	1.00	23.86	N
ATOM	133	CA	TYR		23	15.173	95.610	−15.511	1.00	23.22	C
ATOM	134	CB	TYR		23	15.587	94.165	−15.816	1.00	23.13	C
ATOM	135	CG	TYR		23	15.010	93.094	−14.918	1.00	24.78	C
ATOM	136	CD1	TYR		23	13.875	92.376	−15.298	1.00	25.93	C
ATOM	137	CE1	TYR		23	13.381	91.339	−14.510	1.00	27.38	C
ATOM	138	CD2	TYR		23	15.634	92.755	−13.719	1.00	27.24	C
ATOM	139	CE2	TYR		23	15.151	91.725	−12.922	1.00	29.04	C
ATOM	140	CZ	TYR		23	14.026	91.019	−13.324	1.00	29.80	C
ATOM	141	OH	TYR		23	13.558	89.990	−12.543	1.00	32.22	O
ATOM	142	C	TYR		23	13.672	95.728	−15.323	1.00	24.27	C
ATOM	143	O	TYR		23	13.213	96.125	−14.250	1.00	23.22	O
ATOM	144	N	TYR		24	12.908	95.407	−16.359	1.00	23.73	N
ATOM	145	CA	TYR		24	11.462	95.509	−16.267	1.00	25.12	C
ATOM	146	CB	TYR		24	10.954	96.574	−17.240	1.00	28.83	C
ATOM	147	CG	TYR		24	11.623	97.908	−17.002	1.00	34.51	C
ATOM	148	CD1	TYR		24	12.932	98.140	−17.433	1.00	35.79	C
ATOM	149	CE1	TYR		24	13.590	99.331	−17.135	1.00	38.57	C
ATOM	150	CD2	TYR		24	10.985	98.908	−16.269	1.00	36.92	C
ATOM	151	CE2	TYR		24	11.635	100.107	−15.965	1.00	39.55	C
ATOM	152	CZ	TYR		24	12.936	100.308	−16.401	1.00	40.27	C
ATOM	153	OH	TYR		24	13.584	101.485	−16.099	1.00	43.04	O
ATOM	154	C	TYR		24	10.802	94.169	−16.526	1.00	23.31	C
ATOM	155	O	TYR		24	11.234	93.405	−17.377	1.00	19.10	O
ATOM	156	N	PHE		25	9.756	93.898	−15.758	1.00	23.61	N
ATOM	157	CA	PHE		25	9.013	92.654	−15.845	1.00	23.90	C
ATOM	158	CB	PHE		25	9.235	91.852	−14.560	1.00	26.26	C
ATOM	159	CG	PHE		25	8.345	90.657	−14.426	1.00	28.41	C
ATOM	160	CD1	PHE		25	8.520	89.542	−15.247	1.00	29.55	C
ATOM	161	CD2	PHE		25	7.317	90.647	−13.485	1.00	29.28	C
ATOM	162	CE1	PHE		25	7.679	88.427	−15.135	1.00	29.82	C
ATOM	163	CE2	PHE		25	6.471	89.540	−13.364	1.00	31.45	C
ATOM	164	CZ	PHE		25	6.654	88.430	−14.194	1.00	30.08	C
ATOM	165	C	PHE		25	7.543	93.013	−15.987	1.00	24.35	C
ATOM	166	O	PHE		25	7.084	94.005	−15.415	1.00	25.24	O
ATOM	167	N	ASN		26	6.815	92.212	−16.756	1.00	23.43	N
ATOM	168	CA	ASN		26	5.385	92.426	−16.971	1.00	22.40	C
ATOM	169	CB	ASN		26	5.094	92.543	−18.471	1.00	21.86	C
ATOM	170	CG	ASN		26	3.644	92.874	−18.760	1.00	20.05	C
ATOM	171	OD1	ASN		26	2.748	92.101	−18.440	1.00	18.93	O
ATOM	172	ND2	ASN		26	3.410	94.029	−19.370	1.00	21.42	N
ATOM	173	C	ASN		26	4.677	91.213	−16.377	1.00	19.54	C
ATOM	174	O	ASN		26	4.905	90.081	−16.805	1.00	18.99	O
ATOM	175	N	HIS		27	3.822	91.439	−15.385	1.00	18.51	N
ATOM	176	CA	HIS		27	3.143	90.323	−14.731	1.00	19.95	C
ATOM	177	CB	HIS		27	2.727	90.719	−13.310	1.00	20.01	C
ATOM	178	CG	HIS		27	1.832	91.916	−13.253	1.00	22.73	C
ATOM	179	CD2	HIS		27	2.101	93.217	−12.995	1.00	24.62	C
ATOM	180	ND1	HIS		27	0.476	91.845	−13.492	1.00	25.87	N
ATOM	181	CE1	HIS		27	−0.052	93.051	−13.384	1.00	27.16	C
ATOM	182	NE2	HIS		27	0.913	93.903	−13.084	1.00	27.76	N
ATOM	183	C	HIS		27	1.944	89.747	−15.480	1.00	19.02	C
ATOM	184	O	HIS		27	1.305	88.817	−14.997	1.00	21.28	O
ATOM	185	N	ILE		28	1.639	90.294	−16.650	1.00	20.60	N
ATOM	186	CA	ILE		28	0.525	89.788	−17.444	1.00	21.05	C
ATOM	187	CB	ILE		28	−0.316	90.935	−18.051	1.00	22.57	C
ATOM	188	CG2	ILE		28	−1.479	90.350	−18.852	1.00	20.76	C
ATOM	189	CG1	ILE		28	−0.835	91.851	−16.942	1.00	22.09	C
ATOM	190	CD1	ILE		28	−1.473	93.137	−17.451	1.00	23.01	C
ATOM	191	C	ILE		28	1.058	88.923	−18.588	1.00	20.36	C
ATOM	192	O	ILE		28	0.490	87.876	−18.897	1.00	21.46	O
ATOM	193	N	THR		29	2.158	89.354	−19.205	1.00	19.41	N
ATOM	194	CA	THR		29	2.749	88.611	−20.322	1.00	18.44	C
ATOM	195	CB	THR		29	3.245	89.548	−21.431	1.00	16.48	C
ATOM	196	OG1	THR		29	4.380	90.277	−20.947	1.00	15.52	O
ATOM	197	CG2	THR		29	2.162	90.528	−21.838	1.00	17.51	C
ATOM	198	C	THR		29	3.954	87.787	−19.892	1.00	17.66	C
ATOM	199	O	THR		29	4.407	86.913	−20.635	1.00	15.04	O
ATOM	200	N	ASN		30	4.469	88.083	−18.699	1.00	18.86	N
ATOM	201	CA	ASN		30	5.646	87.411	−18.150	1.00	19.21	C
ATOM	202	CB	ASN		30	5.418	85.898	−18.075	1.00	18.37	C
ATOM	203	CG	ASN		30	4.631	85.491	−16.828	1.00	21.15	C
ATOM	204	OD1	ASN		30	3.985	84.436	−16.795	1.00	20.51	O
ATOM	205	ND2	ASN		30	4.696	86.325	−15.792	1.00	18.80	N
ATOM	206	C	ASN		30	6.911	87.735	−18.949	1.00	18.18	C
ATOM	207	O	ASN		30	7.920	87.035	−18.857	1.00	18.36	O
ATOM	208	N	ALA		31	6.859	88.797	−19.740	1.00	18.07	N
ATOM	209	CA	ALA		31	8.042	89.188	−20.497	1.00	18.58	C
ATOM	210	CB	ALA		31	7.654	90.066	−21.680	1.00	20.05	C
ATOM	211	C	ALA		31	8.974	89.960	−19.562	1.00	19.63	C
ATOM	212	O	ALA		31	8.538	90.550	−18.561	1.00	19.30	O
ATOM	213	N	SER		32	10.263	89.944	−19.875	1.00	19.74	N
ATOM	214	CA	SER		32	11.231	90.685	−19.082	1.00	20.22	C
ATOM	215	CB	SER		32	11.840	89.801	−17.987	1.00	19.25	C
ATOM	216	OG	SER		32	12.328	88.583	−18.505	1.00	24.38	O
ATOM	217	C	SER		32	12.301	91.219	−20.024	1.00	21.37	C
ATOM	218	O	SER		32	12.672	90.563	−20.996	1.00	21.28	O
ATOM	219	N	GLN		33	12.773	92.429	−19.755	1.00	23.24	N
ATOM	220	CA	GLN		33	13.788	93.034	−20.600	1.00	24.72	C
ATOM	221	CB	GLN		33	13.131	93.645	−21.835	1.00	25.90	C
ATOM	222	CG	GLN		33	12.102	94.722	−21.529	1.00	29.80	C
ATOM	223	CD	GLN		33	11.227	95.046	−22.729	1.00	33.65	C
ATOM	224	OE1	GLN		33	10.470	96.017	−22.718	1.00	34.96	O
ATOM	225	NE2	GLN		33	11.318	94.222	−23.769	1.00	34.57	N
ATOM	226	C	GLN		33	14.551	94.103	−19.834	1.00	25.35	C
ATOM	227	O	GLN		33	14.092	94.576	−18.795	1.00	24.37	O
ATOM	228	N	TRP		34	15.708	94.487	−20.366	1.00	26.89	N
ATOM	229	CA	TRP		34	16.553	95.498	−19.741	1.00	27.75	C
ATOM	230	CB	TRP		34	17.976	95.412	−20.306	1.00	26.26	C
ATOM	231	CG	TRP		34	18.699	94.156	−19.913	1.00	24.74	C
ATOM	232	CD2	TRP		34	19.033	93.739	−18.582	1.00	25.26	C
ATOM	233	CE2	TRP		34	19.695	92.495	−18.687	1.00	26.19	C
ATOM	234	CE3	TRP		34	18.836	94.295	−17.310	1.00	24.96	C
ATOM	235	CD1	TRP		34	19.158	93.179	−20.746	1.00	24.73	C
ATOM	236	NE1	TRP		34	19.758	92.179	−20.019	1.00	26.44	N
ATOM	237	CZ2	TRP		34	20.163	91.792	−17.567	1.00	26.97	C
ATOM	238	CZ3	TRP		34	19.301	93.598	−16.194	1.00	26.62	C
ATOM	239	CH2	TRP		34	19.957	92.358	−16.333	1.00	26.96	C
ATOM	240	C	TRP		34	16.028	96.921	−19.899	1.00	31.05	C
ATOM	241	O	TRP		34	16.115	97.724	−18.969	1.00	29.24	O
ATOM	242	N	GLU		35	15.479	97.240	−21.068	1.00	35.17	N
ATOM	243	CA	GLU		35	14.967	98.587	−21.302	1.00	40.03	C
ATOM	244	CB	GLU		35	14.898	98.890	−22.792	1.00	42.14	C
ATOM	245	CG	GLU		35	16.231	99.024	−23.476	1.00	46.01	C
ATOM	246	CD	GLU		35	16.142	99.926	−24.684	1.00	47.87	C
ATOM	247	OE1	GLU		35	16.985	99.786	−25.593	1.00	49.04	O
ATOM	248	OE2	GLU		35	15.229	100.787	−24.715	1.00	49.18	O
ATOM	249	C	GLU		35	13.601	98.878	−20.707	1.00	43.21	C
ATOM	250	O	GLU		35	12.782	97.981	−20.513	1.00	42.38	O
ATOM	251	N	ARG		36	13.366	100.155	−20.427	1.00	47.08	N
ATOM	252	CA	ARG		36	12.094	100.599	−19.882	1.00	51.80	C
ATOM	253	CB	ARG		36	12.237	101.998	−19.280	1.00	53.12	C
ATOM	254	CG	ARG		36	11.031	102.449	−18.478	1.00	56.83	C
ATOM	255	CD	ARG		36	11.378	103.617	−17.568	1.00	58.92	C
ATOM	256	NE	ARG		36	10.266	103.966	−16.690	1.00	61.98	N
ATOM	257	CZ	ARG		36	10.352	104.816	−15.672	1.00	63.63	C
ATOM	258	NH1	ARG		36	11.506	105.413	−15.398	1.00	65.04	N
ATOM	259	NH2	ARG		36	9.284	105.067	−14.925	1.00	64.32	N
ATOM	260	C	ARG		36	11.134	100.613	−21.065	1.00	53.82	C
ATOM	261	O	ARG		36	11.356	101.323	−22.048	1.00	54.14	O
ATOM	262	N	PRO		37	10.056	99.819	−20.988	1.00	55.67	N
ATOM	263	CD	PRO		37	9.601	99.102	−19.784	1.00	55.91	C
ATOM	264	CA	PRO		37	9.054	99.725	−22.054	1.00	57.14	C
ATOM	265	CB	PRO		37	8.084	98.680	−21.512	1.00	56.96	C
ATOM	266	CG	PRO		37	8.118	98.949	−20.044	1.00	56.31	C
ATOM	267	C	PRO		37	8.358	101.037	−22.407	1.00	58.98	C
ATOM	268	O	PRO		37	8.079	101.864	−21.532	1.00	58.84	O
ATOM	269	N	SER		38	8.080	101.209	−23.699	1.00	60.46	N
ATOM	270	CA	SER		38	7.403	102.396	−24.220	1.00	62.00	C
ATOM	271	CB	SER		38	5.886	102.205	−24.140	1.00	62.10	C
ATOM	272	OG	SER		38	5.496	100.982	−24.740	1.00	62.82	O
ATOM	273	C	SER		38	7.797	103.672	−23.480	1.00	62.50	C
ATOM	274	O	SER		38	6.987	104.257	−22.757	1.00	63.00	O
ATOM	275	N	GLU		51	−7.299	100.145	−25.882	1.00	54.73	N
ATOM	276	CA	GLU		51	−6.547	99.038	−26.459	1.00	54.16	C
ATOM	277	CB	GLU		51	−6.525	97.850	−25.492	1.00	53.49	C
ATOM	278	CG	GLU		51	−7.802	97.023	−25.496	1.00	52.61	C
ATOM	279	CD	GLU		51	−7.781	95.896	−24.480	1.00	51.66	C
ATOM	280	OE1	GLU		51	−8.699	95.054	−24.519	1.00	51.27	O
ATOM	281	OE2	GLU		51	−6.855	95.854	−23.640	1.00	50.71	O
ATOM	282	C	GLU		51	−7.195	98.617	−27.776	1.00	54.07	C
ATOM	283	O	GLU		51	−8.335	98.989	−28.063	1.00	54.46	O
ATOM	284	N	PRO		52	−6.474	97.833	−28.597	1.00	53.57	N
ATOM	285	CD	PRO		52	−5.070	97.415	−28.447	1.00	53.61	C
ATOM	286	CA	PRO		52	−7.014	97.378	−29.883	1.00	51.72	C
ATOM	287	CB	PRO		52	−5.853	96.590	−30.488	1.00	52.84	C
ATOM	288	CG	PRO		52	−4.646	97.240	−29.881	1.00	53.98	C
ATOM	289	C	PRO		52	−8.252	96.505	−29.699	1.00	49.84	C
ATOM	290	O	PRO		52	−8.416	95.855	−28.666	1.00	49.91	O
ATOM	291	N	ALA		53	−9.118	96.498	−30.706	1.00	46.77	N
ATOM	292	CA	ALA		53	−10.330	95.694	−30.665	1.00	43.86	C
ATOM	293	CB	ALA		53	−11.320	96.185	−31.712	1.00	44.36	C
ATOM	294	C	ALA		53	−9.933	94.256	−30.956	1.00	41.48	C
ATOM	295	O	ALA		53	−10.553	93.312	−30.465	1.00	39.69	O
ATOM	296	N	ARG		54	−8.883	94.104	−31.758	1.00	39.02	N
ATOM	297	CA	ARG		54	−8.384	92.789	−32.138	1.00	36.56	C
ATOM	298	CB	ARG		54	−8.983	92.369	−33.485	1.00	39.18	C
ATOM	299	CG	ARG		54	−10.502	92.387	−33.539	1.00	42.60	C
ATOM	300	CD	ARG		54	−11.011	92.344	−34.979	1.00	44.45	C
ATOM	301	NE	ARG		54	−10.748	91.071	−35.645	1.00	46.01	N
ATOM	302	CZ	ARG		54	−11.250	89.904	−35.253	1.00	48.61	C
ATOM	303	NH1	ARG		54	−12.044	89.842	−34.190	1.00	49.20	N
ATOM	304	NH2	ARG		54	−10.972	88.797	−35.933	1.00	48.94	N
ATOM	305	C	ARG		54	−6.863	92.790	−32.259	1.00	33.22	C
ATOM	306	O	ARG		54	−6.243	93.821	−32.525	1.00	31.35	O
ATOM	307	N	VAL		55	−6.269	91.623	−32.048	1.00	29.61	N
ATOM	308	CA	VAL		55	−4.828	91.461	−32.178	1.00	26.44	C
ATOM	309	CB	VAL		55	−4.104	91.355	−30.801	1.00	25.08	C
ATOM	310	CG1	VAL		55	−4.372	92.595	−29.966	1.00	24.38	C
ATOM	311	CG2	VAL		55	−4.559	90.100	−30.065	1.00	25.34	C
ATOM	312	C	VAL		55	−4.625	90.151	−32.910	1.00	25.04	C
ATOM	313	O	VAL		55	−5.523	89.308	−32.947	1.00	24.96	O
ATOM	314	N	ARG		56	−3.454	89.988	−33.511	1.00	22.94	N
ATOM	315	CA	ARG		56	−3.127	88.755	−34.202	1.00	21.84	C
ATOM	316	CB	ARG		56	−2.846	89.023	−35.683	1.00	22.77	C
ATOM	317	CG	ARG		56	−2.554	87.763	−36.478	1.00	24.73	C
ATOM	318	CD	ARG		56	−2.221	88.070	−37.934	1.00	24.89	C
ATOM	319	NE	ARG		56	−1.982	86.848	−38.696	1.00	27.57	N
ATOM	320	CZ	ARG		56	−1.732	86.819	−40.000	1.00	30.02	C
ATOM	321	NH1	ARG		56	−1.688	87.950	−40.692	1.00	28.85	N
ATOM	322	NH2	ARG		56	−1.528	85.660	−40.614	1.00	29.59	N
ATOM	323	C	ARG		56	−1.877	88.204	−33.521	1.00	20.99	C
ATOM	324	O	ARG		56	−0.914	88.940	−33.299	1.00	19.81	O
ATOM	325	N	CYS		57	−1.896	86.920	−33.177	1.00	19.41	N
ATOM	326	CA	CYS		57	−0.745	86.304	−32.521	1.00	19.30	C
ATOM	327	CB	CYS		57	−0.989	86.145	−31.012	1.00	18.77	C
ATOM	328	SG	CYS		57	−1.263	87.657	−30.087	1.00	19.47	S
ATOM	329	C	CYS		57	−0.417	84.933	−33.060	1.00	19.50	C
ATOM	330	O	CYS		57	−1.250	84.267	−33.675	1.00	20.50	O
ATOM	331	N	SER		58	0.822	84.524	−32.825	1.00	17.55	N
ATOM	332	CA	SER		58	1.286	83.196	−33.173	1.00	17.69	C
ATOM	333	CB	SER		58	2.499	83.242	−34.108	1.00	18.00	C
ATOM	334	OG	SER		58	2.137	83.702	−35.390	1.00	18.64	O
ATOM	335	C	SER		58	1.725	82.697	−31.805	1.00	18.37	C
ATOM	336	O	SER		58	1.940	83.503	−30.889	1.00	18.47	O
ATOM	337	N	HIS		59	1.850	81.390	−31.641	1.00	17.51	N
ATOM	338	CA	HIS		59	2.294	80.872	−30.360	1.00	17.57	C
ATOM	339	CB	HIS		59	1.118	80.810	−29.359	1.00	18.76	C
ATOM	340	CG	HIS		59	0.260	79.587	−29.488	1.00	20.38	C
ATOM	341	CD2	HIS		59	−0.139	78.681	−28.564	1.00	20.36	C
ATOM	342	ND1	HIS		59	−0.312	79.194	−30.680	1.00	22.08	N
ATOM	343	CE1	HIS		59	−1.025	78.097	−30.485	1.00	20.02	C
ATOM	344	NE2	HIS		59	−0.937	77.766	−29.210	1.00	24.12	N
ATOM	345	C	HIS		59	2.955	79.508	−30.501	1.00	17.86	C
ATOM	346	O	HIS		59	2.825	78.829	−31.526	1.00	16.44	O
ATOM	347	N	LEU		60	3.701	79.133	−29.474	1.00	17.48	N
ATOM	348	CA	LEU		60	4.367	77.847	−29.436	1.00	18.71	C
ATOM	349	CB	LEU		60	5.887	78.023	−29.382	1.00	17.85	C
ATOM	350	CG	LEU		60	6.736	76.753	−29.516	1.00	17.50	C
ATOM	351	CD1	LEU		60	8.168	77.146	−29.868	1.00	18.29	C
ATOM	352	CD2	LEU		60	6.697	75.945	−28.225	1.00	17.89	C
ATOM	353	C	LEU		60	3.854	77.248	−28.133	1.00	21.30	C
ATOM	354	O	LEU		60	4.044	77.824	−27.058	1.00	20.24	O
ATOM	355	N	LEU		61	3.185	76.108	−28.236	1.00	20.45	N
ATOM	356	CA	LEU		61	2.624	75.448	−27.065	1.00	20.60	C
ATOM	357	CB	LEU		61	1.149	75.089	−27.308	1.00	21.94	C
ATOM	358	CG	LEU		61	0.511	74.157	−26.263	1.00	21.71	C
ATOM	359	CD1	LEU		61	0.524	74.838	−24.897	1.00	22.57	C
ATOM	360	CD2	LEU		61	−0.915	73.803	−26.665	1.00	21.58	C
ATOM	361	C	LEU		61	3.377	74.184	−26.700	1.00	19.71	C
ATOM	362	O	LEU		61	3.672	73.352	−27.556	1.00	18.48	O
ATOM	363	N	VAL		62	3.710	74.064	−25.421	1.00	20.78	N
ATOM	364	CA	VAL		62	4.372	72.874	−24.928	1.00	21.01	C
ATOM	365	CB	VAL		62	5.713	73.180	−24.260	1.00	21.01	C
ATOM	366	CG1	VAL		62	6.249	71.917	−23.593	1.00	22.48	C
ATOM	367	CG2	VAL		62	6.702	73.672	−25.303	1.00	20.98	C
ATOM	368	C	VAL		62	3.405	72.316	−23.898	1.00	23.01	C
ATOM	369	O	VAL		62	3.182	72.919	−22.845	1.00	20.35	O
ATOM	370	N	LYS		63	2.795	71.185	−24.234	1.00	22.70	N
ATOM	371	CA	LYS		63	1.843	70.554	−23.338	1.00	25.68	C
ATOM	372	CB	LYS		63	0.885	69.656	−24.131	1.00	26.95	C
ATOM	373	CG	LYS		63	−0.159	70.406	−24.942	1.00	29.77	C
ATOM	374	CD	LYS		63	−1.162	69.434	−25.566	1.00	31.46	C
ATOM	375	CE	LYS		63	−2.341	70.168	−26.180	1.00	32.39	C
ATOM	376	NZ	LYS		63	−3.356	69.215	−26.717	1.00	32.43	N
ATOM	377	C	LYS		63	2.570	69.720	−22.295	1.00	26.46	C
ATOM	378	O	LYS		63	3.765	69.439	−22.424	1.00	25.58	O
ATOM	379	N	HIS		64	1.839	69.343	−21.252	1.00	27.05	N
ATOM	380	CA	HIS		64	2.378	68.508	−20.189	1.00	28.81	C
ATOM	381	CB	HIS		64	2.920	69.364	−19.035	1.00	26.98	C
ATOM	382	CG	HIS		64	1.959	70.395	−18.535	1.00	28.06	C
ATOM	383	CD2	HIS		64	1.994	71.748	−18.597	1.00	27.80	C
ATOM	384	ND1	HIS		64	0.795	70.072	−17.871	1.00	27.74	N
ATOM	385	CE1	HIS		64	0.155	71.181	−17.546	1.00	30.15	C
ATOM	386	NE2	HIS		64	0.861	72.212	−17.975	1.00	29.96	N
ATOM	387	C	HIS		64	1.272	67.571	−19.699	1.00	30.37	C
ATOM	388	O	HIS		64	0.114	67.695	−20.113	1.00	29.45	O
ATOM	389	N	SER		65	1.633	66.640	−18.821	1.00	31.38	N
ATOM	390	CA	SER		65	0.683	65.660	−18.305	1.00	31.46	C
ATOM	391	CB	SER		65	1.375	64.753	−17.287	1.00	32.89	C
ATOM	392	OG	SER		65	1.779	65.486	−16.147	1.00	35.80	O
ATOM	393	C	SER		65	−0.606	66.225	−17.704	1.00	31.05	C
ATOM	394	O	SER		65	−1.604	65.513	−17.621	1.00	31.26	O
ATOM	395	N	GLN		66	−0.607	67.487	−17.283	1.00	29.89	N
ATOM	396	CA	GLN		66	−1.825	68.065	−16.716	1.00	29.89	C
ATOM	397	CB	GLN		66	−1.513	68.887	−15.455	1.00	31.36	C
ATOM	398	CG	GLN		66	−1.179	68.040	−14.229	1.00	32.82	C
ATOM	399	CD	GLN		66	−1.109	68.855	−12.943	1.00	36.67	C
ATOM	400	OE1	GLN		66	−2.117	69.400	−12.478	1.00	33.97	O
ATOM	401	NE2	GLN		66	0.087	68.941	−12.362	1.00	36.73	N
ATOM	402	C	GLN		66	−2.633	68.915	−17.700	1.00	30.12	C
ATOM	403	O	GLN		66	−3.586	69.590	−17.305	1.00	31.23	O
ATOM	404	N	SER		67	−2.250	68.896	−18.975	1.00	30.74	N
ATOM	405	CA	SER		67	−2.990	69.643	−19.992	1.00	32.03	C
ATOM	406	CB	SER		67	−2.228	69.644	−21.323	1.00	31.44	C
ATOM	407	OG	SER		67	−0.987	70.325	−21.217	1.00	28.66	O
ATOM	408	C	SER		67	−4.326	68.917	−20.166	1.00	33.77	C
ATOM	409	O	SER		67	−4.360	67.687	−20.114	1.00	33.93	O
ATOM	410	N	ARG		68	−5.415	69.663	−20.365	1.00	35.93	N
ATOM	411	CA	ARG		68	−6.733	69.044	−20.534	1.00	37.58	C
ATOM	412	CB	ARG		68	−7.733	70.021	−21.160	1.00	39.33	C
ATOM	413	CG	ARG		68	−8.167	71.164	−20.257	1.00	43.86	C
ATOM	414	CD	ARG		68	−8.673	70.656	−18.911	1.00	47.04	C
ATOM	415	NE	ARG		68	−9.133	71.746	−18.053	1.00	48.93	N
ATOM	416	CZ	ARG		68	−9.237	71.660	−16.730	1.00	50.45	C
ATOM	417	NH1	ARG		68	−8.909	70.533	−16.108	1.00	50.38	N
ATOM	418	NH2	ARG		68	−9.669	72.699	−16.028	1.00	50.61	N
ATOM	419	C	ARG		68	−6.634	67.806	−21.412	1.00	38.24	C
ATOM	420	O	ARG		68	−7.174	66.748	−21.083	1.00	37.80	O
ATOM	421	N	ARG		69	−5.935	67.947	−22.531	1.00	37.54	N
ATOM	422	CA	ARG		69	−5.748	66.848	−23.463	1.00	37.33	C
ATOM	423	CB	ARG		69	−6.429	67.180	−24.791	1.00	40.02	C
ATOM	424	CG	ARG		69	−6.077	66.241	−25.928	1.00	45.02	C
ATOM	425	CD	ARG		69	−6.171	66.979	−27.253	1.00	49.84	C
ATOM	426	NE	ARG		69	−5.460	66.301	−28.333	1.00	52.65	N
ATOM	427	CZ	ARG		69	−5.140	66.880	−29.488	1.00	54.87	C
ATOM	428	NH1	ARG		69	−5.467	68.149	−29.707	1.00	54.97	N
ATOM	429	NH2	ARG		69	−4.497	66.192	−30.426	1.00	56.36	N
ATOM	430	C	ARG		69	−4.249	66.602	−23.678	1.00	36.57	C
ATOM	431	O	ARG		69	−3.626	67.208	−24.557	1.00	35.67	O
ATOM	432	N	PRO		70	−3.650	65.712	−22.869	1.00	34.72	N
ATOM	433	CD	PRO		70	−4.261	64.994	−21.736	1.00	35.36	C
ATOM	434	CA	PRO		70	−2.222	65.393	−22.977	1.00	33.32	C
ATOM	435	CB	PRO		70	−1.953	64.587	−21.707	1.00	34.34	C
ATOM	436	CG	PRO		70	−3.258	63.895	−21.473	1.00	34.73	C
ATOM	437	C	PRO		70	−1.855	64.632	−24.250	1.00	31.63	C
ATOM	438	O	PRO		70	−1.309	63.528	−24.198	1.00	31.57	O
ATOM	439	N	SER		71	−2.143	65.245	−25.395	1.00	30.37	N
ATOM	440	CA	SER		71	−1.854	64.642	−26.693	1.00	29.01	C
ATOM	441	CB	SER		71	−2.974	63.665	−27.076	1.00	29.15	C
ATOM	442	OG	SER		71	−2.685	62.990	−28.291	1.00	31.24	O
ATOM	443	C	SER		71	−1.765	65.740	−27.748	1.00	27.74	C
ATOM	444	O	SER		71	−2.376	66.799	−27.590	1.00	28.29	O
ATOM	445	N	SER		72	−1.004	65.484	−28.811	1.00	26.64	N
ATOM	446	CA	SER		72	−0.853	66.440	−29.914	1.00	27.23	C
ATOM	447	CB	SER		72	0.118	67.566	−29.542	1.00	26.09	C
ATOM	448	OG	SER		72	1.460	67.121	−29.657	1.00	20.71	O
ATOM	449	C	SER		72	−0.312	65.721	−31.141	1.00	27.44	C
ATOM	450	O	SER		72	0.033	64.544	−31.075	1.00	27.06	O
ATOM	451	N	TRP		73	−0.216	66.439	−32.257	1.00	28.05	N
ATOM	452	CA	TRP		73	0.296	65.852	−33.487	1.00	27.76	C
ATOM	453	CB	TRP		73	0.212	66.861	−34.643	1.00	28.27	C
ATOM	454	CG	TRP		73	1.202	67.995	−34.531	1.00	27.03	C
ATOM	455	CD2	TRP		73	2.547	68.010	−35.032	1.00	26.83	C
ATOM	456	CE2	TRP		73	3.122	69.246	−34.652	1.00	24.67	C
ATOM	457	CE3	TRP		73	3.324	67.097	−35.761	1.00	26.46	C
ATOM	458	CD1	TRP		73	1.020	69.190	−33.888	1.00	26.62	C
ATOM	459	NE1	TRP		73	2.170	69.945	−33.957	1.00	24.81	N
ATOM	460	CZ2	TRP		73	4.438	69.592	−34.978	1.00	24.97	C
ATOM	461	CZ3	TRP		73	4.638	67.444	−36.084	1.00	28.24	C
ATOM	462	CH2	TRP		73	5.179	68.682	−35.691	1.00	25.90	C
ATOM	463	C	TRP		73	1.746	65.392	−33.317	1.00	27.65	C
ATOM	464	O	TRP		73	2.247	64.610	−34.118	1.00	27.77	O
ATOM	465	N	ARG		74	2.422	65.877	−32.278	1.00	28.75	N
ATOM	466	CA	ARG		74	3.814	65.494	−32.047	1.00	29.62	C
ATOM	467	CB	ARG		74	4.542	66.550	−31.210	1.00	28.45	C
ATOM	468	CG	ARG		74	4.584	67.929	−31.836	1.00	29.77	C
ATOM	469	CD	ARG		74	5.736	68.725	−31.251	1.00	28.83	C
ATOM	470	NE	ARG		74	7.003	68.086	−31.582	1.00	28.53	N
ATOM	471	CZ	ARG		74	7.992	67.881	−30.720	1.00	30.40	C
ATOM	472	NH1	ARG		74	7.869	68.267	−29.456	1.00	31.01	N
ATOM	473	NH2	ARG		74	9.105	67.284	−31.128	1.00	30.12	N
ATOM	474	C	ARG		74	3.946	64.142	−31.359	1.00	30.21	C
ATOM	475	O	ARG		74	4.894	63.402	−31.616	1.00	30.04	O
ATOM	476	N	GLN		75	3.016	63.837	−30.462	1.00	30.70	N
ATOM	477	CA	GLN		75	3.026	62.556	−29.766	1.00	32.11	C
ATOM	478	CB	GLN		75	4.120	62.508	−28.691	1.00	34.24	C
ATOM	479	CG	GLN		75	4.043	63.587	−27.644	1.00	38.32	C
ATOM	480	CD	GLN		75	5.032	63.366	−26.511	1.00	40.81	C
ATOM	481	OE1	GLN		75	5.206	64.227	−25.648	1.00	41.30	O
ATOM	482	NE2	GLN		75	5.679	62.205	−26.504	1.00	41.57	N
ATOM	483	C	GLN		75	1.657	62.280	−29.159	1.00	31.47	C
ATOM	484	O	GLN		75	1.046	63.145	−28.527	1.00	29.42	O
ATOM	485	N	GLU		76	1.185	61.059	−29.375	1.00	31.28	N
ATOM	486	CA	GLU		76	−0.125	60.630	−28.912	1.00	30.49	C
ATOM	487	CB	GLU		76	−0.372	59.195	−29.381	1.00	30.39	C
ATOM	488	CG	GLU		76	−1.828	58.780	−29.381	1.00	30.82	C
ATOM	489	CD	GLU		76	−2.078	57.547	−30.233	1.00	31.41	C
ATOM	490	OE1	GLU		76	−3.260	57.178	−30.405	1.00	32.43	O
ATOM	491	OE2	GLU		76	−1.099	56.953	−30.732	1.00	28.34	O
ATOM	492	C	GLU		76	−0.331	60.738	−27.405	1.00	31.28	C
ATOM	493	O	GLU		76	−1.391	61.170	−26.948	1.00	29.48	O
ATOM	494	N	LYS		77	0.684	60.354	−26.637	1.00	32.54	N
ATOM	495	CA	LYS		77	0.606	60.395	−25.179	1.00	34.50	C
ATOM	496	CB	LYS		77	0.798	58.979	−24.620	1.00	35.38	C
ATOM	497	CG	LYS		77	0.761	58.868	−23.101	1.00	37.93	C
ATOM	498	CD	LYS		77	−0.646	59.047	−22.551	1.00	39.29	C
ATOM	499	CE	LYS		77	−0.688	58.791	−21.048	1.00	39.81	C
ATOM	500	NZ	LYS		77	−0.155	57.439	−20.697	1.00	40.40	N
ATOM	501	C	LYS		77	1.664	61.330	−24.584	1.00	34.14	C
ATOM	502	O	LYS		77	2.823	60.945	−24.441	1.00	33.98	O
ATOM	503	N	ILE		78	1.261	62.552	−24.243	1.00	33.79	N
ATOM	504	CA	ILE		78	2.176	63.532	−23.651	1.00	34.37	C
ATOM	505	CB	ILE		78	1.596	64.964	−23.722	1.00	34.17	C
ATOM	506	CG2	ILE		78	2.588	65.956	−23.106	1.00	33.11	C
ATOM	507	CG1	ILE		78	1.257	65.335	−25.172	1.00	35.39	C
ATOM	508	CD1	ILE		78	2.433	65.768	−26.010	1.00	35.38	C
ATOM	509	C	ILE		78	2.363	63.176	−22.175	1.00	34.21	C
ATOM	510	O	ILE		78	1.407	63.220	−21.402	1.00	33.74	O
ATOM	511	N	THR		79	3.587	62.847	−21.776	1.00	34.52	N
ATOM	512	CA	THR		79	3.839	62.469	−20.390	1.00	35.59	C
ATOM	513	CB	THR		79	4.379	61.034	−20.325	1.00	36.73	C
ATOM	514	OG1	THR		79	5.616	60.955	−21.041	1.00	37.76	O
ATOM	515	CG2	THR		79	3.384	60.073	−20.949	1.00	38.34	C
ATOM	516	C	THR		79	4.780	63.378	−19.588	1.00	35.57	C
ATOM	517	O	THR		79	4.954	63.176	−18.385	1.00	35.59	O
ATOM	518	N	ARG		80	5.385	64.369	−20.239	1.00	33.23	N
ATOM	519	CA	ARG		80	6.296	65.279	−19.541	1.00	30.67	C
ATOM	520	CB	ARG		80	6.904	66.287	−20.528	1.00	31.47	C
ATOM	521	CG	ARG		80	5.882	67.267	−21.098	1.00	34.41	C
ATOM	522	CD	ARG		80	6.529	68.381	−21.915	1.00	35.34	C
ATOM	523	NE	ARG		80	6.316	68.205	−23.349	1.00	39.31	N
ATOM	524	CZ	ARG		80	7.139	67.541	−24.148	1.00	38.61	C
ATOM	525	NH1	ARG		80	8.240	66.989	−23.652	1.00	42.07	N
ATOM	526	NH2	ARG		80	6.863	67.425	−25.440	1.00	36.80	N
ATOM	527	C	ARG		80	5.557	66.039	−18.439	1.00	28.66	C
ATOM	528	O	ARG		80	4.371	66.341	−18.570	1.00	28.06	O
ATOM	529	N	THR		81	6.260	66.353	−17.356	1.00	27.99	N
ATOM	530	CA	THR		81	5.662	67.093	−16.249	1.00	28.26	C
ATOM	531	CB	THR		81	6.500	66.949	−14.965	1.00	29.49	C
ATOM	532	OG1	THR		81	7.796	67.530	−15.168	1.00	29.06	O
ATOM	533	CG2	THR		81	6.665	65.476	−14.601	1.00	30.46	C
ATOM	534	C	THR		81	5.587	68.575	−16.605	1.00	28.36	C
ATOM	535	O	THR		81	6.197	69.011	−17.583	1.00	27.32	O
ATOM	536	N	LYS		82	4.842	69.347	−15.819	1.00	28.42	N
ATOM	537	CA	LYS		82	4.735	70.782	−16.069	1.00	30.70	C
ATOM	538	CB	LYS		82	3.819	71.465	−15.053	1.00	33.39	C
ATOM	539	CG	LYS		82	2.406	70.926	−14.977	1.00	40.16	C
ATOM	540	CD	LYS		82	1.455	71.969	−14.381	1.00	43.22	C
ATOM	541	CE	LYS		82	1.969	72.541	−13.060	1.00	44.12	C
ATOM	542	NZ	LYS		82	1.095	73.646	−12.571	1.00	43.54	N
ATOM	543	C	LYS		82	6.119	71.411	−15.950	1.00	29.51	C
ATOM	544	O	LYS		82	6.466	72.318	−16.703	1.00	27.50	O
ATOM	545	N	GLU		83	6.902	70.926	−14.990	1.00	28.04	N
ATOM	546	CA	GLU		83	8.238	71.453	−14.769	1.00	27.05	C
ATOM	547	CB	GLU		83	8.832	70.851	−13.492	1.00	30.17	C
ATOM	548	CG	GLU		83	8.111	71.299	−12.215	1.00	33.55	C
ATOM	549	CD	GLU		83	6.737	70.652	−12.033	1.00	36.81	C
ATOM	550	OE1	GLU		83	5.954	71.139	−11.186	1.00	37.96	O
ATOM	551	OE2	GLU		83	6.445	69.652	−12.723	1.00	37.01	O
ATOM	552	C	GLU		83	9.166	71.225	−15.960	1.00	25.77	C
ATOM	553	O	GLU		83	9.948	72.107	−16.312	1.00	24.44	O
ATOM	554	N	GLU		84	9.081	70.052	−16.583	1.00	25.03	N
ATOM	555	CA	GLU		84	9.911	69.748	−17.747	1.00	25.28	C
ATOM	556	CB	GLU		84	9.796	68.271	−18.122	1.00	27.06	C
ATOM	557	CG	GLU		84	10.215	67.306	−17.034	1.00	31.15	C
ATOM	558	CD	GLU		84	10.035	65.862	−17.453	1.00	32.30	C
ATOM	559	OE1	GLU		84	8.886	65.468	−17.747	1.00	32.10	O
ATOM	560	OE2	GLU		84	11.041	65.125	−17.495	1.00	34.89	O
ATOM	561	C	GLU		84	9.435	70.600	−18.928	1.00	25.79	C
ATOM	562	O	GLU		84	10.232	71.041	−19.763	1.00	24.81	O
ATOM	563	N	ALA		85	8.128	70.818	−18.994	1.00	22.77	N
ATOM	564	CA	ALA		85	7.548	71.627	−20.057	1.00	23.79	C
ATOM	565	CB	ALA		85	6.021	71.610	−19.959	1.00	24.47	C
ATOM	566	C	ALA		85	8.065	73.061	−19.947	1.00	22.66	C
ATOM	567	O	ALA		85	8.398	73.691	−20.956	1.00	20.48	O
ATOM	568	N	LEU		86	8.132	73.577	−18.721	1.00	21.24	N
ATOM	569	CA	LEU		86	8.613	74.940	−18.522	1.00	21.45	C
ATOM	570	CB	LEU		86	8.435	75.379	−17.065	1.00	20.41	C
ATOM	571	CG	LEU		86	8.900	76.812	−16.745	1.00	22.39	C
ATOM	572	CD1	LEU		86	8.232	77.800	−17.706	1.00	19.64	C
ATOM	573	CD2	LEU		86	8.549	77.165	−15.302	1.00	21.24	C
ATOM	574	C	LEU		86	10.082	75.056	−18.923	1.00	22.20	C
ATOM	575	O	LEU		86	10.502	76.087	−19.451	1.00	21.40	O
ATOM	576	N	GLU		87	10.864	74.008	−18.677	1.00	22.64	N
ATOM	577	CA	GLU		87	12.275	74.051	−19.047	1.00	25.14	C
ATOM	578	CB	GLU		87	13.045	72.872	−18.446	1.00	27.52	C
ATOM	579	CG	GLU		87	13.351	73.092	−16.974	1.00	36.19	C
ATOM	580	CD	GLU		87	13.825	74.520	−16.705	1.00	40.59	C
ATOM	581	OE1	GLU		87	14.907	74.901	−17.208	1.00	41.45	O
ATOM	582	OE2	GLU		87	13.105	75.266	−16.001	1.00	43.32	O
ATOM	583	C	GLU		87	12.456	74.081	−20.550	1.00	24.48	C
ATOM	584	O	GLU		87	13.384	74.719	−21.056	1.00	23.19	O
ATOM	585	N	LEU		88	11.576	73.383	−21.263	1.00	21.62	N
ATOM	586	CA	LEU		88	11.626	73.358	−22.717	1.00	20.50	C
ATOM	587	CB	LEU		88	10.607	72.355	−23.266	1.00	20.97	C
ATOM	588	CG	LEU		88	11.000	70.885	−23.100	1.00	23.42	C
ATOM	589	CD1	LEU		88	9.818	69.973	−23.410	1.00	22.75	C
ATOM	590	CD2	LEU		88	12.178	70.584	−24.015	1.00	23.67	C
ATOM	591	C	LEU		88	11.302	74.759	−23.220	1.00	20.27	C
ATOM	592	O	LEU		88	12.004	75.303	−24.084	1.00	19.12	O
ATOM	593	N	ILE		89	10.235	75.338	−22.670	1.00	18.57	N
ATOM	594	CA	ILE		89	9.807	76.680	−23.034	1.00	18.06	C
ATOM	595	CB	ILE		89	8.563	77.104	−22.213	1.00	18.18	C
ATOM	596	CG2	ILE		89	8.399	78.612	−22.244	1.00	15.52	C
ATOM	597	CG1	ILE		89	7.307	76.412	−22.755	1.00	19.04	C
ATOM	598	CD1	ILE		89	6.773	76.998	−24.070	1.00	20.49	C
ATOM	599	C	ILE		89	10.938	77.689	−22.786	1.00	18.48	C
ATOM	600	O	ILE		89	11.253	78.509	−23.655	1.00	17.54	O
ATOM	601	N	ASN		90	11.543	77.635	−21.601	1.00	17.17	N
ATOM	602	CA	ASN		90	12.626	78.562	−21.279	1.00	17.98	C
ATOM	603	CB	ASN		90	13.153	78.321	−19.862	1.00	19.03	C
ATOM	604	CG	ASN		90	12.175	78.766	−18.792	1.00	21.48	C
ATOM	605	OD1	ASN		90	11.453	79.751	−18.963	1.00	24.53	O
ATOM	606	ND2	ASN		90	12.163	78.055	−17.670	1.00	23.45	N
ATOM	607	C	ASN		90	13.767	78.432	−22.277	1.00	17.36	C
ATOM	608	O	ASN		90	14.382	79.428	−22.652	1.00	17.80	O
ATOM	609	N	GLY		91	14.035	77.203	−22.712	1.00	16.95	N
ATOM	610	CA	GLY		91	15.096	76.966	−23.676	1.00	17.04	C
ATOM	611	C	GLY		91	14.778	77.566	−25.037	1.00	17.94	C
ATOM	612	O	GLY		91	15.658	78.119	−25.705	1.00	17.19	O
ATOM	613	N	TYR		92	13.523	77.456	−25.465	1.00	16.53	N
ATOM	614	CA	TYR		92	13.122	78.014	−26.751	1.00	16.32	C
ATOM	615	CB	TYR		92	11.684	77.609	−27.094	1.00	17.49	C
ATOM	616	CG	TYR		92	11.478	76.126	−27.298	1.00	18.42	C
ATOM	617	CD1	TYR		92	10.278	75.518	−26.928	1.00	19.25	C
ATOM	618	CE1	TYR		92	10.078	74.147	−27.108	1.00	21.14	C
ATOM	619	CD2	TYR		92	12.474	75.330	−27.861	1.00	19.07	C
ATOM	620	CE2	TYR		92	12.283	73.960	−28.045	1.00	20.77	C
ATOM	621	CZ	TYR		92	11.082	73.380	−27.665	1.00	21.45	C
ATOM	622	OH	TYR		92	10.886	72.029	−27.844	1.00	22.71	O
ATOM	623	C	TYR		92	13.216	79.535	−26.695	1.00	14.77	C
ATOM	624	O	TYR		92	13.644	80.168	−27.658	1.00	16.96	O
ATOM	625	N	ILE		93	12.809	80.114	−25.568	1.00	14.47	N
ATOM	626	CA	ILE		93	12.863	81.562	−25.405	1.00	15.25	C
ATOM	627	CB	ILE		93	12.247	82.006	−24.047	1.00	14.64	C
ATOM	628	CG2	ILE		93	12.527	83.496	−23.788	1.00	15.01	C
ATOM	629	CG1	ILE		93	10.729	81.796	−24.079	1.00	16.02	C
ATOM	630	CD1	ILE		93	10.044	82.061	−22.748	1.00	18.29	C
ATOM	631	C	ILE		93	14.317	82.030	−25.505	1.00	15.51	C
ATOM	632	O	ILE		93	14.607	83.052	−26.132	1.00	13.31	O
ATOM	633	N	GLN		94	15.235	81.275	−24.912	1.00	15.38	N
ATOM	634	CA	GLN		94	16.638	81.661	−24.985	1.00	18.01	C
ATOM	635	CB	GLN		94	17.501	80.744	−24.115	1.00	19.58	C
ATOM	636	CG	GLN		94	17.278	80.938	−22.623	1.00	23.64	C
ATOM	637	CD	GLN		94	18.292	80.188	−21.783	1.00	28.98	C
ATOM	638	OE1	GLN		94	18.396	78.963	−21.861	1.00	31.96	O
ATOM	639	NE2	GLN		94	19.052	80.923	−20.975	1.00	32.15	N
ATOM	640	C	GLN		94	17.153	81.653	−26.424	1.00	18.29	C
ATOM	641	O	GLN		94	17.815	82.600	−26.853	1.00	19.01	O
ATOM	642	N	LYS		95	16.841	80.598	−27.172	1.00	18.45	N
ATOM	643	CA	LYS		95	17.299	80.503	−28.551	1.00	19.26	C
ATOM	644	CB	LYS		95	17.004	79.110	−29.123	1.00	23.20	C
ATOM	645	CG	LYS		95	17.671	77.964	−28.369	1.00	28.97	C
ATOM	646	CD	LYS		95	17.534	76.647	−29.138	1.00	31.86	C
ATOM	647	CE	LYS		95	17.704	75.420	−28.231	1.00	36.09	C
ATOM	648	NZ	LYS		95	16.525	75.174	−27.315	1.00	33.67	N
ATOM	649	C	LYS		95	16.642	81.569	−29.421	1.00	18.07	C
ATOM	650	O	LYS		95	17.231	82.049	−30.393	1.00	18.02	O
ATOM	651	N	ILE		96	15.416	81.940	−29.077	1.00	15.70	N
ATOM	652	CA	ILE		96	14.715	82.959	−29.842	1.00	16.11	C
ATOM	653	CB	ILE		96	13.207	82.991	−29.478	1.00	16.36	C
ATOM	654	CG2	ILE		96	12.548	84.239	−30.062	1.00	15.55	C
ATOM	655	CG1	ILE		96	12.530	81.718	−30.004	1.00	16.10	C
ATOM	656	CD1	ILE		96	11.063	81.562	−29.591	1.00	21.90	C
ATOM	657	C	ILE		96	15.345	84.323	−29.572	1.00	15.27	C
ATOM	658	O	ILE		96	15.622	85.087	−30.497	1.00	16.10	O
ATOM	659	N	LYS		97	15.591	84.620	−28.303	1.00	14.87	N
ATOM	660	CA	LYS		97	16.177	85.904	−27.946	1.00	16.12	C
ATOM	661	CB	LYS		97	16.095	86.140	−26.438	1.00	16.60	C
ATOM	662	CG	LYS		97	14.713	86.525	−25.940	1.00	18.03	C
ATOM	663	CD	LYS		97	14.804	87.047	−24.522	1.00	19.06	C
ATOM	664	CE	LYS		97	13.481	87.604	−24.048	1.00	20.51	C
ATOM	665	NZ	LYS		97	13.591	88.152	−22.668	1.00	18.92	N
ATOM	666	C	LYS		97	17.620	86.051	−28.402	1.00	15.43	C
ATOM	667	O	LYS		97	18.071	87.165	−28.657	1.00	16.13	O
ATOM	668	N	SER		98	18.335	84.937	−28.508	1.00	16.35	N
ATOM	669	CA	SER		98	19.733	84.970	−28.945	1.00	18.06	C
ATOM	670	CB	SER		98	20.474	83.713	−28.472	1.00	18.53	C
ATOM	671	OG	SER		98	20.024	82.551	−29.154	1.00	18.00	O
ATOM	672	C	SER		98	19.832	85.070	−30.462	1.00	19.16	C
ATOM	673	O	SER		98	20.876	85.433	−31.012	1.00	19.15	O
ATOM	674	N	GLY		99	18.738	84.750	−31.144	1.00	18.86	N
ATOM	675	CA	GLY		99	18.757	84.802	−32.589	1.00	20.20	C
ATOM	676	C	GLY		99	19.252	83.490	−33.162	1.00	21.35	C
ATOM	677	O	GLY		99	19.389	83.353	−34.375	1.00	23.18	O
ATOM	678	N	GLU		100	19.530	82.521	−32.293	1.00	23.66	N
ATOM	679	CA	GLU		100	19.996	81.213	−32.742	1.00	26.39	C
ATOM	680	CB	GLU		100	20.320	80.321	−31.538	1.00	28.99	C
ATOM	681	CG	GLU		100	21.631	80.675	−30.845	1.00	37.69	C
ATOM	682	CD	GLU		100	21.837	79.928	−29.537	1.00	41.15	C
ATOM	683	OE1	GLU		100	21.211	80.305	−28.521	1.00	41.91	O
ATOM	684	OE2	GLU		100	22.625	78.957	−29.528	1.00	45.14	O
ATOM	685	C	GLU		100	18.913	80.562	−33.595	1.00	26.46	C
ATOM	686	O	GLU		100	19.192	79.974	−34.635	1.00	25.99	O
ATOM	687	N	GLU		101	17.670	80.693	−33.144	1.00	26.61	N
ATOM	688	CA	GLU		101	16.511	80.132	−33.829	1.00	29.10	C
ATOM	689	CB	GLU		101	16.009	78.900	−33.071	1.00	32.16	C
ATOM	690	CG	GLU		101	16.807	77.641	−33.322	1.00	37.54	C
ATOM	691	CD	GLU		101	16.420	76.982	−34.627	1.00	39.94	C
ATOM	692	OE1	GLU		101	16.469	77.660	−35.678	1.00	43.41	O
ATOM	693	OE2	GLU		101	16.059	75.788	−34.604	1.00	42.28	O
ATOM	694	C	GLU		101	15.411	81.182	−33.842	1.00	28.10	C
ATOM	695	O	GLU		101	15.305	81.965	−32.902	1.00	29.30	O
ATOM	696	N	ASP		102	14.602	81.232	−34.894	1.00	25.39	N
ATOM	697	CA	ASP		102	13.526	82.205	−34.865	1.00	26.40	C
ATOM	698	CB	ASP		102	13.366	82.937	−36.207	1.00	32.21	C
ATOM	699	CG	ASP		102	13.278	82.010	−37.387	1.00	36.42	C
ATOM	700	OD1	ASP		102	13.566	82.486	−38.513	1.00	37.45	O
ATOM	701	OD2	ASP		102	12.915	80.828	−37.201	1.00	39.49	O
ATOM	702	C	ASP		102	12.235	81.532	−34.413	1.00	24.14	C
ATOM	703	O	ASP		102	12.075	80.311	−34.517	1.00	22.07	O
ATOM	704	N	PHE		103	11.338	82.337	−33.865	1.00	21.65	N
ATOM	705	CA	PHE		103	10.069	81.849	−33.344	1.00	22.12	C
ATOM	706	CB	PHE		103	9.158	83.036	−33.019	1.00	22.80	C
ATOM	707	CG	PHE		103	7.826	82.635	−32.463	1.00	25.46	C
ATOM	708	CD1	PHE		103	7.652	82.464	−31.094	1.00	25.26	C
ATOM	709	CD2	PHE		103	6.758	82.363	−33.317	1.00	26.44	C
ATOM	710	CE1	PHE		103	6.433	82.023	−30.582	1.00	27.70	C
ATOM	711	CE2	PHE		103	5.537	81.920	−32.814	1.00	26.22	C
ATOM	712	CZ	PHE		103	5.376	81.750	−31.445	1.00	26.33	C
ATOM	713	C	PHE		103	9.324	80.891	−34.277	1.00	20.98	C
ATOM	714	O	PHE		103	8.910	79.804	−33.868	1.00	18.46	O
ATOM	715	N	GLU		104	9.154	81.310	−35.526	1.00	20.78	N
ATOM	716	CA	GLU		104	8.421	80.528	−36.517	1.00	22.06	C
ATOM	717	CB	GLU		104	8.401	81.277	−37.857	1.00	22.53	C
ATOM	718	CG	GLU		104	7.705	82.628	−37.781	1.00	22.38	C
ATOM	719	CD	GLU		104	8.637	83.761	−37.370	1.00	23.45	C
ATOM	720	OE1	GLU		104	9.647	83.505	−36.672	1.00	19.39	O
ATOM	721	OE2	GLU		104	8.344	84.916	−37.744	1.00	25.23	O
ATOM	722	C	GLU		104	8.957	79.120	−36.718	1.00	21.94	C
ATOM	723	O	GLU		104	8.186	78.163	−36.853	1.00	22.04	O
ATOM	724	N	SER		105	10.277	78.997	−36.742	1.00	20.26	N
ATOM	725	CA	SER		105	10.917	77.704	−36.932	1.00	21.32	C
ATOM	726	CB	SER		105	12.415	77.890	−37.141	1.00	21.99	C
ATOM	727	OG	SER		105	13.076	76.644	−37.147	1.00	26.14	O
ATOM	728	C	SER		105	10.670	76.765	−35.753	1.00	19.93	C
ATOM	729	O	SER		105	10.359	75.590	−35.950	1.00	19.78	O
ATOM	730	N	LEU		106	10.806	77.278	−34.533	1.00	18.63	N
ATOM	731	CA	LEU		106	10.588	76.458	−33.337	1.00	18.86	C
ATOM	732	CB	LEU		106	11.073	77.197	−32.086	1.00	16.64	C
ATOM	733	CG	LEU		106	12.577	77.498	−32.039	1.00	17.92	C
ATOM	734	CD1	LEU		106	12.919	78.223	−30.733	1.00	15.84	C
ATOM	735	CD2	LEU		106	13.360	76.196	−32.149	1.00	16.67	C
ATOM	736	C	LEU		106	9.119	76.069	−33.166	1.00	18.22	C
ATOM	737	O	LEU		106	8.807	74.962	−32.715	1.00	18.69	O
ATOM	738	N	ALA		107	8.217	76.982	−33.511	1.00	18.46	N
ATOM	739	CA	ALA		107	6.793	76.702	−33.405	1.00	18.77	C
ATOM	740	CB	ALA		107	5.974	77.956	−33.710	1.00	15.50	C
ATOM	741	C	ALA		107	6.427	75.588	−34.387	1.00	19.40	C
ATOM	742	O	ALA		107	5.729	74.636	−34.024	1.00	19.91	O
ATOM	743	N	SER		108	6.898	75.708	−35.628	1.00	18.82	N
ATOM	744	CA	SER		108	6.606	74.706	−36.652	1.00	19.26	C
ATOM	745	CB	SER		108	7.321	75.051	−37.963	1.00	18.70	C
ATOM	746	OG	SER		108	6.846	76.270	−38.504	1.00	25.22	O
ATOM	747	C	SER		108	7.070	73.331	−36.201	1.00	20.29	C
ATOM	748	O	SER		108	6.397	72.318	−36.414	1.00	19.94	O
ATOM	749	N	GLN		109	8.233	73.313	−35.569	1.00	20.19	N
ATOM	750	CA	GLN		109	8.840	72.083	−35.111	1.00	22.48	C
ATOM	751	CB	GLN		109	10.351	72.277	−35.004	1.00	23.64	C
ATOM	752	CG	GLN		109	11.091	72.370	−36.318	1.00	23.93	C
ATOM	753	CD	GLN		109	12.550	72.716	−36.108	1.00	26.60	C
ATOM	754	OE1	GLN		109	12.922	73.892	−36.027	1.00	28.06	O
ATOM	755	NE2	GLN		109	13.382	71.696	−35.993	1.00	22.73	N
ATOM	756	C	GLN		109	8.355	71.528	−33.787	1.00	21.26	C
ATOM	757	O	GLN		109	8.162	70.325	−33.652	1.00	23.73	O
ATOM	758	N	PHE		110	8.141	72.399	−32.811	1.00	21.48	N
ATOM	759	CA	PHE		110	7.799	71.919	−31.489	1.00	21.05	C
ATOM	760	CB	PHE		110	8.970	72.267	−30.558	1.00	19.79	C
ATOM	761	CG	PHE		110	10.314	71.871	−31.111	1.00	21.19	C
ATOM	762	CD1	PHE		110	11.269	72.834	−31.426	1.00	22.70	C
ATOM	763	CD2	PHE		110	10.618	70.532	−31.339	1.00	21.12	C
ATOM	764	CE1	PHE		110	12.506	72.469	−31.958	1.00	23.05	C
ATOM	765	CE2	PHE		110	11.850	70.156	−31.872	1.00	23.03	C
ATOM	766	CZ	PHE		110	12.798	71.125	−32.183	1.00	22.97	C
ATOM	767	C	PHE		110	6.485	72.286	−30.816	1.00	20.97	C
ATOM	768	O	PHE		110	6.225	71.818	−29.709	1.00	23.48	O
ATOM	769	N	SER		111	5.647	73.100	−31.442	1.00	19.06	N
ATOM	770	CA	SER		111	4.388	73.447	−30.797	1.00	19.77	C
ATOM	771	CB	SER		111	3.718	74.615	−31.506	1.00	18.27	C
ATOM	772	OG	SER		111	2.547	75.017	−30.810	1.00	21.31	O
ATOM	773	C	SER		111	3.438	72.245	−30.800	1.00	20.72	C
ATOM	774	O	SER		111	3.244	71.603	−31.834	1.00	20.55	O
ATOM	775	N	ASP		112	2.856	71.946	−29.640	1.00	21.42	N
ATOM	776	CA	ASP		112	1.925	70.820	−29.503	1.00	22.28	C
ATOM	777	CB	ASP		112	1.935	70.279	−28.066	1.00	21.16	C
ATOM	778	CG	ASP		112	3.157	69.433	−27.758	1.00	20.93	C
ATOM	779	OD1	ASP		112	3.440	68.479	−28.514	1.00	20.66	O
ATOM	780	OD2	ASP		112	3.831	69.708	−26.740	1.00	21.10	O
ATOM	781	C	ASP		112	0.506	71.256	−29.855	1.00	22.61	C
ATOM	782	O	ASP		112	−0.439	70.955	−29.127	1.00	23.97	O
ATOM	783	N	CYS		113	0.363	71.966	−30.970	1.00	23.07	N
ATOM	784	CA	CYS		113	−0.934	72.460	−31.420	1.00	23.29	C
ATOM	785	CB	CYS		113	−1.135	73.896	−30.913	1.00	23.08	C
ATOM	786	SG	CYS		113	−2.793	74.601	−31.067	1.00	28.34	S
ATOM	787	C	CYS		113	−0.903	72.420	−32.947	1.00	23.10	C
ATOM	788	O	CYS		113	0.153	72.614	−33.548	1.00	23.62	O
ATOM	789	N	SER		114	−2.043	72.161	−33.578	1.00	21.44	N
ATOM	790	CA	SER		114	−2.080	72.095	−35.038	1.00	22.98	C
ATOM	791	CB	SER		114	−3.482	71.701	−35.532	1.00	24.83	C
ATOM	792	OG	SER		114	−4.475	72.609	−35.085	1.00	30.07	O
ATOM	793	C	SER		114	−1.635	73.395	−35.716	1.00	21.59	C
ATOM	794	O	SER		114	−1.246	73.380	−36.887	1.00	20.64	O
ATOM	795	N	SER		115	−1.692	74.513	−34.991	1.00	20.09	N
ATOM	796	CA	SER		115	−1.267	75.798	−35.552	1.00	20.40	C
ATOM	797	CB	SER		115	−1.567	76.946	−34.578	1.00	20.34	C
ATOM	798	OG	SER		115	−1.058	76.686	−33.279	1.00	18.84	O
ATOM	799	C	SER		115	0.224	75.782	−35.897	1.00	19.24	C
ATOM	800	O	SER		115	0.732	76.691	−36.553	1.00	18.61	O
ATOM	801	N	ALA		116	0.927	74.749	−35.451	1.00	18.34	N
ATOM	802	CA	ALA		116	2.347	74.626	−35.751	1.00	17.43	C
ATOM	803	CB	ALA		116	2.902	73.333	−35.135	1.00	19.05	C
ATOM	804	C	ALA		116	2.546	74.609	−37.279	1.00	20.21	C
ATOM	805	O	ALA		116	3.560	75.097	−37.794	1.00	16.65	O
ATOM	806	N	LYS		117	1.573	74.044	−37.997	1.00	17.33	N
ATOM	807	CA	LYS		117	1.660	73.944	−39.454	1.00	18.42	C
ATOM	808	CB	LYS		117	0.540	73.050	−39.989	1.00	21.08	C
ATOM	809	CG	LYS		117	0.574	71.646	−39.421	1.00	23.48	C
ATOM	810	CD	LYS		117	1.818	70.906	−39.855	1.00	27.93	C
ATOM	811	CE	LYS		117	1.901	69.528	−39.196	1.00	30.51	C
ATOM	812	NZ	LYS		117	2.304	69.595	−37.766	1.00	28.97	N
ATOM	813	C	LYS		117	1.619	75.303	−40.141	1.00	17.85	C
ATOM	814	O	LYS		117	2.006	75.423	−41.304	1.00	15.46	O
ATOM	815	N	ALA		118	1.139	76.312	−39.417	1.00	16.31	N
ATOM	816	CA	ALA		118	1.085	77.682	−39.921	1.00	19.92	C
ATOM	817	CB	ALA		118	−0.332	78.255	−39.773	1.00	18.29	C
ATOM	818	C	ALA		118	2.086	78.532	−39.120	1.00	20.46	C
ATOM	819	O	ALA		118	1.835	79.708	−38.834	1.00	19.19	O
ATOM	820	N	ARG		119	3.208	77.920	−38.746	1.00	19.21	N
ATOM	821	CA	ARG		119	4.254	78.605	−37.989	1.00	21.33	C
ATOM	822	CB	ARG		119	4.891	79.712	−38.846	1.00	23.33	C
ATOM	823	CG	ARG		119	5.934	79.218	−39.842	1.00	26.77	C
ATOM	824	CD	ARG		119	6.122	80.180	−41.018	1.00	31.98	C
ATOM	825	NE	ARG		119	5.060	79.982	−42.002	1.00	39.55	N
ATOM	826	CZ	ARG		119	3.806	80.413	−41.867	1.00	40.57	C
ATOM	827	NH1	ARG		119	3.437	81.096	−40.790	1.00	42.45	N
ATOM	828	NH2	ARG		119	2.902	80.111	−42.790	1.00	36.83	N
ATOM	829	C	ARG		119	3.722	79.198	−36.688	1.00	20.81	C
ATOM	830	O	ARG		119	4.197	80.239	−36.230	1.00	19.48	O
ATOM	831	N	GLY		120	2.730	78.536	−36.103	1.00	18.20	N
ATOM	832	CA	GLY		120	2.163	79.009	−34.853	1.00	20.13	C
ATOM	833	C	GLY		120	1.083	80.065	−34.973	1.00	20.28	C
ATOM	834	O	GLY		120	0.455	80.412	−33.971	1.00	19.14	O
ATOM	835	N	ASP		121	0.850	80.570	−36.186	1.00	20.68	N
ATOM	836	CA	ASP		121	−0.164	81.607	−36.407	1.00	20.44	C
ATOM	837	CB	ASP		121	−0.150	82.082	−37.867	1.00	20.79	C
ATOM	838	CG	ASP		121	−1.209	83.152	−38.142	1.00	22.29	C
ATOM	839	OD1	ASP		121	−1.325	84.095	−37.333	1.00	22.47	O
ATOM	840	OD2	ASP		121	−1.919	83.062	−39.167	1.00	22.36	O
ATOM	841	C	ASP		121	−1.580	81.159	−36.050	1.00	21.23	C
ATOM	842	O	ASP		121	−2.026	80.088	−36.456	1.00	21.25	O
ATOM	843	N	LEU		122	−2.273	82.002	−35.294	1.00	21.72	N
ATOM	844	CA	LEU		122	−3.638	81.738	−34.860	1.00	22.17	C
ATOM	845	CB	LEU		122	−3.752	81.903	−33.343	1.00	21.46	C
ATOM	846	CG	LEU		122	−3.003	80.887	−32.480	1.00	21.02	C
ATOM	847	CD1	LEU		122	−3.119	81.286	−31.018	1.00	21.99	C
ATOM	848	CD2	LEU		122	−3.573	79.496	−32.712	1.00	21.00	C
ATOM	849	C	LEU		122	−4.623	82.683	−35.525	1.00	24.02	C
ATOM	850	O	LEU		122	−5.833	82.555	−35.342	1.00	24.81	O
ATOM	851	N	GLY		123	−4.109	83.633	−36.298	1.00	25.02	N
ATOM	852	CA	GLY		123	−4.986	84.591	−36.948	1.00	23.79	C
ATOM	853	C	GLY		123	−5.397	85.657	−35.950	1.00	25.45	C
ATOM	854	O	GLY		123	−4.952	85.638	−34.796	1.00	24.13	O
ATOM	855	N	ALA		124	−6.244	86.587	−36.382	1.00	24.35	N
ATOM	856	CA	ALA		124	−6.698	87.663	−35.510	1.00	24.82	C
ATOM	857	CB	ALA		124	−7.102	88.869	−36.339	1.00	25.39	C
ATOM	858	C	ALA		124	−7.867	87.224	−34.640	1.00	26.89	C
ATOM	859	O	ALA		124	−8.692	86.408	−35.054	1.00	28.64	O
ATOM	860	N	PHE		125	−7.935	87.773	−33.434	1.00	27.23	N
ATOM	861	CA	PHE		125	−9.007	87.451	−32.506	1.00	28.93	C
ATOM	862	CB	PHE		125	−8.651	86.187	−31.707	1.00	29.65	C
ATOM	863	CG	PHE		125	−7.347	86.280	−30.943	1.00	30.27	C
ATOM	864	CD1	PHE		125	−7.271	86.981	−29.743	1.00	30.55	C
ATOM	865	CD2	PHE		125	−6.204	85.640	−31.415	1.00	29.95	C
ATOM	866	CE1	PHE		125	−6.073	87.042	−29.019	1.00	30.06	C
ATOM	867	CE2	PHE		125	−5.002	85.693	−30.702	1.00	31.22	C
ATOM	868	CZ	PHE		125	−4.937	86.395	−29.500	1.00	28.65	C
ATOM	869	C	PHE		125	−9.286	88.623	−31.571	1.00	29.58	C
ATOM	870	O	PHE		125	−8.449	89.514	−31.406	1.00	30.38	O
ATOM	871	N	SER		126	−10.476	88.639	−30.984	1.00	30.78	N
ATOM	872	CA	SER		126	−10.844	89.702	−30.057	1.00	32.91	C
ATOM	873	CB	SER		126	−12.174	90.344	−30.475	1.00	34.77	C
ATOM	874	OG	SER		126	−13.223	89.393	−30.470	1.00	35.78	O
ATOM	875	C	SER		126	−10.965	89.082	−28.670	1.00	32.39	C
ATOM	876	O	SER		126	−10.806	87.869	−28.512	1.00	31.50	O
ATOM	877	N	ARG		127	−11.227	89.906	−27.661	1.00	33.69	N
ATOM	878	CA	ARG		127	−11.362	89.380	−26.311	1.00	34.29	C
ATOM	879	CB	ARG		127	−11.480	90.518	−25.295	1.00	33.79	C
ATOM	880	CG	ARG		127	−10.154	91.169	−24.925	1.00	33.56	C
ATOM	881	CD	ARG		127	−10.357	92.178	−23.810	1.00	30.80	C
ATOM	882	NE	ARG		127	−9.126	92.850	−23.398	1.00	31.57	N
ATOM	883	CZ	ARG		127	−8.138	92.282	−22.707	1.00	28.99	C
ATOM	884	NH1	ARG		127	−8.212	91.011	−22.339	1.00	27.53	N
ATOM	885	NH2	ARG		127	−7.078	93.003	−22.363	1.00	29.56	N
ATOM	886	C	ARG		127	−12.586	88.479	−26.224	1.00	35.91	C
ATOM	887	O	ARG		127	−13.568	88.674	−26.942	1.00	36.34	O
ATOM	888	N	GLY		128	−12.511	87.477	−25.358	1.00	36.68	N
ATOM	889	CA	GLY		128	−13.627	86.568	−25.190	1.00	37.74	C
ATOM	890	C	GLY		128	−13.636	85.374	−26.122	1.00	37.64	C
ATOM	891	O	GLY		128	−14.669	84.722	−26.265	1.00	39.65	O
ATOM	892	N	GLN		129	−12.504	85.079	−26.758	1.00	35.78	N
ATOM	893	CA	GLN		129	−12.426	83.940	−27.670	1.00	34.33	C
ATOM	894	CB	GLN		129	−12.048	84.393	−29.087	1.00	34.91	C
ATOM	895	CG	GLN		129	−12.884	85.531	−29.661	1.00	36.32	C
ATOM	896	CD	GLN		129	−12.544	85.818	−31.119	1.00	37.49	C
ATOM	897	OE1	GLN		129	−12.893	86.866	−31.656	1.00	39.45	O
ATOM	898	NE2	GLN		129	−11.867	84.878	−31.764	1.00	38.62	N
ATOM	899	C	GLN		129	−11.407	82.906	−27.202	1.00	33.56	C
ATOM	900	O	GLN		129	−11.659	81.705	−27.264	1.00	33.43	O
ATOM	901	N	MET		130	−10.253	83.378	−26.735	1.00	32.43	N
ATOM	902	CA	MET		130	−9.186	82.493	−26.274	1.00	30.95	C
ATOM	903	CB	MET		130	−7.829	83.068	−26.696	1.00	32.56	C
ATOM	904	CG	MET		130	−7.726	83.415	−28.176	1.00	32.35	C
ATOM	905	SD	MET		130	−7.822	81.957	−29.211	1.00	36.35	S
ATOM	906	CE	MET		130	−7.294	82.602	−30.794	1.00	35.60	C
ATOM	907	C	MET		130	−9.209	82.323	−24.754	1.00	30.40	C
ATOM	908	O	MET		130	−9.865	83.086	−24.048	1.00	30.69	O
ATOM	909	N	GLN		131	−8.496	81.319	−24.252	1.00	29.34	N
ATOM	910	CA	GLN		131	−8.433	81.108	−22.810	1.00	29.39	C
ATOM	911	CB	GLN		131	−7.512	79.931	−22.493	1.00	31.38	C
ATOM	912	CG	GLN		131	−7.961	78.652	−23.181	1.00	34.16	C
ATOM	913	CD	GLN		131	−7.066	77.471	−22.887	1.00	35.47	C
ATOM	914	OE1	GLN		131	−7.143	76.865	−21.820	1.00	37.92	O
ATOM	915	NE2	GLN		131	−6.202	77.137	−23.837	1.00	38.00	N
ATOM	916	C	GLN		131	−7.911	82.416	−22.208	1.00	29.40	C
ATOM	917	O	GLN		131	−7.004	83.050	−22.755	1.00	27.15	O
ATOM	918	N	LYS		132	−8.497	82.818	−21.087	1.00	27.37	N
ATOM	919	CA	LYS		132	−8.158	84.081	−20.439	1.00	27.29	C
ATOM	920	CB	LYS		132	−8.864	84.159	−19.078	1.00	25.74	C
ATOM	921	CG	LYS		132	−8.879	85.550	−18.472	1.00	27.26	C
ATOM	922	CD	LYS		132	−9.508	86.578	−19.406	1.00	25.54	C
ATOM	923	CE	LYS		132	−9.475	87.961	−18.774	1.00	27.97	C
ATOM	924	NZ	LYS		132	−9.815	89.046	−19.733	1.00	26.31	N
ATOM	925	C	LYS		132	−6.674	84.459	−20.286	1.00	25.45	C
ATOM	926	O	LYS		132	−6.270	85.546	−20.700	1.00	25.96	O
ATOM	927	N	PRO		133	−5.850	83.587	−19.687	1.00	25.30	N
ATOM	928	CD	PRO		133	−6.108	82.234	−19.164	1.00	25.57	C
ATOM	929	CA	PRO		133	−4.432	83.947	−19.536	1.00	26.02	C
ATOM	930	CB	PRO		133	−3.808	82.674	−18.962	1.00	25.81	C
ATOM	931	CG	PRO		133	−4.952	82.039	−18.213	1.00	28.23	C
ATOM	932	C	PRO		133	−3.793	84.345	−20.872	1.00	25.42	C
ATOM	933	O	PRO		133	−3.108	85.364	−20.973	1.00	24.40	O
ATOM	934	N	PHE		134	−4.030	83.523	−21.889	1.00	24.85	N
ATOM	935	CA	PHE		134	−3.498	83.754	−23.230	1.00	22.30	C
ATOM	936	CB	PHE		134	−3.967	82.630	−24.155	1.00	22.14	C
ATOM	937	CG	PHE		134	−3.269	82.598	−25.487	1.00	18.96	C
ATOM	938	CD1	PHE		134	−2.144	81.802	−25.679	1.00	19.71	C
ATOM	939	CD2	PHE		134	−3.738	83.360	−26.551	1.00	19.52	C
ATOM	940	CE1	PHE		134	−1.491	81.768	−26.923	1.00	20.20	C
ATOM	941	CE2	PHE		134	−3.092	83.332	−27.791	1.00	18.91	C
ATOM	942	CZ	PHE		134	−1.969	82.535	−27.973	1.00	18.42	C
ATOM	943	C	PHE		134	−4.005	85.099	−23.748	1.00	22.35	C
ATOM	944	O	PHE		134	−3.235	85.923	−24.256	1.00	21.63	O
ATOM	945	N	GLU		135	−5.312	85.317	−23.612	1.00	20.90	N
ATOM	946	CA	GLU		135	−5.944	86.552	−24.059	1.00	19.88	C
ATOM	947	CB	GLU		135	−7.442	86.543	−23.721	1.00	19.66	C
ATOM	948	CG	GLU		135	−8.115	87.888	−23.942	1.00	22.59	C
ATOM	949	CD	GLU		135	−9.577	87.887	−23.527	1.00	24.18	C
ATOM	950	OE1	GLU		135	−10.318	86.992	−23.980	1.00	23.97	O
ATOM	951	OE2	GLU		135	−9.975	88.783	−22.755	1.00	25.76	O
ATOM	952	C	GLU		135	−5.317	87.796	−23.447	1.00	19.84	C
ATOM	953	O	GLU		135	−4.905	88.716	−24.161	1.00	18.70	O
ATOM	954	N	ASP		136	−5.267	87.840	−22.120	1.00	18.82	N
ATOM	955	CA	ASP		136	−4.702	88.997	−21.440	1.00	20.21	C
ATOM	956	CB	ASP		136	−4.791	88.828	−19.919	1.00	22.82	C
ATOM	957	CG	ASP		136	−6.226	88.942	−19.403	1.00	26.00	C
ATOM	958	OD1	ASP		136	−7.021	89.701	−20.008	1.00	25.89	O
ATOM	959	OD2	ASP		136	−6.554	88.290	−18.389	1.00	26.58	O
ATOM	960	C	ASP		136	−3.262	89.253	−21.863	1.00	18.27	C
ATOM	961	O	ASP		136	−2.873	90.396	−22.109	1.00	17.82	O
ATOM	962	N	ALA		137	−2.477	88.186	−21.953	1.00	19.38	N
ATOM	963	CA	ALA		137	−1.085	88.313	−22.370	1.00	19.02	C
ATOM	964	CB	ALA		137	−0.398	86.948	−22.317	1.00	17.24	C
ATOM	965	C	ALA		137	−1.064	88.869	−23.797	1.00	17.73	C
ATOM	966	O	ALA		137	−0.363	89.830	−24.084	1.00	16.91	O
ATOM	967	N	SER		138	−1.862	88.278	−24.682	1.00	18.80	N
ATOM	968	CA	SER		138	−1.918	88.726	−26.075	1.00	19.09	C
ATOM	969	CB	SER		138	−2.959	87.924	−26.863	1.00	17.22	C
ATOM	970	OG	SER		138	−2.599	86.560	−26.929	1.00	16.63	O
ATOM	971	C	SER		138	−2.238	90.207	−26.207	1.00	20.37	C
ATOM	972	O	SER		138	−1.594	90.917	−26.977	1.00	18.45	O
ATOM	973	N	PHE		139	−3.232	90.677	−25.457	1.00	21.44	N
ATOM	974	CA	PHE		139	−3.621	92.078	−25.529	1.00	22.76	C
ATOM	975	CB	PHE		139	−5.071	92.261	−25.058	1.00	23.84	C
ATOM	976	CG	PHE		139	−6.084	91.897	−26.103	1.00	23.76	C
ATOM	977	CD1	PHE		139	−6.465	90.573	−26.293	1.00	24.31	C
ATOM	978	CD2	PHE		139	−6.593	92.871	−26.959	1.00	24.92	C
ATOM	979	CE1	PHE		139	−7.338	90.220	−27.330	1.00	25.59	C
ATOM	980	CE2	PHE		139	−7.462	92.530	−27.997	1.00	25.58	C
ATOM	981	CZ	PHE		139	−7.834	91.202	−28.182	1.00	23.61	C
ATOM	982	C	PHE		139	−2.710	93.044	−24.784	1.00	22.19	C
ATOM	983	O	PHE		139	−2.773	94.250	−25.014	1.00	23.46	O
ATOM	984	N	ALA		140	−1.866	92.521	−23.900	1.00	22.26	N
ATOM	985	CA	ALA		140	−0.944	93.365	−23.145	1.00	22.10	C
ATOM	986	CB	ALA		140	−0.659	92.749	−21.783	1.00	21.06	C
ATOM	987	C	ALA		140	0.355	93.545	−23.928	1.00	22.97	C
ATOM	988	O	ALA		140	1.113	94.485	−23.687	1.00	22.84	O
ATOM	989	N	LEU		141	0.605	92.635	−24.865	1.00	23.11	N
ATOM	990	CA	LEU		141	1.797	92.703	−25.702	1.00	24.24	C
ATOM	991	CB	LEU		141	1.997	91.396	−26.479	1.00	22.44	C
ATOM	992	CG	LEU		141	2.413	90.128	−25.740	1.00	22.58	C
ATOM	993	CD1	LEU		141	2.328	88.941	−26.694	1.00	20.79	C
ATOM	994	CD2	LEU		141	3.830	90.282	−25.201	1.00	22.42	C
ATOM	995	C	LEU		141	1.643	93.828	−26.710	1.00	26.34	C
ATOM	996	O	LEU		141	0.531	94.138	−27.147	1.00	27.56	O
ATOM	997	N	ARG		142	2.760	94.444	−27.072	1.00	27.25	N
ATOM	998	CA	ARG		142	2.751	95.503	−28.066	1.00	28.18	C
ATOM	999	CB	ARG		142	3.857	96.521	−27.757	1.00	32.17	C
ATOM	1000	CG	ARG		142	3.759	97.143	−26.350	1.00	35.93	C
ATOM	1001	CD	ARG		142	4.898	98.126	−26.081	1.00	41.00	C
ATOM	1002	NE	ARG		142	6.204	97.468	−26.056	1.00	44.51	N
ATOM	1003	CZ	ARG		142	6.755	96.929	−24.972	1.00	46.60	C
ATOM	1004	NH1	ARG		142	6.117	96.975	−23.810	1.00	47.17	N
ATOM	1005	NH2	ARG		142	7.936	96.327	−25.053	1.00	46.70	N
ATOM	1006	C	ARG		142	3.026	94.773	−29.382	1.00	27.39	C
ATOM	1007	O	ARG		142	3.561	93.662	−29.376	1.00	24.82	O
ATOM	1008	N	THR		143	2.651	95.366	−30.507	1.00	25.81	N
ATOM	1009	CA	THR		143	2.893	94.713	−31.785	1.00	25.66	C
ATOM	1010	CB	THR		143	2.419	95.585	−32.961	1.00	27.45	C
ATOM	1011	OG1	THR		143	0.989	95.629	−32.962	1.00	31.20	O
ATOM	1012	CG2	THR		143	2.898	95.013	−34.287	1.00	28.00	C
ATOM	1013	C	THR		143	4.377	94.400	−31.952	1.00	24.68	C
ATOM	1014	O	THR		143	5.232	95.267	−31.756	1.00	22.46	O
ATOM	1015	N	GLY		144	4.672	93.146	−32.288	1.00	21.98	N
ATOM	1016	CA	GLY		144	6.047	92.725	−32.483	1.00	22.85	C
ATOM	1017	C	GLY		144	6.702	92.132	−31.248	1.00	22.96	C
ATOM	1018	O	GLY		144	7.758	91.501	−31.342	1.00	23.14	O
ATOM	1019	N	GLU		145	6.070	92.320	−30.092	1.00	21.60	N
ATOM	1020	CA	GLU		145	6.600	91.824	−28.827	1.00	21.63	C
ATOM	1021	CB	GLU		145	6.106	92.714	−27.686	1.00	22.78	C
ATOM	1022	CG	GLU		145	6.417	92.190	−26.300	1.00	30.05	C
ATOM	1023	CD	GLU		145	6.070	93.191	−25.216	1.00	32.54	C
ATOM	1024	OE1	GLU		145	5.127	93.991	−25.432	1.00	33.01	O
ATOM	1025	OE2	GLU		145	6.732	93.170	−24.151	1.00	31.52	O
ATOM	1026	C	GLU		145	6.270	90.362	−28.532	1.00	21.30	C
ATOM	1027	O	GLU		145	5.258	89.820	−29.006	1.00	21.67	O
ATOM	1028	N	MET		146	7.137	89.727	−27.750	1.00	17.85	N
ATOM	1029	CA	MET		146	6.964	88.329	−27.383	1.00	18.52	C
ATOM	1030	CB	MET		146	8.170	87.508	−27.855	1.00	18.33	C
ATOM	1031	CG	MET		146	8.036	86.006	−27.647	1.00	18.45	C
ATOM	1032	SD	MET		146	9.473	85.107	−28.253	1.00	19.11	S
ATOM	1033	CE	MET		146	10.611	85.343	−26.885	1.00	17.93	C
ATOM	1034	C	MET		146	6.796	88.195	−25.871	1.00	17.61	C
ATOM	1035	O	MET		146	7.380	88.953	−25.091	1.00	15.74	O
ATOM	1036	N	SER		147	5.993	87.222	−25.463	1.00	15.54	N
ATOM	1037	CA	SER		147	5.736	86.993	−24.050	1.00	16.26	C
ATOM	1038	CB	SER		147	4.361	86.352	−23.868	1.00	15.11	C
ATOM	1039	OG	SER		147	4.441	84.965	−24.194	1.00	14.89	O
ATOM	1040	C	SER		147	6.757	86.041	−23.463	1.00	14.75	C
ATOM	1041	O	SER		147	7.610	85.510	−24.170	1.00	17.13	O
ATOM	1042	N	GLY		148	6.662	85.846	−22.152	1.00	15.66	N
ATOM	1043	CA	GLY		148	7.510	84.885	−21.475	1.00	16.34	C
ATOM	1044	C	GLY		148	6.613	83.656	−21.359	1.00	18.14	C
ATOM	1045	O	GLY		148	5.650	83.536	−22.119	1.00	18.35	O
ATOM	1046	N	PRO		149	6.883	82.725	−20.437	1.00	19.97	N
ATOM	1047	CD	PRO		149	8.083	82.538	−19.604	1.00	19.15	C
ATOM	1048	CA	PRO		149	5.994	81.560	−20.354	1.00	19.60	C
ATOM	1049	CB	PRO		149	6.705	80.648	−19.357	1.00	19.40	C
ATOM	1050	CG	PRO		149	8.155	81.036	−19.499	1.00	19.39	C
ATOM	1051	C	PRO		149	4.606	81.976	−19.858	1.00	20.03	C
ATOM	1052	O	PRO		149	4.490	82.648	−18.835	1.00	19.61	O
ATOM	1053	N	VAL		150	3.564	81.591	−20.592	1.00	18.37	N
ATOM	1054	CA	VAL		150	2.185	81.911	−20.204	1.00	17.89	C
ATOM	1055	CB	VAL		150	1.476	82.752	−21.289	1.00	16.88	C
ATOM	1056	CG1	VAL		150	−0.003	82.912	−20.953	1.00	17.72	C
ATOM	1057	CG2	VAL		150	2.139	84.123	−21.392	1.00	18.15	C
ATOM	1058	C	VAL		150	1.441	80.585	−19.994	1.00	18.54	C
ATOM	1059	O	VAL		150	1.385	79.745	−20.893	1.00	20.63	O
ATOM	1060	N	PHE		151	0.880	80.403	−18.802	1.00	18.16	N
ATOM	1061	CA	PHE		151	0.187	79.166	−18.466	1.00	19.83	C
ATOM	1062	CB	PHE		151	0.457	78.802	−17.001	1.00	18.89	C
ATOM	1063	CG	PHE		151	1.919	78.736	−16.645	1.00	19.97	C
ATOM	1064	CD1	PHE		151	2.670	79.901	−16.516	1.00	21.49	C
ATOM	1065	CD2	PHE		151	2.543	77.510	−16.448	1.00	20.07	C
ATOM	1066	CE1	PHE		151	4.030	79.846	−16.193	1.00	21.89	C
ATOM	1067	CE2	PHE		151	3.907	77.441	−16.123	1.00	20.62	C
ATOM	1068	CZ	PEE		151	4.647	78.610	−15.996	1.00	21.08	C
ATOM	1069	C	PHE		151	−1.324	79.198	−18.689	1.00	20.80	C
ATOM	1070	O	PHE		151	−1.990	80.183	−18.379	1.00	22.68	O
ATOM	1071	N	THR		152	−1.849	78.111	−19.243	1.00	22.86	N
ATOM	1072	CA	THR		152	−3.285	77.957	−19.480	1.00	22.63	C
ATOM	1073	CB	THR		152	−3.693	78.253	−20.941	1.00	22.02	C
ATOM	1074	OG1	THR		152	−3.093	77.272	−21.798	1.00	20.71	O
ATOM	1075	CG2	THR		152	−3.271	79.643	−21.358	1.00	20.29	C
ATOM	1076	C	THR		152	−3.543	76.477	−19.251	1.00	21.73	C
ATOM	1077	O	THR		152	−2.602	75.705	−19.048	1.00	21.87	O
ATOM	1078	N	ASP		153	−4.805	76.068	−19.307	1.00	24.33	N
ATOM	1079	CA	ASP		153	−5.123	74.658	−19.126	1.00	25.99	C
ATOM	1080	CB	ASP		153	−6.631	74.477	−18.965	1.00	30.01	C
ATOM	1081	CG	ASP		153	−7.112	74.928	−17.610	1.00	35.09	C
ATOM	1082	OD1	ASP		153	−6.560	74.422	−16.612	1.00	37.74	O
ATOM	1083	OD2	ASP		153	−8.023	75.781	−17.535	1.00	39.10	O
ATOM	1084	C	ASP		153	−4.606	73.796	−20.271	1.00	25.66	C
ATOM	1085	O	ASP		153	−4.556	72.572	−20.162	1.00	25.55	O
ATOM	1086	N	SER		154	−4.223	74.434	−21.375	1.00	24.11	N
ATOM	1087	CA	SER		154	−3.696	73.701	−22.519	1.00	22.95	C
ATOM	1088	CB	SER		154	−3.823	74.527	−23.803	1.00	23.27	C
ATOM	1089	OG	SER		154	−5.179	74.756	−24.119	1.00	27.06	O
ATOM	1090	C	SER		154	−2.229	73.353	−22.302	1.00	21.74	C
ATOM	1091	O	SER		154	−1.741	72.348	−22.810	1.00	21.26	O
ATOM	1092	N	GLY		155	−1.534	74.190	−21.541	1.00	21.35	N
ATOM	1093	CA	GLY		155	−0.124	73.957	−21.285	1.00	20.66	C
ATOM	1094	C	GLY		155	0.600	75.278	−21.088	1.00	20.14	C
ATOM	1095	O	GLY		155	0.043	76.211	−20.505	1.00	21.33	O
ATOM	1096	N	ILE		156	1.838	75.360	−21.566	1.00	19.48	N
ATOM	1097	CA	ILE		156	2.624	76.585	−21.434	1.00	17.83	C
ATOM	1098	CB	ILE		156	3.964	76.314	−20.731	1.00	19.45	C
ATOM	1099	CG2	ILE		156	4.685	77.638	−20.452	1.00	20.57	C
ATOM	1100	CG1	ILE		156	3.717	75.565	−19.418	1.00	21.12	C
ATOM	1101	CD1	ILE		156	4.996	75.084	−18.742	1.00	21.13	C
ATOM	1102	C	ILE		156	2.903	77.153	−22.823	1.00	17.34	C
ATOM	1103	O	ILE		156	3.376	76.442	−23.712	1.00	15.78	O
ATOM	1104	N	HIS		157	2.623	78.442	−22.995	1.00	17.88	N
ATOM	1105	CA	HIS		157	2.812	79.104	−24.285	1.00	17.22	C
ATOM	1106	CB	HIS		157	1.532	79.813	−24.735	1.00	17.03	C
ATOM	1107	CG	HIS		157	0.270	79.032	−24.545	1.00	21.13	C
ATOM	1108	CD2	HIS		157	−0.401	78.673	−23.422	1.00	21.81	C
ATOM	1109	ND1	HIS		157	−0.518	78.635	−25.605	1.00	19.22	N
ATOM	1110	CE1	HIS		157	−1.622	78.073	−25.145	1.00	22.18	C
ATOM	1111	NE2	HIS		157	−1.577	78.084	−23.824	1.00	21.37	N
ATOM	1112	C	HIS		157	3.878	80.199	−24.317	1.00	17.58	C
ATOM	1113	O	HIS		157	4.198	80.816	−23.297	1.00	16.44	O
ATOM	1114	N	ILE		158	4.389	80.431	−25.522	1.00	16.72	N
ATOM	1115	CA	ILE		158	5.302	81.521	−25.815	1.00	17.11	C
ATOM	1116	CB	ILE		158	6.594	81.076	−26.512	1.00	18.65	C
ATOM	1117	CG2	ILE		158	7.356	82.314	−26.995	1.00	18.68	C
ATOM	1118	CG1	ILE		158	7.470	80.275	−25.549	1.00	19.23	C
ATOM	1119	CD1	ILE		158	8.655	79.600	−26.228	1.00	19.68	C
ATOM	1120	C	ILE		158	4.412	82.218	−26.841	1.00	17.26	C
ATOM	1121	O	ILE		158	3.994	81.594	−27.823	1.00	18.55	O
ATOM	1122	N	ILE		159	4.092	83.486	−26.610	1.00	16.20	N
ATOM	1123	CA	ILE		159	3.206	84.213	−27.515	1.00	16.72	C
ATOM	1124	CB	ILE		159	1.991	84.782	−26.750	1.00	15.63	C
ATOM	1125	CG2	ILE		159	1.007	85.438	−27.725	1.00	15.56	C
ATOM	1126	CG1	ILE		159	1.324	83.659	−25.950	1.00	18.35	C
ATOM	1127	CD1	ILE		159	0.233	84.131	−25.010	1.00	13.68	C
ATOM	1128	C	ILE		159	3.882	85.369	−28.236	1.00	17.33	C
ATOM	1129	O	ILE		159	4.592	86.161	−27.623	1.00	17.96	O
ATOM	1130	N	LEU		160	3.640	85.462	−29.540	1.00	16.08	N
ATOM	1131	CA	LEU		160	4.204	86.542	−30.348	1.00	17.81	C
ATOM	1132	CB	LEU		160	5.076	85.974	−31.473	1.00	15.82	C
ATOM	1133	CG	LEU		160	5.670	87.024	−32.419	1.00	16.76	C
ATOM	1134	CD1	LEU		160	6.699	87.847	−31.668	1.00	15.36	C
ATOM	1135	CD2	LEU		160	6.322	86.354	−33.619	1.00	17.05	C
ATOM	1136	C	LEU		160	3.071	87.345	−30.967	1.00	16.24	C
ATOM	1137	O	LEU		160	2.278	86.805	−31.728	1.00	16.17	O
ATOM	1138	N	ARG		161	2.969	88.626	−30.637	1.00	18.92	N
ATOM	1139	CA	ARG		161	1.911	89.426	−31.234	1.00	20.23	C
ATOM	1140	CB	ARG		161	1.482	90.575	−30.322	1.00	20.66	C
ATOM	1141	CG	ARG		161	0.3.73	91.405	−30.955	1.00	21.45	C
ATOM	1142	CD	ARG		161	−0.061	92.588	−30.106	1.00	22.90	C
ATOM	1143	NE	ARG		161	−0.886	93.485	−30.913	1.00	24.24	N
ATOM	1144	CZ	ARG		161	−1.254	94.706	−30.543	1.00	27.93	C
ATOM	1145	NH1	ARG		161	−0.873	95.185	−29.363	1.00	27.83	N
ATOM	1146	NH2	ARG		161	−1.983	95.457	−31.364	1.00	25.63	N
ATOM	1147	C	ARG		161	2.445	89.969	−32.551	1.00	19.80	C
ATOM	1148	O	ARG		161	3.473	90.645	−32.584	1.00	20.36	O
ATOM	1149	N	THR		162	1.744	89.663	−33.634	1.00	20.07	N
ATOM	1150	CA	THR		162	2.165	90.086	−34.961	1.00	21.67	C
ATOM	1151	CB	THR		162	2.086	88.907	−35.931	1.00	21.24	C
ATOM	1152	OG1	THR		162	0.756	88.373	−35.919	1.00	21.27	O
ATOM	1153	CG2	THR		162	3.065	87.815	−35.512	1.00	17.97	C
ATOM	1154	C	THR		162	1.354	91.249	−35.529	1.00	23.61	C
ATOM	1155	O	THR		162	1.780	91.890	−36.488	1.00	23.31	O
ATOM	1156	N	GLU		163	0.191	91.514	−34.938	1.00	24.13	N
ATOM	1157	CA	GLU		163	−0.679	92.598	−35.389	1.00	25.11	C
ATOM	1158	CB	GLU		163	−1.600	92.106	−36.514	1.00	26.50	C
ATOM	1159	CG	GLU		163	−0.922	91.890	−37.856	1.00	27.37	C
ATOM	1160	CD	GLU		163	−1.885	91.359	−38.911	1.00	30.99	C
ATOM	1161	OE1	GLU		163	−3.095	91.655	−38.818	1.00	31.76	O
ATOM	1162	OE2	GLU		163	−1.431	90.655	−39.839	1.00	32.55	O
ATOM	1163	C	GLU		163	−1.538	93.128	−34.248	1.00	24.59	C
ATOM	1164	O	GLU		163	−1.771	92.371	−33.285	1.00	23.98	O
ATOM	1165	OXT	GLU		163	−1.995	94.285	−34.344	1.00	23.92	O
ATOM	1166	OH2	TIP	S	1	4.996	92.293	−22.205	1.00	22.33	O
ATOM	1167	OH2	TIP	S	2	3.904	94.668	−23.331	1.00	19.09	O
ATOM	1168	OH2	TIP	S	3	16.835	89.300	−27.847	1.00	18.64	O
ATOM	1169	OH2	TIP	S	4	4.478	71.586	−38.273	1.00	17.60	O
ATOM	1170	OH2	TIP	S	5	1.493	76.589	−32.561	1.00	18.71	O
ATOM	1171	OH2	TIP	S	6	2.829	86.799	−13.992	1.00	22.50	O
ATOM	1172	OH2	TIP	S	7	14.735	85.536	−32.999	1.00	17.41	O
ATOM	1173	OH2	TIP	S	8	1.586	86.170	−38.741	1.00	26.18	O
ATOM	1174	OH2	TIP	S	9	14.294	73.884	−25.020	1.00	23.10	O
ATOM	1175	OH2	TIP	S	10	4.098	82.829	−36.928	1.00	21.12	O
ATOM	1176	OH2	TIP	S	11	−9.802	85.994	−26.475	1.00	29.89	O
ATOM	1177	OH2	TIP	S	12	5.050	76.024	−40.565	1.00	22.93	O
ATOM	1178	OH2	TIP	S	13	14.963	90.911	−23.596	1.00	25.00	O
ATOM	1179	OH2	TIP	S	14	5.367	66.693	−27.487	1.00	24.18	O
ATOM	1180	OH2	TIP	S	15	6.032	63.967	−23.108	1.00	29.08	O
ATOM	1181	OH2	TIP	S	16	2.596	76.938	−43.445	1.00	20.23	O
ATOM	1182	OH2	TIP	S	17	18.067	98.333	−17.353	1.00	24.92	O
ATOM	1183	OH2	TIP	S	18	9.702	89.713	−30.296	1.00	26.29	O
ATOM	1184	OH2	TIP	S	19	−12.052	88.072	−20.923	1.00	29.06	O
ATOM	1185	OH2	TIP	S	20	12.519	69.724	−20.067	1.00	29.52	O
ATOM	1186	OH2	TIP	S	21	5.362	77.311	−42.993	1.00	27.16	O
ATOM	1187	OH2	TIP	S	22	16.494	93.043	−23.048	1.00	26.53	O
ATOM	1188	OH2	TIP	S	23	14.077	81.918	−21.032	1.00	23.49	O
ATOM	1189	OH2	TIP	S	24	6.543	82.880	−16.782	1.00	26.43	O
ATOM	1190	OH2	TIP	S	25	10.451	86.570	−17.616	1.00	27.70	O
ATOM	1191	OH2	TIP	S	26	3.027	59.344	−30.431	1.00	33.40	O
ATOM	1192	OH2	TIP	S	27	13.001	70.485	−28.343	1.00	29.47	O
ATOM	1193	OH2	TIP	S	28	−4.495	92.277	−21.189	1.00	31.94	O
ATOM	1194	OH2	TIP	S	29	−4.163	71.408	−32.025	1.00	27.78	O
ATOM	1195	OH2	TIP	S	30	−2.003	81.843	−41.579	1.00	35.12	O
ATOM	1196	OH2	TIP	S	31	−11.542	92.565	−28.064	1.00	33.33	O
ATOM	1197	OH2	TIP	S	32	−2.782	69.641	−29.548	1.00	30.94	O
ATOM	1198	OH2	TIP	S	33	0.077	74.916	−17.705	1.00	27.54	O
ATOM	1199	OH2	TIP	S	34	−1.798	86.275	−18.776	1.00	22.76	O
ATOM	1200	OH2	TIP	S	35	11.527	82.271	−19.663	1.00	29.95	O
ATOM	1201	OH2	TIP	S	36	12.435	69.156	−35.685	1.00	36.02	O
ATOM	1202	OH2	TIP	S	37	6.525	70.164	−27.535	1.00	26.81	O
ATOM	1203	OH2	TIP	S	38	15.072	88.089	−18.216	1.00	25.26	O
ATOM	1204	OH2	TIP	S	39	8.927	70.472	−26.831	1.00	26.75	O
ATOM	1205	OH2	TIP	S	40	−4.554	56.096	−32.538	1.00	46.41	O
ATOM	1206	OH2	TIP	S	41	−6.592	78.691	−19.130	1.00	34.05	O
ATOM	1207	OH2	TIP	S	42	10.941	90.094	−11.523	1.00	31.06	O
ATOM	1208	OH2	TIP	S	43	27.416	94.285	−11.592	1.00	39.24	O
ATOM	1209	OH2	TIP	S	44	17.021	88.279	−11.350	1.00	39.39	O
ATOM	1210	OH2	TIP	S	45	−11.320	84.727	−22.664	1.00	37.94	O
ATOM	1211	OH2	TIP	S	46	8.130	90.624	−34.026	1.00	29.86	O
ATOM	1212	OH2	TIP	S	47	−1.729	68.721	−32.242	1.00	29.50	O
ATOM	1213	OH2	TIP	S	48	−4.411	94.820	−34.154	1.00	31.74	O
ATOM	1214	OH2	TIP	S	49	16.939	96.485	−24.679	1.00	37.27	O
ATOM	1215	OH2	TIP	S	50	0.991	96.551	−21.899	1.00	33.01	O
ATOM	1216	OH2	TIP	S	51	2.693	58.746	−27.460	1.00	40.54	O
ATOM	1217	OH2	TIP	S	52	11.179	73.774	−14.605	1.00	35.96	O
ATOM	1218	OH2	TIP	S	53	20.243	79.681	−26.059	1.00	44.12	O
ATOM	1219	OH2	TIP	S	54	−1.551	88.145	−14.461	1.00	41.34	O
ATOM	1220	OH2	TIP	S	55	10.812	79.660	−40.306	1.00	41.96	O
ATOM	1221	OH2	TIP	S	56	9.581	91.050	−27.357	1.00	36.77	O
ATOM	1222	OH2	TIP	S	57	0.588	85.609	−36.254	1.00	20.89	O
ATOM	1223	OH2	TIP	S	58	1.467	56.895	−31.356	1.00	36.77	O
ATOM	1224	OH2	TIP	S	59	−7.051	71.283	−35.374	1.00	44.19	O
ATOM	1225	OH2	TIP	S	60	10.725	87.273	−30.581	1.00	20.71	O
ATOM	1226	OH2	TIP	S	61	23.232	91.784	−19.476	1.00	26.11	O
ATOM	1227	OH2	TIP	S	62	−4.934	58.687	−29.339	1.00	35.95	O
ATOM	1228	OH2	TIP	S	63	9.871	87.603	−12.492	1.00	30.66	O
ATOM	1229	OH2	TIP	S	64	−13.005	84.066	−20.570	1.00	31.49	O
ATOM	1230	OH2	TIP	S	65	8.069	66.785	−33.871	1.00	37.90	O
ATOM	1231	OH2	TIP	S	66	7.786	80.984	−15.179	1.00	32.21	O
ATOM	1232	OH2	TIP	S	67	−3.967	87.413	−16.543	1.00	35.89	O
ATOM	1233	OH2	TIP	S	68	15.843	75.405	−20.027	1.00	32.99	O
ATOM	1234	OH2	TIP	S	69	18.704	92.052	−24.094	1.00	40.34	O
ATOM	1235	OH2	TIP	S	70	14.924	71.626	−26.622	1.00	39.48	O
ATOM	1236	OH2	TIP	S	71	−7.578	73.953	−21.960	1.00	36.90	O
ATOM	1237	OH2	TIP	S	72	4.357	63.739	−35.563	1.00	36.35	O
ATOM	1238	OH2	TIP	S	73	−0.680	96.464	−26.110	1.00	40.17	O
ATOM	1239	OH2	TIP	S	74	14.838	89.361	−10.347	1.00	47.16	O
ATOM	1240	OH2	TIP	S	75	4.185	93.296	−8.477	1.00	46.61	O
ATOM	1241	OH2	TIP	S	76	9.639	67.060	−13.355	1.00	42.21	O
ATOM	1242	OH2	TIP	S	77	−8.619	91.119	−17.955	1.00	45.22	O
ATOM	1243	OH2	TIP	S	78	11.431	67.104	−21.172	1.00	43.05	O
ATOM	1244	OH2	TIP	S	79	−10.529	81.014	−19.998	1.00	40.81	O
ATOM	1245	OH2	TIP	S	80	18.262	74.953	−25.341	1.00	45.73	O
ATOM	1246	OH2	TIP	S	81	−8.270	83.821	−35.626	1.00	42.43	O
ATOM	1247	OH2	TIP	S	82	−5.257	92.334	−36.516	1.00	44.54	O
ATOM	1248	OH2	TIP	S	83	24.875	97.135	−9.923	1.00	48.63	O
ATOM	1249	OH2	TIP	S	84	−10.775	82.437	−32.093	1.00	53.25	O
ATOM	1250	OH2	TIP	S	85	2.471	67.905	−14.830	1.00	37.86	O
ATOM	1251	OH2	TIP	S	86	15.900	102.036	−16.997	1.00	45.47	O
ATOM	1252	OH2	TIP	S	87	18.249	83.052	−19.151	1.00	40.32	O
ATOM	1253	OH2	TIP	S	88	21.041	79.609	−19.141	1.00	45.55	O
ATOM	1254	OH2	TIP	S	89	2.124	58.830	−33.333	1.00	44.53	O
ATOM	1255	OH2	TIP	S	90	10.828	83.746	−17.756	1.00	44.80	O
ATOM	1256	OH2	TIP	S	91	15.547	73.007	−22.889	1.00	43.13	O
ATOM	1257	OH2	TIP	S	92	15.824	81.889	−19.101	1.00	33.52	O
ATOM	1258	OH2	TIP	S	93	−4.678	89.942	−39.858	1.00	47.08	O
ATOM	1259	OH2	TIP	S	94	12.133	89.060	−27.026	1.00	40.68	O
ATOM	1260	OH2	TIP	S	95	13.939	80.272	−39.801	1.00	42.43	O
ATOM	1261	OH2	TIP	S	96	13.282	91.087	−25.735	1.00	54.38	O
ATOM	1262	OH2	TIP	S	97	9.728	93.063	−8.513	1.00	46.78	O
ATOM	1263	OH2	TIP	S	98	10.268	67.985	−26.895	1.00	49.19	O
ATOM	1264	OH2	TIP	S	99	5.654	84.634	−38.615	1.00	47.56	O
ATOM	1265	OH2	TIP	S	100	−8.209	77.763	−27.166	1.00	41.45	O
ATOM	1266	OH2	TIP	S	101	15.842	72.276	−34.464	1.00	45.45	O
ATOM	1267	OH2	TIP	S	102	0.992	98.097	−30.418	1.00	47.28	O
ATOM	1268	OH2	TIP	S	103	14.928	70.921	−21.453	1.00	46.03	O
ATOM	1269	OH2	TIP	S	104	21.961	80.057	−36.566	1.00	54.72	O
ATOM	1270	OH2	TIP	S	105	−9.589	77.974	−19.455	1.00	39.81	O
ATOM	1271	OH2	TIP	S	106	20.556	88.719	−14.791	1.00	37.91	O
ATOM	1272	OH2	TIP	S	107	−3.922	71.217	−13.348	1.00	36.43	O
ATOM	1273	OH2	TIP	S	108	2.761	99.624	−15.558	1.00	49.03	O
ATOM	1274	OH2	TIP	S	109	20.532	99.746	−13.057	1.00	40.66	O
ATOM	1275	OH2	TIP	S	110	2.200	88.512	−39.451	1.00	42.35	O
ATOM	1276	OH2	TIP	S	111	−0.243	98.079	−33.871	1.00	45.52	O
ATOM	1277	OH2	TIP	S	112	2.345	94.561	−37.605	1.00	47.43	O
ATOM	1278	OH2	TIP	S	113	9.704	74.745	−12.514	1.00	48.37	O
ATOM	1279	O1	PGA	B	180	16.285	89.067	−15.776	1.00	34.19	O
ATOM	1280	C2	PGA	B	180	17.040	90.193	−15.926	1.00	30.20	C
ATOM	1281	C3	PGA	B	180	16.661	90.929	−17.214	1.00	29.59	C
ATOM	1282	O4	PGA	B	180	17.026	90.220	−18.272	1.00	29.69	O
ATOM	1283	C5	PGA	B	180	16.716	90.812	−19.431	1.00	26.84	C
ATOM	1284	C6	PGA	B	180	17.182	89.912	−20.595	1.00	28.92	C
ATOM	1285	O7	PGA	B	180	16.724	88.650	−20.399	1.00	27.81	O
ATOM	1286	C8	PGA	B	180	17.086	87.798	−21.370	1.00	25.04	C
ATOM	1287	C9	PGA	B	180	16.507	86.410	−21.040	1.00	25.59	C
ATOM	1288	O10	PGA	B	180	15.136	86.455	−21.050	1.00	25.09	O
ATOM	1289	C11	PGA	B	180	14.598	85.259	−20.760	1.00	24.29	C
ATOM	1290	C12	PGA	B	180	13.117	85.435	−20.368	1.00	25.67	C
ATOM	1291	O13	PGA	B	180	12.444	86.021	−21.365	1.00	23.85	O
ATOM	1292	C14	PGA	B	180	11.161	86.166	−21.029	1.00	29.38	C
ATOM	1293	C15	PGA	B	180	10.391	86.849	−22.179	1.00	30.98	C
ATOM	1294	O16	PGA	B	180	10.795	88.116	−22.353	1.00	31.74	O
ATOM	1295	C17	PGA	B	180	10.277	88.508	−23.469	1.00	37.46	C
ATOM	1296	C18	PGA	B	180	10.644	89.938	−23.815	1.00	40.16	C
ATOM	1297	O19	PGA	B	180	10.068	90.217	−24.949	1.00	44.29	O
ATOM	1298	O1	PGB	C	181	−6.751	79.793	−25.879	1.00	38.35	O
ATOM	1299	C2	PGB	C	181	−5.559	80.213	−26.288	1.00	40.88	C
ATOM	1300	C3	PGB	C	181	−5.052	79.372	−27.484	1.00	40.71	C
ATOM	1301	O4	PGB	C	181	−5.160	78.075	−27.211	1.00	44.58	O
ATOM	1302	C5	PGB	C	181	−4.724	77.341	−28.259	1.00	45.07	C
ATOM	1303	C6	PGB	C	181	−4.847	75.836	−27.942	1.00	47.07	C
ATOM	1304	O7	PGB	C	181	−3.638	75.359	−27.580	1.00	46.85	O
ATOM	1305	O8	C21		21	−10.942	69.468	−28.934	1.00	64.01	O
ATOM	1306	C7	C21		21	−10.997	69.859	−27.769	1.00	64.20	C
ATOM	1307	C9	C21		21	−9.695	70.185	−27.002	1.00	62.13	C
ATOM	1308	C10	C21		21	−9.789	70.641	−25.634	1.00	62.02	C
ATOM	1309	C11	C21		21	−11.161	70.801	−24.958	1.00	63.36	C
ATOM	1310	C4	C21		21	−12.451	70.474	−25.729	1.00	64.92	C
ATOM	1311	C5	C21		21	−13.735	70.618	−25.107	1.00	65.55	C
ATOM	1312	C6	C21		21	−14.926	70.313	−25.829	1.00	66.30	C
ATOM	1313	C1	C21		21	−14.847	69.861	−27.179	1.00	66.65	C
ATOM	1314	C2	C21		21	−13.577	69.714	−27.808	1.00	66.21	C
ATOM	1315	C3	C21		21	−12.370	70.016	−27.094	1.00	65.16	C
ATOM	1316	O12	C21		21	−11.228	71.190	−23.796	1.00	63.77	O
ATOM	1317	C13	C21		21	−8.598	70.947	−24.906	1.00	59.33	C
ATOM	1318	C14	C21		21	−7.313	70.807	−25.508	1.00	56.59	C
ATOM	1319	S10	C21		21	−5.832	71.191	−24.585	1.00	52.91	S
ATOM	1320	O20	C21		21	−5.051	69.986	−24.421	1.00	51.47	O
ATOM	1321	O21	C21		21	−6.252	71.876	−23.366	1.00	52.93	O
ATOM	1322	O22	C21		21	−5.143	72.153	−25.516	1.00	52.55	O
ATOM	1323	C15	C21		21	−7.212	70.356	−26.860	1.00	58.26	C
ATOM	1324	O18	C21		21	−5.949	70.220	−27.450	1.00	55.87	O
ATOM	1325	C16	C21		21	−8.391	70.045	−27.607	1.00	60.54	C
ATOM	1326	O17	C21		21	−8.226	69.607	−28.931	1.00	60.45	O

