Methods for generating new hair follicles, treating baldness, and hair removal

FIELD OF INVENTION

The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

BACKGROUND OF THE INVENTION

Follicular neogenesis is defined as the generation of new hair follicles (HF) after birth. Humans are born with a full complement of HF, which can change in size and growth characteristics as in early baldness or can ultimately degenerate and disappear as in late stages of baldness or in permanent scarring (cicatricial) alopecias. Therefore, the generation of new HF is desirable in the treatment of common baldness as well as less common hair loss conditions, such as discoid lupus erythematosis, congenital hypotrichosis, lichen planopilaris and other scarring alopecias.

SUMMARY OF THE INVENTION

The present invention provides methods of treating baldness in a subject and generating new hair follicles (HF), comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

In one embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region.

In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject.

In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an AGA in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1: Epidermal abrasion results in de novo hair follicle (HF) formation. HF at progressive stages of development are depicted in the left, center, and right panels. The arrow in the left panel indicates a hair germ. The dark stained cells are progeny of HF stem cells in the bulge.

FIG. 2: BrdU labeling of HF following epidermal abrasion. HF at progressive stages of development are depicted in the left, center, and right panels.

FIG. 3. The wound site did not contain HF immediately after re-epithelialization. Top view (left panel) and tissue section (right panel) of the site 10 days after wound induction.

FIG. 4. Appearance of hair germs 12 days after wound induction. Arrow indicates hair germ.

FIG. 5. Epidermal Disruption-Induced HF neogenesis (EDIHN)-induced hair germs express K17. Two different hair germs are depicted in the left and right panels.

FIG. 6. EDIHN-induced hair germs contain dermal papilla (DP) cells, as evidenced by alkaline phosphatase (AP) staining. Arrows indicate DP cells. Left panel: hair germs. Right panel: HF at a further developmental stage.

FIG. 7. Histological comparison between EDIHN-induced and embryonic HF. Top left, second from left, third from left, and right panels: Progressive stages of EDIHN-induced HF development. Bottom left, center, and right panels: Progressive stages of and embryonic HF development.

FIG. 8. Induction of several markers of embryonic HF development, Lef1 (left panel), wingless/int (Wnt) 10b (center panel), and sonic hedgehog (Shh; right panel), by EDIHN. HF structures are indicated by arrowheads.

FIG. 9. Proliferative activity during EDIHN, as evidenced by BrdU pulse-labeling. Progressive stages of HF development are depicted in the left, center, and right panels.

FIG. 10. Induction of HF markers S100A3 (left panel; tissue section parallel to HF axis) and S100A6 (right panel; cross-sectional view of follicle) by EDIHN.

FIG. 11. New hair growth 25 days (left panel) and 45 days (right panel) after wound induction.

FIG. 12. Schematic of whole-mount EDIHN assay.

FIG. 13. Repopulation of stem cells in the bulge of EDIHN-induced HF, as evidenced by retention of BrdU label following a chase period. Left panel: lower magnification: 50×. Right panel: higher magnification: 400×.

FIG. 14. A. Stem cells in EDIHN-induced HF express K15. Left top panel: Top view of wound site. Bottom, far left panel: epidermis whole mount; bottom, second from left panel: same as [bottom, far left] panel but viewed under white light; right panel: tissue sections. B. Neogenesis HF proceed to next hair cycle.

FIG. 15. Schematic of creation of new HF by EDIHN.

FIG. 16. No new HF are evident 11 days after wound induction in 21-day-old mice. Top panel: macroscopic examination; bottom left panel: AP staining of the dermis; bottom right panel: K17 staining of the epidermis.

FIG. 17. 14 days after wound induction, new HF have begun to form as evidenced by AP staining of the dermis (left panel) and K17 staining of the epidermis (right panel). Main panels: 10× magnification. Inserts: 80× magnification.

FIG. 18. 17 days after wound induction, new HF are more developed. Left panel: AP staining of the dermis; right panel: K17 staining of the epidermis. Main panels: 10× magnification. Inserts: 80× magnification.

FIG. 19. Wounds closed similar in mice subjected to depilation, then wounding (left 3 mice in each panel) vs. wounding alone (right 4 mice in each panel). Left panel: immediately following wounding. Right panel: 10 days following wounding.

FIG. 20. Anagen induction by depilation prior to wounding enhances the efficiency of EDIHN. A. Top panel: lower left panel AP staining of the dermis; lower right panel: KI 7 staining of the epidermis. B. Graphical representation of enhancement of EDIHN by depilation.

FIG. 21. A. EDIHN in human skin grafted to immunodeficient (scid) mice, seven days after induction of an excisional wound. Arrows indicate new HF. 13. Dermal abrasion of human skin grafts results in EDIHN. Human adult skin (W) was grafted onto mice, abraded, and examined seven days later, by staining for S100A6 (first, second, and fourth rows) or S100A4 (third row). Hair germs (HG) and dermal papilla (DP) are indicated. Human fetal skin (F) with normal developing hair follicles is shown for comparison. Mouse skin 17d post wounding was included as a control (top left panel).

FIG. 22. Transcripts up-regulated at least 2-fold in activated HF cells, as assessed by dChip analysis. (A). Mean values and standard errors of the up-regulated transcripts in non-activated (“bs-line”) and activated (“expt”) samples and fold-changes and differences between non-activated and activated values are depicted. (B). Raw data for up-regulated transcripts in non-activated and activated cells. “Ctrl” denotes non-activated and “High-dep” denotes activated cells. (C). Additional information about up-regulated transcripts.

FIG. 23. Pigmented hair follicle neogenesis observed in the skin of Dkk1-expressing mice following EDIHN A. 3.2× magnification. B. 8× magnification.

FIG. 24. Control mice lacked pigmented HF.

FIG. 25. EGF inhibits HF formation by EDIHN. A. K17 staining of wounded skin of representative mouse treated with EGF. Magnification is 4×. B. High magnification view (10×) of skin depicted in (A). C. K17 staining of wounded skin of representative control mouse that received no EGF after wounding. Magnification is 4×. D. Higher magnification view (10×) of skin depicted in (D).

FIG. 26. Administration of an EGF receptor inhibitor (AG1478) leads to generation of more and larger HF compared with controls. A. Top: skin of 2 control mice. Outer dashed line indicates the extent of the wounded area after contraction and healing; inner dashed line indicates the area of neogenesis. Bottom: skin of 2 treated mice, in which the wounded area and area of neogenesis largely coincide, with the exception of a small area on the left side of the encircled area in each panel. B. Large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing DP areas. Scale Bars: 200 μm.

FIG. 27. A. Increased hair follicle formation in K14-Wnt7a mice. Left panel: Wnt7a transgenic mice. Right panel: control (wild-type) mice. B. Quantiation of experiment with 4 week old mice. C. Quantiation of experiment with 3 week old mice

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides methods of treating baldness in a subject and generating new HF, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

In one embodiment, the present invention provides a method for generating a hair follicle (HF) in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for generating a new HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a new HF in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for increasing the number of HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing the number of HF in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor.

In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor.

In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the compound or factor.

In another embodiment, the present invention provides a method for increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, the factor is an inhibitor of an EGF protein or an EGFR. In another embodiment, the factor is a Hedgehog protein, a nucleotide encoding same or an activator of same. In another embodiment, the factor is an androgen antagonist. In another embodiment, the factor is any other compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell. Each possibility represents a separate embodiment of the present invention.

The precursor cell of methods and compositions of the present invention, is, in another embodiment, a HF stem cell. In another embodiment, the precursor cell is an epidermal cell. In another embodiment, the precursor cell is a dermal papilla cell. In another embodiment, the precursor cell is a connective tissue sheath cell. In another embodiment, the precursor cell is any other type of cell known in the art that is capable of differentiation into a hair follicle cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the inductive cell is a mesenchymal cell. In another embodiment, the inductive cell is any other type of inductive cell enumerated herein. In another embodiment, the inductive cell is any other type of inductive cell known in the art. Each possibility represents a separate embodiment of the present invention.

“Contacting” as used herein refers, in another embodiment, to bringing the scalp, eyebrow, etc, into to contact with the compound, factor, cell, etc. In another embodiment, the term refers to embedding the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, the term refers to injecting the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, term refers to any other type of contacting known in the art. Each possibility represents a separate embodiment of the present invention.

“Promotes a differentiation” refers, in another embodiment, to the act of increasing the percentage of cells that will differentiate as indicated. In another embodiment, the term refers to increasing the number of cells per unit area of skin that will differentiate. In another embodiment, the promoter of differentiation is active in the milieu of the skin. Each possibility represents a separate embodiment of the present invention.

“Uncommitted epidermal cell” refers, in another embodiment, to an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is a bulge-derived cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF cell.

The “HF cell” that results from the differentiation is, in another embodiment, an HF stem cell. In another embodiment, the HF cell is a dermal papilla cell. In another embodiment, the HF cell is a bulb cell. In another embodiment, the HF cell is a matrix cell. In another embodiment, the HF cell is a hair shaft cell. In another embodiment, the HF cell is an inner root sheath cell. In another embodiment, the HF cell is an outer root sheath cell. In another embodiment, the HF cell is a melanocyte stem cell. In another embodiment, the HF cell is a melanocyte. Each type of uncommitted epidermal cell and HF cell represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is administed in a solution. In another embodiment, the compound or factor is administed in a cream. In another embodiment, the compound or factor is administed in an ointment. In another embodiment, the compound or factor is administed in a slow release formulation. In another embodiment, the compound or factor is administed in a liposome encapsulated formulation. In another embodiment, the compound or factor is directly injected. In another embodiment, the compound or factor is administed by any other method known in the art. Each possibility represents a separate embodiment of the present invention.

The compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is, in another embodiment, an inhibitor of an Epidermal Growth Factor (EGF). In another embodiment, the compound or factor is an inhibitor of an EGF receptor. Each possibility represents a separate embodiment of the present invention.

As provided herein (Example 11), activating one or more pathways in which EGF is involved (by injection of EGF) blocks the formation of HF. Thus, antagonizing the pathway increases HF formation, as demonstrated in Example 12.

In another embodiment, the inhibitor of an EGF or an EGF receptor is panitumumab. In another embodiment, the inhibitor is AG1478. In another embodiment, the inhibitor is nimotuzumab. In another embodiment, the inhibitor is an antibody that binds EGF or EGFR. In another embodiment, the inhibitor is HuMax-EGFR® (Genmab, Copenhagen, Denmark). In another embodiment, the inhibitor is cetuximab. In another embodiment, the inhibitor is IMC 11F8. In another embodiment, the inhibitor is matuzumab. In another embodiment, the inhibitor is SC 100. In another embodiment, the inhibitor is ALT 110. In another embodiment, the inhibitor is PX 1032. In another embodiment, the inhibitor is BMS 599626. In another embodiment, the inhibitor is MDX 214. In another embodiment, the inhibitor is PX 1041. In another embodiment, the inhibitor is any other inhibitor of an EGF or an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an inhibitor of a tyrosine kinase activity of an EGF receptor. In another embodiment, the inhibitor is gefitinib. In another embodiment, the inhibitor is erlotinib. In another embodiment, the inhibitor is canertinib. In another embodiment, the inhibitor is leflunomide. In another embodiment, the inhibitor is A77 1726. In another embodiment, the inhibitor is pelitinib. In another embodiment, the inhibitor is ZD 1839. In another embodiment, the inhibitor is CL 387785. In another embodiment, the inhibitor is EKI 785. In another embodiment, the inhibitor is vandetanib. In another embodiment, the inhibitor is any other inhibitor of a tyrosine kinase activity of an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the EGF or EGFR antagonist is a carboxypeptidase inhibitor from potato (PCI) protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a sprouty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an Argos protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a lefty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an antibody that recognizes EGF or EGFR, or a fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is small molecule inhibitor that binds and reduces the activity of EGF or EGFR. In another embodiment, the EGF or EGFR antagonist is CRM197. In another embodiment, the EGF or EGFR antagonist is IMC-C225 (ImClone Systems, New York, N.Y.). In another embodiment, the EGF or EGFR antagonist is any other antagonist of EGF or EGFR known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor.

In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor.

In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the inhibitor of an EGF protein or an EGF receptor.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a β-catenin protein. In another embodiment, the compound or factor is a nucleotide that encodes a β-catenin protein. In another embodiment, the compound or factor is an activator of a β-catenin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the β-catenin protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the β-catenin protein, nucleotide, compound or factor.

In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the β-catenin protein, nucleotide, compound or factor.

In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the β-catenin protein, nucleotide, compound or factor.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a fibroblast growth factor (FGF) protein. In another embodiment, the compound or factor is a nucleotide that encodes an FGF protein. In another embodiment, the compound or factor is an FGF receptor. In another embodiment, the compound or factor is a nucleotide that encodes an FGF receptor. In another embodiment, the compound or factor is an activator of an FGF protein. In another embodiment, the compound or factor is an activator of FGF receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the FGF protein or FGF receptor. In another embodiment, the protein that is inhibited is an FGF binding protein. In another embodiment, the protein that is inhibited is FGF-bp1. Each possibility represents a separate embodiment of the present invention.

Is provided herein, FGF and its receptor are upregulated, under the conditions utilized herein, upon HF stem cell differentiation (Example 9). Moreover, FGF-bp1 is downregulated, under the conditions utilized herein, upon HF stem cell differentiation. Thus, FGF and its receptor promote differentiation of uncommitted epidermal cells into HF cells.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an ectodysplasin protein (referred to, in another embodiment, as “eda”; in another embodiment, as “ectodermodysplasin protein.”) In another embodiment, the ectodysplasin protein is Eda-A1. In another embodiment, the compound or factor is an ectodysplasin receptor (referred to, in another embodiment, as “edar”). In another embodiment, the compound or factor is an activator of an ectodysplasin protein. In another embodiment, the compound or factor is an activator of an ectodysplasin receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the ectodysplasin protein or ectodysplasin receptor. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the eda protein of methods and compositions of the present invention has the sequence:

MGYPEVERRELLPAAAPRERGSQGCGCGGAPARAGEGNSCLLFLGFFGLSLALHLLTLCC YLELRSELRRERGAESRLGGSGTPGTSGTLSSLGGLDPDSPITSHLGQPSPKQQPLEPGEAAL HSDSQDGHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGPP GPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGTR ENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIY SQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKM VHADISINMSKHTTFFGAIRLGEAPAS (GenBank Accession No: NM_—001399; SEQ ID No: 274). In another embodiment, the eda protein has a sequence selected from the sequences set forth in GenBank entries NM_—001005609, NM_—001005610, NM_—001005611, NM_—001005612, NM_—001005613, NM_—001005614, NM_—001005615, AF040628, AF061194, AF061193, AF061192, AF061191, AF061190, AF061189, and AF060999. In another embodiment, the eda protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an Eda protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the edar protein of methods and compositions of the present invention has the sequence:

MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPYLS CGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLP GYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAHKELS GQGHLATALIIAMSTIFIMAIAIVLIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKKEAP DNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLLS LVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRMLS STYN SEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRIS TAGYSIPELLTKLVQIERLDAVES LCADILEWAGVVPPASQPHAAS (GenBank Accession No: BC093872; SEQ ID No: 275). In another embodiment, the edar protein has a sequence selected from the sequences set forth in GenBank entries BC093870; BC034919; NM_—021783; NM_—022336; AY152724; AF298812; AH008077; AF130996; AF130988. In another embodiment, the edar protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an Edar protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Noggin protein. In another embodiment, the compound or factor is a nucleotide encoding a Noggin protein. In another embodiment, the compound or factor is an activator of a Noggin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the Noggin protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the Noggin protein of methods and compositions of the present invention has the sequence:

MERCPSLGVTLYALVVVLGLRATPAGGQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNE TLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLE FSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRS CSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC (GenBank Accession No: NM_—005450; SEQ ID No: 276). In another embodiment, the Noggin protein has a sequence selected from the sequences set forth in GenBank entries BC034027 and U31202. In another embodiment, the Noggin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Noggin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a Hedgehog protein. In another embodiment, the compound or factor is an activator of a Hedgehog protein. In another embodiment, the compound or factor is a sonic Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a sonic Hedgehog protein. In another embodiment, the compound or factor is an activator of a sonic Hedgehog protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the Hedgehog protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. NM_—000193. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries L38518 and NP_—000184. In another embodiment, the Hedgehog protein has any other Hedgehog sequence known in the art. In another embodiment, the Hedgehog protein has any other sonic Hedgehog sequence known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Transforming Growth Factor (TGF)-beta1 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta1 protein. In another embodiment, the compound or factor is an activator of a TGF-beta1 protein. In another embodiment, the compound or factor is a TGF-beta3 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta3 protein. In another embodiment, the compound or factor is an activator of a TGF-beta3 protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta1 protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta3 protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the TGF-beta1 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. BC000125. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries BC001180, BC022242, and NM_—000660. In another embodiment, the TGF-beta1 protein has any other TGF-beta1 sequence known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the TGF-beta3 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. J03241. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries NM_—003239, BC018503, BT007287 and X14149. In another embodiment, the TGF-beta3 protein has any other TGF-beta3 sequence known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell acts directly on the uncommitted epidermal cell. In another embodiment, the compound or factor acts on the uncommitted epidermal cell via a mesenchymal cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the mesenchymal cell is a dermal condensate cell. In another embodiment, the mesenchymal cell is a DP cell. In another embodiment, the mesenchymal cell is another cell type or differentiation stage in the dermal condensate-DP lineage. In another embodiment, the mesenchymal cell is any other type of mesenchymal cell known in the art. Each possibility represents a separate embodiment of the present invention.

The EGFR of methods and compositions of the present invention has, in another embodiment, the sequence:

MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVL SNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQN HLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTG PRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVV TDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKN CTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEII RGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKT KIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREF VENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWK YADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMR RRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLW IPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMP FGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKI TDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGS KPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQ RYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSS LSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKR PAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQ KGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA (GenBank Accession No: NM_—005228; SEQ ID No: 277). In another embodiment, the EGFR has a sequence selected from the sequences set forth in GenBank entries NM_—201282, NM_—201283, NM_—201284, BC094761, AF288738, AY588246, AY573061, X17054, AF125253, U48722, K03193, and AY698024. In another embodiment, the EGFR is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an EGFR is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

The EGF of methods and compositions of the present invention has, in another embodiment, the sequence:

MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTN YEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINW INEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWS SEVAGSLYRADL DGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKIIPTQHNL FAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDT WEPEQKLCKLRKGNCSSTVCGQDLQ SHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTL GCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLER DGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDI RHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEE GVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFW TDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRR LTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPL AKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDL KNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQC LKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLG VHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHD GYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVC VVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWFV VIKEHQDLKNGGQPVAGEDGQAADGSMQPTS WRQEPQLCGMGTEQGCWIPVSSDKGSCP QVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ (GenBank Accession No: NM_—001963; SEQ ID No: 278). In another embodiment, the EGF has a sequence selected from the sequences set forth in GenBank entries BC093731, AY548762, and X04571. In another embodiment, the EGF is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an EGF is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

The beta-catenin protein of methods and compositions of the present invention has, in another embodiment, the sequence:

MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDT SQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHP TNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLS KKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAWKSGGIPAL VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGG MQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAG ILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQN AVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQ DTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIE NIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQD YKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALG MDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL (GenBank Accession No: NM_—001904; SEQ ID No: 279). In another embodiment, the beta-catenin protein has a sequence selected from the sequences set forth in GenBank entries BC058926, X87838, AF130085, AB062292, Z19054, and NP_—001895. In another embodiment, the beta-catenin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a beta-catenin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

The Wnt protein of methods and compositions of the present invention has, in another embodiment, the sequence:

MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGE GSQMGLDECQFQFRNGRNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACT QGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLH NNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRA SRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGC DLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK (GenBank Accession No: BC008811; SEQ ID No: 280). In another embodiment, the Wnt protein has a sequence selected from the sequences set forth in GenBank entries NM_—004625, D83175, U53476, and NP_—004616. In another embodiment, the Wnt protein is a Wnt7 protein. In another embodiment, the Wnt protein is a Wnt7a protein. In another embodiment, the Wnt protein is Wnt1 protein. In another embodiment, the Wnt protein is a Wnt3 protein. In another embodiment, the Wnt protein is a Wnt3a protein. In another embodiment, the Wnt protein is a Wnt10 protein. In another embodiment, the Wnt protein is a Wnt10a protein. In another embodiment, the Wnt protein is a Wnt10b protein. In another embodiment, the Wnt protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Wnt protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7 protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7a protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by a ribonucleic acid (RNA) molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. Each possibility represents a separate embodiment of the present invention.

As provided herein, the transcripts depicted in Table 3 (Example 8; SEQ ID No: 1-232), the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, under the conditions utilized herein, anagen can be induced by activation of these transcripts, proteins, and pathways. Activation of the transcripts, proteins, and pathways depicted in Table 3 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-257. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. Each possibility represents a separate embodiment of the present invention.

As provided herein, the transcripts depicted in Table 4 (Example 9; SEQ ID No: 233-257), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, under the conditions utilized herein, to induction of epidermal cells to differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that decreases an activity of a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 258-273. In another embodiment, the compound or factor decreases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 258-273. Each possibility represents a separate embodiment of the present invention.

As demonstrated by findings of the present invention, the transcripts depicted in Table 5 (Example 9; SEQ ID No: 258-273), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, under the conditions utilized herein, to preventing induction of epidermal cells to differentiate into HF stem cells. Inhibition of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN. In another embodiment, inhibition of these transcripts, proteins, and pathways represents a method for induction of hair growth in a subject.

In one embodiment, the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-273 or the nucleic acid encoding same is administered before the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232 or the nucleic acid encoding same. In another embodiment, the two compounds are administered simultaneously. Each possibility represents a separate embodiment of the present invention.

In one embodiment, a protein encoded by an RNA sequence selected from SEQ ID No: 1-273, or a compound that modulates the protein, is administered before other proteins encoded by same or compounds that modulate them, in order to further enhance their effect in generating an HF or stimulating hair growth. In another embodiment, the wnt pathway is stimulated before the hedgehog pathway. In another embodiment, the two pathways are stimulated in an overlapping fashion. In another embodiment, the two pathways are stimulated simultaneously. Each possibility represents a separate embodiment of the present invention.

In another embodiment, activating or decreasing expression of an RNA transcript in methods of the present invention occurs via a transcription mechanism (e.g. activation of expression of the RNA). In another embodiment, activating or decreasing expression of the RNA transcript occurs via a translational mechanism. In another embodiment, activating or decreasing expression of the RNA transcript occurs via a post-translational mechanism. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the nucleic acid molecule utilized in methods of the present invention is a deoxyribonucleic acid (DNA) molecule that encodes an RNA molecule having a sequence selected from the sequences set forth in the present invention.

In one embodiment, an RNA molecule of the present invention encodes a protein that plays a role in HF regeneration. In another embodiment, the RNA molecule is itself catalytically active, e.g., a ribozyme, etc. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that promotes placodal cell fate. As provided herein, factors that promote placodal cell fate enhance EDIHN, as exemplified in the Examples herein. In another embodiment, the compound or factor acts at the placode stage of HF development.

In another embodiment, the compound or factor inhibits a biological factor that inhibits a differentiation of an uncommitted epithelial cell into an HF cell.

In another embodiment of methods and compositions of the present invention, a composition comprising one of the above compounds or factors is administered. Each of the above types of compounds, factors, and compositions represents a separate embodiment of the present invention.

In one embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.

In one embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby treating baldness in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for an HF in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the minoxidil.

In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the minoxidil.

In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject.

In another embodiment, the present invention provides a method for hair removal from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing hair from a skin or scalp of a subject. In another embodiment, the epidermal disruption is light dermabrasion. In another embodiment, the epidermal disruption is a non-scarring method. In another embodiment, administration of the EGF protein, EGF receptor, nucleotide, compound, or factor suppresses HF formation. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within several days of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within about 1 day of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered according to any of the timing embodiments enumerated herein for Dkk1 protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a use of either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, for the preparation of a pharmaceutical composition for use in a method for removal of an HF from a skin or scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the EGF protein, EGF receptor, nucleotide, compound, or factor.

In another embodiment, a composition or method of the present invention is utilized on human skin. In another embodiment, the composition or method is utilized on an area of unwanted hair growth. In another embodiment, the area is the face. In another embodiment, the area is the bikini area. In another embodiment, the area is the legs. In another embodiment, the area is the arms. In another embodiment, the area is the chest.

An “inhibitor” utilized in methods and compositions of the present invention is, in another embodiment, an antibody that binds the protein or biological factor that is the target of the inhibitor. In another embodiment, the inhibitor is a pharmacologic inhibitor. In another embodiment, the inhibitor is any other type of inhibitor known in the art. Each possibility represents a separate embodiment of the present invention.

The step of disrupting the epidermis in methods of the present invention is performed, in another embodiment, by abrading the scalp, eyebrow, or scarred region. In another embodiment, the term “abrading” refers to an act of creating an abrasion. In another embodiment, “abrading” refers to rubbing. In another embodiment, “abrading” refers to wearing away by friction. As provided herein (Example 1), epidermal abrasion causes, under the conditions utilized herein, de novo HF neo-genesis. In another embodiment, the epidermal layer is disrupted.

In one embodiment, “abrasion” has the same meaning as “abrading.” In another embodiment, “abrasion” refers to an area of the scalp or skin from which the epidermis is removed. In another embodiment, “abrasion” refers to an area of the scalp or skin from which the epidermis and dermis are removed. Each definition of “abrading” and “abrasion” represents a separate embodiment of the present invention.

As provided herein, under the conditions utilized, epidermal disruption by a method of the present invention converts the skin back, in another embodiment, to an embryonic-like state, in which the follicle regenerates. In another embodiment, a subsequent window of opportunity is created, during which the number and size of new HF in the skin can be manipulated. In another embodiment, the administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell during this window causes regeneration of larger and more numerous HF. The morphology of HF in abraded skin is similar to that of embryonic HF (Example 1-2 and subsequent Examples), and the markers expressed are similar as well.

In another embodiment, the present invention provides a method of stimulating hair growth in a scalp, eyebrow, or scarred region of a subject, comprising performing a method of present invention, thereby stimulating hair growth in a scalp, eyebrow, or scarred region of a subject. As demonstrated in Example 3, EDIHN-induced HF are capable of generating hairs. Thus, methods of the present invention can be used to stimulate hair growth.

“EDIHN,” in another embodiment, refers to HF neogenesis induced by disruption of the epithelial layer. In another embodiment, the term refers to HF neogenesis induced by abrasion. In another embodiment, the term refers to HF neogenesis induced by wounding. In another embodiment, the term refers to HF neogenesis induced by disruption of the epithelial layer, followed by administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method of testing an ability of a compound to modulate HF generation in vivo, comprising (a) disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; (b) measuring a first HF generation in the first scalp, eyebrow, or scarred region; (c) disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, wherein the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of the first subject or a second subject, whereby the second scalp, eyebrow, or scarred region has not been contacted with the compound; (d) measuring a second HF generation in the second scalp, eyebrow, or scarred region; and (e) comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound modulates an HF generation in vivo (Examples).

In another embodiment, the present invention provides a method of testing an ability of a compound to stimulate hair growth in vivo, comprising disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; measuring a first HF generation in the first scalp, eyebrow, or scarred region; disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, whereby the second scalp, eyebrow, or scarred region has not been contacted with the compound; measuring a second HF generation in the second scalp, eyebrow, or scarred region; and comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound stimulates a hair growth in vivo.

In one embodiment, the methods of the present invention of testing a compound are repeated using a plurality of subjects, until a statistically significant sample has been tested.

In another embodiment of methods for testing compounds of the present invention, the first scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a first subject. In another embodiment, the subject is a subject in need of generation of a new HF. The second scalp, eyebrow, or scarred region, in another embodiment, is a scalp, eyebrow, or scarred region of the first subject. In another embodiment, the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a second subject. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the excisional wounds of methods of the present invention are created using a surgical tool. In one embodiment, the surgical tool is a dermal biopsy punch (Example 2). In another embodiment, the excisional wounds are induced by freezing or cryoinjury. The use of freezing or cryoinjury is well known in the art, and is used, for example by dermatologists to injure skin. In one embodiment, the freezing or cryoinjury results in a blister. In another embodiment, the blister is used as a “chamber” to introduce drugs and or cells into the reepithelialized area. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the excisional wounds of methods of the present invention are not surgically closed. In another embodiment, the excisional wounds are not contacted with a bandage or dressing before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are not contacted with an ointment before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are allowed to heal by secondary intention. Each possibility represents a separate embodiment of the present invention.

The subject of methods of the present invention, is, in another embodiment, a human. As provided herein (Example 7) human skin responds to EDIHN in the same manner as mouse skin. In another embodiment, the subject is a male. In another embodiment, the subject is a female. In another embodiment, the subject is any other type of subject known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the subject is an adult. In one embodiment, “adult” refers to an age greater than about 18 years. In another embodiment, “adult” refers to an age greater than about 20 years. In another embodiment, “adult” refers to an age greater than about 25 years. In another embodiment, “adult” refers to an age greater than about 30 years. In another embodiment, “adult” refers to an age greater than about 35 years. In another embodiment, “adult” refers to an age greater than about 40 years. In another embodiment, “adult” refers to an age greater than about 45 years.

In another embodiment, the subject is elderly. In one embodiment, “elderly” refers to an age greater than about 45 years. In another embodiment, “elderly” refers to an age greater than about 50 years. In another embodiment, “elderly” refers to an age greater than about 55 years. In another embodiment, “elderly” refers to an age greater than about 60 years. In another embodiment, “elderly” refers to an age greater than about 65 years. In another embodiment, “elderly” refers to an age greater than about 70 years.

In another embodiment, the first subject, or, where applicable, both the first subject and the second subject, is a laboratory animal. In another embodiment, the subject(s) is/are mice. In another embodiment, the subject(s) is/are rats. In another embodiment, the subject(s) is/are gerbils. In another embodiment, the subject(s) is/are hamsters. In another embodiment, the subject(s) is/are guinea pigs. In another embodiment, the subject(s) is/are rabbits. In another embodiment, the subject(s) is/are pigs. In another embodiment, the subject(s) is/are dogs. In another embodiment, the subject(s) is/are cats. In another embodiment, the subject(s) is/are primates. In another embodiment, the subject(s) is/are any other laboratory animal known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the subject(s) has a disease or disorder comprising balding. In another embodiment, the subject(s) does not have a disease or disorder comprising balding. In another embodiment, the disease or disorder is androgenetic alopecia (AGA). In another embodiment, the disease or disorder is male pattern baldness. In another embodiment, the disease or disorder is female pattern baldness. In another embodiment, the disease or disorder is a discoid lupus erythematosis. In another embodiment, the disease or disorder is a congenital hypotrichosis. In another embodiment, the disease or disorder is a lichen planopilaris. In another embodiment, the disease or disorder is a scarring alopecia. In another embodiment, the disease or disorder is any other disease or disorder comprising balding known in the art.

In another embodiment, the scalp, eyebrow, or scarred region(s) has a majority of HF in the telogen stage of the hair cycle. The findings of Examples 5-6 show that (a) EDIHN can restore hair growth to the scalp, eyebrow, or scarred region at the telogen stage; and (b) the efficiency of EDIHN at the telogen stage can be enhanced by depilation prior to abrasion or wound induction. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 60% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 70% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 80% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 90% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) does not have a majority of HF in the telogen stage of the hair cycle. Each possibility represents a separate embodiment of the present invention.

In another embodiment of methods and compositions of the present invention, the first step (e.g. epithelial disruption) is performed 3-12 days prior to the second step (e.g. addition of an active compound, factor, cell, etc). In another embodiment, the interval is 4-12 days. In another embodiment, the interval is 5-12 days. In another embodiment, the interval is 4-11 days. In another embodiment, the interval is 6-11 days. In another embodiment, the interval is 6-10 days. In another embodiment, the interval is 6-9 days. In another embodiment, the interval is 6-8 days. In another embodiment, the interval is 7-8 days. In another embodiment, the interval is 5-11 days. In another embodiment, the interval is 5-10 days. In another embodiment, the interval is 7-10 days. In another embodiment, the interval is about 1 week. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of suppressing an activity or expression of a Wnt protein in the scalp, eyebrow, or scarred region. As provided herein, suppressing Wnt activity induces pigmentation in HF generated by methods of the present invention. In another embodiment, the step of suppressing Wnt activity or expression is performed within about 10 days of epidermal disruption. In another embodiment, the step of suppressing Wnt activity or expression is performed prior to the second step (e.g prior to addition of a compound or factor that promotes HF cell differentiation. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for inducing pigmentation of a hair, comprising suppressing expression of a Wnt protein in a follicle of the hair. In another embodiment, the Wnt protein is Wnt1. In another embodiment, the Wnt protein is a Wnt7. In another embodiment, the Wnt protein is a Wnt7a. In another embodiment, the Wnt protein is a Wnt3. In another embodiment, the Wnt protein is a Wnt3a. In another embodiment, the Wnt protein is a Wnt10. In another embodiment, the Wnt protein is a Wnt10a. In another embodiment, the Wnt protein is any other Wnt protein known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for inducing growth of a pigmented scalp hair or eyebrow of a subject, comprising generating a hair follicle in the scalp, eyebrow, or scarred region according to a method of the present invention and suppressing expression of a Wnt protein in the hair follicle, thereby inducing a growth of a pigmented scalp hair or eyebrow of a subject.

In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of a Dkk1 protein. In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of any other Wnt inhibitor known in the art. In another embodiment, the step of suppressing expression of a Wnt protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of inducing expression of a Dkk1 protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed at the time of epidermal disruption. In another embodiment, the step of inducing expression of a Dkk1 protein is performed at the time of epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed several days before generation of the follicle. In another embodiment, the step of inducing expression of a Dkk1 protein several days before generation of the follicle. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 8 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 8 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 9 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 9 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 10 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 10 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 12 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 12 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed during the period of re-epithelialization. In another embodiment, the step of inducing expression of a Dkk1 protein is performed during the period of re-epithelialization. In another embodiment, expression of a Dkk1 protein is halted after several days. In another embodiment, halting expression of Dkk1 protein after several days induces, or enables induction of Wnt protein expression. In another embodiment, the expression of a Wnt protein is induced about 9 days after the abrating or wounding. In another embodiment, the expression of a Wnt protein is induced following the period of re-epithelialization. In another embodiment, induction of Wnt protein expression is necessary for formation of new HF. Each possibility represents a separate embodiment of the present invention.

In another embodiment, “several” refers to about 1 day. In another embodiment, “several” refers to about 2 days. In another embodiment, “several” refers to about 3 days. In another embodiment, “several” refers to about 5 days. In another embodiment, “several” refers to about 7 days. In another embodiment, “several” refers to about 10 days. In another embodiment, “several” refers to about 12 days. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the step of contacting in methods of the present invention comprises directly contacting the scalp, eyebrow, or scarred region with the compound, RNA, protein, etc. In another embodiment, the step of contacting comprises indirectly contacting the scalp, eyebrow, or scarred region via contacting another site or tissue of the subject, after which the compound, RNA, or protein is transported to the scalp, eyebrow, or scarred region by a biological process; e.g, diffusion, active transport, or circulation in a fluid such as the blood, lymph, interstitial fluid, etc. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption in methods of the present invention further removes dermal tissue from the scalp, eyebrow, or scarred region. In another embodiment, the epidermal disruption does not remove dermal tissue from the scalp, eyebrow, or scarred region. Each possibility represents a separate embodiment of the present invention.

“Disrupting” an epidermis or epidermal layer refers, in another embodiment, to removing part of the epidermis or epidermal layer. In another embodiment, the term refers to disturbing the intactness of the epidermis or epidermal layer. In another embodiment, the term refers to perforating the epidermis or epidermal layer. In another embodiment, only part of the epidermal layer need be removed. In another embodiment, the entire epidermal layer is removed. In another embodiment, the term refers to abrading the epidermis or epidermal layer (Examples). In another embodiment, the term refers to wounding the epidermis or epidermal layer (Examples). Each possibility represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption is performed with a tool that comprises sandpaper. In another embodiment, the epidermal disruption is performed with a laser. In another embodiment, the laser is a Fraxel laser. In another embodiment, the laser is a CO₂laser. In another embodiment, the laser is an excimer laser. In another embodiment, the laser is any other type of laser capable of inducing trans-epithelial injury. In another embodiment, the epidermal disruption is performed with a felt wheel. In another embodiment, the epidermal disruption is performed with a surgical tool. In another embodiment, the epidermal disruption is performed with any other tool known in the art that is capable of epidermal disruption. In another embodiment, the epidermal disruption comprises use of a micro-dermabrasion device. In another embodiment, the epidermal disruption comprises a burn treatment.

In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and a disruption of an interfollicular region of said epidermis. In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and does not comprise a disruption of an interfollicular region of said epidermis. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption comprises a light-based method. In another embodiment, the epidermal disruption comprises irradiation with visible light. In another embodiment, the epidermal disruption comprises irradiation with infrared light. In another embodiment, the epidermal disruption comprises irradiation with ultraviolet radiation. In another embodiment, the epidermal disruption comprises orthovoltage irradiation. In another embodiment, the epidermal disruption comprises X-ray irradiation. In another embodiment, the epidermal disruption comprises any other type of irradiation known in the art.

In another embodiment, the epidermal disruption is performed by mechanical means. In another embodiment, “mechanical means” refers to abrading. In another embodiment, the term refers to wounding. In another embodiment, the term refers to ultrasound. In another embodiment, the term refers to radio-frequency. In another embodiment, the term refers to ab electrical process or the use of an electrical current. In another embodiment, the term refers to electoporation. In another embodiment, the term refers to exision. In another embodiment, the term refers to tape-stripping. In another embodiment, the term refers to microdermabrasion. In another embodiment, the term refers to the use of peels. In another embodiment, the term refers to any other type of mechanical means known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption comprises chemical treatment. In another embodiment, the chemical is phenol. In another embodiment, the chemical is trichloracetic acid. In another embodiment, the chemical is ascorbic acid. In another embodiment, the chemical is any other chemical capable of epidermal disruption that is known in the art.

Each method or type of method of epidermal disruption represents a separate embodiment of the present invention.

In another embodiment, epidermal trauma is utilized in a method of the present invention.

Each type of epidermal abrasion and epidermal trauma represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption of methods of the present invention creates an abrasion at least about 1-1.5 centimeters (cm) in width. In another embodiment, the abrasion is at least about 1 cm in width. In another embodiment, the abrasion is at least about 1.5 cm in width. In another embodiment, the abrasion is at least about 2 cm in width. Each type of abrasion represents a separate embodiment of the present invention.

In another embodiment, the scalp, eyebrow, or scarred region is not contacted with a bandage or dressing following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is not contacted with an ointment following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to facilitate healing. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to prevent infection. In another embodiment, the period of time is the time it takes the epidermal disruption to heal. In another embodiment, the period of time is any time or range of times between 2 days and 3 weeks. Each possibility represents a separate embodiment of the present invention.

In one embodiment, “following” refers to a period of time of about 2 days. In another embodiment, “following” refers to a period of time of about 3 days. In another embodiment, “following” refers to a period of time of about 4 days. In another embodiment, “following” refers to a period of time of about 5 days. In another embodiment, “following” refers to a period of time of about 7 days. In another embodiment, “following” refers to a period of time of about 10 days. In another embodiment, “following” refers to a period of time of about 2 weeks. In another embodiment, “following” refers to a period of time of about 3 weeks. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of depilating the scalp, eyebrow, or scarred region. As provided herein, the findings of Example 6 show that the efficiency of EDIHN can be enhanced by depilation prior to abrasion or wound induction.

In another embodiment, the depilation is epilation. In another embodiment, the depilation comprises the step of waxing. In another embodiment, the depilation comprises the step of plucking. In another embodiment, the depilation comprises the use of an abrasive material. In another embodiment, the depilation comprises the use of a laser. In another embodiment, the depilation comprises the use of electrolysis. In another embodiment, the depilation comprises the use of a mechanical device. In another embodiment, the depilation comprises the use of thioglycolic acid. In another embodiment, the depilation comprises the use of any other method of depilation or epilation known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of administering a topical retinoid to the scalp, eyebrow, or scarred region. In one embodiment, the topical retinoid induces resting (telogen) HF in the scalp, eyebrow, or scarred region to enter anagen. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the additional step (depilation or administration of a retinoid) is performed prior to the step of disrupting the epidermis. In another embodiment, the additional step is performed following the step of disrupting the epidermis, but prior to the addition of the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. In another embodiment, the additional step is performed concurrently with the addition of the differentiation-promoting compound or factor. In another embodiment, the additional step is performed following the addition of the differentiation-promoting compound or factor. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the additional step is performed between about two days and about three weeks before the step of abrading. In another embodiment, the additional step is performed about two days before the step of abrading. In another embodiment, the additional step is performed about three days before the step of abrading. In another embodiment, the additional step is performed about four days before the step of abrading. In another embodiment, the additional step is performed about one week before the step of abrading. In another embodiment, the additional step is performed about ten days before the step of abrading. In another embodiment, the additional step is performed about two weeks before the step of abrading. In another embodiment, the additional step is performed about three weeks before the step of abrading. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the methods of the present invention further comprise the step of contacting the scalp, eyebrow, or scarred region with an inductive cell capable of inducing an epidermal cell to differentiate into an HF cell. In another embodiment, the HF cell is an HF stem cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the inductive cell is a dermal papilla cell. In another embodiment, the inductive cell is a follicular papilla cell. In another embodiment, the inductive cell is a dermal sheath cell. In another embodiment, the inductive cell is a cell that has been genetically modified; for example, with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells. In one embodiment, the factor is hedgehog. In another embodiment, the factor is a DP cell protein. In another embodiment, the factor is wingless/int (wnt). In another embodiment, the factor is a Noggin protein. In another embodiment, the factor is a bone morphogenic protein (BMP). In another embodiment, the factor is a fibroblast growth factor (FGF). In another embodiment, the factor is a transforming growth factor beta (TGF-beta) protein. In another embodiment, the factor is sonic hedgehog protein. In another embodiment, the factor is a neurotropin. In another embodiment, the factor is any other factor known in the art that can contribute to induction of an epidermal cell to differentiate into an HF cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that represses one of the proteins or pathways shown in the present invention to be down-regulated in HF stem cells. In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells upon their activation.

In another embodiment, the inductive cell is an autologous cell. In another embodiment, the inductive cell is an allogenic cell.

In another embodiment, the inductive cell is derived from a mesenchymal stem cell. In another embodiment, the inductive cell is derived from a mesodermal progenitor cell. In another embodiment, the inductive cell is derived from a hematopoietic stem cell. In another embodiment, the inductive cell is derived from an embryonic stem cell. In another embodiment, the inductive cell is derived from an embryonic carcinoma cell. In another embodiment, the inductive cell is one of the cell types disclosed in United States Patent Application No. 2003/0201815. In another embodiment, the inductive cell is any other type of cell known in the art with inductive properties for an epidermal cell. Each type of inductive cell represents a separate embodiment of the present invention.

In another embodiment, the epidermal cell (e.g. the epidermal cell that is induced to differentiate into an HF cell) is an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF stem cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an anti-androgen compound. In one embodiment, the anti-androgen compound is finasteride. In another embodiment, the anti-androgen compound is Fluridil®. In another embodiment, the anti-androgen compound is dutasteride. In another embodiment, the anti-androgen compound is spironolactone. In another embodiment, the anti-androgen compound is cyproterone acetate. In another embodiment, the anti-androgen compound is bicalutamide. In another embodiment, the anti-androgen compound is flutamide. In another embodiment, the anti-androgen compound is nilutamide. In another embodiment, the anti-androgen compound is an inhibitor of an androgen receptor. In another embodiment, the anti-androgen compound is any other anti-androgen compound known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen compound. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen receptor agonist. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen analogue. In one embodiment, the estrogen analogue is estradiol. In another embodiment, the estrogen analogue is 17 beta-estradiol. In another embodiment, the estrogen analogue is 17 alpha-estradiol. In another embodiment, the estrogen analogue is ZYC3. In another embodiment, the estrogen compound, estrogen receptor agonist, or estrogen analogue is any other estrogen compound, estrogen receptor agonist, or estrogen analogue known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGF protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGFR. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a compound that reduces an expression of an EGF protein or an EGFR. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a nucleotide encoding a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an activator of a Hedgehog protein. Each possibility represents a separate embodiment of the present invention.

In one embodiment, a scalp is treated by a method of the present invention. In another embodiment, an eyebrow is treated. In another embodiment, any other hair-bearing area or region of the skin is treated. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a lithium compound. In one embodiment, the lithium compound contains a lithium ion. In another embodiment, the lithium compound contains a lithium atom.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with (2′Z,3′E)-6-bromoindirubin-3′-oxime (BIO). In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with any other compound known in the art that is capable of inducing an epidermal cell to differentiate into an HF stem cell. Each compound represents a separate embodiment of the present invention.

In one embodiment, the compound administered as part of methods of the present invention is administered systemically. In another embodiment, the compound is administered topically. In another embodiment, the compound is administered to the site of the abrasion. In another embodiment, the compound is administered to the site of the wound induction. In another embodiment, the compound is administered to the site of the depilation. In another embodiment, the compound is administered during wound healing. In another embodiment, the compound is administered prior to HF neo-genesis. In another embodiment, the compound is administered during HF neo-genesis. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method of inducing formation of an HF stem cell, comprising performing a method of the present invention. In another embodiment, the present invention provides a method of inducing formation of a DP cell, comprising performing a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, homologues and variants of transcripts and proteins of the present invention are administered in methods of the present invention. In another embodiment, homologues and variants of transcripts and proteins of the present invention are targeted in methods of the present invention. Each possibility represents a separate embodiment of the present invention.

The terms “homology,” “homologous,” etc, when in reference to any protein or peptide, refer in one embodiment, to a percentage of amino acid residues in the candidate sequence that are identical with the residues of a corresponding native polypeptide, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent homology, and not considering any conservative substitutions as part of the sequence identity. Methods and computer programs for the alignment are well known in the art.

In another embodiment, the term “homology,” when in reference to any nucleic acid sequence similarly indicates a percentage of nucleotides in a candidate sequence that are identical with the nucleotides of a corresponding native nucleic acid sequence.

In another embodiment, “homology” refers to identity of greater than 70%. In another embodiment, “homology” refers to identity of greater than 75%. In another embodiment, “homology” refers to identity of greater than 80%. In another embodiment, “homology” refers to identity of greater than 82%. In another embodiment, “homology” refers to identity of greater than 85%. In another embodiment, “homology” refers to identity of greater than 87%. In another embodiment, “homology” refers to identity of greater than 90%. In another embodiment, “homology” refers to identity of greater than 92%. In another embodiment, “homology” refers to identity of greater than 95%. In another embodiment, “homology” refers to identity of greater than 97%. In another embodiment, “homology” refers to identity of greater than 98%. In another embodiment, “homology” refers to identity of greater than 99%. In another embodiment, “homology” refers to identity of 100%.

Protein and/or peptide homology for any amino acid sequence listed herein is determined, in one embodiment, by methods well described in the art, including immunoblot analysis, or via computer algorithm analysis of amino acid sequences, utilizing any of a number of software packages available, via established methods. Some of these packages may include the PASTA, BLAST, MPsrch or Scanps packages, and may employ the use of the Smith and Waterman algorithms, and/or global/local or BLOCKS alignments for analysis, for example. Each method of determining homology represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a kit, comprising a tools and/or a compound suitable for performing a method of the present invention.

In another embodiment, the present invention provides a device, comprising a tool suitable for epidermal disruption and a means of delivering a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell.

In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. Each disease, disorder, or symptom represents a separate embodiment of the present invention.

Pharmaceutical Compositions

In another embodiment, methods of the present invention comprise administering a pharmaceutical composition comprising the HF stem cell-inducing or -activating compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof; and a pharmaceutically acceptable carrier. Each possibility represents a separate embodiment of the present invention.

The pharmaceutical compositions containing the HF stem cell-inducing or -activating compound can, in another embodiment, be administered to a subject by any method known to a person skilled in the art, such as topically, parenterally, paracancerally, transmucosally, transdermally, intramuscularly, intravenously, intradermally, subcutaneously, intraperitonealy, intraventricularly, intracranially, intravaginally or intratumorally. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the pharmaceutical compositions are administered orally, and are thus formulated in a form suitable for oral administration, i.e. as a solid or a liquid preparation. Suitable solid oral formulations include tablets, capsules, pills, granules, pellets and the like. Suitable liquid oral formulations include solutions, suspensions, dispersions, emulsions, oils and the like. In one embodiment of the present invention, the HF stem cell-inducing or -activating compounds are formulated in a capsule. In another embodiment, the compositions of the present invention comprise, in addition to the HF stem cell-inducing or -activating compound active compound and the inert carrier or diluent, a hard gelating capsule.

In another embodiment, the pharmaceutical compositions are administered topically to body surfaces and are thus formulated in a form suitable for topical administration. Suitable topical formulations include gels, ointments, creams, lotions, drops and the like. For topical administration, the HF stem cell-inducing or -activating compound or its physiologically tolerated derivatives such as salts, esters, N-oxides, and the like are prepared and applied as solutions, suspensions, or emulsions in a physiologically acceptable diluent with or without a pharmaceutical carrier.

In another embodiment, the pharmaceutical compositions are administered by subcutaneous implantation of a pellet. In another embodiment, the pellet provides for controlled release of HF stem cell-inducing or -activating compound agent over a period of time.

For liquid formulations, pharmaceutically acceptable carriers are, in another embodiment, aqueous or non-aqueous solutions, suspensions, emulsions or oils. Examples of non-aqueous solvents are propylene glycol, polyethylene glycol, and injectable organic esters such as ethyl oleate. Aqueous carriers include, in another embodiment, water, alcoholic/aqueous solutions, emulsions or suspensions, including saline and buffered media. Examples of oils are those of petroleum, animal, vegetable, or synthetic origin, for example, peanut oil, soybean oil, mineral oil, olive oil, sunflower oil, and fish-liver oil.

In one embodiment, the pharmaceutical compositions are controlled-release compositions, i.e. compositions in which the HF stem cell-inducing or -activating compound is released over a period of time after administration. Controlled- or sustained-release compositions include, in another embodiment, formulation in lipophilic depots (e.g. fatty acids, waxes, oils). In another embodiment, the composition is an immediate-release composition, i.e. a composition in which all the HF stem cell-inducing or -activating compound is released immediately after administration.

EXPERIMENTAL DETAILS SECTION
Example 1
Depilation and Epidermal Abrasion Causes De Novo Hair Follicle Formation
Materials and Experimental Methods

Depilation and Epidermal Abrasion

Mice were anesthetized with an injection of sodium pentobarbital before the hair on the back was clipped and depilated with Nair (Carter-Wallace, New York, N.Y.), then epidermis was removed using a rotating felt wheel as described by Argyris T, J Invest Dermatol, 75: 360-362, 1980). After scrubbing with 70% ethanol and drying under an incandescent lamp, the basal and supra-basal layers in an area of (1.5 cm)²cm of the inter-follicular epidermis were removed by careful abrasion with a felt wheel mounted on a Dremel Moto-tool (Racine, Wis.). After abrasion, the skin was shiny and smooth, and there was no blood. One day later, the abraded area was covered by a fibrin crust, which fell off after 3-7 days, exposing the newly regenerated epidermis. A group of control mice was sacrificed immediately after abrasion to confirm microscopically the complete removal of the interfollicular epidermis.

Immunohistochemistry

Skin samples were fixed in PBS-buffered 10% formalin. Six-micron thick paraffin sections were cut and stained, where applicable, with antibodies.

BrdU Labeling

The protocol described by Bickenbach and colleagues (Bickenbach et al, Cell Tiss Kinet 19: 325-333, 1986; Bickenbach et al, Exp Cell Res 244, 184-195, 1998) was used. Mice were injected with 50 milligrams per kilogram (mg/kg) bodyweight 5-bromo-2′-deoxyuridine (BrdU) every 12 hours for a total of four injections.

Results

An area of the backs of 50-day old mice was subjected to depilation and removal of the epidermis using a rotating felt wheel. Fifteen days later, HF placodes, hair germs and other signs of follicle neogenesis were present (FIG. 1; arrow indicates a hair germ). Morphology of the follicles was similar to embryonic follicle development. To further characterize proliferation in the new follicles, the skin was labeled with BrdU 60 minutes before sacrifice. As depicted in FIG. 2, the proliferation pattern was similar to developing follicles in the embryo.

These findings demonstrate that (a) disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (50-day-old mice are in the second telogen stage of the hair cycle).

Example 2
Induction of a Large Excisional Wound, but not a Small Punch Wound, Causes De Novo Hair Follicle Formation
Materials and Experimental Methods

Punch Wound and Excisional Wound Induction

The backs of 21-day-old mice were depilated as described for Example 1 and sterilized with alcohol, followed by 1% iodine solution. Punch wounds, 4 mm in diameter, were induced using a dermal biopsy punch, down to, but not through, the muscle fascia. Excisional wounds were full thickness and 1 cm in diameter; skin and panniculus carnosus was excised using fine surgical scissors.

Results

To test whether wounding could induce HF formation, punch wounds or excisional wounds were induced in mice. Both types of wounds exhibited contraction and re-epithelialization following wound induction; however, unlike the mice receiving punch wounds, the mice receiving excisional wounds also exhibited scar formation within 10 days of wound induction (FIG. 3, left panel). No follicles were evident at this time point (FIG. 3, right panel). 12 days after wound induction, hair germs, with similar morphology to fetal hair germs, were observed in the wound site, following BrdU pulse labeling (FIG. 4). Several markers were used to verify that the observed structures were HF. The structures exhibited staining with anti-keratin 17 (K17), an HF marker (FIG. 5), and staining with anti-alkaline phosphatase at the 12 day time point verified that the structures had dermal papilli containing fibroblasts, as expected for HF (FIG. 6; HF at earlier and later stages are depicted in the left and right panels, respectively).

The HF generated by wound induction were further characterized by morphological comparison to embryonic HF, following BrdU staining; a clear correspondence in morphology was observed at various stages (FIG. 7). In addition, several markers of embryonic HF development, namely Lef1, wingless/int (Wnt) 10b, and sonic hedgehog (Shh), were also induced in the epidermal disruption-induced HF neogenesis (EDIHN) (FIG. 8). Additional BrdU staining (FIG. 9) and staining for HF markers S100A3 and S100A6 (FIG. 10; left panel: tissue section parallel to HF axis; right panel: cross-sectional view of follicle) provided further verification that the development of the EDIHN follicles closely paralleled embryonic HF development.

These findings provide further evidence that disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (21-day-old mice are in the first telogen stage of the hair cycle).

Example 3
EDIHN-Induced Hair Follicles Generate Hairs

At 25 and 45 days after wound induction, wound sites contained new hairs (FIG. 11, left and right panels, respectively). New hairs appeared to lack pigmentation, except when the wnt pathway was inhibited, using Dkk-1 (Dickkopf-1) during the first nine days after wounding (see Example 10).

These findings indicate that EDIHN-induced HF function normally; i.e. are capable of generating hairs.

Example 4
EDIHN Hair Follicles Retain the Ability to Enter into Cyclical Hair Growth
Materials and Experimental Methods

BrdU Labeling

50 mg/kg bodyweight BrdU (Sigma) was injected twice per day for 3 days beginning 20 days after wounding. BrdU was detected 40 days after wounding (17 day chase).

Whole Mounting and Immunofluorescence

HF whole mounts were obtained by incubating fresh skin with EDTA (20 mM in PBS) at 37° C. overnight, then separating the epidermis and dermis. Epidermis was then fixed in 10% formalin for 10 min, room temperature (RT). Dermis was fixed in acetone overnight, RT. After rinsing with PBS, whole mounts were stained with antibodies for immunohistochemistry (schematically depicted in FIG. 12) and were imaged using a Leica confocal microscope.

Results

To determine whether EDIHN-induced HF contain normal levels of HF stem cells, mouse skin was examined for the presence of label-retaining cells at 21 days after wound induction. Retention of BrdU during a long chase period is, under these conditions, one of the hallmarks of HF stem cells. Normal numbers and placement of label-retaining cells (in the bulge of the HF) were observed (FIG. 13). To verify that the label-retaining cells were HF stem cells, K15-eGFP mice were utilized. In these mice, eGFP (enhanced green fluorescent protein) is expressed from the K15 promoter; thus, expression of eGFP identifies HF stem cells. As depicted in FIG. 14A, eGFP-expressing cells were observed in in tissue sections (right side) of newly formed hair follicles 35 days following wound induction. eGFP-expressing cells were also seen in the epidermis whole mounts (bottom, far left panel) indicating the conversion of epidermal cells into cells with hair follicle stem cell characteristics. ([bottom, second from left] panel is same as [bottom, far left] panel but viewed under white light) This finding shows that the observed label-retaining cells exhibited HF stem cell properties.

To determine whether EDIHN-induced HF cycle normally, mounts were prepared from additional mice at 35, 38 and 45 days after wounding. As depicted in FIG. 14B, the EDIHN-induced HF entered the resting phase, telogen, and then re-entered a new anagen stage.

In summary, the findings of this Example show that EDIHN-induced HF contain HF stem cells, as do embryonically generated HF. The presence of the HF stem cells shows that EDIHN-induced HF retain the ability to enter into cyclical hair growth in the same manner as embryonically generated HF. The findings also show that wounding induces epidermal cells to assume a hair follicle stem cell state (expressing K15-eGFP). This model is shown schematically in FIG. 15. The findings of Examples 2, 3, and 4 show that EDIHN-induced HF are fully functional and thus able to restore hair growth to a subject in need.

Example 5
EDIHN-Induces New Hair Follicles in Mice at the Telogen Stage of the Hair Cycle

To determine whether EDIHN was induced new hair follicles in mice wounded at the telogen stage of the hair cycle, 21-day-old mice were subjected to EDIHN using a 1-cm excisional wound, as described in Example 2. Skin was then examined by whole-mount assay for indications of new HF. As depicted in FIG. 16, after 11 days, new HF were not evident by macroscopic examination (top panel), AP staining of the dermis (bottom left panel), or K17 staining of the epidermis (bottom right panel). After 14 days, as depicted in FIG. 17, dermal papilla cells were detected in the dermis (left panel) and HF stem cells in the epidermis (right panel), demonstrating that new follicles were being formed. After 17 days, the new follicles were more developed, as shown by examination of the dermis and epidermis (FIG. 18, left and right panels, respectively). This method induced formation of an average of 49 new follicles in the wound, a number that was consistent over three separate experiments, as depicted in Table 1.

TABLE 1

Results of three separate experiments

performed on 21-day-old mice.

Sample
Expt 1
Expt 2
Expt 3

1
24
70
55

2
29
52
25

3
27
85
53

4
102
25
80

5
53
27
23
Avg of expts
Std dev of expts

Average
47
51.8
47.2
48.67
2.71

Std dev
32.8
26.3
23.7

The findings of this Example demonstrate that EDIHN is capable of inducing formation of new HF in mice at the telogen stage of the hair cycle, despite that fact that these mice do not contain HF at the anagen stage during wounding.

Example 6

In Adult Mice, Induction of Anagen Increases the Efficiency of EDIHN

The experiment described in Example 5 was repeated with mice of different ages, and therefore at different stages of the hair cycle. To ensure that wound scarring occurred, larger wounds were in induced in the older mice. As depicted in Table 2, adult mice at telogen, such as 8-week-old mice, exhibited lower efficiencies of HF formation by EDIHN.

TABLE 2

Efficiency of HF formation by EDIHN in adult

mice at various stages of the hair cycle.

Wound
Days
Mice exhibiting

Age
size
after wound
EDIHN
Hair cycle

3 wk
1
cm
20
25/25
(100%)
Telogen

4 wk
1
cm
20
5/5
(100%)
Early anagen

5 wk
1
cm
20
1/2
(50%)
Anagen

8 wk
1.5
cm
30
16/35
(46%)
Telogen

14 wk
1.5
cm
30
1/2
(50%)
N/A*

20 wk
1.5
cm
30
2/2
(100%)
N/A*

*The second telogen lasts approximately 40 days in mice. Thus, 14-week-old and 20-week-old mice contained a mixture of telogen and anagen HF.

To determine whether experimental induction of anagen increased the efficiency of EDIHN, 8-week-old mice were depilated several days prior to wound induction. As depicted in FIG. 19, the wounds closed similarly whether or not they were preceded by depilation. As depicted in FIG. 20A-B, the depilated mice exhibited enhanced EDIHN relative to the non-depilated mice depicted in the previous Example by a factor of 11-fold.

The findings of this Example demonstrate that anagen induction enhances EDIHN. In addition, these findings show that EDIHN is capable of not only fowling new HF, but also of activating anagen in pre-existing HF in the telogen stage.

Example 7
EDIHN-Induces New Hair Follicles in Human Skin
Materials and Experimental Methods

Grafting

Discarded human adult scalp from the preauricular area obtained from plastic surgery was grafted onto immunodeficient (scid) mice. The graft was bandaged and allowed to heal, then was used in the wound healing study 3 months after grafting.

Results

To determine whether human skin responded to EDIHN as did mouse skin, human skin was grafted onto SCID (immuno-deficient) mice and subjected to depilation by plucking and wound induction three days later. Seven days following wound induction, formation of new HF was observed in the human skin (FIG. 21A; arrows indicate new HF) by hematoxylin and eosin staining of paraffin embedded tissue sections.

In additional experiments, adult human skin was grafted onto mice, abraded, and examined at 7 days post-abrasion. New HF were generated in the human skin, which mimicked normal hair follicle formation during fetal development, as evidenced by staining for S100A6 or S100A4 (FIG. 21B).

The results of this Example show that EDIHN can be used to generate hair growth in human skin as for mouse skin.

Example 8
Molecular Pathways Activated During HF Stem Cell Activation
Materials and Experimental Methods

Isolation and Activation of HF Stem Cells

K15-eGFP mice were depliated in order to induce formation of new HF. Activated hair follicle stem cells were isolated from K15-eGFP mice using fluorescence-activated cell sorting (FACS) two days after depilation and 5 μg (micrograms) total RNA from the cell population was isolated, reverse-transcribed and hybridized to an Affymetrix (Santa Clara, Calif.) array MG_U74v2 chip. Scanned chip images were analyzed using Affymetrix Microarray Suite 5.0 and GeneSpring software (Silicon Genetics) to detect fold-change differences between activated HF stem cells (HFSCs) and non-activated (telogen) HFSCs. Values were normalized before computing fold-changes and differences between non-activated “bs-line” and activated (“expt”) samples.

Results

To identify molecular pathways up-regulated during HF stem cell activation, activated HF stem cells were isolated, and the gene expression patterns of the cells were analyzed to detect up-regulated transcripts. The transcripts depicted in Table 3 were up-regulated at least 2-fold in the activated HF stem cells relative to the cells prior to activation. In some cases, the sequence in Table 3 is a genomic sequence that contains the sequence of the transcript. Data pertaining to the up-regulation of the transcripts and further information about them is provided in FIG. 22.

TABLE 3

RNA transcripts up-regulated during HF stem cell activation.

