METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL

Abstract
The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
Description
FIELD OF INVENTION

The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.


BACKGROUND OF THE INVENTION

Follicular neogenesis is defined as the generation of new hair follicles (HF) after birth. Humans are born with a full complement of HF, which can change in size and growth characteristics as in early baldness or can ultimately degenerate and disappear as in late stages of baldness or in permanent scarring (cicatricial) alopecias. Therefore, the generation of new HF is desirable in the treatment of common baldness as well as less common hair loss conditions, such as discoid lupus erythematosis, congenital hypotrichosis, lichen planopilaris and other scarring alopecias.


SUMMARY OF THE INVENTION

The present invention provides methods of treating baldness in a subject and generating new hair follicles (HF), comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.


In one embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.


In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.


In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region.


In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject.


In another embodiment, the present invention provides a method for increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject.


In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an AGA in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.





BRIEF DESCRIPTION OF THE FIGURES


FIG. 1: Epidermal abrasion results in de novo hair follicle (HF) formation. HF at progressive stages of development are depicted in the left, center, and right panels. The arrow in the left panel indicates a hair germ. The dark stained cells are progeny of HF stem cells in the bulge.



FIG. 2: BrdU labeling of HF following epidermal abrasion. HF at progressive stages of development are depicted in the left, center, and right panels.



FIG. 3. The wound site did not contain HF immediately after re-epithelialization. Top view (left panel) and tissue section (right panel) of the site 10 days after wound induction.



FIG. 4. Appearance of hair germs 12 days after wound induction. Arrow indicates hair germ.



FIG. 5. Epidermal Disruption-Induced HF neogenesis (EDIHN)-induced hair germs express K17. Two different hair germs are depicted in the left and right panels.



FIG. 6. EDIHN-induced hair germs contain dermal papilla (DP) cells, as evidenced by alkaline phosphatase (AP) staining. Arrows indicate DP cells. Left panel: hair germs. Right panel: HF at a further developmental stage.



FIG. 7. Histological comparison between EDIHN-induced and embryonic HF. Top left, second from left, third from left, and right panels: Progressive stages of EDIHN-induced HF development. Bottom left, center, and right panels: Progressive stages of and embryonic HF development.



FIG. 8. Induction of several markers of embryonic HF development, Lef1 (left panel), wingless/int (Wnt) 10b (center panel), and sonic hedgehog (Shh; right panel), by EDIHN. HF structures are indicated by arrowheads.



FIG. 9. Proliferative activity during EDIHN, as evidenced by BrdU pulse-labeling. Progressive stages of HF development are depicted in the left, center, and right panels.



FIG. 10. Induction of HF markers S100A3 (left panel; tissue section parallel to HF axis) and S100A6 (right panel; cross-sectional view of follicle) by EDIHN.



FIG. 11. New hair growth 25 days (left panel) and 45 days (right panel) after wound induction.



FIG. 12. Schematic of whole-mount EDIHN assay.



FIG. 13. Repopulation of stem cells in the bulge of EDIHN-induced HF, as evidenced by retention of BrdU label following a chase period. Left panel: lower magnification: 50×. Right panel: higher magnification: 400×.



FIGS. 14A-14B. FIG. 14A. Stem cells in EDIHN-induced HF express K15. Left top panel: Top view of wound site. Bottom, far left panel: epidermis whole mount; bottom, second from left panel: same as panel but viewed under white light; right panel: tissue sections. FIG. 14B. Neogenesis HF proceed to next hair cycle.



FIG. 15. Schematic of creation of new HF by EDIHN.



FIG. 16. No new HF are evident 11 days after wound induction in 21-day-old mice. Top panel: macroscopic examination; bottom left panel: AP staining of the dermis; bottom right panel: K17 staining of the epidermis.



FIG. 17. 14 days after wound induction, new HF have begun to form as evidenced by AP staining of the dermis (left panel) and K17 staining of the epidermis (right panel). Main panels: 10× magnification. Inserts: 80× magnification.



FIG. 18. 17 days after wound induction, new HF are more developed. Left panel: AP staining of the dermis; right panel: K17 staining of the epidermis. Main panels: 10× magnification. Inserts: 80× magnification.



FIG. 19. Wounds closed similar in mice subjected to depilation, then wounding (left 3 mice in each panel) vs. wounding alone (right 4 mice in each panel). Left panel: immediately following wounding. Right panel: 10 days following wounding.



FIGS. 20A-20B. Anagen induction by depilation prior to wounding enhances the efficiency of EDIHN. FIG. 20A. Top panel: lower left panel AP staining of the dermis; lower right panel: K17 staining of the epidermis. FIG. 20B. Graphical representation of enhancement of EDIHN by depilation.



FIGS. 21A-21B. FIG. 21A. EDIHN in human skin grafted to immunodeficient (scid) mice, seven days after induction of an excisional wound. Arrows indicate new HF. FIG. 21B.





Dermal abrasion of human skin grafts results in EDIHN. Human adult skin (W) was grafted onto mice, abraded, and examined seven days later, by staining for S100A6 (first, second, and fourth rows) or S100A4 (third row). Hair germs (HG) and dermal papilla (DP) are indicated. Human fetal skin (F) with normal developing hair follicles is shown for comparison. Mouse skin 17 d post wounding was included as a control (top left panel).



FIGS. 22A-22C. Transcripts up-regulated at least 2-fold in activated HF cells, as assessed by dChip analysis. (FIG. 22A). Mean values and standard errors of the up-regulated transcripts in non-activated (“bs-line”) and activated (“expt”) samples and fold-changes and differences between non-activated and activated values are depicted. (FIG. 22B). Raw data for up-regulated transcripts in non-activated and activated cells. “Ctrl” denotes non-activated and “High-dep” denotes activated cells. (FIG. 22C). Additional information about up-regulated transcripts.



FIGS. 23A-23B. Pigmented hair follicle neogenesis observed in the skin of Dkk1-expressing mice following EDIHN FIG. 23A. 3.2× magnification. FIG. 23B. 8× magnification.



FIG. 24. Control mice lacked pigmented HF.



FIGS. 25A-25D. EGF inhibits HF formation by EDIHN. FIG. 25A. K17 staining of wounded skin of representative mouse treated with EGF. Magnification is 4×. FIG. 25B. High magnification view (10×) of skin depicted in (FIG. 25A). FIG. 25C. K17 staining of wounded skin of representative control mouse that received no EGF after wounding. Magnification is 4×. FIG. 25D. Higher magnification view (10×) of skin depicted in (FIG. 25D).



FIGS. 26A-26B. Administration of an EGF receptor inhibitor (AG1478) leads to generation of more and larger HF compared with controls. FIG. 26A. Top: skin of 2 control mice. Outer dashed line indicates the extent of the wounded area after contraction and healing; inner dashed line indicates the area of neogenesis. Bottom: skin of 2 treated mice, in which the wounded area and area of neogenesis largely coincide, with the exception of a small area on the left side of the encircled area in each panel. FIG. 26B. Large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing DP areas. Scale Bars: 200 μm.



FIGS. 27A-27C. FIG. 27A. Increased hair follicle formation in K14-Wnt7a mice. Left panel: Wnt7a transgenic mice. Right panel: control (wild-type) mice. FIG. 27B. Quantiation of experiment with 4 week old mice. FIG. 27C. Quantiation of experiment with 3 week old mice.


DETAILED DESCRIPTION OF THE INVENTION

The present invention provides methods of treating baldness in a subject and generating new HF, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.


In one embodiment, the present invention provides a method for generating a hair follicle (HF) in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.


In another embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.


In another embodiment, the present invention provides a method for generating a new HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a new HF in a scalp, eyebrow, or scarred region of a subject.


In another embodiment, the present invention provides a method for increasing the number of HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing the number of HF in a scalp, eyebrow, or scarred region of a subject.


In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor.


In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor.


In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the compound or factor.


In another embodiment, the present invention provides a method for increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, the factor is an inhibitor of an EGF protein or an EGFR. In another embodiment, the factor is a Hedgehog protein, a nucleotide encoding same or an activator of same. In another embodiment, the factor is an androgen antagonist. In another embodiment, the factor is any other compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.


The precursor cell of methods and compositions of the present invention, is, in another embodiment, a HF stem cell. In another embodiment, the precursor cell is an epidermal cell. In another embodiment, the precursor cell is a dermal papilla cell. In another embodiment, the precursor cell is a connective tissue sheath cell. In another embodiment, the precursor cell is any other type of cell known in the art that is capable of differentiation into a hair follicle cell. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a precursor cell that is capable of differentiation into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.


In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an AGA in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a precursor cell that is capable of differentiation into a hair follicle cell, thereby treating an AGA in a scalp.


In another embodiment, the inductive cell is a mesenchymal cell. In another embodiment, the inductive cell is any other type of inductive cell enumerated herein. In another embodiment, the inductive cell is any other type of inductive cell known in the art. Each possibility represents a separate embodiment of the present invention.


“Contacting” as used herein refers, in another embodiment, to bringing the scalp, eyebrow, etc, into to contact with the compound, factor, cell, etc. In another embodiment, the term refers to embedding the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, the term refers to injecting the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, term refers to any other type of contacting known in the art. Each possibility represents a separate embodiment of the present invention.


“Promotes a differentiation” refers, in another embodiment, to the act of increasing the percentage of cells that will differentiate as indicated. In another embodiment, the term refers to increasing the number of cells per unit area of skin that will differentiate. In another embodiment, the promoter of differentiation is active in the milieu of the skin. Each possibility represents a separate embodiment of the present invention.


“Uncommitted epidermal cell” refers, in another embodiment, to an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is a bulge-derived cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF cell.


The “HF cell” that results from the differentiation is, in another embodiment, an HF stem cell. In another embodiment, the HF cell is a dermal papilla cell. In another embodiment, the HF cell is a bulb cell. In another embodiment, the HF cell is a matrix cell. In another embodiment, the HF cell is a hair shaft cell. In another embodiment, the HF cell is an inner root sheath cell. In another embodiment, the HF cell is an outer root sheath cell. In another embodiment, the HF cell is a melanocyte stem cell. In another embodiment, the HF cell is a melanocyte. Each type of uncommitted epidermal cell and HF cell represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is administered in a solution. In another embodiment, the compound or factor is administered in a cream. In another embodiment, the compound or factor is administered in an ointment. In another embodiment, the compound or factor is administered in a slow release formulation. In another embodiment, the compound or factor is administered in a liposome encapsulated formulation. In another embodiment, the compound or factor is directly injected. In another embodiment, the compound or factor is administered by any other method known in the art. Each possibility represents a separate embodiment of the present invention.


The compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is, in another embodiment, an inhibitor of an Epidermal Growth Factor (EGF). In another embodiment, the compound or factor is an inhibitor of an EGF receptor. Each possibility represents a separate embodiment of the present invention.


As provided herein (Example 11), activating one or more pathways in which EGF is involved (by injection of EGF) blocks the formation of HF. Thus, antagonizing the pathway increases HF formation, as demonstrated in Example 12.


In another embodiment, the inhibitor of an EGF or an EGF receptor is panitumumab. In another embodiment, the inhibitor is AG1478. In another embodiment, the inhibitor is nimotuzumab. In another embodiment, the inhibitor is an antibody that binds EGF or EGFR. In another embodiment, the inhibitor is HuMax-EGFR® (Genmab, Copenhagen, Denmark). In another embodiment, the inhibitor is cetuximab. In another embodiment, the inhibitor is IMC 11F8. In another embodiment, the inhibitor is matuzumab. In another embodiment, the inhibitor is SC 100. In another embodiment, the inhibitor is ALT 110. In another embodiment, the inhibitor is PX 1032. In another embodiment, the inhibitor is BMS 599626. In another embodiment, the inhibitor is MDX 214. In another embodiment, the inhibitor is PX 1041. In another embodiment, the inhibitor is any other inhibitor of an EGF or an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an inhibitor of a tyrosine kinase activity of an EGF receptor. In another embodiment, the inhibitor is gefitinib. In another embodiment, the inhibitor is erlotinib. In another embodiment, the inhibitor is canertinib. In another embodiment, the inhibitor is leflunomide. In another embodiment, the inhibitor is A77 1726. In another embodiment, the inhibitor is pelitinib. In another embodiment, the inhibitor is ZD 1839. In another embodiment, the inhibitor is CL 387785. In another embodiment, the inhibitor is EKI 785. In another embodiment, the inhibitor is vandetanib. In another embodiment, the inhibitor is any other inhibitor of a tyrosine kinase activity of an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the EGF or EGFR antagonist is a carboxypeptidase inhibitor from potato (PCI) protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a sprouty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an Argos protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a lefty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an antibody that recognizes EGF or EGFR, or a fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is small molecule inhibitor that binds and reduces the activity of EGF or EGFR. In another embodiment, the EGF or EGFR antagonist is CRM197. In another embodiment, the EGF or EGFR antagonist is IMC-C225 (ImClone Systems, New York, N.Y.). In another embodiment, the EGF or EGFR antagonist is any other antagonist of EGF or EGFR known in the art. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor.


In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor.


In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the inhibitor of an EGF protein or an EGF receptor.


In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a β-catenin protein. In another embodiment, the compound or factor is a nucleotide that encodes a β-catenin protein. In another embodiment, the compound or factor is an activator of a β-catenin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the β-catenin protein. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the β-catenin protein, nucleotide, compound or factor.


In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the β-catenin protein, nucleotide, compound or factor.


In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the β-catenin protein, nucleotide, compound or factor.


In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a fibroblast growth factor (FGF) protein. In another embodiment, the compound or factor is a nucleotide that encodes an FGF protein. In another embodiment, the compound or factor is an FGF receptor. In another embodiment, the compound or factor is a nucleotide that encodes an FGF receptor. In another embodiment, the compound or factor is an activator of an FGF protein. In another embodiment, the compound or factor is an activator of FGF receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the FGF protein or FGF receptor. In another embodiment, the protein that is inhibited is an FGF binding protein. In another embodiment, the protein that is inhibited is FGF-bp1. Each possibility represents a separate embodiment of the present invention.


Is provided herein, FGF and its receptor are upregulated, under the conditions utilized herein, upon HF stem cell differentiation (Example 9). Moreover, FGF-bp1 is downregulated, under the conditions utilized herein, upon HF stem cell differentiation. Thus, FGF and its receptor promote differentiation of uncommitted epidermal cells into HF cells.


In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an ectodysplasin protein (referred to, in another embodiment, as “eda”; in another embodiment, as “ectodermodysplasin protein.”) In another embodiment, the ectodysplasin protein is Eda-A1. In another embodiment, the compound or factor is an ectodysplasin receptor (referred to, in another embodiment, as “edar”). In another embodiment, the compound or factor is an activator of an ectodysplasin protein. In another embodiment, the compound or factor is an activator of an ectodysplasin receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the ectodysplasin protein or ectodysplasin receptor. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the eda protein of methods and compositions of the present invention has the sequence:


MGYPEVERRELLPAAAPRERGSQGCGCGGAPARAGEGNSCLLFLGFFGLSLALHLLTLCC YLELRSELRRERGAESRLGGSGTPGTSGTLSSLGGLDPDSPITSHLGQPSPKQQPLEPGEAA LHSDSQDGHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGP PGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGT RENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFI YSQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVK MVHADISINMSKHTTFFGAIRLGEAPAS (GenBank Accession No: NM_001399; SEQ ID No: 274). In another embodiment, the eda protein has a sequence selected from the sequences set forth in GenBank entries NM_001005609, NM_001005610, NM_001005611, NM_001005612, NM_001005613, NM_001005614, NM_001005615, AF040628, AF061194, AF061193, AF061192, AF061191, AF061190, AF061189, and AF060999. In another embodiment, the eda protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an Eda protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the edar protein of methods and compositions of the present invention has the sequence:









MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPC





GPGEEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRAT





VLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVG





ATSGASANFPGTSGSSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAI





AIVLIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKKEAPDNVVMFS





EKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPEL





CLLSLVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPF





DCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDR





ISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASQPHAAS





(GenBank Accession No: BC093872; SEQ ID No: 275).







In another embodiment, the edar protein has a sequence selected from the sequences set forth in GenBank entries BC093870; BC034919; NM_021783; NM_022336; AY152724; AF298812; AH008077; AF130996; AF130988. In another embodiment, the edar protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an Edar protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Noggin protein. In another embodiment, the compound or factor is a nucleotide encoding a Noggin protein. In another embodiment, the compound or factor is an activator of a Noggin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the Noggin protein. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the Noggin protein of methods and compositions of the present invention has the sequence:


MERCPSLGVTLYALVVVLGLRATPAGGQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLN ETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGL EFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKR SCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC (GenBank Accession No: NM_005450; SEQ ID No: 276). In another embodiment, the Noggin protein has a sequence selected from the sequences set forth in GenBank entries BC034027 and U31202. In another embodiment, the Noggin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Noggin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a Hedgehog protein. In another embodiment, the compound or factor is an activator of a Hedgehog protein. In another embodiment, the compound or factor is a sonic Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a sonic Hedgehog protein. In another embodiment, the compound or factor is an activator of a sonic Hedgehog protein. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the Hedgehog protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. NM_000193. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries L38518 and NP_000184. In another embodiment, the Hedgehog protein has any other Hedgehog sequence known in the art. In another embodiment, the Hedgehog protein has any other sonic Hedgehog sequence known in the art. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Transforming Growth Factor (TGF)-beta1 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta1 protein. In another embodiment, the compound or factor is an activator of a TGF-beta1 protein. In another embodiment, the compound or factor is a TGF-beta3 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta3 protein. In another embodiment, the compound or factor is an activator of a TGF-beta3 protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta1 protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta3 protein. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the TGF-beta1 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. BC000125. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries BC001180, BC022242, and NM_000660. In another embodiment, the TGF-beta1 protein has any other TGF-beta1 sequence known in the art. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the TGF-beta3 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. J03241. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries NM_003239, BC018503, BT007287 and X14149. In another embodiment, the TGF-beta3 protein has any other TGF-beta3 sequence known in the art. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell acts directly on the uncommitted epidermal cell. In another embodiment, the compound or factor acts on the uncommitted epidermal cell via a mesenchymal cell. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the mesenchymal cell is a dermal condensate cell. In another embodiment, the mesenchymal cell is a DP cell. In another embodiment, the mesenchymal cell is another cell type or differentiation stage in the dermal condensate-DP lineage. In another embodiment, the mesenchymal cell is any other type of mesenchymal cell known in the art. Each possibility represents a separate embodiment of the present invention.


The EGFR of methods and compositions of the present invention has, in another embodiment, the sequence:


MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCE VVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAG CTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRN YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKH FKNCTSIS GDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFE NLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTS GQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEG EPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNT LVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIG LFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVY KGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLI TQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT PQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWE LMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFS K MARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTS RTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYIN QSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSP AHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA (GenBank Accession No: NM_005228; SEQ ID No: 277). In another embodiment, the EGFR has a sequence selected from the sequences set forth in GenBank entries NM_201282, NM_201283, NM_201284, BC094761, AF288738, AY588246, AY573061, X17054, AF125253, U48722, K03193, and AY698024. In another embodiment, the EGFR is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an EGFR is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.


The EGF of methods and compositions of the present invention has, in another embodiment, the sequence:


MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGT NYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAIN WINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRAD LDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHN LFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDD TWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCT LGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVL ERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANS QDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERL IEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKR LFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGS KRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVV VHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGG EVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDA TCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDID ECQLGVHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSE CPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKV IVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSC PQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSS DKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ (GenBank Accession No: NM_001963; SEQ ID No: 278). In another embodiment, the EGF has a sequence selected from the sequences set forth in GenBank entries BC093731, AY548762, and X04571. In another embodiment, the EGF is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an EGF is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.


The beta-catenin protein of methods and compositions of the present invention has, in another embodiment, the sequence:


MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDT SQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHP TNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQL S KKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPA LVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTD CLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAG GMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLV RAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQL LYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMS EDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGY GQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL (GenBank Accession No: NM_001904; SEQ ID No: 279). In another embodiment, the beta-catenin protein has a sequence selected from the sequences set forth in GenBank entries BC058926, X87838, AF130085, AB062292, Z19054, and NP_001895. In another embodiment, the beta-catenin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a beta-catenin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.


The Wnt protein of methods and compositions of the present invention has, in another embodiment, the sequence:


MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIG EGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAAC TQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNL HNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVR ASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASG CDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK (GenBank Accession No: BC008811; SEQ ID No: 280). In another embodiment, the Wnt protein has a sequence selected from the sequences set forth in GenBank entries NM_004625, D83175, U53476, and NP_004616. In another embodiment, the Wnt protein is a Wnt7 protein. In another embodiment, the Wnt protein is a Wnt7a protein. In another embodiment, the Wnt protein is Wnt1 protein. In another embodiment, the Wnt protein is a Wnt3 protein. In another embodiment, the Wnt protein is a Wnt3a protein. In another embodiment, the Wnt protein is a Wnt10 protein. In another embodiment, the Wnt protein is a Wnt10a protein. In another embodiment, the Wnt protein is a Wnt10b protein. In another embodiment, the Wnt protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Wnt protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7 protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7a protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by a ribonucleic acid (RNA) molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. Each possibility represents a separate embodiment of the present invention.


As provided herein, the transcripts depicted in Table 3 (Example 8; SEQ ID No: 1-232), the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, under the conditions utilized herein, anagen can be induced by activation of these transcripts, proteins, and pathways. Activation of the transcripts, proteins, and pathways depicted in Table 3 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject.


In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-257. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. Each possibility represents a separate embodiment of the present invention.


As provided herein, the transcripts depicted in Table 4 (Example 9; SEQ ID No: 233-257), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, under the conditions utilized herein, to induction of epidermal cells to differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject.


In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that decreases an activity of a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 258-273. In another embodiment, the compound or factor decreases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 258-273. Each possibility represents a separate embodiment of the present invention.


As demonstrated by findings of the present invention, the transcripts depicted in Table 5 (Example 9; SEQ ID No: 258-273), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, under the conditions utilized herein, to preventing induction of epidermal cells to differentiate into HF stem cells. Inhibition of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN. In another embodiment, inhibition of these transcripts, proteins, and pathways represents a method for induction of hair growth in a subject.


In one embodiment, the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-273 or the nucleic acid encoding same is administered before the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232 or the nucleic acid encoding same. In another embodiment, the two compounds are administered simultaneously. Each possibility represents a separate embodiment of the present invention.


In one embodiment, a protein encoded by an RNA sequence selected from SEQ ID No: 1-273, or a compound that modulates the protein, is administered before other proteins encoded by same or compounds that modulate them, in order to further enhance their effect in generating an HF or stimulating hair growth. In another embodiment, the wnt pathway is stimulated before the hedgehog pathway. In another embodiment, the two pathways are stimulated in an overlapping fashion. In another embodiment, the two pathways are stimulated simultaneously. Each possibility represents a separate embodiment of the present invention.


In another embodiment, activating or decreasing expression of an RNA transcript in methods of the present invention occurs via a transcription mechanism (e.g. activation of expression of the RNA). In another embodiment, activating or decreasing expression of the RNA transcript occurs via a translational mechanism. In another embodiment, activating or decreasing expression of the RNA transcript occurs via a post-translational mechanism. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the nucleic acid molecule utilized in methods of the present invention is a deoxyribonucleic acid (DNA) molecule that encodes an RNA molecule having a sequence selected from the sequences set forth in the present invention.


In one embodiment, an RNA molecule of the present invention encodes a protein that plays a role in HF regeneration. In another embodiment, the RNA molecule is itself catalytically active, e.g., a ribozyme, etc. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that promotes placodal cell fate. As provided herein, factors that promote placodal cell fate enhance EDIHN, as exemplified in the Examples herein. In another embodiment, the compound or factor acts at the placode stage of HF development.


In another embodiment, the compound or factor inhibits a biological factor that inhibits a differentiation of an uncommitted epithelial cell into an HF cell.


In another embodiment of methods and compositions of the present invention, a composition comprising one of the above compounds or factors is administered. Each of the above types of compounds, factors, and compositions represents a separate embodiment of the present invention.


In one embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.


In one embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby treating baldness in a scalp, eyebrow, or scarred region of a subject.


In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for an HF in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the minoxidil.


In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the minoxidil.


In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject.


In another embodiment, the present invention provides a method for hair removal from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing hair from a skin or scalp of a subject. In another embodiment, the epidermal disruption is light dermabrasion. In another embodiment, the epidermal disruption is a non-scarring method. In another embodiment, administration of the EGF protein, EGF receptor, nucleotide, compound, or factor suppresses HF formation. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within several days of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within about 1 day of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered according to any of the timing embodiments enumerated herein for Dkk1 protein. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a use of either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, for the preparation of a pharmaceutical composition for use in a method for removal of an HF from a skin or scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the EGF protein, EGF receptor, nucleotide, compound, or factor.


In another embodiment, a composition or method of the present invention is utilized on human skin. In another embodiment, the composition or method is utilized on an area of unwanted hair growth. In another embodiment, the area is the face. In another embodiment, the area is the bikini area. In another embodiment, the area is the legs. In another embodiment, the area is the arms. In another embodiment, the area is the chest.


An “inhibitor” utilized in methods and compositions of the present invention is, in another embodiment, an antibody that binds the protein or biological factor that is the target of the inhibitor. In another embodiment, the inhibitor is a pharmacologic inhibitor. In another embodiment, the inhibitor is any other type of inhibitor known in the art. Each possibility represents a separate embodiment of the present invention.


The step of disrupting the epidermis in methods of the present invention is performed, in another embodiment, by abrading the scalp, eyebrow, or scarred region. In another embodiment, the term “abrading” refers to an act of creating an abrasion. In another embodiment, “abrading” refers to rubbing. In another embodiment, “abrading” refers to wearing away by friction. As provided herein (Example 1), epidermal abrasion causes, under the conditions utilized herein, de novo HF neo-genesis. In another embodiment, the epidermal layer is disrupted.


In one embodiment, “abrasion” has the same meaning as “abrading.” In another embodiment, “abrasion” refers to an area of the scalp or skin from which the epidermis is removed. In another embodiment, “abrasion” refers to an area of the scalp or skin from which the epidermis and dermis are removed. Each definition of “abrading” and “abrasion” represents a separate embodiment of the present invention.


As provided herein, under the conditions utilized, epidermal disruption by a method of the present invention converts the skin back, in another embodiment, to an embryonic-like state, in which the follicle regenerates. In another embodiment, a subsequent window of opportunity is created, during which the number and size of new HF in the skin can be manipulated. In another embodiment, the administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell during this window causes regeneration of larger and more numerous HF. The morphology of HF in abraded skin is similar to that of embryonic HF (Example 1-2 and subsequent Examples), and the markers expressed are similar as well.


In another embodiment, the present invention provides a method of stimulating hair growth in a scalp, eyebrow, or scarred region of a subject, comprising performing a method of present invention, thereby stimulating hair growth in a scalp, eyebrow, or scarred region of a subject. As demonstrated in Example 3, EDIHN-induced HF are capable of generating hairs. Thus, methods of the present invention can be used to stimulate hair growth.


“EDIHN,” in another embodiment, refers to HF neogenesis induced by disruption of the epithelial layer. In another embodiment, the term refers to HF neogenesis induced by abrasion. In another embodiment, the term refers to HF neogenesis induced by wounding. In another embodiment, the term refers to HF neogenesis induced by disruption of the epithelial layer, followed by administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a method of testing an ability of a compound to modulate HF generation in vivo, comprising (a) disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; (b) measuring a first HF generation in the first scalp, eyebrow, or scarred region; (c) disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, wherein the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of the first subject or a second subject, whereby the second scalp, eyebrow, or scarred region has not been contacted with the compound; (d) measuring a second HF generation in the second scalp, eyebrow, or scarred region; and (e) comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound modulates an HF generation in vivo (Examples).


In another embodiment, the present invention provides a method of testing an ability of a compound to stimulate hair growth in vivo, comprising disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; measuring a first HF generation in the first scalp, eyebrow, or scarred region; disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, whereby the second scalp, eyebrow, or scarred region has not been contacted with the compound; measuring a second HF generation in the second scalp, eyebrow, or scarred region; and comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound stimulates a hair growth in vivo.


In one embodiment, the methods of the present invention of testing a compound are repeated using a plurality of subjects, until a statistically significant sample has been tested.


In another embodiment of methods for testing compounds of the present invention, the first scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a first subject. In another embodiment, the subject is a subject in need of generation of a new HF. The second scalp, eyebrow, or scarred region, in another embodiment, is a scalp, eyebrow, or scarred region of the first subject. In another embodiment, the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a second subject. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the excisional wounds of methods of the present invention are created using a surgical tool. In one embodiment, the surgical tool is a dermal biopsy punch (Example 2). In another embodiment, the excisional wounds are induced by freezing or cryoinjury. The use of freezing or cryoinjury is well known in the art, and is used, for example by dermatologists to injure skin. In one embodiment, the freezing or cryoinjury results in a blister. In another embodiment, the blister is used as a “chamber” to introduce drugs and or cells into the reepithelialized area. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the excisional wounds of methods of the present invention are not surgically closed. In another embodiment, the excisional wounds are not contacted with a bandage or dressing before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are not contacted with an ointment before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are allowed to heal by secondary intention. Each possibility represents a separate embodiment of the present invention.


The subject of methods of the present invention, is, in another embodiment, a human. As provided herein (Example 7) human skin responds to EDIHN in the same manner as mouse skin. In another embodiment, the subject is a male. In another embodiment, the subject is a female. In another embodiment, the subject is any other type of subject known in the art. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the subject is an adult. In one embodiment, “adult” refers to an age greater than about 18 years. In another embodiment, “adult” refers to an age greater than about 20 years. In another embodiment, “adult” refers to an age greater than about 25 years. In another embodiment, “adult” refers to an age greater than about 30 years. In another embodiment, “adult” refers to an age greater than about 35 years. In another embodiment, “adult” refers to an age greater than about 40 years. In another embodiment, “adult” refers to an age greater than about 45 years.


In another embodiment, the subject is elderly. In one embodiment, “elderly” refers to an age greater than about 45 years. In another embodiment, “elderly” refers to an age greater than about 50 years. In another embodiment, “elderly” refers to an age greater than about 55 years. In another embodiment, “elderly” refers to an age greater than about 60 years. In another embodiment, “elderly” refers to an age greater than about 65 years. In another embodiment, “elderly” refers to an age greater than about 70 years.


In another embodiment, the first subject, or, where applicable, both the first subject and the second subject, is a laboratory animal. In another embodiment, the subject(s) is/are mice. In another embodiment, the subject(s) is/are rats. In another embodiment, the subject(s) is/are gerbils. In another embodiment, the subject(s) is/are hamsters. In another embodiment, the subject(s) is/are guinea pigs. In another embodiment, the subject(s) is/are rabbits. In another embodiment, the subject(s) is/are pigs. In another embodiment, the subject(s) is/are dogs. In another embodiment, the subject(s) is/are cats. In another embodiment, the subject(s) is/are primates. In another embodiment, the subject(s) is/are any other laboratory animal known in the art. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the subject(s) has a disease or disorder comprising balding. In another embodiment, the subject(s) does not have a disease or disorder comprising balding. In another embodiment, the disease or disorder is androgenetic alopecia (AGA). In another embodiment, the disease or disorder is male pattern baldness. In another embodiment, the disease or disorder is female pattern baldness. In another embodiment, the disease or disorder is a discoid lupus erythematosis. In another embodiment, the disease or disorder is a congenital hypotrichosis. In another embodiment, the disease or disorder is a lichen planopilaris. In another embodiment, the disease or disorder is a scarring alopecia. In another embodiment, the disease or disorder is any other disease or disorder comprising balding known in the art.


In another embodiment, the scalp, eyebrow, or scarred region(s) has a majority of HF in the telogen stage of the hair cycle. The findings of Examples 5-6 show that (a) EDIHN can restore hair growth to the scalp, eyebrow, or scarred region at the telogen stage; and (b) the efficiency of EDIHN at the telogen stage can be enhanced by depilation prior to abrasion or wound induction. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 60% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 70% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 80% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 90% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) does not have a majority of HF in the telogen stage of the hair cycle. Each possibility represents a separate embodiment of the present invention.


In another embodiment of methods and compositions of the present invention, the first step (e.g. epithelial disruption) is performed 3-12 days prior to the second step (e.g. addition of an active compound, factor, cell, etc). In another embodiment, the interval is 4-12 days. In another embodiment, the interval is 5-12 days. In another embodiment, the interval is 4-11 days. In another embodiment, the interval is 6-11 days. In another embodiment, the interval is 6-10 days. In another embodiment, the interval is 6-9 days. In another embodiment, the interval is 6-8 days. In another embodiment, the interval is 7-8 days. In another embodiment, the interval is 5-11 days. In another embodiment, the interval is 5-10 days. In another embodiment, the interval is 7-10 days. In another embodiment, the interval is about 1 week. Each possibility represents a separate embodiment of the present invention.


In another embodiment, a method of the present invention further comprises the step of suppressing an activity or expression of a Wnt protein in the scalp, eyebrow, or scarred region. As provided herein, suppressing Wnt activity induces pigmentation in HF generated by methods of the present invention. In another embodiment, the step of suppressing Wnt activity or expression is performed within about 10 days of epidermal disruption. In another embodiment, the step of suppressing Wnt activity or expression is performed prior to the second step (e.g prior to addition of a compound or factor that promotes HF cell differentiation. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a method for inducing pigmentation of a hair, comprising suppressing expression of a Wnt protein in a follicle of the hair. In another embodiment, the Wnt protein is Wnt1. In another embodiment, the Wnt protein is a Wnt7. In another embodiment, the Wnt protein is a Wnt7a. In another embodiment, the Wnt protein is a Wnt3. In another embodiment, the Wnt protein is a Wnt3a. In another embodiment, the Wnt protein is a Wnt10. In another embodiment, the Wnt protein is a Wnt10a. In another embodiment, the Wnt protein is any other Wnt protein known in the art. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a method for inducing growth of a pigmented scalp hair or eyebrow of a subject, comprising generating a hair follicle in the scalp, eyebrow, or scarred region according to a method of the present invention and suppressing expression of a Wnt protein in the hair follicle, thereby inducing a growth of a pigmented scalp hair or eyebrow of a subject.


In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of a Dkk1 protein. In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of any other Wnt inhibitor known in the art. In another embodiment, the step of suppressing expression of a Wnt protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of inducing expression of a Dkk1 protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed at the time of epidermal disruption. In another embodiment, the step of inducing expression of a Dkk1 protein is performed at the time of epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed several days before generation of the follicle. In another embodiment, the step of inducing expression of a Dkk1 protein several days before generation of the follicle. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 8 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 8 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 9 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 9 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 10 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 10 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 12 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 12 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed during the period of re-epithelialization. In another embodiment, the step of inducing expression of a Dkk1 protein is performed during the period of re-epithelialization. In another embodiment, expression of a Dkk1 protein is halted after several days. In another embodiment, halting expression of Dkk1 protein after several days induces, or enables induction of Wnt protein expression. In another embodiment, the expression of a Wnt protein is induced about 9 days after the abrating or wounding. In another embodiment, the expression of a Wnt protein is induced following the period of re-epithelialization. In another embodiment, induction of Wnt protein expression is necessary for formation of new HF. Each possibility represents a separate embodiment of the present invention.


In another embodiment, “several” refers to about 1 day. In another embodiment, “several” refers to about 2 days. In another embodiment, “several” refers to about 3 days. In another embodiment, “several” refers to about 5 days. In another embodiment, “several” refers to about 7 days. In another embodiment, “several” refers to about 10 days. In another embodiment, “several” refers to about 12 days. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the step of contacting in methods of the present invention comprises directly contacting the scalp, eyebrow, or scarred region with the compound, RNA, protein, etc. In another embodiment, the step of contacting comprises indirectly contacting the scalp, eyebrow, or scarred region via contacting another site or tissue of the subject, after which the compound, RNA, or protein is transported to the scalp, eyebrow, or scarred region by a biological process; e.g, diffusion, active transport, or circulation in a fluid such as the blood, lymph, interstitial fluid, etc. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the epidermal disruption in methods of the present invention further removes dermal tissue from the scalp, eyebrow, or scarred region. In another embodiment, the epidermal disruption does not remove dermal tissue from the scalp, eyebrow, or scarred region. Each possibility represents a separate embodiment of the present invention.


“Disrupting” an epidermis or epidermal layer refers, in another embodiment, to removing part of the epidermis or epidermal layer. In another embodiment, the term refers to disturbing the intactness of the epidermis or epidermal layer. In another embodiment, the term refers to perforating the epidermis or epidermal layer. In another embodiment, only part of the epidermal layer need be removed. In another embodiment, the entire epidermal layer is removed. In another embodiment, the term refers to abrading the epidermis or epidermal layer (Examples). In another embodiment, the term refers to wounding the epidermis or epidermal layer (Examples). Each possibility represents a separate embodiment of the present invention.


In another embodiment, the epidermal disruption is performed with a tool that comprises sandpaper. In another embodiment, the epidermal disruption is performed with a laser. In another embodiment, the laser is a Fraxel laser. In another embodiment, the laser is a CO2 laser. In another embodiment, the laser is an excimer laser. In another embodiment, the laser is any other type of laser capable of inducing trans-epithelial injury. In another embodiment, the epidermal disruption is performed with a felt wheel. In another embodiment, the epidermal disruption is performed with a surgical tool. In another embodiment, the epidermal disruption is performed with any other tool known in the art that is capable of epidermal disruption. In another embodiment, the epidermal disruption comprises use of a micro-dermabrasion device. In another embodiment, the epidermal disruption comprises a burn treatment.


In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and a disruption of an interfollicular region of said epidermis. In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and does not comprise a disruption of an interfollicular region of said epidermis. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the epidermal disruption comprises a light-based method. In another embodiment, the epidermal disruption comprises irradiation with visible light. In another embodiment, the epidermal disruption comprises irradiation with infrared light. In another embodiment, the epidermal disruption comprises irradiation with ultraviolet radiation. In another embodiment, the epidermal disruption comprises orthovoltage irradiation. In another embodiment, the epidermal disruption comprises X-ray irradiation. In another embodiment, the epidermal disruption comprises any other type of irradiation known in the art.


In another embodiment, the epidermal disruption is performed by mechanical means. In another embodiment, “mechanical means” refers to abrading. In another embodiment, the term refers to wounding. In another embodiment, the term refers to ultrasound. In another embodiment, the term refers to radio-frequency. In another embodiment, the term refers to an electrical process or the use of an electrical current. In another embodiment, the term refers to electoporation. In another embodiment, the term refers to exision. In another embodiment, the term refers to tape-stripping. In another embodiment, the term refers to microdermabrasion. In another embodiment, the term refers to the use of peels. In another embodiment, the term refers to any other type of mechanical means known in the art. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the epidermal disruption comprises chemical treatment. In another embodiment, the chemical is phenol. In another embodiment, the chemical is trichloracetic acid. In another embodiment, the chemical is ascorbic acid. In another embodiment, the chemical is any other chemical capable of epidermal disruption that is known in the art.


Each method or type of method of epidermal disruption represents a separate embodiment of the present invention.


In another embodiment, epidermal trauma is utilized in a method of the present invention.


Each type of epidermal abrasion and epidermal trauma represents a separate embodiment of the present invention.


In another embodiment, the epidermal disruption of methods of the present invention creates an abrasion at least about 1-1.5 centimeters (cm) in width. In another embodiment, the abrasion is at least about 1 cm in width. In another embodiment, the abrasion is at least about 1.5 cm in width. In another embodiment, the abrasion is at least about 2 cm in width. Each type of abrasion represents a separate embodiment of the present invention.


In another embodiment, the scalp, eyebrow, or scarred region is not contacted with a bandage or dressing following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is not contacted with an ointment following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to facilitate healing. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to prevent infection. In another embodiment, the period of time is the time it takes the epidermal disruption to heal. In another embodiment, the period of time is any time or range of times between 2 days and 3 weeks. Each possibility represents a separate embodiment of the present invention.


In one embodiment, “following” refers to a period of time of about 2 days. In another embodiment, “following” refers to a period of time of about 3 days. In another embodiment, “following” refers to a period of time of about 4 days. In another embodiment, “following” refers to a period of time of about 5 days. In another embodiment, “following” refers to a period of time of about 7 days. In another embodiment, “following” refers to a period of time of about 10 days. In another embodiment, “following” refers to a period of time of about 2 weeks. In another embodiment, “following” refers to a period of time of about 3 weeks. Each possibility represents a separate embodiment of the present invention.


In another embodiment, a method of the present invention further comprises the step of depilating the scalp, eyebrow, or scarred region. As provided herein, the findings of Example 6 show that the efficiency of EDIHN can be enhanced by depilation prior to abrasion or wound induction.


In another embodiment, the depilation is epilation. In another embodiment, the depilation comprises the step of waxing. In another embodiment, the depilation comprises the step of plucking. In another embodiment, the depilation comprises the use of an abrasive material. In another embodiment, the depilation comprises the use of a laser. In another embodiment, the depilation comprises the use of electrolysis. In another embodiment, the depilation comprises the use of a mechanical device. In another embodiment, the depilation comprises the use of thioglycolic acid. In another embodiment, the depilation comprises the use of any other method of depilation or epilation known in the art. Each possibility represents a separate embodiment of the present invention.


In another embodiment, a method of the present invention further comprises the step of administering a topical retinoid to the scalp, eyebrow, or scarred region. In one embodiment, the topical retinoid induces resting (telogen) HF in the scalp, eyebrow, or scarred region to enter anagen. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the additional step (depilation or administration of a retinoid) is performed prior to the step of disrupting the epidermis. In another embodiment, the additional step is performed following the step of disrupting the epidermis, but prior to the addition of the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. In another embodiment, the additional step is performed concurrently with the addition of the differentiation-promoting compound or factor. In another embodiment, the additional step is performed following the addition of the differentiation-promoting compound or factor. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the additional step is performed between about two days and about three weeks before the step of abrading. In another embodiment, the additional step is performed about two days before the step of abrading. In another embodiment, the additional step is performed about three days before the step of abrading. In another embodiment, the additional step is performed about four days before the step of abrading. In another embodiment, the additional step is performed about one week before the step of abrading. In another embodiment, the additional step is performed about ten days before the step of abrading. In another embodiment, the additional step is performed about two weeks before the step of abrading. In another embodiment, the additional step is performed about three weeks before the step of abrading. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the methods of the present invention further comprise the step of contacting the scalp, eyebrow, or scarred region with an inductive cell capable of inducing an epidermal cell to differentiate into an HF cell. In another embodiment, the HF cell is an HF stem cell. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the inductive cell is a dermal papilla cell. In another embodiment, the inductive cell is a follicular papilla cell. In another embodiment, the inductive cell is a dermal sheath cell. In another embodiment, the inductive cell is a cell that has been genetically modified; for example, with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells. In one embodiment, the factor is hedgehog. In another embodiment, the factor is a DP cell protein. In another embodiment, the factor is wingless/int (wnt). In another embodiment, the factor is a Noggin protein. In another embodiment, the factor is a bone morphogenic protein (BMP). In another embodiment, the factor is a fibroblast growth factor (FGF). In another embodiment, the factor is a transforming growth factor beta (TGF-beta) protein. In another embodiment, the factor is sonic hedgehog protein. In another embodiment, the factor is a neurotropin. In another embodiment, the factor is any other factor known in the art that can contribute to induction of an epidermal cell to differentiate into an HF cell. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that represses one of the proteins or pathways shown in the present invention to be down-regulated in HF stem cells. In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells upon their activation.


In another embodiment, the inductive cell is an autologous cell. In another embodiment, the inductive cell is an allogenic cell.


In another embodiment, the inductive cell is derived from a mesenchymal stem cell. In another embodiment, the inductive cell is derived from a mesodermal progenitor cell. In another embodiment, the inductive cell is derived from a hematopoietic stem cell. In another embodiment, the inductive cell is derived from an embryonic stem cell. In another embodiment, the inductive cell is derived from an embryonic carcinoma cell. In another embodiment, the inductive cell is one of the cell types disclosed in United States Patent Application No. 2003/0201815. In another embodiment, the inductive cell is any other type of cell known in the art with inductive properties for an epidermal cell. Each type of inductive cell represents a separate embodiment of the present invention.


In another embodiment, the epidermal cell (e.g. the epidermal cell that is induced to differentiate into an HF cell) is an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF stem cell. Each possibility represents a separate embodiment of the present invention.


In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an anti-androgen compound. In one embodiment, the anti-androgen compound is finasteride. In another embodiment, the anti-androgen compound is Fluridil®. In another embodiment, the anti-androgen compound is dutasteride. In another embodiment, the anti-androgen compound is spironolactone. In another embodiment, the anti-androgen compound is cyproterone acetate. In another embodiment, the anti-androgen compound is bicalutamide. In another embodiment, the anti-androgen compound is flutamide. In another embodiment, the anti-androgen compound is nilutamide. In another embodiment, the anti-androgen compound is an inhibitor of an androgen receptor. In another embodiment, the anti-androgen compound is any other anti-androgen compound known in the art. Each possibility represents a separate embodiment of the present invention.


In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen compound. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen receptor agonist. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen analogue. In one embodiment, the estrogen analogue is estradiol. In another embodiment, the estrogen analogue is 17 beta-estradiol. In another embodiment, the estrogen analogue is 17 alpha-estradiol. In another embodiment, the estrogen analogue is ZYC3. In another embodiment, the estrogen compound, estrogen receptor agonist, or estrogen analogue is any other estrogen compound, estrogen receptor agonist, or estrogen analogue known in the art. Each possibility represents a separate embodiment of the present invention.


In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGF protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGFR. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a compound that reduces an expression of an EGF protein or an EGFR. Each possibility represents a separate embodiment of the present invention.


In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a nucleotide encoding a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an activator of a Hedgehog protein. Each possibility represents a separate embodiment of the present invention.


In one embodiment, a scalp is treated by a method of the present invention. In another embodiment, an eyebrow is treated. In another embodiment, any other hair-bearing area or region of the skin is treated. Each possibility represents a separate embodiment of the present invention.


In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a lithium compound. In one embodiment, the lithium compound contains a lithium ion. In another embodiment, the lithium compound contains a lithium atom.


In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with (2′Z,3′E)-6-bromoindirubin-3′-oxime (BIO). In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with any other compound known in the art that is capable of inducing an epidermal cell to differentiate into an HF stem cell. Each compound represents a separate embodiment of the present invention.


In one embodiment, the compound administered as part of methods of the present invention is administered systemically. In another embodiment, the compound is administered topically. In another embodiment, the compound is administered to the site of the abrasion. In another embodiment, the compound is administered to the site of the wound induction. In another embodiment, the compound is administered to the site of the depilation. In another embodiment, the compound is administered during wound healing. In another embodiment, the compound is administered prior to HF neo-genesis. In another embodiment, the compound is administered during HF neo-genesis. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a method of inducing formation of an HF stem cell, comprising performing a method of the present invention. In another embodiment, the present invention provides a method of inducing formation of a DP cell, comprising performing a method of the present invention. Each possibility represents a separate embodiment of the present invention.


In another embodiment, homologues and variants of transcripts and proteins of the present invention are administered in methods of the present invention. In another embodiment, homologues and variants of transcripts and proteins of the present invention are targeted in methods of the present invention. Each possibility represents a separate embodiment of the present invention.


The terms “homology,” “homologous,” etc, when in reference to any protein or peptide, refer in one embodiment, to a percentage of amino acid residues in the candidate sequence that are identical with the residues of a corresponding native polypeptide, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent homology, and not considering any conservative substitutions as part of the sequence identity. Methods and computer programs for the alignment are well known in the art.


In another embodiment, the term “homology,” when in reference to any nucleic acid sequence similarly indicates a percentage of nucleotides in a candidate sequence that are identical with the nucleotides of a corresponding native nucleic acid sequence.


In another embodiment, “homology” refers to identity of greater than 70%. In another embodiment, “homology” refers to identity of greater than 75%. In another embodiment, “homology” refers to identity of greater than 80%. In another embodiment, “homology” refers to identity of greater than 82%. In another embodiment, “homology” refers to identity of greater than 85%. In another embodiment, “homology” refers to identity of greater than 87%. In another embodiment, “homology” refers to identity of greater than 90%. In another embodiment, “homology” refers to identity of greater than 92%. In another embodiment, “homology” refers to identity of greater than 95%. In another embodiment, “homology” refers to identity of greater than 97%. In another embodiment, “homology” refers to identity of greater than 98%. In another embodiment, “homology” refers to identity of greater than 99%. In another embodiment, “homology” refers to identity of 100%.


Protein and/or peptide homology for any amino acid sequence listed herein is determined, in one embodiment, by methods well described in the art, including immunoblot analysis, or via computer algorithm analysis of amino acid sequences, utilizing any of a number of software packages available, via established methods. Some of these packages may include the FASTA, BLAST, MPsrch or Scanps packages, and may employ the use of the Smith and Waterman algorithms, and/or global/local or BLOCKS alignments for analysis, for example. Each method of determining homology represents a separate embodiment of the present invention.


In another embodiment, the present invention provides a kit, comprising a tools and/or a compound suitable for performing a method of the present invention.


In another embodiment, the present invention provides a device, comprising a tool suitable for epidermal disruption and a means of delivering a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell.


In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. Each disease, disorder, or symptom represents a separate embodiment of the present invention.


Pharmaceutical Compositions

In another embodiment, methods of the present invention comprise administering a pharmaceutical composition comprising the HF stem cell-inducing or -activating compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof; and a pharmaceutically acceptable carrier. Each possibility represents a separate embodiment of the present invention.


The pharmaceutical compositions containing the HF stem cell-inducing or -activating compound can, in another embodiment, be administered to a subject by any method known to a person skilled in the art, such as topically, parenterally, paracancerally, transmucosally, transdermally, intramuscularly, intravenously, intradermally, subcutaneously, intraperitonealy, intraventricularly, intracranially, intravaginally or intratumorally. Each possibility represents a separate embodiment of the present invention.


In another embodiment, the pharmaceutical compositions are administered orally, and are thus formulated in a form suitable for oral administration, i.e. as a solid or a liquid preparation. Suitable solid oral formulations include tablets, capsules, pills, granules, pellets and the like. Suitable liquid oral formulations include solutions, suspensions, dispersions, emulsions, oils and the like. In one embodiment of the present invention, the HF stem cell-inducing or -activating compounds are formulated in a capsule. In another embodiment, the compositions of the present invention comprise, in addition to the HF stem cell-inducing or -activating compound active compound and the inert carrier or diluent, a hard gelating capsule.


In another embodiment, the pharmaceutical compositions are administered topically to body surfaces and are thus formulated in a form suitable for topical administration. Suitable topical formulations include gels, ointments, creams, lotions, drops and the like. For topical administration, the HF stem cell-inducing or -activating compound or its physiologically tolerated derivatives such as salts, esters, N-oxides, and the like are prepared and applied as solutions, suspensions, or emulsions in a physiologically acceptable diluent with or without a pharmaceutical carrier.


In another embodiment, the pharmaceutical compositions are administered by subcutaneous implantation of a pellet. In another embodiment, the pellet provides for controlled release of HF stem cell-inducing or -activating compound agent over a period of time.


For liquid formulations, pharmaceutically acceptable carriers are, in another embodiment, aqueous or non-aqueous solutions, suspensions, emulsions or oils. Examples of non-aqueous solvents are propylene glycol, polyethylene glycol, and injectable organic esters such as ethyl oleate. Aqueous carriers include, in another embodiment, water, alcoholic/aqueous solutions, emulsions or suspensions, including saline and buffered media. Examples of oils are those of petroleum, animal, vegetable, or synthetic origin, for example, peanut oil, soybean oil, mineral oil, olive oil, sunflower oil, and fish-liver oil.


In one embodiment, the pharmaceutical compositions are controlled-release compositions, i.e. compositions in which the HF stem cell-inducing or -activating compound is released over a period of time after administration. Controlled- or sustained-release compositions include, in another embodiment, formulation in lipophilic depots (e.g. fatty acids, waxes, oils). In another embodiment, the composition is an immediate-release composition, i.e. a composition in which all the HF stem cell-inducing or -activating compound is released immediately after administration.


EXPERIMENTAL DETAILS SECTION
Example 1
Depilation and Epidermal Abrasion Causes De Novo Hair Follicle Formation
Materials and Experimental Methods
Depilation and Epidermal Abrasion

Mice were anesthetized with an injection of sodium pentobarbital before the hair on the back was clipped and depilated with Nair (Carter-Wallace, New York, N.Y.), then epidermis was removed using a rotating felt wheel as described by Argyris T, J Invest Dermatol, 75: 360-362, 1980). After scrubbing with 70% ethanol and drying under an incandescent lamp, the basal and supra-basal layers in an area of (1.5 cm)2 cm of the inter-follicular epidermis were removed by careful abrasion with a felt wheel mounted on a Dremel Moto-tool (Racine, Wis.). After abrasion, the skin was shiny and smooth, and there was no blood. One day later, the abraded area was covered by a fibrin crust, which fell off after 3-7 days, exposing the newly regenerated epidermis. A group of control mice was sacrificed immediately after abrasion to confirm microscopically the complete removal of the interfollicular epidermis.


Immunohistochemistry

Skin samples were fixed in PBS-buffered 10% formalin. Six-micron thick paraffin sections were cut and stained, where applicable, with antibodies.


BrdU Labeling

The protocol described by Bickenbach and colleagues (Bickenbach et al, Cell Tiss Kinet 19: 325-333, 1986; Bickenbach et al, Exp Cell Res 244, 184-195, 1998) was used. Mice were injected with 50 milligrams per kilogram (mg/kg) bodyweight 5-bromo-2′-deoxyuridine (BrdU) every 12 hours for a total of four injections.


Results

An area of the backs of 50-day old mice was subjected to depilation and removal of the epidermis using a rotating felt wheel. Fifteen days later, HF placodes, hair germs and other signs of follicle neogenesis were present (FIG. 1; arrow indicates a hair germ). Morphology of the follicles was similar to embryonic follicle development. To further characterize proliferation in the new follicles, the skin was labeled with BrdU 60 minutes before sacrifice. As depicted in FIG. 2, the proliferation pattern was similar to developing follicles in the embryo.


These findings demonstrate that (a) disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (50-day-old mice are in the second telogen stage of the hair cycle).


Example 2
Induction of a Large Excisional Wound, but not a Small Punch Wound, Causes De Novo Hair Follicle Formation
Materials and Experimental Methods
Punch Wound and Excisional Wound Induction

The backs of 21-day-old mice were depilated as described for Example 1 and sterilized with alcohol, followed by 1% iodine solution. Punch wounds, 4 mm in diameter, were induced using a dermal biopsy punch, down to, but not through, the muscle fascia. Excisional wounds were full thickness and 1 cm in diameter; skin and panniculus carnosus was excised using fine surgical scissors.


Results

To test whether wounding could induce HF formation, punch wounds or excisional wounds were induced in mice. Both types of wounds exhibited contraction and re-epithelialization following wound induction; however, unlike the mice receiving punch wounds, the mice receiving excisional wounds also exhibited scar formation within 10 days of wound induction (FIG. 3, left panel). No follicles were evident at this time point (FIG. 3, right panel). 12 days after wound induction, hair germs, with similar morphology to fetal hair germs, were observed in the wound site, following BrdU pulse labeling (FIG. 4). Several markers were used to verify that the observed structures were HF. The structures exhibited staining with anti-keratin 17 (K 17), an HF marker (FIG. 5), and staining with anti-alkaline phosphatase at the 12 day time point verified that the structures had dermal papilli containing fibroblasts, as expected for HF (FIG. 6; HF at earlier and later stages are depicted in the left and right panels, respectively).


The HF generated by wound induction were further characterized by morphological comparison to embryonic HF, following BrdU staining; a clear correspondence in morphology was observed at various stages (FIG. 7). In addition, several markers of embryonic HF development, namely Lef1, wingless/int (Wnt) 10b, and sonic hedgehog (Shh), were also induced in the epidermal disruption-induced HF neogenesis (EDIHN) (FIG. 8). Additional BrdU staining (FIG. 9) and staining for HF markers S100A3 and S100A6 (FIG. 10; left panel: tissue section parallel to HF axis; right panel: cross-sectional view of follicle) provided further verification that the development of the EDIHN follicles closely paralleled embryonic HF development.


These findings provide further evidence that disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (21-day-old mice are in the first telogen stage of the hair cycle).


Example 3
EDIHN-Induced Hair Follicles Generate Hairs

At 25 and 45 days after wound induction, wound sites contained new hairs (FIG. 11, left and right panels, respectively). New hairs appeared to lack pigmentation, except when the wnt pathway was inhibited, using Dkk-1 (Dickkopf-1) during the first nine days after wounding (see Example 10).


These findings indicate that EDIHN-induced HF function normally; i.e. are capable of generating hairs.


Example 4
EDIHN Hair Follicles Retain the Ability to Enter into Cyclical Hair Growth
Materials and Experimental Methods
BrdU Labeling

50 mg/kg bodyweight BrdU (Sigma) was injected twice per day for 3 days beginning 20 days after wounding. BrdU was detected 40 days after wounding (17 day chase).


Whole Mounting and Immunofluorescence

HF whole mounts were obtained by incubating fresh skin with EDTA (20 mM in PBS) at 37° C. overnight, then separating the epidermis and dermis. Epidermis was then fixed in 10% formalin for 10 min, room temperature (RT). Dermis was fixed in acetone overnight, RT. After rinsing with PBS, whole mounts were stained with antibodies for immunohistochemistry (schematically depicted in FIG. 12) and were imaged using a Leica confocal microscope.


Results

To determine whether EDIHN-induced HF contain normal levels of HF stem cells, mouse skin was examined for the presence of label-retaining cells at 21 days after wound induction. Retention of BrdU during a long chase period is, under these conditions, one of the hallmarks of HF stem cells. Normal numbers and placement of label-retaining cells (in the bulge of the HF) were observed (FIG. 13). To verify that the label-retaining cells were HF stem cells, K15-eGFP mice were utilized. In these mice, eGFP (enhanced green fluorescent protein) is expressed from the K15 promoter; thus, expression of eGFP identifies HF stem cells. As depicted in FIG. 14A, eGFP-expressing cells were observed in tissue sections (right side) of newly formed hair follicles 35 days following wound induction. eGFP-expressing cells were also seen in the epidermis whole mounts (bottom, far left panel) indicating the conversion of epidermal cells into cells with hair follicle stem cell characteristics. (panel is same as panel but viewed under white light) This finding shows that the observed label-retaining cells exhibited HF stem cell properties.


To determine whether EDIHN-induced HF cycle normally, mounts were prepared from additional mice at 35, 38 and 45 days after wounding. As depicted in FIG. 14B, the EDIHN-induced HF entered the resting phase, telogen, and then re-entered a new anagen stage.


In summary, the findings of this Example show that EDIHN-induced HF contain HF stem cells, as do embryonically generated HF. The presence of the HF stem cells shows that EDIHN-induced HF retain the ability to enter into cyclical hair growth in the same manner as embryonically generated HF. The findings also show that wounding induces epidermal cells to assume a hair follicle stem cell state (expressing K15-eGFP). This model is shown schematically in FIG. 15. The findings of Examples 2, 3, and 4 show that EDIHN-induced HF are fully functional and thus able to restore hair growth to a subject in need.


Example 5
EDIHN-Induces New Hair Follicles in Mice at the Telogen Stage of the Hair Cycle

To determine whether EDIHN was induced new hair follicles in mice wounded at the telogen stage of the hair cycle, 21-day-old mice were subjected to EDIHN using a 1-cm excisional wound, as described in Example 2. Skin was then examined by whole-mount assay for indications of new HF. As depicted in FIG. 16, after 11 days, new HF were not evident by macroscopic examination (top panel), AP staining of the dermis (bottom left panel), or K17 staining of the epidermis (bottom right panel). After 14 days, as depicted in FIG. 17, dermal papilla cells were detected in the dermis (left panel) and HF stem cells in the epidermis (right panel), demonstrating that new follicles were being formed. After 17 days, the new follicles were more developed, as shown by examination of the dermis and epidermis (FIG. 18, left and right panels, respectively). This method induced formation of an average of 49 new follicles in the wound, a number that was consistent over three separate experiments, as depicted in Table 1.









TABLE 1







Results of three separate experiments


performed on 21-day-old mice.












Sample
Expt 1
Expt 2
Expt 3
Avg of expts
Std dev of expts















1
24
70
55




2
29
52
25


3
27
85
53


4
102
25
80


5
53
27
23


Average
47
51.8
47.2
48.67
2.71


Std dev
32.8
26.3
23.7









The findings of this Example demonstrate that EDIHN is capable of inducing formation of new HF in mice at the telogen stage of the hair cycle, despite that fact that these mice do not contain HF at the anagen stage during wounding.


Example 6
In Adult Mice, Induction of Anagen Increases the Efficiency of EDIHN

The experiment described in Example 5 was repeated with mice of different ages, and therefore at different stages of the hair cycle. To ensure that wound scarring occurred, larger wounds were in induced in the older mice. As depicted in Table 2, adult mice at telogen, such as 8-week-old mice, exhibited lower efficiencies of HF formation by EDIHN.









TABLE 2







Efficiency of HF formation by EDIHN in adult


mice at various stages of the hair cycle.












Wound
Days after
Mice exhibiting



Age
size
wound
EDIHN
Hair cycle

















3
wk
1
cm
20
25/25
(100%)
Telogen


4
wk
1
cm
20
5/5
(100%)
Early anagen


5
wk
1
cm
20
1/2
(50%)
Anagen


8
wk
1.5
cm
30
16/35
(46%)
Telogen


14
wk
1.5
cm
30
1/2
(50%)
N/A*


20
wk
1.5
cm
30
2/2
(100%)
N/A*





*The second telogen lasts approximately 40 days in mice. Thus, 14-week-old and 20- week-old mice contained a mixture of telogen and anagen HF.






To determine whether experimental induction of anagen increased the efficiency of EDIHN, 8-week-old mice were depilated several days prior to wound induction. As depicted in FIG. 19, the wounds closed similarly whether or not they were preceded by depilation. As depicted in FIG. 20A-B, the depilated mice exhibited enhanced EDIHN relative to the non-depilated mice depicted in the previous Example by a factor of 11-fold.


The findings of this Example demonstrate that anagen induction enhances EDIHN. In addition, these findings show that EDIHN is capable of not only forming new HF, but also of activating anagen in pre-existing HF in the telogen stage.


Example 7
EDIHN-Induces New Hair Follicles in Human Skin
Materials and Experimental Methods
Grafting

Discarded human adult scalp from the preauricular area obtained from plastic surgery was grafted onto immunodeficient (scid) mice. The graft was bandaged and allowed to heal, then was used in the wound healing study 3 months after grafting.


Results

To determine whether human skin responded to EDIHN as did mouse skin, human skin was grafted onto SCID (immuno-deficient) mice and subjected to depilation by plucking and wound induction three days later. Seven days following wound induction, formation of new HF was observed in the human skin (FIG. 21A; arrows indicate new HF) by hematoxylin and eosin staining of paraffin embedded tissue sections.


In additional experiments, adult human skin was grafted onto mice, abraded, and examined at 7 days post-abrasion. New HF were generated in the human skin, which mimicked normal hair follicle formation during fetal development, as evidenced by staining for S100A6 or S100A4 (FIG. 21B).


The results of this Example show that EDIHN can be used to generate hair growth in human skin as for mouse skin.


Example 8
Molecular Pathways Activated During HF Stem Cell Activation
Materials and Experimental Methods
Isolation and Activation of HF Stem Cells

K15-eGFP mice were depliated in order to induce formation of new HF. Activated hair follicle stem cells were isolated from K15-eGFP mice using fluorescence-activated cell sorting (FACS) two days after depilation and 5 μg (micrograms) total RNA from the cell population was isolated, reverse-transcribed and hybridized to an Affymetrix (Santa Clara, Calif.) array MG_U74v2 chip. Scanned chip images were analyzed using Affymetrix Microarray Suite 5.0 and GeneSpring software (Silicon Genetics) to detect fold-change differences between activated HF stem cells (HFSCs) and non-activated (telogen) HFSCs. Values were normalized before computing fold-changes and differences between non-activated “bs-line” and activated (“expt”) samples.


Results

To identify molecular pathways up-regulated during HF stem cell activation, activated HF stem cells were isolated, and the gene expression patterns of the cells were analyzed to detect up-regulated transcripts. The transcripts depicted in Table 3 were up-regulated at least 2-fold in the activated HF stem cells relative to the cells prior to activation. In some cases, the sequence in Table 3 is a genomic sequence that contains the sequence of the transcript. Data pertaining to the up-regulation of the transcripts and further information about them is provided in FIG. 22.









TABLE 3 





RNA transcripts up-regulated during HF stem cell activation.

















SEQ




ID




No:
Access. #
Sequence





1
AW047343
uuuuuuuuuuuuuuuuucuuaaaaauauaaauguauuugucugcaucaugacguucuucg




ggcaccuagcuggccagaccacuggccaugggacaaggaggaagucagguguaagucugag




caaggaacaggacucugcccuggcaggguggagguggccucacagugucccaugcugggcc




ugguagcgugaaagcacagcacgguagugggacagcuccugccgcacagccaccaccuccu




gccgcaacagggcguuuuccuucuccaggaaggcagcccgcacagauauccgguucuccuu




gagucuucuugcaucuc





2
AF053235
Sequence below.










caguuccucagcauggccaccugcagccgccaguucaccuccuccagcuccaugaagggcuccuguggcaucggugguggc


ucuagccgcauguccuccauccuggcuggaggauccugccgggcucccagcaccugcgggggcaugucaguuaccuccucu


cgcuucuccucugggggagucugugggauuggagguggcuauggugggagcuucagcagcagcaguuuugguggaggac


uugguaguggauuugguggucgauuugauggauuugguggugguuuuggugcuggucuuggugguggucuuggcggu


gguauuggugaugggcuccuggugggcagugagaaagugaccaugcagaaccucaaugaccgccuggccaccuaccuggac


aaggugcgugcccuggaagaggccaacagagaccuggaggugaagauccgggacugguaccagaggcagcggcccacugag


aucaaagacuacagccccuacuucaagaccauugaggaccugaagagcaagaucauuauugccacccaggagaaugcacagu


ucacuuugcagauugacaaugccaggcuggcagcugaugacuucaggaccaaguacgagaaugagcuguucuugcggcagu


ccguggagggugacaucaauggccugcgcaaggugcuagaugagcugacccuguccagagcugaccuggaaaugcagauug


aaaaccucagagaagagcuggccuuccugaagaagaaccaugaggaggagaugcuugccuugaggggucagacuggugggg


acgucaauguggagauggacgcagcccccgguguggaccucagccgcauucugaaugagaugagggaccaguaugagcaga


uggcagagaagaaccgcagagauguggaggccugguuccugagaaagacugaggagcugaacaaagagguggccucuaaca


gugaucuaauccagagcaaccgcagcgagguggcugagcuccgcaggguguuccagggccuggagauugaacugcaguccc


agcucagcaugaaagcauccuuggagaacagccuagaagagaccaaaggcagauacuguaugcagcugucccagauccaggg


uuugaucagcaguguggaggagcagcuggcucagcuucgcugcgagauggagcagcagagccaggaguacaacaucuugu


uggaugugaagacaaggcuggagcaggagaucgccaccuaccgccgucugcuggauggcgagaauauccacuccuccucac


agcacuccucuggacaguccuauucuucucgagaagucuucuccucauccucccgccagccccgguccauccucaaggagca


agguucaaccagcuucagccagagccaaagucagaguuccagggacuaauguuuugccuagagccuccucacccacaacugc


cucucaagcugagggcuuggggcaggacccuguuuucuuugcgcauuccccaucugucuccccuacccucucaugguggu


aggcuaauaaagcuuuuugguugaugcaaaaaaaaaaaaaaaaaa












3
M26005
gcgccaguccuccgauagacugagucgcccggguacccguguucucaauaaagccucuug




cuguuugcauccgaaucguggucucgcugguccuugagagggucuccucagauugauugac




uacccacgucgggggucuuucauuuggaggccccagcgagauuuggagaccccugcccagg




gaccaccgaccccccgucgggagguaagcuggccagcggucguuucgugucugucucuguc




uucgugcguguuugugccggcauuuaauguuugcgccugcgucuguacuaguuagcuaac




uagaucuguaucuggcgguuccgcggaagaacugacgaguucguauucccggccgcagccc




cugggagacgucccagcggccucgggggcccguuuuguggcccauucuguaucaguaacca




cccgagucggacuuuuuggagcuccgccacuguacguggcuuuguugggggacgagagaca




gagacacuucccgcccccgucugaauuuuugcuuucgguuuuacgccgaaaccgcgccgcg




cgucugauuuguuuguuguucuuuuguucuucguuaguuuucuucugucuuuaaguguu




uuucgagaucaugggacagaccguaacuaccccucugaguuuaaccuugcagcacugggga




gauguccagcgcauugcauccaaccagucuguggaugucaagaagaggcgcuggauuaccu




ucuguuccgcugaauggccaacuuucaaugugggauggccucaggaugguacuuucaauuu




aaguauuaucucucagguuaagucuagaguguuuuguccugguccccacggacacccggau




caggucccauauaucgucaccugggaggcacuugccuaugaccccccuccgugggucaaacc




guuugugucuccuaaacuuccucccucgccgacagcucccguccucccgcccgguccuucug




cgcaaccuccgucccgaucugcccuuuacccugcccuuacccccucuauaaaguccaaaccuc




cuaagccccagguucucccugauagcggcggaccccucauugaccuucucacagaggaccuc




ccgccguacggagcacaaccuuccuccucugccagagagaacgauaaagaagaggcggccac




caccuccgagguuucccccccuucucccauggugucucgacugcggggaaggagagacccuc




ccgcagcggacuccaucaucucccaggcauucccacuccgcauggggggagauggccagcuu




caguacuggccguuuuccuccucugauuuaacccuuccuuuucugaagauccagguaaauu




gacggccuuga





4
AA681998
gacguagagccccuugcgcccgguuuccugaucccgcuuacuccucugcgcgccggcagga




uggcccacaagcagaucuacuacucagacaaguacuucgaugagcacuacgaguaccggcau




gucauguuacccagagaacucucuaaacaaguacccaaaacucaucugauguccgaagagga




guggaggagacuugguguccaacagagucuaggauggguucauuacaugauucaugagcca




gaaccgcauauucuucucuuuagacgaccucuuccaaaagaacaacaaaaaugaagugcagc




ugggaucaucuaaucuuuuucaaauuuaauguauauguguauauaagguaguauucaguga




auacuugaaaaguguacaaaccuuucauccauaccugugcaugcgcuguauucuucacagca




acagagcucagucaaaugcaacugcaaguagg





5
AF057156
atuaaaaagccagcugcccaaugccugcacacagaauccacaccaacagagaaccugcucuuc




ucugaguauuagguaagucucugcuugcaacugauuugaaauucuugcuuauuuuuuuac




uaugaaaaacuguucaaagccaacucuauuacagaguugauguggggugcugccuacaguu




agugaacaguagcauuguuugcuuaaauuauagcacauuuugggucuaggaacuugagagg




ugauucaguuggucacuguaguagacagccuuggaaucagagauuaaggcaaaaggaaacc




uccauucaaauauucauggaaguucacagcuggagacagguuaaggcuucaguccagauag




cuuucagaauuauugcaguucuuacugauaggcauaucaauagcgaaauuuaauuuauuag




aggaaucuacuaaaguaaauuuuuaggccaauauagaacauaccauacuuguagucuggcag




agaaggugacauaugaaauugaaaugcgauucauagacagugguagugaaagaaauaaugg




uggggangggcugugcangggaggcauggcucaaggacagcacuuagugguagcacacacc




augaacuaugauggaaaagcauuugauaggcagagacagaaauguaggaaauguguaggga




uccaugagagcauaaacuaaaagggcaaaagcauaugagcauggacuaacaugcagccacuc




ugcaaguuauacuaugaucuauuucacaaggagguugguaugcugcugucuuugggugac




accgcuuucccagauguccugguguguagguucacaagccucucagaagccauacuuuauu




gcuuuuuaagacguauuauuaauauuuuggcuagcauaugguuuagugugagaguuuuau




augcauaugucauuauacuuugcucauuuaugucuuggaacuucuucaacuagguagaaaa




caugaccagggagaaugagaguaaggaaagaacccacugagacagacaagagcaaaccauac




uucugcuaaucauguuuaaaaguccagaaaugaucauaccauauuuuauuuucaagugugg




aagucagcauggagaggggcucuuuuucucuaaaggggccugaaauuaaauugacuugaug




uugagguuaccuucucuuucaaugaaucacuaaauugucuuuucuguuucccaggacccaa




gugcuaucuaaccaugaguucccaccagcagaagcagcccugcacuguaccuccucagcugc




accagcagcaggugaagcagccuugccagccaccaccccaggaaccuugugcccccaaaacca




aggaucccugccacccuguuccugagcccugcaaccccaaggggccagagcccugccacccc




aaggcacccgagcccugccaccccaaggcaccugagcccugcaaccccaaggugccagagccc




ugccagccuaaggugccagagcccugccagccuaaggugccagagcccugcaaccccaaggu




gccagagcccugccaaccuaaggcaccagagccuugccaccccaaggcgccugagcccugcca




cccuguuguucccgagcccugccccucaacugucacuccaucaccauaccagcagaagacaaa




gcagaaguaauauuguccagagccaugccugaagaccugaucaccagaugcugaggcugcu




gucuauccugcuuaugagucccauugccuugugcuaccaaugcugugaccuucagucuuaa




ucccucucuccuugcaccaccuaaaaaguugacucucauccucaucuucaagggcuccugag




ccucuuaacauugcccaaagucauauugaauggcuacacuuuucauggcucaggauucauc




ugaagggggugaggagugagacaaguguauggucaauauuuuccccccauuaaaugccauu




uaacucc





6
AI845584
uuuuuuuuuuuuuuuuuagccaaaauaguuauuuauuaauaauuuaagguuuuacauucu




uauaauaaauuccagcucaaaacuuuacaccacgaacaucauggagcaaguuaauucucccu




uccucucaaccuguugcauccaccaaaugggcgcucauacucgcacacauacacacacuucca




guuucguauuuuuuuuuaaaaggaaagaaaccaacccaaaguauugcauuugaggugacac




ucccugaa





7
AA614971
aagaugcccuuuggauuggauuggauugaucauguuuaacucagcguauuuuauggauga




aagcuaaauacagauauuuggcaucucuaagguggaaugagcccacuccacacacugauaaa




auucaugcauaguuu





8
AV374591
aaccaaaugggaaugggguccccaacnuuncugugguaccagccggguuucucuugcauug




gaaacaaacaccuuuguaggcauuugcguauucgugaagagacuguuuuaugaaucaccuc




uuagauuuaunuaauuaaccuaaguuguugaaguuucuguuucuccuuaagagaaauuaca




aaaauucaacauugaagcauaguuucuuguuuucuguugucaaauaguaauaaugugcugu




gauguuuaugcuuauucauaaagauguuuuacuuuuuaguguaauguuaguucuuuuuaa




cauuauuuugcuuaaauuugauaaugcccgacaagaauauauuuugcuuugauuuauacac




ugauucuuugugacaaauaugacccauuaaaaaugccuuuuaauagacuaacuuaccuuuu




guagcuagguacucauguucuuuuuuaaaagaugcccuuuggauuggauuggauugauca




uguuuaacucagcguauuuuauggaugaaagcuaaauacagauauuuggcaucucuaaggu




ggaaugagcccacuccacacacugauaaaauucaugcauaguuuuaaaugaacauuaauaaa




cucauguugucuu





9
U04443
gaauucaaggaggcuuuccagcuguuugaccgaacaggugauggcaagauccuguacagcc




aguguggggaugugaugcgggcccugggccagaacccuaccaacgccgaggugcucaaggu




ucuaggaacccccaagagugaugagaugaaugugaagguacuggacuuugagcacuuccug




cccaugcugcagaccguggcgaagaacaaggcccagggaaccuacgaggauuauguugaagg




ccuucguguguuugacaaggaaggaaauggcaccgucaugggugcugaaauccgucauguc




cuagucacacugggcgagaagaugacagaggaagaaguagagaugcuaguggcagggcaug




aggacagcaaugguugcaucaacuaugaagcauuugugaggcauauccugucggggugacg




ggcccgauggggcggagcucguccggauggugcugaauggcugagacauucuguaucccga




gucuguucccugcccagugugauuucuguguggcuccagacgcuccccugucacagcaccu




ugucccauuugguuucuuuggaugauguuugccuucaccaaauaaaauuugcucucuuugc




cc





10
Y07836
caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucaggg




auggauuuugcccacauguaccaaguguacaaguccaggcggggaauaaaacggagcgaa




gacagcaaggaaacuuacaaacugccgcaccggcugauugagaaaaagagacgugaccgg




auuaacgagugcauugcccagcugaaggaucuccuacccgaacaucucaaacuuacuacu




uugggucacuuggaaaaagcagugguucuggagcuuacguugaagcacgugaaagcauuga




caaaucuaauugaucagcagcagcagaaaaucauugcccugcagagcgguuuacaagcuggu




gauuugucgggaagaaaucucgaggcagggcaagaaauguucugcucagguuuccagacuu




gugcccgugagguacuucaguaccuggcgaagcaugagaacacucgggaccugaaaucuuc




ccagcucgucacucaucuccaucguguggucucggagcugcugcaggguggugcuuccagg




aaaccauuggacucggcucccaaagccgucgacuugaaagagaagcccagcuuccuagccaa




gggaucagaaggcccagggaaaaacugugugccagucauccagcggacuuuugcucccucg




gguggggagcagagcggcagugacacggacacagacaguggcuauggaggugaauuggaga




aaggggacuugcgcagugaacagccguacuucaaaagcgaccauggacgcagguucgccgu




gggagaacgugucagcacaauuaagcaagaauccgaagagccccccaccacaaagagccgaau




gcagcucucagaagaggaaggccacuucgcgggcagugaucugauggguuccccauuucuu




gggccacacccacaucagccuccuuuuugccuucccuucuaucucaucccaccaucggccac




ugccuaccugccuaugcuggagaaaugcugguaccccaccucugugccaguguuauaccca




ggccucaacaccucagcugcagcccucuccagcuucaugaacccagacaagauaccgacuccc




uugcuucugccccagagacucccuucuccuuuggcacauucgucccuugacucuucggccu




ugcuccaggcuuugaagcagaucccuccuuuaaacuuagaaaccaaagacuaaacucuggag




ggaucuccugcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccuga




gugcagagagaucagcccacccugcagacccacagagaagauucagagugugugugagagu




gagugagugugcgugcgugcgugcuuguauguauguuuguauauguaggacaauaaguuc




cuucugacacaagggagacacgagaaggauagccugacaucagaugacagacuggaggacug




uagcacaucucugggcguuucccuacccagagaagagcc





11
M21285
Sequence below.










uugcaggcgagggcuuccacaacuaccaccacaccuuccccuucgacuacucugccagugaguaccgcuggcacaucaacuu


caccacguucuucaucgacugcauggcugcccugggccuggcuuacgaccggaagaaaguuucuaaggcuacugucuuagc


caggauuaagagaacuggagacgggagucacaagaguagcugagcuuugggcuucugaguuccuguuucaaacguuuucu


ggcagagauuuaauauucuguugauuaacuaacaacuggauauugcuaucgggguguuaaugaugcauuuaaccuauucc


gguacaguauucuuauaaaaugagaaagcuuugaucacguuuugagguaauaaauauuuuauuuagcuaggauuaaccau


gccacaagacauuauauauuucuaagcacacaugauaaaugcauauacaauuuugcacaacagcuuuaaauaauaacaauaa


auuugaacauucuauacagagaggaucaaagccaaggaacaugcuguuuugaugcuagggugagcauggugcucagucccu


guuuguuugcaugguguccagcuuuguuucuucucugucaucaccaccuucaggcaaauaguugaccaaccacuggccug


ugucuguccacccuccaaagcccaggccaccuuucuguuuucugaaauacugauccuuccuccugaauacaucccuccuug


uuccuagcuucaagacugcugccucaaauagggauagagcaaguccccgcugcagguugugcuagaugggauggagaaauu


aucuucauuugauacagagcaaguagauugucucgagagaaaaguuagcaugcgugguaugauuuguaaguaaagaugga


agagagagagagagagagagagagagagagagagagagagagagagguagccauaucuaacagccuacuuaccaaagacccc


aggccucucugcuuggcaugccuccuuucuguccauccucugaaccccagagauuagugagauuugaauaauuaaaucauu


uucagagugaaggggguuaaugcagggucugugcuaggggaggguuuuagcuuuugguaacugaagauuuuuucaugga


aaaagucuucguguucaaugugccuagaacugauaacuaaacagcugacauuugucggggacagauauggugugaaacuau


gaaaauauaagcaaaaucuucacuuggaacaugaaacuauuucacuuagaaaauaaucgaaggacccgagguguugccugg


guugccaguuucuuucguggcugggcaggaacuagugagguugaggggcagugucuguaaguagcugcuaagaggugca


uuuccagaugaagcccuuggggaacaucugccagggauccgcaugguguuggcuccauccauugcuuuaguuuccuccuu


ggauuguguagaaacuuggcuucccaugguuuugaaccuuccaugccuucuuugcuuuguggccacccagccugccuagu


gcugccuaggaagcucuuacccaccugauuucuucugacauuucuuucuuuggccuuuuuuucuuucuccggacaugcag


cuaguugccugaguguaucaagagcacccaggacuugcugcuguccaggccuguuccucccccaguauccgugggugugg


aagagcuguguagcuucaggaagcagagccaggugccaccuuucuguggcuuccagauccucccuaccuccaacucaugug


ccucugucacagugauuucaggaaagcuugguagacccucuagcaacaucucgguucagaaagucucucugguuugugag


uuaacagcucagcuaagugcuguuuugucucagugaguuaaccacugaaugcgaggguugguuguugaucugucucggug


ugugucggaguagacagcauaugcacuucucccugugcgcuuugcaagguaauguggcuuuggcugauccaugcaggcag


guagugguacagugcugcugaaaggaagaaguuccccauuuuaucuguuaaaacaccagagacaugggcaagugcuaaugg


accucacuucaggaagagggucugcuuccugaagccagugugugaugaaaagugacugagaccugauaucuaaggugagac


cugauaccuaacacucugucacacaguccagggccaacagugcuauaggaaagucuagaagaaaacaucacaucaguauuuu


agaaccaucaaccaucucuugucccuauagcccaauccagaggccugguuuuuagaacuggcuguguaaggugccaaacac


ucaguucacuuguagaaucagagccuuuuuuccccccuauguuaauugaacacgcgcucugagcuguuuuguugaaguag


aaaaucucauagaaaaaucacuguagaucuacugaccuauagcccucuggaaaugccuuugagaugguuuuacuuuucuag


gucauagaugccugauuauaaagaugaacaauaaaaucagcuuucuuucuuucucuucugaucuuauuccccagaucugau


ucaggccauguuccaaagcaaggcuacauugagguccuggugucuuuaaguaaaggacaucuuucagauccucucaaagaa


ggauuuauaacaguuuccagaugaauguacuaauagcuuugggugccuuaucucuuuccuaaucuguagugccugugagc


ucagucucacuccuucccuuagcccggagaccccuuagaucgagugggaauagucaagaggcuggcuggagagucaucagu


acauugguuugcagaaaucuuuuacaggcuacauuuuggaauuuuuuuuuuuuuaguaagugaucaaauuuggugggaa


guaauucgaguguauucgauuguauugucguccucguuaucauugucaaacauguuauagacggcaguuggcacuggggc


ugcuaaucucuggguguagucucugaaacuguagcuccagugagguggugugaaagguuagcaaagccaccaucugcugg


ugcuccagccaaggugccucuuagccacugaauugcuauguuauccuuucucuuguaacaaacccaccccagagauaaagcc


uuuaaucaacccaagaaacuccugggcuaaguaucugacagucucacaucucaacagugugaauuaaguguccauagcauca


gcucaggaggacacucugggagagugcugacaaaaaaggguuauuaauacugaccuacuacuucaagggcaguucugaggu


gauuagagcuuuuuuuaaaaaccaaguauuuggggauccucagcagagguauucauacagacucccaaagaacuauauaug


uuccugagaccaucguuuagucuacauugcucuucccagagacugacagauaugaccagucaaagugcaagacuaccuaccc


acugccaugaaaaccauugcaggaaaccuuucccuuccugaaugagauuuuuuuuuucccuuuuuaugugggguaauuau


uugugacccaaguguaauuuggaugauuuccauuaauaucaacucuugaagccuacuuguacugauugagauuguauuug


uuccuaauaaaaguggaucugguuguacuguc












12
V00756
accacuugcagacaaaugaauuccuucgaaauguauuugagguuggacccccugugaugcu




ugaugcugcaacacuuaaaaccaugaagauuucucguuuugaaaggcauuuauauaacucu




gcagcuuucaaagcucgaacaaaagcucgaagcaaaugccgagauaagagagcagauguugg




agaauucuuguagaugucugaauuugauggcuguuuucuaaucucuuccuuuauuauuau




uuuugcuacuucuaauguauauaagcuuuuagagacaguuuuuuaucuuggucaacuuaaa




uaauuuuugauguagggguggguuguauuuuaauuuaauguacaguguuacaaauuaaug




aguucuuuauucucuguaaaaauaacugguaaccacaaauaaaguguuugugauguuuggu




cgu





13
Y14296
auguccgcggccgccuacauggacuucguggcugcccagugucugguuuccaucuccaacc




gcgccgccgugccggagcacgggggcgcuccggaagccgagcggcugcgacuaccugagcg




cgaggugaccaaggaacacggugacccgggggacaccuggaaggauuauugcacgcugguc




acuaucgccaagagcuuguuggaccucaacaaauaccgacccauccagacccccucggugug




cagcgacagucuggagagucccgaugaggauauaggauccgacagcgacgugaccaccgaau




cugggucgaguccuucccacagcccggaggagagacaggauucuggcagcgcgcccagccca




cucucccuccuccacucuggaguggcuucgaaggggaaacacgccuccgaaaagaggcacaa




gugccccuacaguggcugugggaaagucuauggaaaauccucccaucuuaaagcccauuaca




gagugcauacaggugaacggcccuuucccugcacguggccagacugccuuaaaaaguucuc




gcgcucggaugagcugacccgccacuaccggacccacacuggggaaaagcaguuccguugcc




cacugugugagaagagauucaugaggagugaccaucucaccaagcaugcccggcgucacacc




guguuccaucccagcaugaucaagagaucaaaaaaggcucuugccugccccuugugaggug




cuccccauggcagccaggcagagauggguccccggaaggacagagcucccaggaaacagacu




gacacauggaaaucugccacagcagaggcgcgcuggccacaggaggucacugcuucuuugg




ccaauauucugauaucucccugcacuguuuccaaaaagcacaugguagcccuaaggucaaag




ucaacauuugguccccuugcagaggcaacucugaaccgucucugacugaagauucagacug




gugguguacauacgucunacugggugaguugaccccuggccucccacagugcagaaccacu




cucuugaaucacauuaacuuuugagauuuaaaaaaaacccaaacccaacccnncaaaacncca




ganacaccgaaacucuggauccucgaugcuugcugacucucagaauugnuunuucuucuca




nuuaugcaagcnagagcacaccuacuccagcaugauuugucaucuaaagacuugaaaacaaa




acaacaacaacanaaaguuacuuauagucaauggauaagcagaguccgaauuuacacuaauc




aagacagaccuucgaggggucacgauaaguccggaacuuucaaaccuugcuucguaugaau




uguacuaucugaacauaaacugcacuuuuauuuucuaauaccgagggugaauacgguaaau




acaugcuuugaggguagaanccgacggucuguuuggcaccacguuauaaucugcunnuuuu




aacgaguaccaccuuggagggcaggcaaauaaaugcuuuuggguauuuucuccuuuguuuu




ugacaaaugcugcggaugggggaucgggaucggaggggagugcuuuuaaagauaauaaaaa




augagguaaauaauuuuaacuuaugaauuuguuugaauuc





14
X16490
gagauugaaacaauggaagaacuuuccauggcaaacaccauguuugcccucaaucuccuu




aagcagauagaaaaaucaaacucuacccagaacaucuuuaucucuccauggagcaucuca




ucaacauuggccauaguucuccucggugcuggggguaacacugaacagcagauggccaaa




gugcugcaguuuaaugaaauuggcaguuaugguaucaccacaagaaacccagagaacuuc




aguggcugugauuucgcacaacagauacagaaggaaaauuauccuagugcuauuuuacagg




cacaagcaggagauaaaauccauucagccuucuccucucucagcucaacaaucaacaca




ccacagggggauuauuuguuagaaagugcaaacaagcuguuuggagagaagucugcaagau




ucaaagaagaauacauccaacucucuaagaaauauuacucaacagaaccagaagcagug




gacuuccuugaaugugcugaagaagcuagggaaaagauuaauucuugggucaagacucaaa




ccaaaggugaaaucccaaaccugcuacccgaagguucuguagaugaagacaccaagauggug




cuggugaaugcugucuacuucaaaggaaaguggaaaacuccauuugagaagaaacuuaaug




ggcuuuauccuuuccgugugaacucgcaugagagcauaccuguccagaugauguuccucca




ugcaaagcugaacauuggauacauaaaggaccugaagacucagauccuagaacuuccgcaua




cuggaaacaucagcaugcuccuguugcuucccgaugagauugaggacgcauccacuggcuu




ggaauugcuggaaagugaaauaaacuuugccaacuucaacaaguggaucagcaaagacacac




uggaugaagaugauguuguggucuacauucccaaguucaaacuggcacaaagcuacgaacu




caaguccauucuucaaagcaugggcauggaggaugccuucaacaagggcaaggccaacuucu




caggaaugucugagaggaaugaccuuuuucuuucugagguguuccaucaagccagcgugga




ugucaccgaggagggcacuguggcagcuggugggacuggggcaguuaugacaggaagaacu




ggccaugguggcccacaguuuguggccgaucaucccuuucuuuucuuuaucauggacaaaa




uuacccacacgauacuauuuguugguagauucuccucacccuaaaaggggaagaccuauuuc




cacaugagguuuuguagcaugaacuauaagccucagaauugcaucuucaagugccaaaagu




uuaaauacuuucuuacacauuuuuauacuucugcuauacacuaaauauaaccuaaaagcaau




uguauagcagucuucagugcuuacaguauaacucuauuaaugauuuuguuuccuaaaguca




gaugaugucuauuuaguucauccuuauuacugcuuugucuuuauaacuuuaguuuuuaca




guguuauuuauuguuuauauaaugguuguuuuacaaauuguuguccucuguuuaaugaaa




cuguaacacuacagaagcagaaaauuagauaauuuucuauuuaaagaaaaucagccauuuaa




uuuaauaaugaaggaaaaauaugagucuuccauacuuucccaugauauucacccagaaaaaa




uguacuuaacaaaagacauguuauaucucuaucauuauauaucauauguacguaucugcaac




ucaucuauaauuaggacuacaucauaaguaagcaugcuuacuuacacacugcuaucuguug




uauaaaacuuagcaauccuuauuuguuaguuaucuuucuaucacuguaacaaaauaccuga




gauaauaaaguucaaagauuuauuuugaaaaaaaaaaaa





15
AW120868
uuuuuuuuuuuuuuunuaagaauuaacuuuuauuuuugcuuaguuuuauuaaaaaaauaa




auaugucauaaagcuuuuguuuccuuuagggagaaaaaaaaggaacaaguuccauaaaauca




aacaagcaaugguaacaugucuuaacuugaaaacaacuggggucacugguuuacaaguuaua




acugaaugaaugacugccacaguugcccauuuccuccugccaauggcagcaaacaacaggau




caacuagggcaaaauaaauaauuguguggaagcccuga





16
C78850
aacuaaacuuccuuguaacuuuugagaacucagcucugguacuuuuucaugccuugcaaaa




uggcguuanugcagcuagcuugcuaanccuuaugguggggucuuucauuccccccucuuuc




uggaaacugnauaaaaucauuuauucacgugauucuauuucuucuggaucuauugauuuga




guuggugauacuguugggucanaaccagggccuguu





17
D67076
Sequence below.










gcagcuccgagcuaggugcuaucgcaaggccagagcgcacagcccggcggagagagcagauccuugcucagaucgagucaa