[0194] Pin1 R14A/Pin-420 Interactions

[0195] The crystal structure of the co-complex with PIN-420 (the coordinate set is set forth in Table 3), shows interaction with Met130, Gln131, Ser154, and Cys113. PIN-420 alters the local protein environment by disrupting the hydrogen bond between Gln131 and Ser154. The normal hydrogen bond contact between Gln131 and Ser154 is disrupted, and each residue now interacts with PIN-420.

TABLE 3
Set of atomic coordinates of Pin1 R14A with PIN-420 bound in the active site.
ATOM	1	CB	LEU		7	56.132	105.496	−69.819	1.00	45.12	A	C
ATOM	2	CG	LEU		7	57.034	104.380	−69.260	1.00	46.13	A	C
ATOM	3	CD1	LEU		7	56.338	103.659	−68.119	1.00	45.79	A	C
ATOM	4	CD2	LEU		7	57.393	103.419	−70.380	1.00	46.32	A	C
ATOM	5	C	LEU		7	55.509	107.385	−71.286	1.00	43.21	A	C
ATOM	6	O	LEU		7	54.972	108.259	−70.628	1.00	42.24	A	O
ATOM	7	N	LEU		7	57.559	107.542	−69.911	1.00	44.95	A	N
ATOM	8	CA	LEU		7	56.688	106.614	−70.713	1.00	44.20	A	C
ATOM	9	N	PRO		8	55.070	107.039	−72.507	1.00	42.79	A	N
ATOM	10	CD	PRO		8	55.541	105.904	−73.315	1.00	43.31	A	C
ATOM	11	CA	PRO		8	53.936	107.710	−73.157	1.00	42.15	A	C
ATOM	12	CB	PRO		8	53.768	106.942	−74.473	1.00	42.75	A	C
ATOM	13	CG	PRO		8	55.102	106.306	−74.706	1.00	43.37	A	C
ATOM	14	C	PRO		8	52.652	107.664	−72.298	1.00	41.60	A	C
ATOM	15	O	PRO		8	52.526	106.865	−71.349	1.00	42.16	A	O
ATOM	16	N	PRO		9	51.672	108.517	−72.635	1.00	40.32	A	N
ATOM	17	CD	PRO		9	51.701	109.388	−73.824	1.00	39.53	A	C
ATOM	18	CA	PRO		9	50.383	108.631	−71.933	1.00	37.44	A	C
ATOM	19	CB	PRO		9	49.554	109.522	−72.865	1.00	37.63	A	C
ATOM	20	CG	PRO		9	50.589	110.383	−73.506	1.00	39.51	A	C
ATOM	21	C	PRO		9	49.672	107.315	−71.632	1.00	35.64	A	C
ATOM	22	O	PRO		9	49.372	106.522	−72.540	1.00	33.85	A	O
ATOM	23	N	GLY		10	49.405	107.101	−70.347	1.00	33.56	A	N
ATOM	24	CA	GLY		10	48.704	105.915	−69.913	1.00	30.60	A	C
ATOM	25	C	GLY		10	49.552	104.722	−69.495	1.00	27.82	A	C
ATOM	26	O	GLY		10	49.045	103.863	−68.802	1.00	24.06	A	O
ATOM	27	N	TRP		11	50.823	104.692	−69.897	1.00	28.45	A	N
ATOM	28	CA	TRP		11	51.703	103.550	−69.584	1.00	29.12	A	C
ATOM	29	CB	TRP		11	52.855	103.473	−70.593	1.00	27.79	A	C
ATOM	30	CG	TRP		11	52.402	103.131	−71.965	1.00	26.17	A	C
ATOM	31	CD2	TRP		11	52.070	101.830	−72.458	1.00	26.93	A	C
ATOM	32	CE2	TRP		11	51.698	101.980	−73.821	1.00	26.12	A	C
ATOM	33	CE3	TRP		11	52.050	100.547	−71.883	1.00	26.02	A	C
ATOM	34	CD1	TRP		11	52.213	103.993	−73.011	1.00	26.11	A	C
ATOM	35	NE1	TRP		11	51.791	103.311	−74.125	1.00	25.99	A	N
ATOM	36	CZ2	TRP		11	51.321	100.912	−74.614	1.00	25.96	A	C
ATOM	37	CZ3	TRP		11	51.668	99.481	−72.668	1.00	25.07	A	C
ATOM	38	CH2	TRP		11	51.309	99.664	−74.029	1.00	28.08	A	C
ATOM	39	C	TRP		11	52.262	103.474	−68.170	1.00	29.92	A	C
ATOM	40	O	TRP		11	52.443	104.490	−67.499	1.00	29.95	A	O
ATOM	41	N	GLU		12	52.481	102.240	−67.696	1.00	28.77	A	N
ATOM	42	CA	GLU		12	53.039	101.986	−66.364	1.00	29.22	A	C
ATOM	43	CB	GLU		12	51.949	101.951	−65.274	1.00	31.03	A	C
ATOM	44	CG	GLU		12	51.000	100.767	−65.327	1.00	38.21	A	C
ATOM	45	CD	GLU		12	50.013	100.740	−64.153	1.00	42.00	A	C
ATOM	46	OE1	GLU		12	49.103	101.604	−64.086	1.00	43.94	A	O
ATOM	47	OE2	GLU		12	50.157	99.851	−63.289	1.00	45.85	A	O
ATOM	48	C	GLU		12	53.777	100.625	−66.382	1.00	29.39	A	C
ATOM	49	O	GLU		12	53.521	99.765	−67.235	1.00	25.12	A	O
ATOM	50	N	LYS		13	54.682	100.450	−65.435	1.00	29.42	A	N
ATOM	51	CA	LYS		13	55.449	99.218	−65.360	1.00	31.07	A	C
ATOM	52	CB	LYS		13	56.809	99.484	−64.735	1.00	35.41	A	C
ATOM	53	CG	LYS		13	57.914	99.623	−65.756	1.00	39.53	A	C
ATOM	54	CD	LYS		13	59.281	99.665	−65.050	1.00	44.11	A	C
ATOM	55	CE	LYS		13	60.412	99.472	−66.042	1.00	46.04	A	C
ATOM	56	NZ	LYS		13	61.717	99.242	−65.346	1.00	49.58	A	N
ATOM	57	C	LYS		13	54.715	98.234	−64.521	1.00	30.31	A	C
ATOM	58	O	LYS		13	54.050	98.611	−63.562	1.00	31.03	A	O
ATOM	59	N	ALA		14	54.809	96.966	−64.887	1.00	29.23	A	N
ATOM	60	CA	ALA		14	54.158	95.921	−64.124	1.00	28.03	A	C
ATOM	61	CB	ALA		14	52.819	95.520	−64.783	1.00	29.63	A	C
ATOM	62	C	ALA		14	55.119	94.726	−64.066	1.00	28.45	A	C
ATOM	63	O	ALA		14	56.160	94.703	−64.724	1.00	24.39	A	O
ATOM	64	N	MET		15	54.738	93.730	−63.290	1.00	30.12	A	N
ATOM	65	CA	MET		15	55.560	92.542	−63.137	1.00	31.95	A	C
ATOM	66	CB	MET		15	55.989	92.429	−61.686	1.00	36.28	A	C
ATOM	67	CG	MET		15	56.718	91.147	−61.387	1.00	42.59	A	C
ATOM	68	SD	MET		15	58.409	91.363	−61.896	1.00	49.52	A	S
ATOM	69	CE	MET		15	58.932	92.794	−60.774	1.00	47.65	A	C
ATOM	70	C	MET		15	54.729	91.327	−63.486	1.00	30.33	A	C
ATOM	71	O	MET		15	53.636	91.172	−62.943	1.00	27.69	A	O
ATOM	72	N	SER		16	55.234	90.472	−64.373	1.00	29.39	A	N
ATOM	73	CA	SER		16	54.512	89.245	−64.732	1.00	30.10	A	C
ATOM	74	CB	SER		16	55.280	88.449	−65.787	1.00	29.88	A	C
ATOM	75	OG	SER		16	54.726	87.135	−65.920	1.00	30.65	A	O
ATOM	76	C	SER		16	54.340	88.347	−63.504	1.00	31.27	A	C
ATOM	77	O	SER		16	55.302	88.104	−62.777	1.00	30.51	A	O
ATOM	78	N	ARG		17	53.133	87.845	−63.278	1.00	33.49	A	N
ATOM	79	CA	ARG		17	52.886	86.962	−62.137	1.00	36.89	A	C
ATOM	80	CB	ARG		17	51.389	86.837	−61.869	1.00	38.43	A	C
ATOM	81	CG	ARG		17	50.741	88.067	−61.307	1.00	40.79	A	C
ATOM	82	CD	ARG		17	51.150	88.344	−59.876	1.00	42.01	A	C
ATOM	83	NE	ARG		17	50.731	89.695	−59.494	1.00	44.30	A	N
ATOM	84	CZ	ARG		17	49.501	90.039	−59.099	1.00	44.50	A	C
ATOM	85	NH1	ARG		17	48.518	89.133	−58.997	1.00	43.97	A	N
ATOM	86	NH2	ARG		17	49.245	91.316	−58.862	1.00	44.67	A	N
ATOM	87	C	ARG		17	53.436	85.563	−62.390	1.00	38.51	A	C
ATOM	88	O	ARG		17	53.601	84.767	−61.467	1.00	38.21	A	O
ATOM	89	N	SER		18	53.691	85.259	−63.657	1.00	39.74	A	N
ATOM	90	CA	SER		18	54.200	83.945	−64.054	1.00	41.01	A	C
ATOM	91	CB	SER		18	53.646	83.560	−65.416	1.00	41.75	A	C
ATOM	92	OG	SER		18	52.278	83.311	−65.310	1.00	43.95	A	O
ATOM	93	C	SER		18	55.699	83.849	−64.151	1.00	41.06	A	C
ATOM	94	O	SER		18	56.310	82.911	−63.626	1.00	42.04	A	O
ATOM	95	N	SER		19	56.285	84.823	−64.832	1.00	39.54	A	N
ATOM	96	CA	SER		19	57.711	84.835	−65.068	1.00	38.42	A	C
ATOM	97	CB	SER		19	57.967	85.227	−66.518	1.00	39.80	A	C
ATOM	98	OG	SER		19	57.269	86.410	−66.852	1.00	39.69	A	O
ATOM	99	C	SER		19	58.503	85.741	−64.181	1.00	37.48	A	C
ATOM	100	O	SER		19	59.690	85.512	−63.965	1.00	38.01	A	O
ATOM	101	N	GLY		20	57.861	86.784	−63.667	1.00	36.08	A	N
ATOM	102	CA	GLY		20	58.588	87.722	−62.840	1.00	33.43	A	C
ATOM	103	C	GLY		20	59.238	88.762	−63.752	1.00	32.49	A	C
ATOM	104	O	GLY		20	59.903	89.695	−63.291	1.00	32.53	A	O
ATOM	105	N	ARG		21	59.067	89.611	−65.061	1.00	29.79	A	N
ATOM	106	CA	ARG		21	59.657	89.569	−65.972	1.00	27.70	A	C
ATOM	107	CB	ARG		21	59.785	88.950	−67.360	1.00	31.60	A	C
ATOM	108	CG	ARG		21	61.140	89.185	−68.040	1.00	34.43	A	C
ATOM	109	CD	ARG		21	61.105	88.693	−69.511	1.00	34.59	A	C
ATOM	110	NE	ARG		21	60.242	87.525	−69.635	1.00	35.91	A	N
ATOM	111	CZ	ARG		21	59.346	87.342	−70.603	1.00	35.58	A	C
ATOM	112	NH1	ARG		21	59.181	88.248	−71.575	1.00	33.21	A	N
ATOM	113	NH2	ARG		21	58.563	86.267	−70.553	1.00	35.31	A	N
ATOM	114	C	ARG		21	58.804	90.860	−66.037	1.00	25.50	A	C
ATOM	115	O	ARG		21	57.578	90.830	−65.926	1.00	24.14	A	O
ATOM	116	N	VAL		22	59.444	91.997	−66.203	1.00	23.36	A	N
ATOM	117	CA	VAL		22	58.645	93.220	−66.250	1.00	23.66	A	C
ATOM	118	CB	VAL		22	59.516	94.432	−66.039	1.00	24.20	A	C
ATOM	119	CG1	VAL		22	60.220	94.327	−64.678	1.00	28.27	A	C
ATOM	120	CG2	VAL		22	60.556	94.517	−67.131	1.00	27.40	A	C
ATOM	121	C	VAL		22	57.909	93.361	−67.593	1.00	21.54	A	C
ATOM	122	O	VAL		22	58.359	92.847	−68.615	1.00	20.98	A	O
ATOM	123	N	TYR		23	56.752	94.011	−67.580	1.00	20.65	A	N
ATOM	124	CA	TYR		23	56.055	94.252	−68.833	1.00	19.71	A	C
ATOM	125	CB	TYR		23	55.008	93.177	−69.134	1.00	18.59	A	C
ATOM	126	CG	TYR		23	53.838	93.150	−68.215	1.00	21.16	A	C
ATOM	127	CD1	TYR		23	52.634	93.751	−68.583	1.00	20.99	A	C
ATOM	128	CE1	TYR		23	51.518	93.667	−67.767	1.00	24.50	A	C
ATOM	129	CD2	TYR		23	53.907	92.473	−66.995	1.00	22.06	A	C
ATOM	130	CE2	TYR		23	52.797	92.384	−66.168	1.00	26.15	A	C
ATOM	131	CZ	TYR		23	51.600	92.987	−66.574	1.00	25.60	A	C
ATOM	132	OH	TYR		23	50.482	92.902	−65.796	1.00	26.07	A	O
ATOM	133	C	TYR		23	55.431	95.654	−68.682	1.00	21.65	A	C
ATOM	134	O	TYR		23	55.613	96.317	−67.654	1.00	20.50	A	O
ATOM	135	N	TYR		24	54.723	96.103	−69.699	1.00	19.39	A	N
ATOM	136	CA	TYR		24	54.159	97.448	−69.629	1.00	21.72	A	C
ATOM	137	CB	TYR		24	54.825	98.315	−70.692	1.00	24.00	A	C
ATOM	138	CG	TYR		24	56.310	98.454	−70.413	1.00	28.86	A	C
ATOM	139	CD1	TYR		24	57.224	97.476	−70.832	1.00	31.55	A	C
ATOM	140	CE1	TYR		24	58.574	97.543	−70.471	1.00	33.94	A	C
ATOM	141	CD2	TYR		24	56.776	99.501	−69.637	1.00	31.11	A	C
ATOM	142	CE2	TYR		24	58.120	99.593	−69.268	1.00	34.88	A	C
ATOM	143	CZ	TYR		24	59.009	98.608	−69.688	1.00	36.23	A	C
ATOM	144	OH	TYR		24	60.327	98.714	−69.307	1.00	38.97	A	O
ATOM	145	C	TYR		24	52.661	97.336	−69.844	1.00	19.03	A	C
ATOM	146	O	TYR		24	52.220	96.531	−70.655	1.00	18.17	A	O
ATOM	147	N	PHE		25	51.903	98.136	−69.104	1.00	19.96	A	N
ATOM	148	CA	PHE		25	50.444	98.104	−69.165	1.00	19.89	A	C
ATOM	149	CB	PHE		25	49.924	97.559	−67.837	1.00	21.97	A	C
ATOM	150	CG	PHE		25	48.456	97.671	−67.686	1.00	22.65	A	C
ATOM	151	CD1	PHE		25	47.609	96.890	−68.479	1.00	25.04	A	C
ATOM	152	CD2	PHE		25	47.901	98.611	−66.804	1.00	24.92	A	C
ATOM	153	CE1	PHE		25	46.183	97.026	−68.429	1.00	25.30	A	C
ATOM	154	CE2	PHE		25	46.490	98.764	−66.736	1.00	25.29	A	C
ATOM	155	CZ	PHE		25	45.634	97.965	−67.560	1.00	26.73	A	C
ATOM	156	C	PHE		25	49.997	99.559	−69.322	1.00	20.33	A	C
ATOM	157	O	PHE		25	50.577	100.460	−68.705	1.00	21.29	A	O
ATOM	158	N	ASN		26	48.978	99.782	−70.135	1.00	19.99	A	N
ATOM	159	CA	ASN		26	48.442	101.156	−70.343	1.00	20.03	A	C
ATOM	160	CB	ASN		26	48.400	101.486	−71.838	1.00	20.35	A	C
ATOM	161	CG	ASN		26	48.007	102.939	−72.093	1.00	20.30	A	C
ATOM	162	OD1	ASN		26	46.923	103.373	−71.680	1.00	18.74	A	O
ATOM	163	ND2	ASN		26	48.877	103.675	−72.774	1.00	20.10	A	N
ATOM	164	C	ASN		26	47.057	101.185	−69.738	1.00	17.03	A	C
ATOM	165	O	ASN		26	46.151	100.450	−70.158	1.00	16.51	A	O
ATOM	166	N	HIS		27	46.871	102.024	−68.724	1.00	16.46	A	N
ATOM	167	CA	HIS		27	45.566	102.040	−68.038	1.00	17.94	A	C
ATOM	168	CB	HIS		27	45.674	102.626	−66.619	1.00	17.75	A	C
ATOM	169	CG	HIS		27	46.254	104.000	−66.577	1.00	21.48	A	C
ATOM	170	CD2	HIS		27	45.692	105.216	−66.790	1.00	23.71	A	C
ATOM	171	ND1	HIS		27	47.571	104.240	−66.242	1.00	23.59	A	N
ATOM	172	CE1	HIS		27	47.798	105.543	−66.257	1.00	25.25	A	C
ATOM	173	NE2	HIS		27	46.675	106.157	−66.584	1.00	25.44	A	N
ATOM	174	C	HIS		27	44.460	102.798	−68.771	1.00	17.80	A	C
ATOM	175	O	HIS		27	43.352	102.865	−68.254	1.00	18.70	A	O
ATOM	176	N	ILE		28	44.772	103.365	−69.931	1.00	17.75	A	N
ATOM	177	CA	ILE		28	43.760	104.044	−70.724	1.00	18.73	A	C
ATOM	178	CB	ILE		28	44.277	105.334	−71.292	1.00	18.90	A	C
ATOM	179	CG2	ILE		28	43.156	106.025	−72.071	1.00	18.20	A	C
ATOM	180	CG1	ILE		28	44.799	106.222	−70.173	1.00	19.60	A	C
ATOM	181	CD1	ILE		28	45.624	107.418	−70.705	1.00	19.60	A	C
ATOM	182	C	ILE		28	43.274	103.159	−71.896	1.00	18.50	A	C
ATOM	183	O	ILE		28	42.087	103.139	−72.213	1.00	19.56	A	O
ATOM	184	N	THR		29	44.169	102.391	−72.507	1.00	17.97	A	N
ATOM	185	CA	THR		29	43.768	101.520	−73.629	1.00	17.64	A	C
ATOM	186	CB	THR		29	44.836	101.548	−74.708	1.00	17.16	A	C
ATOM	187	OG1	THR		29	46.006	100.939	−74.155	1.00	16.12	A	O
ATOM	188	CG2	THR		29	45.180	102.982	−75.147	1.00	18.18	A	C
ATOM	189	C	THR		29	43.641	100.024	−73.198	1.00	17.65	A	C
ATOM	190	O	THR		29	43.119	99.194	−73.961	1.00	15.71	A	O
ATOM	191	N	ASN		30	44.136	99.710	−71.985	1.00	16.99	A	N
ATOM	192	CA	ASN		30	44.211	98.339	−71.437	1.00	16.73	A	C
ATOM	193	CB	ASN		30	42.816	97.728	−71.279	1.00	17.99	A	C
ATOM	194	CG	ASN		30	42.089	98.314	−70.063	1.00	20.60	A	C
ATOM	195	OD1	ASN		30	40.852	98.465	−70.051	1.00	19.73	A	O
ATOM	196	ND2	ASN		30	42.867	98.662	−69.049	1.00	19.70	A	N
ATOM	197	C	ASN		30	45.153	97.439	−72.264	1.00	15.22	A	C
ATOM	198	O	ASN		30	45.102	96.197	−72.183	1.00	15.45	A	O
ATOM	199	N	ALA		31	46.037	98.063	−73.036	1.00	16.39	A	N
ATOM	200	CA	ALA		31	47.012	97.291	−73.811	1.00	15.60	A	C
ATOM	201	CB	ALA		31	47.695	98.166	−74.885	1.00	14.03	A	C
ATOM	202	C	ALA		31	48.104	96.792	−72.875	1.00	18.33	A	C
ATOM	203	O	ALA		31	48.447	97.468	−71.875	1.00	16.84	A	O
ATOM	204	N	SER		32	48.681	95.631	−73.186	1.00	17.05	A	N
ATOM	205	CA	SER		32	49.823	95.169	−72.392	1.00	18.60	A	C
ATOM	206	CB	SER		32	49.423	94.162	−71.314	1.00	18.58	A	C
ATOM	207	OG	SER		32	48.566	93.155	−71.782	1.00	21.59	A	O
ATOM	208	C	SER		32	50.866	94.576	−73.343	1.00	19.74	A	C
ATOM	209	O	SER		32	50.506	93.946	−74.328	1.00	19.91	A	O
ATOM	210	N	GLN		33	52.147	94.817	−73.081	1.00	20.71	A	N
ATOM	211	CA	GLN		33	53.188	94.286	−73.953	1.00	21.40	A	C
ATOM	212	CB	GLN		33	53.450	95.245	−75.117	1.00	21.56	A	C
ATOM	213	CG	GLN		33	53.840	96.646	−74.684	1.00	26.07	A	C
ATOM	214	CD	GLN		33	54.032	97.581	−75.876	1.00	31.95	A	C
ATOM	215	OE1	GLN		33	54.935	98.444	−75.899	1.00	32.77	A	O
ATOM	216	NE2	GLN		33	53.169	97.424	−76.866	1.00	33.72	A	N
ATOM	217	C	GLN		33	54.486	94.104	−73.156	1.00	23.24	A	C
ATOM	218	O	GLN		33	54.689	94.755	−72.134	1.00	20.88	A	O
ATOM	219	N	TRP		34	55.364	93.219	−73.637	1.00	24.29	A	N
ATOM	220	CA	TRP		34	56.668	93.021	−72.963	1.00	23.41	A	C
ATOM	221	CB	TRP		34	57.342	91.721	−73.458	1.00	22.12	A	C
ATOM	222	CG	TRP		34	56.627	90.467	−73.042	1.00	19.46	A	C
ATOM	223	CD2	TRP		34	56.455	89.973	−71.713	1.00	20.92	A	C
ATOM	224	CE2	TRP		34	55.689	88.808	−71.807	1.00	20.79	A	C
ATOM	225	CE3	TRP		34	56.880	90.408	−70.447	1.00	20.24	A	C
ATOM	226	CD1	TRP		34	55.984	89.602	−73.851	1.00	19.94	A	C
ATOM	227	NE1	TRP		34	55.428	88.608	−73.134	1.00	23.04	A	N
ATOM	228	CZ2	TRP		34	55.321	88.051	−70.690	1.00	23.58	A	C
ATOM	229	CZ3	TRP		34	56.515	89.661	−69.335	1.00	21.37	A	C
ATOM	230	CH2	TRP		34	55.743	88.497	−69.462	1.00	22.61	A	C
ATOM	231	C	TRP		34	57.599	94.201	−73.261	1.00	26.89	A	C
ATOM	232	O	TRP		34	58.287	94.706	−72.391	1.00	24.04	A	O
ATOM	233	N	GLU		35	57.604	94.633	−74.514	1.00	30.77	A	N
ATOM	234	CA	GLU		35	58.468	95.709	−74.971	1.00	36.06	A	C
ATOM	235	CB	GLU		35	58.374	95.790	−76.506	1.00	39.46	A	C
ATOM	236	CG	GLU		35	58.593	94.439	−77.249	1.00	42.44	A	C
ATOM	237	CD	GLU		35	57.397	93.493	−77.249	1.00	44.78	A	C
ATOM	238	OE1	GLU		35	57.598	92.298	−77.603	1.00	44.98	A	O
ATOM	239	OE2	GLU		35	56.267	93.932	−76.902	1.00	42.57	A	O
ATOM	240	C	GLU		35	58.179	97.065	−74.349	1.00	38.85	A	C
ATOM	241	O	GLU		35	57.020	97.420	−74.105	1.00	38.53	A	O
ATOM	242	N	ARG		36	59.225	97.828	−74.065	1.00	41.91	A	N
ATOM	243	CA	ARG		36	59.014	99.142	−73.484	1.00	45.70	A	C
ATOM	244	CB	ARG		36	60.337	99.764	−73.045	1.00	47.04	A	C
ATOM	245	CG	ARG		36	60.168	100.953	−72.104	1.00	49.42	A	C
ATOM	246	CD	ARG		36	61.453	101.188	−71.299	1.00	52.01	A	C
ATOM	247	NE	ARG		36	61.296	102.105	−70.166	1.00	53.09	A	N
ATOM	248	CZ	ARG		36	61.202	103.430	−70.275	1.00	54.34	A	C
ATOM	249	NH1	ARG		36	61.248	104.014	−71.474	1.00	54.73	A	N
ATOM	250	NH2	ARG		36	61.065	104.173	−69.181	1.00	54.52	A	N
ATOM	251	C	ARG		36	58.345	99.990	−74.571	1.00	47.26	A	C
ATOM	252	O	ARG		36	58.752	99.966	−75.743	1.00	47.67	A	O
ATOM	253	N	PRO		37	57.294	100.737	−74.197	1.00	48.38	A	N
ATOM	254	CD	PRO		37	56.760	100.921	−72.833	1.00	47.75	A	C
ATOM	255	CA	PRO		37	56.572	101.581	−75.153	1.00	49.26	A	C
ATOM	256	CB	PRO		37	55.342	102.005	−74.366	1.00	48.18	A	C
ATOM	257	CG	PRO		37	55.883	102.155	−72.996	1.00	48.85	A	C
ATOM	258	C	PRO		37	57.366	102.772	−75.667	1.00	50.39	A	C
ATOM	259	O	PRO		37	58.022	103.487	−74.884	1.00	50.55	A	O
ATOM	260	N	SER		38	57.270	102.974	−76.985	1.00	51.87	A	N
ATOM	261	CA	SER		38	57.940	104.057	−77.714	1.00	53.51	A	C
ATOM	262	CB	SER		38	58.390	103.559	−79.097	1.00	54.83	A	C
ATOM	263	OG	SER		38	57.285	103.149	−79.901	1.00	55.33	A	O
ATOM	264	C	SER		38	57.056	105.294	−77.902	1.00	53.14	A	C
ATOM	265	O	SER		38	55.911	105.336	−77.452	1.00	52.91	A	O
ATOM	266	N	GLU		51	49.209	115.419	−78.922	1.00	57.18	A	N
ATOM	267	CA	GLU		51	48.450	114.425	−79.670	1.00	56.76	A	C
ATOM	268	CB	GLU		51	47.325	113.852	−78.800	1.00	57.06	A	C
ATOM	269	CG	GLU		51	46.148	114.799	−78.627	1.00	56.37	A	C
ATOM	270	CD	GLU		51	45.028	114.202	−77.794	1.00	55.93	A	C
ATOM	271	OE1	GLU		51	45.304	113.389	−76.877	1.00	55.39	A	O
ATOM	272	OE2	GLU		51	43.865	114.566	−78.041	1.00	55.53	A	O
ATOM	273	C	GLU		51	47.828	115.043	−80.920	1.00	56.21	A	C
ATOM	274	O	GLU		51	47.691	116.264	−81.024	1.00	56.71	A	O
ATOM	275	N	PRO		52	47.426	114.193	−81.885	1.00	55.50	A	N
ATOM	276	CD	PRO		52	47.674	112.739	−81.850	1.00	55.06	A	C
ATOM	277	CA	PRO		52	46.799	114.593	−83.159	1.00	53.57	A	C
ATOM	278	CB	PRO		52	46.896	113.326	−83.996	1.00	54.59	A	C
ATOM	279	CG	PRO		52	46.753	112.233	−82.936	1.00	55.33	A	C
ATOM	280	C	PRO		52	45.343	115.073	−83.006	1.00	51.62	A	C
ATOM	281	O	PRO		52	44.654	114.703	−82.048	1.00	52.15	A	O
ATOM	282	N	ALA		53	44.893	115.889	−83.958	1.00	48.32	A	N
ATOM	283	CA	ALA		53	43.542	116.429	−83.966	1.00	45.39	A	C
ATOM	284	CB	ALA		53	43.419	117.505	−85.043	1.00	46.60	A	C
ATOM	285	C	ALA		53	42.533	115.325	−84.233	1.00	42.66	A	C
ATOM	286	O	ALA		53	41.390	115.358	−83.750	1.00	40.93	A	O
ATOM	287	N	ARG		54	42.939	114.351	−85.040	1.00	40.42	A	N
ATOM	288	CA	ARG		54	42.045	113.246	−85.349	1.00	36.45	A	C
ATOM	289	CB	ARG		54	41.251	113.519	−86.630	1.00	40.21	A	C
ATOM	290	CG	ARG		54	40.899	114.989	−86.886	1.00	44.89	A	C
ATOM	291	CD	ARG		54	40.238	115.137	−88.252	1.00	47.53	A	C
ATOM	292	NE	ARG		54	38.839	114.737	−88.196	1.00	50.86	A	N
ATOM	293	CZ	ARG		54	38.175	114.214	−89.222	1.00	53.11	A	C
ATOM	294	NH1	ARG		54	38.798	114.023	−90.383	1.00	53.57	A	N
ATOM	295	NH2	ARG		54	36.882	113.902	−89.095	1.00	54.45	A	N
ATOM	296	C	ARG		54	42.830	111.958	−85.522	1.00	32.29	A	C
ATOM	297	O	ARG		54	44.053	111.953	−85.739	1.00	31.13	A	O
ATOM	298	N	VAL		55	42.107	110.865	−85.383	1.00	27.12	A	N
ATOM	299	CA	VAL		55	42.686	109.548	−85.567	1.00	24.51	A	C
ATOM	300	CB	VAL		55	42.991	108.855	−84.192	1.00	22.55	A	C
ATOM	301	CG1	VAL		55	43.986	109.705	−83.379	1.00	21.99	A	C
ATOM	302	CG2	VAL		55	41.718	108.674	−83.399	1.00	21.28	A	C
ATOM	303	C	VAL		55	41.622	108.746	−86.314	1.00	23.57	A	C
ATOM	304	O	VAL		55	40.447	109.142	−86.374	1.00	25.42	A	O
ATOM	305	N	ARG		56	42.046	107.653	−86.922	1.00	20.61	A	N
ATOM	306	CA	ARG		56	41.126	106.781	−87.585	1.00	19.73	A	C
ATOM	307	CB	ARG		56	41.509	106.633	−89.052	1.00	21.17	A	C
ATOM	308	CG	ARG		56	40.532	105.747	−89.800	1.00	21.29	A	C
ATOM	309	CD	ARG		56	40.922	105.617	−91.285	1.00	23.33	A	C
ATOM	310	NE	ARG		56	39.929	104.837	−92.041	1.00	24.93	A	N
ATOM	311	CZ	ARG		56	40.074	104.542	−93.331	1.00	28.00	A	C
ATOM	312	NH1	ARG		56	41.171	104.967	−93.974	1.00	27.95	A	N
ATOM	313	NH2	ARG		56	39.131	103.866	−93.983	1.00	26.57	A	N
ATOM	314	C	ARG		56	41.248	105.433	−86.864	1.00	19.23	A	C
ATOM	315	O	ARG		56	42.354	104.988	−86.591	1.00	18.91	A	O
ATOM	316	N	CYS		57	40.125	104.796	−86.545	1.00	18.32	A	N
ATOM	317	CA	CYS		57	40.167	103.512	−85.866	1.00	18.91	A	C
ATOM	318	CB	CYS		57	39.850	103.691	−84.362	1.00	17.51	A	C
ATOM	319	SG	CYS		57	41.115	104.631	−83.467	1.00	19.22	A	S
ATOM	320	C	CYS		57	39.173	102.555	−86.429	1.00	18.65	A	C
ATOM	321	O	CYS		57	38.209	102.973	−87.078	1.00	18.74	A	O
ATOM	322	N	SER		58	39.449	101.264	−86.230	1.00	15.34	A	N
ATOM	323	CA	SER		58	38.516	100.212	−86.510	1.00	14.85	A	C
ATOM	324	CB	SER		58	39.100	99.128	−87.415	1.00	15.27	A	C
ATOM	325	OG	SER		58	39.344	99.696	−88.683	1.00	16.58	A	O
ATOM	326	C	SER		58	38.284	99.619	−85.102	1.00	16.36	A	C
ATOM	327	O	SER		58	39.099	99.885	−84.168	1.00	16.10	A	O
ATOM	328	N	HIS		59	37.208	98.830	−84.944	1.00	14.27	A	N
ATOM	329	CA	HIS		59	36.911	98.178	−83.684	1.00	16.12	A	C
ATOM	330	CB	HIS		59	36.137	99.111	−82.735	1.00	17.98	A	C
ATOM	331	CG	HIS		59	34.692	99.304	−83.109	1.00	19.80	A	C
ATOM	332	CD2	HIS		59	34.091	99.490	−84.312	1.00	20.67	A	C
ATOM	333	ND1	HIS		59	33.677	99.307	−82.172	1.00	22.45	A	N
ATOM	334	CE1	HIS		59	32.516	99.484	−82.784	1.00	23.18	A	C
ATOM	335	NE2	HIS		59	32.736	99.598	−84.082	1.00	21.45	A	N
ATOM	336	C	HIS		59	36.135	96.894	−83.853	1.00	15.59	A	C
ATOM	337	O	HIS		59	35.561	96.613	−84.911	1.00	16.30	A	O
ATOM	338	N	LEU		60	36.123	96.096	−82.795	1.00	15.71	A	N
ATOM	339	CA	LEU		60	35.361	94.877	−82.785	1.00	15.37	A	C
ATOM	340	CB	LEU		60	36.272	93.650	−82.764	1.00	14.76	A	C
ATOM	341	CG	LEU		60	35.571	92.283	−82.913	1.00	14.78	A	C
ATOM	342	CD1	LEU		60	36.665	91.248	−83.255	1.00	15.94	A	C
ATOM	343	CD2	LEU		60	34.776	91.858	−81.625	1.00	14.00	A	C
ATOM	344	C	LEU		60	34.606	95.015	−81.466	1.00	16.89	A	C
ATOM	345	O	LEU		60	35.196	95.105	−80.375	1.00	16.94	A	O
ATOM	346	N	LEU		61	33.294	95.026	−81.561	1.00	16.34	A	N
ATOM	347	CA	LEU		61	32.443	95.195	−80.389	1.00	17.70	A	C
ATOM	348	CB	LEU		61	31.347	96.237	−80.726	1.00	19.58	A	C
ATOM	349	CG	LEU		61	30.275	96.422	−79.621	1.00	20.38	A	C
ATOM	350	CD1	LEU		61	30.927	96.933	−78.351	1.00	21.58	A	C
ATOM	351	CD2	LEU		61	29.189	97.410	−80.084	1.00	22.24	A	C
ATOM	352	C	LEU		61	31.766	93.888	−80.011	1.00	16.77	A	C
ATOM	353	O	LEU		61	31.257	93.188	−80.883	1.00	16.83	A	O
ATOM	354	N	VAL		62	31.796	93.534	−78.719	1.00	16.21	A	N
ATOM	355	CA	VAL		62	31.072	92.369	−78.280	1.00	16.86	A	C
ATOM	356	CB	VAL		62	31.958	91.257	−77.666	1.00	18.07	A	C
ATOM	357	CG1	VAL		62	31.043	90.159	−77.040	1.00	19.04	A	C
ATOM	358	CG2	VAL		62	32.853	90.637	−78.760	1.00	17.25	A	C
ATOM	359	C	VAL		62	30.108	92.918	−77.219	1.00	19.42	A	C
ATOM	360	O	VAL		62	30.517	93.485	−76.192	1.00	17.73	A	O
ATOM	361	N	LYS		63	28.822	92.798	−77.528	1.00	20.54	A	N
ATOM	362	CA	LYS		63	27.754	93.288	−76.656	1.00	23.25	A	C
ATOM	363	CB	LYS		63	26.504	93.624	−77.509	1.00	23.31	A	C
ATOM	364	CG	LYS		63	26.658	94.923	−78.317	1.00	25.42	A	C
ATOM	365	CD	LYS		63	25.334	95.370	−79.028	1.00	24.98	A	C
ATOM	366	CE	LYS		63	25.397	96.825	−79.373	1.00	25.17	A	C
ATOM	367	NZ	LYS		63	24.153	97.364	−79.994	1.00	26.49	A	N
ATOM	368	C	LYS		63	27.405	92.240	−75.616	1.00	23.80	A	C
ATOM	369	O	LYS		63	27.785	91.081	−75.742	1.00	22.62	A	O
ATOM	370	N	HIS		64	26.722	92.666	−74.555	1.00	25.65	A	N
ATOM	371	CA	HIS		64	26.285	91.744	−73.526	1.00	27.03	A	C
ATOM	372	CE	HIS		64	27.299	91.653	−72.379	1.00	25.01	A	C
ATOM	373	CG	HIS		64	27.759	92.979	−71.877	1.00	27.44	A	C
ATOM	374	CD2	HIS		64	28.914	93.656	−72.091	1.00	27.72	A	C
ATOM	375	ND1	HIS		64	26.968	93.802	−71.107	1.00	27.68	A	N
ATOM	376	CE1	HIS		64	27.615	94.930	−70.869	1.00	29.90	A	C
ATOM	377	NE2	HIS		64	28.799	94.865	−71.457	1.00	29.44	A	N
ATOM	378	C	HIS		64	24.918	92.210	−73.016	1.00	28.64	A	C
ATOM	379	O	HIS		64	24.411	93.265	−73.428	1.00	28.23	A	O
ATOM	380	N	SER		65	24.332	91.421	−72.122	1.00	31.14	A	N
ATOM	381	CA	SER		65	22.991	91.720	−71.594	1.00	32.46	A	C
ATOM	382	CB	SER		65	22.559	90.610	−70.630	1.00	32.73	A	C
ATOM	383	OG	SER		65	23.329	90.701	−69.454	1.00	34.51	A	O
ATOM	384	C	SER		65	22.834	93.092	−70.930	1.00	33.00	A	C
ATOM	385	O	SER		65	21.715	93.600	−70.819	1.00	34.17	A	O
ATOM	386	N	GLN		66	23.917	93.709	−70.477	1.00	31.75	A	N
ATOM	387	CA	GLN		66	23.774	95.038	−69.890	1.00	32.98	A	C
ATOM	388	CB	GLN		66	24.635	95.212	−68.629	1.00	36.13	A	C
ATOM	389	CG	GLN		66	24.134	94.486	−67.372	1.00	40.19	A	C
ATOM	390	CD	GLN		66	24.997	94.835	−66.128	1.00	44.56	A	C
ATOM	391	OE1	GLN		66	24.915	95.956	−65.582	1.00	44.70	A	O
ATOM	392	NE2	GLN		66	25.842	93.886	−65.705	1.00	44.23	A	N
ATOM	393	C	GLN		66	24.132	96.153	−70.872	1.00	32.44	A	C
ATOM	394	O	GLN		66	24.233	97.309	−70.469	1.00	34.82	A	O
ATOM	395	N	SER		67	24.351	95.827	−72.148	1.00	31.99	A	N
ATOM	396	CA	SER		67	24.662	96.868	−73.136	1.00	32.31	A	C
ATOM	397	CB	SER		67	24.995	96.253	−74.494	1.00	32.03	A	C
ATOM	398	OG	SER		67	26.245	95.613	−74.475	1.00	29.96	A	O
ATOM	399	C	SER		67	23.449	97.776	−73.314	1.00	33.99	A	C
ATOM	400	O	SER		67	22.316	97.291	−73.323	1.00	33.76	A	O
ATOM	401	N	ARG		68	23.697	99.071	−73.495	1.00	35.83	A	N
ATOM	402	CA	ARG		68	22.616	100.037	−73.676	1.00	39.36	A	C
ATOM	403	CB	ARG		68	23.166	101.348	−74.236	1.00	40.70	A	C
ATOM	404	CG	ARG		68	22.250	102.585	−74.079	1.00	44.65	A	C
ATOM	405	CD	ARG		68	21.685	102.775	−72.658	1.00	46.83	A	C
ATOM	406	NE	ARG		68	22.693	102.918	−71.601	1.00	49.24	A	N
ATOM	407	CZ	ARG		68	22.393	102.960	−70.298	1.00	50.09	A	C
ATOM	408	NE1	ARG		68	21.120	102.874	−69.914	1.00	50.48	A	N
ATOM	409	NH2	ARG		68	23.349	103.067	−69.376	1.00	48.03	A	N
ATOM	410	C	ARG		68	21.566	99.444	−74.611	1.00	41.07	A	C
ATOM	411	O	ARG		68	20.357	99.579	−74.365	1.00	42.13	A	O
ATOM	412	N	ARG		69	22.011	98.766	−75.672	1.00	40.46	A	N
ATOM	413	CA	ARG		69	21.079	98.134	−76.607	1.00	39.68	A	C
ATOM	414	CB	ARG		69	21.008	98.959	−77.896	1.00	42.24	A	C
ATOM	415	CG	ARG		69	19.924	98.496	−78.850	1.00	46.49	A	C
ATOM	416	CD	ARG		69	20.034	99.176	−80.218	1.00	49.68	A	C
ATOM	417	NE	ARG		69	19.828	98.223	−81.321	1.00	52.37	A	N
ATOM	418	CZ	ARG		69	20.755	97.921	−82.236	1.00	53.19	A	C
ATOM	419	NH1	ARG		69	21.954	98.504	−82.179	1.00	52.88	A	N
ATOM	420	NH2	ARG		69	20.493	97.037	−83.205	1.00	53.10	A	N
ATOM	421	C	ARG		69	21.507	96.678	−76.897	1.00	37.70	A	C
ATOM	422	O	ARG		69	22.292	96.415	−77.808	1.00	36.77	A	O
ATOM	423	N	PRO		70	20.993	95.713	−76.111	1.00	36.30	A	N
ATOM	424	CD	PRO		70	20.097	95.941	−74.966	1.00	36.12	A	C
ATOM	425	CA	PRO		70	21.304	94.279	−76.246	1.00	35.56	A	C
ATOM	426	CB	PRO		70	20.672	93.674	−74.988	1.00	36.73	A	C
ATOM	427	CG	PRO		70	19.520	94.578	−74.736	1.00	35.81	A	C
ATOM	428	C	PRO		70	20.803	93.633	−77.536	1.00	34.10	A	C
ATOM	429	O	PRO		70	20.082	92.630	−77.520	1.00	32.97	A	O
ATOM	430	N	SER		71	21.237	94.185	−78.665	1.00	31.96	A	N
ATOM	431	CA	SER		71	20.791	93.679	−79.953	1.00	30.21	A	C
ATOM	432	CB	SER		71	19.421	94.306	−80.256	1.00	30.35	A	C
ATOM	433	OG	SER		71	19.105	94.177	−81.615	1.00	34.54	A	O
ATOM	434	C	SER		71	21.792	94.081	−81.024	1.00	28.83	A	C
ATOM	435	O	SER		71	22.439	95.108	−80.872	1.00	30.56	A	O
ATOM	436	N	SER		72	21.942	93.271	−82.070	1.00	28.37	A	N
ATOM	437	CA	SER		72	22.866	93.593	−83.183	1.00	27.81	A	C
ATOM	438	CB	SER		72	24.324	93.238	−82.826	1.00	26.47	A	C
ATOM	439	OG	SER		72	24.548	91.845	−82.900	1.00	23.77	A	O
ATOM	440	C	SER		72	22.483	92.824	−84.431	1.00	27.70	A	C
ATOM	441	O	SER		72	21.604	91.963	−84.386	1.00	26.94	A	O
ATOM	442	N	TRP		73	23.170	93.119	−85.539	1.00	27.27	A	N
ATOM	443	CA	TRP		73	22.921	92.441	−86.786	1.00	26.26	A	C
ATOM	444	CB	TRP		73	23.792	93.007	−87.920	1.00	27.78	A	C
ATOM	445	CG	TRP		73	25.310	92.698	−87.796	1.00	27.28	A	C
ATOM	446	CD2	TRP		73	26.000	91.521	−88.260	1.00	28.37	A	C
ATOM	447	CE2	TRP		73	27.361	91.657	−87.890	1.00	27.09	A	C
ATOM	448	CE3	TRP		73	25.603	90.360	−88.946	1.00	28.76	A	C
ATOM	449	CD1	TRP		73	26.264	93.482	−87.182	1.00	26.53	A	C
ATOM	450	NE1	TRP		73	27.492	92.854	−87.236	1.00	26.50	A	N
ATOM	451	CZ2	TRP		73	28.323	90.673	−88.185	1.00	27.92	A	C
ATOM	452	CZ3	TRP		73	26.568	89.389	−89.234	1.00	29.51	A	C
ATOM	453	CH2	TRP		73	27.909	89.557	−88.850	1.00	28.96	A	C
ATOM	454	C	TRP		73	23.219	90.966	−86.623	1.00	25.59	A	C
ATOM	455	O	TRP		73	22.769	90.178	−87.422	1.00	25.81	A	O
ATOM	456	N	ARG		74	23.984	90.585	−85.591	1.00	25.58	A	N
ATOM	457	CA	ARG		74	24.318	89.186	−85.423	1.00	25.70	A	C
ATOM	458	CB	ARG		74	25.641	88.974	−84.657	1.00	25.07	A	C
ATOM	459	CG	ARG		74	26.844	89.705	−85.242	1.00	25.70	A	C
ATOM	460	CD	ARG		74	28.117	89.182	−84.542	1.00	23.97	A	C
ATOM	461	NE	ARG		74	28.219	87.793	−84.902	1.00	24.15	A	N
ATOM	462	CZ	ARG		74	28.577	86.800	−84.110	1.00	27.45	A	C
ATOM	463	NH1	ARG		74	28.893	87.016	−82.841	1.00	29.21	A	N
ATOM	464	NH2	ARG		74	28.628	85.568	−84.623	1.00	29.07	A	N
ATOM	465	C	ARG		74	23.241	88.432	−84.693	1.00	26.35	A	C
ATOM	466	O	ARG		74	23.081	87.250	−84.916	1.00	25.66	A	O
ATOM	467	N	GLN		75	22.555	89.092	−83.773	1.00	27.95	A	N
ATOM	468	CA	GLN		75	21.472	88.424	−83.071	1.00	30.67	A	C
ATOM	469	CB	GLN		75	21.968	87.406	−82.041	1.00	33.29	A	C
ATOM	470	CG	GLN		75	22.933	87.909	−81.045	1.00	38.39	A	C
ATOM	471	CD	GLN		75	23.171	86.916	−79.906	1.00	40.83	A	C
ATOM	472	OE1	GLN		75	24.094	87.084	−79.123	1.00	42.06	A	O
ATOM	473	NE2	GLN		75	22.325	85.888	−79.807	1.00	41.95	A	N
ATOM	474	C	GLN		75	20.555	89.444	−82.436	1.00	30.27	A	C
ATOM	475	O	GLN		75	20.999	90.384	−81.764	1.00	29.85	A	O
ATOM	476	N	GLU		76	19.265	89.221	−82.673	1.00	28.72	A	N
ATOM	477	CA	GLU		76	18.215	90.112	−82.243	1.00	27.36	A	C
ATOM	478	CB	GLU		76	16.863	89.594	−82.742	1.00	27.38	A	C
ATOM	479	CG	GLU		76	15.697	90.576	−82.466	1.00	29.30	A	C
ATOM	480	CD	GLU		76	14.499	90.336	−83.397	1.00	28.66	A	C
ATOM	481	OE1	GLU		76	13.651	91.256	−83.523	1.00	30.39	A	O
ATOM	482	OE2	GLU		76	14.422	89.240	−83.994	1.00	28.30	A	O
ATOM	483	C	GLU		76	18.175	90.389	−80.759	1.00	28.25	A	C
ATOM	484	O	GLU		76	18.032	91.555	−80.357	1.00	27.45	A	O
ATOM	485	N	LYS		77	18.293	89.345	−79.947	1.00	28.62	A	N
ATOM	486	CA	LYS		77	18.301	89.514	−78.495	1.00	31.45	A	C
ATOM	487	CB	LYS		77	17.206	88.641	−77.864	1.00	33.56	A	C
ATOM	488	CG	LYS		77	17.213	88.609	−76.334	1.00	37.19	A	C
ATOM	489	CD	LYS		77	16.092	87.688	−75.823	1.00	39.33	A	C
ATOM	490	CE	LYS		77	15.841	87.863	−74.322	1.00	40.79	A	C
ATOM	491	NZ	LYS		77	15.635	89.295	−73.928	1.00	42.89	A	N
ATOM	492	C	LYS		77	19.677	89.041	−77.980	1.00	31.79	A	C
ATOM	493	O	LYS		77	19.943	87.841	−77.975	1.00	31.80	A	O
ATOM	494	N	ILE		78	20.539	89.959	−77.558	1.00	32.18	A	N
ATOM	495	CA	ILE		78	21.858	89.546	−77.044	1.00	32.83	A	C
ATOM	496	CB	ILE		78	22.887	90.688	−77.086	1.00	32.42	A	C
ATOM	497	CG2	ILE		78	24.184	90.235	−76.374	1.00	31.44	A	C
ATOM	498	CG1	ILE		78	23.112	91.176	−78.525	1.00	33.60	A	C
ATOM	499	CD1	ILE		78	24.010	90.342	−79.327	1.00	34.34	A	C
ATOM	500	C	ILE		78	21.652	89.189	−75.566	1.00	32.54	A	C
ATOM	501	O	ILE		78	21.245	90.046	−74.780	1.00	33.58	A	O
ATOM	502	N	THR		79	21.987	87.963	−75.195	1.00	32.18	A	N
ATOM	503	CA	THR		79	21.824	87.479	−73.830	1.00	33.05	A	C
ATOM	504	CB	THR		79	20.977	86.194	−73.852	1.00	34.01	A	C
ATOM	505	OG1	THR		79	21.623	85.218	−74.670	1.00	33.99	A	O
ATOM	506	CG2	THR		79	19.597	86.473	−74.425	1.00	35.01	A	C
ATOM	507	C	THR		79	23.104	87.157	−73.032	1.00	33.80	A	C
ATOM	508	O	THR		79	23.053	86.984	−71.806	1.00	32.58	A	O
ATOM	509	N	ARG		80	24.249	87.034	−73.709	1.00	32.26	A	N
ATOM	510	CA	ARG		80	25.488	86.718	−72.991	1.00	29.63	A	C
ATOM	511	CB	ARG		80	26.674	86.693	−73.974	1.00	28.73	A	C
ATOM	512	CG	ARG		80	27.100	88.081	−74.521	1.00	27.80	A	C
ATOM	513	CD	ARG		80	28.417	87.939	−75.327	1.00	23.69	A	C
ATOM	514	NE	ARG		80	28.204	87.284	−76.633	1.00	21.30	A	N
ATOM	515	CZ	ARG		80	27.807	87.918	−77.743	1.00	20.50	A	C
ATOM	516	NH1	ARG		80	27.579	89.219	−77.725	1.00	22.26	A	N
ATOM	517	NH2	ARG		80	27.639	87.243	−78.888	1.00	24.11	A	N
ATOM	518	C	ARG		80	25.762	87.706	−71.866	1.00	28.69	A	C
ATOM	519	O	ARG		80	25.391	88.882	−71.942	1.00	29.22	A	O
ATOM	520	N	THR		81	26.413	87.232	−70.809	1.00	28.17	A	N
ATOM	521	CA	THR		81	26.770	88.109	−69.707	1.00	28.43	A	C
ATOM	522	CB	THR		81	27.127	87.330	−68.431	1.00	29.64	A	C
ATOM	523	OG1	THR		81	28.303	86.528	−68.658	1.00	28.86	A	O
ATOM	524	CG2	THR		81	25.949	86.435	−68.024	1.00	31.24	A	C
ATOM	525	C	THR		81	27.995	88.947	−70.064	1.00	27.38	A	C
ATOM	526	O	THR		81	28.707	88.654	−71.026	1.00	24.99	A	O
ATOM	527	N	LYS		82	28.208	89.993	−69.292	1.00	26.25	A	N
ATOM	528	CA	LYS		82	29.358	90.869	−69.474	1.00	28.43	A	C
ATOM	529	CB	LYS		82	29.328	91.998	−68.445	1.00	30.62	A	C
ATOM	530	CG	LYS		82	30.500	92.969	−68.552	1.00	36.28	A	C
ATOM	531	CD	LYS		82	30.663	93.851	−67.293	1.00	40.60	A	C
ATOM	532	CE	LYS		82	29.409	94.672	−67.011	1.00	43.01	A	C
ATOM	533	NZ	LYS		82	29.540	95.526	−65.796	1.00	44.43	A	N
ATOM	534	C	LYS		82	30.646	90.033	−69.308	1.00	28.17	A	C
ATOM	535	O	LYS		82	31.633	90.226	−70.020	1.00	25.71	A	O
ATOM	536	N	GLU		83	30.624	89.076	−68.384	1.00	26.83	A	N
ATOM	537	CA	GLU		83	31.792	88.237	−68.187	1.00	27.51	A	C
ATOM	538	CB	GLU		83	31.624	87.370	−66.923	1.00	30.84	A	C
ATOM	539	CG	GLU		83	31.553	88.171	−65.639	1.00	36.69	A	C
ATOM	540	CD	GLU		83	30.277	89.053	−65.493	1.00	41.12	A	C
ATOM	541	OE1	GLU		83	30.343	90.022	−64.697	1.00	43.82	A	O
ATOM	542	OE2	GLU		83	29.223	88.789	−66.138	1.00	40.61	A	O
ATOM	543	C	GLU		83	32.081	87.335	−69.387	1.00	25.09	A	C
ATOM	544	O	GLU		83	33.240	87.120	−69.728	1.00	22.09	A	O
ATOM	545	N	GLU		84	31.038	86.800	−70.024	1.00	23.73	A	N
ATOM	546	CA	GLU		84	31.190	85.919	−71.181	1.00	22.95	A	C
ATOM	547	CB	GLU		84	29.848	85.284	−71.553	1.00	23.71	A	C
ATOM	548	CG	GLU		84	29.357	84.217	−70.591	1.00	29.98	A	C
ATOM	549	CD	GLU		84	27.934	83.753	−70.897	1.00	31.29	A	C
ATOM	550	OE1	GLU		84	27.057	84.631	−71.125	1.00	31.31	A	O
ATOM	551	OE2	GLU		84	27.710	82.516	−70.902	1.00	32.34	A	O
ATOM	552	C	GLU		84	31.677	86.764	−72.378	1.00	22.85	A	C
ATOM	553	O	GLU		84	32.456	86.308	−73.234	1.00	21.98	A	O
ATOM	554	N	ALA		85	31.147	87.973	−72.460	1.00	20.86	A	N
ATOM	555	CA	ALA		85	31.560	88.899	−73.513	1.00	21.57	A	C
ATOM	556	CB	ALA		85	30.785	90.189	−73.405	1.00	21.75	A	C
ATOM	557	C	ALA		85	33.065	89.193	−73.342	1.00	21.21	A	C
ATOM	558	O	ALA		85	33.830	89.256	−74.330	1.00	18.50	A	O
ATOM	559	N	LEU		86	33.484	89.420	−72.099	1.00	19.89	A	N
ATOM	560	CA	LEU		86	34.902	89.710	−71.884	1.00	19.31	A	C
ATOM	561	CB	LEU		86	35.158	90.096	−70.438	1.00	18.18	A	C
ATOM	562	CG	LEU		86	36.644	90.291	−70.024	1.00	21.44	A	C
ATOM	563	CD1	LEU		86	37.321	91.300	−70.950	1.00	21.16	A	C
ATOM	564	CD2	LEU		86	36.684	90.836	−68.580	1.00	22.24	A	C
ATOM	565	C	LEU		86	35.740	88.480	−72.287	1.00	20.01	A	C
ATOM	566	O	LEU		86	36.824	88.617	−72.881	1.00	18.95	A	O
ATOM	567	N	GLU		87	35.249	87.280	−71.983	1.00	21.21	A	N
ATOM	568	CA	GLU		87	36.035	86.102	−72.348	1.00	23.45	A	C
ATOM	569	CB	GLU		87	35.455	84.796	−71.778	1.00	26.82	A	C
ATOM	570	CG	GLU		87	35.403	84.730	−70.237	1.00	35.81	A	C
ATOM	571	CD	GLU		87	36.113	85.892	−69.493	1.00	41.42	A	C
ATOM	572	OE1	GLU		87	37.352	86.104	−69.706	1.00	46.73	A	O
ATOM	573	OE2	GLU		87	35.432	86.582	−68.662	1.00	43.01	A	O
ATOM	574	C	GLU		87	36.186	85.991	−73.863	1.00	23.05	A	C
ATOM	575	O	GLU		87	37.267	85.593	−74.352	1.00	20.62	A	O
ATOM	576	N	LEU		88	35.126	86.332	−74.605	1.00	19.34	A	N
ATOM	577	CA	LEU		88	35.194	86.292	−76.062	1.00	20.09	A	C
ATOM	578	CB	LEU		88	33.831	86.629	−76.691	1.00	20.82	A	C
ATOM	579	CG	LEU		88	32.813	85.475	−76.628	1.00	22.90	A	C
ATOM	580	CD1	LEU		88	31.385	86.026	−76.718	1.00	22.73	A	C
ATOM	581	CD2	LEU		88	33.105	84.479	−77.755	1.00	24.12	A	C
ATOM	582	C	LEU		88	36.221	87.306	−76.569	1.00	18.41	A	C
ATOM	583	O	LEU		88	37.032	86.993	−77.461	1.00	17.91	A	O
ATOM	584	N	ILE		89	36.152	88.520	−76.032	1.00	18.04	A	N
ATOM	585	CA	ILE		89	37.079	89.597	−76.411	1.00	18.31	A	C
ATOM	586	CB	ILE		89	36.781	90.867	−75.587	1.00	17.73	A	C
ATOM	587	CG2	ILE		89	37.993	91.797	−75.574	1.00	16.60	A	C
ATOM	588	CG1	ILE		89	35.557	91.613	−76.176	1.00	16.55	A	C
ATOM	589	CD1	ILE		89	35.886	92.467	−77.435	1.00	16.65	A	C
ATOM	590	C	ILE		89	38.534	89.120	−76.164	1.00	19.24	A	C
ATOM	591	O	ILE		89	39.429	89.316	−77.003	1.00	16.39	A	O
ATOM	592	N	ASN		90	38.767	88.547	−74.989	1.00	18.26	A	N
ATOM	593	CA	ASN		90	40.106	88.036	−74.659	1.00	19.40	A	C
ATOM	594	CB	ASN		90	40.133	87.413	−73.260	1.00	20.55	A	C
ATOM	595	CG	ASN		90	40.050	88.444	−72.139	1.00	23.18	A	C
ATOM	596	OD1	ASN		90	40.467	89.606	−72.270	1.00	24.24	A	O
ATOM	597	ND2	ASN		90	39.530	88.004	−71.010	1.00	27.66	A	N
ATOM	598	C	ASN		90	40.566	86.989	−75.672	1.00	18.92	A	C
ATOM	599	O	ASN		90	41.720	87.001	−76.046	1.00	18.63	A	O
ATOM	600	N	GLY		91	39.672	86.090	−76.098	1.00	17.00	A	N
ATOM	601	CA	GLY		91	40.017	85.068	−77.079	1.00	17.60	A	C
ATOM	602	C	GLY		91	40.368	85.689	−78.431	1.00	18.65	A	C
ATOM	603	O	GLY		91	41.306	85.249	−79.134	1.00	17.01	A	O
ATOM	604	N	TYR		92	39.617	86.717	−78.837	1.00	16.91	A	N
ATOM	605	CA	TYR		92	39.907	87.360	−80.110	1.00	15.12	A	C
ATOM	606	CB	TYR		92	38.832	88.425	−80.439	1.00	16.57	A	C
ATOM	607	CG	TYR		92	37.459	87.856	−80.687	1.00	18.85	A	C
ATOM	608	CD1	TYR		92	36.308	88.546	−80.289	1.00	20.18	A	C
ATOM	609	CE1	TYR		92	35.037	88.004	−80.488	1.00	21.76	A	C
ATOM	610	CD2	TYR		92	37.302	86.623	−81.298	1.00	20.52	A	C
ATOM	611	CE2	TYR		92	36.056	86.086	−81.500	1.00	21.54	A	C
ATOM	612	CZ	TYR		92	34.929	86.778	−81.092	1.00	22.64	A	C
ATOM	613	OH	TYR		92	33.701	86.205	−81.281	1.00	21.98	A	O
ATOM	614	C	TYR		92	41.277	88.047	−80.030	1.00	14.32	A	C
ATOM	615	O	TYR		92	42.028	88.036	−80.989	1.00	14.86	A	O
ATOM	616	N	ILE		93	41.581	88.661	−78.893	1.00	13.57	A	N
ATOM	617	CA	ILE		93	42.867	89.344	−78.743	1.00	13.84	A	C
ATOM	618	CB	ILE		93	42.946	90.086	−77.374	1.00	12.27	A	C
ATOM	619	CG2	ILE		93	44.425	90.497	−77.043	1.00	13.10	A	C
ATOM	620	CG1	ILE		93	42.101	91.371	−77.438	1.00	11.51	A	C
ATOM	621	CD1	ILE		93	41.975	92.113	−76.070	1.00	15.66	A	C
ATOM	622	C	ILE		93	43.994	88.313	−78.867	1.00	16.30	A	C
ATOM	623	O	ILE		93	45.030	88.572	−79.513	1.00	13.42	A	O
ATOM	624	N	GLN		94	43.771	87.135	−78.268	1.00	15.22	A	N
ATOM	625	CA	GLN		94	44.777	86.082	−78.323	1.00	18.11	A	C
ATOM	626	CB	GLN		94	44.337	84.847	−77.506	1.00	18.32	A	C
ATOM	627	CG	GLN		94	44.582	85.052	−76.034	1.00	23.10	A	C
ATOM	628	CD	GLN		94	44.162	83.845	−75.186	1.00	31.08	A	C
ATOM	629	OE1	GLN		94	44.740	83.594	−74.134	1.00	35.10	A	O
ATOM	630	NE2	GLN		94	43.160	83.102	−75.645	1.00	30.41	A	N
ATOM	631	C	GLN		94	45.053	85.680	−79.732	1.00	17.69	A	C
ATOM	632	O	GLN		94	46.201	85.571	−80.127	1.00	18.29	A	O
ATOM	633	N	LYS		95	43.996	85.452	−80.500	1.00	17.93	A	N
ATOM	634	CA	LYS		95	44.168	85.052	−81.863	1.00	18.01	A	C
ATOM	635	CB	LYS		95	42.824	84.583	−82.439	1.00	22.92	A	C
ATOM	636	CG	LYS		95	42.403	83.262	−81.850	1.00	29.18	A	C
ATOM	637	CD	LYS		95	41.297	82.644	−82.658	1.00	35.44	A	C
ATOM	638	CE	LYS		95	41.106	81.177	−82.253	1.00	39.10	A	C
ATOM	639	NZ	LYS		95	40.194	80.481	−83.215	1.00	44.13	A	N
ATOM	640	C	LYS		95	44.753	86.125	−82.744	1.00	15.91	A	C
ATOM	641	O	LYS		95	45.429	85.821	−83.728	1.00	18.02	A	O
ATOM	642	N	ILE		96	44.458	87.393	−82.446	1.00	14.05	A	N
ATOM	643	CA	ILE		96	45.013	88.490	−83.244	1.00	14.33	A	C
ATOM	644	CB	ILE		96	44.286	89.846	−82.904	1.00	14.29	A	C
ATOM	645	CG2	ILE		96	45.075	91.034	−83.464	1.00	15.83	A	C
ATOM	646	CG1	ILE		96	42.825	89.797	−83.454	1.00	14.59	A	C
ATOM	647	CD1	ILE		96	41.890	90.934	−82.949	1.00	16.80	A	C
ATOM	648	C	ILE		96	46.511	88.602	−82.931	1.00	14.77	A	C
ATOM	649	O	ILE		96	47.343	88.742	−83.828	1.00	16.25	A	O
ATOM	650	N	LYS		97	46.862	88.538	−81.661	1.00	14.85	A	N
ATOM	651	CA	LYS		97	48.283	88.687	−81.307	1.00	16.64	A	C
ATOM	652	CB	LYS		97	48.450	88.841	−79.781	1.00	15.69	A	C
ATOM	653	CG	LYS		97	48.026	90.219	−79.232	1.00	18.98	A	C
ATOM	654	CD	LYS		97	48.628	90.407	−77.809	1.00	17.75	A	C
ATOM	655	CE	LYS		97	48.518	91.845	−77.332	1.00	20.16	A	C
ATOM	656	NZ	LYS		97	48.987	91.992	−75.918	1.00	19.92	A	N
ATOM	657	C	LYS		97	49.159	87.526	−81.781	1.00	16.39	A	C
ATOM	658	O	LYS		97	50.335	87.723	−82.076	1.00	19.17	A	O
ATOM	659	N	SER		98	48.575	86.344	−81.833	1.00	18.08	A	N
ATOM	660	CA	SER		98	49.287	85.154	−82.287	1.00	18.44	A	C
ATOM	661	CB	SER		98	48.559	83.907	−81.789	1.00	18.84	A	C
ATOM	662	OG	SER		98	47.343	83.703	−82.490	1.00	18.67	A	O
ATOM	663	C	SER		98	49.398	85.126	−83.806	1.00	20.20	A	C
ATOM	664	O	SER		98	50.208	84.383	−84.377	1.00	19.36	A	O
ATOM	665	N	GLY		99	48.613	85.955	−84.487	1.00	19.12	A	N
ATOM	666	CA	GLY		99	48.654	85.930	−85.934	1.00	21.30	A	C
ATOM	667	C	GLY		99	47.751	84.838	−86.510	1.00	22.45	A	C
ATOM	668	O	GLY		99	47.693	84.679	−87.719	1.00	23.65	A	O
ATOM	669	N	GLU		100	47.028	84.120	−85.656	1.00	22.88	A	N
ATOM	670	CA	GLU		100	46.131	83.048	−86.083	1.00	25.56	A	C
ATOM	671	CB	GLU		100	45.623	82.261	−84.859	1.00	27.67	A	C
ATOM	672	CG	GLU		100	46.744	81.404	−84.257	1.00	36.32	A	C
ATOM	673	CD	GLU		100	46.420	80.731	−82.906	1.00	39.72	A	C
ATOM	674	OE1	GLU		100	47.106	79.729	−82.590	1.00	45.08	A	O
ATOM	675	OE2	GLU		100	45.536	81.183	−82.146	1.00	41.22	A	O
ATOM	676	C	GLU		100	44.963	83.591	−86.894	1.00	26.28	A	C
ATOM	677	O	GLU		100	44.494	82.932	−87.812	1.00	24.89	A	O
ATOM	678	N	GLU		101	44.540	84.821	−86.584	1.00	25.76	A	N
ATOM	679	CA	GLU		101	43.444	85.505	−87.266	1.00	27.56	A	C
ATOM	680	CB	GLU		101	42.169	85.341	−86.433	1.00	32.23	A	C
ATOM	681	CG	GLU		101	41.602	83.977	−86.497	1.00	37.74	A	C
ATOM	682	CD	GLU		101	40.675	83.881	−87.668	1.00	40.61	A	C
ATOM	683	OE1	GLU		101	41.053	84.380	−88.751	1.00	43.86	A	O
ATOM	684	OE2	GLU		101	39.575	83.325	−87.501	1.00	42.27	A	O
ATOM	685	C	GLU		101	43.722	87.010	−87.338	1.00	26.45	A	C
ATOM	686	O	GLU		101	44.282	87.552	−86.392	1.00	28.63	A	O
ATOM	687	N	ASP		102	43.373	87.715	−88.410	1.00	23.17	A	N
ATOM	688	CA	ASP		102	43.634	89.132	−88.279	1.00	23.62	A	C
ATOM	689	CB	ASP		102	44.232	89.796	−89.519	1.00	29.72	A	C
ATOM	690	CG	ASP		102	43.482	89.523	−90.763	1.00	31.60	A	C
ATOM	691	OD1	ASP		102	42.233	89.531	−90.699	1.00	34.60	A	O
ATOM	692	OD2	ASP		102	44.164	89.321	−91.820	1.00	33.36	A	O
ATOM	693	C	ASP		102	42.402	89.868	−87.789	1.00	21.92	A	C
ATOM	694	O	ASP		102	41.286	89.352	−87.837	1.00	19.65	A	O