SEQ

ID

No:
Access. #
Sequence

1
AW047343
uuuuuuuuuuuuuuuuucuuaaaaauauaaauguauuugucugcaucaugacguucuucgggc

accuagcuggccagaccacuggccaugggacaaggaggaagucagguguaagucugagcaagga

acaggacucugcccuggcaggguggagguggccucacagugucccaugcugggccugguagcgu

gaaagcacagcacgguagugggacagcuccugccgcacagccaccaccuccugccgcaacagggc

guuuuccuucuccaggaaggcagcccgcacagauauccgguucuccuugagucuucuugcaucuc

2
AF053235
Sequence below.

caguuccucagcauggccaccugcagccgccaguucaccuccuccagcuccaugaagggcuccuguggcaucggugguggcu

cuagccgcauguccuccauccuggcuggaggauccugccgggcucccagcaccugcgggggcaugucaguuaccuccucucg

cuucuccucugggggagucugugggauuggagguggcuauggugggagcuucagcagcagcaguuuugguggaggacuug

guaguggauuugguggucgauuugauggauuugguggugguuuuggugcuggucuuggugguggucuuggcgguggua

uuggugaugggcuccuggugggcagugagaaagugaccaugcagaaccucaaugaccgccuggccaccuaccuggacaaggu

gcgugcccuggaagaggccaacagagaccuggaggugaagauccgggacugguaccagaggcagcggcccacugagaucaaa

gacuacagccccuacuucaagaccauugaggaccugaagagcaagaucauuauugccacccaggagaaugcacaguucacuu

ugcagauugacaaugccaggcuggcagcugaugacuucaggaccaaguacgagaaugagcuguucuugcggcaguccgugg

agggugacaucaauggccugcgcaaggugcuagaugagcugacccuguccagagcugaccuggaaaugcagauugaaaaccu

cagagaagagcuggccuuccugaagaagaaccaugaggaggagaugcuugccuugaggggucagacugguggggacgucaa

uguggagauggacgcagcccccgguguggaccucagccgcauucugaaugagaugagggaccaguaugagcagauggcaga

gaagaaccgcagagauguggaggccugguuccugagaaagacugaggagcugaacaaagagguggccucuaacagugaucua

auccagagcaaccgcagcgagguggcugagcuccgcaggguguuccagggccuggagauugaacugcagucccagcucagca

ugaaagcauccuuggagaacagccuagaagagaccaaaggcagauacuguaugcagcugucccagauccaggguuugaucag

caguguggaggagcagcuggcucagcuucgcugcgagauggagcagcagagccaggaguacaacaucuuguuggaugugaa

gacaaggcuggagcaggagaucgccaccuaccgccgucugcuggauggcgagaauauccacuccuccucacagcacuccucu

ggacaguccuauucuucucgagaagucuucuccucauccucccgccagccccgguccauccucaaggagcaagguucaacca

gcuucagccagagccaaagucagaguuccagggacuaauguuuugccuagagccuccucacccacaacugccucucaagcug

agggcuuggggcaggacccuguuuucuuugcgcauuccccaucugucuccccuacccucucauggugguaggcuaauaaag

cuuuuugguugaugcaaaaaaaaaaaaaaaaaa

3
M26005
gcgccaguccuccgauagacugagucgcccggguacccguguucucaauaaagccucuug

cuguuugcauccgaaucguggucucgcugguccuugagagggucuccucagauugauugac

uacccacgucgggggucuuucauuuggaggccccagcgagauuuggagaccccugcccaggg

accaccgaccccccgucgggagguaagcuggccagcggucguuucgugucugucucugucuu

cgugcguguuugugccggcauuuaauguuugcgccugcgucuguacuaguuagcuaacuag

aucuguaucuggcgguuccgcggaagaacugacgaguucguauucccggccgcagccccugg

gagacgucccagcggccucgggggcccguuuuguggcccauucuguaucaguaaccacccga

gucggacuuuuuggagcuccgccacuguacguggcuuuguugggggacgagagacagagac

acuucccgcccccgucugaauuuuugcuuucgguuuuacgccgaaaccgcgccgcgcgucug

auuuguuuguuguucuuuuguucuucguuaguuuucuucugucuuuaaguguuuuucgag

aucaugggacagaccguaacuaccccucugaguuuaaccuugcagcacuggggagaugucca

gcgcauugcauccaaccagucuguggaugucaagaagaggcgcuggauuaccuucuguuccg

cugaauggccaacuuucaaugugggauggccucaggaugguacuuucaauuuaaguauuau

cucucagguuaagucuagaguguuuuguccugguccccacggacacccggaucaggucccau

auaucgucaccugggaggcacuugccuaugaccccccuccgugggucaaaccguuugugucu

ccuaaacuuccucccucgccgacagcucccguccucccgcccgguccuucugcgcaaccuccg

ucccgaucugcccuuuacccugcccuuacccccucuauaaaguccaaaccuccuaagccccag

guucucccugauagcggcggaccccucauugaccuucucacagaggaccucccgccguacgg

agcacaaccuuccuccucugccagagagaacgauaaagaagaggcggccaccaccuccgaggu

uucccccccuucucccauggugucucgacugcggggaaggagagacccucccgcagcggacu

ccaucaucucccaggcauucccacuccgcauggggggagauggccagcuucaguacuggccg

uuuuccuccucugauuuaacccuuccuuuucugaagauccagguaaauugacggccuuga

4
AA681998
gacguagagccccuugcgcccgguuuccugaucccgcuuacuccucugcgcgccggcaggau

ggcccacaagcagaucuacuacucagacaaguacuucgaugagcacuacgaguaccggcaugu

cauguuacccagagaacucucuaaacaaguacccaaaacucaucugauguccgaagaggagug

gaggagacuugguguccaacagagucuaggauggguucauuacaugauucaugagccagaac

cgcauauucuucucuuuagacgaccucuuccaaaagaacaacaaaaaugaagugcagcuggga

ucaucuaaucuuuuucaaauuuaauguauauguguauauaagguaguauucagugaauacu

ugaaaaguguacaaaccuuucauccauaccugugcaugcgcuguauucuucacagcaacaga

gcucagucaaaugcaacugcaaguagg

5
AF057156
atuaaaaagccagcugcccaaugccugcacacagaauccacaccaacagagaaccugcucuucu

cugaguauuagguaagucucugcuugcaacugauuugaaauucuugcuuauuuuuuuacua

ugaaaaacuguucaaagccaacucuauuacagaguugauguggggugcugccuacaguuagu

gaacaguagcauuguuugcuuaaauuauagcacauuuugggucuaggaacuugagagguga

uucaguuggucacuguaguagacagccuuggaaucagagauuaaggcaaaaggaaaccucca

uucaaauauucauggaaguucacagcuggagacagguuaaggcuucaguccagauagcuuuc

agaauuauugcaguucuuacugauaggcauaucaauagcgaaauuuaauuuauuagaggaau

cuacuaaaguaaauuuuuaggccaauauagaacauaccauacuuguagucuggcagagaagg

ugacauaugaaauugaaaugcgauucauagacagugguagugaaagaaauaaugguggggan

gggcugugcangggaggcauggcucaaggacagcacuuagugguagcacacaccaugaacua

ugauggaaaagcauuugauaggcagagacagaaauguaggaaauguguagggauccaugaga

gcauaaacuaaaagggcaaaagcauaugagcauggacuaacaugcagccacucugcaaguuau

acuaugaucuauuucacaaggagguugguaugcugcugucuuugggugacaccgcuuuccc

agauguccugguguguagguucacaagccucucagaagccauacuuuauugcuuuuuaaga

cguauuauuaauauuuuggcuagcauaugguuuagugugagaguuuuauaugcauauguca

uuauacuuugcucauuuaugucuuggaacuucuucaacuagguagaaaacaugaccagggag

aaugagaguaaggaaagaacccacugagacagacaagagcaaaccauacuucugcuaaucaug

uuuaaaaguccagaaaugaucauaccauauuuuauuuucaaguguggaagucagcauggaga

ggggcucuuuuucucuaaaggggccugaaauuaaauugacuugauguugagguuaccuucu

cuuucaaugaaucacuaaauugucuuuucuguuucccaggacccaagugcuaucuaaccaug

aguucccaccagcagaagcagcccugcacuguaccuccucagcugcaccagcagcaggugaag

cagccuugccagccaccaccccaggaaccuugugcccccaaaaccaaggaucccugccacccu

guuccugagcccugcaaccccaaggggccagagcccugccaccccaaggcacccgagcccugc

caccccaaggcaccugagcccugcaaccccaaggugccagagcccugccagccuaaggugcca

gagcccugccagccuaaggugccagagcccugcaaccccaaggugccagagcccugccaaccu

aaggcaccagagccuugccaccccaaggcgccugagcccugccacccuguuguucccgagccc

ugccccucaacugucacuccaucaccauaccagcagaagacaaagcagaaguaauauugucca

gagccaugccugaagaccugaucaccagaugcugaggcugcugucuauccugcuuaugaguc

ccauugccuugugcuaccaaugcugugaccuucagucuuaaucccucucuccuugcaccacc

uaaaaaguugacucucauccucaucuucaagggcuccugagccucuuaacauugcccaaagu

cauauugaauggcuacacuuuucauggcucaggauucaucugaagggggugaggagugaga

caaguguauggucaauauuuuccccccauuaaaugccauuuaacucc

6
AI845584
uuuuuuuuuuuuuuuuuagccaaaauaguuauuuauuaauaauuuaagguuuuacauucu

uauaauaaauuccagcucaaaacuuuacaccacgaacaucauggagcaaguuaauucucccuu

ccucucaaccuguugcauccaccaaaugggcgcucauacucgcacacauacacacacuuccag

uuucguauuuuuuuuuaaaaggaaagaaaccaacccaaaguauugcauuugaggugacacuc

ccugaa

7
AA614971
aagaugcccuuuggauuggauuggauugaucauguuuaacucagcguauuuuauggaugaa

agcuaaauacagauauuuggcaucucuaagguggaaugagcccacuccacacacugauaaaau

ucaugcauaguuu

8
AV374591
aaccaaaugggaaugggguccccaacnuuncugugguaccagccggguuucucuugcauug

gaaacaaacaccuuuguaggcauuugcguauucgugaagagacuguuuuaugaaucaccucu

uagauuuaunuaauuaaccuaaguuguugaaguuucuguuucuccuuaagagaaauuacaa

aaauucaacauugaagcauaguuucuuguuuucuguugucaaauaguaauaaugugcugug

auguuuaugcuuauucauaaagauguuuuacuuuuuaguguaauguuaguucuuuuuaaca

uuauuuugcuuaaauuugauaaugcccgacaagaauauauuuugcuuugauuuauacacug

auucuuugugacaaauaugacccauuaaaaaugccuuuuaauagacuaacuuaccuuuugua

gcuagguacucauguucuuuuuuaaaagaugcccuuuggauuggauuggauugaucauguu

uaacucagcguauuuuauggaugaaagcuaaauacagauauuuggcaucucuaagguggaau

gagcccacuccacacacugauaaaauucaugcauaguuuuaaaugaacauuaauaaacucaug

uugucuu

9
U04443
gaauucaaggaggcuuuccagcuguuugaccgaacaggugauggcaagauccuguacagcca

guguggggaugugaugcgggcccugggccagaacccuaccaacgccgaggugcucaagguuc

uaggaacccccaagagugaugagaugaaugugaagguacuggacuuugagcacuuccugccc

augcugcagaccguggcgaagaacaaggcccagggaaccuacgaggauuauguugaaggccu

ucguguguuugacaaggaaggaaauggcaccgucaugggugcugaaauccgucauguccua

gucacacugggcgagaagaugacagaggaagaaguagagaugcuaguggcagggcaugagga

cagcaaugguugcaucaacuaugaagcauuugugaggcauauccugucggggugacgggccc

gauggggcggagcucguccggauggugcugaauggcugagacauucuguaucccgagucug

uucccugcccagugugauuucuguguggcuccagacgcuccccugucacagcaccuuguccc

auuugguuucuuuggaugauguuugccuucaccaaauaaaauuugcucucuuugccc

10
Y07836
caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucaggg

auggauuuugcccacauguaccaaguguacaaguccaggcggggaauaaaacggagcgaa

gacagcaaggaaacuuacaaacugccgcaccggcugauugagaaaaagagacgugaccgg

auuaacgagugcauugcccagcugaaggaucuccuacccgaacaucucaaacuuacuacu

uugggucacuuggaaaaagcagugguucuggagcuuacguugaagcacgugaaagcauuga

caaaucuaauugaucagcagcagcagaaaaucauugcccugcagagcgguuuacaagcuggu

gauuugucgggaagaaaucucgaggcagggcaagaaauguucugcucagguuuccagacuu

gugcccgugagguacuucaguaccuggcgaagcaugagaacacucgggaccugaaaucuucc

cagcucgucacucaucuccaucguguggucucggagcugcugcaggguggugcuuccagga

aaccauuggacucggcucccaaagccgucgacuugaaagagaagcccagcuuccuagccaagg

gaucagaaggcccagggaaaaacugugugccagucauccagcggacuuuugcucccucgggu

ggggagcagagcggcagugacacggacacagacaguggcuauggaggugaauuggagaaagg

ggacuugcgcagugaacagccguacuucaaaagcgaccauggacgcagguucgccgugggag

aacgugucagcacaauuaagcaagaauccgaagagccccccaccacaaagagccgaaugcagc

ucucagaagaggaaggccacuucgcgggcagugaucugauggguuccccauuucuugggcca

cacccacaucagccuccuuuuugccuucccuucuaucucaucccaccaucggccacugccuac

cugccuaugcuggagaaaugcugguaccccaccucugugccaguguuauacccaggccucaa

caccucagcugcagcccucuccagcuucaugaacccagacaagauaccgacucccuugcuucu

gccccagagacucccuucuccuuuggcacauucgucccuugacucuucggccuugcuccagg

cuuugaagcagaucccuccuuuaaacuuagaaaccaaagacuaaacucuggagggaucuccu

gcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccugagugcagaga

gaucagcccacccugcagacccacagagaagauucagagugugugugagagugagugagugu

gcgugcgugcgugcuuguauguauguuuguauauguaggacaauaaguuccuucugacaca

agggagacacgagaaggauagccugacaucagaugacagacuggaggacuguagcacaucuc

ugggcguuucccuacccagagaagagcc

11
M21285
Sequence below.

uugcaggcgagggcuuccacaacuaccaccacaccuuccccuucgacuacucugccagugaguaccgcuggcacaucaacuuc

accacguucuucaucgacugcauggcugcccugggccuggcuuacgaccggaagaaaguuucuaaggcuacugucuuagcca

ggauuaagagaacuggagacgggagucacaagaguagcugagcuuugggcuucugaguuccuguuucaaacguuuucuggc

agagauuuaauauucuguugauuaacuaacaacuggauauugcuaucgggguguuaaugaugcauuuaaccuauuccggua

caguauucuuauaaaaugagaaagcuuugaucacguuuugagguaauaaauauuuuauuuagcuaggauuaaccaugccac

aagacauuauauauuucuaagcacacaugauaaaugcauauacaauuuugcacaacagcuuuaauaauaacaauaaauuug

aacauucuauacagagaggaucaaagccaaggaacaugcuguuuugaugcuagggugagcauggugcucagucccuguuug

uuugcaugguguccagcuuuguuucuucucugucaucaccaccuucaggcaaauaguugaccaaccacuggccugugucug

uccacccuccaaagcccaggccaccuuucuguuuucugaaauacugauccuuccuccugaauacaucccuccuuguuccuag

cuucaagacugcugccucaaauagggauagagcaaguccccgcugcagguugugcuagaugggauggagaaauuaucuuca

uuugauacagagcaaguagauugucucgagagaaaaguuagcaugcgugguaugauuuguaaguaaagauggaagagagag

agagagagagagagagagagagagagagagagagagagguagccauaucuaacagccuacuuaccaaagaccccaggccucuc

ugcuuggcaugccuccuuucuguccauccucugaaccccagagauuagugagauuugaauaauuaaaucauuuucagagug

aaggggguuaaugcagggucugugcuaggggaggguuuuagcuuuugguaacugaagauuuuuucauggaaaaagucuuc

guguucaaugugccuagaacugauaacuaaacagcugacauuugucggggacagauauggugugaaacuaugaaaauauaa

gcaaaaucuucacuuggaacaugaaacuauuucacuuagaaaauaaucgaaggacccgagguguugccuggguugccaguuu

cuuucguggcugggcaggaacuagugagguugaggggcagugucuguaaguagcugcuaagaggugcauuuccagaugaa

gcccuuggggaacaucugccagggauccgcaugguguuggcuccauccauugcuuuaguuuccuccuuggauuguguagaa

acuuggcuucccaugguuuugaaccuuccaugccuucuuugcuuuguggccacccagccugccuagugcugccuaggaagc

ucuuacccaccugauuucuucugacauuucuuucuuuggccuuuuuuucuuucuccggacaugcagcuaguugccugagu

guaucaagagcacccaggacuugcugcuguccaggccuguuccucccccaguauccguggguguggaagagcuguguagcu

ucaggaagcagagccaggugccaccuuucuguggcuuccagauccucccuaccuccaacucaugugccucugucacagugau

uucaggaaagcuugguagacccucuagcaacaucucgguucagaaagucucucugguuugugaguuaacagcucagcuaag

ugcuguuuugucucagugaguuaaccacugaaugcgaggguugguuguugaucugucucggugugugucggaguagacag

cauaugcacuucucccugugcgcuuugcaagguaauguggcuuuggcugauccaugcaggcagguagugguacagugcugc

ugaaaggaagaaguuccccauuuuaucuguuaaaacaccagagacaugggcaagugcuaauggaccucacuucaggaagagg

gucugcuuccugaagccagugugugaugaaaagugacugagaccugauaucuaaggugagaccugauaccuaacacucugu

cacacaguccagggccaacagugcuauaggaaagucuagaagaaaacaucacaucaguauuuuagaaccaucaaccaucucuu

gucccuauagcccaauccagaggccugguuuuuagaacuggcuguguaaggugccaaacacucaguucacuuguagaaucag

agccuuuuuuccccccuauguuaauugaacacgcgcucugagcuguuuuguugaaguagaaaaucucauagaaaaaucacu

guagaucuacugaccuauagcccucuggaaaugccuuugagaugguuuuacuuuucuaggucauagaugccugauuauaaa

gaugaacaauaaaaucagcuuucuuucuuucucuucugaucuuauuccccagaucugauucaggccauguuccaaagcaagg

cuacauugagguccuggugucuuuaaguaaaggacaucuuucagauccucucaaagaaggauuuauaacaguuuccagaug

aauguacuaauagcuuugggugccuuaucucuuuccuaaucuguagugccugugagcucagucucacuccuucccuuagcc

cggagaccccuuagaucgagugggaaugaucaagaggcuggcuggagagucaucaguacauugguuugcagaaaucuuuua

caggcuacauuuuggaauuuuuuuuuuuuuaguaagugaucaaauuuggugggaaguaauucgaguguauucgauuguau

ugucguccucguuaucauugucaaacauguuauagacggcaguuggcacuggggcugcuaaucucuggguguagucucuga

aacuguagcuccagugagguggugugaaagguuagcaaagccaccaucugcuggugcuccagccaaggugccucuuagccac

ugaauugcuauguuauccuuucucuuguaacaaacccaccccagagauaaagccuuuaaucaacccaagaaacuccugggcu

aaguaucugacagucucacaucucaacagugugaauuaaguguccauagcaucagcucaggaggacacucugggagagugcu

gacaaaaaaggguuauuaauacugaccuacuacuucaagggcaguucugaggugauuagagcuuuuuuuaaaaaccaaguau

uuggggauccucagcagagguauucauacagacucccaaagaacuauauauguuccugagaccaucguuuagucuacauugc

ucuucccagagacugacagauaugaccagucaaagugcaagacuaccuacccacugccaugaaaaccauugcaggaaaccuuu

cccuuccugaaugagauuuuuuuuuucccuuuuuaugugggguaauuauuugugacccaaguguaauuuggaugauuucc

auuaauaucaacucuugaagccuacuuguacugauugagauuguauuuguuccuaauaaaaguggaucugguuguacuguc

12
V00756
accacuugcagacaaaugaauuccuucgaaauguauuugagguuggacccccugugaugcuu

gaugcugcaacacuuaaaaccaugaagauuucucguuuugaaaggcauuuauauaacucugc

agcuuucaaagcucgaacaaaagcucgaagcaaaugccgagauaagagagcagauguuggaga

auucuuguagaugucugaauuugauggcuguuuucuaaucucuuccuuuauuauuauuuu

ugcuacuucuaauguauauaagcuuuuagagacaguuuuuuaucuuggucaacuuaaauaa

uuuuugauguagggguggguuguauuuuaauuuaauguacaguguuacaaauuaaugagu

ucuuuauucucuguaaaaauaacugguaaccacaaauaaaguguuugugauguuuggucgu

13
Y14296
auguccgcggccgccuacauggacuucguggcugcccagugucugguuuccaucuccaaccg

cgccgccgugccggagcacgggggcgcuccggaagccgagcggcugcgacuaccugagcgcg

aggugaccaaggaacacggugacccgggggacaccuggaaggauuauugcacgcuggucacu

aucgccaagagcuuguuggaccucaacaaauaccgacccauccagacccccucggugugcagc

gacagucuggagagucccgaugaggauauaggauccgacagcgacgugaccaccgaaucugg

gucgaguccuucccacagcccggaggagagacaggauucuggcagcgcgcccagcccacucuc

ccuccuccacucuggaguggcuucgaaggggaaacacgccuccgaaaagaggcacaagugccc

cuacaguggcugugggaaagucuauggaaaauccucccaucuuaaagcccauuacagagugc

auacaggugaacggcccuuucccugcacguggccagacugccuuaaaaaguucucgcgcucg

gaugagcugacccgccacuaccggacccacacuggggaaaagcaguuccguugcccacugug

ugagaagagauucaugaggagugaccaucucaccaagcaugcccggcgucacaccguguucc

aucccagcaugaucaagagaucaaaaaaggcucuugccugccccuugugaggugcuccccau

ggcagccaggcagagauggguccccggaaggacagagcucccaggaaacagacugacacaugg

aaaucugccacagcagaggcgcgcuggccacaggaggucacugcuucuuuggccaauauucu

gauaucucccugcacuguuuccaaaaagcacaugguagcccuaaggucaaagucaacauuug

guccccuugcagaggcaacucugaaccgucucugacugaagauucagacuggugguguacau

acgucunacugggugaguugaccccuggccucccacagugcagaaccacucucuugaaucac

auuaacuuuugagauuuaaaaaaaacccaaacccaacccnncaaaacnccaganacaccgaaac

ucuggauccucgaugcuugcugacucucagaauugnuunuucuucucanuuaugcaagcna

gagcacaccuacuccagcaugauuugucaucuaaagacuugaaaacaaaacaacaacaacana

aaguuacuuauagucaauggauaagcagaguccgaauuuacacuaaucaagacagaccuucg

aggggucacgauaaguccggaacuuucaaaccuugcuucguaugaauuguacuaucugaaca

uaaacugcacuuuuauuuucuaauaccgagggugaauacgguaaauacaugcuuugagggu

agaanccgacggucuguuuggcaccacguuauaaucugcunnuuuuaacgaguaccaccuug

gagggcaggcaaauaaaugcuuuuggguauuuucuccuuuguuuuugacaaaugcugcgga

ugggggaucgggaucggaggggagugcuuuuaaagauaauaaaaaaugagguaaauaauuu

uaacuuaugaauuuguuugaauuc

14
X16490
gagauugaaacaauggaagaacuuuccauggcaaacaccauguuugcccucaaucuccuu

aagcagauagaaaaaucaaacucuacccagaacaucuuuaucucuccauggagcaucuca

ucaacauuggccauaguucuccucggugcuggggguaacacugaacagcagauggccaaa

gugcugcaguuuaaugaaauuggcaguuaugguaucaccacaagaaacccagagaacuuc

aguggcugugauuucgcacaacagauacagaaggaaaauuauccuagugcuauuuuacaggc

acaagcaggagauaaaauccauucagccuucuccucucucagcucaacaaucaacaca

ccacagggggauuauuuguuagaaagugcaaacaagcuguuuggagagaagucugcaagauu

caaagaagaauacauccaacucucuaagaaauauuacucaacagaaccagaagcagug

gacuuccuugaaugugcugaagaagcuagggaaaagauuaauucuugggucaagacucaaac

caaaggugaaaucccaaaccugcuacccgaagguucuguagaugaagacaccaagauggugc

uggugaaugcugucuacuucaaaggaaaguggaaaacuccauuugagaagaaacuuaauggg

cuuuauccuuuccgugugaacucgcaugagagcauaccuguccagaugauguuccuccaugc

aaagcugaacauuggauacauaaaggaccugaagacucagauccuagaacuuccgcauacugg

aaacaucagcaugcuccuguugcuucccgaugagauugaggacgcauccacuggcuuggaau

ugcuggaaagugaaauaaacuuugccaacuucaacaaguggaucagcaaagacacacuggau

gaagaugauguuguggucuacauucccaaguucaaacuggcacaaagcuacgaacucaaguc

cauucuucaaagcaugggcauggaggaugccuucaacaagggcaaggccaacuucucaggaa

ugucugagaggaaugaccuuuuucuuucugagguguuccaucaagccagcguggaugucac

cgaggagggcacuguggcagcuggugggacuggggcaguuaugacaggaagaacuggccau

gguggcccacaguuuguggccgaucaucccuuucuuuucuuuaucauggacaaaauuaccca

cacgauacuauuuguugguagauucuccucacccuaaaaggggaagaccuauuuccacauga

gguuuuguagcaugaacuauaagccucagaauugcaucuucaagugccaaaaguuuaaauac

uuucuuacacauuuuuauacuucugcuauacacuaaauauaaccuaaaagcaauuguauagc

agucuucagugcuuacaguauaacucuauuaaugauuuuguuuccuaaagucagaugaugu

cuauuuaguucauccuuauuacugcuuugucuuuauaacuuuaguuuuuacaguguuauu

uauuguuuauauaaugguuguuuuacaaauuguuguccucuguuuaaugaaacuguaacac

uacagaagcagaaaauuagauaauuuucuauuuaaagaaaaucagccauuuaauuuaauaau

gaaggaaaaauaugagucuuccauacuuucccaugauauucacccagaaaaaauguacuuaac

aaaagacauguuauaucucuaucauuauauaucauauguacguaucugcaacucaucuauaa

uuaggacuacaucauaaguaagcaugcuuacuuacacacugcuaucuguuguauaaaacuua

gcaauccuuauuuguuaguuaucuuucuaucacuguaacaaaauaccugagauaauaaaguu

caaagauuuauuuugaaaaaaaaaaaa

15
AW120868
uuuuuuuuuuuuuuunuaagaauuaacuuuuauuuuugcuuaguuuuauuaaaaaaauaa

auaugucauaaagcuuuuguuuccuuuagggagaaaaaaaaggaacaaguuccauaaaauca

aacaagcaaugguaacaugucuuaacuugaaaacaacuggggucacugguuuacaaguuaua

acugaaugaaugacugccacaguugcccauuuccuccugccaauggcagcaaacaacaggauc

aacuagggcaaaauaaauaauuguguggaagcccuga

16
C78850
aacuaaacuuccuuguaacuuuugagaacucagcucugguacuuuuucaugccuugcaaaau

ggcguuanugcagcuagcuugcuaanccuuaugguggggucuuucauuccccccucuuucu

ggaaacugnauaaaaucauuuauucacgugauucuauuucuucuggaucuauugauuugag

uuggugauacuguugggucanaaccagggccuguu

17
D67076
Sequence below.

gcagcuccgagcuaggugcuaucgcaaggccagagcgcacagcccggcggagagagcagauccuugcucagaucgagucaaa

ucgggccaaggcggaggacgaagaguccaggcuccuauucuggacuuguuccccagcuccgggggcgcuucuagguccugc

agcagccagcagugcggagccaccaacucggugcuggaaugaaaaaauucccgcgcgccagugcagaaucuuucuaagugac

ccggagcuucgggugcuagcucugcacgaacuuucccaucaaagugaucgugaauuuuaagcaucaggagcaggccagcgaa

gcucuacgcgucuaaacgucuauccagaccaagaguucucugcggugcagggugcggugccaugcagccaaaagucccuuuu

ggggucacgcaagcagaagcccugcuccgacaugggggacguccagcgggcagcgagaucucggggcucucuguccgcacac

augcuguugcugcuccucgcuuccauaacaaugcugcuaugugcgcggggcgcacacgggcgccccacggaggaagaugagg

agcugguccugcccucgcuggagcgcgccccgggccacgauuccaccaccacacgccuucgucuggacgccuuuggccagca

gcuacaucugaaguugcagccggacagcgguuucuuggcgccuggcuucacccugcagacuguggggcgcagucccggguc

cgaggcacaacaucuggaccccaccggggaccuggcucacugcuucuacucuggcacggugaacggugaucccggcucugcc

gcagcccucagccucugugaaggugugcguggugccuucuaccuacaaggagaggaguucuucauucagccagcgccugga

guggccaccgagcgccuggccccugccgugcccgaggaggagucauccgcacggccgcaguuccacauccugaggcgaaggc

ggcggggcaguggcggcgccaagugcggcgucauggacgacgagacccugccaaccagcgacucgcgacccgagagccagaa

cacccggaaccaguggccugugcgggaccccacgccucaggacgcgggaaagccaucaggaccaggaagcauaaggaagaagc

gauuuguguccagcccccguuauguggaaaccaugcucguagcugaccaguccauggccgacuuccacggcagcggucuaaa

gcauuaccuucuaacccuguucucgguggcagccagguuuuacaagcaucccagcauuaggaauucaauuagccugguggu

ggugaagaucuuggucauauacgaggagcagaagggaccagaaguuaccuccaaugcagcucucacccuucggaauuucugc

agcuggcagaaacaacacaacagccccagugaccgggauccagagcacuaugacacugcaauucuguucaccagacaggauuu

auguggcucccacacgugugacacucucggaauggcagauguuggaaccguaugugaccccagcaggagcugcucagucaua

gaagaugaugguuugcaagccgccuucaccacagcccaugaauugggccauguguuuaacaugccgcacgaugaugcuaagc

acugugccagcuugaauggugugaguggcgauucucaucugauggccucgaugcucuccagcuuagaccauagccagcccu

ggucaccuugcagugccuacauggucacguccuuccuagauaauggacacggggaauguuugauggacaagccccagaaucc

aaucaagcucccuucugaucuucccgguaccuuguacgaugccaaccgccagugucaguuuacauucggagaggaauccaag

cacugcccugaugcagccagcacauguacuacccuguggugcacuggcaccuccgguggcuuacuggugugccaaacaaaac

acuucccuugggcagauggcaccagcuguggagaagggaaguggugugucaguggcaagugcgugaacaagacagacauga

agcauuuugcuacuccuguucauggaagcuggggaccauggggaccguggggagacugcucaagaaccuguggugguggag

uucaauacacaaugagagaaugugacaacccagucccaaagaacggagggaaguacugugaaggcaaacgaguccgcuacagg

uccuguaacaucgaggacuguccagacaauaacggaaaaacguucagagaggagcagugcgaggcgcacaaugaguuuucca

aagcuuccuuugggaaugagcccacuguagaguggacacccaaguacgccggcgucucgccaaaggacaggugcaagcucac

cugugaagccaaaggcauuggcuacuuuuucgucuuacagcccaagguuguagauggcacucccuguaguccagacucuacc

ucugucugugugcaagggcagugugugaaagcuggcugugaucgcaucauagacuccaaaaagaaguuugauaaguguggc

guuuguggaggaaacgguuccacaugcaagaagaugucaggaauagucacuaguacaagaccuggguaucaugacauuguca

caauuccugcuggagccaccaacauugaagugaaacaucggaaucaaaggggguccagaaacaauggcagcuuucuggcuau

uagagccgcugaugguaccuauauucugaauggaaacuucacucuguccacacuagagcaagaccucaccuacaaagguacu

gucuuaagguacagugguuccucggcugcgcuggaaagaauccgcagcuuuaguccacucaaagaacccuuaaccauccagg

uucuuaugguaggccaugcucuccgacccaaaauuaaauucaccuacuuuaugaagaagaagacagagucauucaacgccau

ucccacauuuucugagugggugauugaagaguggggggagugcuccaagacaugcggcucagguuggcagagaagaguagu

gcagugcagagacauuaacggacacccugcuuccgaaugugcaaaggaagugaagccagccaguaccagaccuugugcagac

cuuccuugcccacacuggcaggugggggauuggucaccauguuccaaaacuugcgggaaggguuacaagaagagaaccuuga

aaugugugucccacgaugggggcguguuaucaaaugagagcugugauccuuugaagaagccaaagcauuacauugacuuuu

gcacacugacacagugcaguuaagaggcguuagaggacaagguagcguggggaggggcugauacacugagugcaagaguac

uggagggauccagugagucaaaccaguaagcagugagguguggcaaggagguguguguaggggauacauagcaaaggaggu

agaucaggacacuacccugccaguuacauucugauaagguaguuaaugaggcacaguagcaucugaaagaccauacagagca

cuaaggagccccaaagcacuauuaguaucucuuuucuuauaucuaucgcccaaauaauuuucagagucuggcagaagcccug

uugcacuguacuaacuagauacuucuuaucacaaagauugggaaaggcaaagcagaaagaugguaagacuggguuucaaaca

aggcuugguuucaaucacuggaggcaaggaggaggggacaaacaagaucauuauucgaagucgcugguugcugugguuuua

cggaagguugaugcaucauuccuaucaacagugaaaaguucagcuuguucaacgugacagaaaggcucaucuccgugaaaga

gcuccugauuucuucuuacaccaucucaguucuuaacuauaguucauguugagguagaaacaauucaucuauuuauaaaau

guacauuggaaaaaaaaagugaaguuuaugagguacacauaaaaacugaaggaaacaaugagcaacaugccuccugcuuugc

uuccuccugagguaaaccugccuggggauugagguuguuuaagauuauccauggcucacaagaggcagaaaauaauacau

guugugccagaguuagaaugggguauagagaucagggucccaugagauggggaacauggugaucacucaucucacauggga

ggcugcugcag

18
M61007
ccgcgggcccgcguucaugcaccgccugcuggccugggacgcagcaugccucccgccgcc

gcccgccgccuuuagacccauggaaguggccaacuucuacuacgagcccgacugccuggc

cuacggggccaaggcggcccgcgccgcgccgcgcgcccccgccgccgagccggccauugg

cgagcacgagcgcgccaucgacuucagccccuaccuggagccgcucgcgcccgccgcgga

cuucgccgcgcccgcgcccgcgcaccacgacuuccucuccgaccucuucgccgacgacua

cggcgccaagccgagcaagaagccggccgacuacgguuacgugagccucggccgcgcggg

cgccaaggccgcgccgcccgccugcuuuccgccgccgccucccgccgcgcucaaggcgga

gccgggcuucgaacccgcggacugcaagcgcgcggacgacgcgcccgccauggcggccgg

uuucccguucgcccugcgcgccuaccugggcuaccaggcgacgccgagcggcagcagcgg

cagccuguccacgucgucgucguccagcccgcccggcacgccgagccccgccgacgccaa

ggccgcgcccgccgccugcuucgcggggccgccggccgcgcccgccaaggccaaggccaa

gaagacgguggacaagcugagcgacgaguacaagaugcggcgcgagcgcaacaacaucgc

ggugcgcaagagccgcgacaaggccaagaugcgcaaccuggagacgcagcacaaggugcu

ggagcugacggcggagaacgagcggcugcagaagaagguggagcagcugucgcgagagcu

cagcacccugcggaacuuguucaagcagcugcccgagccgcugcuggccucggcgggcca

cugcuagcgcggcgcgguggcguggggggcgccgcggccaccgugcgcccugccccgcgc

gcuccggccccgcgcgcgcgcccggaccaccgugcgugcccugcgcgcaccugcaccugc

accgaggggacaccgcgggcacaccgcgggcacgcgcggcgcacgcaccugcacagcgca

ccggguuucgggacuugaugcaauccggaucaaacguggcugagcgcguguggacacggg

acuacgcaacacacguguaacugucuagccgggcccugaguaaucaccuuaaagauguuc

cugcgggguuguugauguuuuugguuuuguuuuuguuuuuuguuuuguuuuguuuuuuu

uuuuggucuuauuauuuuuuuuguauuauauaaaaaaguucuauuucuaugagaaaagagg

cguauguauauuuugagaaccuuuuccguuucgagcauuaaagugaagacauuuuaauaa

acuuuuuuggagaauguuuaaaagccaaaaaaaaaa

19
C85523
aaaauguagaaggcaagauuuaauaaggcagcaacaugaaagcacacagaccagagcucu

ggggucgaaauaaagcagcaacauggaagcacacagagcucuggggucgaaacucauaca

ccuuagcacaggguagaggagucucgacggucanccagaauuuuucacaggcuuauauag

uaaaacucaaagggggagaacugggcagggaaaguacaaguuuacaucacuagggaguuc

ugccaaaggacaanggguucunucagaggaaucuacguaacuaaggngucauguccuauc

aaggnaucuacguaacuaaggagucauguccuaucauuuggcaauguacccgnucuuuu

gagguuguuccggagggncuuauucucaaaauguuuuucagauuggaagggguggguunc

cgguaaaaaguucuguuuucaaagaggcnguaauuuucuauucuucauuccccauucucc

uguaaguauucnnaucuuagaauuucagaaguccauauucncuauguggggaauaacugg

cuuuaacccnaucuuuaaaauggggg

20
AW122030
uuuuuuuuuuuuuuuuuaugaaacaguuuuguucagcccaugacuuugugcaugacuguc

guccguucuagucaccugugcucuccaucuacugccuuuuaaagcugcgucaugagaagg

aucuacacguuccaccaugacucucguuucuugccacaaguagaagaaaugguugauucu

uugcuuuucgguuaggccguuaaacaaaacucagucacaccccugccuuccacccucaaa

cugugaucacguggcuguucuuguaguunaaccagggcaacacuauauauuccaggucua

uacauugcugaggucuuuuucugguuguucauguaucaguguuuucaaccucgugccg

21
U57524
Sequence below.

gcggccgcggcuccagaccccggccuugcgcacccuccccccaccuccagcccgcgccucccccccccccacgcauggcucacc

accccucggguuucccugucaucccucagguuccugcacuuggcaaucauccacgaagagaagccgcugaccauggaaguca

uuggucaggugaagggagaccuggccuuccucaacuuccagaacaaccugcagcaggugcgcugcuugcuugccccgcggu

gccccucuuugaccccuugguggagucagauguagcacggucgcccccaaagcguuucuaaauuaauagucacuuaguucu

uaucugccuuggcuuuuuugcauucaaaucagccaacgucuuagaaccagaagaaaaaucccuugguuuuagugaggucuu

uaugacccaccuagggccuccuguuugccugaucuccuaagagacaaaugggaggaucagauuccauagcgggaggugucu

gggguucaggaaacucaagacuauggguuugcuccauggcuuaucccuuucuguuuccucuuccauuuguagacuccacuc

cacuuggcugugaucaccaaccagccaggaauugcugaggcacuucugaaagcuggcugugauccugagcuccgagacuuuc

gaggaaauaccccucuacaucuugccugugagcagggcugccuggccaguguagcagucuugacgcagaccugcacacccca

gcaucuccacuccguccugcaggccaccaacuacaaugguaggucugccaguccauccaaggaugcagaggagggagagaga

uggggccacuugagucuuaaacuccgaacguauacaaaguucagacacugugaucuuuuuaaaaaguuuucuccucgaugcc

uauaugauauucacucagaacccagauucugaguucuucaaaacugaugauguuugugguuguccucaagacaauagacau

gaguugugugaggauugaaacacguaguacaguuuuugucuuccuccuccaggccacacgugucugcaccuagccucuacu

cacggcuaccuggccaucguggagcacuuggugacuuugggugcugaugucaacgcucaggugaguacaucucccuuccac

cuaaucucuguugggcuggcucugauggugagcagguuuccagaugcagccguaaacuaacgccugauugcuuuugguuuc

aggagcccugcaauggccggacagcccuccaccuugcgguggaccugcagaauccugaccugguuucgcucuuguugaaaug

uggggcugaugucaacaggguaaccuaccaaggcuacucccccuaccagcuuaccuggggccgcccaaguacccggauacag

cagcagcugggccagcugacccuggaaaaucuccagaugcuacccgagagcgaggaugaggagagcuaugacacggagucag

aauucacagaggaugaggugaguguuccuccccucagcacgcugacggcuguucuagggcugcuuuggaucagagggauuu

caguuguuuaacuucucagacucggcuugcaaagcaggaucccaagaauuugucucugguuuguuuuaagagcuuacccuu

uugguugaggaaugagggaauucuagaaauugaacccaggccuuagcacauggugauaagcacacguucaaccauuaagcuc

cacccccucaauagcuuagacuuuuuuuuuuuuuaaggaaagaauagguaagggaaacuccuacagccuggugcccuuguu

cuauuuggguuaaggagaaaaagagcccaagaauaggaguuauuucagcagcagcucuccccuuaucccaaugucuugguga

aguucuaggaauuuaauaugucuuuuuccccucucuuguuuuagcugcccuaugaugacuguguguuuggaggccagcgu

cugacauuauaaguggaaaguggcaaaaaagaauguggacuuguauauuuguacaaauagaguuuuauuuuucuaaaaaaa

aaaaaaaaaaaaaaaaaaaaaaaaaaaaguauacuuagcaccacaccacacagcgccuagacccaggcauuuuacuggggugau

ucggcuguugucuuugugaaauccgggg

22
U05809
cucucggucacugccggucgcuuccugagccgcugcuggcucugugucucuguccucagc

guucucuuccucguccucguccuaccacgccauggaagguuaccauaagccagaucagca

gaagcuccaggcccugaaggacacagccaaucgccugcgcaucagcuccauccaggccac

caccgcggcaggcucaggccaccccacaucaugcugcagcgcugccgagaucauggcugu

ccuguuuuuccauaccaugcgcuacaaggcccuggauccccgaaacccucacaaugaucg

cuuugugcucucuaagggccaugcagcucccauuuuauaugcagucugggcugaagcugg

cuuccugcccgaggccgagcugcugaaccugaggaagaucagcucugacuuggacgggca

uccugucccgaaacaagccuucaccgauguggccacuggcucccugggccagggccuggg

agcugcuugcgggauggcauacacaggcaaauacuuugacaaagccagcuaccgagucua

uugcaugcugggagacggggaggucuccgagggcuccgucugggaggccauggccuuugc

uggaauuuacaagcuggacaaccucguugccauuuuugacaucaaccgccugggccagag

cgacccagccccgcugcagcaccagguggacaucuaccagaagcgcugugaggccuuugg

cuggcacaccaucaucguggacggacacagcguggaggagcugugcaaggccuuugguca

ggccaagcaccaaccaacagccaucaucgccaagaccuucaagggccgagggaucacagg

gauugaagacaaggaggcguggcacgggaagccccuccccaaaaacauggccgagcagau

uauccaggagauuuacagccagguucagagcaaaaagaagauccuggccacgcccccuca

ggaggaugccccauccguggacauugcuaacauccgaaugccuacgccacccagcuacaa

agugggggacaagauagccacccggaaggccuauggacuggcccucgcuaagcugggcca

cgccagugaccguaucauugcccuggauggagacaccaagaauuccaccuucucggagcu

cuucaaaaaggagcacccagaccgguucauugagugcuacauugccgagcaaaacauggu

gagcauugccgugggcugugccacacgugaccggacagugcccuucugcaguacuuucgc

ggccuucuucacacgggccuucgaccagauucgcauggccgccaucucugagagcaacau

caaccucuguggcucccacugugguguguccauuggggaagacgggcccucucagauggc

ccucgaagaccuggccauguuccggucaguccccauguccaccgucuuuuacccaagcga

uggaguugcaacagagaaggcaguggaguuagcagccaacacaaagggcauuugcuucau

ccggaccagccgcccagagaaugccauuauuuauagcaacaaugaggauuuccaggucgg

ccaagccaaggugguccugaagagcaaggaugaccaagugacagugaucggggcuggugu

aacucugcaugaggccuuggcugcugcagagagucuaaagaaagauaagaucagcauccg

ggugcuggaucccuucacuaucaagccccuggacaggaaacucauccuagacucugcccg

agcaaccaaaggcaggauccucaccguggaggaccacuacuacgaagguggcauaggaga

ggcagugucugcugccguagugggugaaccuggagugacggucacucgccuggcugucag

ccaaguaccacgaaguggcaagccagcugagcuacugaagauguucgguauugacaagga

cgccauugugcaagcugugaaaggccuugucaccaagggcuagggagggcaugggaugcu

gggugggugaacuacacauuccagggagguucuggcagagguggcgaagguguacugagu

ggggagguaaauauauguuuug

23
AW212475
uuaacggugucauaaauaaguaauauaacuuuauuaaaaugaaaagacaauauucaaaau

aaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggagaucagug

cauuuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuuuaaauag

cucaaauaaugucauucagcaguuuaaacugaacagcuuguugggacaug

24
V00835
ugaguucucguaaacuccagagcagcgauaggccguaauaucggggaaagcacuauaggg

acaugauguuccacacgucacaugggucguccuauccgagccagucgugccaaaggggcg

gucccgcugugcacacuggcgcuccagggagcucugcacuccgcccgaaaagugcgcucg

gcucugccaggacgcggggcgcgugacuaugcgugggcuggagcaaccgccugcugggug

caaacccuuugcgcccggacucguccaacgacuauaaagagggcaggcuguccucuaagc

gucaccacgacuucaacguccugaguaccuucuccucacuuacuccguagcuccagcuuc

accagaucucggaauggaccccaacugcuccugcuccaccgguaagacucccgauccuug

gucuuuagaauaccaaguugggaccgcagagcggaauccccgaguuguagaggcuuggcg

ggaauaggcaccuuuaguuggcgauucauuccgguucuuucuagaauccgcucuugcaaa

agccuucauuaguuacgaguauugucgaacggguccuuuggcgggguuggggcuaggauu

uagacgcgcaaauguccgguuccugaucacccaguuaguggggacaucuggguugagucc

caggcauuacuaaacuuacugugaauugcuugaauuaagaaagaggugaaggaccuuuau

gucuugggacucaaagacauaaucccugacuuaaccugugaggagaaaaguggggcuagg

cucccugcagcuccgaggaggacuuagugaacugagccgggacucgugguguuggccacu

gcuguaaugcugccucccucaugcugucuucuuucuccucccaggcggcuccugcacuug

caccagcuccugcgccugcaagaacugcaagugcaccuccugcaagaagagugaguuggg

acaccuuggguggcggcuaaggcuaggggcggggaacuccuacaaaacuggcucugagaa

auguccuuugcuucccggaggccauuguauugucucggggacagaacuauacagagaacu

auuuaaaaaaaccgaggucuucucuguuggggacaggaagcagaggucuucagccaggcu

gccucuuccuccuucuucuaggcugcugcuccugcugucccgugggcugcuccaaaugug

cccagggcugugucugcaaaggcgccgcggacaagugcacgugcugugccugaugugacg

aacagcgcugccaccacguguaaauaguaucggaccaacccagcgucuuccuauacaguu

ccacccuguuuacuaaacccccguuuucuaccgaguacguuaauaauaaaagccuguuug

agucuaacucugguuucuuggugugguuuggcaauaagaaacuggggugacuugauaguc

uggggaucugguuuuggacccccucgugccuuuaccuccgcccucuggcccucacagagg

gguaaugucuuuggguaaagccaagcuauaucccauaagcuuccucauggaaaacagcug

25
AV374868
gcggcacgaugugucuucggguggcuuuuuuuuuuuuguuuugaauaauguuuacaauuu

cccucaaucacuuuuauagaaauccaccuccaggccccccccuuuccccacuuaggccuu

cgaggcugucugaagaugcuugagaaacucaaccaaaucccaguucaauucagacuuugc

acauauauuuauauuuauaaucagaaaagaaacauuucaguaauuuauaauaaaagagca

cuauuuuuuaacg

26
M21285
See above (same Accession Number).

27
U74683
acugccaucgagugguguuccaguugaacuugcucucucugccaucugcuccgcgggcgc

cgucagcaugggucccuggacccacuccuugcgcgccguccugcugcuggugcuuuuggg

agucugcaccgugcgcuccgacacuccugccaacugcaccuacccugaucugcugggcac

cuggguguuccaggugggcccuagaaguucccgaagcgacauuaacugcucggugaugga

agcaacagaagaaaagguagugguacaccuuaagaaguuggauacugccuacgacgagcu

gggcaauuccgggcauuuuacccucauuuacaaccaaggcuucgagauuguguugaauga

cuacaaaugguuugcguuuuucaaguaugaagucagaggccacacagcuaucaguuacug

ccaugagaccaugacuggguggguccaugaugugcugggccggaacugggcuugcuuugu

uggcaagaagguggaaagucacauugagaagguuaauaugaaugcagcacaucuuggagg

ucuccaggaaagauauucugaaagacucuacacucacaaccacaacuuugugaaggccau

caauaccguucagaagucuuggacugcaacugcauauaaggaauaugagaaaaugagccu

gcgagaucugauaaggagaaguggccacagccaaaggaucccaaggcccaaaccugcccc

gaugacugaugaaauacagcaacaaauuuuaaauuugccagaaucuugggacuggagaaa

cguccaaggcgucaauuauguuagcccuguucgaaaccaagaaucuuguggaagcugcua

cucauuugccucuauggguaugcuagaagcaagaauucguauauuaaccaacaauucuca

gacaccaauccugaguccucaggagguuguaucuugcagccccuaugcccaagguuguga

ugguggauucccauaccucauugcagggaaguaugcccaagauuuuggggugguggaaga

aagcugcuuucccuacacagccaaagauucuccaugcaaaccaagggagaauugccuccg

uuacuauucuucugacuacuacuaugugggugguuucuaugguggcugcaaugaagcccu

gaugaagcuugagcuggucaaacauggacccauggcaguugccuuugaaguccacgauga

cuuccuacacuaccacaguggaaucuaucaccacacugggcugagugacccuuucaaccc

cuucgagcugacaaaucaugcuguuuugcuugugggcuauggaagagauccaguuacugg

gauagaauacuggauuauaaagaacagcuggggcucuaacuggggggagaguggcuacuu

ccguauccgcagaggaacugaugaaugugcaauugagaguauagccguggcggccauacc

gauuccuaaauuauaggacauagcucccaguguuacauacgggucuuuaucacucacaga

gugauuuagucacaugcugaagacuuuuucagagcaauaucagaagcuuaccacuaagca

ucuuuaaagaauuuugucuuugaacuuaaaaccauccuugauuuuuuucuuuuaauaucu

uccccaucaacuacugaacuacuuuucuuuuuaaaguacuugguuaaguaauacuuuuau

gagcagugguucaguuguccaauauuuuuugcaggucaucuacaaugcaaccagauguuu

caguucuaaaaaucuauguaaaaguacaagcucguuuuuaaauuauguaagucacaugaa

aacauggcaaaaaaauuaguuaaauuuuuuacaaagaguuuuaaauaaauguuuauguaa

ucaguaccauagucuuucuauguguguuuacaagaauuuuugucaccuacuucuucccuu

agaagcauuuaugcuccauggacguacuucuuuauggagaaaaaaaaaa

28
X61800
gagcucgaucccuguuccgccuuugcuaugucugaaggcguccugcuuugcgcgugucgg

ggccaaauccagauuuucauuucgcuccaggcuuggacggcuaaguagguccaaaccgca

caaacaggaaggagggaaggcaaggagugcgggcagagggcgggucguucccagcagcac

cccagucccuccccgcuccgucuccgacccacuggggccggggcgggcgugcgcgucagc

uggggcuagaaaaggcggcgguccggcccggcgaggugacagccaacuuggacgccaggu

ccggccgacgccgccaugagcgccgcgcuuuucagccuggacagcccggugcgcggcaca

cccuggcccacagaacccgcggccuucuacgagccaggcaggguggacaagcccggccga

gggcccgagccaggggaacugggggagcugggcuccacgacuccugccauguacgacgac

gagagcgccaucgacuucagcgccuacauugacuccauggccgccgugcccacccuagag

cugugccacgacgaacucuucgccgaccucuucaacagcaaccacaaagcggccggcgcg

ggcggccuggagcugcugcagggcggcccuacgcgacccccggguguggggucugucgcu

agggggccgcucaagcgcgaacccgacuggggcgacggcgacgcgccgggcucccugcug

ccggcgcaaguggcggugugcgcgcagacaguggugagcuuggcggccgcggcucagccc

acuccacccacuucgccggagccuccucgaggcagcccggggccgagccucgcgcccggc

acaguccgagaaaagggcgcgggcaagagggguccggaccgcggcagcccggaguaccgg

cagcggcgcgagcgcaacaacaucgcugugcgcaagagccgcgacaaggccaagcgccgc

aaccaggagaugcagcagaagcugguggaguugucggccgagaacgagaagcugcaucag

cgcguggagcagcucacccgggaccuggcuggccuccggcaguucuucaaaaaacugccc

agcccgccuuuccugccgcccaccggcgccgacugccgguaacgcgcggcgugggccuuu

gagacucugaacgaccuauaccucagaccccgacagcggggagcagacgccgcccgaauc

gcuaguuucuuugggaccugcgagcgacaggaagcugcagcuugggcacuggacugcgag

agaagcuauauuaaucuuuccccuuaaauuauuuuuuauaaugguagcauuuucuacguc

uuauuaccauugcagcuaagguacauuuguagaaaagacauuuccgacagacuuuuguag

auaagaggaagagacugcgcaugcuuuuuauauucauuuuuacaguauuuguaagaauaa

gaauaagaauaaagaagcauuuaaaucgcaaaaaaaaa

29
U20735
Sequence below.

uugaggguggccaggccagcguaggaggccagcguaggauccugcugggagcggggaacugagggaagcgacgccgagaaa

gcaggcguaccacggagggagagaaaagcuccggaagcccagcagcgccuuuacgcacagcugccaacuggccgcugccgacc

gucuccagcucccgaggacgcgcgaccggacaccggguccugccacagccgaggacagcucgccgcucgccgcagcgagcccg

gggcggcccuucagggggaccuuucccagaucgcccaggccgcccggaugugcacgaaaauggaacagccuuucuaucacga

cgacucuuacgcagcggcgggauacggucggagcccuggcagccugucucuacacgacuacaaacuccugaaacccaccuug

gcgcucaaccuggcggaucccuaucggggucucaaggguccuggggcgcgggguccaggcccggagggcaguggggcaggc

agcuacuuuucgggucagggaucagacacaggcgcaucucugaagcuagccuccacggaacuggagcgcuugaucgucccca

acagcaacggcgugaucacgacgacgcccacgccuccgggacaguacuuuuacccccguggggguggcagcgguggagguac

agggggcggcgucaccgaggagcaggagggcuuugcggacgguuuugucaagcccuggacgaccugcacaagaugaaccac

gugacgccccccaacgugucccugggcgccagcggggguccccaggccggcccagggggcgucuaugcugguccggagccgc

cucccgucuacaccaaccucagcaguuacucuccagccucugcacccucuggaggcuccgggaccgccgugcggacugggag

cucauacccgacggccaccaucagcuaccucccacaugcaccacccuuugcgggcggccacccggcacagcuggguuugaguc

guggcgcuuccgccuuuaaagaggaaccgcagaccguaccggaggcacgcagccgcgacgccacgccgccugugucccccauc

aacauggaagaccaggagcgcaucaaaguggagcgaaagcggcugcggaacaggcuggcggccaccaagugccggaagcgga

agcuggagcgcaucgcgcgccuggaggacaaggugaagacacucaaggcugagaacgcggggcugucgagugcugccgguc

uccuaagggagcaaguggcgcagcucaagcagaaggucaugacccaugucagcaacggcugccaguugcugcuaggggucaa

gggacacgccuucugagagccucccuugccccauacggacacccccagccuugaaggcugggcgccugccccccacuggggu

gaggggggcaggcgaugggcacccgccaaaaggccuggggcgcagcucacacacuggacuccggcccgcccgccugcgccca

guccuuccaccucgagguuuacauggcccccuuccagcguauuuuguauguuuuuuuuuucugcaaagagacugaauucau

auugaauauaauauauuuguguauuuaacaggagggagaagggggcugucgcggcggagcuggccgccgcuugguacucag

cugcggggauacuagggagggaccuccgcccccugcccucccccucugcauaguacuguggagaagaaacacgacuucgugu

cuaaagucuauuuuaagauguguuuguguguguguguuugacuuuuuauugaaucuauuuaagua

30
U19118
Sequence below

gaauucggcacgagcagcgagacgccgcgcacggugcuuccccaguggagccaaucggcuaacccgcgcuccggcagagucc

uuggcgcucgcccgccggcgggacagaccacccgccucuggccgcucucuggacccuggccgccccgagcgaagacuggagc

aaaaugaugcuucaacauccaggccaggucucugccucagaagucagugcgaccgccauuguccccugccucucaccuccug

ggucacugguauuugaggauuuugcuaaccugacacccuuugucaaggaagagcugagauucgccauccagaauaaacaccu

cugccaucggauguccucugcgcuggagucaguuaccgucaacaacagaccccuggagaugucagucaccaagucugaggcg

gccccugaagaagaugagaggaaaaggaggcggcgagaaagaaauaaaauugcugcugccaagugucgaaacaagaaaaagga

gaagacagagugccugcagaaagagucagagaaacuggagagugugaaugcugagcugaaggcccagauugaggagcugaag

aaugagaaacagcauuugauauacaugcucaaccugcaccggcccaccuguaucguccgggcucagaauggacggacaccgg

aagacgagaggaaccucuuuauccaacagauaaaagaaggaacauugcagagcuaagcagagguggcacggaggcaauuggg

gaguucuuacugaauccuccuuuuccaccccacacccugaagccauuggaaaacuggcuuccugugcacuucuagaauccca

gcagccaagagccguuggggcaggagggccuguggugaccuacugcauugacccacucugcccccgagugaaccguggagca

ggcaggagcauccuuugucucaccaauuccaggauuuaggccuuaucaucccggccagucucagaugaccuagcuggcccca

ggcugggguccuaugcaaagcaggaucccacuaaugggauucaggcagaagugucuaccuugauagguggggugggaccac

auccucuacuguggcugacaacgcccuuccaagggaauauggaaugagaacauucauuauugagguuguccaauggccaggg

uaugcuuucuagaaaauaugcuguucugucccagaaugacugugcauaggguauccguuucagagccugguguugugcuau

uuagauguuugucuugcacaacauuggcaugauuuuuccgggaguuucaucagaucugauuucugagagucuggggaucu

gccaugguggaaagugccccucaaaagcauuuguguggccacaugaacuggcuggcaccaggggagugaaacuggcugauga

ccagcugagccacuuugugccaacagaggauggacgacaccuuucccuguacccacugcagaggaagaacccugggcacagca

gcuuuguccuuggcuacaaacuguuacaacgucacacaaugaaggcacaaaguccaacuuucaaaggguguaggacuccaua

cucagugacagggcaggaagagccaaagauaaccacagccacagccuguggagaccaggguuggaagccaggugcagggcca

ggcaucugcauugugggauguuaauggcacuuuugucuuguagcuauuuugagaugugguccagagcauuucagcuggga

gaucucccucuggccaccaggacucuggcuacuguuaaaauccugauguuucuguggaauccucaguguuuaaucccacuca

auaguaucauuacaguuuucuguaagagaaaauauuacuuauuuaucccaguauuccuagccugucaacauaauaaauaucg