aucgggccaaggcggaggacgaagaguccaggcuccuauucuggacuuguuccccagcuccgggggcgcuucuagguccu


gcagcagccagcagugcggagccaccaacucggugcuggaaugaaaaaauucccgcgcgccagugcagaaucuuucuaagu


gacccggagcuucgggugcuagcucugcacgaacuuucccaucaaagugaucgugaauuuuaagcaucaggagcaggccag


cgaagcucuacgcgucuaaacgucuauccagaccaagaguucucugcggugcagggugcggugccaugcagccaaaagucc


cuuuuggggucacgcaagcagaagcccugcuccgacaugggggacguccagcgggcagcgagaucucggggcucucugucc


gcacacaugcuguugcugcuccucgcuuccauaacaaugcugcuaugugcgcggggcgcacacgggcgccccacggaggaa


gaugaggagcugguccugcccucgcuggagcgcgccccgggccacgauuccaccaccacacgccuucgucuggacgccuuu


ggccagcagcuacaucugaaguugcagccggacagcgguuucuuggcgccuggcuucacccugcagacuguggggcgcag


ucccggguccgaggcacaacaucuggaccccaccggggaccuggcucacugcuucuacucuggcacggugaacggugaucc


cggcucugccgcagcccucagccucugugaaggugugcguggugccuucuaccuacaaggagaggaguucuucauucagcc


agcgccuggaguggccaccgagcgccuggccccugccgugcccgaggaggagucauccgcacggccgcaguuccacauccu


gaggcgaaggcggcggggcaguggcggcgccaagugcggcgucauggacgacgagacccugccaaccagcgacucgcgacc


cgagagccagaacacccggaaccaguggccugugcgggaccccacgccucaggacgcgggaaagccaucaggaccaggaagc


auaaggaagaagcgauuuguguccagcccccguuauguggaaaccaugcucguagcugaccaguccauggccgacuuccac


ggcagcggucuaaagcauuaccuucuaacccuguucucgguggcagccagguuuuacaagcaucccagcauuaggaauuca


auuagccuggugguggugaagaucuuggucauauacgaggagcagaagggaccagaaguuaccuccaaugcagcucucacc


cuucggaauuucugcagcuggcagaaacaacacaacagccccagugaccgggauccagagcacuaugacacugcaauucugu


ucaccagacaggauuuauguggcucccacacgugugacacucucggaauggcagauguuggaaccguaugugaccccagca


ggagcugcucagucauagaagaugaugguuugcaagccgccuucaccacagcccaugaauugggccauguguuuaacaugc


cgcacgaugaugcuaagcacugugccagcuugaauggugugaguggcgauucucaucugauggccucgaugcucuccagc


uuagaccauagccagcccuggucaccuugcagugccuacauggucacguccuuccuagauaauggacacggggaauguuug


auggacaagccccagaauccaaucaagcucccuucugaucuucccgguaccuuguacgaugccaaccgccagugucaguuua


cauucggagaggaauccaagcacugcccugaugcagccagcacauguacuacccuguggugcacuggcaccuccgguggcu


uacuggugugccaaacaaaacacuucccuugggcagauggcaccagcuguggagaagggaaguggugugucaguggcaag


ugcgugaacaagacagacaugaagcauuuugcuacuccuguucauggaagcuggggaccauggggaccguggggagacug


cucaagaaccuguggugguggaguucaauacacaaugagagaaugugacaacccagucccaaagaacggagggaaguacug


ugaaggcaaacgaguccgcuacagguccuguaacaucgaggacuguccagacaauaacggaaaaacguucagagaggagcag


ugcgaggcgcacaaugaguuuuccaaagcuuccuuugggaaugagcccacuguagaguggacacccaaguacgccggcguc


ucgccaaaggacaggugcaagcucaccugugaagccaaaggcauuggcuacuuuuucgucuuacagcccaagguuguagau


ggcacucccuguaguccagacucuaccucugucugugugcaagggcagugugugaaagcuggcugugaucgcaucauaga


cuccaaaaagaaguuugauaaguguggcguuuguggaggaaacgguuccacaugcaagaagaugucaggaauagucacuag


uacaagaccuggguaucaugacauugucacaauuccugcuggagccaccaacauugaagugaaacaucggaaucaaagggg


guccagaaacaauggcagcuuucuggcuauuagagccgcugaugguaccuauauucugaauggaaacuucacucuguccac


acuagagcaagaccucaccuacaaagguacugucuuaagguacagugguuccucggcugcgcuggaaagaauccgcagcuu


uaguccacucaaagaacccuuaaccauccagguucuuaugguaggccaugcucuccgacccaaaauuaaauucaccuacuuu


augaagaagaagacagagucauucaacgccauucccacauuuucugagugggugauugaagaguggggggagugcuccaag


acaugcggcucagguuggcagagaagaguagugcagugcagagacauuaacggacacccugcuuccgaaugugcaaaggaa


gugaagccagccaguaccagaccuugugcagaccuuccuugcccacacuggcaggugggggauuggucaccauguuccaaa


acuugcgggaaggguuacaagaagagaaccuugaaaugugugucccacgaugggggcguguuaucaaaugagagcuguga


uccuuugaagaagccaaagcauuacauugacuuuugcacacugacacagugcaguuaagaggcguuagaggacaagguagc


guggggaggggcugauacacugagugcaagaguacuggagggauccagugagucaaaccaguaagcagugagguguggca


aggagguguguguaggggauacauagcaaaggagguagaucaggacacuacccugccaguuacauucugauaagguaguu


aaugaggcacaguagcaucugaaagaccauacagagcacuaaggagccccaaagcacuauuaguaucucuuuucuuauaucu


aucgcccaaauaauuuucagagucuggcagaagcccuguugcacuguacuaacuagauacuucuuaucacaaagauuggga


aaggcaaagcagaaagaugguaagacuggguuucaaacaaggcuugguuucaaucacuggaggcaaggaggaggggacaaa


caagaucauuauucgaagucgcugguugcugugguuuuacggaagguugaugcaucauuccuaucaacagugaaaaguuc


agcuuguucaacgugacagaaaggcucaucuccgugaaagagcuccugauuucuucuuacaccaucucaguucuuaacuau


aguucauguugagguagaaacaauucaucuauuuauaaaauguacauuggaaaaaaaaagugaaguuuaugagguacacau


aaaaacugaaggaaacaaugagcaacaugccuccugcuuugcuuccuccugagguaaaccugccuggggauugagguuguu


uaagauuauccauggcucacaagaggcaguaaaauaauacauguugugccagaguuagaaugggguauagagaucaggguc


ccaugagauggggaacauggugaucacucaucucacaugggaggcugcugcag












18
M61007
ccgcgggcccgcguucaugcaccgccugcuggccugggacgcagcaugccucccgccgcc




gcccgccgccuuuagacccauggaaguggccaacuucuacuacgagcccgacugccuggc




cuacggggccaaggcggcccgcgccgcgccgcgcgcccccgccgccgagccggccauugg




cgagcacgagcgcgccaucgacuucagccccuaccuggagccgcucgcgcccgccgcgga




cuucgccgcgcccgcgcccgcgcaccacgacuuccucuccgaccucuucgccgacgacua




cggcgccaagccgagcaagaagccggccgacuacgguuacgugagccucggccgcgcggg




cgccaaggccgcgccgcccgccugcuuuccgccgccgccucccgccgcgcucaaggcgga




gccgggcuucgaacccgcggacugcaagcgcgcggacgacgcgcccgccauggcggccgg




uuucccguucgcccugcgcgccuaccugggcuaccaggcgacgccgagcggcagcagcgg




cagccuguccacgucgucgucguccagcccgcccggcacgccgagccccgccgacgccaa




ggccgcgcccgccgccugcuucgcggggccgccggccgcgcccgccaaggccaaggccaa




gaagacgguggacaagcugagcgacgaguacaagaugcggcgcgagcgcaacaacaucgc




ggugcgcaagagccgcgacaaggccaagaugcgcaaccuggagacgcagcacaaggugcu




ggagcugacggcggagaacgagcggcugcagaagaagguggagcagcugucgcgagagcu




cagcacccugcggaacuuguucaagcagcugcccgagccgcugcuggccucggcgggcca




cugcuagcgcggcgcgguggcguggggggcgccgcggccaccgugcgcccugccccgcgc




gcuccggccccgcgcgcgcgcccggaccaccgugcgugcccugcgcgcaccugcaccugc




accgaggggacaccgcgggcacaccgcgggcacgcgcggcgcacgcaccugcacagcgca




ccggguuucgggacuugaugcaauccggaucaaacguggcugagcgcguguggacacggg




acuacgcaacacacguguaacugucuagccgggcccugaguaaucaccuuaaagauguuc




cugcgggguuguugauguuuuugguuuuguuuuuguuuuuuguuuuguuuuguuuuuu




uuuuuggucuuauuauuuuuuuuguauuauauaaaaaaguucuauuucuaugagaaaaga




gg




cguauguauauuuugagaaccuuuuccguuucgagcauuaaagugaagacauuuuaauaa




acuuuuuuggagaauguuuaaaagccaaaaaaaaaa





19
C85523
aaaauguagaaggcaagauuuaauaaggcagcaacaugaaagcacacagaccagagcucu




ggggucgaaauaaagcagcaacauggaagcacacagagcucuggggucgaaacucauaca




ccuuagcacaggguagaggagucucgacggucanccagaauuuuucacaggcuuauauag




uaaaacucaaagggggagaacugggcagggaaaguacaaguuuacaucacuagggaguuc




ugccaaaggacaanggguucunucagaggaaucuacguaacuaaggngucauguccuauc




aaggnaucuacguaacuaaggagucauguccuaucauuuggcaauguacccggnucuuuu




gagguuguuccggagggncuuauucucaaaauguuuuucagauuggaagggguggguunc




cgguaaaaaguucuguuuucaaagaggcnguaauuuucuauucuucauuccccauucucc




uguaaguauucnnaucuuagaauuucagaaguccauauucncuauguggggaauaacugg




cuuuaacccnaucuuuaaaauggggg





20
AW122030
uuuuuuuuuuuuuuuuuaugaaacaguuuuguucagcccaugacuuugugcaugacuguc




guccguucuagucaccugugcucuccaucuacugccuuuuaaagcugcgucaugagaagg




aucuacacguuccaccaugacucucguuucuugccacaaguagaagaaaugguugauucu




uugcuuuucgguuaggccguuaaacaaaacucagucacaccccugccuuccacccucaaa




cugugaucacguggcuguucuuguaguunaaccagggcaacacuauauauuccaggucua




uacauugcugaggucuuuuucugguuguucauguaucaguguuuucaaccucgugccg





21
U57524
Sequence below.










gcggccgcggcuccagaccccggccuugcgcacccuccccccaccuccagcccgcgccucccccccccccacgcauggcucac


caccccucggguuucccugucaucccucagguuccugcacuuggcaaucauccacgaagagaagccgcugaccauggaagu


cauuggucaggugaagggagaccuggccuuccucaacuuccagaacaaccugcagcaggugcgcugcuugcuugccccgcg


gugccccucuuugaccccuugguggagucagauguagcacggucgcccccaaagcguuucuaaauuaauagucacuuaguu


cuuaucugccuuggcuuuuuugcauucaaaucagccaacgucuuagaaccagaagaaaaaucccuugguuuuagugagguc


uuuaugacccaccuagggccuccuguuugccugaucuccuaagagacaaaugggaggaucagauuccauagcgggaggugu


cugggguucaggaaacucaagacuauggguuugcuccauggcuuaucccuuucuguuuccucuuccauuuguagacucca


cuccacuuggcugugaucaccaaccagccaggaauugcugaggcacuucugaaagcuggcugugauccugagcuccgagac


uuucgaggaaauaccccucuacaucuugccugugagcagggcugccuggccaguguagcagucuugacgcagaccugcaca


ccccagcaucuccacuccguccugcaggccaccaacuacaaugguaggucugccaguccauccaaggaugcagaggagggag


agagauggggccacuugagucuuaaacuccgaacguauacaaaguucagacacugugaucuuuuuaaaaaguuuucuccuc


gaugccuauaugauauucacucagaacccagauucugaguucuucaaaacugaugauguuugugguuguccucaagacaau


agacaugaguugugugaggauugaaacacguaguacaguuuuugucuuccuccuccaggccacacgugucugcaccuagcc


ucuacucacggcuaccuggccaucguggagcacuuggugacuuugggugcugaugucaacgcucaggugaguacaucucc


cuuccaccuaaucucuguugggcuggcucugauggugagcagguuuccagaugcagccguaaacuaacgccugauugcuu


uugguuucaggagcccugcaauggccggacagcccuccaccuugcgguggaccugcagaauccugaccugguuucgcucuu


guugaaauguggggcugaugucaacaggguaaccuaccaaggcuacucccccuaccagcuuaccuggggccgcccaaguac


ccggauacagcagcagcugggccagcugacccuggaaaaucuccagaugcuacccgagagcgaggaugaggagagcuauga


cacggagucagaauucacagaggaugaggugaguguuccuccccucagcacgcugacggcuguucuagggcugcuuugga


ucagagggauuucaguuguuuaacuucucagacucggcuugcaaagcaggaucccaagaauuugucucugguuuguuuua


agagcuuacccuuuugguugaggaaugagggaauucuagaaauugaacccaggccuuagcacauggugauaagcacacguu


caaccauuaagcuccacccccucaauagcuuagacuuuuuuuuuuuuuaaggaaagaauagguaagggaaacuccuacagc


cuggugcccuuguucuauuuggguuaaggagaaaaagagcccaagaauaggaguuauuucagcagcagcucuccccuuauc


ccaaugucuuggugaaguucuaggaauuuaauaugucuuuuuccccucucuuguuuuagcugcccuaugaugacugugug


uuuggaggccagcgucugacauuauaaguggaaaguggcaaaaaagaauguggacuuguauauuuguacaaauagaguuu


uauuuuucuaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaguauacuuagcaccacaccacacagcgccuagacccaggc


auuuuacuggggugauucggcuguugucuuugugaaauccgggg












22
U05809
cucucggucacugccggucgcuuccugagccgcugcuggcucugugucucuguccucagc




guucucuuccucguccucguccuaccacgccauggaagguuaccauaagccagaucagca




gaagcuccaggcccugaaggacacagccaaucgccugcgcaucagcuccauccaggccac




caccgcggcaggcucaggccaccccacaucaugcugcagcgcugccgagaucauggcugu




ccuguuuuuccauaccaugcgcuacaaggcccuggauccccgaaacccucacaaugaucg




cuuugugcucucuaagggccaugcagcucccauuuuauaugcagucugggcugaagcugg




cuuccugcccgaggccgagcugcugaaccugaggaagaucagcucugacuuggacgggca




uccugucccgaaacaagccuucaccgauguggccacuggcucccugggccagggccuggg




agcugcuugcgggauggcauacacaggcaaauacuuugacaaagccagcuaccgagucua




uugcaugcugggagacggggaggucuccgagggcuccgucugggaggccauggccuuugc




uggaauuuacaagcuggacaaccucguugccauuuuugacaucaaccgccugggccagag




cgacccagccccgcugcagcaccagguggacaucuaccagaagcgcugugaggccuuugg




cuggcacaccaucaucguggacggacacagcguggaggagcugugcaaggccuuugguca




ggccaagcaccaaccaacagccaucaucgccaagaccuucaagggccgagggaucacagg




gauugaagacaaggaggcguggcacgggaagccccuccccaaaaacauggccgagcagau




uauccaggagauuuacagccagguucagagcaaaaagaagauccuggccacgcccccuca




ggaggaugccccauccguggacauugcuaacauccgaaugccuacgccacccagcuacaa




agugggggacaagauagccacccggaaggccuauggacuggcccucgcuaagcugggcca




cgccagugaccguaucauugcccuggauggagacaccaagaauuccaccuucucggagcu




cuucaaaaaggagcacccagaccgguucauugagugcuacauugccgagcaaaacauggu




gagcauugccgugggcugugccacacgugaccggacagugcccuucugcaguacuuucgc




ggccuucuucacacgggccuucgaccagauucgcauggccgccaucucugagagcaacau




caaccucuguggcucccacugugguguguccauuggggaagacgggcccucucagauggc




ccucgaagaccuggccauguuccggucaguccccauguccaccgucuuuuacccaagcga




uggaguugcaacagagaaggcaguggaguuagcagccaacacaaagggcauuugcuucau




ccggaccagccgcccagagaaugccauuauuuauagcaacaaugaggauuuccaggucgg




ccaagccaaggugguccugaagagcaaggaugaccaagugacagugaucggggcuggugu




aacucugcaugaggccuuggcugcugcagagagucuaaagaaagauaagaucagcauccg




ggugcuggaucccuucacuaucaagccccuggacaggaaacucauccuagacucugcccg




agcaaccaaaggcaggauccucaccguggaggaccacuacuacgaagguggcauaggaga




ggcagugucugcugccguagugggugaaccuggagugacggucacucgccuggcugucag




ccaaguaccacgaaguggcaagccagcugagcuacugaagauguucgguauugacaagga




cgccauugugcaagcugugaaaggccuugucaccaagggcuagggagggcaugggaugcu




gggugggugaacuacacauuccagggagguucuggcagagguggcgaagguguacugagu




ggggagguaaauauauguuuug





23
AW212475
uuaacggugucauaaauaaguaauauaacuuuauuaaaaugaaaagacaauauucaaaau




aaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggagaucagug




cauuuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuuuaaauag




cucaaauaaugucauucagcaguuuaaacugaacagcuuguugggacaug





24
V00835
ugaguucucguaaacuccagagcagcgauaggccguaauaucggggaaagcacuauaggg




acaugauguuccacacgucacaugggucguccuauccgagccagucgugccaaaggggcg




gucccgcugugcacacuggcgcuccagggagcucugcacuccgcccgaaaagugcgcucg




gcucugccaggacgcggggcgcgugacuaugcgugggcuggagcaaccgccugcugggug




caaacccuuugcgcccggacucguccaacgacuauaaagagggcaggcuguccucuaagc




gucaccacgacuucaacguccugaguaccuucuccucacuuacuccguagcuccagcuuc




accagaucucggaauggaccccaacugcuccugcuccaccgguaagacucccgauccuug




gucuuuagaauaccaaguugggaccgcagagcggaauccccgaguuguagaggcuuggcg




ggaauaggcaccuuuaguuggcgauucauuccgguucuuucuagaauccgcucuugcaaa




agccuucauuaguuacgaguauugucgaacggguccuuuggcgggguuggggcuaggauu




uagacgcgcaaauguccgguuccugaucacccaguuaguggggacaucuggguugagucc




caggcauuacuaaacuuacugugaauugcuugaauuaagaaagaggugaaggaccuuuau




gucuugggacucaaagacauaaucccugacuuaaccugugaggagaaaaguggggcuagg




cucccugcagcuccgaggaggacuuagugaacugagccgggacucgugguguuggccacu




gcuguaaugcugccucccucaugcugucuucuuucuccucccaggcggcuccugcacuug




caccagcuccugcgccugcaagaacugcaagugcaccuccugcaagaagagugaguuggg




acaccuuggguggcggcuaaggcuaggggcggggaacuccuacaaaacuggcucugagaa




auguccuuugcuucccggaggccauuguauugucucggggacagaacuauacagagaacu




auuuaaaaaaaccgaggucuucucuguuggggacaggaagcagaggucuucagccaggcu




gccucuuccuccuucuucuaggcugcugcuccugcugucccgugggcugcuccaaaugug




cccagggcugugucugcaaaggcgccgcggacaagugcacgugcugugccugaugugacg




aacagcgcugccaccacguguaaauaguaucggaccaacccagcgucuuccuauacaguu




ccacccuguuuacuaaacccccguuuucuaccgaguacguuaauaauaaaagccuguuug




agucuaacucugguuucuuggugugguuuggcaauaagaaacuggggugacuugauaguc




uggggaucugguuuuggacccccucgugccuuuaccuccgcccucuggcccucacagagg




gguaaugucuuuggguaaagccaagcuauaucccauaagcuuccucauggaaaacagcug





25
AV374868
gcggcacgaugugucuucggguggcuuuuuuuuuuuuguuuugaauaauguuuacaauuu




cccucaaucacuuuuauagaaauccaccuccaggccccccccuuuccccacuuaggccuu




cgaggcugucugaagaugcuugagaaacucaaccaaaucccaguucaauucagacuuugc




acauauauuuauauuuauaaucagaaaagaaacauuucaguaauuuauaauaaaagagca




cuauuuuuuaacg





26
M21285
See above (same Accession Number).





27
U74683
acugccaucgagugguguuccaguugaacuugcucucucugccaucugcuccgcgggcgc




cgucagcaugggucccuggacccacuccuugcgcgccguccugcugcuggugcuuuuggg




agucugcaccgugcgcuccgacacuccugccaacugcaccuacccugaucugcugggcac




cuggguguuccaggugggcccuagaaguucccgaagcgacauuaacugcucggugaugga




agcaacagaagaaaagguagugguacaccuuaagaaguuggauacugccuacgacgagcu




gggcaauuccgggcauuuuacccucauuuacaaccaaggcuucgagauuguguugaauga




cuacaaaugguuugcguuuuucaaguaugaagucagaggccacacagcuaucaguuacug




ccaugagaccaugacuggguggguccaugaugugcugggccggaacugggcuugcuuugu




uggcaagaagguggaaagucacauugagaagguuaauaugaaugcagcacaucuuggagg




ucuccaggaaagauauucugaaagacucuacacucacaaccacaacuuugugaaggccau




caauaccguucagaagucuuggacugcaacugcauauaaggaauaugagaaaaugagccu




gcgagaucugauaaggagaaguggccacagccaaaggaucccaaggcccaaaccugcccc




gaugacugaugaaauacagcaacaaauuuuaaauuugccagaaucuugggacuggagaaa




cguccaaggcgucaauuauguuagcccuguucgaaaccaagaaucuuguggaagcugcua




cucauuugccucuauggguaugcuagaagcaagaauucguauauuaaccaacaauucuca




gacaccaauccugaguccucaggagguuguaucuugcagccccuaugcccaagguuguga




ugguggauucccauaccucauugcagggaaguaugcccaagauuuuggggugguggaaga




aagcugcuuucccuacacagccaaagauucuccaugcaaaccaagggagaauugccuccg




uuacuauucuucugacuacuacuaugugggugguuucuaugguggcugcaaugaagcccu




gaugaagcuugagcuggucaaacauggacccauggcaguugccuuugaaguccacgauga




cuuccuacacuaccacaguggaaucuaucaccacacugggcugagugacccuuucaaccc




cuucgagcugacaaaucaugcuguuuugcuugugggcuauggaagagauccaguuacugg




gauagaauacuggauuauaaagaacagcuggggcucuaacuggggggagaguggcuacuu




ccguauccgcagaggaacugaugaaugugcaauugagaguauagccguggcggccauacc




gauuccuaaauuauaggacauagcucccaguguuacauacgggucuuuaucacucacaga




gugauuuagucacaugcugaagacuuuuucagagcaauaucagaagcuuaccacuaagca




ucuuuaaagaauuuugucuuugaacuuaaaaccauccuugauuuuuuucuuuuaauaucu




uccccaucaacuacugaacuacuuuucuuuuuaaaguacuugguuaaguaauacuuuuau




gagcagugguucaguuguccaauauuuuuugcaggucaucuacaaugcaaccagauguuu




caguucuaaaaaucuauguaaaaguacaagcucguuuuuaaauuauguaagucacaugaa




aacauggcaaaaaaauuaguuaaauuuuuuacaaagaguuuuaaauaaauguuuauguaa




ucaguaccauagucuuucuauguguguuuacaagaauuuuugucaccuacuucuucccuu




agaagcauuuaugcuccauggacguacuucuuuauggagaaaaaaaaaa





28
X61800
gagcucgaucccuguuccgccuuugcuaugucugaaggcguccugcuuugcgcgugucgg




ggccaaauccagauuuucauuucgcuccaggcuuggacggcuaaguagguccaaaccgca




caaacaggaaggagggaaggcaaggagugcgggcagagggcgggucguucccagcagcac




cccagucccuccccgcuccgucuccgacccacuggggccggggcgggcgugcgcgucagc




uggggcuagaaaaggcggcgguccggcccggcgaggugacagccaacuuggacgccaggu




ccggccgacgccgccaugagcgccgcgcuuuucagccuggacagcccggugcgcggcaca




cccuggcccacagaacccgcggccuucuacgagccaggcaggguggacaagcccggccga




gggcccgagccaggggaacugggggagcugggcuccacgacuccugccauguacgacgac




gagagcgccaucgacuucagcgccuacauugacuccauggccgccgugcccacccuagag




cugugccacgacgaacucuucgccgaccucuucaacagcaaccacaaagcggccggcgcg




ggcggccuggagcugcugcagggcggcccuacgcgacccccggguguggggucugucgcu




agggggccgcucaagcgcgaacccgacuggggcgacggcgacgcgccgggcucccugcug




ccggcgcaaguggcggugugcgcgcagacaguggugagcuuggcggccgcggcucagccc




acuccacccacuucgccggagccuccucgaggcagcccggggccgagccucgcgcccggc




acaguccgagaaaagggcgcgggcaagagggguccggaccgcggcagcccggaguaccgg




cagcggcgcgagcgcaacaacaucgcugugcgcaagagccgcgacaaggccaagcgccgc




aaccaggagaugcagcagaagcugguggaguugucggccgagaacgagaagcugcaucag




cgcguggagcagcucacccgggaccuggcuggccuccggcaguucuucaaaaaacugccc




agcccgccuuuccugccgcccaccggcgccgacugccgguaacgcgcggcgugggccuuu




gagacucugaacgaccuauaccucagaccccgacagcggggagcagacgccgcccgaauc




gcuaguuucuuugggaccugcgagcgacaggaagcugcagcuugggcacuggacugcgag




agaagcuauauuaaucuuuccccuuaaauuauuuuuuauaaugguagcauuuucuacguc




uuauuaccauugcagcuaagguacauuuguagaaaagacauuuccgacagacuuuuguag




auaagaggaagagacugcgcaugcuuuuuauauucauuuuuacaguauuuguaagaauaa




gaauaagaauaaagaagcauuuaaaucgcaaaaaaaaa





29
U20735
Sequence below.










uugaggguggccaggccagcguaggaggccagcguaggauccugcugggagcggggaacugagggaagcgacgccgagaa


agcaggcguaccacggagggagagaaaagcuccggaagcccagcagcgccuuuacgcacagcugccaacuggccgcugccga


ccgucuccagcucccgaggacgcgcgaccggacaccggguccugccacagccgaggacagcucgccgcucgccgcagcgagc


ccggggcggcccuucagggggaccuuucccagaucgcccaggccgcccggaugugcacgaaaauggaacagccuuucuauc


acgacgacucuuacgcagcggcgggauacggucggagcccuggcagccugucucuacacgacuacaaacuccugaaacccac


cuuggcgcucaaccuggcggaucccuaucggggucucaaggguccuggggcgcgggguccaggcccggagggcagugggg


caggcagcuacuuuucgggucagggaucagacacaggcgcaucucugaagcuagccuccacggaacuggagcgcuugaucg


uccccaacagcaacggcgugaucacgacgacgcccacgccuccgggacaguacuuuuacccccguggggguggcagcggug


gagguacagggggcggcgucaccgaggagcaggagggcuuugcggacgguuuugucaaagcccuggacgaccugcacaag


augaaccacgugacgccccccaacgugucccugggcgccagcggggguccccaggccggcccagggggcgucuaugcuggu


ccggagccgccucccgucuacaccaaccucagcaguuacucuccagccucugcacccucuggaggcuccgggaccgccgugc


ggacugggagcucauacccgacggccaccaucagcuaccucccacaugcaccacccuuugcgggcggccacccggcacagcu


ggguuugagucguggcgcuuccgccuuuaaagaggaaccgcagaccguaccggaggcacgcagccgcgacgccacgccgcc


ugugucccccaucaacauggaagaccaggagcgcaucaaaguggagcgaaagcggcugcggaacaggcuggcggccaccaa


gugccggaagcggaagcuggagcgcaucgcgcgccuggaggacaaggugaagacacucaaggcugagaacgcggggcuguc


gagugcugccggucuccuaagggagcaaguggcgcagcucaagcagaaggucaugacccaugucagcaacggcugccaguu


gcugcuaggggucaagggacacgccuucugagagccucccuugccccauacggacacccccagccuugaaggcugggcgcc


ugccccccacuggggugaggggggcaggcgaugggcacccgccaaaaggccuggggcgcagcucacacacuggacuccggc


ccgcccgccugcgcccaguccuuccaccucgagguuuacauggcccccuuccagcguauuuuguauguuuuuuuuuucug


caaagagacugaauucauauugaauauaauauauuuguguauuuaacaggagggagaagggggcugucgcggcggagcug


gccgccgcuugguacucagcugcggggauacuagggagggaccuccgcccccugcccucccccucugcauaguacugugga


gaagaaacacgacuucgugucuaaagucuauuuuaagauguguuuguguguguguguuugacuuuuuauugaaucuauu


uaagua












30
U19118
Sequence below










gaauucggcacgagcagcgagacgccgcgcacggugcuuccccaguggagccaaucggcuaacccgcgcuccggcagaguc


cuuggcgcucgcccgccggcgggacagaccacccgccucuggccgcucucuggacccuggccgccccgagcgaagacugga


gcaaaaugaugcuucaacauccaggccaggucucugccucagaagucagugcgaccgccauuguccccugccucucaccucc


ugggucacugguauuugaggauuuugcuaaccugacacccuuugucaaggaagagcugagauucgccauccagaauaaaca


ccucugccaucggauguccucugcgcuggagucaguuaccgucaacaacagaccccuggagaugucagucaccaagucuga


ggcggccccugaagaagaugagaggaaaaggaggcggcgagaaagaaauaaaauugcugcugccaagugucgaaacaagaa


aaaggagaagacagagugccugcagaaagagucagagaaacuggagagugugaaugcugagcugaaggcccagauugagga


gcugaagaaugagaaacagcauuugauauacaugcucaaccugcaccggcccaccuguaucguccgggcucagaauggacg


gacaccggaagacgagaggaaccucuuuauccaacagauaaaagaaggaacauugcagagcuaagcagagguggcacggagg


caauuggggaguucuuacugaauccuccuuuuccaccccacacccugaagccauuggaaaacuggcuuccugugcacuucu


agaaucccagcagccaagagccguuggggcaggagggccuguggugaccuacugcauugacccacucugcccccgagugaa


ccguggagcaggcaggagcauccuuugucucaccaauuccaggauuuaggccuuaucaucccggccagucucagaugaccu


agcuggccccaggcugggguccuaugcaaagcaggaucccacuaaugggauucaggcagaagugucuaccuugauaggugg


ggugggaccacauccuccacuguggcugacaacgcccuuccaagggaauauggaaugagaacauucauuauugagguuguc


caauggccaggguaugcuuucuagaaaauaugcuguucugucccagaaugacugugcauaggguauccguuucagagccu


gguguugugcuauuuagauguuugucuugcacaacauuggcaugauuuuuccgggaguuucaucagaucugauuucuga


gagucuggggaucugccaugguggaaagugccccucaaaagcauuuguguggccacaugaacuggcuggcaccaggggag


ugaaacuggcugaugaccagcugagccacuuugugccaacagaggauggacgacaccuuucccuguacccacugcagagga


agaacccugggcacagcagcuuuguccuuggcuacaaacuguuacaacgucacacaaugaaggcacaaaguccaacuuucaa


aggguguaggacuccauacucagugacagggcaggaagagccaaagauaaccacagccacagccuguggagaccaggguug


gaagccaggugcagggccaggcaucugcauugugggauguuaauggcacuuuugucuuguagcuauuuugagauguggu


ccagagcauuucagcugggagaucucccucuggccaccaggacucuggcuacuguuaaaauccugauguuucuguggaauc


cucaguguuuaaucccacucaauaguaucauuacaguuuucuguaagagaaaauauuacuuauuuaucccaguauuccuag


ccugucaacauaauaaauaucggaacaaaaccuggua












31
AW049031
uuuuuuuuuuuuuuuuugcugauaagaauucuuuuuauguuauucgaauaaaaaauaca




uucauacagaaauauaacaaucucgcaaaaaacaauuucaaauaaaaucuuguaaaacaaa




auuuuacaaaaaucuuacaaagauucuuuagauaacagggugcuucaaaaaaaaagaaau




aaagaaauuucacuaauagaaauuuuuuuuuuuaauuucaagcaaaaguuccugcuugau




ugaggcucaguugucaccugaccagaauggacugcuuaguauuaaaguuacagcaucgac




acggacggcacccagccccagccaguccagcaacgucgcuguguuucauaagugagacgc




gccagcacaaguuuccucucucuucuguuuaccuucuuacuuaauggaauugcuauggau




aagcacacagcagggccaaaaaaggaguuuuccaaaauccagcaaaucaagug





32
M93275
uaguggugaucuggaccgugcggacuugcucgucccucagcucuccuguuaggcgucuc




u




uuucuccaggaggaaaaaauggcagcagcaguaguggauccgcaacagagcguggugaug




agaguggccaaccugcccuuggugagcucuaccuacgaccuuguguccuccgcuuauguc




aguacaaaggaucaguacccguauuugagauccgugugugagauggccgagaagggcgug




aagaccgugaccucugcggccaugacaagugcccugcccaucauccagaagcuggagcca




caaauugcgguugccaauaccuaugccugcaaggggcuagacaggauggaggaaagacug




ccuauucugaaccagccaacguccgagauuguugccagugccagaggugccguaacuggg




gcgaaggauguggugacgacuaccauggcuggagccaaggauucuguagccagcacaguc




ucaggggugguggauaagaccaaaggagcagugacuggcagcguggaaaggaccaagucu




guggucaauggcagcaucaauacaguuuuggggauggugcaguucaugaacaguggagu




a




gauaaugccaucaccaagucggagaugcugguagaccaguacuucccucucacucaggag




gagcuggagauggaagcaaaaaagguggaaggauuugauaugguucagaagccgagcaac




uaugaacggcuggagucccugucuaccaagcucugcucucgggcuuaucaccaggcucuc




agcaggguuaaagaggccaaacaaaagagccaggagaccauuucucagcuccacuccacu




guccaccugauugaauucgccaggaagaauaugcacagugccaaccagaaaauucagggu




gcucaggauaagcucuaugucucguggguggaguggaagagaagcaucggcuacgacgac




accgaugagucccacuguguugagcacaucgagucacguacucuggcuaucgcccgcaac




cugacccagcagcuccagacuacaugccagacuguccuggucaacgcccaaggguuacca




cagaacauucaagaucaggccaaacacuugggggugauggcaggcgacaucuacuccgua




uuccgcaaugcugccuccuuuaaggaaguguccgauggcguccucacaucuagcaagggg




cagcugcagaaaaugaaggaauccuuagaugaaguuauggauuacuuuguuaacaacacg




ccucucaacuggcugguaggucccuuuuauccucagucuaccgaggugaacaaggccagc




cugaagguccagcagucugaggucaaagcucaguaaaccccuccuugucaccagagcaug




auguugcuggccagaugaccccuuuugcuguauugaaauuaacuugguagauggcuuua




g




cuuagaaaagcagcuucuuagaaccaagggccucauuauggucacucacagcucaguuau




ggucuugccccagcuggcccuggcacaggaguucucuuaccuggcuggugaguggccug




u




guuagucuugugaggaccuggaggaaccuaaaagcucagaugcacuuacagucuugucug




uggccuuuguauuguuauuggcuguaaacgucugucuggaccgaauaaagauucacgug




a





33
AB000713
ggcacgagggagcugcaguguucgcgcuugguagcuggugcaucggacucagcuggcuu




u




gugucccugaggcucaccgaaaaacacuuucucagcccucugacuccagagagagagaga




gagagguacuuuuuguggucaccgacuuugaccccugcagaggcugagcgauggcgucu




a




ugggacuacagguccugggaaucuccuuggcaguccugggcuggcuggggaucauccug




a




guugugcgcuccccauguggcgggugaccgccuucaucggcagcaacaucgucacggcac




agaccagcugggagggccucuggaugaacugcguggugcagagcacaggucagaugcagu




gcaagauguacgacucgaugcucgcccugccgcaggaccugcaggccgcccgagcccuua




uggucaucagcaucaucgugggugcucuggggaugcuucucucagugguagggggcaag




u




gcaccaacugcauggaggacgagaccgucaaggccaagaucaugaucaccgccggagccg




uguucaucguggcaagcaugcugauuauggugcccguguccuggaccgcucacaacguca




uccgcgacuucuacaacccuaugguggcuuccgggcagaagagggaaaugggggccucgc




uuuacgucggcugggcggccuccgggcugcugcuccugggaggaggccuccucugcugc




a




guugcccaccucguagcaacgacaagcccuacucggccaaguacuccgccgcccgcucug




uccccgccagcaacuauguguaaggugggccacucuguccacauugccuuuguuauuuuu




uuucggauugagcucauaacagccuguggccccucacauucuccaggaccugcccugcua




ugggccacuaacugcuugcuggggacaggcaaacccggacugugcaaaguuacuagcccg




uagcucuugggcugcuccacauggcuccuuacggccggcaagaauggauguaaaaauauc




uugcugcuuacauccaaauugcgguggauaugggcugaaggcagaagcagcugggaagg




g




caguagaggcgcaagcuggguccugcuggccgggguagcucagcugugacuuuggacuc




g




gaguggauguccucauguuagcaaacguccacuguccuuucucuaucccccucacucagc




cuacacguuacuccagcgcuacucuugccauuacgccccguguuuccgagcacagcuggu




ccuaccccaagucauggugugcugagugacugaugaggggccauugagagccggugggc




u




cugccauggaacccuuccguugauuagcaaugacugugcuugacccacccaccuacccua




cuaaugaauuucuguagaguggauggacggguuugagggaagaaggguggagguggauu




aaacugguuuggggagggcuggggaccuagaagcagcccaguguguccccaccccuuuuc




c




gcacugucuugcuaauguucugaucacugugcgcccccucccucuucagaaggacccugg




gccucuugaguuggccccucugaguucccucccuuugcccauuucaaggacaccggccag




ucugcggaaggaagguacggggggggggggggggggugauggcauuguaccagggaguc




uccuggacuccccugccuucucugugguuucuuguuuuguaauuaaggucuguucacag




cuguaauuauuauuauuuucuacaauaaauggcaccugcauacag





34
U20735
See above (same Accession Number).





35
U83148
augcagcugagaaaaaugcagaccaucaaaaaggagcccgcaccccuagauccuaccagc




agcucagacaagaugcugcugcugaacucugccuuagcugagguggccgaggaccuagcc




ucaggugaagauuugcuccugaacgaagggagcauggggaaaaacaaauccucggcgugu




cggagaaaacgggaauucauuccggacgagaagaaagacgccauguauugggagaaacgg




cggaaaaacaacgaagcugccaaaagaucucgggagaagcgccgccucaaugaccugguu




uuggagaacaagcugauugcccugggagaagaaaaugccacuuuaaaagcugagcugcuc




ucccugaaauuaaaguuugguuuaauuagcuccacggcguaugcccaagaaauccagaaa




cucaguaauuccacagcugucuacuuucaggacuaccagacauccaaggcugccgugagc




ucuuuuguggacgagcaugagccugcgaugguagccggaaguugcaucucagucaucaag




cacucuccccagagcucgcucuccgaugugucagagguguccucgguggagcacacucag




gaaagccccgcacagggaggcugccggagcccugagaacaaguucccugugaucaagcag




gagcccguggaguuggagagcuuugccagggaggccagggaggagcggggcacguauuc




c




accuccaucuaccagagcuacaugggaagcucuuucuccacuuacucccacuccccaccc




cucuugcagguccauggguccacuagcaacuccccaagaaccucagaggccgaugagggu




guagugggcaagucuucugauggggaagacgaacaacaggucccuaagggccccauccau




ucuccaguggagcugcaacggguucacgccacgguggugaagguuccggaagugaacccu




ucugccuuaccgcacaagcuucggauuaaagccaaggccaugcaggucaaaguggaggcu




uuggacagcgaguuugaaggcaugcagaaacucucuucacccgccgaugcgaucgccaaa




agacauuuugaccuggagaaacauggaaccucggguauggcccauuccucccucccuccu




uucucagugcaggugacgaacauucaagauuggucccucaaaucggaacacuggcaucac




aaagaacugagcagcaaaacucagaguagcuucaaaacaggugugguggaagucaaagac




gguggcuauaagguuuccgaagcugagaauuuguauuugaagcagggaauagcaaacuua




ucugcagagguggucucgcucaagagauucauagccacacaaccgaucucggcuucggac




uccagguaa





36
L10244
gcucccgggaaacgaaugaggaaccaccuccuccugcuguucaaguacaggggccuggug




cgcaaagggaagaaaagcaaaagacgaaaauggcuaaauuuaagauccguccagccacug




ccucugacugcagugacauccugcgacugaucaaggaacuggcuaaauaugaauacaugg




aagaucaagucauuuuaacugagaaagaucuccaagaggauggcuuuggagaacaccccu




ucuaccacugccugguugcagaagugccuaaagagcacuggaccccugaaggacauagca




uuguuggguucgccauguacuauuuuaccuaugacccauggauuggcaaguugcuguau




c




uugaagacuucuucgugaugagugauuacagaggcuuugguauaggaucagaaauuuug




a




agaaucuaagccagguugccaugaagugucgcugcagcaguaugcacuucuugguagcag




aauggaaugaaccaucuaucaacuucuacaaaagaagaggugcuucggaucuguccagug




aagagggauggaggcucuucaagauugacaaagaguacuugcuaaaaauggcagcagagg




agugaggcgugccgguguagacaaugacaaccuccauugugcuuuagaauaauucucagc




uucccuugcuuucuaucuuguguguagugaaauaauagagcgagcacccauuccaaagcu




uuauuaccagugacguuguugcauguuugaaauucggucuguuuaaaguggcagucaug




uaugugguuuggaggcagaauucuugaacaucuuuugaugaagaacaaggugguaugau




cuuacuauauaagaaaaacaaaacuucauucuugugagucauuuaaauguguacaaugua




ca




cacugguacuuagaguuucuguuuugauucuuuuuuuuuaaauaaacucgcucuuugau




uu





37
U88328
cgcuggcuccgugcgccauggucacccacagcaaguuucccgccgccgggaugagccgcc




cccuggacaccagccugcgccucaagaccuucagcuccaaaagcgaguaccagcuggugg




ugaacgccgugcgcaagcugcaggagagcggauucuacuggagcgccgugaccggcggcg




aggcgaaccugcugcucagcgccgagcccgcgggcaccuuucuuauccgcgacagcucgg




accagcgccacuucuucacguugagcgucaagacccagucggggaccaagaaccuacgca




uccagugugaggggggcagcuuuucgcugcagagugacccccgaagcacgcagccaguuc




cccgcuucgacuguguacucaagcuggugcaccacuacaugccgccuccagggacccccu




ccuuuucuuugccacccacggaacccucguccgaaguuccggagcagccaccugcccagg




cacuccccgggaguacccccaagagagcuuacuacaucuauucugggggcgagaagauuc




cgcugguacugagccgaccucucuccuccaacguggccacccuccagcaucuuugucgga




agacugucaacggccaccuggacuccuaugagaaagugacccagcugccuggacccauuc




gggaguuccuggaucaguaugaugcuccacuuuaaggagcaaaagggucagaggggggcc




ugggucggucggucgccucuccuccgaggcacauggcacaagcacaaaaauccagcccca




acggucgguagcucccagugagccaggggcagauuggcuucuuccucaggcccuccacuc




ccgcagaguagagcuggcaggaccuggaauucgucugaggggagggggagcugccaccug




cuuuccccccucccccagcuccagcuucuuucaaguggagccagccggccuggccuggug




ggacaauaccuuugacaagcggacucuccccuccccuuccuccacacccccucugcuucc




caagggagguggggacaccuccaaguguugaacuuagaacugcaaggggaaucuucaaac




uuucccgcuggaacuuguuugcgcuuugauuugguuugaucaagagcaggcaccugggg




g




aaggauggaagagaaaagggugugugaaggguuuuuaugcuggccaaagaaauaaccacu




cccacugcccaaccuaggugaggagugguggcuccuggcucuggggagaguggcaaggg




g




ugaccugaagagagcuauacuggugccaggcuccucuccauggggcagcuaaugaaaccu




cgcagaucccuugcaccccagaacccuccccguugugaagaggcaguagcauuuagaagg




gagacagaugaggcuggugagcuggccgccuuuuccaacaccgaagggaggcagaucaac




agaugagccaucuuggagcccagguuuccccuggagcagauggaggguucugcuuuguc




u




cuccuauguggggcuaggagacucgccuuaaaugcccucugucccagggauggggauug




g




cacacaaggagccaaacacagccaauaggcagagaguugagggauucacccagguggcua




caggccaggggaaguggcugcaggggagagacccagucacuccaggagacuccugaguua




acacugggaagacauuggccaguccuagucaucucucggucaguagguccgagagcuucc




aggcccugcacagcccuccuuucucaccuggggggaggcaggaggugauggagaagccuu




cccaugccgcucacaggggccucacgggaaugcagcagccaugcaauuaccuggaacugg




uccuguguuggggagaaacaaguuuucugaagucagguauggggcuggguggggcagcu




guguguugggguggcuuuuuucucucuguuuugaauaauguuuacaauuugccucaauc




acuuuuauaaaaauccaccuccagcccgccccucuccccacucaggccuucgaggcugucu




gaagaugcuugaaaaacucaaccaaaucccaguucaacucagacuuugcacauauauuuau




auuuauacucagaaaagaaacauuucaguaauuuauaauaaaagagcacuauuuuuuaau




gaaaaaaaaaaaaaaaaaaaaaaaaaa





38
X82786
Sequence below.










aaggaaucuucaguacagaaacaagacccaaguguaaguuuaacuggcaggaggaaccaaccaaggacaguuaagga


gaaaacccaacccuuagaagaacucaccaguuuccaagaggaaacugccaaaagaauaucuuccaaaucuccacaacc


ggaagagaaggaaaccuuagcagguuuaaagaggcagcucagaauacaacuaaucaacgaugguguaaaagaagagc


ccacagcacagagaaagcaaccauccagggaaaccaggaacacacucaaagagccuguaggugacaguauaaauguu


gaagagguuaagaagucuacaaagcagaaaauugauccaguagcaagugugccugucagcaagaggccacggaggg


uacccaaggaaaaggcacaggcccuagaauuggcuggucucaaaggaccaauccaaacccuaggccacacugaugaa


ucagcaagugauaaaggacccacacagaugcccuguaauucucuacaaccagagcaaguugacagcuuccaaagcuc


accaaggcgacccaggacaagacgugggaaaguagaggcagaugaagagccuucagcaguaagaaagacaguaucaa


caucaaggcaaacuaugcgaucccgcaaggucccugaaauugguaacaaugguacccaaguuucaaaggccuccaua


aagcagacauuagauacaguagccaaaguaacuggcagcaggaggcagcuaaggacacauaaaggaugggguucaac


ccucuugaaguuguuaggugacuccaaagaaauaacccaaauaucagaucacucugagaaacuagcacaugacacca


guauccuuaagagcacucaacagcaaaagccagacucaguaaaaccucugagaacaugcagaagagugcugagggcc


ucuaaagagguccccaaggaaguguugguggacaccagagaccaugcaacauuacaaagcaaaagcaacccuuugcu


guccccgaagaggaagucugcaagagauggaagcauugugagaaccagggcuuugcgcucuuuagcaccaaagcag


gaagcaacagaugagaagccuguaccugagaaaaaaagggcugcuuccagcaagagguauguaucaccugagccugu


gaagaugaaacaccugaaaaucgugucaaacaaacuugaaucuguggaagagcagguuagcacuguuaugaaaacag


aagaaauggaagccaaaagagaaaauccugucacuccagaucagaacucuagguaccgaaagaaaaccaauguaaaac


agccaaggcccaaguuugaugcaucugcagagaaugucgggauaaagaaaaacgagaagacuaugaagacugccucc


caggagacagagcugcagaauccagaugauggagccaagaaaucuacaucucggggccaagucagugggaaaagaac


augcuugaggucuagaggaacgacugagaugccccagccuugugaagcagaagagaaaacaagcaaaccagcugcag


aaaucuugauaaagccucaggaagagaaaggagucucuggagagucugauguuagguguuugagguccagaaaaac


uagagucgcuuuggacagugaaccuaagccaaggguaacucguggaaccaagaaagaugcaaaaacucugaaggagg


augaagacauuguaugcaccaagaaguuaagaacaagaaguuaagaacaagaaguuaccagaaaagugaaacuaugu


agcaaagacauuuaagaaggaaaaguaaauuugacuuagugauaaguuccagugugguuuucaccuccaguguaaa


gaugaacuguaaauacuacugcuacugccugaguuuaaggaaggaagcuuugagcuuuccuggucauacucucuuc


agacgccaauggaggucaugaggaagaucaccagggaucucagcgcaauuacaguuuaggggugagcaggcagaaa


uguggcccucuguccuauccaauaaagcucugaaauucgcugccaaaa












39
AW122523
uuuuuuuuuuuuuuuuuaaaucaaaaguuaugaugacuuuauuuuaaaucuuaauacac




c




aaaaauauuuuucaauguugugagauaagcacuugaaaauaagaauuccaacacugcugu




gauuucgcugugaggcuugauagugaauuuucccucugaauauggguuuagggccuagg




a




agcagaaugccagucauuuuccaaguagcagugagcuaagcccagcccggucaugcucag




acccacacuuaacugaaauauucacacuaggaggcggcaccaccaggcaacaccuugauc




aaccaggagaacaaaagucugaagugccaccaagcauuggggaaaugauauuguuuagau




gcuagugagucagguucuuucaaauguguccuaacuggguugcaaacauaguugcauccu




uau





40
AI642048
gucuguaaaaaucuguuuaauaaauauacaucuuagaaguaccaaaauaauuaccaacaa




aauacaacauauacaacauuuacaagaaggcgacacagaccuuaguugggggcgacuuuu




aagcacaugccacugaacaccuggcucuuacaugggaggacacacugggcucacuuacua




ggucuauggugguucaaucaaaagcacaauaaauaaaacgugguccuuucauuagguucu




ggaaaaucaccucccccccccccaaaaaaaaucccacaaacaugaaccuuaagagacauu




uucuuugaauuucagugaucuguuuccccggauuucacaaagacaacagccgaaucaccc




caguaaaaugccugggucuaggcgcugugugguguggugcuaaguauacccuuucucau




u




uuuuuucuuuuucu





41
L07264
cggccgccagaccuucaagggcuggaguggacgcgcggaccgacucugaacagacagacg




aaccgcggccgcaagguucccagacaggaucucacccagaggcaggcagcggacagugcc




uuaguggaaccucgcuguccuccaccgccuggccccggugcaggcguccaguggccgccg




cauccaaagugaucgcugccuccccgucuccgccagcucgggaccaugaagcugcugccg




ucggugaugcugaagcucuuucuggccgcaguguuguccgcguuggugaccggugagag




u




cuggagcggcuucggagaggucuggcggcagcaaccagcaacccugacccucccacugga




uccacaaaccagcugcuacccacgggaggugaucgugcucaggggguccaggacuuggaa




gggacagaucugaaccuuuucaaaguugcuuucuccuccaagccacaaggccuggccacc




ccaagcaaagaaaggaaugggaaaaagaagaagaaaggaaagggguuagggaagaagaga




gacccaugccucaggaaauacaaggacuacugcauccacggggagugcagauaccugcag




gaguuccguacucccucuugcaaaugccucccugguuaccacggacacaggugucauggg




cugacucuaccaguggagaauccccuauacacauaugaccacacuacagucuuggcugug




guggcuguaguacugucguccgucugucuucuugucaucgugggacuucucauguuuag




guaccacaggagaggagguuaugacuuggaaagugaagagaaagugaaguugggcgugg




cuagcucccacugaggaggaccugagcuauaggaaccuucagaggcuacuucugagacag




ug




guucguuacacguucuacauagaggagaaauauuucaccagcagccaugaaaacgucuuc




auucauuuccaguugcuacccugacugggccuccuguaau





42
M15668
ucgaccucacggucuugccaaaaugucgcuuuccaacaagcugacuuuggacaagcugga




cgugaaggggaagcgggucgugaugaggguggacuucaacguuccuaugaagaacaacca




gauaacaaacaaccaaaggaucaaggcugcuguuccaagcaucaaauucugcuuggacaa




uggagccaacuccguuguccuuaugagccaccugggccggccugaugguguucccaugcc




ugacaaguacuccuuagagccaguugcugcugaacucaaaucucugcugggcaaggaugu




ucuguucuugaaggauugugugggcccagaagucgagaaugccugugccaacccagcggc




ugggacugucauccugcuggaaaaccuccgcuuucauguagaggaagaagggaagggaaa




agaugcuucugggaacaagguuaaagcugagccggccaaaauugaugcuuuccgagccuc




acuguccaaacuaggagaugucuaugucaaugaugcuuuugggacugcacaccgagccca




uagcuccauggugggugugaaucugccacagaaggcugguggauuuuugaugaagaagg




a




gcugaacuacuuugccaaggcuuuggagaguccugagcgacccuuccuggcuaucuuggg




aggcgcuaaaguugcagacaagauccagcugaucaauaauaugcuagacaaagucaauga




gaugaucauuggugguggaauggccuuuaccuuccuuaagguccucaacaacauggagau




uggcacaucucuguaugaugaagaaggagccaagauugucaaagaucucauguccaaagc




ugagaaaaauggugugaagauuaccuugccuguugacuuugucacugcugacaaauuuga




ugagaaugccaagacuggccaagcuacuguggccucugguauaccugcuggcuggauggg




cuuggacugugguacugagagcagcaagaaauaugccgaggcugugggucgagcuaagca




gauuguuuggaaugguccuguugggguauuugaaugggaagccuuugccaggggaacca




a




gucacucauggaugagguggugaaagccacuucuagggguugcaucacuaucauaggug




g




uggagacacugccacuugcugugccaaauggaacacagaggauaaagucagccaugugag




cacugggggcggugccagucuagagcuccuggaagguaaaguccuuccugggguggaug




c




ucucagcaauguuuaguauuuucuuuccugccuuugguuccugugcuccuaagcuaacc




u




gcuguuuuccacaucuccauuugguguuagcgcaagauucagcuaguggcugagaugug




g




cacagaccuuaacagugcaagcaucucagcucgucuuacugcaucagaugcugguucuuc




aagaucccauuuaaauuccuuagugacuaaaaccauugugcauuguagagggcgucuauu




uauauucugccugagaaaggaagugagcuguaaaggcugagcucucucucugacguaugu




agccucugguuagcuucgucacucacuguucuugacucagcauggcaaucugaugaaauu




cccagcuguaagucugcagaaauuuccgaauuc





43
AI047508
uuuuuuuuuuuuuuuucauguuuaauaguuuauuucuuauuuuguugcuuauaucuuc




aauaaaucauuuugcagguuuuguuacagauuuuugauaagccaacucaaguacugauuu




uucauccucucugaaaguuuuaaaccaggaaaggaaaacguuccauggaauccaucuucca




cauggugaugagucacaugaacuccaacauucugaagccgcuugacauacaugaguccau




c




aucucuuaggacaucauacuggcaagugaugauauaggucuuagguaaaugaugcaauau




auugucauuggccaacagagggcaugccuucacaucuaugaacccuggauacuuuugagc




cagcucagaacuaccaggagugggauuuuuguaaacgggacuuuucuuguaucucucagg




gagcaaggaacuccaauucacaaacuguaacaaguggcuagauuccauggguacauguug




guuga





44
AJ001418
Sequence below.










gagcacccgggacccugggaccacaacgcacuugcucccucucgaccgcgcuccugacccgcagcccucgccaacccuacgg


auccuaaccaccgccagccuaggugggcgucaggaugaaggcagcccgcuucgugaugcgcagcgccagcucgcugagcag


cgccagccugguccccagggaggucgagcuguucucccgcuacagcccguccccgcuguccaugaagcagcugcuggacuu


ugguucagaaaaugccugugaaagaacguccuuugcuuuucugcggcaagagcugcccguccgccuggccaauauccugaa


ggagauugacauccugccugaccgcuuagugaacacuccuucggugcagcuggugaagagcugguauauccagagccugau


ggauuugguggaguuccaugagaagagcccagaagaccagaaagcccugucagaguuuguagacacgcuggucaaaguucg


aaacagacaucauaauguggucccuacaauggcucaaggcauccuggaguauaaagacaccugcacaguggaccccguuacc


aaucaaaaucuucaguauuuuuuagaccgguuuuacaugaaccgcauuucuacucggaugcucaugaaucagcacauccuc


auauucagugacucaaagacgggaaacccaagccacauuggaaguaucgacccaaacugugaugugguagcaguaguccaa


gaugccuuugagugugcaaagaugcucugcgaccaguauuaucuaacaucgccagaauuaaaccucacacaagucaaugga


aaauuuccaggccaaccaauccacauuguguacguuccuucacaccuucaccacaugcucuucgaacucuucaagaaugcca


ugagggccacggucgagcaucaagaaaaccguccuuccuugaccccaguagaggccacugucgucuugggaaaagaagacc


uuacaaucaagauuucugaccgaggaggcgguguuccucugaggauuacugaccgccucuuuaguuacacguacuccacug


cuccaacaccugugauggacaauucccggaaugccccuuuggcugguuuugguuauggcuugccaauuucucgucucuac


gccaaguauuuucaaggagaucugaaucucuacucuaugucagguuaugggacagacgcuaucaucuacuuaaaggcuuua


ucuucugagucuguagaaaagcucccagucuuuaacaagucagccuucaaacauuaucagaugagcuccgaagcugaugac


ugguguaucccaagcagggaaccgaagaaccuggcgaaggagaagcuggcagugugaagcggaugacgccugacauuuuac


gggaucaaagugggucuguggcauugcugcuucgugaauguguguggacucuaguuuccgcaaaacaacgcaacacaaaac


caagcaagcaaaacacaaacacgaguacaaaccuugaccugaugagggacagagcuugguuggaugacccgggagaagucag


ggcagggcuccaggggauaacagguguccugcuucuccuuuggcaaugcaaaaugacuccugacuguuccaaauacugaaa


agaagucugccucugaguuacagcucuuucucaacaaguacagaguuugaggcuugcaguugcaacagcuggauguuugg


ugguucuugcugccagccaaauaaauugguguuuagugaacauuuucaguguuuccccgccaugcaaagcuuggcgccuu


gggagaaauguguguaaauguacauuguauagguauuagugugcucuagaaaggacaggauggaaggaaucaaagcacuu


uaucgagcuuguggcugagcauugcagccuaugugcaaacccagaggaaaaguaucucugucaagacagcuccaguaucau


gcagcuuuuuauguuugcacucaaaaagccagugccuucuggcuggugccgaggcuugggugaaauguuaaauaugcacu


gaccucagaaagucgaguucaaaagggagauaaaauugccaaagugauccaaggauugugcauguugggaaacccauauga


gagaaaggauucucauacuuagaacuuuccuaugaagaaauggugguaaacuuucucuaccuagaaguaguggaaauuuca


aggucaucuuaaaaaagaugugcguuguauauuuuaacuacauucucuacacucuaacauuaacauaucuauucaaauuug


ucuaguugccaauugucuucagagugugaaaauuuaaauccuucuugaaguaucuuucgugagaguaguauggaaguaaa


acguucucauaucaggaggaugucauuugugaagcauggggacaucaugaacuagugaugugcgugaggcuugggaggcu


gaaggguaaggaucagcgggaggccauccauguaggagagagaauuaaaacgaggagcgagggaagcaauggagagaggga


agcaagaaaggaaccagaaggcuggcaucauccuauuucccacaggcuaacccaagggaugcucugugccuuuccugggga


gggaagggggugaacugguagauuugaaagcaguauggcuucuucugugggucucccucuuacuagacaaggugaaauga


uaauucgugucaaauuaaugugaaauuuuuuuccugcauuguaauauuaugaggccugagucgcaguugaguuugaaauu


uguauuuaauuucacagugaccuagagcuaaggugcucccgguuguggcaauaggagccacaaguauuuucuuucuuucu


uucguucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuuccuuccuuccuuccuuccuuccuuccuuc


cuuccuuccuuccuucuuccuuuccuuuucuuuucucuucucuucuuuucuuuuuucuguuucuuuuucuuuuuuugca


uuguagauguuguccuuaaaagaucagggcagugacuuucacagcaggacuuugacucccacauugguugaucacacaaaa


cugucagcauuuggguaaucugauguauaguuguuuuguugcugauguuuccauugaaauuucagcucugaguuugugc


acaugaauacuuacuuguguuuaccaaaggucuaaggcauuugguuacuuaacccaaauauccugaacugugcguaaagua


auagagaaaagcuuuagggucucaauagugucaccuguguaaaucaaaucaaaauagccuucccuauuauuuaugaaccca


ugggagacuuuaaacucuuguagauagaugcuaaaugcccaggcccacuuaacuuauuaaugugugaauuacauuuaugu


uuuuaguuuauaugcaaagaauugugauaauuuuauaauaaauauuuuuauuauaauagu












45
AI838080
uuuucuuuuuuuuuuuucuucucuuuuuucugccaccaacagcacugugcaguuuauua




accauucauguacaguagccaucuggggagauugggacagaauugggaucgcaaagugga




uagauauucagcaucuaauggguuggcagaagccgccauauacucuucacaaauaucuuc




c




acagucaauacagaacuagccauuaucccagcacaccgauuugugc





46
AF072127
agccaggagccucgccccgcagcugcacagagagcaaggguauaggcacuaacuuguuug




cagagaccccaucaccuucgggagcucaggugcgcaccuugcaaacuccacuuucugcau




cugccacugagcccgcgggagccucggaaagagccauggccaacgcggggcugcagcugc




uggguuucauccuggcuucucugggauggaucggcuccaucgucagcacugcccugcccc




aguggaagauuuacuccuaugcuggggacaacaucgugaccgcucaggccaucuacgagg




gacuguggauguccugcguuucgcaaagcaccgggcagauacagugcaaagucuucgacu




ccuugcugaaucugaacaguacuuugcaggcaacccgagccuugaugguaauuggcaucc




ugcuggggcugaucgcaaucuuuguguccaccauuggcaugaagugcaugaggugccug




g




aagaugaugaggugcagaagauguggauggcugucauugggggcauaauauuuuuaauu




u




caggucuggcgacauuaguggccacagcaugguauggaaacagaauuguucaagaauucu




augaccccuugacccccaucaaugccagguaugaauuuggccaggcccucuuuacuggcu




gggccgcugccucccucugccuucugggagguguccuacuuuccugcuccuguccccgga




aaacaaccucuuacccaacaccacggccuuaucccaagccaacaccuucuagugggaaag




acuaugugugacagaggcaaaggaagagaucuuccuggagcaaauacaaaauggacauug




aaccuaggauugacauuaacgccuuagacuguugaugaugguuaucggaacugugguaga




acagaaggaagcauauuuuuauacauccccauggcuaugcaggccuuggcug





47
X80417
Sequence below.










cggcacgagcggccacugaccgagaagugcccccgccuggagucagccugggggcaggccaggguccaccagaccc


cgggaugaccgcagccagucgggccaaccccuacagcaucguaucaucagaggaggacgggcugcaccugguuacca


ugucaggcgccaacgguuuuggcaauggcaaggugcauacacggcgccggugccgcaaccgcuucgucaagaagaa


cggucagugcaacauugaauucgccaacauggacgagaagucacaacgcuaccuggcugacauguuuaccacgugu


guggacauccgcuggcgcuacaugcugcucaucuucucucuggccuuucuugccuccugguuguuguuuggcauc


aucuucugggucauugcugucgcccacggggaccuggagccagccgagggccguggccguacacccugugugcugc


agguccacggcuucauggcagccuuucucuucuccauugagacacagaccaccauuggcuacgggcuacgcugugu


gacugaagagugcccgguggcugucuucauggugguggcgcaguccauugugggcugcaucauugacuccuucau


gaauggugccaucauggccaagauggcacggcccaagaagcgcgcacagacucugcuuuucagccauaaugccgug


guggcucugcgugacggcaagcucugccucauguggcgcgugggcaaccugcguaagagucacaucguggaggccc


augugcgggcccagcucaucaagcccagggucacagaggagggugaguacaucccacuggaccagauugacaucga


ugucggcuuugacaagggccuagaccguaucuuccugguaucacccaucaccaucuugcacgagauugaugaggcc


agcccacuguuuggcauuagccgucaggaccuugagacagacgacuuugagauuguggucauccuggagggcaugg


uagaggccacagccaugaccacacaggcucgcaguuccuaccuggcuaacgagauccuguggggccaccgcuuugag


ccagugcucuucgaagagaagaaccaguacaagauugacuauucacacuuccacaagaccuacgaggugccaucuac


accccgcugcagcgccaaggaccugguggagaacaaguuccuccugcccagcgccaacucuuucugcuaugagaacg


agcuggccuuccugaucagagaugaggaggacgaggugucuaccgaccgggauguccgcaccccucagcccgagca


ugacuuugacagacugcaggccagcagcgcugcccuugugcggcccuacagacgggagucggagauuugaaugccc


uuggcuuagaugcagcaccacccugaccacaauaggucccaugucccuugggggccugcguuugagcagagcaggc


cgaaagccucgggucacagacucaguagcaucuuagucuuuuucauguuuuuucgcaguagcuugggaaaguugg


cgggagcguggauggcccaaaugacuggcucacggccucggaggcugauguauacccaugggcaaggaggugacuu


cuugggguaggguugcucaggaguuagggacucugcuggaggccuuaggugcaggucccaaccccggugggagga


ggcuguguauguacacuucauugguuuuuaacuugggcaagacuguuuacaaaccaaaacaaacaaacaaacaauc


caaaaaaaaaaaaaaaaaaaaaaaaaaaa












48
AI847051
uuuuuuuuuuuuuuguuccuuuuuuggaauucccaaagcugguuuuaauuucaaaaaau




uaugaggucucuucccacacuggggauaaugggaugggauagcccaaacuauuaucccag




u




ucaaccccagccugguccaaacaccauuacugucacugggcccugucauuucacc





49
U09504
uccucguccucgucuguuccaucuucuccaaauagcucuaacugugaugccaacggcaau




cccaagaacgcugauaucucuagcaucgaugguguucugaagagugaccgcacagauugu




ccugugaaaacaggcaaaaccagugcuccuggcaugacuaagagucacaguggaaugaca




aaauuuaguggcaugguucuacuguguaaagucuguggggauguggcaucaggauucca




c




uauggaguucaugcuugugaaggcuguaaggguuucuuucggaggagcauucagcaaaa




c




auccaguauaagaagugccugaagaaugagaacuguuccaucaugaggaugaacaggaac




cggugccagcagugccgcuuuaagaagugucugucuguggggaugucacgagaugcugu




u




cgauuuggccgaauuccuaagcgugaaaaacagagaaugcuaauugaaaugcaaagugca




augaagaccaugaugaacacccaguucaguggccaccugcagaaugacaccuuagcagaa




cagcaugaucagucagcacuaccagcucaggaacagcugcggcccaagucccagcuggag




caagaaaacaucaaaaacacuccuucugauuuugcaaaggaggaagugauugguauggug




accagagcccacaaggauaccuuucuguauaaucaggaacaucgagaaaacucaucugag




agcaugccaccucagagaggagaacggauucccaggaacauggagcaauauaauuuaaau




caagaccaucguggcagugggauucacaaccacuuccccuguagugagaggcagcaacau




cucaguggacaguacaaagggaggaacauaaugcauuacccaaacggccaugccguuugu




auugcaaauggacacuguaugaacuucuccagugcuuauacucaaagagucugugauaga




auuccaguagguggauguucucagacugagaacagaaauaguuaccugugcaacacugga




gggaggaugcaucugguguguccuaugagcaagucuccauauguggacccucagaagucu




ggacaugaaaucugggaagaauuuucaaugaguuuuaccccagcaguaaaagagguggug




gaauuugcaaagaggauuccuggcuuccgagaucugucucagcaugaucaggucaaucug




uuaaaagcugggacuuuugagguuuuaaugguacgauuugcuucauuauuugaugcaaa




g




gaacggaccgucaccuuucuaagugguaagaaguacaguguggaugaccugcacucaaug




ggagcaggggaucugcucagcucuauguuugaguucagugagaagcugaaugcccuccag




cucagugaugaggaaaugagcuuguucacagcaguuguucugguaucugcagaucgauc




u




ggaauugaaaaugucaacucaguggaggcuuugcaggaaacacucauccgugcacuaagg




accuuaauaaugaaaaaccauccaaaugaggccuccauuuuuacaaaauuacuucuaaag




uugccagaucuucgaucuuuaaacaacaugcacucugaggaacucuuggccuuuaaaguu




cauccuuaa





50
U22033
auggcguuacuggaucugugcggugccgcucgggggcagcggcccgagugggcugcccu




g




gaugcgggaagcgggggucgcucggacccgggacacuacaguuucuccgcgcaagcuccg




gagcucgcacuuccccggggaaugcagcccaccgcauuccugagguccuuugguggugac




caggaaaggaauguucaaauugagauggcccacggcacaaccacacucgccuucaaguuc




cagcauggcgucaucguggcuguggacuccagggccacugcagggaguuacauuagcucc




uuaaggaugaacaaagugaucgagauuaacccuuaccugcuuggcaccaugucugguugu




gcagccgacugccaguacugggagaggcuguuggccaaggagugcagguuguauuaucu




u




cggaauggggaacgcaucuccgugucugcagcauccaagcugcuuuccaacaugaugcug




caguaccgggggaugggccucuccaugggcagcaugaucuguggcugggacaagaaggga




ccaggacuuuacuacguagaugacaaugggacucggcucucgggacagauguuuuccacu




ggcagcgggaacaccuaugccuacggggugauggacagugguuaccggcaggaccucagu




ccugaagaggccuacgaccuuggccgcagagcuauugcuuaugcuacccacagagacaac




uauucuggaggagucgucaacauguaccacaugaaggaagacgguugggugaaaguggag




aguuccgaugucagugaccugcuguacaaguaccgagaggccgcucuguga





51
AF033034
Sequence below.










auuccaggaguuccagcugcuggagaggacuguguagaagguaaccuaccccaucucucuuacuucgucucuagaugggag


cagacaaguacauauagccugcuuggagcgaggacuuugaaaggcugagacuugcguccacucugagggcaacuaguccag


acucugacaggucagcauuuccugacugggugcacugaaugccaagcaccagaggucugucaccuuccgacauuggaccaa


gagagucccagagacccucaaagacacaggaacagagguguccuuugggugagagaccugugcccugccaagccucucagc


cccuagaaaggcggcagggcugaguagcugagugugugcaacuugggagcagccugauuucagugcuugucaccugugag


ggcaaaggcagcaugcuuaaugccaucaguccuacucuucucacccguggaacagacgcauaacugaccuuuuuucgugac


cacuauuagggugcauuuaaaaaucaaucucucucuuuucugcuccucuuucuccaccuucccucaugugugugucugug


uguguguguuucugugugugugugcgugcaccauacagguauaugugccaugacaugugugcaggucaguagacagccu


ugguugucagucccugccuucuacuuuguucaaggcagggucuauucuuuauuauugacugcuauccagguacaccaaga


caguuggccugugagguuccagggagucuccugucucuggcccccaucuuauagcaggaguugugagauuucagaaaugu


gcacccacaucuagcuuuauuuggcaucuuggcacccaaacuuggguucucaugcuuuccaagcaaggacuucacccacug


aaccaucucaccagcuccacuauggcgguuuucugaaacugaagggaguggggagaaggcgcugagugugaacgggucug


gaaggcggguauaaccuuuaaggcuggcugguucugagagaggaaagccggcuugugucccauucaggugccaggugcag


caucaaauguggcuccacccaacggucaguaacuccgcagacagcaccgugguuaacugccucacagagggggcccagggac


cuaguuccuuaaagcccacuuaguuuugagagacgacauggaggggcaagcccagcccuguccagcugcauucacacgagg


cccuucuccuccgaggacccuaccuuuguguuuaguggcugaggcuguguggcucugcuugaagcucuggcuaucaggaa


ggaccuggcccaccggcuggcaggacaaacuggcccagugaaggcacuguccggucuccugguggaucacaaggaaagggg


cguggcauguccagauuugaacccuggaugccucuucccaggguaggaagucuaagggucaacaugaauaggugagggug


gugguggaaagaaucugcaugcaaaaucaggcacucaugucugacaucgucaaacacuauauuuauguagauuuauauggg


ggugaggcuuggggagcacuuguauuuuugugugcaauugcaagagcuuccuccacauugcaguguuaaauaucauaugg


ugcuggaccaaccaucucuggaacgagggugaggguuugguacccgugacuaugguucucuguguaguagaaacggcuuc


uugggaagagagaggaagugcuuugaaaugcauccucucuuguuucauucugcaucauggccagguuucucugcacaaag


augcaauagacauucaggaaaauaagcgcauugcaagaugucaaaagucaugaaaaaugaaaagcaaggucacugcagcugg


gguguaguguggcuguagaagcacguuuaugauguacagguuccgggagagggaggaagagagagggagggaaggaggaa


uggaggaagagagggagagggagcaagagaggggggagggagggaggggagaagggagagagagagagaagaaagagagg


gagggaagaaggaauggaggaagagagagaaagaggggaagaaagagagggagggaaggagggguggaggaagagagagg


ugugagggauggagggacagagagggagggaaggagaaauggaggaagagagaaacagagagauggaggaagagagaaaa


gucaccaauuauuuuucuccccagucgcccccugcccucacaccaaggguacccccacuuuucuuucacucaugcacacaca


cuacacccaauguuuagguaacacauguagggcaggcagagccuuugugaaugugcuugguaguuuucugccuuacuucu


aaauaaccaaucacacggaugccacaggguuccuuuagacuguccagggcuccggggcucuuagacuguucccaauguggg


ugucacaugcaaacaguaagcaccuucuuguuuguggugcccaggaugcugcagguacuagaaauuccugcacagaccuuu


gcuacuucuacacagacuuacccuuuaaaacauuuaauuauauguuuuuuucagcauaaagaucuauuuugauuauuuuua


guugcguguaugggugugugccugugugugauuguguaauugucuguaugggaguguaagugccuacagaggcaucgga


uccccuggagcugccguuacaaguaagggacugggacucagaccugagugguuuggaugagcagugaaugagcgugguga


gccaucccaccaugcccuauaaacacuuucaagaggacuuugcuggguauggucaaguugucccccugcgacagccacccca


acuugccauccucauuuacuguacuggaagcagcaaccaccucugcaauuuugcacaagaaccugagagucugaaagacuu


uuguuggcacuggccuguguuccacugggguggacacauuaaucuaaaagcuaagaagcucacuucagcuuugccaggcaa


ccagcacguuugagcacaacgguguagccaggaagggugugugggaauuuugaugcuaguuuuucuuuaauuagguugag


agugaaaucauggucuguaugcauccaacaacuuaauccaaaaaguugguugcacggcuccuggaagguuuaccggcaagg


aaccugucccauuuuguaaguaggugggacuggagaguugccaagaagccccccucccugcccccuuccuccuggcagauu


cugcuuaaaaugagugugguucacugcagaauagugucaccugucuucagaugucuaaagacauaagaaaggccuagccag


cuaagucagaaaaggggacuuuccggugggaaugcauuuuccagucucuaggagaagucuuuauccaaauaaaauuagcau


agugguggagucacugccagggcgcuggugcggaagcacagcccagagccgaggacguggccauccuccuuccucugaugc


aaaguguucucuauccccaguuaccaugagcaauaucaguagcaucgugaaccgggcccgugaugccuuuaacucaggcaa


gacucgaccgcugcaguuccggguugagcagcuggaggcguugcagcgcaugauc












52
AA960603
uuuuuuuuuccaaaaaauuuuauugggggaaacuacaaaacauuuacaguacaauguuua




cagucacaauuuguagugaacugauuccccaaaauauauuacaacucaaguugacuuaau




cuuguuacauucaaaaaccuacuucugucaaaguaguccagagugcacacgcggugcucc




aacuguaccuacauacaaacuaaacaacugcucauuuaucugccauccaggaaagccgga




gacauuccugccucuuuacauugaaaaauaauaguacaaguuuuuggacugucauugaac




aaggcauauucauguaccaccaacauuuc





53
U47737
Sequence below.










ggugauccuccaggaccuaagguuucgguauuaucuucggggccucuucacccggaggugagucugcugagcccgaccuc


agguguucacucgucacgcgagggccuggccacggcggggaagcacugggagagagcgggaggccuugaccgcagcgugu


aggaucuggggucccggcgcucugcucccgggugcagagugguuggagcaugcgaggcccucugcagcgugcucuguucc


uaccaucaccccacccccaccccaguccuuccugcacguuucuggagaggcaaaggccccugcugagccuucacuggguacc


ccuaucucgacuccacuugucugcuugggaucuccaaagggggauacacccucguaaacuagagcaggaggcuggggggug


gggguagggguagggucugaccaguuagauugaggcuggacccuccccagagugaggagcgggaagcucuuugucuuauc


caggauuuugcauaucaaugcugagguucuggugauuaaguagggucccuggcuagcggggguaaccugaacaaccuucc


uccgcuggccgcuagccaauagacaccuggcuuccgcggaugagcccuuugaguuuguggagguguuccucaggucccca


gggcccugccccguugccugcagauguguggacagacaaaacauuggacucguuuuccaaccacuucaccccuuccuucgc


uaguccuccgguggacgaugggaugccucauugacuuguuuguggcugugcaugccagagcuuccuagcagacagcucag


ggcuccaucguuccuaaaucccacuguguaacgaaaaaaaaaaaaacaaaaacaacaacaacaacaacaacaaaaacaaaacca


gaaaugaggacaggcccagcugggcuuggcacugaacuuggccaccuggagcuuuggcuacccacuacaagaugucagcaa


gucucaggauagaagaggccuaaggccaguccuggaagauaccaaaacuucaccuccucuauaccccguuccucuaggagaa


cuguaagccaccuuugucucugggacgccccucucccacucaacagauggcaccagucaucuuccuccucaagaggccagug


guauucaaaauaggauauugaaaccaagcaagcugguccucuccucuacccuaugccaaagacuucugcccaaagggcccag


aaaagucccauagccaucuggcuggcuagugugcugacugcuacaggugucaguguccccagcgagcagguaguggagug


gaggugucuucuuguggaaauggguccugagccucuaccuuguacagaaaggaauuagugaagcccagaggccuccagccc


gugucucugccacaagagagaggggguggggguggggcuguauuugguucccagggcucagggaagguuuucgguucau


gcaugcucauuuaucugaccacugucuuaaccccaggacaaccacuuaacuguccacuuccauaucagaguucuugguucc


ccuuuacuucgucuauggagccccugaguuugggaagggguauuaacugaaagguaccauuagaugaacuuggagaaaga


uuuguaggugccacgggagauuucagguaaaagcucuuuuaauaauuggcuacaauagcagcaggaggaggccaggaauu


cugagguagagauuugauuagcagcacguggagcaaaggagacuucugacuccuacagguuucagaaaguggggagaggc


ucucagaugaauggcuuggacugugagguaaguguuaguguagcacgagacuagcuuaaggcuguacaaauuguccgucu


gauuggugcauugggccagguagacacuagauaagcaauugggccuuaacucgaguugucuuaauggcuacccccagggca


gcagggagucaauacugcucuccugucuggggccugaaugcugaaaccaucuacaaaggggacauaaggcauauuggggag


guguagagugggccaggcccagggucugcugguaucuaugccaggauccugaguggugguggcguagccugucuuuuaac


caacugccucucucacaguaggcuucuuuggcuugcgaaccuucagcagaugucugccacuuccaacaugagagucuuccu


gccugugcuguuggcagcccuucugggcauggagcaagguauggagcucugagauaacccugcagccugguccuccuccu


gaucucucauucuuucuccugaguagaugcccagggcuccuccugagccagcccuccuaggaacgucuggccuucccaccu


ccuacucucuagccaacugaccuaguuccccugaugcugugcuggcccagcuacaccuuugucaccucguguugacuuuag


ccacuccaguaccaaagucugaagucaguugucauuggcuggcuuuuuucccugacccagggcugagcaugcuguugcuu


cuugucaguggguuggggaucaagggccccacuggaaagucaccuuacccuggaaggcuuccccaggcaauaggcaggugu


caccuacagcauugucccuuuugcaguucauucccugaugugcuucucauguaccgaucagaagaacaauauaaacugccu


guggccaguuucaugccaggagaaagaccauuacuguaucacguuaucugccgcugcgggcuuuggugaguagcugccug


uuucccuagccagggccagggaccugcggggcuuuccccauuuccugcuacccugucugucuguccccucauccucacuuu


ccaugcagggaaugucaaccuuggcuacacccugaacaagggcugcuccccgaucugccccagugaaaaugucaaucucaau


cucgguguggcguccgugaacagcuacugcugccaaagcuccuucugcaacuucagcgcagcuggccucggacuucgugcc


aguaucccacuacugggccuuggacuccugcuuagcuuguuggcucugcugcagcugagccccugaccaucccccaugugu


ucuccauauccccccagcucaggaaaagcccagcuccuuuuaggucccaggggacccuaggaaccuucagcuccuccugggu


gugucuaguucccccuccacacucucucaacgucagggcuaaguaccaaacucacccauaccugcucuguugaagugguac


uggcuacccuugcuuccagagccaauccuauaaccucccuuggggaaccagcgaaggggugaagaucuccuuggagucuca


agaguaccagagucagcgccgaaucuuguggacacacugacaaggaugucuaauccaaauagauguauaucugugugcuca


guguaucccugugugaaugaagccacuuggauucuggggugggcaaagaagaccugaaaagauucuacagcagaaggccug


ugucgccaccaaaaccccucccccugguaucauuguacccaccuuguacucuguucaggaggcugcccauggaggacugcc


accccuccagaugaaggcucccacuacccgaugcaguugagucccauccugcccucucugcccacacuggcuuccugcugcu


auucuagugccucaaauaaaccguucacacccuu












54
L00039
cuuccucccucuacagaagaagagcaagaagaugaggaagaaauugauguggugucugug




gagaagaggcaaaccccugccaagaggucggagucgggcucaucuccauuccgaggccac




agcaagccuccgcacagcccacugguccucaagaggugccacgucuccacucaccagcac




aacuacgccgcaccccccuccacaaggaaggacuauccagcugccaagagggccaaguug




gacaguggcaggguccugaagcagaucagcaacaaccgcaagugcuccagccccaggucc




ucagacacggaggaaaacgacaagaggcggacacacaacgucuuggaacgucagaggagg




aacgagcugaagcgcagcuuuuuugcccugcgugaccagaucccugaauuggaaaacaac




gaaaaggcccccaagguagugauccucaaaaaagccaccgccuacauccuguccauucaa




gcagacgagcacaagcucaccucugaaaaggacuuauugaggaaacgacgagaacaguug




aaacacaaacucgaacagcuucgaaacucuggugcauaaacugaccuaacucgaggagga




gcuggaaucucucgugagagcuaaggagaacgguuccuucugacagaacugaugcgcugg




aauuaaaaugcaugccaaagccuaaccucacaaccuuggcuggggcuuugggacuguaag




cuucagccauaauuuuaacugcucaacuaaauaguauaaaagaacuuuuuuuuaugcuuc




ccacucuuuuuucuuuuuccuuuuaacagauuuguauuuaauuguuuuuuuaaaaaauc




g




uuaaaaucuauccaauuuuccauguaaauagggccuugaaauguaaacaacuuuaauaaa




acguuuauaacaguuacaaaagauuuuaagacauguaccauaauuuuuuuu





55
D21099
gugggacgggccccccucgaggucgacccacgcguccgggaguacccccgaccuuggcug




cgugcugacucgcuuccuucugccugcccaggcuugcacuccccggggaucugccucugc




aucucuugccuucgcuguuguuucccucucuguccagcuccccucccgcucucgcccugg




agaauggcucagaaggagaacgccuacccguggcccuacggcucaaagacgucucagucu




ggccugaacacguugucccagagaguccuacggaaggagccugccacgacaucugcgcuu




gcucucgugaacugguccaacagccaguccacagcugccccuggccagaaguuggcugag




aacaagagucagggcuccacugccucgcaaggaucccagaacaagcagccuuucacuauu




gacaacuuugagauugggcguccuuugggcaaaggcaaauuuggaaacguguacuuggc




u




cgggagaagaagagccguuucaucguggcacucaagauccucuucaagucucagauugag




aaggaggggguagagcaccagcuucgccgagagaucgaaauccaggcgcaccugaaacau




cccaacauccuucaacucuacaacuacuucuacgaccagcagaggaucuacuuaauccug




gaauacgccccucgcggggaacucuacaaggaacugcagaagagucggaccuucgaugag




cagcggacugccacgaucauggaggaacugucagaugcccugaccuacugccacaagaag




aagguaauucacagagacauaaagccggagaaccugcuguuaggucugcagggagaacug




aagauugcagacuuuggcuggucggugcaugccccaucccugaggaggaagaccaugugc




ggcacgcuggacuaucugcccccagagaugauugaggggcgcaugcauaaugaaauggua




gaucuauggugcaucggggugcucugcuaugaacugaugguggggaacccccccuucga




g




agcccuagccacagugagacguaucgucggauugucaagguggaccugaaguuccccucu




ucugugccuucgggcgcccaggaccucaucuccaagcugcucaaacauaaccccuggcaa




cggcugccccuggcggagguugcagcucacccuuggguccgggccaacucaaggaggguu




cugccucccucugcccuuuagccugcuccuugguuuuuugucccugucauuuuucagug




u




ucuuuguaugucuguguauguguucugagaaggggugggaacuggaaacuauuccuagc




uccaguucuaggggaucugaucucucuucugaccucuacaggcaaaauuaggcaccccug




u




ggugcacauauaugcacgccaaacacaugaaguuacaaacaaacaacaaacacacagaua




gugcuggagagauggcucggcaguuaaaagcacuggcugcucuucccaggaaccuagaac




ucaauucuagcacuacauggugcucacggccacugucuguaacacccaguccuggggaau




cuggggccuucgagccucugcaggcacuaggcauggaugugguauacauguaugcaggca




aaacacccaugcacugacuuuuaagaaacccucuagucugauuccuuucaauuugucaaa




uguugaauguuauuuuuaaaauauuauaagccauuuaauacaauuuuucuuugaaacaug




guauagccuagucugucuuaaauucagaaaaauuaugaagaacaacauuuuauaauaaag




ucuuaaauguuucauguuuuug





56
AF026481
Sequence below.










uugccuaggaagggcgcgucgucucucugcucguccggcugugacggggaagggucccgcugcguuuuggucacugugag


uaccaaguuugggggauccccgagggacucucgagagcucauuuuagggaugcaggggcuacuccccggugguagagagc


uuucuaguuggcaggagguuucguauguggaggaggccagcuuaggcagaaagcacauguucucagagaugaggacaaga


cuaagaccgucuaaucccugaucuuuaccuuccggcccgcugaccugggccuggaugcuaaagcccucugcuuucgucuaa