ATOM	695	N	PHE		103	42.649	91.045	−87.258	1.00	19.45	A	N
ATOM	696	CA	PHE		103	41.622	91.899	−86.696	1.00	20.74	A	C
ATOM	697	CB	PHE		103	42.217	93.268	−86.409	1.00	22.01	A	C
ATOM	698	CG	PHE		103	41.280	94.204	−85.727	1.00	24.40	A	C
ATOM	699	CD1	PHE		103	41.300	94.317	−84.344	1.00	24.41	A	C
ATOM	700	CD2	PHE		103	40.316	94.908	−86.458	1.00	27.30	A	C
ATOM	701	CE1	PHE		103	40.365	95.109	−83.699	1.00	28.02	A	C
ATOM	702	CE2	PHE		103	39.365	95.714	−85.809	1.00	25.93	A	C
ATOM	703	CZ	PHE		103	39.397	95.804	−84.438	1.00	27.24	A	C
ATOM	704	C	PHE		103	40.432	92.065	−87.634	1.00	19.25	A	C
ATOM	705	O	PHE		103	39.286	91.884	−87.235	1.00	17.96	A	O
ATOM	706	N	GLU		104	40.730	92.425	−88.875	1.00	19.54	A	N
ATOM	707	CA	GLU		104	39.714	92.678	−89.881	1.00	19.94	A	C
ATOM	708	CB	GLU		104	40.358	93.015	−91.252	1.00	20.36	A	C
ATOM	709	CG	GLU		104	41.122	94.309	−91.247	1.00	21.60	A	C
ATOM	710	CD	GLU		104	42.580	94.139	−90.836	1.00	22.92	A	C
ATOM	711	OE1	GLU		104	42.963	93.137	−90.137	1.00	19.61	A	O
ATOM	712	OE2	GLU		104	43.333	95.046	−91.233	1.00	25.86	A	O
ATOM	713	C	GLU		104	38.768	91.533	−90.089	1.00	20.29	A	C
ATOM	714	O	GLU		104	37.547	91.756	−90.253	1.00	19.85	A	O
ATOM	715	N	SER		105	39.315	90.320	−90.097	1.00	19.38	A	N
ATOM	716	CA	SER		105	38.512	89.129	−90.322	1.00	21.13	A	C
ATOM	717	CB	SER		105	39.442	87.955	−90.610	1.00	23.65	A	C
ATOM	718	OG	SER		105	38.757	86.739	−90.518	1.00	27.30	A	O
ATOM	719	C	SER		105	37.559	88.835	−89.154	1.00	20.00	A	C
ATOM	720	O	SER		105	36.374	88.507	−89.353	1.00	19.10	A	O
ATOM	721	N	LEU		106	38.076	88.951	−87.933	1.00	19.14	A	N
ATOM	722	CA	LEU		106	37.280	88.716	−86.728	1.00	16.75	A	C
ATOM	723	CB	LEU		106	38.196	88.672	−85.496	1.00	16.16	A	C
ATOM	724	CG	LEU		106	39.208	87.493	−85.464	1.00	15.50	A	C
ATOM	725	CD1	LEU		106	40.122	87.595	−84.175	1.00	12.05	A	C
ATOM	726	CD2	LEU		106	38.453	86.179	−85.471	1.00	14.15	A	C
ATOM	727	C	LEU		106	36.250	89.835	−86.577	1.00	15.59	A	C
ATOM	728	O	LEU		106	35.121	89.576	−86.117	1.00	15.74	A	O
ATOM	729	N	ALA		107	36.607	91.065	−86.931	1.00	15.57	A	N
ATOM	730	CA	ALA		107	35.601	92.145	−86.828	1.00	16.29	A	C
ATOM	731	CB	ALA		107	36.199	93.498	−87.126	1.00	16.43	A	C
ATOM	732	C	ALA		107	34.455	91.897	−87.827	1.00	18.03	A	C
ATOM	733	O	ALA		107	33.270	92.080	−87.470	1.00	15.46	A	O
ATOM	734	N	SER		108	34.803	91.489	−89.054	1.00	15.45	A	N
ATOM	735	CA	SER		108	33.783	91.247	−90.078	1.00	18.30	A	C
ATOM	736	CB	SER		108	34.423	90.830	−91.408	1.00	16.85	A	C
ATOM	737	OG	SER		108	35.161	91.927	−91.924	1.00	25.62	A	O
ATOM	738	C	SER		108	32.839	90.123	−89.639	1.00	19.47	A	C
ATOM	739	O	SER		108	31.632	90.162	−89.923	1.00	20.31	A	O
ATOM	740	N	GLN		109	33.392	89.118	−88.976	1.00	18.53	A	N
ATOM	741	CA	GLN		109	32.589	87.992	−88.525	1.00	21.76	A	C
ATOM	742	CB	GLN		109	33.467	86.754	−88.376	1.00	22.14	A	C
ATOM	743	CG	GLN		109	33.979	86.202	−89.702	1.00	26.08	A	C
ATOM	744	CD	GLN		109	35.046	85.135	−89.499	1.00	28.34	A	C
ATOM	745	OE1	GLN		109	36.259	85.392	−89.634	1.00	30.37	A	O
ATOM	746	NE2	GLN		109	34.609	83.948	−89.154	1.00	26.64	A	N
ATOM	747	C	GLN		109	31.856	88.173	−87.204	1.00	21.62	A	C
ATOM	748	O	GLN		109	30.716	87.761	−87.062	1.00	24.00	A	O
ATOM	749	N	PHE		110	32.517	88.804	−86.245	1.00	19.03	A	N
ATOM	750	CA	PHE		110	31.974	88.843	−84.912	1.00	19.99	A	C
ATOM	751	CB	PHE		110	32.915	88.057	−84.013	1.00	18.33	A	C
ATOM	752	CG	PHE		110	33.222	86.698	−84.524	1.00	20.90	A	C
ATOM	753	CD1	PHE		110	34.529	86.356	−84.880	1.00	20.70	A	C
ATOM	754	CD2	PHE		110	32.204	85.764	−84.702	1.00	20.57	A	C
ATOM	755	CE1	PHE		110	34.823	85.090	−85.416	1.00	22.92	A	C
ATOM	756	CE2	PHE		110	32.470	84.492	−85.239	1.00	22.53	A	C
ATOM	757	CZ	PHE		110	33.783	84.147	−85.601	1.00	24.64	A	C
ATOM	758	C	PHE		110	31.628	90.114	−84.205	1.00	19.17	A	C
ATOM	759	O	PHE		110	31.103	90.070	−83.104	1.00	20.19	A	O
ATOM	760	N	SER		111	31.911	91.243	−84.805	1.00	17.72	A	N
ATOM	761	CA	SER		111	31.630	92.484	−84.133	1.00	16.69	A	C
ATOM	762	CB	SER		111	32.268	93.619	−84.866	1.00	15.75	A	C
ATOM	763	OG	SER		111	32.005	94.836	−84.172	1.00	16.48	A	O
ATOM	764	C	SER		111	30.110	92.728	−84.120	1.00	19.02	A	C
ATOM	765	O	SER		111	29.458	92.581	−85.148	1.00	17.71	A	O
ATOM	766	N	ASP		112	29.597	93.155	−82.974	1.00	19.64	A	N
ATOM	767	CA	ASP		112	28.162	93.421	−82.828	1.00	21.94	A	C
ATOM	768	CB	ASP		112	27.710	93.187	−81.382	1.00	20.26	A	C
ATOM	769	CG	ASP		112	27.510	91.727	−81.076	1.00	22.78	A	C
ATOM	770	OD1	ASP		112	26.877	91.038	−81.900	1.00	21.51	A	O
ATOM	771	OD2	ASP		112	27.946	91.265	−79.999	1.00	20.58	A	O
ATOM	772	C	ASP		112	27.819	94.851	−83.228	1.00	23.24	A	C
ATOM	773	O	ASP		112	26.864	95.425	−82.710	1.00	25.37	A	O
ATOM	774	N	CYS		113	28.600	95.442	−84.116	1.00	23.42	A	N
ATOM	775	CA	CYS		113	28.295	96.775	−84.584	1.00	23.67	A	C
ATOM	776	CB	CYS		113	29.417	97.733	−84.188	1.00	21.58	A	C
ATOM	777	SG	CYS		113	29.228	99.432	−84.677	1.00	25.70	A	S
ATOM	778	C	CYS		113	28.180	96.638	−86.102	1.00	23.54	A	C
ATOM	779	O	CYS		113	28.789	95.744	−86.698	1.00	24.58	A	O
ATOM	780	N	SER		114	27.401	97.510	−86.726	1.00	23.60	A	N
ATOM	781	CA	SER		114	27.226	97.459	−88.162	1.00	24.32	A	C
ATOM	782	CB	SER		114	26.129	98.450	−88.603	1.00	27.32	A	C
ATOM	783	OG	SER		114	26.330	99.745	−88.030	1.00	32.64	A	O
ATOM	784	C	SER		114	28.541	97.740	−88.894	1.00	23.82	A	C
ATOM	785	O	SER		114	28.681	97.377	−90.069	1.00	21.84	A	O
ATOM	786	N	SER		115	29.479	98.412	−88.212	1.00	20.29	A	N
ATOM	787	CA	SER		115	30.794	98.686	−88.794	1.00	19.79	A	C
ATOM	788	CB	SER		115	31.661	99.455	−87.798	1.00	18.86	A	C
ATOM	789	OG	SER		115	31.608	98.799	−86.558	1.00	17.56	A	O
ATOM	790	C	SER		115	31.508	97.391	−89.191	1.00	18.21	A	C
ATOM	791	O	SER		115	32.498	97.439	−89.920	1.00	17.69	A	O
ATOM	792	N	ALA		116	31.008	96.247	−88.730	1.00	16.84	A	N
ATOM	793	CA	ALA		116	31.568	94.955	−89.098	1.00	16.89	A	C
ATOM	794	CB	ALA		116	30.697	93.794	−88.535	1.00	18.80	A	C
ATOM	795	C	ALA		116	31.632	94.833	−90.621	1.00	18.74	A	C
ATOM	796	O	ALA		116	32.611	94.278	−91.163	1.00	15.51	A	O
ATOM	797	N	LYS		117	30.617	95.369	−91.316	1.00	16.34	A	N
ATOM	798	CA	LYS		117	30.579	95.234	−92.777	1.00	18.77	A	C
ATOM	799	CB	LYS		117	29.214	95.690	−93.344	1.00	21.57	A	C
ATOM	800	CG	LYS		117	28.049	95.082	−92.672	1.00	26.80	A	C
ATOM	801	CD	LYS		117	28.121	93.599	−92.651	1.00	30.11	A	C
ATOM	802	CE	LYS		117	27.146	93.072	−91.565	1.00	30.28	A	C
ATOM	803	NZ	LYS		117	27.253	91.647	−91.321	1.00	31.77	A	N
ATOM	804	C	LYS		117	31.694	95.990	−93.479	1.00	17.87	A	C
ATOM	805	O	LYS		117	31.909	95.777	−94.670	1.00	18.25	A	O
ATOM	806	N	ALA		118	32.368	96.885	−92.744	1.00	16.99	A	N
ATOM	807	CA	ALA		118	33.514	97.610	−93.252	1.00	19.26	A	C
ATOM	808	CB	ALA		118	33.339	99.151	−93.044	1.00	19.78	A	C
ATOM	809	C	ALA		118	34.797	97.132	−92.545	1.00	18.77	A	C
ATOM	810	O	ALA		118	35.711	97.927	−92.312	1.00	17.15	A	O
ATOM	811	N	ARG		119	34.835	95.851	−92.167	1.00	18.30	A	N
ATOM	812	CA	ARG		119	36.008	95.268	−91.489	1.00	18.69	A	C
ATOM	813	CB	ARG		119	37.255	95.320	−92.430	1.00	20.61	A	C
ATOM	814	CG	ARG		119	37.140	94.365	−93.623	1.00	22.17	A	C
ATOM	815	CD	ARG		119	38.232	94.524	−94.739	1.00	25.75	A	C
ATOM	816	NE	ARG		119	38.514	95.932	−94.967	1.00	29.83	A	N
ATOM	817	CZ	ARG		119	37.707	96.866	−95.509	1.00	32.46	A	C
ATOM	818	NH1	ARG		119	36.458	96.628	−95.967	1.00	27.79	A	N
ATOM	819	NH2	ARG		119	38.156	98.116	−95.532	1.00	34.51	A	N
ATOM	820	C	ARG		119	36.253	96.026	−90.177	1.00	19.31	A	C
ATOM	821	O	ARG		119	37.391	96.132	−89.684	1.00	18.00	A	O
ATOM	822	N	GLY		120	35.161	96.576	−89.630	1.00	16.58	A	N
ATOM	823	CA	GLY		120	35.217	97.301	−88.381	1.00	18.25	A	C
ATOM	824	C	GLY		120	35.681	98.742	−88.422	1.00	16.96	A	C
ATOM	825	O	GLY		120	35.790	99.386	−87.385	1.00	18.18	A	O
ATOM	826	N	ASP		121	35.912	99.269	−89.614	1.00	17.17	A	N
ATOM	827	CA	ASP		121	36.418	100.634	−89.759	1.00	18.90	A	C
ATOM	828	CB	ASP		121	36.880	100.867	−91.216	1.00	19.58	A	C
ATOM	829	CG	ASP		121	37.288	102.320	−91.468	1.00	20.04	A	C
ATOM	830	OD1	ASP		121	38.016	102.878	−90.629	1.00	19.84	A	O
ATOM	831	OD2	ASP		121	36.869	102.906	−92.481	1.00	19.19	A	O
ATOM	832	C	ASP		121	35.365	101.678	−89.377	1.00	20.15	A	C
ATOM	833	O	ASP		121	34.230	101.569	−89.800	1.00	20.34	A	O
ATOM	834	N	LEU		122	35.749	102.645	−88.559	1.00	19.02	A	N
ATOM	835	CA	LEU		122	34.848	103.715	−88.156	1.00	21.65	A	C
ATOM	836	CB	LEU		122	34.921	103.946	−86.652	1.00	20.81	A	C
ATOM	837	CG	LEU		122	34.421	102.760	−85.831	1.00	21.84	A	C
ATOM	838	CD1	LEU		122	34.583	103.084	−84.365	1.00	23.75	A	C
ATOM	839	CD2	LEU		122	32.969	102.456	−86.194	1.00	22.78	A	C
ATOM	840	C	LEU		122	35.173	105.024	−88.851	1.00	23.36	A	C
ATOM	841	O	LEU		122	34.465	105.998	−88.677	1.00	25.30	A	O
ATOM	842	N	GLY		123	36.250	105.067	−89.620	1.00	25.70	A	N
ATOM	843	CA	GLY		123	36.604	106.318	−90.275	1.00	25.24	A	C
ATOM	844	C	GLY		123	37.367	107.190	−89.303	1.00	26.16	A	C
ATOM	845	O	GLY		123	37.671	106.748	−88.174	1.00	25.30	A	O
ATOM	846	N	ALA		124	37.683	108.422	−89.699	1.00	24.36	A	N
ATOM	847	CA	ALA		124	38.452	109.310	−88.816	1.00	26.20	A	C
ATOM	848	CB	ALA		124	39.366	110.207	−89.625	1.00	26.57	A	C
ATOM	849	C	ALA		124	37.531	110.158	−87.941	1.00	27.11	A	C
ATOM	850	O	ALA		124	36.406	110.460	−88.339	1.00	29.63	A	O
ATOM	851	N	PHE		125	37.999	110.522	−86.752	1.00	27.80	A	N
ATOM	852	CA	PHE		125	37.196	111.317	−85.833	1.00	29.24	A	C
ATOM	853	CB	PHE		125	36.278	110.414	−84.988	1.00	29.60	A	C
ATOM	854	CG	PHE		125	37.008	109.286	−84.244	1.00	31.02	A	C
ATOM	855	CD1	PHE		125	37.630	109.520	−83.028	1.00	29.25	A	C
ATOM	856	CD2	PHE		125	37.039	107.993	−84.770	1.00	29.85	A	C
ATOM	857	CE1	PHE		125	38.274	108.470	−82.336	1.00	30.74	A	C
ATOM	858	CE2	PHE		125	37.677	106.940	−84.092	1.00	31.23	A	C
ATOM	859	CZ	PHE		125	38.294	107.175	−82.875	1.00	28.55	A	C
ATOM	860	C	PHE		125	38.066	112.201	−84.968	1.00	30.03	A	C
ATOM	861	O	PHE		125	39.290	111.985	−84.820	1.00	30.86	A	O
ATOM	862	N	SER		126	37.462	113.242	−84.416	1.00	30.81	A	N
ATOM	863	CA	SER		126	38.220	114.160	−83.575	1.00	31.58	A	C
ATOM	864	CB	SER		126	37.942	115.617	−84.009	1.00	33.37	A	C
ATOM	865	OG	SER		126	36.601	115.954	−83.683	1.00	33.92	A	O
ATOM	866	C	SER		126	37.714	113.933	−82.156	1.00	31.65	A	C
ATOM	867	O	SER		126	36.757	113.178	−81.938	1.00	31.14	A	O
ATOM	868	N	ARG		127	38.345	114.570	−81.177	1.00	33.84	A	N
ATOM	869	CA	ARG		127	37.869	114.407	−79.806	1.00	34.42	A	C
ATOM	870	CB	ARG		127	38.834	115.022	−78.791	1.00	34.39	A	C
ATOM	871	CG	ARG		127	39.939	114.099	−78.368	1.00	33.90	A	C
ATOM	872	CD	ARG		127	40.538	114.580	−77.083	1.00	33.65	A	C
ATOM	873	NE	ARG		127	41.728	113.830	−76.709	1.00	33.32	A	N
ATOM	874	CZ	ARG		127	41.734	112.760	−75.920	1.00	31.01	A	C
ATOM	875	NH1	ARG		127	40.594	112.298	−75.419	1.00	29.87	A	N
ATOM	876	NH2	ARG		127	42.899	112.189	−75.597	1.00	28.67	A	N
ATOM	877	C	ARG		127	36.555	115.136	−79.730	1.00	36.57	A	C
ATOM	878	O	ARG		127	36.356	116.139	−80.419	1.00	36.65	A	O
ATOM	879	N	GLY		128	35.645	114.622	−78.924	1.00	37.80	A	N
ATOM	880	CA	GLY		128	34.368	115.282	−78.801	1.00	40.58	A	C
ATOM	881	C	GLY		128	33.303	114.678	−79.688	1.00	41.54	A	C
ATOM	882	O	GLY		128	32.308	115.349	−79.945	1.00	42.23	A	O
ATOM	883	N	GLN		129	33.501	113.436	−80.153	1.00	41.18	A	N
ATOM	884	CA	GLN		129	32.525	112.765	−81.012	1.00	39.94	A	C
ATOM	885	CB	GLN		129	33.046	112.586	−82.444	1.00	39.92	A	C
ATOM	886	CG	GLN		129	33.650	113.809	−83.112	1.00	41.65	A	C
ATOM	887	CD	GLN		129	33.975	113.553	−84.589	1.00	42.62	A	C
ATOM	888	OE1	GLN		129	34.806	114.236	−85.192	1.00	43.40	A	O
ATOM	889	NE2	GLN		129	33.306	112.570	−85.173	1.00	43.98	A	N
ATOM	890	C	GLN		129	32.088	111.390	−80.514	1.00	40.33	A	C
ATOM	891	O	GLN		129	30.917	111.067	−80.629	1.00	40.78	A	O
ATOM	892	N	MET		130	33.009	110.574	−79.976	1.00	39.29	A	N
ATOM	893	CA	MET		130	32.678	109.206	−79.509	1.00	37.91	A	C
ATOM	894	CB	MET		130	33.834	108.248	−79.869	1.00	38.70	A	C
ATOM	895	CG	MET		130	34.429	108.416	−81.257	1.00	38.21	A	C
ATOM	896	SD	MET		130	33.246	107.975	−82.546	1.00	40.84	A	S
ATOM	897	CE	MET		130	33.076	106.352	−82.287	1.00	40.34	A	C
ATOM	898	C	MET		130	32.423	109.043	−77.989	1.00	37.09	A	C
ATOM	899	O	MET		130	32.668	109.959	−77.225	1.00	37.50	A	O
ATOM	900	N	GLN		131	31.936	107.879	−77.564	1.00	36.12	A	N
ATOM	901	CA	GLN		131	31.767	107.617	−76.132	1.00	37.22	A	C
ATOM	902	CB	GLN		131	31.288	106.186	−75.890	1.00	39.10	A	C
ATOM	903	CG	GLN		131	29.774	106.026	−76.033	1.00	42.50	A	C
ATOM	904	CD	GLN		131	29.310	104.582	−75.864	1.00	44.70	A	C
ATOM	905	OE1	GLN		131	28.140	104.315	−75.580	1.00	47.49	A	O
ATOM	906	NE2	GLN		131	30.217	103.649	−76.058	1.00	45.09	A	N
ATOM	907	C	GLN		131	33.167	107.847	−75.519	1.00	36.77	A	C
ATOM	908	O	GLN		131	34.203	107.388	−76.047	1.00	34.55	A	O
ATOM	909	N	LYS		132	33.196	108.594	−74.423	1.00	34.30	A	N
ATOM	910	CA	LYS		132	34.451	108.976	−73.779	1.00	32.67	A	C
ATOM	911	CB	LYS		132	34.124	109.644	−72.433	1.00	33.55	A	C
ATOM	912	CG	LYS		132	35.288	110.388	−71.820	1.00	33.86	A	C
ATOM	913	CD	LYS		132	35.846	111.451	−72.744	1.00	33.85	A	C
ATOM	914	CE	LYS		132	37.141	111.988	−72.157	1.00	36.22	A	C
ATOM	915	NZ	LYS		132	37.949	112.835	−73.056	1.00	36.55	A	N
ATOM	916	C	LYS		132	35.552	107.895	−73.610	1.00	29.94	A	C
ATOM	917	O	LYS		132	36.725	108.138	−73.933	1.00	30.20	A	O
ATOM	918	N	PRO		133	35.203	106.716	−73.088	1.00	27.61	A	N
ATOM	919	CD	PRO		133	33.911	106.214	−72.604	1.00	28.84	A	C
ATOM	920	CA	PRO		133	36.254	105.704	−72.933	1.00	27.73	A	C
ATOM	921	CB	PRO		133	35.531	104.540	−72.258	1.00	27.32	A	C
ATOM	922	CG	PRO		133	34.333	105.190	−71.590	1.00	29.00	A	C
ATOM	923	C	PRO		133	36.848	105.269	−74.283	1.00	26.85	A	C
ATOM	924	O	PRO		133	38.056	104.996	−74.381	1.00	26.46	A	O
ATOM	925	N	PHE		134	35.992	105.207	−75.312	1.00	25.47	A	N
ATOM	926	CA	PHE		134	36.424	104.790	−76.646	1.00	23.15	A	C
ATOM	927	CB	PHE		134	35.209	104.652	−77.573	1.00	20.08	A	C
ATOM	928	CG	PHE		134	35.530	104.023	−78.909	1.00	19.50	A	C
ATOM	929	CD1	PHE		134	35.399	102.656	−79.096	1.00	17.39	A	C
ATOM	930	CD2	PHE		134	36.015	104.790	−79.951	1.00	19.22	A	C
ATOM	931	CE1	PHE		134	35.761	102.059	−80.323	1.00	20.05	A	C
ATOM	932	CE2	PHE		134	36.382	104.189	−81.169	1.00	19.39	A	C
ATOM	933	CZ	PHE		134	36.248	102.830	−81.330	1.00	17.27	A	C
ATOM	934	C	PHE		134	37.341	105.882	−77.145	1.00	21.95	A	C
ATOM	935	O	PHE		134	38.435	105.635	−77.674	1.00	19.32	A	O
ATOM	936	N	GLU		135	36.902	107.130	−76.955	1.00	20.33	A	N
ATOM	937	CA	GLU		135	37.700	108.246	−77.400	1.00	20.23	A	C
ATOM	938	CB	GLU		135	37.009	109.590	−77.086	1.00	20.40	A	C
ATOM	939	CG	GLU		135	37.953	110.752	−77.201	1.00	24.60	A	C
ATOM	940	CD	GLU		135	37.251	112.098	−76.882	1.00	29.23	A	C
ATOM	941	OE1	GLU		135	36.086	112.269	−77.330	1.00	26.62	A	O
ATOM	942	OE2	GLU		135	37.881	112.938	−76.198	1.00	30.65	A	O
ATOM	943	C	GLU		135	39.080	108.256	−76.779	1.00	20.28	A	C
ATOM	944	O	GLU		135	40.110	108.312	−77.490	1.00	19.35	A	O
ATOM	945	N	ASP		136	39.115	108.233	−75.449	1.00	18.56	A	N
ATOM	946	CA	ASP		136	40.397	108.265	−74.751	1.00	19.44	A	C
ATOM	947	CB	ASP		136	40.179	108.205	−73.248	1.00	20.59	A	C
ATOM	948	CG	ASP		136	39.663	109.537	−72.690	1.00	23.97	A	C
ATOM	949	OD1	ASP		136	39.779	110.573	−73.391	1.00	22.30	A	O
ATOM	950	OD2	ASP		136	39.174	109.529	−71.548	1.00	25.27	A	O
ATOM	951	C	ASP		136	41.350	107.140	−75.155	1.00	16.85	A	C
ATOM	952	O	ASP		136	42.557	107.350	−75.323	1.00	18.14	A	O
ATOM	953	N	ALA		137	40.805	105.953	−75.287	1.00	18.11	A	N
ATOM	954	CA	ALA		137	41.623	104.779	−75.674	1.00	16.81	A	C
ATOM	955	CB	ALA		137	40.733	103.530	−75.632	1.00	15.80	A	C
ATOM	956	C	ALA		137	42.149	105.033	−77.113	1.00	16.85	A	C
ATOM	957	O	ALA		137	43.347	104.878	−77.425	1.00	16.40	A	O
ATOM	958	N	SER		138	41.258	105.486	−77.990	1.00	17.57	A	N
ATOM	959	CA	SER		138	41.659	105.747	−79.369	1.00	18.64	A	C
ATOM	960	CB	SER		138	40.454	106.184	−80.232	1.00	18.01	A	C
ATOM	961	OG	SER		138	39.505	105.151	−80.304	1.00	18.74	A	O
ATOM	962	C	SER		138	42.770	106.745	−79.506	1.00	20.78	A	C
ATOM	963	O	SER		138	43.702	106.508	−80.264	1.00	20.45	A	O
ATOM	964	N	PHE		139	42.718	107.848	−78.756	1.00	20.81	A	N
ATOM	965	CA	PHE		139	43.741	108.870	−78.867	1.00	22.12	A	C
ATOM	966	CB	PHE		139	43.213	110.254	−78.378	1.00	22.25	A	C
ATOM	967	CG	PHE		139	42.444	110.995	−79.447	1.00	23.41	A	C
ATOM	968	CD1	PHE		139	41.127	110.697	−79.694	1.00	23.40	A	C
ATOM	969	CD2	PHE		139	43.100	111.884	−80.286	1.00	24.82	A	C
ATOM	970	CE1	PHE		139	40.453	111.272	−80.796	1.00	26.94	A	C
ATOM	971	CE2	PHE		139	42.465	112.453	−81.360	1.00	26.50	A	C
ATOM	972	CZ	PHE		139	41.129	112.149	−81.626	1.00	25.32	A	C
ATOM	973	C	PHE		139	45.021	108.521	−78.143	1.00	22.42	A	C
ATOM	974	O	PHE		139	46.051	109.131	−78.411	1.00	24.68	A	O
ATOM	975	N	ALA		140	44.951	107.538	−77.248	1.00	21.64	A	N
ATOM	976	CA	ALA		140	46.121	107.104	−76.485	1.00	21.40	A	C
ATOM	977	CB	ALA		140	45.680	106.569	−75.112	1.00	19.38	A	C
ATOM	978	C	ALA		140	46.923	106.040	−77.253	1.00	21.95	A	C
ATOM	979	O	ALA		140	48.091	105.797	−76.936	1.00	21.81	A	O
ATOM	980	N	LEU		141	46.307	105.427	−78.270	1.00	21.31	A	N
ATOM	981	CA	LEU		141	46.998	104.437	−79.105	1.00	23.06	A	C
ATOM	982	CB	LEU		141	45.983	103.609	−79.923	1.00	20.42	A	C
ATOM	983	CG	LEU		141	45.091	102.621	−79.157	1.00	19.85	A	C
ATOM	984	CD1	LEU		141	43.983	102.129	−80.109	1.00	16.71	A	C
ATOM	985	CD2	LEU		141	45.898	101.454	−78.615	1.00	19.89	A	C
ATOM	986	C	LEU		141	47.878	105.160	−80.101	1.00	24.61	A	C
ATOM	987	O	LEU		141	47.560	106.279	−80.496	1.00	24.42	A	O
ATOM	988	N	ARG		142	48.979	104.526	−80.505	1.00	26.12	A	N
ATOM	989	CA	ARG		142	49.851	105.066	−81.531	1.00	26.46	A	C
ATOM	990	CB	ARG		142	51.294	104.643	−81.285	1.00	29.86	A	C
ATOM	991	CG	ARG		142	51.749	104.853	−79.849	1.00	33.68	A	C
ATOM	992	CD	ARG		142	53.175	104.476	−79.736	1.00	37.87	A	C
ATOM	993	NE	ARG		142	53.471	103.906	−78.437	1.00	40.98	A	N
ATOM	994	CZ	ARG		142	53.194	102.658	−78.082	1.00	43.11	A	C
ATOM	995	NH1	ARG		142	52.603	101.798	−78.935	1.00	43.53	A	N
ATOM	996	NH2	ARG		142	53.499	102.273	−76.852	1.00	44.47	A	N
ATOM	997	C	ARG		142	49.340	104.404	−82.810	1.00	26.06	A	C
ATOM	998	O	ARG		142	48.681	103.372	−82.756	1.00	22.42	A	O
ATOM	999	N	THR		143	49.634	104.993	−83.953	1.00	24.61	A	N
ATOM	1000	CA	THR		143	49.194	104.415	−85.202	1.00	26.62	A	C
ATOM	1001	CB	THR		143	49.725	105.219	−86.374	1.00	28.69	A	C
ATOM	1002	OG1	THR		143	49.096	106.494	−86.339	1.00	33.62	A	O
ATOM	1003	CG2	THR		143	49.385	104.551	−87.702	1.00	29.97	A	C
ATOM	1004	C	THR		143	49.702	102.993	−85.310	1.00	26.07	A	C
ATOM	1005	O	THR		143	50.898	102.738	−85.100	1.00	23.72	A	O
ATOM	1006	N	GLY		144	48.788	102.071	−85.605	1.00	22.98	A	N
ATOM	1007	CA	GLY		144	49.170	100.678	−85.735	1.00	22.71	A	C
ATOM	1008	C	GLY		144	48.924	99.849	−84.485	1.00	20.73	A	C
ATOM	1009	O	GLY		144	48.859	98.612	−84.549	1.00	20.00	A	O
ATOM	1010	N	GLU		145	48.771	100.525	−83.343	1.00	19.85	A	N
ATOM	1011	CA	GLU		145	48.562	99.829	−82.079	1.00	19.58	A	C
ATOM	1012	CB	GLU		145	49.116	100.678	−80.947	1.00	20.15	A	C
ATOM	1013	CG	GLU		145	49.025	100.035	−79.590	1.00	26.73	A	C
ATOM	1014	CD	GLU		145	49.534	100.956	−78.485	1.00	30.45	A	C
ATOM	1015	OE1	GLU		145	49.784	102.182	−78.774	1.00	30.77	A	O
ATOM	1016	OE2	GLU		145	49.668	100.441	−77.345	1.00	30.02	A	O
ATOM	1017	C	GLU		145	47.114	99.426	−81.812	1.00	19.24	A	C
ATOM	1018	O	GLU		145	46.163	100.068	−82.295	1.00	19.29	A	O
ATOM	1019	N	MET		146	46.960	98.336	−81.086	1.00	15.79	A	N
ATOM	1020	CA	MET		146	45.655	97.778	−80.721	1.00	15.54	A	C
ATOM	1021	CB	MET		146	45.555	96.301	−81.140	1.00	15.92	A	C
ATOM	1022	CG	MET		146	44.195	95.641	−80.857	1.00	17.65	A	C
ATOM	1023	SD	MET		146	44.192	93.964	−81.526	1.00	18.77	A	S
ATOM	1024	CE	MET		146	45.080	93.104	−80.239	1.00	19.12	A	C
ATOM	1025	C	MET		146	45.457	97.866	−79.203	1.00	14.04	A	C
ATOM	1026	O	MET		146	46.390	97.687	−78.402	1.00	13.72	A	O
ATOM	1027	N	SER		147	44.225	98.110	−78.805	1.00	11.92	A	N
ATOM	1028	CA	SER		147	43.921	98.204	−77.386	1.00	12.79	A	C
ATOM	1029	CB	SER		147	42.628	99.018	−77.196	1.00	12.46	A	C
ATOM	1030	OG	SER		147	41.475	98.257	−77.621	1.00	13.56	A	O
ATOM	1031	C	SER		147	43.669	96.841	−76.784	1.00	12.38	A	C
ATOM	1032	O	SER		147	43.648	95.839	−77.480	1.00	14.87	A	O
ATOM	1033	N	GLY		148	43.495	96.846	−75.473	1.00	14.75	A	N
ATOM	1034	CA	GLY		148	43.033	95.663	−74.764	1.00	15.86	A	C
ATOM	1035	C	GLY		148	41.500	95.883	−74.694	1.00	16.87	A	C
ATOM	1036	O	GLY		148	40.940	96.703	−75.437	1.00	16.19	A	O
ATOM	1037	N	PRO		149	40.800	95.183	−73.811	1.00	18.59	A	N
ATOM	1038	CD	PRO		149	41.311	94.147	−72.911	1.00	17.63	A	C
ATOM	1039	CA	PRO		149	39.333	95.339	−73.696	1.00	19.64	A	C
ATOM	1040	CB	PRO		149	38.944	94.251	−72.690	1.00	19.84	A	C
ATOM	1041	CG	PRO		149	40.092	93.220	−72.808	1.00	20.94	A	C
ATOM	1042	C	PRO		149	39.027	96.758	−73.205	1.00	18.98	A	C
ATOM	1043	O	PRO		149	39.612	97.208	−72.219	1.00	18.83	A	O
ATOM	1044	N	VAL		150	38.137	97.454	−73.908	1.00	17.89	A	N
ATOM	1045	CA	VAL		150	37.753	98.824	−73.549	1.00	17.17	A	C
ATOM	1046	CB	VAL		150	38.097	99.803	−74.667	1.00	16.06	A	C
ATOM	1047	CG1	VAL		150	37.486	101.213	−74.404	1.00	16.58	A	C
ATOM	1048	CG2	VAL		150	39.614	99.917	−74.795	1.00	18.32	A	C
ATOM	1049	C	VAL		150	36.250	98.758	−73.293	1.00	19.14	A	C
ATOM	1050	O	VAL		150	35.479	98.405	−74.176	1.00	18.06	A	O
ATOM	1051	N	PHE		151	35.854	99.078	−72.067	1.00	19.43	A	N
ATOM	1052	CA	PHE		151	34.460	98.995	−71.687	1.00	21.52	A	C
ATOM	1053	CB	PHE		151	34.378	98.671	−70.209	1.00	20.18	A	C
ATOM	1054	CG	PHE		151	34.947	97.339	−69.859	1.00	23.04	A	C
ATOM	1055	CD1	PHE		151	36.328	97.171	−69.706	1.00	22.27	A	C
ATOM	1056	CD2	PHE		151	34.126	96.250	−69.715	1.00	21.27	A	C
ATOM	1057	CE1	PHE		151	36.845	95.937	−69.417	1.00	23.27	A	C
ATOM	1058	CE2	PHE		151	34.649	95.000	−69.420	1.00	22.33	A	C
ATOM	1059	CZ	PHE		151	36.003	94.840	−69.272	1.00	23.79	A	C
ATOM	1060	C	PHE		151	33.704	100.291	−71.965	1.00	21.36	A	C
ATOM	1061	O	PHE		151	34.202	101.382	−71.680	1.00	21.59	A	O
ATOM	1062	N	THR		152	32.524	100.172	−72.556	1.00	22.60	A	N
ATOM	1063	CA	THR		152	31.688	101.344	−72.812	1.00	23.33	A	C
ATOM	1064	CB	THR		152	31.777	101.878	−74.285	1.00	24.44	A	C
ATOM	1065	OG1	THR		152	31.179	100.904	−75.139	1.00	23.16	A	O
ATOM	1066	CG2	THR		152	33.247	102.161	−74.721	1.00	24.50	A	C
ATOM	1067	C	THR		152	30.247	100.893	−72.594	1.00	22.81	A	C
ATOM	1068	O	THR		152	29.958	99.689	−72.480	1.00	20.21	A	O
ATOM	1069	N	ASP		153	29.337	101.865	−72.545	1.00	25.30	A	N
ATOM	1070	CA	ASP		153	27.928	101.537	−72.366	1.00	28.11	A	C
ATOM	1071	CB	ASP		153	27.101	102.814	−72.357	1.00	31.85	A	C
ATOM	1072	CG	ASP		153	26.841	103.311	−70.969	1.00	37.63	A	C
ATOM	1073	OD1	ASP		153	27.756	103.219	−70.108	1.00	39.38	A	O
ATOM	1074	OD2	ASP		153	25.707	103.808	−70.749	1.00	41.99	A	O
ATOM	1075	C	ASP		153	27.403	100.627	−73.454	1.00	28.36	A	C
ATOM	1076	O	ASP		153	26.428	99.888	−73.237	1.00	29.95	A	O
ATOM	1077	N	SER		154	28.019	100.665	−74.643	1.00	27.09	A	N
ATOM	1078	CA	SER		154	27.501	99.826	−75.706	1.00	25.64	A	C
ATOM	1079	CB	SER		154	27.748	100.487	−77.077	1.00	27.69	A	C
ATOM	1080	OG	SER		154	29.132	100.540	−77.395	1.00	32.52	A	O
ATOM	1081	C	SER		154	28.027	98.390	−75.655	1.00	24.75	A	C
ATOM	1082	O	SER		154	27.415	97.465	−76.226	1.00	22.83	A	O
ATOM	1083	N	GLY		155	29.114	98.181	−74.906	1.00	21.12	A	N
ATOM	1084	CA	GLY		155	29.662	96.836	−74.821	1.00	20.72	A	C
ATOM	1085	C	GLY		155	31.181	96.911	−74.659	1.00	18.96	A	C
ATOM	1086	O	GLY		155	31.702	97.956	−74.291	1.00	18.55	A	O
ATOM	1087	N	ILE		156	31.880	95.813	−74.945	1.00	17.66	A	N
ATOM	1088	CA	ILE		156	33.344	95.784	−74.793	1.00	17.00	A	C
ATOM	1089	CB	ILE		156	33.808	94.483	−74.082	1.00	17.02	A	C
ATOM	1090	CG2	ILE		156	35.368	94.514	−73.853	1.00	19.62	A	C
ATOM	1091	CG1	ILE		156	33.038	94.296	−72.742	1.00	19.91	A	C
ATOM	1092	CD1	ILE		156	33.285	92.909	−72.055	1.00	20.07	A	C
ATOM	1093	C	ILE		156	33.972	95.810	−76.189	1.00	16.59	A	C
ATOM	1094	O	ILE		156	33.611	95.014	−77.051	1.00	17.11	A	O
ATOM	1095	N	HIS		157	34.944	96.690	−76.394	1.00	18.12	A	N
ATOM	1096	CA	HIS		157	35.593	96.802	−77.690	1.00	16.12	A	C
ATOM	1097	CB	HIS		157	35.611	98.269	−78.138	1.00	17.10	A	C
ATOM	1098	CG	HIS		157	34.284	98.978	−78.109	1.00	18.76	A	C
ATOM	1099	CD2	HIS		157	33.538	99.449	−77.071	1.00	18.91	A	C
ATOM	1100	ND1	HIS		157	33.706	99.483	−79.253	1.00	17.73	A	N
ATOM	1101	CE1	HIS		157	32.674	100.255	−78.921	1.00	20.15	A	C
ATOM	1102	NE2	HIS		157	32.551	100.249	−77.605	1.00	17.69	A	N
ATOM	1103	C	HIS		157	37.097	96.398	−77.682	1.00	17.40	A	C
ATOM	1104	O	HIS		157	37.754	96.413	−76.635	1.00	17.71	A	O
ATOM	1105	N	ILE		158	37.599	96.065	−78.870	1.00	15.28	A	N
ATOM	1106	CA	ILE		158	39.031	95.910	−79.112	1.00	16.21	A	C
ATOM	1107	CB	ILE		158	39.414	94.580	−79.766	1.00	16.97	A	C
ATOM	1108	CG2	ILE		158	40.942	94.616	−80.060	1.00	19.87	A	C
ATOM	1109	CG1	ILE		158	39.150	93.428	−78.801	1.00	18.11	A	C
ATOM	1110	CD1	ILE		158	39.204	92.071	−79.492	1.00	18.15	A	C
ATOM	1111	C	ILE		158	39.143	97.044	−80.169	1.00	16.56	A	C
ATOM	1112	O	ILE		158	38.345	97.080	−81.110	1.00	17.25	A	O
ATOM	1113	N	ILE		159	40.074	97.979	−79.999	1.00	15.75	A	N
ATOM	1114	CA	ILE		159	40.190	99.109	−80.916	1.00	15.79	A	C
ATOM	1115	CB	ILE		159	40.069	100.469	−80.161	1.00	15.18	A	C
ATOM	1116	CG2	ILE		159	40.215	101.640	−81.108	1.00	14.17	A	C
ATOM	1117	CG1	ILE		159	38.756	100.522	−79.417	1.00	18.67	A	C
ATOM	1118	CD1	ILE		159	38.670	101.700	−78.379	1.00	16.07	A	C
ATOM	1119	C	ILE		159	41.545	99.052	−81.616	1.00	16.35	A	C
ATOM	1120	O	ILE		159	42.551	98.754	−80.991	1.00	17.23	A	O
ATOM	1121	N	LEU		160	41.550	99.299	−82.925	1.00	14.90	A	N
ATOM	1122	CA	LEU		160	42.804	99.294	−83.681	1.00	15.91	A	C
ATOM	1123	CB	LEU		160	42.784	98.243	−84.806	1.00	14.83	A	C
ATOM	1124	CG	LEU		160	44.001	98.257	−85.755	1.00	17.97	A	C
ATOM	1125	CD1	LEU		160	45.243	97.720	−85.026	1.00	16.47	A	C
ATOM	1126	CD2	LEU		160	43.756	97.401	−86.975	1.00	19.42	A	C
ATOM	1127	C	LEU		160	42.961	100.683	−84.303	1.00	15.46	A	C
ATOM	1128	O	LEU		160	42.118	101.120	−85.062	1.00	17.21	A	O
ATOM	1129	N	ARG		161	44.020	101.373	−83.953	1.00	17.32	A	N
ATOM	1130	CA	ARG		161	44.227	102.692	−84.540	1.00	18.67	A	C
ATOM	1131	CB	ARG		161	45.013	103.612	−83.603	1.00	18.01	A	C
ATOM	1132	CG	ARG		161	45.354	104.930	−84.330	1.00	21.10	A	C
ATOM	1133	CD	ARG		161	46.032	105.994	−83.431	1.00	24.02	A	C
ATOM	1134	NE	ARG		161	46.346	107.148	−84.271	1.00	26.05	A	N
ATOM	1135	CZ	ARG		161	47.196	108.115	−83.934	1.00	28.94	A	C
ATOM	1136	NH1	ARG		161	47.809	108.079	−82.747	1.00	29.33	A	N
ATOM	1137	NH2	ARG		161	47.482	109.085	−84.808	1.00	27.52	A	N
ATOM	1138	C	ARG		161	44.952	102.491	−85.879	1.00	18.85	A	C
ATOM	1139	O	ARG		161	46.046	101.916	−85.936	1.00	19.13	A	O
ATOM	1140	N	THR		162	44.307	102.924	−86.952	1.00	19.16	A	N
ATOM	1141	CA	THR		162	44.877	102.761	−88.286	1.00	21.01	A	C
ATOM	1142	CB	THR		162	43.807	102.302	−89.256	1.00	20.38	A	C
ATOM	1143	OG1	THR		162	42.725	103.237	−89.245	1.00	21.90	A	O
ATOM	1144	CG2	THR		162	43.302	100.884	−88.851	1.00	19.88	A	C
ATOM	1145	C	THR		162	45.522	104.046	−88.837	1.00	23.01	A	C
ATOM	1146	O	THR		162	46.309	103.965	−89.766	1.00	22.61	A	O
ATOM	1147	N	GLU		163	45.167	105.206	−88.278	1.00	23.69	A	N
ATOM	1148	CA	GLU		163	45.744	106.497	−88.709	1.00	26.00	A	C
ATOM	1149	CB	GLU		163	44.930	107.128	−89.860	1.00	27.09	A	C
ATOM	1150	CG	GLU		163	44.841	106.304	−91.128	1.00	28.74	A	C
ATOM	1151	CD	GLU		163	44.005	106.980	−92.214	1.00	31.06	A	C
ATOM	1152	OE1	GLU		163	43.536	108.124	−91.994	1.00	33.77	A	O
ATOM	1153	OE2	GLU		163	43.814	106.364	−93.282	1.00	34.04	A	O
ATOM	1154	C	GLU		163	45.721	107.480	−87.555	1.00	26.50	A	C
ATOM	1155	O	GLU		163	44.872	107.275	−86.663	1.00	25.73	A	O
ATOM	1156	OXT	GLU		163	46.510	108.472	−87.579	1.00	27.66	A	O
TER	1157		GLU		163						A
ATOM	1158	OH2	TIP	S	1	48.082	101.427	−75.587	1.00	18.04		O
ATOM	1159	OH2	TIP	S	2	51.585	89.916	−81.211	1.00	21.10		O
ATOM	1160	OH2	TIP	S	3	51.859	92.089	−76.864	1.00	21.56		O
ATOM	1161	OH2	TIP	S	4	33.038	96.453	−85.963	1.00	17.76		O
ATOM	1162	OH2	TIP	S	5	49.809	103.573	−76.650	1.00	19.97		O
ATOM	1163	OH2	TIP	S	6	42.201	100.433	−67.302	1.00	19.76		O
ATOM	1164	OH2	TIP	S	7	29.972	91.630	−91.548	1.00	21.62		O
ATOM	1165	OH2	TIP	S	8	40.318	101.816	−89.576	1.00	19.74		O
ATOM	1166	OH2	TIP	S	9	26.286	88.424	−80.928	1.00	25.66		O
ATOM	1167	OH2	TIP	S	10	39.431	97.561	−90.394	1.00	22.73		O
ATOM	1168	OH2	TIP	S	11	47.173	89.684	−86.326	1.00	16.74		O
ATOM	1169	OH2	TIP	S	12	37.748	100.288	−70.225	1.00	20.44		O
ATOM	1170	OH2	TIP	S	13	35.319	94.118	−96.397	1.00	28.89		O
ATOM	1171	OH2	TIP	S	14	45.823	93.900	−70.890	1.00	32.12		O
ATOM	1172	OH2	TIP	S	15	24.392	86.549	−76.670	1.00	36.77		O
ATOM	1173	OH2	TIP	S	16	36.930	84.348	−78.407	1.00	24.07		O
ATOM	1174	OH2	TIP	S	17	30.444	104.610	−72.507	1.00	33.01		O
ATOM	1175	OH2	TIP	S	18	35.656	111.545	−79.929	1.00	34.16		O
ATOM	1176	OH2	TIP	S	19	49.491	90.772	−71.572	1.00	22.03		O
ATOM	1177	OH2	TIP	S	20	33.500	83.562	−81.832	1.00	31.26		O
ATOM	1178	OH2	TIP	S	21	33.951	93.386	−93.865	1.00	22.89		O
ATOM	1179	OH2	TIP	S	22	29.775	89.263	−80.786	1.00	22.40		O
ATOM	1180	OH2	TIP	S	23	31.250	87.067	−80.332	1.00	29.99		O
ATOM	1181	OH2	TIP	S	24	14.398	93.475	−82.021	1.00	50.82		O
ATOM	1182	OH2	TIP	S	25	43.747	88.370	−74.291	1.00	23.50		O
ATOM	1183	OH2	TIP	S	26	42.882	90.738	−73.315	1.00	31.29		O
ATOM	1184	OH2	TIP	S	27	32.177	83.374	−88.949	1.00	36.46		O
ATOM	1185	OH2	TIP	S	28	37.581	91.106	−93.529	1.00	49.86		O
ATOM	1186	OH2	TIP	S	29	30.669	97.024	−71.398	1.00	31.36		O
ATOM	1187	OH2	TIP	S	30	39.488	106.765	−70.207	1.00	42.47		O
ATOM	1188	OH2	TIP	S	31	59.907	93.177	−70.669	1.00	25.62		O
ATOM	1189	OH2	TIP	S	32	27.485	86.442	−87.274	1.00	35.47		O
ATOM	1190	OH2	TIP	S	33	43.516	109.696	−74.501	1.00	27.08		O
ATOM	1191	OH2	TIP	S	34	40.284	115.890	−81.404	1.00	41.78		O
ATOM	1192	OH2	TIP	S	35	62.200	97.097	−70.936	1.00	44.03		O
ATOM	1193	OH2	TIP	S	36	50.803	88.917	−64.686	1.00	32.48		O
ATOM	1194	OH2	TIP	S	37	25.215	98.897	−85.264	1.00	34.24		O
ATOM	1195	OH2	TIP	S	38	48.708	102.884	−61.798	1.00	33.13		O
ATOM	1196	OH2	TIP	S	39	35.694	102.146	−94.826	1.00	35.27		O
ATOM	1197	OH2	TIP	S	40	17.845	86.830	−80.637	1.00	37.49		O
ATOM	1198	OH2	TIP	S	41	24.535	91.152	−92.236	1.00	27.61		O
ATOM	1199	OH2	TIP	S	42	46.829	99.932	−88.480	1.00	45.14		O
ATOM	1200	OH2	TIP	S	43	62.395	91.861	−66.549	1.00	45.59		O
ATOM	1201	OH2	TIP	S	44	60.573	90.712	−72.271	1.00	31.99		O
ATOM	1202	OH2	TIP	S	45	40.578	95.056	−70.054	1.00	46.81		O
ATOM	1203	OH2	TIP	S	46	49.074	95.085	−64.867	1.00	35.64		O
ATOM	1204	OH2	TIP	S	47	40.835	96.865	−94.234	1.00	44.13		O
ATOM	1205	OH2	TIP	S	48	24.594	99.044	−77.314	1.00	41.88		O
ATOM	1206	OH2	TIP	S	49	41.930	97.181	−91.862	1.00	50.35		O
ATOM	1207	OH2	TIP	S	50	60.648	82.708	−64.686	1.00	47.29		O
ATOM	1208	OH2	TIP	S	51	32.360	83.711	−73.398	1.00	38.49		O
ATOM	1209	OH2	TIP	S	52	48.777	108.478	−79.503	1.00	42.78		O
ATOM	1210	OH2	TIP	S	53	49.840	106.726	−75.333	1.00	35.93		O
ATOM	1211	OH2	TIP	S	54	38.881	83.687	−73.492	1.00	32.30		O
ATOM	1212	OH2	TIP	S	55	45.653	110.825	−87.456	1.00	41.44		O
ATOM	1213	OH2	TIP	S	56	24.533	95.593	−85.731	1.00	34.34		O
ATOM	1214	OH2	TIP	S	57	20.711	91.253	−89.187	1.00	38.38		O
ATOM	1215	OH2	TIP	S	58	54.487	91.949	−76.096	1.00	24.32		O
ATOM	1216	OH2	TIP	S	59	56.957	85.342	−72.648	1.00	24.26		O
ATOM	1217	OH2	TIP	S	60	48.492	96.151	−83.544	1.00	28.10		O
ATOM	1218	OH2	TIP	S	61	49.378	97.039	−80.336	1.00	30.72		O
ATOM	1219	OH2	TIP	S	62	50.809	97.992	−77.160	1.00	36.73		O
ATOM	1220	OH2	TIP	S	63	39.546	104.486	−72.141	1.00	26.60		O
ATOM	1221	OH2	TIP	S	64	41.331	101.384	−92.014	1.00	31.75		O
ATOM	1222	OH2	TIP	S	65	54.905	96.001	−78.802	1.00	49.60		O
ATOM	1223	OH2	TIP	S	66	42.906	110.367	−71.323	1.00	37.82		O
ATOM	1224	OH2	TIP	S	67	38.157	101.156	−96.112	1.00	41.06		O
ATOM	1225	OH2	TIP	S	68	50.686	92.674	−82.160	1.00	38.59		O
ATOM	1226	OH2	TIP	S	69	40.110	90.150	−93.660	1.00	47.25		O
ATOM	1227	OH2	TIP	S	70	51.482	87.184	−71.081	1.00	37.17		O
ATOM	1228	OH2	TIP	S	71	43.118	110.363	−89.770	1.00	42.27		O
ATOM	1229	OH2	TIP	S	72	53.882	101.629	−81.807	1.00	30.94		O
ATOM	1230	OH2	TIP	S	73	31.345	105.239	−69.760	1.00	48.87		O
ATOM	1231	OH2	TIP	S	74	25.941	85.213	−81.998	1.00	61.06		O
ATOM	1232	OH2	TIP	S	75	47.139	108.628	−67.165	1.00	47.07		O
ATOM	1233	OH2	TIP	S	76	36.956	82.906	−76.340	1.00	30.49		O
ATOM	1234	OH2	TIP	S	77	44.646	86.956	−72.024	1.00	47.98		O
ATOM	1235	OH2	TIP	S	78	50.725	91.614	−63.564	1.00	35.57		O
ATOM	1236	OH2	TIP	S	79	21.998	92.127	−91.486	1.00	47.44		O
ATOM	1237	OH2	TIP	S	80	47.266	87.896	−88.765	1.00	40.08		O
ATOM	1238	OH2	TIP	S	81	24.525	97.089	−83.052	1.00	36.62		O
ATOM	1239	OH2	TIP	S	82	25.821	91.573	−68.249	1.00	41.99		O
ATOM	1240	OH2	TIP	S	83	34.713	82.268	−74.538	1.00	45.42		O
ATOM	1241	OH2	TIP	S	84	50.005	95.359	−62.322	1.00	37.75		O
ATOM	1242	OH2	TIP	S	85	42.153	85.977	−90.682	1.00	43.14		O
ATOM	1243	OH2	TIP	S	86	18.505	86.793	−83.931	1.00	42.01		O
ATOM	1244	OH2	TIP	S	87	34.355	108.946	−88.886	1.00	40.34		O
ATOM	1245	OH2	TIP	S	88	53.221	86.159	−68.264	1.00	41.36		O
ATOM	1246	OH2	TIP	S	89	19.204	90.567	−73.202	1.00	45.21		O
ATOM	1247	OH2	TIP	S	90	33.526	112.151	−76.169	1.00	47.42		O
ATOM	1248	OH2	TIP	S	91	39.849	88.806	−68.078	1.00	40.75		O
ATOM	1249	OH2	TIP	S	92	45.310	81.899	−79.875	1.00	42.32		O
ATOM	1250	OH2	TIP	S	93	28.805	84.754	−66.693	1.00	41.71		O
ATOM	1251	OH2	TIP	S	94	46.682	94.036	−83.802	1.00	21.76		O
ATOM	1252	OH2	TIP	S	95	40.626	91.047	−69.447	1.00	28.31		O
ATOM	1253	OH2	TIP	S	96	49.160	93.687	−80.396	1.00	33.38		O
ATOM	1254	OH2	TIP	S	97	45.166	89.424	−70.525	1.00	44.15		O
ATOM	1255	OH2	TIP	S	98	46.654	85.443	−72.900	1.00	50.39		O
ATOM	1256	OH2	TIP	S	99	41.247	108.915	−92.938	1.00	37.86		O
ATOM	1257	OH2	TIP	S	100	32.089	112.917	−73.986	1.00	34.52		O
ATOM	1258	OH2	TIP	S	101	51.281	107.764	−83.744	1.00	46.49		O
ATOM	1259	OH2	TIP	S	102	37.105	87.260	−92.888	1.00	47.81		O
ATOM	1260	OH2	TIP	S	103	35.387	82.572	−80.116	1.00	47.95		O
ATOM	1261	OH2	TIP	S	104	38.414	83.287	−80.796	1.00	38.64		O
ATOM	1262	OH2	TIP	S	105	25.283	100.226	−80.660	1.00	42.56		O
ATOM	1263	OH2	TIP	S	106	43.535	91.874	−71.251	1.00	37.97		O
ATOM	1264	OH2	TIP	S	107	49.646	110.064	−82.866	1.00	44.76		O
ATOM	1265	OH2	TIP	S	108	45.929	81.087	−89.510	1.00	54.16		O
ATOM	1266	OH2	TIP	S	109	54.977	101.974	−63.060	1.00	45.43		O
ATOM	1267	OH2	TIP	S	110	40.987	81.884	−75.639	1.00	46.24		O
ATOM	1268	OH2	TIP	S	111	52.104	94.013	−78.913	1.00	51.64		O
ATOM	1269	OH2	TIP	S	112	39.338	84.754	−70.979	1.00	42.99		O
ATOM	1270	OH2	TIP	S	113	43.616	99.385	−92.171	1.00	43.66		O
ATOM	1271	OH2	TIP	S	114	36.018	114.263	−74.511	1.00	30.72		O
ATOM	1272	OH2	TIP	S	115	45.847	94.011	−85.968	1.00	40.49		O
ATOM	1273	OH2	TIP	S	116	46.016	110.954	−71.456	1.00	47.81		O
ATOM	1274	OH2	TIP	S	117	44.513	114.302	−72.901	1.00	53.90		O
ATOM	1275	OH2	TIP	S	118	50.962	83.279	−62.390	1.00	61.22		O
ATOM	1276	OH2	TIP	S	119	47.020	93.741	−67.854	1.00	49.47		O
ATOM	1277	OH2	TIP	S	120	28.311	110.301	−77.416	1.00	51.56		O
ATOM	1278	OH2	TIP	S	121	40.484	112.927	−71.586	1.00	51.28		O
ATOM	1279	OH2	TIP	S	122	47.079	100.887	−90.865	1.00	42.60		O
ATOM	1280	OH2	TIP	S	123	18.931	89.924	−69.830	1.00	65.48		O
ATOM	1281	OH2	TIP	S	124	30.774	109.351	−85.188	1.00	58.50		O
ATOM	1282	OH2	TIP	S	125	30.468	102.147	−91.685	1.00	61.00		O
ATOM	1283	OH2	TIP	S	126	51.309	98.056	−61.812	1.00	49.51		O
ATOM	1284	OH2	TIP	S	127	36.974	80.645	−81.661	1.00	47.95		O
ATOM	1285	OH2	TIP	S	128	55.630	96.621	−60.667	1.00	54.25		O
ATOM	1286	OH2	TIP	S	129	25.808	99.363	−70.049	1.00	58.33		O
ATOM	1287	OH2	TIP	S	130	20.718	87.915	−70.182	1.00	53.58		O
ATOM	1288	OH2	TIP	S	131	14.944	91.204	−71.966	1.00	49.00		O
ATOM	1289	OH2	TIP	S	132	30.706	114.267	−88.445	1.00	46.32		O
ATOM	1290	OH2	TIP	S	133	25.963	102.889	−82.324	1.00	46.73		O
ATOM	1291	OH2	TIP	S	134	27.251	104.246	−80.470	1.00	55.57		O
ATOM	1292	OH2	TIP	S	135	11.818	92.001	−85.633	1.00	56.75		O
ATOM	1293	OH2	TIP	S	136	58.353	106.515	−75.598	1.00	54.23		O
ATOM	1294	OH2	TIP	S	137	51.150	102.437	−60.510	1.00	64.21		O
ATOM	1295	OH2	TIP	S	138	23.732	82.030	−82.878	1.00	45.88		O
ATOM	1296	OH2	TIP	S	139	41.420	87.391	−66.939	1.00	64.87		O
ATOM	1297	OH2	TIP	S	140	52.198	99.844	−80.990	1.00	37.17		O
ATOM	1298	OH2	TIP	S	141	19.795	92.125	−67.847	1.00	74.10		O
ATOM	1299	OH2	TIP	S	142	25.400	98.836	−66.728	1.00	61.76		O
ATOM	1300	OH2	TIP	S	143	27.980	98.080	−69.199	1.00	53.46		O
ATOM	1301	OH2	TIP	S	144	62.351	86.545	−63.345	1.00	67.01		O
ATOM	1302	OH2	TIP	S	145	29.019	93.103	−64.478	1.00	61.40		O
ATOM	1303	OH2	TIP	S	146	33.534	91.535	−66.206	1.00	48.23		O
ATOM	1304	OH2	TIP	S	147	31.924	96.329	−66.049	1.00	51.07		O
ATOM	1305	OH2	TIP	S	148	52.297	105.197	−76.211	1.00	47.94		O
ATOM	1306	OH2	TIP	S	149	64.486	89.161	−62.988	1.00	57.59		O
ATOM	1307	OH2	TIP	S	150	30.423	93.203	−61.399	1.00	74.96		O
ATOM	1308	OH2	TIP	S	151	48.960	108.294	−88.732	1.00	54.04		O
ATOM	1309	OH2	TIP	S	152	29.297	112.506	−77.035	1.00	57.06		O
ATOM	1310	OH2	TIP	S	153	25.147	83.913	−79.056	1.00	63.36		O
ATOM	1311	OH2	TIP	S	154	53.799	100.274	−61.424	1.00	83.07		O
ATOM	1312	OH2	TIP	S	155	54.765	100.624	−79.708	1.00	53.71		O
ATOM	1313	OH2	TIP	S	156	64.045	98.729	−71.705	1.00	59.95		O
ATOM	1314	OH2	TIP	S	157	28.776	102.323	−88.614	1.00	61.81		O
ATOM	1315	OH2	TIP	S	158	38.708	93.225	−66.167	1.00	51.98		O
ATOM	1316	OH2	TIP	S	159	50.807	108.034	−68.758	1.00	51.07		O
ATOM	1317	OH2	TIP	S	160	57.116	108.308	−78.580	1.00	75.81		O
ATOM	1318	OH2	TIP	S	161	42.409	116.570	−74.592	1.00	64.54		O
ATOM	1319	OH2	TIP	S	162	37.989	117.914	−91.780	1.00	72.93		O
TER	1320		TIP	S	162
ATOM	1321	O1	PGB	C	180	48.514	90.887	−68.146	1.00	42.43	O
ATOM	1322	C2	PGB	C	180	49.510	90.371	−67.356	1.00	41.14	C
ATOM	1323	C3	PGB	C	180	50.426	89.386	−68.116	1.00	39.51	C
ATOM	1324	O4	PGB	C	180	51.005	89.972	−69.177	1.00	36.54	O
ATOM	1325	C5	PGB	C	180	52.325	89.918	−69.146	1.00	30.79	C
ATOM	1326	C6	PGB	C	180	52.853	90.612	−70.393	1.00	27.83	C
ATOM	1327	O7	PGB	C	180	52.334	89.997	−71.488	1.00	25.49	O
ATOM	1328	C8	PGB	C	180	52.770	90.596	−72.619	1.00	23.93	C
ATOM	1329	C9	PGB	C	180	52.165	89.885	−73.840	1.00	25.97	C
ATOM	1330	O10	PGB	C	180	50.893	89.439	−73.566	1.00	23.28	O
ATOM	1331	C11	PGB	C	180	50.349	88.795	−74.637	1.00	19.63	C
ATOM	1332	C12	PGB	C	180	48.832	88.644	−74.414	1.00	21.63	C
ATOM	1333	O13	PGB	C	180	48.212	89.869	−74.455	1.00	21.22	O
ATOM	1334	C14	PGB	C	180	46.945	89.707	−74.015	1.00	20.73	C
ATOM	1335	C15	PGB	C	180	46.266	91.096	−73.745	1.00	20.29	C
ATOM	1336	O16	PGB	C	180	46.507	91.948	−74.769	1.00	20.00	O
ATOM	1337	C17	PGB	C	180	45.890	93.087	−74.528	1.00	26.07	C
ATOM	1338	C18	PGB	C	180	46.103	94.124	−75.648	1.00	26.71	C
ATOM	1339	O19	PGB	C	180	47.401	94.435	−75.676	1.00	28.38	O
ATOM	1340	C20	PGB	C	180	47.625	95.037	−76.821	1.00	34.40	C
ATOM	1341	C21	PGB	C	180	48.787	95.663	−77.584	1.00	35.84	C
ATOM	1342	O22	PGB	C	180	49.765	94.711	−77.691	1.00	41.19	O
TER	1343		PGB	C	180
ATOM	1344	C2	420	D	181	29.409	102.512	−83.178	1.00	44.95	C
ATOM	1345	C3	420	D	181	29.228	101.649	−82.070	1.00	43.04	C
ATOM	1346	N11	420	D	181	28.535	100.466	−82.231	1.00	40.67	N
ATOM	1347	C4	420	D	181	29.768	102.027	−80.794	1.00	43.30	C
ATOM	1348	O10	420	D	181	29.570	101.171	−79.733	1.00	41.69	O
ATOM	1349	C5	420	D	181	30.483	103.278	−80.644	1.00	44.77	C
ATOM	1350	C7	420	D	181	31.081	103.769	−79.309	1.00	45.52	C
ATOM	1351	O9	420	D	181	30.968	103.078	−78.306	1.00	45.53	O
ATOM	1352	O8	420	D	181	31.723	104.974	−79.240	1.00	46.59	O
ATOM	1353	C6	420	D	181	30.637	104.105	−81.783	1.00	45.63	C
ATOM	1354	C1	420	D	181	30.108	103.744	−83.059	1.00	46.86	C
ATOM	1355	N14	420	D	181	30.265	104.567	−84.154	1.00	48.36	N
ATOM	1356	O16	420	D	181	29.742	104.224	−85.416	1.00	51.77	O
ATOM	1357	O15	420	D	181	30.860	105.631	−84.071	1.00	51.52	O
TER	1358		420	D	181
ATOM	1359	O1	PGE	E	182	30.158	82.656	−82.944	1.00	78.51	O
ATOM	1360	C2	PGE	E	182	29.535	83.742	−82.406	1.00	79.19	C
ATOM	1361	C3	PGE	E	182	30.104	84.115	−81.019	1.00	79.22	C
ATOM	1362	O4	PGE	E	182	29.250	83.756	−80.047	1.00	80.28	O
ATOM	1363	C5	PGE	E	182	29.069	84.697	−79.111	1.00	79.37	C
ATOM	1364	C6	PGE	E	182	28.063	84.198	−78.029	1.00	78.19	C
ATOM	1365	O7	PGE	E	182	28.679	84.163	−76.813	1.00	77.95	O
ATOM	1366	C8	PGE	E	182	27.878	83.734	−75.818	1.00	77.77	C
ATOM	1367	C9	PGE	E	182	28.655	83.708	−74.470	1.00	77.35	C
ATOM	1368	O10	PGE	E	182	29.733	82.863	−74.535	1.00	76.68	O

[0196] Pin1 R14A/Pin-221 Interactions

[0197] The crystal structure of the PIN-221/R14A co-complex (the coordinate set is set forth in Table 4), shows a covalent interaction of Cys113 with PIN-221 and hydrogen bond interactions with Ser114. Other interactions involve van der Waals contacts with Ser154 and Ser171. A co-solvent molecule of N-methylpyrroleidione was also present, making a hydrogen bond with Gln131 and van der Waals contacts with Met130 and His157.