gaacaaaaccuggua

31
AW049031
uuuuuuuuuuuuuuuuugcugauaagaauucuuuuuauguuauucgaauaaaaaauaca

uucauacagaaauauaacaaucucgcaaaaaacaauuucaaauaaaaucuuguaaaacaaa

auuuuacaaaaaucuuacaaagauucuuuagauaacagggugcuucaaaaaaaaagaaau

aaagaaauuucacuaauagaaauuuuuuuuuuuaauuucaagcaaaaguuccugcuugau

ugaggcucaguugucaccugaccagaauggacugcuuaguauuaaaguuacagcaucgac

acggacggcacccagccccagccagaccagcaacgucgcuguguuucauaagugagacgc

gccagcacaaguuuccucucucuucuguuuaccuucuuacuuaauggaauugcuauggau

aagcacacagcagggccaaaaaaggaguuuuccaaaauccagcaaaucaagug

32
M93275
uaguggugaucuggaccgugcggacuugcucgucccucagcucuccuguuaggcgucucu

uuucuccaggaggaaaaaauggcagcagcaguaguggauccgcaacagagcguggugaug

agaguggccaaccugcccuuggugagcucuaccuacgaccuuguguccuccgcuuauguc

aguacaaaggaucaguacccguauuugagauccgugugugagauggccgagaagggcgug

aagaccgugaccucugcggccaugacaagugcccugcccaucauccagaagcuggagcca

caaauugcgguugccaauaccuaugccugcaaggggcuagacaggauggaggaaagacug

ccuauucugaaccagccaacguccgagauuguugccagugccagaggugccguaacuggg

gcgaaggauguggugacgacuaccauggcuggagccaaggauucuguagccagcacaguc

ucaggggugguggauaagaccaaaggagcagugacuggcagcguggaaaggaccaagucu

guggucaauggcagcaucaauacaguuuuggggauggugcaguucaugaacaguggagua

gauaaugccaucaccaagucggagaugcugguagaccaguacuucccucucacucaggag

gagcuggagauggaagcaaaaaagguggaaggauuugauaugguucagaagccgagcaac

uaugaacggcuggagucccugucuaccaagcucugcucucgggcuuaucaccaggcucuc

agcaggguuaaagaggccaaacaaaagagccaggagaccauuucucagcuccacuccacu

guccaccugauugaauucgccaggaagaauaugcacagugccaaccagaaaauucagggu

gcucaggauaagcucuaugucucguggguggaguggaagagaagcaucggcuacgacgac

accgaugagucccacuguguugagcacaucgagucacguacucuggcuaucgcccgcaac

cugacccagcagcuccagacuacaugccagacuguccuggucaacgcccaaggguuacca

cagaacauucaagaucaggccaaacacuugggggugauggcaggcgacaucuacuccgua

uuccgcaaugcugccuccuuuaaggaaguguccgauggcguccucacaucuagcaagggg

cagcugcagaaaaugaaggaauccuuagaugaaguuauggauuacuuuguuaacaacacg

ccucucaacuggcugguaggucccuuuuauccucagucuaccgaggugaacaaggccagc

cugaagguccagcagucugaggucaaagcucaguaaaccccuccuugucaccagagcaug

auguugcuggccagaugaccccuuuugcuguauugaaauuaacuugguagauggcuuuag

cuuagaaaagcagcuucuuagaaccaagggccucauuauggucacucacagcucaguuau

ggucuugccccagcuggcccuggcacaggaguucucuuaccuggcuggugaguggccugu

guuagucuugugaggaccuggaggaaccuaaaagcucagaugcacuuacagucuugucug

uggccuuuguauuguuauuggcuguaaacgucugucuggaccgaauaaagauucacguga

33
AB000713
ggcacgagggagcugcaguguucgcgcuugguagcuggugcaucggacucagcuggcuuu

gugucccugaggcucaccgaaaaacacuuucucagcccucugacuccagagagagagaga

gagagguacuuuuuguggucaccgacuuugaccccugcagaggcugagcgauggcgucua

ugggacuacagguccugggaaucuccuuggcaguccugggcuggcuggggaucauccuga

guugugcgcuccccauguggcgggugaccgccuucaucggcagcaacaucgucacggcac

agaccagcugggagggccucuggaugaacugcguggugcagagcacaggucagaugcagu

gcaagauguacgacucgaugcucgcccugccgcaggaccugcaggccgcccgagcccuua

uggucaucagcaucaucgugggugcucuggggaugcuucucucagugguagggggcaagu

gcaccaacugcauggaggacgagaccgucaaggccaagaucaugaucaccgccggagccg

uguucaucguggcaagcaugcugauuauggugcccguguccuggaccgcucacaacguca

uccgcgacuucuacaacccuaugguggcuuccgggcagaagagggaaaugggggccucgc

uuuacgucggcugggcggccuccgggcugcugcuccugggaggaggccuccucugcugca

guugcccaccucguagcaacgacaagcccuacucggccaaguacuccgccgcccgcucug

uccccgccagcaacuauguguaaggugggccacucuguccacauugccuuuguuauuuuu

uuucggauugagcucauaacagccuguggccccucacauucuccaggaccugcccugcua

ugggccacuaacugcuugcuggggacaggcaaacccggacugugcaaaguuacuagcccg

uagcucuugggcugcuccacauggcuccuuacggccggcaagaauggauguaaaaauauc

uugcugcuuacauccaaauugcgguggauaugggcugaaggcagaagcagcugggaaggg

caguagaggcgcaagcuggguccugcuggccgggguagcucagcugugacuuuggacucg

gaguggauguccucauguuagcaaacguccacuguccuuucucuaucccccucacucagc

cuacacguuacuccagcgcuacucuugccauuacgccccguguuuccgagcacagcuggu

ccuaccccaagucauggugugcugagugacugaugaggggccauugagagccggugggcu

cugccauggaacccuuccguugauuagcaaugacugugcuugacccacccaccuacccua

cuaaugaauuucuguagaguggauggacggguuugagggaagaaggguggagguggauu

aaacugguuuggggagggcuggggaccuagaagcagcccaguguguccccaccccuuuucc

gcacugucuugcuaauguucugaucacugugcgcccccucccucuucagaaggacccugg

gccucuugaguuggccccucugaguucccucccuuugcccauuucaaggacaccggccag

ucugcggaaggaagguacggggggggggggggggggugauggcauuguaccagggaguc

uccuggacuccccugccuucucugugguuucuuguuuuguaauuaaggucuguucacagc

uguaauuauuauuauuuucuacaauaaauggcaccugcauacag

34
U20735
See above (same Accession Number).

35
U83148
augcagcugagaaaaaugcagaccaucaaaaaggagcccgcaccccuagauccuaccagc

agcucagacaagaugcugcugcugaacucugccuuagcugagguggccgaggaccuagcc

ucaggugaagauuugcuccugaacgaagggagcauggggaaaaacaaauccucggcgugu

cggagaaaacgggaauucauuccggacgagaagaaagacgccauguauugggagaaacgg

cggaaaaacaacgaagcugccaaaagaucucgggagaagcgccgccucaaugaccugguu

uuggagaacaagcugauugcccugggagaagaaaaugccacuuuaaagcugagcugcuc

ucccugaaauuaguuugguuuaauuagcuccacggcguaugcccaagaaauccagaaa

cucaguaauuccacagcugucuacuuucaggacuaccagacauccaaggcugccgugagc

ucuuuuguggacgagcaugagccugcgaugguagccggaaguugcaucucagucaucaag

cacucuccccagagcucgcucuccgaugugucagagguguccucgguggagcacacucag

gaaagccccgcacagggaggcugccggagcccugagaacaaguucccugugaucaagcag

gagcccguggaguuggagagcuuugccagggaggccagggaggagcggggcacguauucc

accuccaucuaccagagcuacaugggaagcucuuucuccacuuacucccacuccccaccc

cucuugcagguccauggguccacuagcaacuccccaagaaccucagaggccgaugagggu

guagugggcaagucuucugauggggaagacgaacaacaggucccuaagggccccauccau

ucuccaguggagcugcaacggguucacgccacgguggugaagguuccggaagugaacccu

ucugccuuaccgcacaagcuucggauuaaagccaaggccaugcaggucaaaguggaggcu

uuggacagcgaguuugaaggcaugcagaaacucucuucacccgccgaugcgaucgccaaa

agacauuuugaccuggagaaacauggaaccucggguauggcccauuccucccucccuccu

uucucagugcaggugacgaacauucaagauuggucccucaaaucggaacacuggcaucac

aaagaacugagcagcaaaacucagaguagcuucaaaacaggugugguggaagucaaagac

gguggcuauaagguuuccgaagcugagaauuuguauuugaagcagggaauagcaaacuua

ucugcagagguggucucgcucaagagauucauagccacacaaccgaucucggcuucggac

uccagguaa

36
L10244
gcucccgggaaacgaaugaggaaccaccuccuccugcuguucaaguacaggggccuggug

cgcaaagggaagaaaagcaaaagacgaaaauggcuaaauuuaagauccguccagccacug

ccucugacugcagugacauccugcgacugaucaaggaacuggcuaaauaugaauacaugg

aagaucaagucauuuuaacugagaaagaucuccaagaggauggcuuuggagaacaccccu

ucuaccacugccugguugcagaagugccuaaagagcacuggaccccugaaggacauagca

uuguuggguucgccauguacuauuuuaccuaugacccauggauuggcaaguugcuguauc

uugaagacuucuucgugaugagugauuacagaggcuuugguauaggaucagaaauuuuga

agaaucuaagccagguugccaugaagugucgcugcagcaguaugcacuucuugguagcag

aauggaaugaaccaucuaucaacuucuacaaaagaagaggugcuucggaucuguccagug

aagagggauggaggcucuucaagauugacaaagaguacuugcuaaaaauggcagcagagg

agugaggcgugccgguguagacaaugacaaccuccauugugcuuuagaauaauucucagc

uucccuugcuuucuaucuuguguguagugaaauaauagagcgagcacccauuccaaagcu

uuauuaccagugacguuguugcauguuugaaauucggucuguuuaaaguggcagucaug

uaugugguuuggaggcagaauucuugaacaucuuuugaugaagaacaaggugguaugauc

uuacuauauaagaaaaacaaaacuucauucuugugagucauuuaaauguguacaauguaca

cacugguacuuagaguuucuguuuugauucuuuuuuuuuaaauaaacucgcucuuugau

uu

37
U88328
cgcuggcuccgugcgccauggucacccacagcaaguuucccgccgccgggaugagccgcc

cccuggacaccagccugcgccucaagaccuucagcuccaaaagcgaguaccagcuggugg

ugaacgccgugcgcaagcugcaggagagcggauucuacuggagcgccgugaccggcggcg

aggcgaaccugcugcucagcgccgagcccgcgggcaccuuucuuauccgcgacagcucgg

accagcgccacuucuucacguugagcgucaagacccagucggggaccaagaaccuacgca

uccagugugaggggggcagcuuuucgcugcagagugacccccgaagcacgcagccaguuc

cccgcuucgacuguguacucaagcuggugcaccacuacaugccgccuccagggacccccu

ccuuuucuuugccacccacggaacccucguccgaaguuccggagcagccaccugcccagg

cacuccccgggaguacccccaagagagcuuacuacaucuauucugggggcgagaagauuc

cgcugguacugagccgaccucucuccuccaacguggccacccuccagcaucuuugucgga

agacugucaacggccaccuggacuccuaugagaaagugacccagcugccuggacccauuc

gggaguuccuggaucaguaugaugcuccacuuuaaggagcaaaagggucagaggggggcc

ugggucggucggucgccucuccuccgaggcacauggcacaagcacaaaaauccagcccca

acggucgguagcucccagugagccaggggcagauuggcuucuuccucaggcccuccacuc

ccgcagaguagagcuggcaggaccuggaauucgucugaggggagggggagcugccaccug

cuuuccccccucccccagcuccagcuucuuucaaguggagccagccggccuggccuggug

ggacaauaccuuugacaagcggacucuccccuccccuuccuccacacccccucugcuucc

caagggagguggggacaccuccaaguguugaacuuagaacugcaaggggaaucuucaaac

uuucccgcuggaacuuguuugcgcuuugauuugguuugaucaagagcaggcaccuggggg

aaggauggaagagaaaagggugugugaaggguuuuuaugcuggccaaagaaauaaccacu

cccacugcccaaccuaggugaggagugguggcuccuggcucuggggagaguggcaagggg

ugaccugaagagagcuauacuggugccaggcuccucuccauggggcagcuaaugaaaccu

cgcagaucccuugcaccccagaacccuccccguugugaagaggcaguagcauuuagaagg

gagacagaugaggcuggugagcuggccgccuuuuccaacaccgaagggaggcagaucaac

agaugagccaucuuggagcccagguuuccccuggagcagauggaggguucugcuuugucu

cuccuauguggggcuaggagacucgccuuaaaugcccucugucccagggauggggauugg

cacacaaggagccaaacacagccaauaggcagagaguugagggauucacccagguggcua

caggccaggggaaguggcugcaggggagagacccagucacuccaggagacuccugaguua

acacugggaagacauuggccaguccuagucaucucucggucaguagguccgagagcuucc

aggcccugcacagcccuccuuucucaccuggggggaggcaggaggugauggagaagccuu

cccaugccgcucacaggggccucacgggaaugcagcagccaugcaauuaccuggaacugg

uccuguguuggggagaaacaaguuuucugaagucagguauggggcuggguggggcagcu

guguguugggguggcuuuuuucucucuguuuugaauaauguuuacaauuugccucaauc

acuuuuauaaaaauccaccuccagcccgccccucuccccacucaggccuucgaggcugucu

gaagaugcuugaaaaacucaaccaaaucccaguucaacucagacuuugcacauauauuuau

auuuauacucagaaaagaaacauuucaguaauuuauaauaaaagagcacuauuuuuuaau

gaaaaaaaaaaaaaaaaaaaaaaaaaa

38
X82786
Sequence below.

aaggaaucuucaguacagaaacaagacccaaguguaaguuuaacuggcaggaggaaccaaccaaggacaguuaaggag

aaaacccaacccuuagaagaacucaccaguuuccaagaggaaacugccaaaagaauaucuuccaaaucuccacaaccgg

aagagaaggaaaccuuagcagguuuaaagaggcagcucagaauacaacuaaucaacgaugguguaaaagaagagccca

cagcacagagaaagcaaccauccagggaaaccaggaacacacucaaagagccuguaggugacaguauaaauguugaag

agguuaagaagucuacaaagcagaaaauugauccaguagcaagugugccugucagcaagaggccacggaggguaccc

aaggaaaaggcacaggcccuagaauuggcuggucucaaaggaccaauccaaacccuaggccacacugaugaaucagca

agugauaaaggacccacacagaugcccuguaauucucuacaaccagagcaaguugacagcuuccaaagcucaccaagg

cgacccaggacaagacgugggaaaguagaggcagaugaagagccuucagcaguaagaaagacaguaucaacaucaagg

caaacuaugcgaucccgcaaggucccugaaauugguaacaaugguacccaaguuucaaaggccuccauaaagcagaca

uuagauacaguagccaaaguaacuggcagcaggaggcagcuaaggacacauaaaggaugggguucaacccucuugaa

guuguuaggugacuccaaagaaauaacccaaauaucagaucacucugagaaacuagcacaugacaccaguauccuuaa

gagcacucaacagcaaaagccagacucaguaaaaccucugagaacaugcagaagagugcugagggccucuaaagaggu

ccccaaggaaguguugguggacaccagagaccaugcaacauuacaaagcaaaagcaacccuuugcuguccccgaagag

gaagucugcaagagauggaagcauugugagaaccagggcuuugcgcucuuuagcaccaaagcaggaagcaacagaug

agaagccuguaccugagaaaaaaagggcugcuuccagcaagagguauguaucaccugagccugugaagaugaaacacc

ugaaaaucgugucaaacaaacuugaaucuguggaagagcagguuagcacuguuaugaaaacagaagaaauggaagcc

aaaagagaaaauccugucacuccagaucagaacucuagguaccgaaagaaaaccaauguaaaacagccaaggcccaagu

uugaugcaucugcagagaaugucgggauaaagaaaaacgagaagacuaugaagacugccucccaggagacagagcug

cagaauccagaugauggagccaagaaaucuacaucucggggccaagucagugggaaaagaacaugcuugaggucuag

aggaacgacugagaugccccagccuugugaagcagaagagaaaacaagcaaaccagcugcagaaaucuugauaaagcc

ucaggaagagaaaggagucucuggagagucugauguuagguguuugagguccagaaaaacuagagucgcuuuggac

agugaaccuaagccaaggguaacucguggaaccaagaaagaugcaaaaacucugaaggaggaugaagacauuguaugc

accaagaaguuaagaacaagaaguuaagaacaagaaguuaccagaaaagugaaacuauguagcaaagacauuuaagaa

ggaaaaguaaauuugacuuagugauaaguuccagugugguuuucaccuccaguguaaagaugaacuguaaauacuac

ugcuacugccugaguuuaaggaaggaagcuuugagcuuuccuggucauacucucuucagacgccaauggaggucau

gaggaagaucaccagggaucucagcgcaauuacaguuuaggggugagcaggcagaaauguggcccucuguccuaucc

aauaaagcucugaaauucgcugccaaaa

39
AW122523
uuuuuuuuuuuuuuuuuaaaucaaaaguuaugaugacuuuauuuuaaaucuuaauacacc

aaaaauauuuuucaauguugugagauaagcacuugaaaauaagaauuccaacacugcugu

gauuucgcugugaggcuugauagugaauuuucccucugaauauggguuuagggccuagga

agcagaaugccagucauuuuccaaguagcagugagcuaagcccagcccggucaugcucag

acccacacuuaacugaaauauucacacuaggaggcggcaccaccaggcaacaccuugauc

aaccaggagaacaaaagucugaagugccaccaagcauuggggaaaugauauuguuuagau

gcuagugagucagguucuuucaaauguguccuaacuggguugcaaacauaguugcauccu

uau

40
AI642048
gucuguaaaaaucuguuuaauaaauauacaucuuagaaguaccaaaauaauuaccaacaa

aauacaacauauacaacauuuacaagaaggcgacacagaccuuaguugggggcgacuuuu

aagcacaugccacugaacaccuggcucuuacaugggaggacacacugggcucacuuacua

ggucuauggugguucaaucaaaagcacaauaaauaaaacgugguccuuucauuagguucu

ggaaaaucaccucccccccccccaaaaaaaaucccacaaacaugaaccuuaagagacauu

uucuuugaauuucagugaucuguuuccccggauuucacaaagacaacagccgaaucaccc

caguaaaaugccugggucuaggcgcugugugguguggugcuaaguauacccuuucucauu

uuuuuucuuuuucu

41
L07264
cggccgccagaccuucaagggcuggaguggacgcgcggaccgacucugaacagacagacg

aaccgcggccgcaagguucccagacaggaucucacccagaggcaggcagcggacagugcc

uuaguggaaccucgcuguccuccaccgccuggccccggugcaggcguccaguggccgccg

cauccaaagugaucgcugccuccccgucuccgccagcucgggaccaugaagcugcugccg

ucggugaugcugaagcucuuucuggccgcaguguuguccgcguuggugaccggugagagu

cuggagcggcuucggagaggucuggcggcagcaaccagcaacccugacccucccacugga

uccacaaaccagcugcuacccacgggaggugaucgugcucaggggguccaggacuuggaa

gggacagaucugaaccuuuucaaaguugcuuucuccuccaagccacaaggccuggccacc

ccaagcaaagaaaggaaugggaaaaagaagaagaaaggaaagggguuagggaagaagaga

gacccaugccucaggaaauacaaggacuacugcauccacggggagugcagauaccugcag

gaguuccguacucccucuugcaaaugccucccugguuaccacggacacaggugucauggg

cugacucuaccaguggagaauccccuauacacauaugaccacacuacagucuuggcugug

guggcuguaguacugucguccgucugucuucuugucaucgugggacuucucauguuuag

guaccacaggagaggagguuaugacuuggaaagugaagagaaagugaaguugggcguggc

uagcucccacugaggaggaccugagcuauaggaaccuucagaggcuacuucugagacagug

guucguuacacguucuacauagaggagaaauauuucaccagcagccaugaaaacgucuuc

auucauuuccaguugcuacccugacugggccuccuguaau

42
M15668
ucgaccucacggucuugccaaaaugucgcuuuccaacaagcugacuuuggacaagcugga

cgugaaggggaagcgggucgugaugaggguggacuucaacguuccuaugaagaacaacca

gauaacaaacaaccaaaggaucaaggcugcuguuccaagcaucaaauucugcuuggacaa

uggagccaacuccguuguccuuaugagccaccugggccggccugaugguguucccaugcc

ugacaaguacuccuuagagccaguugcugcugaacucaaaucucugcugggcaaggaugu

ucuguucuugaaggauugugugggcccagaagucgagaaugccugugccaacccagcggc

ugggacugucauccugcuggaaaaccuccgcuuucauguagaggaagaagggaagggaaa

agaugcuucugggaacaagguuaaagcugagccggccaaaauugaugcuuuccgagccuc

acuguccaaacuaggagaugucuaugucaaugaugcuuuugggacugcacaccgagccca

uagcuccauggugggugugaaucugccacagaaggcugguggauuuuugaugaagaagga

gcugaacuacuuugccaaggcuuuggagaguccugagcgacccuuccuggcuaucuuggg

aggcgcuaaaguugcagacaagauccagcugaucaauaauaugcuagacaaagucaauga

gaugaucauuggugguggaauggccuuuaccuuccuuaagguccucaacaacauggagau

uggcacaucucuguaugaugaagaaggagccaagauugucaaagaucucauguccaaagc

ugagaaaaauggugugaagauuaccuugccuguugacuuugucacugcugacaaauuuga

ugagaaugccaagacuggccaagcuacuguggccucugguauaccugcuggcuggauggg

cuuggacugugguacugagagcagcaagaaauaugccgaggcugugggucgagcuaagca

gauuguuuggaaugguccuguugggguauuugaaugggaagccuuugccaggggaaccaa

gucacucauggaugagguggugaaagccacuucuagggguugcaucacuaucauaggugg

uggagacacugccacuugcugugccaaauggaacacagaggauaaagucagccaugugag

cacugggggcggugccagucuagagcuccuggaagguaaaguccuuccugggguggaugc

ucucagcaauguuuaguauuuucuuuccugccuuugguuccugugcuccuaagcuaaccu

gcuguuuuccacaucuccauuugguguuagcgcaagauucagcuaguggcugagaugugg

cacagaccuuaacagugcaagcaucucagcucgucuuacugcaucagaugcugguucuuc

aagaucccauuuaaauuccuuagugacuaaaaccauugugcauuguagagggcgucuauu

uauauucugccugagaaaggaagugagcuguaaaggcugagcucucucucugacguaugu

agccucugguuagcuucgucacucacuguucuugacucagcauggcaaucugaugaaauu

cccagcuguaagucugcagaaauuuccgaauuc

43
AI047508
uuuuuuuuuuuuuuuucauguuuaauaguuuauuucuuauuuuguugcuuauaucuuc

aauaaaucauuuugcagguuuuguuacagauuuuugauaagccaacucaaguacugauuu

uucauccucucugaaaguuuuaaaccaggaaaggaaaacguuccauggaauccaucuucca

cauggugaugagucacaugaacuccaacauucugaagccgcuugacauacaugaguccauc

aucucuuaggacaucauacuggcaagugaugauauaggucuuagguaaaugaugcaauau

auugucauuggccaacagagggcaugccuucacaucuaugaacccuggauacuuuugagc

cagcucagaacuaccaggagugggauuuuuguaaacgggacuuuucuuguaucucucagg

gagcaaggaacuccaauucacaaacuguaacaaguggcuagauuccauggguacauguug

guuga

44
AJ001418
Sequence below.

gagcacccgggacccugggaccacaacgcacuugcucccucucgaccgcgcuccugacccgcagcccucgccaacccuacgga

uccuaaccaccgccagccuaggugggcgucaggaugaaggcagcccgcuucgugaugcgcagcgccagcucgcugagcagcg

ccagccugguccccagggaggucgagcuguucucccgcuacagcccguccccgcuguccaugaagcagcugcuggacuuugg

uucagaaaaugccugugaaagaacguccuuugcuuuucugcggcaagagcugcccguccgccuggccaauauccugaaggag

auugacauccugccugaccgcuuagugaacacuccuucggugcagcuggugaagagcugguauauccagagccugauggau

uugguggaguuccaugagaagagcccagaagaccagaaagcccugucagaguuuguagacacgcuggucaaaguucgaaaca

gacaucauaauguggucccuacaauggcucaaggcauccuggaguauaaagacaccugcacaguggaccccguuaccaaucaa

aaucuucaguauuuuuuagaccgguuuuacaugaaccgcauuucuacucggaugcucaugaaucagcacauccucauauuca

gugacucaaagacgggaaacccaagccacauuggaaguaucgacccaaacugugaugugguagcaguaguccaagaugccuu

ugagugugcaaagaugcucugcgaccaguauuaucuaacaucgccagaauuaaaccucacacaagucaauggaaaauuucca

ggccaaccaauccacauuguguacguuccuucacaccuucaccacaugcucuucgaacucuucaagaaugccaugagggccac

ggucgagcaucaagaaaaccguccuuccuugaccccaguagaggccacugucgucuugggaaaagaagaccuuacaaucaag

auuucugaccgaggaggcgguguuccucugaggauuacugaccgccucuuuaguuacacguacuccacugcuccaacaccug

ugauggacaauucccggaaugccccuuuggcugguuuugguuauggcuugccaauuucucgucucuacgccaaguauuuuc

aaggagaucugaaucucuacucuaugucagguuaugggacagacgcuaucaucuacuuaaaggcuuuaucuucugagucug

uagaaaagcucccagucuuuaacaagucagccuucaaacauuaucagaugagcuccgaagcugaugacugguguaucccaag

cagggaaccgaagaaccuggcgaaggagaagcuggcagugugaagcggaugacgccugacauuuuacgggaucaaagugggu

cuguggcauugcugcuucgugaauguguguggacucuaguuuccgcaaaacaacgcaacacaaaaccaagcaagcaaaacaca

aacacgaguacaaaccuugaccugaugagggacagagcuugguuggaugacccgggagaagucagggcagggcuccagggga

uaacagguguccugcuucuccuuuggcaaugcaaaaugacuccugacuguuccaaauacugaaaagaagucugccucugagu

uacagcucuuucucaacaaguacagaguuugaggcuugcaguugcaacagcuggauguuuggugguucuugcugccagcca

aauaaauugguguuuagugaacauuuucaguguuuccccgccaugcaaagcuuggcgccuugggagaaauguguguaaaug

uacauuguauagguauuagugugcucuagaaaggacaggauggaaggaaucaaagcacuuuaucgagcuuguggcugagca

uugcagccuaugugcaaacccagaggaaaaguaucucugucaagacagcuccaguaucaugcagcuuuuuauguuugcacuc

aaaaagccagugccuucuggcuggugccgaggcuugggugaaauguuaaauaugcacugaccucagaaagucgaguucaaaa

gggagauaaaauugccaaagugauccaaggauugugcauguugggaaacccauaugagagaaaggauucucauacuuagaac

uuuccuaugaagaaauggugguaaacuuucucuaccuagaaguaguggaaauuucaaggucaucuuaaaaaagaugugcgu

uguauauuuuaacuacauucucuacacucuaacauuaacauaucuauucaaauuugucuaguugccaauugucuucagagu

gugaaaauuuaaauccuucuugaaguaucuuucgugagaguaguauggaaguaaaacguucucauaucaggaggaugucau

uugugaagcauggggacaucaugaacuagugaugugcgugaggcuugggaggcugaaggguaaggaucagcgggaggccau

ccauguaggagagagaauuaaaacgaggagcgagggaagcaauggagagagggaagcaagaaaggaaccagaaggcuggcau

cauccuauuucccacaggcuaacccaagggaugcucugugccuuuccuggggagggaagggggugaacugguagauuugaa

agcaguauggcuucuucugugggucucccucuuacuagacaaggugaaaugauaauucgugucaaauuaaugugaaauuuu

uuuccugcauuguaauauuaugaggccugagucgcaguugaguuugaaauuuguauuuaauuucacagugaccuagagcua

aggugcucccgguuguggcaauaggagccacaaguauuuucuuucuuucuuucguucuuucuuucuuucuuucuuucuuu

cuuucuuucuuucuuucuuuccuuccuuccuuccuuccuuccuuccuuccuuccuuccuuccuucuuccuuuccuuuucu

uuucucuucucuucuuuucuuuuuucuguuucuuuuucuuuuuuugcauuguagauguuguccuuaaaagaucagggca

gugacuuucacagcaggacuuugacucccacauugguugaucacacaaaacugucagcauuuggguaaucugauguauagu

uguuuuguugcugauguuuccauugaaauuucagcucugaguuugugcacaugaauacuuacuuguguuuaccaaagguc

uaaggcauuugguuacuuaacccaaauauccugaacugugcguaaaguaauagagaaaagcuuuagggucucaauaguguca

ccuguguaaaucaaaucaaaauagccuucccuauuauuuaugaacccaugggagacuuuaaacucuuguagauagaugcuaa

augcccaggcccacuuaacuuauuaaugugugaauuacauuuauguuuuuaguuuauaugcaaagaauugugauaauuuua

uaauaaauauuuuuauuauaauagu

45
AI838080
uuuucuuuuuuuuuuuucuucucuuuuuucugccaccaacagcacugugcaguuuauua

accauucauguacaguagccaucuggggagauugggacagaauugggaucgcaaagugga

uagauauucagcaucuaauggguuggcagaagccgccauauacucuucacaaauaucuucc

acagucaauacagaacuagccauuaucccagcacaccgauuugugc

46
AF072127
agccaggagccucgccccgcagcugcacagagagcaaggguauaggcacuaacuuguuug

cagagaccccaucaccuucgggagcucaggugcgcaccuugcaaacuccacuuucugcau

cugccacugagcccgcgggagccucggaaagagccauggccaacgcggggcugcagcugc

uggguuucauccuggcuucucugggauggaucggcuccaucgucagcacugcccugcccc

aguggaagauuuacuccuaugcuggggacaacaucgugaccgcucaggccaucuacgagg

gacuguggauguccugcguuucgcaaagcaccgggcagauacagugcaaagucuucgacu

ccuugcugaaucugaacaguacuuugcaggcaacccgagccuugaugguaauuggcaucc

ugcuggggcugaucgcaaucuuuguguccaccauuggcaugaagugcaugaggugccugg

aagaugaugaggugcagaagauguggauggcugucauugggggcauaauauuuuuaauuu

caggucuggcgacauuaguggccacagcaugguauggaaacagaauuguucaagaauucu

augaccccuugacccccaucaaugccagguaugaauuuggccaggcccucuuuacuggcu

gggccgcugccucccucugccuucugggagguguccuacuuuccugcuccuguccccgga

aaacaaccucuuacccaacaccacggccuuaucccaagccaacaccuucuagugggaaag

acuaugugugacagaggcaaaggaagagaucuuccuggagcaaauacaaaauggacauug

aaccuaggauugacauuaacgccuuagacuguugaugaugguuaucggaacugugguaga

acagaaggaagcauauuuuuauacauccccauggcuaugcaggccuuggcug

47
X80417
Sequence below.

cggcacgagcggccacugaccgagaagugcccccgccuggagucagccugggggcaggccaggguccaccagacccc

gggaugaccgcagccagucgggccaaccccuacagcaucguaucaucagaggaggacgggcugcaccugguuaccau

gucaggcgccaacgguuuuggcaauggcaaggugcauacacggcgccggugccgcaaccgcuucgucaagaagaacg

gucagugcaacauugaauucgccaacauggacgagaagucacaacgcuaccuggcugacauguuuaccacgugugug

gacauccgcuggcgcuacaugcugcucaucuucucucuggccuuucuugccuccugguuguuguuuggcaucaucu

ucugggucauugcugucgcccacggggaccuggagccagccgagggccguggccguacacccugugugcugcaggu

ccacggcuucauggcagccuuucucuucuccauugagacacagaccaccauuggcuacgggcuacgcugugugacug

aagagugcccgguggcugucuucauggugguggcgcaguccauugugggcugcaucauugacuccuucaugaaugg

ugccaucauggccaagauggcacggcccaagaagcgcgcacagacucugcuuuucagccauaaugccgugguggcuc

ugcgugacggcaagcucugccucauguggcgcgugggcaaccugcguaagagucacaucguggaggcccaugugcg

ggcccagcucaucaagcccagggucacagaggagggugaguacaucccacuggaccagauugacaucgaugucggcu

uugacaagggccuagaccguaucuuccugguaucacccaucaccaucuugcacgagauugaugaggccagcccacug

uuuggcauuagccgucaggaccuugagacagacgacuuugagauuguggucauccuggagggcaugguagaggcca

cagccaugaccacacaggcucgcaguuccuaccuggcuaacgagauccuguggggccaccgcuuugagccagugcuc

uucgaagagaagaaccaguacaagauugacuauucacacuuccacaagaccuacgaggugccaucuacaccccgcugc

agcgccaaggaccugguggagaacaaguuccuccugcccagcgccaacucuuucugcuaugagaacgagcuggccuu

ccugaucagagaugaggaggacgaggugucuaccgaccgggauguccgcaccccucagcccgagcaugacuuugaca

gacugcaggccagcagcgcugcccuugugcggcccuacagacgggagucggagauuugaaugcccuuggcuuagaug

cagcaccacccugaccacaauaggucccaugucccuugggggccugcguuugagcagagcaggccgaaagccucggg

ucacagacucaguagcaucuuagucuuuuucauguuuuuucgcaguagcuugggaaaguuggcgggagcguggaug

gcccaaaugacuggcucacggccucggaggcugauguauacccaugggcaaggaggugacuucuugggguaggguu

gcucaggaguuagggacucugcuggaggccuuaggugcaggucccaaccccggugggaggaggcuguguauguaca

cuucauugguuuuuaacuugggcaagacuguuuacaaaccaaaacaaacaaacaaacaauc

caaaaaaaaaaaaaaaaaaaaaaaaaaaa

48
AI847051
uuuuuuuuuuuuuuguuccuuuuuuggaauucccaaagcugguuuuaauuucaaaaaau

uaugaggucucuucccacacuggggauaaugggaugggauagcccaaacuauuaucccagu

ucaaccccagccugguccaaacaccauuacugucacugggcccugucauuucacc

49
U09504
uccucguccucgucuguuccaucuucuccaaauagcucuaacugugaugccaacggcaau

cccaagaacgcugauaucucuagcaucgaugguguucugaagagugaccgcacagauugu

ccugugaaaacaggcaaaaccagugcuccuggcaugacuaagagucacaguggaaugaca

aaauuuaguggcaugguucuacuguguaaagucuguggggauguggcaucaggauuccac

uauggaguucaugcuugugaaggcuguaaggguuucuuucggaggagcauucagcaaaac

auccaguauaagaagugccugaagaaugagaacuguuccaucaugaggaugaacaggaac

cggugccagcagugccgcuuuaagaagugucugucuguggggaugucacgagaugcuguu

cgauuuggccgaauuccuaagcgugaaaaacagagaaugcuaauugaaaugcaaagugca

augaagaccaugaugaacacccaguucaguggccaccugcagaaugacaccuuagcagaa

cagcaugaucagucagcacuaccagcucaggaacagcugcggcccaagucccagcuggag

caagaaaacaucaaaaacacuccuucugauuuugcaaaggaggaagugauugguauggug

accagagcccacaaggauaccuuucuguauaaucaggaacaucgagaaaacucaucugag

agcaugccaccucagagaggagaacggauucccaggaacauggagcaauauaauuuaaau

caagaccaucguggcagugggauucacaaccacuuccccuguagugagaggcagcaacau

cucaguggacaguacaaagggaggaacauaaugcauuacccaaacggccaugccguuugu

auugcaaauggacacuguaugaacuucuccagugcuuauacucaaagagucugugauaga

auuccaguagguggauguucucagacugagaacagaaauaguuaccugugcaacacugga

gggaggaugcaucugguguguccuaugagcaagucuccauauguggacccucagaagucu

ggacaugaaaucugggaagaauuuucaaugaguuuuaccccagcaguaaaagagguggug

gaauuugcaaagaggauuccuggcuuccgagaucugucucagcaugaucaggucaaucug

uuaaaagcugggacuuuugagguuuuaaugguacgauuugcuucauuauuugaugcaaag

gaacggaccgucaccuuucuaagugguaagaaguacaguguggaugaccugcacucaaug

ggagcaggggaucugcucagcucuauguuugaguucagugagaagcugaaugcccuccag

cucagugaugaggaaaugagcuuguucacagcaguuguucugguaucugcagaucgaucu

ggaauugaaaaugucaacucaguggaggcuuugcaggaaacacucauccgugcacuaagg

accuuaauaaugaaaaaccauccaaaugaggccuccauuuuuacaaaauuacuucuaaag

uugccagaucuucgaucuuuaaacaacaugcacucugaggaacucuuggccuuuaaaguu

cauccuuaa

50
U22033
auggcguuacuggaucugugcggugccgcucgggggcagcggcccgagugggcugcccug

gaugcgggaagcgggggucgcucggacccgggacacuacaguuucuccgcgcaagcuccg

gagcucgcacuuccccggggaaugcagcccaccgcauuccugagguccuuugguggugac

caggaaaggaauguucaaauugagauggcccacggcacaaccacacucgccuucaaguuc

cagcauggcgucaucguggcuguggacuccagggccacugcagggaguuacauuagcucc

uuaaggaugaacaaagugaucgagauuaacccuuaccugcuuggcaccaugucugguugu

gcagccgacugccaguacugggagaggcuguuggccaaggagugcagguuguauuaucuu

cggaauggggaacgcaucuccgugucugcagcauccaagcugcuuuccaacaugaugcug

caguaccgggggaugggccucuccaugggcagcaugaucuguggcugggacaagaaggga

ccaggacuuuacuacguagaugacaaugggacucggcucucgggacagauguuuuccacu

ggcagcgggaacaccuaugccuacggggugauggacagugguuaccggcaggaccucagu

ccugaagaggccuacgaccuuggccgcagagcuauugcuuaugcuacccacagagacaac

uauucuggaggagucgucaacauguaccacaugaaggaagacgguugggugaaaguggag

aguuccgaugucagugaccugcuguacaaguaccgagaggccgcucuguga

51
AF033034
Sequence below.

auuccaggaguuccagcugcuggagaggacuguguagaagguaaccuaccccaucucucuuacuucgucucuagaugggag

cagacaaguacauauagccugcuuggagcgaggacuuugaaaggcugagacuugcguccacucugagggcaacuaguccaga

cucugacaggucagcauuuccugacugggugcacugaaugccaagcaccagaggucugucaccuuccgacauuggaccaaga

gagucccagagacccucaaagacacaggaacagagguguccuuugggugagagaccugugcccugccaagccucucagcccc

uagaaaggcggcagggcugaguagcugagugugugcaacuugggagcagccugauuucagugcuugucaccugugagggca

aaggcagcaugcuuaaugccaucaguccuacucuucucacccguggaacagacgcauaacugaccuuuuuucgugaccacua

uuagggugcauuuaaaaaucaaucucucucuuuucugcuccucuuucuccaccuucccucaugugugugucugugugugu

guguuucugugugugugugcgugcaccauacagguauaugugccaugacaugugugcaggucaguagacagccuugguug

ucagucccugccuucuacuuuguucaaggcagggucuauucuuuauuauugacugcuauccagguacaccaagacaguugg

ccugugagguuccagggagucuccugucucuggcccccaucuuauagcaggaguugugagauuucagaaaugugcacccac

aucuagcuuuauuuggcaucuuggcacccaaacuuggguucucaugcuuuccaagcaaggacuucacccacugaaccaucuc

accagcuccacuauggcgguuuucugaaacugaagggaguggggagaaggcgcugagugugaacgggucuggaaggcgggu

auaaccuuuaaggcuggcugguucugagagaggaaagccggcuugugucccauucaggugccaggugcagcaucaaaugug

gcuccacccaacggucaguaacuccgcagacagcaccgugguuaacugccucacagagggggcccagggaccuaguuccuua

aagcccacuuaguuuugagagacgacauggaggggcaagcccagcccuguccagcugcauucacacgaggcccuucuccucc

gaggacccuaccuuuguguuuaguggcugaggcuguguggcucugcuugaagcucuggcuaucaggaaggaccuggcccac

cggcuggcaggacaaacuggcccagugaaggcacuguccggucuccugguggaucacaaggaaaggggcguggcauguccag

auuugaacccuggaugccucuucccaggguaggaagucuaagggucaacaugaauaggugaggguggugguggaaagaauc

ugcaugcaaaaucaggcacucaugucugacaucgucaaacacuauauuuauguagauuuauaugggggugaggcuugggga

gcacuuguauuuuugugugcaauugcaagagcuuccuccacauugcaguguuaaauaucauauggugcuggaccaaccauc

ucuggaacgagggugaggguuugguacccgugacuaugguucucuguguaguagaaacggcuucuugggaagagagagga

agugcuuugaaaugcauccucucuuguuucauucugcaucauggccagguuucucugcacaaagaugcaauagacauucag

gaaaauaagcgcauugcaagaugucaaaagucaugaaaaaugaaaagcaaggucacugcagcugggguguaguguggcugua

gaagcacguuuaugauguacagguuccgggagagggaggaagagagagggagggaaggaggaauggaggaagagagggaga

gggagcaagagaggggggagggagggaggggagaagggagagagagagagaagaaagagagggagggaagaaggaauggag

gaagagagagaaagaggggaagaaagagagggagggaaggagggguggaggaagagagaggugugagggauggagggacag

agagggagggaaggagaaauggaggaagagagaaacagagagauggaggaagagagaaaagucaccaauuauuuuucucccc

agucgcccccugcccucacaccaaggguacccccacuuuucuuucacucaugcacacacacuacacccaauguuuagguaaca

cauguagggcaggcagagccuuugugaaugugcuugguaguuuucugccuuacuucuaaauaaccaaucacacggaugcca

caggguuccuuuagacuguccagggcuccggggcucuuagacuguucccaaugugggugucacaugcaaacaguaagcacc

uucuuguuuguggugcccaggaugcugcagguacuagaaauuccugcacagaccuuugcuacuucuacacagacuuacccu

uuaaaacauuuaauuauauguuuuuuucagcauaaagaucuauuuugauuauuuuuaguugcguguaugggugugugccu

gugugugauuguguaauugucuguaugggaguguaagugccuacagaggcaucggauccccuggagcugccguuacaagua

agggacugggacucagaccugagugguuuggaugagcagugaaugagcguggugagccaucccaccaugcccuauaaacacu

uucaagaggacuuugcuggguauggucaaguugucccccugcgacagccaccccaacuugccauccucauuuacuguacugg

aagcagcaaccaccucugcaauuuugcacaagaaccugagagucugaaagacuuuuguuggcacuggccuguguuccacugg

gguggacacauuaaucuaaaagcuaagaagcucacuucagcuuugccaggcaaccagcacguuugagcacaacgguguagcc

aggaagggugugugggaauuuugaugcuaguuuuucuuuaauuagguugagagugaaaucauggucuguaugcauccaac

aacuuaauccaaaaaguugguugcacggcuccuggaagguuuaccggcaaggaaccugucccauuuuguaaguagguggga

cuggagaguugccaagaagccccccucccugcccccuuccuccuggcagauucugcuuaaaaugagugugguucacugcaga

auagugucaccugucuucagaugucuaaagacauaagaaaggccuagccagcuaagucagaaaaggggacuuuccgguggga

augcauuuuccagucucuaggagaagucuuuauccaaauaaaauuagcauagugguggagucacugccagggcgcuggugc

ggaagcacagcccagagccgaggacguggccauccuccuuccucugaugcaaaguguucucuauccccaguuaccaugagca

auaucaguagcaucgugaaccgggcccgugaugccuuuaacucaggcaagacucgaccgcugcaguuccggguugagcagcu

ggaggcguugcagcgcaugauc

52
AA960603
uuuuuuuuuccaaaaaauuuuauugggggaaacuacaaaacauuuacaguacaauguuua

cagucacaauuuguagugaacugauuccccaaaauauauuacaacucaaguugacuuaau

cuuguuacauucaaaaaccuacuucugucaaaguaguccagagugcacacgcggugcucc

aacuguaccuacauacaaacuaaacaacugcucauuuaucugccauccaggaaagccgga

gacauuccugccucuuuacauugaaaaauaauaguacaaguuuuuggacugucauugaac

aaggcauauucauguaccaccaacauuuc

53
U47737
Sequence below.

ggugauccuccaggaccuaagguuucgguauuaucuucggggccucuucacccggaggugagucugcugagcccgaccuca

gguguucacucgucacgcgagggccuggccacggcggggaagcacugggagagagcgggaggccuugaccgcagcguguag

gaucuggggucccggcgcucugcucccgggugcagagugguuggagcaugcgaggcccucugcagcgugcucuguuccuac

caucaccccacccccaccccaguccuuccugcacguuucuggagaggcaaaggccccugcugagccuucacuggguaccccua

ucucgacuccacuugucugcuugggaucuccaaagggggauacacccucguaaacuagagcaggaggcugggggguggggg

uagggguagggucugaccaguuagauugaggcuggacccuccccagagugaggagcgggaagcucuuugucuuauccagga

uuuugcauaucaaugcugagguucuggugauuaaguagggucccuggcuagcggggguaaccugaacaaccuuccuccgcu

ggccgcuagccaauagacaccuggcuuccgcggaugagcccuuugaguuuguggagguguuccucagguccccagggcccu

gccccguugccugcagauguguggacagacaaaacauuggacucguuuuccaaccacuucaccccuuccuucgcuaguccuc

cgguggacgaugggaugccucauugacuuguuuguggcugugcaugccagagcuuccuagcagacagcucagggcuccauc

guuccuaaaucccacuguguaacgaaaaaaaaaaaaacaaaaacaacaacaacaacaacaacaaaaacaaaaccagaaaugagga

caggcccagcugggcuuggcacugaacuuggccaccuggagcuuuggcuacccacuacaagaugucagcaagucucaggaua

gaagaggccuaaggccaguccuggaagauaccaaaacuucaccuccucuauaccccguuccucuaggagaacuguaagccacc

uuugucucugggacgccccucucccacucaacagauggcaccagucaucuuccuccucaagaggccagugguauucaaaaua

ggauauugaaaccaagcaagcugguccucuccucuacccuaugccaaagacuucugcccaaagggcccagaaaagucccauag

ccaucuggcuggcuagugugcugacugcuacaggugucaguguccccagcgagcagguaguggaguggaggugucuucuu

guggaaauggguccugagccucuaccuuguacagaaaggaauuagugaagcccagaggccuccagcccgugucucugccaca

agagagaggggguggggguggggcuguauuugguucccagggcucagggaagguuuucgguucaugcaugcucauuuauc

ugaccacugucuuaaccccaggacaaccacuuaacuguccacuuccauaucagaguucuugguuccccuuuacuucgucuau

ggagccccugaguuugggaagggguauuaacugaaagguaccauuagaugaacuuggagaaagauuuguaggugccacggg

agauuucagguaaaagcucuuuuaauaauuggcuacaauagcagcaggaggaggccaggaauucugagguagagauuugau

uagcagcacguggagcaaaggagacuucugacuccuacagguuucagaaaguggggagaggcucucagaugaauggcuugg

acugugagguaaguguuaguguagcacgagacuagcuuaaggcuguacaaauuguccgucugauuggugcauugggccagg

uagacacuagauaagcaauugggccuuaacucgaguugucuuaauggcuacccccagggcagcagggagucaauacugcucu

ccugucuggggccugaaugcugaaaccaucuacaaaggggacauaaggcauauuggggagguguagagugggccaggccca

gggucugcugguaucuaugccaggauccugaguggugguggcguagccugucuuuuaaccaacugccucucucacaguagg

cuuacuuuggcuugcgaaccuucagcagaugucugccacuuccaacaugagagucuuccugccugugcuguuggcagcccuu

cugggcauggagcaagguauggagcucugagauaacccugcagccugguccuccuccugaucucucauucuuucuccugag

uagaugcccagggcuccuccugagccagcccuccuaggaacgucuggccuucccaccuccuacucucuagccaacugaccua

guuccccugaugcugugcuggcccagcuacaccuuugucaccucguguugacuuuagccacuccaguaccaaagucugaagu

caguugucauuggcuggcuuuuuucccugacccagggcugagcaugcuguugcuucuugucaguggguuggggaucaagg

gccccacuggaaagucaccuuacccuggaaggcuuccccaggcaauaggcaggugucaccuacagcauugucccuuuugcag

uucauucccugaugugcuucucauguaccgaucagaagaacaauauaaacugccuguggccaguuucaugccaggagaaaga

ccauuacuguaucacguuaucugccgcugcgggcuuuggugaguagcugccuguuucccuagccagggccagggaccugcg

gggcuuuccccauuuccugcucccugucugucuguccccucauccucacuuuccaugcagggaugucaaccuuggcuaca

cccugaacaagggcugcuccccgaucugccccagugaaaaugucaaucucaaucucgguguggcguccgugaacagcuacug

cugccaaagcuccuucugcaacuucagcgcagcuggccucggacuucgugccaguaucccacuacugggccuuggacuccug

cuuagcuuguuggcucugcugcagcugagccccugaccaucccccauguguucuccauauccccccagcucaggaaaagccc

agcuccuuuuaggucccaggggacccuaggaaccuucagcuccuccugggugugucuaguucccccuccacacucucucaac

gucagggcuaaguaccaaacucacccauaccugcucuguugaagugguacuggcuacccuugcuuccagagccaauccuaua

accucccuuggggaaccagcgaaggggugaagaucuccuuggagucucaagaguaccagagucagcgccgaaucuuguggac

acacugacaaggaugucuaauccaaauagauguauaucugugugcucaguguaucccugugugaaugaagccacuuggauu

cuggggugggcaaagaagaccugaaaagauucuacagcagaaggccugugucgccaccaaaaccccucccccugguaucauu

guacccaccuuguacucuguucaggaggcugcccauggaggacugccaccccuccagaugaaggcucccacuacccgaugca

guugagucccauccugcccucucugcccacacuggcuuccugcugcuauucuagugccucaaauaaaccguucacacccuu

54
L00039
cuuccucccucuacagaagaagagcaagaagaugaggaagaaauugauguggugucugug

gagaagaggcaaaccccugccaagaggucggagucgggcucaucuccauuccgaggccac

agcaagccuccgcacagcccacugguccucaagaggugccacgucuccacucaccagcac

aacuacgccgcaccccccuccacaaggaaggacuauccagcugccaagagggccaaguug

gacaguggcaggguccugaagcagaucagcaacaaccgcaagugcuccagccccaggucc

ucagacacggaggaaaacgacaagaggcggacacacaacgucuuggaacgucagaggagg

aacgagcugaagcgcagcuuuuuugcccugcgugaccagaucccugaauuggaaaacaac

gaaaaggcccccaagguagugauccucaaaaaagccaccgccuacauccuguccauucaa

gcagacgagcacaagcucaccucugaaaaggacuuauugaggaaacgacgagaacaguug

aaacacaaacucgaacagcuucgaaacucuggugcauaaacugaccuaacucgaggagga

gcuggaaucucucgugagagcuaaggagaacgguuccuucugacagaacugaugcgcugg

aauuaaaaugcaugccaaagccuaaccucacaaccuuggcuggggcuuugggacuguaag

cuucagccauaauuuuaacugcucaacuaaauaguauaaaagaacuuuuuuuuaugcuuc

ccacucuuuuuucuuuuuccuuuuaacagauuuguauuuaauuguuuuuuuaaaaaaucg

uuaaaaucuauccaauuuuccauguaaauagggccuugaaauguaaacaacuuuaauaaa

acguuuauaacaguuacaaaagauuuuaagacauguaccauaauuuuuuuu

55
D21099
gugggacgggccccccucgaggucgacccacgcguccgggaguacccccgaccuuggcug

cgugcugacucgcuuccuucugccugcccaggcuugcacuccccggggaucugccucugc

aucucuugccuucgcuguuguuucccucucuguccagcuccccucccgcucucgcccugg

agaauggcucagaaggagaacgccuacccguggcccuacggcucaaagacgucucagucu

ggccugaacacguugucccagagaguccuacggaaggagccugccacgacaucugcgcuu

gcucucgugaacugguccaacagccaguccacagcugccccuggccagaaguuggcugag

aacaagagucagggcuccacugccucgcaaggaucccagaacaagcagccuuucacuauu

gacaacuuugagauugggcguccuuugggcaaaggcaaauuuggaaacguguacuuggcu

cgggagaagaagagccguuucaucguggcacucaagauccucuucaagucucagauugag

aaggaggggguagagcaccagcuucgccgagagaucgaaauccaggcgcaccugaaacau

cccaacauccuucaacucuacaacuacuucuacgaccagcagaggaucuacuuaauccug

gaauacgccccucgcggggaacucuacaaggaacugcagaagagucggaccuucgaugag

cagcggacugccacgaucauggaggaacugucagaugcccugaccuacugccacaagaag

aagguaauucacagagacauaaagccggagaaccugcuguuaggucugcagggagaacug

aagauugcagacuuuggcuggucggugcaugccccaucccugaggaggaagaccaugugc

ggcacgcuggacuaucugcccccagagaugauugaggggcgcaugcauaaugaaauggua

gaucuauggugcaucggggugcucugcuaugaacugaugguggggaacccccccuucgag

agcccuagccacagugagacguaucgucggauugucaagguggaccugaaguuccccucu

ucugugccuucgggcgcccaggaccucaucuccaagcugcucaaacauaaccccuggcaa

cggcugccccuggcggagguugcagcucacccuuggguccgggccaacucaaggaggguu

cugccucccucugcccuuuagccugcuccuugguuuuuugucccugucauuuuucagugu

ucuuuguaugucuguguauguguucugagaaggggugggaacuggaaacuauuccuagc

uccaguucuaggggaucugaucucucuucugaccucuacaggcaaaauuaggcaccccugu

ggugcacauauaugcacgccaaacacaugaaguuacaaacaaacaacaaacacacagaua

gugcuggagagauggcucggcaguuaaaagcacuggcugcucuucccaggaaccuagaac

ucaauucuagcacuacauggugcucacggccacugucuguaacacccaguccuggggaau

cuggggccuucgagccucugcaggcacuaggcauggaugugguauacauguaugcaggca

aaacacccaugcacugacuuuuaagaaacccucuagucugauuccuuucaauuugucaaa

uguugaauguuauuuuuaaaauauuauaagccauuuaauacaauuuuucuuugaaacaug

guauagccuagucugucuuaaauucagaaaaauuaugaagaacaacauuuuauaauaaag

ucuuaaauguuucauguuuuug

56
AF026481
Sequence below.

uugccuaggaagggcgcgucgucucucugcucguccggcugugacggggaagggucccgcugcguuuuggucacugugag

uaccaaguuugggggauccccgagggacucucgagagcucauuuuagggaugcaggggcuacuccccggugguagagagcu

uucuaguuggcaggagguuucguauguggaggaggccagcuuaggcagaaagcacauguucucagagaugaggacaagacu

aagaccgucuaaucccugaucuuuaccuuccggcccgcugaccugggccuggaugcuaaagcccucugcuuucgucuaaaca

gcgcuaaauaguaaacaguauugccuaagauaaaugcggauuauuacccgauucagugucgggaaaaggcagcuaggagaga

gcggcuggcacgugguaagcacacgguaaguuucgguuaaauuaaaacaaccauccguugagcaucucuuagcaagcuccuu

ccacccuucaaacaaucagugauagugcgucuguuucacugauuagggagcuaaggcuccaacagcagcaaaggaacuaauc

cgccucugaucaacauggcguuucuuacagggcauuccuuauacgcuuucccacgugcguaacaggaaucggguguucccg

gguuuuguuuuguuguuguuguuuuuguuuuguuuucuuagugaaagaggcagggugggcuccaggccgcugaggauua

auaaagagauucuaugaggaggaaauaacaggcaggugguaugaucgaggcaaggcccugaggaaggcuugggugggguga

guagaaccagagccggaaguccacucagcagccuggggcacuuaaagcuucugcuggggcaaaugguaaggcggcguaaggu

cacauuccuuucauuucuuccagacucaggaggagaccacaccuuccggagaaccaggccugaaccgagguacuauuuugua

gcucucagaagccaggacucugcaacacuguuugcugccuguggaucuucuauauucacagugucccaguugcuucugauc

uaccacuguuagauacuucugccacccauccuaagaguauaguuguucuuggaaaggagucucagcugcugucagcaggag

ucccucauucgacuccugugguugcccuuuccaccaugccaaagaauaaaggcaaaggaggcaaaaacaggcgcagagguaaa

aaugaaaaugaaucugagaaaagagaguugguguuuaaagaggaugggcaggaguaugcucaggugaucaaaaugcuggga

aauggacgguuggaagcaaugugcuuugacggugugaggaggcuggccauauaagagggaagcugagaaagaagguuugg

auaaauaccucggacauuauauugauuggucuacgagacuaucaagauaacaaagcugauguaaucuuaaaguauaaugcag

augaagcaagaagucugaaggccuauggagaacuuccagaacaugccaaaaucaaugaaacggacacauuugguccugggga

ugaugaugaaauccaauuugaugauauuggagaugaugaugaagacauugaugacaucuagccugaccuaagcaugcuacc

uuccaaguucucugaagauagcuccacacaguggcaucuugaccuucaucuguuaaguaaaacuucauggcauguguaugac

uuguuaaugcaagcuaaugaauuuuauuuuuugaaguacuauauuucuuugaaaaccaaagauguugaguuaucaucuuaa

gugacauguuaacacuuugugcuuuugaauauaauugaaccuagcgcacagcagugagcacuguuaagagacugccuuucc

auuuguagcuucauuucuggcacgggaguguuuugugucagcaguucugccagguggccaucgaugagcugaaguaaguc

cuaguccagcacaucugcuucaggccuuuguacucuagucaucuggcugcguucgagacuucucagcagaacuuauagaug

uguacggcugcacuuggagucagacaagauauggcuacuuuuguacuuauggagccaugccauuuuauacuuucacguugu

auacauucguuugacccuuuaaguuguugccacccauaaaaaggcaucuuacagugcaguuuuuaaauuacauggguagca

auuuugaguuuuaaaaauuagucauugcagaaauuaaauacuuagaggagauaauccauuaucuugauuuuaggaauauaa

uaguugacaauguuuauauauaauuuuacuucucuaaggcauacccaaaaauagaaaaugaaaaagagcagugagucuguuc

ugaugcuugcauugcauagagaaguuuuccaacaaagcagcuguuaauaacacauaaaauauguuuuacuuugcaaaguagg

uuguguuaagucauuuucaaaaaguuaccuacuauaucgaggcucuggauaauuacuauguguugauuaaaguuaguuaca

gaauuguacaagcuaagauuuuccuuaaacuaagcuuagguuaaagggagaggagccacagcucaaugaaaacacgguuccug

uuuucuaaauggaggcgcccagaaacacaauaaaacauguugguacaaaaaaaaaaaaaaa

57
J04596
caugaucccagccacccgcucgcuucucugugcagcgcugcugcugcuggccaccagccg

ccuggccacaggggcgccuaucgccaaugagcugcgcugucagugccugcagaccauggc

ugggauucaccucaagaacauccagagcuugaagguguugcccucagggccccacugcac

ccaaaccgaagucauagccacacucaagaauggucgcgaggcuugccuugacccugaagc

ucccuugguucagaaaauuguccaaaagaugcuaaaagguguccccaaguaacggagaaa

gaagacagacugcucugauggcaccgucuggugaacgcuggcuucugacaacacuauaca

auuucuuuugaggguccuauuuauuuauguauuuauuuauuccacaaagugugugguuu

uuauuuuacauuaauauuuaacaguguggauacauuucaucgaugguaguucaguucugc

uuguucaguuuaaagaugguaggcuuaaaauauuucauuaaaacuaauauuuauugggag

accacuaagugucaaccacugugcuaguagaaggguguugugcgaaaagaagugcagagag

auagaguuuaguauuauguuuuguauguauuagggugaggacaugugugggaggcugug

uuuguaugucuugaaaagaaugucaguuauuuauugaaagucgucuuucauauuguaug

gucaacacgcacguguugacgcuucccuuggacauuuugugucuaguugguagcccauaa

ugggcuuuuacauucuuuaacccuguuucuccuggucucgucucgcucgggacagagacg

uucaaaggacuguuacaaaugaaguaaaaauaaaaguuuuauuaag

58
X81580
cgucucccgcauucgucugggccgugcaccugcccgcuagcucgcugcacuaccguugcc

cacaagccaacaugcugccgagauugggcggccccgcgcugccgcugcuccugccgucgu

ugcucuugcugcugcucuugggcgcgggcggcugcggccccggggugcgcgccgaggugc

uguuccgcugcccacccugcacgcccgaggcucuggccgcuugcgggcccccacccgacg

cgcccugcgccgagcuggugcgagagcccggcugcggcugcugcuccgugugcgcacggc

aggagggcgaagcaugcggcgucuacaucccgcgcugcgcccagacgcuacgcugcuauc

ccaacccgggcuccgagcugccccugaaggcgcuugucacaggcgcggguaccugugaaa

agagacgcgugggcaccaccccacagcagguugcagacagugaugacgaccacucugagg

gaggccugguggagaaccacguggaugggaccaugaacauguugggaggugguagcagug

cuggccggaagccccucaagucaggcaugaaggagcuggcuguguuccgggagaagguca

augaacagcaccggcagaugggcaagggugccaaacaccucagucuggaggagcccaaga

aguugcgcccgccucccgccaggaccccuugccagcaggaguuggaccagguccuggagc

ggaucuccaccaugcgccuuccggaugaucggggcccccuggaacaucucuacucccugc

acauccccaacugugacaagcauggccgguacaaccuuaagcagugcaagaugucucuga

acggacagcgcggggagugcuggugugugaaccccaauaccgggaagcccauccagggag

cucccaccauccggggagaccccgagugccaucucuucuacaacgagcagcaggagacug

guggggcccaugcccaaagugugcaguaaaccccagccagucggugccuggcuuccccau

cccgaacaccagcagaaauggagggcgucagggugacggguguggaggaguucccaguuu

ugacacauguauuuauauuggaaagagaccaacacugagcucagaagccccccucugacc

ccccccagcggcuguuaacugaaccucccuugcuucuguuagagaggggaagggugguau

ggagggcacuggguacaggccugggaauggggaaagaaauuuuuauuuuugaaucccugu

gucucuuuuacuuaagauuaaaggaaggaaaaauaaaaaaaaaaaaaaaa

59
AI314958
gaugugaaaaacguuuuuauuauaaucucuuaaacuuucaguguauauuuucauuacaau

cauugguacaauaaauauggaaaugcugagcagacaauuaucacaguggccuaugggcug

agggacagggacccaggaauacuguuacccuggauacuuccucagggccaaucaggaggu

cuucaaagaguauugagagggagagggauagaaauauuauuaagacugucagugcagcaa

cuuuuagaaugucuauuaaagccauggauacaggauuuacgauaacagaagauggauacu

aaaaaagaacagagacucaaguucuccuguaagaggcagaagaaacauugcagaagccag

ugccuuccucggguccccagugugugcccccauccacccacgcauuguguuggucaucuc

caccugcccugugcccagcccugugcccacccagguucuccuaggcacccaccuugcacc

ucgcacg

60
AF058798
gaauucugcgcgguuuugcauuuuuugggucagauuggcuuuuuacaugauuacgaagc

uccaacgacuagaccacagggaccgucgccuuggcggccgagcagucguauccaacuugga

gacagccaguucgccgugugucugucuguccuucaucgcagucauggagagagccagucu

gauccagaaggccaaguuggcugaacaggccgaacgguaugaagacauggcagcuuucau

gaagagcgccguggaaaagggcgaggagcucuccugcgaggagcgaaaccugcuuuccgu

agccuacaagaacguggugggcggccagagagcggccuggaggguccuguccagcaucga

gcagaagagcaacgaggaggggucagaagagaagggccccgaggugaaagaguaccggga

gaagguagagaccgagcucagaggugugugcgacaccguacucggccugcuggacucgca

ccucaucaaaggggcuggagaugcagagagccgcgucuucuaccugaagaugaaggguga

cuacuaccgcuaccuagccgagguggccacuggcgaugacaagaagcgcaucaucgauuc

ugcccggucagccuaccaggaggccauggacaucagcaagaaggagaugccgccuaccaa

ccccauccgccugggccuggcccugaacuuuucagucuuccacuacgagauagccaacag

ccccgaggaggccaucucgcuggccaagaccaccuucgacgaggccauggccgaccugca

cacccucagugaggacuccuacaaggacagcacccucaucaugcagcuccugagagacaa

ccugacgcuguggacagccgacagugcuggggaagaggguggugaggcuccggaugaccc

ccacaucugaagcagcggaaaaacaacccggguuggcuuggccuuccaguccccagccug

gcauagaggauuaaaagggagugggauuuugccuuucccaaacccugaauguucagcaac

accuugggaaggucuuucgaagggggcgcagccaagcugaagccaccagggcagggaauu

uaauuuuucguguagcuguuuggguggguguuucccaaaaccaucccaccccuguuuuuu

gaacccccuccccaauucuucccccugagccucccucgggcaccuguugcuuuuggaucc

gaauaauccaggagguuccccacccuguggcugagaaauggacuguggcaagggcugugu

gugugugagagagagggaaacucugugugugugugugugagagagagagagagagugaa

ugagagggaaaaaguuugcugggugugaccaugguaccaaucaauaaaguugcccuguga

gacucaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

61
AW046627
uuuuuuuuuuuuuuuuuaaauaccaaaacauuuaauugaaauaccuguauaaaaaauaug

aucuucagacauuucacacuuuugaacuuauacaaccccaccccugaugcuuagucacac

cagggucacagaaacacagcugcuaaaauaaauuaagggcuugagacucugucccccaac

cccagcuuucagagccagcaagcagacuguacaaggucaauaauuuaaaccccuccccag

cgcagagugcucagggugacagggucuc

62
AI848050
uuuuuuuuuuuuuuuuuaauguaacgaccggugugcuucaguuuguuuagcagaaccac

ucucuugaaucacauuaacuuuugagauuuaaaaaaaacaaaacaaaaaaaaaaaaaaaca

acaaaaaaaaaaccaacccuccauagcacagcugucuuuuaugcaagcaagagcacaccu

acuccagcaugauuugucaucuaaagacuugaaaacaaaacaacaacaacaaaaaguuac

uuauagucaauggauaagcagaguccgaauuuacacuaaucaagacagaccuucgagggg

ucacgauaaguccggaacuuucaaaccuugcuucguaugaauuguacuaucugaacauaa

acugcacuuuuauuuuc

63
AF065441
augagacuccacagccucauccugcucuccuuccuucuccuggcuacucaggcguucuca

gaaaaggucagaaagagagccaagaacgcaccacacagcacagcggaggaggggguagag

gguucagcucccucguuagggaaggcccagaauaagcagagaagcaggacaucuaaaucu

cugacgcauggcaaguuugucaccaaagaccaagccacaugcagaugggcugugacugag

gaggagcagggcaucagccugaagguccagugcacacaagccgaucaggaguuuucuugu

guuuuugcuggugacccaacugacugccuuaaacacgacaaagaccagaucuacuggaaa

cagguugcccgcacgcugcgcaaacagaaaaauaucugcaggaacgccaagagugucuug

aagaccagagugugcagaaagagauuuccagagucuaaccucaagcuggugaaccccaac

gcacguggaaacacgaagcccaggaaggagaaagcagaggucuccgcaagggagcacaac

aagguccaagaagcugucuccacggagccaaacagggucaaagaagacaucacacucaau

ccagcugcgacccagaccauggccauuagagauccagagugucuagaggauccagaugug

cucaaccagaggaagaccgcccuggaguucuguggggaaucuuggagcuccauuugcaca

uucuuccucaacauguuacaggcgacaucaugcuaa

64
AF022992
Sequence below

cgggucgacccacgcguccgcccacgcguccggcggagcuucuggguugcgggccgaaacggcaagcggauggagggcgcuc

gaacggccaggugucgugauuaaauuagucagcccucagagacaggcguccuaccuccuuuauccagaccucaaaagccccg

uugugcacccgugguggcuucuucaccuucccuguuucguccuccacuguauggcccagacaugagugguccccuagaagg

ggccgaugggggaggagaccccaggcccggagaaccuuuuuguccuggaggagucccauccccuggggccccgcagcaccgg

ccuuguccaggccccagccuggcugaugacacugaugcaaacagcaauggcucaaguggcaaugaguccaacggacccgagu

ccaggggcgcaucucagcggaguucucauaguuccucuucuggcaauggcaaggacucagcucugcuggagaccacugagag

cagcaagaguacaaacucacagagcccauccccacccagcagcuccauugccuacagccuccugagugcgagcucagagcagg

acaacccaucuaccaguggcugcagcagugaacagucagcucgagccaggacccagaaagaacucaugacugcacuucgggag

cucaaacuucgacugccaccagagcgucggggcaagggccgcucugggaccuuggccacacugcaguacgcucuggccugug

ucaagcagguucaggcuaaccaggaauauuaccagcaguggagucuggaggagggugagccuugugccauggacaugucua

cuuacacccuggaggaauuggagcauaucacauccgaauacacacuucgaaaccaggacaccuucucuguggcuguguccuu

ccugacaggccggauugucuauauuucggagcaggcagguguccugcugcguugcaaacgggauguguuucggggugcccg

cuucucagagcuccuggcuccccaggaugugggugucuucuauggcucuacuacaccaucucgacugcccaccuggggcacu

ggcaccucugcagguucaggucucaaggacuucacccaggaaaagucugucuucugccgaaucagaggagguccugaccggg

auccagggccucgguaccagccauuccgccuaaccccauaugugaccaagauucgggucucagauggagccccugcacagcc

gugcugccuacucauugccgagcgcauccacucugguuaugaagcuccccggaucccuccugacaagaggaucuucaccacc

cgacacacaccaagcugccucuuccaggauguagaugaaagggcugccccacugcuggguuaccuuccccaggaucuccugg

gggcuccaguacuucucuuucuacauccugaggaccgaccccucaugcuggccauucauaagaagauacugcagcuggcagg

ccagcccuuugaccauuccccuauucgcuucugugcucggaacggggaauaugucaccauggacaccagcugggccgguuu

ugugcaccccuggagccgcaagguggcuuucguguugggucgccauaaagugcgcacggcaccccugaaugaggacgucuu

cacucccccagcccccagcccagcuccgucccuggacucugauauccaggagcucucagagcagauccaucgauugcugcugc

agccugugcacagcuccagccccacggggcucuguggaguuggcccucugauguccccugguccucuacacagcccuggcuc

cuccagugauagcaaugggggggacgcugaggggccugggccuccugcuccagugacuuuccagcagaucuguaaggaugu

gcaucugguaaagcaccagggacaacagcucuucauugaaucucgggccaagcccccaccccggccccgccuccuugcuacag

guacauucaaagccaaaguccuucccugccaguccccaaaccccgaacuggagguggccccaguuccugaccaagccucguua

gccuuggccccugaggagccagagaggaaagaaaccucuggcuguuccuaccagcagaucaacugccuggacagcauccuca

gguauuuggagagcugcaacauucccaguacaaccaagcguaaaugugccuccuccuccuccuacacugccucuucagccuc

ugaugaugacaagcagagggcagguccaguuccugugggggccaagaaagauccgucgucagcaaugcugucuggggaggg

ggcaacuccucggaaggagccaguggugggaggcacccugagcccgcucgcccuggccaauaaggcagagagcguggugucc

gucaccagucaguguagcuucagcuccaccaucguccaugugggagacaagaagcccccggagucggacaucaucaugaugg

aagaccugccuggccuggccccuggcccagcccccaguccggcccccagccccacaguagccccugacccaaccccagaugcu

uaucgcccagugggucugaccaaggccgugcugucccugcacacacagaaggaagagcaagccuuccucaaccgcuucagag

aucuuggcaggcuucguggacuugacaccucuucuguggcccccucagccccuggcugccaccauggccccauucccccugg

ucgccgacaccacugccgaucuaaagcaaagcguucccgccaccaccaccaccagaccccccggcccgaaacucccugcuaugu

cucccauccuucaccugugcccucuucuggacccuggccacccccaccagccacgacccccuucccagcaaugguccagcccu

acccacucccaguauucuccccucgaggaggaccccagccccuucccccugccccuacaucuguguccccugcuaccuucccu

ucucccuuagugaccccaaugguggccuuggugcucccuaacuaucuauucccuaccccaccuaguuauccauauggggugu

cccaggccccuguugaggggccacccacgccugcuucccacucgcccucuccaucccugcccccaccaccucucagcccccccc

accgcccagacuccccacuguucaacucgagaugcagcuccccacuccagcucaaucugcugcagcuugaggaguccccccgc

acggaggggggcgcugcugcaggaggcccaggaagcagugcugggccccugccucccagugaggagacugcugagccagagg

ccagauugguggagguuacugagucguccaaucaggaugcacuuucaggcuccagcgaccugcuggagcuacugcuccaaga

agacucucgcucgggcacaggcuccgcagccucaggcucccugggcucuggccugggcucugggucugguucaggauccca

cgaagggggaagcaccucagccagcaucacccgcagcagucagagcagccauacaagcaaguacuuuggcagcaucgacucuu

ccgaggcugaagcuggggcugcucgggccaggacugagccuggggaccaggucauuaagugugugcuccaggaccccaucu

ggcugcucauggccaaugccgaccagcgugucaugaugacauaccaggugccguccagggaugcagccucugugcugaagca

agaccgggagaggcuccgggccaugcagaaacagcagccacgguucucagaggaccagaggcgggaacugggugcugugcac

uccuggguccggaagggccagcugccucgggcccuugaugugauggcguguguggacuguggcagcagcguucaagauccu

ggccacucugaugacccgcucuucucagaacuggauggauuggggcuggagcccauggaagaggguggaggcgaggguggu

gggugugguguuggcgguggugggggugaugguggugaggaggcccagacccaaauuggggcuaaggguucaagcucuca

ggacucugccauggaggaagaagagcaaggugggggcucauccagcccagcuuuaccugcagaagaaaacagcaccagcuag

auccauuuuggggccgcuuacagcagucuaaugagaggcuuccuuucgaccauguugggguucuuauaacucaagauacag

cuggaccaaccaauaggaaacugccccagcuucucccaacauagggggcuggacccccauuaccagcccaggcacaggagcug

ccucuagcuucuuagcagaguggaaguucucagccccauuuggaggauuguccacgcccgucccacugaggagacgggcgg

gucuucgguuaagguugcugacaagcugcugaaguggucuguccaaaucccagcugagccugagucccagucgcaggguug

gggcugcacuuauuuauuugggagagacagcucacucucccaccucaccccaagaugggaggaggggaaccugggaucugu

guaggauccagguccgugaaccccuagcugcuccagggugggggagguugguggaccauggagucccuggugcugccccuc

aggugggacccagguguucucagcucuacccucuaccaaugacauuuguguuuuugauauugugucuguuauuuuuuuuu

uaauacaaaaugacaaaaugaaaaaccaaaaa

65
AF064088
Sequence below.

gacagcggagcgcgguggcgucgacgucuagugucucagugcucccgucuguggcuaacuaagcagccagcagccaggcagc

ucgcgaccugcggccaggcagccaaccaugcucaacuucggcgcuucucuccagcaagcuucggaggggaaaauggaacuaa

uuucugaaaagcccagagaggggaugcaucccugggacaaagcugagcagagugacuuugaagcgguggaagcgcucauguc

caugagcugcgacuggaagucucauuucaagaaauaccuugaaaacaggccugucacaccagugucugauaccuccgaggau

gacagcuugcuuccagggacgccugaccuucagacagucccagcauuuuguuuaacgccaccuuacagccccucugacuucg

aacccucccaagggucaaaucugacugcaucagcgccaucuacuggccacuucaaaucuuucuccgaugcugccaagccucca

ggcgccacuccuuucaaagaggaggaaaagaauccuuuagcugccccuccucuuccuaaggcucaagccaccagugucaucc

gucacacagcugaugcccaacugugcaaccaccaguccugccccgugaaagcagcuagcauccucaacuaucaggacaauucu

uuccggagaagaacccacggaaauguugaggcuacucgaaagaacauacccugugcugcagugucaccaaacagauccaagcc

ugagcccagcacaguguccgauggugaugagaaggcgggcgcugcacuauaugacuuugcugugccuuccucagagacagu

aauuuguaggucucagccagcuccuucguccccagugcagaagucaguacuggugucuucaccuacaguauccacuggggg

agugccaccccugccugucaucugccagaugguuccccuuccugccaacaacucucuuguuagcacaguuguccccagcacu

ccuccuagccagccaccagcugucugcucaccuguguuguucaugggcacucaggugccugagggcaccgucguguuugug

guaccccagcccguugugcagagcccaaggccuccaguggugagccccaguggcaccagacugucucccauugccccugcuc

cuggauucucuccuucagcagcaagggucacuccucagauugacucguccagaguaagaagucacaucuguagccacccagg

guguggcaagacuuacuuuaaaaguucccaucugaaggcccacgugaggacacacacaggggaaaaaccuuucagcugcagc

uggaaaggcugugaaaggagguuugcucgcuccgaugaacuguccagacaccggcggacacacacaggugagaagaaguuug

ccugucccaugugugaccgucgguuuaugaggagcgaccauuuaaccaagcaugcccgacgccaccuaucagccaagaagcu

gccaaacuggcaaauggaaguuagcaaguuaaaugacauugcucugccuccgaccccugcuuccgcacagugacggccagaa

gauggagacgcagaauaaacuuuggucagagucaggagccagugauggugucaagugcuucugcaaggcuguggcccucca

aaagggccuaaaguagaagcccuggccugggggaggccccgccugggugaaaugacaagaagugcuucagccacaggcaggu

cacagaggacagggcucaguucuuaccacagagagagaggagaacccuuuuauuccucccuuauuuuagucuggaaaguuuc

ggcugaggugagcgcagcacagguuuugaaucacauacacauuggggacuuuguuuuugccauuuauacuugagaccagcu

uugcagugugauucuuucaaaggauugguuucaagaauauagaggcuggaaauuacgguacagaaauggagcuagaaaaug

aguuuguguuacacagagaugucaucuucuccuagaguuaucuuguuucuuauuccuagucuuuccagucaaauccgugga

uguagcuaaguauaucuaaaacucauuuuuccacuauuguugguauuugaaguugaacagcuguacauugcugugggggag

ccaaaggauuggaacccucauuaauuuaauugcuuggaaaugcagcuaaaauucuucuuuggcauuuuguuuugaaaguuu

aggcauuuuacucuacuuuagauuuuaguuugcuugcaguuuuuuguguagauuugaaaauuguauaccaauguguuuuc

uguaggcuuaaaauacacugcacuuuguuuagaaaaaaaucuggagaugaaaauauguauuauaaagaagagaugucaagaa

uuugagauaacuccuugagaaaguuggcuuuaugucaucagcaaaggacacuuaacgucaagcauacacugugguuuuuuu

guuuuuuuguuuuuuuuuuucaaauuagaaaguuuaaugaccguuacagauggacagugucuuuuuauuuauaggaguuu

uucaggaugucagaguagauagguaggaaaauuguuauuagaacauucgcuucuaccuugaaaaggauguuaaugugguca

uguucuuagcaccacagugucugggcaucugggaaacuccgagacuuuuuuaaagugucaugaugugaucacaccugcagu

uuggggcaucgaauccagggccuugcaugucuucuguaagagcucucaucgcugaccuguaucccccgcaagagcaaugacu

uuugcuaacaguauuucuuuucuguuguaaaguggacagaugauacacuuggucgcaaagguaaauuauucaaaauccaca

gugaaaaccucaccacacuuucccauuuaaacuauuuccauaucucagagguuucugacaugcaaacuugaacccuugaaag

aagaguuuucuuaaaaauuauaaaaaaucacgaguuacaauuugcacaauauuuuuuguugaacuuuauaccuuguuuaca

auaaagacuuuucuuug

66
AI787713
uugucanuugcacgacagaaacugcaggaagaugagaugcgccgggcugcggaggagcgc

aggaggguaaaggcugaagaguuagcugccagacaaaggguucuagaaaaaauugaaagg

gacaaagcagagagagccaagaaguauggugguaguguggguucucggucauccccacca

gcaacagacccagguccuguuccuucuucucccagccaggagcccccuacuaagcgggag

uaugaccagugucguauacagguuaggcugccugaugggacuucacugacccagacuuuc

cgggcccgggaacagcuggcagcugugaggcucuacguggagcuucaccguggggaggag

ccuggacaggaccaggacccugugcaguugcucaguggcuuccccagacgggcuuucuca

gaggcugauauggaacggccucugcaggaacugggacucgugccuucugcuguccucauu

guggccaagaagugucccagcugaggguucuccaucccaccaucuc

67
AI853531
uuuuuuuuuuuuuuuuucacaaauaaguaauauaacuuuauuaaaaugaaaagacaauau

ucaaaauaaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggag

aucagugcauuuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuu

uaaauagcucaaauaaugucauucagcaguuuaaacugaacagcuuguugggacauggca

gcagugucccugcuagcaagcaccuucucuuuguguuuaucugcacaagauaaacaauca

gaggauguaaaaacugaacacaaacugcgugucucacugaaucucagggcagugaagcag

ccagcgugaguuuucaaagcaggaagaugcugaagugaccucuggcauuaagacguucug

ugcua

68
X14678
Sequence below.

uucauuggaaagcacauugcucuucucaguaauuucuuuaguaucuucaugaauuuuuuccuuuugcgucguuauuucag

caauucuaucugcagaucauaaagguaguauugacagaugugauucuuuuucuuaaacauuucauuuccaggguaaggaac

ucaauggcuauguuuuucucucccucuagugcauccuucuccuuuucuaccauuuucacucuauuuaacuucaucauguuc

agucuggccuuuggguuucaucauagcaaucuguucaacuucacccugcaagauuaaaaaucgauuauggucuaagucaau

gccauggcuucuaaggagauuuccaacaucuuuaaacgucuucuucuucccacuuaugugguagacagaagugcuaucucu

guaggcgguucuggauacauagaaguugcuguuaggaaggacuucguaaucaucuccuuccuuaucaauuaucuuuugaaa

augaacuucuacaguacaacucugaauauccuuguguucaucagaauuauguaucaguaccgauagcuuuuuagaccuuau

uuuuugugcucgauagccaaacacaaaaagcauggaaucaauaacauuggauuuuccacugccauuugguccaauaauacag

gaaaagcgcuuauggaaaggucccacaaguuucucuccagcauaggacuugaaguuuugguuuacaauaugaguuaucaug

agacgaggagcuccagcuucacuggccauggcuggagguggggguggagggauacuauucaaaaucuccucuaaacuucug

uuauccagcuccucaccuggaggcuuugcgggugcagcgcuccccucaccuacuucgccuacugcaacucccaccaccuccu

cucgauacaagaccgagcucugucggaccuacucagaaagcgggcguugucgcuacggggccaagugccaguuugcucacgg

ccugggugaacuucgccaagccaaucgccaccccaaguacaaaacggaacucugccacaaguucuaccuccagggccgcugcc

ccuauggcucucgaugccacuucauccacaaccccaccgaggaccuagcucucccuggccagccccaugugcugcgacaaagc

aucagcuucuccggcuugccucaggccgcagaagcucgccgccaccuccaggcuuuucuggcccuucccuguccucuuguuc

cuuuucgccuuccagcuccccaccgcccccuggggaucuuccacuuuccccuucugccuucucugcugccccugggaccccu

gugacucgaagagacccuaaccaggccuguugccccuccugccgaaggucuacuacccccagcaccaucugggggcccuugg

guggccuggcucggagcccaucugcccacucucugggauccgauccugaugacuacgccagcagcggcagcagccugggggg

gucagacucaccugucuuugaggcagggguguuugggccuccccagaccccugcacccccaaggcgucuccccaucuucaau

cguaucucugucucugagugacaagugccuaccuacccaguauggaucagcuagaucucaaagagagggcagggacugcuca

uugcuguggggaccuggggcacuccucuaaguuaauaagucccaucuucuggacauuccaagaugcaauaacccauuucccu

ggugcugggcuggggcaggucccuaguuugcaaauucaguguuuggguggauccguuccuaggguaccuaagauguuuga

gggagacaguugacaguuggucuuccaggccccaagucuucuguuguuuuugagauaggagcuuauuaugguaccccaggc

uggcuuugaacucaauauaauccugccuuagccuuuuccaaguucugggguuacagguaugcaccagccccucugcaacucu

ggucuccuggaaucuuaagugcugugaagagccggcucccacaauacuauccuaauuuuuacuagacccugaaguucagug

uccgguggucgaagccucuccugagaauccuggugcucaaauuucccuccuaaagcaaauagccaaagccauugccaaaucc

cuucucccccaaccagugggcccuuuauuuaugacgacuuuauuuauuguauuaagauuuuauaguauuuauauauauugg

gucgucuacuccguuuuucuuuuuguaauguuaaaacugauacuguauuaaguauaugcuauaauauauuaauauauugcu