acagcgcuaaauaguaaacaguauugccuaagauaaaugcggauuauuacccgauucagugucgggaaaaggcagcuagga


gagagcggcuggcacgugguaagcacacgguaaguuucgguuaaauuaaaacaaccauccguugagcaucucuuagcaagc


uccuuccacccuucaaacaaucagugauagugcgucuguuucacugauuagggagcuaaggcuccaacagcagcaaaggaa


cuaauccgccucugaucaacauggcguuucuuacagggcauuccuuauacgcuuucccacgugcguaacaggaaucgggug


uucccggguuuuguuuuguuguuguuguuuuuguuuuguuuucuuagugaaagaggcagggugggcuccaggccgcug


aggauuaauaaagagauucuaugaggaggaaauaacaggcaggugguaugaucgaggcaaggcccugaggaaggcuuggg


uggggugaguagaaccagagccggaaguccacucagcagccuggggcacuuaaagcuucugcuggggcaaaugguaaggcg


gcguaaggucacauuccuuucauuucuuccagacucaggaggagaccacaccuuccggagaaccaggccugaaccgaggua


cuauuuuguagcucucagaagccaggacucugcaacacuguuugcugccuguggaucuucuauauucacagugucccagu


ugcuucugaucuaccacuguuagauacuucugccacccauccuaagaguauaguuguucuuggaaaggagucucagcugcu


gucagcaggagucccucauucgacuccugugguugcccuuuccaccaugccaaagaauaaaggcaaaggaggcaaaaacagg


cgcagagguaaaaaugaaaaugaaucugagaaaagagaguugguguuuaaagaggaugggcaggaguaugcucaggugau


caaaaugcugggaaauggacgguuggaagcaaugugcuuugacggugugaggaggcugugccauauaagagggaagcuga


gaaagaagguuuggauaaauaccucggacauuauauugauuggucuacgagacuaucaagauaacaaagcugauguaaucu


uaaaguauaaugcagaugaagcaagaagucugaaggccuauggagaacuuccagaacaugccaaaaucaaugaaacggacac


auuugguccuggggaugaugaugaaauccaauuugaugauauuggagaugaugaugaagacauugaugacaucuagccug


accuaagcaugcuaccuuccaaguucucugaagauagcuccacacaguggcaucuugaccuucaucuguuaaguaaaacuu


cauggcauguguaugacuuguuaaugcaagcuaaugaauuuuauuuuuugaaguacuauauuucuuugaaaaccaaagau


guugaguuaucaucuuaagugacauguuaacacuuugugcuuuugaauauaauugaaccuagcgcacagcagugagcacu


guuaagagacugccuuuccauuuguagcuucauuucuggcacgggaguguuuugugucagcaguucugccagguggccau


cgaugagcugaaguaaguccuaguccagcacaucugcuucaggccuuuguacucuagucaucuggcugcguucgagacuuc


ucagcagaacuuauagauguguacggcugcacuuggagucagacaagauauggcuacuuuuguacuuauggagccaugcca


uuuuauacuuucacguuguauacauucguuugacccuuuaaguuguugccacccauaaaaaggcaucuuacagugcaguu


uuuaaauuacauggguagcaauuuugaguuuuaaaaauuagucauugcagaaauuaaauacuuagaggagauaauccauua


ucuugauuuuaggaauauaauaguugacaauguuuauauauaauuuuacuucucuaaggcauacccaaaaauagaaaauga


aaaagagcagugagucuguucugaugcuugcauugcauagagaaguuuuccaacaaagcagcuguuaauaacacauaaaau


auguuuuacuuugcaaaguagguuguguuaagucauuuucaaaaaguuaccuacuauaucgaggcucuggauaauuacua


uguguugauuaaaguuaguuacagaauuguacaagcuaaguuuuccuuaaacuaagcuuagguuaaagggagaggagcca


cagcucaaugaaaacacgguuccuguuuucuaaauggaggcgcccagaaacacaauaaaacauguugguacaaaaaaaaaaa


aaaa












57
J04596
caugaucccagccacccgcucgcuucucugugcagcgcugcugcugcuggccaccagccg




ccuggccacaggggcgccuaucgccaaugagcugcgcugucagugccugcagaccauggc




ugggauucaccucaagaacauccagagcuugaagguguugcccucagggccccacugcac




ccaaaccgaagucauagccacacucaagaauggucgcgaggcuugccuugacccugaagc




ucccuugguucagaaaauuguccaaaagaugcuaaaagguguccccaaguaacggagaaa




gaagacagacugcucugauggcaccgucuggugaacgcuggcuucugacaacacuauaca




auuucuuuugaggguccuauuuauuuauguauuuauuuauuccacaaagugugugguuu




uuauuuuacauuaauauuuaacaguguggauacauuucaucgaugguaguucaguucug




cuuguucaguuuaaagaugguaggcuuaaaauauuucauuaaaacuaauauuuauuggga




gaccacuaagugucaaccacugugcuaguagaaggguguugugcgaaaagaagugcagag




ag




auagaguuuaguauuauguuuuguauguauuagggugaggacaugugugggaggcugu




guuuguaugucuugaaaagaaugucaguuauuuauugaaagucgucuuucauauuguau




ggucaacacgcacguguugacgcuucccuuggacauuuugugucuaguugguagcccaua




augggcuuuuacauucuuuaacccuguuucuccuggucucgucucgcucgggacagagac




guucaaaggacuguuacaaaugaaguaaaaauaaaaguuuuauuaag





58
X81580
cgucucccgcauucgucugggccgugcaccugcccgcuagcucgcugcacuaccguugcc




cacaagccaacaugcugccgagauugggcggccccgcgcugccgcugcuccugccgucgu




ugcucuugcugcugcucuugggcgcgggcggcugcggccccggggugcgcgccgaggug




c




uguuccgcugcccacccugcacgcccgaggcucuggccgcuugcgggcccccacccgacg




cgcccugcgccgagcuggugcgagagcccggcugcggcugcugcuccgugugcgcacggc




aggagggcgaagcaugcggcgucuacaucccgcgcugcgcccagacgcuacgcugcuauc




ccaacccgggcuccgagcugccccugaaggcgcuugucacaggcgcggguaccugugaaa




agagacgcgugggcaccaccccacagcagguugcagacagugaugacgaccacucugagg




gaggccugguggagaaccacguggaugggaccaugaacauguugggaggugguagcagu




g




cuggccggaagccccucaagucaggcaugaaggagcuggcuguguuccgggagaagguca




augaacagcaccggcagaugggcaagggugccaaacaccucagucuggaggagcccaaga




aguugcgcccgccucccgccaggaccccuugccagcaggaguuggaccagguccuggagc




ggaucuccaccaugcgccuuccggaugaucggggcccccuggaacaucucuacucccugc




acauccccaacugugacaagcauggccgguacaaccuuaagcagugcaagaugucucuga




acggacagcgcggggagugcuggugugugaaccccaauaccgggaagcccauccagggag




cucccaccauccggggagaccccgagugccaucucuucuacaacgagcagcaggagacug




guggggcccaugcccaaagugugcaguaaaccccagccagucggugccuggcuuccccau




cccgaacaccagcagaaauggagggcgucagggugacggguguggaggaguucccaguuu




ugacacauguauuuauauuggaaagagaccaacacugagcucagaagccccccucugacc




ccccccagcggcuguuaacugaaccucccuugcuucuguuagagaggggaagggugguau




ggagggcacuggguacaggccugggaauggggaaagaaauuuuuauuuuugaaucccug




u




gucucuuuuacuuaagauuaaaggaaggaaaaauaaaaaaaaaaaaaaaa





59
AI314958
gaugugaaaaacguuuuuauuauaaucucuuaaacuuucaguguauauuuucauuacaau




cauugguacaauaaauauggaaaugcugagcagacaauuaucacaguggccuaugggcug




agggacagggacccaggaauacuguuacccuggauacuuccucagggccaaucaggaggu




cuucaaagaguauugagagggagagggauagaaauauuauuaagacugucagugcagcaa




cuuuuagaaugucuauuaaagccauggauacaggauuuacgauaacagaagauggauacu




aaaaaagaacagagacucaaguucuccuguaagaggcagaagaaacauugcagaagccag




ugccuuccucggguccccagugugugcccccauccacccacgcauuguguuggucaucuc




caccugcccugugcccagcccugugcccacccagguucuccuaggcacccaccuugcacc




ucgcacg





60
AF058798
gaauucugcgcgguuuugcauuuuuugggucagauuggcuuuuuacaugauuacgaagc




uccaacgacuagaccacagggaccgucgccuuggcggccgagcagucguauccaacuugg




a




gacagccaguucgccgugugucugucuguccuucaucgcagucauggagagagccagucu




gauccagaaggccaaguuggcugaacaggccgaacgguaugaagacauggcagcuuucau




gaagagcgccguggaaaagggcgaggagcucuccugcgaggagcgaaaccugcuuuccgu




agccuacaagaacguggugggcggccagagagcggccuggaggguccuguccagcaucga




gcagaagagcaacgaggaggggucagaagagaagggccccgaggugaaagaguaccggga




gaagguagagaccgagcucagaggugugugcgacaccguacucggccugcuggacucgca




ccucaucaaaggggcuggagaugcagagagccgcgucuucuaccugaagaugaaggguga




cuacuaccgcuaccuagccgagguggccacuggcgaugacaagaagcgcaucaucgauuc




ugcccggucagccuaccaggaggccauggacaucagcaagaaggagaugccgccuaccaa




ccccauccgccugggccuggcccugaacuuuucagucuuccacuacgagauagccaacag




ccccgaggaggccaucucgcuggccaagaccaccuucgacgaggccauggccgaccugca




cacccucagugaggacuccuacaaggacagcacccucaucaugcagcuccugagagacaa




ccugacgcuguggacagccgacagugcuggggaagaggguggugaggcuccggaugaccc




ccacaucugaagcagcggaaaaacaacccggguuggcuuggccuuccaguccccagccug




gcauagaggauuaaaagggagugggauuuugccuuucccaaacccugaauguucagcaac




accuugggaaggucuuucgaagggggcgcagccaagcugaagccaccagggcagggaauu




uaauuuuucguguagcuguuuggguggguguuucccaaaaccaucccaccccuguuuuu




u




gaacccccuccccaauucuucccccugagccucccucgggcaccuguugcuuuuggaucc




gaauaauccaggagguuccccacccuguggcugagaaauggacuguggcaagggcugugu




gugugugagagagagggaaacucugugugugugugugugagagagagagagagagugaa




ugagagggaaaaaguuugcugggugugaccaugguaccaaucaauaaaguugcccuguga




gacucaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa





61
AW046627
uuuuuuuuuuuuuuuuuaaauaccaaaacauuuaauugaaauaccuguauaaaaaauaug




aucuucagacauuucacacuuuugaacuuauacaaccccaccccugaugcuuagucacac




cagggucacagaaacacagcugcuaaaauaaauuaagggcuugagacucugucccccaac




cccagcuuucagagccagcaagcagacuguacaaggucaauaauuuaaaccccuccccag




cgcagagugcucagggugacagggucuc





62
AI848050
uuuuuuuuuuuuuuuuuaauguaacgaccggugugcuucaguuuguuuagcagaaccac




ucucuugaaucacauuaacuuuugagauuuaaaaaaaacaaaacaaaaaaaaaaaaaaaca




acaaaaaaaaaaccaacccuccauagcacagcugucuuuuaugcaagcaagagcacaccu




acuccagcaugauuugucaucuaaagacuugaaaacaaaacaacaacaacaaaaaguuac




uuauagucaauggauaagcagaguccgaauuuacacuaaucaagacagaccuucgagggg




ucacgauaaguccggaacuuucaaaccuugcuucguaugaauuguacuaucugaacauaa




acugcacuuuuauuuuc





63
AF065441
augagacuccacagccucauccugcucuccuuccuucuccuggcuacucaggcguucuca




gaaaaggucagaaagagagccaagaacgcaccacacagcacagcggaggaggggguagag




gguucagcucccucguuagggaaggcccagaauaagcagagaagcaggacaucuaaaucu




cugacgcauggcaaguuugucaccaaagaccaagccacaugcagaugggcugugacugag




gaggagcagggcaucagccugaagguccagugcacacaagccgaucaggaguuuucuugu




guuuuugcuggugacccaacugacugccuuaaacacgacaaagaccagaucuacuggaaa




cagguugcccgcacgcugcgcaaacagaaaaauaucugcaggaacgccaagagugucuug




aagaccagagugugcagaaagagauuuccagagucuaaccucaagcuggugaaccccaac




gcacguggaaacacgaagcccaggaaggagaaagcagaggucuccgcaagggagcacaac




aagguccaagaagcugucuccacggagccaaacagggucaaagaagacaucacacucaau




ccagcugcgacccagaccauggccauuagagauccagagugucuagaggauccagaugug




cucaaccagaggaagaccgcccuggaguucuguggggaaucuuggagcuccauuugcaca




uucuuccucaacauguuacaggcgacaucaugcuaa





64
AF022992
Sequence below










cgggucgacccacgcguccgcccacgcguccggcggagcuucuggguugcgggccgaaacggcaagcggauggagggcgcu


cgaacggccaggugucgugauuaaauuagucagcccucagagacaggcguccuaccuccuuuauccagaccucaaaagcccc


guugugcacccgugguggcuucuucaccuucccuguuucguccuccacuguauggcccagacaugagugguccccuagaa


ggggccgaugggggaggagaccccaggcccggagaaccuuuuuguccuggaggagucccauccccuggggccccgcagcac


cggccuuguccaggccccagccuggcugaugacacugaugcaaacagcaauggcucaaguggcaaugaguccaacggaccc


gaguccaggggcgcaucucagcggaguucucauaguuccucuucuggcaauggcaaggacucagcucugcuggagaccacu


gagagcagcaagaguacaaacucacagagcccauccccacccagcagcuccauugccuacagccuccugagugcgagcucag


agcaggacaacccaucuaccaguggcugcagcagugaacagucagcucgagccaggacccagaaagaacucaugacugcacu


ucgggagcucaaacuucgacugccaccagagcgucggggcaagggccgcucugggaccuuggccacacugcaguacgcucu


ggccugugucaagcagguucaggcuaaccaggaauauuaccagcaguggagucuggaggagggugagccuugugccaugg


acaugucuacuuacacccuggaggaauuggagcauaucacauccgaauacacacuucgaaaccaggacaccuucucuguggc


uguguccuuccugacaggccggauugucuauauuucggagcaggcagguguccugcugcguugcaaacgggauguguuuc


ggggugcccgcuucucagagcuccuggcuccccaggaugugggugucuucuauggcucuacuacaccaucucgacugccca


ccuggggcacuggcaccucugcagguucaggucucaaggacuucacccaggaaaagucugucuucugccgaaucagaggag


guccugaccgggauccagggccucgguaccagccauuccgccuaaccccauaugugaccaagauucgggucucagauggag


ccccugcacagccgugcugccuacucauugccgagcgcauccacucugguuaugaagcuccccggaucccuccugacaagag


gaucuucaccacccgacacacaccaagcugccucuuccaggauguagaugaaagggcugccccacugcuggguuaccuuccc


caggaucuccugggggcuccaguacuucucuuucuacauccugaggaccgaccccucaugcuggccauucauaagaagaua


cugcagcuggcaggccagcccuuugaccauuccccuauucgcuucugugcucggaacggggaauaugucaccauggacacc


agcugggccgguuuugugcaccccuggagccgcaagguggcuuucguguugggucgccauaaagugcgcacggcaccccu


gaaugaggacgucuucacucccccagcccccagcccagcuccgucccuggacucugauauccaggagcucucagagcagauc


caucgauugcugcugcagccugugcacagcuccagccccacggggcucuguggaguuggcccucugauguccccugguccu


cuacacagcccuggcuccuccagugauagcaaugggggggacgcugaggggccugggccuccugcuccagugacuuuccag


cagaucuguaaggaugugcaucugguaaagcaccagggacaacagcucuucauugaaucucgggccaagcccccaccccggc


cccgccuccuugcuacagguacauucaaagccaaaguccuucccugccaguccccaaaccccgaacuggagguggccccagu


uccugaccaagccucguuagccuuggccccugaggagccagagaggaaagaaaccucuggcuguuccuaccagcagaucaac


ugccuggacagcauccucagguauuuggagagcugcaacauucccaguacaaccaagcguaaaugugccuccuccuccucc


uacacugccucuucagccucugaugaugacaagcagagggcagguccaguuccugugggggccaagaaagauccgucguca


gcaaugcugucuggggagggggcaacuccucggaaggagccaguggugggaggcacccugagcccgcucgcccuggccaau


aaggcagagagcgugguguccgucaccagucaguguagcuucagcuccaccaucguccaugugggagacaagaagcccccg


gagucggacaucaucaugauggaagaccugccuggccuggccccuggcccagcccccaguccggcccccagccccacaguag


ccccugacccaaccccagaugcuuaucgcccagugggucugaccaaggccgugcugucccugcacacacagaaggaagagca


agccuuccucaaccgcuucagagaucuuggcaggcuucguggacuugacaccucuucuguggcccccucagccccuggcug


ccaccauggccccauucccccuggucgccgacaccacugccgaucuaaagcaaagcguucccgccaccaccaccaccagaccc


cccggcccgaaacucccugcuaugucucccauccuucaccugugcccucuucuggacccuggccacccccaccagccacgac


ccccuucccagcaaugguccagcccuacccacucccaguauucuccccucgaggaggaccccagccccuucccccugccccua


caucuguguccccugcuaccuucccuucucccuuagugaccccaaugguggccuuggugcucccuaacuaucuauucccua


ccccaccuaguuauccauauggggugucccaggccccuguugaggggccacccacgccugcuucccacucgcccucuccauc


ccugcccccaccaccucucagccccccccaccgcccagacuccccacuguucaacucgagaugcagcuccccacuccagcuca


aucugcugcagcuugaggaguccccccgcacggaggggggcgcugcugcaggaggcccaggaagcagugcugggccccugc


cucccagugaggagacugcugagccagaggccagauugguggagguuacugagucguccaaucaggaugcacuuucaggc


uccagcgaccugcuggagcuacugcuccaagaagacucucgcucgggcacaggcuccgcagccucaggcucccugggcucu


ggccugggcucugggucugguucaggaucccacgaagggggaagcaccucagccagcaucacccgcagcagucagagcagc


cauacaagcaaguacuuuggcagcaucgacucuuccgaggcugaagcuggggcugcucgggccaggacugagccuggggac


caggucauuaagugugugcuccaggaccccaucuggcugcucauggccaaugccgaccagcgugucaugaugacauaccag


gugccguccagggaugcagccucugugcugaagcaagaccgggagaggcuccgggccaugcagaaacagcagccacgguuc


ucagaggaccagaggcgggaacugggugcugugcacuccuggguccggaagggccagcugccucgggcccuugaugugau


ggcguguguggacuguggcagcagcguucaagauccuggccacucugaugacccgcucuucucagaacuggauggauugg


ggcuggagcccauggaagaggguggaggcgaggguggugggugugguguuggcgguggugggggugaugguggugagg


aggcccagacccaaauuggggcuaaggguucaagcucucaggacucugccauggaggaagaagagcaaggugggggcucau


ccagcccagcuuuaccugcagaagaaaacagcaccagcuagauccauuuuggggccgcuuacagcagucuaaugagaggcu


uccuuucgaccauguugggguucuuauaacucaagauacagcuggaccaaccaauaggaaacugccccagcuucucccaaca


uagggggcuggacccccauuaccagcccaggcacaggagcugccucuagcuucuuagcagaguggaaguucucagccccau


uuggaggauuguccacgcccgucccacugaggagacgggcgggucuucgguuaagguugcugacaagcugcugaaguggu


cuguccaaaucccagcugagccugagucccagucgcaggguuggggcugcacuuauuuauuugggagagacagcucacucu


cccaccucaccccaagaugggaggaggggaaccugggaucuguguaggauccagguccgugaaccccuagcugcuccaggg


ugggggagguugguggaccauggagucccuggugcugccccucaggugggacccagguguucucagcucuacccucuacc


aaugacauuuguguuuuugauauugugucuguuauuuuuuuuuuaauacaaaaugacaaaaugaaaaaccaaaaa












65
AF064088
Sequence below.










gacagcggagcgcgguggcgucgacgucuagugucucagugcucccgucuguggcuaacuaagcagccagcagccaggcag


cucgcgaccugcggccaggcagccaaccaugcucaacuucggcgcuucucuccagcaagcuucggaggggaaaauggaacu


aauuucugaaaagcccagagaggggaugcaucccugggacaaagcugagcagagugacuuugaagcgguggaagcgcucau


guccaugagcugcgacuggaagucucauuucaagaaauaccuugaaaacaggccugucacaccagugucugauaccuccga


ggaugacagcuugcuuccagggacgccugaccuucagacagucccagcauuuuguuuaacgccaccuuacagccccucuga


cuucgaacccucccaagggucaaaucugacugcaucagcgccaucuacuggccacuucaaaucuuucuccgaugcugccaag


ccuccaggcgccacuccuuucaaagaggaggaaaagaauccuuuagcugccccuccucuuccuaaggcucaagccaccagug


ucauccgucacacagcugaugcccaacugugcaaccaccaguccugccccgugaaagcagcuagcauccucaacuaucagga


caauucuuuccggagaagaacccacggaaauguugaggcuacucgaaagaacauacccugugcugcagugucaccaaacaga


uccaagccugagcccagcacaguguccgauggugaugagaaggcgggcgcugcacuauaugacuuugcugugccuuccuca


gagacaguaauuuguaggucucagccagcuccuucguccccagugcagaagucaguacuggugucuucaccuacaguaucc


acugggggagugccaccccugccugucaucugccagaugguuccccuuccugccaacaacucucuuguuagcacaguuguc


cccagcacuccuccuagccagccaccagcugucugcucaccuguguuguucaugggcacucaggugccugagggcaccguc


guguuugugguaccccagcccguugugcagagcccaaggccuccaguggugagccccaguggcaccagacugucucccauu


gccccugcuccuggauucucuccuucagcagcaagggucacuccucagauugacucguccagaguaagaagucacaucugu


agccacccaggguguggcaagacuuacuuuaaaaguucccaucugaaggcccacgugaggacacacacaggggaaaaaccuu


ucagcugcagcuggaaaggcugugaaaggagguuugcucgcuccgaugaacuguccagacaccggcggacacacacaggug


agaagaaguuugccugucccaugugugaccgucgguuuaugaggagcgaccauuuaaccaagcaugcccgacgccaccuau


cagccaagaagcugccaaacuggcaaauggaaguuagcaaguuaaaugacauugcucugccuccgaccccugcuuccgcaca


gugacggccagaagauggagacgcagaauaaacuuuggucagagucaggagccagugauggugucaagugcuucugcaag


gcuguggcccuccaaaagggccuaaaguagaagcccuggccugggggaggccccgccugggugaaaugacaagaagugcuu


cagccacaggcaggucacagaggacagggcucaguucuuaccacagagagagaggagaacccuuuuauuccucccuuauuu


uagucuggaaaguuucggcugaggugagcgcagcacagguuuugaaucacauacacauuggggacuuuguuuuugccauu


uauacuugagaccagcuuugcagugugauucuuucaaaggauugguuucaagaauauagaggcuggaaauuacgguacag


aaauggagcuagaaaaugaguuuguguuacacagagaugucaucuucuccuagaguuaucuuguuucuuauuccuagucu


uuccagucaaauccguggauguagcuaaguauaucuaaaacucauuuuuccacuauuguugguauuugaaguugaacagc


uguacauugcugugggggagccaaaggauuggaacccucauuaauuuaauugcuuggaaaugcagcuaaaauucuucuuu


ggcauuuuguuuugaaaguuuaggcauuuuacucuacuuuagauuuuaguuugcuugcaguuuuuuguguagauuugaa


aauuguauaccaauguguuuucuguaggcuuaaaauacacugcacuuuguuuagaaaaaaaucuggagaugaaaauaugua


uuauaaagaagagaugucaagaauuugagauaacuccuugagaaaguuggcuuuaugucaucagcaaaggacacuuaacgu


caagcauacacugugguuuuuuuguuuuuuuguuuuuuuuuuucaaauuagaaaguuuaaugaccguuacagauggacag


ugucuuuuuauuuauaggaguuuuucaggaugucagaguagauagguaggaaaauuguuauuagaacauucgcuucuacc


uugaaaaggauguuaauguggucauguucuuagcaccacagugucugggcaucugggaaacuccgagacuuuuuuaaagu


gucaugaugugaucacaccugcaguuuggggcaucgaauccagggccuugcaugucuucuguaagagcucucaucgcuga


ccuguaucccccgcaagagcaaugacuuuugcuaacaguauuucuuuucuguuguaaaguggacagaugauacacuugguc


gcaaagguaaauuauucaaaauccacagugaaaaccucaccacacuuucccauuuaaacuauuuccauaucucagagguuuc


ugacaugcaaacuugaacccuugaaagaagaguuuucuuaaaaauuauaaaaaaucacgaguuacaauuugcacaauauuu


uuuguugaacuuuauaccuuguuuacaauaaagacuuuucuuug












66
AI787713
uugucanuugcacgacagaaacugcaggaagaugagaugcgccgggcugcggaggagcgc




aggaggguaaaggcugaagaguuagcugccagacaaaggguucuagaaaaaauugaaagg




gacaaagcagagagagccaagaaguauggugguaguguggguucucggucauccccacca




gcaacagacccagguccuguuccuucuucucccagccaggagcccccuacuaagcgggag




uaugaccagugucguauacagguuaggcugccugaugggacuucacugacccagacuuuc




cgggcccgggaacagcuggcagcugugaggcucuacguggagcuucaccguggggagga




g




ccuggacaggaccaggacccugugcaguugcucaguggcuuccccagacgggcuuucuca




gaggcugauauggaacggccucugcaggaacugggacucgugccuucugcuguccucauu




guggccaagaagugucccagcugaggguucuccaucccaccaucuc





67
AI853531
uuuuuuuuuuuuuuuuucacaaauaaguaauauaacuuuauuaaaaugaaaagacaauau




ucaaaauaaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggag




aucagugcauuuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuu




uaaauagcucaaauaaugucauucagcaguuuaaacugaacagcuuguugggacauggca




gcagugucccugcuagcaagcaccuucucuuuguguuuaucugcacaagauaaacaauca




gaggauguaaaaacugaacacaaacugcgugucucacugaaucucagggcagugaagcag




ccagcgugaguuuucaaagcaggaagaugcugaagugaccucuggcauuaagacguucug




ugcua





68
X14678
Sequence below.










uucauuggaaagcacauugcucuucucaguaauuucuuuaguaucuucaugaauuuuuuccuuuugcgucguuauuucag


caauucuaucugcagaucauaaagguaguauugacagaugugauucuuuuucuuaaacauuucauuuccaggguaaggaac


ucaauggcuauguuuuucucucccucuagugcauccuucuccuuuucuaccauuuucacucuauuuaacuucaucauguu


cagucuggccuuuggguuucaucauagcaaucuguucaacuucacccugcaagauuaaaaaucgauuauggucuaagucaa


ugccauggcuucuaaggagauuuccaacaucuuuaaacgucuucuucuucccacuuaugugguagacagaagugcuaucuc


uguaggcgguucuggauacauagaaguugcuguuaggaaggacuucguaaucaucuccuuccuuaucaauuaucuuuuga


aaaugaacuucuacaguacaacucugaauauccuuguguucaucagaauuauguaucaguaccgauagcuuuuuagaccuu


auuuuuugugcucgauagccaaacacaaaaagcauggaaucaauaacauuggauuuuccacugccauuugguccaauaaua


caggaaaagcgcuuauggaaaggucccacaaguuucucuccagcauaggacuugaaguuuugguuuacaauaugaguuauc


augagacgaggagcuccagcuucacuggccauggcuggagguggggguggagggauacuauucaaaaucuccucuaaacu


ucuguuauccagcuccucaccuggaggcuuugcgggugcagcgcuccccucaccuacuucgccuacugcaacucccaccacc


uccucucgauacaagaccgagcucugucggaccuacucagaaagcgggcguugucgcuacggggccaagugccaguuugcu


cacggccugggugaacuucgccaagccaaucgccaccccaaguacaaaacggaacucugccacaaguucuaccuccagggcc


gcugccccuauggcucucgaugccacuucauccacaaccccaccgaggaccuagcucucccuggccagccccaugugcugcg


acaaagcaucagcuucuccggcuugccucaggccgcagaagcucgccgccaccuccaggcuuuucuggcccuucccugucc


ucuuguuccuuuucgccuuccagcuccccaccgcccccuggggaucuuccacuuuccccuucugccuucucugcugccccu


gggaccccugugacucgaagagacccuaaccaggccuguugccccuccugccgaaggucuacuacccccagcaccaucuggg


ggcccuuggguggccuggcucggagcccaucugcccacucucugggauccgauccugaugacuacgccagcagcggcagca


gccugggggggucagacucaccugucuuugaggcagggguguuugggccuccccagaccccugcacccccaaggcgucucc


ccaucuucaaucguaucucugucucugagugacaagugccuaccuacccaguauggaucagcuagaucucaaagagagggc


agggacugcucauugcuguggggaccuggggcacuccucuaaguuaauaagucccaucuucuggacauuccaagaugcaau


aacccauuucccuggugcugggcuggggcaggucccuaguuugcaaauucaguguuuggguggauccguuccuaggguac


cuaagauguuugagggagacaguugacaguuggucuuccaggccccaagucuucuguuguuuuugagauaggagcuuauu


augguaccccaggcuggcuuugaacucaauauaauccugccuuagccuuuuccaaguucugggguuacagguaugcaccag


ccccucugcaacucuggucuccuggaaucuuaagugcugugaagagccggcucccacaauacuauccuaauuuuuacuaga


cccugaaguucaguguccgguggucgaagccucuccugagaauccuggugcucaaauuucccuccuaaagcaaauagccaa


agccauugccaaaucccuucucccccaaccagugggcccuuuauuuaugacgacuuuauuuauuguauuaagauuuuauag


uauuuauauauauugggucgucuacuccguuuuucuuuuuguaauguuaaaacugauacuguauuaaguauaugcuauaa


uauauuaauauauugcu












69
AI854358
cggacgcugcagaccugaccgacgugcugugcgaguucgacgcggugcuggccgacuucg




cgucgcccuuccacgagcgcacuuccacuaugaggagcaccuagagcgcaugaagcggcg




cagcagcgccagcgucagcgacagcagcggcuucagcgacucggagagugcagacucagu




guacagggacagcuucaccuucagugaugagaagcugaauucuccaaccaacuccucucc




agcucuccugcccuccgcugucacuccucggaaagccaaauuaggugacacuaaagagcu




cgaagacuucauugccgaucuggacaggaccuuagcauguaugugaagcaaggaguuugg




gguc





70
X67668
ccgggccgaggagaagucugcaaaacaagaggcuggggauugccuuagcgagaaaucagu




ucucuuaggagguuagggaaggaagucuuucucuggaggucugagggaagcgcucgugu




c




agaugccggguugucauggguaagggugaccccaucaagccgcugggcaaaauguccucu




uacgccuuuuuugugcagaccugccgggaggagcacaagaagaagcaucccaauucgucg




gucaacuucgccgagaucuccaagaaaugcuccaagagauggaagaccaugucugcaaag




gaaaacucgaaguuugaagauuuggccaagagcgacaaagcuuguuauuacagggagaug




aagaacuauguuucucccaaaggugauaagaaaggaaagaaaaaagauccaaaugcuccg




aagagaccaccgucugccuucugccuguuuugcucugaaaaucgcccaaagaucaaaauu




gaauacccgggccugucuauuggagauacugcgaagaaacugggugagauguggucuga




g




cagucugccaaagagaaacaaccguaugagcagaaagcagcuaaacuaaaggagaaguau




gaaaaggauuuugcugcauaccgugucaagggcaaaagugaagcaggaaagaaggguccu




gguaggccagcaggcucaaagaagaaugacucagaagaugaggaagaagaagaggaggaa




gaugaagagggggaagaagaggaugaagaauaaguggcuauccuaaaguguggaguauau




gugcucaggcaguuauuuugcuaagaauguaaauucaagcgcagcucaacauuagcucca




guaggaa





71
K02236
aucacgcuccuagaacucuucaaaccgaucucucgucgaucuucaa




ccgccgccuccacucgccauggaccccaacugcuccugugccuccgguaagggggacugc




ugacgggauuucugggagagcuagacaggcuuuuuggccccuccuuuaguaauuacuuu




a




aggguacgaccggcuaccccuuccgaaugaauucugaagcacuccugcuccuuuaaacua




guccuugagauaguggcucgccuacccgggugauuugccucaccuuccuaggagaacagc




guucagguacucccgggucccacucaaccgcgcucacugacugccuucuacuuuuagaug




gauccugcuccugcgcuggcgccugcaaaugcaaacaaugcaaauguacuuccugcaaga




aaaguaaguuggaucuucucugccauuuccccgucacucuccuggggucccuagcccgcc




gcgccgcgccuucccucccgggagcguucagguggugugccucugacaagguuucucgcu




cacguucaacucuucucuccccacaggcugcugcuccugcugccccgugggcugugcgaa




gugcucccagggcugcaucugcaaagaggcuuccgacaagugcagcugcugugccugaag




gggggcggagggguccccacaucuguguaaauagaccauguagaagccuagccuuuuuug




uacaacccugacucguucuccauaacuuuuucuauaaagcauguaacugacaauaaaagc




cguugacuugauu





72
X51829
Sequence below.










gcucugaguuuguggaagauuacaugcgauaucccgcgcgaccccgcaucccuuugccggccgggacagccuuugcuacag


ccugugaaacauugcguccccgagccccacgccugagggcgacaugaacccgcuggcuucgcgagcaguccggacccacgau


cgcuuuuggcaaccagaaccggcgcuucagcccccggggugacgugcagcccgccgcccagacacauggccccgagcccaag


accccagcauguccugcacuggagggacgcccacaacuucuaucuccuguccccacugaugggcuugcucagucgggccug


gagccgccugaggggcccagaagucccagaggcauggcuggcaaaaacaguaacaggagcagaucagauagaagcugcggc


ucugcugacaccuaccccugucucugguaaccuccucccucauggggagacugaagaaaguggaucuccugaacagaguca


agcagcccagaggcucugccuuguggaagcugaaaguuccccuccugaaacuuggggacuuucaaauguugaugaguacaa


ugcaaagccaggacaagaugaccuuagagagaaggaaauggaacgcacagcuggcaaggccacacuacagcccgcuggccug


caaggggcugauaagaggcuuggggaggugguggcuagagaagagggaguggcugagcccgcuuaucccacaucacagcu


ggagggugguccagcugagaaugaagaggauggagaaacagugaagacuuaccaagcuucugcugcuuccauagcuccggg


auacaaacccagcaccccugugccuuucuugggggaggcagaacaucaagccacggaagaaaaaggaacagaaaacaaggcu


gaccccuccaacucuccuucuucaggcucccacuccagagccugggaguacuacucuagagagaagccuaagcaggagggag


aagccaagguagaggcacacagggcagggcagggucacccuugucggaaugcugaggcugaggaaggaggaccugagacaa


cuuuugucuguacuggaaaugccuuccugaaggccuggguguaucgcccaggagaggacacagaggaagaagacaacagcg


auucggauucagcugaggaagacacagcucagaccggugccaccccccauacaagugccuuccugaaggccuggguguauc


gcccaggagaggacacagaggaagaagacagcgauucggauucagcugaggaagacacagcucagaccggugccacccccca


uacaagugccuuccugaaggccuggguguaucgcccaggagaggacacagaggaagaaaacagcgauuuggauucagcuga


ggaagacacagcucagaccggugccaccccccauacaagugccuuccugaaggccuggguguaucgcccaggagaggacaca


gaggaagaaaacagcgauuuggauucagcugaggaagacacagcucagaccggugccaccccacauacaagucccuuccuga


aggccuggguguaucgcccaggagaggacacagaagaugacacagaagaggaagaggacagugagaauguggccccaggug


acucagaaacagcugacucaagccagagucccugccuucagccccagcguugucuaccaggagagaagaccaagggacgugg


ggaagagcccccucucuuccagguggccuucuauuuacccggagagaagccagaaucaccuugggcugcaccuaagcugcc


ccuucgacugcagaggcggcucagauuguucaaagcccccacccgggaucaggaccccgagauuccucuaaaagcucggaag


guacacuucgcugagaaagucacaguccauuuccuugcugucugggcaggaccagcccaagcugcccgucgaggucccugg


gagcaguuugcacgagaucgaagccgcuuugcucgacgcauugcccaggcagaggagaagcugggucccuaccuuaccccu


gauuccagggccagagcaugggcacgccuuagaaacccaucucuuccacaguccgagccucgcucuuccucugaggccacuc


ccuugacccaagaugugaccacacccucuccccuucccagugaaaccccuucgcccagccuguacuugggagggaggcggg


gcuaagccugaguaguuuccuauuauuuauuuauuuauuuauuugaauaagaaauaaagccuuuuaauuuguagugau












73
AW048937
uuuuuuuuuuuuuuuuuaaucaucgagaaguauuuauugagcaccagcuuuggggucgg




gugugaggacucgggacaaugcagggugcugucccuucucgugagacgcuuacaaucuga




guggagacagggagggagccacaauacauguucuuggggugcgggcuaaggguagacag




uccagaccaggauguuacagaaacagggauguuuggggcuggagucagacccacuaagug




cu




uugacacccacgguauucaacacugagaaaggaucagccauugcucaguguccugugagc




ucccuuagcccccaagacaccaucuuggccuggcuccuuguacaacugcuacuaa





74
AV139913
cccaaaacccauucagcaaaguucccaaccucgacgggcuagcaguauuuaaccagugau




ggguucacuguuguauuuggugaauacuguauuuuguuucaguucuuucucccagauaa




uuugaaaacguuccaggagaaggcagcuuccuauaugcagcgugugcuuucuuauucuu




uuuuuuaauauaugacaguuauuugagaacccauuucuacuuugaauucauuuucguug




aaagugauguuucuucaccuaccauuuuccuauuaaaguucuguauucaaau





75
M32490
Sequence below.










agaccgugagcgagagcgccccagagaagcgccugcaaucucugcgccuccuccgccagcaccucgagagaaggacacccgc


cgccucggcccucgccucaccgcacuccgggcgcauuugaucccgcugcucgccggcuuguugguucugugucgccgcgcu


cgccccgguuccuccugcgcgccacaaugagcuccagcaccuucaggacgcucgcugucgccgucacccuucuccacuugac


cagacuggcgcucuccaccugccccgccgccugccacugcccucuggaggcacccaagugcgccccgggagucggguuggu


ccgggacggcugcggcugcuguaaggucugcgcuaaacaacucaacgaggacugcagcaaaacucagcccugcgaccacacc


aagggguuggaaugcaauuucggcgccagcuccaccgcucugaaagggaucugcagagcucagucagaaggcagacccugu


gaauauaacuccagaaucuaccaaaacggggaaagcuuccagcccaacuguaaacaccagugcacauguauugauggcgccg


ugggcugcauuccucuguguccccaagaacugucucuccccaaucugggcugucccaacccccggcuggugaaagucagcg


ggcagugcugugaagaguggguuugugaugaagacagcauuaaggacucccuggacgaccaggaugaccuccucggacuc


gaugccucggagguggaguuaacgagaaacaaugaguuaaucgcaauuggaaaaggcagcucacugaagaggcuuccuguc


uuuggcaccgaaccgcgaguucuuuucaacccucugcacgcccauggccagaaaugcaucguucagaccacgucuuggucc


cagugcuccaagagcugcggaacuggcaucuccacacgaguuaccaaugacaacccagagugccgccuggugaaagagaccc


ggaucugugaagugcguccuuguggacaaccaguguacagcagccuaaaaaagggcaagaaaugcagcaagaccaagaaauc


cccagaaccagucagauuuacuuaugcaggaugcuccagugucaagaaauaccggcccaaauacugcggcuccugcguaga


uggccggugcugcacaccucugcagaccagaacugugaagaugcgguuccgaugcgaagauggagagauguuuuccaagaa


ugucaugaugauccaguccugcaaauguaacuacaacugcccgcaucccaacgaggcaucguuccgacuguacagccuauuc


aaugacauccacaaguucagggacuaagugccuccaggguuccuagugugggcuggacagaggagaagcgcaagcaucaug


gagacgugggugggcggaggaugaauggugccuugcucauucuugaguagcauuaggguauuucaaaacugccaaggggc


ugauguggacggacagcagcgcagccgcaguuggagaaugccaaggggcugauguggacggacagcagcgcagccgcaguu


ggagaagacuucgcuucauaguacuggagcgggcauuauugcuccauauuggagcauguuuacggaugacguucuguuuu


cuguuuguaaauuauuugcuaaguguauuuuuuugcuccagacccccccccccuuucuugguucuacaauuguaauagag


acaaaauaagauuaguugggccaagugaaagcccugcuuguccuuugacagaaguaaaugaaagcgccucucauuccuucc


cgagcggagggggacacucugugaguguccuuggggcagcuaccugcacucuaaaacugcaaacagaaaccagguguuuua


agauugaauguuuuuuuauuuaucaaaguguagcuuuuggggagggaggggaaauguaauacuggaauaauuuguaaau


gauuuuaauuuuauaucagugaagagaauuuauuuauaaaauuaaucauuuaauaaagaaauauuuaccuaaa












76
AI121305
ccaauaccacagccgugaccacagccaagaccacagccaaaagccuggccauccgcacuc




ucggcagcccccuggcagugcccuccauauccugcuuguuuuucucauuaguaaacuccu




cuucuaaagaaaacuggggaagcagaucuccaaccuccaggucauccucccgagcucauu




ucaggccagugcuuaaacauacccgaaugaagguuuuauguccucaguccgcagcuccac




caccuuggaccacagaccugcaacacuagugcacuugagggauacaaaugcuugccugga




ucuuucagggcacaaauuccgcuucuuguaaauacuuaguccauccauccugcgugua





77
U35374
auggagaacgaguucacauacgaagauuaugagaccacugccaaguggcuucugcaacac




acugaauaucgaccucaaguggcagugaucugugguuccggcuuaggagggcugacugc




u




cacuuaaaggaggcucagaucuuugacuacaaugagauacccaacuuuccccaaagcaca




gugcaaggucacgcaggccgacugguguuuggauugcugaauggcagaugcugugugau




g




augcaaggccgguuccauauguaugaaggauacucacugucaaaggugacauucccagug




agaguuuuccaucuucuggguguggaaacuuugguggucaccaaugcugcuggaggacu




c




aaccccaauuuugaaguuggagauauuaugcugauccgugaucacaucaaccuaccuggu




uucuguggccagaacccucuccggggccccaacgaugaaagguuuggaguucguuuuccu




gccaugucugaugcuuaugaccgggauaugaggcagaaggcuuucagugccuggaaacaa




augggggagcaacgaaagcuacaagaaggcaccuacgugauguuggcaggccccaacuuu




gagacuguggcagagagucgucugcuaaagaugcugggggcagaugcuguuggcaugag




c




acagucccagaaguuaucgucgcaaggcacugugggcuccgugucuuugguuucucacuc




auuacgaacaagguugucauggauuaugagaacuuggagaaggccaaucacauggaaguu




cuggaugccgggaaagcagcugcacagacauuggaaagguuugucuccauucuuauggag




agcauuccacucccggaucguggcagcuga





78
X15643
Sequence below.










uuccaggacagcuggggcuccacgagagaaacccugccucccccccaaaaauggcccaaaguucacugacaaacucacauuu


gucugauauuuagcuauguaacagcacuuacgguagcaauagaauuugauucucacucaucacaaugaaaauggcuggcgc


ucucucucucccucucuccccauuucaaaucugcaagcacaccccuuagagauggagagaauuugauccauuggagaaucg


agcuaaaaauaccaccauggaauugugggaaggauuaaaugcaauaaugcacaaaaggcacauagcagaaugugcccuaaau


gucagccauuguuaugguauuauguaaucuacaaaguauguuugcuuacuccgugugaaagacuuucagucuaucaaaca


uaauacaugugaaaucaaaccuugaaaauuaauuuuuuucccaacagucaagacauuugccagcugcagagauuagcauuu


caugaaucuuagucuugucugauuuuuuuaaugggaaggaacaacuauccucaacuauccuuuuuuuuuuucuguaguuu


uaaaaugaacuccacaaaacauguuuuuaauauagggaauuauaugaaauuguggggugggcagcgagguuaaaggcagaa


auagcccaaugguggcacauucacugacacagccuaaaagauuagcaaauuacccagccaacacauacaauuaauacaauuaa


uauuuuuauaguuaaaacagaguuacuaaagaaauuguuugaaaagaaaauuaugaagacuggaaagacggcucagugcuu


aagagcuuuggcuagucuuccagagaaccagggucauccagcacucacaaggcagcuugugagcugauacuaucuguauau


ucaguccuagggaaucugaugcuuuguccugaccuccaaaacaggcacaaauguggugcacaggcaaauguagagauaaga


cucccaugcacagaacauaaauaacguaguuuaauuuuuuaaauuguaaaacugaaaaugguugcacuugcauuuuuauuu


ucagcacauccccagauauccgccauauaacaagaaaaugaugccacacucccaagaauuaagaauuacaccucccaacccua


cccaaauguguauacucuaggucuaaagaaaugcaaaggaugaaguuacugccuugugcgguucucaaggagggaggaugc


caaaaaaauauuuuuucacaaagugugcugagaaacucuguagcuguuggagucaucuccugugcucuugccaaauaacug


aaaggggauacacuggaugucugugaauggggugucacuuaugagugcuagaagcggguaccuggauguggacacggugu


cugagugguccgcacuccaugucuccacaggagcgcuuauguguguuucuuuccuccugcuucuggguguuccuggguuu


guuuacagccaccucucuguuggaccaggagacagcugucgucuccagaaugagcgggcacgggugugucucgguggcug


uggcugugguucggcauaagucugagcauguccuggucgucagggugcguuugugcugugugugcguguccgggugagc


uugcucuuucuguuccuaaaagaaaaugcacccugcgcuaccggcguccagagacucucagcccgcagaggugaccugaac


ggacagguagcaccuccagacagcgccugguuggcggguugcacagcagccccagauuucucucucuggugccccagcuag


gguagcuggaagggagcgguggccuggccuccggggagccgcugggccccgccgggcuaacccaggaggaggccggcuag


gcugggaggguuagcccuuggugcccuacgccugcccgggccagucgcggccgccggccauuggcccaaagaauuguugca


cgucacuggcaauuccccuagaagucugugcacauaacgggcagggcgcacugcaaggcugcuucucccgcauuuaggcug


cggcugcaggcaccgcgagcccggagcacccacgagcuuagugugcaggacgcaccccagcacagccaccuacggccgcuga


augaagcuuccaggaguccgcccccggccgucgccccgucggaggugcacccgcugagagcgccuggaccgaaaggccggu


gcgcucaccugcuaaccugccagccauggggccacacgggaacgacagcgacuucuugcuggcacccaacggaagccgagcg


ccacaccacgacgucacucaggaacgggacgaagcguggguugugggcauggccauccucaugucgguuaucguccuggcc


aucguguuuggcaacgugcuggucaucacagccauugccaaguucgagcgacuacaaaccgucaccaacuacuucauaauc


uccuuggcgugugcugaucuagucaugggccuagcgguggugccguuuggggccagucacaccucuaugaaaauguggaa


uuuuggcaacuucuggugcgaguucuggacuuccauugauguguugugcgucacagccagcaucgagacccugugcguga


uugcaguggaucgcuauguugcuaucacaucgcccuucaaguaccagagccugcugaccaagaauaaggcccgagugguca


uccugaugguauggauuguaucuggccuuaccuccuuuuugccuauccagaugcacugguaccgugccacccacaagaaag


cuaucgauuguuacaccgaggagacuugcugugacuucuucacgaaccaggccuacgccaucgcguccucgauugugucuu


ucuacgugccccugguggugauggucuuugucuauucccgggucuuccagguggccaaaaggcagcugcagaagauagac


aaaucugaaggaagauuccacgcccaaaaccucagccagguggagcaggaugggcggacgggccacggacuccgaaggucc


uccaaguucugcuugaaagagcacaaagcccucaagacuuuaggcaucaucaugggcacauucacccucugcuggcugccc


uucuucauugucaauaucgugcacguuaucagggacaaccucaucccuaaggaaguuuacauucuccuuaacugguugggc


uacgucaacucugccuucaauccucuuaucuacugucggaguccagauuucaggauugccuuucaagagcuucugugccuu


cgcaggucuuccuucgaaaccuaugggaacggcuacucuagcaauagcaacggcagaacggacuacacaggggagccaaaca


cuugucagcuggggcaggagagagaacaggaacugcugugugaggaucccccaggcauggaaggcuuugugaacugucaa


gguacugugccuagccuuagcguugacucccaaggaaggaacuguaguacaaaugacucgccacuguaauacaggcuuucu


acucucuaagaccccuccuugacaggacacuaaccagacuauuuaacuugaguguaauaacuuuagaauaaaauuguauaga


gauuugcagaagggggggcacauccuucucgccuuuuuuuaauuuuuauuuuauuuuuuagcugcaaacaagagagagaa


cuguauuugagugcuuauuguucuuguauaguucaguuccucuuguauggaacuuaaagguuucugucugaagaguguu


gguucugaggacugagucugucugucugucugucugucugucugucuggaugauguuuucauguaucuaccucacuggu


caaguauuaagaaugauauauauugcugcuggaaauccauaucuaaaggagagaguuuucuuccuguacccuuggacuuga


aauauccugugucuuggaccuuucugcugugacaaugggcccuuucucucucacuccacuuauuuacucaaauggauucga


ggcagggauuugagggacaacacuaguuguuuuguuuuuguuuuuguuuuuuuguuuguuugguucguuuuugguuug


uuguuguuuuuugggguuuguuuuuguuuuuguuuuuuuggguuuuuuuuuuuugcugagaaaagucuaaaguuuaca


guaaauaaauuguuuaaccaugacuucauugcacccguuucuucaaaaccucuugacucuggaguguccuugucucuccca


cuggaaaccacagguaaacuaugugucgugaccgaugaguggcuuaauguguaagaguaccagaauggcaugcuugcaugc


accgugccuagcccuuccgugugugucuucagagcuccagaugcaaaccugugccuucccuaacuucacucgugucccaaa


gcaguccugccuguucacagcauaacccaguauguccuacaguugcucuucugugcugucacuccagaaacccugacucac


ggaaacagaguuauggacauauguuuuuguccccauaugcucugacaccaccuucagccuuacuugcuuaauaacugugua


uauuuacaucacugcgucucuuacaguagugccuuuguacugcaucagggcuugguguguucaggaugaggaagauguuc


uguguaauagcuguucaagcaucuagaaauucugagggaaaucaaaggccucggucagagagagagagagagagcaaagcu


uuaaaaaacauagcuggugaaugcuucacgcccuucagccucuccucgcuccgucugcugucccgugucuucuguucccaa


uucucugcacuucuguguaaaccaggcuucccaugucuggcauuccgugcauuauaugauauuuggcggcacgucuguac


caguaaauucugguagcacccccuaguuacaauaauugcagacacucagcgcguacgacccccuaguuacauaugcagacac


u












79
AI849109
uuuuuuuuuuuuuuuuuaagcguccaggcuguacuuuauuuuacacaagugguggcccc




agaaccacagggacaugaccuggagaguaggcacagugccugaggcugcaagagccaaaua




cagggauucaugccuucuccuugguccccaugaccaaauuaaaaaaaaaaaaaacaacaa




aucacacagcacacaucgccacacccauccccuccuuccuuucagcaacagccaauucag




cuuucuagccaaagacaguggcuacaacugaauuuacagagaaccaugcagccaagaaac




cagagccacggaggggagaggcuugcguugacuucccacaugugcugucccauagcagcu




gagugaccccacca





80
U70132
agaaagauaagggccagcaaggaaagaaugaggaugugggcgccgaggacccguccaaga




agaagcggcaacgccggcagaggacucauuucacuagccagcagcugcaggagcuggaag




ccacuuuccagagaaaccgcuacccagacauguccacucgcgaagaaaucgccgugugga




ccaaccuuacggaagcccgaguccggguuugguucaagaaucgccgggccaaauggagaa




agcgggaacgcaaccagcaggccgagcugugcaagaauggcuuugggccgcaguucaacg




ggcucaugcagcccuacgaugacauguaccccggcuauucguacaacaauugggcugcca




agggccucacgucagcgucucuguccaccaagagcuuccccuucuucaacuccaugaacg




ucaauccccuguccucucagaguauguuuuccccgcccaacuccaucucaucuaugagua




ugucguccagcauggugcccuccgcggugaccggcgucccgggcuccagccucaauagcc




ugaauaacuugaacaaccugagcagcccgucgcugaauuccgcggugcccacgcccgccu




guccuuacgcgccgccgacuccuccguacguuuauagggacacauguaacucgagccugg




ccagccugagacugaaagcaaagcagcacuccagcuucggcuacgccagcgugcagaacc




cggccuccaaccugagugcuugccaguaugcagucgaccggccggugugaaccgcgccca




gggcgcggggauccgaggacugucggagugggcaacucugccccagaaagacugagaauu




gugcuagaaguucgugcgcacuaugggaaggaagaggggggaaaaaagaucagaggaaaa




gaaaccacugaauucaaagagagagcgccuuugauuucaaaggaauguccccaagugucu




acgucuuucgcuaagaguauucccaacaguuggaggacgcguacgcccacaaauguuuga




cuggauaugacauuuuaacauuacuauaagcuuguuauuuuuuaaguuuagcauuguua




a




cauuaaaaugacugaaaggauguauauauaucgaaaugucaaauuaauuuuauaaaagca




guuguuaguacuaucacuacaguguuuuuaaaggcuaggcuuuaaaauaaagcauguuau




acagaaucaguuaggauuuuucgcuugcgagcaaaggaauguauauacuaaaugccacac




uguauguuucuaacauauuauuauu





81
M13805
cugagaggccaggugggcggcgaaaucaacguggagauggaugccgcucccgguguggac




cugagccgcauccugucagagaugcgugaucaguacgagaagauggcggagaagaaccgc




aaggaugccgaagacugguucuucagcaagaccgaggagcugaaccgcgagguggccacc




aacagcgagcuggugcagagcggcaagagcgagaucuccgagcucaggcgcaccaugcag




gcccuggagauugagcugcagucccagcucagcaugaaagcaucucuggagggcagccug




gcagagacagagaaccgcuacugcgugcagcugucucagauccaggggcugaucggcagu




guggaggagcagcuggcucagcugcgcugcgagauggagcagcagaaccaggaguacaag




auccugcuggaugugaagacaaggcuggagcaggagaucgccaccuaccgccgucugcug




gagggagaggaugcccaccugacucaguacaagccaaaagaaccugugaccacccgccag




gugcgcaccauuguggaagaaguucaggauggcaaggucaucucaucccgggaacaggug




caccagaccacccguuaaggacucagcuccuuccgcccaguuccccgaggcugcagagag




gcagcuucccucuccgcuccggcaucacccuccugcuacagccucuccccagcauuccua




ugcuugagaccauuaaagcuugcugaccugaagugaacuguggccuuuguucugaacacu




gaaauaaaugaccauggugac





82
AV138783
ccccaggggugaaaugaggauucccccacccugcggaacagugaaauguguauaauuaag




aggagggcgacgacccuugccgcgggacccgggacucgagcccgggacuucgcagcuaca




gcaaaucuauuuuuaauauugugcugagcaagacagaucgcuugcauauuuuuaaaaauu




uuuacuacagagacauuccaauaaauucguuaagcc





83
K02927
Sequence below.










cugacagucgucucugucccuucuucgccucggagcugcuaacuggucucgaaccucucagcacuucagcuucuagcggcg


augcaugugaucaagcgagauggccgccaagagcgaguuauguuugacaaaauuacaucacgaauccagaaacucuguuau


ggacucaacauggacuuuguugauccugcucagaucaccaugaaaguaauccaaggccuauauaguggggucaccacagug


gaacuggacacccuggcugcugagacagccgcgaccuugaccacgaagcacccugacuaugccauccuggcagcaaggauag


ccgucucuaacuugcacaaagaaacaaagaaaguguucagugaugugauggaggaucucuacaacuacauaaauccgcacaa


cggcagacacucucccaugguggccagcucaacacucgacauuguuauggccaauaaggaucgccugaauucugccauuau


cuaugaccgagauuucucuuauaacuacuuuggcuuuaagacacuggaacggucauauuuguugaagaucaaugguaaag


uggcugaaagaccacagcauauguugaugaggguuucuguggggauucacaaagaagauauugaugcugcaauugaaacc


uacaaccuacuuucugagaagugguucacucaugccccuccuacucucuucaaugcugggaccaaccgcccacagcugucua


gcuguuuccucuugaguaugaaagaugacagcauugaaggaauuuaugauacucugaagcagugugccuugauuucuaag


uccgcugggggaauugguguugcugugaguuguauucgggccacugguagcuacaucgcugggacuaauggcaauucuaa


uggccuugugccaaugcugagaguauauaacaacacagcucgcuauguggaucaagguggaaacaagcgcccaggcgcguu


ugcuauuuaccuggagccuuggcacuuagacaucuuugaguuccuugacuugaagaagaacacaggcaaggaagaacagcg


agcacgcgaucucuucuuugcacuuuggaucccagaucucuucaugaagcgaguggagacuaaccaggacuggucauugau


gugucccaaugaguguccuggucuggacgaggucuggggagaggaguuugagaaguuauaugaaaguuacgagaagcagg


gucguguccgaaaaguuguaaaagcucagcagcuuugguaugccaucauugagucccagacggagaccgguaccccauaca


ugcucuacaaagauuccuguaaccggaagagcaaccagcagaaccugggaaccaucaaaugcagcaaccuguguacagaaau


aguagaguacaccaguaaagaugagguugcaguuuguaacuuggcuucucuggcucugaauauguaugucacaccggaaca


uacguaugacuuugagaaacuggcagaagucacuaaagucauuguccgaaaucugaauaaaauaauugauauaaacuacua


cccuauuccagaggcacacuuaucaaacaaacgccaucggcccauuggaauugggguacaagguuuagcagaugcuuucau


ccugaugagauaccccuuugagagcccagaagcccaguuauuaaauaagcagaucuuugaaaccauuuacuauggagcccu


ggaagccagcugugaacuagccaaggaguauggccccuaugaaacguaugagggaucuccagucagcaaggguauucuuca


guaugacauguggaauguugcuccuacagaccugugggacuggaagccucucaaggagaagauugcaaaguaugguauaa


ggaacaguuuacuuauugccccaaugccuacugcuucaacugcccagauucuggggaauaaugaguccauugagccuuaua


ccaguaacaucuacacucgaagagucuugucaggggaauuucagauugugaauccucacuuacugaaagaucuuacugagc


ggggcuuguggaaugagagaugaaaaaucagauuauugcaugcaauggcuccauucagagcauaccagaaauuccugauga


ccugaagcaacucuauaagaccgugugggaaaucucucagaagacuguucucaagauggcagccgagagaggugcuuucau


cgaucagagccagucuuuaaacauccauauugcugagcccaacuauggcaaacucacuaguaugcacuucuacgguuggaa


gcaggguuuaaagacuggaauguauuacuuaaggacgaggccugccgcuaauccaauccaguucacucugaacaaggaaaa


acugaaagauaaggaaaaggcacugaaggaggaggaggagaaggagaggaacacagcagccauggugugcucuuuggagaa


cagagaggagugccugauguguggauccugagaaaagcggggccugggagacgcagcgggcucuccugcccgagaggcag


acgauuugagcauagauaggauaguggguuugcuugguuaucagcagcucugcuuggacgugccugccaggacagggagc


cacgacuuacaguacuguuucuacacaguguaaauaucauuuuuaacaaacagaaaaccaaagccagcuuugauauuaggaa


ucaagguagaggcuuugggaauacuaaagagccuuccugcaaauagugaggagacuuaggaagucucgucucuccagcuuu


cccugccuggccauucucaguuugggcaaagagauuuaguuugauuugacugauugccuagaaguaaaaucaagcaauuac


ucaucagcuaaagaccuuugucuagacaaacuucuauaagucauuuugaaauaaacauuucuaagugau












84
X07699
Sequence below.










uugccucagacgcuagcuguagcuggcaggcgguuguacgugcuccagagucgucgguacccgcuacugcagucgcuuuc


guguggcuuccgcugagcucuuccgagcugcucgcucuccacacgcgccgccgccguaauccgccaccauggugaagcucg


caaagguaagaggccuuggcgcgccgacgcggacgacuaggccccugcuuucggagggacgcgcgcgcgcccgcccguccg


ucgcggaggggaggagggcuugcgcgcaaucccgggcgcguucgagggcgccaugcugggggggaaagucucgcgcgacu


agcgggaggucucgcggugcuugcccucugacuuagggggaugagaagagcggaggcagguuuccgggagggcgauaucg


aggguucggauguagcgggcgggaggggacggugugaggagagaucggaggagcugagagcggauaggggcacggcgug


ggaagagagggccaaccuuaggcggcgagcggucccggggccccgccuccccgcgcacgugcucuggugcgcgcccgccac


gugcucugcggagccccgcacgugucgcgcgacccggggcagugggggagugucuguaguaccccggaaagggggacggc


agcguggggauggauggguggcccggcgaucugcugucucugccggugaccgggauggacacgugguggaccccugaggu


ggcggcguggugacuccacgugguggggcuggaagcgagagaaagugggaagcaguuggguuacguggugcugcuuuaa


gaggugauuucgagauacccccuuccccagcaaauaacuuaaagggaucccuuuaacuggguuuuuuuuuuuuuuuuuuu


uuuuuuuuuuguggaagaugccagaaaauagauggccaggauuaggagacuuuauaaccuguggcuguuucuuggugua


gaguucugucugcucaguuaucugugagaaggaaaaaaaaauuaugcgcgguucgcagaaaaaacugccaggagaaugcca


ugccuggccaagaagaagucuuuaugcuuguguccuuuaguaagaaaaaggugguggccaaaggcaaagugacugaaaaug


cgugcaauuuuugugugcguuuguaggcuggcaaaacccacggugaggccaagaaaauggcuccuccuccaaaggaggug


gaagaggauagugaagaugaagaaaugucagaagaugaagaugacagcaguggagaagaggagguaagaagcuauuugcag


cgaauuaaaccgguggaauugaaugucuggaagucuuagaaauacaggauauguaguaaaugguugaauggcaagccccuu


ccucccucccucccucccucccucccucccucccucccucccuuccuuccuuccuuccuuccuuccuuccuuccuucugcaa


gacagucggcaaaacaggggacagaaacaggcagaauuuugaguuccaggcaagcagggaguaguacauagugaaaccuug


ucucaagaccguuguuauggucaugcucaaucagauuucuuagaaaagcucaggugcugaguccaguuuuuuuuuuuuua


aaguauugaaagccaugucuccuuauuucaggguuuaauguuuaucuuugugugugcgcgcacccauuaagcaugcuugg


uacccucauacuagaauguacuuggauccccuggaacuggaguuaaagccacaugugaauguuacauguuacaagaguaac


acaugugcuuaacuuuugagucaucucuccaguucuugguuguuuguuuuuuuuuuuuuaagccuaucuaauguccauu


uucuugugcucaaaguuagucucuuaauguagcauuggguauaaaggaaugcuuaugauuuguuugcuuucaagguugu


caucccucagaaaaaaggcaaaaaggcuaccacaaccccagcaaagaaggugguuguuucacaaacaaaaaaggcugcaguu


cccacaccagcuaagaaagcagcugugaccccaggcaaaaaggcaguagccacaccagcuaagaaaaacauuacaccagccaa


agucauuccaacaccggguaagaagggagcugcacaagcaaaagcguugguaccaacuccugguaaaaagggagcugccacu


ccagcuaagggggcuaagaacgguaagaaugccaagaaggaagacagugaugaggaugaagaugaagaggaugaagaugau


agcgaugaggaugaagaugaugaggaagaggaugaguuugagccaccaauaguaaaaggagugaagccagcaaaagcagcu


ccugcugcuccugccucagaggaugaggaagaugaugaggaugaagaugaugaggaagaugaugaugaagaggaggaaga


uggugaguuagaucuuaggauauuuaggguacugcauguacauucccucacuguuucauuagauuaaaaacucauuuugu


gcucuuaguucuuuccauaacuuaauagguuuucauuugcuaaguaguuuuuguuuuuuuuaaguauuuguagcauuua


ucuugucuggauugguagguagcaaauacauuugccugauuugccaucuuucuuccagacucugaggaagaaguuaugga


gaucacaacagccaaaggaaagaaaacuccugcaaaaguuguuccuaugaaagccaagaguguggcugaggaggaggauga


ugaggaagaggaugaagaugacgaggaugaggaugaugaggaagaggaugacgaagaugaugaugaggaagaagaggagg


aagguaaccauauuaacuuuuaaaguaugcugaccuaaguaaggcuuacuggcuaugcuaaagugucugcuuacucaugaa


uggcauuuuaaaacaucuagaaccuguuaaagcagcaccuggaaaacggaagaaggagaugaccaagcagaaagaagccccu


gaagccaagaaacagaaaguagaagguaagccugcaaaacuggggaaacagaucagaguagcacuagcacaagugaugagug


acaaagggacuuaauacugaaccaugggguugaaaugaaauaugcugaugugcuuuauaguuuaugaugaaauuuguugu


gugcuuaagugggcugaaaguucauuuuuugugugugcaggcucagaaccaacuacaccuuucaaucuguucauuggaaa


ccuuaauccaaacaagucuguuaaugaauuaaaauuugccaucagugaacuuuuugcuaaaaaugaucuugcuguugugga


ugucagaacugguacaaauagguaaguuuuaauugaauguuacauguguaucagcuagaauuuuuaguuuccaguuguau


ucuucccugccuuuaaacauggggcuauaucuaacuauguuaguaaaagucaguugucuccucucguggccuuaaguacag


uuaaggagcugcaguaagaaagacuauaguauugaacuaaaugaucgagucauagggccugcaauuugaaguuccugugu


uugacuugauaaagauaaaauaaaauuuaaagaagaaaagauauuaaacacauaaaauuuugugcaguaucuacaacuaugg


aucugcauagucauaugcuuuuagcuaaaaguauucucuguacuuuuagcgggguccaugcuagcuacugcuguuaguua


caauauacugaaugaagaaaucgaggugaauuuguuguaaugucuugguacauggacuuguuuuguuuuuuguuuuuuu


uucuuuaagauuuguuuauguauaugagcacacuguagcuguccagaugguuuugagccuucaugugguuguugggaau


ugaauuuuuaggaucucagcucgcucugcucucaguccuugcuugcucuggcccaaagauuuauuuguuguuauacauaa


guacacuguagcugacuuaagaugcaucagaagagggcauuaggucucauuaugggugguggugagccaccaugugguug


cugggauuugaacucaggaccuucagaagagcagucaaugugcuuacccgcugagccaucucuccagccuuuggacuuggu


uuuauggaagauaagggugaucuaguuuuauuuuuguuagugcuguagaugcucugugugugugccacaugguauaagu


gcagaucaccuucucauaccuguaaucuuguuuuuuccaucuucaaggaaauuugguuauguggacuuugagucugcuga


agaccuagaaaaggccuuggagcucacugguuuaaaaguguuuggcaaugaaauuaaacuagaaaaaccaaaaggaagaga


uaguaagaaagguauguaagggggucugggugacuggauacuaacagacuuaggcagucuggugccucuuccuuaguuuc


auccucauugugaaccaaugagaugucauaggucaugugcuuguugacagguuugauuccugggauauauaaugucaggg


cugacaggaggaauagcuuagugaguaaagaugcuugcugcaaaauguuugaucucuagaagccacaugaagagagaagaa


ccuuuaaucccagcauuugggagacagaggcaggcagauuucagaguucgaggccagccuggucuacagagugaguuccag


gacauccagggcuacacagagaaacccugucucggaaaaaaaguuuuagcuuauccucugaccacauguguaucgugacau


gcuugaagcuuaccuaucucuuaaaugaauucuugaucccuauauuuugaguuucagaauuuggauuuuaaguguuuguu


ucuuaguugugcugaaaauugaacgugggcuuuucacaugcuaggcaaauuuguuggguuuuuuuguuuguuuuuuucu


caagacaggguuuuucuguguagcccuggcuguccuggagaccaagcuagccuugaacucagaaaucugccugccucccaa


gugcugggauuaaaggcgugagucaccacugcccugcuaggcaaucacucuuaaaacugcuacauauccucuguccccuuu


ugcucauuuuacaagguugcugugugcucaaucugcagucuauguuauaugcuuacuggaucuaggcuuuugauguagaa


ugaaccauaugagugaugagguaucuuagagauggaaacuaagucuaaauagacuuguuccauauacaacuuaauacauau


ggucuaaggaacaugauauacauguaaacaaguaggaaggagauaagucugguguccagggaagccaggagagccucaucu


gaaacuggacagggguuugugagucaucaggugacaauugaacauggguacucuucaugcaaaugguuaguaaccauuga


gccaccucuccaucccuuuauaccauuuuuuuuuuuagcauauauccuuguacuuuauaggaauuauuugcuuuauucuc


uugugacuuguaaauugauguacuuaauuaaaucuuuuuccaacauaguucgagcugcaagaacacuucuagccaaaaacc


ucucuuucaacaucacugaggaugaauuaaaggaaguguuugaagacgccauggagaucagauuagucagccaggauggga


aaaguaaaggguaguuuugugucuuugaguguuaaaguuuuauuaaguuuagugucuucuuccccucuccuuguccuug


acagucucuagucugcugcuucaaacuuaacuucauaaccagaaaauugaauaucugguccucuggccucuaccucccaag


uucugacauuaaaaaugcucaacugauggguuuugaaggugugaucaauuuuacaggcucaauccaaauuggcaucuuuu


gccacaaguacuauccuucccuauuuuaugagagaaaugugauucuaggcaguucagucuauuguguuggcucuuuuucc


uccucaccaguuuaaaggaugaagaugagcuaauacauaguaaaagaacaguaaaagcacaugugacuaaguccuucauguc


ugaugcuugaguaauauuuucucuaacguaguaacugaauugucuuguacucuuucaggauugcuuauauugaauuuaag


ucugaagcugaugcagagaaaaauuuggaagaaaagcagggggcagaaauugauggacgaucuguuucacucuacuauacu


ggagagaaaggucaaaggcaagagagaacuggaaagaccagcacuuggagugguaaguuaaaggguuuauuguguagugg


gaacaggaaucauuuguaucuuuguauuuuaaguaauugguuaccuacaauuaguucaccuuuguucauauagcugaugu


uuagucuucaugagugaaagcuauuugaaaucauuuccuuuggaguauaguaggcaaauaaagcuuuuuguuggguaugu


uuuguacuuuaaauggcuuaaacuauuuuagaaaauaguguaagacaacaaagaacaguuaucuaauuagaaugaaaauga


aaggagcaaagaaggcauuacuguauauaauggauauacacuggugguucuagaauuaugguauaugguacaugguugaa


gugccauuguuucaguuaacauuccaguaaccuuguggauuagguuggagacaugcuuuauaggugacccacuuacugag


uguuuaaauauacacagacauacucuaacauaccuugcuaauguguuaucuuuguauuugcaggugaaucaaagacuuugg


uuuuaaguaaccuuuccuacagugcaacaaaagaaacucuugaggaaguauuugagaaagcaacuuuuaucaaagugcccc


agaacccacauggcaaaccuaaaggguaaaauaauuuuuacguuagaugugggcuggacauacauacucuuacguauaaga


guaagacuguccuguuagcuuaaaaaaaaacuaaaguuuuagcuauacaaagggcaguaaauauugauaguaaauuacaug


cugaugccaaguguuucuaagcuuuauucugagaacugacuuucaaccuucagguaugcauuuauagaauuugcuucauu


ugaagaugcuaaagaagcuuuaaauuccuguaauaaaauggaaauugagggcagaacaaucaggcuggaguugcaaggauc


caauucgagaagucguaaguccuuugacaugauaugacuugguugggugauuuuuuuuuuuauuuuuaugugccuauau


gcucauuuggggcugucuuuauguuguugcugagaaaaugacaacuggauaugaugacugauuaccugagaaauaauuga


ugaaaucucaagaaaauuccucuagauagucaaguucugauccagcuaugucaacucaaagcagcaaccuugauugcccucu


gaguacgcuuuuuuuuugauccaguguagucuuuuuuuuuuuaaccuuaauuucuuguguuaauugcuuuuucugguaa


aagggggaaaaaaagacauaacaaaaucaguguaagggaaggcucagugguugagcacugagaggaccuggguucaaaucc


cagcacucacauggcaccuaucgagacaggauuucucuguguaguccugccugucguggaacucacucuguagaccaggcu


ggccucaaacucagaaaucugccugccucugccuccuaggugcugggauuaaaggugugcgccaccacugcccaacccugu


cuguaacucuuaagaucugacauagauugcagacaaaacacuaaugcacauaaaaaaauuuuuuuuuuuaaaaaaggaaucu


acuucagcugaauguggcaguauggcaguauucaccaaggguucauagugaaacaggaauuuuucucuuccagaaccaucc


aaaacucuguuugucaaaggucugucugaggauaccacugaagagaccuuaaaagaaucauuugagggcucuguucgugca


agaauagucacugaucgggaaacugguucuuccaaaggguaagaaggcguaguaguguugcugcuuuuuagugaauucug


cauggagaacuugggucugcaguaucuucucauugagcuccuuucuguccaucagugauagauuauggauucgcacgaga


agaagagagaauucacagaacuggcacuuaucuucuguuuuugcagaaguauauuuggcuguugugugagacauuaugag


auacuggcgauuuucucgaccugaagaguacuuuggucacucuacuugggugacuugguacuuauuguguuacuuuaaaa


uguguuuacuuaaugggugagguuuuuuuguuuuucuuuucuguuuuagguuugguuuuguagacuuuaauagugagg


aagaugccaaagcugccaaggaggccauggaagauggagaaauugacggaaacaaaguuaccuuggacugggccaaaccuaa


gggugaagguggcuuugguggucgagguggaggcagaggagguuucggaggcagagguggaggcagagguggaagaggu


ggauuuggaggaagaggccggggaggcuuuggagguaaggaagggaaaggaacuggaaacggauuccuaaaccugugucc


uaaccaaccaccuuaaaugggaaggucaguccuaauuguaucacccuuugauguuuuuccuuccuauagguagaggaggcu


uccgaggcggcagaggaggagggggagacuucaagccacaaggaaagaagacgaaguuugaauag












85
X57800
Sequence below.










uuagacgguugcgcgcgcagaggguugguaguugucgcuguaggccuucgcugccgcuucugcaucgugaaucgggggac


cuuggcagccagaccucguuccucuuagaguagcucucaucuagucgccacaacuccgccaccauguuugaggcacgccug


auccagggcuccauccugaagaaggugcuggaggcucucaaagaccucaucaaugaggccugcugggacgucagcucgggc


ggcgugaaccugcagagcauggacucgucucacgucuccuugguacagcuuacucugcgcuccgaaggcuucgacacauac


cgcugcgaccgcaaccuagccaugggcgugaaccucaccaggugagcggguggcgggagcggggccccacucuucccgcuu


ccgcucuuggcggggcugugacucugcacgcucauuggcuggcuuggccauccgcgcuuucugauuggucuauggugucg


ggggcagcccucaccaaagcgcgcgguuccgaaaagcccgcgcuggcaguggcgcccacucuguuuccgcgccaaagccaca


aagcgggaguccgcgggaaaaugagugcuccggagcugugcucauuaaaugccugcagcuuugaguggcuggucuuagcg


ccuaauaaacgagucuuagugcaaauguaaugucgacuuagagugacaauagaccuuuucuugacuuccagagucucacug


cgcaucauggauuugaggggaaaucugucaguuuuagcuuuuaacuuugcuacagcuaccuagguuagugccuccuguau


acguguucaaggacagugugugacuuauuuuaguacagauacauggauuagugccacuuguauacauuuugaaagauuua


cgaaaaggccagacgugauggggcacauucuccaguacacuagaaaccaaggacaccccgcucaaaaagaugcuuucucgaa


uguuggcuuuuagugcauuuuacuaagucgguuuuaagaaucacauauacccgguaauuugcuucaccccugagagaguu


ugggguacccuuagccccuuuaacaguucuccaaccgugagugugaaaugguacaacuuguaauugcuuuuuaaaauauag


auguggauuacauguugauaaagccugucuuuuuuuuuuugggggguagcauguccaaaauucuaaaaugugcugguaau


gaagacaucauuacauuaagggcugaagauaaugcagacaccuuagcacuaguauucgaagcaccaaguaaguuaaacaccu


uuaaaacucggaguuacguguuguuucuguuucucaaaaccaaaaaaaauauuaacaauauuguaaauuccaucauagaua


ggaccguguggugugcuugguaacauuuuccuucuuuugguagaucaagagaaaguuucagacuaugaaaugaaguuaau


ggacuuagauguggagcaacuuggaaucccagugaguuaccuuguuucugauuguguguuacccugcugugauaccagcu


gaugcguguucugaguggaguggugguauuggggaugaauggcacacugccauuucacuaaaccacagcagucuaaaguu


gauugaguuuuaaagaaaccagaagucuugcauucugaguucugguuaagaugcuaaaucuugagaacaugaagcugagcc


uucccccuuuucuagacugaccuuuaacuuguggguuuacaggaacaggaguacagcuguguaauaaagaugccgucggg


ugaauuugcacguauaugccgagaccuuagccacauuggagaugcuguugugauauccugugcaaagaauggggugaagu


uuucugcaaguggagagcuuggcaaugggaacauuaaguugucacaaacaaguaauguggauaaagaagaggaggcggug


aguaguaagggggcguccaguuaggugucugaagcagggauggagccucggcuuuuguuuuuauuuauucauucauuuu


gagauggagucuugaguagaccaagcuaucuuagagcucagagacgacuccauaagcuuuuacagguagcauuuggaaagc


uaaguguacagccuuuugcuuccuggaaauacucuuggcaaauaagugaggguuggcaagugagcaaaagaaaaugguug


gggguguauguagcuuuauguguugcagguucaagaguauuugcagucccaagggaaauaagaaagacuucacaaaaugu


ggaaagaguuguauuaaaugcucuugacaguuacauccauagagaaagcugggcaugaugucucaaacccacaacugaugu


acucaaagcuacagcaggaagauucucagcuuaaagucaaccuggcagaaaaucuagcucaaaaagaaugaggaagaaauug


ggaaggcaaaggaagauguucuccgaguccuccucauucaaguagaacauacuaggccucuuuaauuucuaaguaucccug


aaucgaggcuuuuucucaggaauccaauguauauuucauggcuacacuuuuuuuuuucuuuuuuaaguuuugcuagcuag


ccugagcaucagaauuacacacagaagucugaacuaaauaggauuuuuaggguuuaguauagugaaauucagagugcuucu


gcaaguauuuaagguaaauauaagguguuacuuggccucugcaugaauuuaaaguaaaugaaaguguaagaauucgaacau


agauaaacacacaacccaagaacuaguucuuaaccuuaaucugcugaauuauuucuacuuccauaucaacuucagcuccuca


guucucaaauacugacauguaauucaucaguauuugucugaugugcaagcauuuccacaacaaaagaaauuaaggaauuuu


ucaguauccacauguucaaggauugggaauugaauaaaauugauaaucauacaaugaagacugguuuacugucccuuagcu


ugcauucagcuguugguucuuguuuuuggaagugguuauguguuaucuuccucucuucaugcauucuuugcaagagaag


uauguacaaucugaauaggaacaacuuucuccuuuguuuugauugcuugggguguggcucuacaggaugggcaagcuaga


cuuuuuucuucuuuagucaagguuuucaucaacccuuccaaaaugauaacuauuuguuuugcuuugugguauaauaccgu


gaucuaauagugugaguuucugaugucuacagugagccuguuuucuccucuagguaaccauagagaugaaugagccuguu


caccuaacguuugcucugagguaccugaacuuuuucacaaaagccacuccacugucuccuacaguaacacucaguaugucu


gcagaugugccccuugguaagaugauaaguuugaacauuguuuuguaaugugguauuuauaguauucggugguuuaauu


uuuccugucuuucaguuguagaguauaaaauugcugacaugggacacuuaaaguauuauuuggcucccaagauugaagau


gaggaagcaucuuaggcauugcuagaaauugagaaaacuaaaccuuugaagauugcuccugagaugccagcguguccugag


gucuuuucugucaccaaguuuguaccugaguauucuuaaauauuaaaauaaaauauguagauaucuucuguaaauaaccua


cuuucuuuucucuccauucuccauaauuugcuuaaagaauaagcuccaaaguaaaaacuaguuuuguuaacaugaauguuu


cugcuuuacaaauacuggugauuuuccaucaaugaucuugacgcuaaaugcaguuuuaagaaauauuguucaauuuaaaua


aaguuaacaauuugaaaaguca












86
M35247
Sequence below.










ggugcaggauguaggccugcagaauugucagacccaguggcggcuuuugccacuggaagaauuuccaacauaaaacaga


ugaucaguuugggacaaucgauucugcgaccagagguagugucauuugguuacuuuuaaaauucagauugucuggug


uuuuccaaucacucgcgacuguaauuugaaguuggguucugagauaauacaaucgcugucgcucuaguuuauaaagcu


guccaagaucugcccagucccagauguccuggguccucagggccgcuguggucugccaacuucugcagcuggaugcca


gaccauccuggacucggaucccuuuggguauuucuacaccgcugugucccggccuggccuuggggagcccugguucau


aaucgucggcuauguggacgacaugcagguccugcgcuucagcagcaaggaggagacuccgaggauggcacccuggcu


ggagcaggaggaagcaggugacugggagcagcagacucguauagucacaauucaaggacagcugucugaaaggaaucug


augacccugguucauuuuuacaacaagagcauggacgacucucacacacuacaguggcugcaaggcugcgauguggagc


cagaucggcaccugugucucugguacaaccagcucgccuaugauagcgaggaucuccccacccugaacgaaaacccaagu


uccuguacagugggaaacagcacuguaccucacaucucucaggaccugaagagccacugcucagaucugcugcagaaau


accuggaaaaagggaaggagaggcugcugcguucagacccuccaaaggcacaugugacccgucaccccagaccugaagg


ugaugucacccugagguguugggcccugggcuucuacccugcugacaucacccugaccuggcaguugaauggggagga


gcugacccaggacauggagcuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugugguggu


gccucuugggaaagagcagaguuacacaugccauguguaccaugaggggcugccugagccccucauccugagauggga


gccugcaugguaccaaaagccuuggauuuggauuguugccaugguuuucauuuuguucaucauuugucucugugugg


uuugcauaugcaugaagaagaaugcaggugggagaggaaggcgugacacccaagaagcaggcagagacaguccccaaga


cucuagcaagacuguuguggaugaugaggagauggggguuugcuuuuggaagauuaaguccuguaaaacuugucuag


gccacuccccaggaacuucaguuggcgagucuuuacugucaccuugacuggauuuaggaucaucugggagaugccccu


uugaguggcugggcugugaggacagcaggccaguucuugccacccuggacagaaacacaucucaccuuucuggcucaag


gaucugaacaccugucucuugccuacucggcuucuagucaggcauuuugucaccuugucaagggucccagggacacaaa


gcucccuccucucacccacagcacucuggguccuacccucagugcuucagggacauuuaaucaggucaaauugggauca


auggcuuugaugcagaaaagaacuguggacuaauagagauaggguuuaauuaaaaaauauaucuuuuuaauuuu












87
AI553024
cuggcacggacauggcugucuucugucugcugugugggaaacgcuuucaggcacaaagcg




cacuccagcagcacauggagguccacgcaggcgugcgcagcuauauuugcagugagugca




accgcaccuuccccagccacacggcucucaagcgccaccuucgcucacauacagguuuuu




uucuccaugugucaccaagugaaguuugugccuucuauagcaaagagaauauuuuuuaca




uccuacuaacaguagauuuuuuuguagugaacauuuuuuguauuuuuauuuauaagucuc




auaagaaaaauagcgauguucaguuguauaccuugaaucugcaguuagaagagaauaaag




uuaacuc





88
X16995
Sequence below.










ggagccccagugcaggaggcugcgaaaguugggggagugugcuagaaggacugcggagcggagcgcacgcgggaccaggc


ugcgacugggucgcuggucccggccacagggagugggagccggcuggguagguaccccgcagggagcguguuucuguuuc


uagggacagugcaugaaagagaugggguguacgcgcgggcgaaaaggaaggguguuuucgggucggcuuacgaggagggg


uguguagggugcauuuuugguauuaaaggauagcucuuggaguagggugagccagggcuugaaguuuaggaagcgggcg


aagggucugcaaggugcuugguuuugguagguagugggcgcuuguuuaggagguuuccccgcuaggaucuccaguguga


ggcacucuguacucuggguuuggguguugauugccggguaggggguugucugagcauggacugggaaaagguacucaga


gcuucggcguugcuggggauccauccaaguacaaguaagauuggauuuccacgggucuccuucccggcucucagcccccuu


ucccaguguuuacuuaauacuucauaggcuguacuuagauuuucugauucccuuaccgaacuuucuuucugaaccgugcu


ggaagaccuggggguugcugaaggaaauggccagcuagguuggcuggguaaugguuguguuagacuaaguugucagagu


aucuagaaaccuaggagcuguagccuggugcagcuacugaaagccgcacguggagccuggguggaaguugcucacgauaga


gucucgauguaguacugacuaggggggagaccccuucugucaucagacagacuuguauaccccaguggucuuuugaaucu


guuagguagggugcagccugcgggcuuggucaccuaacagguguugccaggaccugccccaagccggauucucccacuccc


ucuuucaaccccgccucuuccuccuccuugagacacccccacccccucaggaggcuagaugcagaucuguaucuuguguug


cugacuaucggccugaagcuggguagauugguggggguugauccggauguaggauguccaaguggagaaacaggauuuga


auggagcuggaacaaacgcccaguccugacugcugccacccuucuuccuccacccccaacccaucccuucccaggcuucuug


caaacagaggcagaaguggccauauuucuuucuuucucccaggugcuguaugcccuagggacuugacacggggcaggcgg


ggugggaacugguuggggggggacgugcuguuuuaugggaagucguaugccuagccagcgguggagcuguccuggcuag


gcacccaggggugguguggggaaugggagaaauacugggacuagagggucucaagggccagcagguggugauagucuuuu


ucuccaccccacccucugcuccaccaccccucugccucagcaccccucugcccucagcaccccucugccucagcacccucugc