TABLE 4
Set of atomic coordinates of Pin1 R14A with PIN-221 and NMP bound in the
active site.
ATOM	1	CB	LEU		7	−56.410	14.231	−69.954	1.00	39.38	C
ATOM	2	CG	LEU		7	−57.344	15.296	−69.371	1.00	39.32	C
ATOM	3	CD1	LEU		7	−56.606	16.076	−68.301	1.00	38.07	C
ATOM	4	CD2	LEU		7	−57.834	16.228	−70.468	1.00	39.34	C
ATOM	5	C	LEU		7	−55.822	12.337	−71.456	1.00	40.26	C
ATOM	6	O	LEU		7	−55.423	11.355	−70.836	1.00	40.23	O
ATOM	7	N	LEU		7	−57.975	12.317	−70.220	1.00	42.02	N
ATOM	8	CA	LEU		7	−56.971	13.180	−70.919	1.00	40.26	C
ATOM	9	N	PRO		8	−55.268	12.716	−72.619	1.00	40.49	N
ATOM	10	CD	PRO		8	−55.710	13.815	−73.495	1.00	40.52	C
ATOM	11	CA	PRO		8	−54.150	11.982	−73.230	1.00	39.38	C
ATOM	12	CB	PRO		8	−53.855	12.788	−74.492	1.00	40.28	C
ATOM	13	CG	PRO		8	−55.190	13.374	−74.845	1.00	41.43	C
ATOM	14	C	PRO		8	−52.943	11.919	−72.295	1.00	38.38	C
ATOM	15	O	PRO		8	−52.859	12.668	−71.318	1.00	38.41	O
ATOM	16	N	PRO		9	−51.986	11.024	−72.596	1.00	36.88	N
ATOM	17	CD	PRO		9	−52.023	10.076	−73.721	1.00	36.33	C
ATOM	18	CA	PRO		9	−50.766	10.836	−71.801	1.00	34.43	C
ATOM	19	CB	PRO		9	−49.951	9.869	−72.656	1.00	36.23	C
ATOM	20	CG	PRO		9	−51.010	9.037	−73.302	1.00	36.23	C
ATOM	21	C	PRO		9	−49.994	12.119	−71.494	1.00	33.36	C
ATOM	22	O	PRO		9	−49.608	12.861	−72.402	1.00	31.76	O
ATOM	23	N	GLY		10	−49.772	12.366	−70.206	1.00	31.73	N
ATOM	24	CA	GLY		10	−49.027	13.537	−69.785	1.00	30.55	C
ATOM	25	C	GLY		10	−49.856	14.765	−69.450	1.00	28.68	C
ATOM	26	O	GLY		10	−49.375	15.660	−68.763	1.00	27.84	O
ATOM	27	N	TRP		11	−51.098	14.809	−69.923	1.00	30.03	N
ATOM	28	CA	TRP		11	−51.958	15.962	−69.677	1.00	30.64	C
ATOM	29	CB	TRP		11	−53.045	16.057	−70.755	1.00	28.59	C
ATOM	30	CG	TRP		11	−52.515	16.400	−72.108	1.00	27.18	C
ATOM	31	CD2	TRP		11	−52.221	17.714	−72.611	1.00	26.42	C
ATOM	32	CE2	TRP		11	−51.726	17.558	−73.922	1.00	24.60	C
ATOM	33	CE3	TRP		11	−52.317	19.004	−72.075	1.00	25.20	C
ATOM	34	CD1	TRP		11	−52.199	15.528	−73.110	1.00	25.73	C
ATOM	35	NE1	TRP		11	−51.727	16.213	−74.203	1.00	24.39	N
ATOM	36	CZ2	TRP		11	−51.341	18.641	−74.715	1.00	23.48	C
ATOM	37	CZ3	TRP		11	−51.934	20.084	−72.864	1.00	23.45	C
ATOM	38	CH2	TRP		11	−51.447	19.893	−74.168	1.00	25.15	C
ATOM	39	C	TRP		11	−52.613	15.996	−68.303	1.00	31.89	C
ATOM	40	O	TRP		11	−52.976	14.966	−67.740	1.00	32.03	O
ATOM	41	N	GLU		12	−52.758	17.206	−67.773	1.00	33.73	N
ATOM	42	CA	GLU		12	−53.368	17.423	−66.468	1.00	35.67	C
ATOM	43	CB	GLU		12	−52.305	17.362	−65.368	1.00	39.46	C
ATOM	44	CG	GLU		12	−51.210	18.404	−65.528	1.00	45.91	C
ATOM	45	CD	GLU		12	−50.226	18.418	−64.372	1.00	50.27	C
ATOM	46	OE1	GLU		12	−49.594	17.370	−64.109	1.00	52.31	O
ATOM	47	OE2	GLU		12	−50.086	19.482	−63.729	1.00	52.45	O
ATOM	48	C	GLU		12	−54.032	18.796	−66.443	1.00	35.73	C
ATOM	49	O	GLU		12	−53.668	19.684	−67.215	1.00	33.75	O
ATOM	50	N	LYS		13	−55.010	18.964	−65.562	1.00	36.27	N
ATOM	51	CA	LYS		13	−55.703	20.237	−65.434	1.00	37.13	C
ATOM	52	CB	LYS		13	−57.121	20.040	−64.894	1.00	40.41	C
ATOM	53	CG	LYS		13	−58.152	19.674	−65.940	1.00	43.54	C
ATOM	54	CD	LYS		13	−59.558	19.798	−65.366	1.00	46.43	C
ATOM	55	CE	LYS		13	−60.617	19.700	−66.457	1.00	48.80	C
ATOM	56	NZ	LYS		13	−61.987	19.970	−65.925	1.00	50.98	N
ATOM	57	C	LYS		13	−54.941	21.147	−64.488	1.00	36.52	C
ATOM	58	O	LYS		13	−54.283	20.685	−63.558	1.00	36.58	O
ATOM	59	N	ALA		14	−55.034	22.447	−64.736	1.00	34.79	N
ATOM	60	CA	ALA		14	−54.364	23.428	−63.901	1.00	34.15	C
ATOM	61	CB	ALA		14	−53.020	23.801	−64.503	1.00	32.48	C
ATOM	62	C	ALA		14	−55.256	24.657	−63.785	1.00	35.37	C
ATOM	63	O	ALA		14	−56.268	24.775	−64.483	1.00	31.55	O
ATOM	64	N	MET		15	−54.870	25.574	−62.906	1.00	36.26	N
ATOM	65	CA	MET		15	−55.638	26.792	−62.679	1.00	35.96	C
ATOM	66	CB	MET		15	−56.068	26.856	−61.209	1.00	38.28	C
ATOM	67	CG	MET		15	−56.721	28.159	−60.790	1.00	40.70	C
ATOM	68	SD	MET		15	−58.190	28.498	−61.760	1.00	44.63	S
ATOM	69	CE	MET		15	−59.303	27.228	−61.121	1.00	45.72	C
ATOM	70	C	MET		15	−54.816	28.020	−63.030	1.00	35.18	C
ATOM	71	O	MET		15	−53.701	28.190	−62.542	1.00	33.75	O
ATOM	72	N	SER		16	−55.366	28.876	−63.884	1.00	33.62	N
ATOM	73	CA	SER		16	−54.669	30.092	−64.274	1.00	33.78	C
ATOM	74	CB	SER		16	−55.420	30.796	−65.400	1.00	33.10	C
ATOM	75	OG	SER		16	−54.828	32.054	−65.682	1.00	36.20	O
ATOM	76	C	SER		16	−54.568	31.028	−63.077	1.00	33.89	C
ATOM	77	O	SER		16	−55.555	31.246	−62.379	1.00	33.19	O
ATOM	78	N	ARG		17	−53.383	31.578	−62.840	1.00	34.25	N
ATOM	79	CA	ARG		17	−53.192	32.498	−61.720	1.00	36.71	C
ATOM	80	CB	ARG		17	−51.716	32.557	−61.316	1.00	38.13	C
ATOM	81	CG	ARG		17	−51.320	31.506	−60.300	1.00	41.18	C
ATOM	82	CD	ARG		17	−49.832	31.540	−59.990	1.00	46.28	C
ATOM	83	NE	ARG		17	−49.467	30.534	−58.995	1.00	50.33	N
ATOM	84	CZ	ARG		17	−49.796	29.246	−59.075	1.00	52.00	C
ATOM	85	NH1	APG		17	−50.499	28.790	−60.105	1.00	54.92	N
ATOM	86	NH2	ARG		17	−49.435	28.407	−58.117	1.00	52.99	N
ATOM	87	C	ARG		17	−53.677	33.896	−62.071	1.00	36.83	C
ATOM	88	O	ARG		17	−53.978	34.701	−61.191	1.00	35.75	O
ATOM	89	N	SER		18	−53.752	34.178	−63.366	1.00	36.51	N
ATOM	90	CA	SER		18	−54.187	35.478	−63.844	1.00	38.08	C
ATOM	91	CB	SER		18	−53.535	35.780	−65.198	1.00	39.30	C
ATOM	92	OG	SER		18	−52.124	35.815	−65.091	1.00	43.42	O
ATOM	93	C	SER		18	−55.700	35.596	−63.997	1.00	37.49	C
ATOM	94	O	SER		18	−56.317	36.518	−63.463	1.00	38.43	O
ATOM	95	N	SER		19	−56.295	34.650	−64.721	1.00	36.40	N
ATOM	96	CA	SER		19	−57.726	34.679	−64.991	1.00	36.04	C
ATOM	97	CB	SER		19	−57.975	34.343	−66.465	1.00	37.15	C
ATOM	98	OG	SER		19	−57.576	33.016	−66.755	1.00	37.49	O
ATOM	99	C	SER		19	−58.601	33.779	−64.139	1.00	35.08	C
ATOM	100	O	SER		19	−59.812	33.987	−64.064	1.00	34.93	O
ATOM	101	N	GLY		20	−58.006	32.775	−63.506	1.00	34.21	N
ATOM	102	CA	GLY		20	−58.797	31.874	−62.689	1.00	32.88	C
ATOM	103	C	GLY		20	−59.521	30.849	−63.546	1.00	32.25	C
ATOM	104	O	GLY		20	−60.344	30.075	−63.056	1.00	33.75	O
ATOM	105	N	ARG		21	−59.221	30.851	−64.841	1.00	30.49	N
ATOM	106	CA	ARG		21	−59.829	29.907	−65.766	1.00	29.60	C
ATOM	107	CB	ARG		21	−59.903	30.512	−67.169	1.00	32.07	C
ATOM	108	CG	ARG		21	−61.234	30.302	−67.884	1.00	33.13	C
ATOM	109	CD	ARG		21	−61.118	30.676	−69.355	1.00	34.83	C
ATOM	110	NE	ARG		21	−60.312	31.882	−69.531	1.00	35.55	N
ATOM	111	CZ	ARG		21	−59.447	32.065	−70.523	1.00	35.22	C
ATOM	112	NH1	ARG		21	−59.269	31.125	−71.446	1.00	33.97	N
ATOM	113	NH2	ARG		21	−58.741	33.185	−70.583	1.00	36.74	N
ATOM	114	C	ARG		21	−58.934	28.669	−65.795	1.00	28.66	C
ATOM	115	O	ARG		21	−57.709	28.780	−65.690	1.00	28.10	O
ATOM	116	N	VAL		22	−59.532	27.494	−65.930	1.00	27.34	N
ATOM	117	CA	VAL		22	−58.734	26.275	−65.972	1.00	27.98	C
ATOM	118	CB	VAL		22	−59.600	25.010	−65.735	1.00	29.51	C
ATOM	119	CG1	VAL		22	−60.324	25.114	−64.400	1.00	32.84	C
ATOM	120	CG2	VAL		22	−60.596	24.835	−66.873	1.00	31.19	C
ATOM	121	C	VAL		22	−58.058	26.140	−67.333	1.00	25.86	C
ATOM	122	O	VAL		22	−58.557	26.639	−68.343	1.00	26.23	O
ATOM	123	N	TYR		23	−56.907	25.478	−67.351	1.00	24.20	N
ATOM	124	CA	TYR		23	−56.191	25.244	−68.594	1.00	23.75	C
ATOM	125	CB	TYR		23	−55.139	26.329	−68.843	1.00	23.76	C
ATOM	126	CG	TYR		23	−53.951	26.323	−67.904	1.00	26.59	C
ATOM	127	CD1	TYR		23	−52.753	25.707	−68.266	1.00	26.87	C
ATOM	128	CE1	TYR		23	−51.647	25.739	−67.422	1.00	28.14	C
ATOM	129	CD2	TYR		23	−54.014	26.967	−66.672	1.00	27.45	C
ATOM	130	CE2	TYR		23	−52.924	27.002	−65.824	1.00	28.77	C
ATOM	131	CZ	TYR		23	−51.739	26.389	−66.206	1.00	30.47	C
ATOM	132	OH	TYR		23	−50.649	26.432	−65.366	1.00	29.58	O
ATOM	133	C	TYR		23	−55.549	23.870	−68.490	1.00	23.93	C
ATOM	134	O	TYR		23	−55.659	23.206	−67.456	1.00	23.38	O
ATOM	135	N	TYR		24	−54.894	23.436	−69.556	1.00	21.84	N
ATOM	136	CA	TYR		24	−54.268	22.123	−69.561	1.00	22.71	C
ATOM	137	CB	TYR		24	−54.905	21.246	−70.637	1.00	23.34	C
ATOM	138	CG	TYR		24	−56.400	21.111	−70.450	1.00	27.59	C
ATOM	139	CD1	TYR		24	−57.267	22.131	−70.844	1.00	27.81	C
ATOM	140	CE1	TYR		24	−58.633	22.044	−70.608	1.00	29.99	C
ATOM	141	CD2	TYR		24	−56.939	19.996	−69.816	1.00	28.78	C
ATOM	142	CE2	TYR		24	−58.308	19.897	−69.573	1.00	31.48	C
ATOM	143	CZ	TYR		24	−59.146	20.924	−69.968	1.00	32.75	C
ATOM	144	OH	TYR		24	−60.498	20.833	−69.714	1.00	34.12	O
ATOM	145	C	TYR		24	−52.773	22.233	−69.770	1.00	21.33	C
ATOM	146	O	TYR		24	−52.299	23.081	−70.526	1.00	19.93	O
ATOM	147	N	PHE		25	−52.042	21.364	−69.085	1.00	22.74	N
ATOM	148	CA	PHE		25	−50.588	21.335	−69.136	1.00	23.11	C
ATOM	149	CB	PHE		25	−50.039	21.901	−67.823	1.00	25.42	C
ATOM	150	CG	PHE		25	−48.561	21.717	−67.649	1.00	28.35	C
ATOM	151	CD1	PHE		25	−47.657	22.489	−68.377	1.00	29.07	C
ATOM	152	CD2	PHE		25	−48.069	20.760	−66.762	1.00	30.03	C
ATOM	153	CE1	PHE		25	−46.273	22.307	−68.228	1.00	29.42	C
ATOM	154	CE2	PHE		25	−46.694	20.570	−66.607	1.00	30.76	C
ATOM	155	CZ	PHE		25	−45.794	21.349	−67.344	1.00	30.48	C
ATOM	156	C	PHE		25	−50.149	19.888	−69.307	1.00	23.65	C
ATOM	157	O	PHE		25	−50.804	18.972	−68.804	1.00	23.29	O
ATOM	158	N	ASN		26	−49.052	19.682	−70.033	1.00	22.66	N
ATOM	159	CA	ASN		26	−48.518	18.339	−70.251	1.00	22.04	C
ATOM	160	CB	ASN		26	−48.417	18.039	−71.747	1.00	20.72	C
ATOM	161	CG	ASN		26	−48.091	16.581	−72.021	1.00	21.83	C
ATOM	162	OD1	ASN		26	−47.036	16.086	−71.617	1.00	20.44	O
ATOM	163	ND2	ASN		26	−48.994	15.886	−72.706	1.00	20.94	N
ATOM	164	C	ASN		26	−47.137	18.308	−69.604	1.00	20.26	C
ATOM	165	O	ASN		26	−46.241	19.042	−70.018	1.00	19.47	O
ATOM	166	N	HIS		27	−46.968	17.468	−68.583	1.00	21.74	N
ATOM	167	CA	HIS		27	−45.694	17.411	−67.875	1.00	22.19	C
ATOM	168	CB	HIS		27	−45.887	16.871	−66.445	1.00	23.05	C
ATOM	169	CG	HIS		27	−46.465	15.492	−66.380	1.00	25.37	C
ATOM	170	CD2	HIS		27	−47.714	15.062	−66.077	1.00	26.79	C
ATOM	171	ND1	HIS		27	−45.724	14.359	−66.643	1.00	29.55	N
ATOM	172	CE1	HIS		27	−46.491	13.291	−66.503	1.00	29.10	C
ATOM	173	NE2	HIS		27	−47.703	13.692	−66.160	1.00	28.90	N
ATOM	174	C	HIS		27	−44.590	16.643	−68.590	1.00	22.17	C
ATOM	175	O	HIS		27	−43.476	16.549	−68.086	1.00	21.17	O
ATOM	176	N	ILE		28	−44.893	16.112	−69.768	1.00	22.93	N
ATOM	177	CA	ILE		28	−43.894	15.391	−70.546	1.00	23.87	C
ATOM	178	CB	ILE		28	−44.479	14.114	−71.199	1.00	23.89	C
ATOM	179	CG2	ILE		28	−43.361	13.330	−71.892	1.00	23.45	C
ATOM	180	CG1	ILE		28	−45.128	13.228	−70.135	1.00	24.05	C
ATOM	181	CD1	ILE		28	−45.862	12.019	−70.704	1.00	23.04	C
ATOM	182	C	ILE		28	−43.372	16.302	−71.665	1.00	24.77	C
ATOM	183	O	ILE		28	−42.169	16.355	−71.926	1.00	25.85	O
ATOM	184	N	THR		29	−44.281	17.028	−72.311	1.00	23.94	N
ATOM	185	CA	THR		29	−43.916	17.923	−73.417	1.00	22.06	C
ATOM	186	CB	THR		29	−44.960	17.876	−74.528	1.00	21.36	C
ATOM	187	OG1	THR		29	−46.156	18.514	−74.067	1.00	20.81	O
ATOM	188	CG2	THR		29	−45.280	16.446	−74.906	1.00	19.80	C
ATOM	189	C	THR		29	−43.815	19.382	−72.990	1.00	21.58	C
ATOM	190	O	THR		29	−43.270	20.209	−73.721	1.00	20.87	O
ATOM	191	N	ASN		30	−44.344	19.685	−71.808	1.00	22.03	N
ATOM	192	CA	ASN		30	−44.376	21.043	−71.266	1.00	20.90	C
ATOM	193	CB	ASN		30	−42.970	21.631	−71.141	1.00	20.66	C
ATOM	194	CG	ASN		30	−42.218	21.078	−69.941	1.00	23.68	C
ATOM	195	OD1	ASN		30	−42.825	20.760	−68.920	1.00	22.19	O
ATOM	196	ND2	ASN		30	−40.894	20.974	−70.056	1.00	21.52	N
ATOM	197	C	ASN		30	−45.276	21.987	−72.071	1.00	19.91	C
ATOM	198	O	ASN		30	−45.145	23.209	−71.990	1.00	20.71	O
ATOM	199	N	ALA		31	−46.181	21.413	−72.854	1.00	19.06	N
ATOM	200	CA	ALA		31	−47.122	22.214	−73.625	1.00	20.25	C
ATOM	201	CB	ALA		31	−47.764	21.371	−74.707	1.00	21.52	C
ATOM	202	C	ALA		31	−48.192	22.684	−72.647	1.00	21.26	C
ATOM	203	O	ALA		31	−48.469	22.011	−71.644	1.00	20.03	O
ATOM	204	N	SER		32	−48.782	23.844	−72.923	1.00	21.11	N
ATOM	205	CA	SER		32	−49.850	24.381	−72.083	1.00	21.25	C
ATOM	206	CB	SER		32	−49.290	25.313	−70.997	1.00	22.58	C
ATOM	207	OG	SER		32	−48.492	26.346	−71.541	1.00	25.45	O
ATOM	208	C	SER		32	−50.811	25.120	−73.004	1.00	21.97	C
ATOM	209	O	SER		32	−50.387	25.853	−73.893	1.00	20.51	O
ATOM	210	N	GLN		33	−52.106	24.903	−72.800	1.00	21.88	N
ATOM	211	CA	GLN		33	−53.128	25.507	−73.651	1.00	22.81	C
ATOM	212	CB	GLN		33	−53.332	24.615	−74.881	1.00	22.40	C
ATOM	213	CG	GLN		33	−53.830	23.203	−74.539	1.00	24.37	C
ATOM	214	CD	GLN		33	−53.673	22.217	−75.686	1.00	27.62	C
ATOM	215	OE1	GLN		33	−54.470	21.280	−75.838	1.00	29.68	O
ATOM	216	NE2	GLN		33	−52.635	22.407	−76.491	1.00	23.21	N
ATOM	217	C	GLN		33	−54.447	25.647	−72.894	1.00	21.82	C
ATOM	218	O	GLN		33	−54.637	25.009	−71.861	1.00	23.05	O
ATOM	219	N	TRP		34	−55.353	26.476	−73.408	1.00	22.50	N
ATOM	220	CA	TRP		34	−56.663	26.659	−72.771	1.00	22.75	C
ATOM	221	CB	TRP		34	−57.331	27.968	−73.226	1.00	21.17	C
ATOM	222	CG	TRP		34	−56.623	29.216	−72.792	1.00	18.63	C
ATOM	223	CD2	TRP		34	−56.430	29.669	−71.446	1.00	19.23	C
ATOM	224	CE2	TRP		34	−55.679	30.861	−71.510	1.00	20.74	C
ATOM	225	CE3	TRP		34	−56.816	29.180	−70.191	1.00	18.54	C
ATOM	226	CD1	TRP		34	−56.009	30.129	−73.596	1.00	21.25	C
ATOM	227	NE1	TRP		34	−55.438	31.121	−72.835	1.00	22.11	N
ATOM	228	CZ2	TRP		34	−55.307	31.573	−70.372	1.00	21.10	C
ATOM	229	CZ3	TRP		34	−56.444	29.886	−69.061	1.00	21.07	C
ATOM	230	CH2	TRP		34	−55.694	31.072	−69.159	1.00	21.99	C
ATOM	231	C	TRP		34	−57.585	25.511	−73.159	1.00	24.08	C
ATOM	232	O	TRP		34	−58.355	25.004	−72.340	1.00	24.51	O
ATOM	233	N	GLU		35	−57.496	25.119	−74.424	1.00	25.70	N
ATOM	234	CA	GLU		35	−58.322	24.064	−74.998	1.00	27.30	C
ATOM	235	CB	GLU		35	−58.157	24.057	−76.522	1.00	28.78	C
ATOM	236	CG	GLU		35	−58.531	25.365	−77.218	1.00	28.73	C
ATOM	237	CD	GLU		35	−57.436	26.415	−77.145	1.00	29.39	C
ATOM	238	OE1	GLU		35	−57.697	27.578	−77.528	1.00	29.15	O
ATOM	239	OE2	GLU		35	−56.311	26.080	−76.716	1.00	26.63	O
ATOM	240	C	GLU		35	−58.045	22.662	−74.460	1.00	30.11	C
ATOM	241	O	GLU		35	−56.893	22.274	−74.269	1.00	28.19	O
ATOM	242	N	ARG		36	−59.112	21.902	−74.226	1.00	31.77	N
ATOM	243	CA	ARG		36	−58.977	20.541	−73.731	1.00	36.40	C
ATOM	244	CB	ARG		36	−60.354	19.966	−73.373	1.00	39.28	C
ATOM	245	CG	ARG		36	−60.309	18.625	−72.647	1.00	44.26	C
ATOM	246	CD	ARG		36	−61.710	18.051	−72.475	1.00	49.03	C
ATOM	247	NE	ARG		36	−61.726	16.780	−71.750	1.00	52.82	N
ATOM	248	CZ	ARG		36	−61.634	16.661	−70.426	1.00	54.57	C
ATOM	249	NH1	ARG		36	−61.522	17.741	−69.662	1.00	55.16	N
ATOM	250	NH2	ARG		36	−61.665	15.459	−69.865	1.00	55.50	N
ATOM	251	C	ARG		36	−58.344	19.709	−74.848	1.00	37.21	C
ATOM	252	O	ARG		36	−58.843	19.686	−75.973	1.00	37.46	O
ATOM	253	N	PRO		37	−57.230	19.020	−74.553	1.00	37.60	N
ATOM	254	CD	PRO		37	−56.580	18.870	−73.241	1.00	36.82	C
ATOM	255	CA	PRO		37	−56.556	18.203	−75.570	1.00	39.97	C
ATOM	256	CB	PRO		37	−55.318	17.692	−74.832	1.00	38.84	C
ATOM	257	CG	PRO		37	−55.794	17.590	−73.419	1.00	37.32	C
ATOM	258	C	PRO		37	−57.415	17.066	−76.137	1.00	42.18	C
ATOM	259	O	PRO		37	−58.161	16.409	−75.406	1.00	42.61	O
ATOM	260	N	SER		38	−57.293	16.848	−77.444	1.00	44.85	N
ATOM	261	CA	SER		38	−58.037	15.802	−78.146	1.00	47.39	C
ATOM	262	CB	SER		38	−57.602	15.745	−79.614	1.00	48.61	C
ATOM	263	OG	SER		38	−57.746	17.005	−80.248	1.00	49.94	O
ATOM	264	C	SER		38	−57.814	14.436	−77.506	1.00	47.97	C
ATOM	265	O	SER		38	−56.707	13.900	−77.542	1.00	48.17	O
ATOM	266	N	GLU		51	−48.869	3.556	−78.910	1.00	56.73	N
ATOM	267	CA	GLU		51	−48.210	4.726	−79.479	1.00	56.61	C
ATOM	268	CB	GLU		51	−47.139	5.253	−78.516	1.00	56.78	C
ATOM	269	CG	GLU		51	−45.888	4.388	−78.449	1.00	56.13	C
ATOM	270	CD	GLU		51	−44.790	4.995	−77.592	1.00	56.29	C
ATOM	271	OE1	GLU		51	−43.677	4.431	−77.577	1.00	56.48	O
ATOM	272	OE2	GLU		51	−45.038	6.028	−76.931	1.00	56.26	O
ATOM	273	C	GLU		51	−47.554	4.362	−80.808	1.00	56.01	C
ATOM	274	O	GLU		51	−47.310	3.186	−81.087	1.00	56.46	O
ATOM	275	N	PRO		52	−47.263	5.371	−81.650	1.00	54.73	N
ATOM	276	CD	PRO		52	−47.629	6.790	−81.493	1.00	54.54	C
ATOM	277	CA	PRO		52	−46.631	5.142	−82.954	1.00	52.81	C
ATOM	278	CB	PRO		52	−46.516	6.550	−83.533	1.00	53.21	C
ATOM	279	CG	PRO		52	−47.684	7.260	−82.926	1.00	54.26	C
ATOM	280	C	PRO		52	−45.264	4.476	−82.805	1.00	51.22	C
ATOM	281	O	PRO		52	−44.590	4.649	−81.790	1.00	51.92	O
ATOM	282	N	ALA		53	−44.860	3.717	−83.818	1.00	48.36	N
ATOM	283	CA	ALA		53	−43.569	3.044	−83.795	1.00	45.29	C
ATOM	284	CB	ALA		53	−43.554	1.913	−84.807	1.00	45.58	C
ATOM	285	C	ALA		53	−42.482	4.054	−84.128	1.00	43.82	C
ATOM	286	O	ALA		53	−41.333	3.927	−83.696	1.00	41.97	O
ATOM	287	N	ARG		54	−42.862	5.064	−84.906	1.00	41.76	N
ATOM	288	CA	ARG		54	−41.940	6.116	−85.315	1.00	39.39	C
ATOM	289	CB	ARG		54	−41.325	5.779	−86.675	1.00	41.84	C
ATOM	290	CG	ARG		54	−40.620	4.434	−86.734	1.00	46.43	C
ATOM	291	CD	ARG		54	−40.372	4.011	−88.173	1.00	48.42	C
ATOM	292	NE	ARG		54	−39.518	4.952	−88.891	1.00	50.78	N
ATOM	293	CZ	ARG		54	−38.237	5.169	−88.602	1.00	52.53	C
ATOM	294	NH1	ARG		54	−37.660	4.513	−87.603	1.00	54.12	N
ATOM	295	NH2	ARG		54	−37.533	6.034	−89.320	1.00	53.96	N
ATOM	296	C	ARG		54	−42.676	7.441	−85.429	1.00	36.18	C
ATOM	297	O	ARG		54	−43.873	7.479	−85.710	1.00	34.65	O
ATOM	298	N	VAL		55	−41.950	8.527	−85.203	1.00	32.83	N
ATOM	299	CA	VAL		55	−42.524	9.857	−85.326	1.00	30.15	C
ATOM	300	CB	VAL		55	−42.811	10.517	−83.941	1.00	28.86	C
ATOM	301	CG1	VAL		55	−43.813	9.682	−83.161	1.00	28.16	C
ATOM	302	CG2	VAL		55	−41.515	10.690	−83.153	1.00	27.14	C
ATOM	303	C	VAL		55	−41.524	10.725	−86.067	1.00	28.50	C
ATOM	304	O	VAL		55	−40.322	10.451	−86.068	1.00	28.45	O
ATOM	305	N	ARG		56	−42.026	11.759	−86.724	1.00	25.58	N
ATOM	306	CA	ARG		56	−41.154	12.678	−87.422	1.00	22.50	C
ATOM	307	CB	ARG		56	−41.541	12.780	−88.894	1.00	21.90	C
ATOM	308	CG	ARG		56	−40.607	13.673	−89.679	1.00	22.73	C
ATOM	309	CD	ARG		56	−41.005	13.740	−91.136	1.00	22.20	C
ATOM	310	NE	ARG		56	−40.028	14.491	−91.919	1.00	25.01	N
ATOM	311	CZ	ARG		56	−40.148	14.723	−93.220	1.00	26.61	C
ATOM	312	NH1	ARG		56	−41.209	14.259	−93.876	1.00	25.11	N
ATOM	313	NH2	ARG		56	−39.217	15.417	−93.862	1.00	24.53	N
ATOM	314	C	ARG		56	−41.325	14.026	−86.739	1.00	22.03	C
ATOM	315	O	ARG		56	−42.455	14.486	−86.541	1.00	21.05	O
ATOM	316	N	CYS		57	−40.207	14.652	−86.365	1.00	19.68	N
ATOM	317	CA	CYS		57	−40.254	15.946	−85.697	1.00	18.91	C
ATOM	318	CB	CYS		57	−40.013	15.790	−84.185	1.00	17.90	C
ATOM	319	SG	CYS		57	−41.212	14.769	−83.297	1.00	21.12	S
ATOM	320	C	CYS		57	−39.227	16.937	−86.213	1.00	20.35	C
ATOM	321	O	CYS		57	−38.198	16.568	−86.795	1.00	19.47	O
ATOM	322	N	SER		58	−39.533	18.208	−85.998	1.00	18.42	N
ATOM	323	CA	SER		58	−38.624	19.283	−86.331	1.00	18.34	C
ATOM	324	CB	SER		58	−39.271	20.285	−87.284	1.00	18.37	C
ATOM	325	OG	SER		58	−39.552	19.688	−88.538	1.00	21.68	O
ATOM	326	C	SER		58	−38.393	19.915	−84.959	1.00	20.07	C
ATOM	327	O	SER		58	−39.166	19.683	−84.022	1.00	20.92	O
ATOM	328	N	HIS		59	−37.321	20.680	−84.811	1.00	21.09	N
ATOM	329	CA	HIS		59	−37.073	21.319	−83.532	1.00	21.22	C
ATOM	330	CB	HIS		59	−36.325	20.381	−82.574	1.00	22.72	C
ATOM	331	CG	HIS		59	−34.879	20.197	−82.911	1.00	23.97	C
ATOM	332	CD2	HIS		59	−34.267	19.865	−84.073	1.00	24.66	C
ATOM	333	ND1	HIS		59	−33.873	20.364	−81.984	1.00	25.54	N
ATOM	334	CE1	HIS		59	−32.704	20.145	−82.561	1.00	26.41	C
ATOM	335	NE2	HIS		59	−32.915	19.841	−83.827	1.00	25.59	N
ATOM	336	C	HIS		59	−36.266	22.582	−83.718	1.00	20.66	C
ATOM	337	O	HIS		59	−35.702	22.830	−84.788	1.00	18.63	O
ATOM	338	N	LEU		60	−36.247	23.380	−82.658	1.00	20.46	N
ATOM	339	CA	LEU		60	−35.506	24.627	−82.613	1.00	20.41	C
ATOM	340	CB	LEU		60	−36.452	25.831	−82.529	1.00	19.84	C
ATOM	341	CG	LEU		60	−35.803	27.203	−82.759	1.00	20.17	C
ATOM	342	CD1	LEU		60	−36.888	28.241	−83.017	1.00	21.15	C
ATOM	343	CD2	LEU		60	−34.950	27.594	−81.562	1.00	17.61	C
ATOM	344	C	LEU		60	−34.722	24.484	−81.321	1.00	22.65	C
ATOM	345	O	LEU		60	−35.301	24.363	−80.238	1.00	22.36	O
ATOM	346	N	LEU		61	−33.400	24.475	−81.435	1.00	22.98	N
ATOM	347	CA	LEU		61	−32.558	24.321	−80.264	1.00	23.30	C
ATOM	348	CB	LEU		61	−31.530	23.205	−80.509	1.00	24.05	C
ATOM	349	CG	LEU		61	−30.413	23.035	−79.470	1.00	25.37	C
ATOM	350	CD1	LEU		61	−30.999	22.653	−78.122	1.00	23.91	C
ATOM	351	CD2	LEU		61	−29.435	21.965	−79.950	1.00	25.78	C
ATOM	352	C	LEU		61	−31.834	25.599	−79.893	1.00	22.89	C
ATOM	353	O	LEU		61	−31.290	26.289	−80.750	1.00	23.54	O
ATOM	354	N	VAL		62	−31.858	25.924	−78.608	1.00	24.14	N
ATOM	355	CA	VAL		62	−31.151	27.088	−78.112	1.00	24.92	C
ATOM	356	CB	VAL		62	−32.101	28.132	−77.477	1.00	26.28	C
ATOM	357	CG1	VAL		62	−31.295	29.293	−76.906	1.00	25.58	C
ATOM	358	CG2	VAL		62	−33.064	28.660	−78.533	1.00	25.43	C
ATOM	359	C	VAL		62	−30.191	26.543	−77.063	1.00	26.85	C
ATOM	360	O	VAL		62	−30.606	25.972	−76.048	1.00	25.08	O
ATOM	361	N	LYS		63	−28.900	26.685	−77.341	1.00	27.56	N
ATOM	362	CA	LYS		63	−27.870	26.209	−76.433	1.00	30.11	C
ATOM	363	CB	LYS		63	−26.628	25.774	−77.221	1.00	29.50	C
ATOM	364	CG	LYS		63	−26.833	24.509	−78.031	1.00	32.93	C
ATOM	365	CD	LYS		63	−25.532	24.031	−78.658	1.00	35.79	C
ATOM	366	CE	LYS		63	−25.624	22.564	−79.022	1.00	36.57	C
ATOM	367	NZ	LYS		63	−24.357	22.064	−79.607	1.00	39.73	N
ATOM	368	C	LYS		63	−27.494	27.300	−75.451	1.00	29.74	C
ATOM	369	O	LYS		63	−27.847	28.467	−75.642	1.00	29.85	O
ATOM	370	N	HIS		64	−26.789	26.909	−74.396	1.00	30.90	N
ATOM	371	CA	HIS		64	−26.335	27.845	−73.376	1.00	33.12	C
ATOM	372	CB	HIS		64	−27.344	27.912	−72.222	1.00	32.01	C
ATOM	373	CG	HIS		64	−27.772	26.571	−71.713	1.00	32.69	C
ATOM	374	CD2	HIS		64	−28.925	25.883	−71.880	1.00	32.39	C
ATOM	375	ND1	HIS		64	−26.952	25.766	−70.951	1.00	32.58	N
ATOM	376	CE1	HIS		64	−27.582	24.637	−70.674	1.00	33.98	C
ATOM	377	NE2	HIS		64	−28.783	24.684	−71.225	1.00	33.29	N
ATOM	378	C	HIS		64	−24.969	27.388	−72.875	1.00	34.96	C
ATOM	379	O	HIS		64	−24.488	26.311	−73.253	1.00	34.80	O
ATOM	380	N	SER		65	−24.347	28.203	−72.028	1.00	35.87	N
ATOM	381	CA	SER		65	−23.023	27.890	−71.493	1.00	37.77	C
ATOM	382	CB	SER		65	−22.551	29.014	−70.563	1.00	37.31	C
ATOM	383	OG	SER		65	−23.420	29.172	−69.458	1.00	38.71	O
ATOM	384	C	SER		65	−22.919	26.539	−70.776	1.00	38.42	C
ATOM	385	O	SER		65	−21.818	26.040	−70.554	1.00	40.45	O
ATOM	386	N	GLN		66	−24.050	25.940	−70.414	1.00	38.44	N
ATOM	387	CA	GLN		66	−24.008	24.645	−69.745	1.00	39.20	C
ATOM	388	CB	GLN		66	−24.954	24.607	−68.539	1.00	42.80	C
ATOM	389	CG	GLN		66	−24.410	25.271	−67.277	1.00	45.54	C
ATOM	390	CD	GLN		66	−25.172	24.848	−66.020	1.00	48.36	C
ATOM	391	OE1	GLN		66	−25.111	23.685	−65.598	1.00	47.36	O
ATOM	392	NE2	GLN		66	−25.898	25.790	−65.423	1.00	48.10	N
ATOM	393	C	GLN		66	−24.340	23.480	−70.672	1.00	38.29	C
ATOM	394	O	GLN		66	−24.460	22.343	−70.223	1.00	38.60	O
ATOM	395	N	SER		67	−24.501	23.760	−71.963	1.00	37.66	N
ATOM	396	CA	SER		67	−24.798	22.708	−72.928	1.00	37.44	C
ATOM	397	CB	SER		67	−25.128	23.319	−74.295	1.00	37.14	C
ATOM	398	OG	SER		67	−26.273	24.158	−74.224	1.00	34.86	O
ATOM	399	C	SER		67	−23.556	21.829	−73.035	1.00	38.94	C
ATOM	400	O	SER		67	−22.436	22.337	−73.010	1.00	37.92	O
ATOM	401	N	ARG		68	−23.748	20.517	−73.145	1.00	40.00	N
ATOM	402	CA	ARG		68	−22.615	19.598	−73.237	1.00	43.53	C
ATOM	403	CB	ARG		68	−23.069	18.228	−73.742	1.00	43.61	C
ATOM	404	CG	ARG		68	−22.020	17.138	−73.564	1.00	46.89	C
ATOM	405	CD	ARG		68	−21.574	17.024	−72.102	1.00	47.18	C
ATOM	406	NE	ARG		68	−22.579	16.397	−71.244	1.00	48.41	N
ATOM	407	CZ	ARG		68	−22.528	16.378	−69.911	1.00	49.06	C
ATOM	408	NH1	ARG		68	−21.521	16.959	−69.269	1.00	49.37	N
ATOM	409	NH2	ARG		68	−23.479	15.767	−69.218	1.00	47.65	N
ATOM	410	C	ARG		68	−21.561	20.173	−74.173	1.00	44.90	C
ATOM	411	O	ARG		68	−20.363	20.144	−73.871	1.00	46.32	O
ATOM	412	N	ARG		69	−22.013	20.700	−75.307	1.00	45.24	N
ATOM	413	CA	ARG		69	−21.126	21.315	−76.289	1.00	44.58	C
ATOM	414	CB	ARG		69	−21.114	20.489	−77.581	1.00	47.59	C
ATOM	415	CG	ARG		69	−19.953	19.509	−77.665	1.00	53.48	C
ATOM	416	CD	ARG		69	−20.302	18.294	−78.514	1.00	58.03	C
ATOM	417	NE	ARG		69	−20.134	17.056	−77.749	1.00	62.40	N
ATOM	418	CZ	ARG		69	−20.995	16.041	−77.768	1.00	64.81	C
ATOM	419	NH1	ARG		69	−22.092	16.108	−78.517	1.00	66.14	N
ATOM	420	NH2	ARG		69	−20.766	14.963	−77.033	1.00	66.14	N
ATOM	421	C	ARG		69	−21.595	22.739	−76.574	1.00	41.87	C
ATOM	422	O	ARG		69	−22.393	22.974	−77.477	1.00	41.41	O
ATOM	423	N	PRO		70	−21.101	23.711	−75.793	1.00	40.54	N
ATOM	424	CD	PRO		70	−20.115	23.533	−74.714	1.00	40.41	C
ATOM	425	CA	PRO		70	−21.462	25.124	−75.944	1.00	39.06	C
ATOM	426	CB	PRO		70	−20.842	25.766	−74.706	1.00	39.39	C
ATOM	427	CG	PRO		70	−19.609	24.945	−74.502	1.00	40.22	C
ATOM	428	C	PRO		70	−20.952	25.742	−77.243	1.00	37.39	C
ATOM	429	O	PRO		70	−20.267	26.765	−77.231	1.00	35.50	O
ATOM	430	N	SER		71	−21.314	25.120	−78.362	1.00	36.41	N
ATOM	431	CA	SER		71	−20.890	25.589	−79.675	1.00	36.25	C
ATOM	432	CB	SER		71	−19.486	25.050	−79.970	1.00	36.36	C
ATOM	433	OG	SER		71	−19.020	25.486	−81.229	1.00	39.90	O
ATOM	434	C	SER		71	−21.868	25.119	−80.752	1.00	34.57	C
ATOM	435	O	SER		71	−22.451	24.042	−80.632	1.00	35.34	O
ATOM	436	N	SER		72	−22.047	25.930	−81.798	1.00	34.27	N
ATOM	437	CA	SER		72	−22.949	25.578	−82.903	1.00	33.21	C
ATOM	438	CB	SER		72	−24.400	25.940	−82.561	1.00	32.41	C
ATOM	439	OG	SER		72	−24.611	27.342	−82.617	1.00	29.71	O
ATOM	440	C	SER		72	−22.546	26.316	−84.175	1.00	32.55	C
ATOM	441	O	SER		72	−21.638	27.135	−84.151	1.00	31.56	O
ATOM	442	N	TRP		73	−23.234	26.031	−85.279	1.00	33.11	N
ATOM	443	CA	TRP		73	−22.943	26.683	−86.553	1.00	32.71	C
ATOM	444	CB	TRP		73	−23.793	26.084	−87.682	1.00	33.20	C
ATOM	445	CG	TRP		73	−25.265	26.397	−87.568	1.00	34.29	C
ATOM	446	CD2	TRP		73	−25.941	27.559	−88.081	1.00	34.76	C
ATOM	447	CE2	TRP		73	−27.293	27.456	−87.702	1.00	34.40	C
ATOM	448	CE3	TRP		73	−25.526	28.671	−88.823	1.00	35.27	C
ATOM	449	CD1	TRP		73	−26.215	25.662	−86.918	1.00	34.16	C
ATOM	450	NE1	TRP		73	−27.436	26.292	−86.992	1.00	33.46	N
ATOM	451	CZ2	TRP		73	−28.241	28.431	−88.033	1.00	33.94	C
ATOM	452	CZ3	TRP		73	−26.467	29.640	−89.152	1.00	35.68	C
ATOM	453	CH2	TRP		73	−27.810	29.511	−88.756	1.00	35.43	C
ATOM	454	C	TRP		73	−23.212	28.184	−86.479	1.00	32.61	C
ATOM	455	O	TRP		73	−22.702	28.954	−87.289	1.00	33.31	O
ATOM	456	N	ARG		74	−24.019	28.600	−85.505	1.00	32.46	N
ATOM	457	CA	ARG		74	−24.350	30.013	−85.344	1.00	33.13	C
ATOM	458	CB	ARG		74	−25.684	30.192	−84.611	1.00	32.17	C
ATOM	459	CG	ARG		74	−26.900	29.530	−85.222	1.00	33.22	C
ATOM	460	CD	ARG		74	−28.157	30.088	−84.555	1.00	32.21	C
ATOM	461	NE	ARG		74	−28.273	31.519	−84.806	1.00	32.61	N
ATOM	462	CZ	ARG		74	−28.554	32.431	−83.879	1.00	33.47	C
ATOM	463	NH1	ARG		74	−28.758	32.066	−82.623	1.00	35.15	N
ATOM	464	NH2	ARG		74	−28.620	33.715	−84.214	1.00	35.56	N
ATOM	465	C	ARG		74	−23.310	30.779	−84.541	1.00	33.76	C
ATOM	466	O	ARG		74	−23.080	31.963	−84.779	1.00	34.11	O
ATOM	467	N	GLN		75	−22.697	30.105	−83.576	1.00	35.42	N
ATOM	468	CA	GLN		75	−21.732	30.759	−82.707	1.00	37.21	C
ATOM	469	CB	GLN		75	−22.480	31.303	−81.493	1.00	39.96	C
ATOM	470	CG	GLN		75	−22.041	32.656	−81.007	1.00	43.37	C
ATOM	471	CD	GLN		75	−22.827	33.079	−79.786	1.00	45.81	C
ATOM	472	OE1	GLN		75	−22.491	34.062	−79.128	1.00	48.68	O
ATOM	473	NE2	GLN		75	−23.888	32.339	−79.477	1.00	45.90	N
ATOM	474	C	GLN		75	−20.673	29.760	−82.258	1.00	36.99	C
ATOM	475	O	GLN		75	−21.007	28.697	−81.734	1.00	37.14	O
ATOM	476	N	GLU		76	−19.401	30.101	−82.459	1.00	36.13	N
ATOM	477	CA	GLU		76	−18.313	29.201	−82.090	1.00	36.03	C
ATOM	478	CB	GLU		76	−16.959	29.763	−82.550	1.00	35.73	C
ATOM	479	CG	GLU		76	−15.834	28.736	−82.476	1.00	34.73	C
ATOM	480	CD	GLU		76	−14.598	29.127	−83.275	1.00	34.26	C
ATOM	481	OE1	GLU		76	−13.695	28.273	−83.400	1.00	32.60	O
ATOM	482	OE2	GLU		76	−14.524	30.273	−83.773	1.00	31.82	O
ATOM	483	C	GLU		76	−18.287	28.930	−80.592	1.00	36.15	C
ATOM	484	O	GLU		76	−18.100	27.792	−80.163	1.00	35.25	O
ATOM	485	N	LYS		77	−18.490	29.979	−79.803	1.00	37.65	N
ATOM	486	CA	LYS		77	−18.504	29.868	−78.349	1.00	39.55	C
ATOM	487	CB	LYS		77	−17.329	30.656	−77.760	1.00	42.19	C
ATOM	488	CG	LYS		77	−17.245	30.637	−76.241	1.00	46.02	C
ATOM	489	CD	LYS		77	−16.147	31.575	−75.753	1.00	49.42	C
ATOM	490	CE	LYS		77	−16.029	31.568	−74.233	1.00	50.45	C
ATOM	491	NZ	LYS		77	−15.649	30.226	−73.712	1.00	52.56	N
ATOM	492	C	LYS		77	−19.824	30.415	−77.795	1.00	38.19	C
ATOM	493	O	LYS		77	−20.032	31.628	−77.757	1.00	38.22	O
ATOM	494	N	ILE		78	−20.713	29.520	−77.375	1.00	37.80	N
ATOM	495	CA	ILE		78	−22.004	29.923	−76.817	1.00	37.46	C
ATOM	496	CB	ILE		78	−23.024	28.748	−76.824	1.00	37.29	C
ATOM	497	CG2	ILE		78	−24.357	29.213	−76.237	1.00	36.08	C
ATOM	498	CG1	ILE		78	−23.216	28.210	−78.244	1.00	36.10	C
ATOM	499	CD1	ILE		78	−23.881	29.173	−79.182	1.00	36.94	C
ATOM	500	C	ILE		78	−21.790	30.359	−75.369	1.00	37.35	C
ATOM	501	O	ILE		78	−21.364	29.560	−74.537	1.00	36.94	O
ATOM	502	N	THR		79	−22.101	31.616	−75.067	1.00	38.09	N
ATOM	503	CA	THR		79	−21.920	32.144	−73.718	1.00	39.79	C
ATOM	504	CB	THR		79	−21.096	33.439	−73.755	1.00	39.64	C
ATOM	505	OG1	THR		79	−21.719	34.378	−74.639	1.00	41.79	O
ATOM	506	CG2	THR		79	−19.691	33.153	−74.245	1.00	42.02	C
ATOM	507	C	THR		79	−23.200	32.421	−72.918	1.00	39.96	C
ATOM	508	O	THR		79	−23.148	32.559	−71.693	1.00	39.73	O
ATOM	509	N	ARG		80	−24.344	32.508	−73.594	1.00	38.62	N
ATOM	510	CA	ARG		80	−25.595	32.781	−72.890	1.00	35.82	C
ATOM	511	CB	ARG		80	−26.777	32.799	−73.871	1.00	35.18	C
ATOM	512	CG	ARG		80	−27.144	31.441	−74.469	1.00	34.17	C
ATOM	513	CD	ARG		80	−28.436	31.533	−75.276	1.00	31.28	C
ATOM	514	NE	ARG		80	−28.258	32.229	−76.548	1.00	28.97	N
ATOM	515	CZ	ARG		80	−27.875	31.637	−77.676	1.00	28.79	C
ATOM	516	NH1	ARG		80	−27.634	30.330	−77.690	1.00	27.36	N
ATOM	517	NH2	ARG		80	−27.737	32.344	−78.789	1.00	27.52	N
ATOM	518	C	ARG		80	−25.850	31.754	−71.790	1.00	34.96	C
ATOM	519	O	ARG		80	−25.455	30.593	−71.905	1.00	33.89	O
ATOM	520	N	THR		81	−26.506	32.190	−70.717	1.00	35.04	N
ATOM	521	CA	THR		81	−26.821	31.310	−69.594	1.00	35.19	C
ATOM	522	CB	THR		81	−27.054	32.130	−68.311	1.00	36.24	C
ATOM	523	OG1	THR		81	−28.244	32.924	−68.456	1.00	38.15	O
ATOM	524	CG2	THR		81	−25.874	33.056	−68.054	1.00	37.03	C
ATOM	525	C	THR		81	−28.086	30.503	−69.891	1.00	34.54	C
ATOM	526	O	THR		81	−28.806	30.813	−70.839	1.00	33.46	O
ATOM	527	N	LYS		82	−28.357	29.472	−69.089	1.00	34.65	N
ATOM	528	CA	LYS		82	−29.559	28.657	−69.280	1.00	36.61	C
ATOM	529	CB	LYS		82	−29.697	27.585	−68.197	1.00	39.22	C
ATOM	530	CG	LYS		82	−28.609	26.542	−68.162	1.00	44.85	C
ATOM	531	CD	LYS		82	−29.042	25.344	−67.316	1.00	48.00	C
ATOM	532	CE	LYS		82	−29.418	25.752	−65.894	1.00	50.16	C
ATOM	533	NZ	LYS		82	−29.850	24.579	−65.075	1.00	51.59	N
ATOM	534	C	LYS		82	−30.793	29.540	−69.194	1.00	36.39	C
ATOM	535	O	LYS		82	−31.766	29.345	−69.922	1.00	36.10	O
ATOM	536	N	GLU		83	−30.748	30.496	−68.276	1.00	35.53	N
ATOM	537	CA	GLU		83	−31.860	31.407	−68.062	1.00	35.08	C
ATOM	538	CB	GLU		83	−31.589	32.277	−66.827	1.00	36.60	C
ATOM	539	CG	GLU		83	−31.600	31.494	−65.507	1.00	38.74	C
ATOM	540	CD	GLU		83	−30.382	30.586	−65.320	1.00	40.94	C
ATOM	541	OE1	GLU		83	−30.505	29.566	−64.603	1.00	42.51	O
ATOM	542	OE2	GLU		83	−29.300	30.896	−65.867	1.00	40.30	O
ATOM	543	C	GLU		83	−32.127	32.278	−69.282	1.00	33.29	C
ATOM	544	O	GLU		83	−33.282	32.503	−69.647	1.00	31.45	O
ATOM	545	N	GLU		84	−31.068	32.769	−69.913	1.00	33.06	N
ATOM	546	CA	GLU		84	−31.227	33.607	−71.099	1.00	32.42	C
ATOM	547	CB	GLU		84	−29.898	34.254	−71.478	1.00	34.53	C
ATOM	548	CG	GLU		84	−29.322	35.141	−70.392	1.00	38.11	C
ATOM	549	CD	GLU		84	−27.951	35.669	−70.750	1.00	38.58	C
ATOM	550	OE1	GLU		84	−27.067	34.849	−71.078	1.00	40.41	O
ATOM	551	OE2	GLU		84	−27.755	36.902	−70.701	1.00	39.09	O
ATOM	552	C	GLU		84	−31.735	32.757	−72.256	1.00	31.30	C
ATOM	553	O	GLU		84	−32.508	33.226	−73.091	1.00	29.28	O
ATOM	554	N	ALA		85	−31.292	31.505	−72.295	1.00	29.62	N
ATOM	555	CA	ALA		85	−31.704	30.571	−73.333	1.00	28.65	C
ATOM	556	CB	ALA		85	−30.912	29.273	−73.210	1.00	29.16	C
ATOM	557	C	ALA		85	−33.197	30.286	−73.198	1.00	28.26	C
ATOM	558	O	ALA		85	−33.924	30.248	−74.192	1.00	25.90	O
ATOM	559	N	LEU		86	−33.652	30.078	−71.965	1.00	26.44	N
ATOM	560	CA	LEU		86	−35.066	29.801	−71.731	1.00	27.63	C
ATOM	561	CB	LEU		86	−35.316	29.446	−70.261	1.00	25.67	C
ATOM	562	CG	LEU		86	−36.772	29.120	−69.885	1.00	26.59	C
ATOM	563	CD1	LEU		86	−37.312	28.003	−70.777	1.00	23.47	C
ATOM	564	CD2	LEU		86	−36.844	28.707	−68.422	1.00	25.60	C
ATOM	565	C	LEU		86	−35.920	31.003	−72.130	1.00	26.37	C
ATOM	566	O	LEU		86	−37.036	30.839	−72.621	1.00	25.81	O
ATOM	567	N	GLU		87	−35.396	32.212	−71.926	1.00	27.04	N
ATOM	568	CA	GLU		87	−36.144	33.408	−72.297	1.00	29.41	C
ATOM	569	CB	GLU		87	−35.503	34.666	−71.702	1.00	32.96	C
ATOM	570	CG	GLU		87	−35.826	34.831	−70.228	1.00	40.07	C
ATOM	571	CD	GLU		87	−37.314	34.610	−69.941	1.00	44.94	C
ATOM	572	OE1	GLU		87	−38.144	35.414	−70.425	1.00	46.00	O
ATOM	573	OE2	GLU		87	−37.652	33.627	−69.240	1.00	47.31	O
ATOM	574	C	GLU		87	−36.276	33.545	−73.806	1.00	28.57	C
ATOM	575	O	GLU		87	−37.298	34.025	−74.302	1.00	27.18	O
ATOM	576	N	LEU		88	−35.240	33.139	−74.530	1.00	26.02	N
ATOM	577	CA	LEU		88	−35.265	33.184	−75.985	1.00	24.59	C
ATOM	578	CB	LEU		88	−33.890	32.836	−76.555	1.00	25.51	C
ATOM	579	CG	LEU		88	−32.819	33.927	−76.454	1.00	26.64	C
ATOM	580	CD1	LEU		88	−31.449	33.351	−76.812	1.00	25.81	C
ATOM	581	CD2	LEU		88	−33.192	35.080	−77.379	1.00	26.30	C
ATOM	582	C	LEU		88	−36.295	32.162	−76.463	1.00	23.40	C
ATOM	583	O	LEU		88	−37.129	32.463	−77.316	1.00	24.39	O
ATOM	584	N	ILE		89	−36.228	30.958	−75.905	1.00	20.40	N
ATOM	585	CA	ILE		89	−37.156	29.889	−76.257	1.00	21.30	C
ATOM	586	CB	ILE		89	−36.861	28.600	−75.437	1.00	20.83	C
ATOM	587	CG2	ILE		89	−38.087	27.697	−75.406	1.00	19.00	C
ATOM	588	CG1	ILE		89	−35.671	27.842	−76.042	1.00	18.75	C
ATOM	589	CD1	ILE		89	−36.017	27.018	−77.298	1.00	17.72	C
ATOM	590	C	ILE		89	−38.586	30.352	−75.990	1.00	22.69	C
ATOM	591	O	ILE		89	−39.467	30.170	−76.830	1.00	24.07	O
ATOM	592	N	ASN		90	−38.819	30.959	−74.827	1.00	23.22	N
ATOM	593	CA	ASN		90	−40.161	31.429	−74.493	1.00	22.69	C
ATOM	594	CB	ASN		90	−40.215	32.012	−73.077	1.00	23.78	C
ATOM	595	CG	ASN		90	−40.123	30.942	−71.995	1.00	24.09	C
ATOM	596	OD1	ASN		90	−40.502	29.790	−72.208	1.00	25.66	O
ATOM	597	ND2	ASN		90	−39.641	31.332	−70.822	1.00	25.94	N
ATOM	598	C	ASN		90	−40.626	32.476	−75.496	1.00	22.56	C
ATOM	599	O	ASN		90	−41.798	32.493	−75.880	1.00	22.81	O
ATOM	600	N	GLY		91	−39.708	33.344	−75.920	1.00	22.08	N
ATOM	601	CA	GLY		91	−40.045	34.369	−76.893	1.00	21.04	C
ATOM	602	C	GLY		91	−40.428	33.775	−78.240	1.00	22.57	C
ATOM	603	O	GLY		91	−41.375	34.234	−78.890	1.00	23.12	O
ATOM	604	N	TYR		92	−39.695	32.748	−78.671	1.00	21.06	N
ATOM	605	CA	TYR		92	−39.973	32.095	−79.945	1.00	19.79	C
ATOM	606	CB	TYR		92	−38.895	31.053	−80.268	1.00	20.25	C
ATOM	607	CG	TYR		92	−37.502	31.621	−80.494	1.00	22.09	C
ATOM	608	CD1	TYR		92	−36.372	30.897	−80.120	1.00	22.58	C
ATOM	609	CE1	TYR		92	−35.092	31.403	−80.308	1.00	24.75	C
ATOM	610	CD2	TYR		92	−37.315	32.874	−81.071	1.00	22.30	C
ATOM	611	CE2	TYR		92	−36.029	33.393	−81.266	1.00	24.63	C
ATOM	612	CZ	TYR		92	−34.926	32.647	−80.876	1.00	24.91	C
ATOM	613	OH	TYR		92	−33.651	33.150	−81.030	1.00	28.01	O
ATOM	614	C	TYR		92	−41.334	31.408	−79.899	1.00	18.33	C
ATOM	615	O	TYR		92	−42.065	31.421	−80.880	1.00	18.35	O
ATOM	616	N	ILE		93	−41.668	30.806	−78.760	1.00	18.81	N
ATOM	617	CA	ILE		93	−42.948	30.116	−78.609	1.00	19.17	C
ATOM	618	CB	ILE		93	−43.036	29.381	−77.247	1.00	19.71	C
ATOM	619	CG2	ILE		93	−44.472	28.921	−76.981	1.00	17.96	C
ATOM	620	CG1	ILE		93	−42.099	28.167	−77.246	1.00	18.40	C
ATOM	621	CD1	ILE		93	−42.116	27.401	−75.936	1.00	19.85	C
ATOM	622	C	ILE		93	−44.091	31.126	−78.712	1.00	20.54	C
ATOM	623	O	ILE		93	−45.125	30.857	−79.327	1.00	20.59	O
ATOM	624	N	GLN		94	−43.895	32.292	−78.109	1.00	20.79	N
ATOM	625	CA	GLN		94	−44.904	33.338	−78.150	1.00	23.15	C
ATOM	626	CB	GLN		94	−44.467	34.535	−77.301	1.00	24.71	C
ATOM	627	CG	GLN		94	−44.469	34.247	−75.811	1.00	28.57	C
ATOM	628	CD	GLN		94	−44.353	35.504	−74.981	1.00	33.05	C
ATOM	629	OE1	GLN		94	−43.352	36.213	−75.044	1.00	35.55	O
ATOM	630	NE2	GLN		94	−45.386	35.789	−74.201	1.00	36.40	N
ATOM	631	C	GLN		94	−45.167	33.792	−79.581	1.00	23.38	C
ATOM	632	O	GLN		94	−46.322	33.935	−79.994	1.00	23.82	O
ATOM	633	N	LYS		95	−44.097	34.012	−80.336	1.00	23.21	N
ATOM	634	CA	LYS		95	−44.220	34.454	−81.719	1.00	24.19	C
ATOM	635	CB	LYS		95	−42.847	34.887	−82.246	1.00	28.16	C
ATOM	636	CG	LYS		95	−42.427	36.265	−81.733	1.00	34.00	C
ATOM	637	CD	LYS		95	−40.944	36.570	−81.949	1.00	39.23	C
ATOM	638	CE	LYS		95	−40.070	35.856	−80.911	1.00	43.92	C
ATOM	639	NZ	LYS		95	−38.651	36.344	−80.864	1.00	42.61	N
ATOM	640	C	LYS		95	−44.840	33.384	−82.619	1.00	22.76	C
ATOM	641	O	LYS		95	−45.509	33.695	−83.601	1.00	20.97	O
ATOM	642	N	ILE		96	−44.618	32.118	−82.286	1.00	20.58	N
ATOM	643	CA	ILE		96	−45.190	31.035	−83.080	1.00	20.56	C
ATOM	644	CB	ILE		96	−44.504	29.689	−82.750	1.00	18.89	C
ATOM	645	CG2	ILE		96	−45.295	28.522	−83.342	1.00	18.25	C
ATOM	646	CG1	ILE		96	−43.063	29.712	−83.270	1.00	18.81	C
ATOM	647	CD1	ILE		96	−42.230	28.495	−82.866	1.00	21.84	C
ATOM	648	C	ILE		96	−46.689	30.942	−82.784	1.00	19.80	C
ATOM	649	O	ILE		96	−47.517	30.847	−83.697	1.00	19.75	O
ATOM	650	N	LYS		97	−47.036	30.986	−81.505	1.00	19.01	N
ATOM	651	CA	LYS		97	−48.436	30.903	−81.093	1.00	20.09	C
ATOM	652	CB	LYS		97	−48.544	30.769	−79.574	1.00	20.11	C
ATOM	653	CG	LYS		97	−48.196	29.394	−79.053	1.00	22.03	C
ATOM	654	CD	LYS		97	−48.661	29.217	−77.616	1.00	22.66	C
ATOM	655	CE	LYS		97	−48.440	27.781	−77.169	1.00	23.25	C
ATOM	656	NZ	LYS		97	−49.076	27.472	−75.860	1.00	22.54	N
ATOM	657	C	LYS		97	−49.279	32.092	−81.543	1.00	19.51	C
ATOM	658	O	LYS		97	−50.478	31.952	−81.785	1.00	19.03	O
ATOM	659	N	SER		98	−48.660	33.261	−81.647	1.00	19.97	N
ATOM	660	CA	SER		98	−49.381	34.459	−82.071	1.00	21.29	C
ATOM	661	CB	SER		98	−48.656	35.713	−81.587	1.00	20.80	C
ATOM	662	OG	SER		98	−47.423	35.857	−82.265	1.00	24.27	O
ATOM	663	C	SER		98	−49.489	34.506	−83.588	1.00	22.65	C
ATOM	664	O	SER		98	−50.297	35.255	−84.144	1.00	22.70	O
ATOM	665	N	GLY		99	−48.668	33.705	−84.262	1.00	22.03	N
ATOM	666	CA	GLY		99	−48.689	33.689	−85.710	1.00	22.11	C
ATOM	667	C	GLY		99	−47.780	34.740	−86.321	1.00	24.34	C
ATOM	668	O	GLY		99	−47.726	34.880	−87.541	1.00	22.82	O
ATOM	669	N	GLU		100	−47.069	35.488	−85.476	1.00	25.40	N
ATOM	670	CA	GLU		100	−46.153	36.528	−85.947	1.00	28.95	C
ATOM	671	CB	GLU		100	−45.551	37.283	−84.759	1.00	32.53	C
ATOM	672	CG	GLU		100	−46.540	38.194	−84.026	1.00	41.15	C
ATOM	673	CD	GLU		100	−45.934	38.857	−82.789	1.00	44.77	C
ATOM	674	OE1	GLU		100	−45.741	38.169	−81.762	1.00	46.13	O
ATOM	675	OE2	GLU		100	−45.647	40.073	−82.848	1.00	49.70	O
ATOM	676	C	GLU		100	−45.031	35.923	−86.783	1.00	29.40	C
ATOM	677	O	GLU		100	−44.581	36.509	−87.768	1.00	28.16	O
ATOM	678	N	GLU		101	−44.592	34.737	−86.378	1.00	28.86	N
ATOM	679	CA	GLU		101	−43.523	34.017	−87.055	1.00	30.92	C
ATOM	680	CB	GLU		101	−42.198	34.254	−86.328	1.00	35.00	C
ATOM	681	CG	GLU		101	−41.529	35.573	−86.639	1.00	41.45	C
ATOM	682	CD	GLU		101	−40.756	35.515	−87.935	1.00	44.31	C
ATOM	683	OE1	GLU		101	−41.382	35.274	−88.989	1.00	48.34	O
ATOM	684	OE2	GLU		101	−39.521	35.700	−87.901	1.00	47.67	O
ATOM	685	C	GLU		101	−43.859	32.536	−87.000	1.00	30.84	C
ATOM	686	O	GLU		101	−44.427	32.066	−86.014	1.00	30.96	O
ATOM	687	N	ASP		102	−43.532	31.785	−88.045	1.00	28.18	N
ATOM	688	CA	ASP		102	−43.825	30.369	−87.967	1.00	29.28	C
ATOM	689	CB	ASP		102	−44.466	29.849	−89.265	1.00	33.40	C
ATOM	690	CG	ASP		102	−43.661	30.160	−90.489	1.00	37.39	C
ATOM	691	OD1	ASP		102	−44.247	30.119	−91.598	1.00	38.22	O
ATOM	692	OD2	ASP		102	−42.451	30.435	−90.350	1.00	41.69	O
ATOM	693	C	ASP		102	−42.585	29.570	−87.571	1.00	26.83	C
ATOM	694	O	ASP		102	−41.449	30.016	−87.740	1.00	24.79	O
ATOM	695	N	PHE		103	−42.831	28.409	−86.993	1.00	24.22	N
ATOM	696	CA	PHE		103	−41.784	27.526	−86.514	1.00	24.56	C
ATOM	697	CB	PHE		103	−42.391	26.157	−86.202	1.00	25.53	C
ATOM	698	CG	PHE		103	−41.408	25.187	−85.632	1.00	27.92	C
ATOM	699	CD1	PHE		103	−41.200	25.118	−84.262	1.00	29.19	C
ATOM	700	CD2	PHE		103	−40.638	24.392	−86.468	1.00	29.19	C
ATOM	701	CE1	PHE		103	−40.241	24.272	−83.737	1.00	28.53	C
ATOM	702	CE2	PHE		103	−39.678	23.546	−85.949	1.00	29.70	C
ATOM	703	CZ	PHE		103	−39.479	23.488	−84.581	1.00	29.29	C
ATOM	704	C	PHE		103	−40.587	27.344	−87.452	1.00	23.64	C
ATOM	705	O	PHE		103	−39.433	27.528	−87.051	1.00	22.12	O
ATOM	706	N	GLU		104	−40.868	26.964	−88.692	1.00	23.35	N
ATOM	707	CA	GLU		104	−39.820	26.713	−89.682	1.00	24.68	C
ATOM	708	CB	GLU		104	−40.446	26.321	−91.027	1.00	24.58	C
ATOM	709	CG	GLU		104	−41.215	25.017	−90.988	1.00	24.92	C
ATOM	710	CD	GLU		104	−42.664	25.201	−90.592	1.00	27.46	C
ATOM	711	OE1	GLU		104	−43.004	26.236	−89.965	1.00	22.43	O
ATOM	712	OE2	GLU		104	−43.462	24.296	−90.910	1.00	30.49	O
ATOM	713	C	GLU		104	−38.882	27.888	−89.887	1.00	24.17	C
ATOM	714	O	GLU		104	−37.665	27.714	−90.027	1.00	24.38	O
ATOM	715	N	SER		105	−39.460	29.085	−89.903	1.00	23.52	N
ATOM	716	CA	SER		105	−38.704	30.310	−90.095	1.00	23.54	C
ATOM	717	CB	SER		105	−39.674	31.483	−90.242	1.00	25.75	C
ATOM	718	OG	SER		105	−38.983	32.704	−90.361	1.00	27.97	O
ATOM	719	C	SER		105	−37.724	30.583	−88.950	1.00	22.93	C
ATOM	720	O	SER		105	−36.550	30.882	−89.180	1.00	23.53	O
ATOM	721	N	LEU		106	−38.206	30.485	−87.715	1.00	22.10	N
ATOM	722	CA	LEU		106	−37.366	30.729	−86.544	1.00	21.00	C
ATOM	723	CB	LEU		106	−38.231	30.813	−85.281	1.00	19.48	C
ATOM	724	CG	LEU		106	−39.255	31.951	−85.272	1.00	20.14	C
ATOM	725	CD1	LEU		106	−40.108	31.889	−84.001	1.00	17.01	C
ATOM	726	CD2	LEU		106	−38.517	33.285	−85.363	1.00	17.02	C
ATOM	727	C	LEU		106	−36.304	29.646	−86.374	1.00	19.92	C
ATOM	728	O	LEU		106	−35.207	29.918	−85.892	1.00	18.98	O
ATOM	729	N	ALA		107	−36.630	28.420	−86.765	1.00	19.37	N
ATOM	730	CA	ALA		107	−35.682	27.312	−86.655	1.00	20.71	C
ATOM	731	CB	ALA		107	−36.382	25.995	−86.948	1.00	17.40	C
ATOM	732	C	ALA		107	−34.511	27.503	−87.618	1.00	20.55	C
ATOM	733	O	ALA		107	−33.353	27.298	−87.251	1.00	20.24	O
ATOM	734	N	SER		108	−34.820	27.888	−88.851	1.00	20.75	N
ATOM	735	CA	SER		108	−33.799	28.115	−89.868	1.00	21.17	C
ATOM	736	CB	SER		108	−34.446	28.521	−91.194	1.00	21.17	C
ATOM	737	OG	SER		108	−35.204	27.457	−91.740	1.00	26.99	O
ATOM	738	C	SER		108	−32.867	29.237	−89.428	1.00	22.83	C
ATOM	739	O	SER		108	−31.657	29.197	−89.662	1.00	22.76	O
ATOM	740	N	GLN		109	−33.457	30.239	−88.795	1.00	23.07	N
ATOM	741	CA	GLN		109	−32.729	31.410	−88.336	1.00	24.82	C
ATOM	742	CB	GLN		109	−33.686	32.596	−88.224	1.00	26.15	C
ATOM	743	CG	GLN		109	−34.057	33.260	−89.526	1.00	27.56	C
ATOM	744	CD	GLN		109	−35.099	34.338	−89.328	1.00	28.78	C
ATOM	745	OE1	GLN		109	−36.304	34.071	−89.360	1.00	32.49	O
ATOM	746	NE2	GLN		109	−34.644	35.562	−89.100	1.00	28.95	N
ATOM	747	C	GLN		109	−31.999	31.293	−87.011	1.00	24.67	C
ATOM	748	O	GLN		109	−30.868	31.751	−86.886	1.00	24.49	O
ATOM	749	N	PHE		110	−32.634	30.671	−86.024	1.00	24.93	N
ATOM	750	CA	PHE		110	−32.043	30.636	−84.697	1.00	24.35	C
ATOM	751	CB	PHE		110	−32.942	31.462	−83.763	1.00	24.01	C
ATOM	752	CG	PHE		110	−33.304	32.821	−84.326	1.00	24.93	C
ATOM	753	CD1	PHE		110	−34.613	33.117	−84.683	1.00	25.09	C
ATOM	754	CD2	PHE		110	−32.324	33.787	−84.530	1.00	26.39	C
ATOM	755	CE1	PHE		110	−34.947	34.354	−85.239	1.00	25.11	C
ATOM	756	CE2	PHE		110	−32.644	35.030	−85.087	1.00	26.05	C
ATOM	757	CZ	PHE		110	−33.961	35.315	−85.442	1.00	26.01	C
ATOM	758	C	PHE		110	−31.686	29.320	−84.018	1.00	23.51	C
ATOM	759	O	PHE		110	−31.101	29.338	−82.939	1.00	25.94	O
ATOM	760	N	SER		111	−32.011	28.184	−84.617	1.00	22.88	N
ATOM	761	CA	SER		111	−31.687	26.921	−83.969	1.00	22.83	C
ATOM	762	CB	SER		111	−32.401	25.768	−84.656	1.00	20.14	C
ATOM	763	OG	SER		111	−32.137	24.561	−83.968	1.00	22.59	O
ATOM	764	C	SER		111	−30.185	26.642	−83.951	1.00	24.68	C
ATOM	765	O	SER		111	−29.515	26.765	−84.974	1.00	22.64	O
ATOM	766	N	ASP		112	−29.667	26.262	−82.783	1.00	25.44	N
ATOM	767	CA	ASP		112	−28.244	25.964	−82.631	1.00	26.82	C
ATOM	768	CB	ASP		112	−27.791	26.208	−81.186	1.00	24.69	C
ATOM	769	CG	ASP		112	−27.570	27.680	−80.887	1.00	25.32	C
ATOM	770	OD1	ASP		112	−26.863	28.340	−81.675	1.00	23.55	O
ATOM	771	OD2	ASP		112	−28.088	28.179	−79.864	1.00	25.17	O
ATOM	772	C	ASP		112	−27.899	24.536	−83.030	1.00	27.96	C
ATOM	773	O	ASP		112	−26.989	23.931	−82.473	1.00	30.66	O
ATOM	774	N	CYS		113	−28.633	24.004	−84.002	1.00	28.66	N
ATOM	775	CA	CYS		113	−28.398	22.655	−84.495	1.00	28.76	C
ATOM	776	CB	CYS		113	−29.511	21.726	−84.021	1.00	28.26	C
ATOM	777	SG	CYS		113	−29.415	20.057	−84.682	1.00	36.66	S
ATOM	778	C	CYS		113	−28.373	22.717	−86.016	1.00	27.51	C
ATOM	779	O	CYS		113	−29.103	23.503	−86.615	1.00	29.37	O
ATOM	780	N	SER		114	−27.529	21.901	−86.641	1.00	25.10	N
ATOM	781	CA	SER		114	−27.428	21.901	−88.097	1.00	25.86	C
ATOM	782	CB	SER		114	−26.321	20.940	−88.562	1.00	26.12	C
ATOM	783	OG	SER		114	−26.490	19.645	−88.009	1.00	32.53	O
ATOM	784	C	SER		114	−28.752	21.544	−88.768	1.00	24.32	C
ATOM	785	O	SER		114	−28.940	21.802	−89.958	1.00	24.25	O
ATOM	786	N	SER		115	−29.671	20.955	−88.005	1.00	23.86	N
ATOM	787	CA	SER		115	−30.980	20.593	−88.545	1.00	23.37	C
ATOM	788	CB	SER		115	−31.797	19.822	−87.504	1.00	24.93	C
ATOM	789	OG	SER		115	−31.954	20.577	−86.318	1.00	26.09	O
ATOM	790	C	SER		115	−31.713	21.868	−88.950	1.00	22.22	C
ATOM	791	O	SER		115	−32.768	21.825	−89.583	1.00	21.06	O
ATOM	792	N	ALA		116	−31.136	23.004	−88.577	1.00	20.37	N
ATOM	793	CA	ALA		116	−31.701	24.303	−88.911	1.00	20.24	C
ATOM	794	CB	ALA		116	−30.862	25.415	−88.277	1.00	21.48	C
ATOM	795	C	ALA		116	−31.748	24.493	−90.434	1.00	22.31	C
ATOM	796	O	ALA		116	−32.649	25.158	−90.957	1.00	20.99	O
ATOM	797	N	LYS		117	−30.781	23.909	−91.138	1.00	20.32	N
ATOM	798	CA	LYS		117	−30.715	24.048	−92.593	1.00	22.01	C
ATOM	799	CB	LYS		117	−29.373	23.532	−93.126	1.00	25.14	C
ATOM	800	CG	LYS		117	−28.166	24.091	−92.404	1.00	28.67	C
ATOM	801	CD	LYS		117	−28.207	25.606	−92.338	1.00	31.87	C
ATOM	802	CE	LYS		117	−27.120	26.139	−91.407	1.00	34.51	C
ATOM	803	NZ	LYS		117	−27.237	27.606	−91.187	1.00	34.85	N
ATOM	804	C	LYS		117	−31.858	23.321	−93.290	1.00	21.29	C
ATOM	805	O	LYS		117	−32.096	23.522	−94.481	1.00	20.12	O
ATOM	806	N	ALA		118	−32.550	22.470	−92.537	1.00	21.37	N
ATOM	807	CA	ALA		118	−33.688	21.716	−93.053	1.00	22.04	C
ATOM	808	CB	ALA		118	−33.491	20.227	−92.800	1.00	22.43	C
ATOM	809	C	ALA		118	−34.944	22.203	−92.337	1.00	21.60	C
ATOM	810	O	ALA		118	−35.854	21.423	−92.060	1.00	20.00	O
ATOM	811	N	ARG		119	−34.971	23.496	−92.028	1.00	22.99	N
ATOM	812	CA	ARG		119	−36.100	24.110	−91.336	1.00	24.09	C
ATOM	813	CB	ARG		119	−37.348	24.102	−92.228	1.00	26.58	C
ATOM	814	CG	ARG		119	−37.172	24.805	−93.570	1.00	30.16	C
ATOM	815	CD	ARG		119	−38.498	24.876	−94.337	1.00	33.21	C
ATOM	816	NE	ARG		119	−39.152	23.570	−94.366	1.00	38.79	N
ATOM	817	CZ	ARG		119	−40.456	23.375	−94.576	1.00	39.14	C
ATOM	818	NH1	ARG		119	−41.273	24.405	−94.784	1.00	36.88	N
ATOM	819	NH2	ARG		119	−40.945	22.140	−94.553	1.00	38.74	N
ATOM	820	C	ARG		119	−36.393	23.380	−90.030	1.00	24.50	C
ATOM	821	O	ARG		119	−37.540	23.324	−89.578	1.00	21.47	O
ATOM	822	N	GLY		120	−35.344	22.814	−89.432	1.00	22.49	N
ATOM	823	CA	GLY		120	−35.491	22.116	−88.168	1.00	22.55	C
ATOM	824	C	GLY		120	−35.872	20.652	−88.236	1.00	22.32	C
ATOM	825	O	GLY		120	−35.942	19.989	−87.202	1.00	22.89	O
ATOM	826	N	ASP		121	−36.106	20.136	−89.439	1.00	21.83	N
ATOM	827	CA	ASP		121	−36.494	18.733	−89.602	1.00	22.77	C
ATOM	828	CB	ASP		121	−36.934	18.478	−91.052	1.00	22.05	C
ATOM	829	CG	ASP		121	−37.315	17.024	−91.302	1.00	23.31	C
ATOM	830	OD1	ASP		121	−38.017	16.435	−90.455	1.00	22.45	O
ATOM	831	OD2	ASP		121	−36.926	16.472	−92.352	1.00	22.47	O
ATOM	832	C	ASP		121	−35.378	17.757	−89.220	1.00	23.21	C
ATOM	833	O	ASP		121	−34.233	17.915	−89.644	1.00	22.01	O
ATOM	834	N	LEU		122	−35.724	16.760	−88.409	1.00	22.66	N
ATOM	835	CA	LEU		122	−34.775	15.733	−87.976	1.00	25.01	C
ATOM	836	CB	LEU		122	−34.839	15.549	−86.461	1.00	24.51	C
ATOM	837	CG	LEU		122	−34.212	16.655	−85.618	1.00	25.76	C
ATOM	838	CD1	LEU		122	−34.657	16.509	−84.169	1.00	25.46	C
ATOM	839	CD2	LEU		122	−32.700	16.585	−85.739	1.00	25.27	C
ATOM	840	C	LEU		122	−35.100	14.404	−88.638	1.00	25.23	C
ATOM	841	O	LEU		122	−34.369	13.430	−88.477	1.00	25.59	O
ATOM	842	N	GLY		123	−36.200	14.371	−89.384	1.00	25.89	N
ATOM	843	CA	GLY		123	−36.606	13.143	−90.036	1.00	24.99	C
ATOM	844	C	GLY		123	−37.362	12.276	−89.055	1.00	26.47	C
ATOM	845	O	GLY		123	−37.696	12.724	−87.949	1.00	26.25	O
ATOM	846	N	ALA		124	−37.638	11.037	−89.451	1.00	26.84	N
ATOM	847	CA	ALA		124	−38.363	10.102	−88.599	1.00	29.44	C
ATOM	848	CB	ALA		124	−39.169	9.132	−89.455	1.00	29.71	C
ATOM	849	C	ALA		124	−37.406	9.330	−87.695	1.00	31.97	C
ATOM	850	O	ALA		124	−36.233	9.141	−88.025	1.00	33.44	O
ATOM	851	N	PHE		125	−37.912	8.883	−86.550	1.00	32.29	N
ATOM	852	CA	PHE		125	−37.099	8.130	−85.604	1.00	32.91	C
ATOM	853	CB	PHE		125	−36.170	9.079	−84.827	1.00	32.38	C
ATOM	854	CG	PHE		125	−36.889	10.195	−84.090	1.00	33.81	C
ATOM	855	CD1	PHE		125	−37.404	9.993	−82.815	1.00	33.23	C
ATOM	856	CD2	PHE		125	−37.029	11.453	−84.671	1.00	33.83	C
ATOM	857	CE1	PHE		125	−38.046	11.025	−82.126	1.00	32.81	C
ATOM	858	CE2	PHE		125	−37.671	12.493	−83.991	1.00	33.48	C
ATOM	859	CZ	PHE		125	−38.179	12.277	−82.713	1.00	33.57	C
ATOM	860	C	PHE		125	−37.965	7.324	−84.651	1.00	33.85	C
ATOM	861	O	PHE		125	−39.153	7.607	−84.482	1.00	33.96	O
ATOM	862	N	SER		126	−37.368	6.303	−84.046	1.00	34.41	N
ATOM	863	CA	SER		126	−38.077	5.454	−83.095	1.00	35.67	C
ATOM	864	CB	SER		126	−37.926	3.974	−83.480	1.00	37.06	C
ATOM	865	OG	SER		126	−36.566	3.571	−83.424	1.00	37.60	O
ATOM	866	C	SER		126	−37.480	5.689	−81.712	1.00	34.93	C
ATOM	867	O	SER		126	−36.532	6.463	−81.565	1.00	34.78	O
ATOM	868	N	ARG		127	−38.037	5.037	−80.698	1.00	35.72	N
ATOM	869	CA	ARG		127	−37.516	5.196	−79.349	1.00	37.20	C
ATOM	870	CB	ARG		127	−38.449	4.552	−78.326	1.00	35.34	C
ATOM	871	CG	ARG		127	−39.688	5.376	−78.027	1.00	36.16	C
ATOM	872	CD	ARG		127	−40.505	4.726	−76.941	1.00	34.47	C
ATOM	873	NE	ARG		127	−41.695	5.494	−76.598	1.00	33.99	N
ATOM	874	CZ	ARG		127	−41.699	6.602	−75.863	1.00	30.76	C
ATOM	875	NH1	ARG		127	−40.567	7.097	−75.380	1.00	28.17	N
ATOM	876	NH2	ARG		127	−42.852	7.207	−75.600	1.00	30.41	N
ATOM	877	C	ARG		127	−36.131	4.572	−79.247	1.00	39.06	C
ATOM	878	O	ARG		127	−35.862	3.531	−79.849	1.00	39.54	O
ATOM	879	N	GLY		128	−35.252	5.226	−78.497	1.00	39.85	N
ATOM	880	CA	GLY		128	−33.905	4.716	−78.322	1.00	40.80	C
ATOM	881	C	GLY		128	−32.859	5.390	−79.186	1.00	40.23	C
ATOM	882	O	GLY		128	−31.697	4.988	−79.168	1.00	42.50	O
ATOM	883	N	GLN		129	−33.250	6.416	−79.938	1.00	39.06	N
ATOM	884	CA	GLN		129	−32.304	7.108	−80.805	1.00	37.01	C
ATOM	885	CB	GLN		129	−32.859	7.217	−82.225	1.00	38.65	C
ATOM	886	CG	GLN		129	−33.359	5.909	−82.820	1.00	40.19	C
ATOM	887	CD	GLN		129	−33.827	6.076	−84.256	1.00	40.77	C
ATOM	888	OE1	GLN		129	−34.557	5.239	−84.788	1.00	42.20	O
ATOM	889	NE2	GLN		129	−33.399	7.158	−84.894	1.00	42.66	N
ATOM	890	C	GLN		129	−31.941	8.501	−80.320	1.00	36.26	C
ATOM	891	O	GLN		129	−30.781	8.893	−80.372	1.00	35.91	O
ATOM	892	N	MET		130	−32.932	9.253	−79.854	1.00	34.08	N
ATOM	893	CA	MET		130	−32.691	10.617	−79.392	1.00	33.69	C
ATOM	894	CB	MET		130	−33.859	11.521	−79.805	1.00	35.18	C
ATOM	895	CG	MET		130	−34.250	11.427	−81.272	1.00	35.18	C
ATOM	896	SD	MET		130	−33.007	12.146	−82.338	1.00	37.15	S
ATOM	897	CE	MET		130	−33.806	12.029	−83.934	1.00	36.44	C
ATOM	898	C	MET		130	−32.526	10.701	−77.880	1.00	31.67	C
ATOM	899	O	MET		130	−32.866	9.772	−77.153	1.00	32.91	O
ATOM	900	N	GLN		131	−31.991	11.823	−77.411	1.00	31.48	N
ATOM	901	CA	GLN		131	−31.836	12.044	−75.982	1.00	32.27	C
ATOM	902	CB	GLN		131	−31.345	13.467	−75.734	1.00	32.97	C
ATOM	903	CG	GLN		131	−29.901	13.673	−76.145	1.00	34.90	C
ATOM	904	CD	GLN		131	−29.493	15.128	−76.147	1.00	36.75	C
ATOM	905	OE1	GLN		131	−28.345	15.463	−75.856	1.00	38.84	O
ATOM	906	NE2	GLN		131	−30.430	16.004	−76.496	1.00	36.93	N
ATOM	907	C	GLN		131	−33.218	11.830	−75.366	1.00	32.66	C
ATOM	908	O	GLN		131	−34.225	12.343	−75.875	1.00	32.82	O
ATOM	909	N	LYS		132	−33.259	11.067	−74.279	1.00	30.69	N
ATOM	910	CA	LYS		132	−34.500	10.710	−73.590	1.00	29.26	C
ATOM	911	CB	LYS		132	−34.156	10.100	−72.227	1.00	28.95	C
ATOM	912	CG	LYS		132	−35.306	9.342	−71.594	1.00	29.31	C
ATOM	913	CD	LYS		132	−35.843	8.279	−72.536	1.00	26.37	C
ATOM	914	CE	LYS		132	−37.086	7.632	−71.968	1.00	28.15	C
ATOM	915	NZ	LYS		132	−37.755	6.754	−72.962	1.00	29.18	N
ATOM	916	C	LYS		132	−35.587	11.789	−73.425	1.00	28.00	C
ATOM	917	O	LYS		132	−36.744	11.561	−73.778	1.00	28.35	O
ATOM	918	N	PRO		133	−35.246	12.961	−72.862	1.00	26.58	N
ATOM	919	CD	PRO		133	−33.969	13.407	−72.286	1.00	26.85	C
ATOM	920	CA	PRO		133	−36.281	13.992	−72.702	1.00	26.73	C
ATOM	921	CB	PRO		133	−35.506	15.168	−72.113	1.00	26.29	C
ATOM	922	CG	PRO		133	−34.418	14.500	−71.342	1.00	27.48	C
ATOM	923	C	PRO		133	−36.928	14.343	−74.048	1.00	26.15	C
ATOM	924	O	PRO		133	−38.152	14.468	−74.150	1.00	25.37	O
ATOM	925	N	PHE		134	−36.093	14.485	−75.075	1.00	26.38	N
ATOM	926	CA	PHE		134	−36.562	14.819	−76.420	1.00	25.94	C
ATOM	927	CB	PHE		134	−35.377	14.963	−77.374	1.00	25.81	C
ATOM	928	CG	PHE		134	−35.738	15.568	−78.708	1.00	23.50	C
ATOM	929	CD1	PHE		134	−35.619	16.935	−78.919	1.00	23.91	C
ATOM	930	CD2	PHE		134	−36.204	14.773	−79.744	1.00	24.67	C
ATOM	931	CE1	PHE		134	−35.960	17.502	−80.143	1.00	23.40	C
ATOM	932	CE2	PHE		134	−36.549	15.331	−80.967	1.00	23.00	C
ATOM	933	CZ	PHE		134	−36.425	16.700	−81.166	1.00	21.42	C
ATOM	934	C	PHE		134	−37.481	13.723	−76.939	1.00	25.70	C
ATOM	935	O	PHE		134	−38.558	13.998	−77.472	1.00	26.34	O
ATOM	936	N	GLU		135	−37.045	12.477	−76.778	1.00	24.98	N
ATOM	937	CA	GLU		135	−37.820	11.329	−77.226	1.00	23.08	C
ATOM	938	CB	GLU		135	−37.062	10.038	−76.922	1.00	24.77	C
ATOM	939	CG	GLU		135	−37.873	8.783	−77.164	1.00	27.59	C
ATOM	940	CD	GLU		135	−37.165	7.538	−76.665	1.00	29.43	C
ATOM	941	OE1	GLU		135	−35.993	7.334	−77.042	1.00	29.33	O
ATOM	942	OE2	GLU		135	−37.782	6.767	−75.898	1.00	30.32	O
ATOM	943	C	GLU		135	−39.204	11.242	−76.591	1.00	23.38	C
ATOM	944	O	GLU		135	−40.212	11.102	−77.291	1.00	22.48	O
ATOM	945	N	ASP		136	−39.255	11.299	−75.265	1.00	22.85	N
ATOM	946	CA	ASP		136	−40.529	11.210	−74.562	1.00	24.33	C
ATOM	947	CB	ASP		136	−40.310	11.246	−73.046	1.00	26.28	C
ATOM	948	CG	ASP		136	−39.700	9.953	−72.517	1.00	29.87	C
ATOM	949	OD1	ASP		136	−40.062	8.873	−73.035	1.00	29.17	O
ATOM	950	OD2	ASP		136	−38.874	10.015	−71.582	1.00	31.48	O
ATOM	951	C	ASP		136	−41.490	12.319	−74.982	1.00	21.95	C
ATOM	952	O	ASP		136	−42.684	12.081	−75.190	1.00	22.06	O
ATOM	953	N	ALA		137	−40.961	13.530	−75.104	1.00	21.91	N
ATOM	954	CA	ALA		137	−41.768	14.666	−75.522	1.00	21.26	C
ATOM	955	CB	ALA		137	−40.943	15.947	−75.455	1.00	20.37	C
ATOM	956	C	ALA		137	−42.251	14.413	−76.949	1.00	20.38	C
ATOM	957	O	ALA		137	−43.426	14.580	−77.252	1.00	20.12	O
ATOM	958	N	SER		138	−41.341	13.981	−77.824	1.00	22.62	N
ATOM	959	CA	SER		138	−41.697	13.720	−79.219	1.00	22.67	C
ATOM	960	CB	SER		138	−40.473	13.249	−80.012	1.00	20.70	C
ATOM	961	OG	SER		138	−39.488	14.264	−80.071	1.00	19.37	O
ATOM	962	C	SER		138	−42.815	12.696	−79.371	1.00	24.65	C
ATOM	963	O	SER		138	−43.728	12.889	−80.173	1.00	25.67	O
ATOM	964	N	PHE		139	−42.746	11.608	−78.610	1.00	25.28	N
ATOM	965	CA	PHE		139	−43.771	10.570	−78.694	1.00	26.75	C
ATOM	966	CB	PHE		139	−43.216	9.221	−78.208	1.00	28.02	C
ATOM	967	CG	PHE		139	−42.364	8.514	−79.236	1.00	28.77	C
ATOM	968	CD1	PHE		139	−41.032	8.865	−79.418	1.00	29.76	C
ATOM	969	CD2	PHE		139	−42.916	7.538	−80.056	1.00	30.32	C
ATOM	970	CE1	PHE		139	−40.260	8.253	−80.411	1.00	29.94	C
ATOM	971	CE2	PHE		139	−42.152	6.922	−81.050	1.00	29.34	C
ATOM	972	CZ	PHE		139	−40.824	7.281	−81.226	1.00	27.71	C
ATOM	973	C	PHE		139	−45.058	10.911	−77.944	1.00	25.38	C
ATOM	974	O	PHE		139	−46.099	10.301	−78.179	1.00	26.52	O
ATOM	975	N	ALA		140	−44.992	11.888	−77.049	1.00	25.00	N
ATOM	976	CA	ALA		140	−46.172	12.291	−76.296	1.00	25.17	C
ATOM	977	CB	ALA		140	−45.763	12.858	−74.946	1.00	24.70	C
ATOM	978	C	ALA		140	−46.986	13.321	−77.079	1.00	26.27	C
ATOM	979	O	ALA		140	−48.119	13.635	−76.712	1.00	27.77	O
ATOM	980	N	LEU		141	−46.409	13.853	−78.151	1.00	25.18	N
ATOM	981	CA	LEU		141	−47.111	14.834	−78.976	1.00	25.68	C
ATOM	982	CB	LEU		141	−46.117	15.761	−79.694	1.00	23.76	C
ATOM	983	CG	LEU		141	−45.236	16.762	−78.937	1.00	22.59	C
ATOM	984	CD1	LEU		141	−44.108	17.247	−79.866	1.00	21.95	C
ATOM	985	CD2	LEU		141	−46.082	17.939	−78.455	1.00	23.55	C
ATOM	986	C	LEU		141	−47.912	14.098	−80.037	1.00	26.34	C
ATOM	987	O	LEU		141	−47.556	12.988	−80.428	1.00	27.81	O
ATOM	988	N	ARG		142	−49.008	14.693	−80.492	1.00	26.50	N
ATOM	989	CA	ARG		142	−49.768	14.080	−81.572	1.00	26.45	C
ATOM	990	CB	ARG		142	−51.279	14.200	−81.354	1.00	29.70	C
ATOM	991	CG	ARG		142	−51.846	13.134	−80.418	1.00	34.09	C
ATOM	992	CD	ARG		142	−51.898	13.621	−78.985	1.00	37.77	C
ATOM	993	NE	ARG		142	−52.891	14.679	−78.840	1.00	42.23	N
ATOM	994	CZ	ARG		142	−53.231	15.233	−77.683	1.00	44.44	C
ATOM	995	NH1	ARG		142	−52.658	14.825	−76.557	1.00	48.32	N
ATOM	996	NH2	ARG		142	−54.146	16.191	−77.652	1.00	43.79	N
ATOM	997	C	ARG		142	−49.353	14.842	−82.822	1.00	25.79	C
ATOM	998	O	ARG		142	−48.806	15.943	−82.727	1.00	24.41	O
ATOM	999	N	THR		143	−49.581	14.261	−83.990	1.00	25.14	N
ATOM	1000	CA	THR		143	−49.201	14.929	−85.223	1.00	25.72	C
ATOM	1001	CB	THR		143	−49.670	14.131	−86.440	1.00	25.95	C
ATOM	1002	OG1	THR		143	−49.005	12.861	−86.441	1.00	31.01	O
ATOM	1003	CG2	THR		143	−49.345	14.871	−87.725	1.00	25.05	C
ATOM	1004	C	THR		143	−49.794	16.331	−85.270	1.00	25.02	C
ATOM	1005	O	THR		143	−50.991	16.522	−85.034	1.00	24.82	O
ATOM	1006	N	GLY		144	−48.944	17.313	−85.555	1.00	24.79	N
ATOM	1007	CA	GLY		144	−49.397	18.689	−85.626	1.00	23.53	C
ATOM	1008	C	GLY		144	−49.163	19.506	−84.368	1.00	23.60	C
ATOM	1009	O	GLY		144	−49.125	20.741	−84.428	1.00	23.43	O
ATOM	1010	N	GLU		145	−49.001	18.838	−83.227	1.00	21.53	N
ATOM	1011	CA	GLU		145	−48.788	19.545	−81.961	1.00	21.14	C
ATOM	1012	CB	GLU		145	−49.223	18.681	−80.776	1.00	22.83	C
ATOM	1013	CG	GLU		145	−50.663	18.208	−80.823	1.00	25.99	C
ATOM	1014	CD	GLU		145	−51.059	17.490	−79.550	1.00	26.70	C
ATOM	1015	OE1	GLU		145	−50.337	16.548	−79.151	1.00	28.91	O
ATOM	1016	OE2	GLU		145	−52.084	17.865	−78.948	1.00	27.26	O
ATOM	1017	C	GLU		145	−47.348	19.973	−81.729	1.00	21.30	C
ATOM	1018	O	GLU		145	−46.410	19.390	−82.282	1.00	21.08	O
ATOM	1019	N	MET		146	−47.190	20.989	−80.889	1.00	18.68	N
ATOM	1020	CA	MET		146	−45.882	21.526	−80.552	1.00	19.46	C
ATOM	1021	CB	MET		146	−45.783	22.981	−81.009	1.00	18.85	C
ATOM	1022	CG	MET		146	−44.435	23.639	−80.761	1.00	18.89	C
ATOM	1023	SD	MET		146	−44.413	25.338	−81.381	1.00	21.55	S
ATOM	1024	CE	MET		146	−45.240	26.201	−80.028	1.00	17.39	C
ATOM	1025	C	MET		146	−45.671	21.431	−79.042	1.00	18.99	C
ATOM	1026	O	MET		146	−46.626	21.446	−78.265	1.00	20.10	O
ATOM	1027	N	SER		147	−44.414	21.325	−78.634	1.00	17.69	N
ATOM	1028	CA	SER		147	−44.077	21.231	−77.220	1.00	17.26	C
ATOM	1029	CB	SER		147	−42.826	20.368	−77.028	1.00	15.40	C
ATOM	1030	OG	SER		147	−41.666	21.097	−77.441	1.00	15.70	O
ATOM	1031	C	SER		147	−43.771	22.605	−76.642	1.00	16.73	C
ATOM	1032	O	SER		147	−43.735	23.606	−77.357	1.00	17.85	O
ATOM	1033	N	GLY		148	−43.561	22.626	−75.330	1.00	17.38	N
ATOM	1034	CA	GLY		148	−43.161	23.837	−74.647	1.00	16.78	C
ATOM	1035	C	GLY		148	−41.661	23.636	−74.513	1.00	20.67	C
ATOM	1036	O	GLY		148	−41.094	22.813	−75.240	1.00	20.08	O
ATOM	1037	N	PRO		149	−40.973	24.353	−73.617	1.00	20.90	N
ATOM	1038	CD	PRO		149	−41.402	25.484	−72.777	1.00	22.14	C
ATOM	1039	CA	PRO		149	−39.525	24.135	−73.508	1.00	22.59	C
ATOM	1040	CB	PRO		149	−39.089	25.180	−72.480	1.00	22.61	C
ATOM	1041	CG	PRO		149	−40.119	26.280	−72.651	1.00	23.58	C
ATOM	1042	C	PRO		149	−39.193	22.716	−73.042	1.00	21.40	C
ATOM	1043	O	PRO		149	−39.727	22.253	−72.041	1.00	21.18	O
ATOM	1044	N	VAL		150	−38.320	22.029	−73.775	1.00	20.95	N
ATOM	1045	CA	VAL		150	−37.901	20.675	−73.410	1.00	20.87	C
ATOM	1046	CB	VAL		150	−38.278	19.649	−74.506	1.00	20.94	C
ATOM	1047	CG1	VAL		150	−37.715	18.277	−74.160	1.00	19.63	C
ATOM	1048	CG2	VAL		150	−39.792	19.559	−74.626	1.00	20.42	C
ATOM	1049	C	VAL		150	−36.379	20.694	−73.199	1.00	22.53	C
ATOM	1050	O	VAL		150	−35.615	20.998	−74.115	1.00	22.76	O
ATOM	1051	N	PHE		151	−35.950	20.371	−71.979	1.00	22.62	N
ATOM	1052	CA	PHE		151	−34.538	20.398	−71.622	1.00	24.13	C
ATOM	1053	CB	PHE		151	−34.390	20.800	−70.147	1.00	23.82	C
ATOM	1054	CG	PHE		151	−35.044	22.116	−69.803	1.00	25.62	C
ATOM	1055	CD1	PHE		151	−36.420	22.212	−69.674	1.00	24.72	C
ATOM	1056	CD2	PHE		151	−34.277	23.257	−69.621	1.00	25.61	C
ATOM	1057	CE1	PHE		151	−37.019	23.422	−69.373	1.00	25.22	C
ATOM	1058	CE2	PHE		151	−34.870	24.475	−69.319	1.00	24.74	C
ATOM	1059	CZ	PHE		151	−36.244	24.557	−69.194	1.00	24.70	C
ATOM	1060	C	PHE		151	−33.768	19.090	−71.852	1.00	24.55	C
ATOM	1061	O	PHE		151	−34.250	18.006	−71.524	1.00	25.76	O
ATOM	1062	N	THR		152	−32.572	19.207	−72.427	1.00	26.27	N
ATOM	1063	CA	THR		152	−31.693	18.057	−72.663	1.00	24.71	C
ATOM	1064	CB	THR		152	−31.794	17.499	−74.097	1.00	25.44	C
ATOM	1065	OG1	THR		152	−31.284	18.472	−75.015	1.00	25.05	O
ATOM	1066	CG2	THR		152	−33.236	17.138	−74.452	1.00	24.56	C
ATOM	1067	C	THR		152	−30.262	18.557	−72.476	1.00	24.73	C
ATOM	1068	O	THR		152	−30.037	19.759	−72.313	1.00	25.48	O
ATOM	1069	N	ASP		153	−29.299	17.641	−72.516	1.00	27.83	N
ATOM	1070	CA	ASP		153	−27.890	17.999	−72.358	1.00	28.92	C
ATOM	1071	CB	ASP		153	−27.038	16.736	−72.294	1.00	32.71	C
ATOM	1072	CG	ASP		153	−26.902	16.203	−70.885	1.00	35.95	C
ATOM	1073	OD1	ASP		153	−27.773	16.504	−70.040	1.00	37.21	O
ATOM	1074	OD2	ASP		153	−25.923	15.474	−70.620	1.00	38.87	O
ATOM	1075	C	ASP		153	−27.373	18.907	−73.467	1.00	29.41	C
ATOM	1076	O	ASP		153	−26.347	19.574	−73.304	1.00	30.52	O
ATOM	1077	N	SER		154	−28.080	18.929	−74.592	1.00	27.80	N
ATOM	1078	CA	SER		154	−27.687	19.766	−75.721	1.00	27.31	C
ATOM	1079	CB	SER		154	−28.281	19.222	−77.015	1.00	28.73	C
ATOM	1080	OG	SER		154	−27.774	17.932	−77.281	1.00	34.18	O
ATOM	1081	C	SER		154	−28.152	21.193	−75.527	1.00	26.36	C
ATOM	1082	O	SER		154	−27.510	22.132	−76.002	1.00	26.07	O
ATOM	1083	N	GLY		155	−29.273	21.347	−74.830	1.00	25.85	N
ATOM	1084	CA	GLY		155	−29.826	22.668	−74.584	1.00	23.67	C
ATOM	1085	C	GLY		155	−31.341	22.617	−74.443	1.00	23.57	C
ATOM	1086	O	GLY		155	−31.903	21.589	−74.050	1.00	22.45	O
ATOM	1087	N	ILE		156	−32.011	23.717	−74.762	1.00	22.57	N
ATOM	1088	CA	ILE		156	−33.469	23.755	−74.656	1.00	21.80	C
ATOM	1089	CB	ILE		156	−33.927	25.036	−73.930	1.00	22.22	C
ATOM	1090	CG2	ILE		156	−35.427	24.963	−73.639	1.00	22.67	C
ATOM	1091	CG1	ILE		156	−33.154	25.187	−72.614	1.00	23.67	C
ATOM	1092	CD1	ILE		156	−33.429	26.477	−71.856	1.00	22.08	C
ATOM	1093	C	ILE		156	−34.111	23.690	−76.051	1.00	21.35	C
ATOM	1094	O	ILE		156	−33.731	24.435	−76.955	1.00	21.51	O
ATOM	1095	N	HIS		157	−35.085	22.801	−76.219	1.00	20.45	N
ATOM	1096	CA	HIS		157	−35.750	22.639	−77.510	1.00	20.71	C
ATOM	1097	CB	HIS		157	−35.720	21.181	−77.973	1.00	21.57	C
ATOM	1098	CG	HIS		157	−34.393	20.505	−77.850	1.00	26.02	C
ATOM	1099	CD2	HIS		157	−33.715	20.057	−76.766	1.00	25.70	C
ATOM	1100	ND1	HIS		157	−33.657	20.117	−78.949	1.00	24.87	N
ATOM	1101	CE1	HIS		157	−32.587	19.456	−78.549	1.00	28.61	C
ATOM	1102	NE2	HIS		157	−32.597	19.403	−77.227	1.00	27.09	N
ATOM	1103	C	HIS		157	−37.232	23.003	−77.519	1.00	20.51	C
ATOM	1104	O	HIS		157	−37.899	23.004	−76.483	1.00	18.94	O
ATOM	1105	N	ILE		158	−37.723	23.300	−78.719	1.00	19.88	N
ATOM	1106	CA	ILE		158	−39.143	23.526	−78.969	1.00	19.79	C
ATOM	1107	CB	ILE		158	−39.473	24.853	−79.680	1.00	20.20	C
ATOM	1108	CG2	ILE		158	−40.975	24.900	−79.981	1.00	22.54	C
ATOM	1109	CG1	ILE		158	−39.125	26.048	−78.796	1.00	20.64	C
ATOM	1110	CD1	ILE		158	−39.243	27.370	−79.523	1.00	21.18	C
ATOM	1111	C	ILE		158	−39.294	22.407	−79.993	1.00	19.18	C
ATOM	1112	O	ILE		158	−38.526	22.343	−80.958	1.00	20.90	O
ATOM	1113	N	ILE		159	−40.248	21.513	−79.781	1.00	19.24	N
ATOM	1114	CA	ILE		159	−40.432	20.394	−80.693	1.00	19.82	C
ATOM	1115	CB	ILE		159	−40.296	19.057	−79.933	1.00	20.20	C
ATOM	1116	CG2	ILE		159	−40.390	17.892	−80.900	1.00	19.48	C
ATOM	1117	CG1	ILE		159	−38.978	19.040	−79.151	1.00	21.22	C
ATOM	1118	CD1	ILE		159	−38.818	17.835	−78.225	1.00	20.27	C
ATOM	1119	C	ILE		159	−41.788	20.418	−81.383	1.00	20.04	C
ATOM	1120	O	ILE		159	−42.813	20.655	−80.748	1.00	20.28	O
ATOM	1121	N	LEU		160	−41.784	20.173	−82.691	1.00	19.71	N
ATOM	1122	CA	LEU		160	−43.016	20.139	−83.470	1.00	21.46	C
ATOM	1123	CB	LEU		160	−43.002	21.236	−84.543	1.00	18.33	C
ATOM	1124	CG	LEU		160	−44.134	21.169	−85.578	1.00	20.27	C
ATOM	1125	CD1	LEU		160	−45.439	21.610	−84.933	1.00	18.83	C
ATOM	1126	CD2	LEU		160	−43.807	22.054	−86.777	1.00	20.48	C
ATOM	1127	C	LEU		160	−43.126	18.776	−84.144	1.00	19.87	C
ATOM	1128	O	LEU		160	−42.265	18.412	−84.940	1.00	22.21	O
ATOM	1129	N	ARG		161	−44.164	18.013	−83.814	1.00	20.44	N
ATOM	1130	CA	ARG		161	−44.331	16.707	−84.444	1.00	21.77	C
ATOM	1131	CB	ARG		161	−45.111	15.730	−83.545	1.00	20.86	C
ATOM	1132	CG	ARG		161	−45.326	14.386	−84.234	1.00	22.18	C
ATOM	1133	CD	ARG		161	−46.023	13.337	−83.369	1.00	24.94	C
ATOM	1134	NE	ARG		161	−46.353	12.173	−84.194	1.00	26.23	N
ATOM	1135	CZ	ARG		161	−47.072	11.129	−83.792	1.00	26.97	C
ATOM	1136	NH1	ARG		161	−47.556	11.072	−82.555	1.00	26.11	N
ATOM	1137	NH2	ARG		161	−47.334	10.150	−84.649	1.00	25.86	N
ATOM	1138	C	ARG		161	−45.058	16.885	−85.771	1.00	21.34	C
ATOM	1139	O	ARG		161	−46.184	17.399	−85.819	1.00	21.53	O
ATOM	1140	N	THR		162	−44.414	16.443	−86.848	1.00	20.99	N
ATOM	1141	CA	THR		162	−44.973	16.587	−88.183	1.00	21.74	C
ATOM	1142	CB	THR		162	−43.902	17.093	−89.164	1.00	21.75	C
ATOM	1143	OG1	THR		162	−42.786	16.193	−89.159	1.00	22.79	O
ATOM	1144	CG2	THR		162	−43.423	18.476	−88.756	1.00	20.14	C
ATOM	1145	C	THR		162	−45.598	15.321	−88.763	1.00	22.35	C
ATOM	1146	O	THR		162	−46.410	15.401	−89.681	1.00	21.77	O
ATOM	1147	N	GLU		163	−45.219	14.160	−88.240	1.00	23.01	N
ATOM	1148	CA	GLU		163	−45.764	12.892	−88.722	1.00	24.66	C
ATOM	1149	CB	GLU		163	−44.922	12.351	−89.886	1.00	26.75	C
ATOM	1150	CG	GLU		163	−45.067	13.113	−91.199	1.00	29.47	C
ATOM	1151	CD	GLU		163	−44.221	12.520	−92.322	1.00	31.32	C
ATOM	1152	OE1	GLU		163	−43.978	11.295	−92.310	1.00	34.13	O
ATOM	1153	OE2	GLU		163	−43.810	13.275	−93.229	1.00	33.14	O
ATOM	1154	C	GLU		163	−45.791	11.861	−87.599	1.00	24.13	C
ATOM	1155	O	GLU		163	−45.014	12.024	−86.636	1.00	23.91	O
ATOM	1156	OXT	GLU		163	−46.576	10.894	−87.702	1.00	22.62	O
TER	1157		GLU		163
ATOM	1158	OH2	TIP	S	1	−30.337	14.954	−72.530	1.00	33.70	O
ATOM	1159	OH2	TIP	S	2	−28.518	12.454	−73.081	1.00	59.22	O
ATOM	1160	OH2	TIP	S	3	−42.407	18.833	−67.228	1.00	25.30	O
ATOM	1161	OH2	TIP	S	4	−30.117	28.059	−91.462	1.00	25.64	O
ATOM	1162	OH2	TIP	S	5	−40.380	17.343	−89.509	1.00	19.75	O
ATOM	1163	OH2	TIP	S	6	−51.559	29.839	−80.956	1.00	23.09	O
ATOM	1164	OH2	TIP	S	7	−33.084	23.028	−85.769	1.00	18.45	O
ATOM	1165	OH2	TIP	S	8	−49.705	15.932	−76.489	1.00	20.89	O
ATOM	1166	OH2	TIP	S	9	−48.270	17.998	−75.530	1.00	23.27	O
ATOM	1167	OH2	TIP	S	10	−33.529	23.201	−96.630	1.00	23.43	O
ATOM	1168	OH2	TIP	S	11	−39.504	21.647	−90.269	1.00	27.54	O
ATOM	1169	OH2	TIP	S	12	−47.319	29.740	−86.121	1.00	19.52	O
ATOM	1170	OH2	TIP	S	13	−31.282	32.273	−80.133	1.00	34.78	O
ATOM	1171	OH2	TIP	S	14	−43.845	31.200	−74.053	1.00	26.14	O
ATOM	1172	OH2	TIP	S	15	−35.552	8.241	−79.720	1.00	29.46	O
ATOM	1173	OH2	TIP	S	16	−37.006	35.310	−78.208	1.00	29.54	O
ATOM	1174	OH2	TIP	S	17	−33.961	25.655	−93.710	1.00	26.17	O
ATOM	1175	OH2	TIP	S	18	−51.888	27.636	−76.726	1.00	22.19	O
ATOM	1176	OH2	TIP	S	19	−26.271	30.912	−80.966	1.00	28.70	O
ATOM	1177	OH2	TIP	S	20	−38.827	16.619	−69.736	1.00	39.37	O
ATOM	1178	OH2	TIP	S	21	−49.434	28.867	−71.190	1.00	20.55	O
ATOM	1179	OH2	TIP	S	22	−32.140	36.255	−88.668	1.00	37.74	O
ATOM	1180	OH2	TIP	S	23	−60.015	26.342	−70.598	1.00	21.35	O
ATOM	1181	OH2	TIP	S	24	−45.809	25.641	−70.682	1.00	28.99	O
ATOM	1182	OH2	TIP	S	25	−42.897	28.468	−72.565	1.00	43.74	O
ATOM	1183	OH2	TIP	S	26	−43.489	9.674	−74.213	1.00	27.81	O
ATOM	1184	OH2	TIP	S	27	−50.822	30.594	−64.230	1.00	40.56	O
ATOM	1185	OH2	TIP	S	28	−29.865	30.158	−80.820	1.00	31.54	O
ATOM	1186	OH2	TIP	S	29	−33.525	35.890	−81.494	1.00	34.70	O
ATOM	1187	OH2	TIP	S	30	−51.371	20.598	−78.078	1.00	24.51	O
ATOM	1188	OH2	TIP	S	31	−45.449	8.539	−87.591	1.00	43.02	O
ATOM	1189	OH2	TIP	S	32	−14.149	25.806	−82.260	1.00	43.99	O
ATOM	1190	OH2	TIP	S	33	−41.517	14.015	−67.503	1.00	55.85	O
ATOM	1191	OH2	TIP	S	34	−11.982	27.431	−85.358	1.00	48.42	O
ATOM	1192	OH2	TIP	S	35	−40.187	3.296	−81.256	1.00	45.12	O
ATOM	1193	OH2	TIP	S	36	−42.979	8.781	−89.768	1.00	45.38	O
ATOM	1194	OH2	TIP	S	37	−27.607	33.252	−86.887	1.00	45.41	O
ATOM	1195	OH2	TIP	S	38	−17.963	32.867	−80.490	1.00	47.42	O
ATOM	1196	OH2	TIP	S	39	−28.697	35.008	−66.626	1.00	48.87	O
ATOM	1197	OH2	TIP	S	40	−38.935	35.933	−73.191	1.00	49.10	O
ATOM	1198	OH2	TIP	S	41	−50.114	12.504	−75.199	1.00	33.28	O
ATOM	1199	OH2	TIP	S	42	−54.173	17.457	−82.064	1.00	43.74	O
ATOM	1200	OH2	TIP	S	43	−32.369	36.085	−73.534	1.00	41.64	O
ATOM	1201	OH2	TIP	S	44	−54.571	27.801	−75.888	1.00	21.30	O
ATOM	1202	OH2	TIP	S	45	−41.306	18.099	−92.015	1.00	24.32	O
ATOM	1203	OH2	TIP	S	46	−36.529	37.091	−83.137	1.00	68.47	O
ATOM	1204	OH2	TIP	S	47	−49.709	22.115	−80.069	1.00	21.44	O
ATOM	1205	OH2	TIP	S	48	−28.084	35.045	−77.109	1.00	42.57	O
ATOM	1206	OH2	TIP	S	49	−42.317	33.269	−90.557	1.00	46.57	O
ATOM	1207	OH2	TIP	S	50	−63.208	29.033	−71.148	1.00	30.45	O
ATOM	1208	OH2	TIP	S	51	−62.437	27.647	−66.494	1.00	64.69	O
ATOM	1209	OH2	TIP	S	52	−39.659	30.883	−67.696	1.00	53.29	O
ATOM	1210	OH2	TIP	S	53	−35.857	17.335	−94.700	1.00	43.07	O
ATOM	1211	OH2	TIP	S	54	−39.954	25.935	−68.347	1.00	46.56	O
ATOM	1212	OH2	TIP	S	55	−43.716	19.857	−92.127	1.00	42.42	O
ATOM	1213	OH2	TIP	S	56	−51.353	11.615	−84.018	1.00	40.85	O
ATOM	1214	OH2	TIP	S	57	−30.888	11.817	−70.131	1.00	58.48	O
ATOM	1215	OH2	TIP	S	58	−29.602	34.602	−80.235	1.00	51.31	O
ATOM	1216	OH2	TIP	S	59	−48.994	10.803	−79.387	1.00	43.69	O
ATOM	1217	OH2	TIP	S	60	−27.762	11.513	−69.875	1.00	49.05	O
ATOM	1218	OH2	TIP	S	61	−39.270	12.603	−69.751	1.00	58.22	O
ATOM	1219	OH2	TIP	S	62	−40.665	28.632	−69.086	1.00	37.07	O
ATOM	1220	OH2	TIP	S	63	−54.886	30.276	−77.021	1.00	41.33	O
ATOM	1221	OH2	TIP	S	64	−34.693	37.646	−74.632	1.00	49.20	O
ATOM	1222	OH2	TIP	S	65	−48.301	39.542	−79.955	1.00	45.44	O
ATOM	1223	OH2	TIP	S	66	−12.093	31.226	−84.857	1.00	36.29	O
ATOM	1224	OH2	TIP	S	67	−51.607	32.331	−70.705	1.00	27.61	O
ATOM	1225	OH2	TIP	S	68	−45.668	27.590	−86.746	1.00	32.59	O
ATOM	1226	OH2	TIP	S	69	−48.636	23.216	−83.337	1.00	22.73	O
ATOM	1227	OH2	TIP	S	70	−48.648	19.834	−77.586	1.00	23.07	O
ATOM	1228	OH2	TIP	S	71	−33.514	7.561	−75.757	1.00	35.63	O
ATOM	1229	OH2	TIP	S	72	−40.632	6.519	−71.318	1.00	41.26	O
ATOM	1230	OH2	TIP	S	73	−62.269	22.614	−70.554	1.00	44.71	O
ATOM	1231	OH2	TIP	S	74	−46.905	25.356	−83.742	1.00	24.16	O
ATOM	1232	OH2	TIP	S	75	−64.076	27.283	−69.350	1.00	38.89	O
ATOM	1233	OH2	TIP	S	76	−50.744	37.111	−68.228	1.00	77.57	O
ATOM	1234	OH2	TIP	S	77	−46.528	9.140	−74.024	1.00	44.32	O
ATOM	1235	OH2	TIP	S	78	−53.608	14.722	−84.884	1.00	65.45	O
ATOM	1236	OH2	TIP	S	79	−35.783	17.086	−69.371	1.00	29.05	O
ATOM	1237	OH2	TIP	S	80	−46.630	28.205	−64.350	1.00	102.24	O
ATOM	1238	OH2	TIP	S	81	−30.431	10.412	−73.191	1.00	46.43	O
ATOM	1239	OH2	TIP	S	82	−46.601	33.719	−72.320	1.00	45.24	O
ATOM	1240	OH2	TIP	S	83	−24.405	33.010	−76.648	1.00	39.62	O
ATOM	1241	OH2	TIP	S	84	−30.625	22.533	−71.178	1.00	32.04	O
ATOM	1242	OH2	TIP	S	85	−60.609	28.704	−71.946	1.00	30.44	O
ATOM	1243	OH2	TIP	S	86	−32.078	6.382	−73.765	1.00	34.41	O
ATOM	1244	OH2	TIP	S	87	−34.251	10.667	−88.680	1.00	41.45	O
ATOM	1245	OH2	TIP	S	88	−36.267	26.858	−98.249	1.00	34.75	O
ATOM	1246	OH2	TIP	S	89	−45.789	30.297	−70.068	1.00	71.72	O
ATOM	1247	OH2	TIP	S	90	−49.953	9.533	−82.267	1.00	52.83	O
ATOM	1248	OH2	TIP	S	91	−51.226	25.924	−79.649	1.00	58.17	O
ATOM	1249	OH2	TIP	S	92	−19.141	34.369	−78.416	1.00	61.29	O
ATOM	1250	OH2	TIP	S	93	−35.480	32.681	−68.080	1.00	47.59	O
ATOM	1251	OH2	TIP	S	94	−25.051	34.480	−83.347	1.00	80.24	O
ATOM	1252	OH2	TIP	S	95	−42.054	21.988	−91.705	1.00	68.86	O
ATOM	1253	OH2	TIP	S	96	−46.250	9.131	−92.563	1.00	56.89	O
ATOM	1254	OH2	TIP	S	97	−47.135	25.273	−65.710	1.00	63.26	O
ATOM	1255	OH2	TIP	S	98	−30.311	34.474	−88.303	1.00	57.79	O
ATOM	1256	OH2	TIP	S	99	−35.355	25.072	−65.170	1.00	59.44	O
ATOM	1257	OH2	TIP	S	100	−36.754	37.084	−87.208	1.00	43.03	O
ATOM	1258	OH2	TIP	S	101	−45.923	38.561	−89.332	1.00	66.40	O
ATOM	1259	OH2	TIP	S	102	−15.689	32.401	−84.562	1.00	39.71	O
ATOM	1260	OH2	TIP	S	103	−43.773	16.583	−93.009	1.00	51.40	O
ATOM	1261	OH2	TIP	S	104	−43.338	39.639	−84.060	1.00	56.17	O
ATOM	1262	OH2	TIP	S	105	−24.135	19.481	−76.887	1.00	39.93	O
ATOM	1263	OH2	TIP	S	106	−47.385	31.671	−88.352	1.00	40.93	O
ATOM	1264	OH2	TIP	S	107	−48.459	14.492	−91.751	1.00	68.59	O
ATOM	1265	OH2	TIP	S	108	−31.614	25.550	−62.406	1.00	54.75	O
ATOM	1266	OH2	TIP	S	109	−35.343	31.207	−65.533	1.00	56.29	O
ATOM	1267	OH2	TIP	S	110	−55.480	23.643	−79.605	1.00	45.22	O
ATOM	1268	OH2	TIP	S	111	−44.623	5.552	−72.549	1.00	61.00	O
ATOM	1269	OH2	TIP	S	112	−48.101	9.551	−68.190	1.00	54.21	O
ATOM	1270	OH2	TIP	S	113	−56.246	33.460	−94.882	1.00	81.49	O
ATOM	1271	OH2	TIP	S	114	−43.104	37.261	−90.400	1.00	63.81	O
ATOM	1272	OH2	TIP	S	115	−37.112	36.813	−76.082	1.00	48.92	O
ATOM	1273	OH2	TIP	S	116	−42.414	31.371	−93.110	1.00	49.45	O
ATOM	1274	OH2	TIP	S	117	−50.606	10.915	−87.418	1.00	51.38	O
TER	1275		TIP	S	117
ATOM	1276	O1	PGB	C	180	−48.146	28.969	−68.081	1.00	38.62	O
ATOM	1277	C2	PGB	C	180	−49.219	28.811	−67.252	1.00	38.72	C
ATOM	1278	C3	PGB	C	180	−50.409	29.694	−67.685	1.00	35.22	C
ATOM	1279	O4	PGB	C	180	−51.001	29.188	−68.770	1.00	33.83	O
ATOM	1280	C5	PGB	C	180	−52.287	29.537	−68.878	1.00	28.44	C
ATOM	1281	C6	PGB	C	180	−52.870	28.902	−70.156	1.00	26.59	C
ATOM	1282	O7	PGB	C	180	−52.380	29.548	−71.242	1.00	26.26	O
ATOM	1283	C8	PGB	C	180	−52.834	29.033	−72.401	1.00	22.02	C
ATOM	1284	C9	PGB	C	180	−52.235	29.817	−73.588	1.00	22.80	C
ATOM	1285	O10	PGB	C	180	−50.918	30.089	−73.362	1.00	21.70	O
ATOM	1286	C11	PGB	C	180	−50.361	30.778	−74.376	1.00	21.92	C
ATOM	1287	C12	PGB	C	180	−48.830	30.876	−74.161	1.00	23.81	C
ATOM	1288	O13	PGB	C	180	−48.261	29.652	−74.181	1.00	22.16	O
ATOM	1289	C14	PGB	C	180	−46.990	29.737	−73.745	1.00	24.89	C
ATOM	1290	C15	PGB	C	180	−46.390	28.323	−73.475	1.00	22.50	C
ATOM	1291	O16	PGB	C	180	−46.615	27.475	−74.497	1.00	24.49	O
ATOM	1292	C17	PGB	C	180	−46.095	26.316	−74.209	1.00	25.81	C
ATOM	1293	C18	PGB	C	180	−46.306	25.292	−75.326	1.00	26.85	C
ATOM	1294	O19	PGB	C	180	−47.601	25.057	−75.416	1.00	27.15	O
ATOM	1295	C20	PGB	C	180	−47.841	24.476	−76.556	1.00	28.30	C
ATOM	1296	C21	PGB	C	180	−49.043	23.932	−77.320	1.00	31.36	C
ATOM	1297	O22	PGB	C	180	−49.871	24.934	−77.537	1.00	32.87	O
TER	1298		PGB	C	180
ATOM	1299	C2	NMP	H	1	−30.808	14.296	−80.316	1.00	70.27	C
ATOM	1300	O6	NMP	H	1	−30.948	13.376	−79.515	1.00	69.64	O
ATOM	1301	C3	NMP	H	1	−29.808	14.273	−81.430	1.00	70.13	C
ATOM	1302	C4	NMP	H	1	−30.400	15.360	−82.370	1.00	69.97	C
ATOM	1303	C5	NMP	H	1	−31.077	16.362	−81.413	1.00	69.70	C
ATOM	1304	N1	NMP	H	1	−31.481	15.465	−80.348	1.00	69.83	N
ATOM	1305	C7	NMP	H	1	−32.511	15.754	−79.376	1.00	69.79	C
TER	1306		NMP	H	1
ATOM	1307	N2	221	I	1	−26.221	19.961	−84.419	1.00	80.03	N
ATOM	1308	C3	221	I	1	−24.903	20.102	−85.039	1.00	82.20	C
ATOM	1309	O8	221	I	1	−24.741	21.070	−85.948	1.00	81.64	O
ATOM	1310	C4	221	I	1	−23.904	19.251	−84.658	1.00	83.96	C
ATOM	1311	C17	221	I	1	−22.506	19.234	−85.155	1.00	89.77	C
ATOM	1312	C18	221	I	1	−21.648	20.413	−85.186	1.00	95.63	C
ATOM	1313	C22	221	I	1	−21.106	20.890	−86.305	1.00	97.93	C
ATOM	1314	C21	221	I	1	−20.354	22.053	−85.843	1.00	101.00	C
ATOM	1315	C20	221	I	1	−20.586	22.056	−84.530	1.00	101.71	C
ATOM	1316	I	221	I	1	−19.761	23.513	−83.285	1.00	111.65	I
ATOM	1317	O19	221	I	1	−21.374	21.084	−84.055	1.00	99.20	O
ATOM	1318	C5	221	I	1	−24.281	18.247	−83.627	1.00	81.88	C
ATOM	1319	O9	221	I	1	−23.400	17.453	−83.265	1.00	81.59	O
ATOM	1320	N6	221	I	1	−25.534	18.204	−83.133	1.00	79.46	N
ATOM	1321	C10	221	I	1	−25.837	17.259	−82.192	1.00	77.42	C
ATOM	1322	C11	221	I	1	−25.909	15.878	−82.578	1.00	76.11	C
ATOM	1323	C12	221	I	1	−26.225	14.902	−81.613	1.00	75.54	C
ATOM	1324	C13	221	I	1	−26.482	15.306	−80.266	1.00	75.42	C
ATOM	1325	CL16	221	I	1	−26.879	14.099	−79.069	1.00	73.86	CL
ATOM	1326	C14	221	I	1	−26.413	16.674	−79.875	1.00	75.47	C
ATOM	1327	C15	221	I	1	−26.094	17.655	−80.834	1.00	76.29	C
ATOM	1328	C1	221	I	1	−26.472	19.069	−83.530	1.00	79.63	C
ATOM	1329	S7	221	I	1	−28.129	18.952	−82.810	1.00	77.87	S