69
AI854358
cggacgcugcagaccugaccgacgugcugugcgaguucgacgcggugcuggccgacuucg

cgucgcccuuccacgagcgcacuuccacuaugaggagcaccuagagcgcaugaagcggcg

cagcagcgccagcgucagcgacagcagcggcuucagcgacucggagagugcagacucagu

guacagggacagcuucaccuucagugaugagaagcugaauucuccaaccaacuccucucc

agcucuccugcccuccgcugucacuccucggaaagccaaauuaggugacacuaaagagcu

cgaagacuucauugccgaucuggacaggaccuuagcauguaugugaagcaaggaguuugg

gguc

70
X67668
ccgggccgaggagaagucugcaaaacaagaggcuggggauugccuuagcgagaaaucagu

ucucuuaggagguuagggaaggaagucuuucucuggaggucugagggaagcgcucguguc

agaugccggguugucauggguaagggugaccccaucaagccgcugggcaaaauguccucu

uacgccuuuuuugugcagaccugccgggaggagcacaagaagaagcaucccaauucgucg

gucaacuucgccgagaucuccaagaaaugcuccaagagauggaagaccaugucugcaaag

gaaaacucgaaguuugaagauuuggccaagagcgacaaagcuuguuauuacagggagaug

aagaacuauguuucucccaaaggugauaagaaaggaaagaaaaaagauccaaaugcuccg

aagagaccaccgucugccuucugccuguuuugcucugaaaaucgcccaaagaucaaaauu

gaauacccgggccugucuauuggagauacugcgaagaaacugggugagauguggucugag

cagucugccaaagagaaacaaccguaugagcagaaagcagcuaaacuaaaggagaaguau

gaaaaggauuuugcugcauaccgugucaagggcaaaagugaagcaggaaagaaggguccu

gguaggccagcaggcucaaagaagaaugacucagaagaugaggaagaagaagaggaggaa

gaugaagagggggaagaagaggaugaagaauaaguggcuauccuaaaguguggaguauau

gugcucaggcaguuauuuugcuaagaauguaaauucaagcgcagcucaacauuagcucca

guaggaa

71
K02236
aucacgcuccuagaacucuucaaaccgaucucucgucgaucuucaa

ccgccgccuccacucgccauggaccccaacugcuccugugccuccgguaagggggacugc

ugacgggauuucugggagagcuagacaggcuuuuuggccccuccuuuaguaauuacuuua

aggguacgaccggcuaccccuuccgaaugaauucugaagcacuccugcuccuuuaaacua

guccuugagauaguggcucgccuacccgggugauuugccucaccuuccuaggagaacagc

guucagguacucccgggucccacucaaccgcgcucacugacugccuucuacuuuuagaug

gauccugcuccugcgcuggcgccugcaaaugcaaacaaugcaaauguacuuccugcaaga

aaaguaaguuggaucuucucugccauuuccccgucacucuccuggggucccuagcccgcc

gcgccgcgccuucccucccgggagcguucagguggugugccucugacaagguuucucgcu

cacguucaacucuucucuccccacaggcugcugcuccugcugccccgugggcugugcgaa

gugcucccagggcugcaucugcaaagaggcuuccgacaagugcagcugcugugccugaag

gggggcggagggguccccacaucuguguaaauagaccauguagaagccuagccuuuuuug

uacaacccugacucguucuccauaacuuuuucuauaaagcauguaacugacaauaaaagc

cguugacuugauu

72
X51829
Sequence below.

gcucugaguuuguggaagauuacaugcgauaucccgcgcgaccccgcaucccuuugccggccgggacagccuuugcuacagc

cugugaaacauugcguccccgagccccacgccugagggcgacaugaacccgcuggcuucgcgagcaguccggacccacgauc

gcuuuuggcaaccagaaccggcgcuucagcccccggggugacgugcagcccgccgcccagacacauggccccgagcccaagac

cccagcauguccugcacuggagggacgcccacaacuucuaucuccuguccccacugaugggcuugcucagucgggccuggag

ccgccugaggggcccagaagucccagaggcauggcuggcaaaaacaguaacaggagcagaucagauagaagcugcggcucug

cugacaccuaccccugucucugguaaccuccucccucauggggagacugaagaaaguggaucuccugaacagagucaagcag

cccagaggcucugccuuguggaagcugaaaguuccccuccugaaacuuggggacuuucaaauguugaugaguacaaugcaaa

gccaggacaagaugaccuuagagagaaggaaauggaacgcacagcuggcaaggccacacuacagcccgcuggccugcaagggg

cugauaagaggcuuggggaggugguggcuagagaagagggaguggcugagcccgcuuaucccacaucacagcuggagggug

guccagcugagaaugaagaggauggagaaacagugaagacuuaccaagcuucugcugcuuccauagcuccgggauacaaacc

cagcaccccugugccuuucuugggggaggcagaacaucaagccacggaagaaaaaggaacagaaaacaaggcugaccccucca

acucuccuucuucaggcucccacuccagagccugggaguacuacucuagagagaagccuaagcaggagggagaagccaaggu

agaggcacacagggcagggcagggucacccuugucggaaugcugaggcugaggaaggaggaccugagacaacuuuugucug

uacuggaaaugccuuccugaaggccuggguguaucgcccaggagaggacacagaggaagaagacaacagcgauucggauuca

gcugaggaagacacagcucagaccggugccaccccccauacaagugccuuccugaaggccuggguguaucgcccaggagagg

acacagaggaagaagacagcgauucggauucagcugaggaagacacagcucagaccggugccaccccccauacaagugccuuc

cugaaggccuggguguaucgcccaggagaggacacagaggaagaaaacagcgauuuggauucagcugaggaagacacagcuc

agaccggugccaccccccauacaagugccuuccugaaggccuggguguaucgcccaggagaggacacagaggaagaaaacagc

gauuuggauucagcugaggaagacacagcucagaccggugccaccccacauacaagucccuuccugaaggccuggguguauc

gcccaggagaggacacagaagaugacacagaagaggaagaggacagugagaauguggccccaggugacucagaaacagcugac

ucaagccagagucccugccuucagccccagcguugucuaccaggagagaagaccaagggacguggggaagagcccccucucu

uccagguggccuucuauuuacccggagagaagccagaaucaccuugggcugcaccuaagcugccccuucgacugcagaggcg

gcucagauuguucaaagcccccacccgggaucaggaccccgagauuccucuaaaagcucggaagguacacuucgcugagaaa

gucacaguccauuuccuugcugucugggcaggaccagcccaagcugcccgucgaggucccugggagcaguuugcacgagauc

gaagccgcuuugcucgacgcauugcccaggcagaggagaagcugggucccuaccuuaccccugauuccagggccagagcaug

ggcacgccuuagaaacccaucucuuccacaguccgagccucgcucuuccucugaggccacucccuugacccaagaugugacca

cacccucuccccuucccagugaaaccccuucgcccagccuguacuugggagggaggcggggcuaagccugaguaguuuccua

uuauuuauuuauuuauuuauuugaauaagaaauaaagccuuuuaauuuguagugau

73
AW048937
uuuuuuuuuuuuuuuuuaaucaucgagaaguauuuauugagcaccagcuuuggggucgg

gugugaggacucgggacaaugcagggugcugucccuucucgugagacgcuuacaaucuga

guggagacagggagggagccacaauacauguucuuggggugcgggcuaaggguagacagu

ccagaccaggauguuacagaaacagggauguuuggggcuggagucagacccacuaagugcu

uugacacccacgguauucaacacugagaaaggaucagccauugcucaguguccugugagc

ucccuuagcccccaagacaccaucuuggccuggcuccuuguacaacugcuacuaa

74
AV139913
cccaaaacccauucagcaaaguucccaaccucgacgggcuagcaguauuuaaccagugau

ggguucacuguuguauuuggugaauacuguauuuuguuucaguucuuucucccagauaa

uuugaaaacguuccaggagaaggcagcuuccuauaugcagcgugugcuuucuuauucuuu

uuuuuaauauaugacaguuauuugagaacccauuucuacuuugaauucauuuucguugaa

agugauguuucuucaccuaccauuuuccuauuaaaguucuguauucaaau

75
M32490
Sequence below.

agaccgugagcgagagcgccccagagaagcgccugcaaucucugcgccuccuccgccagcaccucgagagaaggacacccgcc

gccucggcccucgccucaccgcacuccgggcgcauuugaucccgcugcucgccggcuuguugguucugugucgccgcgcuc

gccccgguuccuccugcgcgccacaaugagcuccagcaccuucaggacgcucgcugucgccgucacccuucuccacuugacca

gacuggcgcucuccaccugccccgccgccugccacugcccucuggaggcacccaagugcgccccgggagucggguugguccg

ggacggcugcggcugcuguaaggucugcgcuaaacaacucaacgaggacugcagcaaaacucagcccugcgaccacaccaagg

gguuggaaugcaauuucggcgccagcuccaccgcucugaaagggaucugcagagcucagucagaaggcagacccugugaaua

uaacuccagaaucuaccaaaacggggaaagcuuccagcccaacuguaaacaccagugcacauguauugauggcgccgugggc

ugcauuccucuguguccccaagaacugucucuccccaaucugggcugucccaacccccggcuggugaaagucagcgggcagu

gcugugaagaguggguuugugaugaagacagcauuaaggacucccuggacgaccaggaugaccuccucggacucgaugccu

cggagguggaguuaacgagaaacaaugaguuaaucgcaauuggaaaaggcagcucacugaagaggcuuccugucuuuggcac

cgaaccgcgaguucuuuucaacccucugcacgcccauggccagaaaugcaucguucagaccacgucuuggucccagugcucc

aagagcugcggaacuggcaucuccacacgaguuaccaaugacaacccagagugccgccuggugaaagagacccggaucugug

aagugcguccuuguggacaaccaguguacagcagccuaaaaaagggcaagaaaugcagcaagaccaagaaauccccagaacca

gucagauuuacuuaugcaggaugcuccagugucaagaaauaccggcccaaauacugcggcuccugcguagauggccggugcu

gcacaccucugcagaccagaacugugaagaugcgguuccgaugcgaagauggagagauguuuuccaagaaugucaugaugau

ccaguccugcaaauguaacuacaacugcccgcaucccaacgaggcaucguuccgacuguacagccuauucaaugacauccaca

aguucagggacuaagugccuccaggguuccuagugugggcuggacagaggagaagcgcaagcaucauggagacgugggugg

gcggaggaugaauggugccuugcucauucuugaguagcauuaggguauuucaaaacugccaaggggcugauguggacggac

agcagcgcagccgcaguuggagaaugccaaggggcugauguggacggacagcagcgcagccgcaguuggagaagacuucgcu

ucauaguacuggagcgggcauuauugcuccauauuggagcauguuuacggaugacguucuguuuucuguuuguaaauuau

uugcuaaguguauuuuuuugcuccagacccccccccccuuucuugguucuacaauuguaauagagacaaaauaagauuagu

ugggccaagugaaagcccugcuuguccuuugacagaaguaaaugaaagcgccucucauuccuucccgagcggagggggacac

ucugugaguguccuuggggcagcuaccugcacucuaaaacugcaaacagaaaccagguguuuuaagauugaauguuuuuuu

auuuaucaaaguguagcuuuuggggagggaggggaaauguaauacuggaauaauuuguaaaugauuuuaauuuuauauca

gugaagagaauuuauuuauaaaauuaaucauuuaauaaagaaauauuuaccuaaa

76
AI121305
ccaauaccacagccgugaccacagccaagaccacagccaaaagccuggccauccgcacuc

ucggcagcccccuggcagugcccuccauauccugcuuguuuuucucauuaguaaacuccu

cuucuaaagaaaacuggggaagcagaucuccaaccuccaggucauccucccgagcucauu

ucaggccagugcuuaaacauacccgaaugaagguuuuauguccucaguccgcagcuccac

caccuuggaccacagaccugcaacacuagugcacuugagggauacaaaugcuugccugga

ucuuucagggcacaaauuccgcuucuuguaaauacuuaguccauccauccugcgugua

77
U35374
auggagaacgaguucacauacgaagauuaugagaccacugccaaguggcuucugcaacac

acugaauaucgaccucaaguggcagugaucugugguuccggcuuaggagggcugacugcu

cacuuaaaggaggcucagaucuuugacuacaaugagauacccaacuuuccccaaagcaca

gugcaaggucacgcaggccgacugguguuuggauugcugaauggcagaugcugugugaug

augcaaggccgguuccauauguaugaaggauacucacugucaaaggugacauucccagug

agaguuuuccaucuucuggguguggaaacuuugguggucaccaaugcugcuggaggacuc

aaccccaauuuugaaguuggagauauuaugcugauccgugaucacaucaaccuaccuggu

uucuguggccagaacccucuccggggccccaacgaugaaagguuuggaguucguuuuccu

gccaugucugaugcuuaugaccgggauaugaggcagaaggcuuucagugccuggaaacaa

augggggagcaacgaaagcuacaagaaggcaccuacgugauguuggcaggccccaacuuu

gagacuguggcagagagucgucugcuaaagaugcugggggcagaugcuguuggcaugagc

acagucccagaaguuaucgucgcaaggcacugugggcuccgugucuuugguuucucacuc

auuacgaacaagguugucauggauuaugagaacuuggagaaggccaaucacauggaaguu

cuggaugccgggaaagcagcugcacagacauuggaaagguuugucuccauucuuauggag

agcauuccacucccggaucguggcagcuga

78
X15643
Sequence below.

uuccaggacagcuggggcuccacgagagaaacccugccucccccccaaaaauggcccaaaguucacugacaaacucacauuug

ucugauauuuagcuauguaacagcacuuacgguagcaauagaauuugauucucacucaucacaaugaaaauggcuggcgcuc

ucucucucccucucuccccauuucaaaucugcaagcacaccccuuagagauggagagaauuugauccauuggagaaucgagc

uaaaaauaccaccauggaauugugggaaggauuaaaugcaauaaugcacaaaaggcacauagcagaaugugcccuaaauguca

gccauuguuaugguauuauguaaucuacaaaguauguuugcuuacuccgugugaaagacuuucagucuaucaaacauaaua

caugugaaaucaaaccuugaaaauuaauuuuuuucccaacagucaagacauuugccagcugcagagauuagcauuucaugaa

ucuuagucuugucugauuuuuuuaaugggaaggaacaacuauccucaacuauccuuuuuuuuuuucuguaguuuuaaaau

gaacuccacaaaacauguuuuuaauauagggaauuauaugaaauuguggggugggcagcgagguuaaaggcagaaauagccc

aaugguggcacauucacugacacagccuaaaagauuagcaaauuacccagccaacacauacaauuaauacaauuaauauuuuu

auaguuaaaacagaguuacuaaagaaauuguuugaaaagaaaauuaugaagacuggaaagacggcucagugcuuaagagcuu

uggcuagucuuccagagaaccagggucauccagcacucacaaggcagcuugugagcugauacuaucuguauauucaguccua

gggaaucugaugcuuuguccugaccuccaaaacaggcacaaauguggugcacaggcaaauguagagauaagacucccaugca

cagaacauaaauaacguaguuuaauuuuuuaaauuguaaaacugaaaaugguugcacuugcauuuuuauuuucagcacauc

cccagauauccgccauauaacaagaaaaugaugccacacucccaagaauuaagaauuacaccucccaacccuacccaaaugugu

auacucuaggucuaaagaaaugcaaaggaugaaguuacugccuugugcgguucucaaggagggaggaugccaaaaaaauauu

uuuucacaaagugugcugagaaacucuguagcuguuggagucaucuccugugcucuugccaaauaacugaaaggggauaca

cuggaugucugugaauggggugucacuuaugagugcuagaagcggguaccuggauguggacacggugucugagugguccg

cacuccaugucuccacaggagcgcuuauguguguuucuuuccuccugcuucuggguguuccuggguuuguuuacagccacc

ucucuguuggaccaggagacagcugucgucuccagaaugagcgggcacgggugugucucgguggcuguggcugugguucg

gcauaagucugagcauguccuggucgucagggugcguuugugcugugugugcguguccgggugagcuugcucuuucuguu

ccuaaaagaaaaugcacccugcgcuaccggcguccagagacucucagcccgcagaggugaccugaacggacagguagcaccuc

cagacagcgccugguuggcggguugcacagcagccccagauuucucucucuggugccccagcuaggguagcuggaagggag

cgguggccuggccuccggggagccgcugggccccgccgggcuaacccaggaggaggccggcuaggcugggaggguuagccc

uuggugcccuacgccugcccgggccagucgcggccgccggccauuggcccaaagaauuguugcacgucacuggcaauucccc

uagaagucugugcacauaacgggcagggcgcacugcaaggcugcuucucccgcauuuaggcugcggcugcaggcaccgcgag

cccggagcacccacgagcuuagugugcaggacgcaccccagcacagccaccuacggccgcugaaugaagcuuccaggaguccg

cccccggccgucgccccgucggaggugcacccgcugagagcgccuggaccgaaaggccggugcgcucaccugcuaaccugcc

agccauggggccacacgggaacgacagcgacuucuugcuggcacccaacggaagccgagcgccacaccacgacgucacucagg

aacgggacgaagcguggguugugggcauggccauccucaugucgguuaucguccuggccaucguguuuggcaacgugcugg

ucaucacagccauugccaaguucgagcgacuacaaaccgucaccaacuacuucauaaucuccuuggcgugugcugaucuagu

caugggccuagcgguggugccguuuggggccagucacaccucuaugaaaauguggaauuuuggcaacuucuggugcgaguu

cuggacuuccauugauguguugugcgucacagccagcaucgagacccugugcgugauugcaguggaucgcuauguugcuau

cacaucgcccuucaaguaccagagccugcugaccaagaauaaggcccgaguggucauccugaugguauggauuguaucuggc

cuuaccuccuuuuugccuauccagaugcacugguaccgugccacccacaagaaagcuaucgauuguuacaccgaggagacuu

gcugugacuucuucacgaaccaggccuacgccaucgcguccucgauugugucuuucuacgugccccugguggugauggucu

uugucuauucccgggucuuccagguggccaaaaggcagcugcagaagauagacaaaucugaaggaagauuccacgcccaaaa

ccucagccagguggagcaggaugggcggacgggccacggacuccgaagguccuccaaguucugcuugaaagagcacaaagcc

cucaagacuuuaggcaucaucaugggcacauucacccucugcuggcugcccuucuucauugucaauaucgugcacguuauca

gggacaaccucaucccuaaggaaguuuacauucuccuuaacugguugggcuacgucaacucugccuucaauccucuuaucua

cugucggaguccagauuucaggauugccuuucaagagcuucugugccuucgcaggucuuccuucgaaaccuaugggaacgg

cuacucuagcaauagcaacggcagaacggacuacacaggggagccaaacacuugucagcuggggcaggagagagaacaggaac

ugcugugugaggaucccccaggcauggaaggcuuugugaacugucaagguacugugccuagccuuagcguugacucccaag

gaaggaacuguaguacaaaugacucgccacuguaauacaggcuuucuacucucuaagaccccuccuugacaggacacuaacca

gacuauuuaacuugaguguaauaacuuuagaauaaaauuguauagagauuugcagaagggggggcacauccuucucgccuu

uuuuuaauuuuuauuuuauuuuuuagcugcaaacaagagagagaacuguauuugagugcuuauuguucuuguauaguuca

guuccucuuguauggaacuuaaagguuucugucugaagaguguugguucugaggacugagucugucugucugucugucug

ucugucugucuggaugauguuuucauguaucuaccucacuggucaaguauuaagaaugauauauauugcugcuggaaaucc

auaucuaaaggagagaguuuucuuccuguacccuuggacuugaaauauccugugucuuggaccuuucugcugugacaaugg

gcccuuucucucucacuccacuuauuuacucaaauggauucgaggcagggauuugagggacaacacuaguuguuuuguuuu

uguuuuuguuuuuuuguuuguuugguucguuuuugguuuguuguuguuuuuugggguuuguuuuuguuuuuguuuuu

uuggguuuuuuuuuuuugcugagaaaagucuaaaguuuacaguaaauaaauuguuuaaccaugacuucauugcacccguuu

cuucaaaaccucuugacucuggaguguccuugucucucccacuggaaaccacagguaaacuaugugucgugaccgaugagug

gcuuaauguguaagaguaccagaauggcaugcuugcaugcaccgugccuagcccuuccgugugugucuucagagcuccaga

ugcaaaccugugccuucccuaacuucacucgugucccaaagcaguccugccuguucacagcauaacccaguauguccuacag

uugcucuucugugcugucacuccagaaacccugacucacggaaacagaguuauggacauauguuuuuguccccauaugcuc

ugacaccaccuucagccuuacuugcuuaauaacuguguauauuuacaucacugcgucucuuacaguagugccuuuguacug

caucagggcuugguguguucaggaugaggaagauguucuguguaauagcuguucaagcaucuagaaauucugagggaaauc

aaaggccucggucagagagagagagagagagcaaagcuuuaaaaaacauagcuggugaaugcuucacgcccuucagccucuc

cucgcuccgucugcugucccgugucuucuguucccaauucucugcacuucuguguaaaccaggcuucccaugucuggcauu

ccgugcauuauaugauauuuggcggcacgucuguaccaguaaauucugguagcacccccuaguuacaauaauugcagacacu

cagcgcguacgacccccuaguuacauaugcagacacu

79
AI849109
uuuuuuuuuuuuuuuuuaagcguccaggcuguacuuuauuuuacacaagugguggcccc

agaaccacagggacaugaccuggagaguaggcacagugccugaggcugcaagagccaaaua

cagggauucaugccuucuccuugguccccaugaccaaauuaaaaaaaaaaaaaacaacaa

aucacacagcacacaucgccacacccauccccuccuuccuuucagcaacagccaauucag

cuuucuagccaaagacaguggcuacaacugaauuuacagagaaccaugcagccaagaaac

cagagccacggaggggagaggcuugcguugacuucccacaugugcugucccauagcagcu

gagugaccccacca

80
U70132
agaaagauaagggccagcaaggaaagaaugaggaugugggcgccgaggacccguccaaga

agaagcggcaacgccggcagaggacucauuucacuagccagcagcugcaggagcuggaag

ccacuuuccagagaaaccgcuacccagacauguccacucgcgaagaaaucgccgugugga

ccaaccuuacggaagcccgaguccggguuugguucaagaaucgccgggccaaauggagaa

agcgggaacgcaaccagcaggccgagcugugcaagaauggcuuugggccgcaguucaacg

ggcucaugcagcccuacgaugacauguaccccggcuauucguacaacaauugggcugcca

agggccucacgucagcgucucuguccaccaagagcuuccccuucuucaacuccaugaacg

ucaauccccuguccucucagaguauguuuuccccgcccaacuccaucucaucuaugagua

ugucguccagcauggugcccuccgcggugaccggcgucccgggcuccagccucaauagcc

ugaauaacuugaacaaccugagcagcccgucgcugaauuccgcggugcccacgcccgccu

guccuuacgcgccgccgacuccuccguacguuuauagggacacauguaacucgagccugg

ccagccugagacugaaagcaaagcagcacuccagcuucggcuacgccagcgugcagaacc

cggccuccaaccugagugcuugccaguaugcagucgaccggccggugugaaccgcgccca

gggcgcggggauccgaggacugucggagugggcaacucugccccagaaagacugagaauu

gugcuagaaguucgugcgcacuaugggaaggaagaggggggaaaaaagaucagaggaaaa

gaaaccacugaauucaaagagagagcgccuuugauuucaaaggaauguccccaagugucu

acgucuuucgcuaagaguauucccaacaguuggaggacgcguacgcccacaaauguuuga

cuggauaugacauuuuaacauuacuauaagcuuguuauuuuuuaaguuuagcauuguuaa

cauuaaaaugacugaaaggauguauauauaucgaaaugucaaauuaauuuuauaaaagca

guuguuaguacuaucacuacaguguuuuuaaaggcuaggcuuuaaaauaaagcauguuau

acagaaucaguuaggauuuuucgcuugcgagcaaaggaauguauauacuaaaugccacac

uguauguuucuaacauauuauuauu

81
M13805
cugagaggccaggugggcggcgaaaucaacguggagauggaugccgcucccgguguggac

cugagccgcauccugucagagaugcgugaucaguacgagaagauggcggagaagaaccgc

aaggaugccgaagacugguucuucagcaagaccgaggagcugaaccgcgagguggccacc

aacagcgagcuggugcagagcggcaagagcgagaucuccgagcucaggcgcaccaugcag

gcccuggagauugagcugcagucccagcucagcaugaaagcaucucuggagggcagccug

gcagagacagagaaccgcuacugcgugcagcugucucagauccaggggcugaucggcagu

guggaggagcagcuggcucagcugcgcugcgagauggagcagcagaaccaggaguacaag

auccugcuggaugugaagacaaggcuggagcaggagaucgccaccuaccgccgucugcug

gagggagaggaugcccaccugacucaguacaagccaaaagaaccugugaccacccgccag

gugcgcaccauuguggaagaaguucaggauggcaaggucaucucaucccgggaacaggug

caccagaccacccguuaaggacucagcuccuuccgcccaguuccccgaggcugcagagag

gcagcuucccucuccgcuccggcaucacccuccugcuacagccucuccccagcauuccua

ugcuugagaccauuaaagcuugcugaccugaagugaacuguggccuuuguucugaacacu

gaaauaaaugaccauggugac

82
AV138783
ccccaggggugaaaugaggauuccccacccugcggaacagugaaauguguauaauuaag

aggagggcgacgacccuugccgcgggacccgggacucgagcccgggacuucgcagcuaca

gcaaaucuauuuuuaauauugugcugagcaagacagaucgcuugcauauuuuuaaaaauu

uuuacuacagagacauuccaauaaauucguuaagcc

83
K02927
Sequence below.

cugacagucgucucugucccuucuucgccucggagcugcuaacuggucucgaaccucucagcacuucagcuucuagcggcga

ugcaugugaucaagcgagauggccgccaagagcgaguuauguuugacaaaauuacaucacgaauccagaaacucuguuaugg

acucaacauggacuuuguugauccugcugcagaucaccaugaaaguaauccaaggccuauaguggggucaccacaguggaa

cuggacacccuggcugcugagacagccgcgaccuugaccacgaagcacccugacuaugccauccuggcagcaaggauagccg

ucucuaacuugcacaaagaaacaaagaaaguguucagugaugugauggaggaucucuacaacuacauaaauccgcacaacgg

cagacacucucccaugguggccagcucaacacucgacauuguuauggccaauaaggaucgccugaauucugccauuaucuau

gaccgagauuucucuuauaacuacuuuggcuuuaagacacuggaacggucauauuuguugaagaucaaugguaaaguggcu

gaaagaccacagcauauguugaugaggguuucuguggggauucacaaagaagauauugaugcugcaauugaaaccuacaacc

uacuuucugagaagugguucacucaugccccuccuacucucuucaaugcugggaccaaccgcccacagcugucuagcuguuu

ccucuugaguaugaaagaugacagcauugaaggaauuuaugauacucugaagcagugugccuugauuucuaaguccgcugg

gggaauugguguugcugugaguuguauucgggccacugguagcuacaucgcugggacuaauggcaauucuaauggccuug

ugccaaugcugagaguauauaacaacacagcucgcuauguggaucaagguggaaacaagcgcccaggcgcguuugcuauuua

ccuggagccuuggcacuuagacaucuuugaguuccuugacuugaagaagaacacaggcaaggaagaacagcgagcacgcgau

cucuucuuugcacuuuggaucccagaucucuucaugaagcgaguggagacuaaccaggacuggucauugaugugucccaau

gaguguccuggucuggacgaggucuggggagaggaguuugagaaguuauaugaaaguuacgagaagcagggucguguccga

aaaguuguaaaagcucagcagcuuugguaugccaucauugagucccagacggagaccgguaccccauacaugcucuacaaag

auuccuguaaccggaagagcaaccagcagaaccugggaaccaucaaaugcagcaaccuguguacagaaauaguagaguacacc

aguaaagaugagguugcaguuuguaacuuggcuucucuggcucugaauauguaugucacaccggaacauacguaugacuuu

gagaaacuggcagaagucacuaaagucauuguccgaaaucugaauaaaauaauugauauaaacuacuacccuauuccagagg

cacacuuaucaaacaaacgccaucggcccauuggaauugggguacaagguuuagcagaugcuuucauccugaugagauaccc

cuuugagagcccagaagcccaguuauuaaauaagcagaucuuugaaaccauuuacuauggagcccuggaagccagcugugaa

cuagccaaggaguauggccccuaugaaacguaugagggaucuccagucagcaaggguauucuucaguaugacauguggaau

guugcuccuacagaccugugggacuggaagccucucaaggagaagauugcaaaguaugguauaaggaacaguuuacuuauu

gccccaaugccuacugcuucaacugcccagauucuggggaauaaugaguccauugagccuuauaccaguaacaucuacacuc

gaagagucuugucaggggaauuucagauugugaauccucacuuacugaaagaucuuacugagcggggcuuguggaaugaga

gaugaaaaaucagauuauugcaugcaauggcuccauucagagcauaccagaaauuccugaugaccugaagcaacucuauaag

accgugugggaaaucucucagaagacuguucucaagauggcagccgagagaggugcuuucaucgaucagagccagucuuuaa

acauccauauugcugagcccaacuauggcaaacucacuaguaugcacuucuacgguuggaagcaggguuuaaagacuggaau

guauuacuuaaggacgaggccugccgcuaauccaauccaguucacucugaacaaggaaaaacugaaagauaaggaaaaggcac

ugaaggaggaggaggagaaggagaggaacacagcagccauggugugcucuuuggagaacagagaggagugccugaugugug

gauccugagaaaagcggggccugggagacgcagcgggcucuccugcccgagaggcagacgauuugagcauagauaggauagu

ggguuugcuugguuaucagcagcucugcuuggacgugccugccaggacagggagccacgacuuacaguacuguuucuacac

aguguaaauaucauuuuuaacaaacagaaaaccaaagccagcuuugauauuaggaaucaagguagaggcuuugggaauacua

aagagccuuccugcaaauagugaggagacuuaggaagucucgucucuccagcuuucccugccuggccauucucaguuuggg

caaagagauuuaguuugauuugacugauugccuagaaguaaaaucaagcaauuacucaucagcuaaagaccuuugucuagac

aaacuucuauaagucauuuugaaauaaacauuucuaagugau

84
X07699
Sequence below.

uugccucagacgcuagcuguagcuggcaggcgguuguacgugcuccagagucgucgguacccgcuacugcagucgcuuucg

uguggcuuccgcugagcucuuccgagcugcucgcucuccacacgcgccgccgccguaauccgccaccauggugaagcucgca

aagguaagaggccuuggcgcgccgacgcggacgacuaggccccugcuuucggagggacgcgcgcgcgcccgcccguccgucg

cggaggggaggagggcuugcgcgcaaucccgggcgcguucgagggcgccaugcugggggggaaagucucgcgcgacuagcg

ggaggucucgcggugcuugcccucugacuuagggggaugagaagagcggaggcagguuuccgggagggcgauaucgaggg

uucggauguagcgggcgggaggggacggugugaggagagaucggaggagcugagagcggauaggggcacggcgugggaaga

gagggccaaccuuaggcggcgagcggucccggggccccgccuccccgcgcacgugcucuggugcgcgcccgccacgugcucu

gcggagccccgcacgugucgcgcgacccggggcagugggggagugucuguaguaccccggaaagggggacggcagcguggg

gauggauggguggcccggcgaucugcugucucugccggugaccgggauggacacgugguggaccccugagguggcggcgu

ggugacuccacgugguggggcuggaagcgagagaaagugggaagcaguuggguuacguggugcugcuuuaagaggugauu

ucgagauacccccuuccccagcaaauaacuuaaagggaucccuuuaacuggguuuuuuuuuuuuuuuuuuuuuuuuuuuu

uguggaagaugccagaaaauagauggccaggauuaggagacuuuauaaccuguggcuguuucuugguguagaguucuguc

ugcucaguuaucugugagaaggaaaaaaaaauuaugcgcgguucgcagaaaaaacugccaggagaaugccaugccuggccaa

gaagaagucuuuaugcuuguguccuuuaguaagaaaaaggugguggccaaaggcaaagugacugaaaaugcgugcaauuuu

ugugugcguuuguaggcuggcaaaacccacggugaggccaagaaaauggcuccuccuccaaaggagguggaagaggauagu

gaagaugaagaaaugucagaagaugaagaugacagcaguggagaagaggagguaagaagcuauuugcagcgaauuaaaccgg

uggaauugaaugucuggaagucuuagaaauacaggauauguaguaaaugguugaauggcaagccccuuccucccucccuccc

ucccucccucccucccucccucccucccuuccuuccuuccuuccuuccuuccuuccuuccuucugcaagacagucggcaaaac

aggggacagaaacaggcagaauuuugaguuccaggcaagcagggaguaguacauagugaaaccuugucucaagaccguuguu

auggucaugcucaaucagauuucuuagaaaagcucaggugcugaguccaguuuuuuuuuuuuuaaaguauugaaagccaug

ucuccuuauuucaggguuuaauguuuaucuuugugugugcgcgcacccauuaagcaugcuugguacccucauacuagaaug

uacuuggauccccuggaacuggaguuaaagccacaugugaauguuacauguuacaagaguaacacaugugcuuaacuuuug

agucaucucuccaguucuugguuguuuguuuuuuuuuuuuuaagccuaucuaauguccauuuucuugugcucaaaguuag

ucucuuaauguagcauuggguauaaaggaaugcuuaugauuuguuugcuuucaagguugucaucccucagaaaaaaggcaa

aaaggcuaccacaaccccagcaaagaaggugguuguuucacaaacaaaaaaggcugcaguucccacaccagcuaagaaagcag

cugugaccccaggcaaaaaggcaguagccacaccagcuaagaaaaacauuacaccagccaaagucauuccaacaccggguaaga

agggagcugcacaagcaaaagcguugguaccaacuccugguaaaaagggagcugccacuccagcuaagggggcuaagaacgg

uaagaaugccaagaaggaagacagugaugaggaugaagaugaagaggaugaagaugauagcgaugaggaugaagaugaugag

gaagaggaugaguuugagccaccaauaguaaaaggagugaagccagcaaaagcagcuccugcugcuccugccucagaggaug

aggaagaugaugaggaugaagaugaugaggaagaugaugaugaagaggaggaagauggugaguuagaucuuaggauauuua

ggguacugcauguacauucccucacuguuucauuagauuaaaaacucauuuugugcucuuaguucuuuccauaacuuaaua

gguuuucauuugcuaaguaguuuuuguuuuuuuuaaguauuuguagcauuuaucuugucuggauugguagguagcaaau

acauuugccugauuugccaucuuucuuccagacucugaggaagaaguuauggagaucacaacagccaaaggaaagaaaacuc

cugcaaaaguuguuccuaugaaagccaagaguguggcugaggaggaggaugaugaggaagaggaugaagaugacgaggaug

aggaugaugaggaagaggaugacgaagaugaugaugaggaagaagaggaggaagguaaccauauuaacuuuuaaaguaugc

ugaccuaaguaaggcuuacuggcuaugcuaaagugucugcuuacucaugaauggcauuuuaaaacaucuagaaccuguuaaa

gcagcaccuggaaaacggaagaaggagaugaccaagcagaaagaagccccugaagccaagaaacagaaaguagaagguaagcc

ugcaaaacuggggaaacagaucagaguagcacuagcacaagugaugagugacaaagggacuuaauacugaaccaugggguug

aaaugaaauaugcugaugugcuuuauaguuuaugaugaaauuuguugugugcuuaagugggcugaaaguucauuuuuugu

gugugcaggcucagaaccaacuacaccuuucaaucuguucauuggaaaccuuaauccaaacaagucuguuaaugaauuaaaa

uuugccaucagugaacuuuuugcuaaaaaugaucuugcuguuguggaugucagaacugguacaaauagguaaguuuuaauu

gaauguuacauguguaucagcuagaauuuuuaguuuccaguuguauucuucccugccuuuaaacauggggcuauaucuaac

uauguuaguaaaagucaguugucuccucucguggccuuaaguacaguuaaggagcugcaguaagaaagacuauaguauuga

acuaaaugaucgagucauagggccugcaauuugaaguuccuguguuugacuugauaaagauaaaauaaaauuuaaagaagaa

aagauauuaaacacauaaaauuuugugcaguaucuacaacuauggaucugcauagucauaugcuuuuagcuaaaaguauucu

cuguacuuuuagcgggguccaugcuagcuacugcuguuaguuacaauauacugaaugaagaaaucgaggugaauuuguugu

aaugucuugguacauggacuuguuuuguuuuuuguuuuuuuuucuuuaagauuuguuuauguauaugagcacacuguag

cuguccagaugguuuugagccuucaugugguuguugggaauugaauuuuuaggaucucagcucgcucugcucucaguccu

ugcuugcucuggcccaaagauuuauuuguuguuauacauaaguacacuguagcugacuuaagaugcaucagaagagggcau

uaggucucauuaugggugguggugagccaccaugugguugcugggauuugaacucaggaccuucagaagagcagucaaugu

gcuuacccgcugagccaucucuccagccuuuggacuugguuuuauggaagauaagggugaucuaguuuuauuuuuguuag

ugcuguagaugcucugugugugugccacaugguauaagugcagaucaccuucucauaccuguaaucuuguuuuuuccaucu

ucaaggaaauuugguuauguggacuuugagucugcugaagaccuagaaaaggccuuggagcucacugguuuaaaaguguuu

ggcaaugaaauuaaacuagaaaaaccaaaaggaagagauaguaagaaagguauguaagggggucugggugacuggauacuaa

cagacuuaggcagucuggugccucuuccuuaguuucauccucauugugaaccaaugagaugucauaggucaugugcuuguu

gacagguuugauuccugggauauauaaugucagggcugacaggaggaauagcuuagugaguaaagaugcuugcugcaaaau

guuugaucucuagaagccacaugaagagagaagaaccuuuaaucccagcauuugggagacagaggcaggcagauuucagagu

ucgaggccagccuggucuacagagugaguuccaggacauccagggcuacacagagaaacccugucucggaaaaaaaguuuua

gcuuauccucugaccacauguguaucgugacaugcuugaagcuuaccuaucucuuaaaugaauucuugaucccuauauuuu

gaguuucagaauuuggauuuuaaguguuuguuucuuaguugugcugaaaauugaacgugggcuuuucacaugcuaggcaa

auuuguuggguuuuuuuguuuguuuuuuucucaagacaggguuuuucuguguagcccuggcuguccuggagaccaagcua

gccuugaacucagaaaucugccugccucccaagugcugggauuaaaggcgugagucaccacugcccugcuaggcaaucacuc

uuaaaacugcuacauauccucuguccccuuuugcucauuuuacaagguugcugugugcucaaucugcagucuauguuauau

gcuuacuggaucuaggcuuuugauguagaaugaaccauaugagugaugagguaucuuagagauggaaacuaagucuaaaua

gacuuguuccauauacaacuuaauacauauggucuaaggaacaugauauacauguaaacaaguaggaaggagauaagucugg

uguccagggaagccaggagagccucaucugaaacuggacagggguuugugagucaucaggugacaauugaacauaggguacu

cuucaugcaaaugguuaguaaccauugagccaccucuccaucccuuuauaccauuuuuuuuuuuagcauauauccuuguac

uuuauaggaauuauuugcuuuauucucuugugacuuguaaauugauguacuuaauuaaaucuuuuuccaacauaguucga

gcugcaagaacacuucuagccaaaaaccucucuuucaacaucacugaggaugaauuaaaggaaguguuugaagacgccaugg

agaucagauuagucagccaggaugggaaaaguaaaggguaguuuugugucuuugaguguuaaaguuuuauuaaguuuagu

gucuucuuccccucuccuuguccuugacagucucuagucugcugcuucaaacuuaacuucauaaccagaaaauugaauaucu

gguccucuggccucuaccucccaaguucugacauuaaaaaugcucaacugauggguuuugaaggugugaucaauuuuacag

gcucaauccaaauuggcaucuuuugccacaaguacuauccuucccuauuuuaugagagaaaugugauucuaggcaguucag

ucuauuguguuggcucuuuuuccuccucaccaguuuaaaggaugaagaugagcuaauacauaguaaaagaacaguaaaagca

caugugacuaaguccuucaugucugaugcuugaguaauauuuucucuaacguaguaacugaauugucuuguacucuuucag

gauugcuuauauugaauuuaagucugaagcugaugcagagaaaaauuuggaagaaaagcagggggcagaaauugauggacg

aucuguuucacucuacuauacuggagagaaaggucaaaggcaagagagaacuggaaagaccagcacuuggagugguaaguua

aaggguuuauuguguagugggaacaggaaucauuuguaucuuuguauuuuaaguaauugguuaccuacaauuaguucacc

uuuguucauauagcugauguuuagucuucaugagugaaagcuauuugaaaucauuuccuuuggaguauaguaggcaaauaa

agcuuuuuguuggguauguuuuguacuuuaaauggcuuaaacuauuuuagaaaauaguguaagacaacaaagaacaguuau

cuaauuagaaugaaaaugaaaggagcaaagaaggcauuacuguauauaauggauauacacuggugguucuagaauuauggu

auaugguacaugguugaagugccauuguuucaguuaacauuccaguaaccuuguggauuagguuggagacaugcuuuauag

gugacccacuuacugaguguuuaaauauacacagacauacucuaacauaccuugcuaauguguuaucuuuguauuugcagg

ugaaucaaagacuuugguuuuaaguaaccuuuccuacagugcaacaaaagaaacucuugaggaaguauuugagaaagcaacu

uuuaucaaagugccccagaacccacauggcaaaccuaaaggguaaaauaauuuuuacguuagaugugggcuggacauacaua

cucuuacguauaagaguaagacuguccuguuagcuuaaaaaaaaacuaaaguuuuagcuauacaaagggcaguaaauauuga

uaguaaauuacaugcugaugccaaguguuucuaagcuuuauucugagaacugacuuucaaccuucagguaugcauuuauag

aauuugcuucauuugaagaugcuaaagaagcuuuaaauuccuguaauaaaauggaaauugagggcagaacaaucaggcugga

guugcaaggauccaauucgagaagucguaaguccuuugacaugauaugacuugguugggugauuuuuuuuuuuauuuuua

ugugccuauaugcucauuuggggcugucuuuauguuguugcugagaaaaugacaacuggauaugaugacugauuaccuga

gaaauaauugaugaaaucucaagaaaauuccucuagauagucaaguucugauccagcuaugucaacucaaagcagcaaccuu

gauugcccucugaguacgcuuuuuuuuugauccaguguagucuuuuuuuuuuuaaccuuaauuucuuguguuaauugcuu

uuucugguaaaagggggaaaaaaagacauaacaaaaucaguguaagggaaggcucagugguugagcacugagaggaccuggg

uucaaaucccagcacucacauggcaccuaucgagacaggauuucucuguguaguccugccugucguggaacucacucuguag

accaggcuggccucaaacucagaaaucugccugccucugccuccuaggugcugggauuaaaggugugcgccaccacugccca

acccugucuguaacucuuaagaucugacauagauugcagacaaaacacuaaugcacauaaaaaaauuuuuuuuuuuaaaaaa

ggaaucuacuucagcugaauguggcaguauggcaguauucaccaaggguucauagugaaacaggaauuuuucucuuccaga

accauccaaaacucuguuugucaaaggucugucugaggauaccacugaagagaccuuaaaagaaucauuugagggcucuguu

cgugcaagaauagucacugaucgggaaacugguucuuccaaaggguaagaaggcguaguaguguugcugcuuuuuagugaa

uucugcauggagaacuugggucugcaguaucuucucauugagcuccuuucuguccaucagugauagauuauggauucgcac

gagaagaagagagaauucacagaacuggcacuuaucuucuguuuuugcagaaguauauuuggcuguugugugagacauuau

gagauacuggcgauuuucucgaccugaagaguacuuuggucacucuacuugggugacuugguacuuauuguguuacuuua

aaauguguuuacuuaaugggugagguuuuuuuguuuuucuuuucuguuuuagguuugguuuuguagacuuuaauaguga

ggaagaugccaaagcugccaaggaggccauggaagauggagaaauugacggaaacaaaguuaccuuggacugggccaaaccu

aagggugaagguggcuuugguggucgagguggaggcagaggagguuucggaggcagagguggaggcagagguggaagagg

uggauuuggaggaagaggccggggaggcuuuggagguaaggaagggaaaggaacuggaaacggauuccuaaaccugugucc

uaaccaaccaccuuaaaugggaaggucaguccuaauuguaucacccuuugauguuuuuccuuccuauagguagaggaggcu

uccgaggcggcagaggaggagggggagacuucaagccacaaggaaagaagacgaaguuugaauag

85
X57800
Sequence below.

uuagacgguugcgcgcgcagaggguugguaguugucgcuguaggccuucgcugccgcuucugcaucgugaaucgggggac

cuuggcagccagaccucguuccucuuagaguagcucucaucuagucgccacaacuccgccaccauguuugaggcacgccuga

uccagggcuccauccugaagaaggugcuggaggcucucaaagaccucaucaaugaggccugcugggacgucagcucgggcgg

cgugaaccugcagagcauggacucgucucacgucuccuugguacagcuuacucugcgcuccgaaggcuucgacacauaccgc

ugcgaccgcaaccuagccaugggcgugaaccucaccaggugagcggguggcgggagcggggccccacucuucccgcuuccgc

ucuuggcggggcugugacucugcacgcucauuggcuggcuuggccauccgcgcuuucugauuggucuauggugucggggg

cagcccucaccaaagcgcgcgguuccgaaaagcccgcgcuggcaguggcgcccacucuguuuccgcgccaaagccacaaagcg

ggaguccgcgggaaaaugagugcuccggagcugugcucauuaaaugccugcagcuuugaguggcuggucuuagcgccuaau

aaacgagucuuagugcaaauguaaugucgacuuagagugacaauagaccuuuucuugacuuccagagucucacugcgcauca

uggauuugaggggaaaucugucaguuuuagcuuuuaacuuugcuacagcuaccuagguuagugccuccuguauacguguu

caaggacagugugugacuuauuuuaguacagauacauggauuagugccacuuguauacauuuugaaagauuuacgaaaagg

ccagacgugauggggcacauucuccaguacacuagaaaccaaggacaccccgcucaaaaagaugcuuucucgaauguuggcu

uuuagugcauuuuacuaagucgguuuuaagaaucacauauacccgguaauuugcuucaccccugagagaguuugggguacc

cuuagccccuuuaacaguucuccaaccgugagugugaaaugguacaacuuguaauugcuuuuuaaaauauagauguggauu

acauguugauaaagccugucuuuuuuuuuuugggggguagcauguccaaaauucuaaaaugugcugguaaugaagacauca

uuacauuaagggcugaagauaaugcagacaccuuagcacuaguauucgaagcaccaaguaaguuaaacaccuuuaaaacucg

gaguuacguguuguuucuguuucucaaaaccaaaaaaaauauuaacaauauuguaaauuccaucauagauaggaccgugug

gugugcuugguaacauuuuccuucuuuugguagaucaagagaaaguuucagacuaugaaaugaaguuaauggacuuagaug

uggagcaacuuggaaucccagugaguuaccuuguuucugauuguguguuacccugcugugauaccagcugaugcguguuc

ugaguggaguggugguauuggggaugaauggcacacugccauuucacuaaaccacagcagucuaaaguugauugaguuuua

aagaaaccagaagucuugcauucugaguucugguuaagaugcuaaaucuugagaacaugaagcugagccuucccccuuuucu

agacugaccuuuaacuuguggguuuacaggaacaggaguacagcuguguaauaaagaugccgucgggugaauuugcacgua

uaugccgagaccuuagccacauuggagaugcuguugugauauccugugcaaagaauggggugaaguuuucugcaaguggag

agcuuggcaaugggaacauuaaguugucacaaacaaguaauguggauaaagaagaggaggcggugaguaguaagggggcgu

ccaguuaggugucugaagcagggauggagccucggcuuuuguuuuuauuuauucauucauuuugagauggagucuugagu

agaccaagcuaucuuagagcucagagacgacuccauaagcuuuuacagguagcauuuggaaagcuaaguguacagccuuuug

cuuccuggaaauacucuuggcaaauaagugaggguuggcaagugagcaaaagaaaaugguuggggguguauguagcuuuau

guguugcagguucaagaguauuugcagucccaagggaaauaagaaagacuucacaaaauguggaaagaguuguauuaaaugc

ucuugacaguuacauccauagagaaagcugggcaugaugucucaaacccacaacugauguacucaaagcuacagcaggaaga

uucucagcuuaaagucaaccuggcagaaaaucuagcucaaaaagaaugaggaagaaauugggaaggcaaaggaagauguucu

ccgaguccuccucauucaaguagaacauacuaggccucuuuaauuucuaaguaucccugaaucgaggcuuuuucucaggaau

ccaauguauauuucauggcuacacuuuuuuuuuucuuuuuuaaguuuugcuagcuagccugagcaucagaauuacacacag

aagucugaacuaaauaggauuuuuaggguuuaguauagugaaauucagagugcuucugcaaguauuuaagguaaauauaag

guguuacuuggccucugcaugaauuuaaaguaaaugaaaguguaagaauucgaacauagauaaacacacaacccaagaacua

guucuuaaccuuaaucugcugaauuauuucuacuuccauaucaacuucagcuccucaguucucaaauacugacauguaauuc

aucaguauuugucugaugugcaagcauuuccacaacaaaagaaauuaaggaauuuuucaguauccacauguucaaggauugg

gaauugaauaaaauugauaaucauacaaugaagacugguuuacugucccuuagcuugcauucagcuguugguucuuguuuu

uggaagugguuauguguuaucuuccucucuucaugcauucuuugcaagagaaguauguacaaucugaauaggaacaacuuu

cuccuuuguuuugauugcuugggguguggcucuacaggaugggcaagcuagacuuuuuucuucuuuagucaagguuuuca

ucaacccuuccaaaaugauaacuauuuguuuugcuuugugguauaauaccgugaucuaauagugugaguuucugaugucua

cagugagccuguuuucuccucuagguaaccauagagaugaaugagccuguucaccuaacguuugcucugagguaccugaac

uuuuucacaaaagccacuccacugucuccuacaguaacacucaguaugucugcagaugugccccuugguaagaugauaaguu

ugaacauuguuuuguaaugugguauuuauaguauucggugguuuaauuuuuccugucuuucaguuguagaguauaaaauu

gcugacaugggacacuuaaaguauuauuuggcucccaagauugaagaugaggaagcaucuuaggcauugcuagaaauugag

aaaacuaaaccuuugaagauugcuccugagaugccagcguguccugaggucuuuucugucaccaaguuuguaccugaguau

ucuuaaauauuaaaauaaaauauguagauaucuucuguaaauaaccuacuuucuuuucucuccauucuccauaauuugcuu

aaagaauaagcuccaaaguaaaaacuaguuuuguuaacaugaauguuucugcuuuacaaauacuggugauuuuccaucaaug

aucuugacgcuaaaugcaguuuuaagaaauauuguucaauuuaaauaaaguuaacaauuugaaaaguca

86
M35247
Sequence below.

ggugcaggauguaggccugcagaauugucagacccaguggcggcuuuugccacuggaagaauuuccaacauaaaacaga

ugaucaguuugggacaaucgauucugcgaccagagguagugucauuugguuacuuuuaaaauucagauugucuggugu

uuuccaaucacucgcgacuguaauuugaaguuggguucugagauaauacaaucgcugucgcucuaguuuauaaagcugu

ccaagaucugcccagucccagauguccuggguccucagggccgcuguggucugccaacuucugcagcuggaugccagacc

auccuggacucggaucccuuuggguauuucuacaccgcugugucccggccuggccuuggggagcccugguucauaaucg

ucggcuauguggacgacaugcagguccugcgcuucagcagcaaggaggagacuccgaggauggcacccuggcuggagca

ggaggaagcaggugacugggagcagcagacucguauagucacaauucaaggacagcugucugaaaggaaucugaugaccc

ugguucauuuuuacaacaagagcauggacgacucucacacacuacaguggcugcaaggcugcgauguggagccagaucg

gcaccugugucucugguacaaccagcucgccuaugauagcgaggaucuccccacccugaacgaaaacccaaguuccugua

cagugggaaacagcacuguaccucacaucucucaggaccugaagagccacugcucagaucugcugcagaaauaccuggaa

aaagggaaggagaggcugcugcguucagacccuccaaaggcacaugugacccgucaccccagaccugaaggugaugucac

ccugagguguugggcccugggcuucuacccugcugacaucacccugaccuggcaguugaauggggaggagcugacccag

gacauggagcuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugugguggugccucuuggga

aagagcagaguuacacaugccauguguaccaugaggggcugccugagccccucauccugagaugggagccugcauggua

ccaaaagccuuggauuuggauuguugccaugguuuucauuuuguucaucauuugucucugugugguuugcauaugcau

gaagaagaaugcaggugggagaggaaggcgugacacccaagaagcaggcagagacaguccccaagacucuagcaagacug

uuguggaugaugaggagauggggguuugcuuuuggaagauuaaguccuguaaaacuugucuaggccacuccccaggaac

uucaguuggcgagucuuuacugucaccuugacuggauuuaggaucaucugggagaugccccuuugaguggcugggcug

ugaggacagcaggccaguucuugccacccuggacagaaacacaucucaccuuucuggcucaaggaucugaacaccugucu

cuugccuacucggcuucuagucaggcauuuugucaccuugucaagggucccagggacacaaagcucccuccucucaccca

cagcacucuggguccuacccucagugcuucagggacauuuaaucaggucaaauugggaucaauggcuuugaugcagaaa

agaacuguggacuaauagagauaggguuuaauuaaaaaauauaucuuuuuaauuuu

87
AI553024
cuggcacggacauggcugucuucugucugcugugugggaaacgcuuucaggcacaaagcg

cacuccagcagcacauggagguccacgcaggcgugcgcagcuauauuugcagugagugca

accgcaccuuccccagccacacggcucucaagcgccaccuucgcucacauacagguuuuu

uucuccaugugucaccaagugaaguuugugccuucuauagcaaagagaauauuuuuuaca

uccuacuaacaguagauuuuuuuguagugaacauuuuuuguauuuuuauuuauaagucuc

auaagaaaaauagcgauguucaguuguauaccuugaaucugcaguuagaagagaauaaag

uuaacuc

88
X16995
Sequence below.

ggagccccagugcaggaggcugcgaaaguugggggagugugcuagaaggacugcggagcggagcgcacgcgggaccaggcu

gcgacugggucgcuggucccggccacagggagugggagccggcuggguagguaccccgcagggagcguguuucuguuucua

gggacagugcaugaaagagaugggguguacgcgcgggcgaaaaggaaggguguuuucgggucggcuuacgaggaggggug

uguagggugcauuuuugguauuaaaggauagcucuuggaguagggugagccagggcuugaaguuuaggaagcgggcgaag

ggucugcaaggugcuugguuuugguagguagugggcgcuuguuuaggagguuuccccgcuaggaucuccagugugaggca

cucuguacucuggguuuggguguugauugccggguaggggguugucugagcauggacugggaaaagguacucagagcuuc

ggcguugcuggggauccauccaaguacaaguaagauuggauuuccacgggucuccuucccggcucucagcccccuuucccag

uguuuacuuaauacuucauaggcuguacuuagauuuucugauucccuuaccgaacuuucuuucugaaccgugcuggaagac

cuggggguugcugaaggaaauggccagcuagguuggcuggguaaugguuguguuagacuaaguugucagaguaucuagaa

accuaggagcuguagccuggugcagcuacugaaagccgcacguggagccuggguggaaguugcucacgauagagucucgau

guaguacugacuaggggggagaccccuucugucaucagacagacuuguauaccccaguggucuuuugaaucuguuagguag

ggugcagccugcgggcuuggucaccuaacagguguugccaggaccugccccaagccggauucucccacucccucuuucaacc

ccgccucuuccuccuccuugagacacccccacccccucaggaggcuagaugcagaucuguaucuuguguugcugacuaucgg

ccugaagcuggguagauugguggggguugauccggauguaggauguccaaguggagaaacaggauuugaauggagcuggaa

caaacgcccaguccugacugcugccacccuucuuccuccacccccaacccaucccuucccaggcuucuugcaaacagaggcag

aaguggccauauuucuuucuuucucccaggugcuguaugcccuagggacuugacacggggcaggcggggugggaacugguu

ggggggggacgugcuguuuuaugggaagucguaugccuagccagcgguggagcuguccuggcuaggcacccagggguggu

guggggaaugggagaaauacugggacuagagggucucaagggccagcagguggugauagucuuuuucuccaccccacccuc

ugcuccaccaccccucugccucagcaccccucugcccucagcaccccucugccucagcacccucugccuccagccacccucug

ccucagcacccucugccucagcacccucugccucagcacccucugccucagcacccucugccucaguguuccugugugaccu