cuccagccacccucugccucagcacccucugccucagcacccucugccucagcacccucugccucagcacccucugccucag


uguuccugugugaccugucuuuucaacuagaaagucuagaacuguacagaccccagaguuggagguggaaagggacacuag


guccuggagccuccucugugggcuuuuuugaccagaugagaacguaagggccuccuccagcuaucccuggucauucaggu


gcuucagguuugugaccuuugcugagacccuggaugcugcagcaaacagacaucugcuuuagcagagggacagcuugucu


cugugcauccgcugguaggauccuccacucuguccaauuagcuugcgcugcugcuggguucugaguguucucuuacaaaa


ugacaagguuagggggcuggagagauggcucaggggcuaagagcacccauguggcaguuugcaacugucuguaacuccug


uuccaggggggaucugacacccucacacggacaaacaugcaggcaaaacaccuauuggcauggaaaaugaaaauaaaugacc


ggguuagcugagaaauuccuuuugagaguugucuuuucuccaguccaggacugcucucuggaucuuccugcucaguuccu


cgccucccuuccauauaugguauuuaagguuuuacuuuuuuuugcguuuucaauuguuuuuaauuguauuuauaugugu


cucugugugugcacaugagcauggguguccuacaaggcuagagacaucagauguccuggagcuagaguuacagaugguug


ugagccaccugauguaguugcugggaacuggauuuaguuccuguggaagagcagugcaugcucuuaaccacugagcaacu


ucuccacgcggcccccccccaguauacgguauuuaaaacucuauagcaaugcuacccaacccauuguggagcuggggaugg


ugagguggccuaguuccccccaacuccuggaaacaugucagaaaguacagagugggugccugugggaucagcaugcgggg


gguggugguggugagguguggggcugcuuucucccgaggcuaccgugauagacaguuguaccuugcuggcagccucuacc


ccauuuccaggaugucagucucugcagacguaugggggacgguggggaagggguauacagagccaugggugugccuggga


auguacucccaggaagugacugguugaaaagucagcagaucuccugggggauagaggggugggcugaagcucuguggguu


gccucucucagcccugaccugugaacagggaggcuggggguuggaggaacacagcuucccccuguuccuggggggacaug


cuggacagccuuuccuagcucccccggcccacugggguguggcuggucgucggacugagcucuuuuggaccuggucucug


ccugugagcuuugugacucguugagauagcauuugggcugagggauugggagucuucuguucuuugguccugacacccg


cuuccuugucuaggccugccaccuggcuccccccaccccccuccccggccuaccaaguuucuugcuucccuuacugaccccu


ccuccucccuccuuugugucuccucccucuccagagaugcccuguauucaagcucaauauggaacaccagcaacgagcccag


gaccgcgugaccaccugaccggugauccccuggcccuugaguucggcaagccuaccauggaccuggccagccccgagacagc


accugccgcaccugcuacacugcccagcuucagcaccuucauggacggguacaccggagaguuugacaccuuccucuaccag


cugccggggacgacccagccgugcuccucagcuuguuccucugccuccuccacgucuucuuccucauccucggccaccucc


cccgcuucggcguccuucaaguuugaggacuuccagguguacggcugcuacccgggcacccugagcggcccauuagaugag


acccuauccuccagcggcucugaguacuauggcagucccugcucagcccccucgccaucuacacccaacuuccagccguccc


agcuuucucccugggacggcucauuuggccacuucuccccgagccagacuuaugaaggccucugggcauggacagagcagu


ugccuaaggcuucuucagggccuccgccaccuccaaccuucuucuccuucaguccucccacuggccccagccccagccuggc


ccagaguucucugaaauuguucccaccaccagccacccaccagcuuggggagggggagagcuauuccaugccagcagcuuu


ccccggcuuggcacccaccucuccgaaccgugacacuuccggcauucuggacgcacccgugaccuccaccaagucccggagc


ggggcuucagguggcagcgagggccgcugugcagucuguggugacaaugcuucgugucagcacuaugggguccgcaccug


ugagggcugcaagggcuucuucaagguauuuuguugguucugggggacgaugauaucauguuggagguggggguggagu


gggucauccguugggaucuguagugaccucuccugagguuucuucccagcugguucuguccugcaggacgagggacaggu


gugugccaucuuagaggcugggacuuuuuauucagcagggcacacaucucucuagggcugcagaaagcuggggaaggggg


cagaagguguguguguguguggccugcaguggugcucagaaacagaaaaccuagugggcagccucugguucuccacagaa


cuuguguuucuggcacuggaugaaaggacacaggcagaggguuugguucuugcuggggguggacuugggaacaggcugu


guguuugucccagugcugggugccugcuuggcnnnncccaccuccanccccuuaguccucuccucugcgccaggaaaagg


gcagguggacacaugcagacaccuguuagaacaggugucuggacggccgugggaguuccuagacccuggucuuggguucu


gggaucuucccugugagguugaaaccuucuccaguaucucccagacuccucucugcgcucuggcccuccguuucucccucc


cccuacauccaaauguuaggaaaauagcuaugaacagagggcgcuuuugucugcgucggccacaggaucuggacggucccc


uccccugggcucuccaccccccccccaaaccccaugcucugacagccuguuccguguccccccuuccuccagcgcacaguac


agaaaagcgccaaguacaucugccuggcaaacaaggauugcccuguggacaagaggcggcggaaccgcugccaguucugcc


gcuuccagaagugccuggcugugggcauggugaaggaagguggguggcaagauggugcccucggcauaggcgaccugaug


gggugggacagccgggcucaccaggaucugcaccuaauucccacucccacuucuagauuccagccccuaaaugcaggugua


gcuuccaccugcuuucuggaaaggguggggugaggagggccuugugggguccccaucauggucugaguucucugucucu


gacuucucagaagugggguguauagugugcccugaagacccuccuucuccaggucuccuuucucaauacugcccgucucuc


ugcaguuguacggacagacagccuaaaagggcggcggggccggcuaccuucaaaacccaagcagccuccagaugccuccccu


accaaucuucucacuucccucauccgggcacacuuggacuccgggccuagcacugccaaauuggacuauuccaaggugagg


ucuugcccgcccaucugcccugcccugagaacauaugcaaugccuuugugccuguuaggaaaggcucucccuccagggcaa


caucaggaaacaagcauccucuauguacuggcuaguuggagaaaugcauugggauggguguggggucggggagccaguua


caaacagcugccguagcccuguuuuccugugggaauugacaagcacaugggcccagaauagggcucuuuugcacgccugga


ucuggugucccagugcaugagagcucuguaaugcagcuuguguaggcuuugcuguggacccaaugcaggacacagcugug


ugaugcaggccuugcuguggagccagugcgugacacagcuguguggugcaggcccucauguggaacuuaccugcguuccu


uucaguuccaggaacuggugcugccccgcuucgggaaggaagaugccggugacgugcaacaauuuuaugacuugcucucu


gguucccuggacguuauccgaaagugggcagaaaaaaucccuggcuucauugagcuuugcccaggagaccaagaccuguug


cuagagucugccuuccuggaacucuucauccuccgccuggcauaccgguaagcugcccaccauccuccuagcccuggcccca


gcccugcggccccggccugccuggacccugaguccugacuguucucugccuucugccagaucuaaacccggugaggggaag


cucaucuucugcucaggccugguacuacaccagcugcagugugcccguggcuuuggugauuggauugacaacauccuggc


cuucucacggucccugcacagcuuggguguugauguucccgccuuugccugccuguccgcucugguccucaucacuggug


aguggcagaaacuagacugggcccaaggguugcaggaccauuggguagguagcaucuaacacuuuggggaccccuagagug


ccugcaacauugggauguuaggaccugcaaagggacuuagcucuauucgccccuaaagcuuaaaucagccuccgaaugacc


ccggacuccucagguacgacuguaggcgcugggcaucuagcuuagggauucuguuuguuuaaaaaccuagcugucaaccuc


acaagacacaggaacgugcacacaugaauuuuucacauucugcgcuuggauagcuaucgccaugguccagaaacaggaccua


cuucagcucuguugggcucccuccuuauugucucuguaagagguaaccacucugccagccucaguggcauuccugucaug


gauuuuacugugcguaucacaggguauggacucuaguguuaaauguagagguuucugggucccuucucguuccgcuccca


uuuccacuuaaauuucuuaggggauccuccugaguagaucaagaccaggagcuggaucuugaaaggguagggagugauau


cuacacccagcucaguccuuagucuguccugcgagacuccaggauuuuagaacaguguggagccuggaccuccagaaaacc


uggauuaggcuuuugccuuggccagccauucagugguuucaaauauugaccagucuggacagugggcuccugugggacgu


gcuagagggcuggggaagcuugucagggagaaggcgucaacugagcggggcugacucuaccuucccugcugcagaucgac


acgggcuccaggacccucgucggguggaagagcugcagaaucgcauugcuagcugucugaaggagcacauggcuaccgugg


caggagacccacagccggccagcugccugucacgucugcugggcaaacugccugagcuucggacccugugcacucaaggcc


ugcagcgcaucuuuugccucaaguuggaggacuugguacccccuccaccuauuguggacaagaucuuuauggacacauugu


cuuucugaccccugcccugaacaugugugcgcacacgugcgugcucuucugucacccaugugccuuuaagccuauagccca


cggacccccagaccacccuacccccagccugguuuugagcuaagacugacguaccuccucacuccagaagauggacagagaa


cucaagaccugggggaggguguguauucacgggggugaccccacuauuugucuuaucccuccagcucaguccuggccuuc


guguguuuuuguaagauaaaccauuuuuaacacauaccacucuguuguaaauaagcugacgcuacuguaaauacagaaagg


aagagguugagauggggguugggaggaagggguggggcucccaccagcugggcgagccuccaacucgagaucucuuccgc


ucuccuuccauguguacauaacugucacucaagaaggugauugacagauucugauuuauauuuguguauuuuccuggauu


uauaggaugugacuuuucugauuaauauauuuaauauauugaauaaaaaauagacauguaguugaaa












89
AF038562
ggcacgaggcugugcccgccaugucugcuacccaucacaagaccucccugccucagggcg




uccgcgugggcacugucaugagaauucgaggcuuggucccugaccaggcuggcagguucc




auguaaaccugcuaugcggugaggagcaaggagcagaugccgccuugcacuuuaacccga




ggcuggacacuuccgagguugucuucaacaccaaacaacaaggcaaauggggccgugagg




agcgaggcaccggcauccccuuccagcgugggcagcccuuugaagugcuccucaucgcca




cagaggaaggcuucaaggcuguggucggggaugacgaauaucuccacuuccaccaccggc




ugccgcccgcccgcguucgcuugguggaagugggcggagacgugcagcugcauucauuga




auaucuucuaagcaaaggacccaagggccuuugcccgguuacggguuggggguuuuuuga




ucccacaagaaagguuuuggaucggccaauaacauuuuucuguuguucugaaaaauuaaa




aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa





90
Y11666
gccacauuguugcaccaacuccagugcuggagucucaggacaccaca




ggcuacccggaguuguucugcuuuggagauccgagggcaggagcaucacgccagugacuc




ugauaggugcgaucgccggauuggaacagaacugucauuuuuuuccgaaguugagccuua




gugacccagugagugaaguuagcgacgggacgcuaagcagcuagaccggucggcaggagu




gagacuuaggguaccuucuaguaguugugauuaaaaaaauugaaaaaaagaaaaaaaaaa




acccuguuucuggaaacuugaggcccucagcuggugagccaucgugguuaagcuucuuug




uguggcuccuggagucuucgaucccagccggacacccgggccugguuucaaagcggucgg




acagcgcugccugcuccaucgguagcgcucgagccucgguuucucuauuuggccccgacu




cgccgcaacaagaugaucgccucgcauaugaucgccugcuuauucacggagcucaaccaa




aaccaagugcaga





91
U40930
Sequence below.










cccagcuguuucguccguaccuagaccgcgguuauggcgucguucacggugaaggccuaucuucugggcaaggaggag


g


cgacccgcgagauccgccgcuucagcuucugcuucagcccggagccggaggcggaagcccaagccgcggccggcccggg


g


cccugcgagaggcugcugagccgaguggcugugcuguuccccacgcugaggccuggcggcuuccaggcgcacuaccgc


g


augaggauggggacuugguugccuuuuccagugaugaggagcugacaauggcuauguccuaugugaaagaugacaucu


uccgcaucuacauuaaagagaagaaggagugccggcgggaacaucgcccaccaugugcucaggaggcaccccgaaacau


ggugcaccccaaugugaucugugaugguugcaacgggccuguggugggaacucgcuauaagugcagugugugcccaga


cuacgaccugugcagcgugugcgaggggaagggccugcacagggaacacagcaagcucaucuuucccaaccccuuuggc


caccucucugauagcuucucucauagccgcuggcuucggaagcugaaacauggacacuuuggcuggccuggcugggag


augggcccaccggggaacuggagcccacguccuccucgugcaggggauggccgcccuugcccuacagcugagucagcuu


cugcuccaccagaagaucccaaugucaauuuccugaagaaugugggggagaguguggcagcugcccucagcccucuagg


cauugagguugacauugauguggaacauggagggaagagaagccgccugacacccacuaccccagaaaguuccagcaca


ggcacagaagacaagaguaacacucagccaagcagcugcucuucggaagucagcaaaccugacggggcuggggagggcc


cugcucagucucugacagagcaaaugaaaaagauagccuuggagucggugggacagccagaggaacagauggagucggg


aaacugcucaggaggagacgaugacuggacacauuugucuucaaaagaaguggacccaucuacaggugaacuccagucu


cuacagaugccagaaucggaagggccaagcucucuagaccccucacaggaaggacccacagggcugaaggaagcugcccu


auacccacaucucccaccagaggcugauccccggcugauugagucccucucccagaugcuguccauggguuucucggau


gaaggcggcuggcucaccaggcuccuacagaccaagaauuacgacaucggggcugcucuggacacgauccaguauucga


agcacccuccaccauugugauagugcuguggccaagccccacccccuuugucuuguaguugcaucacguagagcagcag


ggcuucuauagauaggcccagugucuuggcauucuuguagaaucuucaggugggaaugugugaugccuuuucaggcaa


uaggaaagugcaugaggagaguuuugaaugugcauaugcugacgccugagaacagacccagguacccguggcugagcu


gagcuuccucugcuuccccuaggccuggccucugcagggaacugcagcacacacugcacucccaccugcucuugccgcc


agcauugcaccagcaguccagaauuccugccugacaacccguguuuccuuuauuaaaagugauuaguacaacugcuagu


uauuuucaacaaauaaagccauuauguuaagaggggacuguccauagugagugaaagguggcaggcaggggccuacag


cuccuagggaauggagaauucaugugaagccgaaugaaggaucuuaucuuauacugucccccuuucuaauggccacucu


uuaguguuugugucuaauguuaaugcuuaaagcacaggacccccauguagcuuccucugacuugguuuguaaguaacc


uguaauaaaaugccauaugcacuuuaacca












92
D26090
Sequence below.










gagggaauugcgggaccccgucuggggaagcucccgccgccccggggugcucagcucucugucucccuugacccaggu


a


cagucaugucgggcuucgacgacccgggcauuuucuacagcgacagcuucgguggcgaccccggugcggaagagggcc


a


ggcccgcaagucgcaacugcagaggcgauucaaggaguuccugagacaguaccgagugggcaccgaucgcacgggcuuc


a


ccuucaaguacagagaugaacucaagcggcauuacaaccugggugaauacuggaucgagguggagauggaggaccuggc


c


aguuuugacgaggaacuggcugaccacuugcauaaacagccggccgagcacuuacagcugcuugaggaagcugccaagg


a


gguggcagaugaggugacccggccccggccagcuggagaugagcugcuccaagacauccaggucaugcucaagucagau


g


ccagcccgucgagcauucggauucugaagucagacaugaugucacaccuggugaagaucccuggcaucaucauuucagc


c


ucugcaguccgugccaaggcuacucguaucuccauucagugccgcagcugccacaacacccucaccaauaucgccaugcc


caggccuagagggcuaugccuucccaggaagugcaauauggaucaggcugggcgcccaaagugcccacuggauccauac


uucaucaugccugacaagugcaaguguguggacuuccagacucugaaacugcaggagcugccugaugcagucccucaug


gugagaugcccaggcacaugcagcuuuauugugacagguaccugugugacaagguuguuccugggaacagggucacca


ucaugggcauuuauuccaucaagaaguuuggcuugaaccccagcaagggccgggacaggguaggugugggcauccgga


gcucguacauccgagugcugggcauccagguggacacagauggcucuggccgaagcuuugcugggucugucagcccac


aggaagaggaggaauuucgucgccuggcugcccuccccaacauauaugagcucaucuccaagagcauuucccccuccau


cuuugggggcauggauaugaagaaggccauugccugccugcuuuuuggggguucccggaagaggcucccagauggacu


cacucgccgaggugauaucaacuugcugauguugggagacccugguacagccaagucucagcuucugaaguuugugga


gaagugcucucccauugggguguacacaucugggaaagguagcagugcugcaggcuugacugccucagugauacggga


ccccucaucucgaaacuucaucauggaagguggagccaugguucuggccgauggugggguugucuguauugaugaguu


ugacaagaugcgggaagaugaccguguugcaauccaugaggcuauggagcagcagaccaucuccauugcuaaagcuggg


aucacuaccaccuugaacucucgcugcucuguucuggcugcagccaacucaguguuuggccgaugggaugagacaaaag


gggaggacaauauugacuucaugccuaccaucuugucccgauuugauaugaucuucaucgucaaagaugagcacaauga


ggagagggacaugaugcuagccaaacaugugaugacucugcaugugagugcacugacacagacacaggcuguggaggg


ugagaucgaccuggccaagaugaagaaguucauugccuacugccgagcgagguguggaccucggcuaucagcagaggca


gcagagaagcugaagaaccgcuacaucaucaugcggaguggggcucgucagcaugagagggacagugaccggcguucca


gcauccccaucacugugcggcagcuggaggcuauugugcgcauugcugaggcccucaguaagaugaaacugcagcccuu


ugccacugaggcugauguagaggaggcauugagacuguuccagguguccacacuggaugcugcuuugucuggcaaucu


gucggggguggagggcuucacuacccaggaggaccaggagaugcugagccgcauugagaagcaacucaagcgccguuu


ugccauuggcucucaggugucugaacacagcauuguccaggacuucaccaaacagaaauauccagagcacgcuauccga


aaggugcugcagcucaugcuacgcaggggugagauccaacaccguaugcagcgcaaggugcucuaucgccucaagugag


cccauugcccaucaacccucaagccugaaaugcugccaccacccuaucucccagucagugcuccaaaccuccuuuugccc


ugccucuccaccucagacugcugucugcagcacaucugcagccccuggaaauguacuuuggucuguuggcucauacug


uguuugagugucugaggacucucugcucugggugucuauccccugucaugccuucucaacaagaugagucuggagcag


gaacaggcccuggaauguagaugggucuguauauuggcucccgggccacucacugccaagcuucuuuguauguacaga


gguaauaaagcaauugagucccuggcugcuaaggucaguggacccagu












93
AI787627
ggaugcagccggaagugcagcgugcgugcgguuuggugggucgcugugugcgcuccgcgu




gugcagccgcgugggccauggggcggcgggcgcggggccggcgguuccagcagccgccgc




agccugagggcgaggaagacgccagcgacggcggcagaaagcgaggccaggcgggcuggg




aagguggcuaucccgagaucguaaaggagaacaagcucuucgagcacuacuaucaggaac




ucaagaucgugccagagggagaaugggaccaauucauggagucacuccgagaaccucucc




cagccacacugagaaucacuggguacaaaagccaugccaaagagauucuccauugcuuga




agaacaaguacuuuaaggaguuggagganccugaaguagauggacagaaaguugaguucc




acaaccacuaagcugguacccugaagaacu





94
M33988
gagcucaaauucuggcuuucuauuggguacgauauauuaaccaaugggagaaacacaaac




agaauaccuccaguuaguauaaaugcuugcuguucaguugcagaauuuacuauauauucu




uuuccuuucucugcuuugccuuuacugauacuuaaacgcauacaugucuggacgcggaaa




gcaagggugcaaggcccgcgcuaaggccaagacccgcuccucccgggccggccugcaguu




ccccgugggccgcgugcaccggcugcuccgcaagggcaacuacucggagcgcgugggcgc




cggcgccccgguguaccuggcggcugugcuggaguaccugacggccgagauccuggagcu




ggcgggcaaugcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccugcagcu




ggccauccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcaggg




cggcguccugcccaacauccaggccgugcugcugcccaagaagaccgagagccaccacaa




ggccaaggggaaguaaucuggcgauugucuguacugcccaguugaaaguuaaccaaaaca




aaggcucuuuucagagccacccacaucuuuccauaaaaugagcugccaccucgugaaacg




uucuuccacuacaguuuuuauacuacauaugaaaaaguuacgaaguagcuuucaaucuua




guaaauugauuuuaauacuguuagucccugcgauaaaucuuacgaccuuccuuaguuuga




gucaaaaguguguaagagaugaaaccuuuagaacauacuauaaauuuuuaguagaaauuu




ggcacccagguuugucauucacgucacgauugucuagagcauaaugguaguaagggcuaa




gggccauuaaaucccacuuccauaguuuc





95
AI845182
uuuuuuuuuuuuuuuuuggaaaugaagguaauuuauugaaacugguuuugggacaggcga




guggacaacuguugaaaggagcuagcgcacagccgggugggagcgggugcuuagccacag




auccuaucugaggcccaacuuuuucuuuuccuucugcuucuuacggaccacauccagguu




ccgguccuuccacaugcuuuugcgaagcuugauggggcgugagcccacauacuucccauu




caucucucgcauggcgcgcacauagucacuggggucuuugaagcugacaaagccauagcc




cuugguuuugccugugcgcuuguca





96
AA619207
uucggauccuugccaauauauguaucccauuuggaauggugaucuuaaaaugugagugca




ugcauacuaucuuauuuaagauacuugcaccccacccacucccaucucccgaagcuggaa




cacugccaacuagguccuuaagaaucacgcaauuaacacaagguugggugcugcuaauuc




uucaugaaaauccaaacacguuaagggaccagggagaugccacugccccccugaauuuuc




aucaaaaauagacacguuuauguaaacagaacuauuuuccauauucauagugacuuuuua




aguauuugagccuaaagauuuugaucuccauuuuuauaacuauuuaaauuguucacaauu




auuacau





97
AW125783
cggccgccgccgcccccacacugccccgcguugacgagcgccgcgacggcaaggacagcg




ccucgcuuuucgugguggcucggauccuagcggaccucaaccagcaggcgccggcgcccg




cccccgcggaacgcagagaaggggccgcugcgcgcaaggcgaggacccccugccgccugc




cgccugcgcccccugcgccgccacccggcccagagcccgccuccccgggacaagcaggcg




cgccggccgcgccccccagccccgcguggagcgagccggaggcggcauuggagcaggagc




ccggccccgcggggagcggcgagccuggccucagacaaaggggucggggaggccggagcc




gcgcggaccucgaguccccgcagaggaagcacaagugccacuacgcgggcugcgagaa





98
J04103
Sequence below.










cgucaguccccgccaccuccccggccccgcgcgcccggaucggcccuacggccucgucucgcccggccuugcgcgccgggac


cgccgcgaucuccucuccccgccgcccuccggcuggcccugccugcugcggcgcgaugaaugacuuuggaaucaagaacau


ggaccaaguggccccugucgccaacaguuuucgugggacacucaagcgccagccagccuuugacaccuucgauggcucucu


guuugcugugcucccuucucucagugaagaucagacacuccaagaagugcccacgggccuggauucugucucccaugacuc


ggccagcugcgagcugccuuugcucacucccugcagcaaggcagugaugagccaagccuuaaaagccaccuucaguggcuu


ccaaaaggagcaacgacgucuuggcauccccaaaaaccccuggcuguggagcgagcagcaggugugccaguggcuucucug


ggccaccaacgaguucagccuggugaaugugaaccugcaccaguuuggcaugaacggccagaugcuguguaaccucggcaa


ggagcgcuuccuggagcuggcgccugacuuugugggugacauccucugggaacaucuagagcagaugaucaaagagaacca


agaaaagacagaagaccaauaugaggaaaacucucaccucaacgcgguuccucauuggaucaacagcaauacauuaggcuuc


agcauggaacaggcuccauauggaaugcaggcaccaaacuaccccaaagacaaucuccuggacagcaugugcccgccaucgg


ccacgccugcagcucugggcucugagcuccagauguugcccaagucucggcucaacaccgucaaugucaauuacuguucca


ucagccaggacuuccccagcagcaacgugaauuugcucaacaacaauucuggaaaacccaaggaccacgacucuccagagaa


cgguggggacagcuucgagagcuccgacucgcugcugagguccuggaacagccagucgucccuacuggauguacagcggg


uaccuuccuucgagagcuuugaggaggacuguagccagucucugugccucaguaagcugaccauguccuucaaggacuaca


uccaagagaggagcgacccagucgagcaaggcaaaccaguuauuccugcagcaguacuggcuggcuucacuggaagcggac


caauccaguuguggcaguuucuucuggagcuacucucugacaaguccugucaaucuuucaucagcuggacgggggaugga


ugggaguucaagcuugcugaccccgaugagguugcccgccggugggggaagaggaaaaauaaaccaaagaugaacuacgag


aagcugagccggggcuuacguuacuacuacgacaagaacaucauccacaagacuucgggcaagcgcuacguguaccguuuc


guaugugaccugcagaacuugcugggcuucacuccggaggaacugcaugccauccugggcguccagccugauacagaagac


ugagggccuca












99
D90146
Sequence below.










auggcucuaacaacgcugcucuuggugguggcggccgcccugacccugaucgagacccgcgcgggugagugcggggucgg


gagggaaacagccccugugccgcguccccgcuucgcccaccggaccuccgccccuucuccacccgagccccgagcccugcuc


cacucccggcccgcguacccgaccggggucccgggaggaggucggggucucaccgcgcgccgcccccaggcccacacucgcu


gcgguauuuccacaccgcugugucccggcccggacucggggagccccgguucaucaucgucggcuacguggacgacacgca


guucgugcgcuucgacagagacgcggaaaauccgaggauggagccgcgggcgcgguggauggagcaggaggggccggagu


auugggagcgggagacacagaucgccaagggccaugagcagaguuuccaagggagccugaggacugcacagagcuacuaca


accagagcaagggcggugagugaccccgggucggaggucacuaccucuccacgucccgaaacagaggccggugaggucccg


ggugcaaaguccgagguucaggagcagaacugacccaggacuggauucccuuucaguuuggaggaguccgcggugggggg


guggggggggggcggaggagggacugaccacugggucccgcaggcucucacacacuccaguggauguauggcugugacau


gggguccgacgggcgccuccuccgcggguaccugcaguucgccuaugaaggccgcgauuacaucgcccugaacgaagaccu


gaaaacguggacggcggcggacauggaggcacagaucacccgacgcaagugggagcaggcugguauugcagagagagaccg


ggccuaccuggaggucgcgugaggcuccgcagauaccugcagcucgggaaggagacgcugcugcgcacaggugcaggggcc


gcgggcagcuccucccucugcccucaggcuggggcucaguccuggggaagaagaaacccucagcugggguggugccccugg


cucagaggggagagagugacccugggucuccugaucccucaucacagugacugcacugacucucccagggcucagccuucu


cccuggacagugcccaggcugucucaggagggaaggagagaauuucccugagguaacaacagcugcucccuucaguucccc


uguagccucugucagccauggccucucccaggccaggguucucagccuacacccacugucuguagacacugacuccugucc


ugcugagugugucagcccuuacaccucaugaccugaagucuccuuuacccgaugggagacauggacaucuacacuaggcug


guucccccaguuucuagaacuuuccaaagaauacagucuaccagauccuucccugucugugggguuugcauccuuugacac


ccaauucuaucuauuccugcaauggugaauagucacaugagccauuauggguuacccuaaacaaauacuuuucuuguguuu


uuccccucucguuuucuuuuuaucuuuacuuuuuuuuuaaggguauuauguugcuuauaaucgguuuuucuucggcacu


ggaaugauauugcucucucuccccaccauacccccacccccgccuauaucauuuguaucaguagcccuggcugucguggaa


cucacucuguagaccaggcuggccuugaacucagaaaucagccugccucugucucugccucugccucccaagugcugggau


uaaaggcuugggccaccaccacugggcagaagaaagguuccugugagcuuaaaauguuuucuggcagaauuaaccauccag


aucacuccugauaucccugugccccaccaaguuacagugcucccccuggugaaucagaacuuggacucugagagacagggu


cuucugcaauccaggccugagugagagggaagaccacacacccugugagcccacuguguuccagugagugcugcacugggg


uccacagcacauuccagggauccugugugacacaucuguaccuugucccccagagucaggggcugggagucauuuucucug


gcugagugucagagguucaccacauuucugcuacacacucccugauggcuguuuacuuggacugacaguuaauguugguc


agcaagaugaccacagugguuuagucucaauggugucacucuuccaguagcauaugguccugauuucuaauuuagauacga


acucaaacacauaugaaauuucuuauuuuccauuccaucuuccauuauauagcuaccuaucucgugcuauugaacaucaca


uaaggaugaccauguugacccacuggcucauguggauucccucuuagcuucugaguccccucaggaaaaugugcaguccug


ugcugagggggccagcucugccugcaggucacuagugccaugacaguuaaaguguucauacagacacauaguucauuguaa


uuacugauuuagcguugucuuggcaguuuucaguuugcaugcauuuauuuauuuauuuauuuauuuauuuauuuauuua


augcauggaaguacacuguugcuguacugaugguuguuugccuuugugugguuguugggaauugaauuuuuuuuuuuag


gaccucucuuugcucuggucgacccugcucacuccggucaacuccuaugggucaacucugcucauucagucccugcuuguu


cuggcccaaagauuuauuuauuauuuauuauacauaaauacacuguagcugacuucagaugcaccagaagagggcgucaga


ucucauuacagaugguugugagccaccaugugguugcuggaguuugaacucaggaccuucaaaagagcagucagugcucu


uacccucugagccaucuccccaguccucaguuugucuucuuaauugugcgauuucuugaaucuuccaaacagaucccccaa


agacacaugugacccaucaccccauaucuuaugaugcugucacccugaggugcugggcccugggcuucuacccuguugaca


ucacccugacuuggcaguugaauggggaggagcugacccaggacacggagcuuguggagaccaggccugcaggggaugga


accuuccagaagugggcagcugugauggugccuuuuggggaggagcagaauuacacaugccaugugcaccaugaggggcu


gccugagccccucacccugagaugggguaaggagggugugggugcagagcuguggucagggaaagcuggagcauucugca


gacucugagcuggucagggcugagagcugggaucaugacccucaccuucauuuccuguaccuguccuucccagagccuccu


ccauacacugucuccaacauggcgaccauugcuauugugguugaccuuggagcuguggccaucauuggagcugugguggc


uuuugugaugaauaggaggugaaacacagguaggaaagggcagggucugaguucucucucagucuccuuuagaagugugc


ucuaaucauuaaugggaaacccaucuacaccccacauugcuaccuucuccaacuggguccucugucaguucugggaacuuc


caagaucuuccuugaacucucacagcuuuccuucucacagguggacaaggaggggacugugcuccagcuccagguuagugu


ggggacaggauuguccuguggacauugcagugaagcuggagauguuggggagcucugggaacccauaguaacucuuccag


agaaaucuuccagggccgcaguuguccaauaugaauacauauauguacauaugcauauacauuuuuuacccuuggcaggga


cagcuccuagagcucugauagaucucucccaggugguaaaggugacacucugggaccugauuggggaggggcaaugugga


uaugauuggguuucagggacuccacgaauccccucugagugagugguggguuguuggaauguugucuucacagugaugg


gucgugucccuc












100
AI563854
uuaaaucuggagggauuuuucacacagccuaucuuuuuaggugugccuuucccauauuuu




auuaaacucgaguuguuguuuuaaaaaaacagcagcauuaucaaagacacaucuguacaa




acauuuuacaaaagagaacucucuaggaucagcuacaucaaggacaagcagaaaaauaga




ugcaguccaacaaagacauugaaaaugacuu





101
AF017128
Sequence below.










ggucgcuuucugucuguagaggcggcuugccacccgagcagagggucgugaaguuccgaccggaccgguccacagaggu


ucaucuggagagguggguccccuccgaggugaaaggcgccgcugagaaacgcccccaccccccgugguucaagugguuca


gcccaagaacuuuucauucauaaaaaagaccagacuccgagaggcgcgagugagucagaaccgcagccgccaacgcggacc


cuaccgaacauccagcccagggcauguaccgagacuacggggaaccgggaccgagcuccggggcuggcagcccguacggu


cgccccgcgcagcccccgcaagcucaggcacagaccgcccagcagcaggugagacuggccgaaucgucgggggggggggg


accugaguuuggacagcaucagggaugcugggauuagucuaguuugcuccgggauuuggacuggggccccgagcagcau


cugacucugguggucgcgaccgaggauccugcacguucuguguggucggggaaccuauguacccgguggccaaggggac


gagcgcagcgggaagcgcgaauaucugcgaauuccccuucucgcucgcccguaucucccuagcugacugucuuucugccc


cuccgucuccguuacggucuuacauuuccuccuaucugccccuaauacgcugucccucuaaauaccugccccaucccugc


cuggacaggaucagagguguucuccaucuccaguuaauaacugggaccuggggucugggcacauagagacgggguccau


cagaacucagccgggacagagaauucuuagcagccuguccgaggcuguccguguguugcucugguuguccgugucccuu


uauccggucaaguccucaucucuuugugcgcaguauagagcccaugggccccaggcagugguuccgagggguuccugga


gaccacgaaguguugggaugugcgcggggucaccugcccggccacacucgcgcuccacauucucggcacccgacgucucu


cacugcuggauaggggcacuugagagguugcagguguccauuuccugucgaggggccgcgagcacgugucgccagggga


gggaaggagcugcguccguuucgccgagucacagcgggccgagucacugaggcugagucacccugggugccccucccuu


ccuggccccaaacggccccuaaggaccgacgaccugggagcgagagaugccccuggcagugcuucuagcccagaacgggg


gucacugagaugcugggucccccaguauugggcuggggacauagcuguccagacuugccuaagcaugugaggugcuucc


uggacuggagggcccccacauccuuagcucacagagcuugaacccaguuuucucucccagaacgcugagcccccaccccca


ccgacacucaaucccaacacaugccucagauuucugcaagaaaaggaaggaaaggaugccagaccccuuauaggaggcuuu


uacucucuucacuuuauuucauggacuuaaaaaaccccaucaauuuugaacuuucaaguuuuuaagucgacagcuaggca


ugcauuuaaucccagcauucaggaggcagaggcaggcagaucucugggaguuugaagccaauuuggucuacaaagugac


uuccaggucagcuagagcuacauaauagagauccugucucaaaacuuaaaaaauaaaaaacaaaaacaaaagccgauuaaa


acucugauuucugagcuaugagagcuggcuucucaacagcaauggaacguugaaugauguuaauaacagggaaacugag


acuaaauaacaugccccagucucaaagcccaucaauggccaagcuccaagcugaugcuggacucccaagcucuggugcuac


augucuauagucuuggugccugggagguagaggcagaggaaucgugaguuuaggucuagccugagcuaugugagaucc


ugcccaccccacccccggcccccaaacaacaaauucucauccugauucucagaauugccuugggagcuagaagcugaaagu


augcccaucugugaggacugggucucaaaucuuaguuucuacuuacuagcugugggucuaugggcaacugcucuccugu


cugaaaacaggauuauggcagcugugugagucacuauuuguuaaauaguuggaacaguguuacgcaguccauacuugau


uuaaaacaaaaaaccaaacuaucucugguggggaaacagacagacgaagagagacauuuugugaccugcccaaaaucacac


agcuccugaacaaguaaguuucugguugccaaauguugcuccuuguggucucccaaaacugguaucuacacugagguga


agggagacagaaguccagccucuguccccgggaagccccucaguccacacagaccuuaucauuucccuucuuaucucuca


gaaguuccaccuugugccaagcaucgacagcagcagccaggaacugcacuggauggugcagccucauuuccugggaccca


cuggcuauccccgaccucuggccuauccccaguacagucccccucagccccggccaggagucauacgagcccuagggccac


cuccgggggugcgucgcaggcccugcgagcagguaagaaacagcgauguuucacuuuccauagcccguagggguccuac


uagacagggacaggaucuugcuacgagggaauuucuuauucagcauugaaguuccugagaggccaagaaggagguaaaa


ggucaccuuugagucaaggaaggcuuccuggagaaggcuacacguuaaccuaaaccacggauaggauuugcguauggaa


gcugaaaagaaucuucugggaggaggguuggaggcacagaauugaggugaaggggacagaguguuaagugagcaugucu


ccacugucugacgugcacaggguggaaggaagccugaugcuggcuuuguaccucggggugacucuucuuuucaacaguc


acggaaucucagccuauuucuuuuaauuaucacaaaaagugagugggcagugguggcucacaccuuaaauuucagcacug


gggaggcagaggcagguggaucucuggguucaaggccagccugguuuacagagugaguuccaggacagccaaggcuaca


gagaaacccugucucaagaaagggaaaaaaaaagugaaugggaaauguauuucaauuuuuccaucuuccaucagaggaag


ugaagcauagagggguacucacuuguccagauucauacaaaugugaguaaugagacaggacugguccuggccugagguc


uacucaacucccaaagucagagcuuaaugagccacugucucaaugggagcucacagaagccugcagagggagugagcuga


gaacuuuugccucccugaaugccuuucuaaaauaaagaaggguguguuuugguugguuuguagagguggggucuugag


agccuccugccuucccaagugcuaggaguauagguguaugcuagauacccgacagggaugacggaucuuuuaggccaua


gcacuuucuuuccucucccugaaguacugagacugagucuagugcagggaggccuccauacuaaaaagcuggguguaccc


guaaucccagaacucggaaaaucaagacaggaggagccauucaagucacgcucagaaacauggagaguuuaaggucagcc


ugggauauauaaacccuaucuccgauaaccaaacaacaaucaaagcaaaccugacuuaaguguuaaguaggaaagaauaug


cuguaagucaucagccuggcugggggacugaccgccucugagggacugaagaaccugcuucaagcccggagcccugcacu


caaccccuaguggaugcacacacagauccuugccaugauggcucgaagagggauggcaagacccugggagauaugugaga


uuggccagagaagagccagcaacaggcuucccagcaagggaacagcuuaccucugugaucagcuggggcgugagcaagag


gcaagcccagggugaauccuuccuuuagcccuguccugaggagacaccuuuugaccacggguacuaguggguuggagcu


gugagcuguggguagguggcuuccccucggugugcucuggaacuugaacaaaucacucauccuuccugagcuuccucac


augugagugugcagagaucuggaugggugacucagcagcggcucuggcugcuccuuagaggauccggguuccaaucuca


gcacccacguggcaacucacuguccacaacgucccccaaagguucugaugcccucuucuggccuccaccagcacugaaugc


acaaggugcucauacaaacacacaggcaaaauacucagagguaaauuuguucuuuuuuuucuuuugagacaggguuucu


cuguauagcccuggcuguccuagaacucacucuacagaccaggcuggccucaaacucacagaggcaucugccugccuccc


aaguguugggaccaaagauguaugccaucacuauaagccuuuuuuuuuuuuguaaauuuuauuuaugaaugagugcuuc


cauguauaccuucaugccaggagagggcaucagauccuauuauaggugguugugagccaccguguguggcugggauuug


aacucaggaccucugaaagaggagcucuuaacugcuaaaacaucucucuagccccagucuacauauuuuaaaucuuuuuu


uaagauugauuuauuuauuauacauaaguacauuguagcugucuucagacacuccagaagagggcgucagaucuuguua


uggaugauugugagccaccaugugguugcugggauuugaacucaggaccuuuggaagaguagucaaugcucuuacccgc


ugagccaucucaccagccccuuuuuuaaucuuuaaaaaaaaaagggggggggccuggagagauggcucagccguuaagag


cacugaaugcuuuuccagagguccugaguucaauucccaacaaccacaugguagcucacaaccaucuguaaugggaucca


augcccucuucugguguaucugaagacagcaagggucuacucacauauguuaaauaaauaaauaaaaauuuaaaagccag


gugguguugguucagacagcagaucucuguuuaaggccagccuggucugaucuacaaaccaaguuccaggacagccagg


gcuacacagagaaacccucuaaaaaaccaaucuauguagggggugcuggugaaauggcuccguggguaaagguacuugcu


gcgaaauuaaugaccugaguucaauccuugaaauccacacaguagaaggagagaaccaaccuccaagggugcuaugacaca


cacacacacacacacacacacacacacacacacacacacacacacacgacuauauauaugaauauaugacucuagccaggca


uaguguggcacaugccuuuaaucacaguacuugggaggcagaggcaggugaaguuugaggccagccuacagagugaauu


ccaugacagcuagaacuaugaagaugaacccugucuuuaaaaacaacagcaacauaaagaaucuauguagggaagcuggaa


gggaugcugauacagucugcaauccuauuacucuagagguggaagccaaagaaucagggguuucaggccggucuugccu


auacacugagcuaaaggccagccugggacacaugagacuuugucucuuuuaaaaagacaaaacaaggggguugguuagau


ggcucaguggguaagagcacccaacugcucuucugcagguccgaaguucaaaucccagcaaccacaugguggcucacaac


caucuguaacgaaaucugagucccucuucuggagugucugaaaacaacuacaguguacuuacauauaauaaaaauaaaua


aaucuuaaaaaaaaaaaaaaaagacaaaacaagccagaugaggucugugaguuccaggccagccuggucuauaaaucaagu


ucaaggccaggcagggcuacucagagauucugucuaaaauacaaagaaacaaaacuacaaaaagcagaaaaaggaaucuac


gaaagggcuggugaagggguguaacucagugguagagcauuugccgagcuagcauguaccaagccauggguuugauccc


uagcacuaagcaaaagaaaaguccuacaaagggcuuuguuggcauaguagauugauucccaguagcuuuuggcacucaag


agcaccuucuacaauucacagcuccugggggaagaaaucccaucuuccacagaugaggaggcugagaguccugugaaaag


agauaaucaugucucauacacucaggagagaaggcuacuucugccugagaaaugaaaaggcuuccuggggucccaacauc


uuaguccaguccuaagaugcggaagggaggaagaucaaaguuuacagagagggaaagcauuucaggaaagaaaccagcag


uaaagcuaggugugugugagcuggaaaugucaccaaugagaugacaagcguccgguacagagaagcaacuguggagugu


ugggugguggcaccuagacuacagacugaaggaaagcuggaugaccagcucagggcagcugguggcucagagucagccu


cauugucucccuucuucuaucccaaccuagaucagcccagaggaggaagagcgccgcagggugagacgcgagcggaacaa


gcuagcagcugcuaagugcagaaaccgaagaaaggagcugacagacuuccugcaggcggugagcaucauccccaggcccg


gacccacagagccccaagaggggucucggcucccaagaacacaaaagacccaaaauuacuccucaggacucugucauccuc


ccugccuguggggaaguccuggaaaaaggauaagggaaaguggcuuaaauauuguuugucgggcuucgaggcagagucg


aagaugguaggcagcaauucuccuaagaugcccccgucugaugggagucauggccauuuucucccagaggcucacggga


gggaguugcaguccagacuuguuggggaugacaggcacagucccuacuccagccugaggcuuggggaucuuuagccuuc


auuuuccuaucuuucugcuaauccuguaaaggagaccgacaaauuggaggaugagaaaucggggcugcagcgagagauu


gaagagcugcagaagcagaaggaacgccuugagcuggugcuggaagcccaucgccccaucugcaaaaucccagaaggaga


caagaaggacccaggugguucuggcagcaccagcggugcuagcagcccaccagcccccggccgcccagugccuugcaucu


cccuuucuccaggacccguacuugaaccggaagcacugcauacccccacgcucaugaccacacccucucugacuccuuuua


cuccgagucugguuuucaccuauccuagcacaccagaaccuugcuccuccgcucaccgaaagaguagcagcagcaguggc


gaccccuccuccgacccccugggcucuccuacacuccuggcuuugugaggcacccagccacaucccuugcuggugcuacu


ccaagccauccccuuucucccauugauccagcaggccuggaccauacccuugccccaaaccagcagaucuuuuaucucuuc


cgacuagaacaaacacauuaugcuuugauguagagccagcuuggaggggauccccaaagcugcucacuguuuuucuagag


cuggccuaucauaauuugcacaaaauuagaggaaaauauguucccucugccagagaacgccuggcagcccagacuuugua


gauccccagggguccuuugacacccuuaccccuugcagaccacuuucccacaccacgucacuuucuucauguuauccagc


cuacucuacaccuagacagaaggugcccuuugacuagccuagaacacuaacucacacagcaucaacagccagcagcaccgg


acauccugcaggcuccuccugaauggcacaacgcaggaggcgccaggggcuucugugaggagcggagcugcacucccuag


cucugagaagcgcuuagcuucaggguauccgagccuccaccgcaagggcagcugcuauuuauuuuccuaaagagacuauuuuuaua


caaaccuuccaaaauggaauaaaaggcuug












102
X67644
Sequence below.










ccguggguuccuaauggugcuauugacgacgggcacaaagucucauaauuuuagaaacuucacuuauuuugugacccaccu


aguauggggcaaaggcaggagcuucggacuuccugucuucccucuaucccuuugaauagcgucucgggagugucccuaag


uaaccauugcaguuuuguguccgugugcucuguugaaaucucugugauguguguaugguuuucacgugaacggaggcag


gcagagcccggucuguggguucuaguguguucuuuaucuucuuggaaguuugugcaaugacuucccuccuguuuccugc


gcauaccuccaaguaaguacgugaauguguuuucuguggucccuugaucuugcuggacuucacuaaggaggguggcugga


ccaucugcuacgugucugagagccccucucuagcuaccucauguccggacgugagcuuacucccaauguuuuuacccacaa


gcauucacuacucccaggaaagaacgugcacuggggcaccuagagaauaaccaaucaacgcuccgccuacauuuugcuuccu


ccuuggaauuuccagccccuugcagccaacugcuccccagcugcgaagggcggaguuccccccggcccggccccuucuuug


gcucuauaaguagcucugcuuugcgggggauuugcacuccucuacacucucugcacaacgucuaaauuaugugccacucgc


gcaaccaucuccacaccaugacuggccugagggccccuucuccagcucccuccaccggcccggaacuccggcggggcucugg


ucccgaaauuuucaccuucgacccucucccggagcgggccgugguguccaccgcgcguuugaacacuucucgcgggcaccg


aaaacgcagccgaagggugcucuacccucgaguggugaguaucgcccgagugggcaucaggaggucgcgucgcccuggaac


uuguagguaacaacuaggagcagggaccuucgaucugacguuucccucuuuuaucugcucagguccggcgccagcuaccaa


ccgaggaacccaacauugccaagaggguccucuuucuccuguucgccaucaucuucugccagauuuugauggcugaagagg


gugugucgcagccccuggcuccggaggaugcuaccagcgccgugacaccugagcccauuucugcgcccauuacugcgcccc


cgguccucgagccuuugaaccugaccucggaguccucggacuaugcgcuggaucuuaaagcuuuucucuagcaacauccgg


cggccuucuaaacgcgaugggucacaguccgaagaaacaaaggcaccauggauggguaccuggugcgagagaacguauccc


aaacugggauuucuaaggcaacgcuaacucagaacacuaccgccaagagacaccgcggguccuggcuaggcccacuggggac


ggacagagacuuucuccgugucuaauuaauauuuauguauuuauguauauccuccuaggugaaggagggguguauguaau


auuuauucuaacuuaugcaggggugcgagauaugccucccugcuguaacacagauauuuauuacgauuuauagggucggu


aagacagaguugugggagggaggacccgggugguaggacucccagcuuggggauuagucugggggggguguaauaagau


uagggguaacacuccgucuuccagcacuucaacucuguagucuguuguaaggcuuuggaagacccuugggaauccggccu


uugaugucuucugguugcuucucaggggcagcugcaggagucuuggguccauggauugucagagggcggcugucugggg


ucgccuaguauguauguucugugaacacgaauaaacuugauuugccugucauuauuaucugcaguucucgaaguguauca


uucag












103
AF064088
See above (same Accession Number).





104
AI843085
uuuuuuuuuuuuuuuuuaaauugccgaauuaaguucuuuuaauagauugcauauauagau




guuuagccauacucuagaucaacucuuuaagaguagaauuuuauauccaauuuacaugcu




ucagauaucaccucuguuuguuacauaaggucuuguauccaaauguccacuuguacacug




agagcuuuaggaacaaaaaaggacacagagagaguugccauuuuuagcagcaaugaaaca




ucacuaaccccuuuuuacauaccgaauucaagucacuac





105
AW124932
cggccgccgguauuuuuuugcaaguauugagaguucuguauguuuugaaaagaguaauuu




uaacguuugggugccaagaaguggguuuucucagaguccauugccggcaaugggcaagcc




uggcgguacuccucgugccgaau





106
X58609
augg




cgcugggaacgcugcuccugcugcuggcggccgcccuggcccggacccagaaccgagccg




gugagugcagggucgggagggaaacagaacuuuccaaacagucugcggggaggggcgggu




gcggcaccggggaagccgcgugcccgcgucgcccaccagacccuccgucucuuuacccgc




gucccuagccccgcgcccugcuccccuccugucccgcgcauccgcccggggucccgggag




aaggucggggucucaccgcgcgccgcccccaggcucacacucgaugcgguauuucgagac




cgucgugucccggccgggccucggggagccccgguacgucucugucggcuacguggacga




cacggaguucgugcgcuucgacagcgacgcggagaaaccgagguaugagccgcgggcgcg




guggauggagcaggaggggccggaguauugggagcggaucacgcagaucgccaagggcca




ugagcagugguuccgagugagccugaggaaacugcuaggcuacuacaaccagagcgcggg




cggugagugaccccgggucggaggucaggccccuccacuucccgacacagggacgcugac




guccugguucccaagucugagguucgggaacagaacggacccgggaccgguuucccuuuc




aguuuggaggaguccgcgggugggcggggcugaccgcggggucccgcagguucucacaca




cuccaggagauguauggcugugaugugggaucggacgggcgccuccuccgcggguaccgg




caguccgccuaugauggcugcgauuacauugcccugaacgaagaccugaaaaccuggacu




gcgaaggauguggcagcgcugaucaccagacgcaagugggagcaggauggugcugcagag




uauuacaaggcuuacauggagggcgagugcgugcagucgcuccgcagauaccuggagcuc




gggaaggagacgcugcugcgcacag





107
M18837
Sequence below.










auggcgucaacaaugcugcuucugcugguggcagucgcccagacccugaucgagauccgcgcgggugaguaccggguccg


gagggaaauggccucugaggaaaggggagggggcggcacgggggaagccgcgucccggcgucgcccaccugacccuccgcc


ccuucuccacccuagccccgcgcccugcuccccucccggcccgcucacccgcgggggucccggaaggaguucggggucucac


cgcgcccugccuccaggcccacacuugcugaguuauuucuacaccuccgugucccggccgggccuuggggagccccgguuc


aucucugucgguuacguggacaacacggaguucgugcgcuucgacagcgacgcggagaauccgagauaugagccgcgggca


ccguggauggagcaggaggggccggaguauugggagcgggaaacacagaaagccaagggcaaugagcagauuuuccgagu


gaaccugaggacccugcucagcuacuacaaccagagcgcgggcggugagugaccccggaucggaggucacgaccccuccacg


ucccaaaacaggggcccgagacgucccgggccccaaguucgagguucugagcagaacggacgcgggacugguuucccuuuc


aguuuggaggagccgcgggugggcggggccggggcgugugggcggggcugaccgcggggucccgcaggcucucacacuau


ucaggugaucucuggcugugaagugggguccgacgggcgccuccuccgcggguaccagcaguucgccuacgacggccgcg


auuacaucgcccugaacgaagaccugaaaacguggacggcggcggacauggcggcacagaucacccgacgcaagugggagca


ggcuggugcuacagagaaaagcaaggccuaccuggagggcgcgugcgugcagucccuccgcagauaccuggagcucgggaa


ggagacgcugcugcgcacaggugcaggggccgcgggcagcuccucccucugcccucgggcuggggcucaguccuggggaa


gaagaaacccucagcuggggugaugccccugucucagagggagagagugacccuggucuccugaucccucaucacagugac


ugcacugacucucccagggcucagccuucucccuggacagugcccaggcugucucaggagggaaggagagaauuucccuga


gguaacaacagcugcucccuucaguuccccuguagccucugucagccauggccucucccaggccggguucucagcccacug


ucuguagacacugacuccuguccugcugagugugucagcccuuacaccucaggaccagaagucgccuuuaacugaucggag


acauggacuacccuacacuaggcugauugccucaguuuccugaauuuucaaaagaauacauucucccagaucccucccuguc


ugugggguuuccaccccuucgacaaccuaauucucucuauuccuauagugguggucacaucagcccuuaugggguacccug


gaggaauaucaauaguggaauuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuu


cuucuucuucuucuucuucuucuucuucuucuuccuucucucucucucucucucucucucucucucucucucucucucuc


ucucucucucucucucucucuucuucaguuuuugagauaggguuucucuguaugcccuggcuguccuggaacucacuugu


agaccaggauggccucgaccucagaaauccgccugccucugccucccagugcugggauuaaaggcguguggccaccuugcc


cagccuuucuuauuuucuuuacuuuuuuuuuuuuuuuuggaggggguaauuuuguuucuagucaucuuuugucuuuug


ucugcacuggagugauccuguuucucccugcccuuauauuaucauguguaucagucuccacaggugccagggaaguuaag


acaaguuaaaucaggguucucuuuaaaggagagauuccugugaacuuagacuguuuccugucagaacuaaacauccagaag


ccuccugcucuuccucugucccacaaguuacagugcuccccccccccccccagugaaucuggacuuggacucugagagacag


ggucuucugcaauccagggcuggagugagagggaagaccacacacccugugagcccacuguguugcagugagugcugcacu


gggguccacagcauacuccagggauccugugugacacaccuguaccuugucccccagagucaggggcuggaagucauuuuc


ucuggcugagugucagagguugacaccauuucugcuacacacucugugauggcugcucacuuggacuggcgguuaugcua


guuagcaagaugaacacagugguuuacgucucaguugucacacccuuccaguggcauauggcucuaauuucuacuuuuga


uacgaacucaaacacuuauuaaauuaguuaguuuccauuccaucuuccauucuaguccauucaugcuaaagaacaucacaua


aggacugccaggaugacccacuggcucauguggauucccucuuagcuucugagucccccagaaaaaugugcagcugaggaa


accagcucugccugcaggucaccagugccaugacaguugaagugucaaacagacacauuguucagugucaucagugauuua


acugugccuuguguagauuucagagggucuuguuaauugugguacuuuuuuuuguuuuuuguuuuuuuuuuuuuuugu


uuuguuuucaagacaggauuuuucuguauagcccuggcuguccuggaacucacauuguggaccaggcugaccacgaacuca


gaaaucugccugccucugccucccgagugcugggauuaaaggcgugugccaccaccaaccagcuaaucgugagauuucuuu


cuuuuuucuuuucuuuucuucuuuuuuuuuuuuuuuuuguuguuguuguuuuguuuuuugagacaggguucucugugu


aucccuggcuguccuugaacucacuuuguagaccaggcuggccuugaacuuagaaauuugccugccucugcuccggagugc


ugggauuaaaggcaugugccacuaccaaccagcuaauugugggauuucuuaaaucuuccacacagauccuccaaaggcaca


ugugacaugucaccacagaucugacggugaugucacccugaggugcugggcccugggcuucuacccugcuaacaucauccu


gaccuggcaguugaauggggaggagcugacccaggacauggagcuuguggagaccaggccuucaggggauggaaccuucc


agaagugggcaucugugguggugccucuugggaaggagcagaauuacacaugccaugugcaccaugaggggcugccugag


ccccucacccugagaugggguaaggagggugugggugcagagcuggggucagggaaagcuggagccuuuugcagacccug


agcugcucagggcugagagcuggggucaugaccucaccuucauuuccuguaccuguccuucccagagccuccuccauccac


ugucuccaacauggcgaacguagcuguucugguuguccuuggagcuuggccaucauugcagcugugguggcuuuuguga


ugaagagaaggagacacacagguaggaaagggcagagucugaguuuucucucagccuccuuuagagugugcucugcucauc


aauggggaacacaggcacaccccacauugcuacugucuguaacugugucugcucucaguucugggaacuuccuagugucaa


gcucuuccuugaacucucacagcuuuccuucucacagguggacaaggaggggacuaugcucuggcuccagguuagugugg


gggacagaguuguccugaggucauuggagugaagcuggaguuguugggugcucugggaacccauaauagcuucucuguu


guaauccucugguggccugugucagaucuugcuauagauauaucuuuguauauauuuuucccuaggcagggacagcuccc


agagcucugauauguuucucucaagauuguaaaggugacauucuauggccugauugcagaggggcacuguggacaugguu


guguuucagggacucccacaauccccugugagugguggguuguugggauauugucuucauuguggugguuccugacccu


cauucucuaucaugaagacagcugccuggaguggacuuagugacagccagugugaccuugggucuucauuuuucuuuaga


gaacagcgccugauguucccugugagccuaugggcucaaugugaagaauuguggagcccagccuucgccuacacaccagga


ccugucucuugcauugcccuguguucccuuccaccgccaaccuuccgggucugcag












108
AW124268
uuuuuuuuuuuuuuuuucagaauaauugcagacaaauuccauuuauuuuucuaaaaaccu




cauuaucuaaaauuuauacagccucacauuccuaaaccaccucuggcacuuuucuugaau




uaagucaaggcguacacagcuccgaaagaaaaauagagauccgguuccaggaagauggcc




augaggacucgcagauaugucuccucggaccuggaagcgugucagccaugggauccacua




auccaccauccgguacacagggucacccacucucaggcucccaagcuucuccaccgagaa




auacaucccaaaaaguggagaugacugguauauacucuucacagaaggaucacacaggcg




auagcucuucagggucuccaguggc





109
AF090738
Sequence below.










cucuagaugaauacacucucaugagggccaccuucucugguaguucaggucgccucugcccauccuucccugcguccucuc


ccaaaguggccuacaacccuuacccagaggacuauggagacauugagauugguucucacaagaguuccagcaguaaccugg


gggcagaugauggcuacaugcccaugaccccuggggcagcccuuaggagugguggucccaauagcugcaagagcgaugacu


acaugcccaugagccccacaagcgugucugcucccaagcagauccugcagccacgcuuggcagcggccuugcccccuuccgg


agcagccgugccagcacccccuucaggggugggcaggaccuucccaguaaacggagguggcuacaaagccagcuccccagcg


gagagcuccccagaagacaguggguacaugcgaaugugguguggcuccaagcugucuauggagaacccagacccuaagcua


cuccccaacggggacuaccucaacaugucccccagcgaggcaggcacugcagggaccccaccugacuucucagcagcuuugc


guggaggcagugaaggccucaaaggcaucccgggccacugcuacagcucuuugccccgcucuuauaaggcucccuguuccu


gcagcggagacaaugaccaguaugugcucaugagcuccccugugggccggaucuuggaagaggagagacuggagccccagg


ccaccccaggggcuggcaccuuuggggcagcuggugguagucauacccagccucaucacucagcagugccuuccuccauga


ggccgagugccaucgguggccgcccugagggcuuccugggccagcgaugucgggcagugcggccuacacgccuaucgcua


gagggacugcagacccuucccagcaugcaagaguacccucuacccacagagcccaagagcccuggcgaguacaucaacauug


acuuuggugaggcagguacccgucugucuccgccugcccccccacuacuggcauccgcggccucaucuucuucacugcucu


cagcuaguaguccugcuucaucccuggguucaggaaccccaggcaccagcagcgacagccggcagcgcucuccacucucuga


cuauaugaaccuggacuucaguucucccaagucccccaagccuagcacccgcaguggggacacaguaggcuccauggaugg


ccuucucucuccagaggcuucauccccauacccaccacugcccccacguccuuccacuuccccuuccuccuuacagcagccu


cugccaccugccccgggagaccuauaccgccugccuccagcaucagcugccacuucccagggucccacugcuggcuccucaa


uguccuccgagccuggggauaauggugacuauaccgagauggccuuugguguggcugcaaccccgccacaaccuaucgugg


caccuccaaagccagaaggugcccgaguggccagucccacaucgggcuugaagcggcuaagucucauggaucagguaucug


ggguggaggcuuuccuucaagucagccagcccccugacccccaccggggugcuaaggucauccgugcagacccacaggggg


gacgucgucgccacaguucagagaccuuuuccucuaccaccaccgucaccccaguguccccauccuuugcccacaauuccaa


gcgccacaauucggccucuguggaaaaugucucacucaggaaaagcagugaaggcagcaguacccugggaggaggugauga


gccgcccacauccccaggacaggcacagcccuugguggcugugcccccagugccacaggcuaggccguggaaccccggucag


cccggagcuuugauuggcuguccuggaggcagcaguucucccaugcgcagagagaccuccguggguuuccagaacggccuc


aacuauaucgccaucgaugugagaggcgagcagggguccuuggcgcagucucagccgcagccaggagacaagaacuccugg


agccggacccguagccuuggggggcuccucggcaccgucggaggcucuggcgccagcggaguguguggggguccaggcac


uggagcuuugcccucugccagcaccuaugcaagcaucgacuuccugucccaucacuugaaggaagccacagucgugaaagg


ugaggcccuuugaccuugaggaugggggagggagaguggaguauuggguggcu












110
AI834950
uuuuuuuuuuuuuuuuucagcugugaacuauuggauuugagacaggaacagaacaaaucg




acgggccagaggaggguggagagagcacgagugguuuaaauaggggaggaugggagcaug




gcggugggggugggggaagaguuauuuacaagaaggcucagggggccagaggcucaucuu




ggaauauuuuauaacaauauauauaagauucugguuugcuuuuccuuuucgucucguaaa




ggagagagaauugcauaguucgauucuguccaagggggcagcugcauauggucggccggg




cgggucacuggucgu





111
AI851365
uuuuuuuuuuuuuuuuuaagugucaccacuugugacagucagcauguuacuaucagcucc




agccgcagcguuuuuaaggcguuauagauuaggcaggcaauacaaggaacacgauuaaga




aacugacacguaccacacgagcaauuuccagaggcuccucuucugcggugcacacguaac




agugcucuuguugacauucagacaguucugagggccacucugagaggcgccuuccuguuc




ucaccugacaaggauauuguuugguuugguuugguuugguuuugccuuacuauggcuuuu




cuuucaacuacauuuugugucaugcuuguuagcuaacucaaauuuugucuuuguauauuu




acuacuguaaaauuagaauaauuuacuguucaucucauccucugucacugauggaaccua




gagacgccacaagagccacugccgugacauaccucacaagcuacaucccuguccucaaaa




u





112
AW047339
cggccgcggccaccggccugcgccaagcugcugcugcggcagccaguaccucggugaagc




ccauuuucagucgcgaccugaacgaggccaagcggagggugcgcgagcucuaccgcgcuu




gguaucgggagcgugccgaacaccgugcacuuaaugcagcuggauaucacggugaaacaa




ggacgggauaaaguccgagaaauguucaugaagaaugcccaugucacagaccccagagug




guugaucugcuggucauuaagggaaagauggagcuccaggaaaccaucaaaguauggaag




cagcggacacacguuaugcgguuuuuccaugaaacagaaacaccaaggccaaaggauuuc




uuauccaaguucuauaugg





113
U06834
Sequence below.










gcaccugagcgcgggugccuggcgcgcccgaugggaucguugagaggcccucgacggaaagucccaaacucggaucgcauu


cagccaaagugaggcggcgccauggagcuccgagcgcugcugugcugggcuucccucgccacugcuuuagaagagacccug


uugaacacaaaacuggaaacggcggaucugaaaugggugacuuacccucaggcagagggccagugggaggagcuaagcggc


cuggaugaggaacagcacagcguccgcaccuaugaggugugcgacaugaagcgucca


gggggccaggcucacuggcugcgcacuggcugggucccaaggcgaggugcuguccacguguaugccacgauacgcuucacc


augauggaaugccugucccugccgagggccagucgcuccugcaaggagacauucacugucuucuauuacgagagcgaacgu


gauacggccacggcccauacgcccgccuggauggagaaccccuacaucaagguggacacaguggccgcagaacaucugacuc


ggaagcgcccuggagcugaagccacagggaaaguuaauaucaagacgcugcgccug


gguccucucagcaaagcuggcuucuaccuggcuuuccaggaccaaggagccugcauggcucugcucucccugcaucucuuu


uacaagaagugcuccuggcugaucacgaacuugaccuacuuccccgagacggugccucgggagcucguggugccgguggca


gguagcugcguggccaacgcggucccuaccgccaaccccagccccagccucuacugccgggaagauggucaaugggcugag


cagcaggucacgggcugcagcugcgcgccaggguacgaggcugcggaaagcaacaaa


guaugcagagccuguggccagggaaccuucaagccccaaauaggagacgaguccugccugccgugcccagccaacagccacu


cgaauaacauugggucuccugucugccugugucgaauuggguauuaccgggcccgcucagacccccggaguucaccuugca


cuaccccacccucugcuccaagaagcgugguucaccauuugaaugguuccacccugcgccuggaguggagugcuccccuug


aguccggaaggccgagagaccucacuuaugcuguucgcugccgagagugccguccuggggguuccugcuugcccuguggg


ggcgacaugaccuucgaccccgguccucgagaccugguugagcgcuggguggcaauccgagggcugcguccugaugucacc


uauaccuuugagguugcugcuuugaauggugugucuaccuuagccacuggaccaccuccuuuugagccugucaaugucac


cacugaccgugaggugccuccugcagugucugacauccgagugacucggucgucacccagcagcuugauccugucaugggc


uauccccagagcacccaguggggccgugcuggacuacgaggucaaguaucaugagaagggcgcagagggccccagcagugu


ucguuuccugaagacaucagaaaaccgagcugagcuccgggggcugaagcggggagccagcuaucugguccagguacgcgc


acgguccgaggcuggcuacggucccuucggccaggagcaucacagucagacucaacuggaugagagcgagagcuggcggga


gcagcuggcccugauugcaggcacugcgguugugggugugguccugguccugguggucgucaucauugcaguucucugc


cucaggaagcagagcaaugggagggaaguugaguacucggauaagcaugggcaguaucucaucgggcacgguaccaagguc


uacauugauccuuuuacuuacgaagacccuaaugaggcagugagggaauuugccaaagagaucgaugucuccuaugucaag


auugaagagguaauuggugcaggugaguucggcgaggugugccggggucggcugaaggcaccagggaaaaaggagagcug


uguggccaucaagacucugaaggguggcuacaccgagcgccagagggcugaguuccugagcgaggccuccaucaugggcca


guucgagcaucccaacaucauccgccucgagggcguggucaccaacagugugccgguuaugauccucacggaauucaugga


gaacggagcccuggacuccuuccugcggcugaacgacgggcaguucacagucauccagcuggugggcaugcugaggggcau


cgccucgggcaugcgguaccuggcugaaaugagcuauguccaccgagaccuggcugcucggaacaucuuggucaacaguaa


ccuggucugcaagguguccgacuuuggccucuccagauucuuggaggagaacuccucugaucccaccuacacaaguucccu


gggaggcaagauucccauccgauggaccgccccugaagccauugccuucaggaaguucaccucugccagugaugccuggcg


cuaugggaucgucaugugggaggucaugucuuuuggggaacggccauacugggacaugagcaaccaggaugugaucaaug


ccauugaacaggacuaccggcugccuccuccuccagacugccccaccucccuccaccagcucaugcuggacuguuggcagaa


ggaccggaaugcccggccccgcuuuccccagguggucagcgcucuggacaagaugauccggaaucccgcuagccucaaaau


cguggccagggagaauggcggggccucacauccacucuuggaccaacggcagccucacuacucugcuuucgguucuguggu


cgaguggcuucgagccaucaagaugggaagauacgaggaaaguuuugcagcggcuggauucggcuccuuugagaugguca


gucagaucucugccgaggaccuucuccgaauuggagucacucuggcaggacaccagaagaaaaucuuggccagugugcagc


auaugaagugggaagcuaagccaggagccccuggugggacagggggaccagcccagcaguucugaccuccaaggacucacc


accguggcagauucuucuuuccgggaggcagaguuggguggggacucacaagaugagccccucccccucgucacagccuuc


ccauuggauugcacuuugaacagagggggucggagacacagauuuggggaaccgugccauaugggaucauacaugugccc


uccaggcggggaaccccaaacucagagugagucuuucccucaagacugggcaaagaaacaucccuacgucucuaaccuccca


ucuucccagaggcucucuccccaagcgccuuccaccucaacgggcaugucccugcagaccaaagagaaagggugaccagccu


gccaacuugggaguggaaaaugccgucccaggaggcaggaaggggcugucaggacccggugauguaaucauuggguuuug


auguccugacuugcugucaccaccaaaggcaaucauuuuucccuuguaaaugccccuccccucaucugccuucauauugaa


gguucugaaguuuuacuguuuuuuauuuuguuaauuuuuuccuccuuccccccucccuccccuucuuguccagauuuugu


guguuaaagggcaccugguuccacuaucuccuguugggaacaaggacccaucgauauguucuagaacagugccuuggaaau


gcca












114
AA980204
ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccgg




agccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagc




cggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgaga




ggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuaga




gacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcga




ggcugagcgggcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgag




cuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggag




ucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguugcg




ugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcug




gagaagagagcagcacaucu





115
AI843232
ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccgg




agccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagc




cggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgaga




ggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuaga




gacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcga




ggcugagcgggcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgag




cuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggag




ucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguugcg




ugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcug




gagaagagagcagcacaucu





116
U59807
Sequence below.










augauguguggcgcgccaucugccacaaugccagccacggccgagacgcaggaggucgccgaccaggugaggcugggccca


ggucaggccagucugagccaggccugcggagacccggcggccucagggaccggccugcccagacuggucagguccugcagc


ggguuuccggggcggccacaagugugacugggagcugggggcucuggaucugguuggaagauucagggccgggaacugg


ggcgagucuucugccgcuugcauacaagagggccacucaccuauuagggaacuagccccgggaucgguggagggauccggu


ggucccagagaauucaggaaggcaguguuagaaccuagacggcaccuuuuugacuuacacccaggccuaaacaagagaaagc


cagacugggcuacugugcuugucuccucaaaagaaagagcuaggacuguuuagcucaguggcaggaauucaacugauacca


ccaccaccaucaccaacaccgccccucagggaaaaaaaaaaggaucaaaaccagaaguuguagaacuugcuugugccuaguc


ugaaacgaggggguggaccuugggccugggcugcccuuccugugacuguuagcagagcagagauucaguacaagguaggg


ggagguucaggguauuagcaagagaagaaaaguuaaacaaauccucucuucagcucuccugccacgccccaagcccaggacc


cuguccacuaagccuagcugaucuugggagguguuugcucugaacugaaguggccaagaaggaagugagucagcuccaug


agacccuagaaaugaggaaauguuacagacacacuggccaggcaagggaaccuuggccacgugccacaucagcacucaggag


gcagagacaggcgagucucucugaauuugaagccagcccaguuugcuuaguuccaugccagccauagcuacauagugagac


ccugucccccccccccccaaaaaaaaggagcuguguuguucuuuaucaguggggccaacaguuuaccaugucccccggaau


gaggaguauugaaggcuggcagugugugugugugggggcaccugugcaugaaucuaaguccuuccuucucacccaccauc


caggugaagucccagcuugaaucgaaagaaaaucagaaguuugaugucuuuaaagccauauccuucaagagacagauagug


gcuggcaccaaccucuucaucaagguggguacugauaguagcuugccaugaacuggggacauagucucagaguagagcaga


guguccugcaacuuccugcagagaaccccuuaaggggacauguacauguucugagaggaugaauuugggguguuaggguu


cccggccuuaaaggaggagacaaggguuaucacuggcuaaguuaguggcugguggccuguucuggcucaguuucuaaggc


uggguuaagccuggaacuggaaccuuaccuuucacucacaugucugucugucugucuuccuccagguugauguuggugga


gauaaaugcgugcacuugaggguguuucaaccccucccccaugaaaacaagccuuugacccugucuuccuaucagaccaaca


aagaaaggcacgaugagcucuccuacuucuga












117
AI152659
gaaaauguuaagagccaucaaauuucuggauauuuugcuaggaaaaugaaauucuacacu




uauuuuuuguagacuuuuuuuaaaugcuguuuacaugaauuguauuuuggaaaaaauauu




auacugugcacccugugaugcaugaagugauuuuauguauggucugcuaugugggcagag




gucaccuuauuccuaugaucuggaauuguuuacuuucuacaaaguaagcuuuguggggau




uuugcuuucauuuucuuuguagcugauguuauuuuaccaggugugcagcaggaauuacac




cacuguguggaauuauaaauacaucccaugugca





118
AI850090
uuuuuuuuuuuuuuuuuccuggugaauauuuuuauuagaggugacaguuucccaggugac




aguuuuucccaaggaagcaaaucucugcgucuauaagggaagaccacagaaccuucacuu




uguaauuuaccuguguaauuuauccaagaacacagcacagcaauugcuuuaugugguacu




cugaccuuaaguaacaaguuguuaacagaaaacacaucaaacaaaaggauaauucucuaa




uuaucaagucagccaucagcuuuucuuaggagagagagagagagugugugugugugugug




ugugugugugugugugugucugucugucugucugucuggguaucccacuuagggccaugu




gcauguuagguaaaugcuccaccacugagcuguuucuuagccgcacuuuucucagauuuc




agguuuguuuguuuguuuguuuguuuuuuaacuaggcaugaaaauaaacuucacuucaaa




u





119
AF064635
See above sequence (A1850090).





120
AI843106
uuuuuuuuuuuuuuuuuguggaaauuacucuuuauugaaaaauaccaguaauacugacag




acuucaaaaucaauuuacgguuccagaauacaaaguacuuaauacauuuuuuuccaaacc




uguuuguaucucaaaguuagcauuuuuguaaaucaagauacaaauaugauaacuucacua




aaauauuuuccagcuuuauucuuuaaggagcuguauaaccuucaaagucagggucccgag




gucagcagggcauggggcagaaugcaccuggcacucccugugcagcagacugcaaccaca




uu





121
AF033186
auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggg




gaacucuuggcuccagcagcuccuuuugacaagaaaugugguggugagaacuggacgguu




gcuuuugcuccugaugguuccuacuuugcguggucacaaggauaucgcauagugaagcuu




gucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau




ucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccu




gagcacguuauagacuguggagacauagucuggagucuugcuuuugggucuucaguucca




gaaaaacagagucguugcguuaauauagaauggcaucgguuccgauuuggacaggaucag




cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga




aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca




gaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug




aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu




gcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuu




uggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua




gcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucgugug




uaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucg




cccacuccaauauuugcuggaggagcaaaugaccgaugggugagagcugugucuuucagu




caugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaauc




gaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucu




acugauggcaguguuuuagcugcugggacacaugauggaaguguguauuuuugggccacu




ccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugaugucc




acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc




gguuag





122
Z50159
auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggg




gaacucuuggcuccagcagcuccuuuugacaagaaaugugguggugagaacuggacgguu




gcuuuugcuccugaugguuccuacuuugcguggucacaaggauaucgcauagugaagcuu




gucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau




ucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccu




gagcacguuauagacuguggagacauagucuggagucuugcuuuugggucuucaguucca




gaaaaacagagucguugcguuaauauagaauggcaucgguuccgauuuggacaggaucag




cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga




aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca




gaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug




aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu




gcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuu




uggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua




gcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucgugug




uaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucg




cccacuccaauauuugcuggaggagcaaaugaccgaugggugagagcugugucuuucagu




caugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaauc




gaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucu




acugauggcaguguuuuagcugcugggacacaugauggaaguguguauuuuugggccacu




ccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugaugucc




acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc




gguuag





123
X78683
Sequence below.










gaauuccgugugcaaggcgaggucuguaagcuggagcggggcagaggcuggcgggcaccccuuccugaccgcuggugccg


ccgccgccgccuucgggaggaucagacauggcccagaacuugaaggacuuagcuggacgccugcccgccgggccucggggc


augggcacggcgcugaagcugcugcugggggccggggcgguggccuacggcguccgcgaauccguguucaccguggaagg


cggucauagagccaucuuuuuuaaucguauugguggcgugcagcaggacacgauccuggccgaauuucacuucaggauccc


cugguuccaguaccccaucaucuaugacauucgggccagaccucggaaaaucuccucccccacaggcuccaaagaccugcag


auggugaacaucucccugcgugugcugucccgacccaaugcccaggagcuccccagcauguaccagcgucuagggcuggac


uaugaggagcgagugcugccguccauuguuaaugaggugcucaagagugugguggccaaguucaaugccucgcagcugau


cacccagcgggcucaggugucccuguugauccgaagagagcugacagagcgcgccaaggacuucagccucauccuggauga


uguagcuaucacagagcugagcuucagccgagaguacacagcugcuguagaagccaagcaaguggcccagcaggaagccca


gcgggcccaguuuuugguggagaaagcgaagcaggaacagcgacagaagauugugcaggcugagggggaggcggaggcug


ccaagaugcuuggagaagcacugagcaagaauccuggcuauaucaagcuccgaaagauccgggccgcccagaacaucucuaa


aacgaucgccacaucacagaaccgaaucuaucucacagcugacaaccuugugcugaaucuacaggaugaaaguuuuacucgg


ggaagugacagccucauuaaggguaagaaaugaguguggacaucaagaaccccaccaccagagaaguuggcacacuugucca


gcuuggaggagccagcucggggucaagcacagcccacccugccccaggcaucaugugauggacuuuucuguaucugcccuc


uuggauuaaggaagacugagaccagcccuuucagaggcuuuccuccuuccuguguuggcugggaagcgggguggacaaug


ugauuucuccgugauuuccuacagccuugagccucucccagagugggggagauaaccaccaugccaggaauuc












124
X68193
acccaccggcuuucggaccauggccaaccucgagcguaccuucauugccaucaagccaga




uggcgugcagcgcggccuggugggcgagaucaucaaacgguucgagcagaagggguuccg




ccugguggccaugaaguuccuucgggccucugaagaacaccugaagcagcauuacaucga




ccugaaagaccguccuuucuucccggggcuggugaaguacaugaacucggggcccguggu




ggccauggucugggaggggcucaauguggugaaaacgggccgagugaugcugggggagac




caauccagcugauucaaaaccaggcaccauccguggggauuucugcauucaaguuggcag




gaacaucauucauggcagugauucaguggagagugcugagaaagagauccaucugugguu




uaagcccgaagaacugaucgacuacaagucuugugcccaugacuggguguacgaguagac




augaagaaaccagaauccuuuucagcacuacugauggguuucuggacagagcucuucauc




ccacugacaggauggaucaucuuuucuaaaacaauaaagacuuuggaacugaaaaaaaaa




aaaaaaaaaaaa





125
AA062013
uuuugcuuucaacaugacagaugccgcuguguccuucgccaaggacuucuuggccggugg




aguggccgcagcaucuccaagacagcggucacaccaucgagagggucaagcugcugcugc




aggugcacaugccagcaagcaaaucacggcagauaagcaauacaagggcaucauagacug




cgugguucguauccccaaggaacagggagugcucugguccuuugggcgugggaaccgggc




caaugucaucagauacuuccccaccaaggcucucaacuuggccuucaaaguuaauuccaa




gcagaucuuucugggugguguugacaagaggacccaguucuggcgcuacuuuugcaggga




accuggcaucaggugguugccgcuggggcuacauccuugggcuuuguguacccucuugau




uuuugccgguaccgucuagcagcugaugugggcaagcuggagcuaaagggaauucaaggg




ccuugggacugccugguaagacuucaaucugaugggauaagggcuguac





126
AI465965
auccgggacccccacggccccuuugcagcuugccacaagguucugagccccuuggaauac




uuccgccaauguguguaugacaugugugcccauaagggugacaaagccuaucucugccgu




agccuggcugcuuauacugcagccugucaggcagcuggggcagcagugaagcccuggagg




acagacagcgucugcccucuccaguguccugcccacagccacuacuccaucugcacccgc




uccugccagggcuuccugugcugcucucucuggccucacuggcugcaccac





127
U50413
Sequence below.










ggcacgagccgaguuggaggaagcagcggcagcggcagcggcagcgguagcggugaggacggcugugcagccaaggaaccg


ggacagcgaagcgacggcaggucgcagcuggaucgcaggagccugggagcugggagcuucagaggccgcugaagcccaggc


ugggcagaggaaggaagcgagccgacccggaggugaagcugagaguggagcguggcaguaaaaucagacgacagauggaca


gugugacaggaacgucagagaggauugggccucgcugcgagagucagccuggagucaagguguugacaaguugcugagaa


ggacacgugggaggacgguggcgcgcggagggagagcccugucuucagucaccccguugauggaggacagauggacagca


gccggacggccagucaccucucuuaaaccuuuggauagugguccuuugugcucugcuggacaccuguuggggauuuuagc


ccauucucugaacucacuuucucuuaaaacguaaacucggacggcagugugcgagccagcuccucuguggcagggcacuag


agcugcagacaugagugcagagggcuaccaguacagagcacuguacgacuacaagaaggagcgagaggaagacauugaccu


acaccugggggacauacugacugugaauaaaggcuccuuaguggcacuuggauucagugauggccaggaagcccggccuga


agauauuggcugguuaaauggcuacaaugaaaccacuggggagaggggagacuuuccaggaacuuacguugaauacauug


gaaggaaaagaauuucacccccuacucccaagccucggcccccucgaccgcuuccuguugcuccggguucuucaaaaacuga


agcugacacggagcagcaagcguugccccuuccugaccuggccgagcaguuugccccuccugauguugccccgccucuccu


uauaaagcuccuggaagccauugagaagaaaggacuggaauguucgacucuauacagaacacaaagcuccagcaacccugca


gaauuacgacagcuucuugauugugaugccgcgucaguggacuuggagaugaucgacguacacgucuuagcagaugcuuu


caaacgcuaucucgccgacuuaccaaauccugucauuccuguagcuguuuacaaugagaugaugucuuuagcccaagaacu


acagagcccugaagacugcauccagcuguugaagaagcucauuagauugccuaauauaccucaucaguguuggcuuacgcu


ucaguauuugcucaagcauuuuuucaagcucucucaagccuccagcaaaaaccuuuugaaugcaagaguccucucugagau


uuucagccccgugcuuuucagauuuccagccgccagcucugauaauacugaacaccucauaaaagcgauagagauuuuaau


cucaacggaauggaaugagagacagccagcaccagcacugccccccaaaccacccaagcccacuacuguagccaacaacagca


ugaacaacaauauguccuugcaggaugcugaaugguacuggggagacaucucaagggaagaagugaaugaaaaacuccgag


acacugcugaugggaccuuuuugguacgagacgcaucuacuaaaaugcacggcgauuacacucuuacaccuaggaaaggag


gaaauaacaaauuaaucaaaaucuuucaccgugauggaaaauauggcuucucugauccauuaaccuucaacucugugguug


aguuaauaaaccacuaccggaaugagucuuuagcucaguacaaccccaagcuggaugugaaguugcucuacccagugucca


aauaccagcaggaucaaguugucaaagaagauaauauugaagcuguagggaaaaaauuacaugaauauaauacucaauuuca


agaaaaaagucgggaauaugauagauuauaugaggaguacacccguacuucccaggaaauccaaaugaaaagaacggcuauc


gaagcauuuaaugaaaccauaaaaauauuugaagaacaaugccaaacccaggagcgguacagcaaagaauacauagagaagu


uuaaacgcgaaggcaacgagaaagaaauucaaaggauuaugcauaaccaugauaagcugaagucgcguaucagugagauca


uugacaguaggaggagguuggaagaagacuugaagaagcaggcagcugaguaccgagagaucgacaaacgcaugaacagua


uuaagccggaccucauccaguugagaaagacaagagaccaauacuugauguggcugacgcagaaaggugugcggcagaaga


agcugaacgaguggcuggggaaugaaaauaccgaagaucaauacucccugguagaagaugaugaggauuugccccaccaug


acgagaagacguggaaugucgggagcagcaaccgaaacaaagcggagaaccuauugcgagggaagcgagacggcacuuucc


uuguccgggagagcaguaagcagggcugcuaugccugcuccguagugguagacggcgaagucaagcauugcgucauuaac


aagacugccaccggcuauggcuuugccgagcccuacaaccuguacagcucccugaaggagcuggugcuacauuaucaacaca


ccucccucgugcagcacaaugacucccucaaugucacacuagcauacccaguauaugcacaacagaggcgaugaagcgcugc


ccucggauccaguuccucaccuucaagccacccaaggccucugagaagcaaagggcuccucuccagcccgaccugugaacug


agcugcagaaaugaagccggcugucugcacaugggacuagagcuuucuuggacaaaaagaagucggggaagacacgcagcc


ucggacuguuggaugaccagacguuucuaaccuuauccucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuuc


uuucuuucuuucuuucuuucuuucuaauuuaaagccacaacacacaaccaacacacagagagaaagaaaugcaaaaaucucu


ccgugcagggacaaagaggccuuuaaccauggugcuuguuaacgcuuucugaagcuuuaccagcuacaaguugggacuuu


ggagaccagaagguagacagggccgaagagccugcgccuggggccgcuugguccagccugguguagccugggugucgcug


gguguggugaacccagacacaucacacuguggauuauuuccuuuuuaaaagagcgaaugauauguaucagagagccgcguc


ugcucacgcaggacacuuugagagaacauugaugcagucuguucggaggaaaaaugaaacaccagaaaacguuuuuguuua


aacuuaucaagucagcaaccaacaacccaccaacagaaaaaaaaaaaaaa












128
AW120502
uuuuuuuuuuuuguuuuaauuuggcuccaaugaucgcauucucaaacuccuuugggaggg




cauuagaugacccaguauccgacgacuuagauucacacguguuuuucuccucugagcucu




uuucuccaggcucacngucuuuguuuuucaagcuuucuugggccuuugaacaauuuucuu




ccuuugaagauucuccugg





129
X62940
Sequence below.










agccgaguaggaccgagcugcugcagacgcgccgggucacucgagccagcaccaccguucucacgcccugagcugcagacag


cuaggcgguuuuaucuaguuugaaccaggcugcuggagcuugcucccucccgcccucucucuuuuuuuuccacggggcug


uuuuuuuaauuuggcugcaauugcaugaaaucccaaugguguagaccaguggcgauggaucuaggaguuuaccaacugag


acauuuuuccauuucuuucuugucgucuuugcugggaaccgaaaacgcuuccgugagacuugacaauagcucuggugcaa


gugugguagcuaucgacaacaaaauagagcaagcuauggaucuggugaaaagccauuugauguaugcggugagggaggaa


guggaaguucugaaggagcagaucaaagaacuaauagagaaaaacucccagcuggagcaggagaacaaucugcugaagacgc


uggccaguccggagcagcucgcccaguuucaggcccagcugcagacuggcuccccuccggccaccacgcagccacaggggac


cacacagcccccugcacagccagcaucccagggcucaggaucaaccgcauagccuccuaggccccaacagaacuggcugcug


cugcugcugucugaacugaacagaccgaagagaugugcuagagagaagccgccuccacagucacccauuucauugcugucu


acgaaagagacgugagacucacacgcuguucucgcuuucuccccaguauuaagcacucauaagcuuuuggcuugaagaaau


guacuaguugagugaauuaaagguuaaucagagagugagcagggaugugcccugugcaacguggcagaugucugaggaau


gguuuaauugaccccgaggagcucugugccuuuucaacccuccccagccgcccacccugcuucugagagcucgggcggcuc


gccuucguggggcucgccugcgugggguucgaaagugggcugcuccuggauucugcgcucucuucuccuucccuucaaag


aacucggagaggccagaaacaagacugcaauggggggcggggggagggaugaugcaguccuuauacaaaaccgacaacugu


caccaaagcuuauaaaacacgauaguacugucccucuuuucugaaccaucagaagacacaaaacuguuagugacacaacggu


gacagguagcugggaccuaggcuaucuuauuaugaagguuguuuugcuuguuguauauuuguguauguaguguaacgaa


uuuguaccauagaggacuguccguaacuacuguuuagcuucuacacauugaaauguagauguuucauuggcugucugaaa


agguguggcuuguccuuccuagagagaucuacuuaaaaacugcuuuguggcaaaaaccacaccugaagaaauuuuaagaau


uuggcccaguuagucacucuguguaaucccggaaucuagcugcugaagucuugcgaaguaaacuccccgugaccgauguca