[0198] Pin1 R14A/Pin-051 Interactions

[0199] The crystal structure of the Pin1/Pin-051 co-complex (the coordinate set is set forth in Table 5), was examined for the interactions made between the polypeptide, the Pin-051 inhibitor molecule, and the solvent. The phenyl ring of Pin-051 is positioned in the hydrophobic pocket, and has favorable van der Waals distances with side chains Met130, Phe134, Leu122, His59, and His157. The five-atom ring is positioned through the cysteine/serine valley. The two rings have a torsional angle of 75.2 degrees. One of the oxygen atoms (012) of the pyrazole ring is positioned to interact with Pin1 through a bridging water molecule (S5) to Arg69. Water molecules (S1-S10) located within the active site also define the interaction template.

TABLE 5
Set of atomic coordinates of Pin1 R14A with PIN-051 bound in the active site.
ATOM	1	CB	LEU		7	21.710	45.910	−29.510	1.00	51.04	C
ATOM	2	CG	LEU		7	22.655	44.896	−28.855	1.00	50.86	C
ATOM	3	CD1	LEU		7	21.892	44.048	−27.852	1.00	50.76	C
ATOM	4	CD2	LEU		7	23.284	44.019	−29.924	1.00	50.57	C
ATOM	5	C	LEU		7	21.202	47.800	−31.062	1.00	49.65	C
ATOM	6	O	LEU		7	20.678	48.747	−30.474	1.00	49.15	O
ATOM	7	N	LEU		7	23.211	47.879	−29.600	1.00	50.70	N
ATOM	8	CA	LEU		7	22.321	46.995	−30.405	1.00	49.99	C
ATOM	9	N	PRO		8	20.821	47.431	−32.295	1.00	48.93	N
ATOM	10	CD	PRO		8	21.404	46.364	−33.126	1.00	49.65	C
ATOM	11	CA	PRO		8	19.753	48.128	−33.018	1.00	48.61	C
ATOM	12	CB	PRO		8	19.567	47.268	−34.264	1.00	49.25	C
ATOM	13	CG	PRO		8	20.949	46.754	−34.515	1.00	49.65	C
ATOM	14	C	PRO		8	18.476	48.222	−32.174	1.00	47.77	C
ATOM	15	O	PRO		8	18.343	47.545	−31.151	1.00	48.38	O
ATOM	16	N	PRO		9	17.516	49.059	−32.602	1.00	45.88	N
ATOM	17	CD	PRO		9	17.581	49.907	−33.806	1.00	44.79	C
ATOM	18	CA	PRO		9	16.244	49.261	−31.898	1.00	43.38	C
ATOM	19	CB	PRO		9	15.438	50.097	−32.889	1.00	43.53	C
ATOM	20	CG	PRO		9	16.493	50.925	−33.539	1.00	44.60	C
ATOM	21	C	PRO		9	15.484	48.012	−31.452	1.00	41.11	C
ATOM	22	O	PRO		9	14.982	47.243	−32.280	1.00	39.96	O
ATOM	23	N	GLY		10	15.402	47.825	−30.136	1.00	38.89	N
ATOM	24	CA	GLY		10	14.669	46.701	−29.581	1.00	34.84	C
ATOM	25	C	GLY		10	15.407	45.399	−29.323	1.00	31.78	C
ATOM	26	O	GLY		10	14.783	44.413	−28.938	1.00	27.63	O
ATOM	27	N	TRP		11	16.722	45.380	−29.519	1.00	31.53	N
ATOM	28	CA	TRP		11	17.494	44.157	−29.302	1.00	30.85	C
ATOM	29	CB	TRP		11	18.644	44.063	−30.306	1.00	29.22	C
ATOM	30	CG	TRP		11	18.200	43.807	−31.703	1.00	27.38	C
ATOM	31	CD2	TRP		11	17.840	42.542	−32.267	1.00	26.92	C
ATOM	32	CE2	TRP		11	17.458	42.775	−33.607	1.00	26.20	C
ATOM	33	CE3	TRP		11	17.802	41.231	−31.770	1.00	23.61	C
ATOM	34	CD1	TRP		11	18.028	44.730	−32.694	1.00	26.89	C
ATOM	35	NE1	TRP		11	17.582	44.120	−33.839	1.00	26.95	N
ATOM	36	CZ2	TRP		11	17.042	41.748	−34.458	1.00	25.56	C
ATOM	37	CZ3	TRP		11	17.388	40.210	−32.616	1.00	23.04	C
ATOM	38	CH2	TRP		11	17.013	40.475	−33.947	1.00	25.62	C
ATOM	39	C	TRP		11	18.057	44.015	−27.897	1.00	31.36	C
ATOM	40	O	TRP		11	18.389	45.003	−27.241	1.00	31.53	O
ATOM	41	N	GLU		12	18.155	42.770	−27.437	1.00	30.10	N
ATOM	42	CA	GLU		12	18.702	42.473	−26.119	1.00	29.25	C
ATOM	43	CB	GLU		12	17.583	42.356	−25.071	1.00	30.87	C
ATOM	44	CG	GLU		12	16.781	41.058	−25.106	1.00	33.77	C
ATOM	45	CD	GLU		12	15.676	41.025	−24.057	1.00	36.32	C
ATOM	46	OE1	GLU		12	14.691	41.785	−24.193	1.00	36.80	O
ATOM	47	OE2	GLU		12	15.792	40.241	−23.091	1.00	37.75	O
ATOM	48	C	GLU		12	19.479	41.162	−26.202	1.00	28.29	C
ATOM	49	O	GLU		12	19.225	40.336	−27.080	1.00	25.04	O
ATOM	50	N	LYS		13	20.434	40.984	−25.296	1.00	28.86	N
ATOM	51	CA	LYS		13	21.243	39.771	−25.268	1.00	29.81	C
ATOM	52	CB	LYS		13	22.611	40.060	−24.639	1.00	32.70	C
ATOM	53	CG	LYS		13	23.545	38.854	−24.594	1.00	36.69	C
ATOM	54	CD	LYS		13	24.775	39.124	−23.733	1.00	40.30	C
ATOM	55	CE	LYS		13	25.645	40.227	−24.320	1.00	41.72	C
ATOM	56	NZ	LYS		13	26.800	40.548	−23.429	1.00	44.20	N
ATOM	57	C	LYS		13	20.519	38.712	−24.454	1.00	28.54	C
ATOM	58	O	LYS		13	19.792	39.030	−23.513	1.00	28.62	O
ATOM	59	N	ALA		14	20.714	37.451	−24.821	1.00	26.70	N
ATOM	60	CA	ALA		14	20.082	36.344	−24.114	1.00	26.09	C
ATOM	61	CB	ALA		14	18.723	36.051	−24.723	1.00	26.43	C
ATOM	62	C	ALA		14	20.975	35.111	−24.207	1.00	26.33	C
ATOM	63	O	ALA		14	22.008	35.143	−24.871	1.00	25.06	O
ATOM	64	N	MET		15	20.575	34.034	−23.536	1.00	28.75	N
ATOM	65	CA	MET		15	21.326	32.780	−23.559	1.00	30.00	C
ATOM	66	CB	MET		15	22.044	32.529	−22.230	1.00	35.03	C
ATOM	67	CG	MET		15	23.160	33.489	−21.886	1.00	40.51	C
ATOM	68	SD	MET		15	24.120	32.838	−20.486	1.00	46.91	S
ATOM	69	CE	MET		15	22.932	32.996	−19.157	1.00	44.15	C
ATOM	70	C	MET		15	20.375	31.623	−23.794	1.00	29.47	C
ATOM	71	O	MET		15	19.312	31.555	−23.179	1.00	28.00	O
ATOM	72	N	SER		16	20.760	30.707	−24.675	1.00	28.02	N
ATOM	73	CA	SER		16	19.933	29.545	−24.955	1.00	28.13	C
ATOM	74	CB	SER		16	20.566	28.693	−26.053	1.00	28.39	C
ATOM	75	OG	SER		16	19.857	27.475	−26.210	1.00	29.48	O
ATOM	76	C	SER		16	19.787	28.706	−23.689	1.00	29.27	C
ATOM	77	O	SER		16	20.773	28.429	−23.004	1.00	28.57	O
ATOM	78	N	ARG		17	18.557	28.314	−23.375	1.00	31.08	N
ATOM	79	CA	ARG		17	18.301	27.491	−22.199	1.00	33.36	C
ATOM	80	CB	ARG		17	16.800	27.407	−21.916	1.00	34.58	C
ATOM	81	CG	ARG		17	16.208	28.683	−21.347	1.00	36.05	C
ATOM	82	CD	ARG		17	16.819	29.014	−19.997	1.00	35.82	C
ATOM	83	NE	ARG		17	16.458	30.358	−19.559	1.00	37.11	N
ATOM	84	CZ	ARG		17	15.246	30.719	−19.149	1.00	37.23	C
ATOM	85	NH1	ARG		17	14.257	29.836	−19.106	1.00	37.37	N
ATOM	86	NH2	ARG		17	15.022	31.976	−18.799	1.00	38.19	N
ATOM	87	C	ARG		17	18.848	26.092	−22.438	1.00	34.32	C
ATOM	88	O	ARG		17	19.125	25.351	−21.498	1.00	33.68	O
ATOM	89	N	SER		18	19.002	25.743	−23.709	1.00	34.58	N
ATOM	90	CA	SER		18	19.507	24.432	−24.093	1.00	35.96	C
ATOM	91	CB	SER		18	18.982	24.056	−25.482	1.00	36.36	C
ATOM	92	OG	SER		18	17.576	23.912	−25.476	1.00	39.84	O
ATOM	93	C	SER		18	21.027	24.360	−24.104	1.00	35.79	C
ATOM	94	O	SER		18	21.630	23.628	−23.321	1.00	36.71	O
ATOM	95	N	SER		19	21.640	25.131	−24.995	1.00	34.98	N
ATOM	96	CA	SER		19	23.089	25.135	−25.149	1.00	34.34	C
ATOM	97	CB	SER		19	23.445	25.408	−26.609	1.00	35.66	C
ATOM	98	OG	SER		19	22.974	26.682	−27.008	1.00	36.30	O
ATOM	99	C	SER		19	23.844	26.118	−24.270	1.00	33.33	C
ATOM	100	O	SER		19	25.014	25.901	−23.965	1.00	33.34	O
ATOM	101	N	GLY		20	23.187	27.201	−23.869	1.00	32.22	N
ATOM	102	CA	GLY		20	23.852	28.190	−23.039	1.00	30.95	C
ATOM	103	C	GLY		20	24.556	29.237	−23.888	1.00	29.69	C
ATOM	104	O	GLY		20	25.124	30.203	−23.375	1.00	28.89	O
ATOM	105	N	ARG		21	24.518	29.042	−25.200	1.00	28.35	N
ATOM	106	CA	ARG		21	25.151	29.973	−26.117	1.00	27.16	C
ATOM	107	CB	ARG		21	25.287	29.334	−27.500	1.00	30.22	C
ATOM	108	CG	ARG		21	25.969	30.212	−28.543	1.00	32.97	C
ATOM	109	CD	ARG		21	26.814	29.356	−29.471	1.00	35.32	C
ATOM	110	NE	ARG		21	26.099	28.152	−29.877	1.00	36.40	N
ATOM	111	CZ	ARG		21	25.252	28.079	−30.898	1.00	36.53	C
ATOM	112	NH1	ARG		21	25.001	29.144	−31.649	1.00	36.40	N
ATOM	113	NH2	ARG		21	24.646	26.931	−31.161	1.00	38.58	N
ATOM	114	C	ARG		21	24.332	31.254	−26.208	1.00	25.64	C
ATOM	115	O	ARG		21	23.099	31.222	−26.188	1.00	23.86	O
ATOM	116	N	VAL		22	25.022	32.382	−26.305	1.00	24.47	N
ATOM	117	CA	VAL		22	24.342	33.663	−26.391	1.00	24.25	C
ATOM	118	CB	VAL		22	25.330	34.837	−26.194	1.00	26.92	C
ATOM	119	CG1	VAL		22	26.036	34.709	−24.846	1.00	30.16	C
ATOM	120	CG2	VAL		22	26.347	34.859	−27.320	1.00	30.14	C
ATOM	121	C	VAL		22	23.644	33.833	−27.740	1.00	21.43	C
ATOM	122	O	VAL		22	24.064	33.278	−28.758	1.00	20.14	O
ATOM	123	N	TYR		23	22.551	34.581	−27.727	1.00	20.64	N
ATOM	124	CA	TYR		23	21.808	34.878	−28.943	1.00	18.29	C
ATOM	125	CB	TYR		23	20.758	33.803	−29.247	1.00	17.05	C
ATOM	126	CG	TYR		23	19.549	33.764	−28.335	1.00	19.03	C
ATOM	127	CD1	TYR		23	18.353	34.397	−28.694	1.00	19.87	C
ATOM	128	CE1	TYR		23	17.208	34.281	−27.902	1.00	21.13	C
ATOM	129	CD2	TYR		23	19.572	33.025	−27.156	1.00	22.01	C
ATOM	130	CE2	TYR		23	18.436	32.902	−26.357	1.00	23.35	C
ATOM	131	CZ	TYR		23	17.259	33.527	−26.736	1.00	23.29	C
ATOM	132	OH	TYR		23	16.133	33.361	−25.962	1.00	23.71	O
ATOM	133	C	TYR		23	21.155	36.219	−28.686	1.00	18.43	C
ATOM	134	O	TYR		23	21.283	36.771	−27.593	1.00	18.11	O
ATOM	135	N	TYR		24	20.472	36.754	−29.685	1.00	19.30	N
ATOM	136	CA	TYR		24	19.845	38.052	−29.521	1.00	19.78	C
ATOM	137	CB	TYR		24	20.540	39.077	−30.416	1.00	23.91	C
ATOM	138	CG	TYR		24	22.014	39.187	−30.104	1.00	27.74	C
ATOM	139	CD1	TYR		24	22.921	38.242	−30.590	1.00	29.88	C
ATOM	140	CE1	TYR		24	24.267	38.284	−30.233	1.00	32.47	C
ATOM	141	CD2	TYR		24	22.494	40.182	−29.253	1.00	29.73	C
ATOM	142	CE2	TYR		24	23.840	40.233	−28.888	1.00	33.45	C
ATOM	143	CZ	TYR		24	24.717	39.279	−29.382	1.00	34.29	C
ATOM	144	OH	TYR		24	26.044	39.314	−29.017	1.00	38.08	O
ATOM	145	C	TYR		24	18.364	37.983	−29.815	1.00	18.94	C
ATOM	146	O	TYR		24	17.929	37.263	−30.709	1.00	16.86	O
ATOM	147	N	PHE		25	17.601	38.734	−29.033	1.00	18.38	N
ATOM	148	CA	PHE		25	16.153	38.771	−29.145	1.00	19.81	C
ATOM	149	CB	PHE		25	15.542	38.147	−27.885	1.00	20.22	C
ATOM	150	CG	PHE		25	14.066	38.350	−27.758	1.00	20.32	C
ATOM	151	CD1	PHE		25	13.182	37.717	−28.631	1.00	22.39	C
ATOM	152	CD2	PHE		25	13.555	39.189	−26.771	1.00	20.95	C
ATOM	153	CE1	PHE		25	11.802	37.920	−28.522	1.00	23.14	C
ATOM	154	CE2	PHE		25	12.179	39.399	−26.653	1.00	22.17	C
ATOM	155	CZ	PHE		25	11.303	38.763	−27.532	1.00	22.96	C
ATOM	156	C	PHE		25	15.704	40.219	−29.279	1.00	19.13	C
ATOM	157	O	PHE		25	16.261	41.108	−28.632	1.00	20.48	O
ATOM	158	N	ASN		26	14.703	40.448	−30.124	1.00	17.74	N
ATOM	159	CA	ASN		26	14.155	41.790	−30.338	1.00	17.69	C
ATOM	160	CB	ASN		26	14.120	42.119	−31.834	1.00	16.86	C
ATOM	161	CG	ASN		26	13.696	43.552	−32.105	1.00	17.44	C
ATOM	162	OD1	ASN		26	12.601	43.971	−31.729	1.00	17.21	O
ATOM	163	ND2	ASN		26	14.565	44.310	−32.760	1.00	19.43	N
ATOM	164	C	ASN		26	12.742	41.780	−29.773	1.00	15.00	C
ATOM	165	O	ASN		26	11.885	41.044	−30.263	1.00	16.36	O
ATOM	166	N	HIS		27	12.496	42.594	−28.747	1.00	14.90	N
ATOM	167	CA	HIS		27	11.186	42.625	−28.099	1.00	15.79	C
ATOM	168	CB	HIS		27	11.317	43.144	−26.658	1.00	16.75	C
ATOM	169	CG	HIS		27	11.870	44.533	−26.558	1.00	20.66	C
ATOM	170	CD2	HIS		27	13.122	44.976	−26.297	1.00	20.21	C
ATOM	171	ND1	HIS		27	11.095	45.659	−26.741	1.00	24.85	N
ATOM	172	CE1	HIS		27	11.847	46.736	−26.596	1.00	23.42	C
ATOM	173	NE2	HIS		27	13.081	46.349	−26.328	1.00	24.68	N
ATOM	174	C	HIS		27	10.106	43.408	−28.837	1.00	16.49	C
ATOM	175	O	HIS		27	8.977	43.505	−28.361	1.00	17.21	O
ATOM	176	N	ILE		28	10.452	43.965	−29.992	1.00	16.77	N
ATOM	177	CA	ILE		28	9.480	44.701	−30.792	1.00	16.22	C
ATOM	178	CB	ILE		28	10.096	45.980	−31.395	1.00	17.94	C
ATOM	179	CG2	ILE		28	9.044	46.714	−32.239	1.00	16.31	C
ATOM	180	CG1	ILE		28	10.580	46.907	−30.276	1.00	17.14	C
ATOM	181	CD1	ILE		28	11.360	48.124	−30.781	1.00	18.58	C
ATOM	182	C	ILE		28	8.968	43.809	−31.926	1.00	17.18	C
ATOM	183	O	ILE		28	7.771	43.798	−32.226	1.00	17.90	O
ATOM	184	N	THR		29	9.871	43.043	−32.534	1.00	16.23	N
ATOM	185	CA	THR		29	9.516	42.147	−33.645	1.00	16.60	C
ATOM	186	CB	THR		29	10.587	42.162	−34.740	1.00	16.74	C
ATOM	187	OG1	THR		29	11.793	41.602	−34.203	1.00	16.47	O
ATOM	188	CG2	THR		29	10.865	43.580	−35.225	1.00	16.57	C
ATOM	189	C	THR		29	9.394	40.689	−33.212	1.00	16.39	C
ATOM	190	O	THR		29	8.880	39.852	−33.962	1.00	15.21	O
ATOM	191	N	ASN		30	9.883	40.391	−32.010	1.00	16.48	N
ATOM	192	CA	ASN		30	9.880	39.033	−31.474	1.00	15.89	C
ATOM	193	CB	ASN		30	8.449	38.478	−31.424	1.00	17.49	C
ATOM	194	CG	ASN		30	7.663	39.011	−30.230	1.00	19.11	C
ATOM	195	OD1	ASN		30	6.426	39.053	−30.241	1.00	19.17	O
ATOM	196	ND2	ASN		30	8.383	39.410	−29.186	1.00	15.19	N
ATOM	197	C	ASN		30	10.810	38.109	−32.264	1.00	15.49	C
ATOM	198	O	ASN		30	10.717	36.881	−32.175	1.00	14.57	O
ATOM	199	N	ALA		31	11.720	38.696	−33.035	1.00	14.85	N
ATOM	200	CA	ALA		31	12.679	37.886	−33.786	1.00	15.31	C
ATOM	201	CB	ALA		31	13.242	38.671	−34.964	1.00	14.57	C
ATOM	202	C	ALA		31	13.821	37.467	−32.863	1.00	16.03	C
ATOM	203	O	ALA		31	14.117	38.139	−31.876	1.00	15.69	O
ATOM	204	N	SER		32	14.453	36.343	−33.181	1.00	15.20	N
ATOM	205	CA	SER		32	15.589	35.868	−32.402	1.00	17.81	C
ATOM	206	CB	SER		32	15.152	34.816	−31.374	1.00	16.12	C
ATOM	207	OG	SER		32	14.361	33.801	−31.965	1.00	22.34	O
ATOM	208	C	SER		32	16.613	35.298	−33.378	1.00	18.35	C
ATOM	209	O	SER		32	16.249	34.626	−34.343	1.00	18.48	O
ATOM	210	N	GLN		33	17.887	35.590	−33.132	1.00	19.94	N
ATOM	211	CA	GLN		33	18.975	35.134	−33.999	1.00	21.00	C
ATOM	212	CB	GLN		33	19.227	36.179	−35.093	1.00	21.27	C
ATOM	213	CG	GLN		33	19.507	37.579	−34.535	1.00	26.19	C
ATOM	214	CD	GLN		33	19.799	38.613	−35.614	1.00	30.29	C
ATOM	215	OE1	GLN		33	18.997	38.825	−36.522	1.00	32.87	O
ATOM	216	NE2	GLN		33	20.953	39.265	−35.512	1.00	30.34	N
ATOM	217	C	GLN		33	20.265	34.930	−33.197	1.00	21.95	C
ATOM	218	O	GLN		33	20.433	35.512	−32.126	1.00	19.90	O
ATOM	219	N	TRP		34	21.183	34.124	−33.732	1.00	23.88	N
ATOM	220	CA	TRP		34	22.455	33.860	−33.058	1.00	22.59	C
ATOM	221	CB	TRP		34	23.123	32.600	−33.633	1.00	20.70	C
ATOM	222	CG	TRP		34	22.401	31.321	−33.325	1.00	19.59	C
ATOM	223	CD2	TRP		34	22.196	30.738	−32.031	1.00	20.78	C
ATOM	224	CE2	TRP		34	21.455	29.550	−32.221	1.00	21.49	C
ATOM	225	CE3	TRP		34	22.566	31.105	−30.729	1.00	21.77	C
ATOM	226	CD1	TRP		34	21.795	30.484	−34.221	1.00	21.09	C
ATOM	227	NE1	TRP		34	21.225	29.421	−33.565	1.00	20.42	N
ATOM	228	CZ2	TRP		34	21.073	28.725	−31.156	1.00	22.28	C
ATOM	229	CZ3	TRP		34	22.187	30.283	−29.668	1.00	23.47	C
ATOM	230	CH2	TRP		34	21.446	29.107	−29.891	1.00	24.65	C
ATOM	231	C	TRP		34	23.439	35.028	−33.143	1.00	24.82	C
ATOM	232	O	TRP		34	24.083	35.370	−32.152	1.00	23.87	O
ATOM	233	N	GLU		35	23.556	35.645	−34.317	1.00	28.44	N
ATOM	234	CA	GLU		35	24.488	36.756	−34.485	1.00	32.89	C
ATOM	235	CB	GLU		35	24.767	37.020	−35.962	1.00	34.03	C
ATOM	236	CG	GLU		35	25.382	35.862	−36.713	1.00	35.42	C
ATOM	237	CD	GLU		35	26.020	36.305	−38.014	1.00	35.75	C
ATOM	238	OE1	GLU		35	26.122	35.471	−38.935	1.00	35.53	O
ATOM	239	OE2	GLU		35	26.432	37.486	−38.106	1.00	35.56	O
ATOM	240	C	GLU		35	24.039	38.062	−33.857	1.00	36.99	C
ATOM	241	O	GLU		35	22.844	38.323	−33.713	1.00	35.51	O
ATOM	242	N	ARG		36	25.020	38.882	−33.490	1.00	40.29	N
ATOM	243	CA	ARG		36	24.751	40.182	−32.902	1.00	44.94	C
ATOM	244	CB	ARG		36	26.060	40.821	−32.430	1.00	45.80	C
ATOM	245	CG	ARG		36	25.897	41.845	−31.320	1.00	47.56	C
ATOM	246	CD	ARG		36	27.212	42.053	−30.584	1.00	49.01	C
ATOM	247	NE	ARG		36	27.039	42.819	−29.353	1.00	49.91	N
ATOM	248	CZ	ARG		36	26.760	44.117	−29.310	1.00	51.00	C
ATOM	249	NH1	ARG		36	26.625	44.809	−30.435	1.00	50.81	N
ATOM	250	NH2	ARG		36	26.611	44.723	−28.140	1.00	51.83	N
ATOM	251	C	ARG		36	24.124	40.987	−34.037	1.00	47.51	C
ATOM	252	O	ARG		36	24.741	41.183	−35.084	1.00	48.09	O
ATOM	253	N	PRO		37	22.882	41.456	−33.844	1.00	49.48	N
ATOM	254	CD	PRO		37	22.216	41.570	−32.536	1.00	49.60	C
ATOM	255	CA	PRO		37	22.160	42.233	−34.855	1.00	51.54	C
ATOM	256	CB	PRO		37	20.945	42.750	−34.087	1.00	50.70	C
ATOM	257	CG	PRO		37	21.456	42.861	−32.688	1.00	50.69	C
ATOM	258	C	PRO		37	22.961	43.354	−35.509	1.00	53.52	C
ATOM	259	O	PRO		37	23.708	44.075	−34.842	1.00	54.16	O
ATOM	260	N	SER		38	22.793	43.485	−36.822	1.00	55.71	N
ATOM	261	CA	SER		38	23.475	44.511	−37.604	1.00	57.41	C
ATOM	262	CB	SER		38	22.844	45.880	−37.333	1.00	57.75	C
ATOM	263	OG	SER		38	21.460	45.867	−37.637	1.00	58.08	O
ATOM	264	C	SER		38	24.969	44.565	−37.301	1.00	58.14	C
ATOM	265	O	SER		38	25.779	44.861	−38.181	1.00	59.14	O
ATOM	266	N	GLU		51	14.614	56.346	−39.127	1.00	53.04	N
ATOM	267	CA	GLU		51	13.987	55.185	−39.745	1.00	52.49	C
ATOM	268	CB	GLU		51	12.875	54.642	−38.844	1.00	52.96	C
ATOM	269	CG	GLU		51	11.632	55.517	−38.809	1.00	52.89	C
ATOM	270	CD	GLU		51	10.524	54.925	−37.962	1.00	52.81	C
ATOM	271	OE1	GLU		51	9.410	55.487	−37.969	1.00	51.84	O
ATOM	272	OE2	GLU		51	10.765	53.901	−37.287	1.00	53.59	O
ATOM	273	C	GLU		51	13.395	55.574	−41.098	1.00	51.96	C
ATOM	274	O	GLU		51	13.185	56.757	−41.373	1.00	52.52	O
ATOM	275	N	PRO		52	13.108	54.581	−41.958	1.00	50.63	N
ATOM	276	CD	PRO		52	13.211	53.126	−41.746	1.00	50.48	C
ATOM	277	CA	PRO		52	12.537	54.873	−43.275	1.00	48.30	C
ATOM	278	CB	PRO		52	12.508	53.503	−43.943	1.00	48.86	C
ATOM	279	CG	PRO		52	12.256	52.585	−42.787	1.00	48.97	C
ATOM	280	C	PRO		52	11.148	55.489	−43.157	1.00	46.35	C
ATOM	281	O	PRO		52	10.421	55.221	−42.201	1.00	46.27	O
ATOM	282	N	ALA		53	10.786	56.317	−44.129	1.00	43.75	N
ATOM	283	CA	ALA		53	9.482	56.960	−44.127	1.00	40.35	C
ATOM	284	CB	ALA		53	9.435	58.043	−45.192	1.00	42.00	C
ATOM	285	C	ALA		53	8.405	55.921	−44.391	1.00	37.97	C
ATOM	286	O	ALA		53	7.299	56.001	−43.856	1.00	36.28	O
ATOM	287	N	ARG		54	8.738	54.941	−45.224	1.00	35.90	N
ATOM	288	CA	ARG		54	7.802	53.881	−45.572	1.00	32.70	C
ATOM	289	CB	ARG		54	7.123	54.200	−46.906	1.00	35.72	C
ATOM	290	CG	ARG		54	6.361	55.516	−46.929	1.00	39.13	C
ATOM	291	CD	ARG		54	6.203	56.026	−48.354	1.00	42.35	C
ATOM	292	NE	ARG		54	5.461	55.100	−49.205	1.00	43.72	N
ATOM	293	CZ	ARG		54	4.174	54.810	−49.048	1.00	44.96	C
ATOM	294	NH1	ARG		54	3.479	55.374	−48.069	1.00	46.53	N
ATOM	295	NH2	ARG		54	3.581	53.962	−49.876	1.00	46.08	N
ATOM	296	C	ARG		54	8.514	52.540	−45.690	1.00	29.25	C
ATOM	297	O	ARG		54	9.726	52.477	−45.898	1.00	28.19	O
ATOM	298	N	VAL		55	7.748	51.468	−45.546	1.00	26.67	N
ATOM	299	CA	VAL		55	8.288	50.124	−45.675	1.00	24.08	C
ATOM	300	CB	VAL		55	8.558	49.455	−44.299	1.00	22.45	C
ATOM	301	CG1	VAL		55	9.473	50.325	−43.462	1.00	22.61	C
ATOM	302	CG2	VAL		55	7.245	49.189	−43.573	1.00	21.69	C
ATOM	303	C	VAL		55	7.260	49.282	−46.408	1.00	23.28	C
ATOM	304	O	VAL		55	6.081	49.634	−46.472	1.00	23.48	O
ATOM	305	N	ARG		56	7.716	48.176	−46.979	1.00	20.35	N
ATOM	306	CA	ARG		56	6.826	47.269	−47.673	1.00	18.76	C
ATOM	307	CB	ARG		56	7.222	47.125	−49.144	1.00	19.12	C
ATOM	308	CG	ARG		56	6.277	46.227	−49.917	1.00	21.28	C
ATOM	309	CD	ARG		56	6.693	46.081	−51.373	1.00	23.24	C
ATOM	310	NE	ARG		56	5.724	45.290	−52.130	1.00	24.12	N
ATOM	311	CZ	ARG		56	5.795	45.082	−53.442	1.00	25.74	C
ATOM	312	NH1	ARG		56	6.791	45.605	−54.145	1.00	25.07	N
ATOM	313	NH2	ARG		56	4.871	44.353	−54.052	1.00	22.75	N
ATOM	314	C	ARG		56	6.975	45.934	−46.963	1.00	18.38	C
ATOM	315	O	ARG		56	8.092	45.483	−46.708	1.00	17.93	O
ATOM	316	N	CYS		57	5.851	45.313	−46.630	1.00	17.73	N
ATOM	317	CA	CYS		57	5.872	44.033	−45.941	1.00	17.76	C
ATOM	318	CB	CYS		57	5.571	44.217	−44.448	1.00	17.32	C
ATOM	319	SG	CYS		57	6.751	45.199	−43.534	1.00	18.68	S
ATOM	320	C	CYS		57	4.849	43.063	−46.479	1.00	17.75	C
ATOM	321	O	CYS		57	3.862	43.450	−47.105	1.00	19.12	O
ATOM	322	N	SER		58	5.102	41.789	−46.215	1.00	16.21	N
ATOM	323	CA	SER		58	4.187	40.723	−46.562	1.00	15.73	C
ATOM	324	CB	SER		58	4.840	39.694	−47.489	1.00	15.00	C
ATOM	325	OG	SER		58	5.017	40.224	−48.787	1.00	16.34	O
ATOM	326	C	SER		58	3.954	40.103	−45.197	1.00	16.55	C
ATOM	327	O	SER		58	4.755	40.314	−44.276	1.00	15.97	O
ATOM	328	N	HIS		59	2.865	39.364	−45.042	1.00	15.13	N
ATOM	329	CA	HIS		59	2.615	38.725	−43.766	1.00	15.74	C
ATOM	330	CB	HIS		59	1.967	39.713	−42.776	1.00	17.79	C
ATOM	331	CG	HIS		59	0.485	39.873	−42.942	1.00	20.01	C
ATOM	332	CD2	HIS		59	−0.524	39.776	−42.043	1.00	20.23	C
ATOM	333	ND1	HIS		59	−0.106	40.191	−44.146	1.00	23.53	N
ATOM	334	CE1	HIS		59	−1.415	40.282	−43.983	1.00	20.29	C
ATOM	335	NE2	HIS		59	−1.694	40.036	−42.716	1.00	24.94	N
ATOM	336	C	HIS		59	1.758	37.483	−43.916	1.00	15.38	C
ATOM	337	O	HIS		59	1.115	37.254	−44.946	1.00	15.49	O
ATOM	338	N	LEU		60	1.790	36.660	−42.883	1.00	13.98	N
ATOM	339	CA	LEU		60	1.005	35.448	−42.844	1.00	14.87	C
ATOM	340	CB	LEU		60	1.916	34.224	−42.809	1.00	14.46	C
ATOM	341	CG	LEU		60	1.245	32.855	−42.956	1.00	15.20	C
ATOM	342	CD1	LEU		60	2.300	31.812	−43.313	1.00	16.63	C
ATOM	343	CD2	LEU		60	0.522	32.480	−41.668	1.00	16.52	C
ATOM	344	C	LEU		60	0.236	35.591	−41.545	1.00	16.69	C
ATOM	345	O	LEU		60	0.829	35.697	−40.469	1.00	14.62	O
ATOM	346	N	LEU		61	−1.087	35.620	−41.656	1.00	16.04	N
ATOM	347	CA	LEU		61	−1.949	35.776	−40.493	1.00	17.56	C
ATOM	348	CB	LEU		61	−3.006	36.854	−40.772	1.00	17.54	C
ATOM	349	CG	LEU		61	−4.111	37.017	−39.717	1.00	19.27	C
ATOM	350	CD1	LEU		61	−3.504	37.490	−38.397	1.00	20.49	C
ATOM	351	CD2	LEU		61	−5.145	38.019	−40.207	1.00	20.78	C
ATOM	352	C	LEU		61	−2.660	34.482	−40.127	1.00	16.44	C
ATOM	353	O	LEU		61	−3.180	33.782	−40.993	1.00	16.25	O
ATOM	354	N	VAL		62	−2.658	34.154	−38.838	1.00	16.65	N
ATOM	355	CA	VAL		62	−3.376	32.985	−38.365	1.00	17.17	C
ATOM	356	CB	VAL		62	−2.461	31.943	−37.700	1.00	18.11	C
ATOM	357	CG1	VAL		62	−3.313	30.817	−37.129	1.00	18.51	C
ATOM	358	CG2	VAL		62	−1.484	31.380	−38.717	1.00	18.42	C
ATOM	359	C	VAL		62	−4.341	33.545	−37.326	1.00	19.26	C
ATOM	360	O	VAL		62	−3.924	34.103	−36.307	1.00	16.64	O
ATOM	361	N	LYS		63	−5.633	33.434	−37.607	1.00	19.67	N
ATOM	362	CA	LYS		63	−6.637	33.950	−36.689	1.00	22.74	C
ATOM	363	CB	LYS		63	−7.897	34.372	−37.459	1.00	22.84	C
ATOM	364	CG	LYS		63	−7.720	35.615	−38.333	1.00	25.21	C
ATOM	365	CD	LYS		63	−9.057	36.064	−38.930	1.00	26.01	C
ATOM	366	CE	LYS		63	−8.921	37.343	−39.734	1.00	26.44	C
ATOM	367	NZ	LYS		63	−10.230	37.778	−40.315	1.00	28.10	N
ATOM	368	C	LYS		63	−6.997	32.903	−35.643	1.00	22.30	C
ATOM	369	O	LYS		63	−6.686	31.721	−35.796	1.00	21.61	O
ATOM	370	N	HIS		64	−7.639	33.351	−34.571	1.00	23.65	N
ATOM	371	CA	HIS		64	−8.071	32.454	−33.507	1.00	25.29	C
ATOM	372	CB	HIS		64	−7.049	32.439	−32.358	1.00	22.87	C
ATOM	373	CG	HIS		64	−6.606	33.798	−31.910	1.00	23.56	C
ATOM	374	CD2	HIS		64	−5.466	34.487	−32.154	1.00	22.70	C
ATOM	375	ND1	HIS		64	−7.373	34.604	−31.098	1.00	23.03	N
ATOM	376	CE1	HIS		64	−6.724	35.730	−30.859	1.00	25.33	C
ATOM	377	NE2	HIS		64	−5.564	35.684	−31.489	1.00	23.80	N
ATOM	378	C	HIS		64	−9.448	32.894	−33.021	1.00	26.27	C
ATOM	379	O	HIS		64	−9.968	33.916	−33.472	1.00	25.01	O
ATOM	380	N	SER		65	−10.035	32.122	−32.109	1.00	27.94	N
ATOM	381	CA	SER		65	−11.371	32.420	−31.593	1.00	29.00	C
ATOM	382	CB	SER		65	−11.789	31.355	−30.575	1.00	29.57	C
ATOM	383	CG	SER		65	−10.942	31.369	−29.440	1.00	32.41	O
ATOM	384	C	SER		65	−11.557	33.811	−30.984	1.00	30.15	C
ATOM	385	O	SER		65	−12.681	34.313	−30.926	1.00	30.15	O
ATOM	386	N	GLN		66	−10.474	34.438	−30.527	1.00	29.29	N
ATOM	387	CA	GLN		66	−10.585	35.772	−29.943	1.00	30.11	C
ATOM	388	CB	GLN		66	−9.696	35.904	−28.698	1.00	31.22	C
ATOM	389	CG	GLN		66	−10.186	35.118	−27.487	1.00	34.12	C
ATOM	390	CD	GLN		66	−9.496	35.542	−26.196	1.00	36.25	C
ATOM	391	OE1	GLN		66	−9.646	36.681	−25.738	1.00	34.02	O
ATOM	392	NE2	GLN		66	−8.731	34.627	−25.605	1.00	36.53	N
ATOM	393	C	GLN		66	−10.247	36.890	−30.925	1.00	29.93	C
ATOM	394	O	GLN		66	−10.202	38.061	−30.546	1.00	31.18	O
ATOM	395	N	SER		67	−10.005	36.538	−32.185	1.00	30.12	N
ATOM	396	CA	SER		67	−9.691	37.547	−33.191	1.00	29.93	C
ATOM	397	CB	SER		67	−9.318	36.886	−34.521	1.00	29.06	C
ATOM	398	OG	SER		67	−8.066	36.231	−34.434	1.00	26.26	O
ATOM	399	C	SER		67	−10.900	38.457	−33.392	1.00	31.50	C
ATOM	400	O	SER		67	−12.043	38.015	−33.266	1.00	31.79	O
ATOM	401	N	ARG		68	−10.639	39.724	−33.701	1.00	33.47	N
ATOM	402	CA	ARG		68	−11.701	40.703	−33.919	1.00	36.42	C
ATOM	403	CB	ARG		68	−11.123	41.964	−34.562	1.00	38.86	C
ATOM	404	CG	ARG		68	−11.507	43.258	−33.853	1.00	44.11	C
ATOM	405	CD	ARG		68	−11.086	43.235	−32.385	1.00	47.39	C
ATOM	406	NE	ARG		68	−11.236	44.538	−31.739	1.00	49.33	N
ATOM	407	CZ	ARG		68	−10.983	44.769	−30.454	1.00	50.65	C
ATOM	408	NH1	ARG		68	−10.568	43.782	−29.670	1.00	50.98	N
ATOM	409	NH2	ARG		68	−11.138	45.987	−29.952	1.00	51.60	N
ATOM	410	C	ARG		68	−12.800	40.125	−34.804	1.00	36.99	C
ATOM	411	O	ARG		68	−13.988	40.288	−34.522	1.00	38.05	O
ATOM	412	N	ARG		69	−12.398	39.447	−35.875	1.00	36.39	N
ATOM	413	CA	ARG		69	−13.343	38.828	−36.798	1.00	35.06	C
ATOM	414	CB	ARG		69	−13.391	39.617	−38.109	1.00	37.95	C
ATOM	415	CG	ARG		69	−14.489	39.177	−39.070	1.00	40.90	C
ATOM	416	CD	ARG		69	−14.596	40.125	−40.261	1.00	44.53	C
ATOM	417	NE	ARG		69	−13.477	40.000	−41.194	1.00	46.91	N
ATOM	418	CZ	ARG		69	−13.299	38.967	−42.013	1.00	47.74	C
ATOM	419	NH1	ARG		69	−14.168	37.963	−42.017	1.00	48.01	N
ATOM	420	NH2	ARG		69	−12.255	38.938	−42.831	1.00	47.70	N
ATOM	421	C	ARG		69	−12.878	37.397	−37.058	1.00	33.95	C
ATOM	422	O	ARG		69	−12.099	37.146	−37.980	1.00	33.71	O
ATOM	423	N	PRO		70	−13.348	36.440	−36.239	1.00	32.21	N
ATOM	424	CD	PRO		70	−14.265	36.640	−35.103	1.00	32.12	C
ATOM	425	CA	PRO		70	−12.982	35.024	−36.366	1.00	30.96	C
ATOM	426	CB	PRO		70	−13.549	34.410	−35.088	1.00	32.72	C
ATOM	427	CG	PRO		70	−14.768	35.240	−34.843	1.00	31.84	C
ATOM	428	C	PRO		70	−13.491	34.332	−37.626	1.00	29.75	C
ATOM	429	O	PRO		70	−14.186	33.314	−37.555	1.00	28.97	O
ATOM	430	N	SER		71	−13.122	34.880	−38.779	1.00	27.85	N
ATOM	431	CA	SER		71	−13.527	34.319	−40.064	1.00	26.65	C
ATOM	432	CB	SER		71	−14.913	34.848	−40.446	1.00	26.56	C
ATOM	433	OG	SER		71	−15.368	34.265	−41.654	1.00	28.18	O
ATOM	434	C	SER		71	−12.512	34.712	−41.137	1.00	25.86	C
ATOM	435	O	SER		71	−11.817	35.718	−40.997	1.00	26.08	O
ATOM	436	N	SER		72	−12.422	33.912	−42.197	1.00	24.98	N
ATOM	437	CA	SER		72	−11.503	34.198	−43.302	1.00	24.88	C
ATOM	438	CB	SER		72	−10.059	33.875	−42.913	1.00	22.69	C
ATOM	439	OG	SER		72	−9.833	32.478	−42.976	1.00	21.77	O
ATOM	440	C	SER		72	−11.875	33.358	−44.514	1.00	24.57	C
ATOM	441	O	SER		72	−12.752	32.499	−44.436	1.00	24.22	O
ATOM	442	N	TRP		73	−11.192	33.596	−45.630	1.00	25.35	N
ATOM	443	CA	TRP		73	−11.457	32.850	−46.851	1.00	25.09	C
ATOM	444	CB	TRP		73	−10.597	33.377	−48.012	1.00	24.73	C
ATOM	445	CG	TRP		73	−9.115	33.100	−47.871	1.00	24.60	C
ATOM	446	CD2	TRP		73	−8.406	31.953	−48.361	1.00	24.43	C
ATOM	447	CE2	TRP		73	−7.051	32.101	−47.978	1.00	23.41	C
ATOM	448	CE3	TRP		73	−8.784	30.811	−49.085	1.00	24.14	C
ATOM	449	CD1	TRP		73	−8.185	33.878	−47.229	1.00	24.29	C
ATOM	450	NE1	TRP		73	−6.945	33.282	−47.292	1.00	24.02	N
ATOM	451	CZ2	TRP		73	−6.074	31.151	−48.295	1.00	23.17	C
ATOM	452	CZ3	TRP		73	−7.806	29.862	−49.401	1.00	24.96	C
ATOM	453	CH2	TRP		73	−6.468	30.042	−49.003	1.00	24.47	C
ATOM	454	C	TRP		73	−11.183	31.360	−46.658	1.00	24.64	C
ATOM	455	O	TRP		73	−11.684	30.535	−47.417	1.00	24.77	O
ATOM	456	N	ARG		74	−10.391	31.017	−45.642	1.00	25.31	N
ATOM	457	CA	ARG		74	−10.056	29.621	−45.382	1.00	25.07	C
ATOM	458	CB	ARG		74	−8.772	29.520	−44.554	1.00	25.12	C
ATOM	459	CG	ARG		74	−7.568	30.213	−45.172	1.00	24.30	C
ATOM	460	CD	ARG		74	−6.288	29.655	−44.572	1.00	24.54	C
ATOM	461	NE	ARG		74	−6.157	28.243	−44.912	1.00	26.15	N
ATOM	462	CZ	ARG		74	−5.761	27.295	−44.073	1.00	27.56	C
ATOM	463	NH1	ARG		74	−5.447	27.596	−42.819	1.00	29.78	N
ATOM	464	NH2	ARG		74	−5.685	26.039	−44.490	1.00	30.29	N
ATOM	465	C	ARG		74	−11.173	28.857	−44.676	1.00	27.38	C
ATOM	466	O	ARG		74	−11.407	27.684	−44.966	1.00	27.18	O
ATOM	467	N	GLN		75	−11.843	29.512	−43.734	1.00	27.92	N
ATOM	468	CA	GLN		75	−12.945	28.879	−43.020	1.00	29.57	C
ATOM	469	CB	GLN		75	−12.431	27.971	−41.896	1.00	32.69	C
ATOM	470	CG	GLN		75	−11.581	28.656	−40.859	1.00	36.95	C
ATOM	471	CD	GLN		75	−11.155	27.720	−39.742	1.00	38.92	C
ATOM	472	OE1	GLN		75	−10.403	28.108	−38.851	1.00	40.52	O
ATOM	473	NE2	GLN		75	−11.641	26.482	−39.781	1.00	40.62	N
ATOM	474	C	GLN		75	−13.887	29.936	−42.466	1.00	28.89	C
ATOM	475	O	GLN		75	−13.459	30.935	−41.879	1.00	27.69	O
ATOM	476	N	GLU		76	−15.180	29.705	−42.663	1.00	27.66	N
ATOM	477	CA	GLU		76	−16.202	30.639	−42.231	1.00	26.40	C
ATOM	478	CB	GLU		76	−17.579	30.134	−42.667	1.00	26.47	C
ATOM	479	CG	GLU		76	−18.684	31.165	−42.528	1.00	26.91	C
ATOM	480	CD	GLU		76	−19.934	30.790	−43.315	1.00	27.18	C
ATOM	481	OE1	GLU		76	−20.872	31.614	−43.372	1.00	29.82	O
ATOM	482	OE2	GLU		76	−19.976	29.675	−43.877	1.00	25.98	O
ATOM	483	C	GLU		76	−16.198	30.916	−40.734	1.00	27.16	C
ATOM	484	O	GLU		76	−16.338	32.065	−40.317	1.00	25.65	O
ATOM	485	N	LYS		77	−16.044	29.870	−39.931	1.00	29.05	N
ATOM	486	CA	LYS		77	−16.029	30.022	−38.479	1.00	31.37	C
ATOM	487	CB	LYS		77	−17.160	29.200	−37.851	1.00	33.10	C
ATOM	488	CG	LYS		77	−17.319	29.402	−36.351	1.00	37.18	C
ATOM	489	CD	LYS		77	−18.448	28.545	−35.790	1.00	39.62	C
ATOM	490	CE	LYS		77	−18.664	28.807	−34.303	1.00	41.00	C
ATOM	491	NZ	LYS		77	−19.061	30.220	−34.031	1.00	42.21	N
ATOM	492	C	LYS		77	−14.689	29.570	−37.905	1.00	29.98	C
ATOM	493	O	LYS		77	−14.426	28.374	−37.801	1.00	30.91	O
ATOM	494	N	ILE		78	−13.844	30.530	−37.539	1.00	29.93	N
ATOM	495	CA	ILE		78	−12.534	30.218	−36.967	1.00	29.28	C
ATOM	496	CB	ILE		78	−11.571	31.416	−37.076	1.00	29.22	C
ATOM	497	CG2	ILE		78	−10.222	31.048	−36.462	1.00	27.44	C
ATOM	498	CG1	ILE		78	−11.429	31.855	−38.539	1.00	30.95	C
ATOM	499	CD1	ILE		78	−10.372	31.116	−39.325	1.00	30.51	C
ATOM	500	C	ILE		78	−12.728	29.906	−35.487	1.00	28.73	C
ATOM	501	O	ILE		78	−13.116	30.782	−34.715	1.00	29.60	O
ATOM	502	N	THR		79	−12.443	28.670	−35.091	1.00	28.73	N
ATOM	503	CA	THR		79	−12.621	28.270	−33.701	1.00	29.99	C
ATOM	504	CB	THR		79	−13.601	27.097	−33.607	1.00	30.94	C
ATOM	505	OG1	THR		79	−13.111	26.005	−34.393	1.00	33.62	O
ATOM	506	CG2	THR		79	−14.967	27.510	−34.121	1.00	32.21	C
ATOM	507	C	THR		79	−11.346	27.882	−32.948	1.00	30.42	C
ATOM	508	O	THR		79	−11.389	27.645	−31.737	1.00	30.20	O
ATOM	509	N	ARG		80	−10.216	27.809	−33.648	1.00	29.26	N
ATOM	510	CA	ARG		80	−8.969	27.438	−32.985	1.00	27.73	C
ATOM	511	CB	ARG		80	−7.810	27.389	−33.996	1.00	27.79	C
ATOM	512	CG	ARG		80	−7.412	28.737	−34.595	1.00	26.61	C
ATOM	513	CD	ARG		80	−6.092	28.621	−35.361	1.00	23.85	C
ATOM	514	NE	ARG		80	−6.234	27.895	−36.621	1.00	23.38	N
ATOM	515	CZ	ARG		80	−6.593	28.454	−37.775	1.00	21.95	C
ATOM	516	NH1	ARG		80	−6.846	29.755	−37.834	1.00	22.12	N
ATOM	517	NH2	ARG		80	−6.697	27.712	−38.873	1.00	22.26	N
ATOM	518	C	ARG		80	−8.653	28.423	−31.863	1.00	26.29	C
ATOM	519	O	ARG		80	−9.010	29.598	−31.936	1.00	27.24	O
ATOM	520	N	THR		81	−7.997	27.943	−30.811	1.00	26.49	N
ATOM	521	CA	THR		81	−7.650	28.810	−29.694	1.00	26.30	C
ATOM	522	CB	THR		81	−7.370	27.999	−28.413	1.00	27.36	C
ATOM	523	OG1	THR		81	−6.162	27.244	−28.572	1.00	27.30	O
ATOM	524	CG2	THR		81	−8.526	27.039	−28.131	1.00	28.20	C
ATOM	525	C	THR		81	−6.407	29.623	−30.025	1.00	26.40	C
ATOM	526	O	THR		81	−5.664	29.288	−30.946	1.00	24.80	O
ATOM	527	N	LYS		82	−6.193	30.695	−29.273	1.00	26.41	N
ATOM	528	CA	LYS		82	−5.028	31.547	−29.468	1.00	27.53	C
ATOM	529	CB	LYS		82	−5.030	32.666	−28.425	1.00	30.37	C
ATOM	530	CG	LYS		82	−3.857	33.630	−28.512	1.00	35.57	C
ATOM	531	CD	LYS		82	−4.015	34.773	−27.511	1.00	38.91	C
ATOM	532	CE	LYS		82	−4.170	34.248	−26.088	1.00	42.86	C
ATOM	533	NZ	LYS		82	−4.295	35.344	−25.089	1.00	44.49	N
ATOM	534	C	LYS		82	−3.768	30.693	−29.327	1.00	26.88	C
ATOM	535	O	LYS		82	−2.804	30.846	−30.077	1.00	24.49	O
ATOM	536	N	GLU		83	−3.788	29.780	−28.364	1.00	25.38	N
ATOM	537	CA	GLU		83	−2.651	28.903	−28.129	1.00	25.18	C
ATOM	538	CB	GLU		83	−2.901	28.040	−26.887	1.00	27.21	C
ATOM	539	CG	GLU		83	−2.947	28.836	−25.586	1.00	31.61	C
ATOM	540	CD	GLU		83	−4.190	29.708	−25.444	1.00	34.31	C
ATOM	541	OE1	GLU		83	−4.123	30.713	−24.702	1.00	37.68	O
ATOM	542	OE2	GLU		83	−5.235	29.387	−26.054	1.00	33.33	O
ATOM	543	C	GLU		83	−2.378	28.015	−29.339	1.00	23.21	C
ATOM	544	O	GLU		83	−1.222	27.786	−29.699	1.00	21.40	O
ATOM	545	N	GLU		84	−3.439	27.521	−29.973	1.00	22.12	N
ATOM	546	CA	GLU		84	−3.292	26.661	−31.146	1.00	22.54	C
ATOM	547	CB	GLU		84	−4.626	25.993	−31.500	1.00	24.78	C
ATOM	548	CG	GLU		84	−5.163	25.062	−30.422	1.00	29.89	C
ATOM	549	CD	GLU		84	−6.548	24.531	−30.749	1.00	31.60	C
ATOM	550	OE1	GLU		84	−7.454	25.355	−30.994	1.00	30.86	O
ATOM	551	OE2	GLU		84	−6.731	23.295	−30.759	1.00	33.98	O
ATOM	552	C	GLU		84	−2.799	27.487	−32.333	1.00	21.41	C
ATOM	553	O	GLU		84	−2.035	27.000	−33.170	1.00	20.63	O
ATOM	554	N	ALA		85	−3.242	28.736	−32.404	1.00	18.73	N
ATOM	555	CA	ALA		85	−2.813	29.622	−33.478	1.00	19.58	C
ATOM	556	CB	ALA		85	−3.558	30.950	−33.393	1.00	19.88	C
ATOM	557	C	ALA		85	−1.304	29.859	−33.360	1.00	20.03	C
ATOM	558	O	ALA		85	−0.582	29.842	−34.364	1.00	17.91	O
ATOM	559	N	LEU		86	−0.826	30.067	−32.135	1.00	18.83	N
ATOM	560	CA	LEU		86	0.599	30.309	−31.924	1.00	18.94	C
ATOM	561	CB	LEU		86	0.877	30.675	−30.457	1.00	17.95	C
ATOM	562	CG	LEU		86	2.325	31.013	−30.069	1.00	20.47	C
ATOM	563	CD1	LEU		86	2.874	32.114	−30.970	1.00	19.07	C
ATOM	564	CD2	LEU		86	2.373	31.465	−28.612	1.00	20.51	C
ATOM	565	C	LEU		86	1.436	29.101	−32.338	1.00	19.08	C
ATOM	566	O	LEU		86	2.513	29.254	−32.913	1.00	18.44	O
ATOM	567	N	GLU		87	0.953	27.895	−32.061	1.00	19.94	N
ATOM	568	CA	GLU		87	1.715	26.712	−32.445	1.00	22.10	C
ATOM	569	CB	GLU		87	1.104	25.455	−31.829	1.00	25.88	C
ATOM	570	CG	GLU		87	1.394	25.378	−30.343	1.00	33.91	C
ATOM	571	CD	GLU		87	2.850	25.708	−30.043	1.00	39.69	C
ATOM	572	OE1	GLU		87	3.737	24.957	−30.506	1.00	41.93	O
ATOM	573	OE2	GLU		87	3.109	26.726	−29.359	1.00	43.20	O
ATOM	574	C	GLU		87	1.833	26.572	−33.953	1.00	20.94	C
ATOM	575	O	GLU		87	2.866	26.130	−34.464	1.00	19.53	O
ATOM	576	N	LEU		88	0.781	26.953	−34.669	1.00	19.04	N
ATOM	577	CA	LEU		88	0.797	26.894	−36.123	1.00	18.20	C
ATOM	578	CB	LEU		88	−0.594	27.213	−36.678	1.00	17.83	C
ATOM	579	CG	LEU		88	−1.607	26.074	−36.543	1.00	21.08	C
ATOM	580	CD1	LEU		88	−3.026	26.594	−36.738	1.00	20.47	C
ATOM	581	CD2	LEU		88	−1.276	24.994	−37.563	1.00	21.11	C
ATOM	582	C	LEU		88	1.813	27.915	−36.629	1.00	16.72	C
ATOM	583	O	LEU		88	2.625	27.618	−37.507	1.00	17.60	O
ATOM	584	N	ILE		89	1.759	29.119	−36.068	1.00	16.37	N
ATOM	585	CA	ILE		89	2.688	30.185	−36.437	1.00	16.70	C
ATOM	586	CB	ILE		89	2.398	31.471	−35.619	1.00	17.17	C
ATOM	587	CG2	ILE		89	3.599	32.405	−35.637	1.00	15.46	C
ATOM	588	CG1	ILE		89	1.155	32.179	−36.174	1.00	16.85	C
ATOM	589	CD1	ILE		89	1.404	33.010	−37.442	1.00	14.20	C
ATOM	590	C	ILE		89	4.121	29.712	−36.174	1.00	17.79	C
ATOM	591	O	ILE		89	5.002	29.863	−37.026	1.00	14.51	O
ATOM	592	N	ASN		90	4.356	29.129	−35.002	1.00	17.52	N
ATOM	593	CA	ASN		90	5.700	28.657	−34.686	1.00	18.01	C
ATOM	594	CB	ASN		90	5.776	28.143	−33.244	1.00	19.64	C
ATOM	595	CG	ASN		90	5.750	29.264	−32.223	1.00	22.39	C
ATOM	596	OD1	ASN		90	6.215	30.374	−32.487	1.00	24.53	O
ATOM	597	ND2	ASN		90	5.227	28.974	−31.040	1.00	25.12	N
ATOM	598	C	ASN		90	6.158	27.577	−35.660	1.00	17.58	C
ATOM	599	O	ASN		90	7.330	27.528	−36.029	1.00	16.24	O
ATOM	600	N	GLY		91	5.231	26.725	−36.090	1.00	17.69	N
ATOM	601	CA	GLY		91	5.575	25.675	−37.032	1.00	16.76	C
ATOM	602	C	GLY		91	5.965	26.258	−38.379	1.00	17.49	C
ATOM	603	O	GLY		91	6.913	25.802	−39.023	1.00	16.71	O
ATOM	604	N	TYR		92	5.228	27.274	−38.818	1.00	15.08	N
ATOM	605	CA	TYR		92	5.523	27.922	−40.096	1.00	15.07	C
ATOM	606	CB	TYR		92	4.456	28.978	−40.419	1.00	14.21	C
ATOM	607	CG	TYR		92	3.069	28.410	−40.637	1.00	16.80	C
ATOM	608	CD1	TYR		92	1.933	29.150	−40.306	1.00	17.92	C
ATOM	609	CE1	TYR		92	0.653	28.633	−40.502	1.00	18.52	C
ATOM	610	CD2	TYR		92	2.890	27.136	−41.178	1.00	17.96	C
ATOM	611	CE2	TYR		92	1.615	26.610	−41.379	1.00	18.48	C
ATOM	612	CZ	TYR		92	0.503	27.365	−41.037	1.00	19.52	C
ATOM	613	OH	TYR		92	−0.762	26.848	−41.220	1.00	18.16	O
ATOM	614	C	TYR		92	6.890	28.592	−40.036	1.00	13.58	C
ATOM	615	O	TYR		92	7.672	28.521	−40.985	1.00	14.84	O
ATOM	616	N	ILE		93	7.182	29.242	−38.919	1.00	13.07	N
ATOM	617	CA	ILE		93	8.467	29.912	−38.774	1.00	12.46	C
ATOM	618	CB	ILE		93	8.555	30.685	−37.429	1.00	11.79	C
ATOM	619	CG2	ILE		93	9.997	31.142	−37.171	1.00	14.42	C
ATOM	620	CG1	ILE		93	7.622	31.907	−37.482	1.00	13.71	C
ATOM	621	CD1	ILE		93	7.620	32.762	−36.207	1.00	14.39	C
ATOM	622	C	ILE		93	9.601	28.900	−38.879	1.00	14.34	C
ATOM	623	O	ILE		93	10.611	29.156	−39.544	1.00	11.30	O
ATOM	624	N	GLN		94	9.426	27.743	−38.247	1.00	14.83	N
ATOM	625	CA	GLN		94	10.452	26.709	−38.293	1.00	17.56	C
ATOM	626	CB	GLN		94	10.071	25.510	−37.413	1.00	18.87	C
ATOM	627	CG	GLN		94	10.163	25.790	−35.922	1.00	22.84	C
ATOM	628	CD	GLN		94	9.911	24.556	−35.079	1.00	28.77	C
ATOM	629	OE1	GLN		94	8.900	23.872	−35.242	1.00	29.97	O
ATOM	630	NE2	GLN		94	10.831	24.266	−34.166	1.00	31.41	N
ATOM	631	C	GLN		94	10.695	26.238	−39.714	1.00	16.92	C
ATOM	632	O	GLN		94	11.841	26.064	−40.118	1.00	18.90	O
ATOM	633	N	LYS		95	9.623	26.038	−40.476	1.00	17.46	N
ATOM	634	CA	LYS		95	9.766	25.581	−41.850	1.00	17.51	C
ATOM	635	CB	LYS		95	8.409	25.152	−42.415	1.00	21.44	C
ATOM	636	CG	LYS		95	7.724	24.060	−41.607	1.00	27.33	C
ATOM	637	CD	LYS		95	6.521	23.491	−42.347	1.00	31.14	C
ATOM	638	CE	LYS		95	5.590	22.710	−41.412	1.00	35.50	C
ATOM	639	NZ	LYS		95	4.796	23.608	−40.505	1.00	33.20	N
ATOM	640	C	LYS		95	10.384	26.658	−42.739	1.00	16.47	C
ATOM	641	O	LYS		95	11.117	26.356	−43.682	1.00	17.74	O
ATOM	642	N	ILE		96	10.088	27.917	−42.449	1.00	15.01	N
ATOM	643	CA	ILE		96	10.647	28.998	−43.242	1.00	13.96	C
ATOM	644	CB	ILE		96	9.930	30.338	−42.939	1.00	14.06	C
ATOM	645	CG2	ILE		96	10.645	31.492	−43.639	1.00	13.12	C
ATOM	646	CG1	ILE		96	8.476	30.253	−43.420	1.00	13.74	C
ATOM	647	CD1	ILE		96	7.593	31.420	−42.981	1.00	17.05	C
ATOM	648	C	ILE		96	12.143	29.125	−42.954	1.00	12.71	C
ATOM	649	O	ILE		96	12.948	29.258	−43.873	1.00	13.62	O
ATOM	650	N	LYS		97	12.517	29.058	−41.682	1.00	13.77	N
ATOM	651	CA	LYS		97	13.926	29.187	−41.314	1.00	14.47	C
ATOM	652	CB	LYS		97	14.078	29.356	−39.796	1.00	13.38	C
ATOM	653	CG	LYS		97	13.716	30.752	−39.291	1.00	16.41	C
ATOM	654	CD	LYS		97	14.159	30.948	−37.846	1.00	15.94	C
ATOM	655	CE	LYS		97	14.098	32.413	−37.437	1.00	16.64	C
ATOM	656	NZ	LYS		97	14.566	32.624	−36.035	1.00	14.12	N
ATOM	657	C	LYS		97	14.785	28.023	−41.794	1.00	16.02	C
ATOM	658	O	LYS		97	15.965	28.210	−42.097	1.00	16.53	O
ATOM	659	N	SER		98	14.203	26.829	−41.869	1.00	15.75	N
ATOM	660	CA	SER		98	14.949	25.652	−42.331	1.00	17.11	C
ATOM	661	CB	SER		98	14.266	24.369	−41.856	1.00	17.57	C
ATOM	662	OG	SER		98	12.992	24.222	−42.460	1.00	17.95	O
ATOM	663	C	SER		98	15.065	25.616	−43.855	1.00	17.15	C
ATOM	664	O	SER		98	15.914	24.916	−44.413	1.00	17.05	O
ATOM	665	N	GLY		99	14.206	26.369	−44.530	1.00	16.27	N
ATOM	666	CA	GLY		99	14.238	26.381	−45.978	1.00	18.16	C
ATOM	667	C	GLY		99	13.358	25.298	−46.573	1.00	19.26	C
ATOM	668	O	GLY		99	13.287	25.158	−47.792	1.00	20.98	O
ATOM	669	N	GLU		100	12.684	24.533	−45.718	1.00	19.28	N
ATOM	670	CA	GLU		100	11.802	23.465	−46.179	1.00	22.63	C
ATOM	671	CB	GLU		100	11.232	22.691	−44.989	1.00	24.56	C
ATOM	672	CG	GLU		100	12.282	22.082	−44.080	1.00	34.69	C