gucuuuucaacuagaaagucuagaacuguacagaccccagaguuggagguggaaagggacacuagguccuggagccuccucu

gugggcuuuuuugaccagaugagaacguaagggccuccuccagcuaucccuggucauucaggugcuucagguuugugaccu

uugcugagacccuggaugcugcagcaaacagacaucugcuuuagcagagggacagcuugucucugugcauccgcugguagg

auccuccacucuguccaauuagcuugcgcugcugcuggguucugaguguucucuuacaaaaugacaagguuagggggcugg

agagauggcucaggggcuaagagcacccauguggcaguuugcaacugucuguaacuccuguuccaggggggaucugacacc

cucacacggacaaacaugcaggcaaaacaccuauuggcauggaaaaugaaaauaaaugaccggguuagcugagaaauuccuuu

ugagaguugucuuuucuccaguccaggacugcucucuggaucuuccugcucaguuccucgccucccuuccauauaugguau

uuaagguuuuacuuuuuuuugcguuuucaauuguuuuuaauuguauuuauaugugucucugugugugcacaugagcaug

gguguccuacaaggcuagagacaucagauguccuggagcuagaguuacagaugguugugagccaccugauguaguugcugg

gaacuggauuuaguuccuguggaagagcagugcaugcucuuaaccacugagcaacuucuccacgcggcccccccccaguaua

cgguauuuaaaacucuauagcaaugcuacccaacccauuguggagcuggggauggugagguggccuaguuccccccaacucc

uggaaacaugucagaaaguacagagugggugccugugggaucagcaugcgggggguggugguggugagguguggggcugc

uuucucccgaggcuaccgugauagacaguuguaccuugcuggcagccucuaccccauuuccaggaugucagucucugcagac

guaugggggacgguggggaagggguauacagagccaugggugugccugggaauguacucccaggaagugacugguugaaaa

gucagcagaucuccugggggauagaggggugggcugaagcucuguggguugccucucucagcccugaccugugaacaggga

ggcuggggguuggaggaacacagcuucccccuguuccuggggggacaugcuggacagccuuuccuagcucccccggcccac

ugggguguggcuggucgucggacugagcucuuuuggaccuggucucugccugugagcuuugugacucguugagauagcau

uugggcugagggauugggagucuucuguucuuugguccugacacccgcuuccuugucuaggccugccaccuggcucccccc

accccccuccccggccuaccaaguuucuugcuucccuuacugaccccuccuccucccuccuuugugucuccucccucuccag

agaugcccuguauucaagcucaauauggaacaccagcaacgagcccaggaccgcgugaccaccugaccggugauccccuggcc

cuugaguucggcaagccuaccauggaccuggccagccccgagacagcaccugccgcaccugcuacacugcccagcuucagcac

cuucauggacggguacaccggagaguuugacaccuuccucuaccagcugccggggacgacccagccgugcuccucagcuugu

uccucugccuccuccacgucuucuuccucauccucggccaccucccccgcuucggcguccuucaaguuugaggacuuccagg

uguacggcugcuacccgggcacccugagcggcccauuagaugagacccuauccuccagcggcucugaguacuauggcagucc

cugcucagcccccucgccaucuacacccaacuuccagccgucccagcuuucucccugggacggcucauuuggccacuucuccc

cgagccagacuuaugaaggccucugggcauggacagagcaguugccuaaggcuucuucagggccuccgccaccuccaaccuu

cuucuccuucaguccucccacuggccccagccccagccuggcccagaguucucugaaauuguucccaccaccagccacccacc

agcuuggggagggggagagcuauuccaugccagcagcuuuccccggcuuggcacccaccucuccgaaccgugacacuuccgg

cauucuggacgcacccgugaccuccaccaagucccggagcggggcuucagguggcagcgagggccgcugugcagucugugg

ugacaaugcuucgugucagcacuaugggguccgcaccugugagggcugcaagggcuucuucaagguauuuuguugguucu

gggggacgaugauaucauguuggagguggggguggagugggucauccguugggaucuguagugaccucuccugagguuuc

uucccagcugguucuguccugcaggacgagggacaggugugugccaucuuagaggcugggacuuuuuauucagcagggcac

acaucucucuagggcugcagaaagcuggggaagggggcagaagguguguguguguguggccugcaguggugcucagaaaca

gaaaaccuagugggcagccucugguucuccacagaacuuguguuucuggcacuggaugaaaggacacaggcagaggguuug

guucuugcuggggguggacuugggaacaggcuguguguuugucccagugcugggugccugcuuggcnnnncccaccucca

nccccuuaguccucuccucugcgccaggaaaagggcagguggacacaugcagacaccuguuagaacaggugucuggacggcc

gugggaguuccuagacccuggucuuggguucugggaucuucccugugagguugaaaccuucuccaguaucucccagacucc

ucucugcgcucuggcccuccguuucucccucccccuacauccaaauguuaggaaaauagcuaugaacagagggcgcuuuugu

cugcgucggccacaggaucuggacgguccccuccccugggcucuccaccccccccccaaaccccaugcucugacagccuguuc

cguguccccccuuccuccagcgcacaguacagaaaagcgccaaguacaucugccuggcaaacaaggauugcccuguggacaag

aggcggcggaaccgcugccaguucugccgcuuccagaagugccuggcugugggcauggugaaggaagguggguggcaagau

ggugcccucggcauaggcgaccugauggggugggacagccgggcucaccaggaucugcaccuaauucccacucccacuucua

gauuccagccccuaaaugcagguguagcuuccaccugcuuucuggaaaggguggggugaggagggccuuguggggucccca

ucauggucugaguucucugucucugacuucucagaagugggguguauagugugcccugaagacccuccuucuccaggucuc

cuuucucaauacugcccgucucucugcaguuguacggacagacagccuaaaagggcggcggggccggcuaccuucaaaaccc

aagcagccuccagaugccuccccuaccaaucuucucacuucccucauccgggcacacuuggacuccgggccuagcacugccaa

auuggacuauuccaaggugaggucuugcccgcccaucugcccugcccugagaacauaugcaaugccuuugugccuguuagg

aaaggcucucccuccagggcaacaucaggaaacaagcauccucuauguacuggcuaguuggagaaaugcauugggaugggug

uggggucggggagccaguuacaaacagcugccguagcccuguuuuccugugggaauugacaagcacaugggcccagaauag

ggcucuuuugcacgccuggaucuggugucccagugcaugagagcucuguaaugcagcuuguguaggcuuugcuguggaccc

aaugcaggacacagcugugugaugcaggccuugcuguggagccagugcgugacacagcuguguggugcaggcccucaugug

gaacuuaccugcguuccuuucaguuccaggaacuggugcugccccgcuucgggaaggaagaugccggugacgugcaacaau

uuuaugacuugcucucugguucccuggacguuauccgaaagugggcagaaaaaaucccuggcuucauugagcuuugcccag

gagaccaagaccuguugcuagagucugccuuccuggaacucuucauccuccgccuggcauaccgguaagcugcccaccaucc

uccuagcccuggccccagcccugcggccccggccugccuggacccugaguccugacuguucucugccuucugccagaucuaa

acccggugaggggaagcucaucuucugcucaggccugguacuacaccagcugcagugugcccguggcuuuggugauuggau

ugacaacauccuggccuucucacggucccugcacagcuuggguguugauguucccgccuuugccugccuguccgcucuggu

ccucaucacuggugaguggcagaaacuagacugggcccaaggguugcaggaccauuggguagguagcaucuaacacuuugg

ggaccccuagagugccugcaacauugggauguuaggaccugcaaagggacuuagcucuauucgccccuaaagcuuaaaucag

ccuccgaaugaccccggacuccucagguacgacuguaggcgcugggcaucuagcuuagggauucuguuuguuuaaaaaccu

agcugucaaccucacaagacacaggaacgugcacacaugaauuuuucacauucugcgcuuggauagcuaucgccauggucca

gaaacaggaccuacuucagcucuguugggcucccuccuuauugucucuguaagagguaaccacucugccagccucaguggca

uuccugucauggauuuuacugugcguaucacaggguauggacucuaguguuaaauguagagguuucugggucccuucucg

uuccgcucccauuuccacuuaaauuucuuaggggauccuccugaguagaucaagaccaggagcuggaucuugaaaggguag

ggagugauaucuacacccagcucaguccuuagucuguccugcgagacuccaggauuuuagaacaguguggagccuggaccuc

cagaaaaccuggauuaggcuuuugccuuggccagccauucagugguuucaaauauugaccagucuggacagugggcuccug

ugggacgugcuagagggcuggggaagcuugucagggagaaggcgucaacugagcggggcugacucuaccuucccugcugca

gaucgacacgggcuccaggacccucgucggguggaagagcugcagaaucgcauugcuagcugucugaaggagcacauggcua

ccguggcaggagacccacagccggccagcugccugucacgucugcugggcaaacugccugagcuucggacccugugcacuca

aggccugcagcgcaucuuuugccucaaguuggaggacuugguacccccuccaccuauuguggacaagaucuuuauggacaca

uugucuuucugaccccugcccugaacaugugugcgcacacgugcgugcucuucugucacccaugugccuuuaagccuauag

cccacggacccccagaccacccuacccccagccugguuuugagcuaagacugacguaccuccucacuccagaagauggacaga

gaacucaagaccugggggaggguguguauucacgggggugaccccacuauuugucuuaucccuccagcucaguccuggccu

ucguguguuuuuguaagauaaaccauuuuuaacacauaccacucuguuguaaauaagcugacgcuacuguaaauacagaaag

gaagagguugagauggggguugggaggaagggguggggcucccaccagcugggcgagccuccaacucgagaucucuuccgc

ucuccuuccauguguacauaacugucacucaagaaggugauugacagauucugauuuauauuuguguauuuuccuggauuu

auaggaugugacuuuucugauuaauauauuuaauauauugaauaaaaaauagacauguaguugaaa

89
AF038562
ggcacgaggcugugcccgccaugucugcuacccaucacaagaccucccugccucagggcg

uccgcgugggcacugucaugagaauucgaggcuuggucccugaccaggcuggcagguucc

auguaaaccugcuaugcggugaggagcaaggagcagaugccgccuugcacuuuaacccga

ggcuggacacuuccgagguugucuucaacaccaaacaacaaggcaaauggggccgugagg

agcgaggcaccggcauccccuuccagcgugggcagcccuuugaagugcuccucaucgcca

cagaggaaggcuucaaggcuguggucggggaugacgaauaucuccacuuccaccaccggc

ugccgcccgcccgcguucgcuugguggaagugggcggagacgugcagcugcauucauuga

auaucuucuaagcaaaggacccaagggccuuugcccgguuacggguuggggguuuuuuga

ucccacaagaaagguuuuggaucggccaauaacauuuuucuguuguucugaaaaauuaaa

aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

90
Y11666
gccacauuguugcaccaacuccagugcuggagucucaggacaccaca

ggcuacccggaguuguucugcuuuggagauccgagggcaggagcaucacgccagugacuc

ugauaggugcgaucgccggauuggaacagaacugucauuuuuuuccgaaguugagccuua

gugacccagugagugaaguuagcgacgggacgcuaagcagcuagaccggucggcaggagu

gagacuuaggguaccuucuaguaguugugauuaaaaaaauugaaaaaaagaaaaaaaaaa

acccuguuucuggaaacuugaggcccucagcuggugagccaucgugguuaagcuucuuug

uguggcuccuggagucuucgaucccagccggacacccgggccugguuucaaagcggucgg

acagcgcugccugcuccaucgguagcgcucgagccucgguuucucuauuuggccccgacu

cgccgcaacaagaugaucgccucgcauaugaucgccugcuuauucacggagcucaaccaa

aaccaagugcaga

91
U40930
Sequence below.

cccagcuguuucguccguaccuagaccgcgguuauggcgucguucacggugaaggccuaucuucugggcaaggaggagg

cgacccgcgagauccgccgcuucagcuucugcuucagcccggagccggaggcggaagcccaagccgcggccggcccgggg

cccugcgagaggcugcugagccgaguggcugugcuguuccccacgcugaggccuggcggcuuccaggcgcacuaccgcg

augaggauggggacuugguugccuuuuccagugaugaggagcugacaauggcuauguccuaugugaaagaugacaucu

uccgcaucuacauuaaagagaagaaggagugccggcgggaacaucgcccaccaugugcucaggaggcaccccgaaacaug

gugcaccccaaugugaucugugaugguugcaacgggccuguggugggaacucgcuauaagugcagugugugcccagacu

acgaccugugcagcgugugcgaggggaagggccugcacagggaacacagcaagcucaucuuucccaaccccuuuggccac

cucucugauagcuucucucauagccgcuggcuucggaagcugaaacauggacacuuuggcuggccuggcugggagaugg

gcccaccggggaacuggagcccacguccuccucgugcaggggauggccgcccuugcccuacagcugagucagcuucugcu

ccaccagaagaucccaaugucaauuuccugaagaaugugggggagaguguggcagcugcccucagcccucuaggcauuga

gguugacauugauguggaacauggagggaagagaagccgccugacacccacuaccccagaaaguuccagcacaggcacag

aagacaagaguaacacucagccaagcagcugcucuucggaagucagcaaaccugacggggcuggggagggcccugcucag

ucucugacagagcaaaugaaaaagauagccuuggagucggugggacagccagaggaacagauggagucgggaaacugcuc

aggaggagacgaugacuggacacauuugucuucaaaagaaguggacccaucuacaggugaacuccagucucuacagaugc

cagaaucggaagggccaagcucucuagaccccucacaggaaggacccacagggcugaaggaagcugcccuauacccacauc

ucccaccagaggcugauccccggcugauugagucccucucccagaugcuguccauggguuucucggaugaaggcggcug

gcucaccaggcuccuacagaccaagaauuacgacaucggggcugcucuggacacgauccaguauucgaagcacccuccacc

auugugauagugcuguggccaagccccacccccuuugucuuguaguugcaucacguagagcagcagggcuucuauagau

aggcccagugucuuggcauucuuguagaaucuucaggugggaaugugugaugccuuuucaggcaauaggaaagugcau

gaggagaguuuugaaugugcauaugcugacgccugagaacagacccagguacccguggcugagcugagcuuccucugcu

uccccuaggccuggccucugcagggaacugcagcacacacugcacucccaccugcucuugccgccagcauugcaccagca

guccagaauuccugccugacaacccguguuuccuuuauuaaaagugauuaguacaacugcuaguuauuuucaacaaaua

aagccauuauguuaagaggggacuguccauagugagugaaagguggcaggcaggggccuacagcuccuagggaauggag

aauucaugugaagccgaaugaaggaucuuaucuuauacugucccccuuucuaauggccacucuuuaguguuugugucua

auguuaaugcuuaaagcacaggacccccauguagcuuccucugacuugguuuguaaguaaccuguaauaaaaugccaua

ugcacuuuaacca

92
D26090
Sequence below.

gagggaauugcgggaccccgucuggggaagcucccgccgccccggggugcucagcucucugucucccuugacccaggua

cagucaugucgggcuucgacgacccgggcauuuucuacagcgacagcuucgguggcgaccccggugcggaagagggcca

ggcccgcaagucgcaacugcagaggcgauucaaggaguuccugagacaguaccgagugggcaccgaucgcacgggcuuca

ccuucaaguacagagaugaacucaagcggcauuacaaccugggugaauacuggaucgagguggagauggaggaccuggcc

aguuuugacgaggaacuggcugaccacuugcauaaacagccggccgagcacuuacagcugcuugaggaagcugccaagga

gguggcagaugaggugacccggccccggccagcuggagaugagcugcuccaagacauccaggucaugcucaagucagaug

ccagcccgucgagcauucggauucugaagucagacaugaugucacaccuggugaagaucccuggcaucaucauuucagcc

ucugcaguccgugccaaggcuacucguaucuccauucagugccgcagcugccacaacacccucaccaauaucgccaugcc

caggccuagagggcuaugccuucccaggaagugcaauauggaucaggcugggcgcccaaagugcccacuggauccauacu

ucaucaugccugacaagugcaaguguguggacuuccagacucugaaacugcaggagcugccugaugcagucccucaugg

ugagaugcccaggcacaugcagcuuuauugugacagguaccugugugacaagguuguuccugggaacagggucaccauc

augggcauuuauuccaucaagaaguuuggcuugaaccccagcaagggccgggacaggguaggugugggcauccggagcu

cguacauccgagugcugggcauccagguggacacagauggcucuggccgaagcuuugcugggucugucagcccacagga

agaggaggaauuucgucgccuggcugcccuccccaacauauaugagcucaucuccaagagcauuucccccuccaucuuug

ggggcauggauaugaagaaggccauugccugccugcuuuuuggggguucccggaagaggcucccagauggacucacucg

ccgaggugauaucaacuugcugauguugggagacccugguacagccaagucucagcuucugaaguuuguggagaagugc

ucucccauugggguguacacaucugggaaagguagcagugcugcaggcuugacugccucagugauacgggaccccucau

cucgaaacuucaucauggaagguggagccaugguucuggccgauggugggguugucuguauugaugaguuugacaaga

ugcgggaagaugaccguguugcaauccaugaggcuauggagcagcagaccaucuccauugcuaaagcugggaucacuacc

accuugaacucucgcugcucuguucuggcugcagccaacucaguguuuggccgaugggaugagacaaaaggggaggaca

auauugacuucaugccuaccaucuugucccgauuugauaugaucuucaucgucaaagaugagcacaaugaggagaggga

caugaugcuagccaaacaugugaugacucugcaugugagugcacugacacagacacaggcuguggagggugagaucgac

cuggccaagaugaagaaguucauugccuacugccgagcgagguguggaccucggcuaucagcagaggcagcagagaagcu

gaagaaccgcuacaucaucaugcggaguggggcucgucagcaugagagggacagugaccggcguuccagcauccccauca

cugugcggcagcuggaggcuauugugcgcauugcugaggcccucaguaagaugaaacugcagcccuuugccacugaggc

ugauguagaggaggcauugagacuguuccagguguccacacuggaugcugcuuugucuggcaaucugucgggggugga

gggcuucacuacccaggaggaccaggagaugcugagccgcauugagaagcaacucaagcgccguuuugccauuggcucuc

aggugucugaacacagcauuguccaggacuucaccaaacagaaauauccagagcacgcuauccgaaaggugcugcagcuc

augcuacgcaggggugagauccaacaccguaugcagcgcaaggugcucuaucgccucaagugagcccauugcccaucaac

ccucaagccugaaaugcugccaccacccuaucucccagucagugcuccaaaccuccuuuugcccugccucuccaccucaga

cugcugucugcagcacaucugcagccccuggaaauguacuuuggucuguuggcucauacuguguuugagugucugagg

acucucugcucugggugucuauccccugucaugccuucucaacaagaugagucuggagcaggaacaggcccuggaaugu

agaugggucuguauauuggcucccgggccacucacugccaagcuucuuuguauguacagagguaauaaagcaauugagu

cccuggcugcuaaggucaguggacccagu

93
AI787627
ggaugcagccggaagugcagcgugcgugcgguuuggugggucgcugugugcgcuccgcgu

gugcagccgcgugggccauggggcggcgggcgcggggccggcgguuccagcagccgccgc

agccugagggcgaggaagacgccagcgacggcggcagaaagcgaggccaggcgggcuggg

aagguggcuaucccgagaucguaaaggagaacaagcucuucgagcacuacuaucaggaac

ucaagaucgugccagagggagaaugggaccaauucauggagucacuccgagaaccucucc

cagccacacugagaaucacuggguacaaaagccaugccaaagagauucuccauugcuuga

agaacaaguacuuuaaggaguuggagganccugaaguagauggacagaaaguugaguucc

acaaccacuaagcugguacccugaagaacu

94
M33988
gagcucaaauucuggcuuucuauuggguacgauauauuaaccaaugggagaaacacaaac

agaauaccuccaguuaguauaaaugcuugcuguucaguugcagaauuuacuauauauucu

uuuccuuucucugcuuugccuuuacugauacuuaaacgcauacaugucuggacgcggaaa

gcaagggugcaaggcccgcgcuaaggccaagacccgcuccucccgggccggccugcaguu

ccccgugggccgcgugcaccggcugcuccgcaagggcaacuacucggagcgcgugggcgc

cggcgccccgguguaccuggcggcugugcuggaguaccugacggccgagauccuggagcu

ggcgggcaaugcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccugcagcu

ggccauccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcaggg

cggcguccugcccaacauccaggccgugcugcugcccaagaagaccgagagccaccacaa

ggccaaggggaaguaaucuggcgauugucuguacugcccaguugaaaguuaaccaaaaca

aaggcucuuuucagagccacccacaucuuuccauaaaaugagcugccaccucgugaaacg

uucuuccacuacaguuuuuauacuacauaugaaaaaguuacgaaguagcuuucaaucuua

guaaauugauuuuaauacuguuagucccugcgauaaaucuuacgaccuuccuuaguuuga

gucaaaaguguguaagagaugaaaccuuuagaacauacuauaaauuuuuaguagaaauuu

ggcacccagguuugucauucacgucacgauugucuagagcauaaugguaguaagggcuaa

gggccauuaaaucccacuuccauaguuuc

95
AI845182
uuuuuuuuuuuuuuuuuggaaaugaagguaauuuauugaaacugguuuugggacaggcga

guggacaacuguugaaaggagcuagcgcacagccgggugggagcgggugcuuagccacag

auccuaucugaggcccaacuuuuucuuuuccuucugcuucuuacggaccacauccagguu

ccgguccuuccacaugcuuuugcgaagcuugauggggcgugagcccacauacuucccauu

caucucucgcauggcgcgcacauagucacuggggucuuugaagcugacaaagccauagcc

cuugguuuugccugugcgcuuguca

96
AA619207
uucggauccuugccaauauauguaucccauuuggaauggugaucuuaaaaugugagugca

ugcauacuaucuuauuuaagauacuugcaccccacccacucccaucucccgaagcuggaa

cacugccaacuagguccuuaagaaucacgcaauuaacacaagguugggugcugcuaauuc

uucaugaaaauccaaacacguuaagggaccagggagaugccacugccccccugaauuuuc

aucaaaaauagacacguuuauguaaacagaacuauuuuccauauucauagugacuuuuua

aguauuugagccuaaagauuuugaucuccauuuuuauaacuauuuaaauuguucacaauu

auuacau

97
AW125783
cggccgccgccgcccccacacugccccgcguugacgagcgccgcgacggcaaggacagcg

ccucgcuuuucgugguggcucggauccuagcggaccucaaccagcaggcgccggcgcccg

cccccgcggaacgcagagaaggggccgcugcgcgcaaggcgaggacccccugccgccugc

cgccugcgcccccugcgccgccacccggcccagagcccgccuccccgggacaagcaggcg

cgccggccgcgccccccagccccgcguggagcgagccggaggcggcauuggagcaggagc

ccggccccgcggggagcggcgagccuggccucagacaaaggggucggggaggccggagcc

gcgcggaccucgaguccccgcagaggaagcacaagugccacuacgcgggcugcgagaa

98
J04103
Sequence below.

cgucaguccccgccaccuccccggccccgcgcgcccggaucggcccuacggccucgucucgcccggccuugcgcgccgggacc

gccgcgaucuccucuccccgccgcccuccggcuggcccugccugcugcggcgcgaugaaugacuuuggaaucaagaacaugg

accaaguggccccugucgccaacaguuuucgugggacacucaagcgccagccagccuuugacaccuucgauggcucucuguu

ugcugugcucccuucucucagugaagaucagacacuccaagaagugcccacgggccuggauucugucucccaugacucggcc

agcugcgagcugccuuugcucacucccugcagcaaggcagugaugagccaagccuuaaaagccaccuucaguggcuuccaaa

aggagcaacgacgucuuggcauccccaaaaaccccuggcuguggagcgagcagcaggugugccaguggcuucucugggccac

caacgaguucagccuggugaaugugaaccugcaccaguuuggcaugaacggccagaugcuguguaaccucggcaaggagcgc

uuccuggagcuggcgccugacuuugugggugacauccucugggaacaucuagagcagaugaucaaagagaaccaagaaaaga

cagaagaccaauaugaggaaaacucucaccucaacgcgguuccucauuggaucaacagcaauacauuaggcuucagcauggaa

caggcuccauauggaaugcaggcaccaaacuaccccaaagacaaucuccuggacagcaugugcccgccaucggccacgccugc

agcucugggcucugagcuccagauguugcccaagucucggcucaacaccgucaaugucaauuacuguuccaucagccaggac

uuccccagcagcaacgugaauuugcucaacaacaauucuggaaaacccaaggaccacgacucuccagagaacgguggggacag

cuucgagagcuccgacucgcugcugagguccuggaacagccagucgucccuacuggauguacagcggguaccuuccuucgag

agcuuugaggaggacuguagccagucucugugccucaguaagcugaccauguccuucaaggacuacauccaagagaggagcg

acccagucgagcaaggcaaaccaguuauuccugcagcaguacuggcuggcuucacuggaagcggaccaauccaguuguggca

guuucuucuggagcuacucucugacaaguccugucaaucuuucaucagcuggacgggggauggaugggaguucaagcuugc

ugaccccgaugagguugcccgccggugggggaagaggaaaaauaaaccaaagaugaacuacgagaagcugagccggggcuua

cguuacuacuacgacaagaacaucauccacaagacuucgggcaagcgcuacguguaccguuucguaugugaccugcagaacu

ugcugggcuucacuccggaggaacugcaugccauccugggcguccagccugauacagaagacugagggccuca

99
D90146
Sequence below.

auggcucuaacaacgcugcucuuggugguggcggccgcccugacccugaucgagacccgcgcgggugagugcggggucggg

agggaaacagccccugugccgcguccccgcuucgcccaccggaccuccgccccuucuccacccgagccccgagcccugcucca

cucccggcccgcguacccgaccggggucccgggaggaggucggggucucaccgcgcgccgcccccaggcccacacucgcugc

gguauuuccacaccgcugugucccggcccggacucggggagccccgguucaucaucgucggcuacguggacgacacgcaguu

cgugcgcuucgacagagacgcggaaaauccgaggauggagccgcgggcgcgguggauggagcaggaggggccggaguauug

ggagcgggagacacagaucgccaagggccaugagcagaguuuccaagggagccugaggacugcacagagcuacuacaaccag

agcaagggcggugagugaccccgggucggaggucacuaccucuccacgucccgaaacagaggccggugaggucccgggugca

aaguccgagguucaggagcagaacugacccaggacuggauucccuuucaguuuggaggaguccgcgguggggggguggggg

gggggcggaggagggacugaccacugggucccgcaggcucucacacacuccaguggauguauggcugugacaugggguccg

acgggcgccuccuccgcggguaccugcaguucgccuaugaaggccgcgauuacaucgcccugaacgaagaccugaaaacgug

gacggcggcggacauggaggcacagaucacccgacgcaagugggagcaggcugguauugcagagagagaccgggccuaccug

gaggucgcgugaggcuccgcagauaccugcagcucgggaaggagacgcugcugcgcacaggugcaggggccgcgggcagcuc

cucccucugcccucaggcuggggcucaguccuggggaagaagaaacccucagcugggguggugccccuggcucagagggga

gagagugacccugggucuccugaucccucaucacagugacugcacugacucucccagggcucagccuucucccuggacagug

cccaggcugucucaggagggaaggagagaauuucccugagguaacaacagcugcucccuucaguuccccuguagccucuguc

agccauggccucucccaggccaggguucucagccuacacccacugucuguagacacugacuccuguccugcugaguguguca

gcccuuacaccucaugaccugaagucuccuuuacccgaugggagacauggacaucuacacuaggcugguucccccaguuucu

agaacuuuccaaagaauacagucuaccagauccuucccugucugugggguuugcauccuuugacacccaauucuaucuauuc

cugcaauggugaauagucacaugagccauuauggguuacccuaaacaaauacuuuucuuguguuuuuccccucucguuuuc

uuuuuaucuuuacuuuuuuuuuaaggguauuauguugcuuauaaucgguuuuucuucggcacuggaaugauauugcucuc

ucuccccaccauacccccacccccgccuauaucauuuguaucaguagcccuggcugucguggaacucacucuguagaccagg

cuggccuugaacucagaaaucagccugccucugucucugccucugccucccaagugcugggauuaaaggcuugggccaccac

cacugggcagaagaaagguuccugugagcuuaaaauguuuucuggcagaauuaaccauccagaucacuccugauaucccugu

gccccaccaaguuacagugcucccccuggugaaucagaacuuggacucugagagacagggucuucugcaauccaggccugag

ugagagggaagaccacacacccugugagcccacuguguuccagugagugcugcacugggguccacagcacauuccagggauc

cugugugacacaucuguaccuugucccccagagucaggggcugggagucauuuucucuggcugagugucagagguucacca

cauuucugcuacacacucccugauggcuguuuacuuggacugacaguuaauguuggucagcaagaugaccacagugguuua

gucucaauggugucacucuuccaguagcauaugguccugauuucuaauuuagauacgaacucaaacacauaugaaauuucu

uauuuuccauuccaucuuccauuauauagcuaccuaucucgugcuauugaacaucacauaaggaugaccauguugacccacu

ggcucauguggauucccucuuagcuucugaguccccucaggaaaaugugcaguccugugcugagggggccagcucugccug

caggucacuagugccaugacaguuaaaguguucauacagacacauaguucauuguaauuacugauuuagcguugucuuggc

aguuuucaguuugcaugcauuuauuuauuuauuuauuuauuuauuuauuuauuuaaugcauggaaguacacuguugcugu

acugaugguuguuugccuuugugugguuguugggaauugaauuuuuuuuuuuaggaccucucuuugcucuggucgaccc

ugcucacuccggucaacuccuaugggucaacucugcucauucagucccugcuuguucuggcccaaagauuuauuuauuauu

uauuauacauaaauacacuguagcugacuucagaugcaccagaagagggcgucagaucucauuacagaugguugugagccac

caugugguugcuggaguuugaacucaggaccuucaaaagagcagucagugcucuuacccucugagccaucuccccaguccuc

aguuugucuucuuaauugugcgauuucuugaaucuuccaaacagaucccccaaagacacaugugacccaucaccccauaucu

uaugaugcugucacccugaggugcugggcccugggcuucuacccuguugacaucacccugacuuggcaguugaauggggag

gagcugacccaggacacggagcuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugugauggug

ccuuuuggggaggagcagaauuacacaugccaugugcaccaugaggggcugccugagccccucacccugagaugggguaagg

agggugugggugcagagcuguggucagggaaagcuggagcauucugcagacucugagcuggucagggcugagagcuggga

ucaugacccucaccuucauuuccuguaccuguccuucccagagccuccuccauacacugucuccaacauggcgaccauugcu

auugugguugaccuuggagcuguggccaucauuggagcugugguggcuuuugugaugaauaggaggugaaacacagguag

gaaagggcagggucugaguucucucucagucuccuuuagaagugugcucuaaucauuaaugggaaacccaucuacaccccac

auugcuaccuucuccaacuggguccucugucaguucugggaacuuccaagaucuuccuugaacucucacagcuuuccuucu

cacagguggacaaggaggggacugugcuccagcuccagguuaguguggggacaggauuguccuguggacauugcagugaag

cuggagauguuggggagcucugggaacccauaguaacucuuccagagaaaucuuccagggccgcaguuguccaauaugaaua

cauauauguacauaugcauauacauuuuuuacccuuggcagggacagcuccuagagcucugauagaucucucccagguggu

aaaggugacacucugggaccugauuggggaggggcaauguggauaugauuggguuucagggacuccacgaauccccucuga

gugagugguggguuguuggaauguugucuucacagugaugggucgugucccuc

100
AI563854
uuaaaucuggagggauuuuucacacagccuaucuuuuuaggugugccuuucccauauuuu

auuaaacucgaguuguuguuuuaaaaaaacagcagcauuaucaaagacacaucuguacaa

acauuuuacaaaagagaacucucuaggaucagcuacaucaaggacaagcagaaaaauaga

ugcaguccaacaaagacauugaaaaugacuu

101
AF017128
Sequence below.

ggucgcuuucugucuguagaggcggcuugccacccgagcagagggucgugaaguuccgaccggaccgguccacagaggu

ucaucuggagagguggguccccuccgaggugaaaggcgccgcugagaaacgcccccaccccccgugguucaagugguuca

gcccaagaacuuuucauucauaaaaaagaccagacuccgagaggcgcgagugagucagaaccgcagccgccaacgcggacc

cuaccgaacauccagcccagggcauguaccgagacuacggggaaccgggaccgagcuccggggcuggcagcccguacggu

cgccccgcgcagcccccgcaagcucaggcacagaccgcccagcagcaggugagacuggccgaaucgucgggggggggggg

accugaguuuggacagcaucagggaugcugggauuagucuaguuugcuccgggauuuggacuggggccccgagcagcau

cugacucugguggucgcgaccgaggauccugcacguucuguguggucggggaaccuauguacccgguggccaaggggac

gagcgcagcgggaagcgcgaauaucugcgaauuccccuucucgcucgcccguaucucccuagcugacugucuuucugccc

cuccgucuccguuacggucuuacauuuccuccuaucugccccuaauacgcugucccucuaaauaccugccccaucccugc

cuggacaggaucagagguguucuccaucuccaguuaauaacugggaccuggggucugggcacauagagacgggguccau

cagaacucagccgggacagagaauucuuagcagccuguccgaggcuguccguguguugcucugguuguccgugucccuu

uauccggucaaguccucaucucuuugugcgcaguauagagcccaugggccccaggcagugguuccgagggguuccugga

gaccacgaaguguugggaugugcgcggggucaccugcccggccacacucgcgcuccacauucucggcacccgacgucucu

cacugcuggauaggggcacuugagagguugcagguguccauuuccugucgaggggccgcgagcacgugucgccagggga

gggaaggagcugcguccguuucgccgagucacagcgggccgagucacugaggcugagucacccugggugccccucccuu

ccuggccccaaacggccccuaaggaccgacgaccugggagcgagagaugccccuggcagugcuucuagcccagaacgggg

gucacugagaugcugggucccccaguauugggcuggggacauagcuguccagacuugccuaagcaugugaggugcuucc

uggacuggagggcccccacauccuuagcucacagagcuugaacccaguuuucucucccagaacgcugagcccccaccccca

ccgacacucaaucccaacacaugccucagauuucugcaagaaaaggaaggaaaggaugccagaccccuuauaggaggcuuu

uacucucuucacuuuauuucauggacuuaaaaaaccccaucaauuuugaacuuucaaguuuuuaagucgacagcuaggca

ugcauuuaaucccagcauucaggaggcagaggcaggcagaucucugggaguuugaagccaauuuggucuacaaagugac

uuccaggucagcuagagcuacauaauagagauccugucucaaaacuuaaaaaauaaaaaacaaaaacaaaagccgauuaaa

acucugauuucugagcuaugagagcuggcuucucaacagcaauggaacguugaaugauguuaauaacagggaaacugag

acuaaauaacaugccccagucucaaagcccaucaauggccaagcuccaagcugaugcuggacucccaagcucuggugcuac

augucuauagucuuggugccugggagguagaggcagaggaaucgugaguuuaggucuagccugagcuaugugagaucc

ugcccaccccacccccggcccccaaacaacaaauucucauccugauucucagaauugccuugggagcuagaagcugaaagu

augcccaucugugaggacugggucucaaaucuuaguuucuacuuacuagcugugggucuaugggcaacugcucuccugu

cugaaaacaggauuauggcagcugugugagucacuauuuguuaaauaguuggaacaguguuacgcaguccauacuugau

uuaaaacaaaaaaccaaacuaucucugguggggaaacagacagacgaagagagacauuuugugaccugcccaaaaucacac

agcuccugaacaaguaaguuucugguugccaaauguugcuccuuguggucucccaaaacugguaucuacacugagguga

agggagacagaaguccagccucuguccccgggaagccccucaguccacacagaccuuaucauuucccuucuuaucucuca

gaaguuccaccuugugccaagcaucgacagcagcagccaggaacugcacuggauggugcagccucauuuccugggaccca

cuggcuauccccgaccucuggccuauccccaguacagucccccucagccccggccaggagucauacgagcccuagggccac

cuccgggggugcgucgcaggcccugcgagcagguaagaaacagcgauguuucacuuuccauagcccguagggguccuac

uagacagggacaggaucuugcuacgagggaauuucuuauucagcauugaaguuccugagaggccaagaaggagguaaaa

ggucaccuuugagucaaggaaggcuuccuggagaaggcuacacguuaaccuaaaccacggauaggauuugcguauggaa

gcugaaaagaaucuucugggaggaggguuggaggcacagaauugaggugaaggggacagaguguuaagugagcaugucu

ccacugucugacgugcacaggguggaaggaagccugaugcuggcuuuguaccucggggugacucuucuuuucaacaguc

acggaaucucagccuauuucuuuuaauuaucacaaaaagugagugggcagugguggcucacaccuuaaauuucagcacug

gggaggcagaggcagguggaucucuggguucaaggccagccugguuuacagagugaguuccaggacagccaaggcuaca

gagaaacccugucucaagaaagggaaaaaaaaagugaaugggaaauguauuucaauuuuuccaucuuccaucagaggaag

ugaagcauagagggguacucacuuguccagauucauacaaaugugaguaaugagacaggacugguccuggccugagguc

uacucaacucccaaagucagagcuuaaugagccacugucucaaugggagcucacagaagccugcagagggagugagcuga

gaacuuuugccucccugaaugccuuucuaaaauaaagaaggguguguuuugguugguuuguagagguggggucuugag

agccuccugccuucccaagugcuaggaguauagguguaugcuagauacccgacagggaugacggaucuuuuaggccaua

gcacuuucuuuccucucccugaaguacugagacugagucuagugcagggaggccuccauacuaaaaagcuggguguaccc

guaaucccagaacucggaaaaucaagacaggaggagccauucaagucacgcucagaaacauggagaguuuaaggucagcc

ugggauauauaaacccuaucuccgauaaccaaacaacaaucaaagcaaaccugacuuaaguguuaaguaggaaagaauaug

cuguaagucaucagccuggcugggggacugaccgccucugagggacugaagaaccugcuucaagcccggagcccugcacu

caaccccuaguggaugcacacacagauccuugccaugauggcucgaagagggauggcaagacccugggagauaugugaga

uuggccagagaagagccagcaacaggcuucccagcaagggaacagcuuaccucugugaucagcuggggcgugagcaagag

gcaagcccagggugaauccuuccuuuagcccuguccugaggagacaccuuuugaccacggguacuaguggguuggagcu

gugagcuguggguagguggcuuccccucggugugcucuggaacuugaacaaaucacucauccuuccugagcuuccucac

augugagugugcagagaucuggaugggugacucagcagcggcucuggcugcuccuuagaggauccggguuccaaucuca

gcacccacguggcaacucacuguccacaacgucccccaaagguucugaugcccucuucuggccuccaccagcacugaaugc

acaaggugcucauacaaacacacaggcaaaauacucagagguaaauuuguucuuuuuuuucuuuugagacaggguuucu

cuguauagcccuggcuguccuagaacucacucuacagaccaggcuggccucaaacucacagaggcaucugccugccuccc

aaguguugggaccaaagauguaugccaucacuauaagccuuuuuuuuuuuuguaaauuuuauuuaugaaugagugcuuc

cauguauaccuucaugccaggagagggcaucagauccuauuauaggugguugugagccaccguguguggcugggauuug

aacucaggaccucugaaagaggagcucuuaacugcuaaaacaucucucuagccccagucuacauauuuuaaaucuuuuuu

uaagauugauuuauuuauuauacauaaguacauuguagcugucuucagacacuccagaagagggcgucagaucuuguua

uggaugauugugagccaccaugugguugcugggauuugaacucaggaccuuuggaagaguagucaaugcucuuacccgc

ugagccaucucaccagccccuuuuuuaaucuuuaaaaaaaaaagggggggggccuggagagauggcucagccguuaagag

cacugaaugcuuuuccagagguccugaguucaauucccaacaaccacaugguagcucacaaccaucuguaaugggaucca

augcccucuucugguguaucugaagacagcaagggucuacucacauauguuaaauaaauaaauaaaaauuuaaaagccag

gugguguugguucagacagcagaucucuguuuaaggccagccuggucugaucuacaaaccaaguuccaggacagccagg

gcuacacagagaaacccucuaaaaaaccaaucuauguagggggugcuggugaaauggcuccguggguaaagguacuugcu

gcgaaauuaaugaccugaguucaauccuugaaauccacacaguagaaggagagaaccaaccuccaagggugcuaugacaca

cacacacacacacacacacacacacacacacacacacacacacacacgacuauauauaugaauauaugacucuagccaggca

uaguguggcacaugccuuuaaucacaguacuugggaggcagaggcaggugaaguuugaggccagccuacagagugaauu

ccaugacagcuagaacuaugaagaugaacccugucuuuaaaaacaacagcaacauaaagaaucuauguagggaagcuggaa

gggaugcugauacagucugcaauccuauuacucuagagguggaagccaaagaaucagggguuucaggccggucuugccu

auacacugagcuaaaggccagccugggacacaugagacuuugucucuuuuaaaaagacaaaacaaggggguugguuagau

ggcucaguggguaagagcacccaacugcucuucugcagguccgaaguucaaaucccagcaaccacaugguggcucacaac

caucuguaacgaaaucugagucccucuucuggagugucugaaaacaacuacaguguacuuacauauaauaaaaauaaaua

aaucuuaaaaaaaaaaaaaaaagacaaaacaagccagaugaggucugugaguuccaggccagccuggucuauaaaucaagu

ucaaggccaggcagggcuacucagagauucugucuaaaauacaaagaaacaaaacuacaaaaagcagaaaaaggaaucuac

gaaagggcuggugaagggguguaacucagugguagagcauuugccgagcuagcauguaccaagccauggguuugauccc

uagcacuaagcaaaagaaaaguccuacaaagggcuuuguuggcauaguagauugauucccaguagcuuuuggcacucaag

agcaccuucuacaauucacagcuccugggggaagaaaucccaucuuccacagaugaggaggcugagaguccugugaaaag

agauaaucaugucucauacacucaggagagaaggcuacuucugccugagaaaugaaaaggcuuccuggggucccaacauc

uuaguccaguccuaagaugcggaagggaggaagaucaaaguuuacagagagggaaagcauuucaggaaagaaaccagcag

uaaagcuaggugugugugagcuggaaaugucaccaaugagaugacaagcguccgguacagagaagcaacuguggagugu

ugggugguggcaccuagacuacagacugaaggaaagcuggaugaccagcucagggcagcugguggcucagagucagccu

cauugucucccuucuucuaucccaaccuagaucagcccagaggaggaagagcgccgcagggugagacgcgagcggaacaa

gcuagcagcugcuaagugcagaaaccgaagaaaggagcugacagacuuccugcaggcggugagcaucauccccaggcccg

gacccacagagccccaagaggggucucggcucccaagaacacaaaagacccaaaauuacuccucaggacucugucauccuc

ccugccuguggggaaguccuggaaaaaggauaagggaaaguggcuuaaauauuguuugucgggcuucgaggcagagucg

aagaugguaggcagcaauucuccuaagaugcccccgucugaugggagucauggccauuuucucccagaggcucacggga

gggaguugcaguccagacuuguuggggaugacaggcacagucccuacuccagccugaggcuuggggaucuuuagccuuc

auuuuccuaucuuucugcuaauccuguaaaggagaccgacaaauuggaggaugagaaaucggggcugcagcgagagauu

gaagagcugcagaagcagaaggaacgccuugagcuggugcuggaagcccaucgccccaucugcaaaaucccagaaggaga

caagaaggacccaggugguucuggcagcaccagcggugcuagcagcccaccagcccccggccgcccagugccuugcaucu

cccuuucuccaggacccguacuugaaccggaagcacugcauacccccacgcucaugaccacacccucucugacuccuuuua

cuccgagucugguuuucaccuauccuagcacaccagaaccuugcuccuccgcucaccgaaagaguagcagcagcaguggc

gaccccuccuccgacccccugggcucuccuacacuccuggcuuugugaggcacccagccacaucccuugcuggugcuacu

ccaagccauccccuuucucccauugauccagcaggccuggaccauacccuugccccaaaccagcagaucuuuuaucucuuc

cgacuagaacaaacacauuaugcuuugauguagagccagcuuggaggggauccccaaagcugcucacuguuuuucuagag

cuggccuaucauaauuugcacaaaauuagaggaaaauauguucccucugccagagaacgccuggcagcccagacuuugua

gauccccagggguccuuugacacccuuaccccuugcagaccacuuucccacaccacgucacuuucuucauguuauccagc

cuacucuacaccuagacagaaggugcccuuugacuagccuagaacacuaacucacacagcaucaacagccagcagcaccgg

acauccugcaggcuccuccugaauggcacaacgcaggaggcgccaggggcuucugugaggagcggagcugcacucccuag

cucugagaagcgcuuagcuucaggguauccgagccuccaccgcaagggcagcugcuauuuauuuuccuaaagagacuauuuuuaua

caaaccuuccaaaauggaauaaaaggcuug

102
X67644
Sequence below.

ccguggguuccuaauggugcuauugacgacgggcacaaagucucauaauuuuagaaacuucacuuauuuugugacccaccu

aguauggggcaaaggcaggagcuucggacuuccugucuucccucuaucccuuugaauagcgucucgggagugucccuaagu

aaccauugcaguuuuguguccgugugcucuguugaaaucucugugauguguguaugguuuucacgugaacggaggcaggc

agagcccggucuguggguucuaguguguucuuuaucuucuuggaaguuugugcaaugacuucccuccuguuuccugcgca

uaccuccaaguaaguacgugaauguguuuucuguggucccuugaucuugcuggacuucacuaaggaggguggcuggaccau

cugcuacgugucugagagccccucucuagcuaccucauguccggacgugagcuuacucccaauguuuuuacccacaagcauu

cacuacucccaggaaagaacgugcacuggggcaccuagagaauaaccaaucaacgcuccgccuacauuuugcuuccuccuug

gaauuuccagccccuugcagccaacugcuccccagcugcgaagggcggaguuccccccggcccggccccuucuuuggcucua

uaaguagcucugcuuugcgggggauuugcacuccucuacacucucugcacaacgucuaaauuaugugccacucgcgcaacca

ucuccacaccaugacuggccugagggccccuucuccagcucccuccaccggcccggaacuccggcggggcucuggucccgaa

auuuucaccuucgacccucucccggagcgggccgugguguccaccgcgcguuugaacacuucucgcgggcaccgaaaacgca

gccgaagggugcucuacccucgaguggugaguaucgcccgagugggcaucaggaggucgcgucgcccuggaacuuguaggu

aacaacuaggagcagggaccuucgaucugacguuucccucuuuuaucugcucagguccggcgccagcuaccaaccgaggaac

ccaacauugccaagaggguccucuuucuccuguucgccaucaucuucugccagauuuugauggcugaagagggugugucgc

agccccuggcuccggaggaugcuaccagcgccgugacaccugagcccauuucugcgcccauuacugcgcccccgguccucga

gccuuugaaccugaccucggaguccucggacuaugcgcuggaucuuaaagcuuuucucuagcaacauccggcggccuucuaa

acgcgaugggucacaguccgaagaaacaaaggcaccauggauggguaccuggugcgagagaacguaucccaaacugggauuu

cuaaggcaacgcuaacucagaacacuaccgccaagagacaccgcggguccuggcuaggcccacuggggacggacagagacuuu

cuccgugucuaauuaauauuuauguauuuauguauauccuccuaggugaaggagggguguauguaauauuuauucuaacu

uaugcaggggugcgagauaugccucccugcuguaacacagauauuuauuacgauuuauagggucgguaagacagaguugug

ggagggaggacccgggugguaggacucccagcuuggggauuagucugggggggguguaauaagauuagggguaacacuccg

ucuuccagcacuucaacucuguagucuguuguaaggcuuuggaagacccuugggaauccggccuuugaugucuucugguug

cuucucaggggcagcugcaggagucuuggguccauggauugucagagggcggcugucuggggucgccuaguauguauguu

cugugaacacgaauaaacuugauuugccugucauuauuaucugcaguucucgaaguguaucauucag

103
AF064088
See above (same Accession Number).

104
AI843085
uuuuuuuuuuuuuuuuuaaauugccgaauuaaguucuuuuaauagauugcauauauagau

guuuagccauacucuagaucaacucuuuaagaguagaauuuuauauccaauuuacaugcu

ucagauaucaccucuguuuguuacauaaggucuuguauccaaauguccacuuguacacug

agagcuuuaggaacaaaaaaggacacagagagaguugccauuuuuagcagcaaugaaaca

ucacuaaccccuuuuuacauaccgaauucaagucacuac

105
AW124932
cggccgccgguauuuuuuugcaaguauugagaguucuguauguuuugaaaagaguaauuu

uaacguuugggugccaagaaguggguuuucucagaguccauugccggcaaugggcaagcc

uggcgguacuccucgugccgaau

106
X58609
augg

cgcugggaacgcugcuccugcugcuggcggccgcccuggcccggacccagaaccgagccg

gugagugcagggucgggagggaaacagaacuuuccaaacagucugcggggaggggcgggu

gcggcaccggggaagccgcgugcccgcgucgcccaccagacccuccgucucuuuacccgc

gucccuagccccgcgcccugcuccccuccugucccgcgcauccgcccggggucccgggag

aaggucggggucucaccgcgcgccgcccccaggcucacacucgaugcgguauuucgagac

cgucgugucccggccgggccucggggagccccgguacgucucugucggcuacguggacga

cacggaguucgugcgcuucgacagcgacgcggagaaaccgagguaugagccgcgggcgcg

guggauggagcaggaggggccggaguauugggagcggaucacgcagaucgccaagggcca

ugagcagugguuccgagugagccugaggaaacugcuaggcuacuacaaccagagcgcggg

cggugagugaccccgggucggaggucaggccccuccacuucccgacacagggacgcugac

guccugguucccaagucugagguucgggaacagaacggacccgggaccgguuucccuuuc

aguuuggaggaguccgcgggugggcggggcugaccgcggggucccgcagguucucacaca

cuccaggagauguauggcugugaugugggaucggacgggcgccuccuccgcggguaccgg

caguccgccuaugauggcugcgauuacauugcccugaacgaagaccugaaaaccuggacu

gcgaaggauguggcagcgcugaucaccagacgcaagugggagcaggauggugcugcagag

uauuacaaggcuuacauggagggcgagugcgugcagucgcuccgcagauaccuggagcuc

gggaaggagacgcugcugcgcacag

107
M18837
Sequence below.

auggcgucaacaaugcugcuucugcugguggcagucgcccagacccugaucgagauccgcgcgggugaguaccggguccgg

agggaaauggccucugaggaaaggggagggggcggcacgggggaagccgcgucccggcgucgcccaccugacccuccgcccc

uucuccacccuagccccgcgcccugcuccccucccggcccgcucacccgcgggggucccggaaggaguucggggucucaccg

cgcccugccuccaggcccacacuugcugaguuauuucuacaccuccgugucccggccgggccuuggggagccccgguucauc

ucugucgguuacguggacaacacggaguucgugcgcuucgacagcgacgcggagaauccgagauaugagccgcgggcaccgu

ggauggagcaggaggggccggaguauugggagcgggaaacacagaaagccaagggcaaugagcagauuuuccgagugaaccu

gaggacccugcucagcuacuacaaccagagcgcgggcggugagugaccccggaucggaggucacgaccccuccacgucccaaa

acaggggcccgagacgucccgggccccaaguucgagguucugagcagaacggacgcgggacugguuucccuuucaguuugg

aggagccgcgggugggcggggccggggcgugugggcggggcugaccgcggggucccgcaggcucucacacuauucagguga

ucucuggcugugaagugggguccgacgggcgccuccuccgcggguaccagcaguucgccuacgacggccgcgauuacaucgc

ccugaacgaagaccugaaaacguggacggcggcggacauggcggcacagaucacccgacgcaagugggagcaggcuggugcu

acagagaaaagcaaggccuaccuggagggcgcgugcgugcagucccuccgcagauaccuggagcucgggaaggagacgcugc

ugcgcacaggugcaggggccgcgggcagcuccucccucugcccucgggcuggggcucaguccuggggaagaagaaacccuca

gcuggggugaugccccugucucagagggagagagugacccuggucuccugaucccucaucacagugacugcacugacucucc

cagggcucagccuucucccuggacagugcccaggcugucucaggagggaaggagagaauuucccugagguaacaacagcugc

ucccuucaguuccccuguagccucugucagccauggccucucccaggccggguucucagcccacugucuguagacacugacu

ccuguccugcugagugugucagcccuuacaccucaggaccagaagucgccuuuaacugaucggagacauggacuacccuaca

cuaggcugauugccucaguuuccugaauuuucaaaagaauacauucucccagaucccucccugucugugggguuuccacccc

uucgacaaccuaauucucucuauuccuauagugguggucacaucagcccuuaugggguacccuggaggaauaucaauagug

gaauuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucu

ucuucuucuucuucuuccuucucucucucucucucucucucucucucucucucucucucucucucucucucucucucucuc

ucuucuucaguuuuugagauaggguuucucuguaugcccuggcuguccuggaacucacuuguagaccaggauggccucgac

cucagaaauccgccugccucugccucccagugcugggauuaaaggcguguggccaccuugcccagccuuucuuauuuucuu

uacuuuuuuuuuuuuuuuuggaggggguaauuuuguuucuagucaucuuuugucuuuugucugcacuggagugauccug

uuucucccugcccuuauauuaucauguguaucagucuccacaggugccagggaaguuaagacaaguuaaaucaggguucuc

uuuaaaggagagauuccugugaacuuagacuguuuccugucagaacuaaacauccagaagccuccugcucuuccucuguccc

acaaguuacagugcuccccccccccccccagugaaucuggacuuggacucugagagacagggucuucugcaauccagggcug

gagugagagggaagaccacacacccugugagcccacuguguugcagugagugcugcacugggguccacagcauacuccaggg

auccugugugacacaccuguaccuugucccccagagucaggggcuggaagucauuuucucuggcugagugucagagguuga

caccauuucugcuacacacucugugauggcugcucacuuggacuggcgguuaugcuaguuagcaagaugaacacagugguu

uacgucucaguugucacacccuuccaguggcauauggcucuaauuucuacuuuugauacgaacucaaacacuuauuaaauua

guuaguuuccauuccaucuuccauucuaguccauucaugcuaaagaacaucacauaaggacugccaggaugacccacuggcu

cauguggauucccucuuagcuucugagucccccagaaaaaugugcagcugaggaaaccagcucugccugcaggucaccagug

ccaugacaguugaagugucaaacagacacauuguucagugucaucagugauuuaacugugccuuguguagauuucagaggg

ucuuguuaauugugguacuuuuuuuuguuuuuuguuuuuuuuuuuuuuuguuuuguuuucaagacaggauuuuucugu

auagcccuggcuguccuggaacucacauuguggaccaggcugaccacgaacucagaaaucugccugccucugccucccgagu

gcugggauuaaaggcgugugccaccaccaaccagcuaaucgugagauuucuuucuuuuuucuuuucuuuucuucuuuuuu

uuuuuuuuuuuguuguuguuguuuuguuuuuugagacaggguucucuguguaucccuggcuguccuugaacucacuuug

uagaccaggcuggccuugaacuuagaaauuugccugccucugcuccggagugcugggauuaaaggcaugugccacuaccaac

cagcuaauugugggauuucuuaaaucuuccacacagauccuccaaaggcacaugugacaugucaccacagaucugacgguga

ugucacccugaggugcugggcccugggcuucuacccugcuaacaucauccugaccuggcaguugaauggggaggagcugac

ccaggacauggagcuuguggagaccaggccuucaggggauggaaccuuccagaagugggcaucugugguggugccucuugg

gaaggagcagaauuacacaugccaugugcaccaugaggggcugccugagccccucacccugagaugggguaaggagggugug

ggugcagagcuggggucagggaaagcuggagccuuuugcagacccugagcugcucagggcugagagcuggggucaugaccu

caccuucauuuccuguaccuguccuucccagagccuccuccauccacugucuccaacauggcgaacguagcuguucugguug

uccuuggagcuuggccaucauugcagcugugguggcuuuugugaugaagagaaggagacacacagguaggaaagggcagag

ucugaguuuucucucagccuccuuuagagugugcucugcucaucaauggggaacacaggcacaccccacauugcuacugucu

guaacugugucugcucucaguucugggaacuuccuagugucaagcucuuccuugaacucucacagcuuuccuucucacagg

uggacaaggaggggacuaugcucuggcuccagguuagugugggggacagaguuguccugaggucauuggagugaagcugg

aguuguugggugcucugggaacccauaauagcuucucuguuguaauccucugguggccugugucagaucuugcuauagau

auaucuuuguauauauuuuucccuaggcagggacagcucccagagcucugauauguuucucucaagauuguaaaggugaca

uucuauggccugauugcagaggggcacuguggacaugguuguuuucagggacucccacaauccccugugaguggugggu

uguugggauauugucuucauuguggugguuccugacccucauucucuaucaugaagacagcugccuggaguggacuuagu

gacagccagugugaccuugggucuucauuuuucuuuagagaacagcgccugauguucccugugagccuaugggcucaaugu

gaagaauuguggagcccagccuucgccuacacaccaggaccugucucuugcauugcccuguguucccuuccaccgccaaccu

uccgggucugcag

108
AW124268
uuuuuuuuuuuuuuuuucagaauaauugcagacaaauuccauuuauuuuucuaaaaaccu

cauuaucuaaaauuuauacagccucacauuccuaaaccaccucuggcacuuuucuugaau

uaagucaaggcguacacagcuccgaaagaaaaauagagauccgguuccaggaagauggcc

augaggacucgcagauaugucuccucggaccuggaagcgugucagccaugggauccacua

auccaccauccgguacacagggucacccacucucaggcucccaagcuucuccaccgagaa

auacaucccaaaaaguggagaugacugguauauacucuucacagaaggaucacacaggcg

auagcucuucagggucuccaguggc

109
AF090738
Sequence below.

cucuagaugaauacacucucaugagggccaccuucucugguaguucaggucgccucugcccauccuucccugcguccucucc

caaaguggccuacaacccuuacccagaggacuauggagacauugagauugguucucacaagaguuccagcaguaaccugggg

gcagaugauggcuacaugcccaugaccccuggggcagcccuuaggagugguggucccaauagcugcaagagcgaugacuaca

ugcccaugagccccacaagcgugucugcucccaagcagauccugcagccacgcuuggcagcggccuugcccccuuccggagc

agccgugccagcacccccuucaggggugggcaggaccuucccaguaaacggagguggcuacaaagccagcuccccagcggag

agcuccccagaagacaguggguacaugcgaaugugguguggcuccaagcugucuauggagaacccagacccuaagcuacucc

ccaacggggacuaccucaacaugucccccagcgaggcaggcacugcagggaccccaccugacuucucagcagcuuugcgugg

aggcagugaaggccucaaaggcaucccgggccacugcuacagcucuuugccccgcucuuauaaggcucccuguuccugcagc

ggagacaaugaccaguaugugcucaugagcuccccugugggccggaucuuggaagaggagagacuggagccccaggccaccc

caggggcuggcaccuuuggggcagcuggugguagucauacccagccucaucacucagcagugccuuccuccaugaggccgag

ugccaucgguggccgcccugagggcuuccugggccagcgaugucgggcagugcggccuacacgccuaucgcuagagggacu

gcagacccuucccagcaugcaagaguacccucuacccacagagcccaagagcccuggcgaguacaucaacauugacuuuggug

aggcagguacccgucugucuccgccugcccccccacuacuggcauccgcggccucaucuucuucacugcucucagcuaguag

uccugcuucaucccuggguucaggaaccccaggcaccagcagcgacagccggcagcgcucuccacucucugacuauaugaacc

uggacuucaguucucccaagucccccaagccuagcacccgcaguggggacacaguaggcuccauggauggccuucucucucc

agaggcuucauccccauacccaccacugcccccacguccuuccacuuccccuuccuccuuacagcagccucugccaccugccc

cgggagaccuauaccgccugccuccagcaucagcugccacuucccagggucccacugcuggcuccucaauguccuccgagcc

uggggauaauggugacuauaccgagauggccuuugguguggcugcaaccccgccacaaccuaucguggcaccuccaaagcca

gaaggugcccgaguggccagucccacaucgggcuugaagcggcuaagucucauggaucagguaucugggguggaggcuuuc

cuucaagucagccagcccccugacccccaccggggugcuaaggucauccgugcagacccacaggggggacgucgucgccacag

uucagagaccuuuuccucuaccaccaccgucaccccaguguccccauccuuugcccacaauuccaagcgccacaauucggccu

cuguggaaaaugucucacucaggaaaagcagugaaggcagcaguacccugggaggaggugaugagccgcccacauccccagg

acaggcacagcccuugguggcugugcccccagugccacaggcuaggccguggaaccccggucagcccggagcuuugauuggc

uguccuggaggcagcaguucucccaugcgcagagagaccuccguggguuuccagaacggccucaacuauaucgccaucgaug

ugagaggcgagcagggguccuuggcgcagucucagccgcagccaggagacaagaacuccuggagccggacccguagccuugg

ggggcuccucggcaccgucggaggcucuggcgccagcggaguguguggggguccaggcacuggagcuuugcccucugccag

caccuaugcaagcaucgacuuccugucccaucacuugaaggaagccacagucgugaaaggugaggcccuuugaccuugagga

ugggggagggagaguggaguauuggguggcu

110
AI834950
uuuuuuuuuuuuuuuuucagcugugaacuauuggauuugagacaggaacagaacaaaucg

acgggccagaggaggguggagagagcacgagugguuuaaauaggggaggaugggagcaug

gcggugggggugggggaagaguuauuuacaagaaggcucagggggccagaggcucaucuu

ggaauauuuuauaacaauauauauaagauucugguuugcuuuuccuuuucgucucguaaa

ggagagagaauugcauaguucgauucuguccaagggggcagcugcauauggucggccggg

cgggucacuggucgu

111
AI851365
uuuuuuuuuuuuuuuuuaagugucaccacuugugacagucagcauguuacuaucagcucc

agccgcagcguuuuuaaggcguuauagauuaggcaggcaauacaaggaacacgauuaaga

aacugacacguaccacacgagcaauuuccagaggcuccucuucugcggugcacacguaac

agugcucuuguugacauucagacaguucugagggccacucugagaggcgccuuccuguuc

ucaccugacaaggauauuguuugguuugguuugguuugguuuugccuuacuauggcuuuu

cuuucaacuacauuuugugucaugcuuguuagcuaacucaaauuuugucuuuguauauuu

acuacuguaaaauuagaauaauuuacuguucaucucauccucugucacugauggaaccua

gagacgccacaagagccacugccgugacauaccucacaagcuacaucccuguccucaaaau

112
AW047339
cggccgcggccaccggccugcgccaagcugcugcugcggcagccaguaccucggugaagc

ccauuuucagucgcgaccugaacgaggccaagcggagggugcgcgagcucuaccgcgcuu

gguaucgggagcgugccgaacaccgugcacuuaaugcagcuggauaucacggugaaacaa

ggacgggauaaaguccgagaaauguucaugaagaaugcccaugucacagaccccagagug

guugaucugcuggucauuaagggaaagauggagcuccaggaaaccaucaaaguauggaag

cagcggacacacguuaugcgguuuuuccaugaaacagaaacaccaaggccaaaggauuuc

uuauccaaguucuauaugg

113
U06834
Sequence below.

gcaccugagcgcgggugccuggcgcgcccgaugggaucguugagaggcccucgacggaaagucccaaacucggaucgcauuc

agccaaagugaggcggcgccauggagcuccgagcgcugcugugcugggcuucccucgccacugcuuuagaagagacccugu

ugaacacaaaacuggaaacggcggaucugaaaugggugacuuacccucaggcagagggccagugggaggagcuaagcggccu

ggaugaggaacagcacagcguccgcaccuaugaggugugcgacaugaagcgucca

gggggccaggcucacuggcugcgcacuggcugggucccaaggcgaggugcuguccacguguaugccacgauacgcuucacca

ugauggaaugccugucccugccgagggccagucgcuccugcaaggagacauucacugucuucuauuacgagagcgaacguga

uacggccacggcccauacgcccgccuggauggagaaccccuacaucaagguggacacaguggccgcagaacaucugacucgga

agcgcccuggagcugaagccacagggaaaguuaauaucaagacgcugcgccug

gguccucucagcaaagcuggcuucuaccuggcuuuccaggaccaaggagccugcauggcucugcucucccugcaucucuuu

uacaagaagugcuccuggcugaucacgaacuugaccuacuuccccgagacggugccucgggagcucguggugccgguggca

gguagcugcguggccaacgcggucccuaccgccaaccccagccccagccucuacugccgggaagauggucaaugggcugagc

agcaggucacgggcugcagcugcgcgccaggguacgaggcugcggaaagcaacaaa

guaugcagagccuguggccagggaaccuucaagccccaaauaggagacgaguccugccugccgugcccagccaacagccacuc

gaauaacauugggucuccugucugccugugucgaauuggguauuaccgggcccgcucagacccccggaguucaccuugcac

uaccccacccucugcuccaagaagcgugguucaccauuugaaugguuccacccugcgccuggaguggagugcuccccuugag

uccggaaggccgagagaccucacuuaugcuguucgcugccgagagugccguccuggggguuccugcuugcccugugggggc

gacaugaccuucgaccccgguccucgagaccugguugagcgcuggguggcaauccgagggcugcguccugaugucaccuau

accuuugagguugcugcuuugaauggugugucuaccuuagccacuggaccaccuccuuuugagccugucaaugucaccacu

gaccgugaggugccuccugcagugucugacauccgagugacucggucgucacccagcagcuugauccugucaugggcuauc

cccagagcacccaguggggccgugcuggacuacgaggucaaguaucaugagaagggcgcagagggccccagcaguguucguu

uccugaagacaucagaaaaccgagcugagcuccgggggcugaagcggggagccagcuaucugguccagguacgcgcacgguc

cgaggcuggcuacggucccuucggccaggagcaucacagucagacucaacuggaugagagcgagagcuggcgggagcagcug

gcccugauugcaggcacugcgguugugggugugguccugguccugguggucgucaucauugcaguucucugccucaggaa

gcagagcaaugggagggaaguugaguacucggauaagcaugggcaguaucucaucgggcacgguaccaaggucuacauuga