guuaagcuggugauaccuggagaaguggucaguugcuaaggaaguggauuucccaguagggguuucugcaccucaccugu


auagucguucugcgcaugucccccacacaguccccaccuguauuuaccuguucuacuugucaccuuucaauaaagcauauc


aaauguugau












130
U60020
Sequence below.










auggcugcgcacgucuggcuggcggccgcccugcuccuucugguggacuggcugcugcugcggcccaugcucccgggaau


cuucucccuguugguucccgaggugccgcugcuccgggucuggguggugggccugagucgcugggccauccuaggacuag


ggguccgcgggguccucggggucaccgcaggagcccauggcuggcuggcugcuuugcagccgcugguggccgcacugagu


uuggcccugccuggacuugccuuguuccgagagcuggccgccuggggaacacuccgggagggugacagcgcuggauuacu


guacuggaacagucguccagaugccuucgcuaucaguuauguggcagcauugcccgcagccgcccuguggcacaaguuggg


gagccucugggcgcccagcggcaacagggacgcuggagacaugcugugucggaugcugggcuuccugggcccuaagaaga


gacgucucuaccugguucugguucucuugauucucucuuggcuuggggaaauggccauucccuucuucacgggccgcauc


acugacuggauucuucaggauaagacaguuccuagcuucacccgcaacauauggcucauguccauucucaccauagccagca


cagcgcuggaguuugcaagugauggaaucuacaacaucaccaugggacacaugcacggccgugugcacagagagguguuuc


gggccguccuucgccaggagacaggguuuuuccugaagaacccagcagguuccaucacaucucgggugacugaggacacag


ccaacgugugcgaguccauuagugacacgcugagccugcugcugugguaccuggggcgagcccugugucucuugguguuc


auguuuugggggucaccguaccucacucuggucacccugaucaaucugccccugcuuuuucuuuugccuaagaagcuggg


aaaagugcaccagucacuggcagugaaggugcaggagucucuagcaaaguccacgcagguggcccuugaggccuuaucggc


gaugccuaccgugcggagcuuugccaacgaggagggugaggcccagaaguucaggcagaaguuggaagaaaugaagacgcu


aaacaagaaggaggccuuggcuuacgucgcugaagucuggaccacgagugucucgggaaugcugcugaaggugggaauuc


uguaccugggcgggcagcuggugaucagagggacugucagcagcggcaaccuugucucauucguucucuaccagcuucag


uucacccaggcuguucagguccugcucucccucuaccccuccaugcagaaggcugugggcuccucagagaaaauauucgaa


uacuuggaccggacuccuugcucuccacucaguggcucguuggcacccucaaacaugaaaggccuuguggaguuccaagau


gucucuuuugccuacccaaaccagcccaaaguccaggugcuucaggggcugacguucacccugcauccuggaacggugaca


gcguuggugggacccaauggaucagggaagagcaccguggcugcccugcugcagaaccuguaccagcccaccgggggccag


cugcugcuggauggccagcgccugguccaguaugaucaccauuaccugcacacucagguggccgcagugggacaagagccg


cugcuauuuggaagaaguuuucgagaaaauauugcguauggccugaaccggacuccaaccauggaggaaaucacagcugug


gccguggagucuggagcccacgauuucaucucuggguucccucagggcuaugacacagagguaggugagacugggaacca


gcugucaggaggucagcgacaggcaguggccuuggcccgagccuugauccggaagccacuccugcuuaucuuggaugaug


ccaccagugcccuggaugcuggcaaccagcuacggguccagcggcuccuguaugagagccccaagcgggcuucucggacgg


uucuucuuaucacccagcagcucagccuggcagagcaggcccaccacauccucuuucucagagaaggcucugucggcgagc


agggcacccaccugcagcucaugaagagaggagggugcuaccgggccaugguagaggcucuugcggcuccugcagacuga












131
L32752
gaauuccggggccgcucucuccggcaggaucgccgcgauggccgcccagggagagccgca




gguccaguucaaggucguccuggugggcgacggcggcaccggaaagacgacauucaugaa




gcgccacuugaccggagaguuugagaaggaguauguagccacccugggcguggaggugca




cacauuagucuuccauaccaacagaggaccuaucaaguucaaugugugggacacagccgg




ucaggagaaguucggggggcugcgcgauggcuacuacauccaagcccagugugccauuau




aauguuugacguaacaucaagaguuacuuacaagaaugugccuagcuggcauaaagaucu




agugcgugugugugaaaacauccccauuguauuguguggcaacaaaguggauguuaaaga




caugaaagugaaggcaaaaccuauucucuuccaccgaaagaagaaucuucaguacuauga




cauuucugccagaaguaacuacaacuuugaaaagccuuucuucuggcuugccagaaagcu




cauuggagauccuaacuuggaguucguugccaugccugcucuugccccaccugagguagu




cauggacccagcuuuggcagcacaguacgagcaugauuuagagguugcucagacgacugc




ucucccagaugaggaagaugaccugugagaaagugaagcuggagcccugcgucagaaguc




uauuuuaggcaacuguccugugaugccagccagcggugcagugugugugccaccuuauuu




agcuaaaggagaucgugcaauucauugggaugcugaaggagaugaaugggcuucggagug




aauguggcaguuaaaauacaccuucauuuuuuuggacuugcguauuuagcccccuggaac




agaguuguucuggauuucaaagauaagacugcuaccguagcaucacaauagucaguggug




accggaauuc





132
AI840013
uuuuuuuuuuuuuuuuugauuuaugaaaaguuuuauuuaucaguacugugaagaauucuc




aucauaauugcuacguuaaucaaggaaaaggcacagagaagcaugugucguuugaguccu




cgauacuggaccucccagcccaugcucccuaugaggagucuagcugcugugguggucuuc




acagcuuugguuuucuggagacgaagcucaugauugcguucaugcacuccucugacagcc




accuugcuugcagaguagugcacucuucagcguugacugcguagagcuuuucuuucucau




uuuuucugauuaacucuuuggaaauucucauuggguuuggcgggagcuucgcauau





133
AB020424
ucgggaaucgauugagagaccgcgaaccuguaaacggaugauaccgagucgggcaggcgu




uaugccagcccaacucgggaccucgcaucauguccgcggcuaccuuagaguguuucggga




augauuugcgguggaugaacgaaaccccgguacguccugugccaaggagcauaugucagg




acggacgcucguuaaugccucagugguggggcaacguucgcucucuaucuauacgacucu




cgacaauggauaucucggcucucgcaucgaugaagaacguagcgaaaugcgauacuuggu




gugaauugcagaauccugugaaccaucgagucuuugaacgcaaguugcgcccgaggccuu




ucgguugagggcacgccugccugggcgucacgccuuguuuugcucugugcccgugcucuu




ucgggggcggucauggaugcggagauuggcccuccgugccucgugugcggcgggcuuaag




cgcggggugucggcgucgggaagggcacgacgagugguggacggagcaccagcaggaugu




uguggucccccgucaccuuaaggggcucaagagacccggacuaggcgagccgcgcuucgu




aagaggagggcgagcugucucgcaau





134
AI848453
uuuuuuuuuuuuuuuuugaaguugcugccccuuuauuggugacccgggcaaguuuaagga




gaacaacauuaaagcacacaaaguguauccaugucaccagcucaaccaggaggagugagg




gucacggcaggguucucccaugguguaagaaaucaacgcaauuucaucacaccccguuac




uuuccaaguuaacgaaccgauaagaaaagauucucccuuaaacugacaaguacaauguac




auguacaugauuuuggaauaauuuaauacuuuaaccucaagauacaacuauauucuaaga




ccauuauuuuaaaggaacggauccuuacaaaaccaaaauaacccauauagcacgagguug




guuuagccuuucuucuucuuucaacaaacgugcaccacauguuucaguagcaaggccgau




gccauggauaugagagcugugauuugcagggaccaaccacaucuagaaccggggaggcca




aucanacgguggguu





135
AU040563
cccuuggaggauaguuuuauugacaagucgaguuagguuuuagaguaaacuuuuaucacc




ccagucaggccccuucccaggggaggcucgcugguagcucagauggccuugguggugggc




agauuguuguaguugucuuccuggcccuccagcaggcuucgggagguggcuaucuccugc




uccagccuggacuugauguccaguagcugcuuauacuccggguucuggcgcucuaugugc




ggcacgcaggugcngcg





136
X89749
Sequence below.










ggacugacuccuugggcagauugccucuccuccuucucaugccagaggcugcugaugaggaaagguccaggggacugucca


ugcugucuucauccucagagucacugccugaugcugcaacaagacccuucuuguuuagcaauagugguuggaacacucucu


uguaaguuaccggagcacuaguauaggaggaggaucaucgacuacccucccgccacuccacggcugcuggcuccuagaaac


cccagcuucaccucucacugggacucgaguuccagaaugaaaagcaagaagggucuuguugcagcaucaggcagugacucu


gaggaugaagacagcauggacaguccccuggaccuuuccucaucagcagccucuggcaugagaaggaggagaggcaaucug


cccaaggagucaguccagauucugcgagacuggcuguaugaacacagauacaacgccuaucccucagagcaagagaaagcac


ugcugucccagcagacacaccuguccacacuacaggucuguaacugguucaucaacgcccgccgcaggcuccuuccugacau


gcugagaaaggauggcaaagauccaaaucaguucacgauuucccgccguggggccaagauuucagaagcuagcucuauuga


agcugcaauggguaucaaaaacuucaugccaacucuagaagagagcccauuucauuccugcguaguuggacccaacccaacc


cuagggagaccagugucucccaaaccucccuccccaggauccauuuuggcucgcccgucagugaucugccauaccacugug


acugcauugaaggaugggccuuucucucucugucagccgauuggugugggacagaguacagauguaccgcaaauagcaccc


agcaacuuuacagacaccucucucguguacccagaggacacuugcaaaucuggacccaguccaaacccucagaguggucuuu


ucaacacuccucccccuacuccaccagaccucaaccaggauuuuaguggauuccagcuucuaguggauguugcacucaaacg


agcggcagagauggagcuucaggccaaacucacagcuuaaccguuuuuucaaacaaaacaguucuccaaaauacgguccuga


uugccgggggugauggcaagagaugcauuauuuuauauauuuuuuc












137
AW125390
uuuuuuuuuuuuuuuuuggugguuaucaagugcacuuuauugaauccacuguggauagau




aaaugaguguuacaccugcguguagggaggggcaaggagggacgcagcugcggaggguga




agcacuucaggaccggaagucggaauccucuauuaagugugaagguuuugagcguuaaga




acaaugaugaugacacuaacaauggugauaacaaccaucaggaugcugaggaccaaggug




cugauguucaggcacuuagcaguggaggcguaggccugggcuccagucacaucacccacc




aucuuccgaucccuagacuucacggaguaggcauaggcuaugaagcccaggcagcagaag




uucaugaagaguguauugaacagggaccagaccacauggucaggcaccgacaccucucug




ggcauguugaucacaguaguucugacagaagccga





138
X05862
Sequence below.










aagcuucaggauacagugcacacucguaaauaaaaacuacaggcugcugcgaauuauauuucaacugaccggagaggcaaag


ccugacuguccauuaacccuuaacuuccaaacgcaaacugcuuacugcaucuuuuggcauuuuaccuuaugccuuguuagg


uccaaggcaagagaagcgucaucaauaaccacgcaugugcaacagcuuuuccagaggaaagguguggguggcucuuaaaag


agccuuugaguuaggagugugaguuaaacgagcucacuuggagcugguguacuuggugacugccuuggugcccuccgaca


ccgcgugcuuggccagcuccccgggcagcagcaggcgcacggccgucuggaucucccgggacgugauggucgagcgcuug


uuguaaugcgccaggcgggaagccucgcucgcgaugcgcucgaagaugucguucacgaacgaguucaugaugcccauggcc


uuggaggagaugccggugucggggugcacuugcuucagcaccuuguacacguacaccgaguagcucuccuugcggcugcg


cuugcgcuucuugccguccuucuucugggccuuggugacggccuucuuggagcccuucuucggggcgggagcggacuug


gcgggcucaggcauacugagaggaugaagugaacuaaguugaaaaaggauaacuaaaaguuaaugacuguucuggcugcaa


uuuuaaacaaacuuacggcuauggcaaccugaaucaccauacgucauguacuaacaguccaaucaaaacaagggauuuucaa


accagggcgccauugguaaccaauguguaaccaaugaaaucucuccguuuucgcguccagccuugacuauauauacuaugc


guauacguuuuugcuucuuacugcggugguuaucuacagcugaguuaugucuggacguggcaagcaaggacguggcaagc


aaggaggcaaggcccgcgccaaggccaagacgcgcuccucccgggccggccugcaguuccccgugggccgcgugcaccggc


ugcuccgcaagggcaacuacucggagcgcgugggcgccggcgccccgguguaccuggcggccgugcuggaguaccugacg


gccgagauccuggagcuggcgggcaacgcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccugcagcuggcca


uccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcagggcggcguccugcccaacauccaggccg


ugcugcugcccaagaagaccgagagccaccacaaggccaaggggaagugaaaccaaacauuacgaaucaccaaggcucuuuu


cagagccacucacuuucucaaagagaccuaacacuacugggauagugcauugugggaaauacguguauuaaccuuccuccu


auuuucccugcuugugguuaguucaaccccuaagccuuaggcuaagaguauauugguuuuuggaaggcaggcacccaacc


ucggaccuaguacauaaaacagacacaucuugaacuccaggccagccuacucugcaggacgaguuccaggacagaccggacu


gcacaaagaauugucuugaaauguuccuuuaucagcacauaugcugauaaacaacuaaucacuguacaaucaauccucacuu


gaauccuguuuauguggcaugauugacaaguccugccauuuggcaaagucaaaaucagcaaaggauguuaaagcauuuggu


gguaucacagcuaaaac












139
AW046181
uuuuuuuuuuuuuuuaugcaaauaguuuucaagauuuuauugcaaaccaaaauugguuua




ucgcacacaaaaaaaguugugugguaaggaggaggaauuguacaggauuauaacccaugu




uaauuacaguacauuaaaaugaugguuuacaaauaagccuguaaguuuaaauaucuagug




uuauaacccaauguacagacuuccuuuacacgauacauacaauaaucaggaaugcaaaag




aauaugaacaaagggaaaaaaaacauaaauaaugcccguuuuauaggugacauuuuaaac




aauugaaaacaccaaccggcuuugacugacaacuggggcauugguccauaaaaacccuuu




cuaaaaauagaaauau





140
U10118
Sequence below.










gaggcugcucaagagcugcgguugggucaccgcuucauguuucucugccgauucuggggaaagauggcaacgaaugaugc


uguucugaagaggcuggagcagaagggugcagaggcggaucagaucaucgaauaucucaagcagcagguugcucuucuua


aggagaaagcaauuuugcaggcaacaaugagagaagaaaagaaacuucgaguugaaaaugcuaaacugaaaaaagaaauaga


agagcuaaagcaagagcugauucuggcagaaauucauaacggaguggagcaagugcguguucgauugaguacuccacugca


gacgaacuguacugcuucugaaaguguggugcagucuccaucaguagcaaccaccgccucuccugcuacaaaagagcagau


caaagcgggagaagaaaagaaggugaaagagaagacugaaaagaaaggagagaaaaaggagaagcagcagucggcagcagca


aguacugacuccaagccuaucgacgcaucgcgucuggaucuucgaauugguuguauuguuacugccaagaagcacccugau


gcagauucacuguauguggaggaaguagaugugggagaagcagccccgcgcacggucgucagcgggcuggugaaucaugu


uccucuagaacagaugcaaaaucguauggugguuuuacucuguaaucugaagccugcaaagaugcggggaguucugucuc


aagccauggugaugugugccaguucaccagagaaaguggagauucuggccccucccaacggguccguuccuggggacagaa


uuacuuuugaugcuuuuccuggagagccugacaaggagcuaaacccuaagaagaagaucugggagcagauccagccugacc


ugcacaccaaugcugaguguguggccacauacaaaggagcucccuuugaggugaaggggaagggaguuugcagagcccaaa


ccauggccaauaguggaauuaaauaagugcucuguaacugaaagacauuggcgaaaacuuaauaacaauaaagagaagugu


guuuaucacuuacauau












141
AW212775
ggccuuguuuuugguuugcaauaaagaguauuucuuuaaaaggcacauuuuguuaaauag




gcaguuccccuccugccucuuccuuuguagcaguguacugcauccuagaaacauuuagca




aagcagcccuuagccuccccgacccccuuucccucccucccagca





142
AI846302
uuuuuuuuuuuuuuuuuaaacaaugacgccguuuauuuaaaauguuuacucccagaaaua




uagauauaaaaaaaaaaauaagacaauuaacagcacuaaaccaggcaccuucaaccgaau




cccaccauccucguuaacucccuuccuguuacccuuuguagaugaccagaagauuucagg




agccccuggacagccagagugguuccugcccagggcuucccgccuuccuccuguccuaga




gcuucccgugggaaagcuugggugagaauuuuagccuaaagggagggggcuguggccggg




cacuuugcgcucauccacugcagg





143
M22998
Sequence below.










acaggguacaguugugcgucagggcguggaggucuggcgggagacgcauaguuacagcgcguccguucuccgucucgcag


ccggcacagcuagagcuucgagcgcagcgcggccauggaucccagcagcaagaaggugacgggccgccucauguuggcugu


gggaggagcagugcucggaucacugcaguucggcuauaacacuggugucaucaacgccccccagaagguuauugaggaguu


cuacaaucaaacauggaaccaccgcuacggagagcccaucccauccaccacacucaccacgcuuuggucucucuccguggcc


aucuucucugucgggggcaugauugguuccuucucugucggccucuuuguuaaucgcuuuggcaggcggaacuccaugcu


gaugaugaaccuguuggccuuuguggcugcugugcuuaugggcuucuccaaacugggcaaguccuuugagaugcugaucc


ugggccgcuucaucaucgguguguacugcggccugacuacuggcuuugugcccauguaugugggagaggugucaccuaca


gcucuacguggagcccuaggcacacugcaccagcugggaaucgucguuggcauccuuauugcccagguguuuggcuuaga


cuccaucaugggcaaugcagacuuguggccucugcugcucagugucaucuucaucccagcccugcuacaguguauccuguu


gcccuucugccccgagagcccccgcuuccugcucaucaaucguaacgaggagaaccgggccaagagugugcugaagaagcu


ucgagggacagccgaugugacccgagaccugcaggagaugaaagaagagggucggcagaugaugcgggagaagaaggucac


caucuuggagcuguuccgcucacccgccuaccgccagcccauccucaucgcuguggugcugcagcugucccagcagcuguc


ggguaucaaugcuguguucuacuacucaacgagcaucuucgagaaggcaggugugcagcagccuguguacgccaccaucgg


cuccgguaucgucaacacggccuucacuguggugucgcuguuuguuguagagcgagcuggacgacggacccugcaccuca


uuggccuggcuggcauggcaggcugugcugugcucaugaccaucgcccuggccuugcuggaacggcugccuuggaugucc


uaucugagcaucguggccaucuuuggcuuuguggccuucuuugaaguaggcccugguccuauuccaugguucauuguggc


cgagcuguucagccaggggccccguccugcugcuauugcuguggcuggcuucuccaacuggaccucaaacuucauugugg


gcaugugcuuccaguauguggagcaacugugcggccccuacgucuucaucaucuucacggugcuccucgugcucuucuuc


aucuucaccuacuucaaagucccugagaccaaaggccgaaccuucgaugagaucgcuuccggcuuccggcaggggggugcc


agccaaagugacaagacacccgaggagcucuuccacccucugggggcggacucccaagugugaggagccccacacccagccc


ggccugcucccugcagcccaaggaucucucuggagcacaggcagcuagaugagaccucuuccgaaccgacagaucucgggc


aagccgggccugggcgccuuuccucagccagcagugaaguccaggaggauauucaggacuuugauggcuccagaauuuuua


augaaagcaagacugcugcucagaucuauucagauaagcagcagguuuuauaauuuuuuuauuacugauuuuguuauuuu


uuuuuuuuaucagccacucuccuaucuccacacuguagucuucaccuugauuggcccagugccugaggguggggaccacgc


ccuguccagacacuugccuucuuugccaagcuaaucuguagggcuggaccuauggccaaggacacacuaauaccgaacucu


gagcuaggaggcuuuacgcuggaggcgguagcugccacccacuuccgcaggccuggaccucggcaccauagggguccggac


uccauuuuaggauucgcccauuccugucucuuccuacccaaccacucaauuaaucuuuccuugccugagaccaguuggaag


cacuggagugcagggaggagagggaagggccaggcugggcugccagguucuagucuccugugcacugagggccacacaaac


accaugagaaggaccucggaggcugagaacuuaacugcugaagacacggacacuccugcccugcuguguauagauggaaga


uauuuauauauuuuuugguugucaauauuaaauacagacacuaaguuauaguauaucuggacaaacccacuuguaaauaca


ccaacaaacuccuguaacuuuaccuaagcagauauaaau


ggcugguuuuuag












144
X64837
Sequence below.










gcuuucuaaacuagcaagcaucguguggguccuucaggagugggagugcagacagaccugacagcguccgcuaagcgacac


ugacuguacuuccacuccugaaggacccacacgaugcuuucuaaacuagcaagucugcagaccauugcugcucugcgccga


ggaguccacaccucagucgccucugccacgucuguugccacaaagaagacagagcaaggcccaccauccuccgaguacauuu


uugaacgggaaucuaaauauggugcacacaauuaccauccuuugccuguagcccuggagagaggaaaaggcauuuauaugu


gggauguggaaggcaggcaguacuucgauuuccugagugcuuauggugcugucagccaaggacacugccacccaaagauca


uagaugccaugaagagucagguggacaagcugacauuaacaucucgggcuuucuauaacaauguccuuggugaauacgagg


aguacaucaccaagcuuuucaacuacaacaaaguucucccuaugaauacaggaguggaggcuggagagacugcauguaagc


ucgcucgucguuggggcuacaccgugaaaggcauccagaaauacaaagcaaagauuguuuuugcugaugggaacuuuugg


ggucgaacacuaucugcaaucuccaguuccacagauccgaccaguuaugauggcuuuggacccuucaugccaggcuuugaa


accaucccauauaacgaucugcccgcacuggagcgugcucuucaggauccaaauguugcugccuucaugguggagcccauc


cagggugaagcaggcguuaucguuccggauccaggauaccugacaggaguucgggaacucugcaccaggcaccagguccug


uuuauugcugaugaaauacagacaggauuggccagaacugguagauggcuggcuguggaucaugagaaugucagaccuga


uaugguucuucuugggaaggcccuuucuggcgguuuauacccugugucugcagugcugugugacgaugagauaaugcug


accauuaaaccaggcgagcacggcuccacauacggcggaaacccacuaggcugccgaauugccauugcggcucuugagguu


uuagaagaggagaaucuugcugagaaugcagacaagaugggcgcuauccugaggaaggagcucaugaagcugcccucugac


guugugaccucagugagagggaaaggguugcuaaaugccauugucaucagagaaaccaaagacugugaugcuuggaaggu


gugccugcgacuucgagauaacgggcuucuggccaagccaacccacggugauaucaucaggcuugccccuccccuugugau


caaggaggaugagauccgggaguccguggagaucaucaacaagacuaucuuguccuucugagaguaggaacucuggggagc


caucuucagacagggcucuugugaaacucugcuugcaguggccagagccugucuccugaaaggcauauauuucaguugau


gcauaauagagugacaccuaggaaccugcagguggcugcgugacagaaaagugagagcgagaggcgaggcgucucuuugu


ugagguuugacugugugggaacuuucuaaggagaaacggacccaucugcguacagccugcagauggaggccugcagucau


uuacgugcgucuuuacaguuuccuugcugaugugaaugguuuguauuuagaaguuauuucugagauacuacagaacaguu


aaaucauuauaaucaaugaauguuaaguugauugaagguuaagcauauguaaaauacuaguuuaaaguaaacuuuucauug


gccaacaccagaauguauuauauagauucugagaauucauuacuaaauuacacuuugcuugauugcaauuuguaaaacauu


uauuuucaguauuucuuugaauaaagcuuaauguuucuuuuuacgccaacagaguauuuuguauuuccauuuugguaaua


aucaguguauuauuucauccugaugacuggcauuucaucaccuauugagaucacuggguguguuucaggccuuuuauucu


aaauaaagcuaugaccaguuucugucugu












145
AI843119
uuuuuuuuuuuucuuuuccgacgcccacaagaggaauaagagauuuaaugauggaaagua




uggggaaaucacaguuuucagacaugaguaaucaaaaacuugacauuuuucuugauaucc




aaaucuagaugucuguaucaaaccagaggugauggccuuggggauggcagugaagacugu




uaggaccauuagaucagau





146
A1837786
uuuuuuuuuuuuuuuuuacaguuuuaaaacaauacacagcuuucucgggcugaagcaauu




gcaagaacguauugguauugguauauuacagcuacauacaagguuuaugaauagcaaugg




agaaaaauaaguuauuuaaauauugacuucauaaagagaaagugcaauguuguuaguugu




cauaucacuugcuugacaguuugugggguuucuucccuaucaauuuuaacaaucaagaua




acauggacucaagacagaauuuuucgggaaccucacucaguccucacacagcagugacuu




gggaaucuacguguguuccaccgcaguugugaaacacacuacuccguguccaggacucau




uucucagagaagaaucaauucgaguuccauccacaccuggggucgggacaca





147
U41465
Sequence below.










ccgggcucgaauucucuagacucgaguuuagagaauucgagcucucccaguuuuaaagcaaaauuuuggacugugaagcaa


ggcacugggcaaacacaacauggccuccccggcugacagcuguauccaguuuacccggcacgcuagugauguucuucucaa


ccuuaaucgccuccggagucgggacaucuugacggacguugucaucguggugagccgugagcaguuuagagcccauaagac


agugcucauggccugcagcggccuguucuacaguaucuucacugaccaguugaaaugcaaccuuaguguaaucaaucuaga


uccugaaaucagcccugagggguuuugcauccuccuggacuucauguacacaucuaggcucaaccugagggaaggcaauau


cauggcggugaugaccacagccauguaccugcagauggagcauguugucgacacaugcaggaaguucaucaaggccaguga


agcagaaauggccccugcacuuaaaccuccccgugaagaguuccugaacagccggaugcugaugccccaugacaucauggcc


uaccgaggucgugaggucguggagaacaauaugccacugagaaauacucccgggugugagagcagagcuuuugcuccuccu


cuguacaguggccugucaacaccaccagccucuuaucccauguacagccaucucccgcucagcaccuuccucuucucugaug


aggagcuccgagaugccccccgaaugccuguggccaacccuuuucccaaggagcgugcccuccccugcgacagugccaggca


agucccuaaugaguauagcaggccagccauggaggugucccccaguuugugucacagcaacaucuacucgcccaaggaggc


agucccagaggaggcucggagugacauacacuacagugugccugagggccccaagccugcugucccuucugcucggaaugc


uccauacuuccccugugacaaagccagcaaagaagaagagagaccuucuucggaggaugagauugcccugcauuucgagcc


ccccaaugcacccuugaaccggaagggucugguuaguccccagaguccccagaaauccgacugccagcccaacucacccaca


gaguccugcagcagcaagaacgccugcauccuucaggccucuggcucuccgccagccaagagccccacugacccgaaagccu


gcaacuggaagaaguauaaguucaucguucucaacagccucaaucagaaugccaaacccgagggcucugagcaggcagagcu


gggucgccucuccccucgagccuacccugcaccgcccgcuugccagccgccuauggagcccgcgaaccuugaucuccagucc


ccgaccaagcucagugccaguggggaggacucuaccaucccccaagccagccggcucaauaaucucgugaacaggucccugg


gaggcuccccccgaagcagcagugagagucacucaccacucuacaugcaccccccaaagugcacauccugcggcucucaguc


cccacagcauacagagaugugccuccauacugcugggcccacguucccggaggagaugggggaaacccagucagaguauuc


ggauucuagcugugagaaugggaccuucuucugcaacgaaugugacugccguuucucugaggaggccucgcucaagaggc


acacgcugcagacgcacagugacaaaccauacaaaugugaucgcugccaggccuccuuccgcuacaagggcaaccucgccag


ccacaagacuguccacacgggugagaaacccuaucgcuguaacauuuguggagcgcaguucaaucggccagccaaccugaag


acccacacucgaauucacucuggagaaaagcccuacaaaugugaaaccuguggggccagguuuguucagguggcccaccuc


cgugcccacgugcucauccacacuggagagaagccguaccccugugaaaucuguggcacucgcuuccggcaccuucagacu


cugaagagccaucugcgcauccacacaggagagaaaccuuaccauugugagaaguguaaccugcacuuucgucacaaaagcc


aacugcgacuucauuugcgccagaagcacggcgccaucaccaacaccaaggugcaauaccgcgugucggccgcugaccugcc


uccggagcuccccaaagccugcugaaugaagcauggaguguuccucgcccuuuccucuccagccccuucucagaaucuaccc


aaaggaugcuguaacacuuuauacaaaggucaucccaugauguagugccucucucauccacuagugcaaaucauaguuggg


guggggguggg












148
U70494
ucgcgguccgacggaggagugggcgcugggaucucgcugagcguccgccuggccucgucu




cuuccucgcucgucggagcuucagcacgguccgagauggcuggcgguaaggcuggaaagg




acuccggaaaggccaagacaaaggcgguuucccgcucgcagcgagccggcuugcaguucc




cugugggccguauucaucgacaccugaaaucuaggacaaccagccacggacgugugggcg




cgaccgccgcuguguacagcgcagccauccuggaguaccucaccgcagagguacuugagu




uggcaggaaaugcgucaaaagacuuaaagguaaagcguaucaccccucgucacuugcagc




uugcuauacguggagaugaagaauuggauucucugaucaaagcuaccauugcugguggug




gugucaucccacacauccacaaaucgcugaucgggaagaaaggacaacagaagacuguuu




aaggaugccuggauuccuuauuaucucaggacucuaaauauuccuaacagcuguccagug




uuggugauuccaguggacuguaucucugugaaaaacacaauuuugccuuuuuguaauucu




auuugagcaaguuggaggcuuaauuagccuuccaaccaaccaaauuucugcauucgaguc




uuaaccauauuuaaguguuacuguggcuucaaagaagcuauugauucugaaguagugggu




uuugauugaguugacuguuuuuaaaaaacuguuuggauuuuaauugugaugcagaaguua




uaguaacaagcauuugguuuuguacagacauuguuuccacucugguggauaagcucaaua




aaggucauaucccaaacuagcuuuaaacuugcuuaauaaucgggucuuaccuuagaucuc




acucagcaacaaguacauucucugcuuacuaauuaaacagugcaucuguagucauaaaaa




aaaaaaaaaaaaaaaaaaaaaaaaaaaaa





149
D17666
Sequence below.










caccaccgugcacgcagcuccgggcccgugggguguugguucuugcccucguaacccccucuguccagccaccaugauaag


cgccagcagagccgcggccgcgcgucucgugggcaccgcugcgucccggagccccgcagccgcccguccccaggugagaag


cugccaugccuuccggugggggcuccaggcccggacucgagugaggcaggccuugccuucgggucagacucuaggaaaaau


ccggagcgaagggauguaacggaccuucugugggcauuguuggccuucuugcagggcuuuagcuucgaacugugcugagu


cacaauccuuggcguuccuaagucuuuaccccgcuaauugagacgucuguccccccucuaaccugugcgcuuugaaugugc


cuggacuuaggcaguggacguaguuuacuggaaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnuuuuacauacuaaggacuaaag


cuugcauguguuccucagaauaugaaaagcccaaguucuuguguaguugauggcugaugcaacuuuuuuccccccaggau


ggcuggaauggccuuagccaugaggcuuuuagauuuguuucaagaagagauuaugcguaaguacaaccucaguuucucug


agaaaaaaaaaaaacacuuauugaaccucaaagcuuggauggguugggugcguuauacauuuguacuuguaguuuauucaa


uaugccacugguaacaccaacauaaaacacaguucuucguauuggagaccacuguucagaugaccauggaauuucauuucu


uacagaucagaagcaaucaagggugcagugguugguauugauuuggguacuacuaacuccuguguggcuguuauggaggg


caaacaagcaaaggugagcaugauuggaaaccugaggucacuuagauacccagucuggcauuaaguacauaggaaugcuga


gucggagcccagguuaguggugggcacuuuaauccuaguaaaggcagagggaucucugaguucaggaccagccuagagua


caaagugagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnacuuuaaucagugucuuugggaauuuuagguccuggagaaugcuga


aggugccagaacuaccccuucugugguugccuuuacagcagauggagaacgacuuguugguaugccagcaaaacggcaagc


ugucaccaauccaaacaauaccuucuaugcuacuaagcgucuuauuggacgacgauaugaugacccugaaguacagaaagac


acgugaguaauaggaaaaucaguccagaagacuggugcuuugaucaaaguucuguggauaccuugaguucuguggaucac


cuuggaucacuuuuucauuauuucugcuugggaagaaaucacaccaccaucagaggcauauagguuuuuuuuuuguuauu


ucuuuguuguuguuguuuuccuauuuauuuguuuguuuguuuggggggggguuucuuuguguauuuuccuggaacuca


uucuguagaccaggcuggnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnucaugugauauaugaugaacuuagagugguuaaguuu


cacagggauaguuuacuuacauaaucuuucugucuuuaaguaagaauguuccuuuuaaaauuguccgugccuccaauggu


gaugcuuggguugaggcucauggaaaacucuauucuccaagucagauuggagcauuuguguugaugaagaugaaagagac


ugcagguaaguggauuuauuucacauuuaggaaaauuggaaugugcuguuuauuucucugcauuaauacugauuaacuuc


auauucuguagauaauggagucugaagcuunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngaauucaugcuccuccugcugccucc


ugggugcuaaguugcaaggugauagcucagguacucacucuagugucuuucuuggggugcucuuuuccaaggccucucua


cauauuaagccacaaaggagucuguugccccucaagaggaugagauguggaauauuaggcuacaguuuuguugccuuuuu


uuuauuuuccuaacaugguaccacaauugaauuuuauucuuuguuucccagaaaauuacuugggccacacagcaaaaaaug


cugugaucacagucccugcuuauuucaaugauucacagcgacagguaaaauuagaucucuuguuugcugggaguggaggu


gggguaccugaguuaaaggauggaaagauagauuuauuucuacuuucucuaggccacuaaggaugcuggccagauaucug


ggcuaaaugugcuucgagugaucaaugagccuacagcugcugcucuagcuuacggucuggacaaaucugaagauaaagugu


aaguuggucagaugacguagcauuaccugcauuuacagggguuguguguguguguguguguguguaauuuuacuacaau


uuguguggguccguguguugugguacauuuguacauuuguacauggcauggauauggaugucaaagauunnnnnnnnnn


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


nnnnnnnnnnnnnnaaaccaguaguugguguguuacuaauuuuacuuguuucuguaugacaugcuuauaugauacguua


acaggcaugccacuuagguugauaacuacauucaguuauuaaguauuucaggaaauaucauaguuaauaauuaaacuuuug


gucuuuuaauucguuccuuuguuuuguuccuuggaacuuaacuuacuuauuuauuuuuuagcauugcuguguaugauuu


aggugguggaaccuuugacauuucuauccuggaaauucagaaaggaguguuugaggugaaaucuaccaauggggacacuu


ucuuaggaggggaagacuuugaccaagcuuuguugcggcacauugucaaggaguucaagagagagguuaguuaccacugc


uuagucaccacugguuaagguguaggcguuggguuguugagaauuuuuguuuguuugcauugcuuuuagcuuuguuaau


agcuuuuuuauacuaagguaacuaacuauacuucagauucauggguaaacuaaaccaguuuaguuauauaaucuuagauug


ggaacaaaagaccaagugacaguguuauaguagggagaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnacuacucucucgcagu


cuauauaugucuccuaauccuauuuauagacagggguugauuugaccaaagacaacauggcgcuucagaggguucgggaag


cugcugagaaggcuaaaugugaacuuuccucaucugugcaggugagggauggaaaaaucccaguacugagcauauuugaau


aguguauucuaauuuaccuaaugucaguguagcucuuuacaguuuucuguuggcugaaaacuuggggcaugagcaaagga


acaacuugaugaucaguucuuuucauuugaaugaaugaaguagauuuauggauguguguaucuuuugccugcaugugug


ucuguacuacauuugugcuugguuucuguggcggccagaagaggguaucagaacugacaugucaguguuggggannnnn


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


nnnnnnnnnnnnnnnnnnncacacugagucuaaauucugaucaugucuuucagucguguuauguuacuuugagugagua


ucaaagaucacgucucccaucugacgugugguccugugcagacugacaucaacuugccauaccuuaccauggaugcuucug


gaccaaagcauuugaauaugaagcugacucgagcucaguuugaaggcauugucacagaucuaaucaagagaacuauugcuc


cgugucagaaagcuaugcaggaugcagaagucagcaagagugacauaggagaagugauucugguugguggcaugacaagg


augcccaagguauggacucaugguauuucuccuagaggaaaaaaauaacaaugcauucuugaggcaaauggcuuguguugu


guguggaaacaaaugugauccauucuucuaguguucuuuaaagaguggugagaccagacucaccaaaaagugcuuuuaguc


gccugugauggcucauguaggaggauggccuugaguucuggguaagaugcagcuacagaauucuaccuugcacacacacu


uaaacccagucugguaaagagaaguuguuaagcuunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncagauguaaaauugauaauac


uucuuccuaagauugggcgauuguguagaauaugagaacuguauuuuauaaccccuugucaugugccuucuauuucaaau


gauauccucugggaagcuagauaauuaaauucuucucucauuuaaguggacaguggaugagaugcucugaaguugucaaa


uacaaacaagucugcagucuuggauaugaaucucucugacuugcugucuggcaggcguauucuguuuggcuccaucaguc


gcccuggguguuggcuaacagguucuuucucccugaugcuuagguucagcagacuguacaagaucuuuuuggcagagccc


cgaguaaagcuguuaauccugaugaggcuguagccaucggagcugccauccagggagguguguuggcuggugacguuaca


gacgugcugcuccuggaugucacuccccucucucuggguauugagacucugggaggcgucuuuaccaaacuuauuaauag


gaacaccacuauuccaaccaaaaagagccagguaagagccauucuuuuuuccugccuauuaacagucccaaguuguacaagu


gcuguuuacaaucacuuuaugaacucuuuaaaacuuuguuucuaagacuauacuaacuggacugggugnnnnnnnnnnnn


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


nnnnnnnnnnnnccuagguguuuucuacugcugcugauggacaaacucaaguagagauuaaagugugucagggggaacga


gagauggcuggagacaacaaacuucuaggacaguucacuuugguaaguguuuuugagucugaguaucaugcuuuuggggu


cuauagcuugcaaagcuccaaacugcugacauuacaggcauauuguguuauuuuuuaaaaagaacguuauguacaugaguu


augaaacccaugauuuuaguuuuuuaccuaaagugcuuuguguuuucagaauuugaaauuuucaaagccugggaaauguu


cagacucagaagcaaugcuaacucagaaguuaguuuuauccugauuacucauuuuaaaaaacuuaauagcuacugguucug


gucagcauugcuacaguagagaaguuuauuugcuguaaauucugggcacauauaaccaucaugguuauuaacuucuugaa


gcccagugauuucagaaagcacuaaaacuaccaccaucacuuaaaaucucaagguuuugaacauucagugaagauacuuguu


uuaggaaacaagugguuaguuggccugauuuggaaaugagaauacaugggccuuucaaaggagcucacucuggauauuua


uuuuagauuggaauucccccagccccucguggagugccccagauugaaguuacauuugacauugaugccaaugggauugu


gcacguuucugccaaagauaaaggcacuggucgugagcaacaga












150
X14897
Sequence below.










auaaauucuuauuuugacacucaccaaaauagucaccuggaaaacccgcuuuuugugacaaaguacagaaggcuuggucac


auuuaaaucacugagaacuagagagaaauacuaucgcaaacuguaauagacauuacauccauaaaaguuuccccaguccuua


uuguaauauugcacagugcaauugcuacauggcaaacuaguguagcauagaagucaaagcaaaaacaaaccaaagaaaggag


ccacaagaguaaaacuguucaacaguuaauaguucaaacuaagccauugaaucuaucauugggaucguuaaaaugaaucuu


ccuacaccuugcaguguaugauuuaacuuuuacagaacacaagccaaguuuaaaaucagcaguagagauauuaaaaugaaaa


gguuugcuaauagaguaacauuaaauacccugaaggaaaaaaaaccuaaauaucaaaauaacugauuaaaauucacuugcaa


auuagcacacgaauaugcaacuuggaaaucaugcaguguuuuauuuaagaaaacauaaaacaaaacuauuaaaauaguuuua


gaggggguaaaauccagguccucugccaggaugcuaaaauuagacuucaggggaauuuugaagucuucaauuuugaaaccu


auuaaaaagcccaugauuacaguuaauuaagagcagugcacgcaacagugacacgccuuuagagagcauuacuguguauga


acauguuggcugcuaccagccacagucaauuuaacaaggcugcucagucaugaacuuaauacagagagagcacgccuaggca


gcaagcacagcuugcugggccacuuuccucccugucgugacacaaucaauccguguacuugguguaucugaagcgcacgcu


gcaccgcggcacugcccggcggguuucugggcggggagcgauccccgcgucgccccccgugaaaccgacagagccuggacu


uucaggagguacagcggcggucugaaggggaucugggaucuugcagagggaacuugcaucgaaacuugggcaguucuccg


aaccggagacuaagcuuccccgagcagcgcacuuuggagacguguccggucuacuccggacucgcaucucauuccacucgg


ccauagccuuggcuucccggcgaccucagcguggucacaggggccccccugugcccagggaaauguuucaagcuuuucccg


gagacuacgacuccggcucccgguguagcucaucacccuccgccgagucucaguaccugucuucgguggacuccuucggca


guccacccaccgccgccgccucccaggagugcgccggucucggggaaaugcccggcuccuucgugccaacggucaccgcaau


cacaaccagccaggaucuucaguggcucgugcaacccacccucaucucuuccauggcccagucccaggggcagccacuggcc


ucccagccuccagcuguugacccuuaugacaugccaggaaccagcuacucaaccccaggccugagugccuacagcacuggcg


gggcaagcggaaguggugggccuucaaccagcacaaccaccaguggaccugugucugcccguccagccagagccaggccua


gaagaccccgagaagagacacuuaccccagaagaagaagaaaagcgaaggguucgcagagagcggaacaagcuggcugcagc


uaagugcaggaaccgucggagggagcugacagaucgacuucaggcggaaacugaucagcuugaagaggaaaaggcagagcu


ggagucggagaucgccgagcugcaaaaagagaaggaacgccuggaguuuguccugguggcccacaaaccgggcugcaagau


ccccuacgaagaggggccggggccaggcccgcuggccgaggugagagauuugccagggucaacauccgcuaaggaagacgg


cuucggcuggcugcugccgcccccuccaccacccccccugcccuuccagagcagccgagacgcaccccccaaccugacggcu


ucucucuuuacacacagugaaguucaaguccucggcgaccccuuccccguuguuagcccuucguacacuuccucguuuguc


cucaccugcccggaggucuccgcguucgccggcgcccaacgcaccagcggcagcgagcagccguccgacccgcugaacucgc


ccucccuucuugcucuguaaacucuuuagacaaacaaaacaaacaaacccgcaaggaacaaggaggaggaagaugaggagga


gaggggaggaagcaguccggggguguguguguggacccuuugacucuucugucugaccaccugccgccucugccaucgga


caugacggaaggaccuccuuuguguuuugugcuccgucucugguuuucugugccccggcgagaccggagagcuggugacu


uuggggacaggggguggggcggggauggacaccccuccugcauaucuuuguccuguuacuucaacccaacuucuggggau


agauggcuggcuggguggguaggguggggugcaacgcccaccuuuggcgucuugcgugaggcuggaggggaaagggugc


ugaguguggggugcaggguggguugaggucgagcuggcaugcaccuccagagagacccaacgaggaaaugacagcaccgu


ccuguccuucuuuucccccacccacccauccacccucaagggugcagggugaccaagauagcucuguuuugcucccucggg


ccuuagcugauuaacuuaacauuuccaagagguuacaaccuccuccuggacgaauugagcccccgacugagggaagucgau


gcccccuuugggagucugcuaaccccacuucccgcugauuccaaaaugugaaccccuaucugacugcucagucuuucccuc


cugggaaaacuggcucagguuggauuuuuuuccucgucugcuacagagcccccucccaacucaggcccgcucccaccccug


ugcaguauuaugcuaugucccucucacccucacccccaccccaggcgcccuuggccguccucguugggccuuacugguuuu


gggcagcagggggcgcugcgacgcccaucuugcuggagcgcuuuauacugugaaugaguggucggauugcugggugcgcc


ggaugggauugacccccagcccuccaaaacuuucccugggccuccccuucuuccacuugcuuccucccuccccuugacagg


gaguuagacucgaaaggaugaccacgacgcaucccgguggccuucuugcucaggccccagacuuuuucucuuuaaguccuu


cgccuuccccagccuaggacgccaacuucuccccacccugggagccccgcauccucucacagaggucgaggcaauuuucaga


gaaguuuucagggcugaggcuuuggcuccccuauccucgauauuugaauccccaaauauuuuuggacuagcauacuuaaga


gggggcugaguucccacuaucccacuccauccaauuccuucagucccaaagacgaguucugucccuucccuccagcuuucac


cucgugagaaucccacgagucagauuucuauuuuuuaauauuggggagaugggcccuaccgcccgucccccgugcugcaug


gaacauuccauacccuguccugggcccuagguuccaaaccuaaucccaaaccccacccccagcuauuuaucccuuuccuggu


ucccaaaaagcacuuauaucuauuauguauaaauaaauauauuauauaugagugugcgugugugugcgugugcgugcgug


cgugcgugcgugcgagcuuccuuguuuucaagugugcuguggaguucaaaaucgcuucuggggauuugagucagacuuu


cuggcugucccuuuuugucaccuuuuuguuguugucucggcuccucuggcuguuggagacagucccggccucucccuuua


uccuuucucaagucugucucgcucagaccacuuccaacaugucuccacucucaaugacucugaucuccggunugucuguua


auucuggauuugucggggacaugcaauuuuacuucuguaaguaagugugacugggugguagauuuuuuacaaucuauauc


guugagaauuc












151
AJ006289
Sequence below.










caccugauucccggaggcccgagcccuuagucugggcgggguggcgcgggccggaaggacgccaucccggccugggccaug


gaggcucccgcaccgucccucacggaggaggauuugacugaagugaagaaggacgcuuuagagaauuuacguguuuaccug


ugugagaaaaucauagcugagagacauuuugaucaucuacgugcaaaaaaaauacuaaguagagaagacacugaagaaauu


ucuugccgaacuucaaguagaaaacgggcugggaaguuguuagacuacuuacaggagaaccccaggggccuggacacccug


guggaauccauccgcagggagaaaacacagagcuuccugauucagaagauaacggaugaggugcuaaagcuucggaauaua


aaacuggagcaccucaaaggccugaagugcagcagcugugagcccuuugcagccggagccaccaacaaccucucuaggugca


auuccgaugagagcaaucucucugagaaacagagagcauccacugucauguaccacccggagggagaguccagcacggcucc


cuucuucucuauggcgucgucccugaacuugccaguccuggaaguuggcaggacugaaaacagcagcuucucuucagccac


ucuuccucgaccuggggacccuggggcucccccuuugcccccagaccuucgguuggaagaggggggaaguuguggaaacu


caagugagauguuucuccccuuacggucacgggcucuuucacgccaaugauacaucaccgccuaguuguuuuacuagugau


gcaaaaugcugugaaggaggccaucuuucuauacaaaccacggugacaggucacucacauucgaugcgugccuuuaaaauc


aguguacacauucucuguaaauaggauuuguuaggguaaagaagcgcucuggggcggcgugguguaaucaugguggucgu


gacuuuuccauaauguccuuucuuuuuuauuauuuuuagguguuugcguauuuugaacuuuucauaagauuaauuuuau


cggaauauuucucaauuugagaaaacaacuuguggauugggaauaauguuuuuagcacauuuaugcuacaaauuuucagu


cugauuguuuuucccacugaucuggcaguauauuuuagcaguaagcuguugugugucaggaaagcuggacacgggaaagc


ugccgacacacucagcagugucccacuccuuaguucugagaagccgucggguucugaggagacaccugguggcacugagcc


uggugaccucagugggccaaaauuuguuuuauacucacccugccagcgugagugucuuacuuucacaggccuuguguccu


cagucuuaucuuaaaggauguuaucuuggcagggcaucacuuguaauuaauggaugauacuuguaauugacuaaaguccu


cgcucugagccguuuguucuggcuccgagagcgcugacaugugaagcauggugagcagcgagggaacugacaggaugugg


ccguggccaguguggcuuuaguguuugcaucaggcagccaccagcuccauccguguucuuacugcuuuacaaaguuugac


uaacuuuacacauuuuaaaaaugcugauugucuucguuuaaauuauaauuuuaccuauuucuugacaucuaacuccuauuu


auuucuauuauuuaaaaauuaagaaaugaaaauuugcuauuaacaauaaaguuuuuuuaaugu












152
X12944
Sequence below.










ggggggggggggucagcgccgacguccccugccgccaccaugcccaaaagaaaggcugaaggggaugcuaaaggagacaaa


accaaggugaaggacgagccacagagaagaucugcaagguugucugcuaaaccugcuccuccaaagccagagcccaaaccua


aaaaggccccugcgaagaagggagagaagguacccaaggggaagaaggggaaagcugacgccgggaaggaugcgaauaauc


cugcagaaaauggagaugccaaaacagaccaggcacagaaagcugaaggugcuggagaugccaagugaugugugugcauuu


uugauaacuguguacuucuggugacuguacaguuugaaauacuauuuuuuaucaaguuuuauaaaaaugcagaauuucgu


uuuacuuuuuuuuuuuuuuuaagcuauauuguuagcacacagaacacuucauuacugggugggggaaggaucauguguca


guaacaaaaucucucccaagcuggauugaggacagaaaaccucuuucccugauaauuuuggaaggcuccuguuggcuccca


ggagagagauccuggucuugaccuagguggccaccaaggcacaacaaugccuuguggucugggaaaacuauaaauucacuu


uuauauccucuucccccuguacuaucaacauagacuuaauucccuuaaaaaccagagaccuguuggaaccuggcccccaaaa


uugguuucccaguccauugagugauggggacuuugcagugacuucauugaguguucucaaaagagcacugguuccuuuua


uaaaagauuguggaucuucagauugauaauucugccuaaaagucagggucggcuugugaaaaguuguuaaaacaacauccu


uaaugugaaaugucaacccucacucuaagcuacuucccccuuuucaaagcauugaaugaagacuucauuggguuuuauagu


ggcuuucugauuuugguagucauaucagaagggaauuuggaaguucuuguauauuguugcauugucugcccauguccug


ccugaauaccaugauuguuuaugaaagaaucuuaauaaagcugguuacaguuaggcuggaaaa












153
AW061302
uuuuuuuuuuuuuuuuuggaaguccauaaguaguuuauugucuucaagacuacagugugg




auuccucucccagagaagggucuuucagaggcaggggacugucacccaggugcaggccgu




cuacuugucauuuucauacauggcuggauucuuccuuuucgacugcucaaacuccugguu




gccccauguguagaucagguagaccacuacaaacggcggcgccacgcgcaggaugcgcuc




gcgagugcggcgcaacacguuggggaugccuuugcugaaauagcuugggaaggcgcgcug




cucaaagggcgacaagcugua





154
U67328
Sequence below.










caugaagccagagauguggaagaugugucuagacugcaucaaugaacugauggauacguuggaugcacauuccaacaucuc


ugucggagagaacauuuuggcagagagugagaacuuacacaacuuugaucaguucacuccguguacgacgcugcauccuaa


cuuugguggagcgaauggaugaagaauuuaccaaaauaaugcaaaauacugauccucacucccaagaguauguggagcacc


ugaaggaugaggcacaagugugugcaucauugagcgagugcagcgcuaccuggaggagaaagguaccacugaggagaucu


gccagaucuacuuaaggcgcauccugcacacguacuacaaguuugacuacaaggcccaucagcggcacguuacuccuccuga


aggauccucaaagucugagcaagaccaggcagaaaaugagggugaggacucagcugugcuaauggaaagacugugcaagua


caucuaugccaaggaccguacagaccggauccguaccugugccauccucugccauaucuaccaucaugcgcuccacucccgc


ugguaucaggcccgugaccucaugcucaugagccaccuacaggacaacauucagcacgcagacccgccggugcagauccugu


auaaccguacuauggugcaacugggcaucugugcuuuccgccaaggccugacaaaggaugcacacaauggcacuucuggau


auucagucaagugguggugccaaggagcuucuaggucaggguuugcugcugcgcgcuugcaggagcgaaaucaggaacag


gaaaagguagagcgacgccggcaggugcccuuucaccugcacaucaaccuggagcugcuggagugugucuaucugguguca


gcuaugcuccuggagauccccuacauggcugcccaugagagcgaugcccgccgacgcaunaucagcaagcaguuccaccacc


aacugcgggugggcgagcggcacgcccugcuagguccucccgagucaaugagggagcauguggucgcugccuccaaggcca


ugaagaugggcgacuggaagaccugccacaguuucaucauuaaugaaaagaugaaugggaaagugugggaccuuuucccug


aggcugacaaaguucgcaccaugcuaguucggaagauccaggaagagucucugaggaccuaccuuuuuaccuacagcagug


ucuaugacucaaucaguauggagacacuaucagauauguuugagcuggaucuacccacuguucacuccaucaucagcaaga


ugaucauuaacgaagaauugauggcuucccuggaccagccgacacagacuguggugaugcaccguacugagcccucugccc


agcaagaaacuuggcucugcaagcuggcugagaaaacuuggcacccuaguggagaauaauggacggguguuugaccaaaaa


cagggaaccuaugguggcuauuuccgagaccccaaggguggcuaccggaaaaauggaggcuaaaugccccgugguggcuac


ccccagcaacagucucagacaaccuccugaguuccccacuucagucacccuguggacagaccaucuaaccuuuuucuccuaa


cucaccccaaucauuaaagaucuuuugaggaauuaaaaaaaaagaaagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa


aaaaaaaaaaaaa












155
AI604314
uuauuaauuaaaaaacaauuuauugaaaaagaguagugcuuuguacaaauucccauugca




gcccccagauaucaacugaucucuuuccagcuuugguaguaggguauaaaaauaucaaaa




cuagguaaguucugauguaagauuucuaugggauuauuuuagaauauauagauuugugua




guuuggcaaguaucauuucuaugcauuuacauuacauauuaagcacagauucuguggcaa




aacaucuuugcaugauuacuuuacacacacaaauauaguaaaacuuacauaguacaaauu




cacauaagacuccauucugucuauaacuucauccaugugguuuuaccaugaauuauaauu




cuuaaccucuccuauaacugucagcuuccauuuaauuuugaaaguaucacuucacaaaga




gcacuucauuugcuuuuagaguauacauagacu





156
AI845121
cggccgccaagaaguauaacaugcgaguggaagacuacgagccauaccccgaugauggca




ugggguauggcgacuacccgaugcuccccaaccgaucacagcaugagagggauccguggu




aucagugggaccacucagaacucaggaugaacuggggugaaccgauacacugggaccuag




acauguacaucaggaaucguguggacacgucaccuaccccuguguccugngaugucaugu




guaaacaucucuucggcuuuguggcuuucaugguuuucauguucuggguagggcacgugu




ucccuuccuaccagccuguggguccgaagcaguacccuuacaaaaaucuguaccuggagc




g





157
AW047756
uuuuuuuuuuuuuuuuugaugcaaaugucuuuauuuuccacuuaaacaaguuucccuuuu




gcacuggccuguggcacaaaacagauggcuggguggugacauuaacugucaaguuaguga




gaugcagagauggugagacacugcauuugagugcauaauacuuuuauuccagaggaacgc




caugcagcccaguuacaccuuuaggucagaaaggcugaugcgugaccagccucuauugcc




ucccuugguaagaaggacccacaagugcagaguccaacagaugcuggcucugagcugaac




ucagggcauuccaauuaccacuuucuucuucaccuacacagggccugcucagauguccuu




uuuacaacuccauaagcccuuuggccaaagucccugcaguguuuggggaggaccuuccca




cccuucaccagucagugucugaucugguggag





158
AI838021
uuuuuuuuuuuuuuuuuaauaucuguaauaguuuauuucaaagauuugacauuuacaagu




agaggcaccacaugcuaucugacaguaaaauacugcagggacugaaggccaaggagagag




auccacagaagacaggccuguagugcaggcauugcaucgaccuugcccacagugcuuugu




ucccaacucaggacaguacuuuagugcuugcuucauuuacuggaaaaguucacuggacau




aguuuccacuucuucccccacagcuuccagcucagcaaacuuaagcuacuacuccucgau




gcucucauagaggcucuugauuugugucuggaagaacuuggcaagcucuacucguuuggc




uuucagugucggugucagaaguccguuuucaa





159
AW122893
uuuuuuuuuuuuuuuuucugagguauuaaaauaucuagacugaauuuugccaaauguaag




agggagaaaguuccugaagacucugacuacuugcuuauuuuugauugaccuucuaugcuu




augucauuacugccucacaacguguuugauguccuuuaaugauacaaagugagccugugc




cuucauuuucuugcccauuuugguaccccucgugccg





160
M59821
Sequence below.










gcgcccgaacgucuagcagaguaccugcugcuguaagcuugucgucugggcugcaccgcccgucuuaacccauucucgacu


uaacuacucucgucgaacaagcauggaaguacagaaagaagcgcagcgcaucaugacucugucgguauggaagauguacca


cucucgcaugcagcgagguggcuugcgacuccaccggagucugcagcuaucccucguuaugcgcagcgcucgagagcucua


ccucucagccaagguagaagcccaccagcccgaguucccgccaucccgcagggcucuugacccucgccugcacccgccgcgg


gaagccgaaguugcaguggaaguagcgucccccgaagccgugcagccuccggagcccauggauacgcaagaggaagugcug


cgaguccaggagaccccugcgcucugugacccgccccccgcuagagucagccgcaagcgccggagcagcagcgauuugagc


gacaguagugaugccggacugguaccaagcaagaaggcccgucuagaagagguggagggggaggcgacgucggagguucc


cgaucgccugcagcuuccuccggcacaaagcgaaggugccuucccuaaccucgcccgcguccuccaaaggcgcuucuccagu


cuccugaacuguggacccgccgugcccccgccgacgccccccacgugcgaggccaagccagccugccgcccggccgacaaua


ugcucaacgugcuggugcgagcugugguggccuucugagagcucugguggcuucuuucgagcggcgccaccggagcggag


aacgcacacccgaggcgaaggccggcgggggccgugaagaagagccgcggcccgagcugccgagaggccagggcaaggacu


gaggagcgaggggcgcgggcgccuucucccagacgugcguccauaggugcuauuaaaggacugucccuuccuuggcuugg


agaagggacaccuagaucuugaaucucagggucgaacucucuaggggccaggcugcccuuucaaggccguuucacuaccau


ucgcguuucggccccuacaagugggcacgcuugugcaagcggucagaguugcgucaugggacagacgcgggugcuuccug


uugccuugcguggguguggggccugggaggaggccaggguguggacccgcccuagggacugggaagugacuugagucacc


ucgcccccacaggcugcugugggugagccugaacugaaccaaucaaaucugcgcagaguugaaguggcuggagaccccggg


acuggucaaccuagaugaucgccuggcguggaccaccgcgggacgggugggccgcuggucguaguugcugccguagacac


agcuucuucgggcaggaaagaaaauuuuuuuuuuaccagcguguuuaagaaagucuguuuacuuuucccacgguggguug


uuuaauuagcaacuaccuggaguuuuacaaugucagcuaggaaaauaaagaccaucggugu












161
M13805
See above (same Accession Number).





162
AI845886
uuuuuuuuuuuuuuuuugguuccacuuaaguugcauguuuuauuucucccaaucccagca




auagcacagaagcccaucauguccaucccagacugguuucuaguaggcugagaugacagg




gagccucaguaacgcuaauggcacagagggcucccaaaugccaggcacaacugugccucc




acacuggugacugcccagagugcccuggccccaguguguuggcacucagucugacuuuac




aacgcaaccugcaccuuugaaagggacagucugggaguggggagugugagggagugaagc




ucaaacugccuccugucagcucacccuuucaacauuaaacagagaccaagagagaaacag




uuccaauauuucacauauauuucuucuugugcagucuaagccgagaaugccauguaaaug




ggucacugcgaaaugcagcaauuuagu





163
X53157
gucucgggcgagauggcuucaagguuacuucgcggagugggcgcuuuggcggcgcaggcc




cugaggcgcacggcccguggcgcggccgugacccgcuccauggcuucuggaggugguguc




cccacugaugaggagcaggcuacugggcuggagagggagaucaugauagcagcacagaag




ggacuggacccauacaauaugcuaccuccaaaggcagcuucaggcaccaaggaagacccu




aaucuagucccguccaucagcaacaagagaauagugggcugcaucugugaagaggacaac




uguacugucaucugguuuuggcugcacaaaggcgagagucagcgaugccccaacugugga




acccauuacaagcuggugccccaccaaauggcccacugagccccuguguuaucuuuucag




aauguaaagaaaaacuucucucuaauaaagacuagccauugcaccugcuccuccc





164
U19118
See above (same Accession Number).





165
AF062071
Sequence below.










gcgcaccgccygyguygcgcgscagcgucgucuaggugcaucgcgggcccccgcagrwagaaaaauauggcucaggagacu


aaccagaccccagggcccaugcuguguaguacaggauguggcuuuuaugggaauccuaggacaaauggaauguguucugu


uugcuacaaagaacaucuucagagacagcagaauaguggcagaaugagcccaauggggacagcuagugguuccaacagucc


uaccucagauucugcaucuguacagagagcagaugcugguuuaaacaacugugaaggugcugcuggcagcacaucugaaaa


aucaagaaaugugccuguggcugccuugccuguaacucaacaaaugacagaaaugagcauuucaagagaggacaaaauaacu


accccgaaaacagaggugucagagccaguugucacucagcccaguccaucaguuucucagcccaguucuucucaaagugaag


aaaaagcuccugaguugcccaaaccaaagaagaacagauguuuuauguguagaaagaaaguuggccuuacaggguuugacu


gccgauguggaaauuuguuuuguggacuucaccguuacucugacaagcacaacuguccauaugauuacaaagcagaagcug


cagcaaaaaucagaaaagaaaauccaguuguuguggcugaaaaaauccagagaauauaaaauuacuacaugugaagagacug


aaacuuuguuuuuauuuuaauauaucguaggaaaacauuaaagagcagaugcauggccauuuuccuuugauguucuccag


aguuuugcuuuauacuugucugucauauaauugaucuuuuaggauguuuggguguuuguuacaggcagaauuggauaga


uacagcccuacaaauguauaugcccuccccucaguaaaauuggacaaaaauaugcacaacaaauugaaauacacauauacua


ggaacaaaauuuaguuccacgugccaaacuaaaggaaugaaaucucugcauguuugcagcauaucugccuuuugggaaugu


aaucaagguauaaucuuuggcuaguguuaugugccuguacuuaaaaaaaaaaaaaugguacaccagaaaaggacuggcagu


cuacuaccauagucaaacuucaccuuaauuucgacaugacuuuuggaagcaggaagaaagcuacaaaacugguauuuggua


ccaugugugagccugguuaaauuggucuucuaaaagcugucaauuaggacauucugcgaaagguaacaucacaacugguuc


uaagucaaaccaucaagucaacagcagggugccugagauaaucuuggaagcuuauugugcuggccugcaccagaagauauc


ugcauucucauuacuaaaauuguagcacagaacugcacuaggauuuguuuacaaggagaaauuaaacucuguuugguuuuc


acauauagcagcucuguuaaauaacaugcaucugaauuuuaaguugcaaagguaucugaacaguuaauuuuucaugugcau


cuuuuguugaauguuuugguucaagaaagaauguuuaaagcuuuuuaaagacuucaguucuuaauguaacuguacccuuc


ugcauggaaaaucauaaccaacauggcugcaguagacuucuuuagugguauccagcaccacuugcagagggcugcuuuauc


auauuguacuuggguguaggacucuaguguucuuggguguauugcaugggcugcauuaucuacagcauuguacaauaaca


acuagaaaaggcgguauacuucacugaugcuugucugguaauaucacuucuguguuaaaauggaagguuuuuugugaugu


augaaacuuguguuuuuuauauauaaaugaguauaguuagauuaguguugugguaaugccuguuuucaucuguaaauag


uuaaguauguacacaacaaggcacuacuucugauuuuugcaguguucaguccuaguuuuucuuuauuaaaacauugaguu


uugcuucaauuuuauguaccuuaguucuaaguuagauuugcagauguguacagauaguucauauuuauguauugcacaua


aucaugcuauucagcauugaugcuauauuguauuauguaaauaauaaaagcaguguacagagggaaaa












166
U10404
augacagaugccgcuguguccuucgccaaggacuucuuggccgguggaguggccgcagcc




aucuccaagacagcgguagcacccaucgagagggucaagcugcugcugcaggugcagcau




gccagcaagcaaaucacggcagauaagcaauacaagggcaucauagacugcgugguucgu




auccccaaggaacagggaguccuguccuucuggcgugggaaccuggccaaugucaucaga




uacuuccccacccaggcucucaacuuugccuucaaagauaaauacaagcagaucuuucug




ggugguguggacaagaggacccaguucuggcgcuacuuugcagggaaccuggcaucaggu




ggugccgcuggggcuacauccuugugcuuuguguacccucuugauuuugcccguacccgu




cuagcagcugaugugggcaaagcuggagcugaaagggaauucaaaggccuuggugacugc




cugguuaagaucuacaaaucugaugggauuaagggccuguaccaaggcuuuaauguguca




guacagggcauuaucaucuaccgagcugccuacuuugguaucuaugacacugcaaaggga




augcucccagaucccaagaauacucacaucuucaucagcuggaugauugcacagucuguc




acugcugucgcuggccugacuuccuauccuuuugacacgguucgccgucguaugaugaug




cagucuggacgcaaaggaacugauaucauguacacaggcacgcuugacugcuggcggaag




aucgcgcgcgaugaagggagcaaggcuuuuuucaagggcgcaugguccaacguucucaga




ggcauggguggcgccuuugugcuugucuuguaugaugagaucaagaaauacacauaa





167
U07634
Sequence below.










cguagaaguugucucugucggcgggcgggcgggcaggauuggggcaccgagaccggcgugcggacagcagggaucgcggg


gagcgaggggugcggcauggagcuccgggcagucgguuucugccuggcgcugcugugggguugcgcgcuggcggccgcg


gcggcacagggaaaggaaguuguuuuguuggacuucgcagcaaugaagggagagcucggcuggcucacgcaccccuaugg


caaagggugggaccugaugcagaacaucauggacgacaugccuaucuacauguacucggugugcaacgugguauccggcga


ccaggacaacuggcuccgcaccaacuggguguaccgggaggaggccgagcgcaucuuuauugagcucaaguucacggugcg


agacuguaacagcuucccggguggcgcccaugccugcaaagagaccuucaaccucuacuaugcagagucagauguggacua


uggcaccaacuuccagaagcgccaguucaccaagauugacaccaucgccccugacgagaucacggucagcagugacuucgag


gcucgcaacgucaagcugaacguagaggagcgcaugguggggccccuuacccggaagggcuucuaccuggccuuccaggac


aucggcgccugcgugcggcugcucuccguucgcgucuacuacaagaagugucccgagaugcugcagagcuuggccugcuu


ccccgagaccauugcugucgcuguuuccgauacacaaccccuggccacgguggccgguaccugcguggaccaugccguggu


gccuuaugggggcgagggggcucucaugcacugcacgguggauggcgaguggcuggugccauccgagugccugugccagg


aaggcuacgagaaggucgaggaugccugccgagccuguucuccaggauucuucaagucugaggcaucugagagcccuuccc


uggaguguccagagcauacccugccauccacagagggugccaccuccugccagugugaagaaggcuauuucagggcaccug


aggacccacuguccaugucuugcacacguccacccucugccccuaacuaccucacggcaugcaugggugccaaaguagaacu


gcguuggacagcucccaaggacacugguggccgccaggacauugucuacagugucacuugugaacagugcugcgcagaguc


uggcgagugugggcccugugaggccacggugcgcuauucagaaccuccucacgcccugacccgcacgagugugacagucag


ugaccuggagccccacaugaacuauaccuucgcugucgaagcacgcaauggcgucucaggccuggugacuagccgaagcuu


ccggacugccagcgucaguauuaaccaaacagagccccccaaagugaggcuggaggaccgaagcaccaccucccugaguguc


accaggagcaucccggugucacagcagagccguguguggaaguacgaagucaccuaccgcaagaagggggaugccaacagc


uauaauggccgccgcacggaaggcuucuccgugacccuggaugaccuugcuccggauaccacguaccuggugcaggugcag


gcauggacgcaggagggccaaggagccggcagcaaagugcacgaguuccagacgcuguccacggaaggaucucgcaacaug


gcggugaucggcgguguggcuguagguguuguuuugcuucugguacuggcaggaguuggccucuucauccaucgaagga


ggaggaaccugcgggcucgccaguccucugaggauguccguuuuuccaagucagaacaacuaaagccccugaagaccuaug


uggauccucacacuuacgaagaccccaaccaggcuguacucaaguuuaccaccgagauccacccauccuguguggcaaggca


gaaggucauuggagcaggagaguuuggagaggucuauaaagggacgcugaaggcauccucggggaagaaggagauaccgg


uggccaucaagacacugaaagcgggcuacacugagaagcagcggguggacuuccugagcgaggccagcaucaugggccagu


uuagccaccacaauaucauccgccuggaggcgguggucucuaaauacaaacccaugaugauuaucacagaguacauggagaa


uggagcgcuagacaaguuccuuagggagaaggauggugaguucagcguacuucaguuggugggcaugcugagggguaucg


cauccggcaugaaguaccuggccaacaugaacuacgugcacagagaccuggcugcccgcaacauccucgucaacagcaaccu


ggugugcaagguguccgauuuuggccugucgcgugugcuggaggaugaccccgaggccaccuacaccacaaguggcggca


agaucccuauucgauggacagccccagaggccauuuccuaccgcaaguucaccucagccagcgauguguggagcuacggca


uugucaugugggaagugaugacuuauggcgaacggcccuuacuggaacugucaaaccacgaggucaugaaagccaucaacg


acggcuuccggcuccccacgcccauggacugcccuucagccauuuaccagcucaugaugcagugcuggcagcaagagcgcu


cccgccggcccaaguuugccgacaucguuagcauccuggacaagcucauccgacgccccgacucccucaagacgcuggcuga


cuucgauccccgaguguccauccggcugcccagcaccagcggcucggagggaguccccuuccguacgguguccgaguggcu


ggagagcaucaagaucgaacaguacacggaacacuucaugguggcuggcuacacggccaucgagaaggugguacagauguc


caacgaagacaucaaaaggaucggagugcgucuuccuggccaccagaagcgcauugccuacagccugcugggacucaaggac


caggucaacacaguggggauuccuaucugaguccauuggggcugucacacaauacuugaagagccacaguggucucccugc


cgaucuggugcuggcccacuggaacuuuauuuauuucuguuuccucgucuaugccucccuaggacucugcaggggcuuuu


ugaaugacaccugccugagccugggaaacuuggauugcuggucagggcucucuuuccccugaaaaggacccagcuaagaac


uuagcaguuugccauggccuucccagcauccccugaggcuaaaguuccaccaagagucgauaucgacgagggacauuucca


aacggaccuccccaucuucauuuggccuccugagaagccacucuggagcugaggcuaagcacuaagcccaggaccauaugac


uagcacuguaccgcccgccccuaguuagaggguagguuuuggacuuggcuggguuguggucacaagcaaucucccagugc


cuuuuacagaccccagucugcccucccgucgagggccagcuucuugcuuuccuagggcccucucaggaugcuuggcugugc


ugagguuuuuauuaaauauauauuuuauacuugcggaaagaaugaguguguggcagggacuugccagggcuggagacaga


ggauccccugcaacaagacauucccgggcugggggcuggcggaccugcaggagacuuuccgccaccaccccgucuccagccc


cuuuggacaaaugucgcugucaguguuacagauuucuuuuauuggguuguuuuuuuguuguauuuuuuugaaccuuaac


uuauuauuuuuuuuauauuuauuguuagaaaaugacuuauuucugcucuggaauaaaguugcagaugguuca












168
X04663
Sequence below.










ccaaaaaccuuaauuuucuuucuuguucgguaccuacauuggaaccaccaaaaacaauuauuucaguaaaccguagccauga


gggaaaucgugcacauccaggccggacaguguggcaaccagaucggugcuaaguucugggaggucauaagcgaugaacaug


gcaucgaccccaccgguaccuaccacggugacagcgaccugcagcuggaccgaaucucuguguacuauaaugaagccacagg


uggcaaguaugucccucgagcuaucuugguggaucuagaaccugggacuauggacuccguucgcucagguccuuuuggcc


agaucuucagaccagacaacuucguuuucggucagucuggggcaggcaacaacugggcuaaaggccacuacacagagggag


cugaguugguugacucugucuuggauguggugcggaaggaggcggagagcugugauugccugcaaggcuuucagcugac


ccacucacuggguggaggcacuggcucuggcaugggcacccugcucaucagcaagauccgggaagaauauccugaccguau


caugaauaccuucaguguggugcccucgcccaaagucucugauaccguggucgagcccuacaaugccacccugucugucca


ucaguugguugagaacacggaugagaccuacugcaucgacaacgaggcccucuacgacaucugcuuccguacccucaagcu


caccacgccaaccuacggagaccugaaccaucucgucucggccaccaugagcggcgucaccaccugccuccguuucccgggc


cagcuuaaugcugaccuucgaaagcuggcugucaacauggugccauucccacgucuccacuucuucaugccuggcuuugcc


ccucucaccagccguggaagccagcaguaccgggcccucacugugccugaacuuacccagcaggucuucgaugccaagaaca


ugauggccgccugcgacccgcgccacggccgguaccucacaguugccgccgucuuccguggacggauguccaugaaggagg


uggaugagcagaugcucaacgugcagaacaagaauagcagcuacuucguggaauggauccccaacaaugucaagacagcug


ucugugacaucccaccgcguggccucaagauggcagucaccuucauuggaaacagcacagccauccaggagcuguucaagc


gcaucucugagcaguuuacggcuauguuccgccggaaggcuuuccuccacugguacacgggugagggcauggacgagaug


gaguucaccgaggcugagagcaacaugaacgaccuggugucugaguaccagcaguaccaggaugccaccgcggaagaggaa


gaggauuucggagaggaggcagaagaggaggccuaacggcagagagcccugcaucagcucaggcugcuuagaucccucagc


cuuucuccaacugcccuuuguccuccaguuucuuucugcugccucugucuuguauuuguuuugcuucuguuuucucauu


ggggguaaauggugccuggcacauggcaggcacucaauaaauauuuguuugugg












169
X61232
Sequence below.










ggcagacaaaagaggccggcagugcagcucgcgggacgcauggccgggcgcggaggacgggugcugcuggcgcugugugc


cgcgcugguggccggcggguggcugcugacgcgugaagcccaggagcccggggcgccagcggcuggcaugaggcgccgcc


ggcggcuccagcaagaggacggcaucuccuucgaguaccaccgcuauccagagcugcgcgaggcgcuggugucgguauggc


ugcagugcaccgccaucagcagaaucuacacagugggcgccagcuucgagggccgggagcuccuggucaucgagcugucug


acaaccccgggguccaugagccgggugaaccugaauuuaaauacaucgggaacaugcauggcaaugaggcgguuggacggg


aauugcucauuuucuuggcccaguaccuguguaacgaguaccagaaaggcaaugagacaauugucaaccugauccacagca


cccgaauucauaucaugcccuccuugaaccccgacggcuuugagaaagccgcauggcagcccgggcagcugaaggacuggu


uugugggccgcagcaacgcccagggaauagaucugaaccguaacuucccagaccuggacaggaucguauauguuaaugaga


aagaaggcggucccaacaaccaccugcugaagaaucugaagaaaauuguggaccaaaauucaaagcuugcccccgagaccaa


ggcugucauucacuggaucauggacauuccauuugugcuuucugccaaucugcacggaggagaccuuguggcuaauuacc


cauaugaugagacacggagcgguacugcucacgaauacaguuccugcccugaugacgcaauuuuccaaagcuuggcucgcg


cguacucuucuuucaacccagucaugucugaccccaaucgaccucccugcugcaagaaugacgaugacagcagcuuugaug


auggaacgaccaaugguggugcaugguacagcguccccgguggaaugcaagacuucaauuaccugagcagcagcaacugcu


uugagaucacuguggagcuuacgugugagaaguucccaccugaagagacucucaaaagcuacugggaagauaacaaaaacu


cccucaucaacuaccuggagcagauacaccgagguguuaaaggguuuguccgugaccuucaggguaacccgaaugccaacg


caaccaucucuguggaugggauagaccaugaugucaccucggcuaaggauggggauuacuggcgauugcuugcuccugga


aacuauaaacuuacagccuccgauccuggcuaccuggcaaucacaaagaaaguggcaguuccuuuuagcccugcuguuggg


guggacuuugagcuugagucuuucucugaaaggaaggaggaggagaaggaagaauugauggagugguggaaaaugauguc


agaaacuuugaauuuuuaagaaaggcuucuaacuaauugcuuucaucuaucuauagacuguaguaagaugcaauguggcuc


uuuucuuuuagguugugugcaguugauauuuaacauugauuuauuuuugaucauuaaguaauaguuacuaaucacguaaa


uacacccggacagaaauauaaugcuggacaucuucauucuacaucaacauucgcuuaaaucauucgaagccucuuuuaacgu


aaugggugacaaugucacuugacagaugcaugagagucacgauauagcugacugugacccugcacugcaaucacauaguuc


cauauaaguuguccuuagucucuugugcugauucacuguauaagcaugauccugguaaugcacuuuggaugggaagaaaa


uguacgugcuuuucagaggggcucugaacagaaugaaaaccuaguucuugcguguacuuugaagaauggaauuguauuag


ucagcuguuaaugccacuucagaaguuugggguuuugucuugauuguagauugg












170
X14309
Sequence below.










gccacggacgccucucugaacggggauccaggcaggauuagagcugccucacugacuacaggccgugucgugucaccguuu


cugcaggcaccaugagccaggacaccgaaguggacaugaaagauguggagcugaacgagcuagaaccggagaagcagcccau


gaaugcagcggacggggcggcggccggggagaagaacggucuggugaagaucaagguggcggaggacgagacggaggccg


gggucaaguucaccggcuuauccaaggaggagcuacugaagguagcgggcagcccuggcugggugcgcacccgcugggcg


cugcugcugcucuucuggcucgguuggcugggcaugcuggcgggcgccgugguuaucaucguucgggcgccgcgcugcc


gugagcugccuguacagaggugguggcacaagggcgcccucuaccgcaucggcgaccuucaggccuuuguaggccgggau


gcgggaggcauagcuggucugaagagccaucuggaguacuugagcacccugaaggugaagggccugguguuaggcccaau


ucacaagaaccagaaggaugaaaucaaugaaaccgaccugaaacagauuaaucccacuuugggcucccaggaagauuuuaaa


gaccuucuacaaagugccaagaaaaagagcauucacaucauuuuggaccucacucccaacuaccagggccagaaugcguggu


uccucccugcucaggcugacauuguagccaccaaaaugaaggaagcucugaguucuuggcugcaggacgguguggauggu


uuccaauuccgggaugugggaaagcugaugaaugcacccuuguacuuggcugaguggcagaauaucaccaagaacuuaagu


gaggacaggcuuuugauugcagggacugaguccucugaccugcagcaaauugucaacauacuugaauccaccagcgaccug


cuguugaccagcuccuaccugucaaauuccacuuucacuggggagcguacugaaucccuagucacuagguuuuugaaugcc


acuggcagccaauggugcagcuggagugugucgcaagcaggacuccucgcagacuuuauaccggaccaucuucuccgacuc


uaccagcugcugcucuucacucugccagggacuccuguuuuuagcuacggggaugagcuuggccuucagggugcccuucc


uggacagccugcgaaggccccacucaugccguggaaugaguccagcaucuuucacaucccaagaccuguaagccucaacaug


acagugaagggccagaaugaagacccuggcucccuccuuacccaguuccggcggcugagugaccuucgggguaaggagcgc


ucucuguugcacggugacuuccaugcacugucuuccucaccugaccucuucuccuacauacgacacugggaccagaaugag


cguuaccugguggugcucaacuuccgagauucgggccggucagccaggcuaggggccuccaaccucccugcuggcauaagc


cugccagccagcgcuaaacuuuugcuuaguaccgacagugcccggcaaagccgugaggaggacaccucccugaagcuggaa


aaccugagccugaauccuuaugagggcuugcuguuacaguuccccuuuguggccugauccuuccuaugcagaaccuaccac


ccuccuuuguucuccccaggccuuuuggauucuagucuuccucuccuuguuuuuaaacuuuugcagauuacauacgaauu


cuuauacuggguguuuuugucuucaaauaaaaacaucaccccugccucaug












171
U42386
Sequence below.







gncuuaagccncguuuauuuugaugnccuguuggcucagunaugnccaagaugccnauuguuuuugcccnaaauaaauuu


acugaacuugggcuaaaaccaaaccuuggcacacaggugugauacaacuuaacaggaaucaucgauucauccauaaauaaua


uaaggaaaaacucaagugguagccugucuuaaggcuuuugauacuugcagauuggggaaaaacaaacaacaaacgucuuga


agcauauuaauggaauuaguuucuaauguggcaaacuguauuaaguuaaaaguucugauuugcucacucuauccuggaua


gguauuuagaaccugauaauagucuuuaaacaagccauuccagucaugaugaggugauguauggauacaugcauacauuca


aagcacuguucucaaaguuaaugcaaguaaauacagcaauuccucuuucaauguuuaggcagaucguuaacuaugagcuag


ccaaaugugggcauguuauuacagggaaaguuuaaaggucugauaacuugaaauagguuuaggagaauucaucuacuuag


acuuuuuaaaugccugccauaaaaaauugaaaugguagaauggcugaccacagcaaugaccagcccucaccuagggcucug


gaugauuuuuggucuaauaacgcaugcuaguguugauguuuuuuggucaagaugggaaugaacaggaagaauuaugcagc


aggcuuuauuuuaaaugccgauucacauuacucuguucaagcugcguugagauguuaaacuggcuuacuauagacuuugu


aaaaaaaaaaaaaaccaaacaaauggcuccagaagaguaacaaacugaaaucugagaucacacagguuggaaauauguacaua


acugaacaaggugucaauucugcucuacagugcaguuuagucaguuuuaguugcauagguuuccauuguuuuuauagucu


guuuaugcuaaaucuggccaaagaugagcauuguccaccacuaaaaugccuaugccacugggaauucuggguuaauuuugu


gaccagaaugcagugaucaaaauguucaaucuuuuuacaguggcauaggaagauggcaaaaauuuccuaaagugcaauaga


uuuucaaguguauugugccuuguucuaaaacuuuuauuaaguaggugcacuugacaguauugaggucauuuguuauggu


gcuauuucaauuagucuagguuuaggcccuuguacauuuggcccauaacuuuuuacaaaguacuucuuuuauugcacauu


cagagaauuuuauauauaugucuugugugcguguccuuaaacuuccaaucuuauuuugucucuuggagauuguugaacgc


agcuugucuaggaaagggaugggacuagauucuaaaauuuauuugggaccaugggaaugauaguugggaagaaacuuugc


acacgacagauuucuagauacuuuuugcugcuaguuuuauguaauauuuauugaacauuuugacaaauauuuauuuuugu


aagccuaaaagugauucuuugaaaguuuaaagaaacuugaccaaaagacaguacaaaaacacuggcacuugaauguugaaug


ucaccguaugcgugaaauuauauauuucgggguagugugagcuuuuaauguuaagucauaauaaacucuuaagucaaauu


aagcagacccggcauuggcguguagccauaacuuucugauguuaguaaaaacaaaauuggcgacuugaaacuaaaucaugc


caagguuugauacacuugucuugagauauuaacgaaacacuuccaaacacugauacaaaguguccagauucucagauguuu


guugugugaguuuuguuuaguuguauuuuuuuuucagugaaugucuggcacauugcaauccucaaacaugugguuaucu


uuguuguauuggcauauucagugacuuguacauucagcaauagcauuugagcaaguuuuaucagcaagcaauauuuucag


uuauguuuccaaauuaagaauggguuuaaacuugcugaauguaaagauugacccucaagucacuguagcuuuaguaguug


cuuauuguauuaguuuagaugcuagcacugcaugugcugugcauauucugguuuuauuaaaauaaaaaguugaacugcac


agucuccuuuguuguugucaauugugguuuacuuuuagaggugaaaauaaaguugugcucuugccucgugccaauaugua


cauaacugnacaaggugucaauncugcucuacagngnaguuuagncaguuuuagungnauagguucccaunguuuuuaun


gncuguuuaugcuaaaucuggccaaagaugagcauugcccaccacuaaaaugccuaugccacugggaauccuggguuanuu


uggngaccagaaugaagugancaaaauguccanucuuuuuacaguggnauaggaagauggnaaaaauunccuaaagugnaa


uagauuuccaaguguuungugccugguncuaaaacuuuunuuaaguagggugcacunganaguauugaggncauugguu


auggugcuauuuccanuuagucuagguuuaggcccu












172
U51126
Sequence below.










cucggucuccaagaugguggcuaacaaaacgugaggccuagagguugauccuaggucacuggaagcauguccuugaagagg


acuaugggcaucuggguucuuccucuucuacuuggccacgagguaaccggcuucuuguaccacgugugcucaccucuacaa


ucugugcggauucagacuccaagcaacuaggcuacccagugacaggcuaaaaacuacagcucuaacgucuuggaaggcgau


uccauggaccaggauguggaaagcccaguggccauucaccagccaaaguugccuaagcaggccagggacgaccugccgagac


acaucagccgagacaggaccaaaaggaaaauccagagguacgugaggaaggaugggaagugcaacguucaccacggcaaugu


gcgggagacguaccgauaccugacggacaucuucaccacccugguggaccugaaguggagauucaaccuguugaucuuugu


cauggucuacacagugacguggcuuuucuuugggaugaucugguggcugauugcguacauccggggagauauggaccaca


uagaggaccccucguggacuccuugugucaccaaccucaacggguuugucucugcuuuuuuauucuccauagagacagaaa


ccaccaucgguuauggcuaccgggucaucacggacaagugcccugaggggauuauucuccucuuaauccaguccguguugg


gguccauugucaacgccuucaugguaggauguauguuugugaaaauaucccaacccaagaagagggcagagacccuggucu


uuuccacccacgcggugaucuccaugcgggaugggaaacugugcuugauguuccgggugggggacuugaggaauucucac


auuguggaggcauccaucagagccaaguugaucaaguccaaacagacuucagagggggaguuuauuccccucaaccagacu


gauaucaacgugggguacuacacaggggacgaccggcucuuucuggugucaccauugauuauuagccaugaaauuaaccaa


cagagucccuucugggagaucuccaaagcgcagcugccuaaagaggaacuggagauuguggucauccuggagggaauggu


ggaagccacagggcaguucugaaaucgaaaucaagcagaggucuauaagaacacccuggagacccccaugcugcuggaucu


uggguccaugaacugcuuuuauuugcugcaaucaaaaaugcuagucgcugaucugauaggagaggaaacgagacucagagc


cugaaggauaacacgcugagggcugauuucauacacucuucccggcuggaucaucccagcccccacagcguccaggcuuag


uuucuuccuuuguuuuaacaaucuauacuuccuccagccugggcgagcuaguauacccagaguuugguuuuguuucuuuu


cagagcuguaagcccagugcccagugaccucaucugggaggagaguuaagcaauaagaccugaaaugcuaaacucuggggu


agaaaaccucugcagagacagcgucucugggaagucucuacagagacagaguagggaagucucacgaaggucagagucuua


cuuccauaccuggagaaauccgcccguccguucagugccgguuucaacuccucugccaaagacuucuuuccaagacacugg


uaucagcuaucccagcaguaacuuuggcaguauauaaaucaauggcacugccccauaaaaccccguugaguaaaaccuaugg


ucuucaacagcuggggagccuguagcccagcuccugugugaggcuaaggcuguggagaccaugccugcucaccuccucguu


gaaaagcaaaacacuguaagaaaccuaacaugacuuuuuccaacauuucucaggcuggggagaagacuugguccacaaagag