ATOM	673	CD	GLU		100	11.709	21.629	−42.748	1.00	38.50	C
ATOM	674	OE1	GLU		100	12.500	21.310	−41.836	1.00	42.22	O
ATOM	675	OE2	GLU		100	10.468	21.589	−42.611	1.00	43.33	O
ATOM	676	C	GLU		100	10.657	24.071	−46.976	1.00	23.47	C
ATOM	677	O	GLU		100	10.177	23.482	−47.941	1.00	24.10	O
ATOM	678	N	GLU		101	10.227	25.259	−46.559	1.00	22.54	N
ATOM	679	CA	GLU		101	9.133	25.973	−47.211	1.00	25.17	C
ATOM	680	CB	GLU		101	7.845	25.804	−46.400	1.00	27.97	C
ATOM	681	CG	GLU		101	7.207	24.445	−46.523	1.00	32.58	C
ATOM	682	CD	GLU		101	6.336	24.348	−47.750	1.00	34.33	C
ATOM	683	OE1	GLU		101	6.783	24.781	−48.833	1.00	38.51	O
ATOM	684	OE2	GLU		101	5.203	23.840	−47.629	1.00	37.40	O
ATOM	685	C	GLU		101	9.466	27.450	−47.267	1.00	24.41	C
ATOM	686	O	GLU		101	10.126	27.962	−46.368	1.00	25.29	O
ATOM	687	N	ASP		102	9.037	28.149	−48.311	1.00	21.76	N
ATOM	688	CA	ASP		102	9.317	29.569	−48.312	1.00	23.85	C
ATOM	689	CB	ASP		102	9.811	30.069	−49.681	1.00	31.68	C
ATOM	690	CG	ASP		102	8.905	29.693	−50.818	1.00	36.62	C
ATOM	691	OD1	ASP		102	9.416	29.626	−51.962	1.00	40.04	O
ATOM	692	OD2	ASP		102	7.698	29.481	−50.585	1.00	40.03	O
ATOM	693	C	ASP		102	8.096	30.333	−47.821	1.00	20.96	C
ATOM	694	O	ASP		102	6.960	29.851	−47.887	1.00	18.92	O
ATOM	695	N	PHE		103	8.354	31.507	−47.272	1.00	17.56	N
ATOM	696	CA	PHE		103	7.308	32.356	−46.728	1.00	17.86	C
ATOM	697	CB	PHE		103	7.915	33.715	−46.359	1.00	17.46	C
ATOM	698	CG	PHE		103	6.910	34.720	−45.896	1.00	19.96	C
ATOM	699	CD1	PHE		103	6.575	34.821	−44.552	1.00	22.44	C
ATOM	700	CD2	PHE		103	6.242	35.521	−46.819	1.00	22.86	C
ATOM	701	CE1	PHE		103	5.586	35.698	−44.131	1.00	21.59	C
ATOM	702	CE2	PHE		103	5.247	36.403	−46.404	1.00	23.10	C
ATOM	703	CZ	PHE		103	4.921	36.487	−45.058	1.00	23.34	C
ATOM	704	C	PHE		103	6.128	32.551	−47.684	1.00	16.10	C
ATOM	705	O	PHE		103	4.964	32.406	−47.296	1.00	15.17	O
ATOM	706	N	GLU		104	6.433	32.878	−48.935	1.00	16.13	N
ATOM	707	CA	GLU		104	5.401	33.128	−49.934	1.00	17.66	C
ATOM	708	CB	GLU		104	6.046	33.514	−51.270	1.00	17.40	C
ATOM	709	CG	GLU		104	6.840	34.803	−51.203	1.00	18.94	C
ATOM	710	CD	GLU		104	8.293	34.596	−50.804	1.00	20.69	C
ATOM	711	OE1	GLU		104	8.616	33.564	−50.177	1.00	19.24	O
ATOM	712	OE2	GLU		104	9.114	35.484	−51.114	1.00	23.94	O
ATOM	713	C	GLU		104	4.438	31.971	−50.145	1.00	17.68	C
ATOM	714	O	GLU		104	3.228	32.183	−50.311	1.00	18.14	O
ATOM	715	N	SER		105	4.969	30.754	−50.142	1.00	17.65	N
ATOM	716	CA	SER		105	4.144	29.570	−50.339	1.00	19.62	C
ATOM	717	CB	SER		105	5.025	28.342	−50.557	1.00	21.10	C
ATOM	718	OG	SER		105	4.242	27.167	−50.592	1.00	24.46	O
ATOM	719	C	SER		105	3.210	29.330	−49.154	1.00	17.87	C
ATOM	720	O	SER		105	2.032	29.031	−49.339	1.00	16.82	O
ATOM	721	N	LEU		106	3.735	29.457	−47.939	1.00	17.50	N
ATOM	722	CA	LEU		106	2.915	29.252	−46.745	1.00	15.45	C
ATOM	723	CB	LEU		106	3.799	29.167	−45.491	1.00	14.63	C
ATOM	724	CG	LEU		106	4.794	27.998	−45.438	1.00	14.52	C
ATOM	725	CD1	LEU		106	5.587	28.048	−44.129	1.00	13.75	C
ATOM	726	CD2	LEU		106	4.055	26.679	−45.545	1.00	15.48	C
ATOM	727	C	LEU		106	1.881	30.370	−46.594	1.00	15.13	C
ATOM	728	O	LEU		106	0.766	30.126	−46.130	1.00	17.62	O
ATOM	729	N	ALA		107	2.236	31.592	−46.986	1.00	15.69	N
ATOM	730	CA	ALA		107	1.288	32.696	−46.890	1.00	16.19	C
ATOM	731	CB	ALA		107	1.967	34.019	−47.232	1.00	16.48	C
ATOM	732	C	ALA		107	0.120	32.440	−47.846	1.00	17.33	C
ATOM	733	O	ALA		107	−1.048	32.550	−47.457	1.00	17.01	O
ATOM	734	N	SER		108	0.436	32.093	−49.091	1.00	15.91	N
ATOM	735	CA	SER		108	−0.595	31.823	−50.092	1.00	17.16	C
ATOM	736	CB	SER		108	0.048	31.413	−51.420	1.00	16.68	C
ATOM	737	OG	SER		108	0.836	32.474	−51.937	1.00	21.71	O
ATOM	738	C	SER		108	−1.543	30.722	−49.642	1.00	18.11	C
ATOM	739	O	SER		108	−2.754	30.792	−49.857	1.00	18.16	O
ATOM	740	N	GLN		109	−0.982	29.705	−49.004	1.00	17.09	N
ATOM	741	CA	GLN		109	−1.762	28.569	−48.550	1.00	19.26	C
ATOM	742	CB	GLN		109	−0.863	27.341	−48.421	1.00	18.59	C
ATOM	743	CG	GLN		109	−0.352	26.765	−49.720	1.00	19.36	C
ATOM	744	CD	GLN		109	0.631	25.644	−49.472	1.00	22.99	C
ATOM	745	OE1	GLN		109	1.843	25.866	−49.372	1.00	24.27	O
ATOM	746	NE2	GLN		109	0.114	24.431	−49.345	1.00	21.44	N
ATOM	747	C	GLN		109	−2.506	28.712	−47.236	1.00	19.19	C
ATOM	748	O	GLN		109	−3.657	28.294	−47.125	1.00	19.84	O
ATOM	749	N	PHE		110	−1.859	29.309	−46.244	1.00	18.50	N
ATOM	750	CA	PHE		110	−2.459	29.366	−44.923	1.00	18.43	C
ATOM	751	CB	PHE		110	−1.590	28.535	−43.979	1.00	18.75	C
ATOM	752	CG	PHE		110	−1.240	27.185	−44.526	1.00	19.15	C
ATOM	753	CD1	PHE		110	0.075	26.869	−44.846	1.00	19.29	C
ATOM	754	CD2	PHE		110	−2.228	26.233	−44.743	1.00	19.69	C
ATOM	755	CE1	PHE		110	0.401	25.623	−45.373	1.00	21.20	C
ATOM	756	CE2	PHE		110	−1.913	24.985	−45.271	1.00	21.37	C
ATOM	757	CZ	PHE		110	−0.594	24.679	−45.587	1.00	20.98	C
ATOM	758	C	PHE		110	−2.781	30.686	−44.253	1.00	17.22	C
ATOM	759	O	PHE		110	−3.269	30.682	−43.125	1.00	19.14	O
ATOM	760	N	SER		111	−2.522	31.810	−44.904	1.00	16.53	N
ATOM	761	CA	SER		111	−2.827	33.083	−44.267	1.00	17.57	C
ATOM	762	CB	SER		111	−2.141	34.233	−44.992	1.00	14.46	C
ATOM	763	OG	SER		111	−2.384	35.459	−44.316	1.00	15.16	O
ATOM	764	C	SER		111	−4.336	33.329	−44.241	1.00	19.62	C
ATOM	765	O	SER		111	−5.016	33.178	−45.262	1.00	18.52	O
ATOM	766	N	ASP		112	−4.845	33.703	−43.069	1.00	19.75	N
ATOM	767	CA	ASP		112	−6.270	33.981	−42.881	1.00	21.92	C
ATOM	768	CB	ASP		112	−6.675	33.749	−41.418	1.00	20.75	C
ATOM	769	CG	ASP		112	−6.872	32.285	−41.091	1.00	22.18	C
ATOM	770	OD1	ASP		112	−7.569	31.594	−41.865	1.00	22.37	O
ATOM	771	OD2	ASP		112	−6.343	31.822	−40.054	1.00	21.73	O
ATOM	772	C	ASP		112	−6.623	35.412	−43.268	1.00	21.78	C
ATOM	773	O	ASP		112	−7.430	36.062	−42.603	1.00	22.89	O
ATOM	774	N	CYS		113	−6.009	35.898	−44.341	1.00	22.79	N
ATOM	775	CA	CYS		113	−6.242	37.249	−44.830	1.00	22.62	C
ATOM	776	CB	CYS		113	−5.086	38.163	−44.405	1.00	23.11	C
ATOM	777	SG	CYS		113	−5.361	39.937	−44.656	1.00	29.65	S
ATOM	778	C	CYS		113	−6.323	37.167	−46.352	1.00	22.79	C
ATOM	779	O	CYS		113	−5.710	36.289	−46.959	1.00	21.38	O
ATOM	780	N	SER		114	−7.076	38.073	−46.969	1.00	21.07	N
ATOM	781	CA	SER		114	−7.223	38.060	−48.421	1.00	21.83	C
ATOM	782	CB	SER		114	−8.277	39.083	−48.861	1.00	23.89	C
ATOM	783	OG	SER		114	−7.906	40.392	−48.473	1.00	30.53	O
ATOM	784	C	SER		114	−5.900	38.339	−49.132	1.00	20.35	C
ATOM	785	O	SER		114	−5.756	38.049	−50.320	1.00	19.83	O
ATOM	786	N	SER		115	−4.939	38.902	−48.405	1.00	19.00	N
ATOM	787	CA	SER		115	−3.627	39.196	−48.974	1.00	17.75	C
ATOM	788	CB	SER		115	−2.793	40.018	−47.989	1.00	18.12	C
ATOM	789	OG	SER		115	−2.762	39.383	−46.723	1.00	19.78	O
ATOM	790	C	SER		115	−2.897	37.897	−49.310	1.00	16.56	C
ATOM	791	O	SER		115	−1.845	37.918	−49.948	1.00	16.06	O
ATOM	792	N	ALA		116	−3.450	36.766	−48.877	1.00	14.44	N
ATOM	793	CA	ALA		116	−2.841	35.475	−49.174	1.00	13.90	C
ATOM	794	CB	ALA		116	−3.676	34.336	−48.577	1.00	16.29	C
ATOM	795	C	ALA		116	−2.758	35.313	−50.691	1.00	16.26	C
ATOM	796	O	ALA		116	−1.827	34.696	−51.206	1.00	14.48	O
ATOM	797	N	LYS		117	−3.734	35.883	−51.399	1.00	14.92	N
ATOM	798	CA	LYS		117	−3.785	35.792	−52.856	1.00	15.91	C
ATOM	799	CB	LYS		117	−5.109	36.367	−53.367	1.00	19.76	C
ATOM	800	CG	LYS		117	−6.325	35.632	−52.833	1.00	23.04	C
ATOM	801	CD	LYS		117	−6.439	34.249	−53.430	1.00	25.35	C
ATOM	802	CE	LYS		117	−7.560	33.448	−52.768	1.00	29.29	C
ATOM	803	NZ	LYS		117	−7.151	32.900	−51.437	1.00	25.83	N
ATOM	804	C	LYS		117	−2.611	36.489	−53.537	1.00	16.41	C
ATOM	805	O	LYS		117	−2.340	36.246	−54.714	1.00	14.80	O
ATOM	806	N	ALA		118	−1.927	37.355	−52.794	1.00	15.41	N
ATOM	807	CA	ALA		118	−0.756	38.067	−53.301	1.00	17.44	C
ATOM	808	CB	ALA		118	−0.950	39.575	−53.154	1.00	17.29	C
ATOM	809	C	ALA		118	0.494	37.624	−52.530	1.00	16.94	C
ATOM	810	O	ALA		118	1.398	38.423	−52.282	1.00	16.10	O
ATOM	811	N	ARG		119	0.536	36.351	−52.151	1.00	16.46	N
ATOM	812	CA	ARG		119	1.672	35.806	−51.405	1.00	18.38	C
ATOM	813	CB	ARG		119	2.941	35.835	−52.274	1.00	20.28	C
ATOM	814	CG	ARG		119	3.042	34.687	−53.274	1.00	25.13	C
ATOM	815	CD	ARG		119	3.989	34.993	−54.440	1.00	28.20	C
ATOM	816	NE	ARG		119	3.278	35.735	−55.475	1.00	36.50	N
ATOM	817	CZ	ARG		119	2.975	37.029	−55.408	1.00	36.48	C
ATOM	818	NH1	ARG		119	3.339	37.755	−54.358	1.00	39.04	N
ATOM	819	NH2	ARG		119	2.248	37.583	−56.365	1.00	33.05	N
ATOM	820	C	ARG		119	1.893	36.587	−50.113	1.00	17.79	C
ATOM	821	O	ARG		119	3.021	36.704	−49.625	1.00	17.25	O
ATOM	822	N	GLY		120	0.802	37.126	−49.573	1.00	17.12	N
ATOM	823	CA	GLY		120	0.858	37.877	−48.331	1.00	18.51	C
ATOM	824	C	GLY		120	1.296	39.326	−48.417	1.00	19.02	C
ATOM	825	O	GLY		120	1.308	40.024	−47.401	1.00	18.59	O
ATOM	826	N	ASP		121	1.639	39.792	−49.615	1.00	17.66	N
ATOM	827	CA	ASP		121	2.098	41.169	−49.796	1.00	17.66	C
ATOM	828	CB	ASP		121	2.584	41.376	−51.235	1.00	18.36	C
ATOM	829	CG	ASP		121	2.998	42.814	−51.512	1.00	20.32	C
ATOM	830	OD1	ASP		121	3.740	43.390	−50.691	1.00	18.59	O
ATOM	831	OD2	ASP		121	2.590	43.366	−52.556	1.00	20.54	O
ATOM	832	C	ASP		121	1.032	42.207	−49.462	1.00	18.64	C
ATOM	833	O	ASP		121	−0.108	42.107	−49.912	1.00	17.94	O
ATOM	834	N	LEU		122	1.420	43.203	−48.671	1.00	19.60	N
ATOM	835	CA	LEU		122	0.517	44.273	−48.262	1.00	21.00	C
ATOM	836	CB	LEU		122	0.586	44.469	−46.745	1.00	19.64	C
ATOM	837	CG	LEU		122	0.071	43.312	−45.890	1.00	18.59	C
ATOM	838	CD1	LEU		122	0.279	43.639	−44.423	1.00	19.00	C
ATOM	839	CD2	LEU		122	−1.394	43.067	−46.181	1.00	20.13	C
ATOM	840	C	LEU		122	0.849	45.594	−48.940	1.00	22.71	C
ATOM	841	O	LEU		122	0.142	46.585	−48.760	1.00	24.31	O
ATOM	842	N	GLY		123	1.926	45.611	−49.717	1.00	24.34	N
ATOM	843	CA	GLY		123	2.319	46.837	−50.382	1.00	24.39	C
ATOM	844	C	GLY		123	3.043	47.729	−49.394	1.00	26.20	C
ATOM	845	O	GLY		123	3.262	47.334	−48.244	1.00	26.42	O
ATOM	846	N	ALA		124	3.410	48.930	−49.829	1.00	24.94	N
ATOM	847	CA	ALA		124	4.127	49.865	−48.970	1.00	26.18	C
ATOM	848	CB	ALA		124	4.986	50.803	−49.821	1.00	25.26	C
ATOM	849	C	ALA		124	3.179	50.675	−48.094	1.00	27.33	C
ATOM	850	O	ALA		124	2.026	50.907	−48.454	1.00	28.10	O
ATOM	851	N	PHE		125	3.672	51.100	−46.937	1.00	27.49	N
ATOM	852	CA	PHE		125	2.867	51.892	−46.021	1.00	28.28	C
ATOM	853	CB	PHE		125	1.907	50.989	−45.230	1.00	28.12	C
ATOM	854	CG	PHE		125	2.592	49.926	−44.401	1.00	27.68	C
ATOM	855	CD1	PHE		125	3.148	50.234	−43.160	1.00	27.00	C
ATOM	856	CD2	PHE		125	2.665	48.612	−44.859	1.00	27.80	C
ATOM	857	CE1	PHE		125	3.765	49.247	−42.385	1.00	26.81	C
ATOM	858	CE2	PHE		125	3.280	47.617	−44.093	1.00	27.95	C
ATOM	859	CZ	PHE		125	3.831	47.936	−42.853	1.00	26.30	C
ATOM	860	C	PHE		125	3.749	52.695	−45.081	1.00	28.75	C
ATOM	861	O	PHE		125	4.948	52.431	−44.950	1.00	29.57	O
ATOM	862	N	SER		126	3.161	53.698	−44.444	1.00	30.25	N
ATOM	863	CA	SER		126	3.910	54.534	−43.518	1.00	31.30	C
ATOM	864	CB	SER		126	3.864	55.997	−43.976	1.00	33.33	C
ATOM	865	OG	SER		126	2.531	56.468	−44.008	1.00	33.44	O
ATOM	866	C	SER		126	3.284	54.394	−42.138	1.00	30.33	C
ATOM	867	O	SER		126	2.264	53.718	−41.980	1.00	29.25	O
ATOM	868	N	ARG		127	3.896	55.012	−41.136	1.00	31.04	N
ATOM	869	CA	ARG		127	3.343	54.935	−39.793	1.00	32.68	C
ATOM	870	CB	ARG		127	4.293	55.564	−38.768	1.00	31.89	C
ATOM	871	CG	ARG		127	5.498	54.699	−38.407	1.00	30.14	C
ATOM	872	CD	ARG		127	6.242	55.288	−37.222	1.00	29.33	C
ATOM	873	NE	ARG		127	7.395	54.495	−36.801	1.00	29.19	N
ATOM	874	CZ	ARG		127	7.329	53.386	−36.069	1.00	27.71	C
ATOM	875	NH1	ARG		127	6.159	52.914	−35.663	1.00	26.04	N
ATOM	876	NH2	ARG		127	8.446	52.757	−35.727	1.00	27.67	N
ATOM	877	C	ARG		127	2.005	55.660	−39.780	1.00	34.62	C
ATOM	878	O	ARG		127	1.810	56.634	−40.508	1.00	35.97	O
ATOM	879	N	GLY		128	1.081	55.168	−38.964	1.00	35.85	N
ATOM	880	CA	GLY		128	−0.229	55.783	−38.876	1.00	36.91	C
ATOM	881	C	GLY		128	−1.267	55.111	−39.755	1.00	37.54	C
ATOM	882	O	GLY		128	−2.316	55.692	−40.025	1.00	39.19	O
ATOM	883	N	GLN		129	−0.987	53.889	−40.202	1.00	35.80	N
ATOM	884	CA	GLN		129	−1.923	53.169	−41.059	1.00	35.32	C
ATOM	885	CB	GLN		129	−1.334	53.000	−42.468	1.00	36.78	C
ATOM	886	CG	GLN		129	−0.790	54.287	−43.094	1.00	38.82	C
ATOM	887	CD	GLN		129	−0.316	54.094	−44.531	1.00	39.29	C
ATOM	888	OE1	GLN		129	0.330	54.966	−45.108	1.00	41.53	O
ATOM	889	NE2	GLN		129	−0.646	52.951	−45.114	1.00	41.50	N
ATOM	890	C	GLN		129	−2.298	51.795	−40.503	1.00	35.11	C
ATOM	891	O	GLN		129	−3.471	51.427	−40.487	1.00	36.04	O
ATOM	892	N	MET		130	−1.301	51.043	−40.041	1.00	33.14	N
ATOM	893	CA	MET		130	−1.531	49.700	−39.509	1.00	31.66	C
ATOM	894	CB	MET		130	−0.364	48.786	−39.898	1.00	31.81	C
ATOM	895	CG	MET		130	−0.037	48.775	−41.379	1.00	32.58	C
ATOM	896	SD	MET		130	−1.345	48.040	−42.365	1.00	37.52	S
ATOM	897	CE	MET		130	−0.543	47.922	−43.967	1.00	34.65	C
ATOM	898	C	MET		130	−1.688	49.663	−37.989	1.00	30.84	C
ATOM	899	O	MET		130	−1.312	50.607	−37.296	1.00	31.94	O
ATOM	900	N	GLN		131	−2.243	48.567	−37.478	1.00	29.69	N
ATOM	901	CA	GLN		131	−2.397	48.405	−36.037	1.00	30.95	C
ATOM	902	CB	GLN		131	−2.945	47.015	−35.708	1.00	32.79	C
ATOM	903	CG	GLN		131	−4.378	46.796	−36.179	1.00	36.18	C
ATOM	904	CD	GLN		131	−4.953	45.467	−35.722	1.00	39.27	C
ATOM	905	OE1	GLN		131	−5.016	45.182	−34.526	1.00	41.41	O
ATOM	906	NE2	GLN		131	−5.376	44.648	−36.675	1.00	39.96	N
ATOM	907	C	GLN		131	−0.997	48.588	−35.458	1.00	30.83	C
ATOM	908	O	GLN		131	−0.018	48.084	−36.012	1.00	28.51	O
ATOM	909	N	LYS		132	−0.907	49.311	−34.348	1.00	29.13	N
ATOM	910	CA	LYS		132	0.375	49.618	−33.730	1.00	29.05	C
ATOM	911	CB	LYS		132	0.152	50.300	−32.379	1.00	29.79	C
ATOM	912	CG	LYS		132	1.290	51.221	−31.985	1.00	31.38	C
ATOM	913	CD	LYS		132	1.452	52.323	−33.017	1.00	33.54	C
ATOM	914	CE	LYS		132	2.483	53.358	−32.599	1.00	36.21	C
ATOM	915	NZ	LYS		132	3.865	52.825	−32.457	1.00	37.04	N
ATOM	916	C	LYS		132	1.387	48.477	−33.562	1.00	26.98	C
ATOM	917	O	LYS		132	2.559	48.645	−33.891	1.00	26.95	O
ATOM	918	N	PRO		133	0.961	47.316	−33.038	1.00	25.38	N
ATOM	919	CD	PRO		133	−0.350	46.934	−32.488	1.00	26.31	C
ATOM	920	CA	PRO		133	1.933	46.227	−32.879	1.00	25.07	C
ATOM	921	CB	PRO		133	1.096	45.101	−32.280	1.00	25.70	C
ATOM	922	CG	PRO		133	0.021	45.837	−31.526	1.00	26.89	C
ATOM	923	C	PRO		133	2.562	45.822	−34.214	1.00	24.98	C
ATOM	924	O	PRO		133	3.769	45.584	−34.302	1.00	23.26	O
ATOM	925	N	PHE		134	1.725	45.742	−35.243	1.00	23.09	N
ATOM	926	CA	PHE		134	2.166	45.367	−36.581	1.00	21.04	C
ATOM	927	CB	PHE		134	0.948	45.191	−37.489	1.00	19.46	C
ATOM	928	CG	PHE		134	1.261	44.548	−38.811	1.00	18.37	C
ATOM	929	CD1	PHE		134	1.127	43.171	−38.980	1.00	17.58	C
ATOM	930	CD2	PHE		134	1.704	45.313	−39.883	1.00	17.64	C
ATOM	931	CE1	PHE		134	1.433	42.564	−40.204	1.00	16.48	C
ATOM	932	CE2	PHE		134	2.012	44.719	−41.106	1.00	17.26	C
ATOM	933	CZ	PHE		134	1.877	43.343	−41.267	1.00	16.26	C
ATOM	934	C	PHE		134	3.072	46.464	−37.130	1.00	20.47	C
ATOM	935	O	PHE		134	4.143	46.193	−37.679	1.00	19.21	O
ATOM	936	N	GLU		135	2.643	47.713	−36.972	1.00	19.62	N
ATOM	937	CA	GLU		135	3.429	48.844	−37.444	1.00	19.53	C
ATOM	938	CB	GLU		135	2.720	50.162	−37.127	1.00	20.05	C
ATOM	939	CG	GLU		135	3.569	51.385	−37.428	1.00	23.50	C
ATOM	940	CD	GLU		135	2.907	52.678	−36.985	1.00	27.69	C
ATOM	941	OE1	GLU		135	1.792	52.965	−37.465	1.00	26.76	O
ATOM	942	OE2	GLU		135	3.506	53.401	−36.158	1.00	28.46	O
ATOM	943	C	GLU		135	4.819	48.868	−36.821	1.00	19.33	C
ATOM	944	O	GLU		135	5.826	48.954	−37.532	1.00	17.25	O
ATOM	945	N	ASP		136	4.879	48.807	−35.493	1.00	18.94	N
ATOM	946	CA	ASP		136	6.167	48.835	−34.802	1.00	17.95	C
ATOM	947	CB	ASP		136	5.973	48.771	−33.282	1.00	18.95	C
ATOM	948	CG	ASP		136	5.416	50.068	−32.705	1.00	22.69	C
ATOM	949	OD1	ASP		136	5.499	51.110	−33.388	1.00	21.20	O
ATOM	950	OD2	ASP		136	4.908	50.049	−31.566	1.00	22.27	O
ATOM	951	C	ASP		136	7.097	47.711	−35.249	1.00	15.96	C
ATOM	952	O	ASP		136	8.284	47.939	−35.482	1.00	15.72	O
ATOM	953	N	ALA		137	6.564	46.501	−35.367	1.00	16.06	N
ATOM	954	CA	ALA		137	7.379	45.367	−35.795	1.00	15.87	C
ATOM	955	CB	ALA		137	6.558	44.078	−35.743	1.00	15.26	C
ATOM	956	C	ALA		137	7.891	45.614	−37.216	1.00	15.35	C
ATOM	957	O	ALA		137	9.070	45.424	−37.503	1.00	16.28	O
ATOM	958	N	SER		138	7.001	46.060	−38.096	1.00	15.85	N
ATOM	959	CA	SER		138	7.366	46.325	−39.482	1.00	17.04	C
ATOM	960	CB	SER		138	6.158	46.832	−40.269	1.00	16.28	C
ATOM	961	OG	SER		138	5.146	45.847	−40.324	1.00	14.90	O
ATOM	962	C	SER		138	8.504	47.323	−39.628	1.00	19.07	C
ATOM	963	O	SER		138	9.438	47.084	−40.391	1.00	18.39	O
ATOM	964	N	PHE		139	8.429	48.442	−38.908	1.00	18.59	N
ATOM	965	CA	PHE		139	9.472	49.457	−38.999	1.00	20.09	C
ATOM	966	CB	PHE		139	8.938	50.824	−38.552	1.00	20.73	C
ATOM	967	CG	PHE		139	8.174	51.544	−39.626	1.00	21.76	C
ATOM	968	CD1	PHE		139	6.857	51.208	−39.908	1.00	22.50	C
ATOM	969	CD2	PHE		139	8.800	52.514	−40.408	1.00	22.93	C
ATOM	970	CE1	PHE		139	6.169	51.822	−40.958	1.00	22.33	C
ATOM	971	CE2	PHE		139	8.124	53.132	−41.458	1.00	22.59	C
ATOM	972	CZ	PHE		139	6.806	52.784	−41.733	1.00	20.81	C
ATOM	973	C	PHE		139	10.748	49.122	−38.241	1.00	20.34	C
ATOM	974	O	PHE		139	11.782	49.748	−38.467	1.00	22.50	O
ATOM	975	N	ALA		140	10.681	48.132	−37.355	1.00	19.71	N
ATOM	976	CA	ALA		140	11.853	47.719	−36.587	1.00	19.37	C
ATOM	977	CB	ALA		140	11.425	47.180	−35.231	1.00	18.59	C
ATOM	978	C	ALA		140	12.648	46.659	−37.351	1.00	19.95	C
ATOM	979	O	ALA		140	13.842	46.469	−37.107	1.00	19.76	O
ATOM	980	N	LEU		141	11.982	45.972	−38.274	1.00	19.78	N
ATOM	981	CA	LEU		141	12.637	44.953	−39.088	1.00	20.98	C
ATOM	982	CB	LEU		141	11.606	44.130	−39.871	1.00	19.49	C
ATOM	983	CG	LEU		141	10.740	43.130	−39.106	1.00	19.91	C
ATOM	984	CD1	LEU		141	9.622	42.623	−40.011	1.00	17.89	C
ATOM	985	CD2	LEU		141	11.609	41.975	−38.617	1.00	18.95	C
ATOM	986	C	LEU		141	13.576	45.602	−40.089	1.00	22.95	C
ATOM	987	O	LEU		141	13.316	46.706	−40.567	1.00	22.66	O
ATOM	988	N	ARG		142	14.673	44.918	−40.396	1.00	24.04	N
ATOM	989	CA	ARG		142	15.622	45.409	−41.382	1.00	25.12	C
ATOM	990	CB	ARG		142	17.020	44.849	−41.089	1.00	28.10	C
ATOM	991	CG	ARG		142	17.569	45.213	−39.700	1.00	29.80	C
ATOM	992	CD	ARG		142	18.970	44.637	−39.478	1.00	33.71	C
ATOM	993	NE	ARG		142	18.963	43.177	−39.413	1.00	35.33	N
ATOM	994	CZ	ARG		142	18.821	42.476	−38.292	1.00	36.74	C
ATOM	995	NH1	ARG		142	18.682	43.101	−37.132	1.00	35.28	N
ATOM	996	NH2	ARG		142	18.804	41.149	−38.334	1.00	35.75	N
ATOM	997	C	ARG		142	15.088	44.863	−42.710	1.00	25.76	C
ATOM	998	O	ARG		142	14.313	43.906	−42.714	1.00	24.03	O
ATOM	999	N	THR		143	15.476	45.462	−43.831	1.00	24.42	N
ATOM	1000	CA	THR		143	15.002	44.985	−45.125	1.00	24.26	C
ATOM	1001	CB	THR		143	15.547	45.842	−46.277	1.00	26.49	C
ATOM	1002	OG1	THR		143	15.077	47.185	−46.129	1.00	30.99	O
ATOM	1003	CG2	THR		143	15.078	45.299	−47.615	1.00	27.13	C
ATOM	1004	C	THR		143	15.437	43.540	−45.335	1.00	23.33	C
ATOM	1005	O	THR		143	16.618	43.221	−45.226	1.00	21.96	O
ATOM	1006	N	GLY		144	14.469	42.672	−45.619	1.00	21.58	N
ATOM	1007	CA	GLY		144	14.762	41.266	−45.828	1.00	19.98	C
ATOM	1008	C	GLY		144	14.558	40.414	−44.589	1.00	20.03	C
ATOM	1009	O	GLY		144	14.491	39.184	−44.678	1.00	20.32	O
ATOM	1010	N	GLU		145	14.449	41.064	−43.432	1.00	18.28	N
ATOM	1011	CA	GLU		145	14.275	40.363	−42.164	1.00	18.24	C
ATOM	1012	CB	GLU		145	14.798	41.236	−41.013	1.00	18.38	C
ATOM	1013	CG	GLU		145	14.567	40.646	−39.632	1.00	23.98	C
ATOM	1014	CD	GLU		145	15.205	41.458	−38.520	1.00	26.76	C
ATOM	1015	OE1	GLU		145	15.393	42.683	−38.704	1.00	25.29	O
ATOM	1016	OE2	GLU		145	15.505	40.869	−37.454	1.00	26.16	O
ATOM	1017	C	GLU		145	12.832	39.936	−41.879	1.00	17.64	C
ATOM	1018	O	GLU		145	11.876	40.569	−42.337	1.00	18.16	O
ATOM	1019	N	MET		146	12.691	38.853	−41.122	1.00	15.35	N
ATOM	1020	CA	MET		146	11.386	38.317	−40.762	1.00	15.06	C
ATOM	1021	CB	MET		146	11.276	36.855	−41.221	1.00	15.40	C
ATOM	1022	CG	MET		146	9.901	36.224	−41.019	1.00	14.97	C
ATOM	1023	SD	MET		146	9.864	34.522	−41.623	1.00	16.26	S
ATOM	1024	CE	MET		146	10.613	33.673	−40.228	1.00	15.69	C
ATOM	1025	C	MET		146	11.170	38.408	−39.252	1.00	14.21	C
ATOM	1026	O	MET		146	12.103	38.248	−38.456	1.00	12.74	O
ATOM	1027	N	SER		147	9.929	38.663	−38.861	1.00	13.22	N
ATOM	1028	CA	SER		147	9.595	38.789	−37.451	1.00	14.04	C
ATOM	1029	CB	SER		147	8.328	39.622	−37.285	1.00	12.58	C
ATOM	1030	OG	SER		147	7.197	38.817	−37.614	1.00	13.57	O
ATOM	1031	C	SER		147	9.308	37.438	−36.836	1.00	13.44	C
ATOM	1032	O	SER		147	9.272	36.422	−37.523	1.00	13.67	O
ATOM	1033	N	GLY		148	9.102	37.455	−35.524	1.00	15.04	N
ATOM	1034	CA	GLY		148	8.711	36.255	−34.812	1.00	15.40	C
ATOM	1035	C	GLY		148	7.204	36.441	−34.722	1.00	16.85	C
ATOM	1036	O	GLY		148	6.658	37.265	−35.461	1.00	16.08	O
ATOM	1037	N	PRO		149	6.495	35.714	−33.849	1.00	18.97	N
ATOM	1038	CD	PRO		149	6.939	34.580	−33.021	1.00	18.56	C
ATOM	1039	CA	PRO		149	5.038	35.899	−33.761	1.00	18.39	C
ATOM	1040	CB	PRO		149	4.605	34.809	−32.777	1.00	19.39	C
ATOM	1041	CG	PRO		149	5.681	33.748	−32.929	1.00	19.27	C
ATOM	1042	C	PRO		149	4.682	37.302	−33.254	1.00	19.10	C
ATOM	1043	O	PRO		149	5.177	37.729	−32.211	1.00	20.03	O
ATOM	1044	N	VAL		150	3.835	38.014	−33.996	1.00	16.13	N
ATOM	1045	CA	VAL		150	3.408	39.362	−33.609	1.00	15.88	C
ATOM	1046	CB	VAL		150	3.749	40.401	−34.700	1.00	14.93	C
ATOM	1047	CG1	VAL		150	3.159	41.762	−34.344	1.00	16.97	C
ATOM	1048	CG2	VAL		150	5.261	40.519	−34.838	1.00	16.68	C
ATOM	1049	C	VAL		150	1.897	39.328	−33.391	1.00	17.21	C
ATOM	1050	O	VAL		150	1.151	38.932	−34.279	1.00	16.07	O
ATOM	1051	N	PHE		151	1.459	39.738	−32.204	1.00	16.55	N
ATOM	1052	CA	PHE		151	0.042	39.715	−31.861	1.00	18.40	C
ATOM	1053	CB	PHE		151	−0.140	39.322	−30.385	1.00	18.03	C
ATOM	1054	CG	PHE		151	0.501	38.016	−30.013	1.00	18.94	C
ATOM	1055	CD1	PHE		151	1.881	37.919	−29.883	1.00	18.93	C
ATOM	1056	CD2	PHE		151	−0.275	36.883	−29.792	1.00	20.23	C
ATOM	1057	CE1	PHE		151	2.482	36.711	−29.537	1.00	20.92	C
ATOM	1058	CE2	PHE		151	0.317	35.667	−29.445	1.00	21.68	C
ATOM	1059	CZ	PHE		151	1.699	35.584	−29.318	1.00	22.21	C
ATOM	1060	C	PHE		151	−0.679	41.039	−32.095	1.00	18.85	C
ATOM	1061	O	PHE		151	−0.167	42.104	−31.752	1.00	20.63	O
ATOM	1062	N	THR		152	−1.863	40.962	−32.694	1.00	20.44	N
ATOM	1063	CA	THR		152	−2.699	42.142	−32.929	1.00	20.95	C
ATOM	1064	CB	THR		152	2.633	42.666	−34.378	1.00	19.75	C
ATOM	1065	OG1	THR		152	−3.235	41.704	−35.252	1.00	19.21	O
ATOM	1066	CG2	THR		152	−1.202	42.943	−34.798	1.00	21.65	C
ATOM	1067	C	THR		152	−4.129	41.680	−32.695	1.00	20.68	C
ATOM	1068	O	THR		152	−4.376	40.491	−32.496	1.00	18.54	O
ATOM	1069	N	ASP		153	−5.078	42.608	−32.735	1.00	23.80	N
ATOM	1070	CA	ASP		153	−6.468	42.234	−32.534	1.00	26.27	C
ATOM	1071	CB	ASP		153	−7.341	43.484	−32.390	1.00	29.45	C
ATOM	1072	CG	ASP		153	−7.015	44.275	−31.137	1.00	34.74	C
ATOM	1073	OD1	ASP		153	−6.820	43.639	−30.080	1.00	35.79	O
ATOM	1074	OD2	ASP		153	−6.960	45.524	−31.200	1.00	37.90	O
ATOM	1075	C	ASP		153	−6.985	41.353	−33.668	1.00	26.67	C
ATOM	1076	O	ASP		153	−8.004	40.678	−33.521	1.00	28.28	O
ATOM	1077	N	SER		154	−6.279	41.348	−34.798	1.00	23.94	N
ATOM	1078	CA	SER		154	−6.690	40.530	−35.934	1.00	22.63	C
ATOM	1079	CB	SER		154	−6.085	41.068	−37.234	1.00	24.28	C
ATOM	1080	OG	SER		154	−6.515	42.393	−37.482	1.00	28.47	O
ATOM	1081	C	SER		154	−6.268	39.077	−35.753	1.00	22.11	C
ATOM	1082	O	SER		154	−6.944	38.161	−36.230	1.00	21.34	O
ATOM	1083	N	GLY		155	−5.148	38.874	−35.063	1.00	19.10	N
ATOM	1084	CA	GLY		155	−4.649	37.528	−34.840	1.00	19.13	C
ATOM	1085	C	GLY		155	−3.145	37.535	−34.633	1.00	17.68	C
ATOM	1086	O	GLY		155	−2.593	38.516	−34.140	1.00	18.75	O
ATOM	1087	N	ILE		156	−2.479	36.447	−35.007	1.00	17.75	N
ATOM	1088	CA	ILE		156	−1.028	36.355	−34.851	1.00	16.35	C
ATOM	1089	CB	ILE		156	−0.627	35.044	−34.136	1.00	17.18	C
ATOM	1090	CG2	ILE		156	0.867	35.067	−33.793	1.00	17.57	C
ATOM	1091	CG1	ILE		156	−1.442	34.886	−32.844	1.00	18.69	C
ATOM	1092	CD1	ILE		156	−1.231	33.554	−32.149	1.00	18.75	C
ATOM	1093	C	ILE		156	−0.391	36.392	−36.241	1.00	16.94	C
ATOM	1094	O	ILE		156	−0.806	35.652	−37.141	1.00	16.38	O
ATOM	1095	N	HIS		157	0.620	37.244	−36.405	1.00	16.22	N
ATOM	1096	CA	HIS		157	1.289	37.406	−37.697	1.00	15.33	C
ATOM	1097	CB	HIS		157	1.263	38.870	−38.149	1.00	16.86	C
ATOM	1098	CG	HIS		157	−0.060	39.554	−38.004	1.00	19.00	C
ATOM	1099	CD2	HIS		157	−0.750	39.943	−36.906	1.00	19.48	C
ATOM	1100	ND1	HIS		157	−0.773	40.014	−39.090	1.00	18.92	N
ATOM	1101	CE1	HIS		157	−1.844	40.662	−38.666	1.00	20.43	C
ATOM	1102	NE2	HIS		157	−1.854	40.634	−37.345	1.00	18.30	N
ATOM	1103	C	HIS		157	2.772	37.034	−37.741	1.00	15.90	C
ATOM	1104	O	HIS		157	3.474	37.078	−36.733	1.00	16.36	O
ATOM	1105	N	ILE		158	3.226	36.697	−38.944	1.00	14.48	N
ATOM	1106	CA	ILE		158	4.635	36.466	−39.217	1.00	14.98	C
ATOM	1107	CB	ILE		158	4.934	35.115	−39.894	1.00	15.09	C
ATOM	1108	CG2	ILE		158	6.422	35.048	−40.245	1.00	16.74	C
ATOM	1109	CG1	ILE		158	4.586	33.959	−38.959	1.00	17.21	C
ATOM	1110	CD1	ILE		158	4.711	32.589	−39.623	1.00	15.82	C
ATOM	1111	C	ILE		158	4.807	37.575	−40.249	1.00	12.93	C
ATOM	1112	O	ILE		158	4.091	37.608	−41.250	1.00	14.94	O
ATOM	1113	N	ILE		159	5.729	38.495	−40.003	1.00	13.20	N
ATOM	1114	CA	ILE		159	5.925	39.612	−40.915	1.00	13.52	C
ATOM	1115	CB	ILE		159	5.823	40.959	−40.152	1.00	13.34	C
ATOM	1116	CG2	ILE		159	5.902	42.130	−41.131	1.00	13.88	C
ATOM	1117	CG1	ILE		159	4.507	41.008	−39.370	1.00	16.65	C
ATOM	1118	CD1	ILE		159	4.389	42.198	−38.423	1.00	14.49	C
ATOM	1119	C	ILE		159	7.276	39.545	−41.618	1.00	13.96	C
ATOM	1120	O	ILE		159	8.291	39.213	−41.007	1.00	14.96	O
ATOM	1121	N	LEU		160	7.276	39.850	−42.910	1.00	13.19	N
ATOM	1122	CA	LEU		160	8.510	39.848	−43.683	1.00	14.93	C
ATOM	1123	CB	LEU		160	8.455	38.787	−44.790	1.00	14.48	C
ATOM	1124	CG	LEU		160	9.654	38.749	−45.745	1.00	15.71	C
ATOM	1125	CD1	LEU		160	10.889	38.259	−44.997	1.00	16.43	C
ATOM	1126	CD2	LEU		160	9.356	37.833	−46.924	1.00	16.10	C
ATOM	1127	C	LEU		160	8.657	41.222	−44.311	1.00	15.40	C
ATOM	1128	O	LEU		160	7.807	41.636	−45.090	1.00	15.07	O
ATOM	1129	N	ARG		161	9.708	41.950	−43.955	1.00	17.20	N
ATOM	1130	CA	ARG		161	9.902	43.260	−44.560	1.00	18.43	C
ATOM	1131	CB	ARG		161	10.712	44.192	−43.660	1.00	18.62	C
ATOM	1132	CG	ARG		161	10.886	45.551	−44.311	1.00	21.13	C
ATOM	1133	CD	ARG		161	11.719	46.524	−43.501	1.00	23.54	C
ATOM	1134	NE	ARG		161	12.050	47.687	−44.322	1.00	24.30	N
ATOM	1135	CZ	ARG		161	12.967	48.595	−44.006	1.00	26.72	C
ATOM	1136	NH1	ARG		161	13.653	48.487	−42.874	1.00	26.00	N
ATOM	1137	NH2	ARG		161	13.217	49.600	−44.838	1.00	26.46	N
ATOM	1138	C	ARG		161	10.633	43.051	−45.879	1.00	18.60	C
ATOM	1139	O	ARG		161	11.733	42.493	−45.908	1.00	19.14	O
ATOM	1140	N	THR		162	10.016	43.492	−46.968	1.00	18.87	N
ATOM	1141	CA	THR		162	10.596	43.319	−48.293	1.00	20.27	C
ATOM	1142	CB	THR		162	9.534	42.823	−49.282	1.00	19.85	C
ATOM	1143	OG1	THR		162	8.442	43.750	−49.312	1.00	20.20	O
ATOM	1144	CG2	THR		162	9.018	41.447	−48.861	1.00	22.03	C
ATOM	1145	C	THR		162	11.251	44.576	−48.867	1.00	21.08	C
ATOM	1146	O	THR		162	12.066	44.483	−49.781	1.00	21.33	O
ATOM	1147	N	GLU		163	10.881	45.742	−48.341	1.00	22.73	N
ATOM	1148	CA	GLU		163	11.443	47.013	−48.798	1.00	24.59	C
ATOM	1149	CB	GLU		163	10.574	47.617	−49.908	1.00	26.38	C
ATOM	1150	CG	GLU		163	10.664	46.915	−51.252	1.00	27.57	C
ATOM	1151	CD	GLU		163	9.691	47.485	−52.277	1.00	29.28	C
ATOM	1152	OE1	GLU		163	9.265	48.651	−52.120	1.00	31.89	O
ATOM	1153	OE2	GLU		163	9.362	46.771	−53.247	1.00	30.85	O
ATOM	1154	C	GLU		163	11.521	47.998	−47.639	1.00	25.70	C
ATOM	1155	O	GLU		163	10.748	47.822	−46.679	1.00	25.93	O
ATOM	1156	OXT	GLU		163	12.333	48.946	−47.711	1.00	26.60	O
ATOM	1157	OH2	TIP	S	1	−3.169	46.912	−39.226	1.00	39.98	O
ATOM	1158	OH2	TIP	S	2	−9.187	43.900	−35.953	1.00	50.37	O
ATOM	1159	OH2	TIP	S	3	−9.804	41.479	−39.377	1.00	35.60	O
ATOM	1160	OH2	TIP	S	4	−9.694	39.156	−37.013	1.00	33.00	O
ATOM	1161	OH2	TIP	S	5	−10.351	40.786	−42.439	1.00	37.69	O
ATOM	1162	OH2	TIP	S	6	−9.828	37.555	−43.281	1.00	40.25	O
ATOM	1163	OH2	TIP	S	7	−9.134	39.541	−45.417	1.00	39.63	O
ATOM	1164	OH2	TIP	S	8	−9.883	36.059	−45.787	1.00	25.86	O
ATOM	1165	OH2	TIP	S	9	−11.183	37.138	−47.825	1.00	51.31	O
ATOM	1166	OH2	TIP	S	10	−13.134	37.200	−44.801	1.00	57.81	O
ATOM	1167	OH2	TIP	S	11	−13.681	36.911	−48.670	1.00	54.32	O
ATOM	1168	OH2	TIP	S	12	−2.662	45.936	−48.636	1.00	46.71	O
ATOM	1169	OH2	TIP	S	13	−2.729	42.968	−50.167	1.00	46.64	O
ATOM	1170	OH2	TIP	S	14	−6.847	39.305	−52.558	1.00	37.75	O
ATOM	1171	OH2	TIP	S	15	−2.348	50.877	−45.468	1.00	50.94	O
ATOM	1172	OH2	TIP	S	16	−0.027	49.396	−49.152	1.00	40.82	O
ATOM	1173	OH2	TIP	S	17	−3.752	45.286	−32.311	1.00	28.84	O
ATOM	1174	OH2	TIP	S	18	−5.994	47.670	−33.002	1.00	43.94	O
ATOM	1175	OH2	TIP	S	19	7.767	41.156	−27.330	1.00	16.45	O
ATOM	1176	OH2	TIP	S	20	−4.354	32.054	−51.696	1.00	20.07	O
ATOM	1177	OH2	TIP	S	21	5.998	42.383	−49.731	1.00	19.29	O
ATOM	1178	OH2	TIP	S	22	17.254	30.420	−41.338	1.00	16.42	O
ATOM	1179	OH2	TIP	S	23	−1.421	37.146	−45.955	1.00	19.88	O
ATOM	1180	OH2	TIP	S	24	15.467	44.230	−36.632	1.00	20.60	O
ATOM	1181	OH2	TIP	S	25	13.875	42.090	−35.571	1.00	18.18	O
ATOM	1182	OH2	TIP	S	26	−0.712	36.488	−56.932	1.00	16.98	O
ATOM	1183	OH2	TIP	S	27	5.199	38.069	−50.303	1.00	19.42	O
ATOM	1184	OH2	TIP	S	28	1.075	34.438	−56.473	1.00	24.74	O
ATOM	1185	OH2	TIP	S	29	12.785	30.169	−46.437	1.00	20.29	O
ATOM	1186	OH2	TIP	S	30	−3.063	27.789	−40.135	1.00	23.20	O
ATOM	1187	OH2	TIP	S	31	9.513	28.972	−34.350	1.00	20.46	O
ATOM	1188	OH2	TIP	S	32	1.531	52.084	−39.925	1.00	32.18	O
ATOM	1189	OH2	TIP	S	33	2.459	24.898	−38.457	1.00	21.37	O
ATOM	1190	OH2	TIP	S	34	−0.315	33.894	−53.978	1.00	23.30	O
ATOM	1191	OH2	TIP	S	35	17.426	32.582	−37.015	1.00	29.07	O
ATOM	1192	OH2	TIP	S	36	−8.210	28.942	−40.858	1.00	23.67	O
ATOM	1193	OH2	TIP	S	37	6.182	35.858	−29.883	1.00	28.85	O
ATOM	1194	OH2	TIP	S	38	5.369	45.061	−32.140	1.00	24.36	O
ATOM	1195	OH2	TIP	S	39	15.086	31.328	−31.812	1.00	24.42	O
ATOM	1196	OH2	TIP	S	40	−3.751	37.660	−31.387	1.00	25.58	O
ATOM	1197	OH2	TIP	S	41	−2.468	23.978	−49.241	1.00	29.30	O
ATOM	1198	OH2	TIP	S	42	25.659	33.768	−30.806	1.00	25.84	O
ATOM	1199	OH2	TIP	S	43	11.670	34.591	−31.049	1.00	24.04	O
ATOM	1200	OH2	TIP	S	44	14.925	35.721	−24.867	1.00	30.80	O
ATOM	1201	OH2	TIP	S	45	14.241	43.369	−22.021	1.00	28.12	O
ATOM	1202	OH2	TIP	S	46	−9.827	31.461	−52.317	1.00	28.97	O
ATOM	1203	OH2	TIP	S	47	8.506	31.396	−33.265	1.00	29.75	O
ATOM	1204	OH2	TIP	S	48	9.126	50.268	−34.499	1.00	27.86	O
ATOM	1205	OH2	TIP	S	49	16.265	29.480	−24.811	1.00	36.40	O
ATOM	1206	OH2	TIP	S	50	−4.553	29.804	−40.939	1.00	25.33	O
ATOM	1207	OH2	TIP	S	51	−0.925	24.231	−41.854	1.00	28.51	O
ATOM	1208	OH2	TIP	S	52	16.427	38.376	−37.205	1.00	27.04	O
ATOM	1209	OH2	TIP	S	53	−15.913	27.381	−43.840	1.00	32.30	O
ATOM	1210	OH2	TIP	S	54	11.447	51.458	−47.566	1.00	34.81	O
ATOM	1211	OH2	TIP	S	55	−20.434	33.968	−42.557	1.00	36.37	O
ATOM	1212	OH2	TIP	S	56	7.227	45.709	−28.080	1.00	36.73	O
ATOM	1213	OH2	TIP	S	57	−22.166	32.059	−45.749	1.00	40.49	O
ATOM	1214	OH2	TIP	S	58	5.903	56.632	−41.673	1.00	38.46	O
ATOM	1215	OH2	TIP	S	59	18.150	45.535	−36.175	1.00	37.77	O
ATOM	1216	OH2	TIP	S	60	8.999	50.903	−49.879	1.00	34.34	O
ATOM	1217	OH2	TIP	S	61	−6.750	26.968	−47.098	1.00	34.69	O
ATOM	1218	OH2	TIP	S	62	−18.643	27.480	−44.272	1.00	36.37	O
ATOM	1219	OH2	TIP	S	63	−16.785	27.296	−40.673	1.00	35.65	O
ATOM	1220	OH2	TIP	S	64	26.271	31.379	−32.412	1.00	29.61	O
ATOM	1221	OH2	TIP	S	65	−8.590	32.103	−28.199	1.00	38.48	O
ATOM	1222	OH2	TIP	S	66	−5.671	25.751	−26.645	1.00	37.50	O
ATOM	1223	OH2	TIP	S	67	−11.451	28.222	−48.868	1.00	29.77	O
ATOM	1224	OH2	TIP	S	68	4.742	24.437	−33.435	1.00	38.30	O
ATOM	1225	OH2	TIP	S	69	18.117	34.332	−21.727	1.00	41.86	O
ATOM	1226	OH2	TIP	S	70	20.729	36.831	−38.637	1.00	39.92	O
ATOM	1227	OH2	TIP	S	71	14.479	48.924	−39.242	1.00	39.55	O
ATOM	1228	OH2	TIP	S	72	−13.821	31.551	−48.959	1.00	42.01	O
ATOM	1229	OH2	TIP	S	73	15.590	47.645	−35.246	1.00	31.94	O
ATOM	1230	OH2	TIP	S	74	18.949	43.610	−43.728	1.00	48.26	O
ATOM	1231	OH2	TIP	S	75	18.097	37.022	−38.528	1.00	42.07	O
ATOM	1232	OH2	TIP	S	76	16.932	38.225	−22.164	1.00	41.10	O
ATOM	1233	OH2	TIP	S	77	11.113	32.143	−47.202	1.00	24.30	O
ATOM	1234	OH2	TIP	S	78	−10.315	27.244	−36.429	1.00	28.65	O
ATOM	1235	OH2	TIP	S	79	−1.936	24.324	−33.480	1.00	31.75	O
ATOM	1236	OH2	TIP	S	80	20.162	32.771	−36.255	1.00	28.51	O
ATOM	1237	OH2	TIP	S	81	13.968	36.749	−43.678	1.00	26.92	O
ATOM	1238	OH2	TIP	S	82	16.345	32.097	−23.691	1.00	32.88	O
ATOM	1239	OH2	TIP	S	83	22.857	26.185	−29.537	1.00	32.84	O
ATOM	1240	OH2	TIP	S	84	23.881	33.917	−38.501	1.00	31.97	O
ATOM	1241	OH2	TIP	S	85	22.284	34.994	−36.916	1.00	29.53	O
ATOM	1242	OH2	TIP	S	86	7.014	41.767	−52.154	1.00	26.98	O
ATOM	1243	OH2	TIP	S	87	0.812	23.273	−39.923	1.00	37.48	O
ATOM	1244	OH2	TIP	S	88	14.987	37.214	−40.593	1.00	31.15	O
ATOM	1245	OH2	TIP	S	89	−6.352	25.077	−36.593	1.00	33.45	O
ATOM	1246	OH2	TIP	S	90	2.764	27.501	−53.103	1.00	39.96	O
ATOM	1247	OH2	TIP	S	91	23.931	27.318	−33.585	1.00	39.51	O
ATOM	1248	OH2	TIP	S	92	20.844	42.905	−23.126	1.00	32.69	O
ATOM	1249	OH2	TIP	S	93	28.707	31.189	−31.305	1.00	39.90	O
ATOM	1250	OH2	TIP	S	94	28.032	31.973	−26.517	1.00	33.33	O
ATOM	1251	OH2	TIP	S	95	5.125	29.269	−28.102	1.00	41.09	O
ATOM	1252	OH2	TIP	S	96	1.538	42.594	−55.082	1.00	39.89	O
ATOM	1253	OH2	TIP	S	97	5.142	33.882	−28.543	1.00	29.65	O
ATOM	1254	OH2	TIP	S	98	7.522	37.819	−51.932	1.00	41.87	O
ATOM	1255	OH2	TIP	S	99	16.995	47.970	−43.596	1.00	45.54	O
ATOM	1256	OH2	TIP	S	100	3.386	31.577	−53.438	1.00	34.05	O
ATOM	1257	OH2	TIP	S	101	12.358	25.908	−32.630	1.00	43.09	O
ATOM	1258	OH2	TIP	S	102	−4.502	25.425	−40.148	1.00	39.44	O
ATOM	1259	OH2	TIP	S	103	2.326	23.321	−36.267	1.00	36.24	O
ATOM	1260	OH2	TIP	S	104	−3.840	42.854	−29.626	1.00	39.97	O
ATOM	1261	OH2	TIP	S	105	11.109	34.728	−28.256	1.00	39.02	O
ATOM	1262	OH2	TIP	S	106	−7.049	47.187	−29.149	1.00	46.19	O
ATOM	1263	OH2	TIP	S	107	8.696	50.838	−31.752	1.00	38.26	O
ATOM	1264	OH2	TIP	S	108	10.856	22.112	−32.337	1.00	41.15	O
ATOM	1265	OH2	TIP	S	109	1.975	22.619	−47.835	1.00	49.21	O
ATOM	1266	OH2	TIP	S	110	−17.209	33.537	−37.509	1.00	36.51	O
ATOM	1267	OH2	TIP	S	111	11.659	21.076	−49.137	1.00	53.87	O
ATOM	1268	OH2	TIP	S	112	14.223	45.759	−50.817	1.00	49.03	O
ATOM	1269	OH2	TIP	S	113	−15.401	31.484	−33.345	1.00	40.60	O
ATOM	1270	OH2	TIP	S	114	19.362	26.598	−28.612	1.00	48.37	O
ATOM	1271	OH2	TIP	S	115	7.431	49.367	−29.820	1.00	41.73	O
ATOM	1272	OH2	TIP	S	116	7.232	53.305	−50.896	1.00	53.94	O
ATOM	1273	OH2	TIP	S	117	−3.020	46.604	−30.113	1.00	48.72	O
ATOM	1274	OH2	TIP	S	118	12.385	34.632	−43.853	1.00	17.33	O
ATOM	1275	OH2	TIP	S	119	14.154	36.582	−37.742	1.00	24.77	O
ATOM	1276	OH2	TIP	S	120	4.908	47.446	−30.109	1.00	37.63	O
ATOM	1277	OH2	TIP	S	121	6.222	31.655	−29.384	1.00	25.17	O
ATOM	1278	OH2	TIP	S	122	6.936	34.872	−55.153	1.00	39.17	O
ATOM	1279	OH2	TIP	S	123	20.217	30.372	−37.400	1.00	38.24	O
ATOM	1280	OH2	TIP	S	124	5.893	30.640	−53.649	1.00	34.88	O
ATOM	1281	OH2	TIP	S	125	6.588	37.422	−54.426	1.00	36.59	O
ATOM	1282	OH2	TIP	S	126	−0.094	22.674	−34.881	1.00	44.41	O
ATOM	1283	OH2	TIP	S	127	10.378	27.577	−32.359	1.00	38.50	O
ATOM	1284	OH2	TIP	S	128	14.540	34.402	−40.444	1.00	39.48	O
ATOM	1285	OH2	TIP	S	129	4.496	50.788	−29.182	1.00	45.05	O
ATOM	1286	OH2	TIP	S	130	6.408	22.573	−35.459	1.00	50.43	O
ATOM	1287	OH2	TIP	S	131	−12.050	32.985	−51.422	1.00	48.91	O
ATOM	1288	OH2	TIP	S	132	−17.040	36.167	−37.739	1.00	37.60	O
ATOM	1289	OH2	TIP	S	133	−13.777	36.722	−31.648	1.00	43.95	O
ATOM	1290	OH2	TIP	S	134	−16.049	26.086	−37.549	1.00	51.05	O
ATOM	1291	OH2	TIP	S	135	27.742	35.447	−30.568	1.00	51.93	O
ATOM	1292	OH2	TIP	S	136	24.997	39.617	−38.777	1.00	47.11	O
ATOM	1293	OH2	TIP	S	137	0.185	35.562	−25.783	1.00	43.00	O
ATOM	1294	OH2	TIP	S	138	10.480	55.080	−33.160	1.00	52.31	O
ATOM	1295	OH2	TIP	S	139	14.051	20.534	−40.043	1.00	49.55	O
ATOM	1296	OH2	TIP	S	140	16.465	49.414	−47.240	1.00	48.94	O
ATOM	1297	OH2	TIP	S	141	8.955	32.884	−31.175	1.00	51.15	O
ATOM	1298	OH2	TIP	S	142	−22.281	28.847	−45.057	1.00	33.26	O
ATOM	1299	OH2	TIP	S	143	−15.182	33.251	−31.347	1.00	51.94	O
ATOM	1300	OH2	TIP	S	144	17.310	27.467	−31.346	1.00	47.32	O
ATOM	1301	OH2	TIP	S	145	12.427	30.220	−21.690	1.00	58.13	O
ATOM	1302	OH2	TIP	S	146	−14.089	24.436	−36.330	1.00	46.84	O
ATOM	1303	OH2	TIP	S	147	12.987	49.523	−26.982	1.00	52.33	O
ATOM	1304	OH2	TIP	S	148	23.820	28.870	−19.392	1.00	39.18	O
ATOM	1305	OH2	TIP	S	149	0.915	27.826	−28.160	1.00	39.66	O
ATOM	1306	OH2	TIP	S	150	18.428	50.726	−30.387	1.00	45.16	O
ATOM	1307	OH2	TIP	S	151	−4.284	23.686	−34.753	1.00	45.17	O
ATOM	1308	C2	L39	C	1	−2.384	44.155	−42.022	1.00	54.83	C
ATOM	1309	C3	L39	C	1	−3.652	43.539	−42.215	1.00	55.77	C
ATOM	1310	C4	L39	C	1	−4.432	43.115	−41.096	1.00	56.98	C
ATOM	1311	N7	L39	C	1	−5.646	42.528	−41.322	1.00	59.32	N
ATOM	1312	C11	L39	C	1	−6.837	43.079	−41.153	1.00	60.27	C
ATOM	1313	O13	L39	C	1	−7.095	44.327	−40.722	1.00	61.09	O
ATOM	1314	C10	L39	C	1	−7.807	42.215	−41.473	1.00	60.22	C
ATOM	1315	C9	L39	C	1	−7.073	41.014	−41.877	1.00	59.77	C
ATOM	1316	O12	L39	C	1	−7.656	39.884	−42.283	1.00	60.30	O
ATOM	1317	N8	L39	C	1	−5.834	41.263	−41.767	1.00	59.43	N
ATOM	1318	C5	L39	C	1	−3.920	43.317	−39.775	1.00	55.83	C
ATOM	1319	C6	L39	C	1	−2.649	43.934	−39.584	1.00	54.82	C
ATOM	1320	C1	L39	C	1	−1.882	44.353	−40.707	1.00	53.88	C
ATOM	1321	O1	PGA	B	180	13.247	35.091	−35.643	1.00	21.80	O
ATOM	1322	C2	PGA	B	180	11.924	34.755	−35.651	1.00	24.34	C
ATOM	1323	C3	PGA	B	180	11.610	33.748	−34.528	1.00	24.78	C
ATOM	1324	O4	PGA	B	180	12.151	32.559	−34.792	1.00	22.53	O
ATOM	1325	C5	PGA	B	180	11.898	31.671	−33.831	1.00	22.49	C
ATOM	1326	C6	PGA	B	180	12.544	30.309	−34.175	1.00	22.18	C
ATOM	1327	O7	PGA	B	180	13.877	30.454	−34.380	1.00	24.17	O
ATOM	1328	C8	PGA	B	180	14.479	29.277	−34.663	1.00	24.81	C
ATOM	1329	C9	PGA	B	180	15.994	29.488	−34.895	1.00	24.23	C
ATOM	1330	O10	PGA	B	180	16.536	30.250	−33.902	1.00	27.21	O
ATOM	1331	C11	PGA	B	180	17.856	30.454	−34.084	1.00	28.90	C
ATOM	1332	C12	PGA	B	180	18.444	31.209	−32.871	1.00	27.39	C
ATOM	1333	O13	PGA	B	180	18.015	30.654	−31.729	1.00	30.53	O
ATOM	1334	C14	PGA	B	180	18.516	31.303	−30.677	1.00	30.71	C
ATOM	1335	C15	PGA	B	180	18.002	30.670	−29.361	1.00	33.11	C
ATOM	1336	O16	PGA	B	180	16.748	30.193	−29.474	1.00	37.48	O
ATOM	1337	C17	PGA	B	180	15.996	30.910	−28.700	1.00	39.27	C
ATOM	1338	C18	PGA	B	180	14.536	30.484	−28.727	1.00	42.26	C
ATOM	1339	O19	PGA	B	180	13.881	31.280	−27.919	1.00	43.72