uccuuuuacuuacgaagacccuaaugaggcagugagggaauuugccaaagagaucgaugucuccuaugucaagauugaaga

gguaauuggugcaggugaguucggcgaggugugccggggucggcugaaggcaccagggaaaaaggagagcuguguggccau

caagacucugaaggguggcuacaccgagcgccagagggcugaguuccugagcgaggccuccaucaugggccaguucgagcau

cccaacaucauccgccucgagggcguggucaccaacagugugccgguuaugauccucacggaauucauggagaacggagccc

uggacuccuuccugcggcugaacgacgggcaguucacagucauccagcuggugggcaugcugaggggcaucgccucgggca

ugcgguaccuggcugaaaugagcuauguccaccgagaccuggcugcucggaacaucuuggucaacaguaaccuggucugcaa

gguguccgacuuuggccucuccagauucuuggaggagaacuccucugaucccaccuacacaaguucccugggaggcaagauu

cccauccgauggaccgccccugaagccauugccuucaggaaguucaccucugccagugaugccuggcgcuaugggaucguca

ugugggaggucaugucuuuuggggaacggccauacugggacaugagcaaccaggaugugaucaaugccauugaacaggacu

accggcugccuccuccuccagacugccccaccucccuccaccagcucaugcuggacuguuggcagaaggaccggaaugcccgg

ccccgcuuuccccagguggucagcgcucuggacaagaugauccggaaucccgcuagccucaaaaucguggccagggagaaug

gcggggccucacauccacucuuggaccaacggcagccucacuacucugcuuucgguucuguggucgaguggcuucgagcca

ucaagaugggaagauacgaggaaaguuuugcagcggcuggauucggcuccuuugagauggucagucagaucucugccgagg

accuucuccgaauuggagucacucuggcaggacaccagaagaaaaucuuggccagugugcagcauaugaagugggaagcuaa

gccaggagccccuggugggacagggggaccagcccagcaguucugaccuccaaggacucaccaccguggcagauucuucuuu

ccgggaggcagaguuggguggggacucacaagaugagccccucccccucgucacagccuucccauuggauugcacuuugaac

agagggggucggagacacagauuuggggaaccgugccauaugggaucauacaugugcccuccaggcggggaaccccaaacuc

agagugagucuuucccucaagacugggcaaagaaacaucccuacgucucuaaccucccaucuucccagaggcucucuccccaa

gcgccuuccaccucaacgggcaugucccugcagaccaaagagaaagggugaccagccugccaacuugggaguggaaaaugcc

gucccaggaggcaggaaggggcugucaggacccggugauguaaucauuggguuuugauguccugacuugcugucaccacca

aaggcaaucauuuuucccuuguaaaugccccuccccucaucugccuucauauugaagguucugaaguuuuacuguuuuuua

uuuuguuaauuuuuuccuccuuccccccucccuccccuucuuguccagauuuuguguguuaaagggcaccugguuccacua

ucuccuguugggaacaaggacccaucgauauguucuagaacagugccuuggaaaugcca

114
AA980204
ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccgg

agccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagc

cggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgaga

ggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuaga

gacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcga

ggcugagcgggcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgag

cuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggag

ucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguugcg

ugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcug

gagaagagagcagcacaucu

115
AI843232
ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccgg

agccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagc

cggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgaga

ggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuaga

gacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcga

ggcugagcgggcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgag

cuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggag

ucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguugcg

ugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcug

gagaagagagcagcacaucu

116
U59807
Sequence below.

augauguguggcgcgccaucugccacaaugccagccacggccgagacgcaggaggucgccgaccaggugaggcugggcccag

gucaggccagucugagccaggccugcggagacccggcggccucagggaccggccugcccagacuggucagguccugcagcgg

guuuccggggcggccacaagugugacugggagcugggggcucuggaucugguuggaagauucagggccgggaacuggggc

gagucuucugccgcuugcauacaagagggccacucaccuauuagggaacuagccccgggaucgguggagggauccgguggu

cccagagaauucaggaaggcaguguuagaaccuagacggcaccuuuuugacuuacacccaggccuaaacaagagaaagccaga

cugggcuacugugcuugucuccucaaaagaaagagcuaggacuguuuagcucaguggcaggaauucaacugauaccaccacc

accaucaccaacaccgccccucagggaaaaaaaaaaggaucaaaaccagaaguuguagaacuugcuugugccuagucugaaac

gaggggguggaccuugggccugggcugcccuuccugugacuguuagcagagcagagauucaguacaagguagggggagguu

caggguauuagcaagagaagaaaaguuaaacaaauccucucuucagcucuccugccacgccccaagcccaggacccuguccac

uaagccuagcugaucuugggagguguuugcucugaacugaaguggccaagaaggaagugagucagcuccaugagacccuag

aaaugaggaaauguuacagacacacuggccaggcaagggaaccuuggccacgugccacaucagcacucaggaggcagagacag

gcgagucucucugaauuugaagccagcccaguuugcuuaguuccaugccagccauagcuacauagugagacccugucccccc

cccccccaaaaaaaaggagcuguguuguucuuuaucaguggggccaacaguuuaccaugucccccggaaugaggaguauuga

aggcuggcagugugugugugugggggcaccugugcaugaaucuaaguccuuccuucucacccaccauccaggugaaguccc

agcuugaaucgaaagaaaaucagaaguuugaugucuuuaaagccauauccuucaagagacagauaguggcuggcaccaaccu

cuucaucaagguggguacugauaguagcuugccaugaacuggggacauagucucagaguagagcagaguguccugcaacuu

ccugcagagaaccccuuaaggggacauguacauguucugagaggaugaauuugggguguuaggguucccggccuuaaagga

ggagacaaggguuaucacuggcuaaguuaguggcugguggccuguucuggcucaguuucuaaggcuggguuaagccugga

acuggaaccuuaccuuucacucacaugucugucugucugucuuccuccagguugauguugguggagauaaaugcgugcacu

ugaggguguuucaaccccucccccaugaaaacaagccuuugacccugucuuccuaucagaccaacaaagaaaggcacgaugag

cucuccuacuucuga

117
AI152659
gaaaauguuaagagccaucaaauuucuggauauuuugcuaggaaaaugaaauucuacacu

uauuuuuuguagacuuuuuuuaaaugcuguuuacaugaauuguauuuuggaaaaaauauu

auacugugcacccugugaugcaugaagugauuuuauguauggucugcuaugugggcagag

gucaccuuauuccuaugaucuggaauuguuuacuuucuacaaaguaagcuuuguggggau

uuugcuuucauuuucuuuguagcugauguuauuuuaccaggugugcagcaggaauuacac

cacuguguggaauuauaaauacaucccaugugca

118
AI850090
uuuuuuuuuuuuuuuuuccuggugaauauuuuuauuagaggugacaguuucccaggugac

aguuuuucccaaggaagcaaaucucugcgucuauaagggaagaccacagaaccuucacuu

uguaauuuaccuguguaauuuauccaagaacacagcacagcaauugcuuuaugugguacu

cugaccuuaaguaacaaguuguuaacagaaaacacaucaaacaaaaggauaauucucuaa

uuaucaagucagccaucagcuuuucuuaggagagagagagagagugugugugugugugug

ugugugugugugugugugucugucugucugucugucuggguaucccacuuagggccaugu

gcauguuagguaaaugcuccaccacugagcuguuucuuagccgcacuuuucucagauuuc

agguuuguuuguuuguuuguuuguuuuuuaacuaggcaugaaaauaaacuucacuucaaau

119
AF064635
See above sequence (AI850090).

120
AI843106
uuuuuuuuuuuuuuuuuguggaaauuacucuuuauugaaaaauaccaguaauacugacag

acuucaaaaucaauuuacgguuccagaauacaaaguacuuaauacauuuuuuuccaaacc

uguuuguaucucaaaguuagcauuuuuguaaaucaagauacaaauaugauaacuucacua

aaauauuuuccagcuuuauucuuuaaggagcuguauaaccuucaaagucagggucccgag

gucagcagggcauggggcagaaugcaccuggcacucccugugcagcagacugcaaccaca

uu

121
AF033186
auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggg

gaacucuuggcuccagcagcuccuuuugacaagaaaugugguggugagaacuggacgguu

gcuuuugcuccugaugguuccuacuuugcguggucacaaggauaucgcauagugaagcuu

gucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau

ucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccu

gagcacguuauagacuguggagacauagucuggagucuugcuuuugggucuucaguucca

gaaaaacagagucguugcguuaauauagaauggcaucgguuccgauuuggacaggaucag

cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga

aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca

gaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug

aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu

gcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuu

uggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua

gcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucgugug

uaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucg

cccacuccaauauuugcuggaggagcaaaugaccgaugggugagagcugugucuuucagu

caugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaauc

gaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucu

acugauggcaguguuuuagcugcugggacacaugauggaaguguguauuuuugggccacu

ccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugaugucc

acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc

gguuag

122
Z50159
auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggg

gaacucuuggcuccagcagcuccuuuugacaagaaaugugguggugagaacuggacgguu

gcuuuugcuccugaugguuccuacuuugcguggucacaaggauaucgcauagugaagcuu

gucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau

ucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccu

gagcacguuauagacuguggagacauagucuggagucuugcuuuugggucuucaguucca

gaaaaacagagucguugcguuaauauagaauggcaucgguuccgauuuggacaggaucag

cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga

aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca

gaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug

aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu

gcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuu

uggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua

gcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucgugug

uaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucg

cccacuccaauauuugcuggaggagcaaaugaccgaugggugagagcugugucuuucagu

caugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaauc

gaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucu

acugauggcaguguuuuagcugcugggacacaugauggaaguguguauuuuugggccacu

ccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugaugucc

acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc

gguuag

123
X78683
Sequence below.

gaauuccgugugcaaggcgaggucuguaagcuggagcggggcagaggcuggcgggcaccccuuccugaccgcuggugccgc

cgccgccgccuucgggaggaucagacauggcccagaacuugaaggacuuagcuggacgccugcccgccgggccucggggcau

gggcacggcgcugaagcugcugcugggggccggggcgguggccuacggcguccgcgaauccguguucaccguggaaggcgg

ucauagagccaucuuuuuuaaucguauugguggcgugcagcaggacacgauccuggccgaauuucacuucaggauccccug

guuccaguaccccaucaucuaugacauucgggccagaccucggaaaaucuccucccccacaggcuccaaagaccugcagaugg

ugaacaucucccugcgugugcugucccgacccaaugcccaggagcuccccagcauguaccagcgucuagggcuggacuauga

ggagcgagugcugccguccauuguuaaugaggugcucaagagugugguggccaaguucaaugccucgcagcugaucaccca

gcgggcucaggugucccuguugauccgaagagagcugacagagcgcgccaaggacuucagccucauccuggaugauguagc

uaucacagagcugagcuucagccgagaguacacagcugcuguagaagccaagcaaguggcccagcaggaagcccagcgggccc

aguuuuugguggagaaagcgaagcaggaacagcgacagaagauugugcaggcugagggggaggcggaggcugccaagaugc

uuggagaagcacugagcaagaauccuggcuauaucaagcuccgaaagauccgggccgcccagaacaucucuaaaacgaucgcc

acaucacagaaccgaaucuaucucacagcugacaaccuugugcugaaucuacaggaugaaaguuuuacucggggaagugaca

gccucauuaaggguaagaaaugaguguggacaucaagaaccccaccaccagagaaguuggcacacuuguccagcuuggagga

gccagcucggggucaagcacagcccacccugccccaggcaucaugugauggacuuuucuguaucugcccucuuggauuaagg

aagacugagaccagcccuuucagaggcuuuccuccuuccuguguuggcugggaagcgggguggacaaugugauuucuccgu

gauuuccuacagccuugagccucucccagagugggggagauaaccaccaugccaggaauuc

124
X68193
acccaccggcuuucggaccauggccaaccucgagcguaccuucauugccaucaagccaga

uggcgugcagcgcggccuggugggcgagaucaucaaacgguucgagcagaagggguuccg

ccugguggccaugaaguuccuucgggccucugaagaacaccugaagcagcauuacaucga

ccugaaagaccguccuuucuucccggggcuggugaaguacaugaacucggggcccguggu

ggccauggucugggaggggcucaauguggugaaaacgggccgagugaugcugggggagac

caauccagcugauucaaaaccaggcaccauccguggggauuucugcauucaaguuggcag

gaacaucauucauggcagugauucaguggagagugcugagaaagagauccaucugugguu

uaagcccgaagaacugaucgacuacaagucuugugcccaugacuggguguacgaguagac

augaagaaaccagaauccuuuucagcacuacugauggguuucuggacagagcucuucauc

ccacugacaggauggaucaucuuuucuaaaacaauaaagacuuuggaacugaaaaaaaaa

aaaaaaaaaaaa

125
AA062013
uuuugcuuucaacaugacagaugccgcuguguccuucgccaaggacuucuuggccggugg

aguggccgcagcaucuccaagacagcggucacaccaucgagagggucaagcugcugcugc

aggugcacaugccagcaagcaaaucacggcagauaagcaauacaagggcaucauagacug

cgugguucguauccccaaggaacagggagugcucugguccuuugggcgugggaaccgggc

caaugucaucagauacuuccccaccaaggcucucaacuuggccuucaaaguuaauuccaa

gcagaucuuucugggugguguugacaagaggacccaguucuggcgcuacuuuugcaggga

accuggcaucaggugguugccgcuggggcuacauccuugggcuuuguguacccucuugau

uuuugccgguaccgucuagcagcugaugugggcaagcuggagcuaaagggaauucaaggg

ccuugggacugccugguaagacuucaaucugaugggauaagggcuguac

126
AI465965
auccgggacccccacggccccuuugcagcuugccacaagguucugagccccuuggaauac

uuccgccaauguguguaugacaugugugcccauaagggugacaaagccuaucucugccgu

agccuggcugcuuauacugcagccugucaggcagcuggggcagcagugaagcccuggagg

acagacagcgucugcccucuccaguguccugcccacagccacuacuccaucugcacccgc

uccugccagggcuuccugugcugcucucucuggccucacuggcugcaccac

127
U50413
Sequence below.

ggcacgagccgaguuggaggaagcagcggcagcggcagcggcagcgguagcggugaggacggcugugcagccaaggaaccgg

gacagcgaagcgacggcaggucgcagcuggaucgcaggagccugggagcugggagcuucagaggccgcugaagcccaggcug

ggcagaggaaggaagcgagccgacccggaggugaagcugagaguggagcguggcaguaaaaucagacgacagauggacagug

ugacaggaacgucagagaggauugggccucgcugcgagagucagccuggagucaagguguugacaaguugcugagaaggac

acgugggaggacgguggcgcgcggagggagagcccugucuucagucaccccguugauggaggacagauggacagcagccgg

acggccagucaccucucuuaaaccuuuggauagugguccuuugugcucugcuggacaccuguuggggauuuuagcccauuc

ucugaacucacuuucucuuaaaacguaaacucggacggcagugugcgagccagcuccucuguggcagggcacuagagcugca

gacaugagugcagagggcuaccaguacagagcacuguacgacuacaagaaggagcgagaggaagacauugaccuacaccugg

gggacauacugacugugaauaaaggcuccuuaguggcacuuggauucagugauggccaggaagcccggccugaagauauug

gcugguuaaauggcuacaaugaaaccacuggggagaggggagacuuuccaggaacuuacguugaauacauuggaaggaaaag

aauuucacccccuacucccaagccucggcccccucgaccgcuuccuguugcuccggguucuucaaaaacugaagcugacacg

gagcagcaagcguugccccuuccugaccuggccgagcaguuugccccuccugauguugccccgccucuccuuauaaagcucc

uggaagccauugagaagaaaggacuggaauguucgacucuauacagaacacaaagcuccagcaacccugcagaauuacgacag

cuucuugauugugaugccgcgucaguggacuuggagaugaucgacguacacgucuuagcagaugcuuucaaacgcuaucuc

gccgacuuaccaaauccugucauuccuguagcuguuuacaaugagaugaugucuuuagcccaagaacuacagagcccugaag

acugcauccagcuguugaagaagcucauuagauugccuaauauaccucaucaguguuggcuuacgcuucaguauuugcuca

agcauuuuuucaagcucucucaagccuccagcaaaaaccuuuugaaugcaagaguccucucugagauuuucagccccgugcu

uuucagauuuccagccgccagcucugauaauacugaacaccucauaaaagcgauagagauuuuaaucucaacggaauggaau

gagagacagccagcaccagcacugccccccaaaccacccaagcccacuacuguagccaacaacagcaugaacaacaauaugucc

uugcaggaugcugaaugguacuggggagacaucucaagggaagaagugaaugaaaaacuccgagacacugcugaugggaccu

uuuugguacgagacgcaucuacuaaaaugcacggcgauuacacucuuacaccuaggaaaggaggaaauaacaaauuaaucaa

aaucuuucaccgugauggaaaauauggcuucucugauccauuaaccuucaacucugugguugaguuaauaaaccacuaccgg

aaugagucuuuagcucaguacaaccccaagcuggaugugaaguugcucuacccaguguccaaauaccagcaggaucaaguug

ucaaagaagauaauauugaagcuguagggaaaaaauuacaugaauauaauacucaauuucaagaaaaaagucgggaauauga

uagauuauaugaggaguacacccguacuucccaggaaauccaaaugaaaagaacggcuaucgaagcauuuaaugaaaccauaa

aaauauuugaagaacaaugccaaacccaggagcgguacagcaaagaauacauagagaaguuuaaacgcgaaggcaacgagaaa

gaaauucaaaggauuaugcauaaccaugauaagcugaagucgcguaucagugagaucauugacaguaggaggagguuggaa

gaagacuugaagaagcaggcagcugaguaccgagagaucgacaaacgcaugaacaguauuaagccggaccucauccaguuga

gaaagacaagagaccaauacuugauguggcugacgcagaaaggugugcggcagaagaagcugaacgaguggcuggggaauga

aaauaccgaagaucaauacucccugguagaagaugaugaggauuugccccaccaugacgagaagacguggaaugucgggagc

agcaaccgaaacaaagcggagaaccuauugcgagggaagcgagacggcacuuuccuuguccgggagagcaguaagcagggcu

gcuaugccugcuccguagugguagacggcgaagucaagcauugcgucauuaacaagacugccaccggcuauggcuuugccga

gcccuacaaccuguacagcucccugaaggagcuggugcuacauuaucaacacaccucccucgugcagcacaaugacucccuca

augucacacuagcauacccaguauaugcacaacagaggcgaugaagcgcugcccucggauccaguuccucaccuucaagccac

ccaaggccucugagaagcaaagggcuccucuccagcccgaccugugaacugagcugcagaaaugaagccggcugucugcaca

ugggacuagagcuuucuuggacaaaaagaagucggggaagacacgcagccucggacuguuggaugaccagacguuucuaacc

uuauccucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuaauuua

aagccacaacacacaaccaacacacagagagaaagaaaugcaaaaaucucuccgugcagggacaaagaggccuuuaaccauggu

gcuuguuaacgcuuucugaagcuuuaccagcuacaaguugggacuuuggagaccagaagguagacagggccgaagagccug

cgccuggggccgcuugguccagccugguguagccugggugucgcuggguguggugaacccagacacaucacacuguggauu

auuuccuuuuuaaaagagcgaaugauauguaucagagagccgcgucugcucacgcaggacacuuugagagaacauugaugca

gucuguucggaggaaaaaugaaacaccagaaaacguuuuuguuuaaacuuaucaagucagcaaccaacaacccaccaacagaa

aaaaaaaaaaaa

128
AW120502
uuuuuuuuuuuuguuuuaauuuggcuccaaugaucgcauucucaaacuccuuugggaggg

cauuagaugacccaguauccgacgacuuagauucacacguguuuuucuccucugagcucu

uuucuccaggcucacngucuuuguuuuucaagcuuucuugggccuuugaacaauuuucuu

ccuuugaagauucuccugg

129
X62940
Sequence below.

agccgaguaggaccgagcugcugcagacgcgccgggucacucgagccagcaccaccguucucacgcccugagcugcagacagc

uaggcgguuuuaucuaguuugaaccaggcugcuggagcuugcucccucccgcccucucucuuuuuuuuccacggggcuguu

uuuuuaauuuggcugcaauugcaugaaaucccaaugguguagaccaguggcgauggaucuaggaguuuaccaacugagaca

uuuuuccauuucuuucuugucgucuuugcugggaaccgaaaacgcuuccgugagacuugacaauagcucuggugcaagugu

gguagcuaucgacaacaaaauagagcaagcuauggaucuggugaaaagccauuugauguaugcggugagggaggaagugga

aguucugaaggagcagaucaaagaacuaauagagaaaaacucccagcuggagcaggagaacaaucugcugaagacgcuggcca

guccggagcagcucgcccaguuucaggcccagcugcagacuggcuccccuccggccaccacgcagccacaggggaccacacag

cccccugcacagccagcaucccagggcucaggaucaaccgcauagccuccuaggccccaacagaacuggcugcugcugcugcu

gucugaacugaacagaccgaagagaugugcuagagagaagccgccuccacagucacccauuucauugcugucuacgaaagag

acgugagacucacacgcuguucucgcuuucuccccaguauuaagcacucauaagcuuuuggcuugaagaaauguacuaguu

gagugaauuaaagguuaaucagagagugagcagggaugugcccugugcaacguggcagaugucugaggaaugguuuaauug

accccgaggagcucugugccuuuucaacccuccccagccgcccacccugcuucugagagcucgggcggcucgccuucguggg

gcucgccugcgugggguucgaaagugggcugcuccuggauucugcgcucucuucuccuucccuucaaagaacucggagagg

ccagaaacaagacugcaauggggggcggggggagggaugaugcaguccuuauacaaaaccgacaacugucaccaaagcuuau

aaaacacgauaguacugucccucuuuucugaaccaucagaagacacaaaacuguuagugacacaacggugacagguagcugg

gaccuaggcuaucuuauuaugaagguuguuuugcuuguuguauauuuguguauguaguguaacgaauuuguaccauagag

gacuguccguaacuacuguuuagcuucuacacauugaaauguagauguuucauuggcugucugaaaagguguggcuugucc

uuccuagagagaucuacuuaaaaacugcuuuguggcaaaaaccacaccugaagaaauuuuaagaauuuggcccaguuaguca

cucuguguaaucccggaaucuagcugcugaagucuugcgaaguaaacuccccgugaccgaugucaguuaagcuggugauac

cuggagaaguggucaguugcuaaggaaguggauuucccaguagggguuucugcaccucaccuguauagucguucugcgcau

gucccccacacaguccccaccuguauuuaccuguucuacuugucaccuuucaauaaagcauaucaaauguugau

130
U60020
Sequence below.

auggcugcgcacgucuggcuggcggccgcccugcuccuucugguggacuggcugcugcugcggcccaugcucccgggaauc

uucucccuguugguucccgaggugccgcugcuccgggucuggguggugggccugagucgcugggccauccuaggacuagg

gguccgcgggguccucggggucaccgcaggagcccauggcuggcuggcugcuuugcagccgcugguggccgcacugaguuu

ggcccugccuggacuugccuuguuccgagagcuggccgccuggggaacacuccgggagggugacagcgcuggauuacugua

cuggaacagucguccagaugccuucgcuaucaguuauguggcagcauugcccgcagccgcccuguggcacaaguuggggag

ccucugggcgcccagcggcaacagggacgcuggagacaugcugugucggaugcugggcuuccugggcccuaagaagagacg

ucucuaccugguucugguucucuugauucucucuuggcuuggggaaauggccauucccuucuucacgggccgcaucacuga

cuggauucuucaggauaagacaguuccuagcuucacccgcaacauauggcucauguccauucucaccauagccagcacagcg

cuggaguuugcaagugauggaaucuacaacaucaccaugggacacaugcacggccgugugcacagagagguguuucgggcc

guccuucgccaggagacaggguuuuuccugaagaacccagcagguuccaucacaucucgggugacugaggacacagccaacg

ugugcgaguccauuagugacacgcugagccugcugcugugguaccuggggcgagcccugugucucuugguguucauguuu

ugggggucaccguaccucacucuggucacccugaucaaucugccccugcuuuuucuuuugccuaagaagcugggaaaagug

caccagucacuggcagugaaggugcaggagucucuagcaaaguccacgcagguggcccuugaggccuuaucggcgaugccua

ccgugcggagcuuugccaacgaggagggugaggcccagaaguucaggcagaaguuggaagaaaugaagacgcuaaacaagaa

ggaggccuuggcuuacgucgcugaagucuggaccacgagugucucgggaaugcugcugaaggugggaauucuguaccuggg

cgggcagcuggugaucagagggacugucagcagcggcaaccuugucucauucguucucuaccagcuucaguucacccaggcu

guucagguccugcucucccucuaccccuccaugcagaaggcugugggcuccucagagaaaauauucgaauacuuggaccgga

cuccuugcucuccacucaguggcucguuggcacccucaaacaugaaaggccuuguggaguuccaagaugucucuuuugccu

acccaaaccagcccaaaguccaggugcuucaggggcugacguucacccugcauccuggaacggugacagcguuggugggacc

caauggaucagggaagagcaccguggcugcccugcugcagaaccuguaccagcccaccgggggccagcugcugcuggauggc

cagcgccugguccaguaugaucaccauuaccugcacacucagguggccgcagugggacaagagccgcugcuauuuggaagaa

guuuucgagaaaauauugcguauggccugaaccggacuccaaccauggaggaaaucacagcuguggccguggagucuggag

cccacgauuucaucucuggguucccucagggcuaugacacagagguaggugagacugggaaccagcugucaggaggucagc

gacaggcaguggccuuggcccgagccuugauccggaagccacuccugcuuaucuuggaugaugccaccagugcccuggaugc

uggcaaccagcuacggguccagcggcuccuguaugagagccccaagcgggcuucucggacgguucuucuuaucacccagcag

cucagccuggcagagcaggcccaccacauccucuuucucagagaaggcucugucggcgagcagggcacccaccugcagcuca

ugaagagaggagggugcuaccgggccaugguagaggcucuugcggcuccugcagacuga

131
L32752
gaauuccggggccgcucucuccggcaggaucgccgcgauggccgcccagggagagccgca

gguccaguucaaggucguccuggugggcgacggcggcaccggaaagacgacauucaugaa

gcgccacuugaccggagaguuugagaaggaguauguagccacccugggcguggaggugca

cacauuagucuuccauaccaacagaggaccuaucaaguucaaugugugggacacagccgg

ucaggagaaguucggggggcugcgcgauggcuacuacauccaagcccagugugccauuau

aauguuugacguaacaucaagaguuacuuacaagaaugugccuagcuggcauaaagaucu

agugcgugugugugaaaacauccccauuguauuguguggcaacaaaguggauguuaaaga

caugaaagugaaggcaaaaccuauucucuuccaccgaaagaagaaucuucaguacuauga

cauuucugccagaaguaacuacaacuuugaaaagccuuucuucuggcuugccagaaagcu

cauuggagauccuaacuuggaguucguugccaugccugcucuugccccaccugagguagu

cauggacccagcuuuggcagcacaguacgagcaugauuuagagguugcucagacgacugc

ucucccagaugaggaagaugaccugugagaaagugaagcuggagcccugcgucagaaguc

uauuuuaggcaacuguccugugaugccagccagcggugcagugugugugccaccuuauuu

agcuaaaggagaucgugcaauucauugggaugcugaaggagaugaaugggcuucggagug

aauguggcaguuaaaauacaccuucauuuuuuuggacuugcguauuuagcccccuggaac

agaguuguucuggauuucaaagauaagacugcuaccguagcaucacaauagucaguggug

accggaauuc

132
AI840013
uuuuuuuuuuuuuuuuugauuuaugaaaaguuuuauuuaucaguacugugaagaauucuc

aucauaauugcuacguuaaucaaggaaaaggcacagagaagcaugugucguuugaguccu

cgauacuggaccucccagcccaugcucccuaugaggagucuagcugcugugguggucuuc

acagcuuugguuuucuggagacgaagcucaugauugcguucaugcacuccucugacagcc

accuugcuugcagaguagugcacucuucagcguugacugcguagagcuuuucuuucucau

uuuuucugauuaacucuuuggaaauucucauuggguuuggcgggagcuucgcauau

133
AB020424
ucgggaaucgauugagagaccgcgaaccuguaaacggaugauaccgagucgggcaggcgu

uaugccagcccaacucgggaccucgcaucauguccgcggcuaccuuagaguguuucggga

augauuugcgguggaugaacgaaaccccgguacguccugugccaaggagcauaugucagg

acggacgcucguuaaugccucagugguggggcaacguucgcucucuaucuauacgacucu

cgacaauggauaucucggcucucgcaucgaugaagaacguagcgaaaugcgauacuuggu

gugaauugcagaauccugugaaccaucgagucuuugaacgcaaguugcgcccgaggccuu

ucgguugagggcacgccugccugggcgucacgccuuguuuugcucugugcccgugcucuu

ucgggggcggucauggaugcggagauuggcccuccgugccucgugugcggcgggcuuaag

cgcggggugucggcgucgggaagggcacgacgagugguggacggagcaccagcaggaugu

uguggucccccgucaccuuaaggggcucaagagacccggacuaggcgagccgcgcuucgu

aagaggagggcgagcugucucgcaau

134
AI848453
uuuuuuuuuuuuuuuuugaaguugcugccccuuuauuggugacccgggcaaguuuaagga

gaacaacauuaaagcacacaaaguguauccaugucaccagcucaaccaggaggagugagg

gucacggcaggguucucccaugguguaagaaaucaacgcaauuucaucacaccccguuac

uuuccaaguuaacgaaccgauaagaaaagauucucccuuaaacugacaaguacaauguac

auguacaugauuuuggaauaauuuaauacuuuaaccucaagauacaacuauauucuaaga

ccauuauuuuaaaggaacggauccuuacaaaaccaaaauaacccauauagcacgagguug

guuuagccuuucuucuucuuucaacaaacgugcaccacauguuucaguagcaaggccgau

gccauggauaugagagcugugauuugcagggaccaaccacaucuagaaccggggaggcca

aucanacgguggguu

135
AU040563
cccuuggaggauaguuuuauugacaagucgaguuagguuuuagaguaaacuuuuaucacc

ccagucaggccccuucccaggggaggcucgcugguagcucagauggccuugguggugggc

agauuguuguaguugucuuccuggcccuccagcaggcuucgggagguggcuaucuccugc

uccagccuggacuugauguccaguagcugcuuauacuccggguucuggcgcucuaugugc

ggcacgcaggugcngcg

136
X89749
Sequence below.

ggacugacuccuugggcagauugccucuccuccuucucaugccagaggcugcugaugaggaaagguccaggggacugucca

ugcugucuucauccucagagucacugccugaugcugcaacaagacccuucuuguuuagcaauagugguuggaacacucucu

uguaaguuaccggagcacuaguauaggaggaggaucaucgacuacccucccgccacuccacggcugcuggcuccuagaaacc

ccagcuucaccucucacugggacucgaguuccagaaugaaaagcaagaagggucuuguugcagcaucaggcagugacucuga

ggaugaagacagcauggacaguccccuggaccuuuccucaucagcagccucuggcaugagaaggaggagaggcaaucugccc

aaggagucaguccagauucugcgagacuggcuguaugaacacagauacaacgccuaucccucagagcaagagaaagcacugc

ugucccagcagacacaccuguccacacuacaggucuguaacugguucaucaacgcccgccgcaggcuccuuccugacaugcu

gagaaaggauggcaaagauccaaaucaguucacgauuucccgccguggggccaagauuucagaagcuagcucuauugaagcu

gcaauggguaucaaaaacuucaugccaacucuagaagagagcccauuucauuccugcguaguuggacccaacccaacccuag

ggagaccagugucucccaaaccucccuccccaggauccauuuuggcucgcccgucagugaucugccauaccacugugacugc

auugaaggaugggccuuucucucucugucagccgauuggugugggacagaguacagauguaccgcaaauagcacccagcaac

uuuacagacaccucucucguguacccagaggacacuugcaaaucuggacccaguccaaacccucagaguggucuuuucaaca

cuccucccccuacuccaccagaccucaaccaggauuuuaguggauuccagcuucuaguggauguugcacucaaacgagcggc

agagauggagcuucaggccaaacucacagcuuaaccguuuuuucaaacaaaacaguucuccaaaauacgguccugauugccg

ggggugauggcaagagaugcauuauuuuauauauuuuuuc

137
AW125390
uuuuuuuuuuuuuuuuuggugguuaucaagugcacuuuauugaauccacuguggauagau

aaaugaguguuacaccugcguguagggaggggcaaggagggacgcagcugcggaggguga

agcacuucaggaccggaagucggaauccucuauuaagugugaagguuuugagcguuaaga

acaaugaugaugacacuaacaauggugauaacaaccaucaggaugcugaggaccaaggug

cugauguucaggcacuuagcaguggaggcguaggccugggcuccagucacaucacccacc

aucuuccgaucccuagacuucacggaguaggcauaggcuaugaagcccaggcagcagaag

uucaugaagaguguauugaacagggaccagaccacauggucaggcaccgacaccucucug

ggcauguugaucacaguaguucugacagaagccga

138
X05862
Sequence below.

aagcuucaggauacagugcacacucguaaauaaaaacuacaggcugcugcgaauuauauuucaacugaccggagaggcaaag

ccugacuguccauuaacccuuaacuuccaaacgcaaacugcuuacugcaucuuuuggcauuuuaccuuaugccuuguuagg

uccaaggcaagagaagcgucaucaauaaccacgcaugugcaacagcuuuuccagaggaaagguguggguggcucuuaaaaga

gccuuugaguuaggagugugaguuaaacgagcucacuuggagcugguguacuuggugacugccuuggugcccuccgacacc

gcgugcuuggccagcuccccgggcagcagcaggcgcacggccgucuggaucucccgggacgugauggucgagcgcuuguug

uaaugcgccaggcgggaagccucgcucgcgaugcgcucgaagaugucguucacgaacgaguucaugaugcccauggccuug

gaggagaugccggugucggggugcacuugcuucagcaccuuguacacguacaccgaguagcucuccuugcggcugcgcuug

cgcuucuugccguccuucuucugggccuuggugacggccuucuuggagcccuucuucggggcgggagcggacuuggcggg

cucaggcauacugagaggaugaagugaacuaaguugaaaaaggauaacuaaaaguuaaugacuguucuggcugcaauuuuaa

acaaacuuacggcuauggcaaccugaaucaccauacgucauguacuaacaguccaaucaaaacaagggauuuucaaaccaggg

cgccauugguaaccaauguguaaccaaugaaaucucuccguuuucgcguccagccuugacuauauauacuaugcguauacgu

uuuugcuucuuacugcggugguuaucuacagcugaguuaugucuggacguggcaagcaaggacguggcaagcaaggaggca

aggcccgcgccaaggccaagacgcgcuccucccgggccggccugcaguuccccgugggccgcgugcaccggcugcuccgcaa

gggcaacuacucggagcgcgugggcgccggcgccccgguguaccuggcggccgugcuggaguaccugacggccgagauccu

ggagcuggcgggcaacgcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccugcagcuggccauccgcaacgacg

aggagcucaacaagcugcugggccgcgugaccaucgcgcagggcggcguccugcccaacauccaggccgugcugcugcccaa

gaagaccgagagccaccacaaggccaaggggaagugaaaccaaacauuacgaaucaccaaggcucuuuucagagccacucacu

uucucaaagagaccuaacacuacugggauagugcauugugggaaauacguguauuaaccuuccuccuauuuucccugcuug

ugguuaguucaaccccuaagccuuaggcuaagaguauauugguuuuuggaaggcaggcacccaaccucggaccuaguacaua

aaacagacacaucuugaacuccaggccagccuacucugcaggacgaguuccaggacagaccggacugcacaaagaauugucuu

gaaauguuccuuuaucagcacauaugcugauaaacaacuaaucacuguacaaucaauccucacuugaauccuguuuaugugg

caugauugacaaguccugccauuuggcaaagucaaaaucagcaaaggauguuaaagcauuuggugguaucacagcuaaaac

139
AW046181
uuuuuuuuuuuuuuuaugcaaauaguuuucaagauuuuauugcaaaccaaaauugguuua

ucgcacacaaaaaaaguugugugguaaggaggaggaauuguacaggauuauaacccaugu

uaauuacaguacauuaaaaugaugguuuacaaauaagccuguaaguuuaaauaucuagug

uuauaacccaauguacagacuuccuuuacacgauacauacaauaaucaggaaugcaaaag

aauaugaacaaagggaaaaaaaacauaaauaaugcccguuuuauaggugacauuuuaaac

aauugaaaacaccaaccggcuuugacugacaacuggggcauugguccauaaaaacccuuu

cuaaaaauagaaauau

140
U10118
Sequence below.

gaggcugcucaagagcugcgguugggucaccgcuucauguuucucugccgauucuggggaaagauggcaacgaaugaugcu

guucugaagaggcuggagcagaagggugcagaggcggaucagaucaucgaauaucucaagcagcagguugcucuucuuaag

gagaaagcaauuuugcaggcaacaaugagagaagaaaagaaacuucgaguugaaaaugcuaaacugaaaaaagaaauagaaga

gcuaaagcaagagcugauucuggcagaaauucauaacggaguggagcaagugcguguucgauugaguacuccacugcagacg

aacuguacugcuucugaaaguguggugcagucuccaucaguagcaaccaccgccucuccugcuacaaaagagcagaucaaag

cgggagaagaaaagaaggugaaagagaagacugaaaagaaaggagagaaaaaggagaagcagcagucggcagcagcaaguacu

gacuccaagccuaucgacgcaucgcgucuggaucuucgaauugguuguauuguuacugccaagaagcacccugaugcagau

ucacuguauguggaggaaguagaugugggagaagcagccccgcgcacggucgucagcgggcuggugaaucauguuccucua

gaacagaugcaaaaucguauggugguuuuacucuguaaucugaagccugcaaagaugcggggaguucugucucaagccaug

gugaugugugccaguucaccagagaaaguggagauucuggccccucccaacggguccguuccuggggacagaauuacuuuu

gaugcuuuuccuggagagccugacaaggagcuaaacccuaagaagaagaucugggagcagauccagccugaccugcacacca

augcugaguguguggccacauacaaaggagcucccuuugaggugaaggggaagggaguuugcagagcccaaaccauggccaa

uaguggaauuaaauaagugcucuguaacugaaagacauuggcgaaaacuuaauaacaauaaagagaaguguguuuaucacuu

acauau

141
AW212775
ggccuuguuuuugguuugcaauaaagaguauuucuuuaaaaggcacauuuuguuaaauag

gcaguuccccuccugccucuuccuuuguagcaguguacugcauccuagaaacauuuagca

aagcagcccuuagccuccccgacccccuuucccucccucccagca

142
AI846302
uuuuuuuuuuuuuuuuuaaacaaugacgccguuuauuuaaaauguuuacucccagaaaua

uagauauaaaaaaaaaaauaagacaauuaacagcacuaaaccaggcaccuucaaccgaau

cccaccauccucguuaacucccuuccuguuacccuuuguagaugaccagaagauuucagg

agccccuggacagccagagugguuccugcccagggcuucccgccuuccuccuguccuaga

gcuucccgugggaaagcuugggugagaauuuuagccuaaagggagggggcuguggccggg

cacuuugcgcucauccacugcagg

143
M22998
Sequence below.

acaggguacaguugugcgucagggcguggaggucuggcgggagacgcauaguuacagcgcguccguucuccgucucgcagc

cggcacagcuagagcuucgagcgcagcgcggccauggaucccagcagcaagaaggugacgggccgccucauguuggcugugg

gaggagcagugcucggaucacugcaguucggcuauaacacuggugucaucaacgccccccagaagguuauugaggaguucua

caaucaaacauggaaccaccgcuacggagagcccaucccauccaccacacucaccacgcuuuggucucucuccguggccaucu

ucucugucgggggcaugauugguuccuucucugucggccucuuuguuaaucgcuuuggcaggcggaacuccaugcugaug

augaaccuguuggccuuuguggcugcugugcuuaugggcuucuccaaacugggcaaguccuuugagaugcugauccuggg

ccgcuucaucaucgguguguacugcggccugacuacuggcuuugugcccauguaugugggagaggugucaccuacagcucu

acguggagcccuaggcacacugcaccagcugggaaucgucguuggcauccuuauugcccagguguuuggcuuagacuccau

caugggcaaugcagacuuguggccucugcugcucagugucaucuucaucccagcccugcuacaguguauccuguugcccuu

cugccccgagagcccccgcuuccugcucaucaaucguaacgaggagaaccgggccaagagugugcugaagaagcuucgaggg

acagccgaugugacccgagaccugcaggagaugaaagaagagggucggcagaugaugcgggagaagaaggucaccaucuugg

agcuguuccgcucacccgccuaccgccagcccauccucaucgcuguggugcugcagcugucccagcagcugucggguaucaa

ugcuguguucuacuacucaacgagcaucuucgagaaggcaggugugcagcagccuguguacgccaccaucggcuccgguauc

gucaacacggccuucacuguggugucgcuguuuguuguagagcgagcuggacgacggacccugcaccucauuggccuggcu

ggcauggcaggcugugcugugcucaugaccaucgcccuggccuugcuggaacggcugccuuggauguccuaucugagcauc

guggccaucuuuggcuuuguggccuucuuugaaguaggcccugguccuauuccaugguucauuguggccgagcuguucag

ccaggggccccguccugcugcuauugcuguggcuggcuucuccaacuggaccucaaacuucauugugggcaugugcuucca

guauguggagcaacugugcggccccuacgucuucaucaucuucacggugcuccucgugcucuucuucaucuucaccuacuu

caaagucccugagaccaaaggccgaaccuucgaugagaucgcuuccggcuuccggcaggggggugccagccaaagugacaag

acacccgaggagcucuuccacccucugggggcggacucccaagugugaggagccccacacccagcccggccugcucccugcag

cccaaggaucucucuggagcacaggcagcuagaugagaccucuuccgaaccgacagaucucgggcaagccgggccugggcgc

cuuuccucagccagcagugaaguccaggaggauauucaggacuuugauggcuccagaauuuuuaaugaaagcaagacugcu

gcucagaucuauucagauaagcagcagguuuuauaauuuuuuuauuacugauuuuguuauuuuuuuuuuuuaucagccac

ucuccuaucuccacacuguagucuucaccuugauuggcccagugccugaggguggggaccacgcccuguccagacacuugcc

uucuuugccaagcuaaucuguagggcuggaccuauggccaaggacacacuaauaccgaacucugagcuaggaggcuuuacgc

uggaggcgguagcugccacccacuuccgcaggccuggaccucggcaccauagggguccggacuccauuuuaggauucgccca

uuccugucucuuccuacccaaccacucaauuaaucuuuccuugccugagaccaguuggaagcacuggagugcagggaggaga

gggaagggccaggcugggcugccagguucuagucuccugugcacugagggccacacaaacaccaugagaaggaccucggagg

cugagaacuuaacugcugaagacacggacacuccugcccugcuguguauagauggaagauauuuauauauuuuuugguugu

caauauuaaauacagacacuaaguuauaguauaucuggacaaacccacuuguaaauacaccaacaaacuccuguaacuuuacc

uaagcagauauaaau

ggcugguuuuuag

144
X64837
Sequence below.

gcuuucuaaacuagcaagcaucguguggguccuucaggagugggagugcagacagaccugacagcguccgcuaagcgacacu

gacuguacuuccacuccugaaggacccacacgaugcuuucuaaacuagcaagucugcagaccauugcugcucugcgccgagg

aguccacaccucagucgccucugccacgucuguugccacaaagaagacagagcaaggcccaccauccuccgaguacauuuuug

aacgggaaucuaaauauggugcacacaauuaccauccuuugccuguagcccuggagagaggaaaaggcauuuauauguggga

uguggaaggcaggcaguacuucgauuuccugagugcuuauggugcugucagccaaggacacugccacccaaagaucauagau

gccaugaagagucagguggacaagcugacauuaacaucucgggcuuucuauaacaauguccuuggugaauacgaggaguaca

ucaccaagcuuuucaacuacaacaaaguucucccuaugaauacaggaguggaggcuggagagacugcauguaagcucgcucg

ucguuggggcuacaccgugaaaggcauccagaaauacaaagcaaagauuguuuuugcugaugggaacuuuuggggucgaac

acuaucugcaaucuccaguuccacagauccgaccaguuaugauggcuuuggacccuucaugccaggcuuugaaaccauccca

uauaacgaucugcccgcacuggagcgugcucuucaggauccaaauguugcugccuucaugguggagcccauccagggugaa

gcaggcguuaucguuccggauccaggauaccugacaggaguucgggaacucugcaccaggcaccagguccuguuuauugcu

gaugaaauacagacaggauuggccagaacugguagauggcuggcuguggaucaugagaaugucagaccugauaugguucuu

cuugggaaggcccuuucuggcgguuuauacccugugucugcagugcugugugacgaugagauaaugcugaccauuaaacca

ggcgagcacggcuccacauacggcggaaacccacuaggcugccgaauugccauugcggcucuugagguuuuagaagaggaga

aucuugcugagaaugcagacaagaugggcgcuauccugaggaaggagcucaugaagcugcccucugacguugugaccucag

ugagagggaaaggguugcuaaaugccauugucaucagagaaaccaaagacugugaugcuuggaaggugugccugcgacuuc

gagauaacgggcuucuggccaagccaacccacggugauaucaucaggcuugccccuccccuugugaucaaggaggaugagau

ccgggaguccguggagaucaucaacaagacuaucuuguccuucugagaguaggaacucuggggagccaucuucagacagggc

ucuugugaaacucugcuugcaguggccagagccugucuccugaaaggcauauauuucaguugaugcauaauagagugacac

cuaggaaccugcagguggcugcgugacagaaaagugagagcgagaggcgaggcgucucuuuguugagguuugacugugugg

gaacuuucuaaggagaaacggacccaucugcguacagccugcagauggaggccugcagucauuuacgugcgucuuuacaguu

uccuugcugaugugaaugguuuguauuuagaaguuauuucugagauacuacagaacaguuaaaucauuauaaucaaugaau

guuaaguugauugaagguuaagcauauguaaaauacuaguuuaaaguaaacuuuucauuggccaacaccagaauguauuau

auagauucugagaauucauuacuaaauuacacuuugcuugauugcaauuuguaaaacauuuauuuucaguauuucuuugaa

uaaagcuuaauguuucuuuuuacgccaacagaguauuuuguauuuccauuuugguaauaaucaguguauuauuucauccu

gaugacuggcauuucaucaccuauugagaucacuggguguguuucaggccuuuuauucuaaauaaagcuaugaccaguuuc

ugucugu

145
AI843119
uuuuuuuuuuuucuuuuccgacgcccacaagaggaauaagagauuuaaugauggaaagua

uggggaaaucacaguuuucagacaugaguaaucaaaaacuugacauuuuucuugauaucc

aaaucuagaugucuguaucaaaccagaggugauggccuuggggauggcagugaagacugu

uaggaccauuagaucagau

146
AI837786
uuuuuuuuuuuuuuuuuacaguuuuaaaacaauacacagcuuucucgggcugaagcaauu

gcaagaacguauugguauugguauauuacagcuacauacaagguuuaugaauagcaaugg

agaaaaauaaguuauuuaaauauugacuucauaaagagaaagugcaauguuguuaguugu

cauaucacuugcuugacaguuugugggguuucuucccuaucaauuuuaacaaucaagaua

acauggacucaagacagaauuuuucgggaaccucacucaguccucacacagcagugacuu

gggaaucuacguguguuccaccgcaguugugaaacacacuacuccguguccaggacucau

uucucagagaagaaucaauucgaguuccauccacaccuggggucgggacaca

147
U41465
Sequence below.

ccgggcucgaauucucuagacucgaguuuagagaauucgagcucucccaguuuuaaagcaaaauuuuggacugugaagcaa

ggcacugggcaaacacaacauggccuccccggcugacagcuguauccaguuuacccggcacgcuagugauguucuucucaac

cuuaaucgccuccggagucgggacaucuugacggacguugucaucguggugagccgugagcaguuuagagcccauaagaca

gugcucauggccugcagcggccuguucuacaguaucuucacugaccaguugaaaugcaaccuuaguguaaucaaucuagauc

cugaaaucagcccugagggguuuugcauccuccuggacuucauguacacaucuaggcucaaccugagggaaggcaauaucau

ggcggugaugaccacagccauguaccugcagauggagcauguugucgacacaugcaggaaguucaucaaggccagugaagca

gaaauggccccugcacuuaaaccuccccgugaagaguuccugaacagccggaugcugaugccccaugacaucauggccuacc

gaggucgugaggucguggagaacaauaugccacugagaaauacucccgggugugagagcagagcuuuugcuccuccucugu

acaguggccugucaacaccaccagccucuuaucccauguacagccaucucccgcucagcaccuuccucuucucugaugagga

gcuccgagaugccccccgaaugccuguggccaacccuuuucccaaggagcgugcccuccccugcgacagugccaggcaaguc

ccuaaugaguauagcaggccagccauggaggugucccccaguuugugucacagcaacaucuacucgcccaaggaggcagucc

cagaggaggcucggagugacauacacuacagugugccugagggccccaagccugcugucccuucugcucggaaugcuccaua

cuuccccugugacaaagccagcaaagaagaagagagaccuucuucggaggaugagauugcccugcauuucgagccccccaau

gcacccuugaaccggaagggucugguuaguccccagaguccccagaaauccgacugccagcccaacucacccacagaguccug

cagcagcaagaacgccugcauccuucaggccucuggcucuccgccagccaagagccccacugacccgaaagccugcaacugga

agaaguauaaguucaucguucucaacagccucaaucagaaugccaaacccgagggcucugagcaggcagagcugggucgccu

cuccccucgagccuacccugcaccgcccgcuugccagccgccuauggagcccgcgaaccuugaucuccaguccccgaccaagc

ucagugccaguggggaggacucuaccaucccccaagccagccggcucaauaaucucgugaacaggucccugggaggcucccc

ccgaagcagcagugagagucacucaccacucuacaugcaccccccaaagugcacauccugcggcucucaguccccacagcaua

cagagaugugccuccauacugcugggcccacguucccggaggagaugggggaaacccagucagaguauucggauucuagcu

gugagaaugggaccuucuucugcaacgaaugugacugccguuucucugaggaggccucgcucaagaggcacacgcugcagac

gcacagugacaaaccauacaaaugugaucgcugccaggccuccuuccgcuacaagggcaaccucgccagccacaagacugucc

acacgggugagaaacccuaucgcuguaacauuuguggagcgcaguucaaucggccagccaaccugaagacccacacucgaau

ucacucuggagaaaagcccuacaaaugugaaaccuguggggccagguuuguucagguggcccaccuccgugcccacgugcuc

auccacacuggagagaagccguaccccugugaaaucuguggcacucgcuuccggcaccuucagacucugaagagccaucugc

gcauccacacaggagagaaaccuuaccauugugagaaguguaaccugcacuuucgucacaaaagccaacugcgacuucauuu

gcgccagaagcacggcgccaucaccaacaccaaggugcaauaccgcgugucggccgcugaccugccuccggagcuccccaaag

ccugcugaaugaagcauggaguguuccucgcccuuuccucuccagccccuucucagaaucuacccaaaggaugcuguaacac

uuuauacaaaggucaucccaugauguagugccucucucauccacuagugcaaaucauaguugggguggggguggg

148
U70494
ucgcgguccgacggaggagugggcgcugggaucucgcugagcguccgccuggccucgucu

cuuccucgcucgucggagcuucagcacgguccgagauggcuggcgguaaggcuggaaagg

acuccggaaaggccaagacaaaggcgguuucccgcucgcagcgagccggcuugcaguucc

cugugggccguauucaucgacaccugaaaucuaggacaaccagccacggacgugugggcg

cgaccgccgcuguguacagcgcagccauccuggaguaccucaccgcagagguacuugagu

uggcaggaaaugcgucaaaagacuuaaagguaaagcguaucaccccucgucacuugcagc

uugcuauacguggagaugaagaauuggauucucugaucaaagcuaccauugcugguggug

gugucaucccacacauccacaaaucgcugaucgggaagaaaggacaacagaagacuguuu

aaggaugccuggauuccuuauuaucucaggacucuaaauauuccuaacagcuguccagug

uuggugauuccaguggacuguaucucugugaaaaacacaauuuugccuuuuuguaauucu

auuugagcaaguuggaggcuuaauuagccuuccaaccaaccaaauuucugcauucgaguc

uuaaccauauuuaaguguuacuguggcuucaaagaagcuauugauucugaaguagugggu

uuugauugaguugacuguuuuuaaaaaacuguuuggauuuuaauugugaugcagaaguua

uaguaacaagcauuugguuuuguacagacauuguuuccacucugguggauaagcucaaua

aaggucauaucccaaacuagcuuuaaacuugcuuaauaaucgggucuuaccuuagaucuc

acucagcaacaaguacauucucugcuuacuaauuaaacagugcaucuguagucauaaaaa

aaaaaaaaaaaaaaaaaaaaaaaaaaaaa

149
D17666
Sequence below.

caccaccgugcacgcagcuccgggcccgugggguguugguucuugcccucguaacccccucuguccagccaccaugauaagc

gccagcagagccgcggccgcgcgucucgugggcaccgcugcgucccggagccccgcagccgcccguccccaggugagaagcu

gccaugccuuccggugggggcuccaggcccggacucgagugaggcaggccuugccuucgggucagacucuaggaaaaauccg

gagcgaagggauguaacggaccuucugugggcauuguuggccuucuugcagggcuuuagcuucgaacugugcugagucaca

auccuuggcguuccuaagucuuuaccccgcuaauugagacgucuguccccccucuaaccugugcgcuuugaaugugccugg

acuuaggcaguggacguaguuuacuggaaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnuuuuacauacuaaggacuaaagcuug

cauguguuccucagaauaugaaaagcccaaguucuuguguaguugauggcugaugcaacuuuuuuccccccaggauggcug

gaauggccuuagccaugaggcuuuuagauuuguuucaagaagagauuaugcguaaguacaaccucaguuucucugagaaaa

aaaaaaaacacuuauugaaccucaaagcuuggauggguugggugcguuauacauuuguacuuguaguuuauucaauaugcc

acugguaacaccaacauaaaacacaguucuucguauuggagaccacuguucagaugaccauggaauuucauuucuuacagau

cagaagcaaucaagggugcagugguugguauugauuuggguacuacuaacuccuguguggcuguuauggagggcaaacaag

caaaggugagcaugauuggaaaccugaggucacuuagauacccagucuggcauuaaguacauaggaaugcugagucggagcc

cagguuaguggugggcacuuuaauccuaguaaaggcagagggaucucugaguucaggaccagccuagaguacaaagugagn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn

nnnnnnnnnnnnnnnnnnnnnnnacuuuaaucagugucuuugggaauuuuagguccuggagaaugcugaaggugccaga

acuaccccuucugugguugccuuuacagcagauggagaacgacuuguugguaugccagcaaaacggcaagcugucaccaauc

caaacaauaccuucuaugcuacuaagcgucuuauuggacgacgauaugaugacccugaaguacagaaagacacgugaguaau

aggaaaaucaguccagaagacuggugcuuugaucaaaguucuguggauaccuugaguucuguggaucaccuuggaucacuu

uuucauuauuucugcuugggaagaaaucacaccaccaucagaggcauauagguuuuuuuuuuguuauuucuuuguuguug

uuguuuuccuauuuauuuguuuguuuguuuggggggggguuucuuuguguauuuuccuggaacucauucuguagaccag

gcuggnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnucaugugauauaugaugaacuuagagugguuaaguuucacagggauaguu

uacuuacauaaucuuucugucuuuaaguaagaauguuccuuuuaaaauuguccgugccuccaauggugaugcuuggguuga

ggcucauggaaaacucuauucuccaagucagauuggagcauuuguguugaugaagaugaaagagacugcagguaaguggau

uuauuucacauuuaggaaaauuggaaugugcuguuuauuucucugcauuaauacugauuaacuucauauucuguagauaau

ggagucugaagcuunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngaauucaugcuccuccugcugccuccugggugcuaaguugca

aggugauagcucagguacucacucuagugucuuucuuggggugcucuuuuccaaggccucucuacauauuaagccacaaag

gagucuguugccccucaagaggaugagauguggaauauuaggcuacaguuuuguugccuuuuuuuuauuuuccuaacaug

guaccacaauugaauuuuauucuuuguuucccagaaaauuacuugggccacacagcaaaaaaugcugugaucacagucccug

cuuauuucaaugauucacagcgacagguaaaauuagaucucuuguuugcugggaguggaggugggguaccugaguuaaagg

auggaaagauagauuuauuucuacuuucucuaggccacuaaggaugcuggccagauaucugggcuaaaugugcuucgagug

aucaaugagccuacagcugcugcucuagcuuacggucuggacaaaucugaagauaaaguguaaguuggucagaugacguagc

auuaccugcauuuacagggguuguguguguguguguguguguguaauuuuacuacaauuuguguggguccguguguugu

gguacauuuguacauuuguacauggcauggauauggaugucaaagauunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnaaaccagu

aguugguguguuacuaauuuuacuuguuucuguaugacaugcuuauaugauacguuaacaggcaugccacuuagguugau

aacuacauucaguuauuaaguauuucaggaaauaucauaguuaauaauuaaacuuuuggucuuuuaauucguuccuuuguu

uuguuccuuggaacuuaacuuacuuauuuauuuuuuagcauugcuguguaugauuuaggugguggaaccuuugacauuuc

uauccuggaaauucagaaaggaguguuugaggugaaaucuaccaauggggacacuuucuuaggaggggaagacuuugacca

agcuuuguugcggcacauugucaaggaguucaagagagagguuaguuaccacugcuuagucaccacugguuaagguguagg

cguuggguuguugagaauuuuuguuuguuugcauugcuuuuagcuuuguuaauagcuuuuuuauacuaagguaacuaac

uauacuucagauucauggguaaacuaaaccaguuuaguuauauaaucuuagauugggaacaaaagaccaagugacaguguua

uaguagggagaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnacuacucucucgcagucuauauaugucuccuaauccuauuuau

agacagggguugauuugaccaaagacaacauggcgcuucagaggguucgggaagcugcugagaaggcuaaaugugaacuuu

ccucaucugugcaggugagggauggaaaaaucccaguacugagcauauuugaauaguguauucuaauuuaccuaaugucag

uguagcucuuuacaguuuucuguuggcugaaaacuuggggcaugagcaaaggaacaacuugaugaucaguucuuuucauuu

gaaugaaugaaguagauuuauggauguguguaucuuuugccugcaugugugucuguacuacauuugugcuugguuucugu

ggcggccagaagaggguaucagaacugacaugucaguguuggggannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncacacugaguc

uaaauucugaucaugucuuucagucguguuauguuacuuugagugaguaucaaagaucacgucucccaucugacguguggu

ccugugcagacugacaucaacuugccauaccuuaccauggaugcuucuggaccaaagcauuugaauaugaagcugacucgag

cucaguuugaaggcauugucacagaucuaaucaagagaacuauugcuccgugucagaaagcuaugcaggaugcagaagucag

caagagugacauaggagaagugauucugguugguggcaugacaaggaugcccaagguauggacucaugguauuucuccuag

aggaaaaaaauaacaaugcauucuugaggcaaauggcuuguguuguguguggaaacaaaugugauccauucuucuaguguu

cuuuaaagaguggugagaccagacucaccaaaaagugcuuuuagucgccugugauggcucauguaggaggauggccuugag

uucuggguaagaugcagcuacagaauucuaccuugcacacacacuuaaacccagucugguaaagagaaguuguuaagcuunn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn

nnnnnnnnnnnnnnnnnnnnnncagauguaaaauugauaauacuucuuccuaagauugggcugauuguguagaauaugaga

acuguauuuuauaaccccuugucaugugccuucuauuucaaaugauauccucugggaagcuagauaauuaaauucuucucu

cauuuaaguggacaguggaugagaugcucugaaguugucaaauacaaacaagucugcagucuuggauaugaaucucucuga

cuugcugucuggcaggcguauucuguuuggcuccaucagucgcccuggguguuggcuaacagguucuuucucccugaugc

uuagguucagcagacuguacaagaucuuuuuggcagagccccgaguaaagcuguuaauccugaugaggcuguagccaucgg

agcugccauccagggagguguguuggcuggugacguuacagacgugcugcuccuggaugucacuccccucucucuggguau

ugagacucugggaggcgucuuuaccaaacuuauuaauaggaacaccacuauuccaaccaaaaagagccagguaagagccauu

cuuuuuuccugccuauuaacagucccaaguuguacaagugcuguuuacaaucacuuuaugaacucuuuaaaacuuuguuuc

uaagacuauacuaacuggacugggugnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnccuagguguuuucuacugcugcugauggac

aaacucaaguagagauuaaagugugucagggggaacgagagauggcuggagacaacaaacuucuaggacaguucacuuuggu

aaguguuuuugagucugaguaucaugcuuuuggggucuauagcuugcaaagcuccaaacugcugacauuacaggcauauug

uguuauuuuuuaaaaagaacguuauguacaugaguuaugaaacccaugauuuuaguuuuuuaccuaaagugcuuuguguu

uucagaauuugaaauuuucaaagccugggaaauguucagacucagaagcaaugcuaacucagaaguuaguuuuauccugau

uacucauuuuaaaaaacuuaauagcuacugguucuggucagcauugcuacaguagagaaguuuauuugcuguaaauucugg

gcacauauaaccaucaugguuauuaacuucuugaagcccagugauuucagaaagcacuaaaacuaccaccaucacuuaaaauc

ucaagguuuugaacauucagugaagauacuuguuuuaggaaacaagugguuaguuggccugauuuggaaaugagaauacau

gggccuuucaaaggagcucacucuggauauuuauuuuagauuggaauucccccagccccucguggagugccccagauugaa

guuacauuugacauugaugccaaugggauugugcacguuucugccaaagauaaaggcacuggucgugagcaacaga

150
X14897
Sequence below.

auaaauucuuauuuugacacucaccaaaauagucaccuggaaaacccgcuuuuugugacaaaguacagaaggcuuggucaca

uuuaaaucacugagaacuagagagaaauacuaucgcaaacuguaauagacauuacauccauaaaaguuuccccaguccuuau

uguaauauugcacagugcaauugcuacauggcaaacuaguguagcauagaagucaaagcaaaaacaaaccaaagaaaggagcc

acaagaguaaaacuguucaacaguuaauaguucaaacuaagccauugaaucuaucauugggaucguuaaaaugaaucuuccu

acaccuugcaguguaugauuuaacuuuuacagaacacaagccaaguuuaaaaucagcaguagagauauuaaaaugaaaaggu

uugcuaauagaguaacauuaaauacccugaaggaaaaaaaaccuaaauaucaaaauaacugauuaaaauucacuugcaaauua

gcacacgaauaugcaacuuggaaaucaugcaguguuuuauuuaagaaaacauaaaacaaaacuauuaaaauaguuuuagagg

ggguaaaauccagguccucugccaggaugcuaaaauuagacuucaggggaauuuugaagucuucaauuuugaaaccuauua

aaaagcccaugauuacaguuaauuaagagcagugcacgcaacagugacacgccuuuagagagcauuacuguguaugaacaug

uuggcugcuaccagccacagucaauuuaacaaggcugcucagucaugaacuuaauacagagagagcacgccuaggcagcaag

cacagcuugcugggccacuuuccucccugucgugacacaaucaauccguguacuugguguaucugaagcgcacgcugcaccg

cggcacugcccggcggguuucugggcggggagcgauccccgcgucgccccccgugaaaccgacagagccuggacuuucagga

gguacagcggcggucugaaggggaucugggaucuugcagagggaacuugcaucgaaacuugggcaguucuccgaaccggag

acuaagcuuccccgagcagcgcacuuuggagacguguccggucuacuccggacucgcaucucauuccacucggccauagccu

uggcuucccggcgaccucagcguggucacaggggccccccugugcccagggaaauguuucaagcuuuucccggagacuacga

cuccggcucccgguguagcucaucacccuccgccgagucucaguaccugucuucgguggacuccuucggcaguccacccacc

gccgccgccucccaggagugcgccggucucggggaaaugcccggcuccuucgugccaacggucaccgcaaucacaaccagcca

ggaucuucaguggcucgugcaacccacccucaucucuuccauggcccagucccaggggcagccacuggccucccagccucca

gcuguugacccuuaugacaugccaggaaccagcuacucaaccccaggccugagugccuacagcacuggcggggcaagcggaa

guggugggccuucaaccagcacaaccaccaguggaccugugucugcccguccagccagagccaggccuagaagaccccgagaa

gagacacuuaccccagaagaagaagaaaagcgaaggguucgcagagagcggaacaagcuggcugcagcuaagugcaggaaccg

ucggagggagcugacagaucgacuucaggcggaaacugaucagcuugaagaggaaaaggcagagcuggagucggagaucgcc

gagcugcaaaaagagaaggaacgccuggaguuuguccugguggcccacaaaccgggcugcaagauccccuacgaagaggggc

cggggccaggcccgcuggccgaggugagagauuugccagggucaacauccgcuaaggaagacggcuucggcuggcugcugc

cgcccccuccaccacccccccugcccuuccagagcagccgagacgcaccccccaaccugacggcuucucucuuuacacacagug

aaguucaaguccucggcgaccccuuccccguuguuagcccuucguacacuuccucguuuguccucaccugcccggaggucuc

cgcguucgccggcgcccaacgcaccagcggcagcgagcagccguccgacccgcugaacucgcccucccuucuugcucuguaaa

cucuuuagacaaacaaaacaaacaaacccgcaaggaacaaggaggaggaagaugaggaggagaggggaggaagcaguccgggg

guguguguguggacccuuugacucuucugucugaccaccugccgccucugccaucggacaugacggaaggaccuccuuugu

guuuugugcuccgucucugguuuucugugccccggcgagaccggagagcuggugacuuuggggacaggggguggggcggg

gauggacaccccuccugcauaucuuuguccuguuacuucaacccaacuucuggggauagauggcuggcuggguggguaggg

uggggugcaacgcccaccuuuggcgucuugcgugaggcuggaggggaaagggugcugaguguggggugcaggguggguug

aggucgagcuggcaugcaccuccagagagacccaacgaggaaaugacagcaccguccuguccuucuuuucccccacccaccca