cuugaggucuugaucuggaucccuagcauccauggaagaaggugggcaugaucacccacacuccucaucccauagcucuga


augagguaggcagauuccuggggcucaccagcucauccuaacagccaggucccaaugagggacugucuacaaaagaacaaga


gguggauccugagaagcgacacccaagcuugaccucuagccccuguacacaccuguuaagcaccugggcaucgggacacaca


cucgcaauuugcaaacaaggcaaauucucacacuucagaaggcacugagagaaucccauaagcucaaaaaguuaggagccaa


gauugaccauuaaugacuuggguugaaaagacuaaaccacuggauagaauguuucauuacuaaaacaccuuaccugaaaag


uauuacugcucuucuuucugcaacuggaccaugcagagauccacaaagagaugcccagagauuauuagugauggucauaug


auauacacaauguggacucuaagccaaggccccaucaacucagauccagaggcugacagugugcuuaucuuagagauaccac


aguggcugccuaaucaccacguccuuaagucaggggaguuugauuauuuccuaugaacaccgaguggggacagcggauuac


caaugaagcaauccaaccugacaauccuaaccacccagaagaggaucgcugggggaaagcaugaauuauuuacgugucaaca


ugugcacacuccggccacgcagcucaacagccaggagugcuucuccacuuagcccugcccuggcauccauuuaugaucucg


ucuguuguguuaauuacccagcuagcuuuuuucucaaaaauaauaucucccagccauagaccuacucaucuguguccucuu


uaauuucaacccacaguuacaucauucacuggcuugcucaguuucuucaacucugaaaugggaaugaugaugaugaugccu


cuucccccaagccaccauccucccccgugaccuuccuagguacagacucaaaccagggaagauuauuuccuucucauaggcc


acagggugaaaugcaauaaagaacaaagccuuguagggaggcagagggaaagaccaguccucacaagaggcuccauuguuu


ccagggacuuugaagcuuggacagaaugucagaugauccccuuugaaggugcuccaaagagucaaugugaaaaauauugac


ugaugugugcccguccacaagccaaggugccucugcccuggucaccuaccaugaauuauaaacugaugauauuugaaauaa


uaaggaacacuggagccggccagaaaggauucugcagucccauaaauagcaacauucaucacuacaaugccugccaacggug


gccgugaauguagauuacccccggcucuucugaggccacugaggacagggcaaacuaccucugagaauggaggcucacugu


ucugcaucccacuucuaaauguuccaugaauuuuuugagacaucucccauaucccuguuagaaagauucaaccuugugcua


uuaaccaaaucauuuugaauuccauaaaccucuacucuaaaguauacacuuaauucuacaauacagacaacaaauaugacuu


uuuccuaugaaagagugauaaagauacuguaucagucugcuuugacucaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa


aa












173
AF093853
Sequence below.










uggaaugggugcuaggugaaggcuuuguugaaucaggaugcugagcugguguuuuuacagguccagauaugaugagcug


gaguuuugguaggcccagguaccuccuccaaaauugaccacauaauuggucacaaaucaggccuccacagauacaaaaauau


ugaaauuaucccaugcauccugucugaucaccacagacuaaggcugaucuucaauaacaacauaaaaauagaaagccagguu


cacugcugcggcugcgccuccuuguucucagcgucaccacugccgccaugcccggaggguugcuucucggggacgaagccc


ccaacuuugaggccaauaccaccaucggccgcauccgcuuccacgauuuccugggagauucauggggcauucucuuuuccc


acccacgggacuuuaccccagugugcaccacagaacuuggcagagcugcaaagcuggcgccagaguucgccaagaggaaug


uuaaguugauugcucuuucaauagacaguguugaggaucaucuugccuggagcaaggacaucaaugcuuacaauggugaa


acacccacggaaaaguugccauuucccaucauugaugauaagggcagggaccuugccauccuuuugggcauguuggaucca


gucgagaaggacgauaacaacaugccugugacggcccgugugguguucauuuuuggcccugacaagaaacugaagcugucu


auccucuacccugccaccacgagcaggaacuuugaugagauucucagagugguugacucucuccagcugacaggcacaaag


ccgguugccaccccaguugacuggaagaagggagagagcgugaugguaguccccacccucuccgaagaggaagccaaacaa


uguuucccuaaaggagucuucaccaaagagcucccgucuggcaaaaaauaccuccguuauacaccccagccuuaagucuuug


cggaaauuggggcugcaucugcacguccagcacuggggccugaggacgucagccggcagccguggguccuugcagcaggu


ccguagaaagaucguggcaugaucacagccgguccuguagaucgcucgcuauacuacugggucauuaaauggaaauggcac


caaaaccuucucgggauucuuuacucugugccuucgccagcauucugccccucugccugucacagugcccuacugacuggc


ucucuuugaaacgaauuauguauugaagauuccuuaggucucugcagggucuuugaucagcaagcaagguagugucagug


ugggcucugugcuagaaugaugaaacaccuuuuguagcuuuccgaacggaaucuucuguuacccauuuuggagagcacug


acauggggagaagcuuucaauucuguauuuuuaguaaauaaaguggggacagccgggagaauucuuacagggaaucuauu


guaaguuucuaucgaagugggcucagaaagccuuucgccucccaagagugcgcauguaccuccuagaguuuccacaucugc


ucucuggugaugucugccugugaacgcaccuuauaaaagacgggcggugacaguguuuuaccacucaguguccuaguagu


ggguggccauuucugaauucugcuuuuugagguucaacaaauaaaauccugaucagaaaaaaaaaaaaauagaaagccaaca


uucauguggaaacugaacaacacuacucaaugauuccuuggucagagaugaaauaaagaaagaaauuaaagacuuuuuaga


guuuaaugaaaaugaagccacaacauacccaaacuuaugggacacaaugaaggcauuucuaagaggaaaacucauagcccug


agugcauccaaaggaaaaaaaaaaaaaccuagagagaguguacacuagcagccugacugcacacuuagaagcucugcaaaaa


aaggaaucaaauucacccaagaggaauagacagcaggaaauaaucaaacuuagggcugaaaucaaccaaauggaaacaaaaag


aacuauucaaagagugggccaaaccaggagcuaguucuuugagaaaaucaacaagauagauaaacccuuagccagacucacu


agagggcacagggacagcauccuaauuaacaaaaucagaacugaaaagggagacauaacaacagauccugaagaaauccaaaa


caccaccagauccucuacaaaaggcuauacucaacaaaacuggaaaaccuggaugaaaggaaaagcuucuagacaga












174
Z19521
Sequence below.










augagcaccgcggaucugaugcgucgcugggucaucgcccugcuccuugcugcugccggaguugcaguagaagacucagg


cagcaggaacgaguuccaguguagagacggaaaaugcaucgcuagcaagugggugugcgauggcagccccgagugcccgga


uggcuccgaugaguccccaaagacaugcaugucugucaccugucaguccaaucaauucagcuguggaggccgugucagccg


augcauuccugacuccuggagaugugauggacagguagacugugaaaaugacucagacgaacaaggcuguccccccaagac


gugcucccaggaugacuuccgaugccaggauggcaagugcaucuccccgcaguuugugugugauggagaccgagauugcc


uagauggcucugaugaggcccacugcccagccaccacuuguggccccgcccacuuccgcugcaaaucauccauaugcauccc


cagucuuugggccugcgacggggaugucgacuguguugacggcucccaugaguggccacagaacugccaggccgaagacac


ggccuccaaaggcguuagcagccccugcuccucccuggaguuccacugugguagcagugaguguauccaucgcagcugggu


cugugacggcgaggcagacugcaaggacaagucagaugaggagcacugcgcgguggccaccugccgaccugaugaauucca


gugugcagauggcuccugcauucacgguagccgccagugugaccgugaacaugacugcaaggacaugagcgacgagcucgg


cugcgucaaugugacacagugugauggccccaacaaguucaagugucacaguggggagugcaucagcuuggacaaggugu


gcgacuccgcccgcgacugccaggacuggucggaugagcccaucaaggagugcaagaccaacgaguguuuggacaacaaug


guggcuguucccacaucugcaaggaccucaagauuggcucugagugccugugucccagcggcuuccgguugguggaccuc


cacaggugugaagauauugacgagugucaggagccagacaccugcagccagcucugugugaaccuggaaggcagcuacaag


ugugagugccaggccggcuuccacauggacccacacaccagggucugcaaggcugugggcuccauaggcuaucugcucuuc


accaaccgccacgagguccggaagaugacccuggaccgcagcgaguacaccagucugcuccccaaccugaagaauguggugg


cucucgacacggaggugaccaacaauagaaucuacugguccgaccugucccaaaaaaagaucuacagcgcccugauggacca


ggccccuaacuuguccuacgacaccaucaucagugaggaccugcaugccccugacgggcuggcgguagacuggauccaccg


caacaucuacuggacagauucagucccaggcagcguaucuguggcugacaccaagggcguaaagaggaggacacuguucca


agaggcaggguccagacccagagccaucguaguggacccugugcauggcuucauguacuggacagauuggggaacacccgc


caagaucaagaaaggggguuugaaugguguggacauccacucacuggugaccgaaaacauccaguggccaaauggcaucac


acuagaucuuuccaguggccgucucuauuggguugauuccaaacuccacucuaucuccagcaucgaugucaaugggggcaa


ucggaaaaccauuuuggaggaugagaaccggcuggcccaccccuucuccuuggccaucuaugaggacaaaguguauuggac


agaugucauaaacgaagccauuuucagugccaaucgacucacggguucagaugugaauuugguggcugaaaaccucuuguc


cccggaggacauuguccuguuccacaaggucacacagccuagaggggugaacuggugugagacaacagcccuccuccccaa


uggugguugccaguaccugugccugcccgccccacagaucgguccccacucgcccaaauucaccugcgccugcccugaugg


caugcugcuggccaaggacaugcggagcugccucacagaagucgacacuguacugaccacccaggggacauccgccguccg


gccuguggucaccgcaucagcuaccaggccaccgaagcacagugaggaucucucagcucccaguacuccuaggcagccugu


ggacaccccagggcucagcacaguggcgucagugacagugucccaccaaguccagggugacauggcuggcagagggaauga


ggagcagccacaugguaugagguuccuguccaucuucuucccuauugcacugguugcccuccuuguccuuggggccgucc


ugcuguggaggaacuggcggcugaagaacaucacaaucaacagcauaaacuuugacaacccagucuaccagaagaccacaga


ggacgagcuccacauuugccgaagccaggauggcuauaccuaccccucaagacagauggucagccuggaggacgauguggc


augagcagccgggagagccgucucuuuccgggauccauugccaagcuuaggcagaaaagacacucucuccagaccuccccau


ccagcacugguccugccaccucccugggucuguguugcucaaagcaagauagagcaaagcugggcuggggggccaagcuca


gcuuccugucugccccagguucuguuuuauauauuuauugucugggacagaaaaggcuacuggcugugcuugaaauucga












175
U04354
Sequence below.










accggucaucgggcucuuccuugggcucagggcacggaucaaguccucggcucgcucggccagcaccgcggcaccauggcg


caggagcugcagcaccccgaguucgcgcgcgcaggccagcaggcugggcugcagguguggagggucgagaagcuggaacu


gguaccggugccccagggugccuauggugacuuuuacgucggagagcccuaccuggugcugcacaccaccaaguccagcag


gggcuucuccuaccgccugcauuucuggcugggaaaggaguguucccaggaugagagcacagcggcugccaucuuuacgg


uccagauggacgacuauuuggguggcaagccaguccagagcagagagcuucaaggcuaugagucgacugauuuugugggc


uauuucaaaggcggucugaaguacaaggcuggagguguggcuucuggacuaaaccauguccucaccaaugaucugacugcg


aaaagacuucugcacgugaagggucggagaguggucagagccacugaaguuccccucagcugggagagcuucaacaagggc


gacugcuucaucauugaccuuggcaccgaaauuuaccaguggugugguuccuccugcaacaaauaugagcgucugaaagca


agccagguggccauuggcauccgggacaaugagaggaaaggaagaucucaacucauugugguggaagaaggaagugaacca


ucagagcucaugaagguuuuagggagaaagccugagcuuccagauggggacaaugaugacgaugucguagcagacauaagu


aacaggaagauggcgaagcucuacaugguuucagaugcaaguggguccaugaaaguaacacugguggcugaagaaaacccg


uucuccaugggaauguugcuuucugaagaaugcuucauuuuggaccauggugcugcaaaacaaauuuuuguauggaaagg


uaaaaaugcuaacccacaggagaggaagacugccaugaagacagcugaggaguuuuuacagaaaaugaaguauucuacuaa


uacucaaauucagguucuuccggaaggcggugaaacaccaauuuucaaacaguucuuuaaggacuggaaggauaaagacca


gagugauggcuuugggaagguguacaucacggagaaaguggcucagauaaagcagauuccguuugaugccucaaaacugca


caguucuccgcagauggcagcccagcacaacaugguggacgauggcucuggcgggguggagaucuggcguguagagaaca


gugguagaguccagauugacccaagcuccuauggcgaguucuauggcggugacugcuacauuauccucuacacuuauccca


gaggacagaucaucuacacauggcaaggagcaaaugcuaccagagaugaacugaccauguccgcguuucugacuguccagu


uggaccggucccuuggagggcaggcugugcagguccgugucucucaaggcaaagagccugcucaccugcugaguuuguuc


aaagacaaaccacucauuauuuauaagaaugggacauccaagaaagaagggcaggcaccggcucccccuacacgccuuuuuc


aaguccggaggaaccuggcaucuaucaccagaauuguggagguugacguugaugcaaauucauuaaauucuaaugacacuu


uuguccuaaaacugccacgaaacaauggcuucaucuggauaggaaaaggugcuagccaggaggaggagaaaggagcagagu


auguggcugauguccucaagugcaaagcuucaagaauucaagaaggcaaggaaccagaggaauucuggaacucucuuggag


ggaggggagacuaccagacuucaccauugcuagaaacucgggcugaagaccauccaccucggcuuuaugguugcuccaaca


aaacuggaagauucauuauugaagaaguuccgggagaguucacccaggaugaccuggcagaagaugaugucaugcuacuug


augcgugggaacagaucuuuauuuggauuggcaaagaugccaaugaaguugagaaaaaggaaucagugaagucugccaaaa


uguaccuggagacagacccuucuggaagagacaagaggacaccgauugucaucaucaagcaagggcacgagccccccacauu


cacaggcugguuucugggcugggacuccagcaggugguaaaaccagcaacuauccuggcugcauuggggcagcugccacuu


uguuguuggggaauuguuuacuuuuuguuauuggcuuuugaagauaaacuccugccaaauggauauauaucuauaucuau


aucuauaucuauaucuauaucuauaucuauaucuauaucuauaucuaucuauaucuaaucuauaucuaucuaucuaucuau


cuaucuaucuaucuaucuaucuaucuaucuauaugcuccucuuuuccuucucuuucaaagggaauugcuguauguuacua


uacugaaauaaccuaaagcaaccauuuguuuucgagcaauuuugcaaucuggggaccucugaggaaguaauuuugucauuc


agccacugcuagccaaacuugucuuuucccauagagaggaaggagagccacagugcuucuaagcauuuccccgucugcuac


ucuguuugcagugagcuuuacuuuauguauggcuuuaacaaugccuugcuguuucccaucucaagucaaugccacuugga


ugccauucacucccaaguguccuuacauaggaugaacuucuuuagcuuuuuuagaaaacuaaaaucaugucuuuuaugaua


aaacacauuuuauuucuauaaguuuaacuuuauauauuugauagcacaugcucaauagcauaaagaauaugcauugaauga


uguuuuucauaauuaaaauauauccuuuugg












176
M35244
Sequence below.










caggguugagagcaagaaggugcaggauguaggccagcagaauuaucagacccaguggcggcuucugccacuggaagaauu


uccaacauaaaacagaugaucaguuugggacaaucgauucugcgaccagagguagugucaucugguuacuuuuaaaauuca


gauugucugguguuuuccaaucacucgcgacuguaauuugaaguuggauucugagauaauacaaucgcugucgcucuagu


uuauaaagcuguccaagaucugcccagucccagauguccuggguccucagggcggcuguggucugcgcccuucuccugcag


cuggaugccagaccauccuggacucggaucccuuuggguucacacucgcuuagguauuucuacaccgcugugucccggccu


ggccuuggggagcccugguucauaaucgucggcuauguggacgacaugcagguccugcgcuucagcagcaaggaggagac


uccgaggauggcacccuggcuggagcaggaggaagcagaugacugggaacagcagacucauauagucacaauucaaggaca


gcugucugaaaggaaucugaugacccugguucauuuuuacaacaagagcauggacgacucucacacacuacaguggcugca


ggacugcgauguggagccagaucggcaccugugucucugguacaaccagcucgccuaugauagcgaggaucuccccacccu


gagcgaaaacccaaguuccuguacagugggaaacagcacuguaccucagaucucucagcaccuggagggccacugcucagau


gugcugcagaaauaccuggaaaaagggaaggagaggcugcugcguucagaccccccaaaggcacaugugacccgucacccca


gaccugaaggugaugucacccugaggugcugggcccuggguuucuacccugcugacaucacccugaccuggcagaaggaug


gggaggagcugacccaagauguggaguuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugug


guggugccucuuggaaaggugcagaguuacacgugccauguggaccaugaggggcugccugagccccucacccugagaug


ggagccugcaugguaccaaaagccuuggauuuggauuguugccacgguuuuuuccauuuugcucauuugucucugugug


gcucgcagacccaugaagaagaaugcaggugggagaggaaggcgugacacccaagaagcaggcagagacaguccccaagacu


cuagcaagacuguuguggaugaugaggagauggggguuugcuuuuggaagauuaaguccuguaaaacuugucuaggccac


uccccaggaacuucaggaucaucugggagaugccccuuugaguggcugggcugugaggacagcaggccaguucuugccacc


cuggacagaaacacaucucaccuuucuggcucgaggaucugaacaccugucucuugccuacucggcuucuagucaggcauu


uugucaccuugucaagggucccagggacacaaagcucccuccucucacccacagcacucuggguccuacccccaaugcuuca


gggacauuuaaucaggucaaauugggaucaauggcuuugaugcagaaaagaacuguggacuaauagagauaggguuuaau


aaaaaaaauaucuuuuu












177
AW121930
uuuuuuuuuuuuuuuuucaacuuuaaagacuggauuugagguucagucugggucucuggg




ggggaccucugucaucacgccuauaaucaucccgagaguagucaucccuggagcuccacg




accgaucaucccgucugucauagcggucuucauagcgguccccaccuccucuguagucau




caucucuccgguacccacuuccaaaugcccuucugccacugccuauccuggagucauagc




cucggucauagucucugcugccucggucaucauagcgaucccggcccccauagcggucca




ugucucugcgugggccgucccgauauccgucccuauacccaucccgauaccggucugaau




cguaacgaucucgauacuugucuccaaagcuaucaucgccucuucuagguggguagucau




cacaacugucuguggugggacgggcccuccagucugugucuguuuug





178
AI852632
uuuuuuuuuuuuuuuuuggcccccaggcucugucucaaggaugggaauagaucaagccaa




acagugaaaaauaaggcaaaucguggcuucgggguuugagacuggcaccaauggcaaauc




agcagaggagaugcaaaugggguaacaaucacaguuagugggguaacaugagcaggcagg




aaacccuugagacaacacccaagguccacgucuucgcaugugcagggcacaacuccagca




gcaguuucugggcuuggaggcuuguuacucuuccuaccuuucccacccccuaaaagacac




caagauggagcccacgaagagauuacaucaagcucuucuggcuggg





179
U70475
Sequence below.










ucuaggacagccagggcuacacagagaaacccugucucaacuaaaacaaagcaaaccccccgaauauuguuuuuuauuugcg


gaugucuguuuauugagacgggguucauggcagacaugagugucucagugcauuugcuauccucucuucuaaaggggcgg


gggggggggugcgcuggagagguggcucagcaguuaagagcacugacuucucuuccagagguccugaguucaauucccag


caaccacaugguggcuuauaaccaucuauagugagaucugaugccuucuucuugccuguaggcagaccacuguauacauaa


uaaauaaaucuuaaaaggggggggaagguguggagcuaaaaguauggcaauaugcauaaguuuagcuauuucuguuguuu


ugcagucaucagugagccaaacuaauucgaauggguagcuagaucuuguugcuuuuagcgaauauauauugagugaaugg


aauugacagucuucuguauucucauucaguuuguuuguguucuuccccaucagugauaacauguagugaacuaacccgug


uggaccaucuuaaccauggcuucuccuuccuuuucuguuuuaaacauaggacauggauuugauugacauccuuuggaggc


aagacauagaucuuggaguaagucgagaaguguuugacuuuagucagcgacagaaggacuaugagcuggaaaaacagaaaa


aacucgaaaaggaaagacaagagcaacuccagaaggaacaggagaaggccuuuuucgcucaguuucaacuggaugaagaaac


aggagaauuccucccaauucagccggcccagcauauccagacagacaccaguggauccgccagcuacucccagguacacucg


ucguggugggagcuaaggaaaacucuagugagaaagcagacucucuggaguugaguucuuggucugccauuuacuguguc


uuuugugaggaggagaaguucucaaacuucgcuucuugauaaucaggacacagaucacagggaggacuuugugaguucag


aaacauccucuguggugaugaaacagcggcagaaauacuguugggaguaaaagaaguaggcauugcucauugugguaggca


gggcccugauuguauggguaacugacuuaacuguguuaaguaugauucccauuuuauauucccaugucuaaacaacuaaag


cauuugcccagaacacucagaaagaaaugaagggagguuauugccuagcacagagcccugguucagucccccacgcuguuc


guuaaaggggagggacuaauaauuugaacacaaucugguuugaaucuaugcaaaucgauuucugaaaugagaccauagguu


auuuuaugaacaagucuuauugcucguugugacccugugcuuagaacauuucauaaaugaugcucucugugccuuucccc


uuccuccagguugcccacauucccaaacaagaugccuuguacuuugaagacuguaugcagcuuuuggcagagacauuccca


uuuguagaugaccaugagguauaaaaauguuuguuuaacagcaaaacucccuuaucugauauuaguuccuuucauguguc


uccaauuaagagaagaaaagaaaauuuuagaaggaaaaaauugaucaaagaaauugucaaguaaacuguaugagagcuauau


aaugcuuaaaaauaagaccuguaugggcuggugagauggcucaguugguaagaguacccgacugcucuuccgaagguccag


aguucaaaucccagcaaccacaagguggcucacaacauccauaacaagaucugacucccucuucuggagugucugaagacag


cuacaguguacuuacauauaauaaauaaauaaaucuuuaaaaaaaaaaaauaaggccuguaaacuacaaguccauuuuacug


uauagcuggaaacaggaaucagaauaauuuucccuggaaacuggauauagauauauaaaauauuuugacuaguaaagaaca


acuauuaaucagcauuuggauuaaaaaaucuuaaucuguuguuugaagcauucugcuagauauuauggguacagauuaag


uccuaaugaauguuuuuauccauuuugaagucugccuuuaaauacauggagugaaauaaccuaggaguguauuaauaugg


agucacugggaggaggaaauguuucauuuuauaaaagcagccugagagcuguaggcccugcugcugucuguucuucaugc


cuuggcucucacucacaugaaucaaugucacgucaaucuuggcuuucuucacuugcauuucagucgcuugcccuggauauc


cccagccacgcugaaaguucagucuucacugccccucaucaggcccagucccucaauagcucucuggaggcagccaugacug


auuuaagcagcauagagcaggacauggagcaaguuuggcaggagcuauuuuccauucccgaauuacagguaagagagcucu


aggagugugcuguuuucugcgggcccuuuuaaauuagucauccuaguuauuuauuauuuacaugcuaccuccucaaagga


agaaauugaugguguauuuaaauuacucaugagagcuucccagacucacuuaacacacauaguuuuuagguaaucagacug


aauauuucuggauaaauucauucaaagacugaaagcuaauuuagaguucugacaaagauaaaauacuuaucuauugaaaaa


ugggaguugaaggaauuauugaaaagaacaccuuggauuuggggguagggaauugaucuaaaaugcacuuagccucugcu


cauacaaugugaccuucuuuccuagugucuuaauaccgaaaacaagcagcuggcugauacuaccgcuguucccagcccagaa


gccacacugacagaaauggacagcaauuaccauuuuuacucaucgaucuccucgcuggaaaaagaagugggcaacuguggu


ccacauuuccuucaugguuuugaggauucuuucagcagcauccucuccacugaugaugccagccagcugaccuccuuagac


ucaaaucccaccuuaaacacagauuuuggcgaugaauuuuauucugcuuucauagcagagcccagugacgguggcagcaug


ccuuccuccgcugccaucagucagucacucucugaacuccuggacgggacuauugaaggcugugaccugucacuguguaaa


gcuuucaacccgaagcacgcugaaggcacaauggaauucaaugacucugacucuggcauuucacugaacacaagucccagcc


gagcguccccagagcacuccguggagucuuccauuuacggagacccaccgccuggguucagugacucggaaauggaggagc


uagauagugccccuggaagugucaaacagaacggcccuaaagcacagccagcacauucuccuggagacacaguacagccucu


gucaccagcucaagggcacagugcuccuaugcgugaaucccaaugugaaaauacaacaaaaaaagaaguucccgugaguccu


ggucaucaaaaagccccauucacaaaagacaaacauucaagccgcuuagaggcucaucucacacgagaugagcuuagggcaa


aagcucuccauauuccauucccugucgaaaaaaucauuaaccucccuguugaugacuucaaugaaaugauguccaaggagca


auucaaugaagcucagcucgcauugauccgagauauacgcaggagagguaagaauaaagucgccgcccagaacuguaggaa


aaggaagcuggagaacauugucgagcuggagcaagacuugggccacuuaaaagacgagagagaaaaacuacucagagaaaag


ggagaaaacgacagaaaccuccaucuacugaaaaggcggcucagcaccuuguaucuugaagucuucagcauguuacgugau


gaggauggaaagccuuacucucccagugaauacucucugcagcaaaccagagauggcaauguguuccuuguucccaaaagc


aagaagccagauacaaagaaaaacuagguucgggaggauggagccuuuucugagcuaguguuuguuuuguacugcuaaaac


uuccuacugugaugugaaaugcagaaacacuuuauaaguaacuaugcagaauuauagccaaagcuaguauagcaauaauau


gaaacuuuacaaagcauuaaagucucaauguugaaucaguuucauuuuaacucucaaguuaauuucuuaggcaccauuugg


gagaguuucuguuuaaguguaaauacuacagaacuuauuuauacuauucucacuuguuacagucauagacuuauaugacau


cuggcuaaaagcaaacuauugaaaacuaaccagaccacuauacuuuuuuauauacuguaugaacaggaaaugacauuuuua


uauuaaauuguuuagcucauaaaaauuaaaaggagcuagcacuaauaaaagaauaucaugacuuaaacuacuuuggacuuu


uugaauuuauucacacuauuuuccauaggacaaucacucauuuaccacauuugguuauuuuacauuuucaaaauggguuu


gaaaauacagaggcauuuuauagccauguguggcaguccaugauuuuuuauucccgacauucaggaggcagaagcaggcag


aucccugggcuccaggacggccaaggcuacaugagagccugucucaagaaagacaaacccuuucuauacuaaacguuagcua


ggauugucaaggagaugguauauauccacaaugguaugccugcuguacaguacuguggcacagagaacaaaaccuguaacc


uccuguguucuuagaaguggcauucuaagaagggcuaggaaga












180
U09659
ggccagcaggacucuccuugcagcagcggcccgaguucagaguccggagcugcgguggug




gcggcgaaggcgagagucauggcuggacaagcuuuuaggaaguuucuuccgcucuuugac




agaguauugguugaaaggagugccgccgaaacuguaaccaaagguggcauuaugcuucca




gaaaagucucaaggaaaaguguugcaagcaacggucguggcuguggggucaggagggaaa




ggaaagaguggagagauugaaccugucagugugaaaguuggagauaaaguucuucuccca




gaauauggaggcaccaaaguaguucuagaugacaaggauuauuucuuauuuagagauagu




gacauucuuggaaaguaugucgacugaaaucacuguugaaauggugucacgugaagcugc




cauuccacugaugucugaacuauuucaucauguaaauaauuu





181
AW124785
uuuuuuuuuuuuuuuuucaggucucauuuucguuuauuugaaauucggugcucguguaag




uuuuuucucuuccccucaaauuuuauuucaguaaaaggagacuugggcgagguggauacc




ccacagccggauucuucccccccugccccccaggguggcuaaugcuaucuggggaagucg




ucauagggaagagaacuaugggugggcuccugccugaggccuccaaucucagcccagugg




acauaucacaggcagcuuaaaaaaaaaacccuaaaaaaaacaccccaaaacacacauuua




aauagguauucaagacagcuuuaaaaaaugcacccacucacaccccccucccuuuucuuu




uuggaaaaaaaaauaggaaaaaaaaaaaaaccaaaccgaauucucgcuuggccucua





182
AF071315
Sequence below.










auuuggcuccgaggccaagaauucggauccaaggcgggcgcggggaaaauggcggcggcagcugcggcgggggcgaaugg


gagcggaggcagcagcggcauggaaguggaugcagcaguccccagcgugauggccuccggagugacugggaguguuuccg


ucgcucuucauccccuugucauccuuaacaucucagaccauuggauccgcaugcgcucccaggaggggcggccuaugcagg


ugauuggggcucugaucgggaagcaggaggggcgaaauaucgaagugaugaacuccuuugagcugcugucccacaccgug


gaagagaagauuaucauugacaaagaauauuauuacaccaaggaggagcaguuuaaacagguuuucaaggagcuggaguuu


cuggguugguauaccacaggggggccaccugaccccucagacauccacguccauaagcaggugugugagauaauugagagu


ccgcucuuucugaaguugaacccuaugaccaagcacacagaucuuccugucagcguuuuugagucugucaucgauauaauc


aauggagaggccacaaugcuguuugcugagcucacuuacacucuggccacugaggaagcugaacggaucgguguagaccac


guggcccggaugacagcaacaggcaguggggagaacuccacuguggcugaacaccugauagcucagcauagugccaucaag


augcugcacagccgugugaagcucauuuuagaauaugucaaggccucugaagcaggagagguucccuucaaccaugagauc


cugcgggaggccuaugcccuaugucacugucucccaguucucagcacugacaaguucaagacagacuuuuaugaucaaugc


aaugacguggggcucauggccuaccucggcaccaucaccaaaacgugcaacacaaugaaccaguuugugaacaaguucaacg


uccucuacgaccgacaaggcauuggccggcgaaugcggggacuguuuuucugaugaugguucuggaagggauggugugug


gggcucagacagcuguuccauggaccugaguaccacauucccuuuagagaaacucauuaauaaaagagcagccccuuaaaaa


aaaaaaaaaaaaaaaaaaaaaaaaaaaa












183
D49733
Sequence below.










aaaacccaauguuugguuuuaaagccaaaaauauaagggaagugcauagguuuggguuuuguuuuuuguuuuuucccgag


guccuugaucuuugcccccaaauuugagggcauaaaguaaucccucaguuaccuaaaaacacagccauuccuuugccauucc


acucuccuggauuggccgcuucugugcgcgggggagaggugacucacuauuacuacugaggaaaggggagccaguggugg


aaguggggugagucacugaugggcagcagcuucagcccuccccccaacuuccuuggcucucuggggaugccugauccucuc


ccucacuuugcaccuacuuccccuggucccucaccacuacccuuugcccacccacucaaauucuuuggcucugcucuuuacu


ccagaaggccaaaggcaagcuuagaguugaguaggcaggaaccaacauugugaagccccaggccagaaagggguguucugc


agagugaggguuggcaugcuggcuccuccucaccauaccugcccccgccccuuuggguacaggauggcuccuuuaagagca


guggauccacccccuguagaggagggccuauuagagccucugccuggcugucagugacucaguguucgcgggaacgcugc


cucagccucaacaccagccaacccagaucccgaggugcgccagcgcccagcccagaucuccacgccugccaggagcgagcuu


cgccggcucgcugucccccugagcagccucuguccuucuguccaagucccgcgcccuucucgggaccccugcccagcgggc


agcacugucacccugccggccauggagaccccgucacagcggcgcgccacccgcaguggggcgcaggccagcucuaccccac


ugucgcccacucggaucacccggcugcaggagaaggaggaccugcaggagcucaaugaccgccuggccguguacaucgauc


gcgugcguucccuggagaccgagaacgcggggcugcgccuucgcaucacugagucugaagagguggucagccgagaggug


uccggcaucaaggcggccuacgaggccgagcugggggaugcccgcaagacccuugauucuguggccaaggagcgcgcccgc


cuccagcuagagcugagcaaagugcgugaggaguucaaggagcugaaggcucggugagugaggcccggccggccggcacca


gggaggcagcagucgccuguaacuggccaucuaguccccucccuccccggaacugccucccgcgggugacuggcagugcca


annnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


nnnnnnnnnnnnnnnnnnnnnnnnngcuaggccagauauagaaagcuuucuguauuuaauacacaguacaugcaucauuc


augucuacauaauuaagauaaaggaagcugcauuguuaaugggaaaaaaaauagggucugggaauguagugugccuagcau


uuacgaacuucgggguuuggguuugaucccagcaucucacaaaccacguguaaucccagcacuuggaagguagaggccgga


ggauccgaaguuuaaggucauucuugacuacuuagcaaauucggggcacccuaggauaccugagacccugucaugaauaaa


aauaaauaauaaauaaaccaauaugggucuagguugagcagcagcuugggcaggguagggccggaaguuagccagguagag


gguugcagucccaggaggacccuggcugggagcagcaccucaguccccugcccaaccacagggggccaccgggucuuuccg


gaacuccugagggcgcaaggccuugcucucucuggcccagccauggggaacgcggagggccggugaggcaggcggcaggc


gggcgggcggggcgcgggccgucauccccuccugcuccuuauuuuuagcccaguguagagucugggccgccugucccucc


cccaggacagggggaggaaauunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngaugccaacaauccuaauguaaugaugcccucuuc


ugacagcugcggggaccgcagagaggucccaucccagaugcacuccugaaaccugcuuuucuuuuucuagcaacaccaaga


aggagggggacuuguuggcugcgcaggcccggcucaaggaccucgaggcucuucucaacuccaaggaagcugcccugagca


cugcucucagugagaagcgcacauuggagggcgagcuccaugaccugcgggggcagguagccaagguaggccgcuguccu


gugaccccagugaccccaccugguccgacauaucauucggucccauuugccugcucaccuucacuucuccagucuagannn


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


nnnnnnnnnnnnnnnnnnnnnucuagauggggacagccaucaccucuccuuuggcauuuccugaacccccucccaccucu


ccaugaacuuggcuuucucccucucagcuugaggcggcccugggagaggcuaagaagcagcuucaggaugagaugcugag


gcgaguggaugcugagaacaggcuacagacgcugaaggaggagcuugacuuccagaagaacauuuacagcgagguaagcgu


cccgcuguacaggucuuucuuacuguggacagcugggaggggucaccuaauaaugccaggcuaagcgagggcugcccgug


ccuggccgguggaguuacgacuucuggucucagcuucuaaggaaccauugcgauguucuaaucuaagugucuccccuuaac


cuuucaggaacugcgugagaccaagcgccggcaugagacgcggcuuguggagaucgauaacgggaagcagcgagaguuuga


gagccggcuggcagaugcccugcaggagcugcgggcucagcaugaggaccagguggaacaguauaagaaggagcuagaaaa


gacauacuccgccaaggugcuggccucauccuguccucucccuggugcugcccuggggacgggugggugguggcaggggg


ccagggaugccuuccucaggcccccagcuccagguuccugcucucauaacugugugcucccugcagcuggauaaugccagg


cagucugcugagaggaacagcaaccucgugggggcugcccaugaggaacugcagcagucucgaauccgcauugacagccuc


ucggcccagcucagccagcuccaaaagcaggugacccucaguuuaccccucccaccuuggcucuggucuaagcagauacugc


agaagcccacugagaagggggugggggagggacuccaggaccacaugcuaugguucugaaucugaugccugucuggcuuu


ccagggcucuccuuuagcuagcccugauccucagagccucuauuuuacugugcaugaaggguuuuucauguuucuucugu


gccugccggagacugaaccagaggccucuugcuugguagauaggugcuuucucacugaguuacaaacccagccgcauuccc


uacuuggagauagagcuucccuuggacuggacauguagcucaguugguacagugcuugcuuauuauacacgauggccugg


cuucuauccccaggaccnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn


nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnucuagagagagccuacagauccugagugucccucugccug


ccccugugccccucccucuucaucgacaucagcccuugggagcucaucagacccuuugucuuccccgccccaguuggcagcc


aaggaggcaaagcugcgugaccuggaggacucgcuggcccgugagcgcgauaccagccggcgccugcuggcugagaaagag


cgagagauggcggagaugcgggcgaggaugcagcagcagcuggacgaguaccaggagcugcuggacaucaagcuggcccug


gacauggagauccaugccuaucgaaagcugcuggagggcgaggaggagaggugaacuaggaggggucuacagaacuuguc


aggggccucuggccgcaacuaccaugacuaaccccgcaccgugucuccaccuuccccaggcugcgccugucccccagcccua


ccucgcagcgcagccguggccgcgccuccucccacucaucccagucucaggguggaggcagcgucaccaaaaagcgcaagcu


ggagucuuccgagagccggagcagcuucucgcagcaugcucgcacuagcgggcguguggcgguagaggaagucgaugaag


agggaaaguucgugcggcugcgcaacaaguccaacgaggugggccugugaaccaggguggucuuuucaguggcugggagu


ucuugguucucguggagcaucugucucccuaucugagaauuuggagugugugguaguccugucaucuuuaaauuguugg


gaagaugcaugauauagggaugggugacccuugagccaauagucuagguuugaugccagagguagugguggaagccuguc


uuucuuuucuuuuucuuuuucuuuuucuuuuucuuuuucucuuucuucucucuuuuuuuuuuuuccgauggggucuug


cccagguuggcuuugaucucccuaguuaagcuguuccccugccucagccuccauaguagcuggaacugcaggngcacacug


gcgnccagccuaccuaagcuccugagugagauaauccaagagucgguugaacucccuguccuccuuccuccuuccuccuuc


cuccacccuacuucaggaccaguccaugggcaacuggcagaucaggcgucagaauggugacgauccuuugaugaccuaucg


cuucccaccgaaguucacccuaaaggcugggcagguggugacggugaguggaagggcacuugggacucuggcuggagugg


agaaguuggccucaggacaggagcauuaaaaauaagcacaucucuuaaaccaucuuuucccagaucugggcuucaggagcu


ggggccacccauagccccccuacugacuugguguggaaggcgcagaacaccuggggcugugggagcagccuucgcaccgcu


cucaucaacuccacuggagaagugaguauguugcagccgguagcuugcuggacaaggcucccccgggugaccauaauggga


acuagcuaccuccaacccaagggaaccugccuuggguuuaggaucgcuuuccugagcccaagucccacccaguaagcaagcc


agaagucuccccaguagaauaauggguggaagucagccagugaguguuaauagcagacuccagcuuacagagcaccgagcu


cucaguuguguccuuuuugcgcgugcgugcgcgcgugugcacaugugcauguguuuauccuuaguccccagcaucagagg


uuggacaagguuguauaaaggcccgggacaguucuaagugguuacuauggguagacaggcugcacagcccucacccccuga


cucuugggccugggcuuauguccccacaggaaguggccaugcgcaagcuggugcgcucacugaccaugguugaggacaau


gaggaugacgacgaggauggagaagagcuccuccaucaccaccgugugaguggcagccgccgcugaggcccagcccacaag


gguagcccugccagccuagggcagcucucccaccuccaugccaaagucuuuucauuaaagaauguuuuggaaugccacuug


cugcccuggccuuucuucucucuccucccucuaccuugaacagggaacccaggugucugguaaggaagggaguggggacu


ugcugaugccauggauacuccacgguggcaguggacaggguucuggauuuguguccugggaaggggcugggaggacagag


guggccccagcccugccucucuuccucacucccauugcaugcacacuucucuccucucuccuuccacccuauugcaugcuuc


uccucagauuucccugcaacaauguucucuuuccuuccuguccccucacaaauuaagucucuccaucuuugcucuuccucu


ugauugccccauaagugucuaagauucaggagagaguuaaagccacagcucuuuauuucgaaggcuuccuggcuauuuccc


ccaucaugcccuuccucccagccacaggucucccaaguccccaucacuugguugucuggguacagacagaggucaccuuccu


gcccaauggccaggaagcuccaagagcccacagccuaggugccgguccuaagaagucagucccaaacucgcugucccuccug


agccuugucucccuucccaggguucccacugcagcggcucgggggaccccgcugaguacaaccugcgcucacgcaccgugc


ugugcgggacgugugggcagccugcugacaaggcugccgguggagcgggagcccaggugggcggauccaucuccucuggc


ucuucugccuccagugucacagucacucgaagcuuccgcaguguggggggcaguggggguggcagcuucggggacaaccu


agucacccgcuccuaccuccugggcaacuccaguccccggagccaggugagucaucucugcccuacagcaggacacugcuca


cugagcagcagggcagggcagcccaagggaguggggucccccuccuugcagucccucuugcauccugccccuccugucuga


accccagacucgaggucagggcaaggcccagagugugaggguuggggagacaaccccuuuggggucagggagggagagga


agggccagccacugcugcucacaccucugccuucucuucucucuuagagcucccagaacugcagcaucauguaaucuggga


ccugccaggcagggcugggggcagaggccaccugcuccccccucaccacaugccaccuccugucugcuccuuaggagagca


ggccugaagccaaagaaaaauuuauccccugccuuugguuuuuuuuuuucuucuauuuuuuuuucuuuuucuaagagaag


uuauuuucuacagugguuuuauacugaaggaaaaacucaagcaaaaaaaaaaaucuuuaucucaauccuaaguccuuccccu


uucuuuccuuguaucugccuuaaaaccaaagggcuucucuaggagcccagggaaaggacugcuuuuuauagagucuagau


uuuuguccugcugccuuggcuuuacccucaucccaggacccugugacaauggugccugagaggcaggcauggaguucucu


ucaccagccuccuccaacagcuggcccacugccacgccagcugcagagaaauggggcgcagagaggaugacugagaagguca


agccccuccccggcacuacacgaggccgaggcuccucugccugccuuaccuucuuccugcccuucccuagccuggggcgag


uggauucccagaggcaaaucugccgugcuugcuuuuucuauauuuuauuuagacaagagaugggaaugacggggaaggag


aagggaagaucaguuugagccuaccuuuucccagcuucugagccuggugggcucugucucaaugauggagggcaauguca


agugggauacagggaagagugggggacgaaggcucccagagauggggagaaccugcuggggcuggugagaagucuagagg


ugcggcgauugguggcuacagcaaacacuaaggaacccuucaccccauuucccaucugcaccucugcucuccccuccaaauc


aauacacuaguuguuuccaucccagaugcuguggugucucuuuguugggugugauguguguuuucaggggcagacacau


gcacacagaggugccacacauucacuauauauucacuacccagcuauaaagguguguaugagggagacuucuagaaagguc


agcauauguggggugagcgagggguguccuuccuaucccucauccauccagcaccuuuuaaaaggggccagcaauccacau


gugcaucagacacaggagcacagagagacggaggguagaguagggcagaguagcagagcuuccuugcugcccuguagucgc


aggcucuugaucgugugaucgcu












184
X80899
Sequence below.










gcggugcgaagcgggccuccgccaacauguacuacaaguuuagcaguuucacgcagaaguuggcuggagcuugggcuucg


gaagccuacaccccgcagggguuaaagccaguuuccacagaagcaccaccuaucauauuugccacaccaaccaaacugaccuc


cagugugacagcauaugauuauucugggaagaacaaaguuccagagcugcagaaguuuuuccagaaggcugaugguuucca


ccugaaacgaggccuuccagaccaaaugcuuuaccggaccaccauggcucugacacugggagggaccaucuacugccugauc


gcccucuacauggccucgcagcccagaaacaaaugagcuugccuguggaggacugguucacuuuguggcacaaacccuuug


aauccucacguuucauguuuuccacuuggauagucuacuuaacauuuugcaaacaaaggaaaagauaagaauacauuguuu


ugauuuguuuauggugugcagauggccugucagaugucagagcugguuugacaguuaaaacuauuguuuaaggaaauguc


acugagccaucacugagcugugcuucugcuccugauuucccuggaguucugcaggaaaguugcucuccagcucauucgug


gccagccgugcucagggccucgggacucaggcggugucugagcgggaagcgaacgcggaagccuuuuggaguguaggugu


gauugaggaaggaaaacaaaagccagcggacagguggugaagugagggcugaguuagccacccuagggauucguccgccuu


gcagaaaacauugagaggaaugauagcaaccugccucuauuugugggcaguugguuucaaaggguugugugucucgccca


gaaccuagggaaauggguguuuguuccaucgugggaggagcaccugucagugcugcacauuagacagcugugucaggacu


ucuccuuuaauaaugcuguggcuuuacguuaugauugaccggacugcggaauaaacacuggaaucaaaaaaaaaaaaaaaaa


aaa












185
D83203
Sequence below.










cugagacagaacgaaacguccgcagauaacuacccguucuggcucuuguuaguucuauguguauggauaaugucuuggga


gguuuugaaaugccacaagccuugcuggcccagggugcagcugccucugccguucagaccucagauuauaaggacagaaca


cagcacggaaguggggggaucagaaccaugggagauccaggacgaaggguccugugcgcaggugcggcaccgaauccuaua


uuugacauugaagcugucgucagcccaacuaguguguuauuaacauggaagcacaaugacucaggcgcuucagaauguaga


auagagaauaagauggagagcaaucugacguuuccuguuaaaaaccagacaucauguaacauuacaggcuuaagcccaggu


acuucguauacauucuccaucaucucuguaacaaccaaugagaccuugaacaaaacuaucacaacagagcccuggccagugu


cugaucuccaugucaccucugugggugugacacaggcucgucucaccuggagcaaugcaaauggcacugccuccuaccgga


ugcugauugaagaguugaccacacauuccucagucaauauuucaggucugaagccggggaccaauaauacguucgcuuucc


cagaaucaaaugagacacaggcugacuuugcaguugcagaggaggucccggaugccaaugguaccaagagaaucccaguga


ccaaccuaucccaaccacacaagaauucucuugccucuguggacccacccucuggccaggaucccucccucacagagaucuu


gcuuacugaccuaaagccugauacucaguacaaugccaccaucuauucucaagcagcaaauggcacugaaggacagcccagg


aacaaaguguuuaaaacaaauuccacccagguuucugacguccgagcuaugaacaucagugccucaagcaugacccugaccu


ggaaaagcaauuacgaugggucccguacuucaauugucuacaaaauacacguggcugggggggaccacuccgucaaccaaa


cugucaauaagacugaggccaucauccucggacucagcuccagcaccuuguacaacaucacaguucauccuuuccuggguca


gacggagggcacaccaggcuuccuccaaguguacacuucccccgaucaggucucugacuuccgagugacaaaugucagcaca


agggcaauugguuuggcuuggaggagcaaugacuccaaguccuucgagauuuucaucaagcaggacggaggugagaagca


ucgaaaugcuucgacgggaaaccagagcuauaugguugaagauuuaaagccuggaaccaguuaccauuuugagauaauucc


acgaggaccagacgggacagaagggcuguccaguacagugaaugggagcacugaccccagugccgugacugacauccgggu


ggucaacauuagcaccacugaaaugcaguuggaguggcagaauacggacgaugccucuggauacacuuaccauuuaguucu


agagucuaaaaguggcuccaucaucaggaccaacaguucucagaaguggaucacaguagggagccucaccccaggcaccuua


uacaaugucacaaucuuuccagaaguggaccagauccagggaaucuccaacuccauuacccaguacacacggcccagcagug


ugucccacauugaaguaaacaccaccaccaccacggcagccauccgauggaagaacgaggacacagccucugcuuccuaugc


cuacuccguccuuaucuugaagacuggagauggcagcaauguaaccagcaacuucacaaaagacccuucuauucuaaucccu


gaguuaaucccuggcgucucuuacacagugaagauccuuacacaaguuggggaugguacaacaucacugguaccugguugg


aagcuguucuguacggaaccugaaucagugaccuccuuccacugugaaguggucccuaaggagccagcauugguucucaag


ugggccugccccuuuggcauguacacaggcuucgagcugggggucaggagugauuccugggacaauaugacacgccuaga


gaacugcacaucggaugaugacacagagugcaggacggaagucgccuauuugaauuuuucuaccucguacaacaucagcau


cgccaccuugucaugugggaagauggcgcuucccgcccagaacaucugcaccacuggcaucacagacccaccuacuccggau


ggauccccuaauauuacaucggucagucacaauucaguaaagguuaaguucagcggguuugaagccagccacggaccuauc


aaagccuaugcugucauccucaccaccggggaagcugcccaaccuucugcagauguuuugaaguacacguaugaggauuuc


aaaaggggagccucggauacuuaugucacauaccucauaagaauagaagagaagggacagucucagggcuugucugaaguc


uugaacuaugaaauugauguggggaaccaauccacuacccucggcuacuacaacgggaggcuggagccucugggcuccuac


cgggauuguguugcuggcuuuaccaauauuaccuacaaccuucagaaugacggccucaucaauggggaugagagcuaugu


gucuuucaguccauauucagaggccguguucuugccccaggauccaggugucaucugcggagcaguguuuggauguaucu


uuggugcccuggccaucacagcugugggaggcuucaucuucuggagaaagaaaaggacagaugccaagaauaaugaagugu


ccuuuucucaaauuaaaccuaaaaaauccaaguuaauccgaguggagaauuuugaggccuacuuuaagaaacagcaagcuga


cucuaacuguggguuugcagaggaauaugaggaccugaagcugauugggauaaguuuaccuaaauacacagcugagauagc


cgagaacagagggaagaaccgcuacaacaauguucugcccuaugauauuucucgagucaaacuuucaguccagacccauucg


acagaugacuacaucaaugccaacuauaugccuggcuaccauuccaagaaagauuucauugccacacaaggaccuuuaccca


acacuuugaaagauuucuggcguaugguuugggagaaaaacguauaugccauuguuauguugaccaaaugcguggagcag


ggaaggaccaaaugugaggaguacuggccuuccaagcaggcucaggacuacggggacauaacuguggcgaugacaucagaa


gucguucuuccagaauggaccaucagagauuuuguggugaaaaauaugcagaauagcgagagccauccucugcggcaguuc


cauuucaccuccuggccugaccacgguguuccugacaccacugaccugcucaucaacuuucgguaccugguccgggauuac


augaagcagauaccccccgagucaccaauucuggugcauugcagugcugggguuggaaggacgggcacuuucaucgccauc


gaucgccugaucuaucagauagagaaugagaacaccguggacguguaugggauugucuaugaccuucggaugcacaggccu


cugauggugcagacagaggaccaguauguuuuccucaaucaguguguuuuggauauuaucagagcccagaaagacucaaaa


guugaucucaucuaucagaacacaacggcaaugacaaucuaugaaaaccucgagccaaguuccuugaaugugacuauguug


cuucauccacagcugaacgauuuuggauguuggguucuagguccuggcuguugcuggucugcuaggauccagggccuugu


ugacaucugggaagauguaaauugucccgcugaaggccgcaguuuuagauguggccacuagauggagccagagcacuggu


augaaggagcaccagggccguguaaggcaaaagaggacccagaaaaagaaacuuaacuuguucacuccugagaaaccugcaa


gucaacaagccaaggaagugccuuugcaugcauuugguagccuuuccaaucccgcuuauuacauaauauguucauguucau


ggcaaaaaaaaaaaaaauaaaauaaaauaaauaaaaaaggaaaacaaaauaaaaaaaaucuuagaacauu












186
Z20410
gcccccucaagggcauccugggcuacacugagcaccagguggucuccucugacuucaac




a




gcgacacccacuccuccaccugacgcuggggcuggcauugcccucaacgaccacuuugu




c




aagcucauuuccugguaugacaacgaauuugcuacagcaacaggguguggaccucaugg




cccacauggccuccaagguaagccccuggaccaccagccccagcaaggcacaagaggaag




g




agagacccu





187
AI839906
uuuuuuuuuuuuuuuuucauauuaaacuuguaguuuuauucagguuugauuuuuaac




aaaugugucagggagagagcccacaggaaaggguaaagcccgugggggcaaggccuucc




cagaugccugaggagggaucguguccccucccccccuccucuucucaccaccccuacagg




gguuugggaagagacacaggcagggaaggggcugguccccagucuguacaguggugcu




ugggggugaaggacuauggagaacaggggaccagaucggggaugaguaggauaaaggg




cacaagaccauuuaccagaauccagcuuucugauuccaaauugaauuaaaaagaaaaaaa




ggagaggggaaccuaaaccacaagcaguacccaacucccuuucccccaucagggcugc





188
AI843448
uuuuuuuuuuuuuuuuuagggaagaggcugaugccagauaaguuuuuauuauauuaa




aaaaaaaaaaaaaaccagugcaacuggaaaucagggugagucgcuggaggugagugaga




gucggaaggcccuccacaccucagugguggcaggaucuggacccguagccuaagccugg




ucugauccagccgagaugcuggaaagcagagcacacgguggugcccaucagggcaaaga




gggcaagagagcccacggcuccuccauaccgcuugcuagggucuccuguguaguagcca




uaugcguaaaggacucgcccaauaauccaggccaggcccaggccagaagcuaugcgcgg




gugguaaacaccucccaccguuaggaaaaa





189
AW125336
cggccgcgugaguuuugacugagcuucugcangaaguucanaugcaacuccauacauca




guucauuuucuagcauuaccacuggguuauuaucacgaauggccgauuuaauaagucc




uuuugcauccucggaauuccaggggcugaccacuuuuaaaccugggcagugcccauacc




augcagcaaagcauugcgagugcugagcagcuacaccugcugaggcgccauugggcccc




cugaauacuaugggcaca





190
AW123802
uuuuuuuuuuuuuuuuugaagggccauuggaguuuauuuacagacaaccuuagguga




ggccuuuuccucuaggaucuacaugcuuuugaaguuacuugguuucaggcuucuuguc




uccagcuucgagcuugagacucucaggaggcuggcgauaggcagggaaagccucccagg




ggcuguucaggucaaacuugcggaauucuugugccagcuccacugguucagccacuacc




cgcuuuaccucaucgucguaacgaagcucaacauagccagugaggggaaagucuuuccg




gaaaggaugucccucgaagccauaaucugucaggauccuucuuaaaucagggugguuaa




aaaaaaaaaaaaaaaaaaaa





191
AI835771
uuuuuuuuuuuuuuuuuggggggcagcgaacuuuauugaugguauucaaaaaaauag




ggagggcucccuaggcccccccuguuauuaugggggucugggauggaaauuuugaggg




aaaugcucaauuuugggggcccauuugggaaaaggccccccuugcccaauguccuugcu




ggggugggugguccaagguuucuuacuccuuggaggccauuuuggccaagagguccac




cacccuguugcuguagccguauucauugucaaaccaagaaaugagcuugacaaauuugu




cauugaaaaaaaugccaaccccggaaucaaagg





192
X53584
Sequence below.










gcuccucaucucacucgggccuaugccaaagauguaaaauuuggugcggaugcucgagccuuaaugcuucaagguguagac


cuuuuagccgaugcuguagcuguuacaauggggccaaagggaagaacagugauuauugaacagaguuggggaagucccaaa


guaacaaaagauggggucacuguugcaaagucaauugauuuaaaggauaaauacaaaaauaucggagcuaagcuuguucag


gauguugccaauaacacaaaugaagaggcuggggauggcaccaccacugccacuguucuggcacggucuauugccaaggag


ggcuuugagaagaucagcaaaggggcuaauccaguggaaauccggagaggugugauguuggcuguggaugcuguaauugc


ugaacuuaagaaacagucuaaaccugugacaaccccugaagaaauugcucagguugcuacaauuucugcaaacggagacaaa


gacauugggaacaucauuucugaugcaaugaagaagguuggaagaaagggugucaucacagugaaggauggaaaaacccug


aaugaugagcuagaaauuauugaaggcaugaaguuugauagaggauauauuuccccauauuuuauuaacacaucaaaaggu


caaaaaugugaauuccaagaugccuauguuuuguugagugaaaagaaauuuuccaguguucaguccauugucccugcucu


ugaaauugcuaaugcucaucggaagccauuggucauaaucgccgaagauguugacggagaagcucuaagcacgcugguuuu


gaacaggcuaaaaguuggucuucagguuguagcagucaaagcuccaggguuuggggacaacaggaagaaccagcuuaaaga


uauggcuaucgcuacugguggugcgguguuuggagaagaggguuugaaucuaaaucuugaagauguucaagcucaugauu


uagggaaaguuggagaggucaucgucaccaaagaugaugccaugcuuuugaaaggaaaaggugacaaagcucacauugaaa


aacguauucaagaaaucacugagcagcuagacaucacaacuagugaauaugaaaaagaaaagcugaacgagcgacuugcuaa


acuuucagauggaguagcuguguugaagguuggaggaacaagugauguugaagugaaugagaagaaagacagaguuacug


augcucucaaugcuacaagagcagcuguugaagaaggcauuguucuaggagggggcugcgcucugcuucggugcauccca


gccuuggauucauuaaagccugcuaaugaagaccagaaaauagguauagaaauuauuaaaagagcacuuaaaauuccugcaa


ugacgauugcuaagaaugcagguguugaaggaucuuugauaguugagaaaauucugcagaguuccucagaaguugguuau


gacgccaugcuuggagauuuugugaacaugguggaaaaagggaucauugauccaacaaagguugugagaacugccuuacu


ggaugcugcugggguggccuccuugcuaacuacagccgaagcuguagugacagaaauuccuaaagaagagaaggacccugg


aaugggugcaauggguggcaugggaggggguaugggaggcggcauguucuaacuccuagaguagugcuuugcccuuauca


augaacugugacaggaagcucaaggcagguuccucaccaauaacuucagagaagucaccuggagaaaaugacugaagagaag


gcuggcugaccacuguaaucaucaguuacugguuuccuuugacgauauauaaugguuuacugcugucauuguccaugccu


acagauaauuuauuuuguauuuuugaauaaagaacauuuguacauuccugaugcugguugcaagagccauauaccagugu


ccugcuuucaacuuaaaucacugaggcaucucuacucuucugugagucaucaggacuguagcgcugugucaacaaaacaua


gagaguucagaagacagccuuucuguggaagggugggaaugauuguguacaaaguagagaaguauccaauuaugugacaa


ccuuuguguaa












193
M32599











acagccgcaucuucuugugcagugccagccucgucccguagacaaaauggugaaggucggugugaacggauuuggccgua


uugggcgccuggucaccagggcugccauuugcaguggcaaaguggagauuguugccaucaacgaccccuucauugaccuca


acuacauggucuacauguuccaguaugacuccacucacggcaaauucaacggcacagucaaggccgagaaugggaagcuug


ucaucaacgggaagcccaucaccaucuuccaggagcgagaccccacuaacaucaaauggggugaggccggugcugaguaug


ucguggagucuacuggugucuucaccaccauggagaaggccggggcccacuugaaggguggagccaaacgggucaucaucu


ccgccccuucugccgaugcccccauguuugugaugggugugaaccacgagaaauaugacaacucacucaagauugucagca


augcauccugcaccaccaacugcuuagccccccuggccaaggucauccaugacaacuuuggcauuguggaagggcucauga


ccacaguccaugccaucacugccacccagaagacuguggauggccccucuggaaagcuguggcgugauggccguggggcug


cccagaacaucaucccugcauccacuggugcugccaaggcugugggcaaggucaucccagagcugaacgggaagcucacug


gcauggccuuccguguuccuacccccaauguguccgucguggaucugacgugccgccuggagaaaccugccaaguaugaug


acaucaagaagguggugaagcaggcaucugagggcccacugaagggcaucuugggcuacacugaggaccagguugucuccu


gcgacuucaacagcaacucccacucuuccaccuucgaugccggggcuggcauugcucucaaugacaacuuugucaagcuca


uuuccugguaugacaaugaauacggcuacagcaacagggugguggaccucauggccuacauggccuccaaggaguaagaaa


cccuggaccacccaccccagcaaggacacugagcaagagaggcccuaucccaacucggcccccaacacugagcaucucccuca


caauuuccaucccagacccccauaauaacaggaggggccuagggagcccucccuacucucuugaauaccaucaauaaaguuc


gcugcacccac












194
AF035644
agaagcuuccuaaggaacaagcaaguugaauagagaaaauagugaucaauaauaggcauu




uuaguggucuuuuuaauguuuucugcugcggaacauuucaagauuuauugauuuccucc




uccccccauuuuuuucccaccacacucacacacgcacgcucacacuuuuuauuugccauaa




ugaaccguccagccccuguggagaucucuuaugagaacaugcguuuucugauaacucaca




accccaccaaugcgacucucaacaaguucacagaggaacuuaagaaguacggagugacaa




cuuugguucgaguuugugaugcuacauaugauaaagcuccaguugaaaaagaaggaaucc




acguucuagauuggccguuugaugauggagcuccacccccuaaucagauaguagaugauu




ggcuaaaccuguuaaaaaccaaauuucgugaagagccaggcuguuguguugcagugcauu




guguugcaggauugggaagggcuccugugcuaguugcgcuugcauugauugaaugcgga




a




ugaaguaugaagaugcuguucaauuuauaagacaaaaaagaagaggagcauucaauucca




aacagcugcuuuacuuggagaaguaccgaccuaagaugcgguuacgcuucagagauacca




augggcacugcuguguucaguagaaguagaagcaggcuggcuggaucguggcauuagag




g




gaa





195
Y00629
Sequence below.










auucagguuccucacagacccagggggugaggauguugcuuuuugcccacuugcuucagcugcuggucagcgccacaguc


ccgacccagaguaguaagugaggggaggggugaggggagggguugggagcgaaaaagacucugugaggaaaagcgggagg


guggugguggcggaggugcagcaccccaaguuccgccgcccuguccuagucccucccccgccuuuaccugggaccuugagc


cugggggaggucggggucucaccgcgcgccgcccccaggcccacacucgcugcgguauuucaccaccgccgugucccggcc


cggccucggggagccccgguucaucauugucggcuacguggacgacacgcaguucgugcgcuucgacagcgacgcggaaaa


uccgaggauggagccucgggcgcgguggauugagcaggaggggccggaguauugggagcgggagacuuggaaagccaggg


acauggggaggaacuucagaguaaaccugaggacccugcucggcuacuacaaucagaguaacgacggugagugcggcuggg


aucacagcuaugaucacuccauguccccugagacgggccugggucaucuugacccgcugagacaaaguuucauccaaacgcc


uacccagaaccucagacaaaaaagcccccgcagaguucugcuuagguuugggguuguacuuuuguuucucuuuuguuuug


agauaucuacuaacauugggcaaaguggccacagguggcgcucaucagcguaucccuuccagaaucucacacgcugcagug


gauguacggcugcgacguggggcccgaugggcgccugcuccgcggguauugucaggaggccuacgauggccaggauuaca


ucucccugaacgaggaccugcguuccuggaccgcgaaugacauagccucacagaucucuaagcacaagucagaggcagucga


ugaggcccaccaacagagggcauaccugcaagguccuugcguggaguggcuccauagauaccuacggcugggaaaugagac


acugcagcgcucaggugcccuggagagcucuccucacuuuuccucugcgguuugggggaaauccuugagguauaaccuca


ggggcagaacgcuguucagcgggcacagcgcggaggaggagggagagggacucccaaaacugcuuuuccccuguagggau


ucuaauccuuaacaaaagcagaucaggcucgacaauggcccuggacccauggggggagggggcucuuucucaggccucccu


ccuugcccuacucagugucucuauagucagacuccagcuuuucucaaucucuuggcccucauccagcucaggaccagaagc


ccuucccaugagucugcagagaccuggagccuccuguccauguuguccugcucacauccuaaggcaucccuaagagcagau


ccucccaggugcaggugcucuagcuggugucuagaugauggacaccauaaucccaccgcaguccuccuguccaccccagga


cggucacaugaacacugcugaguccccagaagaaagcaagaugccucauccuuucaacucucucccucagacccuccaaagg


cacaugugacccaucacccuagaucugaagaugaagucacccugaggugcugggcccugggcuucuacccugcugacauca


cccugaccuggcaguugaauggggaggagcugacccaggacauggagcuuguggagaccaggccugcaggggauggaacc


uuccagaagugggcagcugucguggugccucuugggaaggagcaguauuacacaugccauguguaccaugaggggcugcc


ugagccccucacccugagaugggguaaggagggugugggugcugaacuggggucagggaaagcuggagccuucugcagac


ccugaguuggucauggcucagagcugggaucauaacccucaccuucauuuccuguaccuguccuucccagagccuccucca


uccacugucuccaacaugguaaucauagcuguucugguuguccuuggagcugugaucauccuuggagcugugguggcuuu


ugugaugaagaggaggagacacauagguaggaaagggcagggucugaguuuucucucagccuccuuuugcagugugcucu


gcuccuuaaugggaaacauagccacacccacauugcugcagucuccaacugggucagcugucaguuccgggaacucccuag


ggcugguguuucucuggucucucauggcuuuucuucucacagguguaaaaggaugcuaugcucauguucuagguaagugc


gagagaggggcaggggacacccuugucccugaggcucucaggauggagcugggauuuguuccagcccauaaucuccucuu


gccacauccucucugucuccucugugugccuuguuaucucuucuacugcaggcagcaagagcuuccagaccucugacuggc


cucagaaggcaugaaaaucccugggggggcuggugagauggcucaguggguaagagcacugacugcucuucugaaggucc


agaguucaaaucccagcaaccacaugguggcucacaaccauccguaacgagaucugacucccucuucuggagugucugaaga


cagcuacaauguacuuacauauaauaaa












196
AW125380
uuuuuuuuuuuguucccuugaaagccagauguuccaaaaaguagccugcuccauuguucu




ucucagucucauagcgacugccagcgucaauccacacucccaccgugcagguagcaugcg




aggacugcuccgaggccacacgcagcccguuguccaagaugcugaccugggucuccggca




cgcucuggagggccugggcgaagguugcgguaccccgcaaggcagguaaccucagcaggg




ccggcgagcggcgggugcgccucgugccg





197
U68564
Sequence below.










ggugcuuaauguuuugaccuguagagguccucacuuuucgucauggcgcugaagguggcgauagcugcuggcggugcug


caaaggcaaugcucaagccaacucuccucugccguccuugggagguucuggcugcccauguggccccccgaaggagcauuu


ccucacaacaaacaauuccuccaucugcuaaguauggugggcggcauacagugacuaugaucccaggggauggcaucggcc


cagagcucauguugcauguuaagucuguauucaggcaugcaugugugccgguggacuuugaagaggugcauguaagcucc


aacgcugaugaggaggacauccgcaaugccaucauggccauccgccggaaccguguggcccugaagggcaacauugaaacaa


aucauaaccugccaccaucccacaaaucucgaaacaacauccuucgcaccagccuagaccucuaugccaacgucauccacugu


aagagccugccaggaguggugacccggcacaaggacauagacauccucauuguacgggaaaacacagaaggcgaguacagca


gccuggagcaugagagcguagcaggagugguggagagcuugaagauuaucaccaaagccaagucccugcgcauugcugaau


augcuuucaagcuggcccaggagagugggcguaagaaagugacggcugugcacaaggccaacaucaugaaacugggugaug


gacucuuccuccagugcugcagggaaguagcagcccacuacccucagaucaccuuugacagcaugauuguagacaacacaac


aaugcagcugguaucccggccucagcaguuugaugucauggugaugccuaaucucuaugguaacauugucaacaacgucug


ugcagggcuaguuggaggcccaggccuuguggcuggggccaacuauggccauguguaugcaguauucgagacagcuacaa


ggaacacaggcaaaaguauugccaauaagaacauugcuaacccgacugccacacugcuagcaagcugcaugaugcuagacca


ccucaagcuccacuccuaugccacuuccauccgcaaagcugucuuagcauccauggacaaugaaaauaugcauaccccagau


auuggaggccagggcaccacaucccaagccauccaggacaucauucgucauauccgcaucauuaauggacgggcuguggag


gcuuagcuaucccuacaguuuugcucagcuugucuguaggacucucuucucacuuuagcacuccagcuagcuugggggac


aggacccagaauaaagccacuucuguuccagaaaaaa












198
AW125346
uuuuuuuuuuuuuuuuuguucuuaauagaaaacuuuauuuucacugauaaugucacugua




acauaauuucauagcagaccugugcaaaagaucccacaucaccaaugucuccaagagauu




ucacacacuucugggcaggacgcacagcucugcccccacccccguguugacagucaacau




uuuacccccgcuaugaguacagaaaggcgaggcaucauaacgaagccgccugaaggcagc




gugagcugaagucggacgcuugccaccucugaaugaauggucaccacagcaacagcacau




gguugccucagugugcucagggugggucuuugaaaaaacgucccacuauguaaauaugcu




gcacuuaucccuucaacauugu





199
X61232
See above (same Accession Number).





200
D20333
gauccuguauauguguguuuugggggagcuaugauaaguuuuauggcaaacgguugguau




uguuaacuuuuuauugucaucaaaaguucauaaaaguccuauuaauccccauauucunnn




ncugcccuuaacucugguauacaccaaaaagaaaucuuuacuuuccuuguuuuaucauua




uaaaaauaaaguauuuugcuaguauggaaa





201
AB025218
aguccgcgucccggcgucggcccgucccgcaccauggugacgcucgccgagcugcuggcg




cugcuggccgcgcugcuggccacggccucgggcuacuuugucagcaucgacgcgcacgcc




gaggagugcuucuucgagcgggucaccuccggcaccaagaugggccucaucuucgaggug




gcggagggcggcuuccuggacaucgacguggagaucacaggaccagauaauaaaggaauc




uauaaaggagaccgggaguccagcgggaaguacacauuugcagcccacauggaugggaca




uacaaguucugcuuuagcaauaggauguccacuaugacuccaaagauaguaauguucacc




auugacauuggggaggcucccaaaggacaagacauggagacagaagcucaucagaacaag




cuagaagaaaugauuaaugagcuggcaguggcaaugacagccguaaagcacgaacaggag




uacauggaaguccgggagagaauacacagagccaucaaugacaacacaaacagcagagug




guccuuugguccuucuucgaagcucuuguucuaguugccaugacauugggacagaucuac




uaccugaagagauuuuuugaaguccggaggguuguuuaaaaggccuuuuccuguugaucc




caaauucaugauuuacu





202
U84411
Sequence below.










gcauuggcucugggcugcggccggcucggcgacgcuccucgggcagcucacugcauggucgucuggugcccccgccgccu


gcauccccgccgccgccccgcgacgcccaccgccgccugcccugccgccgccgccugcgccgccucgggaccggcuguauga


uuaggccacaaucuucaaugaguagacauauuccucaguucugugguguucucggucacacauuuauggaguuucugaag


ggcaguggagauuacugccaggcacagcacgaccucuaugcagacaagugaacuguagaaauucauuacuacuccaccaaga


aacccccauaagaguggauaaccuggacacaggcguguugaauugaaaucugcacagcauuugagaagagcucagaccugg


augggguaaaccucagugccacuuccuuuguauugccucuaguauuacugggauugaagagucacugcuucuuguuuagg


agguucauuucauuggcccguuucucccaauuucauacucaagcacugagaauuucaaguggaguauaucgaauaucgaag


uagacuucagguuguuuuuugguuuuguuuuguuuuuuuuuuguuuugguuuuuuuuuuuuuuuucuguuuugguuu


aaaucauuucuguauucaauuuuuuaauucuuucauaacccuauuggguguuuuuuuaaacuaaauuaacauggcucgaa


ugaaccgcccugcuccuguggaagucacauacaagaacaugcgauuucuuauuacacacaauccaaccaaugcgaccuuaaa


caaauuuauagaggaacuuaagaaguauggaguuaccacaauaguaagaguaugugaagcaacuuacgacacuacucuugu


ggagaaagaaggcauucauguucuugacuggccuuuugaugauggugcaccaccauccaaccagauugucgaugacuggcu


aagucuugugaagauuaaguuucgugaagaaccugguugcuguauugcuguccauugugucgcaggccuuggcagagcuc


cggugcuuguugcccuagcauuaauugaagguggaaugaaauaugaagaugcaguacaauucauaagacaaaagcggcgug


gagcuuuuaacagcaagcaacuuuuguaucuggagaaguaccguccgaaaaugcggcuccgcuucaaggauuccaaugguc


auagaaacaacuguuguauucaauaaaacuggggugccugaugccauugccuuggaaguggaacuucagaugggaccugau


uugucaugcauauuacccaaugugucggcuuacugaauaagucuacugcagcuccacaggaauacugaaaaaccagucuua


ccaggccacaaguuugacagaauugcaaccucuauauuugggcuaugaucaacauguuuggacacuuagcaaaagauuuuu


gcuguucagcauuuaaaaugugcuuauuauuuguaccaauugaccuuuccuaaaauaagguauugaguuaugucauuaaa


uguacuccugugccagaauauuauuagucuauaaggaauuuagaaggauuaggugccaaaauacccagcacaauacuugua


uauuuuuagcaucauacagaaccaaaauugcaggaacugagaacucucagaccauccaugguguauuccuucagucauuuc


aaacacugcagggcuccucucguuaucugccugcucacucuguuuacaucucccacacuuaugccagaauacgucagguuu


gcuuagccauccuuuauuuuuuuuauuuuuuuuuuuaacuaagucuugcgcugauuauuuaauaugucugucucauuuu


guuuuguuuugggaaaccucugucugaaaaaucaacuuuguuacagaagcacauaucuucaacaaugucuccagacaaaaa


gccuuauaguuaauuuaauguuugcacucagaagugcaaccuaacagggagggccugaaaaagaaacgagaggaggcuauu


aaauauuuuuaguaauauguugccuuugucaugugcagaacauguagaguaugcucuuaauuuaguaaauauuuuuaaga


cauagagauacauguguagcuaacccauucuuauucaaaauucuggaauuuuguguuuuccnauaccuaucaggaaguuuc


cagcuuguuugaauuauggcuuuccucuucccaaucucuugcaaaaaagacaaagugggaugaaucugcuagugaacugag


cagaaauguuuuauaacgccuuuugagcuauguaacuuaauaauuggauacuugaucauuuguuuuauuauguaaucgga


uaaaauggugauguguauuaaaguuaguucaaccauauauuuauacugucugggaaugugugguuauaguucuguggga


gaaauaguuugucaguguucaccagcuuguaaaaacuuaguaugagagcuucaacauuuaaauaaaugaugaaccgcauuc


gucacugaggacacuuuugccuaaaauuaacuuaauuuguagaaaacaauggauucaguuaauaucauuucaauuuaugga


aaaaauuguuaggguugccaagugcuuuuuauuaaaaguuucucuuuaaaggucuagauaauugugaaucaguugaaugu


ugggcaccgaggggaaacaguuuguaauagaugaucuagauuuuucaguucaguuccaucagucacuuguagcucugcaa


uuuccagaccaguuuucucauuuuuaaguucauuacaugccuguauauauuuugaaauuaacuugaaccugaguauuugg


cacaugauggcuuaauaaauuuuaacuuuc












203
M62362
Sequence below.










acgcuccccaaccuccaccuccccucgcucggccucuauaugcucccgggcucccuaguguuggcuggaagugggugacuu


agaggcuuaaaggaggggcgccuaaccacggaccacgugugugcgggggcgacagcgccgccgggguggggcugagcgcu


gcaagccggguucgccuugcagcgcaggagucagugggcguugcgccacgaucucucuccacuagcacuaugcucccgccc


cacucaccgccuuggaaagucacaggagaaggcgggcucuaagacccagcaggcaccauccuacuggcgccuucgauccgag


acccguuuggacaccagggggcgaugccgacccucuauaaaagcgguccccgcgcgggccuggccauucgcgacccgaagc


ugcgcgggcgcgagccaguuggggcacugggugggcggcggcgacagcggcgccacgcgcaggcuggaggccgccgaggc


ucgccaugccgggagaacucuaacucccccauggagucggccgacuucuacgagguggagccgcggcccccgaugagcagu


caccuccagagccccccgcacgcgcccagcaacgcccgccuuuggcuuuccccggggcgcgggccccgcgccgcccccagcc


ccaccugccgccccggagccgcugggcggaucugcgagcacgagacgucuauagacaucagcgccuacaucgacccggccgc


cuucaacgacgaguuccuggccgaccucuuccagcacagccgacagcaggagaaggccaaggcggcggcgggccccgcggg


uggcggcggugacuuugacuacccgggagccccggcgggccccggcggcgcggucauguccgcgggggcgcacgggcccc


cucccggcuacggcugugcggcggccggcuaccuggacggcaggcuggagccccuguacgagcgcgucggggcgcccgcgc


uacggccgcuggugaucaaacaagagccccgcgaggaggacgaggcgaagcagcuggcgcuggccggccucuuccccuacc


agccaccgccgccaccgccaccgccgcacccgcacgcgucucccgcgcaccuggccgccccccacuugcaguuccagaucgcg


cacugcggccagaccaccaugcaccuacagccuggccaccccacaccgccgcccacgcccgugcccagcccgcacgcugcgcc


cgccuugggugcugcgggccugccuggccccgggagcgcgcucaagggcuuggccggugcgcaccccgaccuccgcacggg


aggcggcggcgguggcagcggugccggugcgggcaaagccaagaagucgguggacaagaacagcaacgaguaccggguacg


gcgggaacgcaacaacaucgcggugcgcaagagccgagauaaagccaaacaacgcaacguggagacgcaacagaaggugcug


gaguugaccagugacaaugaccgccugcgcaagcggguggaacagcugagccgugaacuggacacgcugcggggcaucuuc


cgccagcugccugagagcuccuuggucaaggccauggcaacugcgcgugaggcgcgcggcugcgggaccgccuugggccg


gcccccuggcuggagacccagaggaugguuucgggucgcuggaucucuaggcugcccgggccgcgcaagccaggacuagga


gauuccgguguggccugaaagccuggccugcuccgcguguccccucccuuccucugagccggacucggugcgucuaagau


gagggagucaggccguggugguuucuccuugagaccgagagacuuuuccgcggagcugagcugggggcccggcaguacua


guauuaaggaaguaaccuugugccuuggauacucaaaacucgcuccuuuuccuaccgaguagggggagcaaaaaugugccu


ugauauuuuauuuggaggauuccugcuuccucucgggccucagcuggcccccgugagaaaaaugaagggugcaggcccag


ggcaggaggaagauacaggaagcugagaucccggcagugcccugagcugccccucagucccugucuuuagaggggagggac


uuagguguuggggauuugagucuguguccucacccccagcuacagggagguggagggcuccuaaucccuugcuuuuugca


ccuccaccuacauccccccccccccacucagcuuacaacaggccagguuuccugggugaguucauggagaaugggggcacca


cccccagucagacagaaagcugaguugugaguuagccaugugguaggagacagagaccuagguuucugggcuuugugggg


ugggggauaggaggacacggggaccauuagccuuguguguacuguaugucgccagccgcuguugcugaaggaacuugaag


cacaaucgauccaucccagagggacuggaguuaugacaagcuucccaaauauuuugcuuuaucauccgauaucaacacuug


uaucuggucucugugucccagcggugccuugugcaauggcagugugcacgucuaugcuaaaccaccauuuuauuuggucu


uuuguuuuguuuugguuuugcucugauucuugccaaacugagacucuucacuaacggcugggggaaggagcugagugag


gcucucauucuuuuugguuuagggauguuuggguuuuuucgucugccucccagaggaccaaugaaaugaagugggcuucc


cccucuccccuaguuguccaaggguguauguaguagugggucuuagcuuccuccggcuaagacuuaggcuuccccacccac


ccaaccccauccccaacggcccuggcucugggucuggaaagaaggccaccuccagccaguucauacacacaccccuguggcu


gggagcagggcuggaccgcuuccuucucuucuuuuuuuggggggggggacacaaaguuucaugcuagaugucguaugua


uuauaucuauaauauaaacauaucaaacucaa












204
AA032310
gaagcucagugucgugaaauggaaaccaaaccuuggagccaucgcugaguauaaaaaaaa




ggaagauuuauauucngcaaagaguagccgaacuggacaaaauuacuucugaaagagaua




auuuuagacaagcauaugaagaucuucgaaaacaaaggcugaaugaauuuauggcugguu




uuuacguaauaacaaauaaacuaaaagaaaacuaccagaugcucacauugggaggagaug




cugaacuggagcuuguggacaguuuagauccuuuuucugaaggaaucauguucaguguuc




ggccaccuaagaaaaguuggaagaagaucuuuaaccucucaggaggcgagaaaacccuua




guuccuggccuuaguguuug





205
M94087
Sequence below.










gccgguuugaguugugcgcucgggugucccuuuccucuuccccucccgcagggcuugcggccaccauggcguauuagagg


cagcagugccugcggcagcguuggccuuugcagcggcggcagcagcaccaggcucugcagcggcaacccccaccggccuaa


gccauggcgcucuucacgaaauccagcagcaguguugcuguaacggacaaagauaccuucgaguuaagcacauuccuggaa


uccagcaaagccccacaacaugaccgagaugagcuuccugaacagcgaaguguuggcgggggacuugaugucccccuucga


ccagucggguuugggggcugaagaaagccuaggucucuuagaugacuaucuggagguggccaagcacuugaaaccucaug


gguucuccagcgacaaggcgggcuccucggaauggccggcuauggaugauggcuuggccagugccucagacaccggcaagg


aggaugccuuuuccgggacagauuggauguuggagaaaauggaucugaaagaguuugacuucgaugcucuguuucgaaug


gaugaccuggaaaccaugccagaugagcucuugaccacguuggaugacacaugugaucuuuuugccccucuaguccaagag


acuaauaaggagcccccucagacagugaacccaauuggccaucucccagaaaguuuaauaaaagucgaccagguugcccccu


uuacauucuugcagccuuuccccuguuccccagggguucugucuuccacuccagagcauuccuuuaguuuagagcuaggca


gugaaguugauaucucugaaggagacaggaagccugacucugcugcuuacauuacucuaaucccuccauguguaaaggagg


aagacacucccucugacaaugacaguggcaucuguaugagcccggaguccuaccugggcucuccccagcauagccccuccac


cuccagggccccaccagacaaucugccuucuccaggugguucccgugggucuccucggcccaaaccuuaugacccaccugga


guuaguuugacagcuaaagugaagacugagaaauuggauaagaagcugaaaaagauggagcaaaacaagacagcagccacua


gguaccgccagaagaagcgggcugagcaggaggcccucacuggcgaguguaaggagcuagaaaaaaagaaugaggcucuga


aagagaaggcagauucucuggccaaggagauccaguaucugaaagaccugauagaagagguccguaaggcaagggggaaga


agagaguuccguaauaggguagucaggugcuuugugcuuguacauagucuuguguugcuguguuugcuguaauaaauua


uuuuguagugaaagu












206
AI847609
uuuuuuuuuuuuuuuauguagggaaguucauauuuuauuuguccagugacauuuuuua




caguugaauacaaguuaaaggccugcuugcacaccaaagccagguccuuugggugguuca




gucaaagaaguaaggccuccagcuggcucacaacagaagcggccacuccuuggcccuggu




uu




gggaacuuuuccagcuuugaguucaucaauaaucucuucaauauccuugggugucagauc




cucauaguaguugucauuuauuugaaccaucggugcauuuacacaggccccuaaacauuc




cacuucuauaagagugaaaaguuugucagguguagucucuccaaccuuuauuccaa





207
AI853294
uuuuuuuuuuuuuuuuuggggugaauauagccaaguauuccauuuauuaacaaaauagu




cuuagcaagggagagcucuguucaccccacaagaggccccgcagccgaggccggcccgaag




ccccagcgcugcugcguaagaccgggagggagggaagguguuggggagaagacuuguau




u




aagucuuuaauccuagccaccgcaggaacccacggaaaccuaaugccagcuuuggcgauu




gcuggcucaggucugggacauggcgaagggagugcucugauccuagggcucccugaguc




c




ccagccugcccccaacagagcuccuaaaguugucuggucugcugacuugaggacugguaa




gcuuuggagggauccaucaaggauuccccgaccccaccccuaucgccagggga





208
M33934
Sequence below.










ccucugcggcgcgguccucggagcggcgcgguucucggagccacgcgucugucuuccuccguggucauggcggacuaccu


gauuagcggaggcaccucuuacgugccggacgacgggcucacagcgcagcagcucuucaacugcggggacggccucaccua


caaugauuuucucauucuuccuggguauaucgacuucacugcagaucagguggacuugacgucugcucuaacuaagaagau


uacacuaaagaccccauugguuuccucacccauggacacugucacagaggcuggaauggccaucgcgauggcgcuuacagg


agguauugguuucauccaccacaacugcacaccugaauuccaggccaaugaaguucggaaagugaagaaauacgaacaggga


uucaucacugaccccgugguccuuagccccaaggaucguguacgcgauguuuuugaggccaaagccaggcauggcuucugu


gguauccccaucacagauacaggccggauggggagucgauuggugggcaucaucuccucaagggacauugauuuccucaag


gaggaagagcaugaccgguucuuggaagagaucaugacuaagagggaagauuugguggucgccccugccggcgucacucu


gaaagaggcaaaugagauucugcagcgaaguaaaaagggaaaguugcccauugugaaugaaaaugaugagcugguagccau


cauugcccggacagaccuaaagaagaaucgugauuacccccuggccuccaaagaugccaagaagcaacugcuguguggggca


gccauuggcacucaugaggaugacaaguauaggcuggacuuacuggcccuugcugguguggauguagugguuuuggacuc


uucccagggaaacuccaucuuccaaaucaauaugaucaaauacaucaaggagaaguaucccagucuacaggucauuggaggc


aauguagucacugcugcgcaagccaagaaccucauagaugcagguguagaugcuuugcgagucggcaugggaagugguuc


caucugcaucacccaggaaguguuggccugugggcggccccaagccacagcaguguacaaggucucugaguaugcccgucg


cuuugguguuccuguuauugcugauggaggaauccaaaaugugggucauauugccaaagcuuuggcucuuggggcuucca


cagucaugaugggcucccuccuggcugccaccacugaggccccuggcgaguacuucuucucagaugggauccggcugaaga


aauaccgagguauggguucucuugaugccauggacaaacaucucagcagccagaaccgauacuucagugaagcugacaaaa


ucaaaguggcccaaggaguuucaggggcagugcaggacaaggggucuauccacaaguucguuccuuaccugauugcuggca


uccagcauuccugucaagacauuggugccaagaguuuaacccaagucagagccaugacguacucgggggagcuuaaauuug


agaagaggacauccucugcucagguggaagguggcguccacagccuccauucguacgagaaacggcuuuucugaaaacaga


uccaguauaugccuugaauuuuucaauaaaaguuugggaaaaaaaaagugaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa


aaaaaa












209
X16202
gugugggugcagagcuggggucagggaaagcuggagccuuuugcagacccugagcugcuc




acggcugagagcuggggucauuacccucaccuucauuuccuguaccuguccuucccagag




ccuccuccauccacugucuccaacauggcgaacguagcuguucugguuguccuuggagcu




uggccaucauugcagcugugguggcuuuugugaugaagagaaggagacacacagguagga




aagggcagagucugaguuuuu





210
AI661431
acaggaggggaaggccaaagcaagaaugaaagucccccgccccguaucaccacgggcacu




cggggucacccucaggaacaugcagucucugcacgugaggaaagaaacacgcagagaugg




acgagcacuuuuacacccuaauaaaauuagaugcacuaaccacagaccccccu





211
AI839109
uuuuuuuuuuuuuuuuuaaaaaaaaaaauggcaucuuuuauucaucaaucccuguuacac




acugaaauacaugcaucuuucuuauguuacuuagcaacguccuuucuauccuuucaccca




uaaaucagucugaugaauucaucuuuaaauucaagaaguuuuucuuuuugaaacgcuacu




uacauuuuauugucucaauaucaaagccaaucuagagauuuauucuuccuacaggugaaa




uagauguuaauacgggaacagucaguacauguucaagaugacaucaaaguuaugcccuaa




gcagauauuucaaggcaauaucaugccacuagcucugagacucuaaguaucacugauagu




acuaaaagguagaagucagcuucaaaaacacacucuugcaauggacacugcucaugaugu




cuaagauuguucacucccacagucaugauuucagaugcacaguuuuuuuugcuuuccuga




gcauucgguuugac





212
AI849135
uuuuuuuuuuuuuuuuuaagagugucaccaaagcuuuauuuacaugcgucaucaucucuu




uuacaaacuagauuaugguuuuaaauggaauacacaggcaauaucuacaaacgccacggg




aaguacgcaccuccauuccaccgggaaggggcagauucccaaaucaaacugguuuugauc




cuugagaagaaaggcggcagagcuaacucacggcagcguaugguuagacaagguccucag




uacccagaaugcagcaggauugcgucugccucaaaccagacgaccaacugcugcaggugu




uuaaacauggccacgcgccacacgaaauucuaguuugugugggguagaagcaagaaaaaa




aaaaaaccauggcgccucgugccg





213
M32459
gguccggauaguaaacugcucccuuacaucuccuuaaauauaaaguaaggaaaaagaaaa




aacucaguucggguaaccaaguucaacaaguaauccuuggggccgcugugguaucgccaa




aaucuacauaguaucucuuauuaaaauguuuugacgaaaauguaacaauuacgguacuua




augguaacaauguggcugaggaagcaauaguuaacaaagaggagcuaagcuaugcaacaa




accagauuucuauuggucacaaauuugaaguugagaccuguuauccaauuaccaaguacu




uccgcauacaucaucauaggcauuugaagauuucaaccaaucaggagcauguuccuucua




uaaaggaacccagaaccuaaccucugcauuuccuauuucuuuguagaaauggcucguacg




aagcagaccgcucgcaaguccacuggcggcaaggccccgcgcaagcagcuggccaccaag




gccgcccgcaagagcgccccggccaccggcggcgugaagaaaccucaccgcuaccguccc




ggcaccguggcgcugcgcgagauccggcgcuaccagaagucgaccgagcugcugauccgc




aagcugccguuccagcgccuggugcgcgagaucgcgcaggacuucaagaccgaccugcgc




uuccagagcucggccgucauggcucugcaggaggcgagcgaggccuaccuugugggucug




uuugaggacaccaaccugugcgccauccacgccaagcgugucaccaucaugcccaaggac




auccagcuggcccgccguauccgcggcgagcgggcuuaauaggcacgcuuucuacacugg




cacguaaaccaaaacggcucuuuuaagagccaccuccauuauccaccaaagaugcuugaa




guacaaguugugagaguuuucuaggguuuccuauuauagccuuucuugacaaugugagca




ccacccgacgaagcagucugag





214
AI841389
uuuuuuuuuuuuuuuuuggacuucugcggcuuuuauuuuugcauguaaaccacugggggg




agggggaucuugauggugggcacccuagagauuacacuggaguuccgagggcuccagaca




cuagcugggaagucaggugacagaaacaaugauucagaccaaucacaugauugcaaaacu




gggucuccagcagggauucugguggucagguguggaugccuaaggaagcagugacauggg




aggggcacgcacugggcuggccuugagcugcugggaugacaucagggauagaggaccuag




cagcugguggcuccagggaucuccgguccaugcuuuauuuggccaggggguuccugaagg




accugccagcaaacuuggcuuugcugcccagcucuuccucaauucugaggaucugauugu




acuu





215
X03039
Sequence below.










auucuaaggaucaugucugcgagucaggauucucgauccagagacaauggccccgacgggauggagccggaaggcgucauc


gagaguaacuggaacgagauuguggauagcuuugaugacaugaaucucucagagucccuccuccgugguauuuaugccua


ugguuuugagaagcccucugccauccagcagcgagcuauucuuccuuguaucaaggguuaugaugugauugcucaagccc


agucugggacugggaaaacagcuacauuugccauaucaauucugcagcagauugaauuagaucuaaaggccacucaggcuu


ugguucuggcacccacacgugaauuggcucagcagauacaaaaggugguuauggcauuaggagacuacaugggugccucu


ugucaugccugcauugggggcaccaaugugcgugcugaggugcagaagcugcagauggaagcuccccauaucaucguggg


uaccccuggccggguguuugacaugcuuaaccggagauaccugucccccaaauacaucaagauguucguacuggaugaagc


agaugaaauguuaagccgaggguucaaggaucagaucuaugacauauuccagaagcucaacagcaacacacagguaguuuu


guugucugcuacaaugccuucugauguccuugaggugaccaagaaauuuaugagagacccuauucggauucuugucaaga


aggaagaauugacccuggaggguauccgccaauucuacaucaauguggaacgagaggaguggaagcuugacacauugugug


acuuguaugagacgcugaccaucacccaggcagucaucuuuaucaacaccagaaggaagguggacuggcucaccgagaaga


ugcaugcccgagauuucacuguuucugccaugcacggagauauggaccaaaaggaacgagaugugaucaugagggaguucc


ggucuggcucuagcagaguauuaauuaccacugaccuguuggccagaggcauugaugugcagcaggucuccuuagucauc


aacuaugaccuucccaccaacagggaaaacuacauccacagaaucggucgagguggucgguuuggucguaaggguguggcu


auuaacauggugaccgaagaagacaagaggacucuucgagacauugagacuuucuacaacaccuccauugaagagaugcccc


ucaacguugcugaccucauuugaggggcuguccugcgaccuggcccuagcccaggguucaguccugggguggggcuaagg


aagagcuggaggggggaggggagggagccaagggauggacaucuuguuuuuguuuuggcuuuuuuuuuuuuuuguuuca


guuuuuuuucucuaugaauaaaugucacuuuuugaggc












216
AW049795
uuuuuuuuuuuuuuuuugccaggauauauuuauuacugaaaguacaagcaacugagguuu




acccugggaacacccacaaugaaacguguaucuucccuguuucucagaugcugccuccuu




ccacagagugaguuuucguuuaaaacucauaaugaggagaaggcagggggcuccaccccu




uuccuguucaaucugaagacugaauugggcuacacugggauggagauuucaggugcugca




ggucagugucaaccaaggguucgugugucaggaacucuggcugguaagaugacacaaagg




cuucaugcugaagcucagggagguccagggagccuggcagaauggaaucaucauggucau




caucaaacgucugugucuggaaggcuucaaggcucauaauugcaucauucucuggcaguu




ccugagagagcugccccuuccuggguuugcacgcaucaaauuucacccacugguaauuga




cacaguuuugagcuucgggacaacucuuaaucagguuguggaugguuggaugagaaaacc




caaagaagucggcaccgcauga





217
D87691
Sequence below.










auuguaacagaagaaggaaaggaaaagaaaguuaacauugacuuugaaccuuucaaaccaauuaauacaucauuguauuug


ugcgacaauaaguuucauacagaggcucuuacagcguuacuuucagaugacagcaaguuugguuuuauuguaauagacgg


aaguggugcucuuuuuggcacgcuccaaggaaacaccagagaaguccugcacaaauucacuguggaucucccaaagaaacac


ggcagaggaggucaaucagccuugcguuuugcccguuuaagaauggaaaagagacauaacuauguucggaaaguagccgag


acugcugugcagcuguuuauuucuggagaccaagugaauguggcugguuugguuuuagcuggaucagcugacuuuaaaac


ugaacuaagucaaucugacauguuugaccagagguugcaaucuaaaguuuuaaaauuaguugauauauccuaugguggug


aaaauggauucaaccaagcuauugaauuaucuacugaaguucucuccaacgugaaguucauucaagagaagaaauuaauag


gacgauauuuugaugaaauuagccaggacacaggcaaguacuguuuuggaguugaagauacacuaaaggcuuuggaaaug


ggagcuguacaaauucuaauagucuaugaaaaucuggauauaaugagauacguucuucauugccaaggcacagaagaggag


aaaauucucuauuuaacuccagaacaagagaaggauaaaucucacuucacagacaaagagacuggacaggaacacgaacuga


uagaaagcaugccucucuuggaaugguuugcuaacaacuauaaaaaauuuggagcuacacuagaaauugucacagauaagu


cacaagaaggaucacaguuugugaaaggauuugguggaauuggagguaucuugcgguaccgaguagauuuccagggaaug


gaguaccaaggaggagaugaugaauuuuuugaccuugaugacuacuagguagucgacauggguccggcaaccgugccucac


ccuccagcauucaacccaaggagcauacccgugguggaguccaacagaucccugccuuacaauuggagcauuuccagaacuu


aauccgugagcauuggauacugaaaagaaaagugaaacaaaaccagacccaacccuacacuuugguuugucguggugucag


cgcagcagccgacaacuaagucucu












218
AI117211
cagaggagucauuguugcugugguggcuuuugugaugaagaggaggagaaacacagcgua




agccagcugccuggaguggacuaagugacagacaaugucuucacacaucuccugugacau




ccagagcccucaguuuucuuuagucaaguaucugauguucccugugagccuaugggucaa




agugaagaacugugcagcccagccugcccugcacacagaacccugucccugcacugcccu




ggguucccuuccacagccaaccuugcugcuccagccaaacacugggcgacaucugcaucc




ugccagcuccaugcugcccugagcugcagcuccucacuuccacacugagaguaagaaucu




gaaugggaccuugauucuuaacauccugaccgaggguugauuucuuguuaauuucaugga




uugagaauacuuagaguuuugguuugucuugauuuuuuuucaag





219
Y00520
ugaauaaaaacgaggagccgaagauucuagggggcuacagcugcgcuuuugcagcacuga




acaugguuccggguacucaagauauugcguuuguguuuggagagguguagauuguagauu




ccagccgagaagaccaggaaaagauaaggauaaagaaugucauauaucucaggagcuaga




ucacuucccgaugaacaaguaagaauugccucaacaaaaauggauggaauuggaccgaaa




aaagccauucagcuucguuaucgauuagguaucagugggaacaucaagaugaaugaguua




acuaaguaucagaucgaccaaauugaacaaaugauagcucaagaucauguuguucauugg




gaauugaagaggggagaacgagcagacaucgaacgauuaauuucuauuucucguuaucgu




ggaauucgucaucaagauggaucgcccuuacgcggucaacgaacucauacuaaugcaagg




acugcucgcaagcaaauucggaaaugaaagaaggcuaccgaaagaacaagcaacggauuu




cgcgcucaucccuugcuaaagcgcauacguuuucuugcuccuugguacuugucugaucaa




ucacacuguucauuaguucacuugauuuuucguucgaugucuugaaccgcuuacuaauca




cguauacguauaguaggcccccuucgccacuccacgucuggcccgucuuggucucgcuca




cuucgcccgccuaucguaucggcucggcuucguccgucaagcgacagcuucugccucuga




cggcuucacuaucgcucaugacugguaguacucuauguaguagucggccuuuguuaagcu




u





220
AA638002
uauaaccauguuagaagcggaaguuggccugaaaaccugaggcuuaggcuucauagcugg




gcuguagauuggauuuaaacccaguuggagugcaaagucauggugugcucaaggugauga




cagugaacagaguaug





221
Z22661
caugggccuccugagaga




uccuuagauccagguuagugcauaggaaaguguccccccacuaccuacagcuaagggauu




gggguggugggaucaugguggagggccguggugaauacuagcgaugucccccgcuacccg




ugcgucugccuccagggugccccuccaaccaggaugaggcucuucaucgcucuuccuguc




cugauuguggucguagccaugaccuuggaagguaagaaagagccuuggaagguaagaaag




augcuuggaagugugaaguuggccuugugccugcggcccaggcuuagaagacccucgagg




agggcucugaggucccuuucugugucaucauuccacuaccgcccucccaucgucccccau




cccaccugccaggugccuuauuuuugugucaaagugggugcugaaggaggcaacucuguc




cagaaaagacgcaguaaccaaugaccuaggauaccacccuuuggaauuggcuaaucuucc




uagaaggggcggacgguaaaaacaaggaggugagaggugcaguaaaaucaaguguccaau




acccucccccaugcuaaugaguuugcucgcaacccucucgcggcaggcccagcccccgcc




caggcggccccggauuuguccggaacauuggagagcauaccggauaaacugaaggaguuu




gggaacacuuuggaagacaaggcccgggcagccauugaacauaucaaacagaaggaaauu




uugaccaagacccg





222
X99644
Sequence below.










cagcgccuggggcgcggcgggcgucggcccaggagacgcguggcggcgcucggccucgcggcaucggcggcugccuggcc


guuggcggcgagcgcacuugcgccugcgcagcgggguccgugccccuccuccccugggcggcccccccacccccccggcgg


cgugugaauggcggccucggcggcagcgacugcagcggccucggccgcgacggccgccucggcggccucugguagcccagg


gucgggcgagggcucggcgggcggugagaagcguccggcugcuuccucagccgcggcggccucugcagccgcgucguccc


cugcggggggcgguggcgaggcgcaggagcuucuggagcacugcggcgugugucgcgagcgccugcggcccgagcgggau


ccucggcugcugcccugucuacauucggccugcagugccugccugggccccgcuacacccgccgcagcgaauaauucgggg


gauggcggcucggcgggcgacggcgcuaugguggauuguccagugugcaaacagcagugcuacuccaaagacaucgugga


gaauuauuuuaugcgugauaguggcaguaaggccucuucugauucccaggaugcuaaccagugcugcacuagcugugaag


auaaugccccagccacuagcuauuguguggagugcucugaaccacuuugugagaccuguguggaggcucaccagcgggug


aaauacaccaaggaccacacugugcgcuccacaggaccugcuaagacucgagauggagagcgaacagucuacuguaaugugc


acaagcaugagccccucgugcuguucugugagagcugugacacacucaccugccgcgacugccagcucaacgcucacaagga


ccaucaguaccaguuuuuggaagaugcagugaggaaccaacguaaacucuuggcuucacuggugaaacgucuuggggacaa


acaugccacacuucagaaaaacaccaaggagguucgaagcucgauccgccaggugucugaugugcagaagcgagugcaggu


ugaugucaagauggccauucugcagaucaugaaggagcugaauaagcggggucgaguucuggucaaugaugcccagaagg


ugaccgagggucagcaggaacgucuggagcgccagcacuggaccaugaccaaaauucagaagcaccaggaacacauuuugcg


uuuugccucuugggcucuggagagugauaacaauacagcucucuugcucucuaagaagcugaucuauuuccagcugcauc


gggcccucaaaaugauuguggauccuguggagccucauggugagaugaaguuucagugggaucucaaugccuggaccaag


agugcugaagccuuuggcaagauuguggcugagcguccugguacgaacuccacagguccugggcccauggcuccuccaaga


gccccaggcccucuaagcaagcaagguucuggcaguagccagcccauggaaguacaagagggauauggcuuugggucagau


gaucccuauucaagugcagagccgcauguaucaggcaugaagcggucccgcucuggugagggagagguaaguggccucuu


aaggaaggugccacgugugagccuugaacgccuggaucuggaccucaccucugacagccagccaccagucuucaaggucuu


uccuggaagcacuacugaggacuacaaucugauuguuauugagcguggugcugcugcagcagcugcuggucaggcuggga


cugugccaccaggagccccuggugccccaccccuuccuggcauggccauugucaaggaagaagagacagaagcugcuauug


gagcucccccggcugcccccgaggguccugaaaccaagccuguguugaugccucugacugaagguccuggugccgagggac


cucgucuagcuucaccuaguggcaguaccagcucaggcuuggaggugguggcuccugagguuacuucagccccaguaagu


gggccagguauccuggaugacagugccacuaucugccgagucugccagaaaccaggugaccuggucauguguaaccagugc


gaauuuugcuuccaccuggauugccaccucccugcccugcaggauguuccaggggaggaauggaguugcucacucugccac


gugcucccugaccuaaaggaggaagauggaagccucagccuggauggagcagauagcacuggugugguagcuaaacucuca


ccagccaaccagcggaaaugugagcguguucuccuggcccuguucugccaugaaccaugccgucccuugcaucagcuggcu


accgacucuacauucuccauggagcagccuggugguacccuagaccugaccuugauucgugcucgccuccaagagaagcug


ucaccuccuuauagcuccccccaggaguuugcucaagaugugggccgcauguucaaacaguucaacaagcugacugaggac


aaggcagauguucaguccaucaucggcuugcagcgcuucuuugagacacgcaugaaugaugccuuuggugacaccaaguuu


ucugcugugcugguagaaccaccaccauugaaccuucccagugcuggccuaaguucucaggagcucucuggcccuggugau


ggccccugaagcuggggcucuuguggucagcccaguccagcucuggucucuguauuuucaccccauacccuguccuuugg


uggccugacuccuguucuugcuggccccaucguccccucagucccucuucacaaaaugguuuuuacuucuguggauuuaa


uaaaaacuucacugagucaguuaaaaaaaaaaaa












223
AI843895
uuuuuuuuuuuuuuuuuaaaaauaauuucauuuuuuaauauucuguacaaaauuucucaa




ccuaugaaaauaaaguuugcaaaagucaaaguaguacaugggccugcccuggagccaggc




ccagccggaucuacacuauguacaggucucccagggugagccucagcuagggaaaagcca




cuaaggugccuacagagcaagagggugccaucgggccagugcagccucugcaauuuccag




aucugccacuagaggucggcaugguccugauugcuugucaggcucacccucuggaagacc




acagccaaugacaaagguccucaagggaaagcuuuggggucuagcuggaagugacggugg




guccgccgcccaggcgcaggagcaucugcuggcaguccagcaguaaccggugaucgccaa





224
M38724
uccgucguaaccuguugaguaacuauggaagacuauaucaaaauagagaaaauuggagaa




gguacuuacggugugguguauaaggguagacacagagucacuggccagauaguggccaug




aagaagaucagacuugaaagcgaggaagaaggagugcccaguacugcaauucgggaaauc




ucucuauuaaaagaacuucgacauccaaauauagucagccugcaggaugugcucaugcag




gacuccaggcuguaucucaucuuugaguuccuguccauggaccucaagaaguaccuggac




uccaucccuccugggcaguucauggauucuucacucguuaagaguuacuuacaccaaauc




cuccagggaauuguguuuugccacucccggcgaguucuucacagagacuugaaaccucaa




aaucuauugauugaugacaaaggaacaaucaaacuggcugauuucggccuugccagagcg




uuuggaauaccgauacgaguguacacacacgagguagugacgcugugguaccgaucucca




gaaguguugcugggcucggcucguuacuccacuccgguugacaucuggaguauagggacc




auauuugcagaacuggccaccaagaagccgcuuuuccacggcgacucagagauugaccag




cucuucaggaucuucagagcucugggcacuccuaacaacgaaguguggccagaagucgag




ucccugcaggacuacaagaacaccuuucccaaguggaagccggggagccucgcaucccac




gucaagaaccuggacgagaacggcuuggauuugcucucaaaaaugcuagucuaugauccu




gccaaacgaaucucuggcaaaauggcccugaagcacccguacuuugaugacuuggacaau




cagauuaagaagauguagcccucuggauggaugucccugucugcuggucguaggggaaga




ucg





225
AW122989
uuuuuuuuuuuuuuuuuacuaggcaaagaauuuuauuaacccuuuccaaacuuuauuccc




aggcuucuucagcuuuauuugccgcaaagaaugaauuagguauagcgaaaacugaaaaga




gcugcaguguccgggggcuugggcuuaaaaauauuagagaucuagauuuuaucagaucca




uaauaaacaaaaaaauuuuaaaaagcagucaugauauaaaauagcagcuccuguaauuuc




ugcaaguaucaccuucuucagaaguugcuucaauucaguuugccucauucuuagaagccu




caucaaaauucuccaccagaucuggaacuucaucaucaucauccucuccaguagcaaggg




gugcuuuuccauccacagauuguuugggcagagcuucagccagucuccuuaaacuaguca




ggcugucugcaccaagcugguugaggaugcugggaagcauuucugucagcugcuuuguc





226
AI844810
uuuuuuuuuuuuuuuuuauucaugcuugccuagggauggggaauagaucauucaauaaaa




acauacaguaaaaacaggggguggggagggggaaggcuuaucauguacaauguuuaaacu




acaauagugauguaccuuaauuacuuccaugcacacaagucuaacauuacaaguuuuuaa




aaaauaaacaccauuaagacuucuaggagcauuuuauaauaaauuccuaauuuuuucuuu




guagauagaucaagcaccuccaaaauacagauuccuauacacagugagcacuuuacuuaa




cguacauggacagccucaggacgagcugacgucucggaucagcucggcaggcaacaaacc




auagugccaaauggaaagaagggcaguugcaaauaaacuuaaaacuaaguuaacuuuuau




aauuaaauacagaaaauauacugauuugcuaaaaauaaauaagaugugauguauuuaaca




cuucacuauaaagaaugaacaccaugacauccucgugccg





227
AA940430
agaagaaggaggagugggaccgcaagcaugaggaugcuaguagggaguaugagaaaggca




ugaaagaguaugaaggaggaagaggggacucaucuaaaagggacaagucuaagaagaaaa




agaaaguaaaagcaaagauggaaaaaaaguccacuccuucccggggcucgucauccaagu




cuucauccaggcaguugagugacagcuucaagagcaaagaguuuguguccagugaugaga




gcucuucaggcgagaacaagagcaaaaagaagaggaggcggacgaggacucugaagagga




gcuagccaguaccccuccaagcucagaggacucugccucgggaucugaugaauaaaggag




ggaauucccaccccgucacagcuccagucucucacauaguccuuggauucugugccaucu




gaguaacugcucuugguggcuuccacugcccugaggcuuugagggaag





228
M38381
Sequence below.










aucgucguaaucguuugcagacuucucgccgucgccuuguaagcuuugucuucgccuugcaagcuuugucuucaggguug


gaaagaugagacauucaaagagaacuuacuguccugacugggaugaaagagacugggauuauggaacauggagaagcagca


gcagucacaaaagaaagaagagaucacauagcagcgcccgugagcaaaagcgcugcagguacgaucacuccaaaacgacaga


cagcuauuaucuggaaagcagauccauaaaugagaaagcuuaucauagucgacgcuauguugaugaauacaggaaugacua


caugggcuacgagccagggcaucccuauggagaaccuggaagcagauaccagaugcauaguagcaaguccucugguaggag


uggaagaagcaguuacaaaaguaaacacaggagucgccaccacacaucgcagcaccauucacacgggaagagucaccgaagg


aaaagaucgaggaguguagaggaugaugaggagggucaccugaucugucagaguggagacguacuaagugcaagauauga


aauuguugauacuuuaggugaaggugcuuucggaaaagugguggaaugcaucgaucauaaagugggagguagacguguag


caguaaaaauaguuaaaaauguggauagauacugugaagcugcucaaucggaaauacaaguuuuggaacacuugaauacaa


cagacccccauaguacuuuccguuguguccagauguuggagugguuugagcaucgaggucacauuugcauuguguuugaa


cuucuggggcuuaguacuuaugauuucauuaaggaaaacaguuuucugccguuucgaauggaucauaucaggaagauggc


auaucaaauaugcaaaucuguaaacuuuuugcauaguaauaaauugacucauacagacuugaagccugaaaacaucuuauu


ugugaagucugacuacacagaggcuuauaaucccaaaaugaaacgugaugaacguacuauaguaaauccagauauuaaagu


gguggacuuuggaagugcaacauaugaugaugaacaccacagcacauugguaucuacaagacauuauagagcaccggaagu


uauuuuagcccucggguggucacagccaugugaugucuggagcauaggauguauucuuaucgaguauuaucuuggauuua


caguuuuuucgacucaugauagcagggaacauuuagcaaugauggaaaggauucuuggaccacuaccaaagcacaugauac


agaaaaccaggaaacgcagauauuuccaucaugaucgauuagauugggaugaacacaguucugcuggcagauauguuucuc


ggcgcuguaaaccucugaaggaguuuaugcuaucucaggaugccgaacaugagcuucucuuugaccucauugggaaaaug


uuggaguaugaucccgccaaaagaauuacucucaaagaagcccuaaagcauccuuucuuuuacccacuuaaaaagcauacgu


gauuuauaaacacagugcucugaaaggaaucuuacagacuguaucagucuagcuuuuaauuaaguuauuuuguauagcuu


aauuuguaaaacauuuuauguuuuuuagaugcuuuauuaaauacauggccaaaccaaauaacaucuuucaguaauuauaga


augauuuauuuggaauaaaauuugugcuuaugaauguaaaaaaa












229
AF014371
ggacucgcgacaagcguccucagcgcgaagaggcggacucggaguccucgccuugagccu




ugcaucugagaaguuccagguacuuuguacaacugcaucccagaaccuguguguuuucag




caccuuuauaagugauggcugccaucaggaagaaacuggugauuguuggugauggagcuu




gugguaagacaugcuugcucauagucuucagcaaggaccaguucccagaggucuaugugc




ccacgguguuugaaaacuauguggcggauaucgagguggaugggaagcagguagaguugg




cuuuaugggacacagcuggacaggaagauuaugacugccugaggccucucucuuauccag




acaccgauguuauauugauguguuuuuccauugacagcccugauaguuuagaaaacaucc




cagaaaaauggacuccagaagucaagcauuucuguccaaaugugcccaucauccugguug




ggaacaagaaggaccuucggaaugacgagcacacgagacgggaguuggccaaaaugaagc




aggagccgguaaaaccugaagaaggcagagauauggcaaacaggauuggcgcuuuugggu




acauggaguguucagcaaagaccaaagauggagugagagagguuuuugagauggccacga




gagcugcucugcaagcuagacgugggaagaaaaagucugggugccucaucuugugaagcc




uugugaacgcagccucaugcgguuaauuugaagugcuguuuauuaaucuuaguguaugau




uacuggccuuucauuuaucuauaauuuaccuaaga





230
Z30939
uucaagaccgaccugcgcuuccagagcucggccgucauggcucugcaggaggcgagcgag




gccuaccucgugggucuguuugaggacaccaaccugugcgccauccacgccaagcguguc




accaucaugcccaaggacauccagcuggcccgucgcauucguggggagagggcguaaauu




aggguagugagugaauuuggaccccaaaggcucuuuucagagccacccacauuuucuaua




aaaggcuguauaucgauaagcuuuuauaaaccccacucagcaacucc





231
U28208
uuaugugauaaaaaaauucaacuugguauuaacuuaacuaagggccuuggugcuggugcu




uugccugauguugguaaaggugcagcagaagaaucaauugaugaaauuauggagcauaua




aaagauagccauaugcucuuuaucacagcagggauggguggugguacuggaacaggugcu




gcaccgguaauugcaaaagcagccagagaagcaagagcgguaguuaaagauaaaggagca




aaagaaaaaaagauacugacuguuggaguuguaacuaagccguucgguuuugaaggugug




cgacguaugcgcauugcagagcuuggacuugaagaguugcaaaaauacguagauacacuu




auugucauucccaaucaaaauuuauuuagaauugcuaacgagaaaacuacauuugcugac




gcauuucaacucgccgauaauguucugcauauuggcauaagaggaguaacugauuugaug




aucaugccaggacugauuaaucuugauuuugcugauauagaaacaguaaugagugagaug




gguaaggcaaugauugguacuggagaagcagaaggagaagauagggcaauuagugcugca




gaggcugcgauaucuaauccauugcuugacaauguaucaaugaaaggugcgcaaggaaua




uugauuaauauuacuggugguggagacaugacucuauuugaaguugauucugcagccaau




agagugcgugaagaaguggaugaaaaugcaaauauaauauuuggugccacuuuugaucag




gcgauggagggaagaguuagaguuucuguucuugcaacuggcauugauagcuguaacgac




aauucaucuguuaaucaaaacaagaucccagcagaggaaaaaaauuuuaaauggccuuau




aaucaaauuccaacauuagaaacaaaagaauaugcuucaacugag





232
AV218217
ugaucaggucacauuccggugccuuccacccccuauggcacgggcgccccgccuugccau




accacagcucccuccaggcuuagaccuggcuucaccgcauuucaggugcuauaccccccc




cugcuuuuccccccauugcccuuaaaugccccucggccccuccauccccccggaacaggg




uggcacuugccacucucaggaccaccuugccaaggagaauaaaccgaauccuguugcu









Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, anagen can be induced by activation of these transcripts, proteins, and pathways.


Example 9
Molecular Pathways Activated During Induction of Epidermal Cells to Differentiate into HF Stem Cells

The gene expression pattern of HF stem cells was analyzed as described in Example 8 and compared to non-bulge basal keratinocytes. 157 genes were differentially expressed in the HF stem cells, as assessed by microarray analysis and quantitative polymerase chain reaction (qPCR). A group of selected genes with increased expression in HF stem cells is depicted in Table 4. A group of selected genes with decreased expression in HF stem cells is depicted in Table 5.









TABLE 4





Genes up-regulated in HF stem cells. Numbers in parentheses are the fold increase


as determined by quantitative real time PCR.


















Gene Name/





Protein





name/


SEQ


GenBk
Fold

ID


Acces #.
Incr.
Sequence
No.










Cell surface proteins










Cd34/Cd 34
 43
uuuuuuuuuuuuuuuuucacucaucacguuuauucagaagagaauaca
233


antigen
(189)
cccaauccucucaucucuggaaaguuuuguuccuagccaucauuaagau



AI847784,

caggaccccuguucuccccuuaaccccaggagaggaagcuuauagucuu



AI173145

uguagauauucugaaccucugaucacaaaggguuauaaaauagugaagg





gguuuggacuaggaaaggcacagacugaaaggaaucugccaggggacug





aggccacagcucccccaggagucagaggaagggggaagucacguauuuu





auagaaggccaagggccucagagcaagaguauuccuuugaagagcuca










Calcium-related










S100a4/
 35
ugguggagcaggucucaggaaucucuucgcuucagcuucaaucauggcc
234


S100A4
(144)
uguggucuggucgccagcaaccugaaucucaaaccuggggaaugucuca



(mts)

aaguucggggagagguggccucggacgccaagagcuuugugcugaacc



X15986

ugggaaaagacagcaacaaccugugccuacacuucaauccucgcuucaau





gcccauggagacgccaacaccauuguguguaacaccaaggaagauggga





ccuggggaaccgaacaccgggaaccugccuuccccuuccagcccgggag





caucacagaggugugcaucaccuuugaccaggcugaccugaccaucaag





cugccagacggacaugaauucaaguuccccaaccgccucaacauggaggc





caucaacuacauggcggcggauggagacuucaagauuaagugcguggcc





uuugagugaagccagccagccuguagcccucaauaaaggcagcugccuc





ugcu










Transcription Factors and related genes










Id2 helix-
 11 (25)
gugguucuucggcgccagguucgcccgcuucugcccuuagguaacauu
235


loop-helix

cucuaaacugcguuucucucccaaucuuuugcaggcauuuggggacuu



protein

uuucuuuucuuuuuacuuucucuuuuucuuuugcacaagaagaagucu



AF077861

acaagaucuuuuaagacuuuuguuaucagccauuucaccaggagaacac





guugaauggaccuuuuuaaaaagaaagcggaaggaaaacuaaggaugau





cgucuugcccaggugucuuguucuccggccuggacugugauaccguua





uuuaugagagacuuucagugcccuuucuacaguuggaagguuuucuuu





auauacuauucccaccauggggagcgaaaagguuaaaaaaaagaaaaaaa





ucacaaggaauugcccaauguaagcagacuuugccuuuucacaaaggug





gagcgugaauuccaggaggacccaguauucgguuacuuaaaugaagucu





ucggucagaaauggccuuuuugacacgagccuacugaaugcuguguaua





uauuuauauauaaauauauauauauugagugaaccuuguggacucuuu





aauuagaguuuucuuguauaguggcagaaauaaccuauuucugcauuaa





aauguaaugacguacuuaugcuaaacuuuuuauaaaaguuuaguuguaa





acuuaacccuuuuauacaaaauaaaucaaguguguuuauugaauguuga





uugcuugcuuuauuucagacaaccagugcuuugauuuuuuuuuaugcu





auguuauaacugaacccaaauaaauaccaguucaaauuuauguagacug





uauuaagauuauaauaaaaugugucugacaucaa






Id4
  4 (12)
cgaugaaggcggugagcccggugcgccccucgggccgcaaggcgccguc
236


AJ001972

gggcugcggcggcggggagcuggcgcuacgcugccuggcggagcacgg





ccacagccuggguggcucggcagccgccgccgccgcugcggcggccgcg





cgcugcaaggcggccgaggcggcggccgaugagccggcgcugugccugc





agugcgauaugaacgacugcuacagucgccugcggaggcucgugccuac





caucccgcccaacaagaaagucagcaaaguggagauccugcagcacguua





ucgacuacauccuggaccugcagcuggcgcuggagacucacccugcuuu





gcugagacagccgccaccgcccgcgccaccucuccacccggccggggcuu





guccggucgcgccgccgcggaccccacucaccgcgcucaacacugacccg





gugagaagccuuggcgggcacccugggcaucgcgggaaagguggcggg





gcggcgagauacggguggucuugcuccucucagggaaugacagccgcu





ucucccgucuccaccgagagccgccugcugggcuuggugauccacuggu





cccugagccgagggcgguugggcuuggagcccugcgucuccggagugu





cccuugcaucacaggaggcuuccccagcuucgggcucggguggggacuc





ugcucaccugccuaguuuuccaggacgucuccugggugguggcgacac





ugugauaugcgcacucuaaccgcuuuuccccuugguguuggguugcug





uuccaggccggcgccgugaacaagcagggugacagcauucucugccgcu






Peg3/
 12
Sequence below.
237


Paternally





expressed





gene 3 zinc





finger





protein





AF038939










acuagucucgaccauguaccaucacggagacgacaccaacagugacaugaacagugacgacgacaugagccgaagugggaga


gaaaccccacccccucgaccaucucaugcuuuuggcagugagcgagaccuggagcgcaggggcagaagcagagauguggag


ccucgagaccgcuggccauacaccaggaaucccagaagcaggcugccucaacgggaucuuucucuuccugugaugucaaga


ccacauuuuggacuggacagagaugaugacagacguuccauggauuaugagucucgaucccaggaugccgagucauaccag


aauguuguggaacucaaagaggacaagaagccucagaauccaauucaggacaaccuggagaacuacagaaagcugcucucgc


ugggaguccagcuugccgaagaugaccgacacucucacaugacacaaggccacucaucgagguccaagagagcugccuaccc


aagcaccagccgaggucucaaacccaugccugaggccaaaaagccaucccacaggcgugggaucugugaggacgagucuucu


cauggagugauaauggaaaaauucaucaaggauguggcucgcaaccccaaauccggaagagcaagggagcugaacgagcgu


ccuccuccaagguuccccaggccuaaugauaacuggaaggacaguuccuccagcagaagagagucagugauccaggagagg


gguuaugaagggagcgcauuuaggggcggcuuccgguucaacgcagaccuggcuuccagaagcagagcucuagaaaggaag


aggcguuaccacuuugauucugaugagcgggguucgggccaugagcauaaaagcugugugaggaagaagccuuuugagug


uggugcugagaugagacaggcuaugagcaugggcaaccugaacagcccuuccuucucugagucgcagucaaucgauuuug


gggccaacccauacgugugugaugagugcgggaggcaguucagugucaucucugaguuuguugagcaccagaucaugcac


acuagggagaaccucuaugaauauggagaguccuuuauucauagcguggcugucaaugaggugcaaagaagucagggugg


ggggaaacgcuuugaguguaaggaauguggagaaaccuucaguaggagugcugcccuggcagagcaccgccaaauccaugc


uagagaauaucuugcagaauguagagaucaggaggaugaggagaccaucaugccuagcccgaccuuuagugagcugcagaa


gauguauggcaaagauaaguucuaugagugcaaggugugcaaggagaccuuucugcacaguuccgcccugauugagcacca


gaaaauccaugguagaggcaacucagaugacagagauaaugagcgugaacgcgaacgugaucgucuacgugcacgugcacg


agagcagcgugagcgcgaacgugaacgggagcgugagcgugagcuuggggaacccuuucugaccuguccaaacuucaauga


guuucggaagauguacaggaaagacaaaaucuaugagugcaaaguguguggggagagcuuucuucaucucucaucccuga


gggagcaucagaaaauccauacuagaggaaacccauuugaaaauaagagcaggaugugcgaggagaccuuugucccuaguc


agucucuccgacggcgccagaaaacuuacagagagaagcuguucgacuuuaacaaugccagggaugcacugaugggaaacu


cagacuccagcgagcaucagaaaaaccguucccgaaggaacuucuuugagggcagaggauuugagaaacccuucguugaau


cucagaagagucauacuauaacaagaccaccugaaaacaaagacgaugacaagccguucacaaucagugucaacccuaaugac


aagcugaaacuccccaucauggaaaauggcucccagggcaaauccugugagaggucuguuauucauagcuugggcuccgca


gaagcucagaagagucaugguggacugggguucaguaaaccaagaccaguggcagagucuagcacccagagcucaagcagc


auuuacuaccccagagcacacucuggaggcaacaccuaugaaggaaaagaauacaaggacucuaucauccauagcuugccag


cuccucgaccucugaaacgucauagagcaaaugaccauauucaaugugaugaggggggagaauccuccauuuauaucccag


auauuauuaauaagggaaggaagauuccugccagagaagaugcuuaugaaggaaguagcagcagcaacuaccacacaccaaa


uguaucccgugcugagccuccaagucuuucuggagagucccaugacucuaagcaggaugucacguuuucaguucccagcuc


aaguguucgugaacaccagaaagcucgugccaaaaagaaguacauugagcccaggaacaacgagaccucuguuauccacucc


cuaccuuuuggugaguugcuugcaggucaccguagggcaaaguucuuugagugucaggaaugcggggaggccuuugcucg


uaggucugagcucauugagcaccagaagauucaugauagagaaagaccuucuggaagccgacauuaugagcgcucugucau


ccgcagccuugcgcccagugacccucagaccaguuaugcccaagaacguuucauccaagaacaagugcguaaauucagagcg


uuuggacaacgcucaacuaccagcaacaaccucaguguacagaaaaucuaugcccaagagacauuuaaugccgaggagcccc


augauaaagaaacucauggucaaaaaauucaugacaaagagccauaugguaaggagcccaguggcaaggagccccaugguga


ugagccccaggacaaagaaccccuuguucaggagaugcgcagugaagagccccaugaugauaagccccauggccaggagccc


caugaugauaagccccauggccaggagccccaugaugauaagccccauggccaggagccccacggugaugagccccauggcc


aggagccccacggugaugagccccaugacaaggaacccauugaucaggagaugcgcagugaagagccccacagugaagaguc


ucauggugaugagccccauggugaagagucccauggccaggagaaaguugaagaugcuaccauucaggccucaguuucuga


agagcaucagaaagaugacgcuggugaugcaaucuaugaaugccaggacugugggcugggcuuuacugaucucaaugaccu


cacaagccaccaggacacccauagcagaaaggcucugguugacagucgugaauaugcacauucugaaguucaugcccacucc


gucagcgaauuugagaaaaaaugcucuggagagaaacuauaugaauguccaaaauguggggagucuuucauucacagcucg


uuacuuuucgagcaccagagaguucacgaacaagaccagcuguauuccguaaaggccuguuaugacgcuuucaucgcucug


uugcccguuagaccaaggagaaauugcacuguugaaaggaauccugccguuucugggucagccauucgaugccgucagug


uggacaaggcuucauucacaguucugcccuaaaugagcacaugagacagcacagagauaaugaaauaauggaacagaguga


gcuuucagaugagauuuucauucaaggccuagcccucacugaguaucaggggagugaaacagaagagaagcuuuucgagug


cacaaucuguggggaaugcuucuucacugccaaacagcucggggaccaccacaccaaaguucacaaggaugagcccuaugag


uaugggcccuccuacacccaugccuccuuucucaccgagccccucaggaagcacaucccacuguacgaaugcaaagauugcg


gccaguccuuccuagacgacacugucaucgcugagcgcaugguguuucauccugagcgagaaggugggucagaaauaguag


cugccacugcccaagaggucgaagccaauguccucaucccacaagaaguacugcgaauccaggggucaaaugcagaagcugc


ugagcccgaaguggaggcugcagagcccgagguggaggcugcagagccugagguggaggcugcagagccuauuggagagg


cugaagggccagauggagaagcugcugagccugauggcgaggcugagcagcccaauggagaggcugaacagccaaacggug


augcugacgagccagacggagccgggaucgaagacccagaagagagagcugacgagccugaggaagacgucgaagagccag


agggagaugcagaugagcccgauggugcagacauugaagacccagaagaggaaggagaagaucaagagauugagguugaag


aaccauacuacaacugucaugaaugcgcagaaacguucgcuuccagcucagccuuuggcgagcaucugaaaagucacgccag


ugugaucaucuucgagccggccaaugcuccuggagagugcucuggcuacauugaacgggccagcaccagugcagguggug


cggagcaggcagacgacaaguacuucaaaugugaugugugcgggcaacucuucaacgaccgccucucccuugccagacacca


gaauucucacacugguugaguaaccaggcugaagaaaagaagagcaaagccaaaccuucuucccagaaccagacccuuaaua


aaucacaaagagagccuaaaccaacccauaaugucuauaagaaauucaccuuccuguauacauaccggacuucacaucaaaga


cuuucacucucaucacagacugaaaaaagaaaagacauugaacgcagggacucuuucaguuuuagcuguucccuauggaac


aucaguguauauuugggaaagcuagagugaacaucuacaucuuccauuucaucuaaguaacuagauugagggaaaccuagu


gacaauuccagaccacagagguugccccagucgacuguaaaugauaccccuuucauacccuauacauaaugauuccugccau


guauauaaaugagcaaaucagugauacauauauuuggauuuagugugcuauagaauuuacaguuuacucuacagagcuacc


uagccugguacucugauuuuuucccugaggaggaagagagcaacaauuuagcauauauuuguaaguauuguccaugcaga


agcuuuucugugcaucauuugaaccccauuaguauccuuuccaguaauggaguguucuguccccuaccucuuagauagucc


ugugaaggugugggugugaaagaucgugugucuuugaauccuggcuguguggaaacaggcauuuuagcuucuacagccau


uuggugugcacccagaccccuugagacugauuguguaacccuuuacaauauauggauuugucucugugacccaaaucaacc


caucccuacauuuauauaccuuacagugguuuucuugc





Growth Factors, Receptors and Related genes










Fz2/
  9 (17)
uuuuuuuuuuuuuuuuuaccguucuuuauuuaaaaaaauaaaauagga
238


Frizzled 2

guccguagggugcacccuccccccuccugagugaaggagggcacggugc



AW123618

aguccggaccugggagaggggaaagcccggcaggcaggcgagaccgcuu





cacacaguggucucgccaugccggcuguuggugagacgaguguagaacu





uccuccacgagugcagugucuugccggaccagauccagaagcccgacgu





gaugcccacgaugagcgucaugagguauuugaucauguagacugugaa





gucgggcgacaugcggggcguguagugggccgggcaggggauggcuag





gcucuugcagugcuggcuuacccaggagcgcucccagugcucgcggaag





gccugcucauagaaguagcaggcgaug






Dkk3/
  6 (22)
Sequence below.
239


Dickkopf 3





AJ243964










ggccgcgucgacgccucuccagcugcucuguggcagcccagcuaccggucgugaccagauccagcuugcagcucagcuuug


uucauucgaauugggcggcggccagcgcggaacaaacaugcagcggcucggggguauuuugcuguguacacugcuggcgg


cggcgguccccacugcuccugcuccuuccccgacggucacuuggacuccggcggagccgggcccagcucucaacuacccuca


ggaggaagcuacgcucaaugagauguuucgagagguggaggagcugauggaagacacucagcacaaacugcgcagugccgu


ggaggagauggaggcggaagaagcagcugcuaaaacguccucugaggugaaccuggcaagcuuaccucccaacuaucacaa


ugagaccagcacggagaccagggugggaaauaacacaguccaugugcaccaggaaguucacaagauaaccaacaaccagagu


ggacagguggucuuuucugagacagucauuacaucuguaggggaugaagaaggcaagaggagccaugaauguaucauuga


ugaagacugugggcccaccagguacugccaguucuccagcuucaaguacaccugccagccaugccgggaccagcagaugcu


augcacccgagacagugagugcuguggagaccagcugugugccuggggucacugcacccaaaaggccaccaaagguggcaa


ugggaccaucugugacaaccagagggauugccagccuggccuguguugugccuuccaaagaggccugcuguuccccgugu


gcacaccccugcccguggagggagagcucugccaugaccccaccagccagcugcuggaucucaucaccugggaacuggagcc


ugaaggagcuuuggaccgaugccccugcgccaguggccuccuaugccagccacacagccacagucugguguacaugugcaa


gccagccuucgugggcagccaugaccacagugaggagagccagcugcccagggaggccccggaugaguacgaagauguugg


cuucauaggggaagugcgccaggagcuggaagaccuggagcggagccuagcccaggagauggcauuugaggggccugcccc


uguggagucacuaggcggagaggaggagauuuaggcccagacccagcugagucacugguagaugugcaauagaaauggcu


aauuuauuuucccaggaguguccccaaguguggaauggccgcagcuccuucccaguagcuuuuccucuggcuugacaagg


uacagugcaguacauuucuuccagccgcccugcuucucuggcuugggaaagacaggcauggcggguaagggcagcgguga


gucgucccucgcuguugcuagaaacgcugucuuguucuucauggauggaagauuuguuugaagggagaggaugggaagg


ggugaagucugcucaugauggauuugggggauacagggaggaggaugccugccuugcagacguggacuuggcaaaaugua


accuuugcuuuugucuugcgccgcucccaugggcugaggcaguggcuacacaagagcuaugcugcucuguggccucccaca


uauucaucccuguguuucagcuccuaccucacugucagcacagcccuucauagccacgcccccucuugcucaccacagccua


ggaggggaccagaggggacuucucucagagccccaugcucucucucucaaccccauaccagccucugugccagcgacagccc


uuccaaauggagggagugaaauccuuugguuuuauuauuuucuccuucaaggcacgccugccacuaaggucaggcugacu


ugcaugucccucuaacguucguagcagugugguggacacugucuuccaccgacugcuucaauaccucugaaagccagugcu


cggagugcaguucguguaaauuaauuugcaggaaguauacuuggcuaauuguagggcuaggauugugaaugaaauuugca


aagucgcuuagcaacaauggaaagccuuucucagucacaccgagaagucacaaccaagccagguuguguagaguacagcug


ugacauacagacagaagaaggcugggcuggaugucaggccucagaugacgguuucaggugccaggaacuauuaccauucug


uaucuauccagaguuauuaaaauugaaaguugcacacauuuguauaagcaugccuuucuccugaguuuuaaauuauaugua


uacacaaacauguggcccucaaagaucaugcacaaaccacuacucuuugcuaauucuuggacuuuucucuuugauuuucaa


uaaauacaaauccccuucaugcaaaaaaaaaaaaaaa













Sfrp 1/
  6
Sequence below.
240


Secreted





frizzled-





related





protein 1





U88566










gcacgagcagcccgcagcccgccgcgccugugcgagccgggacagcacucggccccgcgcgcuccccgccccgcgccagccc


cgccgcggcgaccugcugcagcggaggaccccaucgaucggagacccggggagcagcgcgcagcccgcgagccgacgggcc


ccgacugcgucuuuguccccggaggcuccgggaaguuugcagcgggacgcgcgcgugaaggcagcgugggcagccccgac


gucgccgagcaacaugggcgucgggcgcagcgcgcggggucgcggcggggccgccucgggagugcugcuggcguuggccg


ccgcucugcuggccgcggguucggccagcgaguacgacuacgugagcuuccaguccgacaucggcucguaucagagcgggc


gcuucuacaccaagcccccgcagugcguggacaucccgguggaccugaggcugugccacaacgugggcuacaagaagaugg


ugcugcccaaccugcuggagcacgagaccauggcagaggugaagcagcaggccagcagcugggugccgcugcucaacaaga


acugccacaugggcacccaggucuuccucuguucgcucuucgcgcccgucugucuggaccggcccaucuacccgugucgcu


ggcucugcgaggccgugcgcgacucgugcgagccggucaugcaguucuucggcuucuacuggcccgagaugcucaaaugu


gacaaguuccccgagggcgacgucugcaucgccaugaccccgcccaauaccacggaagccucuaagccccaagguacaaccg


uguguccuccaugcgacaacgaguugaagucagaggccaucauugaacaucucugugcaagcgaguuugcacugaggauga


aaaucaaagaagugaagaaggaaaacggugacaagaagauuguccccaagaagaagaaacccuugaagcuggggcccaucaa


gaagaaggagcugaaggcgcuugugcuguuccugaagaacggugccgacugucccugccaccagcuggacaaccucagcca


caacuuucucaucaugggccgcaaggugaagagccaguaccugcugacagccauucacaagugggacaagaaaaacaaggag


uucaaaaacuucaugaagagaaugaaaaaccacgagugucccaccuuccagucuguuuuuaagugauacuggggcggacug


gggaaggggaguguggcuuggggugagggugggggcgcguggaugacccuggcucuunggggcucacauauugcucuca


cccauacaguuguggcuuuugcauugcaccuggcucuguuccuacagcgaacccucucccuunccuccauagccacaucca


gcuaaggccacggccuuuagauuaggaaggcuuuuuuuuuuuuaagggcugcagcagggccagcagcgacgugcaaaagg


agaggcagaauccuuucacugagccuggggcacaaaaaacagaaaauguunnccgguuuggaaaaacaaaacaaaacggauu


guaaagaacugcagacggacagcugcucagcucaacguuguucgggacaucauuaccaauugcuuguggagucuaagccuc


uacagguagaagagucugaucauugccaagccaggcugcuuucaguuuauuauuaaucccccucuuucugccuuagauaga


ccaucgccaccuucaaaacacacacacacacacacacacacacacacacacacacacacacacacacacacacuucugaaaguag


ccaggguaucccaguauagaacgggauagcuaaggguuugggugggaggccacugcuacucuaccuucagcuuuugaacu


ggccaccuuugauaggaaacugaggucucagauggacacuucuaccaguccaucgggauacaaggaugccaggcaaggguc


ugcuuuugucugaaggagguacgugggcaugaagagacaugaggcauuucaggcugagaagcaacagcuacuaguuuuca


acaauagaguggaagaaaugagcaaagguagaaaugucaagcaggucacaagucagggugauugggggaauccugugccaa


cagccucacuuuguaauuccaucugucacuuucaaaagaacagcagcauaagacagggauaaaagcccacauacccuccaag


gcuugaguaaaaguccacacucagcauuucaaagacuaacgucguugacugcccaaggcugcccucuuaauacaccgccuau


gcaugugcuguggaaggcaacucugugcaugugcuguggaggagaugggccucauggcugugcuggcugcccggaaucag


uauagcguggaaggagacaguauccauagacucugcuuuucugcaaggaaagcccuuuuccuuauacaugauugccuauaa


uucagacaaauuuaaaaucgcugccugccugagcccuccaccuuuacuuuugcauucuccggucauauucuuuugaggcua


aagugcccuauccgaggagaugguuucaaaggcuaacuaaucugcagcuuucccaagugcccagagguauuucucaaaguu


gguaugcuuaauaagugauguaaauauuccaguucucuuaggcagccuuacuccuguugucccug













Dab2/
 15
Sequence below.
241


Disabled





homolog 2





U18869










aauuccgaguggccgcgcggcuauuuaaguggcguuacuccgcguccucggcgcugcagccuugaggcuucgggcgcggg


ggaagucaugcuggcuccacagaagcacuagcuaguccguguacuuuguggguucuguccuuuugagaccugcccgccgg


ggauuggcugguaucagugacugucuacugcuggauuuucugcuugccuucccgucaugucuaacgaaguagaaacaagc


acaaccaauggccagccugaccaacaggcugccccgaaagcgccaucaaagaaggagaagaagaaagguucugaaaagacag


acgaguacuuguuggccagguucaaaggugaugguguuaaauacaaggccaagcuaaucgguauugaugaugugccugau


gcucgaggagacaaaaugagucaggauucuaugaugaaacucaagggaauggcagcagcuggucgcucucagggacaacac


aagcaaagaaucugggucaacauuuccuugucuggcauaaaaaucauugaugagaaaacugggguaauugaacaugaacau


ccaguaaauaagauuuccuucauugcucgugaugugacagacaacagagcauuugguuauguguguggaggugaaggcca


gcaucaauuuuuugcuauaaaaacagggcaacaggcugagccauuagucgucgaucuuaaagaccuuuuucaaguuaucua


uaauguaaagaaaaaggaagaagauaagaaaaagguugaagaagccaacaaagcagaagagaauggaagugaggcccuaaug


acccuugaugaucaagcuaacaaauugaagcuggguguugaccagauggauuuguuuggggacaugucuacaccuccugac


cuaaauaguccaacagaaagcaaagauauccuguuaguggaucuaaacucugaaaucgacaccaaucagaacucuuuaagag


aaaauccauucuuaacaaauggagucaccuccuguucucucccucgaccaaagccucaggcauccuucuugccugagaacgc


cuuuucugccaaucucaacuucuuucccaccccuaacccugauccuuuccgugaugaucccuuugcacagccagaccaaucg


gcacccucuucguucgauucucucacaucuccagaucagaagaaagcgagucugaguagcucgucuacuccacagaguaaa


gggccccugaacgucgauacugauuacuuuggucagcaauuugaccagcucucuaaccggacuggcaaaccggaagcucag


ggaggcccguggcccuacccaaguucgcagacccagcaagcagugagaacucaaaaugggguaucugaaagagaacagaacg


gcuuccauaucaaaucuuccccgaacccuuuugugggaagcccucccaaaggacuaucgguaccgaauggcguaaagcagg


acuuggaaaguucuguccaguccucagcacaugacuccauagccauuaucccaccuccacaaaguaccaaaccaggaagagg


cagaaggacugcuaagucuucagcaaacgacuugccugcuucagacaucuuugccucagaaccuccaggccagauguccccc


acaggacaaccugcagucccgcagucgaacuuccuggaucucuucaaaggcaaugcuccucccccaguggggccccuugua


ggucuagguacggucccaguaacacccccccaagcaggacccuggacgccuguugucuacaguccuucgacaacugugguc


ccaggagccauaauaaguggccagccucccaguuuucgccagccacucguuuuugguacaaccccagcaguacaagucugg


aaucagucuccaucauuugcaaccccagcuuccccuccaccccccacaguuugguguccuaccacaucuguggcgcccaacg


cuuggucauccacaagcccucuggggaauccuuuucagaguaauaauaucuuuccaccucccaccauguccacucaguccuc


uccucagccuaugauguccucuguucuggccacaccgccucaaccaccuccccgaaauggcccacuaaaggacauucccagu


gacgcuuucacuggcuuagacccccuuggggauaaagaggucaaggaagugaaagaaauguuuaaggacuuccagcugcgg


cagccaccucuuguucccucaaggaagggggagacgccucccucugggacuucaagcgccuucuccaguuacuucaacaau


aaaguuggcauuccucaggagcauguagaccaugaugauuuugaugccaaucaacuguugaacaagauuaaugaaccacca


aagccagccccgagacaagguguccucuuggguaccaagucugcugacaauucacucgagaacccuuucuccaaaggguuc


agcucaucaaaccccucugugguuucucagccugcaucuucugauccccacaggagcccuuucggaaauccuuuugccuag


cuucugaaguuguaaugaugacuauccagaugagcaaaagacuggcuuuggucaagaaugaagcagacagccagaaacaug


uugaccucuguccucgcuccagcuuugacguauuaucuguuacccuauuuguuuuggccucuuguacuuguaaaaugccu


uucauuuuccugucuaggcuaaagcuaaacuuaaacuauggcuuuacguaaauuaagcuccuaaacucucuagcuccaaua


uaaaugaaguagcuucccuaucaaaucccugucuguugugcccccuugaaacuuccagaauauucuccauucuacccucca


uuugggaggagcggcuaccuuuacccuuaauaucacacugccuugagucaauguccaaauacucauagcucucaaagucau


uugggguuccuggugugcggccuaaaccuaaagcauccuauuaauagggaaguaagacaccuugcuuccuauguccacuca


gggagaauuuuauuuaauaaaaugaaagcaagacuaacuucucaaauccacccaaggaccauuuugagauggucguuucuc


agcuaacugcaccauuuaccaauccugccccaaguggugcuuacauuugacuugaagaagagaaagagcuaacucaaaacac


aaggcauuauucaaagcuaauaaaacaauuucucccuggggccccacauuguuuucauuccagauacguugcagcuguuug


acccugaugacauuaugcccuacauuuuccuugaagauccugauuuuauuucaugugauuuuuguuucucaauaaagaug


auuauugugugcacggaauuc













Cktsf1b1/
 12 (12)
Augaaucgcaccgcauacacugugggagcguugcuucuccuccugggg
242


Gremlin,

acccuacugccaacagcugaggggaaaaagaaagguucccaaggagccau



Cysteine

uccgccuccugacaaggcucagcacaaugacucugagcagacccaguccc



knot

caccacaaccuggcuccaggacccgggggcggggccaggggcggggcac



superfamily

cgccaugccuggagaggaggugcuugaguccagccaagaggcccugcac



1, BMP

gugacagagcgcaaguaucugaagcgagauuggugcaaaacucagcccc



antagonist 1

ugaagcagaccauccacgaggagggcugcaacagccgcacuaucaucaac



AF045801

cgcuucuguuauggccagugcaacuccuucuacauccccaggcacaucc





gaaaggaggaaggguccuuucagucuugcuccuucugcaagcccaagaa





guucaccaccaugauggucacacucaacuguccugagcuacagccaccca





ccaagaagaaaagggucacacgcgugaagcagugccguugcauauccau





cgacuuggauuaa






Fgfr1/
 10
Sequence below.
243


Fibroblast





growth





factor





receptor 1





U22324










guggaauauccauggagguacggagccuuguuaccaaccuuuaaccgcagaacugggauguggggcuggaagugccuccu


cuucugggcugugcuggucacagccacucucugcacugccaggccagccccaaccuugcccgaacaagcucagcccugggg


agucccuguggaaguggagucucuccugguccacccuggcgaccugcuacagcuucgcugucggcuucgcgaugaugugc


agagcaucaacuggcugcgggauggggugcagcugguggagagcaaccguacccgcaucacaggggaggagguggaggug


cgggacuccauccccgcugacucuggccucuacgcuugcgugaccagcagccccucuggcagcgauaccaccuacuucuccg


ucaaugucucagaugcacucccauccucggaagaugaugacgacgacgaugacuccuccucggaggagaaagagacggacaa


caccaaaccaaaccguaggccuguagcucccuacuggacauccccagagaaaauggagaagaaacugcaugcggugcccgcu


gccaagacggugaaguucaagugcccgucgagugggacacccaaccccacucugcgcugguugaaaaauggcaaagaguuu


aagccugaccaccgaauuggaggcuacaagguucgcuaugccaccuggagcaucauaauggauucuguggugccuucugac


aagggcaacuacaccugcaucguggagaaugaguaugggagcaucaaccacaccuaccagcuugacgucguggaacgaucu


ccgcaccgacccauccuucaggcagggcugccugccaacgagacaguggcccugggcagcaauguggaguucauguguaag


guguacagcgauccgcagccucacauucaguggcugaagcacaucgaggugaacgggaguaagaucgggccagacaacuug


ccguauguccagauccugaagacugcuggaguuaauaccaccgacaaggaaauggaggugcuucaucuacggaaugucucc


uuugaggaugcgggggaguauacgugcuuggcggguaacucuaucggacucucccaucacucugcaugguugaccguucu


ggaagcccuggaagagagaccagcugugaugaccucaccgcucuaccuggagaucauuaucuacugcaccggggccuuccu


gaucuccugcauguugggcucugucaucaucuauaagaugaagagcggcaccaagaagagcgacuuccauagccagauggc


ugugcacaagcuggccaagagcaucccucugcgcagacagguaacagugucagcugacuccagugcauccaugaacucugg


gguucuccugguucggcccucacggcucuccuccagcgggacccccaugccggcuggagucuccgaauaugagcucccuga


ggauccccgcugggagcugccacgagacagacuggucuuaggcaaaccacuuggcgagggcugcuucgggcagguggugu


uggcugaggccaucgggcuggauaaggacaaacccaaccgugugaccaaaguggccgugaagauguugaaguccgacgcaa


cggagaaggaccugucggaucugaucucggagauggagaugaugaaaaugauugggaagcacaagaauaucaucaaccuuc


ugggagcgugcacacaggaugguccucuuuaugucauuguggaguacgccuccaaaggcaaccuccgggaguaucuacagg


cccggaggccuccugggcuggaguacugcuauaaccccagccacaaccccgaggaacagcugucuuccaaagaucugguauc


cugugccuaucagguggcucggggcauggaguaucuugccucuaagaaguguauacaccgagaccuggcugcuaggaacg


uccuggugaccgaggauaacguaaugaagaucgcagacuuuggcuuagcucgagacauucaucauaucgacuacuacaaga


aaaccaccaacggccggcugccugugaaguggauggccccugaggcguuguuugaccggaucuacacacaccagagcgaug


uguggucuuuuggagugcucuugugggagaucuucacucuggguggcuccccauaccccggugugccuguggaggaacu


uuucaagcugcugaaggagggucaucgaauggacaagcccaguaacuguaccaaugagcuguacaugaugaugcgggacug


cuggcaugcagugcccucucagagaccuacguucaagcaguugguggaagaccuggaccgcauuguggccuugaccuccag


ccaggaguaucuggaccuguccauaccgcuggaccaguacucacccagcuuucccgacacacggagcuccaccugcuccuca


ggggaggacucugucuucucucaugagccguuaccugaggagcccugucugccucgacaccccacccagcuugccaacagu


ggacucaaacggcgcuga













Fgf1/
 10
auggcugaaggggagaucacaaccuucgcagcccugaccgagagguuca
244


Fibroblast

accugccucuaggaaacuacaaaaagcccaaacugcucuacugcagcaac



growth

gggggccacuucuugaggauccuuccugauggcaccguggaugggaca



factor 1

agggacaggagcgaccagcacauucagcugcagcucagugcggaaagug



M30641

cgggcgaaguguauauaaaggguacggagaccggccaguacuuggccau





ggacaccgaagggcuuuuauacggcucgcagacaccaaaugaggaaugu





cuguuccuggaaaggcuggaagaaaaccauuauaacacuuacaccuccaa





gaagcaugcggagaagaacugguuugugggccucaagaagaacgggagc





uguaagcgcgguccucggacucacuauggccagaaagccaucuuguuuc





ugccccucccggugucuucugacuag






Gpr49/
 64
Sequence below.
245


G protein-
(377)




coupled





receptor 49





FEX





AF110818










auggacaccuccugcguccacaugcuccuguccuugcuggcgcugcugcaguugguggccgccggcagcucaccgggacca


gaugcgauaccgcggggcugcccaucacacugucacugugagcuggauggcaggaugcugcucaggguggacugcucgga


ccuggggcucucggagcugcccuccaaccucagcgucuucaccuccuaccuggaccucaguaugaacaacaucagucagcua


cccgccagucuccuacaucgccucugcuuccuagaagaguuacgucuugcuggaaaugcuuugacacacauucccaaggga


gcguucacgggccuucacagccucaaagugcuuaugcugcagaacaaccagcugagaaagguuccggaggaagcgcuacag


aauuugagaagccuucaaucccugcgccuagaugccaaccacaucagcuacgugccacccagcuguuucagcggccugcacu


cccugaggcaccuguggcuagaugacaaugcucucacagacgucccuguccaggcuuucagaaguuuaucagcccugcaag


ccaugaccuuggcccugaacaaaauacaccacauagcagacuacgccuuuggaaaccucuccagccucgugguucugcaucu


ccauaauaauagaauccacucccugggaaagaaaugcuuugauggacuccacagccuggagacuuuagauuuaaauuauaa


uaaccuugaugaauuccccacugcaaucaagacacucuccaaccuuaaggaacuaggauuccacagcaacaacaucagguca


auaccggagcgagcguucguaggcaacccuucucuuaucacaauacacuucuaugacaaccccauccaauuuguuggagua


ucugcuuuucagcauuugccugaacuaagaacacugacuuugaauggugccucgcacauuacugaauuuccucacuugaca


ggaacugccacccuggagagucugacuuuaacuggagcaaagaucucaucucuuccccaggccgucugugaucaguuaccu


aaucuccaagugcuagauuugucuuacaaccuacucgaagacuuacccaguuugucaggcugccaaaaacuucagaaaauu


gaccugaggcauaacgagaucuaugaaauuaagggcagcacuuuucagcaguuguuuaaccuccgaucucugaacuuagca


uggaauaaaauugcuaucauucaccccaaugcguuuucuacguugccgucucuaauaaaguuggaccuaucauccaaucuc


cugucguccuucccugugacuggguuacaugguuuaacucacuuaaaauuaacagggaaccgagccuuacagagccugaua


ccaucugcaaacuucccagagcucaagauuauagaaaugccaucugcuuaccaguguugugcauuuggggggugugagaau


gucuauaaaauuucuaaccaauggaauaaagacgacggcaacaguguggacgaccuucauaagaaagacgcuggguuauuu


caaguucaagaugagcgggaccuugaagauuuccuacuugacuuugaggaagaccugaaugcccuucacucggugcagugc


ucgccuuccccaggucccuucaagcccugugagcaccuauuugguagcuggcugauccgaaucgggguguggaccacggca


guacugacgcuuuccugcaaugccuugguggcuuugaccguguucagaacuccccuguacaucucuuccauaaagcugcua


auugggguaaucgcgguaguggacauucucaugggggucuccagugcugugcuggcugccguggaugcauucacuuuug


gccguuuugcucagcacggugcguggugggaagacggaaucggcugccaaaucguuggcuuccuguccauuuuugcuucc


gaaucgucgaucuuccugcucacucuggcagcgcuggaacgagguuuuucugucaagugcucuucgaaguuugaagugaa


agcuccccuuuuuagccugagagcgaucguuuugcuauguguccuguuggcccugaccauugccacaauccccuugcuag


gaggcaguaaguacaaugccucuccccucugccugcccuugcccuuuggggagcccagcaccacgggcuacaugguggcuc


ucguguugcucaacucucucuguuuccucauaaugaccauugccuacacaaagcucuacugcaguuuggagaaaggagagc


uggagaaucuuugggauuguucgauggugaagcacauugcucuguugcucuucgccaacugcauccuuuacugccccgug


gcuuucuuauccuucuccucuuugcuaaaccucaccuuuaucaguccugacgucauuaaauuuauacuucucgugaucguc


ccacuuccuuccugucucaacccacuucucuacauugucuucaauccccauuuuaaggaggauaugggcagccugggaaag


cauacccguuucuggaugagaucaaaacacgcgagucugcuguccauuaacucggacgauguugagaaacgguccugugag


ucaacccaagccuuaguauccuuuacccacgccagcauagccuaugacuugccuuccacuuccggggcaucaccagcuuacc


ccaugacugaaagcugucaucucucuucaguugcauuugucccaugucucuagugacuaugagagaggaacguuuuuaag


aguuggaaaccugaaaagugauuucuaucagagcaguagcuaagaaaagcugagcuaaaaaccuaccuuaaaacccaagcaa


acaucucuaaauugguguggaaacaguggugccuuagagcaggagagcaucauuaaacaccgcuuguaucauuuguucagc


uaagaaggaaagccaucaagucacuuaggugaacccagaugagaaaagcagccugaaaugcucuucgcauuguagucucuu


cugacucaccagcauagucucccauagugagaagacucguuggaugacucaauggguguauuuaaauccacaaauuccuug


uuuaaaagguuagaguuuuaagaaaaaaaaaaaaaaaaa













Igfbp5/
 37
Sequence below.
246


insulin-like





growth





factor





binding





protein 5





L12447










uuuuuuuucuucaccuccucccuuuucaaggccuccaagcuaauuauuucuguugcuuuggagugagcaauucugugguu


cucuccaccaccacccccaauucugacccgaucccgccuggggguuucuacggucuccgcucacucugcgugcaccuggcgc


gccucuuuuuuucacccccaaccuguugcaagucuuuaauccucgcaauugggacuugcgugcaggcaccugaauccuccu


ugccucauauuuugcaaguguuugggggagagcaccugcucuaccugcaagagauuuaaaaggaaaaaaaucuccaggcuc


ccucuuucuccacacacucucgcucuccugccccgccccgagguaaagccagacuccgagaaaauggugaucagcguggucc


uccugcugcuggccgccuaugccguaccggcucaaggccuggguucuuucgugcauugugaacccugcgacgagaaagcuc


uguccauguguccccccagcccucugggcugugagcuggucaaagagcccggcuguggcugcugcaugacuugcgcccug


gcggagggacagucguguggugucuacacagagcgcugcgcccaggguuugcgcugccucccccggcaggaugaggagaa


gccgcugcacgcccugcugcacggccgcgggguuugccucaacgaaaagagcuacggcgagcaaaccaagauagagagagac


ucucgggaacacgaggaacccaccaccuccgagauggcugaagagaccuacucccccaaggucuuccggcccaagcacacuc


gcauuuccgagcugaaggcugaggcugugaagaaggaccgcagaaagaagcugacccaguccaaguuuguggggggugca


gagaacacugcccaccccagagucaucccugcaccugagaugagacaggaauccgaacaaggccccugccgcagacacaugg


aagcuucccuccaggaguucaaagccagcccacgcauggugccccgugcuguguaccugcccaacugugaccgcaaaggau


ucuacaagagaaagcaguguaagcccucccguggccgcaaacguggcaucugcugguguguggacaaguacggaaugaagc


ugccgggcauggaguacguggauggggacuuucagugccacgccuucgacagcaguaacguugagugacgcguccccuccc


uuccucccccuauccuacccccccagccccaacuccagccagcgccucccuccaccccaggacgucacucauuucaucucauu


uaggggaaauauauauacauauauauuugaggaaacugaggaccucggaaucucuagcaagggcuaaggagacacucccca


ccaugaccccggaaauguauuccuuuuugaagcaaguugaacggacagagaagggaaggagagaagaagcaagagggagcg


agagauggaaagaaagcaaagcguuggaauagaggaaaagagggaaggacagauaggauuagagagagaagagagaaacag


caaggcagaaaggacuccacaaccaaggcugaaucugcccuuuugcuuucagcucuagccuggggucagaaaaaguguggc


auucagugacacccaguuuagauuggucaaggggagaaaagaaacaaggugugucagugccucucgggucuguccccuccu


gcagccagcaguguggauggcuagaccccucacccuccucuccucuuacccaagugcagggugauuucauccccaaauuua


caaagacuaaaaugcauuccaucccucugaaaauaaacaaaagugagugauugaagauagguuuucccccagcagacaagug


aacucagaaugugugcaaauuuuacucuuguuaaagauuuuuuuaagaagucaguacgcacccccaacacuggaaagacuu


gauucuccagggugacaagcaauucagaagcgcguggcuucggcccuugauuucacuagacucaaagcuggcccggcagcc


ucuguggaggaggaugagagguggagaaaaccaaggggcuuguacucacccacaagacuccauguagacuuuauaggcaua


uaaaucuauuuucuuuaccuuuuuuucccuuucccuuucuuucgaaguuuugcauuaccucuuuaaaguaguuuuuuuua


ggacacugaagaucuuccucauucugggaaaaauccauauuucacaaauacaacccagaacgccagcuuggccugcguccag


gcagccuuucucgugagcuacaaguguggcucuuuuguggggcaccgauuuggaucuucucaugauuccaaacguguguu


gaagugaauccaccaagccagguaacugccagcacccaagggugcaucaagugcauagcccaggucaccccauuucagccuu


ccaacccgcagaaaguaacugucucacaccacaccacauaaaccugccagauccaucuguaacccacuggccugcccagaccu


uuuuuucccaucugcauuuuuuuuuuugaacugcauuuugaaagccucccucagaugccaggcugacagaucagagagaaa


cuaacaugagagaugacagaggaggaggaaguggagggugggggcagagacuuccacagagagacauagaagauggagcag


aggucuggggguggggaggacaagaaagagacagagagaggaaaauaccaauagaauuuuccuuggugucucccaucuaau


caacucucugagauuugagaggaaaaagaaggcaggggaagaacuugagguagaaaugaggucaguucaagucacagggcc


cagaugguggguaacugaggcaggauccagacuugagacacacgguuggaaacaaggcugguuagccugacuggguauug


aagggugaagaggaugccuuggaaagacagcacaacuucaguucaacuucaggcccccaaggaggaacugaggccaaagaau


ccuucaagugcuucaugagucuccucugcccgacucaaacauccuucccugugauggaggaugguagaaagcccaggacaa


cucaggcccggaucuucacgacuguugucauuugccagccugauuuugauccaagagaagcaucucauugcccacuggcuu


cuucaacaaagaggugcuuaacaaaaggcucaggacuaucuuugaagacugaagauaaccuuccaggagaggagacucgga


cauugguacaggaggccccuuuuggcgggggacacagcucuuugcgcucucuugauggcauggcauaguagaggcccccu


ccaacccggaacauggagcaacacaaagggagagcaaagaaacugacgugcgucgacucauaggacauggguggcugcggg


cacagaaagggaugccuccuguugccuggacaggacaguuggcugggaaggaaagagaaaauugaucuucauaagacaaag


ggccugaugggauggcaauagaaggacuuaccagaccugcagggucaguauacccaucaccccgcacaacauccccagcccc


caacucaaacuucaauauaucuuaggccaguauccuagaccuaagucucuccuuucugccauuauuucuccgcaucuugag


cagucaucugacugagauuugccaaguggauacugggguaccacugccccccaagaaaagacugagccaggaacugccuac


ucgcucccccucccgagccuggagcuaacuccugugaggggugcucucuucaccccacaacuuacuagaccuugagugagc


cucugucccuuaugugggcucuucgcugugagccacagauggaggucauuguauagacaguuagccuuccccaggucagc


cuaccucccccaaacuugugagucuccccgcugcucauauggagaggcaugucuaagacagcaagucuucuagaggaagcu


ugccuuuaacagacagauggaacuaaaccuuccaaaugggagaucuggcugaacccaggauacagagaccauggacaugga


uggggucaucaagagaagagggauguccuucuccagguuagggagagagaaggcaaguuugcaacgaucccaucaugcccu


gagcaagaagcuuuuggcccaggcuagccuuuaacuccauuagaggccucucuguuggguuuauccacagcaguaggccca


aguauggccuguccccaccucuacuaucccguggaagguuucuucccaccccuuuuugacaaaugccucacucgagcagug


gaaagauagcucucuucccccucuucugccagguaacaaagagaccuaaccaggaccuauucuccaccccagccagucuuga


ccagccagaacaaagcagggaaccuggagaauaaaagacucuacguuccucugacaaagacucuacguuucucugacggcca


ggccuaaacagacaaggcuugggaacaucugccccacaggauacggaggaggucagcugugcucacuccucuucuccuucc


aagacccucuuccgaccaugacuuaucuccaugguaacauccucaccaucauucucccacuaccaaggguugccauggcaac


cucccaaccaccugcccaucccaggcaggcagcuguccuucugcucagaacccuagaggacucuaggugaaauuuuacagcu


uaagagaggagugagccaaggagaagagacccuguaguccucuggcuuucaagagaaagaaggcuaugauuuaaaacacag


uagaagggaaagaggucucgucgaggucgaccucucccggggagcuuagggguuguacugucuuuauuuuuuaaaccacu


aaagugcaaunuuuccugcacucuuguuaccccgccucucuucccuguuagguuuucauuuccuugagcagacuuucuug


guuuuuuaauggaguauagacuuucaccacuucacagacucuggccuccucuccaagucucucuggauggggaaaaggaag


guagagggucagaggggaaggggucccucgucaccccgcauccauucacccccacuucucuggucccuagucaccggcuuc


accccnaucuccgacaccaucacugucacacaguagccugucacacggauaguacaguucagacaagacuccuucagauucc


gagacgccuaccgguuguuuuugguuuuuguuuuguuuucuuuuguuuguuuguuuguuuguuuuuuacaacagcaau


aaccacaucacauauuacuguagcucucuauaguguuacguucagacaccguagcucuguccucucuuauuuuguugguu


uugacuuaaaaaaaaauacuuaugcuuuuuacuggugaaacagauugaaaaaaaaauugaacaacaaaccaguuugugaaaa


aaaaaaaaaaugugaaaaaaaaucaccccgauguggaagagcucggcuccucuuuagcauuuuguacuuaaggaaauaaaaa


agaaaaaccuggaagaucucacauuuuauuacaaagugaaaaaaaaa













Myoc/
111
Sequence below.
247


trabecular





meshwork





induced





gluco-





corticoid





protein





AF041335










guccagucugcagucuguauucggaagacauagauacuaaauacauggcaacucuuuuuuuuguuuguuuuaauucauca


ggauguggagcgcuagucuggguaggagagccagucacccugaggacagcugaaacaaucgcuggcaaguauggagugug


gaugagagaccccaagcccacccaccccuacacccaggaaagcacauggaggauugacacgguuggcacagagauccgccag


guguuugaguacagucagauaagccaguucgagcagggcuauccuuccaagguccaugugcucccucgggcacuggagagc


acgggugcugugguguaugcggggagccucuauuuccagggggcugaguccagaacuguggucagguaugagcuagacac


ggagaccgugaaggcagagaaggaaauuccuggagcuggcuaccacggacacuucccguacgcgugggguggcuacacaga


cauugacuuagcuguggaugagagcggccucugggucaucuacagcacggaggaagccaagggggccauaguccucuccaa


auugaacccagcgaaccuggaacuugagcguaccugggagacuaacauccguaagcagucuguggccaaugccuuuguuau


cuguggcaucuuguacacggugagcagcuacucuucagcccaugcaaccgucaacuucgccuacgacacuaaaacggggacc


aguaagacccugaccaucccauucacgaaucgcuacaaguacagcaguaugauugacuacaacccccuggagaggaagcugu


uugccugggacaacuucaacauggucaccuaugauaucaagcucuuggagaugugaggagccucuaugccuaccagcaaag


gccagaaaaggugaaguuccgggcucccgggugaagcagcugucagcagaggcagccagaugcauggaguuucuccuccug


cuaaagauuuuguuuauccgggucaauguacagcuagcuccccucugacugacacguccuccaggcuuguauagucgcaua


gacucuguucucuucugucagcuuucaaagggcuguuccucuuuuaaaaaucacauagug













Itm2a/E25
 30
Sequence below.
248


putative





Integral





membrane





protein 2A





L38971










gggagaccugagcucgcugcugccuguggaagacugggagaggagacacuaagugcugcucaagcaagcgcgauccucucc


ucuuucaaccugcagcccaagauacugauucgagccgcgccuuaccgcgcagcccgaagauucaccauggugaagaucgccu


ucaacaccccuacggcggugcaaaaggaggaggcgcggcaagauauagaggcgcucgucagucgcacuguccgagcucaaa


uccugacuggcaaggagcucagaguugucccgcaggagaaagauggcucaucugggagaugcaugcuuacucuccuaggcc


ucucauucaucuuggcaggacugauuguugguggagccugcauuuacaaguacuucaugcccaagagcaccauuuaccaug


gugagaugugcuucuuugauucugaggauccugucaauuccauuccuggaggagagccauacuuucugccugugacugag


gaggcugauauccgugaggaugacaacauugccaucauugaugugccugugcccaguuucucugauagcgauccggcggc


aauuauucacgacuuugagaagggaaugacugcuuaccuggacuugcuuuugggaaacuguuaucugaugccccucaauac


uuccauuguuaugacuccaaagaaucugguggaacuuuuuggaaaacuggcaaguggcaaguauuugccucauacuuaug


ugguucgugaagaccugguugcuguggaagaaauucgugauguuaguaaccuugguauuuuuauuuaccaacuuugcaac


aaccgaaaauccuuccgccuuagacgcagagaccuucugcuggguuucaacaagcgugccauugacaaaugcuggaagauu


agacacuuccccaaugaauuuaucguugaaaccaagaucugucaggagugaaaugugacagauaaagaguauccuugauaa


uaagaagucaggaacuuaccgucugacuuggaaaauugaaauugaugggauacucaugcuauuuacucauacauuuacucu


auugcuuauacuggaaaaggaaagggaaaggggggagaaaacuacuaaccacugcaagcgauuguccaauucuacuuuaau


ugacauugcuugcuguuuucaacaagucaaaugauuaucuuuucucuugaauuuauaggguuuagauuucugaaagcagc


augaaugugucaucuuaccauccugacaauaaagcccauccucugguuuuauuuaaagcaagcucuuuccaacaucacuug


gcuagagcaugcuuuaaauuuaaaauauuugaaauuuguuuuugacauuuuuuugugugaaacaugucaaaucucuuacc


auucuuugguuuucuucuuuauuauguucaacucuccugauuucagaaguuacauuuuugcauuucuaucaggugcugu


guaacgaaucugacugauaugugaacaaucuucaugaggaagcaauuuuuuacucauguaaugauucuuucucacugauau


cuguauugugaaauccacagaacuguacaggugcugaaugcuguaaggaguucugguuguaugaauucuacaacccuauaa


uaaaguuuaccguauucaauca













Eps8/
 15
Sequence below.
249


epidermal





growth





factor





receptor





pathway





substrate 8





L21671










ggccauuaccaaucgcgacccgcgcacacacggcccgggcggcgggcgaagcgggcucccggggcgcugggcgcagggcgc


ggggcaagccccagcagcgugucugcaacggggcgcggcgggcgcuccagcuccgggaucuuucucccucggucaccuccc


ucgcgucuagggaggucguggcacucccugaggagcgcggcugcucggagggcggauccuagaacagaggcgugagagcc


ggcaugaauggucauaugucuaaccgcuccaguggguauggagucuacccuucucaacugaaugguuacggaucuucacca


cccuauucccagauggacagagaacacagcucaagaacaagugcaaaggcccuuuaugaacaaaggaagaacuaugcccgag


acagugucagcagugugucggacgugucccaguaccgcguggaacacuugaccaccuucgugcuggaucggaaagaugcaa


ugaucacugucgaggacggaauaagaaagcugaaguugcuggaugccaagggcaaaguguggacucaagauaugauucucc


aaguggaugaccgagcugugagccugauugacuuagagucaaagaaugaauuggagaauuuuccucuaaacacaaucucgc


auugucaagcaguggugcaugcaugcagcuaugacuccauucucgccuugguaugcaaagagccaacgcagagcaagccag


accuucaccuuuuccagugugaugagguuaaggcaaaccuaauuagugaagauaucgaaagugcaaucagugacaguaaag


gugggaaacagaagaggcggccggaggcccugaggaugauugccaaagcagauccuggcaucccuccuccucccagagcuc


cugccccugugccaccggggacugucacacagguggacguuaggagucgcguagcagccuggucugccugggcagcugacc


agggugacuucgagaagccccggcaguaccacgagcaagaagagacgcccgagaugauggcagcccggaucgacagggaug


ugcaaaucuuaaaccauauuuuggaugacauugaauuuuuuaucaccaaacuccaaaaagccgccgaagcguuuucugagc


uuucuaaaaggaagaaaaguaagaaaaguaaaaggaaaggaccuggagagggcguuuuaacacugagggcaaaaccgccacc


uccugacgaguuuguugacuguuuccagaaguuuaaacauggauucaaccuucuggccaaguugaagucccauauccagaa


cccgagugcuucagaucugguucauuuuuuguuuacuccacuaaauauggugguccaggcaacagguggcccugaacugg


ccaguucgguacucagcccacuguugacaaaagacacaguugauuucuuaaacuacacagccacugcggaggaacggaagcu


guggaugucacugggagauaguugggugaaagugagagcagaguggccgaaagaacaguucaucccaccuuacgucccgag


guuccgcaacggcugggagcccccgaugcugaacuucaugggcgcgcccacagagcaagacauguaucaacuggccgaguc


cguggccaacgcagaacaccagcgcaaacaggacagcaagaggcuguccacagagcauuccaauguguccgacuauccucca


gccgacggauaugcguacaguagcagcauguaccacagaggaccacaugcagaccacggggaggcugccaugccuuucaag


ucaacuccuaaucaccaaguagauaggaauuaugacgcagucaaaacacaacccaagaaauacgccaaauccaaguacgacuu


uguggcgaggaacagcagcgagcucucgguuaugaaagaugaugucuuagagauacucgacgaucgaaggcaguggugga


aaguccggaaugccaguggagacucuggguuugugccaaauaacauucuggauaucaugagaacuccagaaucuggagugg


ggcgcgcugaccccccauacacacauaccauacagaaacaaaggacggaauacggccugagaucagcugacacuccuucugc


cccaucacccccuccaacgccagcacccguuccggucccccuuccaccuucuguaccagcacccguuucugugcccaagguu


ccagcagaugucacccgccagaacagcagcuccagugacagugggggcagcauugugcgggacagccagagauacaaacaac


ucccaguggaccgaaggaagucccagauggaagagguucaggaugagcucuuccagaggcugaccaucgggcgcagugcug


cgcagaggaaguuccacgugccacggcagaacguuccagugaucaauaucacuuaugacuccucaccggaagaaguaaagac


uuggcugcagucaaagggauucaaucccgugacugucaauagccucgggguguugaacggagcacaacucuuuucucucaa


caaagacgaacugaggucugucugcccggaaggugccagagucuuuaaccaaaucacuguucagaaagcugcuuuggagga


caguaauggaagcuccgaguuacaagagaucaugcggagacggcaggagaagaucagcgccgcugcgagcgacucgggagu


ggagucuuuugaugaagggagcagccacugaguccaugaacuuccuuauucuugguguggucguugaacagugauggaca


ugcuuuguuuuaagaagccuugaagggaaugucaaagcugucgucuugguauauguaauuuaucgccauauaaggaaaca


guauaugccugaguaagcagaggacccgcugcuucugugcacauuaguuugauuaaaacugagaagcggguaggugagau


ggcucagcaaguaaaggugcuugcugccaagcccaaugacccaaguucgagucccugggucuacaugguaggagagagcug


gcuucugcaaguuguccucugaccaccacacauaaauaaauaacaaauguaauuuacaaacuuuuaaaagaaaauguaauuu


aaaaaaccagacguucuagacuguucugggcuugggaaauauuuuuuucacuuuccuaagguguacuuuccuuugcuaca


uuaauuauugcagccuuguucgaugaucuaaguggggauauuugacaauggcagauuuauucauugcaacaaggaaagac


acagccauugaugaaaaaaaaaagaaagucucagcuuucagugacugggauaccugcuguccagggaggaggcucaguuag


acuacccucugcuuacuugaggucugacaugcccaaugagaguguauuuagcuuuauuuaaaguucuuaaugccaacaguu


uuaaaaaucacauuuaaaugaacuguacaagguagccagaccuugaauguaugaauagacuauauaauaugucccgagaaac


uuuguuacucucagcucuguugauugcgaaaucuugcauagauuaugcuuugauuuaguuucu













Fyn/Fyn
 10
Sequence below.
250


proto-





oncogene





M27266










ccugggccccgccgcggacgcgcggagccgccugggccgcgccggaggagggcggggagaggaccaugugaaugugcucc


ggagcugagcgccaagccaagcaguguuugaaaggaacaggaugcugaucuaaucguggcaaaaagucaguccgaccgcug


guuucgaagacaugugguguauauaaaguuugugauaguugguggaaauuugggagcuuggauaaugggcugugugcaa


uguaaggauaaagaagcagcgaaacugacagaggagagggacggcagccugaaccagagcucuggguaccgcuauggcaca


gaccccaccccucagcacuaccccagcuucggcgugaccuccaucccgaacuacaacaacuuccacgcagcugggggccagg


gacucaccgucuuugggggugugaacuccuccucucacacugggacccuacgcacgagaggagggacaggagugacacugu


uuguggcgcuuuaugacuaugaagcacggacggaagaugaccugaguuuucacaaaggagaaaaauuucaaauauugaaca


gcucggaaggagauuggugggaagcccgcuccuugacaaccggggaaacugguuacauucccagcaauuacguggcuccag


uugacuccauccaggcagaagagugguacuuuggaaaacuuggccgcaaagaugcugagagacagcuccuguccuuuggaa


acccaagagguaccuuucuuauccgcgagagccaaaccaccaaaggugccuacucacuuuccauccgugauugggaugaua


ugaaaggggaccacgucaaacauuauaaaauccgcaagcuugacaaugguggauacuauaucacaacgcgggcccaguuug


aaacacuucagcaacugguacagcauuacucagagaaagcugaugguuuguguuuuaacuuaacugugguuucaucaaguu


guaccccacaaacuucuggauuggcuaaagaugcuugggaaguugcacgugacucguuguuucuggagaagaagcugggg


cagggguguuucgcugaaguguggcuugguaccuggaauggaaauacaaaaguagccauaaagacccuuaagccaggcacc


augucuccggaguccuuccuggaggaggcgcagaucaugaagaagcugaagcaugacaagcuggugcagcucuacgcgguc


gugucugaggagcccauuuacaucgucacggaguacaugagcaaaggaaguuugcuugacuucuuaaaagauggugaagg


aagagcucugaaguugccaaaccuuguggacauggcggcacagguugcugcaggaauggcuuacaucgagcgcaugaauua


uauccacagagaucugcgaucagcaaacauucuaguggggaauggacuaauuugcaagauugcugacuuuggauuggcuc


gguugauugaagacaaugaauacacagcaagacaaggugcgaaguuucccauuaaguggacagcccccgaagcggcccugu


auggaagguucacaaucaagucugacguauggucuuuuggaaucuuacucacagagcuggucaccaaaggaagagugccau


acccaggcaugaacaaccgggaggugcuggagcagguggagagaggcuauaggaugcccugcccacaggacugcccgaucu


cccugcacgagcucaugauccacugcuggaaaaaggauccggaagagcgcccgaccuucgaguacuugcagggcuuccugg


aggacuacuuuacggccacagagccccaguaucagcccggugaaaaccugugagagccugcgcuucagacgccucuucccga


ggccucccuaccccuccccauuagcuuccaauucuguagccagcugccccagagcaggagaaccguccaggaucagauugca


ugugacucuugaagcugaacuuccacggcccucauuaaugacacuugucccccaguccgaaccuccucugugaaccaucug


agacagaagcguguuauuucucagacuuggaaaugcauuguaucgauguuaugucaaaggccaaaccucuguucaguguaa


auagcugcuccugugccaacaaucccagugcuuuccuuuuuuaaaaaagaaaaagcaaauccuaugugauuuuaacucuga


uuucaccugauucaacuaaaaaaaaaaaaguauuauuuuccaaaaguggccucuuugucuaaaacaauaaaauuuuuuuuc


auguuuuaacaaaaaaaaaaaaaaaaaaaaaaaa





Structurally-related










Col6a1/
 36
Sequence below.
251


Procol-





lagen, type





VI, alpha 1





X66405










cccucccuggcucucuccucagcucugggcucugacugcagcaagcagagacaaccucucacucugccuuucccagcgccca


cccugacccuggcccacauuugacggugacucgcaggccagccagaaacaugaggcuggcccacgcucugcugccccugcu


gcuacaagccugcuggguggccacacaggacauccagggcuccaaagcgauugccuuccaagacugcccuguggaucuauu


cuucgugcucgacaccucggagaguguggccuugaggcugaaaccuuauggggccuugguggacaaggugaaguccuuca


cuaagcgcuucauugacaaccugagagacagguacuaccggugugaccgcaaccugguuuggaaugcgggugcgcugcacu


acagugacgagguggagaucauccgagggcucacgcgcaugcccaguggccgcgaugagcucaaggccagcguggaugcgg


ucaaguacuucgggaaaggcaccuacaccgacugcgccauuaagaaggggcuggaggagcugcucauagggggcucccacc


ugaaggagaacaaguacuugaucguggugaccgacgggcauccucuagagggcuacaaggaaccaugcgggggucuggaag


augcaguaaaugaggccaaacaccugggcaucaaggucuuuucuguggccaucacaccugaccaccuggagccacgucuaa


guaucauugccacagaccacacauaccggcgcaauuucacggcagcugacugggggcauagccgcgaugcagaagagguca


ucagccagaccauugacaccauuguggacaugauuaaaaauaacguggaacaaguguguuguucuuuugagugccaggcug


ccagaggaccuccagggccccgaggcgacccuggguaugagggggagcgaggaaagccaggucuuccgggagagaagggag


aagcuggagacccuggacgaccuggggaucuuggaccagucggguaccaggguaugaagggagaaaaggggagccgugga


gagaaggguuccagaggaccgaaagguuacaagggcgagaaaggcaagcgcggaaucgacggggucgacggcaugaaggga


gagacgggguacccaggacuaccgggcugcaagggcuccccaggauuugauggcauucaaggacccccgggucccaagggu


gaugcuggugccuuugggaugaagggagaaaagggugaagcuggagcagacggugaggcugggagaccagggaacucagg


gucaccuggagaugagggugauccuggagagccugguccccccggagaaaaaggagaggccggugaugaaggaaaugcug


gcccagacggugccccuggagagagggguggcccuggugaaagaggaccucgggggaccccuggugugagaggaccaagg


ggagacccgggugaagcuggaccacagggugaccaaggaagagaggggcccgucggcaucccuggagacucgggugaggcu


ggccccauuggaccuaaaggauaccgaggugaugaggguccuccagguccugagggccucagaggagccccaggaccuguu


gguccuccuggagaccccggacugaugggugagagaggugaggauggaccaccaggaaacggcacggaagguuuccccggc


uucccuggguauccaggcaacagaggcccuccugggcuaaauggcacaaaaggcuacccuggccucaagggggaugagggu


gaagugggagacccaggagaggauaacaacgacauuucaccccguggggucaaaggggcaaagggauaccgaggcccagaa


ggaccccagggaccuccaggacaugugggaccaccugggccagaugagugugagauccuggauaucaucaugaaaaugugc


uccugcugugagugcacauguggacccauugacauccucuucgugcuggacagcucggagagcauuggccuacagaacuuu


gagauugccaaggacuucaucaucaaggucauugaccgguugagcaaggaugagcuggucaaauuugagccagggcagucu


cacgcgggcgugguacaguacagccacaaccagaugcaagagcacguggacaugcggagccccaacguccgcaacgcccagg


acuucaaagaagcugucaagaagcuacaauggauggcugguggcacauucaccggagaagcgcugcaguacacccgggacc


ggcuacucccacccacacagaacaaccgaauugcccuggucauuacggauggacguucugacacucaacgggacacgacacc


ucucagugugcucuguggugcagacauucagguaguuucugugggaaucaaggauguguuuggcuuuguggcgggcucc


gaccagcucaaugucauuuccugccaaggcuuaucgcaaggucguccagguaucucccuggugaaggagaacuaugcagag


cuucucgaugacggcuuucugaagaacauaacagcccagaucuguauagauaagaaguguccggauuauaccuguccaauc


acauucuccuccccggcugacaucaccauccugcuagacagcucagccagugucggcagccacaacuucgaaaccaccaagg


ucuucgccaagcgccuagcugagcgauuccugucagcaggcagggcggauccuucccaggaugugcggguggccguggua


caguauaguggccaggggcagcaacagccaggucgggcggcucuucaguucuuacagaauuacacagugcuggccagcucu


guggacagcauggauuucaucaacgacgccacagacgucaacgaugcucugagcuacgugacucguuucuaccgggaagcc


ucgucaggugccaccaagaagagagugcuguuguuuucagacggcaacucucagggggccacagcagaggccauugagaag


gcugugcaggaggcccagcgugcaggcauugagaucuuuguggugguggugggaccccaggugaacgagccccacauccg


ugugcuugucacuggcaagacugcagaguacgacguggccuuuggcgagcgccaccuauuccguguaccaaacuaccaggc


ccugcuacguggcguacucuaccagacagucuccaggaagguggcacugggcuagagggccacacacguggcuggacacac


auggcauggagacacauuucaacaggccuucccgcccuucccacugacaaaacaggaauaggaaaugugacccaacugguca


acucaacugucuuaaagggaacgcugagaugcacacucuuugcuuuguguaauguccccuguggcucaccugagcuccuau


cuagaucccgcccuugguuuguacaucaugguggccaucuugcugaccccucccccaucugggacuggauccagccaucuc


gucuuccuccucacugccccuaaccuauccguggugucuucacaccaucacugcaguuuccgucuguguucugucuuccau


gcucaacaugaagcagaccuucucaugaguucagcuugcuggauuauggcuuuuaggaaauugaacacaggaggaguucca


aacacaaacuuggaggagaccccuccucuucaucaggugcuugucagugaccuacaugcaucuuggucugguccuuagugg


cuaguccuuccacucugaaagcaaaggugcuaucuaucuguaagggcucucucuacacacccagaggcuuagcuuggacag


uucacacucaaguguccugucagaaucaauccagagcuuucucccucaaaauagugacuugucucccccugguccccaaagg


cuccccuuuaguuaguuucuucauggcucccccacauuccccguaaucugauccaagccagcuaucucugcuaauaaaggu


uuccauuuuucaaaaaaaaaaaaaa













Tnc/
 17
accccaugccccacccccaccuucgauguuuugaacauuucuaacaacug
252


Tenascin C

aagccaguaaagucauauucuuuaaauuuccaggacauucauauuauuc



AV230686

acauaaucauggucauggugaugauggaaacugaggacuuuaaaagaga



X56304

uuuucccuucccaaacguuucuggacaguaccugauuguauuuuuuuu





guuuuguuuuguuuuuuaauaaaagcacaguacuuuucc






Krt2-6a/
 10
Sequence below.
253


Keratin





complex 2,





basic, gene





6a (keratin





6a)