[0200] Pin1 R14A/Citrate/Glycerol Interactions

[0201] The crystal structure of Pin1 crystallized in the presence of citrate and glycerol was determined (the coordinate set is set forth in Table 6). The citrate molecule binds in the phosphate pocket, making interactions with Lys63 and Arg69. Glycerol binds in the hydrophobic pocket, hydrogen bonding with Gln131.

TABLE 6
Set of atomic coordinates of Pin1 R14A with glycerol and citrate bound in the active site.
ATOM	1	CB	LYS		6	55.445	2.509	−80.998	1.00	98.16	C
ATOM	2	CG	LYS		6	54.950	2.240	−79.586	1.00	98.85	C
ATOM	3	CD	LYS		6	56.005	2.620	−78.561	1.00	99.89	C
ATOM	4	CE	LYS		6	55.563	2.261	−77.154	1.00	100.16	C
ATOM	5	NZ	LYS		6	56.604	2.603	−76.147	1.00	100.86	N
ATOM	6	C	LYS		6	53.285	2.961	−82.191	1.00	81.57	C
ATOM	7	O	LYS		6	52.898	3.595	−81.208	1.00	82.16	O
ATOM	8	N	LYS		6	55.211	1.998	−83.407	1.00	82.24	N
ATOM	9	CA	LYS		6	54.496	2.033	−82.101	1.00	82.23	C
ATOM	10	N	LEU		7	52.707	3.027	−83.390	1.00	65.96	N
ATOM	11	CA	LEU		7	51.528	3.839	−83.692	1.00	64.20	C
ATOM	12	CB	LEU		7	50.571	3.887	−82.490	1.00	54.94	C
ATOM	13	CG	LEU		7	49.984	2.559	−82.002	1.00	54.86	C
ATOM	14	CD1	LEU		7	48.929	2.824	−80.938	1.00	55.00	C
ATOM	15	CD2	LEU		7	49.375	1.810	−83.173	1.00	54.83	C
ATOM	16	C	LEU		7	51.835	5.262	−84.148	1.00	62.41	C
ATOM	17	O	LEU		7	52.450	6.044	−83.424	1.00	62.15	O
ATOM	18	N	PRO		8	51.400	5.609	−85.369	1.00	59.55	N
ATOM	19	CD	PRO		8	50.791	4.670	−86.324	1.00	56.96	C
ATOM	20	CA	PRO		8	51.585	6.923	−85.990	1.00	57.77	C
ATOM	21	CB	PRO		8	50.850	6.775	−87.320	1.00	55.92	C
ATOM	22	CG	PRO		8	51.068	5.344	−87.650	1.00	56.52	C
ATOM	23	C	PRO		8	51.006	8.042	−85.125	1.00	56.10	C
ATOM	24	O	PRO		8	50.390	7.785	−84.086	1.00	55.67	O
ATOM	25	N	PRO		9	51.192	9.301	−85.550	1.00	53.27	N
ATOM	26	CD	PRO		9	51.939	9.704	−86.755	1.00	43.20	C
ATOM	27	CA	PRO		9	50.702	10.477	−84.827	1.00	49.97	C
ATOM	28	CB	PRO		9	51.038	11.630	−85.774	1.00	41.41	C
ATOM	29	CG	PRO		9	52.285	11.147	−86.451	1.00	43.41	C
ATOM	30	C	PRO		9	49.222	10.449	−84.475	1.00	44.98	C
ATOM	31	O	PRO		9	48.366	10.388	−85.359	1.00	45.29	O
ATOM	32	N	GLY		10	48.933	10.496	−83.177	1.00	43.90	N
ATOM	33	CA	GLY		10	47.553	10.516	−82.724	1.00	37.61	C
ATOM	34	C	GLY		10	46.870	9.195	−82.406	1.00	32.29	C
ATOM	35	O	GLY		10	45.769	9.200	−81.858	1.00	28.79	O
ATOM	36	N	TRP		11	47.501	8.074	−82.739	1.00	43.59	N
ATOM	37	CA	TRP		11	46.898	6.769	−82.481	1.00	42.04	C
ATOM	38	CB	TRP		11	47.348	5.747	−83.531	1.00	33.82	C
ATOM	39	CG	TRP		11	46.829	6.004	−84.911	1.00	32.29	C
ATOM	40	CD2	TRP		11	45.526	5.669	−85.417	1.00	31.33	C
ATOM	41	CE2	TRP		11	45.484	6.081	−86.766	1.00	30.36	C
ATOM	42	CE3	TRP		11	44.396	5.062	−84.860	1.00	28.35	C
ATOM	43	CD1	TRP		11	47.498	6.590	−85.940	1.00	32.31	C
ATOM	44	NE1	TRP		11	46.699	6.640	−87.059	1.00	31.61	N
ATOM	45	CZ2	TRP		11	44.358	5.906	−87.570	1.00	28.84	C
ATOM	46	CZ3	TRP		11	43.271	4.889	−85.662	1.00	27.55	C
ATOM	47	CH2	TRP		11	43.262	5.309	−87.003	1.00	28.50	C
ATOM	48	C	TRP		11	47.193	6.198	−81.101	1.00	41.92	C
ATOM	49	O	TRP		11	48.302	6.320	−80.584	1.00	41.10	O
ATOM	50	N	GLU		12	46.184	5.565	−80.515	1.00	34.93	N
ATOM	51	CA	GLU		12	46.313	4.929	−79.209	1.00	33.99	C
ATOM	52	CB	GLU		12	45.706	5.807	−78.109	1.00	69.08	C
ATOM	53	CG	GLU		12	44.192	5.964	−78.208	1.00	71.07	C
ATOM	54	CD	GLU		12	43.579	6.614	−76.978	1.00	72.99	C
ATOM	55	OE1	GLU		12	43.981	7.745	−76.630	1.00	72.29	O
ATOM	56	OE2	GLU		12	42.691	5.991	−76.359	1.00	73.29	O
ATOM	57	C	GLU		12	45.560	3.598	−79.265	1.00	32.93	C
ATOM	58	O	GLU		12	44.650	3.420	−80.076	1.00	31.05	O
ATOM	59	N	LYS		13	45.940	2.664	−78.404	1.00	38.02	N
ATOM	60	CA	LYS		13	45.275	1.374	−78.364	1.00	39.73	C
ATOM	61	CB	LYS		13	46.208	0.321	−77.763	1.00	65.15	C
ATOM	62	CG	LYS		13	45.730	−1.110	−77.923	1.00	68.38	C
ATOM	63	CD	LYS		13	46.538	−2.055	−77.042	1.00	70.78	C
ATOM	64	CE	LYS		13	48.032	−1.962	−77.330	1.00	71.66	C
ATOM	65	NZ	LYS		13	48.848	−2.730	−76.337	1.00	72.97	N
ATOM	66	C	LYS		13	44.046	1.550	−77.483	1.00	39.24	C
ATOM	67	O	LYS		13	44.083	2.281	−76.494	1.00	38.03	O
ATOM	68	N	ALA		14	42.950	0.899	−77.848	1.00	33.96	N
ATOM	69	CA	ALA		14	41.730	1.006	−77.064	1.00	34.14	C
ATOM	70	CB	ALA		14	40.778	2.002	−77.707	1.00	30.95	C
ATOM	71	C	ALA		14	41.045	−0.343	−76.903	1.00	33.37	C
ATOM	72	O	ALA		14	41.356	−1.310	−77.602	1.00	31.73	O
ATOM	73	N	MET		15	40.101	−0.390	−75.977	1.00	34.01	N
ATOM	74	CA	MET		15	39.360	−1.606	−75.696	1.00	34.17	C
ATOM	75	CB	MET		15	39.486	−1.946	−74.208	1.00	48.76	C
ATOM	76	CG	MET		15	38.650	−3.131	−73.784	1.00	51.61	C
ATOM	77	SD	MET		15	39.016	−4.532	−74.824	1.00	55.30	S
ATOM	78	CE	MET		15	40.517	−5.143	−74.033	1.00	53.03	C
ATOM	79	C	MET		15	37.888	−1.459	−76.068	1.00	33.51	C
ATOM	80	O	MET		15	37.201	−0.579	−75.564	1.00	31.33	O
ATOM	81	N	SER		16	37.409	−2.319	−76.958	1.00	30.37	N
ATOM	82	CA	SER		16	36.008	−2.273	−77.365	1.00	29.84	C
ATOM	83	CB	SER		16	35.761	−3.206	−78.546	1.00	34.48	C
ATOM	84	OG	SER		16	34.369	−3.381	−78.743	1.00	35.56	O
ATOM	85	C	SER		16	35.093	−2.690	−76.215	1.00	30.49	C
ATOM	86	O	SER		16	35.329	−3.711	−75.571	1.00	29.50	O
ATOM	87	N	ARG		17	34.047	−1.905	−75.973	1.00	37.72	N
ATOM	88	CA	ARG		17	33.089	−2.189	−74.902	1.00	40.43	C
ATOM	89	CB	ARG		17	32.196	−0.971	−74.656	1.00	48.73	C
ATOM	90	CG	ARG		17	32.922	0.209	−74.071	1.00	51.66	C
ATOM	91	CD	ARG		17	33.484	−0.140	−72.712	1.00	52.09	C
ATOM	92	NE	ARG		17	34.421	0.874	−72.246	1.00	54.91	N
ATOM	93	CZ	ARG		17	34.088	2.128	−71.959	1.00	55.39	C
ATOM	94	NH1	ARG		17	32.831	2.536	−72.084	1.00	55.18	N
ATOM	95	NH2	ARG		17	35.022	2.976	−71.558	1.00	55.61	N
ATOM	96	C	ARG		17	32.195	−3.391	−75.195	1.00	41.27	C
ATOM	97	O	ARG		17	31.874	−4.170	−74.298	1.00	40.34	O
ATOM	98	N	SER		18	31.793	−3.528	−76.452	1.00	38.74	N
ATOM	99	CA	SER		18	30.916	−4.614	−76.870	1.00	41.26	C
ATOM	100	CB	SER		18	30.303	−4.290	−78.236	1.00	41.67	C
ATOM	101	OG	SER		18	29.555	−3.092	−78.197	1.00	46.84	O
ATOM	102	C	SER		18	31.589	−5.977	−76.961	1.00	41.23	C
ATOM	103	O	SER		18	31.176	−6.934	−76.303	1.00	43.80	O
ATOM	104	N	SER		19	32.632	−6.051	−77.780	1.00	30.71	N
ATOM	105	CA	SER		19	33.344	−7.298	−78.023	1.00	30.26	C
ATOM	106	CB	SER		19	33.796	−7.347	−79.487	1.00	42.73	C
ATOM	107	OG	SER		19	34.735	−6.319	−79.762	1.00	44.23	O
ATOM	108	C	SER		19	34.544	−7.597	−77.140	1.00	29.87	C
ATOM	109	O	SER		19	34.920	−8.757	−76.993	1.00	29.63	O
ATOM	110	N	GLY		20	35.151	−6.566	−76.562	1.00	30.24	N
ATOM	111	CA	GLY		20	36.322	−6.794	−75.732	1.00	28.21	C
ATOM	112	C	GLY		20	37.576	−6.918	−76.588	1.00	27.03	C
ATOM	113	O	GLY		20	38.673	−7.140	−76.087	1.00	26.49	O
ATOM	114	N	ARG		21	37.415	−6.784	−77.898	1.00	31.19	N
ATOM	115	CA	ARG		21	38.549	−6.866	−78.807	1.00	30.60	C
ATOM	116	CB	ARG		21	38.063	−7.196	−80.219	1.00	45.79	C
ATOM	117	CG	ARG		21	38.946	−8.152	−81.013	1.00	50.43	C
ATOM	118	CD	ARG		21	38.498	−8.167	−82.465	1.00	52.82	C
ATOM	119	NE	ARG		21	37.045	−8.064	−82.552	1.00	52.89	N
ATOM	120	CZ	ARG		21	36.391	−7.481	−83.551	1.00	52.85	C
ATOM	121	NH1	ARG		21	37.055	−6.943	−84.569	1.00	51.07	N
ATOM	122	NH2	ARG		21	35.067	−7.411	−83.512	1.00	54.89	N
ATOM	123	C	ARG		21	39.216	−5.495	−78.812	1.00	27.77	C
ATOM	124	O	ARG		21	38.540	−4.466	−78.698	1.00	24.90	O
ATOM	125	N	VAL		22	40.535	−5.471	−78.937	1.00	27.42	N
ATOM	126	CA	VAL		22	41.248	−4.201	−78.971	1.00	26.89	C
ATOM	127	CB	VAL		22	42.777	−4.396	−78.768	1.00	36.69	C
ATOM	128	CG1	VAL		22	43.047	−5.169	−77.480	1.00	39.71	C
ATOM	129	CG2	VAL		22	43.373	−5.134	−79.959	1.00	38.47	C
ATOM	130	C	VAL		22	41.030	−3.537	−80.339	1.00	24.89	C
ATOM	131	O	VAL		22	40.745	−4.207	−81.332	1.00	23.24	O
ATOM	132	N	TYR		23	41.137	−2.217	−80.380	1.00	27.14	N
ATOM	133	CA	TYR		23	41.008	−1.487	−81.635	1.00	25.75	C
ATOM	134	CB	TYR		23	39.553	−1.092	−81.905	1.00	25.74	C
ATOM	135	CG	TYR		23	38.968	−0.035	−80.996	1.00	27.50	C
ATOM	136	CD1	TYR		23	38.850	1.287	−81.423	1.00	28.08	C
ATOM	137	CE1	TYR		23	38.263	2.249	−80.624	1.00	27.02	C
ATOM	138	CD2	TYR		23	38.486	−0.365	−79.735	1.00	28.62	C
ATOM	139	CE2	TYR		23	37.898	0.590	−78.921	1.00	30.69	C
ATOM	140	CZ	TYR		23	37.786	1.897	−79.372	1.00	29.96	C
ATOM	141	OH	TYR		23	37.187	2.845	−78.574	1.00	30.52	O
ATOM	142	C	TYR		23	41.898	−0.268	−81.504	1.00	26.35	C
ATOM	143	O	TYR		23	42.559	−0.101	−80.483	1.00	26.15	O
ATOM	144	N	TYR		24	41.943	0.571	−82.531	1.00	26.24	N
ATOM	145	CA	TYR		24	42.787	1.755	−82.476	1.00	26.60	C
ATOM	146	CB	TYR		24	43.939	1.628	−83.478	1.00	30.68	C
ATOM	147	CG	TYR		24	44.780	0.393	−83.249	1.00	35.00	C
ATOM	148	CD1	TYR		24	44.347	−0.858	−83.681	1.00	37.19	C
ATOM	149	CE1	TYR		24	45.082	−2.002	−83.411	1.00	38.80	C
ATOM	150	CD2	TYR		24	45.979	0.465	−82.544	1.00	37.77	C
ATOM	151	CE2	TYR		24	46.721	−0.671	−82.270	1.00	38.67	C
ATOM	152	CZ	TYR		24	46.268	−1.901	−82.704	1.00	40.68	C
ATOM	153	OH	TYR		24	46.997	−3.034	−82.422	1.00	42.21	O
ATOM	154	C	TYR		24	42.000	3.026	−82.732	1.00	25.90	C
ATOM	155	O	TYR		24	41.139	3.081	−83.611	1.00	23.89	O
ATOM	156	N	PHE		25	42.315	4.048	−81.950	1.00	27.07	N
ATOM	157	CA	PHE		25	41.653	5.337	−82.038	1.00	27.62	C
ATOM	158	CB	PHE		25	40.857	5.564	−80.753	1.00	31.38	C
ATOM	159	CG	PHE		25	40.293	6.939	−80.618	1.00	32.02	C
ATOM	160	CD1	PHE		25	39.220	7.350	−81.402	1.00	32.11	C
ATOM	161	CD2	PHE		25	40.827	7.829	−79.696	1.00	32.08	C
ATOM	162	CE1	PHE		25	38.686	8.624	−81.264	1.00	31.38	C
ATOM	163	CE2	PHE		25	40.299	9.103	−79.554	1.00	32.00	C
ATOM	164	CZ	PHE		25	39.225	9.500	−80.342	1.00	32.52	C
ATOM	165	C	PHE		25	42.694	6.446	−82.213	1.00	28.03	C
ATOM	166	O	PHE		25	43.786	6.379	−81.647	1.00	28.18	O
ATOM	167	N	ASN		26	42.349	7.456	−83.003	1.00	27.36	N
ATOM	168	CA	ASN		26	43.230	8.596	−83.246	1.00	27.09	C
ATOM	169	CB	ASN		26	43.482	8.767	−84.752	1.00	24.37	C
ATOM	170	CG	ASN		26	44.564	9.801	−85.053	1.00	22.43	C
ATOM	171	OD1	ASN		26	44.413	10.983	−84.743	1.00	22.07	O
ATOM	172	ND2	ASN		26	45.663	9.350	−85.660	1.00	22.99	N
ATOM	173	C	ASN		26	42.515	9.822	−82.676	1.00	24.70	C
ATOM	174	O	ASN		26	41.445	10.204	−83.154	1.00	24.38	O
ATOM	175	N	HIS		27	43.099	10.431	−81.648	1.00	20.16	N
ATOM	176	CA	HIS		27	42.475	11.583	−81.005	1.00	19.80	C
ATOM	177	CB	HIS		27	43.014	11.749	−79.577	1.00	21.98	C
ATOM	178	CG	HIS		27	44.467	12.091	−79.516	1.00	24.66	C
ATOM	179	CD2	HIS		27	45.547	11.334	−79.215	1.00	25.19	C
ATOM	180	ND1	HIS		27	44.946	13.352	−79.801	1.00	27.16	N
ATOM	181	CE1	HIS		27	46.261	13.357	−79.677	1.00	26.43	C
ATOM	182	NE2	HIS		27	46.651	12.145	−79.323	1.00	29.10	N
ATOM	183	C	HIS		27	42.606	12.899	−81.773	1.00	20.10	C
ATOM	184	O	HIS		27	42.059	13.920	−81.356	1.00	20.52	O
ATOM	185	N	ILE		28	43.321	12.872	−82.890	1.00	30.65	N
ATOM	186	CA	ILE		28	43.475	14.066	−83.706	1.00	31.11	C
ATOM	187	CB	ILE		28	44.887	14.145	−84.339	1.00	27.16	C
ATOM	188	CG2	ILE		28	45.013	15.413	−85.177	1.00	26.73	C
ATOM	189	CG1	ILE		28	45.951	14.155	−83.238	1.00	26.99	C
ATOM	190	CD1	ILE		28	47.379	14.051	−83.751	1.00	27.95	C
ATOM	191	C	ILE		28	42.417	14.040	−84.815	1.00	30.08	C
ATOM	192	O	ILE		28	41.760	15.042	−85.066	1.00	29.99	O
ATOM	193	N	THR		29	42.232	12.885	−85.452	1.00	24.76	N
ATOM	194	CA	THR		29	41.251	12.758	−86.533	1.00	24.81	C
ATOM	195	CB	THR		29	41.778	11.867	−87.653	1.00	22.03	C
ATOM	196	OG1	THR		29	41.859	10.520	−87.172	1.00	18.99	O
ATOM	197	CG2	THR		29	43.167	12.315	−88.100	1.00	21.61	C
ATOM	198	C	THR		29	39.916	12.153	−86.092	1.00	24.90	C
ATOM	199	O	THR		29	38.935	12.215	−86.834	1.00	23.10	O
ATOM	200	N	ASN		30	39.891	11.566	−84.895	1.00	27.70	N
ATOM	201	CA	ASN		30	38.701	10.907	−84.354	1.00	26.96	C
ATOM	202	CB	ASN		30	37.507	11.875	−84.317	1.00	20.48	C
ATOM	203	CG	ASN		30	37.499	12.735	−83.050	1.00	20.74	C
ATOM	204	OD1	ASN		30	36.882	13.801	−82.998	1.00	21.01	O
ATOM	205	ND2	ASN		30	38.180	12.260	−82.025	1.00	19.77	N
ATOM	206	C	ASN		30	38.352	9.632	−85.138	1.00	27.36	C
ATOM	207	O	ASN		30	37.208	9.161	−85.128	1.00	27.42	O
ATOM	208	N	ALA		31	39.345	9.074	−85.822	1.00	23.88	N
ATOM	209	CA	ALA		31	39.126	7.844	−86.567	1.00	24.36	C
ATOM	210	CB	ALA		31	40.114	7.725	−87.720	1.00	13.48	C
ATOM	211	C	ALA		31	39.302	6.658	−85.628	1.00	24.88	C
ATOM	212	O	ALA		31	40.042	6.731	−84.637	1.00	22.74	O
ATOM	213	N	SER		32	38.609	5.568	−85.931	1.00	20.13	N
ATOM	214	CA	SER		32	38.743	4.357	−85.134	1.00	21.45	C
ATOM	215	CB	SER		32	37.705	4.328	−84.009	1.00	14.79	C
ATOM	216	OG	SER		32	36.415	4.637	−84.488	1.00	20.62	O
ATOM	217	C	SER		32	38.608	3.156	−86.055	1.00	22.39	C
ATOM	218	O	SER		32	37.779	3.144	−86.963	1.00	21.77	O
ATOM	219	N	GLN		33	39.448	2.152	−85.837	1.00	25.22	N
ATOM	220	CA	GLN		33	39.432	0.965	−86.671	1.00	26.60	C
ATOM	221	CB	GLN		33	40.275	1.212	−87.925	1.00	21.68	C
ATOM	222	CG	GLN		33	41.732	1.547	−87.624	1.00	24.94	C
ATOM	223	CD	GLN		33	42.468	2.115	−88.826	1.00	29.02	C
ATOM	224	OE1	GLN		33	43.675	1.918	−88.985	1.00	33.19	O
ATOM	225	NE2	GLN		33	41.746	2.842	−89.670	1.00	25.93	N
ATOM	226	C	GLN		33	39.991	−0.221	−85.901	1.00	27.17	C
ATOM	227	O	GLN		33	40.700	−0.048	−84.907	1.00	25.99	O
ATOM	228	N	TRP		34	39.682	−1.424	−86.373	1.00	26.47	N
ATOM	229	CA	TRP		34	40.162	−2.640	−85.731	1.00	26.93	C
ATOM	230	CB	TRP		34	39.362	−3.854	−86.216	1.00	23.74	C
ATOM	231	CG	TRP		34	37.924	−3.811	−85.832	1.00	21.68	C
ATOM	232	CD2	TRP		34	37.391	−3.839	−84.507	1.00	22.32	C
ATOM	233	CE2	TRP		34	35.986	−3.796	−84.622	1.00	22.12	C
ATOM	234	CE3	TRP		34	37.964	−3.897	−83.234	1.00	22.16	C
ATOM	235	CD1	TRP		34	36.856	−3.750	−86.673	1.00	21.45	C
ATOM	236	NE1	TRP		34	35.687	−3.742	−85.957	1.00	20.94	N
ATOM	237	CZ2	TRP		34	35.144	−3.810	−83.513	1.00	23.32	C
ATOM	238	CZ3	TRP		34	37.130	−3.910	−82.134	1.00	23.35	C
ATOM	239	CH2	TRP		34	35.732	−3.867	−82.281	1.00	23.25	C
ATOM	240	C	TRP		34	41.628	−2.872	−86.024	1.00	28.82	C
ATOM	241	O	TRP		34	42.383	−3.307	−85.149	1.00	27.88	O
ATOM	242	N	GLU		35	42.027	−2.590	−87.259	1.00	22.19	N
ATOM	243	CA	GLU		35	43.413	−2.790	−87.683	1.00	25.69	C
ATOM	244	CB	GLU		35	43.511	−2.799	−89.210	1.00	113.10	C
ATOM	245	CG	GLU		35	43.358	−4.168	−89.844	1.00	114.00	C
ATOM	246	CD	GLU		35	44.025	−4.245	−91.206	1.00	114.83	C
ATOM	247	OE1	GLU		35	44.009	−5.331	−91.819	1.00	114.85	O
ATOM	248	OE2	GLU		35	44.573	−3.220	−91.663	1.00	113.87	O
ATOM	249	C	GLU		35	44.411	−1.776	−87.142	1.00	29.41	C
ATOM	250	O	GLU		35	44.112	−0.584	−87.014	1.00	28.07	O
ATOM	251	N	ARG		36	45.609	−2.260	−86.838	1.00	41.41	N
ATOM	252	CA	ARG		36	46.657	−1.394	−86.332	1.00	47.16	C
ATOM	253	CB	ARG		36	47.825	−2.221	−85.791	1.00	67.63	C
ATOM	254	CG	ARG		36	48.898	−1.381	−85.132	1.00	72.03	C
ATOM	255	CD	ARG		36	49.729	−2.193	−84.152	1.00	75.16	C
ATOM	256	NE	ARG		36	50.751	−1.372	−83.507	1.00	77.90	N
ATOM	257	CZ	ARG		36	51.475	−1.758	−82.462	1.00	79.60	C
ATOM	258	NH1	ARG		36	51.291	−2.960	−81.933	1.00	80.36	N
ATOM	259	NH2	ARG		36	52.385	−0.941	−81.946	1.00	80.00	N
ATOM	260	C	ARG		36	47.105	−0.521	−87.493	1.00	49.44	C
ATOM	261	O	ARG		36	47.498	−1.024	−88.547	1.00	49.61	O
ATOM	262	N	PRO		37	47.034	0.806	−87.315	1.00	38.51	N
ATOM	263	CD	PRO		37	46.684	1.454	−86.038	1.00	41.78	C
ATOM	264	CA	PRO		37	47.412	1.806	−88.317	1.00	41.36	C
ATOM	265	CB	PRO		37	47.091	3.125	−87.618	1.00	43.25	C
ATOM	266	CG	PRO		37	47.346	2.804	−86.175	1.00	42.40	C
ATOM	267	C	PRO		37	48.864	1.733	−88.778	1.00	44.20	C
ATOM	268	O	PRO		37	49.771	1.508	−87.976	1.00	44.35	O
ATOM	269	N	SER		38	49.066	1.932	−90.078	1.00	87.02	N
ATOM	270	CA	SER		38	50.397	1.909	−90.676	1.00	89.01	C
ATOM	271	CB	SER		38	51.164	3.173	−90.280	1.00	52.07	C
ATOM	272	OG	SER		38	50.428	4.332	−90.629	1.00	50.09	O
ATOM	273	C	SER		38	51.189	0.675	−90.259	1.00	90.20	C
ATOM	274	O	SER		38	52.230	0.370	−90.840	1.00	91.79	O
ATOM	275	N	GLU		51	54.661	14.646	−92.609	1.00	92.08	N
ATOM	276	CA	GLU		51	54.083	15.985	−92.549	1.00	91.73	C
ATOM	277	CB	GLU		51	54.678	16.760	−91.371	1.00	69.83	C
ATOM	278	CG	GLU		51	54.217	18.214	−91.243	1.00	68.90	C
ATOM	279	CD	GLU		51	52.766	18.356	−90.819	1.00	68.63	C
ATOM	280	OE1	GLU		51	52.358	17.695	−89.841	1.00	67.72	O
ATOM	281	OE2	GLU		51	52.037	19.144	−91.456	1.00	69.14	O
ATOM	282	C	GLU		51	54.343	16.739	−93.847	1.00	91.20	C
ATOM	283	O	GLU		51	55.210	17.611	−93.912	1.00	91.59	O
ATOM	284	N	PRO		52	53.594	16.400	−94.907	1.00	80.47	N
ATOM	285	CD	PRO		52	52.601	15.314	−94.967	1.00	63.31	C
ATOM	286	CA	PRO		52	53.741	17.048	−96.213	1.00	78.63	C
ATOM	287	CB	PRO		52	52.656	16.380	−97.052	1.00	62.58	C
ATOM	288	CG	PRO		52	52.557	15.009	−96.443	1.00	63.23	C
ATOM	289	C	PRO		52	53.532	18.553	−96.101	1.00	76.98	C
ATOM	290	O	PRO		52	52.906	19.031	−95.159	1.00	77.88	O
ATOM	291	N	ALA		53	54.062	19.295	−97.064	1.00	49.73	N
ATOM	292	CA	ALA		53	53.916	20.742	−97.069	1.00	47.22	C
ATOM	293	CB	ALA		53	54.698	21.340	−98.224	1.00	50.21	C
ATOM	294	C	ALA		53	52.439	21.069	−97.214	1.00	45.17	C
ATOM	295	O	ALA		53	51.914	21.969	−96.552	1.00	44.10	O
ATOM	296	N	ARG		54	51.769	20.322	−98.086	1.00	45.37	N
ATOM	297	CA	ARG		54	50.346	20.527	−98.329	1.00	42.09	C
ATOM	298	CB	ARG		54	50.145	21.379	−99.583	1.00	54.96	C
ATOM	299	CG	ARG		54	51.071	22.574	−99.703	1.00	59.03	C
ATOM	300	CD	ARG		54	50.896	23.234	−101.060	1.00	62.09	C
ATOM	301	NE	ARG		54	49.611	23.917	−101.168	1.00	63.23	N
ATOM	302	CZ	ARG		54	48.992	24.166	−102.318	1.00	65.00	C
ATOM	303	NH1	ARG		54	49.537	23.781	−103.464	1.00	65.68	N
ATOM	304	NH2	ARG		54	47.834	24.814	−102.324	1.00	65.50	N
ATOM	305	C	ARG		54	49.621	19.199	−98.527	1.00	38.23	C
ATOM	306	O	ARG		54	50.241	18.165	−98.784	1.00	37.73	O
ATOM	307	N	VAL		55	48.302	19.236	−98.396	1.00	32.71	N
ATOM	308	CA	VAL		55	47.482	18.052	−98.611	1.00	28.68	C
ATOM	309	CB	VAL		55	47.144	17.298	−97.293	1.00	27.56	C
ATOM	310	CG1	VAL		55	48.423	16.893	−96.572	1.00	25.19	C
ATOM	311	CG2	VAL		55	46.260	18.161	−96.401	1.00	24.60	C
ATOM	312	C	VAL		55	46.190	18.530	−99.243	1.00	27.59	C
ATOM	313	O	VAL		55	45.860	19.718	−99.188	1.00	26.57	O
ATOM	314	N	ARG		56	45.467	17.606	−99.860	1.00	28.91	N
ATOM	315	CA	ARG		56	44.200	17.937	−100.490	1.00	27.57	C
ATOM	316	CB	ARG		56	44.271	17.629	−101.985	1.00	25.81	C
ATOM	317	CG	ARG		56	43.002	17.945	−102.733	1.00	26.97	C
ATOM	318	CD	ARG		56	43.102	17.516	−104.196	1.00	28.35	C
ATOM	319	NE	ARG		56	41.908	17.897	−104.944	1.00	28.83	N
ATOM	320	CZ	ARG		56	41.713	17.638	−106.234	1.00	30.14	C
ATOM	321	NH1	ARG		56	42.639	16.993	−106.932	1.00	28.54	N
ATOM	322	NH2	ARG		56	40.590	18.029	−106.824	1.00	29.45	N
ATOM	323	C	ARG		56	43.106	17.100	−99.831	1.00	26.22	C
ATOM	324	O	ARG		56	43.262	15.892	−99.664	1.00	26.54	O
ATOM	325	N	CYS		57	42.002	17.739	−99.457	1.00	27.61	N
ATOM	326	CA	CYS		57	40.911	17.021	−98.815	1.00	27.07	C
ATOM	327	CB	CYS		57	40.937	17.251	−97.295	1.00	24.51	C
ATOM	328	SG	CYS		57	42.456	16.771	−96.448	1.00	23.28	S
ATOM	329	C	CYS		57	39.534	17.419	−99.313	1.00	27.66	C
ATOM	330	O	CYS		57	39.341	18.492	−99.901	1.00	27.75	O
ATOM	331	N	SER		58	38.575	16.528	−99.093	1.00	18.97	N
ATOM	332	CA	SER		58	37.188	16.815	−99.408	1.00	18.86	C
ATOM	333	CB	SER		58	36.589	15.788	−100.367	1.00	18.57	C
ATOM	334	OG	SER		58	37.161	15.901	−101.653	1.00	17.65	O
ATOM	335	C	SER		58	36.543	16.691	−98.033	1.00	19.26	C
ATOM	336	O	SER		58	37.154	16.148	−97.110	1.00	19.18	O
ATOM	337	N	HIS		59	35.340	17.213	−97.863	1.00	19.54	N
ATOM	338	CA	HIS		59	34.699	17.082	−96.572	1.00	19.45	C
ATOM	339	CB	HIS		59	35.213	18.150	−95.587	1.00	22.98	C
ATOM	340	CG	HIS		59	34.482	19.457	−95.650	1.00	25.80	C
ATOM	341	CD2	HIS		59	33.925	20.209	−94.671	1.00	24.13	C
ATOM	342	ND1	HIS		59	34.288	20.154	−96.824	1.00	25.49	N
ATOM	343	CE1	HIS		59	33.644	21.280	−96.566	1.00	23.15	C
ATOM	344	NE2	HIS		59	33.413	21.338	−95.266	1.00	27.95	N
ATOM	345	C	HIS		59	33.205	17.177	−96.728	1.00	19.68	C
ATOM	346	O	HIS		59	32.694	17.606	−97.772	1.00	18.30	O
ATOM	347	N	LEU		60	32.506	16.726	−95.701	1.00	27.73	N
ATOM	348	CA	LEU		60	31.060	16.777	−95.683	1.00	28.86	C
ATOM	349	CB	LEU		60	30.466	15.373	−95.663	1.00	17.06	C
ATOM	350	CG	LEU		60	28.944	15.258	−95.812	1.00	16.21	C
ATOM	351	CD1	LEU		60	28.592	13.791	−96.102	1.00	16.50	C
ATOM	352	CD2	LEU		60	28.239	15.749	−94.552	1.00	15.55	C
ATOM	353	C	LEU		60	30.781	17.494	−94.379	1.00	29.80	C
ATOM	354	O	LEU		60	31.179	17.037	−93.303	1.00	28.50	O
ATOM	355	N	LEU		61	30.108	18.631	−94.481	1.00	23.42	N
ATOM	356	CA	LEU		61	29.814	19.430	−93.309	1.00	24.50	C
ATOM	357	CB	LEU		61	30.235	20.883	−93.569	1.00	20.98	C
ATOM	358	CG	LEU		61	29.742	21.968	−92.603	1.00	21.15	C
ATOM	359	CD1	LEU		61	30.259	21.704	−91.188	1.00	23.45	C
ATOM	360	CD2	LEU		61	30.215	23.332	−93.110	1.00	23.24	C
ATOM	361	C	LEU		61	28.351	19.387	−92.917	1.00	24.25	C
ATOM	362	O	LEU		61	27.468	19.458	−93.767	1.00	22.30	O
ATOM	363	N	VAL		62	28.100	19.241	−91.622	1.00	23.07	N
ATOM	364	CA	VAL		62	26.733	19.260	−91.126	1.00	23.20	C
ATOM	365	CB	VAL		62	26.315	17.943	−90.474	1.00	22.43	C
ATOM	366	CG1	VAL		62	24.891	18.079	−89.908	1.00	22.75	C
ATOM	367	CG2	VAL		62	26.372	16.820	−91.504	1.00	23.21	C
ATOM	368	C	VAL		62	26.729	20.355	−90.080	1.00	24.20	C
ATOM	369	O	VAL		62	27.423	20.259	−89.052	1.00	21.83	O
ATOM	370	N	LYS		63	25.971	21.409	−90.358	1.00	31.76	N
ATOM	371	CA	LYS		63	25.886	22.547	−89.456	1.00	34.19	C
ATOM	372	CB	LYS		63	25.557	23.817	−90.233	1.00	37.41	C
ATOM	373	CG	LYS		63	26.669	24.304	−91.119	1.00	39.47	C
ATOM	374	CD	LYS		63	26.309	25.663	−91.666	1.00	40.11	C
ATOM	375	CE	LYS		63	27.374	26.178	−92.593	1.00	38.76	C
ATOM	376	NZ	LYS		63	27.057	27.566	−93.025	1.00	39.14	N
ATOM	377	C	LYS		63	24.826	22.355	−88.400	1.00	34.22	C
ATOM	378	O	LYS		63	24.014	21.436	−88.482	1.00	33.49	O
ATOM	379	N	HIS		64	24.843	23.245	−87.416	1.00	38.80	N
ATOM	380	CA	HIS		64	23.875	23.227	−86.336	1.00	39.34	C
ATOM	381	CB	HIS		64	24.374	22.350	−85.186	1.00	26.15	C
ATOM	382	CG	HIS		64	25.764	22.665	−84.739	1.00	27.92	C
ATOM	383	CD2	HIS		64	26.911	21.950	−84.822	1.00	28.71	C
ATOM	384	ND1	HIS		64	26.092	23.843	−84.104	1.00	27.69	N
ATOM	385	CE1	HIS		64	27.381	23.840	−83.815	1.00	30.59	C
ATOM	386	NE2	HIS		64	27.902	22.702	−84.240	1.00	29.36	N
ATOM	387	C	HIS		64	23.609	24.657	−85.866	1.00	39.50	C
ATOM	388	O	HIS		64	24.286	25.596	−86.298	1.00	38.46	O
ATOM	389	N	SER		65	22.620	24.811	−84.991	1.00	38.20	N
ATOM	390	CA	SER		65	22.227	26.120	−84.482	1.00	38.29	C
ATOM	391	CB	SER		65	21.107	25.965	−83.446	1.00	31.03	C
ATOM	392	OG	SER		65	21.538	25.220	−82.321	1.00	32.58	O
ATOM	393	C	SER		65	23.365	26.960	−83.901	1.00	39.21	C
ATOM	394	O	SER		65	23.274	28.183	−83.879	1.00	38.51	O
ATOM	395	N	GLN		66	24.432	26.321	−83.432	1.00	33.43	N
ATOM	396	CA	GLN		66	25.552	27.082	−82.881	1.00	34.22	C
ATOM	397	CB	GLN		66	26.079	26.434	−81.588	1.00	34.35	C
ATOM	398	CG	GLN		66	25.156	26.604	−80.370	1.00	34.76	C
ATOM	399	CD	GLN		66	25.801	26.146	−79.056	1.00	38.15	C
ATOM	400	OE1	GLN		66	26.820	26.693	−78.624	1.00	35.78	O
ATOM	401	NE2	GLN		66	25.209	25.136	−78.422	1.00	37.60	N
ATOM	402	C	GLN		66	26.707	27.293	−83.859	1.00	33.93	C
ATOM	403	O	GLN		66	27.775	27.762	−83.459	1.00	36.71	O
ATOM	404	N	SER		67	26.506	26.949	−85.132	1.00	24.38	N
ATOM	405	CA	SER		67	27.549	27.139	−86.146	1.00	25.76	C
ATOM	406	CB	SER		67	27.135	26.483	−87.477	1.00	34.89	C
ATOM	407	OG	SER		67	27.106	25.065	−87.383	1.00	31.75	O
ATOM	408	C	SER		67	27.776	28.641	−86.361	1.00	27.88	C
ATOM	409	O	SER		67	26.818	29.419	−86.334	1.00	27.78	O
ATOM	410	N	ARG		68	29.028	29.053	−86.582	1.00	35.49	N
ATOM	411	CA	ARG		68	29.313	30.480	−86.781	1.00	39.98	C
ATOM	412	CB	ARG		68	30.746	30.720	−87.289	1.00	92.68	C
ATOM	413	CG	ARG		68	31.456	29.514	−87.873	1.00	99.66	C
ATOM	414	CD	ARG		68	32.616	29.917	−88.797	1.00	104.74	C
ATOM	415	NE	ARG		68	33.740	30.557	−88.124	1.00	108.46	N
ATOM	416	CZ	ARG		68	34.781	31.080	−88.764	1.00	110.64	C
ATOM	417	NH1	ARG		68	34.832	31.043	−90.088	1.00	110.85	N
ATOM	418	NH2	ARG		68	35.780	31.623	−88.081	1.00	112.10	N
ATOM	419	C	ARG		68	28.313	31.130	−87.736	1.00	39.81	C
ATOM	420	O	ARG		68	28.006	32.312	−87.607	1.00	39.99	O
ATOM	421	N	ARG		69	27.797	30.351	−88.681	1.00	46.18	N
ATOM	422	CA	ARG		69	26.813	30.850	−89.635	1.00	44.85	C
ATOM	423	CB	ARG		69	27.493	31.223	−90.950	1.00	59.80	C
ATOM	424	CG	ARG		69	28.495	32.359	−90.826	1.00	63.97	C
ATOM	425	CD	ARG		69	29.354	32.430	−92.064	1.00	68.66	C
ATOM	426	NE	ARG		69	28.542	32.337	−93.272	1.00	72.47	N
ATOM	427	CZ	ARG		69	29.037	32.173	−94.494	1.00	75.20	C
ATOM	428	NH1	ARG		69	30.349	32.083	−94.672	1.00	76.93	N
ATOM	429	NH2	ARG		69	28.222	32.096	−95.538	1.00	76.34	N
ATOM	430	C	ARG		69	25.768	29.765	−89.877	1.00	43.28	C
ATOM	431	O	ARG		69	25.914	28.934	−90.772	1.00	41.76	O
ATOM	432	N	PRO		70	24.691	29.771	−89.078	1.00	30.50	N
ATOM	433	CD	PRO		70	24.448	30.802	−88.052	1.00	37.86	C
ATOM	434	CA	PRO		70	23.577	28.816	−89.134	1.00	29.58	C
ATOM	435	CB	PRO		70	22.765	29.170	−87.889	1.00	36.97	C
ATOM	436	CG	PRO		70	22.968	30.647	−87.775	1.00	37.19	C
ATOM	437	C	PRO		70	22.739	28.847	−90.408	1.00	28.58	C
ATOM	438	O	PRO		70	21.505	28.850	−90.350	1.00	27.99	O
ATOM	439	N	SER		71	23.413	28.846	−91.555	1.00	31.28	N
ATOM	440	CA	SER		71	22.732	28.875	−92.847	1.00	28.94	C
ATOM	441	CB	SER		71	22.449	30.324	−93.252	1.00	58.35	C
ATOM	442	OG	SER		71	21.771	30.391	−94.494	1.00	63.72	O
ATOM	443	C	SER		71	23.589	28.206	−93.922	1.00	26.93	C
ATOM	444	O	SER		71	24.817	28.186	−93.815	1.00	25.77	O
ATOM	445	N	SER		72	22.945	27.657	−94.950	1.00	27.32	N
ATOM	446	CA	SER		72	23.669	27.004	−96.043	1.00	27.77	C
ATOM	447	CB	SER		72	24.090	25.588	−95.639	1.00	32.27	C
ATOM	448	OG	SER		72	22.970	24.718	−95.683	1.00	28.53	O
ATOM	449	C	SER		72	22.784	26.908	−97.277	1.00	27.26	C
ATOM	450	O	SER		72	21.598	27.208	−97.211	1.00	27.46	O
ATOM	451	N	TRP		73	23.357	26.466	−98.393	1.00	28.76	N
ATOM	452	CA	TRP		73	22.596	26.318	−99.631	1.00	27.44	C
ATOM	453	CB	TRP		73	23.510	25.873	−100.783	1.00	26.47	C
ATOM	454	CG	TRP		73	24.047	24.460	−100.637	1.00	27.29	C
ATOM	455	CD2	TRP		73	23.430	23.252	−101.108	1.00	26.36	C
ATOM	456	CE2	TRP		73	24.267	22.180	−100.730	1.00	25.53	C
ATOM	457	CE3	TRP		73	22.252	22.973	−101.810	1.00	26.63	C
ATOM	458	CD1	TRP		73	25.199	24.079	−100.010	1.00	26.10	C
ATOM	459	NE1	TRP		73	25.339	22.712	−100.062	1.00	25.00	N
ATOM	460	CZ2	TRP		73	23.964	20.853	−101.031	1.00	25.25	C
ATOM	461	CZ3	TRP		73	21.951	21.649	−102.106	1.00	26.55	C
ATOM	462	CH2	TRP		73	22.805	20.607	−101.715	1.00	25.37	C
ATOM	463	C	TRP		73	21.461	25.304	−99.472	1.00	27.18	C
ATOM	464	O	TRP		73	20.519	25.297	−100.261	1.00	27.30	O
ATOM	465	N	ARG		74	21.547	24.448	−98.456	1.00	30.87	N
ATOM	466	CA	ARG		74	20.508	23.442	−98.232	1.00	30.38	C
ATOM	467	CB	ARG		74	21.074	22.246	−97.457	1.00	28.25	C
ATOM	468	CG	ARG		74	22.278	21.581	−98.127	1.00	27.61	C
ATOM	469	CD	ARG		74	22.506	20.191	−97.548	1.00	27.22	C
ATOM	470	NE	ARG		74	21.346	19.345	−97.807	1.00	27.38	N
ATOM	471	CZ	ARG		74	20.740	18.605	−96.887	1.00	28.74	C
ATOM	472	NH1	ARG		74	21.185	18.603	−95.636	1.00	32.43	N
ATOM	473	NH2	ARG		74	19.685	17.874	−97.221	1.00	30.48	N
ATOM	474	C	ARG		74	19.286	23.998	−97.492	1.00	31.33	C
ATOM	475	O	ARG		74	18.160	23.578	−97.742	1.00	30.12	O
ATOM	476	N	GLN		75	19.507	24.925	−96.569	1.00	32.46	N
ATOM	477	CA	GLN		75	18.399	25.530	−95.838	1.00	34.90	C
ATOM	478	CB	GLN		75	17.905	24.611	−94.718	1.00	46.12	C
ATOM	479	CG	GLN		75	18.962	24.174	−93.739	1.00	49.44	C
ATOM	480	CD	GLN		75	18.394	23.318	−92.618	1.00	51.76	C
ATOM	481	OE1	GLN		75	19.128	22.836	−91.755	1.00	51.77	O
ATOM	482	NE2	GLN		75	17.079	23.126	−92.627	1.00	51.35	N
ATOM	483	C	GLN		75	18.827	26.880	−95.281	1.00	33.48	C
ATOM	484	O	GLN		75	19.858	26.997	−94.606	1.00	32.57	O
ATOM	485	N	GLU		76	18.021	27.895	−95.583	1.00	31.46	N
ATOM	486	CA	GLU		76	18.295	29.266	−95.182	1.00	29.82	C
ATOM	487	CB	GLU		76	17.127	30.171	−95.598	1.00	34.27	C
ATOM	488	CG	GLU		76	17.477	31.654	−95.589	1.00	33.68	C
ATOM	489	CD	GLU		76	16.467	32.511	−96.342	1.00	33.92	C
ATOM	490	OE1	GLU		76	16.710	33.730	−96.470	1.00	33.77	O
ATOM	491	OE2	GLU		76	15.438	31.972	−96.803	1.00	30.89	O
ATOM	492	C	GLU		76	18.586	29.425	−93.694	1.00	30.64	C
ATOM	493	O	GLU		76	19.451	30.212	−93.305	1.00	29.95	O
ATOM	494	N	LYS		77	17.873	28.671	−92.867	1.00	40.14	N
ATOM	495	CA	LYS		77	18.067	28.742	−91.425	1.00	42.89	C
ATOM	496	CB	LYS		77	16.858	29.415	−90.770	1.00	54.20	C
ATOM	497	CG	LYS		77	16.979	29.589	−89.266	1.00	58.94	C
ATOM	498	CD	LYS		77	18.161	30.485	−88.906	1.00	61.26	C
ATOM	499	CE	LYS		77	18.216	30.758	−87.407	1.00	61.74	C
ATOM	500	NZ	LYS		77	16.943	31.351	−86.903	1.00	63.16	N
ATOM	501	C	LYS		77	18.271	27.354	−90.823	1.00	42.48	C
ATOM	502	O	LYS		77	17.316	26.591	−90.665	1.00	42.05	O
ATOM	503	N	ILE		78	19.517	27.031	−90.492	1.00	32.29	N
ATOM	504	CA	ILE		78	19.843	25.738	−89.893	1.00	32.05	C
ATOM	505	CB	ILE		78	21.361	25.478	−89.919	1.00	43.39	C
ATOM	506	CG2	ILE		78	21.648	24.075	−89.406	1.00	42.19	C
ATOM	507	CG1	ILE		78	21.906	25.640	−91.340	1.00	44.66	C
ATOM	508	CD1	ILE		78	21.671	24.445	−92.229	1.00	44.62	C
ATOM	509	C	ILE		78	19.404	25.787	−88.429	1.00	31.81	C
ATOM	510	O	ILE		78	19.882	26.629	−87.671	1.00	32.03	O
ATOM	511	N	THR		79	18.522	24.879	−88.026	1.00	41.78	N
ATOM	512	CA	THR		79	18.026	24.868	−86.655	1.00	41.88	C
ATOM	513	CB	THR		79	16.499	25.017	−86.650	1.00	37.05	C
ATOM	514	OG1	THR		79	15.911	23.916	−87.353	1.00	38.12	O
ATOM	515	CG2	THR		79	16.093	26.317	−87.330	1.00	38.02	C
ATOM	516	C	THR		79	18.391	23.635	−85.817	1.00	41.44	C
ATOM	517	O	THR		79	18.244	23.643	−84.594	1.00	40.19	O
ATOM	518	N	ARG		80	18.863	22.578	−86.468	1.00	30.81	N
ATOM	519	CA	ARG		80	19.226	21.356	−85.758	1.00	28.34	C
ATOM	520	CB	ARG		80	19.839	20.346	−86.734	1.00	30.37	C
ATOM	521	CG	ARG		80	21.189	20.798	−87.278	1.00	31.24	C
ATOM	522	CD	ARG		80	21.912	19.709	−88.049	1.00	31.66	C
ATOM	523	NE	ARG		80	21.703	19.835	−89.488	1.00	35.73	N
ATOM	524	CZ	ARG		80	20.633	19.374	−90.117	1.00	36.07	C
ATOM	525	NH1	ARG		80	19.689	18.757	−89.417	1.00	37.81	N
ATOM	526	NH2	ARG		80	20.510	19.525	−91.435	1.00	34.27	N
ATOM	527	C	ARG		80	20.224	21.633	−84.629	1.00	26.44	C
ATOM	528	O	ARG		80	21.080	22.520	−84.739	1.00	26.14	O
ATOM	529	N	THR		81	20.114	20.866	−83.547	1.00	27.39	N
ATOM	530	CA	THR		81	21.019	21.015	−82.414	1.00	29.21	C
ATOM	531	CB	THR		81	20.466	20.314	−81.151	1.00	27.15	C
ATOM	532	OG1	THR		81	20.562	18.892	−81.304	1.00	28.13	O
ATOM	533	CG2	THR		81	19.002	20.684	−80.933	1.00	28.09	C
ATOM	534	C	THR		81	22.353	20.362	−82.772	1.00	29.67	C
ATOM	535	O	THR		81	22.442	19.624	−83.748	1.00	29.35	O
ATOM	536	N	LYS		82	23.386	20.629	−81.983	1.00	28.05	N
ATOM	537	CA	LYS		82	24.688	20.025	−82.229	1.00	27.86	C
ATOM	538	CB	LYS		82	25.716	20.526	−81.219	1.00	41.11	C
ATOM	539	CG	LYS		82	25.852	22.029	−81.170	1.00	46.40	C
ATOM	540	CD	LYS		82	27.119	22.425	−80.443	1.00	48.62	C
ATOM	541	CE	LYS		82	27.205	21.764	−79.083	1.00	51.16	C
ATOM	542	NZ	LYS		82	28.509	22.068	−78.445	1.00	51.86	N
ATOM	543	C	LYS		82	24.578	18.505	−82.110	1.00	27.47	C
ATOM	544	O	LYS		82	25.238	17.761	−82.837	1.00	23.66	O
ATOM	545	N	GLU		83	23.750	18.050	−81.175	1.00	25.01	N
ATOM	546	CA	GLU		83	23.573	16.623	−80.962	1.00	25.48	C
ATOM	547	CB	GLU		83	22.700	16.373	−79.727	1.00	34.29	C
ATOM	548	CG	GLU		83	23.368	16.790	−78.413	1.00	39.06	C
ATOM	549	CD	GLU		83	23.555	18.306	−78.270	1.00	41.07	C
ATOM	550	OE1	GLU		83	24.368	18.723	−77.417	1.00	44.38	O
ATOM	551	OE2	GLU		83	22.889	19.082	−78.992	1.00	40.83	O
ATOM	552	C	GLU		83	22.957	15.963	−82.189	1.00	23.05	C
ATOM	553	O	GLU		83	23.410	14.907	−82.625	1.00	21.19	O
ATOM	554	N	GLU		84	21.925	16.583	−82.749	1.00	32.44	N
ATOM	555	CA	GLU		84	21.278	16.026	−83.931	1.00	32.29	C
ATOM	556	CB	GLU		84	20.041	16.847	−84.297	1.00	29.92	C
ATOM	557	CG	GLU		84	19.008	16.944	−83.179	1.00	33.27	C
ATOM	558	CD	GLU		84	17.803	17.784	−83.573	1.00	34.77	C
ATOM	559	OE1	GLU		84	18.000	18.929	−84.034	1.00	33.01	O
ATOM	560	OE2	GLU		84	16.662	17.303	−83.421	1.00	37.17	O
ATOM	561	C	GLU		84	22.262	16.009	−85.108	1.00	32.11	C
ATOM	562	O	GLU		84	22.257	15.084	−85.927	1.00	31.49	O
ATOM	563	N	ALA		85	23.109	17.033	−85.175	1.00	23.50	N
ATOM	564	CA	ALA		85	24.098	17.144	−86.235	1.00	23.22	C
ATOM	565	CB	ALA		85	24.796	18.512	−86.166	1.00	20.42	C
ATOM	566	C	ALA		85	25.130	16.026	−86.123	1.00	23.16	C
ATOM	567	O	ALA		85	25.553	15.450	−87.131	1.00	21.09	O
ATOM	568	N	LEU		86	25.539	15.730	−84.893	1.00	23.72	N
ATOM	569	CA	LEU		86	26.513	14.678	−84.666	1.00	23.10	C
ATOM	570	CB	LEU		86	26.934	14.647	−83.190	1.00	21.81	C
ATOM	571	CG	LEU		86	27.918	13.548	−82.752	1.00	23.22	C
ATOM	572	CD1	LEU		86	29.108	13.493	−83.704	1.00	22.43	C
ATOM	573	CD2	LEU		86	28.385	13.822	−81.306	1.00	22.52	C
ATOM	574	C	LEU		86	25.904	13.342	−85.084	1.00	23.86	C
ATOM	575	O	LEU		86	26.590	12.496	−85.646	1.00	21.37	O
ATOM	576	N	GLU		87	24.609	13.162	−84.830	1.00	25.62	N
ATOM	577	CA	GLU		87	23.941	11.917	−85.204	1.00	28.23	C
ATOM	578	CB	GLU		87	22.531	11.863	−84.615	1.00	52.02	C
ATOM	579	CG	GLU		87	22.509	11.251	−83.233	1.00	57.63	C
ATOM	580	CD	GLU		87	23.234	9.915	−83.201	1.00	63.43	C
ATOM	581	OE1	GLU		87	22.812	8.992	−83.932	1.00	63.83	O
ATOM	582	OE2	GLU		87	24.231	9.789	−82.456	1.00	66.82	O
ATOM	583	C	GLU		87	23.880	11.710	−86.712	1.00	27.09	C
ATOM	584	O	GLU		87	23.992	10.579	−87.200	1.00	24.91	O
ATOM	585	N	LEU		88	23.688	12.801	−87.448	1.00	24.58	N
ATOM	586	CA	LEU		88	23.632	12.744	−88.900	1.00	23.33	C
ATOM	587	CB	LEU		88	23.219	14.114	−89.457	1.00	22.15	C
ATOM	588	CG	LEU		88	21.721	14.435	−89.292	1.00	25.36	C
ATOM	589	CD1	LEU		88	21.428	15.941	−89.461	1.00	23.78	C
ATOM	590	CD2	LEU		88	20.950	13.611	−90.315	1.00	23.79	C
ATOM	591	C	LEU		88	25.013	12.346	−89.404	1.00	21.25	C
ATOM	592	O	LEU		88	25.149	11.495	−90.290	1.00	21.56	O
ATOM	593	N	ILE		89	26.035	12.964	−88.820	1.00	20.76	N
ATOM	594	CA	ILE		89	27.416	12.682	−89.171	1.00	20.56	C
ATOM	595	CB	ILE		89	28.375	13.559	−88.337	1.00	16.51	C
ATOM	596	CG2	ILE		89	29.778	12.958	−88.336	1.00	16.76	C
ATOM	597	CG1	ILE		89	28.405	14.988	−88.903	1.00	15.05	C
ATOM	598	CD1	ILE		89	29.296	15.144	−90.156	1.00	14.12	C
ATOM	599	C	ILE		89	27.709	11.204	−88.922	1.00	22.38	C
ATOM	600	O	ILE		89	28.293	10.532	−89.773	1.00	20.93	O
ATOM	601	N	ASN		90	27.289	10.696	−87.764	1.00	20.29	N
ATOM	602	CA	ASN		90	27.514	9.294	−87.433	1.00	21.57	C
ATOM	603	CB	ASN		90	27.026	8.976	−86.017	1.00	23.78	C
ATOM	604	CG	ASN		90	27.918	9.587	−84.945	1.00	24.81	C
ATOM	605	OD1	ASN		90	29.118	9.774	−85.153	1.00	28.53	O
ATOM	606	ND2	ASN		90	27.339	9.882	−83.791	1.00	28.96	N
ATOM	607	C	ASN		90	26.840	8.369	−88.436	1.00	21.58	C
ATOM	608	O	ASN		90	27.416	7.356	−88.829	1.00	21.84	O
ATOM	609	N	GLY		91	25.629	8.723	−88.859	1.00	21.28	N
ATOM	610	CA	GLY		91	24.925	7.904	−89.835	1.00	21.25	C
ATOM	611	C	GLY		91	25.655	7.865	−91.175	1.00	22.34	C
ATOM	612	O	GLY		91	25.777	6.817	−91.808	1.00	21.66	O
ATOM	613	N	TYR		92	26.156	9.016	−91.606	1.00	18.22	N
ATOM	614	CA	TYR		92	26.871	9.115	−92.878	1.00	17.74	C
ATOM	615	CB	TYR		92	27.219	10.582	−93.171	1.00	21.82	C
ATOM	616	CG	TYR		92	26.007	11.461	−93.408	1.00	22.95	C
ATOM	617	CD1	TYR		92	26.006	12.804	−93.032	1.00	23.15	C
ATOM	618	CE1	TYR		92	24.900	13.614	−93.263	1.00	23.87	C
ATOM	619	CD2	TYR		92	24.867	10.951	−94.022	1.00	22.47	C
ATOM	620	CE2	TYR		92	23.756	11.749	−94.256	1.00	24.76	C
ATOM	621	CZ	TYR		92	23.782	13.081	−93.875	1.00	23.95	C
ATOM	622	OH	TYR		92	22.687	13.875	−94.128	1.00	23.63	O
ATOM	623	C	TYR		92	28.140	8.276	−92.840	1.00	14.83	C
ATOM	624	O	TYR		92	28.456	7.576	−93.802	1.00	16.50	O
ATOM	625	N	ILE		93	28.867	8.359	−91.728	1.00	14.02	N
ATOM	626	CA	ILE		93	30.094	7.595	−91.574	1.00	17.07	C
ATOM	627	CB	ILE		93	30.787	7.931	−90.224	1.00	18.29	C
ATOM	628	CG2	ILE		93	31.878	6.913	−89.907	1.00	18.42	C
ATOM	629	CG1	ILE		93	31.386	9.345	−90.295	1.00	18.84	C
ATOM	630	CD1	ILE		93	32.022	9.803	−88.996	1.00	18.79	C
ATOM	631	C	ILE		93	29.752	6.101	−91.654	1.00	16.85	C
ATOM	632	O	ILE		93	30.430	5.333	−92.345	1.00	15.46	O
ATOM	633	N	GLN		94	28.680	5.696	−90.981	1.00	18.85	N
ATOM	634	CA	GLN		94	28.284	4.290	−91.017	1.00	22.05	C
ATOM	635	CB	GLN		94	27.023	4.043	−90.194	1.00	31.01	C
ATOM	636	CG	GLN		94	27.235	4.075	−88.698	1.00	33.71	C
ATOM	637	CD	GLN		94	26.065	3.462	−87.954	1.00	38.87	C
ATOM	638	OE1	GLN		94	24.923	3.910	−88.090	1.00	39.90	O
ATOM	639	NE2	GLN		94	26.342	2.424	−87.167	1.00	39.16	N
ATOM	640	C	GLN		94	28.040	3.815	−92.441	1.00	21.88	C
ATOM	641	O	GLN		94	28.522	2.746	−92.835	1.00	22.96	O
ATOM	642	N	LYS		95	27.302	4.608	−93.213	1.00	20.75	N
ATOM	643	CA	LYS		95	27.000	4.237	−94.589	1.00	20.25	C
ATOM	644	CB	LYS		95	25.913	5.147	−95.161	1.00	36.57	C
ATOM	645	CG	LYS		95	24.515	4.846	−94.627	1.00	41.80	C
ATOM	646	CD	LYS		95	23.452	5.506	−95.493	1.00	45.97	C
ATOM	647	CE	LYS		95	22.041	5.102	−95.078	1.00	48.42	C
ATOM	648	NZ	LYS		95	21.657	5.647	−93.747	1.00	52.23	N
ATOM	649	C	LYS		95	28.221	4.252	−95.492	1.00	19.28	C
ATOM	650	O	LYS		95	28.330	3.448	−96.419	1.00	19.18	O
ATOM	651	N	ILE		96	29.138	5.175	−95.236	1.00	19.74	N
ATOM	652	CA	ILE		96	30.353	5.254	−96.032	1.00	19.01	C
ATOM	653	CB	ILE		96	31.161	6.525	−95.676	1.00	20.13	C
ATOM	654	CG2	ILE		96	32.566	6.431	−96.240	1.00	18.08	C
ATOM	655	CG1	ILE		96	30.416	7.766	−96.187	1.00	20.05	C
ATOM	656	CD1	ILE		96	31.124	9.089	−95.876	1.00	20.90	C
ATOM	657	C	ILE		96	31.212	4.019	−95.749	1.00	17.74	C
ATOM	658	O	ILE		96	31.706	3.353	−96.669	1.00	19.21	O
ATOM	659	N	LYS		97	31.369	3.711	−94.468	1.00	18.05	N
ATOM	660	CA	LYS		97	32.176	2.570	−94.070	1.00	18.43	C
ATOM	661	CB	LYS		97	32.412	2.573	−92.559	1.00	23.17	C
ATOM	662	CG	LYS		97	33.542	3.466	−92.106	1.00	24.88	C
ATOM	663	CD	LYS		97	33.819	3.238	−90.631	1.00	23.47	C
ATOM	664	CE	LYS		97	35.077	3.964	−90.190	1.00	25.08	C
ATOM	665	NZ	LYS		97	35.420	3.637	−88.779	1.00	25.12	N
ATOM	666	C	LYS		97	31.581	1.229	−94.483	1.00	18.99	C
ATOM	667	O	LYS		97	32.321	0.279	−94.714	1.00	18.62	O
ATOM	668	N	SER		98	30.255	1.154	−94.565	1.00	17.76	N
ATOM	669	CA	SER		98	29.586	−0.085	−94.969	1.00	20.00	C
ATOM	670	CB	SER		98	28.123	−0.078	−94.523	1.00	19.57	C
ATOM	671	OG	SER		98	27.376	0.876	−95.268	1.00	19.19	O
ATOM	672	C	SER		98	29.625	−0.250	−96.488	1.00	21.18	C
ATOM	673	O	SER		98	29.393	−1.340	−97.013	1.00	20.44	O
ATOM	674	N	GLY		99	29.914	0.834	−97.199	1.00	17.02	N
ATOM	675	CA	GLY		99	29.943	0.748	−98.645	1.00	18.61	C
ATOM	676	C	GLY		99	28.561	0.990	−99.232	1.00	19.63	C
ATOM	677	O	GLY		99	28.396	1.031	−100.450	1.00	20.28	O
ATOM	678	N	GLU		100	27.560	1.136	−98.369	1.00	23.74	N
ATOM	679	CA	GLU		100	26.204	1.408	−98.832	1.00	26.69	C
ATOM	680	CB	GLU		100	25.252	1.579	−97.647	1.00	37.56	C
ATOM	681	CG	GLU		100	24.914	0.302	−96.905	1.00	45.64	C
ATOM	682	CD	GLU		100	24.090	0.564	−95.656	1.00	47.74	C
ATOM	683	OE1	GLU		100	24.656	1.051	−94.652	1.00	49.67	O
ATOM	684	OE2	GLU		100	22.872	0.291	−95.685	1.00	52.07	O
ATOM	685	C	GLU		100	26.191	2.701	−99.656	1.00	27.50	C
ATOM	686	O	GLU		100	25.443	2.823	−100.622	1.00	28.63	O
ATOM	687	N	GLU		101	27.026	3.661	−99.266	1.00	30.63	N
ATOM	688	CA	GLU		101	27.092	4.952	−99.950	1.00	33.03	C
ATOM	689	CB	GLU		101	26.185	5.965	−99.239	1.00	40.02	C
ATOM	690	CG	GLU		101	24.700	5.743	−99.442	1.00	43.12	C
ATOM	691	CD	GLU		101	24.206	6.365	−100.726	1.00	44.86	C
ATOM	692	OE1	GLU		101	24.738	6.019	−101.800	1.00	48.15	O
ATOM	693	OE2	GLU		101	23.289	7.210	−100.663	1.00	47.74	O
ATOM	694	C	GLU		101	28.516	5.488	−99.951	1.00	32.43	C
ATOM	695	O	GLU		101	29.223	5.391	−98.947	1.00	34.71	O
ATOM	696	N	ASP		102	28.953	6.054	−101.068	1.00	22.76	N
ATOM	697	CA	ASP		102	30.303	6.595	−101.088	1.00	23.62	C
ATOM	698	CB	ASP		102	30.933	6.463	−102.479	1.00	73.61	C
ATOM	699	CG	ASP		102	30.014	6.907	−103.582	1.00	76.83	C
ATOM	700	OD1	ASP		102	30.385	6.733	−104.763	1.00	82.29	O
ATOM	701	OD2	ASP		102	28.924	7.428	−103.272	1.00	80.71	O
ATOM	702	C	ASP		102	30.309	8.047	−100.610	1.00	21.48	C
ATOM	703	O	ASP		102	29.311	8.771	−100.725	1.00	19.79	O
ATOM	704	N	PHE		103	31.439	8.444	−100.048	1.00	24.32	N
ATOM	705	CA	PHE		103	31.640	9.785	−99.516	1.00	23.29	C
ATOM	706	CB	PHE		103	33.129	9.982	−99.212	1.00	25.00	C
ATOM	707	CG	PHE		103	33.470	11.348	−98.691	1.00	26.07	C
ATOM	708	CD1	PHE		103	33.355	11.637	−97.341	1.00	26.61	C
ATOM	709	CD2	PHE		103	33.879	12.351	−99.561	1.00	27.96	C
ATOM	710	CE1	PHE		103	33.639	12.903	−96.861	1.00	27.03	C
ATOM	711	CE2	PHE		103	34.166	13.625	−99.090	1.00	27.71	C
ATOM	712	CZ	PHE		103	34.045	13.899	−97.736	1.00	26.49	C
ATOM	713	C	PHE		103	31.155	10.904	−100.447	1.00	21.97	C
ATOM	714	O	PHE		103	30.372	11.765	−100.044	1.00	20.10	O
ATOM	715	N	GLU		104	31.615	10.880	−101.696	1.00	25.36	N
ATOM	716	CA	GLU		104	31.262	11.917	−102.664	1.00	27.12	C
ATOM	717	CB	GLU		104	31.940	11.635	−104.013	1.00	26.47	C
ATOM	718	CG	GLU		104	33.460	11.565	−103.932	1.00	27.20	C
ATOM	719	CD	GLU		104	33.979	10.187	−103.534	1.00	28.18	C
ATOM	720	OE1	GLU		104	33.249	9.411	−102.873	1.00	28.08	O
ATOM	721	OE2	GLU		104	35.138	9.890	−103.877	1.00	31.69	O
ATOM	722	C	GLU		104	29.767	12.107	−102.874	1.00	26.72	C
ATOM	723	O	GLU		104	29.291	13.234	−103.054	1.00	27.16	O
ATOM	724	N	SER		105	29.032	11.003	−102.866	1.00	22.30	N
ATOM	725	CA	SER		105	27.592	11.042	−103.066	1.00	24.72	C
ATOM	726	CB	SER		105	27.053	9.624	−103.223	1.00	30.44	C