uccacccucaagggugcagggugaccaagauagcucuguuuugcucccucgggccuuagcugauuaacuuaacauuuccaag

agguuacaaccuccuccuggacgaauugagcccccgacugagggaagucgaugcccccuuugggagucugcuaaccccacuu

cccgcugauuccaaaaugugaaccccuaucugacugcucagucuuucccuccugggaaaacuggcucagguuggauuuuuu

uccucgucugcuacagagcccccucccaacucaggcccgcucccaccccugugcaguauuaugcuaugucccucucacccuca

cccccaccccaggcgcccuuggccguccucguugggccuuacugguuuugggcagcagggggcgcugcgacgcccaucuug

cuggagcgcuuuauacugugaaugaguggucggauugcugggugcgccggaugggauugacccccagcccuccaaaacuuu

cccugggccuccccuucuuccacuugcuuccucccuccccuugacagggaguuagacucgaaaggaugaccacgacgcaucc

cgguggccuucuugcucaggccccagacuuuuucucuuuaaguccuucgccuuccccagccuaggacgccaacuucucccca

cccugggagccccgcauccucucacagaggucgaggcaauuuucagagaaguuuucagggcugaggcuuuggcuccccuauc

cucgauauuugaauccccaaauauuuuuggacuagcauacuuaagagggggcugaguucccacuaucccacuccauccaauu

ccuucagucccaaagacgaguucugucccuucccuccagcuuucaccucgugagaaucccacgagucagauuucuauuuuuu

aauauuggggagaugggcccuaccgcccgucccccgugcugcauggaacauuccauacccuguccugggcccuagguuccaa

accuaaucccaaaccccacccccagcuauuuaucccuuuccugguucccaaaaagcacuuauaucuauuauguauaaauaaau

auauuauauaugagugugcgugugugugcgugugcgugcgugcgugcgugcgugcgagcuuccuuguuuucaagugugc

uguggaguucaaaaucgcuucuggggauuugagucagacuuucuggcugucccuuuuugucaccuuuuuguuguugucuc

ggcuccucuggcuguuggagacagucccggccucucccuuuauccuuucucaagucugucucgcucagaccacuuccaacau

gucuccacucucaaugacucugaucuccggunugucuguuaauucuggauuugucggggacaugcaauuuuacuucuguaa

guaagugugacugggugguagauuuuuuacaaucuauaucguugagaauuc

151
AJ006289
Sequence below.

caccugauucccggaggcccgagcccuuagucugggcgggguggcgcgggccggaaggacgccaucccggccugggccaugg

aggcucccgcaccgucccucacggaggaggauuugacugaagugaagaaggacgcuuuagagaauuuacguguuuaccugu

gugagaaaaucauagcugagagacauuuugaucaucuacgugcaaaaaaaauacuaaguagagaagacacugaagaaauuuc

uugccgaacuucaaguagaaaacgggcugggaaguuguuagacuacuuacaggagaaccccaggggccuggacacccuggug

gaauccauccgcagggagaaaacacagagcuuccugauucagaagauaacggaugaggugcuaaagcuucggaauauaaaac

uggagcaccucaaaggccugaagugcagcagcugugagcccuuugcagccggagccaccaacaaccucucuaggugcaauuc

cgaugagagcaaucucucugagaaacagagagcauccacugucauguaccacccggagggagaguccagcacggcucccuuc

uucucuauggcgucgucccugaacuugccaguccuggaaguuggcaggacugaaaacagcagcuucucuucagccacucuuc

cucgaccuggggacccuggggcucccccuuugcccccagaccuucgguuggaagaggggggaaguuguggaaacucaagug

agauguuucuccccuuacggucacgggcucuuucacgccaaugauacaucaccgccuaguuguuuuacuagugaugcaaaau

gcugugaaggaggccaucuuucuauacaaaccacggugacaggucacucacauucgaugcgugccuuuaaaaucaguguaca

cauucucuguaaauaggauuuguuaggguaaagaagcgcucuggggcggcgugguguaaucaugguggucgugacuuuuc

cauaauguccuuucuuuuuuauuauuuuuagguguuugcguauuuugaacuuuucauaagauuaauuuuaucggaauauu

ucucaauuugagaaaacaacuuguggauugggaauaauguuuuuagcacauuuaugcuacaaauuuucagucugauuguuu

uucccacugaucuggcaguauauuuuagcaguaagcuguugugugucaggaaagcuggacacgggaaagcugccgacacac

ucagcagugucccacuccuuaguucugagaagccgucggguucugaggagacaccugguggcacugagccuggugaccuca

gugggccaaaauuuguuuuauacucacccugccagcgugagugucuuacuuucacaggccuuguguccucagucuuaucuu

aaaggauguuaucuuggcagggcaucacuuguaauuaauggaugauacuuguaauugacuaaaguccucgcucugagccgu

uuguucuggcuccgagagcgcugacaugugaagcauggugagcagcgagggaacugacaggauguggccguggccagugug

gcuuuaguguuugcaucaggcagccaccagcuccauccguguucuuacugcuuuacaaaguuugacuaacuuuacacauuu

uaaaaaugcugauugucuucguuuaaauuauaauuuuaccuauuucuugacaucuaacuccuauuuauuucuauuauuuaa

aaauuaagaaaugaaaauuugcuauuaacaauaaaguuuuuuuaaugu

152
X12944
Sequence below.

ggggggggggggucagcgccgacguccccugccgccaccaugcccaaaagaaaggcugaaggggaugcuaaaggagacaaaa

ccaaggugaaggacgagccacagagaagaucugcaagguugucugcuaaaccugcuccuccaaagccagagcccaaaccuaaa

aaggccccugcgaagaagggagagaagguacccaaggggaagaaggggaaagcugacgccgggaaggaugcgaauaauccug

cagaaaauggagaugccaaaacagaccaggcacagaaagcugaaggugcuggagaugccaagugaugugugugcauuuuuga

uaacuguguacuucuggugacuguacaguuugaaauacuauuuuuuaucaaguuuuauaaaaaugcagaauuucguuuuac

uuuuuuuuuuuuuuuaagcuauauuguuagcacacagaacacuucauuacugggugggggaaggaucaugugucaguaac

aaaaucucucccaagcuggauugaggacagaaaaccucuuucccugauaauuuuggaaggcuccuguuggcucccaggagag

agauccuggucuugaccuagguggccaccaaggcacaacaaugccuuguggucugggaaaacuauaaauucacuuuuauauc

cucuucccccuguacuaucaacauagacuuaauucccuuaaaaaccagagaccuguuggaaccuggcccccaaaauugguuu

cccaguccauugagugauggggacuuugcagugacuucauugaguguucucaaaagagcacugguuccuuuuauaaaagau

uguggaucuucagauugauaauucugccuaaaagucagggucggcuugugaaaaguuguuaaaacaacauccuuaauguga

aaugucaacccucacucuaagcuacuucccccuuuucaaagcauugaaugaagacuucauuggguuuuauaguggcuuucu

gauuuugguagucauaucagaagggaauuuggaaguucuuguauauuguugcauugucugcccauguccugccugaauacc

augauuguuuaugaaagaaucuuaauaaagcugguuacaguuaggcuggaaaa

153
AW061302
uuuuuuuuuuuuuuuuuggaaguccauaaguaguuuauugucuucaagacuacagugugg

auuccucucccagagaagggucuuucagaggcaggggacugucacccaggugcaggccgu

cuacuugucauuuucauacauggcuggauucuuccuuuucgacugcucaaacuccugguu

gccccauguguagaucagguagaccacuacaaacggcggcgccacgcgcaggaugcgcuc

gcgagugcggcgcaacacguuggggaugccuuugcugaaauagcuugggaaggcgcgcug

cucaaagggcgacaagcugua

154
U67328
Sequence below.

caugaagccagagauguggaagaugugucuagacugcaucaaugaacugauggauacguuggaugcacauuccaacaucucu

gucggagagaacauuuuggcagagagugagaacuuacacaacuuugaucaguucacuccguguacgacgcugcauccuaacu

uugguggagcgaauggaugaagaauuuaccaaaauaaugcaaaauacugauccucacucccaagaguauguggagcaccuga

aggaugaggcacaagugugugcaucauugagcgagugcagcgcuaccuggaggagaaagguaccacugaggagaucugccag

aucuacuuaaggcgcauccugcacacguacuacaaguuugacuacaaggcccaucagcggcacguuacuccuccugaaggau

ccucaaagucugagcaagaccaggcagaaaaugagggugaggacucagcugugcuaauggaaagacugugcaaguacaucua

ugccaaggaccguacagaccggauccguaccugugccauccucugccauaucuaccaucaugcgcuccacucccgcugguau

caggcccgugaccucaugcucaugagccaccuacaggacaacauucagcacgcagacccgccggugcagauccuguauaaccg

uacuauggugcaacugggcaucugugcuuuccgccaaggccugacaaaggaugcacacaauggcacuucuggauauucaguc

aagugguggugccaaggagcuucuaggucaggguuugcugcugcgcgcuugcaggagcgaaaucaggaacaggaaaaggua

gagcgacgccggcaggugcccuuucaccugcacaucaaccuggagcugcuggagugugucuaucuggugucagcuaugcuc

cuggagauccccuacauggcugcccaugagagcgaugcccgccgacgcaunaucagcaagcaguuccaccaccaacugcggg

ugggcgagcggcacgcccugcuagguccucccgagucaaugagggagcauguggucgcugccuccaaggccaugaagaugg

gcgacuggaagaccugccacaguuucaucauuaaugaaaagaugaaugggaaagugugggaccuuuucccugaggcugacaa

aguucgcaccaugcuaguucggaagauccaggaagagucucugaggaccuaccuuuuuaccuacagcagugucuaugacuca

aucaguauggagacacuaucagauauguuugagcuggaucuacccacuguucacuccaucaucagcaagaugaucauuaacg

aagaauugauggcuucccuggaccagccgacacagacuguggugaugcaccguacugagcccucugcccagcaagaaacuug

gcucugcaagcuggcugagaaaacuuggcacccuaguggagaauaauggacggguguuugaccaaaaacagggaaccuaugg

uggcuauuuccgagaccccaaggguggcuaccggaaaaauggaggcuaaaugccccgugguggcuacccccagcaacagucu

cagacaaccuccugaguuccccacuucagucacccuguggacagaccaucuaaccuuuuucuccuaacucaccccaaucauua

aagaucuuuugaggaauuaaaaaaaaagaaagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

155
AI604314
uuauuaauuaaaaaacaauuuauugaaaaagaguagugcuuuguacaaauucccauugca

gcccccagauaucaacugaucucuuuccagcuuugguaguaggguauaaaaauaucaaaa

cuagguaaguucugauguaagauuucuaugggauuauuuuagaauauauagauuugugua

guuuggcaaguaucauuucuaugcauuuacauuacauauuaagcacagauucuguggcaa

aacaucuuugcaugauuacuuuacacacacaaauauaguaaaacuuacauaguacaaauu

cacauaagacuccauucugucuauaacuucauccaugugguuuuaccaugaauuauaauu

cuuaaccucuccuauaacugucagcuuccauuuaauuuugaaaguaucacuucacaaaga

gcacuucauuugcuuuuagaguauacauagacu

156
AI845121
cggccgccaagaaguauaacaugcgaguggaagacuacgagccauaccccgaugauggca

ugggguauggcgacuacccgaugcuccccaaccgaucacagcaugagagggauccguggu

aucagugggaccacucagaacucaggaugaacuggggugaaccgauacacugggaccuag

acauguacaucaggaaucguguggacacgucaccuaccccuguguccugngaugucaugu

guaaacaucucuucggcuuuguggcuuucaugguuuucauguucuggguagggcacgugu

ucccuuccuaccagccuguggguccgaagcaguacccuuacaaaaaucuguaccuggagcg

157
AW047756
uuuuuuuuuuuuuuuuugaugcaaaugucuuuauuuuccacuuaaacaaguuucccuuuu

gcacuggccuguggcacaaaacagauggcuggguggugacauuaacugucaaguuaguga

gaugcagagauggugagacacugcauuugagugcauaauacuuuuauuccagaggaacgc

caugcagcccaguuacaccuuuaggucagaaaggcugaugcgugaccagccucuauugcc

ucccuugguaagaaggacccacaagugcagaguccaacagaugcuggcucugagcugaac

ucagggcauuccaauuaccacuuucuucuucaccuacacagggccugcucagauguccuu

uuuacaacuccauaagcccuuuggccaaagucccugcaguguuuggggaggaccuuccca

cccuucaccagucagugucugaucugguggag

158
AI838021
uuuuuuuuuuuuuuuuuaauaucuguaauaguuuauuucaaagauuugacauuuacaagu

agaggcaccacaugcuaucugacaguaaaauacugcagggacugaaggccaaggagagag

auccacagaagacaggccuguagugcaggcauugcaucgaccuugcccacagugcuuugu

ucccaacucaggacaguacuuuagugcuugcuucauuuacuggaaaaguucacuggacau

aguuuccacuucuucccccacagcuuccagcucagcaaacuuaagcuacuacuccucgau

gcucucauagaggcucuugauuugugucuggaagaacuuggcaagcucuacucguuuggc

uuucagugucggugucagaaguccguuuucaa

159
AW122893
uuuuuuuuuuuuuuuuucugagguauuaaaauaucuagacugaauuuugccaaauguaag

agggagaaaguuccugaagacucugacuacuugcuuauuuuugauugaccuucuaugcuu

augucauuacugccucacaacguguuugauguccuuuaaugauacaaagugagccugugc

cuucauuuucuugcccauuuugguaccccucgugccg

160
M59821
Sequence below.

gcgcccgaacgucuagcagaguaccugcugcuguaagcuugucgucugggcugcaccgcccgucuuaacccauucucgacuu

aacuacucucgucgaacaagcauggaaguacagaaagaagcgcagcgcaucaugacucugucgguauggaagauguaccacu

cucgcaugcagcgagguggcuugcgacuccaccggagucugcagcuaucccucguuaugcgcagcgcucgagagcucuaccu

cucagccaagguagaagcccaccagcccgaguucccgccaucccgcagggcucuugacccucgccugcacccgccgcgggaag

ccgaaguugcaguggaaguagcgucccccgaagccgugcagccuccggagcccauggauacgcaagaggaagugcugcgagu

ccaggagaccccugcgcucugugacccgccccccgcuagagucagccgcaagcgccggagcagcagcgauuugagcgacagua

gugaugccggacugguaccaagcaagaaggcccgucuagaagagguggagggggaggcgacgucggagguucccgaucgcc

ugcagcuuccuccggcacaaagcgaaggugccuucccuaaccucgcccgcguccuccaaaggcgcuucuccagucuccugaac

uguggacccgccgugcccccgccgacgccccccacgugcgaggccaagccagccugccgcccggccgacaauaugcucaacgu

gcuggugcgagcugugguggccuucugagagcucugguggcuucuuucgagcggcgccaccggagcggagaacgcacaccc

gaggcgaaggccggcgggggccgugaagaagagccgcggcccgagcugccgagaggccagggcaaggacugaggagcgaggg

gcgcgggcgccuucucccagacgugcguccauaggugcuauuaaaggacugucccuuccuuggcuuggagaagggacaccu

agaucuugaaucucagggucgaacucucuaggggccaggcugcccuuucaaggccguuucacuaccauucgcguuucggcc

ccuacaagugggcacgcuugugcaagcggucagaguugcgucaugggacagacgcgggugcuuccuguugccuugcguggg

uguggggccugggaggaggccaggguguggacccgcccuagggacugggaagugacuugagucaccucgcccccacaggcu

gcugugggugagccugaacugaaccaaucaaaucugcgcagaguugaaguggcuggagaccccgggacuggucaaccuagau

gaucgccuggcguggaccaccgcgggacgggugggccgcuggucguaguugcugccguagacacagcuucuucgggcagga

aagaaaauuuuuuuuuuaccagcguguuuaagaaagucuguuuacuuuucccacgguggguuguuuaauuagcaacuaccu

ggaguuuuacaaugucagcuaggaaaauaaagaccaucggugu

161
M13805
See above (same Accession Number).

162
AI845886
uuuuuuuuuuuuuuuuugguuccacuuaaguugcauguuuuauuucucccaaucccagca

auagcacagaagcccaucauguccaucccagacugguuucuaguaggcugagaugacagg

gagccucaguaacgcuaauggcacagagggcucccaaaugccaggcacaacugugccucc

acacuggugacugcccagagugcccuggccccaguguguuggcacucagucugacuuuac

aacgcaaccugcaccuuugaaagggacagucugggaguggggagugugagggagugaagc

ucaaacugccuccugucagcucacccuuucaacauuaaacagagaccaagagagaaacag

uuccaauauuucacauauauuucuucuugugcagucuaagccgagaaugccauguaaaug

ggucacugcgaaaugcagcaauuuagu

163
X53157
gucucgggcgagauggcuucaagguuacuucgcggagugggcgcuuuggcggcgcaggcc

cugaggcgcacggcccguggcgcggccgugacccgcuccauggcuucuggaggugguguc

cccacugaugaggagcaggcuacugggcuggagagggagaucaugauagcagcacagaag

ggacuggacccauacaauaugcuaccuccaaaggcagcuucaggcaccaaggaagacccu

aaucuagucccguccaucagcaacaagagaauagugggcugcaucugugaagaggacaac

uguacugucaucugguuuuggcugcacaaaggcgagagucagcgaugccccaacugugga

acccauuacaagcuggugccccaccaaauggcccacugagccccuguguuaucuuuucag

aauguaaagaaaaacuucucucuaauaaagacuagccauugcaccugcuccuccc

164
U19118
See above (same Accession Number).

165
AF062071
Sequence below.

gcgcaccgccygyguygcgcgscagcgucgucuaggugcaucgcgggcccccgcagrwagaaaaauauggcucaggagacua

accagaccccagggcccaugcuguguaguacaggauguggcuuuuaugggaauccuaggacaaauggaauguguucuguuu

gcuacaaagaacaucuucagagacagcagaauaguggcagaaugagcccaauggggacagcuagugguuccaacaguccuac

cucagauucugcaucuguacagagagcagaugcugguuuaaacaacugugaaggugcugcuggcagcacaucugaaaaauca

agaaaugugccuguggcugccuugccuguaacucaacaaaugacagaaaugagcauuucaagagaggacaaaauaacuacccc

gaaaacagaggugucagagccaguugucacucagcccaguccaucaguuucucagcccaguucuucucaaagugaagaaaaa

gcuccugaguugcccaaaccaaagaagaacagauguuuuauguguagaaagaaaguuggccuuacaggguuugacugccgau

guggaaauuuguuuuguggacuucaccguuacucugacaagcacaacuguccauaugauuacaaagcagaagcugcagcaaa

aaucagaaaagaaaauccaguuguuguggcugaaaaaauccagagaauauaaaauuacuacaugugaagagacugaaacuuu

guuuuuauuuuaauauaucguaggaaaacauuaaagagcagaugcauggccauuuuccuuugauguucuccagaguuuugc

uuuauacuugucugucauauaauugaucuuuuaggauguuuggguguuuguuacaggcagaauuggauagauacagcccu

acaaauguauaugcccuccccucaguaaaauuggacaaaaauaugcacaacaaauugaaauacacauauacuaggaacaaaau

uuaguuccacgugccaaacuaaaggaaugaaaucucugcauguuugcagcauaucugccuuuugggaauguaaucaaggua

uaaucuuuggcuaguguuaugugccuguacuuaaaaaaaaaaaaaugguacaccagaaaaggacuggcagucuacuaccaua

gucaaacuucaccuuaauuucgacaugacuuuuggaagcaggaagaaagcuacaaaacugguauuugguaccaugugugagc

cugguuaaauuggucuucuaaaagcugucaauuaggacauucugcgaaagguaacaucacaacugguucuaagucaaaccau

caagucaacagcagggugccugagauaaucuuggaagcuuauugugcuggccugcaccagaagauaucugcauucucauuac

uaaaauuguagcacagaacugcacuaggauuuguuuacaaggagaaauuaaacucuguuugguuuucacauauagcagcuc

uguuaaauaacaugcaucugaauuuuaaguugcaaagguaucugaacaguuaauuuuucaugugcaucuuuuguugaaugu

uuugguucaagaaagaauguuuaaagcuuuuuaaagacuucaguucuuaauguaacuguacccuucugcauggaaaaucau

aaccaacauggcugcaguagacuucuuuagugguauccagcaccacuugcagagggcugcuuuaucauauuguacuugggu

guaggacucuaguguucuuggguguauugcaugggcugcauuaucuacagcauuguacaauaacaacuagaaaaggcggua

uacuucacugaugcuugucugguaauaucacuucuguguuaaaauggaagguuuuuugugauguaugaaacuuguguuuu

uuauauauaaaugaguauaguuagauuaguguugugguaaugccuguuuucaucuguaaauaguuaaguauguacacaaca

aggcacuacuucugauuuuugcaguguucaguccuaguuuuucuuuauuaaaacauugaguuuugcuucaauuuuaugua

ccuuaguucuaaguuagauuugcagauguguacagauaguucauauuuauguauugcacauaaucaugcuauucagcauug

augcuauauuguauuauguaaauaauaaaagcaguguacagagggaaaa

166
U10404
augacagaugccgcuguguccuucgccaaggacuucuuggccgguggaguggccgcagcc

aucuccaagacagcgguagcacccaucgagagggucaagcugcugcugcaggugcagcau

gccagcaagcaaaucacggcagauaagcaauacaagggcaucauagacugcgugguucgu

auccccaaggaacagggaguccuguccuucuggcgugggaaccuggccaaugucaucaga

uacuuccccacccaggcucucaacuuugccuucaaagauaaauacaagcagaucuuucug

ggugguguggacaagaggacccaguucuggcgcuacuuugcagggaaccuggcaucaggu

ggugccgcuggggcuacauccuugugcuuuguguacccucuugauuuugcccguacccgu

cuagcagcugaugugggcaaagcuggagcugaaagggaauucaaaggccuuggugacugc

cugguuaagaucuacaaaucugaugggauuaagggccuguaccaaggcuuuaauguguca

guacagggcauuaucaucuaccgagcugccuacuuugguaucuaugacacugcaaaggga

augcucccagaucccaagaauacucacaucuucaucagcuggaugauugcacagucuguc

acugcugucgcuggccugacuuccuauccuuuugacacgguucgccgucguaugaugaug

cagucuggacgcaaaggaacugauaucauguacacaggcacgcuugacugcuggcggaag

aucgcgcgcgaugaagggagcaaggcuuuuuucaagggcgcaugguccaacguucucaga

ggcauggguggcgccuuugugcuugucuuguaugaugagaucaagaaauacacauaa

167
U07634
Sequence below.

cguagaaguugucucugucggcgggcgggcgggcaggauuggggcaccgagaccggcgugcggacagcagggaucgcgggg

agcgaggggugcggcauggagcuccgggcagucgguuucugccuggcgcugcugugggguugcgcgcuggcggccgcggc

ggcacagggaaaggaaguuguuuuguuggacuucgcagcaaugaagggagagcucggcuggcucacgcaccccuauggcaaa

gggugggaccugaugcagaacaucauggacgacaugccuaucuacauguacucggugugcaacgugguauccggcgaccag

gacaacuggcuccgcaccaacuggguguaccgggaggaggccgagcgcaucuuuauugagcucaaguucacggugcgagacu

guaacagcuucccggguggcgcccaugccugcaaagagaccuucaaccucuacuaugcagagucagauguggacuauggcac

caacuuccagaagcgccaguucaccaagauugacaccaucgccccugacgagaucacggucagcagugacuucgaggcucgca

acgucaagcugaacguagaggagcgcaugguggggccccuuacccggaagggcuucuaccuggccuuccaggacaucggcgc

cugcgugcggcugcucuccguucgcgucuacuacaagaagugucccgagaugcugcagagcuuggccugcuuccccgagacc

auugcugucgcuguuuccgauacacaaccccuggccacgguggccgguaccugcguggaccaugccguggugccuuauggg

ggcgagggggcucucaugcacugcacgguggauggcgaguggcuggugccauccgagugccugugccaggaaggcuacgag

aaggucgaggaugccugccgagccuguucuccaggauucuucaagucugaggcaucugagagcccuucccuggagugucca

gagcauacccugccauccacagagggugccaccuccugccagugugaagaaggcuauuucagggcaccugaggacccacugu

ccaugucuugcacacguccacccucugccccuaacuaccucacggcaugcaugggugccaaaguagaacugcguuggacagc

ucccaaggacacugguggccgccaggacauugucuacagugucacuugugaacagugcugcgcagagucuggcgagugugg

gcccugugaggccacggugcgcuauucagaaccuccucacgcccugacccgcacgagugugacagucagugaccuggagccc

cacaugaacuauaccuucgcugucgaagcacgcaauggcgucucaggccuggugacuagccgaagcuuccggacugccagcg

ucaguauuaaccaaacagagccccccaaagugaggcuggaggaccgaagcaccaccucccugagugucaccaggagcaucccg

gugucacagcagagccguguguggaaguacgaagucaccuaccgcaagaagggggaugccaacagcuauaauggccgccgca

cggaaggcuucuccgugacccuggaugaccuugcuccggauaccacguaccuggugcaggugcaggcauggacgcaggagg

gccaaggagccggcagcaaagugcacgaguuccagacgcuguccacggaaggaucucgcaacauggcggugaucggcggugu

ggcuguagguguuguuuugcuucugguacuggcaggaguuggccucuucauccaucgaaggaggaggaaccugcgggcuc

gccaguccucugaggauguccguuuuuccaagucagaacaacuaaagccccugaagaccuauguggauccucacacuuacga

agaccccaaccaggcuguacucaaguuuaccaccgagauccacccauccuguguggcaaggcagaaggucauuggagcagga

gaguuuggagaggucuauaaagggacgcugaaggcauccucggggaagaaggagauaccgguggccaucaagacacugaaag

cgggcuacacugagaagcagcggguggacuuccugagcgaggccagcaucaugggccaguuuagccaccacaauaucauccg

ccuggaggcgguggucucuaaauacaaacccaugaugauuaucacagaguacauggagaauggagcgcuagacaaguuccuu

agggagaaggauggugaguucagcguacuucaguuggugggcaugcugagggguaucgcauccggcaugaaguaccuggcc

aacaugaacuacgugcacagagaccuggcugcccgcaacauccucgucaacagcaaccuggugugcaagguguccgauuuug

gccugucgcgugugcuggaggaugaccccgaggccaccuacaccacaaguggcggcaagaucccuauucgauggacagcccc

agaggccauuuccuaccgcaaguucaccucagccagcgauguguggagcuacggcauugucaugugggaagugaugacuua

uggcgaacggcccuuacuggaacugucaaaccacgaggucaugaaagccaucaacgacggcuuccggcuccccacgcccaugg

acugcccuucagccauuuaccagcucaugaugcagugcuggcagcaagagcgcucccgccggcccaaguuugccgacaucgu

uagcauccuggacaagcucauccgacgccccgacucccucaagacgcuggcugacuucgauccccgaguguccauccggcug

cccagcaccagcggcucggagggaguccccuuccguacgguguccgaguggcuggagagcaucaagaucgaacaguacacgg

aacacuucaugguggcuggcuacacggccaucgagaaggugguacagauguccaacgaagacaucaaaaggaucggagugcg

ucuuccuggccaccagaagcgcauugccuacagccugcugggacucaaggaccaggucaacacaguggggauuccuaucuga

guccauuggggcugucacacaauacuugaagagccacaguggucucccugccgaucuggugcuggcccacuggaacuuuau

uuauuucuguuuccucgucuaugccucccuaggacucugcaggggcuuuuugaaugacaccugccugagccugggaaacuu

ggauugcuggucagggcucucuuuccccugaaaaggacccagcuaagaacuuagcaguuugccauggccuucccagcauccc

cugaggcuaaaguuccaccaagagucgauaucgacgagggacauuuccaaacggaccuccccaucuucauuuggccuccuga

gaagccacucuggagcugaggcuaagcacuaagcccaggaccauaugacuagcacuguaccgcccgccccuaguuagagggu

agguuuuggacuuggcuggguuguggucacaagcaaucucccagugccuuuuacagaccccagucugcccucccgucgagg

gccagcuucuugcuuuccuagggcccucucaggaugcuuggcugugcugagguuuuuauuaaauauauauuuuauacuug

cggaaagaaugaguguguggcagggacuugccagggcuggagacagaggauccccugcaacaagacauucccgggcugggg

gcuggcggaccugcaggagacuuuccgccaccaccccgucuccagccccuuuggacaaaugucgcugucaguguuacagauu

ucuuuuauuggguuguuuuuuuguuguauuuuuuugaaccuuaacuuauuauuuuuuuuauauuuauuguuagaaaaug

acuuauuucugcucuggaauaaaguugcagaugguuca

168
X04663
Sequence below.

ccaaaaaccuuaauuuucuuucuuguucgguaccuacauuggaaccaccaaaaacaauuauuucaguaaaccguagccauga

gggaaaucgugcacauccaggccggacaguguggcaaccagaucggugcuaaguucugggaggucauaagcgaugaacaugg

caucgaccccaccgguaccuaccacggugacagcgaccugcagcuggaccgaaucucuguguacuauaaugaagccacaggu

ggcaaguaugucccucgagcuaucuugguggaucuagaaccugggacuauggacuccguucgcucagguccuuuuggccag

aucuucagaccagacaacuucguuuucggucagucuggggcaggcaacaacugggcuaaaggccacuacacagagggagcug

aguugguugacucugucuuggauguggugcggaaggaggcggagagcugugauugccugcaaggcuuucagcugacccac

ucacuggguggaggcacuggcucuggcaugggcacccugcucaucagcaagauccgggaagaauauccugaccguaucauga

auaccuucaguguggugcccucgcccaaagucucugauaccguggucgagcccuacaaugccacccugucuguccaucaguu

gguugagaacacggaugagaccuacugcaucgacaacgaggcccucuacgacaucugcuuccguacccucaagcucaccacgc

caaccuacggagaccugaaccaucucgucucggccaccaugagcggcgucaccaccugccuccguuucccgggccagcuuaau

gcugaccuucgaaagcuggcugucaacauggugccauucccacgucuccacuucuucaugccuggcuuugccccucucacca

gccguggaagccagcaguaccgggcccucacugugccugaacuuacccagcaggucuucgaugccaagaacaugauggccgc

cugcgacccgcgccacggccgguaccucacaguugccgccgucuuccguggacggauguccaugaaggagguggaugagcag

augcucaacgugcagaacaagaauagcagcuacuucguggaauggauccccaacaaugucaagacagcugucugugacaucc

caccgcguggccucaagauggcagucaccuucauuggaaacagcacagccauccaggagcuguucaagcgcaucucugagca

guuuacggcuauguuccgccggaaggcuuuccuccacugguacacgggugagggcauggacgagauggaguucaccgaggc

ugagagcaacaugaacgaccuggugucugaguaccagcaguaccaggaugccaccgcggaagaggaagaggauuucggagag

gaggcagaagaggaggccuaacggcagagagcccugcaucagcucaggcugcuuagaucccucagccuuucuccaacugccc

uuuguccuccaguuucuuucugcugccucugucuuguauuuguuuugcuucuguuuucucauuggggguaaauggugcc

uggcacauggcaggcacucaauaaauauuuguuugugg

169
X61232
Sequence below.

ggcagacaaaagaggccggcagugcagcucgcgggacgcauggccgggcgcggaggacgggugcugcuggcgcugugugcc

gcgcugguggccggcggguggcugcugacgcgugaagcccaggagcccggggcgccagcggcuggcaugaggcgccgccgg

cggcuccagcaagaggacggcaucuccuucgaguaccaccgcuauccagagcugcgcgaggcgcuggugucgguauggcugc

agugcaccgccaucagcagaaucuacacagugggcgccagcuucgagggccgggagcuccuggucaucgagcugucugacaa

ccccgggguccaugagccgggugaaccugaauuuaaauacaucgggaacaugcauggcaaugaggcgguuggacgggaauu

gcucauuuucuuggcccaguaccuguguaacgaguaccagaaaggcaaugagacaauugucaaccugauccacagcacccga

auucauaucaugcccuccuugaaccccgacggcuuugagaaagccgcauggcagcccgggcagcugaaggacugguuugugg

gccgcagcaacgcccagggaauagaucugaaccguaacuucccagaccuggacaggaucguauauguuaaugagaaagaagg

cggucccaacaaccaccugcugaagaaucugaagaaaauuguggaccaaaauucaaagcuugcccccgagaccaaggcuguca

uucacuggaucauggacauucccauuugugcuuucugccaaucugcacggaggagaccuuguggcuaauuacccauaugaug

agacacggagcgguacugcucacgaauacaguuccugcccugaugacgcaauuuuccaaagcuuggcucgcgcguacucuuc

uuucaacccagucaugucugaccccaaucgaccucccugcugcaagaaugacgaugacagcagcuuugaugauggaacgacc

aaugguggugcaugguacagcguccccgguggaaugcaagacuucaauuaccugagcagcagcaacugcuuugagaucacug

uggagcuuacgugugagaaguucccaccugaagagacucucaaaagcuacugggaagauaacaaaaacucccucaucaacuac

cuggagcagauacaccgagguguuaaaggguuuguccgugaccuucaggguaacccgaaugccaacgcaaccaucucugugg

augggauagaccaugaugucaccucggcuaaggauggggauuacuggcgauugcuugcuccuggaaacuauaaacuuacag

ccuccgauccuggcuaccuggcaaucacaaagaaaguggcaguuccuuuuagcccugcuguugggguggacuuugagcuug

agucuuucucugaaaggaaggaggaggagaaggaagaauugauggagugguggaaaaugaugucagaaacuuugaauuuuu

aagaaaggcuucuaacuaauugcuuucaucuaucuauagacuguaguaagaugcaauguggcucuuuucuuuuagguugug

ugcaguugauauuuaacauugauuuauuuuugaucauuaaguaauaguuacuaaucacguaaauacacccggacagaaaua

uaaugcuggacaucuucauucuacaucaacauucgcuuaaaucauucgaagccucuuuuaacguaaugggugacaaugucac

uugacagaugcaugagagucacgauauagcugacugugacccugcacugcaaucacauaguuccauauaaguuguccuuagu

cucuugugcugauucacuguauaagcaugauccugguaaugcacuuuggaugggaagaaaauguacgugcuuuucagaggg

gcucugaacagaaugaaaaccuaguucuugcguguacuuugaagaauggaauuguauuagucagcuguuaaugccacuuca

gaaguuugggguuuugucuugauuguagauugg

170
X14309
Sequence below.

gccacggacgccucucugaacggggauccaggcaggauuagagcugccucacugacuacaggccgugucgugucaccguuuc

ugcaggcaccaugagccaggacaccgaaguggacaugaaagauguggagcugaacgagcuagaaccggagaagcagcccaug

aaugcagcggacggggcggcggccggggagaagaacggucuggugaagaucaagguggcggaggacgagacggaggccggg

gucaaguucaccggcuuauccaaggaggagcuacugaagguagcgggcagcccuggcugggugcgcacccgcugggcgcug

cugcugcucuucuggcucgguuggcugggcaugcuggcgggcgccgugguuaucaucguucgggcgccgcgcugccguga

gcugccuguacagaggugguggcacaagggcgcccucuaccgcaucggcgaccuucaggccuuuguaggccgggaugcggg

aggcauagcuggucugaagagccaucuggaguacuugagcacccugaaggugaagggccugguguuaggcccaauucacaa

gaaccagaaggaugaaaucaaugaaaccgaccugaaacagauuaaucccacuuugggcucccaggaagauuuuaaagaccuuc

uacaaagugccaagaaaaagagcauucacaucauuuuggaccucacucccaacuaccagggccagaaugcgugguuccucccu

gcucaggcugacauuguagccaccaaaaugaaggaagcucugaguucuuggcugcaggacgguguggaugguuuccaauuc

cgggaugugggaaagcugaugaaugcacccuuguacuuggcugaguggcagaauaucaccaagaacuuaagugaggacagg

cuuuugauugcagggacugaguccucugaccugcagcaaauugucaacauacuugaauccaccagcgaccugcuguugacca

gcuccuaccugucaaauuccacuuucacuggggagcguacugaaucccuagucacuagguuuuugaaugccacuggcagcca

auggugcagcuggagugugucgcaagcaggacuccucgcagacuuuauaccggaccaucuucuccgacucuaccagcugcug

cucuucacucugccagggacuccuguuuuuagcuacggggaugagcuuggccuucagggugcccuuccuggacagccugcg

aaggccccacucaugccguggaaugaguccagcaucuuucacaucccaagaccuguaagccucaacaugacagugaagggcca

gaaugaagacccuggcucccuccuuacccaguuccggcggcugagugaccuucgggguaaggagcgcucucuguugcacgg

ugacuuccaugcacugucuuccucaccugaccucuucuccuacauacgacacugggaccagaaugagcguuaccugguggug

cucaacuuccgagauucgggccggucagccaggcuaggggccuccaaccucccugcuggcauaagccugccagccagcgcua

aacuuuugcuuaguaccgacagugcccggcaaagccgugaggaggacaccucccugaagcuggaaaaccugagccugaaucc

uuaugagggcuugcuguuacaguuccccuuuguggccugauccuuccuaugcagaaccuaccacccuccuuuguucucccc

aggccuuuuggauucuagucuuccucuccuuguuuuuaaacuuuugcagauuacauacgaauucuuauacuggguguuuu

ugucuucaaauaaaaacaucaccccugccucaug

171
U42386
Sequence below.

gncuuaagccncguuuauuuugaugnccuguuggcucagunaugnccaagaugccnauuguuuuugcccnaaauaaauuu

acugaacuugggcuaaaaccaaaccuuggcacacaggugugauacaacuuaacaggaaucaucgauucauccauaaauaauau

aaggaaaaacucaagugguagccugucuuaaggcuuuugauacuugcagauuggggaaaaacaaacaacaaacgucuugaag

cauauuaauggaauuaguuucuaauguggcaaacuguauuaaguuaaaaguucugauuugcucacucuauccuggauaggu

auuuagaaccugauaauagucuuuaaacaagccauuccagucaugaugaggugauguauggauacaugcauacauucaaagc

acuguucucaaaguuaaugcaaguaaauacagcaauuccucuuucaauguuuaggcagaucguuaacuaugagcuagccaaa

ugugggcauguuauuacagggaaaguuuaaaggucugauaacuugaaauagguuuaggagaauucaucuacuuagacuuuu

uaaaugccugccauaaaaaauugaaaugguagaauggcugaccacagcaaugaccagcccucaccuagggcucuggaugauu

uuuggucuaauaacgcaugcuaguguugauguuuuuuggucaagaugggaaugaacaggaagaauuaugcagcaggcuuua

uuuuaaaugccgauucacauuacucuguucaagcugcguugagauguuaaacuggcuuacuauagacuuuguaaaaaaaaa

aaaaaccaaacaaauggcuccagaagaguaacaaacugaaaucugagaucacacagguuggaaauauguacauaacugaacaa

ggugucaauucugcucuacagugcaguuuagucaguuuuaguugcauagguuuccauuguuuuuauagucuguuuaugcu

aaaucuggccaaagaugagcauuguccaccacuaaaaugccuaugccacugggaauucuggguuaauuuugugaccagaaug

cagugaucaaaauguucaaucuuuuuacaguggcauaggaagauggcaaaaauuuccuaaagugcaauagauuuucaagug

uauugugccuuguucuaaaacuuuuauuaaguaggugcacuugacaguauugaggucauuuguuauggugcuauuucaau

uagucuagguuuaggcccuuguacauuuggcccauaacuuuuuacaaaguacuucuuuuauugcacauucagagaauuuua

uauauaugucuugugugcguguccuuaaacuuccaaucuuauuuugucucuuggagauuguugaacgcagcuugucuagg

aaagggaugggacuagauucuaaaauuuauuugggaccaugggaaugauaguugggaagaaacuuugcacacgacagauuu

cuagauacuuuuugcugcuaguuuuauguaauauuuauugaacauuuugacaaauauuuauuuuuguaagccuaaaagug

auucuuugaaaguuuaaagaaacuugaccaaaagacaguacaaaaacacuggcacuugaauguugaaugucaccguaugcgu

gaaauuauauauuucgggguagugugagcuuuuaauguuaagucauaauaaacucuuaagucaaauuaagcagacccggca

uuggcguguagccauaacuuucugauguuaguaaaaacaaaauuggcgacuugaaacuaaaucaugccaagguuugauacac

uugucuugagauauuaacgaaacacuuccaaacacugauacaaaguguccagauucucagauguuuguugugugaguuuug

uuuaguuguauuuuuuuuucagugaaugucuggcacauugcaauccucaaacaugugguuaucuuuguuguauuggcaua

uucagugacuuguacauucagcaauagcauuugagcaaguuuuaucagcaagcaauauuuucaguuauguuuccaaauuaa

gaauggguuuaaacuugcugaauguaaagauugacccucaagucacuguagcuuuaguaguugcuuauuguauuaguuua

gaugcuagcacugcaugugcugugcauauucugguuuuauuaaaauaaaaaguugaacugcacagucuccuuuguuguugu

caauugugguuuacuuuuagaggugaaaauaaaguugugcucuugccucgugccaauauguacauaacugnacaagguguc

aauncugcucuacagngnaguuuagncaguuuuagungnauagguucccaunguuuuuaungncuguuuaugcuaaaucu

ggccaaagaugagcauugcccaccacuaaaaugccuaugccacugggaauccuggguuanuuuggngaccagaaugaaguga

ncaaaauguccanucuuuuuacaguggnauaggaagauggnaaaaauunccuaaagugnaauagauuuccaaguguuungu

gccugguncuaaaacuuuunuuaaguagggugcacunganaguauugaggncauugguuauggugcuauuuccanuuagu

cuagguuuaggcccu

172
U51126
Sequence below.

cucggucuccaagaugguggcuaacaaaacgugaggccuagagguugauccuaggucacuggaagcauguccuugaagagg

acuaugggcaucuggguucuuccucuucuacuuggccacgagguaaccggcuucuuguaccacgugugcucaccucuacaa

ucugugcggauucagacuccaagcaacuaggcuacccagugacaggcuaaaaacuacagcucuaacgucuuggaaggcgauu

ccauggaccaggauguggaaagcccaguggccauucaccagccaaaguugccuaagcaggccagggacgaccugccgagacac

aucagccgagacaggaccaaaaggaaaauccagagguacgugaggaaggaugggaagugcaacguucaccacggcaaugugc

gggagacguaccgauaccugacggacaucuucaccacccugguggaccugaaguggagauucaaccuguugaucuuugucau

ggucuacacagugacguggcuuuucuuugggaugaucugguggcugauugcguacauccggggagauauggaccacauaga

ggaccccucguggacuccuugugucaccaaccucaacggguuugucucugcuuuuuuauucuccauagagacagaaaccacc

aucgguuauggcuaccgggucaucacggacaagugcccugaggggauuauucuccucuuaauccaguccguguuggggucc

auugucaacgccuucaugguaggauguauguuugugaaaauaucccaacccaagaagagggcagagacccuggucuuuucca

cccacgcggugaucuccaugcgggaugggaaacugugcuugauguuccgggugggggacuugaggaauucucacauugugg

aggcauccaucagagccaaguugaucaaguccaaacagacuucagagggggaguuuauuccccucaaccagacugauaucaac

gugggguacuacacaggggacgaccggcucuuucuggugucaccauugauuauuagccaugaaauuaaccaacagagucccu

ucugggagaucuccaaagcgcagcugccuaaagaggaacuggagauuguggucauccuggagggaaugguggaagccacag

ggcaguucugaaaucgaaaucaagcagaggucuauaagaacacccuggagacccccaugcugcuggaucuuggguccaugaa

cugcuuuuauuugcugcaaucaaaaaugcuagucgcugaucugauaggagaggaaacgagacucagagccugaaggauaaca

cgcugagggcugauuucauacacucuucccggcuggaucaucccagcccccacagcguccaggcuuaguuucuuccuuugu

uuuaacaaucuauacuuccuccagccugggcgagcuaguauacccagaguuugguuuuguuucuuuucagagcuguaagcc

cagugcccagugaccucaucugggaggagaguuaagcaauaagaccugaaaugcuaaacucugggguagaaaaccucugcag

agacagcgucucugggaagucucuacagagacagaguagggaagucucacgaaggucagagucuuacuuccauaccuggaga

aauccgcccguccguucagugccgguuucaacuccucugccaaagacuucuuuccaagacacugguaucagcuaucccagca

guaacuuuggcaguauauaaaucaauggcacugccccauaaaaccccguugaguaaaaccuauggucuucaacagcugggga

gccuguagcccagcuccugugugaggcuaaggcuguggagaccaugccugcucaccuccucguugaaaagcaaaacacugua

agaaaccuaacaugacuuuuuccaacauuucucaggcuggggagaagacuugguccacaaagagcuugaggucuugaucug

gaucccuagcauccauggaagaaggugggcaugaucacccacacuccucaucccauagcucugaaugagguaggcagauucc

uggggcucaccagcucauccuaacagccaggucccaaugagggacugucuacaaaagaacaagagguggauccugagaagcg

acacccaagcuugaccucuagccccuguacacaccuguuaagcaccugggcaucgggacacacacucgcaauuugcaaacaag

gcaaauucucacacuucagaaggcacugagagaaucccauaagcucaaaaaguuaggagccaagauugaccauuaaugacuu

ggguugaaaagacuaaaccacuggauagaauguuucauuacuaaaacaccuuaccugaaaaguauuacugcucuucuuucug

caacuggaccaugcagagauccacaaagagaugcccagagauuauuagugauggucauaugauauacacaauguggacucua

agccaaggccccaucaacucagauccagaggcugacagugugcuuaucuuagagauaccacaguggcugccuaaucaccacg

uccuuaagucaggggaguuugauuauuuccuaugaacaccgaguggggacagcggauuaccaaugaagcaauccaaccugac

aauccuaaccacccagaagaggaucgcugggggaaagcaugaauuauuuacgugucaacaugugcacacuccggccacgcag

cucaacagccaggagugcuucuccacuuagcccugcccuggcauccauuuaugaucucgucuguuguguuaauuacccagcu

agcuuuuuucucaaaaauaauaucucccagccauagaccuacucaucuguguccucuuuaauuucaacccacaguuacauca

uucacuggcuugcucaguuucuucaacucugaaaugggaaugaugaugaugaugccucuuccccccaagccaccauccucccc

cgugaccuuccuagguacagacucaaaccagggaagauuauuuccuucucauaggccacagggugaaaugcaauaaagaaca

aagccuuguagggaggcagagggaaagaccaguccucacaagaggcuccauuguuuccagggacuuugaagcuuggacagaa

ugucagaugauccccuuugaaggugcuccaaagagucaaugugaaaaauauugacugaugugugcccguccacaagccaagg

ugccucugcccuggucaccuaccaugaauuauaaacugaugauauuugaaauaauaaggaacacuggagccggccagaaagg

auucugcagucccauaaauagcaacauucaucacuacaaugccugccaacgguggccgugaauguagauuacccccggcucu

ucugaggccacugaggacagggcaaacuaccucugagaauggaggcucacuguucugcaucccacuucuaaauguuccauga

auuuuuugagacaucucccauaucccuguuagaaagauucaaccuugugcuauuaaccaaaucauuuugaauuccauaaacc

ucuacucuaaaguauacacuuaauucuacaauacagacaacaaauaugacuuuuuccuaugaaagagugauaaagauacugu

aucagucugcuuugacucaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

173
AF093853
Sequence below.

uggaaugggugcuaggugaaggcuuuguugaaucaggaugcugagcugguguuuuuacagguccagauaugaugagcugg

aguuuugguaggcccagguaccuccuccaaaauugaccacauaauuggucacaaaucaggccuccacagauacaaaaauauu

gaaauuaucccaugcauccugucugaucaccacagacuaaggcugaucuucaauaacaacauaaaaauagaaagccagguuca

cugcugcggcugcgccuccuuguucucagcgucaccacugccgccaugcccggaggguugcuucucggggacgaagccccca

acuuugaggccaauaccaccaucggccgcauccgcuuccacgauuuccugggagauucauggggcauucucuuuucccaccc

acgggacuuuaccccagugugcaccacagaacuuggcagagcugcaaagcuggcgccagaguucgccaagaggaauguuaag

uugauugcucuuucaauagacaguguugaggaucaucuugccuggagcaaggacaucaaugcuuacaauggugaaacaccca

cggaaaaguugccauuucccaucauugaugauaagggcagggaccuugccauccuuuugggcauguuggauccagucgaga

aggacgauaacaacaugccugugacggcccgugugguguucauuuuuggcccugacaagaaacugaagcugucuauccucu

acccugccaccacgagcaggaacuuugaugagauucucagagugguugacucucuccagcugacaggcacaaagccgguugc

caccccaguugacuggaagaagggagagagcgugaugguaguccccacccucuccgaagaggaagccaaacaauguuucccu

aaaggagucuucaccaaagagcucccgucuggcaaaaaauaccuccguuauacaccccagccuuaagucuuugcggaaauug

gggcugcaucugcacguccagcacuggggccugaggacgucagccggcagccguggguccuugcagcagguccguagaaaga

ucguggcaugaucacagccgguccuguagaucgcucgcuauacuacugggucauuaaauggaaauggcaccaaaaccuucuc

gggauucuuuacucugugccuucgccagcauucugccccucugccugucacagugcccuacugacuggcucucuuugaaac

gaauuauguauugaagauuccuuaggucucugcagggucuuugaucagcaagcaagguagugucagugugggcucugugc

uagaaugaugaaacaccuuuuguagcuuuccgaacggaaucuucuguuacccauuuuggagagcacugacauggggagaag

cuuucaauucuguauuuuuaguaaauaaaguggggacagccgggagaauucuuacagggaaucuauuguaaguuucuaucg

aagugggcucagaaagccuuucgccucccaagagugcgcauguaccuccuagaguuuccacaucugcucucuggugauguc

ugccugugaacgcaccuuauaaaagacgggcggugacaguguuuuaccacucaguguccuaguaguggguggccauuucug

aauucugcuuuuugagguucaacaaauaaaauccugaucagaaaaaaaaaaaaauagaaagccaacauucauguggaaacuga

acaacacuacucaaugauuccuuggucagagaugaaauaaagaaagaaauuaaagacuuuuuagaguuuaaugaaaaugaag

ccacaacauacccaaacuuaugggacacaaugaaggcauuucuaagaggaaaacucauagcccugagugcauccaaaggaaaa

aaaaaaaaaccuagagagaguguacacuagcagccugacugcacacuuagaagcucugcaaaaaaaggaaucaaauucaccca

agaggaauagacagcaggaaauaaucaaacuuagggcugaaaucaaccaaauggaaacaaaaagaacuauucaaagagugggc

caaaccaggagcuaguucuuugagaaaaucaacaagauagauaaacccuuagccagacucacuagagggcacagggacagcau

ccuaauuaacaaaaucagaacugaaaagggagacauaacaacagauccugaagaaauccaaaacaccaccagauccucuacaaa

aggcuauacucaacaaaacuggaaaaccuggaugaaaggaaaagcuucuagacaga

174
Z19521
Sequence below.

augagcaccgcggaucugaugcgucgcugggucaucgcccugcuccuugcugcugccggaguugcaguagaagacucaggc

agcaggaacgaguuccaguguagagacggaaaaugcaucgcuagcaagugggugugcgauggcagccccgagugcccggaug

gcuccgaugaguccccaaagacaugcaugucugucaccugucaguccaaucaauucagcuguggaggccgugucagccgaug

cauuccugacuccuggagaugugauggacagguagacugugaaaaugacucagacgaacaaggcuguccccccaagacgugc

ucccaggaugacuuccgaugccaggauggcaagugcaucuccccgcaguuugugugugauggagaccgagauugccuagau

ggcucugaugaggcccacugcccagccaccacuuguggccccgcccacuuccgcugcaaaucauccauaugcauccccagucu

uugggccugcgacggggaugucgacuguguugacggcucccaugaguggccacagaacugccaggccgaagacacggccucc

aaaggcguuagcagccccugcuccucccuggaguuccacugugguagcagugaguguauccaucgcagcugggucugugac

ggcgaggcagacugcaaggacaagucagaugaggagcacugcgcgguggccaccugccgaccugaugaauuccagugugcag

auggcuccugcauucacgguagccgccagugugaccgugaacaugacugcaaggacaugagcgacgagcucggcugcgucaa

ugugacacagugugauggccccaacaaguucaagugucacaguggggagugcaucagcuuggacaaggugugcgacuccgc

ccgcgacugccaggacuggucggaugagcccaucaaggagugcaagaccaacgaguguuuggacaacaaugguggcuguucc

cacaucugcaaggaccucaagauuggcucugagugccugugucccagcggcuuccgguugguggaccuccacaggugugaa

gauauugacgagugucaggagccagacaccugcagccagcucugugugaaccuggaaggcagcuacaagugugagugccagg

ccggcuuccacauggacccacacaccagggucugcaaggcugugggcuccauaggcuaucugcucuucaccaaccgccacga

gguccggaagaugacccuggaccgcagcgaguacaccagucugcuccccaaccugaagaaugugguggcucucgacacggag

gugaccaacaauagaaucuacugguccgaccugucccaaaaaaagaucuacagcgcccugauggaccaggccccuaacuuguc

cuacgacaccaucaucagugaggaccugcaugccccugacgggcuggcgguagacuggauccaccgcaacaucuacuggaca

gauucagucccaggcagcguaucuguggcugacaccaagggcguaaagaggaggacacuguuccaagaggcaggguccagac

ccagagccaucguaguggacccugugcauggcuucauguacuggacagauuggggaacacccgccaagaucaagaaaggggg

uuugaaugguguggacauccacucacuggugaccgaaaacauccaguggccaaauggcaucacacuagaucuuuccaguggc

cgucucuauuggguugauuccaaacuccacucuaucuccagcaucgaugucaaugggggcaaucggaaaaccauuuuggag

gaugagaaccggcuggcccaccccuucuccuuggccaucuaugaggacaaaguguauuggacagaugucauaaacgaagcca

uuuucagugccaaucgacucacggguucagaugugaauuugguggcugaaaaccucuuguccccggaggacauuguccugu

uccacaaggucacacagccuagaggggugaacuggugugagacaacagcccuccuccccaauggugguugccaguaccugug

ccugcccgccccacagaucgguccccacucgcccaaauucaccugcgccugcccugauggcaugcugcuggccaaggacaugc

ggagcugccucacagaagucgacacuguacugaccacccaggggacauccgccguccggccuguggucaccgcaucagcuac

caggccaccgaagcacagugaggaucucucagcucccaguacuccuaggcagccuguggacaccccagggcucagcacagugg

cgucagugacagugucccaccaaguccagggugacauggcuggcagagggaaugaggagcagccacaugguaugagguuccu

guccaucuucuucccuauugcacugguugcccuccuuguccuuggggccguccugcuguggaggaacuggcggcugaagaa

caucacaaucaacagcauaaacuuugacaacccagucuaccagaagaccacagaggacgagcuccacauuugccgaagccagg

auggcuauaccuaccccucaagacagauggucagccuggaggacgauguggcaugagcagccgggagagccgucucuuuccg

ggauccauugccaagcuuaggcagaaaagacacucucuccagaccuccccauccagcacugguccugccaccucccugggucu

guguugcucaaagcaagauagagcaaagcugggcuggggggccaagcucagcuuccugucugccccagguucuguuuuaua

uauuuauugucugggacagaaaaggcuacuggcugugcuugaaauucga

175
U04354
Sequence below.

accggucaucgggcucuuccuugggcucagggcacggaucaaguccucggcucgcucggccagcaccgcggcaccauggcgc

aggagcugcagcaccccgaguucgcgcgcgcaggccagcaggcugggcugcagguguggagggucgagaagcuggaacugg

uaccggugccccagggugccuauggugacuuuuacgucggagagcccuaccuggugcugcacaccaccaaguccagcagggg

cuucuccuaccgccugcauuucuggcugggaaaggaguguucccaggaugagagcacagcggcugccaucuuuacggucca

gauggacgacuauuuggguggcaagccaguccagagcagagagcuucaaggcuaugagucgacugauuuugugggcuauuu

caaaggcggucugaaguacaaggcuggagguguggcuucuggacuaaaccauguccucaccaaugaucugacugcgaaaaga

cuucugcacgugaagggucggagaguggucagagccacugaaguuccccucagcugggagagcuucaacaagggcgacugcu

ucaucauugaccuuggcaccgaaauuuaccaguggugugguuccuccugcaacaaauaugagcgucugaaagcaagccaggu

ggccauuggcauccgggacaaugagaggaaaggaagaucucaacucauugugguggaagaaggaagugaaccaucagagcuc

augaagguuuuagggagaaagccugagcuuccagauggggacaaugaugacgaugucguagcagacauaaguaacaggaaga

uggcgaagcucuacaugguuucagaugcaaguggguccaugaaaguaacacugguggcugaagaaaacccguucuccaugg

gaauguugcuuucugaagaaugcuucauuuuggaccauggugcugcaaaacaaauuuuuguauggaaagguaaaaaugcua

acccacaggagaggaagacugccaugaagacagcugaggaguuuuuacagaaaaugaaguauucuacuaauacucaaauuca

gguucuuccggaaggcggugaaacaccaauuuucaaacaguucuuuaaggacuggaaggauaaagaccagagugauggcuu

ugggaagguguacaucacggagaaaguggcucagauaaagcagauuccguuugaugccucaaaacugcacaguucuccgcag

auggcagcccagcacaacaugguggacgauggcucuggcgggguggagaucuggcguguagagaacagugguagaguccag

auugacccaagcuccuauggcgaguucuauggcggugacugcuacauuauccucuacacuuaucccagaggacagaucaucu

acacauggcaaggagcaaaugcuaccagagaugaacugaccauguccgcguuucugacuguccaguuggaccggucccuugg

agggcaggcugugcagguccgugucucucaaggcaaagagccugcucaccugcugaguuuguucaaagacaaaccacucauu

auuuauaagaaugggacauccaagaaagaagggcaggcaccggcucccccuacacgccuuuuucaaguccggaggaaccugg

caucuaucaccagaauuguggagguugacguugaugcaaauucauuaaauucuaaugacacuuuuguccuaaaacugccacg

aaacaauggcuucaucuggauaggaaaaggugcuagccaggaggaggagaaaggagcagaguauguggcugauguccucaag

ugcaaagcuucaagaauucaagaaggcaaggaaccagaggaauucuggaacucucuuggagggaggggagacuaccagacuu

caccauugcuagaaacucgggcugaagaccauccaccucggcuuuaugguugcuccaacaaaacuggaagauucauuauuga

agaaguuccgggagaguucacccaggaugaccuggcagaagaugaugucaugcuacuugaugcgugggaacagaucuuuau

uuggauuggcaaagaugccaaugaaguugagaaaaaggaaucagugaagucugccaaaauguaccuggagacagacccuucu

ggaagagacaagaggacaccgauugucaucaucaagcaagggcacgagccccccacauucacaggcugguuucugggcuggg

acuccagcaggugguaaaaccagcaacuauccuggcugcauuggggcagcugccacuuuguuguuggggaauuguuuacuu

uuuguuauuggcuuuugaagauaaacuccugccaaauggauauauaucuauaucuauaucuauaucuauaucuauaucuau

aucuauaucuauaucuauaucuaucuauaucuaaucuauaucuaucuaucuaucuaucuaucuaucuaucuaucuaucuau

cuaucuauaugcuccucuuuuccuucucuuucaaagggaauugcuguauguuacuauacugaaauaaccuaaagcaaccauu

uguuuucgagcaauuuugcaaucuggggaccucugaggaaguaauuuugucauucagccacugcuagccaaacuugucuuu

ucccauagagaggaaggagagccacagugcuucuaagcauuuccccgucugcuacucuguuugcagugagcuuuacuuuau

guauggcuuuaacaaugccuugcuguuucccaucucaagucaaugccacuuggaugccauucacucccaaguguccuuacau

aggaugaacuucuuuagcuuuuuuagaaaacuaaaaucaugucuuuuaugauaaaacacauuuuauuucuauaaguuuaac

uuuauauauuugauagcacaugcucaauagcauaaagaauaugcauugaaugauguuuuucauaauuaaaauauauccuuu

ugg

176
M35244
Sequence below.

caggguugagagcaagaaggugcaggauguaggccagcagaauuaucagacccaguggcggcuucugccacuggaagaauuu

ccaacauaaaacagaugaucaguuugggacaaucgauucugcgaccagagguagugucaucugguuacuuuuaaaauucaga

uugucugguguuuuccaaucacucgcgacuguaauuugaaguuggauucugagauaauacaaucgcugucgcucuaguuua

uaaagcuguccaagaucugcccagucccagauguccuggguccucagggcggcuguggucugcgcccuucuccugcagcug

gaugccagaccauccuggacucggaucccuuuggguucacacucgcuuagguauuucuacaccgcugugucccggccuggc

cuuggggagcccugguucauaaucgucggcuauguggacgacaugcagguccugcgcuucagcagcaaggaggagacuccg

aggauggcacccuggcuggagcaggaggaagcagaugacugggaacagcagacucauauagucacaauucaaggacagcugu

cugaaaggaaucugaugacccugguucauuuuuacaacaagagcauggacgacucucacacacuacaguggcugcaggacug

cgauguggagccagaucggcaccugugucucugguacaaccagcucgccuaugauagcgaggaucuccccacccugagcgaa

aacccaaguuccuguacagugggaaacagcacuguaccucagaucucucagcaccuggagggccacugcucagaugugcugc

agaaauaccuggaaaaagggaaggagaggcugcugcguucagaccccccaaaggcacaugugacccgucaccccagaccugaa

ggugaugucacccugaggugcugggcccuggguuucuacccugcugacaucacccugaccuggcagaaggauggggaggag

cugacccaagauguggaguuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugugguggugccu

cuuggaaaggugcagaguuacacgugccauguggaccaugaggggcugccugagccccucacccugagaugggagccugcau

gguaccaaaagccuuggauuuggauuguugccacgguuuuuuccauuuugcucauuugucucuguguggcucgcagaccca

ugaagaagaaugcaggugggagaggaaggcgugacacccaagaagcaggcagagacaguccccaagacucuagcaagacugu

uguggaugaugaggagauggggguuugcuuuuggaagauuaaguccuguaaaacuugucuaggccacuccccaggaacuuc

aggaucaucugggagaugccccuuugaguggcugggcugugaggacagcaggccaguucuugccacccuggacagaaacaca

ucucaccuuucuggcucgaggaucugaacaccugucucuugccuacucggcuucuagucaggcauuuugucaccuugucaa

gggucccagggacacaaagcucccuccucucacccacagcacucuggguccuacccccaaugcuucagggacauuuaaucagg

ucaaauugggaucaauggcuuugaugcagaaaagaacuguggacuaauagagauaggguuuaauaaaaaaaauaucuuuuu