K02108










gucugcccugccguuucucuacuucccagccuucucaucuccaggaaccaugucuaccaaaaccaccaucaaaagucaaacc


agccaccguggcuacagugccagcucagccagagugcuuggacucaaccgcucgggcuucagcaguguguccgugugccgc


ucccggggcagcgguggcuccagugcaauguguggaggagcuggcuuuggcagcaggagccucuaugguguggggagcuc


caagaggaucuccaucggagggggcagcuguggcauuggaggaggcuauggcagccgauucggaggaagcuucggcauug


gugguggagcugguaguggcuuuggcuucggugguggagcuggcuuuggugguggcuaugggggagcuggcuucccgg


ugugcccacuuggaggcauccaagaggucaccaucaaccagagccuccucacaccccugaaccugcaaauugaccccaccau


ccagcgggucaggacugaggagagggagcagaucaagacccucaauaacaaguuugccuccuucaucgacaaggugcgguu


cauggagcagcagaacaaggucauggacaccaagugggcccugcugcaagagcaggacaccaagaccgugaggcagaacaug


gagcccauguuugagcaguacaucagcaaccuccgcagacagcuggacagcaucauuggagagaggggucgcaugaacuca


gagcugaggaacaugcaggaacucguagaagaacuacggaacaaauaugaagaugaaaucaacaagcgcacagacgcagaga


augaauucgugacccugaagaaggauguagaugcugccuacaugaacaaaguugaacugcaagccaaggcagacagucuaa


cagaugauaucaacuucuugagagcucucuaugaagcagaacugucucagaugcaaacucacaucucagacacaucugugg


uccucuccauggucaacaaccguagccucguccuagacagcaucaucgcugaggucaaggcccaguuugaggucauagcuc


agagaagucgggcugaagcugagucauuguaccagacuaaauaugaggagcugcaggucacagcuggcagacauggggacg


accugcgcaacaccaagcaggagauugcugagaucaaccgcaugauccagaggcugagaucugagaucgaccacguuaagaa


gcagugugccaaccugcaagcugcuauugcugaugcugagcaacguggggagauggcccugaaggaugcaaggggcaagc


uggaagggcuggaggaugcccugcagaaggccaaacaggacauggccaugcugcugaaggaguaccaugaacucaugaaug


ucaagcuggcccuugauguggaaauugccaccuacaggaagcugcuggaaggagaggagugcagguugaauggugaaggu


guuggaccagucaacaucucuguggugcaguccaccguguccagcggcuauggcagugccgggggugccagcagcagcuu


aggcauggguggaggcagcagcuacuccuauagcagcagccauggccuuggagguggcuucagugcuggcaguggcagag


ccaucggagguggccucagcucuucugguggccucagcucuucuaccaucaaauacaccaccaccuccuccagcaagaagag


cuacaggcagugaauucugucaccaagagcuugucucuggucccagaugucauggcugcagcugaaccacaugcuuugguu


cccggaagggaacgaaucccaaccucuggccuccccauggcucaguucuacauuuguguugcacgucagcaccuauacaug


uucuuuggugacccagaccccaaaauguugcagaauguagaccuccaagacgaaaccccaaacccuacccagaauacccaccu


aaauucugucaugguucugacuuccuccagagucuguaaaauaaaaugcccccacaacaaac





Channel-related










Potassium
 14
uuuuuuuuuuuuuuuuugauuuuaauuacaaacuuuauuuguccuc
254


channel,

caguucacaguuuauacgugguacaucccaccaugucagcuuccaga



subfamily

acggcuauucaggagauggguggagcuuucuuuguaaaggaacccga



K, member

cauuuuaaaauuuugguuagaaucuucauagguuuauaaaaguacuc



2

ucugcaagcgaacuggauauauuuacauuuauagcuuaaauucaaau



AI849601

uuuggaaaauaggaaucuuuuuguguuuuuaaacauccuggguuua





ugucuuaagacuuuacucugaaugccacaugaucacguaagcccaag





ccucccccagaagggaaaaaucaguuuugc






Skd3/
  4
uuuuuuuuuuuuuuuuugggugccaugccacagcaaggggccuuua
255


Suppressor

uuagauguucagggcacagacagguggaugcuagaugguguagcaca



of K+

ccuucucaggguggaguggugccuggauguccaguuugcgggucuu



transport

gcuguccuuaucaaugaucuccagucgcaauguagguggacgcuucu



defect 3

cagccuggggugagggcagcucacggcucuugaggaggugcuuguc



AI837887

cgaauccuccacagugauacccagggugcaacccccugg






Clic4/
  3
uuuuuuuuuuuuuuucugacacaguaguaauccuuccagacuccuu
256


Chloride

acacaauauuacaacucccccaguacauaaauguuccuauaccaugca



intracellular

cacagcaacaugggguccacugaugucgcaggcgacuuuucuaaugg



channel 4

uggaacauagcaccucaaguucugccaucuacacagugaagggacgu



(mito-

gauggucggggcuccagagugacagcaaacugccucuugggugacac



chondrial)

gcuuguggcgaagugccucc



AI845237








Col18a1/
  5
Sequence below.
257


Endostatin





(alpha





1(XVIII)





collagen)





L22545










gagaauguugcugaggagguggggcugcugcagcuccuuggagacccccuaccugagaagaucucacaaaucgaugacccu


cacgucgggccggccuacaucuuuggaccagacuccaacaguggccagguggcccaguaucauuucccaaaacucuucuuc


cgggacuuuucgcugcuguuucauguccggccagccacagaggcagcaggggugcuauuugccaucacagaugcugcccag


gugguagucucacugggcgugaagcucucagagguccgagauggacagcaaaacaucucauugcucuacacggagccuggg


gccagccagacccagacgggagccagcuuccgccuaccugcauuuguugggcaguggacacacuucgcgcucagcgucgac


ggaggcucuguggcucucuacguagacugugaagaauuccagagggugccauuugcucgggccucgcagggacuggagcu


agagcguggcgcuggccucuuugugggucaggcuggaacagcagacccugacaaguuccaggggaugaucucagagcuga


agguacgcaaaaccccccgggugagcccugugcacugucuggaugaagaagaugaugaugaagaccgggcaucuggagauu


uuggaaguggcuuugaagaaagcagcaagucacacaaggaggauacaucucuacuaccugggcucccucagccaccuccug


ucacuuccccaccccuggcuggaggcagcaccacagaagauccuagaacagaagaaacggaggaagacgccgcgguagauuc


uauaggagcugagacccuuccuggcacagguucaagcggugcaugggaugaggcuauccagaaccccggaaggggcuugau


aaagggagguaugaaaggacaaaagggagaaccaggugcccagggcccaccuggcccagcuggcccccaggguccugccgg


uccagugguccagagccccaacucacaaccugucccuggagcacaaggacccccgggaccucaggggccaccagggaaggau


ggcacuccaggaagggauggugaaccgggugacccuggugaagaugggagaccgggugacacuggaccucaaggcuuucca


gggaccccaggagaugugggcccuaagggcgagaagggagauccugguauugggccccgaggaccuccagggccuccaggg


ccaccaggacccuccuucagacaagacaagcugaccuucauugacauggagggauccgguuucagcggagacauagagagcc


uuagaggcccacgaggcuucccuggccccccggggcccccuggugucccaggacuuccuggugagccaggacgcuuuggga


ucaaugguuccuaugcaccaggaccugcaggccuuccugguguaccugggaaggaaggaccccccgguuuuccaggucccc


cgggaccuccagguccuccaggcaaagagggcccaccaggaguggccggccagaaaggcaguguuggugaugugggcaucc


caggacccaaggggagcaaaggagaccuugggcccaucgguaugccuggcaagucuggcuuggcuggauccccugggccag


uuggacccccaggaccuccagggccuccagggccaccaggaccaggauuugcugcuggauucgaugauauggaaggcucug


gaauaccccucuggacaacagcccgaagcucugaugggcugcagggaccucccgggucgccgggacucaagggggauccug


gaguggcaggccuaccuggagccaagggagaaguuggagcagauggagcccagggcaucccuggucccccaggaagagaag


gugcagcuggaucuccggggccaaaaggagagaaggggaugccgggagaaaagggaaacccaggaaaagauggagugggcc


ggccgggccucccugggccuccaggaccuccagggcuggugaucuaugugucaagugaggauaaagcaauagugagcacgc


caggaccugagggcaagccaggguacgcaggcuuuccuggaccugcuggaccgaagggugaccuggguuccaaaggcgagc


agggucuuccgggguuuaagggugagaagggagagccaggcacuaucuuuaguccugauggcagacgucugggccauccc


cagaagggagccaagggagagccaggcuuucgaggacccccggguccuuauggacgaccugggcacaagggugaaauuggc


uucccuggacggccgggucgaccuggaacgaauggcuuaaagggagagaagggagagccuggagaugccagccuuggguu


cagcaugaggggauugccuggccccccugggccuccaggacccccagguccuccugggaugcccaucuaugacagcaaugc


auuuguggagucuggccgaccuggacuaccaggacagcagggugugcaggggccuucaggaccaaagggugacaaaggaga


gguggggccaccugggccaccagggcaauuccccauugaccucuuccaccuggaagcggaaaugaagggggacaagggaga


ccgaggggaugcuggacagaaaggagagaggggagaaccuggggcuccuggugguggauucuucagcucaaguguaccug


gcccacccggcccaccuggauacccuggaauuccggguccaaagggagagagcauccgggggccaccuggcccuccuggccc


gcagggaccuccuggcauuggcuaugagggucgccagggucccccaggaccuccaggaccuccaggaccucccuccuuccc


uggcccucacagacagacugucaguguuccugguccuccgggcccaccugguccuccaggucccccaggagccaugggugc


cucugcugggcaggugaggaucugggccacauaccagaccaugcuggacaagauccgggaggugccggagggcuggcuca


ucuuuguggccgagagggaagagcucuauguacgcguuagaaauggcuuccggaaggugcugcuggaggcccggacagcc


cuccugagaggcacgggcaaugagguggcugcuuuccagcccccauugguccagcuucaugagggcaguccauacacccgg


agggaguacuccuauuccacggcacgacccuggcgagcagaugacauccuggccaacccaccgcgccugccagaccgccagc


cuuacccuggaguuccacaucaccacaguuccuaugugcaccugccgccagcccgccccacccucucacuugcucauacuca


ucaggacuuucagccagugcuccaccugguggcacugaacaccccccugucuggaggcaugcgugguauccguggagcaga


uuuccagugcuuccagcaagcccgagccguggggcugucgggcaccuuccgggcuuuccuguccucuaggcugcaggauc


ucuauagcaucgugcgccgugcugaccgggggucugugcccaucgucaaccugaaggacgaggugcuaucucccagcugg


gacucccuguuuucuggcucccagggucaagugcaacccggggcccgcaucuuuucuuuugacggcagagauguccugag


acacccagccuggccgcagaagagcguauggcacggcucggaccccagugggcggaggcugauggagaguuacugugagac


auggcgaacugaaacuacuggggcuacaggucaggccuccucccugcugucaggcaggcuccuggaacagaaagcugcgag


cugccacaacagcuacaucguccugugcauugagaauagcuucaugaccucuuucuccaaauaggccucugccagcuaggg


uggcagacagaggccaugcagaacuuugacacagcgcagggagcauucagucagcacccagggcucuggcugggauacaac


uccuguauaguucccauuuuuauguaauccucaagaaauaaaaggaagccaaagaguaaaaaaaaa
















TABLE 5





Genes down-regulated in HF stem cells.


















Gene
Fold

SEQ


Name/protein
Decr
Sequence
ID No.










Growth Factors, Receptors and Downstream genes










GNA- 14
32
Sequence below.
258


Mouse G





protein alpha





subunit (GNA-





14)





M80631










aacugccuucgagaagcguuagccuagagauccgagccucuucuccauaccauaguugguucaggugguuuccucuucaaa


ccuugcgucugcggauaauccgcgcggccgggcguuaagcuccaggucccugucgcuccgucgagguggcaagccauggcc


ggcugcugcuguuugucugcggaggagaaagagucucagcgcaucagcgcggagaucgagcggcacguucgccgcgacaa


gaaggacgcgcgccgggagcucaagcugcuguugcugggaaccggugagagugggaaaagcaccuuuaucaagcagaugag


gauaauccaugggucuggcuacagugaugaagauagaaagggcuucacgaagcugguuuaccaaaacauauucacggccau


gcaagccaugaucagagcaauggauacccugaggauacaauacaugugugagcagaauaaggaaaaugcccagaucaucagg


gaaguggaaguagacaaggucacugcacucucuagagaccagguggcagccaucaagcagcuguggcuggaucccggaauc


caggaguguuacgacaggaggagggaguaccagcugucagacucugccaaauauuaccugacggacauugagcguaucgcc


augcccucuuucgugccaacacaacaggaugugcuucguguuagagugcccaccacuggcaucauagaauauccauucgac


cuggaaaacaucaucuuccgaaugguggauguugguggccagcgaucugaacgacggaaauggauucacugcuuugagag


ugucaccuccaucauuuucuugguugcucugagugaauaugaccagguucuggcugagugugacaaugagaaccgcaugg


aggagagcaaagcccuguuuagaaccaucaucaccuaccccugguuucugaacuccuccgugauucuguucuuaaacaaga


aggaucuucuagaggagaaaaucauguacucucaucuaauuagcuacuucccagaguacacaggaccaaagcaagaugucaa


agcggccagggacuuuauccugaagcuguaucaagaccagaauccugacaaagagaagguuaucuauucucacuucacuug


ugcuacagacaccgagaauauccgcuuuguguuugcugcugucaaagacacaauccuacagcuaaaccuacgggaguucaa


cuugguguaaauggagggccuacuccuccgagacagagggugaucugagcccuuccugccugaucuacaagugcuucugg


accaggaccuaaggacauuauguagcccacaggacagagauggguagugcaaugugaaaaauacuucaccaacccuuuuaag


ugucuuuaauucuucacugucuaacucuuuucucgccuuuugguugaacgauuagguaucauuuuugagugguucccccu


cuccuauuuuuuuaaacuaguguucaacaguuauuaaaaaaucaugc













Ly6/Lympho-
12
gaauucccugcaaccuugucugagaggaagcaaggacuggugugag
259


cyte antigen 6

gagggagcugugagguuuuaucugugcagcccuucucugaggaug



complex

gacacuucucacacuacaaaguccuguuugcugauucuucuugugg



X04653

cccuacugugugcagaaagagcucagggacuggaguguuaccagug





cuauggagucccauuugagacuucuugcccaucaauuaccugccccu





acccugauggagucuguguuacucaggaggcagcaguuauuguggg





uucucaaacaaggaaaguaaagaacaaucuuugcuuacccaucugcc





cuccuaauauugaaaguauggagauccuggguacuaaggucaaugu





gaagacuuccuguugccaggaagaccucugcaaugcagcaguuccca





auggaggcagcaccuggaccauggcaggggugcuucuguucagccu





gagcucaguccuccugcagaccuugcucugaugguccucccaaugac





cuccacccuuguccuuuuauccucaugugcaacaauucuuccugga





gcccucuagugaugaauuaugaguuauagaagcuccaaggugggag





uagugugugaaauaccauguuuugccuuuauagcccugcuggguag





guaggugcucuaauccucucuagggcuuucaagucuguacuuccua





gaaugucauuuuguuguggauugcugcucaugacccuggaggcaca





cagccagcacagugaagaggcagaauuccaagguauuaugcuaucac





cauccacacauaaguaucugggguccugcaauguucccacauguauc





cugaaugucccccuguugaguccaauaaacccuuuguucuccc





Bmp4/Bone
11
Sequence below.
260


morphogenetic





protein 4





L47480










ggaagaaagagagggagggaaaagagaaggaaggaguagaugugagaggguggugcugagggugggaaggcaagagcgcg


aggccuggcccggaagcuaggugaguucggcauccgagcugagagaccccagccuaagacgccugcgcugcaacccagccu


gaguaucuggucuccgucccugaugggauucucgucuaaaccgucuuggagccugcagcgauccagucucuggcccucgac


cagguucauugcagcuuucuagagguccccagaagcagcugcuggcgagcccgcuucugcaggaaccaauggugagcaggg


caaccuggagaggggcgcuauucugaggauucgaggugcacccguaguagaagcuggggauggggcucaggcuguaaccg


aggcaaaaguuggccuauuccuccuuccuucuccaacaguguuggaggugggaugauggaggcuaaaaggcaccuccauau


auguuacugcgucuaucaaccuacuuuagggaggugcgggccaggagaggcgggaaggagagaaggccuuggaagagagg


ucauugggaagaacugugggguuugguggguuugcuuccacuuagacuauaagagugggagaggagggagucaacucuaa


guuucaacaccagugggggacugaggacugcuucauuaggagagagaaccuagccagagcuagcuuugcaaaagaggcugu


aguccugcuuugcucuaaagcgcgacccgggauagagaggcuuccuugagcggggugucaccuaaucuuguccccaacgca


cccccucccagccccugagagcuagcgaacuguagguacacaacucgcucccaucuccaggagcuauuuucuuagacauggg


cacccaugauucugccuucugguacucuccccucccugggaaagggguguaagguuccgacggaaccguggccaggaugcc


gaaaggcuaccugugcgggucuucugccaugcugugucugugcggacaugccagcagggcuaaugaggagcuugcgauac


uccaaaggguucgggaauugcgggguccuuacacgcaguggaguugggccccuuuuacucagaagguuuccgccacggcu


uugguugauaguuuuuuuaguauccugguuuaugaacugaagguuuugugagauguugaaucacuagcagggucauauu


uggcaaaccgaggcuacuauuaaauuuugguuuuagaagaagauucuggggagaaagugaaggguaacugccuccaggag


cuguaucaaccccauuaagaaaaaaaaaaauaccaggagaugaaaauuuacuuugaucuguauuuuuuaauuaaaaaaaauc


agggaagaaaggagugauuagaaagggauccugagcgucggcgguuccacggugcccucgcuccgcgugcgccagucgcua


gcauaucgccaucucuuucccccuuaaaagcaaauaaacaaaucaacaauaagcccuuugcccuuuccagcgcuuucccagu


uauucccagcggcgacgcgugucggggaauagagaaaucgucucagaaagcugcgcugaugguggugagagcggacuguc


gcucaggggcgcccgcggucucugcacccagggcagcagugugggauggcgcugggcagccaccgccgccaggaaggacgu


gacucuccauccuuuacacuucuuucucaaagguuucccgaaagugccccccgccucgaaaacuggggccggugcgggggg


ggggagagguuagguugaaaaccagcuggacacgucgaguuccuaagugaggcaaagaggcgggguggagcgggcucugg


agcgggggaguccugggacucgguccucggauggaccccgugcaaagaccuguuggaacaagaguugcgcuuccgagguu


agaacaggccaggcaucuuaggauagucaggucacccccccccccaaccccacccgaguuguguuggugaauuucuuggag


gaaucuuagccgcgauucuguagcuggugcaaaaggaggaaaggggugggggaaggaaguggcngngcggggguggcgg


uggggguggaggugguuuaaaaaguaagccaagccagagggagaggucgagugcaggccgaaagcuguucucggguuugu


agacgcuugggaucgcgcuuggggucuccuuucgugccggguaggaguuguaaagccuuugcaacucugagaucguaaaa


aaaaugugaugcgcucuuucuuuggcgacgccuguuuuggaaucuguccggaguuagaagcucagacguccaccccccacc


ccccgcccacccccucugccuugaauggcaccgccgaccgguuucugaaggaucugcuuggcuggagcggacgcugagguu


ggcagacacgguguggggacucuggcggggcuacuagacaguacuucagaagccgcuccuucuaacuuucccacaccgcuc


aaaccccgacacccccgcggcggacugaguuggcgacggggucagagucuucuggcugaaaguuagauccgcuaggggucg


gcugccugucgcuagaagcauuauuuggccucucggagacccguguggaggaagugcuggagugugcgaguguguuugc


gugugugugugugugugugugugugugugugugugugugugugugcgcgcgcccuuggagggucccuaugcgcuuucc


uuuucauggaacgcugucgugaggcuuugguaaacugucuuuucgguuccucucucggcugcacuuaagcuuugucggcg


cuguaaagagacgcgucuucaagugcacccugauccucaggcuucagauaacccguccccgaaccuggccagaugcauugca


cugcgcgccgcagguagagacgugccccacguccccugcgugcagcgacuacgaccgagagccgcgccagugugguguccc


gccgagaguuccucagagcaggcggggacaacucccagacggcuggggcuccagcugcgggcgcggagguuggccucgcuc


gcaggggcuggacccagccggggugggaggauggaggaggggcgggcgggcucuucggugaguggggcggggccucugg


guccacgugacuccuaggggcuggaagaaaaacagagccugucugcuccagagucucauuauaucaaauaucauuuuagga


gccauuccguagugccauucggagcgacgcacugccgcagcuucucugagccuuuccagcaaguuuguucaagauuggcuc


ccaagaaucauggacuguuauuaugccuuguuuucugucagugaguagacaccucuucuuucccuucuugggauuucacu


cuguccucccaucccugaccacugucugucccucccgucggacuuccauuucagugccccgcgcccuacucucaggcagcgc


uaugguucucuuucuggucccugcaaggccagacacucgaaauguacgggcuccuuuuaaagcgcucccacuguuuucucu


gauccgcugcguugcaagaaagagggagcgcgagggaccaaauagaugaaagguccucagguuggggcugucccuugaag


ggcuaaccacucccuuaccagucccgauauauccacuagccugggaaggccaguuccuugccucauaaaaaaaaaaaaaaaa


acaaaaaacaaacagucguuugggaacaagacucuuuagugagcauuuucaacgcagcgaccacaaugaaauaaaucacaaa


gucacuggggcagccccuugacuccuuuucccagucacuggaccuugcugcccgguccaagcccugccggcacagcucugu


ucuccccuccuccuguucuuaaccagcuggaaguuguggaaauugggcuggagggcggaggaagggcgggggugggggg


guggagaaggugggggggggggaggcugaagguccgaagugaagagcgauggcauuuuaauucucccuccnccucccccc


uuuaccuccucaauguuaacuguuuauccuugaagaagccacgcugagaucauggcucagauagccguugggacaggaugg


aggcuaucunauuugggguuauuugaguguaaacaaguuagaccaaguaauuacagggcgauucuuacuuucgggccgug


cauggcugcagcugguguguguguguguagggugugagggagaaaacacaaacuugaucuuucggaccuguuuuacaucu


ugaccgucgguugcuaccccuauaugcauaugcagagacaucucuauuucucgcuauugaucgguguuuauuuauucuuu


aaccuuccaccccaacccccuccccagagacaccaugauuccugguaaccgaaugcugauggucguuuuauuaugccaaguc


cugcuaggaggcgcgagccaugcuaguuugauaccugagaccgggaagaaaaaagucgccgagauucagggccacgcggga


ggacgccgcucagggcagagccaugagcuccugcgggacuucgaggcgacacuucuacagauguuugggcugcgccgccgu


ccgcagccuagcaagagcgccgucauuccggauuacaugagggaucuuuaccggcuccagucuggggaggaggaggaggaa


gagcagagccagggaaccgggcuugaguacccggagcgucccgccagccgagccaacacugugaggaguuuccaucacgaa


ggucaguuucugcucuuaguccuggcgguguagggugggguagagcrccggggcagaggguggggggugggcagcuggc


agggcaagcugaagggguuguggaagcccccggggaagaagaguucauguuacaucaaagcuccgaguccuggagacugu


ggaacagggccucuuaccuucaacuuuccagagcugccucugaggguacuuucuggagaccaaguagugguggugauggg


ggaggggguuacuuugggagaagcggacugacaccacucagacuncugcuaccncccagnggguguucuuuagcuauacc


aaagncagggauucugcccguuuuguuccaaagcaccuacugaauuuaauauuacancuguguguuugucagguuuauca


auaggggccuuguaauacgaucugaauguuuccuagcggauguuucuuuuccaaaguaaaucugaguuauuaauccucca


gcaucauuacuguguuggaauuuauuuucccuucuguaacaugaucaacaaggcgugcucuguguuucuaggaucgcugg


ggaaauguuugguaacauacucaaaaguggagagggagagaggguggccccucuuuuucuuuacaaccacuuguaaagaaa


acuguacacaaagccaagagggggcuuuaaaaggggaguccaagggugguggaguaaaagaguugacacauggaaauuauu


aggcauauaaaggagguugggagauacuuucugucuuugguguuugacaaaugugagcuaaguuuugcugguuugcuag


cugcuccacaacucugcuccuucaaauuaaaaggcacaguaauuuccuccccuuagguuucuacuauauaagcagaauucaa


ccaauucugcuauuuuuuguuuuuguuucuuguuuuuguuuuguuugguuuuuuuuuuuuuuuuuuuuuuuuugucu


cagaaaagcucaugggccuuuucuuuuccccuuucaacugugccuagaacaucuggagaacaucccagggaccagugagag


cucugcuuuucguuuccucuucaaccucagcagcaucccagaaaaugaggugaucuccucggcagagcuccggcucuuucg


ggagcagguggaccagggcccugacugggaacagggcuuccaccguauaaacauuuaugagguuaugaagcccccagcaga


aaugguuccuggacaccucaucacacgacuacuggacaccagacuaguccaucacaaugugacacggugggaaacuuucgau


gugagcccugcaguccuucgcuggacccgggaaaagcaacccaauuaugggcuggccauugaggugacucaccuccaccag


acacggacccaccagggccagcaugucagaaucagccgaucguuaccucaagggaguggagauugggcccaacuccgccccc


uccuggucacuuuuggccaugauggccggggccauaccuugacccgcaggagggccaaacguagucccaagcaucacccac


agcgguccaggaagaagaauaagaacugccgucgccauucacuauacguggacuucagugacgugggcuggaaugauugga


uuguggccccacccggcuaccaggccuucuacugccauggggacugucccuuuccacuggcugaucaccucaacucaaccaa


ccaugccauugugcagacccuagucaacucuguuaauucuaguaucccuaaggccuguuguguccccacugaacugagugc


cauuuccauguuguaccuggaugaguaugacaaggugguguugaaaaauuaucaggagauggugguagaggggugugga


ugccgcugagaucagacaguccggagggcggacacacacacacacacacacacacacacacacacacacacacacacguuccc


auucaaccaccuacacauaccacacaaacugcuucccuauagcuggacuuuuaucuuaaaaaaaaaaaaaagaaagaaagaaa


gaaagaaagaaaaaaaaugaaagacagaaaagaaaaaaaaaacccuaaacaacucaccuugaccuuauuuaugacuuuacgug


caaauguuuugaccauauugaucauauuuugacaaauauauuuauaacuacauauuaaaagaaaauaaaaugag













IL1r2/Inter-
11
gaaucccacuuacaugcgagcaucucuauauacauccucaaucuauc
261


leukin 1

cccucgaauccacggacuuaucagucaaucaauacuacagucaaaga



receptor, type

auuuuuuucuacguuauccuggagcauugcgcuggcaccucuuuuu



II

cuaaucaucuugguuguggggccaauauggaugcgcagacggugua



AV223216

aacgcagggcuggaaagacauauggacugaccaagcuacggacugac



X59769

aaccaggacuucccuuccagcccaaacuaaauaaaggaaaugaa






Wnt3a/wing-
 4
Sequence below.
262


less-related





MMTV





integration site





3A





X56842










gaauucaugucuuacggucaaggcagagggcccagcgccacugcagccgcgccaccucccagggccgggccagcccaggcg


uccgcgcucucgggguggacuccccccgcugcgcgcucaagccggcgauggcuccucucggauaccucuuagugcucugca


gccugaagcaggcucugggcagcuacccgaucuggugguccuuggcugugggaccccaguacuccucucugagcacucagc


ccauucucugugccagcaucccaggccugguaccgaagcagcugcgcuucugcaggaacuacguggagaucaugcccagcg


uggcugagggugucaaagcgggcauccaggagugccagcaccaguuccgaggccggcguuggaacugcaccaccgucagca


acagccuggccaucuuuggcccuguucuggacaaagccacccgggagucagccuuuguccaugccaucgccuccgcuggag


uagcuuucgcagugacacgcuccugugcagagggaucagcugcuaucugugggugcagcagccgccuccagggcuccccag


gcgagggcuggaaguggggcggcuguagugaggacauugaauuuggaggaauggucucucgggaguuugccgaugccag


ggagaaccggccggaugcccgcucugccaugaaccgucacaacaaugaggcugggcgccaggccaucgccagucacaugcac


cucaagugcaaaugccacgggcuaucuggcagcugugaagugaagaccugcugguggucgcagccggacuuccgcaccauc


ggggauuuccucaaggacaaguaugacagugccucggagauggugguagagaaacaccgagagucucguggcugggugga


gacccugaggccacguuacacguacuucaaggugccgacagaacgcgaccuggucuacuacgaggccucacccaacuucugc


gaaccuaaccccgaaaccggcuccuucgggacgcgugaccgcaccugcaaugugagcucgcauggcauagaugggugcgac


cuguugugcugcgggcgcgggcauaacgcgcgcacugagcgacggagggagaaaugccacuguguuuuccauuggugcug


cuacgucagcugccaggagugcacacgugucuaugacgugcacaccugcaaguaggagagcuccuaacacgggagcagggu


ucauuccgaggggcaagguuccuaccugggggcgggguuccuacuuggaggggucucuuacuuggggacucgguucuuac


uugagggcggagauccuaccugugagggucucauaccuaaggacccgguuucugccuucagccugggcuccuauuuggga


ucuggguuccuuuuuaggggagaagcuccugucugggauacggguuucugcccgaggguggggcuccacuuggggaugg


aauuccaauuugggccggaaguccuaccucaauggcuuggacuccucucuugacccgacagggcucaaauggagacaggua


agcuacucccucaacuaggugggguucgugcggaugggugggaggggagagauuagggucccuccucccagaggcacugc


ucuaucuagauacaugagagggugcuucagggugggcccuauuugggcuugaggaucccgugggggcggggcuucacccc


gacuggguggaacuuuuggagacccccuuccacuggggcaaggcuucacugaagacucaugggauggagcuccacggaagg


aggaguuccugagcgagccugggcucugagcaggccauccagcucccaucuggccccuuuccaguccugguguaagguuca


accugcaagccucaucugcgcagagcaggaucuccuggcagaaugaggcauggagaagaacucaggggugauaccaagacc


uaacaaaccccgugccuggguaccucuuuuaaagcucugcaccccuucuucaagggcuuuccuagucuccuuggcagagcu


uuccugaggaagauuugcagucccccagaguucaagugaacacccauagaacagaacagacucuauccugaguagagaggg


uucucuaggaaucucuauggggacugcuaggaaggauccugggcaugacagccucguaugauagccugcauccgcucugac


acuuaauacucagaucucccgggaaacccagcucauccgguccgugauguccaugccccaaaugccucagagauguugccuc


acuuugaguuguaugaacuucggagacauggggacacagucaagccgcagagccaggguuguuucaggacccaucugauuc


cccagagccugcuguugaggcaauggucaccagauccguuggccaccacccugucccgagcuucucuagugucugucuggc


cuggaagugaggugcuacauacagcccaucugccacaagagcuuccugauugguaccacugugaaccgucccucccccucca


gacaggggaggggauguggccauacaggagugugcccggagagcgcggaaagaggaagagaggcugcacacgcgugguga


cugacugucuucugccuggaacuuugcguucgcgcuuguaacuuuauuuucaaugcugcuauauccacccaccacuggau


uuagacaaaagugauuuucuuuuuuuuuuuuucuuuucuuucuaugaaagaaauuauuuuaguuuauaguauguuuguu


ucaaauaauggggaaaguaaaaagagagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa













Il12rb2/
 3
Sequence below.
263


Interleukin 12





receptor, beta 2





U64199










cgcaccggagguccacacugccgcguggacuccagcgauggcgcugcgcuaggcuagcgggugccaggaucccucucugcg


uccugugcgcgggaagagcucuggagaaccagaguugcauucuggaguugaagacucauggcacagacuguuagagaaug


cucauuggcacuucuuuuuuuguucauguggcugcugauuaaagcaaauauagaugugugcaagcuuggcacugugaccg


uccagccugccccugugauuccucuugggucagcugccaauauuuccugcuccuugaaucccaagcaaggcuguucacauu


aucccaguucuaacgaauuaauccucuuaaaguuugucaaugauguccuuguugaaaaucuccauggcaagaaaguccaug


accacacuggucacuccuccacuuuucaagucaccaaccugucccuugguaugaccuuguuugucugcaagcuaaacugua


gcaacucucaaaagaagccaccagucccaguaugugggguggagaucucaguugguguugcuccagagccaccucaaaaca


uaucauguguccaggaaggagaaaauggaacuguggccuguuccuggaacucuggaaaaguuacuuaucugaaaaccaauu


acacuuuacaguuaaguggaccaaacaaucugaccugucagaaacaauguuuuucugacaaucgucagaauugcaaucgcc


uggaucuugggaucaaucuaagcccugauuuagcugaauccagguucauaguccguguuacugccaucaacgaucuuggaa


auucuucuucacuuccgcauacguucacguucuuggacauagugaucccucuuccuccgugggacaucagaaucaacuuuc


uaaaugcuucugggagcagagguacacugcagugggaagaugaggggcaagugguacucaaucaacucagauaucagccuc


uuaacagcacguccuggaacauggucaaugcuacaaaugccaaaggaaaauaugaccugcgagaucugagaccguuuacaga


auaugaauuucaaaucuccucuaagcuacaucucucuggaggaaguuggaguaauuggagugagucacugagaacacgaac


accagaggaagagccuguugggauauuagacaucugguacaugaaacaagacaucgacuaugacagacagcagaucucucu


uuucuggaagagucugaauccaucagaggcaagggggaagauccuccacuaucaggugacguuacaagaggugacaaagaa


aacaacacugcagaauacuacaagacacaccuccuggaccagggucaucccccgaacuggggcuuggacggcaucagugucu


gcagccaacucaaaaggcgcuucugcacccacucacauuaacauaguggaccuauguggcacuggguugcuggcuccucac


caggucucugcaaagucggagaacauggacaacauucuagugaccuggcagccuccuaagaaagcugauucugcuguucgg


gaguacauaguggaauggagagcucuccaaccagggagcaucacgaaguuucccccacacuggcugcggauccccccggaca


acaugucugcucugauuucagagaacauaaagcccuauaucuguuaugaaaucagggugcaugcacugucagagagccaag


gagggugcagcuccauccggggugacuccaagcacaaagcaccagugaguggcccucacauuacugccaucacagagaaaaa


ggaacgccuuuucauuuccuggacccacauuccauucccggagcaaaggggcugcauccuccauuacagaauauacuggaa


agaacgagacucgacagcacaaccugagcucugcgaaauucaguaccgacgcucucaaaacucacauccaauaagcagccuac


agcccagggugacauauguccuauggaugacagcugugacagcugcuggugaaaguccccaaggaaaugaaagggaauuuu


guccacagggcaaagccaacuggaaagcauucgugauaucaagcauuugcaucgcuaucaucacggugggcacguucucaa


uucguuacuuccggcaaaaggcauuuacucuccugucuacucucaaaccucaaugguauagcagaaccauuccagauccagc


aaacagcacuuggguaaagaaguaucccauucuggaggagaagauccagcuaccuacggauaaucuccugauggcauggcc


cacuccugaagagccugagccccugaucauccaugaaguccucuaccacaugaucccaguugucagacaaccauauuacuuc


aaaagaggccaaggauuccaaggcuacucuaccuccaagcaagaugcaauguauauugccaauccacaagcuacaggaacuc


ucacagcugagaccagacaacuagugaaccuauacaaggugcuagaaagcagagacccugacucaaaacuggccaaccugac


cagccccuugacagucaccccagugaacuaccuuccuagccaugaaggcuauuuacccuccaacauagaagaucugucacca


caugaggcugacccaacugauucuuuugaccuggagcaucaacauauuucucuuuccauuuuugcaucaaguucucuccgc


ccacucaucuucgguggugagcggcugacucuagaucgguuaaagaugggcuaugacucccucaugaguaaugaggcuug


auacuagaaagccaacguaccucauuuuaucugcccaguuccuacuccaaaggucugugacagugaagacaagccagcuguc


ucuggauaaaguuagcuucaccauagguacuuaagucuuauggauaagguggcaauacaccaacacugauaucauauagaa


aggaccccaagauagucaugcuc













Wnt10a/Wing-
 3
Sequence below.
264


less-related





MMTV





integration site





10a





U61969










ggcacgaguucacccucugcaugcguuccccuccccccucuccagcaaacacggcgcgccaguccaaagcggacucaguggc


cucggggacgggagcaugccaccuccuguggugacgucacuugggguagaacccuuagacacuacauggggggggggggu


acagaacucccgagccaggacagucacucacucuucaggcgguggggcugggccagacaguaccgcccccaccgcgcccgcc


ucgcacacccucggaagcgcaggcucgcagcgcggcgcuggggugggggguugcgccccagaacuucggccuccagucccc


agcccgcugcaccuccuuacccucuagaggcccccucccccuuacccucuagaggcaccaggaguugucgcaaggggcccuu


gggaaauucccuggaccccugugccaggaggugcccgguucgcccgcuccccauccacccccccgagggcggugcccgggg


gcgcugccccauggagcggggaggcgggcgccgucugcugcgggagcugugaccugaguaggagcugugugucgcagccg


ccccaccccugccgaucaugcgccggcgacccugguucgccagucccacugggcugugagccccccacuccuggccugucac


ggcccgcgcgccaugggcagcgcccacccucgccccuggcugcggcucccacaagggccccagccgcggccugaguucugg


gcgcuccuguucuuccuacugcugcuggcugccgcugugcccaggucagcacccaacgacauccugggccuccgccuaccc


ccagagcccgugcucaacgccaacacagugugccugacauugcccggccugagccggcggcagauggaggugugugugcgu


cacccugacguggccgccucugcuauccagggcauccagaucgccauccaugagugccagcaucaguuccgggaccagcgc


uggaacugcuccagccuggagacucggaacaaaguccccuacgagagccccaucuucagccgagguuuucgagagagugcu


uucgccuacgccauagcagcugccgggguggugcacgcaguguccaacgcgugcgcucuggguaaacugaaggcuugcgg


uugcgacgccuccagacguggggacgaagaagcuuuccgucggaagcugcaccgcuugcagcuggacgcgcugcagcgcgg


aaagggcuugagccacggggucccugaacacccggccauacuuccugccagcccaggucugcaggacuccugggagugggg


uggcugcaguccggaugugggcuucggagaacgcuucucuaaggacuuucuggacucccgagagccucacagagacaucca


ugcucgaaugagacuccacaacaaccgugugggccggcaggcggugauggagaacaugcggcguaagugcaaaugccacgg


caccucaggcagcugccagcucaagaccugcuggcaggugacgccugaguuccgcacaguaggggcgcugcugcgcaaccg


cuuccaccgcgccacgcucauccggccgcacaaccgcaacgguggccagcuggagcccggccccgcgggagcacccucgcca


gcaccgggcacuccagggcugcgccgcagggccagccacuccgaccuggucuacuuugagaaaucucccgacuucugugag


cgcgagccgcgccuggacucggcaggcacugugggccgccugugcaauaagagcagcacgggucccgauggcugcggcagc


augugcuguggccgcggccacaacauucugcgccagacgcgcagcgagcgcugccacugccgguuccacuggugcugcuuc


guggucugcgaagaaugccgcaucaccgagugggucagcgucugcaagugagcagacccaagcuccucugggucucaagaa


ugguuguccucuuggugccuggcuucugccgcuagcggaucugagccaggcagcaagcagcagccuuggcuccugagaga


ggugguuggcucuuacagccccgagggucuacaaucaccagacaguccagaucugauugacauuccuccgcucaccucugu


agguuccccucuuucuguuccuagcucagacagcugggggugauaguggagacuguuccacacccuaggacaggucaccaa


agcagcccagccuggcaugccuaccuccugucaucucuucuucccuuccccaggagugauaggcaaugcacugaagcugau


gggcaccggggaagaaaacuaaaaggcagaaauggccgucaucgggcugaagugacucuaagggcuccagaccucugcucc


ugucuuucacuuaacagauauuuauuuuugcgcucucuuugagacacucucuggggaaaaagaagcuccggagucuacag


gcugauuaagggacauggacaauaaaccaguaaacacacaaaaaaaaaaaaaaaaaa













Ifngr2/Inter-
 3
Sequence below.
265


feron-gamma





receptor





precursor





M28233










gaauuccgggccgcuugcacuuggcgacuagucugcggcggacgugacgccaaggccacgggcagcgcggguccccuguca


gaggugucccucgcgcaggaaugggcccgcaggcggcagcuggcaggaugauucugcuggugguccugaugcugucugcg


aaggucgggaguggagcuuugacgagcaccgaggauccugagccucccucggugccuguaccgacgaauguucuaauuaag


ucuuauaacuugaacccugucguaugcugggaauaccagaacaugucacagacuccuauuuuuacuguacagguaaaggug


uauucggguuccuggacugauuccugcaccaacauuucugaucauuguuguaauaucuaugaacaaauuauguauccuga


uguaucugccugggccagaguuaaagcuaagguuggacaaaaagaaucugacuaugcacggucaaaagaguuccuuaugug


ccuaaagggaaaggucgggcccccuggccuggagaucaggaggaagaaggaagaacagcucuccguccucguauuucaccc


ugaagucguugugaauggagagagccagggaaccauguuuggugacgggagcaccuguuacacauucgacuauacugugu


auguggagcauaaccggaguggggagauccuacauacgaaacauacggucgaaaaagaagaguguaaugagacucugugug


aguuaaacaucucaguauccacacuggauuccagauauuguauuucaguagacggaaucucaucuuucuggcaaguuagaa


cagaaaaaucgaaagacgucuguaucccuccuuuccaugaugacagaaaggauucaauuuggauucuggugguugcuccuc


uuaccgucuuuacaguaguuauccugguauuugcguauugguauacuaagaagaauucauucaagagaaaaagcauaaugu


uaccuaaguccuugcucucugugguaaaaagugccacguuagagacaaaaccugaaucgaaguauucacuugucacaccgc


accagccagcuguccuagagagugagacggugaucugugaagagccccuguccacagugacagcuccagacagccccgaagc


agcagaacaggaagaacuuucaaaagaaacaaaggcucuggaggcuggaggaagcacgucugccaugaccccagacagcccu


ccaacuccgacacaaagacgcagcuuuucccuguuaaguaguaaccagucaggcccuuguagccucaccgccuaucacuccc


gaaacggcucugacaguggccucgugggaucgggcagcuccauaucggacuuggaaucucucccaaacaacaacucagaaac


aaagauggcagagcacgacccuccacccgugagaaaggcccccauggccuccgguuaugacaaaccgcacauguugguggac


gugcuuguggauguuggggggaaggagucucucaugggguauagacucacaggagaggcccaggagcuguccuaaggucu


cccgaggccugcuggugguaaagaaacugaccuuuuaggcaguuuuucugcauugauuucaugaaagaagcuauacauua


gcuaauacuaaccacauagaauaucagacuuagauacgugaauaaggauccugugggcacugcuggguccacucugcaaau


gccaagacuaucaaaggaacguauugucgcuucuggcuccuucccaggugggcuagcaucugugaguuugccucggcuag


ccuugcuuccuacagccgccacugcuccuccacccugaucaucucacaggacaggguggaccggguuuuuuuuuuuuuuuc


acacaccuuuguauauguaaguucauguauauaauauguuuacauguuucacuuugaacugaaagcuacucaaagccagcc


guaagucuaugguagaaugugauggaacauguugguggaagcuuguacaauagaacacauuggugggagcuuguacauac


uuuuuuauggagcauuacuuacgauuuuuuaaguaaaauguuuugaaaccaaaaaaaaaaaaaggaauuc













Fgfbp1/
 3
augagacuccacagccucauccugcucuccuuccuucuccuggcuac
266


Fibroblast

ucaggcguucucagaaaaggucagaaagagagccaagaacgcaccac



growth factor

acagcacagcggaggaggggguagaggguucagcucccucguuagg



binding protein

gaaggcccagaauaagcagagaagcaggacaucuaaaucucugacgc



1

auggcaaguuugucaccaaagaccaagccacaugcagaugggcugug



AF065441

acugaggaggagcagggcaucagccugaagguccagugcacacaagc





cgaucaggaguuuucuuguguuuuugcuggugacccaacugacugc





cuuaaacacgacaaagaccagaucuacuggaaacagguugcccgcac





gcugcgcaaacagaaaaauaucugcaggaacgccaagagugucuuga





agaccagagugugcagaaagagauuuccagagucuaaccucaagcug





gugaaccccaacgcacguggaaacacgaagcccaggaaggagaaagc





agaggucuccgcaagggagcacaacaagguccaagaagcugucucca





cggagccaaacagggucaaagaagacaucacacucaauccagcugcg





acccagaccauggccauuagagauccagagugucuagaggauccaga





ugugcucaaccagaggaagaccgcccuggaguucuguggggaaucu





uggagcuccauuugcacauucuuccucaacauguuacaggcgacauc





augcuaa










Transcription Factors and Related Genes










Klf5/Kruppel-
 5
aauucgucgacaugcgccguuccagugcauggugugccaacgcagc
267


like factor 5

uucucccgcuccgaccaccucgcgcugcacaugaagcgccaccagaa



AA611766

cugagcgagcgagcgcugccccacccgccugacgccuugcaguccgc





ucugccauccuuuaaaccgcagaccuaacuucauaaaaaga






Gata3/GATA
 4
Sequence below.
268


binding protein





3





X55123










gcuaaacuaucccgcaaagauuuuucuuuccucccuaaacccuccuuuuugcucuccuuuucuauacccuuaacugcaaaca


aaccauuaaacgaccccucuccugggccuccgacggcaggaguccgcggaccucccaggccgacagcccucccucuacccgc


gagguuccgggccgggcgagagggcgcgagcacagccgaggacauggaggugacugcggaccagccgcgcugggugagcc


accaucaccccgcgguccucaacggucagcacccagacacgcaccacccgggccucggccauucguacauggaagcucagua


uccgcugacggaagagguggacguacuuuuuaacaucgauggucaaggcaaccacgucccguccuacuacggaaacuccgu


cagggcuacggugcagagguauccuccgacccaccacgggagccagguaugccgcccgccucugcugcacggaucucugcc


cuggcuggauggcggcaaagcccugagcagccaccacaccgccucgcccuggaaccucagccccuucuccaagacguccauc


caccacggcucuccggggccucuguccguuuacccuccggcuucauccucuucucuggcggccggccacuccaguccucau


cucuucaccuucccgcccaccccgccgaaagacgucuccccagacccgucgcuguccaccccgggauccgccgggucggcca


ggcaagaugagaaagagugccucaaguaucaggugcagcugccagauagcaugaagcuggagacgucucacucucgaggca


gcaugaccacccuggguggggccucauccucagcccaccaccccauuaccaccuauccgcccuaugugcccgaguacagcuc


uggacucuucccacccagcagccugcugggaggauccccuaccggguucggauguaagucgaggcccaaggcacgauccag


cacagaaggcagggagugugugaacugcggggcaaccucuaccccacuguggcggcgagaugguaccgggcacuaccuuug


caaugccugcggacucuaccauaaaaugaaugggcagaaccggccccuuaucaagcccaagcgaaggcugucggcagcaagg


agagcagggacauccugcgcgaacugucagaccaccaccaccacccucuggaggaggaacgcuaauggggacccggucugca


augccugugggcuguacuacaagcuucauaauauuaacagaccccugacuaugaagaaagaaggcauccagacccgaaaccg


gaagaugucuagcaaaucgaaaaagugcaaaaaggugcaugacgcgcuggaggacuuccccaagagcagcuccuucaacccg


gccgcucucuccagacacaugucaucccugagccacaucucucccuucagccacuccagccacaugcugaccacaccgacgcc


caugcauccgcccuccggccucuccuucggaccucaccacccuuccagcauggucaccgccauggguuagagaggcagagcc


cugcuccacaugcgugaggagucuccaagugugcgaagaguuccuccgaccccuucuacuugcguuuuucgcaggagcagu


aucaugaagcccgaaagcgacagaucuguguuuuugaaggcagaaagcaaaauguuugcuucuuuuuucaaaggagcucga


gguggugucugcauuccaaccacugaauccggaucccauuugugaauaagccauucagacucauauucccuauuuaacagg


gucucuagugcugugaaaaaaauauugcugaacauugcauauaacuuauauuguaagaaauacuguacauuugaggaagac


uuuauuguaccuggauagcuguaagaaaggcaugaaggacgccaagaguuuuaaggaauauaggggnnuuaaaguaugga


gauacagaagaaaccacuaagucugauguccaaaugggcacacugucaguuuuguuucccuucaguuguuugaugcauuua


aaaaaaaaaaaaagaaagaa













Stimulated by
 3
Sequence below.
269


retinoic acid





14, basic-helix-





loop-helix





protein





Y07836










caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucagggauggauuuugcccacauguacc


aaguguacaaguccaggcggggaauaaaacggagcgaagacagcaaggaaacuuacaaacugccgcaccggcugauugagaa


aaagagacgugaccggauuaacgagugcauugcccagcugaaggaucuccuacccgaacaucucaaacuuacuacuuuggg


ucacuuggaaaaagcagugguucuggagcuuacguugaagcacgugaaagcauugacaaaucuaauugaucagcagcagca


gaaaaucauugcccugcagagcgguuuacaagcuggugauuugucgggaagaaaucucgaggcagggcaagaaauguucu


gcucagguuuccagacuugugcccgugagguacuucaguaccuggcgaagcaugagaacacucgggaccugaaaucuuccc


agcucgucacucaucuccaucguguggucucggagcugcugcaggguggugcuuccaggaaaccauuggacucggcuccca


aagccgucgacuugaaagagaagcccagcuuccuagccaagggaucagaaggcccagggaaaaacugugugccagucaucca


gcggacuuuugcucccucggguggggagcagagcggcagugacacggacacagacaguggcuauggaggugaauuggaga


aaggggacuugcgcagugaacagccguacuucaaaagcgaccauggacgcagguucgccgugggagaacgugucagcacaa


uuaagcaagaauccgaagagccccccaccacaaagagccgaaugcagcucucagaagaggaaggccacuucgcgggcaguga


ucugauggguuccccauuucuugggccacacccacaucagccuccuuuuugccuucccuucuaucucaucccaccaucggc


cacugccuaccugccuaugcuggagaaaugcugguaccccaccucugugccaguguuauacccaggccucaacaccucagcu


gcagcccucuccagcuucaugaacccagacaagauaccgacucccuugcuucugccccagagacucccuucuccuuuggcac


auucgucccuugacucuucggccuugcuccaggcuuugaagcagaucccuccuuuaaacuuagaaaccaaagacuaaacuc


uggagggaucuccugcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccugagugcagagagauca


gcccacccugcagacccacagagaagauucagagugugugugagagugagugagugugcgugcgugcgugcuuguaugua


uguuuguauauguaggacaauaaguuccuucugacacaagggagacacgagaaggauagccugacaucagaugacagacug


gaggacuguagcacaucucugggcguuucccuacccagagaagagcc





Cell Cycle Related










Mki67/antigen
 4
Sequence below.
270


identified by





monoclonal





antibody Ki67





X82786










agucaccgacguuguauaacgacggccagugaauuguaauacgacucacuauagggcgaauuggguaccggccccccccuc


gaggucgacgguaucgauaagcuugauaucgaauucucgnccgcgugcgggucuggucggggcggagcgaaggccgcggg


uggccguggucgguccuccgcggcuaaggagccgagggcuccgacgcgggcugcgcccggugagcggcggccagagcuaa


cuugcgcugacuggaccagcugaggagcggcccggcggggcgacugcgagcuucaccgagaggcuucuccgcccugguccg


cagucccgacggccgggcggaccauggcguccucggcucaccuggucaccaucaagcggagcggcgaugacggcgcacacu


ucccgcugagccucagcuccugccuguuuggaaggaguauugaaugugacauucguauccagcugccuguagugucucaa


agacauugcccaauuguaguccaagagcaagaggcgauauuauauaauuucaguucuaccaauccaacucaaguaaacggg


guuacuauagaugagccugugaggcugagacauggagacauaauaaccaucauugaccgcuccuuuagguaugaagaugga


aaucaugaggauggaagcaaaccaacagaauuuccaggaaagucccuuggaaaggaaccaucaaggcgagccucaagagaua


gcuucugugcugacccugauggggaaggucaagauaccaaagcuucaaaaaugacugcuucaagaagaucuuuuguguaug


ccaagggccuuucugcagauagcccugccucagauggcucaaagaacaguguuagccaagacucaucagggcauguagaac


agcacacuggcagaaacauaguagagcccacuucugggggaucucuuuuaagaaguccaggucuacagggagcaguuacag


ggaaccgaagucuucuuccuacacagagccuuagcaauagcaacgaaaaggaaucucccuuugagaaacuuuaucaaucaau


gaaggaagaguuggauguaaaaucccagaaaucuuguaggaaaucagaaccccaaccugaccgugcagcagaggaaucgcg


ggagacacagcuauuggugucaggcagggcaagagcaaagucuaguggaagcaccccuguuacugcagccucuucacccaa


aguaggaaagaucuggacugagagauggcgcgguggaauggugccuguccagacuuccacagagacagcuaaaaugaagac


cccugugcggcauucacagcaacuuaaggaugaagacucucguguuacuggcagacgacauucugugaaucuggaugaagg


uggaagugcccaggcaguccauaaaacagucacuccugggaaacuggcgacuagaaaccaaacuccgguggaggcugggga


uguuggcagccccgcugauacaccagaacauuccucuuccccccagagaaguauuccugcaaagguagaggcuccaucugca


gagacacaaaaucggcucucuuuaacucagcgccuuguuccaggugaaaagaaaacucccaaggguuccuucagcaagccug


agaaacuggccacagccgccgaacagacuugcucuggccuaccuggucuuaguuccguugauaucagcaacuuuggugauu


ccauuaacaagagugagggaaugccuaugaagagaagacguguauccuuugguggacaucuaagaccugaauuauuugaug


aaaacuugccuccuaauacaccacugaaaagaggagaaacgccaaccaagaggaagucucuuggcacucacagcccagcugu


ccucaagacaaucaucaaggaacggccccagucuccagggaaacaagagucuccugggauaacgccaccgaggacaaaugau


caaagacgcagaucaggcaggacuuccaguggaagcaauuucuuaugugagacagacauucccaagaaagcaggcaggaaga


gcgguaaccugccugcgaagagagcauccaucagccggagucagcauggcauucuacagaugauuugcuccaaaaggcgaa


guggagcuucugaagccaacuugauuguugcaaaaucaugggcugauguuguaaaacuuggcgugaaacaaacacaaacga


aaguugcgaaacaugucccuccaaagcagacgagcaagagacaaagaagacccagcacuccaaagaaacccacaagcaaucuu


cacaaucaauuuacuacaggccaugcaaacucucccuguaccauuguaguagguagagcgcagauugaaaaaguaagugug


ccugcccgacccuacaaaaugcugaauaacuugaugcuaaaccgaaaaguggacuucagugaagaucugucaggacuaacug


aaauguucaagacuccagugaaggagaagcagcagcagaugagugauacaggcuccguacuuuccaauucagcgaauuugu


cugaaagacaauugcaaguaacuaauucaggagacauaccugagcccaucaccacagagauuuugggagaaaaagugcuauc


caguacucggaaugcagcaaagcagcagucugauagauauucugcaaguccuaccuuaagacggcggagcaucaaacaugaa


aacacagugcaaacuccuaagaauguccauaacauuacugaccuugagaagaagacuccggucucugagacagagccccuga


agacugcaucgagugugagcaaguuaagaagaucuagagagcucagacauacccuuguggaaacuaugaaugaaaaaacag


aagcaguccuugcugagaacaccacagcaagacauuuaagggggacauuucgagaacaaaaaguagaucaacaggugcagga


caaugaaaacgcuccucaaagaugcaaggaaaguggugaauuaagugaagguucagaaaagacaucagcuaggagaucaag


ugccaggaagcagaagccgacaaaagacuuacuaggaagucagauggucacccaaacagcagacuaugcugaggaacuacuu


agucaaggacaaggaaccauacaaaaccuagaggaauccaugcacaugcaaaacacaucaauaagugaggaucaaggaauua


cagaaaagaaagugaacauaauaguauaugcaaccaaagagaagcacucgccaaagaccccuggcaaaaaggcacaaccucua


gaagggccagcuggucucaaggaacacuuugaaacaccaaaccccaaagauaaaccuauaacggaagacagaacuagagucc


uuugcaaaucaccacaagucacaacagagaauaucacaacaaacacaaagccacagacuagcacaucugggaagaaaguagac


augaaggaagaaagcucugccuugacaaaacguauacauaugccaggggaauccaggcauaaucccaaaauuuuaaaacuug


agugugaggauaucaaagcuuugaagcaaucugaaaaugaaaugcugaccucaacaguaaauggaagcaagaggacuuuag


gaaaaucuaaaaaaaaggcucagccccuggaagaccugacuuguuuccaggaacucuuuauaucaccaguuccuacuaacau


aaucaaaaaaauucccagcaaaucuccacacacacaaccagucagaaccccagcgagcacaaagagacucuccaagacagguc


ucaguaaaguggaugugagacaagaaccuucaacacuugggaaaagaacgaagucaccaggcagagccccaggcacaccagc


accagugcaggaagaaaaugacugcacagccuacauggaaacuccaaagcagaaacuggagucuauagaaaauuuaacaggg


cuuaggaaacaguccagaacaccuaaagacaucacugguuuccaggauaguuuccaaauaccagaucaugcuaauggcccau


uagugguugucaaaaccaaaaaaauguucuuuaauucuccacaaccagaaagugccauaacccgaaagagcagagagagaca


gucuagggcaaguauaaguaaaauagauguuaaagaagaacuuuuagaaucagaggaacaccuacaauuaggagaaggugu


agacacauuucagguauccaccaacaaagucauuagaucaucuaggaaaccugcaaagcguaaacuggauucaacagcuggu


augccuaacagcaagaggaugcgcuguucuucaaaggauaacacaccaugccuagaagaccugaauggcuuccaagagcucu


uccaaaugccaggcuaugcuaaugacucuuugaccacuggaaucucaacaaugcuugcuagaucaccacaauuaggaccagu


uagaacccaaaucaacaaaaagagucugcccaagaucaucuugagaaaaauggaugugacagaagaaauuucaggucucugg


aagcagucacugggcagaguccacaccacacaagagcaggaggauaaugcaaucaaagcaauuauggagauuccaaaggaaa


cacugcagacugcagcagauggaacuaggcuuaccagacagccacaaacaccuaaggaaaaaguucaaccgcuggaagauca


cagugucuuccaagaacucuuccaaacaucacgcuacuguucugauccauuaauugguaacaaacaaacaagaauguccuug


agaucuccacaaccaggauuuguuagaacuccacgaaccucaaagagacuggcuaagacaaguguugggaauauugcugug


agagaaaagaucucuccagugagucugccacagugugcuacaggggagguuguacacauacccauagggccagaagaugac


acagagaacaaaggugugaaggaauccacaccucagacacuggacucaucagcaagucgaacugucagcaagaggcagcaag


gggcacaugaggaaaggccucaguucucaggagacuuauuucauccccaagagcucuuucaaacaccagccaguggcaaaga


cccaguaacuguugaugaaacuacaaaaauagcucugcagucuccacaaccaggacauaucauaaacccagcaagcaugaag


agacaguccaacaugagucucaggaaagacaugagagaauuuuccauacuugaaaaacaaacacagucacgaggcagagacg


caggcacaccagcaccaaugcaggaagaaaauggcaccacagccauuauggaaacaccaaagcagaaacuggauuucauagg


aaauucaacaggacauaagaggaggccucggacacccaaaaacagggcucagccccuagaagaccuggauggcuuccaagaa


cucuuucaaacaccagcuggugccagugacccugugaguguugaagaaagugcaaagauaucuuuggcaucuucacaagca


gaaccagucagaaccccagcaaguacaaagagacgcuccaagacaggucucaguaaaguggaugugagacaagaaccuucaa


cacuugggaaaagaaugaagucacuaggcagagccccaggcacaccagcaccagugcaggaagaaaaugacagcacagccuu


cauggaaacuccaaagcagaaacuggauuucacaggaaauucaucaggacauaagaggaggccacagacaccuaagaucagg


gcucagccccuagaagaccuggauggcuuccaagaacucuuccaaacaccagcuggugccaaugacucagugacuguugag


gaaaguguaaagaugucuuuggaaucuucacaagcagaaccagucaaaaccccggcaagcacaaagagacucuccaagacag


gucucaguaagguggaugugagagaagacccuucaauacuugagaaaaaaacaaagucaccaggcacaccagcaccagugca


ggaagaaaaugacugcacagccuucauggaaacuccaaagcagaaacuggauuucacaggaaauucaucaggacauaagagg


aggccacggacaccuaagaucagagcucagccccuagaagaccuggauggcuuccaagaacucuuccaaacaccagcuggug


cuagugacucagugacuguugaggaaagugcaaagaugucuuuggaaucuucacaagcaaaaccagucaaaaccccggcaa


gcacaaagagacucuccaagacaggucucaguaagguggaugugagagaagacccuucaacacuugggaaaaaaacaaaguc


accaggcagagccccaggcacaccagcaccagugcaggaagaaaaugacagcacagccuucauggaaacuccaaagcagaaac


uggauuuugcagagaauucaucagggaguaagagaaggucacgaacaucuaagaacaggucucagccccuagaagaccugg


auggcuuccaagaacucuuccaaacaccagcuggugccaguaacccugugaguguugaagaaagugcaaagauaucuuugg


aaucuucacaagcagaaccagucagaacccgggcaagcacaaagagacuuuccaagacaggucucaauaagauggaugugag


agaagggcacucuccgcucaguaagucaagcugugcaucacagaaagucaugcaaacccucacacuuggagaagaucauggc


agagagaccaaagaugggaagguauuguuagcucagaaauuggaaccagcaauauauguuacucguggcaagaggcagcaa


aggucauguaagaaaaggucccaguccccagaagaccucucugguguucaggaggucuuccaaacaucaggccauaacaag


gauucagugacaguggacaaucuugcaaaacugcccagcucgucuccaccacuagagccaacagacacuucaguaaccucac


ggagacaggccagaacuggucugaggaaaguucacgugaaaaaugaacuuucaggaggcauaaugcauccacaaauaucag


gggaaauuguggacuuaccuagagaaccagaaggugaaggcaaagucauuaaaacaaggaagcaaucuguaaaacggaaau


uggacacagaagucaaugugccucgcaguaagaggcaaagaauuacaagagcagaaaagacccuagaggaucugccuggcu


uccaagagcucugccaagcuccaagcuugguaauggacucaguuauuguugagaaaaccccaaagaugcccgacaaaucucc


agaaccuguggauacaacuucagagacacaggcaagaagaagacucaggagacugguuguuacugaagagcccauaccacaa


agaaagacuacaagaguuguaaggcaaaccagaaacacacagaaagagcccauaagugacaaucaagguauggaagaguuua


aggaaucuucaguacagaaacaagacccaaguguaaguuuaacuggcaggaggaaccaaccaaggacaguuaaggagaaaac


ccaacccuuagaagaacucaccaguuuccaagaggaaacugccaaaagaauaucuuccaaaucuccacaaccggaagagaagg


aaaccuuagcagguuuaaagaggcagcucagaauacaacuaaucaacgaugguguaaaagaagagcccacagcacagagaaa


gcaaccauccagggaaaccaggaacacacucaaagagccuguaggugacaguauaaauguugaagagguuaagaagucuaca


aagcagaaaauugauccaguagcaagugugccugucagcaagaggccacggaggguacccaaggaaaaggcacaggcccuag


aauuggcuggucucaaaggaccaauccaaacccuaggccacacugaugaaucagcaagugauaaaggacccacacagaugcc


cuguaauucucuacaaccagagcaaguugacagcuuccaaagcucaccaaggcgacccaggacaagacgugggaaaguagag


gcagaugaagagccuucagcaguaagaaagacaguaucaacaucaaggcaaacuaugcgaucccgcaaggucccugaaauug


guaacaaugguacccaaguuucaaaggccuccauaaagcagacauuagauacaguagccaaaguaacuggcagcaggaggca


gcuaaggacacauaaaggaugggguucaacccucuugaaguuguuaggugacuccaaagaaauaacccaaauaucagaucac


ucugagaaacuagcacaugacaccaguauccuuaagagcacucaacagcaaaagccagacucaguaaaaccucugagaacau


gcagaagagugcugagggccucuaaagagguccccaaggaaguguugguggacaccagagaccaugcaacauuacaaagca


aaagcaacccuuugcuguccccgaagaggaagucugcaagagauggaagcauugugagaaccagggcuuugcgcucuuuag


caccaaagcaggaagcaacagaugagaagccuguaccugagaaaaaaagggcugcuuccagcaagagguauguaucaccuga


gccugugaagaugaaacaccugaaaaucgugucaaacaaacuugaaucuguggaagagcagguuagcacuguuaugaaaac


agaagaaauggaagccaaaagagaaaauccugucacuccagaucagaacucuagguaccgaaagaaaaccaauguaaaacagc


caaggcccaaguuugaugcaucugcagagaaugucgggauaaagaaaaacgagaagacuaugaagacugccucccaggagac


agagcugcagaauccagaugauggagccaagaaaucuacaucucggggccaagucagugggaaaagaacaugcuugagguc


uagaggaacgacugagaugccccagccuugugaagcagaagagaaaacaagcaaaccagcugcagaaaucuugauaaagccu


caggaagagaaaggagucucuggagagucugauguuagguguuugagguccagaaaaacuagagucgcuuuggacaguga


accuaagccaaggguaacucguggaaccaagaaagaugcaaaaacucugaaggaggaugaagacauuguaugcaccaagaag


uuaagaacaagaaguuaagaacaagaaguuaccagaaaagugaaacuauguagcaaagacauuuaagaaggaaaaguaaauu


ugacuuagugauaaguuccagugugguuuucaccuccaguguaaagaugaacuguaaauacuacugcuacugccugaguu


uaaggaaggaagcuuugagcuuuccuggucauacucucuucagacgccaauggaggucaugaggaagaucaccagggaucu


cagcgcaauuacaguuuaggggugagcaggcagaaauguggcccucuguccuauccaauaaagcucugaaauucgcugcca


aaa













Cks2/CDC28
 4
gacguagagccccuugcgcccgguuuccugaucccgcuuacuc
271


protein kinase

cucugcgcgccggcaggauggcccacaagcagaucuacuacuc



regulatory

agacaaguacuucgaugagcacuacgaguaccggcaugucaug



subunit 2, sim

uuacccagagaacucucuaaacaaguacccaaaacucaucugau



to cdk

guccgaagaggaguggaggagacuugguguccaacagagucu



regulatory

aggauggguucauuacaugauucaugagccagaaccgcauauu



subunit 2

cuucucuuuagacgaccucuuccaaaagaacaacaaaaaugaa



AA681998

gugcagcugggaucaucuaaucuuuuucaaauuuaauguaua





uguguauauaagguaguauucagugaauacuugaaaagugua





caaaccuuucauccauaccugugcaugcgcuguauucuucaca





gcaacagagcucagucaaaugcaacugcaaguagg






Ccng2/
 3
Sequence below.
272


Cyclin G2





U95826










cuacccuagacaaucacggcuuagccggcgcgcggagucgaucgucucggucgcuagagcuguccugagcucgaacggucc


gacgcccccgccgcgccgguccgugacgccggggccgacacgaugaaggauuugggggccaagcacuuggcagguggcgaa


gggguucagcuuuucggauuguugaacuucuaccuggaacaagaacagagauaccaaccucgggaaaaagggcugaucuug


auggaggcuaccccggagaaugauaacacuuuguguucaagacugagaaaugccaaaguggaagauuuaagaaguuuaacu


aacuucuuuggaucuggcacugaaacuuucguucuggcugucaauauuuuggauagauucuuggcccuuaugaaggugaa


accgaaacaccuguccugcauuggcgucugcugcuuuuugcuggccgccaggcuggcggaagaagaaggugacguuccccc


cacgcacgacgugauccgcaucagucaguguaaaugcacagcgucugacauuaaacgcauggagaaaaucaucucagagaaa


cugcacuaugagcuggaagcuaccacugccuuaaacuuuuugcacuuguaccacgcgauuguauuuugucacacuucagaa


aggaaggagauucucagccucgauaaacucgaagcgcagcugaaagcuugcaacugccgaguugucuucuccaaagcaaga


ccaucuguauuagcucugugccuucucaauuuggaaauagaaacgauaaaauccguggaacugcuggaaauucucuugcuu


guuaaaaaacauuugaagcucagcgacacugaauucuuuuacuggagggaacugguuucuaaaugucuagcagaguauucu


ucgccucgcugcugcaagccugaucugaagaagcugguauggauuguuucgcgacgcacugcgcagaaccuccacagcagc


uacuacaguguuccugagcugcccacuaucccagagggggguugcuuugacggaagugaaagugaggacucuggugaaga


caugaguuguggagaggagagucucagcagcuccccacccagcgaucaggagugcaccuucuucuuugacuuccaaguggc


ucagacacugugcuuuccaccauagaggaaucugacauuguucugugucagggaauuuauaaguguguguaccuagguuu


caaagcaauaaacuuggggguugaauaggguaguuuuccuagguuuccagccccccgucuagucagg













Prc1/Protein
 3
aacuaccuugggcagguucuauuaacugcaccuaacucagacg
273


regulator of

ugaguaggacagaaggaagcugucccgggcgaacugaggucac



cytokinesis 1

aaagacuugcuuuugauucaagagagaccuuaaaggcuaguua



DNA segment,

ugauaguuaaguacaaguuuuaacaucugguagcuaacuuuu



Chr 7

uuucucuaccccguaauucuacuaugacugcucuucuagagg



AA856349

uccugaguucaaaucccagcaaccacaugguggcucacaacca





ucuauaaugggaucugaugcccucuucuggugugc









Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate, contribute significantly to induction of epidermal cells to differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for preventing EDIHN and eliminating hair follicles. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 5 is a method for enhancing EDIHN. In addition, activation of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN.


Example 10
Expression of Wnt-1 Inhibitors During the First Nine Days after Wounding Causes Pigmentation of New HF
Materials and Experimental Methods

In this Example, doubly transgenic mice expressing both tetO-Dkk1 and K5-rtTA were utilized. When these mice are fed chow formulated with 1 g/kg doxycycline (BioServ, Laurel, Md.), they express Dkk1, under the control of the K5 promoter, in the basal epidermis. The control mice also received doxycycline, but they were K5-rtTA negative and thus did not express Dkk1.


Results

A 1 cm2 wound was induced on the lower back of the doubly transgenic mice at 21 days or 50 days old. Mice were placed on doxycycline-containing chow immediately after wounding to induce Dkk1 expression, and then doxycycline was discontinued after completion of the re-epithelialization at 9 days after wounding. Dkk1 expression inhibits Wnt activity, which in turn induces follicle pigmentation. At 22 days after wounding, pigmented HF were observed in the excised skin after preparing the epidermal sheet (FIG. 23A-B). Control mice lacked pigmented HF (FIG. 24).


In other experiments, continued expression of Dkk1 after the 9-day period inhibited formation of new HF.


The findings of this Example show that pigmented HF can be produced by suppressing expression of Wnt or by inducing expression of Dkk1 during the period of re-epithelialization, then inducing expression of Wnt1. In addition, the findings of this Example show that factors that inhibit neonatal hair follicle formation (e.g. Dkk1) also inhibit EDIHN, thus further supporting the notion that hair follicles formed by EDIHN are similar to normal hair follicles.


Example 11
Inhibition of EDIHN by Epidermal Growth Factor Injection

21 day-old mice were wounded as described in previous Examples. Starting from day 11 after wounding, a time point corresponding to the point at which the wound had recently reepithelialized, 10 μL of 1 μg/ml EGF was injected into the wound bed. EGF was injected once per day after this point for a total of 5 days. Three days later, the skin was collected, and whole-mount EDIHN assays were performed. EGF prevented HF formation as assessed by gross morphology. In addition, whole mounts of control and treated skin were analyzed with anti-K17 antibody immunostaining. All mice injected with EGF (n=4) exhibited no new HF formation (FIGS. 25 A-B), while control mice (n=2) had many new HF, as expected. (FIGS. 25 C-D).


In an additional experiment, recombinant EGF (1 microgram (mcg)/microliter (mcl)) was injected at days 11, 13 and 15 after wounding. Skin was collected at 18 days after wounding and stained for K17 and alkaline phosphotase. Once again, administration of EGF inhibited EDIHN.


The findings of this Example show that EGF inhibits HF formation. Thus, inhibiting EGF, EGFR, or one of the pathways in which they participate increases EDIHN-induced HF formation.


Example 12
Enhancement of EDIHN by Inhibition of EGF Receptor

To determine the effect of administration of EGF receptor inhibitors on DIHN, the inhibitor AG1478 (150 μM in 10 μL volume) was administered as a single injection 11 days after incisional wounding (1 cm2) to the middle of the wound near the skin surface. EGF receptor inhibitor administration led to generation of more and larger hair follicles compared with control mice that were wounded only (FIG. 26A). As shown in FIG. 26B, large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing dermal papilla areas.


The findings of this Example confirm the results of the previous Example, and show that more and larger HF can be generated when EDIHN comprises, or is followed by, administration of EGFR inhibitors, or with compounds with a similar mechanism of action; e.g. Hedgehog protein and androgen antagonists.


Example 13
Enhancement of EDIHN by Expression of a β-Catenin Activator

To determine the effect of administration of β-catenin activators on EDIHN, K14-Wnt7 transgenic mice, which overexpress the β-catenin pathway activator, Wnt7, in the epidermis, were subjected to EDIHN, then HF formation was measured 19 days after wounding. In each of 2 separate experiments, with 4 week old and 3 week old mice, the transgenic mice developed significantly larger numbers of HF compared to control, non-transgenic littermate mice (FIG. 27 A-C).


Thus, administration of β-catenin activators leads to an increase in EDIHN. The findings of Examples 11-13 show that new HF can be generated by (a) disrupting the epidermis; and (b) administering a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell.


Example 14
Enhancement of EDIHN by Administration of FGF

To determine the effect of fibroblast growth factor (FGF) on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. FGF administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering FGF, a nucleotide encoding FGF, or a factor that increases signaling by FGF.


Example 15
Enhancement of EDIHN by Administration of Edar

To determine the effect of fibroblast growth factor (FGF) on EDIHN, K14-Eda-A1 transgenic mice, which overexpress (ectodysplasin-A1) Eda-A1 in the epidermis, are subjected to EDIHN, then HF formation is measured 19 days after wounding as described in Example 13. The transgenic mice developed significantly larger numbers of HF compared to control, non-transgenic littermate mice, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering a factor that enhances signaling by ectodysplasin.


Example 16
Enhancement of EDIHN by Administration of Minoxidil

To determine the effect of minoxidil on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. Minoxidil administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering a minoxidil.


Example 17
Removal of HF by Abrasion and Administration of EGF

Hair-bearing regions of the epidermis of mice is abraded, as described in Example 1, then administering recombinant EGF, as described in Example 1. This method prevents hair re-growth in the abraded areas, showing that hair can be removed by (a) disrupting the epidermal layer; and (b) administering EGF, a nucleotide encoding EGF, or a factor that increases signaling by EGF.

Claims
  • 1-37. (canceled)
  • 38. A method for treating baldness or a hair loss condition or for stimulating hair growth in a human subject comprising: (a) wounding an area of the balding scalp of said human subject by disrupting an epidermis or dermis of the area of the balding scalp, thereby creating a wounded area; and (b) contacting the wounded area with a compound or factor that activates a beta-catenin protein or an inhibitor of a protein that suppresses an activity of the beta-catenin protein and minoxidil.
  • 39. The method of claim 38, wherein said wounding is performed with a tool that comprises sandpaper, a laser, a Fraxel laser, a CO2 laser, an excimer laser, a felt wheel, a dermabrasion device, a light-based method, irradiation with visible light, irradiation with infrared light, irradiation with ultraviolet radiation, orthovoltage radiation, xray radiation, a surgical tool, a dermal biopsy punch, or is performed with a burn treatment or chemical treatment.
  • 40. The method of claim 39, wherein said dermabrasion device is a micro-dermabrasion device.
  • 41. The method of claim 38, wherein said wounding is dermabrasion.
  • 42. The method of claim 38, wherein the wounding-step comprises disrupting the epidermis and dermis of the area of the balding scalp.
  • 43. The method of claim 38, in which only part of the epidermis is removed.
  • 44. The method of claim 38, wherein the method further comprises contacting said area of the balding scalp with a precursor cell, an inductive cell, or a hair follicle or a portion thereof.
  • 45. The method of claim 38, wherein the method further comprises contacting said area of the balding scalp with one or more of the following compounds: finasteride, dutasteride, fluridil, spironolactone, cyproterone acetate, bicalutamide, flutamide, nilutamide, an inhibitor of an androgen receptor, an androgen antagonist, or an anti-androgen.
  • 46. The method of claim 45, wherein said wounding-step is performed between 3-12 days, 4-12 days, 5-12 days, 4-11 days, 6-11 days, 6-10 days, 6-9 days, 6-8 days, 7-8 days, 5-11 days, 5-10 days, 7-10 days, or about 1 week prior to said contacting step.
  • 47. The method of claim 38, wherein said area of the balding scalp is subjected to depilation or administration of a retinoid prior to said wounding.
  • 48. The method of claim 47, wherein said depilation is performed by plucking, waxing, abrasion, laser, electrolysis, or administration of thioglycolic acid on said area of the balding scalp.
  • 49. The method of claim 38, wherein said wounded area of the balding scalp is not surgically closed, or not contacted with a bandage, dressing, or ointment that facilitates wound healing for a period of time following said wounding-step.
  • 50. The method of claim 49, wherein said period of time is within about 1 day, about 2 days, about 3 days, about 4 days, about 5 days, about 7 days, about 10 days, about 11 days, about 14 days, about 17 days, or about 3 weeks.
  • 51. The method of claim 38, wherein said wounded area of the balding scalp is allowed to heal by secondary intention.
  • 52. The method of claim 38, wherein the method is performed on a subject with androgenetic alopecia (AGA), scarring alopecia, male pattern baldness, female pattern baldness, discoid lupus erythematosis, or lichen planopilaris.
  • 53. The method of claim 38, wherein said treatment results in an increase in markers of hair follicle proliferation, hair follicle differentiation or hair follicle embryonic development.
  • 54. The method of claim 38, wherein said treatment results in an increase in the amount of pigmented hair or an increase in hair follicle size.
  • 55. The method of claim 38, wherein said treatment results in differentiation of an uncommitted epidermal cell into a hair follicle cell.
  • 56. The method of claim 38, wherein said treatment results in generation of a hair follicle in the scalp of the subject.
  • 57. The method of claim 38, wherein said wounding does not result in bleeding.
  • 58. A method for treating baldness or a hair loss condition or for stimulating hair growth in a human subject comprising: (a) perforating an area of the balding scalp of said human subject, thereby generating a disrupted epidermis or dermis area of the balding scalp; and (b) contacting the disrupted epidermis or dermis area of the balding scalp with a compound or factor that activates a beta-catenin protein or an inhibitor of a protein that suppresses an activity of the beta-catenin protein and minoxidil.
  • 59. The method of claim 38, wherein said compound or factor is a Wnt7 protein or a nucleic acid molecule encoding said Wnt7 protein.
  • 60. The method of claim 38, wherein the step of disrupting said epidermis comprises the disruption of the basal and suprabasal epidermal layers.
CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No. 14/946,512, filed on Nov. 15, 2015, which is a continuation of U.S. patent application Ser. No. 13/327,611, filed on Dec. 15, 2011, which is a continuation of U.S. patent application Ser. No. 11/887,104, filed Sep. 25, 2007, which is a National Phase Application of PCT International Application PCT/US06/11319, filed Mar. 28, 2006, claiming priority to U.S. Provisional Patent Applications 60/665,857 and 60/683,293, filed 29 Mar., 2005, and 23 May, 2005, respectively. Additionally, this application relates to U.S. patent application Ser. Nos. 12/904,822 and 12/904,981, both filed on Oct. 14, 2010. All of the above-identified applications are incorporated by reference herein in their entirety.

Provisional Applications (2)
Number Date Country
60665857 Mar 2005 US
60683293 May 2005 US
Continuations (3)
Number Date Country
Parent 14946512 Nov 2015 US
Child 16222705 US
Parent 13327611 Dec 2011 US
Child 14946512 US
Parent 11887104 Sep 2007 US
Child 13327611 US