ATOM	727	OG	SER		105	25.644	9.625	−103.319	1.00	32.49	O
ATOM	728	C	SER		105	26.884	11.737	−101.905	1.00	23.59	C
ATOM	729	O	SER		105	26.000	12.573	−102.107	1.00	23.88	O
ATOM	730	N	LEU		106	27.266	11.383	−100.686	1.00	18.90	N
ATOM	731	CA	LEU		106	26.663	11.989	−99.501	1.00	17.51	C
ATOM	732	CB	LEU		106	27.067	11.206	−98.249	1.00	16.55	C
ATOM	733	CG	LEU		106	26.564	9.757	−98.188	1.00	17.23	C
ATOM	734	CD1	LEU		106	27.020	9.107	−96.890	1.00	15.14	C
ATOM	735	CD2	LEU		106	25.037	9.746	−98.288	1.00	16.78	C
ATOM	736	C	LEU		106	27.083	13.459	−99.362	1.00	17.57	C
ATOM	737	O	LEU		106	26.309	14.286	−98.902	1.00	18.18	O
ATOM	738	N	ALA		107	28.307	13.788	−99.756	1.00	22.43	N
ATOM	739	CA	ALA		107	28.756	15.170	−99.656	1.00	23.57	C
ATOM	740	CB	ALA		107	30.255	15.267	−99.966	1.00	17.75	C
ATOM	741	C	ALA		107	27.957	16.056	−100.618	1.00	24.31	C
ATOM	742	O	ALA		107	27.499	17.141	−100.246	1.00	23.20	O
ATOM	743	N	SER		108	27.790	15.582	−101.851	1.00	22.34	N
ATOM	744	CA	SER		108	27.061	16.328	−102.869	1.00	23.59	C
ATOM	745	CB	SER		108	27.078	15.572	−104.202	1.00	26.85	C
ATOM	746	OG	SER		108	28.398	15.411	−104.689	1.00	31.79	O
ATOM	747	C	SER		108	25.615	16.541	−102.447	1.00	24.10	C
ATOM	748	O	SER		108	25.031	17.596	−102.684	1.00	24.01	O
ATOM	749	N	GLN		109	25.046	15.527	−101.812	1.00	23.12	N
ATOM	750	CA	GLN		109	23.663	15.579	−101.371	1.00	25.11	C
ATOM	751	CB	GLN		109	23.096	14.167	−101.267	1.00	30.14	C
ATOM	752	CG	GLN		109	22.803	13.476	−102.572	1.00	30.70	C
ATOM	753	CD	GLN		109	22.390	12.039	−102.337	1.00	33.54	C
ATOM	754	OE1	GLN		109	23.236	11.156	−102.166	1.00	34.39	O
ATOM	755	NE2	GLN		109	21.089	11.800	−102.298	1.00	32.03	N
ATOM	756	C	GLN		109	23.384	16.258	−100.042	1.00	24.46	C
ATOM	757	O	GLN		109	22.371	16.930	−99.901	1.00	23.21	O
ATOM	758	N	PHE		110	24.280	16.102	−99.075	1.00	26.35	N
ATOM	759	CA	PHE		110	23.999	16.618	−97.749	1.00	27.07	C
ATOM	760	CB	PHE		110	23.757	15.422	−96.824	1.00	23.12	C
ATOM	761	CG	PHE		110	22.789	14.414	−97.380	1.00	23.19	C
ATOM	762	CD1	PHE		110	23.205	13.120	−97.678	1.00	22.81	C
ATOM	763	CD2	PHE		110	21.465	14.754	−97.600	1.00	23.52	C
ATOM	764	CE1	PHE		110	22.309	12.181	−98.184	1.00	26.02	C
ATOM	765	CE2	PHE		110	20.562	13.828	−98.105	1.00	24.02	C
ATOM	766	CZ	PHE		110	20.984	12.538	−98.398	1.00	26.01	C
ATOM	767	C	PHE		110	24.949	17.589	−97.058	1.00	27.22	C
ATOM	768	O	PHE		110	24.619	18.102	−95.994	1.00	28.23	O
ATOM	769	N	SER		111	26.111	17.856	−97.628	1.00	21.97	N
ATOM	770	CA	SER		111	27.025	18.779	−96.970	1.00	22.53	C
ATOM	771	CB	SER		111	28.380	18.773	−97.654	1.00	17.83	C
ATOM	772	OG	SER		111	29.249	19.688	−97.017	1.00	19.51	O
ATOM	773	C	SER		111	26.481	20.215	−96.946	1.00	23.80	C
ATOM	774	O	SER		111	25.986	20.712	−97.958	1.00	23.31	O
ATOM	775	N	ASP		112	26.575	20.865	−95.785	1.00	29.48	N
ATOM	776	CA	ASP		112	26.108	22.239	−95.642	1.00	31.90	C
ATOM	777	CB	ASP		112	25.685	22.526	−94.200	1.00	22.62	C
ATOM	778	CG	ASP		112	24.300	22.004	−93.886	1.00	24.75	C
ATOM	779	OD1	ASP		112	23.367	22.343	−94.639	1.00	24.54	O
ATOM	780	OD2	ASP		112	24.135	21.261	−92.887	1.00	21.79	O
ATOM	781	C	ASP		112	27.188	23.223	−96.068	1.00	31.82	C
ATOM	782	O	ASP		112	27.185	24.385	−95.664	1.00	34.26	O
ATOM	783	N	CYS		113	28.124	22.746	−96.877	1.00	31.92	N
ATOM	784	CA	CYS		113	29.192	23.594	−97.383	1.00	31.08	C
ATOM	785	CB	CYS		113	30.562	22.952	−97.160	1.00	25.22	C
ATOM	786	SG	CYS		113	31.955	23.975	−97.700	1.00	27.72	S
ATOM	787	C	CYS		113	28.949	23.751	−98.869	1.00	31.17	C
ATOM	788	O	CYS		113	28.473	22.822	−99.525	1.00	30.96	O
ATOM	789	N	SER		114	29.263	24.927	−99.397	1.00	28.80	N
ATOM	790	CA	SER		114	29.087	25.191	−100.816	1.00	29.82	C
ATOM	791	CB	SER		114	29.491	26.633	−101.140	1.00	38.43	C
ATOM	792	OG	SER		114	30.796	26.921	−100.661	1.00	41.03	O
ATOM	793	C	SER		114	29.936	24.224	−101.635	1.00	29.28	C
ATOM	794	O	SER		114	29.662	23.999	−102.820	1.00	28.73	O
ATOM	795	N	SER		115	30.960	23.648	−101.001	1.00	24.09	N
ATOM	796	CA	SER		115	31.844	22.706	−101.684	1.00	23.71	C
ATOM	797	CB	SER		115	33.088	22.418	−100.833	1.00	27.10	C
ATOM	798	OG	SER		115	32.748	21.719	−99.650	1.00	27.68	O
ATOM	799	C	SER		115	31.129	21.397	−102.025	1.00	21.99	C
ATOM	800	O	SER		115	31.716	20.492	−102.626	1.00	21.19	O
ATOM	801	N	ALA		116	29.862	21.294	−101.640	1.00	23.30	N
ATOM	802	CA	ALA		116	29.076	20.106	−101.952	1.00	22.38	C
ATOM	803	CB	ALA		116	27.659	20.232	−101.355	1.00	20.06	C
ATOM	804	C	ALA		116	28.992	19.967	−103.482	1.00	24.14	C
ATOM	805	O	ALA		116	29.043	18.856	−104.022	1.00	20.21	O
ATOM	806	N	LYS		117	28.858	21.102	−104.172	1.00	18.10	N
ATOM	807	CA	LYS		117	28.768	21.109	−105.639	1.00	19.43	C
ATOM	808	CB	LYS		117	28.581	22.544	−106.145	1.00	40.55	C
ATOM	809	CG	LYS		117	27.420	23.281	−105.499	1.00	46.69	C
ATOM	810	CD	LYS		117	26.074	22.787	−106.011	1.00	48.91	C
ATOM	811	CE	LYS		117	24.919	23.335	−105.167	1.00	51.75	C
ATOM	812	NZ	LYS		117	24.908	22.757	−103.786	1.00	49.86	N
ATOM	813	C	LYS		117	30.012	20.500	−106.299	1.00	18.45	C
ATOM	814	O	LYS		117	30.001	20.193	−107.484	1.00	16.93	O
ATOM	815	N	ALA		118	31.091	20.359	−105.535	1.00	23.21	N
ATOM	816	CA	ALA		118	32.321	19.767	−106.055	1.00	24.27	C
ATOM	817	CB	ALA		118	33.497	20.735	−105.894	1.00	20.75	C
ATOM	818	C	ALA		118	32.609	18.471	−105.298	1.00	24.90	C
ATOM	819	O	ALA		118	33.764	18.111	−105.087	1.00	24.98	O
ATOM	820	N	ARG		119	31.547	17.787	−104.886	1.00	20.58	N
ATOM	821	CA	ARG		119	31.671	16.532	−104.143	1.00	23.45	C
ATOM	822	CB	ARG		119	32.263	15.435	−105.030	1.00	66.29	C
ATOM	823	CG	ARG		119	31.285	14.870	−106.044	1.00	69.42	C
ATOM	824	CD	ARG		119	31.987	14.071	−107.134	1.00	73.46	C
ATOM	825	NE	ARG		119	33.056	14.853	−107.746	1.00	79.80	N
ATOM	826	CZ	ARG		119	34.295	14.933	−107.268	1.00	79.85	C
ATOM	827	NH1	ARG		119	34.631	14.265	−106.171	1.00	81.46	N
ATOM	828	NH2	ARG		119	35.194	15.705	−107.868	1.00	75.54	N
ATOM	829	C	ARG		119	32.517	16.698	−102.893	1.00	22.59	C
ATOM	830	O	ARG		119	33.232	15.785	−102.490	1.00	20.53	O
ATOM	831	N	GLY		120	32.433	17.879	−102.290	1.00	24.63	N
ATOM	832	CA	GLY		120	33.168	18.135	−101.066	1.00	25.04	C
ATOM	833	C	GLY		120	34.628	18.504	−101.198	1.00	25.79	C
ATOM	834	O	GLY		120	35.252	18.875	−100.208	1.00	25.08	O
ATOM	835	N	ASP		121	35.182	18.412	−102.402	1.00	23.84	N
ATOM	836	CA	ASP		121	36.590	18.753	−102.606	1.00	23.82	C
ATOM	837	CB	ASP		121	37.008	18.467	−104.052	1.00	29.84	C
ATOM	838	CG	ASP		121	38.412	18.948	−104.352	1.00	30.81	C
ATOM	839	OD1	ASP		121	39.327	18.641	−103.554	1.00	28.96	O
ATOM	840	OD2	ASP		121	38.604	19.627	−105.388	1.00	29.97	O
ATOM	841	C	ASP		121	36.881	20.219	−102.283	1.00	25.41	C
ATOM	842	O	ASP		121	36.184	21.127	−102.750	1.00	24.07	O
ATOM	843	N	LEU		122	37.920	20.434	−101.484	1.00	27.52	N
ATOM	844	CA	LEU		122	38.321	21.774	−101.083	1.00	29.03	C
ATOM	845	CB	LEU		122	38.542	21.822	−99.573	1.00	23.19	C
ATOM	846	CG	LEU		122	37.317	21.590	−98.688	1.00	23.30	C
ATOM	847	CD1	LEU		122	37.763	21.498	−97.227	1.00	21.90	C
ATOM	848	CD2	LEU		122	36.328	22.728	−98.878	1.00	23.14	C
ATOM	849	C	LEU		122	39.599	22.227	−101.777	1.00	30.09	C
ATOM	850	O	LEU		122	40.024	23.367	−101.611	1.00	30.44	O
ATOM	851	N	GLY		123	40.210	21.341	−102.555	1.00	32.59	N
ATOM	852	CA	GLY		123	41.450	21.696	−103.216	1.00	33.34	C
ATOM	853	C	GLY		123	42.590	21.492	−102.240	1.00	34.46	C
ATOM	854	O	GLY		123	42.362	21.066	−101.105	1.00	35.29	O
ATOM	855	N	ALA		124	43.812	21.787	−102.663	1.00	27.21	N
ATOM	856	CA	ALA		124	44.972	21.619	−101.796	1.00	28.46	C
ATOM	857	CB	ALA		124	46.239	21.428	−102.629	1.00	25.86	C
ATOM	858	C	ALA		124	45.133	22.821	−100.874	1.00	29.68	C
ATOM	859	O	ALA		124	44.654	23.915	−101.176	1.00	30.17	O
ATOM	860	N	PHE		125	45.798	22.608	−99.745	1.00	29.96	N
ATOM	861	CA	PHE		125	46.018	23.677	−98.785	1.00	30.00	C
ATOM	862	CB	PHE		125	44.728	23.953	−97.983	1.00	32.26	C
ATOM	863	CG	PHE		125	44.198	22.757	−97.215	1.00	32.59	C
ATOM	864	CD1	PHE		125	44.777	22.365	−96.020	1.00	32.40	C
ATOM	865	CD2	PHE		125	43.101	22.042	−97.685	1.00	32.88	C
ATOM	866	CE1	PHE		125	44.275	21.281	−95.302	1.00	31.50	C
ATOM	867	CE2	PHE		125	42.593	20.959	−96.974	1.00	32.77	C
ATOM	868	CZ	PHE		125	43.183	20.579	−95.777	1.00	31.03	C
ATOM	869	C	PHE		125	47.175	23.327	−97.861	1.00	29.21	C
ATOM	870	O	PHE		125	47.582	22.164	−97.766	1.00	30.99	O
ATOM	871	N	SER		126	47.728	24.336	−97.201	1.00	30.91	N
ATOM	872	CA	SER		126	48.839	24.112	−96.280	1.00	31.80	C
ATOM	873	CB	SER		126	50.058	24.944	−96.692	1.00	48.97	C
ATOM	874	OG	SER		126	49.783	26.329	−96.585	1.00	50.37	O
ATOM	875	C	SER		126	48.381	24.522	−94.894	1.00	30.73	C
ATOM	876	O	SER		126	47.270	25.039	−94.731	1.00	29.97	O
ATOM	877	N	ARG		127	49.217	24.286	−93.891	1.00	36.37	N
ATOM	878	CA	ARG		127	48.849	24.660	−92.535	1.00	37.50	C
ATOM	879	CB	ARG		127	49.887	24.158	−91.528	1.00	33.85	C
ATOM	880	CG	ARG		127	49.804	22.673	−91.216	1.00	33.05	C
ATOM	881	CD	ARG		127	50.784	22.320	−90.116	1.00	31.66	C
ATOM	882	NE	ARG		127	50.733	20.912	−89.722	1.00	31.07	N
ATOM	883	CZ	ARG		127	49.761	20.363	−88.994	1.00	30.21	C
ATOM	884	NH1	ARG		127	48.740	21.097	−88.571	1.00	27.23	N
ATOM	885	NH2	ARG		127	49.825	19.078	−88.674	1.00	30.30	N
ATOM	886	C	ARG		127	48.738	26.174	−92.442	1.00	40.02	C
ATOM	887	O	ARG		127	49.542	26.900	−93.027	1.00	40.22	O
ATOM	888	N	GLY		128	47.729	26.645	−91.718	1.00	49.10	N
ATOM	889	CA	GLY		128	47.542	28.073	−91.558	1.00	50.77	C
ATOM	890	C	GLY		128	46.381	28.673	−92.328	1.00	50.83	C
ATOM	891	O	GLY		128	46.100	29.859	−92.182	1.00	52.90	O
ATOM	892	N	GLN		129	45.692	27.871	−93.134	1.00	35.80	N
ATOM	893	CA	GLN		129	44.578	28.389	−93.922	1.00	34.37	C
ATOM	894	CB	GLN		129	44.654	27.876	−95.359	1.00	36.06	C
ATOM	895	CG	GLN		129	46.045	27.850	−95.969	1.00	38.81	C
ATOM	896	CD	GLN		129	46.015	27.361	−97.407	1.00	40.11	C
ATOM	897	OE1	GLN		129	47.040	26.980	−97.972	1.00	41.71	O
ATOM	898	NE2	GLN		129	44.830	27.374	−98.008	1.00	42.73	N
ATOM	899	C	GLN		129	43.212	28.016	−93.367	1.00	33.12	C
ATOM	900	O	GLN		129	42.296	28.835	−93.343	1.00	33.22	O
ATOM	901	N	MET		130	43.081	26.766	−92.939	1.00	31.88	N
ATOM	902	CA	MET		130	41.821	26.252	−92.417	1.00	31.07	C
ATOM	903	CB	MET		130	41.676	24.772	−92.807	1.00	32.84	C
ATOM	904	CG	MET		130	41.901	24.480	−94.290	1.00	34.76	C
ATOM	905	SD	MET		130	40.640	25.172	−95.377	1.00	37.86	S
ATOM	906	CE	MET		130	41.211	24.584	−96.966	1.00	37.27	C
ATOM	907	C	MET		130	41.742	26.382	−90.897	1.00	30.31	C
ATOM	908	O	MET		130	42.746	26.653	−90.237	1.00	30.11	O
ATOM	909	N	GLN		131	40.542	26.200	−90.353	1.00	32.53	N
ATOM	910	CA	GLN		131	40.347	26.255	−88.910	1.00	33.04	C
ATOM	911	CB	GLN		131	38.870	26.066	−88.577	1.00	36.19	C
ATOM	912	CG	GLN		131	37.980	27.079	−89.287	1.00	38.94	C
ATOM	913	CD	GLN		131	36.508	26.907	−88.967	1.00	40.59	C
ATOM	914	OE1	GLN		131	36.084	27.078	−87.824	1.00	44.90	O
ATOM	915	NE2	GLN		131	35.718	26.562	−89.980	1.00	41.02	N
ATOM	916	C	GLN		131	41.195	25.120	−88.345	1.00	32.61	C
ATOM	917	O	GLN		131	41.216	24.012	−88.895	1.00	32.04	O
ATOM	918	N	LYS		132	41.899	25.410	−87.256	1.00	29.66	N
ATOM	919	CA	LYS		132	42.821	24.470	−86.620	1.00	27.83	C
ATOM	920	CB	LYS		132	43.259	25.030	−85.257	1.00	25.86	C
ATOM	921	CG	LYS		132	44.620	24.528	−84.784	1.00	25.88	C
ATOM	922	CD	LYS		132	45.722	24.992	−85.715	1.00	24.67	C
ATOM	923	CE	LYS		132	46.555	23.824	−86.265	1.00	25.54	C
ATOM	924	NZ	LYS		132	47.581	23.270	−85.331	1.00	26.89	N
ATOM	925	C	LYS		132	42.388	23.001	−86.470	1.00	27.14	C
ATOM	926	O	LYS		132	43.142	22.095	−86.829	1.00	26.64	O
ATOM	927	N	PRO		133	41.188	22.740	−85.926	1.00	22.57	N
ATOM	928	CD	PRO		133	40.154	23.659	−85.419	1.00	31.97	C
ATOM	929	CA	PRO		133	40.763	21.338	−85.776	1.00	24.04	C
ATOM	930	CB	PRO		133	39.349	21.463	−85.200	1.00	33.19	C
ATOM	931	CG	PRO		133	39.394	22.779	−84.455	1.00	33.49	C
ATOM	932	C	PRO		133	40.776	20.607	−87.123	1.00	23.70	C
ATOM	933	O	PRO		133	41.315	19.504	−87.246	1.00	23.13	O
ATOM	934	N	PHE		134	40.192	21.247	−88.132	1.00	27.49	N
ATOM	935	CA	PHE		134	40.128	20.689	−89.483	1.00	26.00	C
ATOM	936	CB	PHE		134	39.431	21.675	−90.413	1.00	24.79	C
ATOM	937	CG	PHE		134	38.965	21.077	−91.711	1.00	22.98	C
ATOM	938	CD1	PHE		134	37.680	20.567	−91.828	1.00	20.76	C
ATOM	939	CD2	PHE		134	39.791	21.066	−92.825	1.00	22.54	C
ATOM	940	CE1	PHE		134	37.219	20.058	−93.040	1.00	21.87	C
ATOM	941	CE2	PHE		134	39.340	20.559	−94.042	1.00	21.53	C
ATOM	942	CZ	PHE		134	38.053	20.056	−94.148	1.00	21.75	C
ATOM	943	C	PHE		134	41.544	20.448	−89.994	1.00	25.38	C
ATOM	944	O	PHE		134	41.860	19.375	−90.520	1.00	24.29	O
ATOM	945	N	GLU		135	42.393	21.462	−89.839	1.00	25.30	N
ATOM	946	CA	GLU		135	43.775	21.375	−90.289	1.00	24.08	C
ATOM	947	CB	GLU		135	44.534	22.653	−89.931	1.00	27.17	C
ATOM	948	CG	GLU		135	46.026	22.577	−90.198	1.00	29.36	C
ATOM	949	CD	GLU		135	46.743	23.855	−89.789	1.00	32.18	C
ATOM	950	OE1	GLU		135	46.274	24.947	−90.177	1.00	32.15	O
ATOM	951	OE2	GLU		135	47.768	23.764	−89.084	1.00	34.46	O
ATOM	952	C	GLU		135	44.506	20.185	−89.686	1.00	23.82	C
ATOM	953	O	GLU		135	45.047	19.344	−90.408	1.00	21.02	O
ATOM	954	N	ASP		136	44.532	20.125	−88.362	1.00	18.96	N
ATOM	955	CA	ASP		136	45.213	19.040	−87.667	1.00	18.64	C
ATOM	956	CB	ASP		136	45.053	19.182	−86.148	1.00	33.63	C
ATOM	957	CG	ASP		136	45.805	20.388	−85.594	1.00	33.64	C
ATOM	958	OD1	ASP		136	46.928	20.663	−86.083	1.00	33.59	O
ATOM	959	OD2	ASP		136	45.280	21.051	−84.672	1.00	34.58	O
ATOM	960	C	ASP		136	44.690	17.687	−88.122	1.00	17.27	C
ATOM	961	O	ASP		136	45.468	16.772	−88.387	1.00	17.39	O
ATOM	962	N	ALA		137	43.373	17.564	−88.227	1.00	23.61	N
ATOM	963	CA	ALA		137	42.791	16.300	−88.663	1.00	23.57	C
ATOM	964	CB	ALA		137	41.257	16.388	−88.629	1.00	24.33	C
ATOM	965	C	ALA		137	43.288	15.999	−90.081	1.00	23.57	C
ATOM	966	O	ALA		137	43.760	14.897	−90.369	1.00	22.96	O
ATOM	967	N	SER		138	43.208	16.997	−90.954	1.00	24.89	N
ATOM	968	CA	SER		138	43.639	16.841	−92.345	1.00	25.57	C
ATOM	969	CB	SER		138	43.480	18.156	−93.101	1.00	19.03	C
ATOM	970	OG	SER		138	42.123	18.530	−93.165	1.00	17.05	O
ATOM	971	C	SER		138	45.064	16.356	−92.506	1.00	26.91	C
ATOM	972	O	SER		138	45.321	15.430	−93.277	1.00	25.54	O
ATOM	973	N	PHE		139	45.991	16.977	−91.782	1.00	24.01	N
ATOM	974	CA	PHE		139	47.400	16.605	−91.861	1.00	25.68	C
ATOM	975	CB	PHE		139	48.286	17.766	−91.391	1.00	33.43	C
ATOM	976	CG	PHE		139	48.501	18.818	−92.442	1.00	33.62	C
ATOM	977	CD1	PHE		139	47.519	19.754	−92.718	1.00	33.08	C
ATOM	978	CD2	PHE		139	49.657	18.821	−93.206	1.00	35.11	C
ATOM	979	CE1	PHE		139	47.682	20.676	−93.742	1.00	34.16	C
ATOM	980	CE2	PHE		139	49.827	19.740	−94.234	1.00	34.09	C
ATOM	981	CZ	PHE		139	48.836	20.666	−94.502	1.00	33.18	C
ATOM	982	C	PHE		139	47.789	15.334	−91.105	1.00	26.85	C
ATOM	983	O	PHE		139	48.869	14.787	−91.322	1.00	27.55	O
ATOM	984	N	ALA		140	46.924	14.873	−90.210	1.00	26.06	N
ATOM	985	CA	ALA		140	47.209	13.660	−89.461	1.00	25.55	C
ATOM	986	CB	ALA		140	46.531	13.716	−88.101	1.00	19.65	C
ATOM	987	C	ALA		140	46.704	12.463	−90.267	1.00	25.79	C
ATOM	988	O	ALA		140	47.124	11.322	−90.049	1.00	24.80	O
ATOM	989	N	LEU		141	45.806	12.729	−91.211	1.00	30.05	N
ATOM	990	CA	LEU		141	45.269	11.669	−92.056	1.00	30.74	C
ATOM	991	CB	LEU		141	44.015	12.152	−92.794	1.00	25.73	C
ATOM	992	CG	LEU		141	42.714	12.337	−92.007	1.00	25.32	C
ATOM	993	CD1	LEU		141	41.685	13.045	−92.878	1.00	22.31	C
ATOM	994	CD2	LEU		141	42.188	10.974	−91.558	1.00	24.22	C
ATOM	995	C	LEU		141	46.298	11.229	−93.086	1.00	32.06	C
ATOM	996	O	LEU		141	47.136	12.019	−93.522	1.00	32.47	O
ATOM	997	N	ARG		142	46.251	9.959	−93.464	1.00	24.26	N
ATOM	998	CA	ARG		142	47.152	9.464	−94.493	1.00	24.58	C
ATOM	999	CB	ARG		142	47.529	8.008	−94.216	1.00	91.42	C
ATOM	1000	CG	ARG		142	48.475	7.856	−93.033	1.00	91.49	C
ATOM	1001	CD	ARG		142	48.876	6.410	−92.811	1.00	95.06	C
ATOM	1002	NE	ARG		142	47.814	5.629	−92.184	1.00	97.55	N
ATOM	1003	CZ	ARG		142	47.399	5.803	−90.934	1.00	97.12	C
ATOM	1004	NH1	ARG		142	47.956	6.735	−90.172	1.00	96.19	N
ATOM	1005	NH2	ARG		142	46.428	5.046	−90.443	1.00	96.04	N
ATOM	1006	C	ARG		142	46.355	9.597	−95.787	1.00	25.25	C
ATOM	1007	O	ARG		142	45.141	9.771	−95.744	1.00	23.99	O
ATOM	1008	N	THR		143	47.024	9.555	−96.930	1.00	28.86	N
ATOM	1009	CA	THR		143	46.321	9.673	−98.199	1.00	28.89	C
ATOM	1010	CB	THR		143	47.289	9.572	−99.388	1.00	27.35	C
ATOM	1011	OG1	THR		143	48.181	10.690	−99.370	1.00	31.19	O
ATOM	1012	CG2	THR		143	46.514	9.562	−100.704	1.00	26.93	C
ATOM	1013	C	THR		143	45.304	8.547	−98.324	1.00	28.31	C
ATOM	1014	O	THR		143	45.631	7.391	−98.070	1.00	25.80	O
ATOM	1015	N	GLY		144	44.076	8.890	−98.706	1.00	21.78	N
ATOM	1016	CA	GLY		144	43.038	7.886	−98.866	1.00	22.57	C
ATOM	1017	C	GLY		144	42.216	7.635	−97.615	1.00	21.55	C
ATOM	1018	O	GLY		144	41.121	7.070	−97.685	1.00	22.10	O
ATOM	1019	N	GLU		145	42.738	8.077	−96.473	1.00	26.69	N
ATOM	1020	CA	GLU		145	42.088	7.889	−95.181	1.00	26.01	C
ATOM	1021	CB	GLU		145	43.151	7.938	−94.080	1.00	30.85	C
ATOM	1022	CG	GLU		145	42.617	7.803	−92.673	1.00	34.28	C
ATOM	1023	CD	GLU		145	43.702	7.419	−91.677	1.00	36.90	C
ATOM	1024	OE1	GLU		145	44.905	7.554	−92.020	1.00	37.05	O
ATOM	1025	OE2	GLU		145	43.346	6.985	−90.552	1.00	35.71	O
ATOM	1026	C	GLU		145	40.946	8.863	−94.864	1.00	24.84	C
ATOM	1027	O	GLU		145	40.868	9.971	−95.404	1.00	25.13	O
ATOM	1028	N	MET		146	40.061	8.440	−93.972	1.00	20.35	N
ATOM	1029	CA	MET		146	38.920	9.256	−93.596	1.00	20.47	C
ATOM	1030	CB	MET		146	37.619	8.579	−94.059	1.00	23.06	C
ATOM	1031	CG	MET		146	36.365	9.414	−93.810	1.00	21.37	C
ATOM	1032	SD	MET		146	34.844	8.679	−94.440	1.00	21.15	S
ATOM	1033	CE	MET		146	34.428	7.537	−93.095	1.00	20.79	C
ATOM	1034	C	MET		146	38.885	9.506	−92.091	1.00	20.26	C
ATOM	1035	O	MET		146	39.256	8.648	−91.288	1.00	17.10	O
ATOM	1036	N	SER		147	38.425	10.691	−91.716	1.00	17.48	N
ATOM	1037	CA	SER		147	38.351	11.070	−90.315	1.00	16.86	C
ATOM	1038	CB	SER		147	38.440	12.589	−90.177	1.00	16.80	C
ATOM	1039	OG	SER		147	37.153	13.158	−90.430	1.00	17.03	O
ATOM	1040	C	SER		147	37.031	10.648	−89.686	1.00	16.63	C
ATOM	1041	O	SER		147	36.119	10.187	−90.368	1.00	15.19	O
ATOM	1042	N	GLY		148	36.953	10.817	−88.371	1.00	19.57	N
ATOM	1043	CA	GLY		148	35.722	10.565	−87.654	1.00	21.69	C
ATOM	1044	C	GLY		148	35.139	11.969	−87.548	1.00	22.31	C
ATOM	1045	O	GLY		148	35.592	12.869	−88.271	1.00	21.73	O
ATOM	1046	N	PRO		149	34.147	12.202	−86.682	1.00	24.08	N
ATOM	1047	CD	PRO		149	33.394	11.222	−85.881	1.00	24.18	C
ATOM	1048	CA	PRO		149	33.576	13.546	−86.561	1.00	23.27	C
ATOM	1049	CB	PRO		149	32.468	13.364	−85.521	1.00	25.65	C
ATOM	1050	CG	PRO		149	32.054	11.910	−85.706	1.00	26.28	C
ATOM	1051	C	PRO		149	34.628	14.556	−86.103	1.00	23.78	C
ATOM	1052	O	PRO		149	35.289	14.347	−85.083	1.00	21.81	O
ATOM	1053	N	VAL		150	34.779	15.645	−86.857	1.00	19.30	N
ATOM	1054	CA	VAL		150	35.749	16.702	−86.526	1.00	19.47	C
ATOM	1055	CB	VAL		150	36.761	16.918	−87.673	1.00	19.26	C
ATOM	1056	CG1	VAL		150	37.640	18.144	−87.386	1.00	17.57	C
ATOM	1057	CG2	VAL		150	37.631	15.683	−87.826	1.00	20.26	C
ATOM	1058	C	VAL		150	34.982	18.002	−86.272	1.00	20.31	C
ATOM	1059	O	VAL		150	34.231	18.469	−87.132	1.00	19.82	O
ATOM	1060	N	PHE		151	35.184	18.584	−85.090	1.00	20.39	N
ATOM	1061	CA	PHE		151	34.466	19.794	−84.707	1.00	22.47	C
ATOM	1062	CB	PHE		151	34.045	19.696	−83.234	1.00	21.83	C
ATOM	1063	CG	PHE		151	33.243	18.466	−82.908	1.00	22.44	C
ATOM	1064	CD1	PHE		151	33.862	17.228	−82.781	1.00	20.93	C
ATOM	1065	CD2	PHE		151	31.873	18.547	−82.719	1.00	22.17	C
ATOM	1066	CE1	PHE		151	33.126	16.095	−82.467	1.00	22.60	C
ATOM	1067	CE2	PHE		151	31.128	17.414	−82.407	1.00	22.25	C
ATOM	1068	CZ	PHE		151	31.757	16.185	−82.281	1.00	20.64	C
ATOM	1069	C	PHE		151	35.202	21.124	−84.923	1.00	23.15	C
ATOM	1070	O	PHE		151	36.380	21.258	−84.590	1.00	24.15	O
ATOM	1071	N	THR		152	34.487	22.093	−85.487	1.00	21.62	N
ATOM	1072	CA	THR		152	35.015	23.439	−85.729	1.00	22.22	C
ATOM	1073	C	THR		152	35.454	23.660	−87.200	1.00	19.34	C
ATOM	1074	OG1	THR		152	34.288	23.689	−88.032	1.00	19.26	O
ATOM	1075	CG2	THR		152	36.414	22.565	−87.671	1.00	20.08	C
ATOM	1076	C	THR		152	33.847	24.394	−85.478	1.00	21.91	C
ATOM	1077	O	THR		152	32.705	23.955	−85.303	1.00	21.69	O
ATOM	1078	N	ASP		153	34.118	25.695	−85.495	1.00	31.72	N
ATOM	1079	CA	ASP		153	33.057	26.672	−85.290	1.00	33.90	C
ATOM	1080	CB	ASP		153	33.646	28.078	−85.172	1.00	48.59	C
ATOM	1081	CG	ASP		153	34.545	28.223	−83.965	1.00	51.94	C
ATOM	1082	OD1	ASP		153	34.118	27.817	−82.867	1.00	53.41	O
ATOM	1083	OD2	ASP		153	35.672	28.740	−84.108	1.00	55.50	O
ATOM	1084	C	ASP		153	32.068	26.627	−86.443	1.00	33.62	C
ATOM	1085	O	ASP		153	30.960	27.157	−86.356	1.00	35.14	O
ATOM	1086	N	SER		154	32.471	25.983	−87.530	1.00	26.57	N
ATOM	1087	CA	SER		154	31.617	25.892	−88.697	1.00	25.03	C
ATOM	1088	CB	SER		154	32.493	25.627	−89.921	1.00	39.88	C
ATOM	1089	OG	SER		154	31.766	25.822	−91.106	1.00	42.24	O
ATOM	1090	C	SER		154	30.552	24.794	−88.523	1.00	24.18	C
ATOM	1091	O	SER		154	29.434	24.898	−89.043	1.00	21.98	O
ATOM	1092	N	GLY		155	30.901	23.753	−87.774	1.00	26.13	N
ATOM	1093	CA	GLY		155	29.973	22.655	−87.541	1.00	24.99	C
ATOM	1094	C	GLY		155	30.729	21.359	−87.314	1.00	23.98	C
ATOM	1095	O	GLY		155	31.809	21.362	−86.711	1.00	24.78	O
ATOM	1096	N	ILE		156	30.171	20.251	−87.794	1.00	21.74	N
ATOM	1097	CA	ILE		156	30.808	18.939	−87.658	1.00	20.36	C
ATOM	1098	CB	ILE		156	29.858	17.933	−86.977	1.00	24.45	C
ATOM	1099	CG2	ILE		156	30.611	16.652	−86.620	1.00	26.10	C
ATOM	1100	CG1	ILE		156	29.286	18.538	−85.694	1.00	24.15	C
ATOM	1101	CD1	ILE		156	28.263	17.651	−84.996	1.00	23.18	C
ATOM	1102	C	ILE		156	31.166	18.422	−89.061	1.00	20.95	C
ATOM	1103	O	ILE		156	30.324	18.417	−89.965	1.00	19.91	O
ATOM	1104	N	HIS		157	32.408	17.985	−89.246	1.00	19.04	N
ATOM	1105	CA	HIS		157	32.831	17.495	−90.559	1.00	20.27	C
ATOM	1106	CB	HIS		157	33.990	18.324	−91.147	1.00	35.74	C
ATOM	1107	CG	HIS		157	34.007	19.771	−90.759	1.00	37.67	C
ATOM	1108	CD2	HIS		157	33.712	20.396	−89.594	1.00	37.63	C
ATOM	1109	ND1	HIS		157	34.491	20.747	−91.604	1.00	36.18	N
ATOM	1110	CE1	HIS		157	34.496	21.909	−90.976	1.00	39.43	C
ATOM	1111	NE2	HIS		157	34.029	21.723	−89.754	1.00	37.74	N
ATOM	1112	C	HIS		157	33.331	16.043	−90.582	1.00	20.24	C
ATOM	1113	O	HIS		157	33.745	15.491	−89.561	1.00	20.37	O
ATOM	1114	N	ILE		158	33.289	15.457	−91.777	1.00	20.22	N
ATOM	1115	CA	ILE		158	33.829	14.135	−92.035	1.00	19.41	C
ATOM	1116	CB	ILE		158	32.831	13.181	−92.710	1.00	19.81	C
ATOM	1117	CG2	ILE		158	33.540	11.878	−93.086	1.00	20.72	C
ATOM	1118	CG1	ILE		158	31.670	12.867	−91.772	1.00	19.97	C
ATOM	1119	CD1	ILE		158	30.542	12.114	−92.449	1.00	20.76	C
ATOM	1120	C	ILE		158	34.881	14.542	−93.066	1.00	19.80	C
ATOM	1121	O	ILE		158	34.553	15.207	−94.051	1.00	20.12	O
ATOM	1122	N	ILE		159	36.135	14.173	−92.840	1.00	17.51	N
ATOM	1123	CA	ILE		159	37.196	14.565	−93.765	1.00	19.25	C
ATOM	1124	CB	ILE		159	38.303	15.373	−93.027	1.00	19.91	C
ATOM	1125	CG2	ILE		159	39.316	15.911	−94.021	1.00	21.46	C
ATOM	1126	CG1	ILE		159	37.679	16.545	−92.267	1.00	22.20	C
ATOM	1127	CD1	ILE		159	38.679	17.343	−91.410	1.00	18.54	C
ATOM	1128	C	ILE		159	37.855	13.386	−94.479	1.00	18.91	C
ATOM	1129	O	ILE		159	38.172	12.367	−93.862	1.00	20.65	O
ATOM	1130	N	LEU		160	38.043	13.536	−95.787	1.00	19.50	N
ATOM	1131	CA	LEU		160	38.689	12.506	−96.600	1.00	20.02	C
ATOM	1132	CB	LEU		160	37.749	12.011	−97.699	1.00	19.07	C
ATOM	1133	CG	LEU		160	38.337	10.959	−98.648	1.00	20.92	C
ATOM	1134	CD1	LEU		160	38.496	9.619	−97.905	1.00	21.52	C
ATOM	1135	CD2	LEU		160	37.412	10.783	−99.851	1.00	19.86	C
ATOM	1136	C	LEU		160	39.926	13.110	−97.249	1.00	20.20	C
ATOM	1137	O	LEU		160	39.834	14.070	−98.013	1.00	21.45	O
ATOM	1138	N	ARG		161	41.092	12.571	−96.934	1.00	22.38	N
ATOM	1139	CA	ARG		161	42.296	13.100	−97.535	1.00	23.38	C
ATOM	1140	CB	ARG		161	43.510	12.872	−96.639	1.00	28.22	C
ATOM	1141	CG	ARG		161	44.757	13.479	−97.249	1.00	31.35	C
ATOM	1142	CD	ARG		161	46.024	13.171	−96.481	1.00	33.89	C
ATOM	1143	NE	ARG		161	47.180	13.566	−97.279	1.00	33.83	N
ATOM	1144	CZ	ARG		161	48.446	13.361	−96.933	1.00	36.18	C
ATOM	1145	NH1	ARG		161	48.742	12.762	−95.783	1.00	35.10	N
ATOM	1146	NH2	ARG		161	49.419	13.744	−97.752	1.00	34.40	N
ATOM	1147	C	ARG		161	42.485	12.406	−98.877	1.00	22.99	C
ATOM	1148	O	ARG		161	42.590	11.181	−98.948	1.00	23.07	O
ATOM	1149	N	THR		162	42.511	13.197	−99.942	1.00	21.36	N
ATOM	1150	CA	THR		162	42.659	12.657	−101.279	1.00	23.18	C
ATOM	1151	CB	THR		162	41.703	13.371	−102.253	1.00	23.83	C
ATOM	1152	OG1	THR		162	41.915	14.788	−102.184	1.00	24.52	O
ATOM	1153	CG2	THR		162	40.262	13.068	−101.892	1.00	24.17	C
ATOM	1154	C	THR		162	44.085	12.733	−101.825	1.00	23.58	C
ATOM	1155	O	THR		162	44.439	11.975	−102.723	1.00	23.23	O
ATOM	1156	N	GLU		163	44.893	13.649	−101.296	1.00	23.52	N
ATOM	1157	CA	GLU		163	46.283	13.803	−101.741	1.00	25.66	C
ATOM	1158	CB	GLU		163	46.378	14.795	−102.908	1.00	30.58	C
ATOM	1159	CG	GLU		163	45.654	14.387	−104.176	1.00	32.82	C
ATOM	1160	CD	GLU		163	45.797	15.425	−105.276	1.00	34.85	C
ATOM	1161	OE1	GLU		163	45.184	15.248	−106.352	1.00	35.37	O
ATOM	1162	OE2	GLU		163	46.525	16.420	−105.064	1.00	35.76	O
ATOM	1163	C	GLU		163	47.174	14.319	−100.615	1.00	26.53	C
ATOM	1164	O	GLU		163	46.634	14.906	−99.654	1.00	27.33	O
ATOM	1165	OXT	GLU		163	48.407	14.164	−100.722	1.00	29.79	O
TER	1166		GLU		163
ATOM	1167	OH2	TIP	B	1	37.065	26.124	−85.500	1.00	38.20	O
ATOM	1168	OH2	TIP	B	2	37.869	28.739	−86.179	1.00	56.84	O
ATOM	1169	OH2	TIP	B	3	39.402	13.911	−80.303	1.00	27.85	O
ATOM	1170	OH2	TIP	B	4	25.496	19.618	−104.419	1.00	29.09	O
ATOM	1171	OH2	TIP	B	5	39.472	16.042	−102.531	1.00	22.42	O
ATOM	1172	OH2	TIP	B	6	34.887	0.262	−93.842	1.00	26.47	O
ATOM	1173	OH2	TIP	B	7	31.168	19.693	−98.752	1.00	21.68	O
ATOM	1174	OH2	TIP	B	8	45.776	8.755	−89.647	1.00	24.32	O
ATOM	1175	OH2	TIP	B	9	43.289	8.931	−88.556	1.00	26.13	O
ATOM	1176	OH2	TIP	B	10	31.088	18.908	−109.784	1.00	26.50	O
ATOM	1177	OH2	TIP	B	11	35.457	14.852	−103.096	1.00	31.26	O
ATOM	1178	OH2	TIP	B	12	32.512	3.897	−99.210	1.00	23.08	O
ATOM	1179	OH2	TIP	B	13	22.393	16.247	−93.167	1.00	38.13	O
ATOM	1180	OH2	TIP	B	14	29.726	6.333	−87.054	1.00	29.72	O
ATOM	1181	OH2	TIP	B	15	44.926	24.966	−92.876	1.00	32.68	O
ATOM	1182	OH2	TIP	B	16	22.894	10.216	−91.185	1.00	31.32	O
ATOM	1183	OH2	TIP	B	17	29.107	17.255	−106.663	1.00	30.24	O
ATOM	1184	OH2	TIP	B	18	37.057	1.007	−89.526	1.00	25.11	O
ATOM	1185	OH2	TIP	B	19	20.970	21.419	−93.904	1.00	32.11	O
ATOM	1186	OH2	TIP	B	20	39.881	17.796	−82.737	1.00	42.56	O
ATOM	1187	OH2	TIP	B	21	34.645	2.593	−84.241	1.00	23.58	O
ATOM	1188	OH2	TIP	B	22	19.532	13.900	−101.840	1.00	38.82	O
ATOM	1189	OH2	TIP	B	23	41.754	−5.394	−83.388	1.00	24.68	O
ATOM	1190	OH2	TIP	B	24	35.589	7.272	−83.796	1.00	31.95	O
ATOM	1191	OH2	TIP	B	25	31.364	8.255	−85.956	1.00	44.18	O
ATOM	1192	OH2	TIP	B	26	47.929	17.330	−87.402	1.00	30.73	O
ATOM	1193	OH2	TIP	B	28	23.283	18.659	−93.681	1.00	34.98	O
ATOM	1194	OH2	TIP	B	29	20.270	12.799	−94.753	1.00	35.08	O
ATOM	1195	OH2	TIP	B	30	42.049	4.938	−91.169	1.00	27.29	O
ATOM	1196	OH2	TIP	B	31	50.300	16.102	−100.320	1.00	43.56	O
ATOM	1197	OH2	TIP	B	32	18.990	34.588	−95.754	1.00	42.95	O
ATOM	1198	OH2	TIP	B	33	43.024	16.973	−81.210	1.00	56.78	O
ATOM	1199	OH2	TIP	B	34	16.466	35.597	−98.387	1.00	46.94	O
ATOM	1200	OH2	TIP	B	36	48.313	17.969	−102.901	1.00	48.26	O
ATOM	1201	OH2	TIP	B	37	19.619	19.190	−99.935	1.00	45.81	O
ATOM	1202	OH2	TIP	B	38	15.428	27.959	−93.465	1.00	48.10	O
ATOM	1203	OH2	TIP	B	39	18.933	17.576	−79.666	1.00	48.75	O
ATOM	1204	OH2	TIP	B	40	23.029	8.242	−86.377	1.00	49.04	O
ATOM	1205	OH2	TIP	B	42	46.906	4.177	−94.935	1.00	45.70	O
ATOM	1206	OH2	TIP	B	43	19.911	13.874	−86.366	1.00	40.92	O
ATOM	1207	OH2	TIP	B	44	37.973	−1.485	−88.793	1.00	23.99	O
ATOM	1208	OH2	TIP	B	45	39.343	15.086	−104.928	1.00	27.19	O
ATOM	1209	OH2	TIP	B	46	20.852	9.599	−95.956	1.00	62.80	O
ATOM	1210	OH2	TIP	B	47	40.525	5.715	−93.227	1.00	24.44	O
ATOM	1211	OH2	TIP	B	48	17.749	17.649	−90.193	1.00	40.14	O
ATOM	1212	OH2	TIP	B	50	41.006	−9.309	−84.018	1.00	33.61	O
ATOM	1213	OH2	TIP	B	51	42.068	−8.017	−79.417	1.00	59.93	O
ATOM	1214	OH2	TIP	B	53	37.528	20.043	−107.955	1.00	44.18	O
ATOM	1215	OH2	TIP	B	55	39.439	12.383	−105.120	1.00	44.54	O
ATOM	1216	OH2	TIP	B	56	50.462	9.178	−96.912	1.00	42.35	O
ATOM	1217	OH2	TIP	B	58	19.361	16.611	−93.332	1.00	50.02	O
ATOM	1218	OH2	TIP	B	59	49.469	11.983	−92.574	1.00	44.09	O
ATOM	1219	OH2	TIP	B	60	38.286	30.094	−82.714	1.00	48.37	O
ATOM	1220	OH2	TIP	B	61	43.411	19.888	−82.885	1.00	55.87	O
ATOM	1221	OH2	TIP	B	62	30.427	10.544	−82.269	1.00	38.77	O
ATOM	1222	OH2	TIP	B	63	36.120	−2.889	−90.071	1.00	44.94	O
ATOM	1223	OH2	TIP	B	64	19.472	11.287	−87.779	1.00	49.41	O
ATOM	1224	OH2	TIP	B	66	13.631	33.639	−97.998	1.00	38.53	O
ATOM	1225	OH2	TIP	B	67	32.535	−0.911	−83.821	1.00	30.38	O
ATOM	1226	OH2	TIP	B	68	33.471	6.370	−99.916	1.00	35.36	O
ATOM	1227	OH2	TIP	B	69	38.816	6.344	−96.551	1.00	25.15	O
ATOM	1228	OH2	TIP	B	71	45.004	27.148	−88.921	1.00	37.88	O
ATOM	1229	OH2	TIP	B	72	49.231	21.517	−84.437	1.00	42.41	O
ATOM	1230	OH2	TIP	B	73	46.459	−5.431	−83.135	1.00	43.09	O
ATOM	1231	OH2	TIP	B	74	36.089	6.660	−96.786	1.00	27.41	O
ATOM	1232	OH2	TIP	B	77	49.839	15.344	−87.629	1.00	43.91	O
ATOM	1233	OH2	TIP	B	79	37.577	20.201	−82.541	1.00	30.78	O
ATOM	1234	OH2	TIP	B	82	28.801	2.482	−85.775	1.00	44.90	O
ATOM	1235	OH2	TIP	B	84	30.581	21.992	−84.159	1.00	34.07	O
ATOM	1236	OH2	TIP	B	86	45.141	28.886	−86.683	1.00	37.05	O
ATOM	1237	OH2	TIP	B	87	42.296	24.701	−101.906	1.00	42.10	O
ATOM	1238	OH2	TIP	B	89	31.576	5.059	−82.942	1.00	62.83	O
TER	1239		TIP	B	89
ATOM	1240	O1	PGB	C	180	33.597	3.812	−81.362	1.00	41.90	O
ATOM	1241	C2	PGB	C	180	34.348	2.942	−80.636	1.00	42.07	C
ATOM	1242	C3	PGB	C	180	34.065	1.486	−81.048	1.00	38.61	C
ATOM	1243	O4	PGB	C	180	34.810	1.144	−82.101	1.00	37.47	O
ATOM	1244	C5	PGB	C	180	35.357	−0.070	−81.989	1.00	31.75	C
ATOM	1245	C6	PGB	C	180	36.199	−0.358	−83.248	1.00	29.30	C
ATOM	1246	O7	PGB	C	180	35.413	−0.258	−84.351	1.00	29.20	O
ATOM	1247	C8	PGB	C	180	36.097	−0.485	−85.493	1.00	24.87	C
ATOM	1248	C9	PGB	C	180	35.144	−0.360	−86.704	1.00	25.69	C
ATOM	1249	O10	PGB	C	180	34.261	0.652	−86.495	1.00	24.77	O
ATOM	1250	C11	PGB	C	180	33.399	0.809	−87.522	1.00	24.67	C
ATOM	1251	C12	PGB	C	180	32.469	2.010	−87.230	1.00	26.91	C
ATOM	1252	O13	PGB	C	180	33.125	3.184	−87.399	1.00	25.33	O
ATOM	1253	C14	PGB	C	180	32.381	4.208	−86.939	1.00	28.12	C
ATOM	1254	C15	PGB	C	180	33.280	5.432	−86.597	1.00	26.06	C
ATOM	1255	O16	PGB	C	180	34.151	5.712	−87.590	1.00	28.17	O
ATOM	1256	C17	PGB	C	180	34.869	6.738	−87.233	1.00	29.17	C
ATOM	1257	C18	PGB	C	180	35.893	7.149	−88.294	1.00	30.74	C
ATOM	1258	O19	PGB	C	180	36.761	6.174	−88.418	1.00	31.21	O
ATOM	1259	C20	PGB	C	180	37.403	6.346	−89.539	1.00	32.26	C
ATOM	1260	C21	PGB	C	180	38.505	5.661	−90.335	1.00	34.94	C
ATOM	1261	O22	PGB	C	180	38.048	4.486	−90.698	1.00	36.18	O
TER	1262		PGB	C	180
ATOM	1263	O1	CRY	$	1101	37.898	25.387	−91.926	1.00	20.17	O
ATOM	1264	O2	CRY	$	1101	34.697	24.657	−93.373	1.00	20.17	O
ATOM	1265	O3	CRY	$	1101	35.992	25.052	−95.950	1.00	20.17	O
ATOM	1266	C1	CRY	$	1101	36.903	24.469	−92.384	1.00	20.17	C
ATOM	1267	C2	CRY	$	1101	36.083	25.052	−93.517	1.00	20.17	C
ATOM	1268	C3	CRY	$	1101	36.682	24.557	−94.810	1.00	20.17	C
ATOM	1269	C1	CIT	$	1003	30.016	28.736	−90.970	1.00	20.17	C
ATOM	1270	O1	CIT	$	1003	29.414	28.081	−90.022	1.00	20.17	O
ATOM	1271	O2	CIT	$	1003	30.673	29.785	−90.703	1.00	20.17	O
ATOM	1272	C2	CIT	$	1003	29.868	28.186	−92.378	1.00	20.17	C
ATOM	1273	C3	CIT	$	1003	30.917	28.433	−93.455	1.00	20.17	C
ATOM	1274	O7	CIT	$	1003	30.314	29.340	−94.480	1.00	20.17	O
ATOM	1275	C4	CIT	$	1003	31.340	27.135	−94.080	1.00	20.17	C
ATOM	1276	C5	CIT	$	1003	32.332	27.138	−95.191	1.00	20.17	C
ATOM	1277	O3	CIT	$	1003	33.171	28.011	−95.494	1.00	20.17	O
ATOM	1278	O4	CIT	$	1003	32.305	26.147	−95.937	1.00	20.17	O
ATOM	1279	C6	CIT	$	1003	32.174	29.273	−93.057	1.00	20.17	C
ATOM	1280	O5	CIT	$	1003	32.708	28.874	−91.920	1.00	20.17	O
ATOM	1281	O6	CIT	$	1003	32.467	30.177	−93.904	1.00	20.17	O

Example 5

Sequence Alignment of Pin1 and Pin1 Like Polypeptides to Determine Conserved Residues

[0202] The following sequence alignment was done using Eukaryotic metazoa species, where presumably the Pin1 protein serves the same purpose in each organism. Residues determined not to be conserved are not absolutely critical to the unique characteristics of Pin1 in these systems. Additional alignments that build up the specificity template include: i) comparing all human proline isomerases (hPin1, hPin4, all cylcophilins, all FKBP's, and any other misc. theoretical proteins); ii) comparing Pin1 with distantly related phosphoserine-proline specific proline isomerases; iii) others—depending on the question to be addressed.

[0203] Sequence alignment of Eukaryotic Metazoa: Cross-species alignment indicates residues essential for general Pin1 function.

Equivalents

[0204] Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments and methods described herein. Such equivalents are intended to be encompassed by the scope of the following claims.

Claims

1. A method of designing specific inhibitors of a Pin1 polypeptide, comprising the steps of: (a) determining the three-dimensional structures of crystallized Pin1 polypeptides in complex with small molecules; (b) employing the three-dimensional structures from step (a) to form an interaction template; (c) employing sequence and structural alignments to identify conserved amino acids among proline isomerases and distinguishing those amino acids that are specific to Pin1 to define a specificity template; (d) using the interaction template and the specificity template in conjunction with molecular modeling to design inhibitors specific to Pin1 or Pin1-like proline isomerases; and (e) determining the affinity and specificity of the inhibitors to Pin1.

2. A method for designing or selecting an inhibitor of a Pin1 polypeptide, comprising the steps of: a) using a three dimensional structure of a crystallized Pin1 polypeptide having a substitution, deletion or insertion of one or more amino acids of the sequence set forth in SEQ ID NO:1 to form a Pin1 interaction template; and b) employing the Pin1 interaction template to design or select the Pin1 inhibitor.

3. The method of claim 2, wherein the crystallized Pin1 polypeptide has a substitution, insertion or deletion of one or more amino acids within the WW-domain of the Pin-1 polypeptide.

4. The method of claim 3, wherein the crystallized Pin1 polypeptide has one amino acid substitution.

5. The method of claim 4, wherein the amino acid substitution of the crystallized Pin1 polypeptide is at position 14 of the amino acid sequence set forth in SEQ ID NO:1.

6. The method of claim 5, wherein the amino acid substitution at position 14 of the crystallized Pin1 polypeptide is a nonpolar amino acid.

7. The method of claim 6, wherein the nonpolar amino acid at position 14 is alanine.

8. The method of claim 2, wherein the crystallized Pin1 polypeptide further comprises a small molecule within the active site of the Pin1 polypeptide.

9. The method of claim 2, wherein the three dimensional structure of more than one crystallized Pin1 polypeptide is used to form the Pin1 interaction template.

10. The method of claim 2, wherein the three dimensional structure of more than one crystallized Pin1 polypeptide comprising a small molecule within the active site of the Pin1 polypeptide is used to form the Pin1 interaction template.

11. The method of claim 2, further comprising the step of using a Pin1 specificity template.

12. The method of claim 2, further comprising the step of contacting the inhibitor with a Pin1 polypeptide in the presence of a substrate to determine the ability of the inhibitor to inhibit the Pin1 polypeptide.

13. The method of claim 2, 7 or 8, further comprising the step of determining the affinity and specificity of the inhibitor.

14. The method according to claims 1 or 2, wherein said inhibitor is designed or selected de novo.

15. The method according to claims 1 or 2, wherein said inhibitor is designed or selected from a known inhibitor.

16. The method according to claims 1 or 2, wherein said three-dimensional structure is used to design or select chemical entities or fragments that bind to at least one of the following portions of the Pin1 active site: the hydrophobic pocket, the cysteine/scrine valley, the phosphate binding pocket, the substrate grove and the lip regions.

17. The method of claim 16, wherein the identified chemical entities or fragments are covalently linked.

18. The method according to anyone of claims 1 or 2 wherein said inhibitor is a competitive inhibitor of Pin1.

19. The method according to anyone of claims 1 or 2 wherein said inhibitor is a non-competitive or uncompetitive inhibitor of Pin1.

20. A Pin1 polypeptide in the crystallized form having a substitution, insertion or deletion of one or more amino acids of the amino acid sequence set forth in SEQ ID NO:1, wherein the active site of the Pin1 polypeptide is accessible to solvent and available for interaction with an inhibitor in a crystallized form.

21. The crystallized Pin1 polypeptide of claim 20 wherein the substitution, insertion or deletion of one or more amino acids is within the WW-domain of the Pin-i polypeptide.

22. The crystallized Pin1 polypeptide of claim 21 having one amino acid substitution.

23. The crystallized Pin1 polypeptide of claim 21, having an amino acid substitution at position 14 of the amino acid sequence set forth in SEQ ID NO:1.

24. The crystallized Pin1 polypeptide of claim 23, wherein the amino acid substitution at position 14 is a nonpolar amino acid.

25. The crystallized Pin1 polypeptide of claim 24, wherein the nonpolar amino acid at position 14 is alanine (SEQ ID NO:2).

26. The crystallized Pin1 polypeptide of any one of claims 20-25, wherein the polypeptide crystallizes within 7 days.

27. The crystallized Pin1 polypeptide of claim 26, wherein the polypeptide crystallizes within 3 days.

28. The crystallized Pin1 polypeptide of claim 26, wherein the polypeptide crystallizes within 2 days.

29. The crystallized Pin1 polypeptide of claim 26, wherein the polypeptide crystallizes within 24 hours.

30. The crystallized Pin 1 polypeptide of any of claims 20-25, having a resolution of about 3 Å or less.

31. The crystallized Pin1 polypeptide of claim 30, having a resolution of 2 Å or less.

32. The crystallized Pin1 polypeptide of claim 25, wherein the three dimensional structure of the polypeptide has the space group P3121.

33. The crystallized Pin1 polypeptide of claim 32 defined by the atomic coordinates set forth in FIG. 1.

34. A crystallized fragment of the Pin1 polypeptide of any of claims 20-25.

35. The crystallized fragment of claim 34, wherein the fragment comprises the active site of the Pin1 polypeptide.

36. The crystallized Pin1 polypeptide of claim 20, further comprising a Pin1 polypeptide inhibitor in the active site.

37. The Pin1 polypeptide inhibitor of claim 36, wherein the inhibitor is a small molecule.

38. A method for designing an inhibitor of a second peptidyl/prolyl isomerase comprising the steps of: (a) providing a first peptidyl/prolyl isomerase having a known three-dimensional structure; (b) identifying amino acids in the active site of said first peptidyl/prolyl isomerase that form close contacts with a compound know to bind to said active site; (c) employing protein alignment means to identify in a second peptidyl/prolyl isomerase one or more amino acids that align with, but differ in identity from, said close contact amino acids in said first peptidyl/prolyl isomerase; (d) altering an amino acid in the active site of said second peptidyl/prolyl isomerase identified in step (c) to produce a mutant second peptidyl/prolyl isomerase; (e) determining that said compound binds with at least 10-fold greater affinity to said mutant second peptidyl/prolyl isomerase than to said second peptidyl/prolyl isomerase, and (f) using molecular modeling means to determine how to modify said compound to design an inhibitor of said second peptidyl/prolyl isomerase, wherein said inhibitor binds to said second peptidyl/prolyl isomerase with at least 10-fold greater affinity than said compound binds to said peptidyl/prolyl isomerase, respectively.

39. The method according to claim 38, wherein said first peptidyl/prolyl isomerase is Pin1 having the amino acid sequence set forth in SEQ ID NO:1.

40. The method according to claim 38, wherein said second peptidyl/prolyl isomerase is selected from the group consisting of hCyP-A, hCyP-B, hCyP-C, NKCA, hFKBP-12, hFKBP-13, Par14 and hFKBP-25.