Claims
- 1. A method for detecting abnormal cells comprising:
obtaining a sample; contacting the sample with a multivalent metal oxide; and detecting binding of the multivalent metal oxide to an abnormal cell or a protein associated with an abnormal cell.
- 2. The method of claim 1, wherein the sample is selected from the group consisting of muscle tissue, cervical tissue, skin tissue, spinal tissue and liver tissue.
- 3. The method of claim 1, wherein the sample is selected from the group consisting of blood cells, fat cells, cervical cells, cheek cells, throat cells, mammary cells, muscle cells, skin cells, liver cells, spinal cells and bone marrow cells.
- 4. The method of claim 1, wherein the multivalent metal oxide is selected from the group consisting of Ag4O4, Bi2O4, CO3O4, Fe3O4, Mn3O4, Pr6O11 and Tb4O7.
- 5. The method of claim 4, wherein the multivalent metal oxide is Ag4O7.
- 6. The method of claim 1 wherein the protein is tNOX.
- 7. A method for detecting a microorganism in a sample comprising:
obtaining a sample; contacting the sample with a multivalent metal oxide; and detecting binding of the multivalent metal oxide to a microorganism, wherein binding occurs when a microorganism is present in the sample.
- 8. The method of claim 7, wherein the sample is a bodily fluid.
- 9. The method of claim 8, wherein the bodily fluid is selected from the group consisting of sputum, lymph, blood, urine, tears, breast milk, nipple aspirate fluid, seminal fluid, vaginal secretions, feces, cerebrospinal fluid, peritoneal fluid, pleural fluid, pus and ascites.
- 10. The method of claim 7, wherein the multivalent metal oxide is selected from the group consisting of Ag4O4, Bi2O4, CO3O4, Fe3O4, Mn3O4, Pr6O11 and Tb4O7.
- 11. The method of claim 10, wherein the multivalent metal oxide is Ag4O4.
- 12. The method of claim 7, wherein the microorganism is selected from the group consisting of viruses, bacteria, fungi and parasites.
- 13. A method for diagnosing a disorder associated with aberrant cellular proliferation in a subject comprising:
obtaining a sample from the subject; contacting the sample with a multivalent metal oxide; detecting binding of the multivalent metal oxide to the sample; and diagnosing a disorder associated with aberrant cellular proliferation if binding occurs.
- 14. The method of claim 13, wherein the disorder is cancer.
- 15. The method of claim 13, wherein the sample is selected from the group consisting of muscle tissue, cervical tissue, skin tissue, spinal tissue, liver tissue.
- 16. The method of claim 13, wherein the sample is selected from the group consisting of blood cells, fat cells, cervical cells, cheek cells, throat cells, mammary cells, muscle cells, skin cells, liver cells, spinal cells and bone marrow cells.
- 17. The method of claim 13, wherein the multivalent metal oxide is selected from the group consisting of Ag4O4, Bi2O4, CO3O4, Fe3O4, Mn3O4, Pr6O11 and Tb4O7.
- 18. The method of claim 13, wherein the multivalent metal oxide is Ag4O4.
- 19. The method of claim 17, wherein the subject is a mammal.
- 20. The method of claim 19, wherein the mammal is a human.
- 21. A method for diagnosing a disorder associated with infection by a microorganism in a subject comprising:
obtaining a sample from the subject; contacting the sample with a multivalent metal oxide; detecting binding of the multivalent metal oxide to the sample; and diagnosing a disorder associated with infection by a microorganism if binding occurs.
- 22. The method of claim 21, wherein the disorder is caused by a microorganism selected from the group consisting of viruses, bacteria, fungi and parasites.
- 23. The method of claim 21, wherein the sample is a bodily fluid.
- 24. The method of claim 23, wherein the bodily fluid is selected from the group consisting of sputum, lymph, blood, urine, tears, breast milk, nipple aspirate fluid, seminal fluid, vaginal secretions, feces, cerebrospinal fluid, peritoneal fluid, pleural fluid, pus and ascites.
- 25. The method of claim 21, wherein the multivalent metal oxide is selected from the group consisting of Ag4O4, Bi2O4, CO3O4, Fe3O4, Mn3O4, Pr6O11 and Tb4O7.
- 26. The method of claim 24, wherein the multivalent metal oxide is Ag4O4.
- 27. The method of claim 21, wherein the subject is a mammal human.
- 28. The method of claim 27, wherein the mammal is a human.
- 29. A kit for detecting or monitoring aberrant cellular proliferation comprising a multivalent metal oxide and instructions for use.
- 30. A kit for detecting or monitoring a microorganism comprising a multivalent metal oxide and instructions for use.
- 31. A kit for diagnosing or monitoring a disorder associated with aberrant cellular proliferation comprising a multivalent metal oxide and instructions for use.
- 32. A kit for diagnosing or monitoring a disorder associated with infection by a microorganism comprising a multivalent metal oxide and instructions for use.
RELATED APPLICATIONS
[0001] This application claims priority to PCT/US03/13033 designating the United States, filed on Apr. 28, 2003, hereby incorporated by reference in its entirety for all purposes.
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
PCT/US03/13033 |
Apr 2003 |
US |
Child |
10833490 |
Apr 2004 |
US |