177
AW121930
uuuuuuuuuuuuuuuuucaacuuuaaagacuggauuugagguucagucugggucucuggg

ggggaccucugucaucacgccuauaaucaucccgagaguagucaucccuggagcuccacg

accgaucaucccgucugucauagcggucuucauagcgguccccaccuccucuguagucau

caucucuccgguacccacuuccaaaugcccuucugccacugccuauccuggagucauagc

cucggucauagucucugcugccucggucaucauagcgaucccggcccccauagcggucca

ugucucugcgugggccgucccgauauccgucccuauacccaucccgauaccggucugaau

cguaacgaucucgauacuugucuccaaagcuaucaucgccucuucuagguggguagucau

cacaacugucuguggugggacgggcccuccagucugugucuguuuug

178
AI852632
uuuuuuuuuuuuuuuuuggcccccaggcucugucucaaggaugggaauagaucaagccaa

acagugaaaaauaaggcaaaucguggcuucgggguuugagacuggcaccaauggcaaauc

agcagaggagaugcaaaugggguaacaaucacaguuagugggguaacaugagcaggcagg

aaacccuugagacaacacccaagguccacgucuucgcaugugcagggcacaacuccagca

gcaguuucugggcuuggaggcuuguuacucuuccuaccuuucccacccccuaaaagacac

caagauggagcccacgaagagauuacaucaagcucuucuggcuggg

179
U70475
Sequence below.

ucuaggacagccagggcuacacagagaaacccugucucaacuaaaacaaagcaaaccccccgaauauuguuuuuuauuugcg

gaugucuguuuauugagacgggguucauggcagacaugagugucucagugcauuugcuauccucucuucuaaaggggcgg

gggggggggugcgcuggagagguggcucagcaguuaagagcacugacuucucuuccagagguccugaguucaauucccagc

aaccacaugguggcuuauaaccaucuauagugagaucugaugccuucuucuugccuguaggcagaccacuguauacauaaua

aauaaaucuuaaaaggggggggaagguguggagcuaaaaguauggcaauaugcauaaguuuagcuauuucuguuguuuugc

agucaucagugagccaaacuaauucgaauggguagcuagaucuuguugcuuuuagcgaauauauauugagugaauggaauu

gacagucuucuguauucucauucaguuuguuuguguucuuccccaucagugauaacauguagugaacuaacccguguggac

caucuuaaccauggcuucuccuuccuuuucuguuuuaaacauaggacauggauuugauugacauccuuuggaggcaagaca

uagaucuuggaguaagucgagaaguguuugacuuuagucagcgacagaaggacuaugagcuggaaaaacagaaaaaacucga

aaaggaaagacaagagcaacuccagaaggaacaggagaaggccuuuuucgcucaguuucaacuggaugaagaaacaggagaa

uuccucccaauucagccggcccagcauauccagacagacaccaguggauccgccagcuacucccagguacacucgucguggug

ggagcuaaggaaaacucuagugagaaagcagacucucuggaguugaguucuuggucugccauuuacugugucuuuugugag

gaggagaaguucucaaacuucgcuucuugauaaucaggacacagaucacagggaggacuuugugaguucagaaacauccucu

guggugaugaaacagcggcagaaauacuguugggaguaaaagaaguaggcauugcucauugugguaggcagggcccugauu

guauggguaacugacuuaacuguguuaaguaugauucccauuuuauauucccaugucuaaacaacuaaagcauuugcccag

aacacucagaaagaaaugaagggagguuauugccuagcacagagcccugguucagucccccacgcuguucguuaaaggggag

ggacuaauaauuugaacacaaucugguuugaaucuaugcaaaucgauuucugaaaugagaccauagguuauuuuaugaaca

agucuuauugcucguugugacccugugcuuagaacauuucauaaaugaugcucucugugccuuuccccuuccuccagguug

cccacauucccaaacaagaugccuuguacuuugaagacuguaugcagcuuuuggcagagacauucccauuuguagaugacca

ugagguauaaaaauguuuguuuaacagcaaaacucccuuaucugauauuaguuccuuucaugugucuccaauuaagagaag

aaaagaaaauuuuagaaggaaaaaauugaucaaagaaauugucaaguaaacuguaugagagcuauauaaugcuuaaaaauaa

gaccuguaugggcuggugagauggcucaguugguaagaguacccgacugcucuuccgaagguccagaguucaaaucccagc

aaccacaagguggcucacaacauccauaacaagaucugacucccucuucuggagugucugaagacagcuacaguguacuuac

auauaauaaauaaauaaaucuuuaaaaaaaaaaaauaaggccuguaaacuacaaguccauuuuacuguauagcuggaaacagg

aaucagaauaauuuucccuggaaacuggauauagauauauaaaauauuuugacuaguaaagaacaacuauuaaucagcauuu

ggauuaaaaaaucuuaaucuguuguuugaagcauucugcuagauauuauggguacagauuaaguccuaaugaauguuuuua

uccauuuugaagucugccuuuaaauacauggagugaaauaaccuaggaguguauuaauauggagucacugggaggaggaaa

uguuucauuuuauaaaagcagccugagagcuguaggcccugcugcugucuguucuucaugccuuggcucucacucacauga

aucaaugucacgucaaucuuggcuuucuucacuugcauuucagucgcuugcccuggauauccccagccacgcugaaaguuca

gucuucacugccccucaucaggcccagucccucaauagcucucuggaggcagccaugacugauuuaagcagcauagagcagg

acauggagcaaguuuggcaggagcuauuuuccauucccgaauuacagguaagagagcucuaggagugugcuguuuucugcg

ggcccuuuuaaauuagucauccuaguuauuuauuauuuacaugcuaccuccucaaaggaagaaauugaugguguauuuaaa

uuacucaugagagcuucccagacucacuuaacacacauaguuuuuagguaaucagacugaauauuucuggauaaauucauuc

aaagacugaaagcuaauuuagaguucugacaaagauaaaauacuuaucuauugaaaaaugggaguugaaggaauuauugaaa

agaacaccuuggauuuggggguagggaauugaucuaaaaugcacuuagccucugcucauacaaugugaccuucuuuccuag

ugucuuaauaccgaaaacaagcagcuggcugauacuaccgcuguucccagcccagaagccacacugacagaaauggacagcaa

uuaccauuuuuacucaucgaucuccucgcuggaaaaagaagugggcaacugugguccacauuuccuucaugguuuugagga

uucuuucagcagcauccucuccacugaugaugccagccagcugaccuccuuagacucaaaucccaccuuaaacacagauuuu

ggcgaugaauuuuauucugcuuucauagcagagcccagugacgguggcagcaugccuuccuccgcugccaucagucaguca

cucucugaacuccuggacgggacuauugaaggcugugaccugucacuguguaaagcuuucaacccgaagcacgcugaaggca

caauggaauucaaugacucugacucuggcauuucacugaacacaagucccagccgagcguccccagagcacuccguggaguc

uuccauuuacggagacccaccgccuggguucagugacucggaaauggaggagcuagauagugccccuggaagugucaaacag

aacggcccuaaagcacagccagcacauucuccuggagacacaguacagccucugucaccagcucaagggcacagugcuccuau

gcgugaaucccaaugugaaaauacaacaaaaaaagaaguucccgugaguccuggucaucaaaagccccauucacaaaagaca

aacauucaagccgcuuagaggcucaucucacacgagaugagcuuagggcaaaagcucuccauauuccauucccugucgaaaa

aaucauuaaccucccuguugaugacuucaaugaaaugauguccaaggagcaauucaaugaagcucagcucgcauugauccga

gauauacgcaggagagguaagaauaaagucgccgcccagaacuguaggaaaaggaagcuggagaacauugucgagcuggagc

aagacuugggccacuuaaaagacgagagagaaaaacuacucagagaaaagggagaaaacgacagaaaccuccaucuacugaaa

aggcggcucagcaccuuguaucuugaagucuucagcauguuacgugaugaggauggaaagccuuacucucccagugaauac

ucucugcagcaaaccagagauggcaauguguuccuuguucccaaaagcaagaagccagauacaaagaaaaacuagguucggg

aggauggagccuuuucugagcuaguguuuguuuuguacugcuaaaacuuccuacugugaugugaaaugcagaaacacuuua

uaaguaacuaugcagaauuauagccaaagcuaguauagcaauaauaugaaacuuuacaaagcauuaaagucucaauguugaa

ucaguuucauuuuaacucucaaguuaauuucuuaggcaccauuugggagaguuucuguuuaaguguaaauacuacagaacu

uauuuauacuauucucacuuguuacagucauagacuuauaugacaucuggcuaaaagcaaacuauugaaaacuaaccagacc

acuauacuuuuuuauauacuguaugaacaggaaaugacauuuuuauauuaaauuguuuagcucauaaaaauuaaaaggagc

uagcacuaauaaaagaauaucaugacuuaaacuacuuuggacuuuuugaauuuauucacacuauuuuccauaggacaaucac

ucauuuaccacauuugguuauuuuacauuuucaaaauggguuugaaaauacagaggcauuuuauagccauguguggcaguc

caugauuuuuuauucccgacauucaggaggcagaagcaggcagaucccugggcuccaggacggccaaggcuacaugagagcc

ugucucaagaaagacaaacccuuucuauacuaaacguuagcuaggauugucaaggagaugguauauauccacaaugguaugc

cugcuguacaguacuguggcacagagaacaaaaccuguaaccuccuguguucuuagaaguggcauucuaagaagggcuagga

aga

180
U09659
ggccagcaggacucuccuugcagcagcggcccgaguucagaguccggagcugcgguggug

gcggcgaaggcgagagucauggcuggacaagcuuuuaggaaguuucuuccgcucuuugac

agaguauugguugaaaggagugccgccgaaacuguaaccaaagguggcauuaugcuucca

gaaaagucucaaggaaaaguguugcaagcaacggucguggcuguggggucaggagggaaa

ggaaagaguggagagauugaaccugucagugugaaaguuggagauaaaguucuucuccca

gaauauggaggcaccaaaguaguucuagaugacaaggauuauuucuuauuuagagauagu

gacauucuuggaaaguaugucgacugaaaucacuguugaaauggugucacgugaagcugc

cauuccacugaugucugaacuauuucaucauguaaauaauuu

181
AW124785
uuuuuuuuuuuuuuuuucaggucucauuuucguuuauuugaaauucggugcucguguaag

uuuuuucucuuccccucaaauuuuauuucaguaaaaggagacuugggcgagguggauacc

ccacagccggauucuucccccccugccccccaggguggcuaaugcuaucuggggaagucg

ucauagggaagagaacuaugggugggcuccugccugaggccuccaaucucagcccagugg

acauaucacaggcagcuuaaaaaaaaaacccuaaaaaaaacaccccaaaacacacauuua

aauagguauucaagacagcuuuaaaaaaugcacccacucacaccccccucccuuuucuuu

uuggaaaaaaaaauaggaaaaaaaaaaaaaccaaaccgaauucucgcuuggccucua

182
AF071315
Sequence below.

auuuggcuccgaggccaagaauucggauccaaggcgggcgcggggaaaauggcggcggcagcugcggcgggggcgaauggg

agcggaggcagcagcggcauggaaguggaugcagcaguccccagcgugauggccuccggagugacugggaguguuuccguc

gcucuucauccccuugucauccuuaacaucucagaccauuggauccgcaugcgcucccaggaggggcggccuaugcagguga

uuggggcucugaucgggaagcaggaggggcgaaauaucgaagugaugaacuccuuugagcugcugucccacaccguggaag

agaagauuaucauugacaaagaauauuauuacaccaaggaggagcaguuuaaacagguuuucaaggagcuggaguuucugg

guugguauaccacaggggggccaccugaccccucagacauccacguccauaagcaggugugugagauaauugagaguccgcu

cuuucugaaguugaacccuaugaccaagcacacagaucuuccugucagcguuuuugagucugucaucgauauaaucaaugga

gaggccacaaugcuguuugcugagcucacuuacacucuggccacugaggaagcugaacggaucgguguagaccacguggccc

ggaugacagcaacaggcaguggggagaacuccacuguggcugaacaccugauagcucagcauagugccaucaagaugcugca

cagccgugugaagcucauuuuagaauaugucaaggccucugaagcaggagagguucccuucaaccaugagauccugcgggag

gccuaugcccuaugucacugucucccaguucucagcacugacaaguucaagacagacuuuuaugaucaaugcaaugacgugg

ggcucauggccuaccucggcaccaucaccaaaacgugcaacacaaugaaccaguuugugaacaaguucaacguccucuacgac

cgacaaggcauuggccggcgaaugcggggacuguuuuucugaugaugguucuggaagggaugguguguggggcucagaca

gcuguuccauggaccugaguaccacauucccuuuagagaaacucauuaauaaaagagcagccccuaaaaaaaaaaaaaaaaa

aaaaaaaaaaaaaaaa

183
D49733
Sequence below.

aaaacccaauguuugguuuuaaagccaaaaauauaagggaagugcauagguuuggguuuuguuuuuuguuuuuucccgag

guccuugaucuuugcccccaaauuugagggcauaaaguaaucccucaguuaccuaaaaacacagccauuccuuugccauucc

acucuccuggauuggccgcuucugugcgcgggggagaggugacucacuauuacuacugaggaaaggggagccaguggugga

aguggggugagucacugaugggcagcagcuucagcccuccccccaacuuccuuggcucucuggggaugccugauccucuccc

ucacuuugcaccuacuuccccuggucccucaccacuacccuuugcccacccacucaaauucuuuggcucugcucuuuacucc

agaaggccaaaggcaagcuuagaguugaguaggcaggaaccaacauugugaagccccaggccagaaagggguguucugcaga

gugaggguuggcaugcuggcuccuccucaccauaccugcccccgccccuuuggguacaggauggcuccuuuaagagcagug

gauccacccccuguagaggagggccuauuagagccucugccuggcugucagugacucaguguucgcgggaacgcugccuca

gccucaacaccagccaacccagaucccgaggugcgccagcgcccagcccagaucuccacgccugccaggagcgagcuucgccg

gcucgcugucccccugagcagccucuguccuucuguccaagucccgcgcccuucucgggaccccugcccagcgggcagcacu

gucacccugccggccauggagaccccgucacagcggcgcgccacccgcaguggggcgcaggccagcucuaccccacugucgcc

cacucggaucacccggcugcaggagaaggaggaccugcaggagcucaaugaccgccuggccguguacaucgaucgcgugcgu

ucccuggagaccgagaacgcggggcugcgccuucgcaucacugagucugaagagguggucagccgagagguguccggcauca

aggcggccuacgaggccgagcugggggaugcccgcaagacccuugauucuguggccaaggagcgcgcccgccuccagcuaga

gcugagcaaagugcgugaggaguucaaggagcugaaggcucggugagugaggcccggccggccggcaccagggaggcagca

gucgccuguaacuggccaucuaguccccucccuccccggaacugccucccgcgggugacuggcagugccaannnnnnnnnn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn

nnnnnnnnnnnnnngcuaggccagauauagaaagcuuucuguauuuaauacacaguacaugcaucauucaugucuacauaa

uuaagauaaaggaagcugcauuguuaaugggaaaaaaaauagggucugggaauguagugugccuagcauuuacgaacuucg

ggguuuggguuugaucccagcaucucacaaaccacguguaaucccagcacuuggaagguagaggccggaggauccgaaguu

uaaggucauucuugacuacuuagcaaauucggggcacccuaggauaccugagacccugucaugaauaaaaauaaauaauaaa

uaaaccaauaugggucuagguugagcagcagcuugggcaggguagggccggaaguuagccagguagaggguugcaguccca

ggaggacccuggcugggagcagcaccucaguccccugcccaaccacagggggccaccgggucuuuccggaacuccugagggc

gcaaggccuugcucucucuggcccagccauggggaacgcggagggccggugaggcaggcggcaggcgggcgggcggggcgc

gggccgucauccccuccugcuccuuauuuuuagcccaguguagagucugggccgccugucccucccccaggacagggggag

gaaauunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnngaugccaacaauccuaauguaaugaugcccucuucugacagcugcggggac

cgcagagaggucccaucccagaugcacuccugaaaccugcuuuucuuuuucuagcaacaccaagaaggagggggacuuguug

gcugcgcaggcccggcucaaggaccucgaggcucuucucaacuccaaggaagcugcccugagcacugcucucagugagaagc

gcacauuggagggcgagcuccaugaccugcgggggcagguagccaagguaggccgcuguccugugaccccagugaccccacc

ugguccgacauaucauucggucccauuugccugcucaccuucacuucuccagucuagannnnnnnnnnnnnnnnnnnnnn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn

nnucuagauggggacagccaucaccucuccuuuggcauuuccugaacccccucccaccucuccaugaacuuggcuuucuccc

ucucagcuugaggcggcccugggagaggcuaagaagcagcuucaggaugagaugcugaggcgaguggaugcugagaacagg

cuacagacgcugaaggaggagcuugacuuccagaagaacauuuacagcgagguaagcgucccgcuguacaggucuuucuuac

uguggacagcugggaggggucaccuaauaaugccaggcuaagcgagggcugcccgugccuggccgguggaguuacgacuuc

uggucucagcuucuaaggaaccauugcgauguucuaaucuaagugucuccccuuaaccuuucaggaacugcgugagaccaag

cgccggcaugagacgcggcuuguggagaucgauaacgggaagcagcgagaguuugagagccggcuggcagaugcccugcag

gagcugcgggcucagcaugaggaccagguggaacaguauaagaaggagcuagaaaagacauacuccgccaaggugcuggccu

cauccuguccucucccuggugcugcccuggggacgggugggugguggcagggggccagggaugccuuccucaggcccccag

cuccagguuccugcucucauaacugugugcucccugcagcuggauaaugccaggcagucugcugagaggaacagcaaccucg

ugggggcugcccaugaggaacugcagcagucucgaauccgcauugacagccucucggcccagcucagccagcuccaaaagca

ggugacccucaguuuaccccucccaccuuggcucuggucuaagcagauacugcagaagcccacugagaagggggugggggag

ggacuccaggaccacaugcuaugguucugaaucugaugccugucuggcuuuccagggcucuccuuuagcuagcccugaucc

ucagagccucuauuuuacugugcaugaaggguuuuucauguuucuucugugccugccggagacugaaccagaggccucuug

cuugguagauaggugcuuucucacugaguuacaaacccagccgcauucccuacuuggagauagagcuucccuuggacugga

cauguagcucaguugguacagugcuugcuuauuauacacgauggccuggcuucuauccccaggaccnnnnnnnnnnnnnn

nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn

nnnnnnnnnnucuagagagagccuacagauccugagugucccucugccugccccugugccccucccucuucaucgacauca

gcccuugggagcucaucagacccuuugucuuccccgccccaguuggcagccaaggaggcaaagcugcgugaccuggaggacu

cgcuggcccgugagcgcgauaccagccggcgccugcuggcugagaaagagcgagagauggcggagaugcgggcgaggaugca

gcagcagcuggacgaguaccaggagcugcuggacaucaagcuggcccuggacauggagauccaugccuaucgaaagcugcug

gagggcgaggaggagaggugaacuaggaggggucuacagaacuugucaggggccucuggccgcaacuaccaugacuaacccc

gcaccgugucuccaccuuccccaggcugcgccugucccccagcccuaccucgcagcgcagccguggccgcgccuccucccacu

caucccagucucaggguggaggcagcgucaccaaaaagcgcaagcuggagucuuccgagagccggagcagcuucucgcagca

ugcucgcacuagcgggcguguggcgguagaggaagucgaugaagagggaaaguucgugcggcugcgcaacaaguccaacga

ggugggccugugaaccaggguggucuuuucaguggcugggaguucuugguucucguggagcaucugucucccuaucugag

aauuuggagugugugguaguccugucaucuuuaaauuguugggaagaugcaugauauagggaugggugacccuugagcca

auagucuagguuugaugccagagguagugguggaagccugucuuucuuuucuuuuucuuuuucuuuuucuuuuucuuuu

ucucuuucuucucucuuuuuuuuuuuuccgauggggucuugcccagguuggcuuugaucucccuaguuaagcuguucccc

ugccucagccuccauaguagcuggaacugcaggngcacacuggcgnccagccuaccuaagcuccugagugagauaauccaag

agucgguugaacucccuguccuccuuccuccuuccuccuuccuccacccuacuucaggaccaguccaugggcaacuggcaga

ucaggcgucagaauggugacgauccuuugaugaccuaucgcuucccaccgaaguucacccuaaaggcugggcagguggugac

ggugaguggaagggcacuugggacucuggcuggaguggagaaguuggccucaggacaggagcauuaaaaauaagcacaucu

cuuaaaccaucuuuucccagaucugggcuucaggagcuggggccacccauagccccccuacugacuugguguggaaggcgca

gaacaccuggggcugugggagcagccuucgcaccgcucucaucaacuccacuggagaagugaguauguugcagccgguagcu

ugcuggacaaggcucccccgggugaccauaaugggaacuagcuaccuccaacccaagggaaccugccuuggguuuaggaucg

cuuuccugagcccaagucccacccaguaagcaagccagaagucuccccaguagaauaauggguggaagucagccagugagug

uuaauagcagacuccagcuuacagagcaccgagcucucaguuguguccuuuuugcgcgugcgugcgcgcgugugcacaugu

gcauguguuuauccuuaguccccagcaucagagguuggacaagguuguauaaaggcccgggacaguucuaagugguuacua

uggguagacaggcugcacagcccucacccccugacucuugggccugggcuuauguccccacaggaaguggccaugcgcaagc

uggugcgcucacugaccaugguugaggacaaugaggaugacgacgaggauggagaagagcuccuccaucaccaccgugugag

uggcagccgccgcugaggcccagcccacaaggguagcccugccagccuagggcagcucucccaccuccaugccaaagucuuu

ucauuaaagaauguuuuggaaugccacuugcugcccuggccuuucuucucucuccucccucuaccuugaacagggaacccag

gugucugguaaggaagggaguggggacuugcugaugccauggauacuccacgguggcaguggacaggguucuggauuugu

guccugggaaggggcugggaggacagagguggccccagcccugccucucuuccucacucccauugcaugcacacuucucucc

ucucuccuuccacccuauugcaugcuucuccucagauuucccugcaacaauguucucuuuccuuccuguccccucacaaauu

aagucucuccaucuuugcucuuccucuugauugccccauaagugucuaagauucaggagagaguuaaagccacagcucuuu

auuucgaaggcuuccuggcuauuucccccaucaugcccuuccucccagccacaggucucccaaguccccaucacuugguugu

cuggguacagacagaggucaccuuccugcccaauggccaggaagcuccaagagcccacagccuaggugccgguccuaagaag

ucagucccaaacucgcugucccuccugagccuugucucccuucccaggguucccacugcagcggcucgggggaccccgcuga

guacaaccugcgcucacgcaccgugcugugcgggacgugugggcagccugcugacaaggcugccgguggagcgggagccca

ggugggcggauccaucuccucuggcucuucugccuccagugucacagucacucgaagcuuccgcaguguggggggcagugg

ggguggcagcuucggggacaaccuagucacccgcuccuaccuccugggcaacuccaguccccggagccaggugagucaucuc

ugcccuacagcaggacacugcucacugagcagcagggcagggcagcccaagggaguggggucccccuccuugcagucccucu

ugcauccugccccuccugucugaaccccagacucgaggucagggcaaggcccagagugugaggguuggggagacaaccccuu

uggggucagggagggagaggaagggccagccacugcugcucacaccucugccuucucuucucucuuagagcucccagaacug

cagcaucauguaaucugggaccugccaggcagggcugggggcagaggccaccugcuccccccucaccacaugccaccuccug

ucugcuccuuaggagagcaggccugaagccaaagaaaaauuuauccccugccuuugguuuuuuuuuuucuucuauuuuuuu

uucuuuuucuaagagaaguuauuuucuacagugguuuuauacugaaggaaaaacucaagcaaaaaaaaaaaucuuuaucuca

auccuaaguccuuccccuuucuuuccuuguaucugccuuaaaaccaaagggcuucucuaggagcccagggaaaggacugcuu

uuuauagagucuagauuuuuguccugcugccuuggcuuuacccucaucccaggacccugugacaauggugccugagaggca

ggcauggaguucucuucaccagccuccuccaacagcuggcccacugccacgccagcugcagagaaauggggcgcagagagga

ugacugagaaggucaagccccuccccggcacuacacgaggccgaggcuccucugccugccuuaccuucuuccugcccuuccc

uagccuggggcgaguggauucccagaggcaaaucugccgugcuugcuuuuucuauauuuuauuuagacaagagaugggaau

gacggggaaggagaagggaagaucaguuugagccuaccuuuucccagcuucugagccuggugggcucugucucaaugaugg

agggcaaugucaagugggauacagggaagagugggggacgaaggcucccagagauggggagaaccugcuggggcuggugag

aagucuagaggugcggcgauugguggcuacagcaaacacuaaggaacccuucaccccauuucccaucugcaccucugcucuc

cccuccaaaucaauacacuaguuguuuccaucccagaugcuguggugucucuuuguugggugugauguguguuuucaggg

gcagacacaugcacacagaggugccacacauucacuauauauucacuacccagcuauaaagguguguaugagggagacuucu

agaaaggucagcauauguggggugagcgagggguguccuuccuaucccucauccauccagcaccuuuuaaaaggggccagca

auccacaugugcaucagacacaggagcacagagagacggaggguagaguagggcagaguagcagagcuuccuugcugcccug

uagucgcaggcucuugaucgugugaucgcu

184
X80899
Sequence below.

gcggugcgaagcgggccuccgccaacauguacuacaaguuuagcaguuucacgcagaaguuggcuggagcuugggcuucgg

aagccuacaccccgcagggguuaaagccaguuuccacagaagcaccaccuaucauauuugccacaccaaccaaacugaccucc

agugugacagcauaugauuauucugggaagaacaaaguuccagagcugcagaaguuuuuccagaaggcugaugguuuccac

cugaaacgaggccuuccagaccaaaugcuuuaccggaccaccauggcucugacacugggagggaccaucuacugccugaucg

cccucuacauggccucgcagcccagaaacaaaugagcuugccuguggaggacugguucacuuuguggcacaaacccuuugaa

uccucacguuucauguuuuccacuuggauagucuacuuaacauuuugcaaacaaaggaaaagauaagaauacauuguuuug

auuuguuuauggugugcagauggccugucagaugucagagcugguuugacaguuaaaacuauuguuuaaggaaaugucac

ugagccaucacugagcugugcuucugcuccugauuucccuggaguucugcaggaaaguugcucuccagcucauucguggcc

agccgugcucagggccucgggacucaggcggugucugagcgggaagcgaacgcggaagccuuuuggaguguaggugugauu

gaggaaggaaaacaaaagccagcggacagguggugaagugagggcugaguuagccacccuagggauucguccgccuugcaga

aaacauugagaggaaugauagcaaccugccucuauuugugggcaguugguuucaaaggguugugugucucgcccagaaccu

agggaaauggguguuuguuccaucgugggaggagcaccugucagugcugcacauuagacagcugugucaggacuucuccuu

uaauaaugcuguggcuuuacguuaugauugaccggacugcggaauaaacacuggaaucaaaaaaaaaaaaaaaaaaaa

185
D83203
Sequence below.

cugagacagaacgaaacguccgcagauaacuacccguucuggcucuuguuaguucuauguguauggauaaugucuugggag

guuuugaaaugccacaagccuugcuggcccagggugcagcugccucugccguucagaccucagauuauaaggacagaacaca

gcacggaaguggggggaucagaaccaugggagauccaggacgaaggguccugugcgcaggugcggcaccgaauccuauauu

ugacauugaagcugucgucagcccaacuaguguguuauuaacauggaagcacaaugacucaggcgcuucagaauguagaaua

gagaauaagauggagagcaaucugacguuuccuguuaaaaaccagacaucauguaacauuacaggcuuaagcccagguacuu

cguauacauucuccaucaucucuguaacaaccaaugagaccuugaacaaaacuaucacaacagagcccuggccagugucugau

cuccaugucaccucugugggugugacacaggcucgucucaccuggagcaaugcaaauggcacugccuccuaccggaugcuga

uugaagaguugaccacacauuccucagucaauauuucaggucugaagccggggaccaauaauacguucgcuuucccagaauc

aaaugagacacaggcugacuuugcaguugcagaggaggucccggaugccaaugguaccaagagaaucccagugaccaaccua

ucccaaccacacaagaauucucuugccucuguggacccacccucuggccaggaucccucccucacagagaucuugcuuacuga

ccuaaagccugauacucaguacaaugccaccaucuauucucaagcagcaaauggcacugaaggacagcccaggaacaaagugu

uuaaaacaaauuccacccagguuucugacguccgagcuaugaacaucagugccucaagcaugacccugaccuggaaaagcaau

uacgaugggucccguacuucaauugucuacaaaauacacguggcugggggggaccacuccgucaaccaaacugucaauaaga

cugaggccaucauccucggacucagcuccagcaccuuguacaacaucacaguucauccuuuccugggucagacggagggcac

accaggcuuccuccaaguguacacuucccccgaucaggucucugacuuccgagugacaaaugucagcacaagggcaauuggu

uuggcuuggaggagcaaugacuccaaguccuucgagauuuucaucaagcaggacggaggugagaagcaucgaaaugcuucg

acgggaaaccagagcuauaugguugaagauuuaaagccuggaaccaguuaccauuuugagauaauuccacgaggaccagacg

ggacagaagggcuguccaguacagugaaugggagcacugaccccagugccgugacugacauccggguggucaacauuagcac

cacugaaaugcaguuggaguggcagaauacggacgaugccucuggauacacuuaccauuuaguucuagagucuaaaaguggc

uccaucaucaggaccaacaguucucagaaguggaucacaguagggagccucaccccaggcaccuuauacaaugucacaaucuu

uccagaaguggaccagauccagggaaucuccaacuccauuacccaguacacacggcccagcagugugucccacauugaaguaa

acaccaccaccaccacggcagccauccgauggaagaacgaggacacagccucugcuuccuaugccuacuccguccuuaucuug

aagacuggagauggcagcaauguaaccagcaacuucacaaaagacccuucuauucuaaucccugaguuaaucccuggcgucu

cuuacacagugaagauccuuacacaaguuggggaugguacaacaucacugguaccugguuggaagcuguucuguacggaacc

ugaaucagugaccuccuuccacugugaaguggucccuaaggagccagcauugguucucaagugggccugccccuuuggcau

guacacaggcuucgagcugggggucaggagugauuccugggacaauaugacacgccuagagaacugcacaucggaugaugac

acagagugcaggacggaagucgccuauuugaauuuuucuaccucguacaacaucagcaucgccaccuugucaugugggaaga

uggcgcuucccgcccagaacaucugcaccacuggcaucacagacccaccuacuccggauggauccccuaauauuacaucgguc

agucacaauucaguaaagguuaaguucagcggguuugaagccagccacggaccuaucaaagccuaugcugucauccucacca

ccggggaagcugcccaaccuucugcagauguuuugaaguacacguaugaggauuucaaaaggggagccucggauacuuaug

ucacauaccucauaagaauagaagagaagggacagucucagggcuugucugaagucuugaacuaugaaauugauguggggaa

ccaauccacuacccucggcuacuacaacgggaggcuggagccucugggcuccuaccgggauuguguugcuggcuuuaccaau

auuaccuacaaccuucagaaugacggccucaucaauggggaugagagcuaugugucuuucaguccauauucagaggccgug

uucuugccccaggauccaggugucaucugcggagcaguguuuggauguaucuuuggugcccuggccaucacagcuguggga

ggcuucaucuucuggagaaagaaaaggacagaugccaagaauaaugaaguguccuuuucucaaauuaaaccuaaaaaaucca

aguuaauccgaguggagaauuuugaggccuacuuuaagaaacagcaagcugacucuaacuguggguuugcagaggaauaug

aggaccugaagcugauugggauaaguuuaccuaaauacacagcugagauagccgagaacagagggaagaaccgcuacaacaa

uguucugcccuaugauauuucucgagucaaacuuucaguccagacccauucgacagaugacuacaucaaugccaacuauaug

ccuggcuaccauuccaagaaagauuucauugccacacaaggaccuuuacccaacacuuugaaagauuucuggcguaugguuu

gggagaaaaacguauaugccauuguuauguugaccaaaugcguggagcagggaaggaccaaaugugaggaguacuggccuu

ccaagcaggcucaggacuacggggacauaacuguggcgaugacaucagaagucguucuuccagaauggaccaucagagauuu

uguggugaaaaauaugcagaauagcgagagccauccucugcggcaguuccauuucaccuccuggccugaccacgguguuccu

gacaccacugaccugcucaucaacuuucgguaccugguccgggauuacaugaagcagauaccccccgagucaccaauucugg

ugcauugcagugcugggguuggaaggacgggcacuuucaucgccaucgaucgccugaucuaucagauagagaaugagaaca

ccguggacguguaugggauugucuaugaccuucggaugcacaggccucugauggugcagacagaggaccaguauguuuucc

ucaaucaguguguuuuggauauuaucagagcccagaaagacucaaaaguugaucucaucuaucagaacacaacggcaaugac

aaucuaugaaaaccucgagccaaguuccuugaaugugacuauguugcuucauccacagcugaacgauuuuggauguugggu

ucuagguccuggcuguugcuggucugcuaggauccagggccuuguugacaucugggaagauguaaauugucccgcugaagg

ccgcaguuuuagauguggccacuagauggagccagagcacugguaugaaggagcaccagggccguguaaggcaaaagaggac

ccagaaaaagaaacuuaacuuguucacuccugagaaaccugcaagucaacaagccaaggaagugccuuugcaugcauuuggu

agccuuuccaaucccgcuuauuacauaauauguucauguucauggcaaaaaaaaaaaaaauaaaauaaaauaaauaaaaaagg

aaaacaaaauaaaaaaaaucuuagaacauu

186
Z20410
gcccccucaagggcauccugggcuacacugagcaccagguggucuccucugacuucaaca

gcgacacccacuccuccaccugacgcuggggcuggcauugcccucaacgaccacuuuguc

aagcucauuuccugguaugacaacgaauuugcuacagcaacaggguguggaccucaugg

cccacauggccuccaagguaagccccuggaccaccagccccagcaaggcacaagaggaagg

agagacccu

187
AI839906
uuuuuuuuuuuuuuuuucauauuaaacuuguaguuuuauucagguuugauuuuuaaca

aaugugucagggagagagcccacaggaaaggguaaagcccgugggggcaaggccuuccca

gaugccugaggagggaucguguccccucccccccuccucuucucaccaccccuacagggg

uuugggaagagacacaggcagggaaggggcugguccccagucuguacaguggugcuugg

gggugaaggacuauggagaacaggggaccagaucggggaugaguaggauaaagggcaca

agaccauuuaccagaauccagcuuucugauuccaaauugaauuaaaaagaaaaaaaggag

aggggaaccuaaaccacaagcaguacccaacucccuuucccccaucagggcugc

188
AI843448
uuuuuuuuuuuuuuuuuagggaagaggcugaugccagauaaguuuuuauuauauuaaa

aaaaaaaaaaaaaccagugcaacuggaaaucagggugagucgcuggaggugagugagagu

cggaaggcccuccacaccucagugguggcaggaucuggacccguagccuaagccuggucu

gauccagccgagaugcuggaaagcagagcacacgguggugcccaucagggcaaagagggc

aagagagcccacggcuccuccauaccgcuugcuagggucuccuguguaguagccauaugc

guaaaggacucgcccaauaauccaggccaggcccaggccagaagcuaugcgcggguggua

aacaccucccaccguuaggaaaaa

189
AW125336
cggccgcgugaguuuugacugagcuucugcangaaguucanaugcaacuccauacauca

guucauuuucuagcauuaccacuggguuauuaucacgaauggccgauuuaauaaguccu

uuugcauccucggaauuccaggggcugaccacuuuuaaaccugggcagugcccauacca

ugcagcaaagcauugcgagugcugagcagcuacaccugcugaggcgccauugggcccccu

gaauacuaugggcaca

190
AW123802
uuuuuuuuuuuuuuuuugaagggccauuggaguuuauuuacagacaaccuuaggugag

gccuuuuccucuaggaucuacaugcuuuugaaguuacuugguuucaggcuucuugucu

ccagcuucgagcuugagacucucaggaggcuggcgauaggcagggaaagccucccaggg

gcuguucaggucaaacuugcggaauucuugugccagcuccacugguucagccacuaccc

gcuuuaccucaucgucguaacgaagcucaacauagccagugaggggaaagucuuuccgga

aaggaugucccucgaagccauaaucugucaggauccuucuuaaaucagggugguuaaaa

aaaaaaaaaaaaaaaaaa

191
AI835771
uuuuuuuuuuuuuuuuuggggggcagcgaacuuuauugaugguauucaaaaaaauagg

gagggcucccuaggcccccccuguuauuaugggggucugggauggaaauuuugagggaa

augcucaauuuugggggcccauuugggaaaaggccccccuugcccaauguccuugcugg

ggugggugguccaagguuucuuacuccuuggaggccauuuuggccaagagguccaccac

ccuguugcuguagccguauucauugucaaaccaagaaaugagcuugacaaauuugucau

ugaaaaaaaugccaaccccggaaucaaagg

192
X53584
Sequence below.

gcuccucaucucacucgggccuaugccaaagauguaaaauuuggugcggaugcucgagccuuaaugcuucaagguguagac

cuuuuagccgaugcuguagcuguuacaauggggccaaagggaagaacagugauuauugaacagaguuggggaagucccaaa

guaacaaaagauggggucacuguugcaaagucaauugauuuaaaggauaaauacaaaaauaucggagcuaagcuuguucagg

auguugccaauaacacaaaugaagaggcuggggauggcaccaccacugccacuguucuggcacggucuauugccaaggaggg

cuuugagaagaucagcaaaggggcuaauccaguggaaauccggagaggugugauguuggcuguggaugcuguaauugcuga

acuuaagaaacagucuaaaccugugacaaccccugaagaaauugcucagguugcuacaauuucugcaaacggagacaaagaca

uugggaacaucauuucugaugcaaugaagaagguuggaagaaagggugucaucacagugaaggauggaaaaacccugaauga

ugagcuagaaauuauugaaggcaugaaguuugauagaggauauauuuccccauauuuuauuaacacaucaaaaggucaaaaa

ugugaauuccaagaugccuauguuuuguugagugaaaagaaauuuuccaguguucaguccauugucccugcucuugaaauu

gcuaaugcucaucggaagccauuggucauaaucgccgaagauguugacggagaagcucuaagcacgcugguuuugaacaggc

uaaaaguuggucuucagguuguagcagucaaagcuccaggguuuggggacaacaggaagaaccagcuuaaagauauggcua

ucgcuacugguggugcgguguuuggagaagaggguuugaaucuaaaucuugaagauguucaagcucaugauuuagggaaa

guuggagaggucaucgucaccaaagaugaugccaugcuuuugaaaggaaaaggugacaaagcucacauugaaaaacguauuc

aagaaaucacugagcagcuagacaucacaacuagugaauaugaaaaagaaaagcugaacgagcgacuugcuaaacuuucagau

ggaguagcuguguugaagguuggaggaacaagugauguugaagugaaugagaagaaagacagaguuacugaugcucucaau

gcuacaagagcagcuguugaagaaggcauuguucuaggagggggcugcgcucugcuucggugcaucccagccuuggauuca

uuaaagccugcuaaugaagaccagaaaauagguauagaaauuauuaaaagagcacuuaaaauuccugcaaugacgauugcua

agaaugcagguguugaaggaucuuugauaguugagaaaauucugcagaguuccucagaaguugguuaugacgccaugcuug

gagauuuugugaacaugguggaaaaagggaucauugauccaacaaagguugugagaacugccuuacuggaugcugcugggg

uggccuccuugcuaacuacagccgaagcuguagugacagaaauuccuaaagaagagaaggacccuggaaugggugcaauggg

uggcaugggaggggguaugggaggcggcauguucuaacuccuagaguagugcuuugcccuuaucaaugaacugugacagga

agcucaaggcagguuccucaccaauaacuucagagaagucaccuggagaaaaugacugaagagaaggcuggcugaccacugu

aaucaucaguuacugguuuccuuugacgauauauaaugguuuacugcugucauuguccaugccuacagauaauuuauuuug

uauuuuugaauaaagaacauuuguacauuccugaugcugguugcaagagccauauaccaguguccugcuuucaacuuaaau

cacugaggcaucucuacucuucugugagucaucaggacuguagcgcugugucaacaaaacauagagaguucagaagacagcc

uuucuguggaagggugggaaugauuguguacaaaguagagaaguauccaauuaugugacaaccuuuguguaa

193
M32599

acagccgcaucuucuugugcagugccagccucgucccguagacaaaauggugaaggucggugugaacggauuuggccguau

ugggcgccuggucaccagggcugccauuugcaguggcaaaguggagauuguugccaucaacgaccccuucauugaccucaac

uacauggucuacauguuccaguaugacuccacucacggcaaauucaacggcacagucaaggccgagaaugggaagcuuguca

ucaacgggaagcccaucaccaucuuccaggagcgagaccccacuaacaucaaauggggugaggccggugcugaguaugucgu

ggagucuacuggugucuucaccaccauggagaaggccggggcccacuugaaggguggagccaaacgggucaucaucuccgcc

ccuucugccgaugcccccauguuugugaugggugugaaccacgagaaauaugacaacucacucaagauugucagcaaugcau

ccugcaccaccaacugcuuagccccccuggccaaggucauccaugacaacuuuggcauuguggaagggcucaugaccacagu

ccaugccaucacugccacccagaagacuguggauggccccucuggaaagcuguggcgugauggccguggggcugcccagaac

aucaucccugcauccacuggugcugccaaggcugugggcaaggucaucccagagcugaacgggaagcucacuggcauggccu

uccguguuccuacccccaauguguccgucguggaucugacgugccgccuggagaaaccugccaaguaugaugacaucaagaa

gguggugaagcaggcaucugagggcccacugaagggcaucuugggcuacacugaggaccagguugucuccugcgacuucaa

cagcaacucccacucuuccaccuucgaugccggggcuggcauugcucucaaugacaacuuugucaagcucauuuccugguau

gacaaugaauacggcuacagcaacagggugguggacccucauggccuacauggccuccaaggaguaagaaacccuggaccaccc

accccagcaaggacacugagcaagagaggcccuaucccaacucggcccccaacacugagcaucucccucacaauuuccauccca

gacccccauaauaacaggaggggccuagggagcccucccuacucucuugaauaccaucaauaaaguucgcuugcacccac

194
AF035644
agaagcuuccuaaggaacaagcaaguugaauagagaaaauagugaucaauaauaggcauu

uuaguggucuuuuuaauguuuucugcugcggaacauuucaagauuuauugauuuccucc

uccccccauuuuuuucccaccacacucacacacgcacgcucacacuuuuuauuugccauaa

ugaaccguccagccccuguggagaucucuuaugagaacaugcguuuucugauaacucaca

accccaccaaugcgacucucaacaaguucacagaggaacuuaagaaguacggagugacaa

cuuugguucgaguuugugaugcuacauaugauaaagcuccaguugaaaaagaaggaaucc

acguucuagauuggccguuugaugauggagcuccacccccuaaucagauaguagaugauu

ggcuaaaccuguuaaaaaccaaauuucgugaagagccaggcuguuguguugcagugcauu

guguugcaggauugggaagggcuccugugcuaguugcgcuugcauugauugaaugcggaa

ugaaguaugaagaugcuguucaauuuauaagacaaaaaagaagaggagcauucaauucca

aacagcugcuuuacuuggagaaguaccgaccuaagaugcgguuacgcuucagagauacca

augggcacugcuguguucaguagaaguagaagcaggcuggcuggaucguggcauuagagg

gaa

195
Y00629
Sequence below.

auucagguuccucacagacccagggggugaggauguugcuuuuugcccacuugcuucagcugcuggucagcgccacagucc

cgacccagaguaguaagugaggggaggggugaggggagggguugggagcgaaaaagacucugugaggaaaagcgggagggu

ggugguggcggaggugcagcaccccaaguuccgccgcccuguccuagucccucccccgccuuuaccugggaccuugagccug

ggggaggucggggucucaccgcgcgccgcccccaggcccacacucgcugcgguauuucaccaccgccgugucccggcccggc

cucggggagccccgguucaucauugucggcuacguggacgacacgcaguucgugcgcuucgacagcgacgcggaaaauccga

ggauggagccucgggcgcgguggauugagcaggaggggccggaguauugggagcgggagacuuggaaagccagggacaugg

ggaggaacuucagaguaaaccugaggacccugcucggcuacuacaaucagaguaacgacggugagugcggcugggaucacag

cuaugaucacuccauguccccugagacgggccugggucaucuugacccgcugagacaaaguuucauccaaacgccuacccag

aaccucagacaaaaaagcccccgcagaguucugcuuagguuugggguuguacuuuuguuucucuuuuguuuugagauaucu

acuaacauugggcaaaguggccacagguggcgcucaucagcguaucccuuccagaaucucacacgcugcaguggauguacgg

cugcgacguggggcccgaugggcgccugcuccgcggguauugucaggaggccuacgauggccaggauuacaucucccugaa

cgaggaccugcguuccuggaccgcgaaugacauagccucacagaucucuaagcacaagucagaggcagucgaugaggcccac

caacagagggcauaccugcaagguccuugcguggaguggcuccauagauaccuacggcugggaaaugagacacugcagcgcu

caggugcccuggagagcucuccucacuuuuccucugcgguuugggggaaauccuugagguauaaccucaggggcagaacgc

uguucagcgggcacagcgcggaggaggagggagagggacucccaaaacugcuuuuccccuguagggauucuaauccuuaaca

aaagcagaucaggcucgacaauggcccuggacccauggggggagggggcucuuucucaggccucccuccuugcccuacucag

ugucucuauagucagacuccagcuuuucucaaucucuuggcccucauccagcucaggaccagaagcccuucccaugagucug

cagagaccuggagccuccuguccauguuguccugcucacauccuaaggcaucccuaagagcagauccucccaggugcaggug

cucuagcuggugucuagaugauggacaccauaaucccaccgcaguccuccuguccaccccaggacggucacaugaacacugc

ugaguccccagaagaaagcaagaugccucauccuuucaacucucucccucagacccuccaaaggcacaugugacccaucaccc

uagaucugaagaugaagucacccugaggugcugggcccugggcuucuacccugcugacaucacccugaccuggcaguugaau

ggggaggagcugacccaggacauggagcuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcuguc

guggugccucuugggaaggagcaguauuacacaugccauguguaccaugaggggcugccugagccccucacccugagaugg

gguaaggagggugugggugcugaacuggggucagggaaagcuggagccuucugcagacccugaguuggucauggcucagag

cugggaucauaacccucaccuucauuuccuguaccuguccuucccagagccuccuccauccacugucuccaacaugguaauc

auagcuguucugguuguccuuggagcugugaucauccuuggagcugugguggcuuuugugaugaagaggaggagacacau

agguaggaaagggcagggucugaguuuucucucagccuccuuuugcagugugcucugcuccuuaaugggaaacauagccac

acccacauugcugcagucuccaacugggucagcugucaguuccgggaacucccuagggcugguguuucucuggucucucau

ggcuuuucuucucacagguguaaaaggaugcuaugcucauguucuagguaagugcgagagaggggcaggggacacccuugu

cccugaggcucucaggauggagcugggauuuguuccagcccauaaucuccucuugccacauccucucugucuccucugugu

gccuuguuaucucuucuacugcaggcagcaagagcuuccagaccucugacuggccucagaaggcaugaaaaucccugggggg

gcuggugagauggcucaguggguaagagcacugacugcucuucugaagguccagaguucaaaucccagcaaccacauggug

gcucacaaccauccguaacgagaucugacucccucuucuggagugucugaagacagcuacaauguacuuacauauaauaaa

196
AW125380
uuuuuuuuuuuguucccuugaaagccagauguuccaaaaaguagccugcuccauuguucu

ucucagucucauagcgacugccagcgucaauccacacucccaccgugcagguagcaugcg

aggacugcuccgaggccacacgcagcccguuguccaagaugcugaccugggucuccggca

cgcucuggagggccugggcgaagguugcgguaccccgcaaggcagguaaccucagcaggg

ccggcgagcggcgggugcgccucgugccg

197
U68564
Sequence below.

ggugcuuaauguuuugaccuguagagguccucacuuuucgucauggcgcugaagguggcgauagcugcuggcggugcugc

aaaggcaaugcucaagccaacucuccucugccguccuugggagguucuggcugcccauguggccccccgaaggagcauuucc

ucacaacaaacaauuccuccaucugcuaaguauggugggcggcauacagugacuaugaucccaggggauggcaucggcccag

agcucauguugcauguuaagucuguauucaggcaugcaugugugccgguggacuuugaagaggugcauguaagcuccaacg

cugaugaggaggacauccgcaaugccaucauggccauccgccggaaccguguggcccugaagggcaacauugaaacaaauca

uaaccugccaccaucccacaaaucucgaaacaacauccuucgcaccagccuagaccucuaugccaacgucauccacuguaaga

gccugccaggaguggugacccggcacaaggacauagacauccucauuguacgggaaaacacagaaggcgaguacagcagccu

ggagcaugagagcguagcaggagugguggagagcuugaagauuaucaccaaagccaagucccugcgcauugcugaauaugc

uuucaagcuggcccaggagagugggcguaagaaagugacggcugugcacaaggccaacaucaugaaacugggugauggacuc

uuccuccagugcugcagggaaguagcagcccacuacccucagaucaccuuugacagcaugauuguagacaacacaacaaugca

gcugguaucccggccucagcaguuugaugucauggugaugccuaaucucuaugguaacauugucaacaacgucugugcagg

gcuaguuggaggcccaggccuuguggcuggggccaacuauggccauguguaugcaguauucgagacagcuacaaggaacac

aggcaaaaguauugccaauaagaacauugcuaacccgacugccacacugcuagcaagcugcaugaugcuagaccaccucaagc

uccacuccuaugccacuuccauccgcaaagcugucuuagcauccauggacaaugaaaauaugcauaccccagauauuggagg

ccagggcaccacaucccaagccauccaggacaucauucgucauauccgcaucauuaauggacgggcuguggaggcuuagcua

ucccuacaguuuugcucagcuugucuguaggacucucuucucacuuuagcacuccagcuagcuugggggacaggacccaga

auaaagccacuucuguuccagaaaaaa

198
AW125346
uuuuuuuuuuuuuuuuuguucuuaauagaaaacuuuauuuucacugauaaugucacugua

acauaauuucauagcagaccugugcaaaagaucccacaucaccaaugucuccaagagauu

ucacacacuucugggcaggacgcacagcucugcccccacccccguguugacagucaacau

uuuacccccgcuaugaguacagaaaggcgaggcaucauaacgaagccgccugaaggcagc

gugagcugaagucggacgcuugccaccucugaaugaauggucaccacagcaacagcacau

gguugccucagugugcucagggugggucuuugaaaaaacgucccacuauguaaauaugcu

gcacuuaucccuucaacauugu

199
X61232
See above (same Accession Number).

200
D20333
gauccuguauauguguguuuugggggagcuaugauaaguuuuauggcaaacgguugguau

uguuaacuuuuuauugucaucaaaaguucauaaaaguccuauuaauccccauauucunnn

ncugcccuuaacucugguauacaccaaaaagaaaucuuuacuuuccuuguuuuaucauua

uaaaaauaaaguauuuugcuaguauggaaa

201
AB025218
aguccgcgucccggcgucggcccgucccgcaccauggugacgcucgccgagcugcuggcg

cugcuggccgcgcugcuggccacggccucgggcuacuuugucagcaucgacgcgcacgcc

gaggagugcuucuucgagcgggucaccuccggcaccaagaugggccucaucuucgaggug

gcggagggcggcuuccuggacaucgacguggagaucacaggaccagauaauaaaggaauc

uauaaaggagaccgggaguccagcgggaaguacacauuugcagcccacauggaugggaca

uacaaguucugcuuuagcaauaggauguccacuaugacuccaaagauaguaauguucacc

auugacauuggggaggcucccaaaggacaagacauggagacagaagcucaucagaacaag

cuagaagaaaugauuaaugagcuggcaguggcaaugacagccguaaagcacgaacaggag

uacauggaaguccgggagagaauacacagagccaucaaugacaacacaaacagcagagug

guccuuugguccuucuucgaagcucuuguucuaguugccaugacauugggacagaucuac

uaccugaagagauuuuuugaaguccggaggguuguuuaaaaggccuuuuccuguugaucc

caaauucaugauuuacu

202
U84411
Sequence below.

gcauuggcucugggcugcggccggcucggcgacgcuccucgggcagcucacugcauggucgucuggugcccccgccgccug

cauccccgccgccgccccgcgacgcccaccgccgccugcccugccgccgccgccugcgccgccucgggaccggcuguaugauu

aggccacaaucuucaaugaguagacauauuccucaguucugugguguucucggucacacauuuauggaguuucugaagggc

aguggagauuacugccaggcacagcacgaccucuaugcagacaagugaacuguagaaauucauuacuacuccaccaagaaacc

cccauaagaguggauaaccuggacacaggcguguugaauugaaaucugcacagcauuugagaagagcucagaccuggauggg

guaaaccucagugccacuuccuuuguauugccucuaguauuacugggauugaagagucacugcuucuuguuuaggagguuc

auuucauuggcccguuucucccaauuucauacucaagcacugagaauuucaaguggaguauaucgaauaucgaaguagacu

ucagguuguuuuuugguuuuguuuuguuuuuuuuuuguuuugguuuuuuuuuuuuuuuucuguuuugguuuaaaucau

uucuguauucaauuuuuuaauucuuucauaacccuauuggguguuuuuuuaaacuaaauuaacauggcucgaaugaaccgc

ccugcuccuguggaagucacauacaagaacaugcgauuucuuauuacacacaauccaaccaaugcgaccuuaaacaaauuuau

agaggaacuuaagaaguauggaguuaccacaauaguaagaguaugugaagcaacuuacgacacuacucuuguggagaaagaa

ggcauucauguucuugacuggccuuuugaugauggugcaccaccauccaaccagauugucgaugacuggcuaagucuugug

aagauuaaguuucgugaagaaccugguugcuguauugcuguccauugugucgcaggccuuggcagagcuccggugcuugu

ugcccuagcauuaauugaagguggaaugaaauaugaagaugcaguacaauucauaagacaaaagcggcguggagcuuuuaac

agcaagcaacuuuuguaucuggagaaguaccguccgaaaaugcggcuccgcuucaaggauuccaauggucauagaaacaacu

guuguauucaauaaaacuggggugccugaugccauugccuuggaaguggaacuucagaugggaccugauuugucaugcaua

uuacccaaugugucggcuuacugaauaagucuacugcagcuccacaggaauacugaaaaaccagucuuaccaggccacaagu

uugacagaauugcaaccucuauauuugggcuaugaucaacauguuuggacacuuagcaaaagauuuuugcuguucagcauu

uaaaaugugcuuauuauuuguaccaauugaccuuuccuaaaauaagguauugaguuaugucauuaaauguacuccugugcc

agaauauuauuagucuauaaggaauuuagaaggauuaggugccaaaauacccagcacaauacuuguauauuuuuagcaucau

acagaaccaaaauugcaggaacugagaacucucagaccauccaugguguauuccuucagucauuucaaacacugcagggcuc

cucucguuaucugccugcucacucuguuuacaucucccacacuuaugccagaauacgucagguuugcuuagccauccuuua

uuuuuuuuauuuuuuuuuuuaacuaagucuugcgcugauuauuuaauaugucugucucauuuuguuuuguuuugggaaa

ccucugucugaaaaaucaacuuuguuacagaagcacauaucuucaacaaugucuccagacaaaaagccuuauaguuaauuua

auguuugcacucagaagugcaaccuaacagggagggccugaaaaagaaacgagaggaggcuauuaaauauuuuuaguaauau

guugccuuugucaugugcagaacauguagaguaugcucuuaauuuaguaaauauuuuuaagacauagagauacauguguag

cuaacccauucuuauucaaaauucuggaauuuuguguuuuccnauaccuaucaggaaguuuccagcuuguuugaauuaugg

cuuuccucuucccaaucucuugcaaaaaagacaaagugggaugaaucugcuagugaacugagcagaaauguuuuauaacgcc

uuuugagcuauguaacuuaauaauuggauacuugaucauuuguuuuauuauguaaucggauaaaauggugauguguauua

aaguuaguucaaccauauauuuauacugucugggaaugugugguuauaguucugugggagaaauaguuugucaguguuca

ccagcuuguaaaaacuuaguaugagagcuucaacauuuaaauaaaugaugaaccgcauucgucacugaggacacuuuugccu

aaaauuaacuuaauuuguagaaaacaauggauucaguuaauaucauuucaauuuauggaaaaaauuguuaggguugccaag

ugcuuuuuauuaaaaguuucucuuuaaaggucuagauaauugugaaucaguugaauguugggcaccgaggggaaacaguuu

guaauagaugaucuagauuuuucaguucaguuccaucagucacuuguagcucugcaauuuccagaccaguuuucucauuuu

uaaguucauuacaugccuguauauauuuugaaauuaacuugaaccugaguauuuggcacaugauggcuuaauaaauuuuaa

cuuuc

203
M62362
Sequence below.

acgcuccccaaccuccaccuccccucgcucggccucuauaugcucccgggcucccuaguguuggcuggaagugggugacuua

gaggcuuaaaggaggggcgccuaaccacggaccacgugugugcgggggcgacagcgccgccgggguggggcugagcgcugc

aagccggguucgccuugcagcgcaggagucagugggcguugcgccacgaucucucuccacuagcacuaugcucccgccccac

ucaccgccuuggaaagucacaggagaaggcgggcucuaagacccagcaggcaccauccuacuggcgccuucgauccgagaccc

guuuggacaccagggggcgaugccgacccucuauaaaagcgguccccgcgcgggccuggccauucgcgacccgaagcugcgc

gggcgcgagccaguuggggcacugggugggcggcggcgacagcggcgccacgcgcaggcuggaggccgccgaggcucgcca

ugccgggagaacucuaacucccccauggagucggccgacuucuacgagguggagccgcggcccccgaugagcagucaccucc

agagccccccgcacgcgcccagcaacgcccgccuuuggcuuuccccggggcgcgggccccgcgccgcccccagccccaccugc

cgccccggagccgcugggcggaucugcgagcacgagacgucuauagacaucagcgccuacaucgacccggccgccuucaacga

cgaguuccuggccgaccucuuccagcacagccgacagcaggagaaggccaaggcggcggcgggccccgcggguggcggcggu

gacuuugacuacccgggagccccggcgggccccggcggcgcggucauguccgcgggggcgcacgggcccccucccggcuacg

gcugugcggcggccggcuaccuggacggcaggcuggagccccuguacgagcgcgucggggcgcccgcgcuacggccgcugg

ugaucaaacaagagccccgcgaggaggacgaggcgaagcagcuggcgcuggccggccucuuccccuaccagccaccgccgcca

ccgccaccgccgcacccgcacgcgucucccgcgcaccuggccgccccccacuugcaguuccagaucgcgcacugcggccagac

caccaugcaccuacagccuggccaccccacaccgccgcccacgcccgugcccagcccgcacgcugcgcccgccuugggugcug

cgggccugccuggccccgggagcgcgcucaagggcuuggccggugcgcaccccgaccuccgcacgggaggcggcggcggugg

cagcggugccggugcgggcaaagccaagaagucgguggacaagaacagcaacgaguaccggguacggcgggaacgcaacaaca

ucgcggugcgcaagagccgagauaaagccaaacaacgcaacguggagacgcaacagaaggugcuggaguugaccagugacaa

ugaccgccugcgcaagcggguggaacagcugagccgugaacuggacacgcugcggggcaucuuccgccagcugccugagagc

uccuuggucaaggccauggcaacugcgcgugaggcgcgcggcugcgggaccgccuugggccggcccccuggcuggagaccca

gaggaugguuucgggucgcuggaucucuaggcugcccgggccgcgcaagccaggacuaggagauuccgguguggccugaaa

gccuggccugcuccgcguguccccucccuuccucugagccggacucggugcgucuaagaugagggagucaggccguggugg

uuucuccuugagaccgagagacuuuuccgcggagcugagcugggggcccggcaguacuaguauuaaggaaguaaccuugug

ccuuggauacucaaaacucgcuccuuuuccuaccgaguagggggagcaaaaaugugccuugauauuuuauuuggaggauuc

cugcuuccucucgggccucagcuggcccccgugagaaaaaugaagggugcaggcccagggcaggaggaagauacaggaagcu

gagaucccggcagugcccugagcugccccucagucccugucuuuagaggggagggacuuagguguuggggauuugagucug

uguccucacccccagcuacagggagguggagggcuccuaaucccuugcuuuuugcaccuccaccuacauccccccccccccac

ucagcuuacaacaggccagguuuccugggugaguucauggagaaugggggcaccacccccagucagacagaaagcugaguug

ugaguuagccaugugguaggagacagagaccuagguuucugggcuuuguggggugggggauaggaggacacggggaccau

uagccuuguguguacuguaugucgccagccgcuguugcugaaggaacuugaagcacaaucgauccaucccagagggacugg

aguuaugacaagcuucccaaauauuuugcuuuaucauccgauaucaacacuuguaucuggucucugugucccagcggugcc

uugugcaauggcagugugcacgucuaugcuaaaccaccauuuuauuuggucuuuuguuuuguuuugguuuugcucugauu

cuugccaaacugagacucuucacuaacggcugggggaaggagcugagugaggcucucauucuuuuugguuuagggauguu

uggguuuuuucgucugccucccagaggaccaaugaaaugaagugggcuucccccucuccccuaguuguccaaggguguaug

uaguagugggucuuagcuuccuccggcuaagacuuaggcuuccccacccacccaaccccauccccaacggcccuggcucugg

gucuggaaagaaggccaccuccagccaguucauacacacaccccuguggcugggagcagggcuggaccgcuuccuucucuuc

uuuuuuuggggggggggacacaaaguuucaugcuagaugucguauguauuauaucuauaauauaaacauaucaaacucaa

204
AA032310
gaagcucagugucgugaaauggaaaccaaaccuuggagccaucgcugaguauaaaaaaaa

ggaagauuuauauucngcaaagaguagccgaacuggacaaaauuacuucugaaagagaua

auuuuagacaagcauaugaagaucuucgaaaacaaaggcugaaugaauuuauggcugguu

uuuacguaauaacaaauaaacuaaaagaaaacuaccagaugcucacauugggaggagaug

cugaacuggagcuuguggacaguuuagauccuuuuucugaaggaaucauguucaguguuc

ggccaccuaagaaaaguuggaagaagaucuuuaaccucucaggaggcgagaaaacccuua

guuccuggccuuaguguuug

205
M94087
Sequence below.

gccgguuugaguugugcgcucgggugucccuuuccucuuccccucccgcagggcuugcggccaccauggcguauuagaggc

agcagugccugcggcagcguuggccuuugcagcggcggcagcagcaccaggcucugcagcggcaacccccaccggccuaagc

cauggcgcucuucacgaaauccagcagcaguguugcuguaacggacaaagauaccuucgaguuaagcacauuccuggaaucc

agcaaagccccacaacaugaccgagaugagcuuccugaacagcgaaguguuggcgggggacuugaugucccccuucgaccag

ucggguuugggggcugaagaaagccuaggucucuuagaugacuaucuggagguggccaagcacuugaaaccucauggguuc

uccagcgacaaggcgggcuccucggaauggccggcuauggaugauggcuuggccagugccucagacaccggcaaggaggaug

ccuuuuccgggacagauuggauguuggagaaaauggaucugaaagaguuugacuucgaugcucuguuucgaauggaugacc

uggaaaccaugccagaugagcucuugaccacguuggaugacacaugugaucuuuuugccccucuaguccaagagacuaauaa

ggagcccccucagacagugaacccaauuggccaucucccagaaaguuuaauaaaagucgaccagguugcccccuuuacauuc

uugcagccuuuccccuguuccccagggguucugucuuccacuccagagcauuccuuuaguuuagagcuaggcagugaaguu

gauaucucugaaggagacaggaagccugacucugcugcuuacauuacucuaaucccuccauguguaaaggaggaagacacuc

ccucugacaaugacaguggcaucuguaugagcccggaguccuaccugggcucuccccagcauagccccuccaccuccagggc

cccaccagacaaucugccuucuccaggugguucccgugggucuccucggcccaaaccuuaugacccaccuggaguuaguuug

acagcuaaagugaagacugagaaauuggauaagaagcugaaaaagauggagcaaaacaagacagcagccacuagguaccgcca

gaagaagcgggcugagcaggaggcccucacuggcgaguguaaggagcuagaaaaaaagaaugaggcucugaaagagaaggca

gauucucuggccaaggagauccaguaucugaaagaccugauagaagagguccguaaggcaagggggaagaagagaguuccgu

aauaggguagucaggugcuuugugcuuguacauagucuuguguugcuguguuugcuguaauaaauuauuuuguagugaaa

gu

206
AI847609
uuuuuuuuuuuuuuuauguagggaaguucauauuuuauuuguccagugacauuuuuuac

aguugaauacaaguuaaaggccugcuugcacaccaaagccagguccuuugggugguucag

ucaaagaaguaaggccuccagcuggcucacaacagaagcggccacuccuuggcccugguuu

gggaacuuuuccagcuuugaguucaucaauaaucucuucaauauccuugggugucagauc

cucauaguaguugucauuuauuugaaccaucggugcauuuacacaggccccuaaacauuc

cacuucuauaagagugaaaaguuugucagguguagucucuccaaccuuuauuccaa

207
AI853294
uuuuuuuuuuuuuuuuuggggugaauauagccaaguauuccauuuauuaacaaaauagu

cuuagcaagggagagcucuguucaccccacaagaggccccgcagccgaggccggcccgaag

ccccagcgcugcugcguaagaccgggagggagggaagguguuggggagaagacuuguauu

aagucuuuaauccuagccaccgcaggaacccacggaaaccuaaugccagcuuuggcgauu

gcuggcucaggucugggacauggcgaagggagugcucugauccuagggcucccugagucc

ccagccugcccccaacagagcuccuaaaguugucuggucugcugacuugaggacugguaa

gcuuuggagggauccaucaaggauuccccgaccccaccccuaucgccagggga

208
M33934
Sequence below.

ccucugcggcgcgguccucggagcggcgcgguucucggagccacgcgucugucuuccuccguggucauggcggacuaccug

auuagcggaggcaccucuuacgugccggacgacgggcucacagcgcagcagcucuucaacugcggggacggccucaccuaca

augauuuucucauucuuccuggguauaucgacuucacugcagaucagguggacuugacgucugcucuaacuaagaagauua

cacuaaagaccccauugguuuccucacccauggacacugucacagaggcuggaauggccaucgcgauggcgcuuacaggagg

uauugguuucauccaccacaacugcacaccugaauuccaggccaaugaaguucggaaagugaagaaauacgaacagggauuc

aucacugaccccgugguccuuagccccaaggaucguguacgcgauguuuuugaggccaaagccaggcauggcuucuguggu

auccccaucacagauacaggccggauggggagucgauuggugggcaucaucuccucaagggacauugauuuccucaaggagg

aagagcaugaccgguucuuggaagagaucaugacuaagagggaagauuugguggucgccccugccggcgucacucugaaag

aggcaaaugagauucugcagcgaaguaaaaagggaaaguugcccauugugaaugaaaaugaugagcugguagccaucauugc

ccggacagaccuaaagaagaaucgugauuacccccuggccuccaaagaugccaagaagcaacugcuguguggggcagccauu

ggcacucaugaggaugacaaguauaggcuggacuuacuggcccuugcugguguggauguagugguuuuggacucuucccag

ggaaacuccaucuuccaaaucaauaugaucaaauacaucaaggagaaguaucccagucuacaggucauuggaggcaauguag

ucacugcugcgcaagccaagaaccucauagaugcagguguagaugcuuugcgagucggcaugggaagugguuccaucugca

ucacccaggaaguguuggccugugggcggccccaagccacagcaguguacaaggucucugaguaugcccgucgcuuuggug

uuccuguuauugcugauggaggaauccaaaaugugggucauauugccaaagcuuuggcucuuggggcuuccacagucauga

ugggcucccuccuggcugccaccacugaggccccuggcgaguacuucuucucagaugggauccggcugaagaaauaccgagg

uauggguucucuugaugccauggacaaacaucucagcagccagaaccgauacuucagugaagcugacaaaaucaaaguggcc

caaggaguuucaggggcagugcaggacaaggggucuauccacaaguucguuccuuaccugauugcuggcauccagcauucc

ugucaagacauuggugccaagaguuuaacccaagucagagccaugacguacucgggggagcuuaaauuugagaagaggacau

ccucugcucagguggaagguggcguccacagccuccauucguacgagaaacggcuuuucugaaaacagauccaguauaugcc

uugaauuuuucaauaaaaguuugggaaaaaaaaagugaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

209
X16202
gugugggugcagagcuggggucagggaaagcuggagccuuuugcagacccugagcugcuc

acggcugagagcuggggucauuacccucaccuucauuuccuguaccuguccuucccagag

ccuccuccauccacugucuccaacauggcgaacguagcuguucugguuguccuuggagcu

uggccaucauugcagcugugguggcuuuugugaugaagagaaggagacacacagguagga

aagggcagagucugaguuuuu

210
AI661431
acaggaggggaaggccaaagcaagaaugaaagucccccgccccguaucaccacgggcacu

cggggucacccucaggaacaugcagucucugcacgugaggaaagaaacacgcagagaugg

acgagcacuuuuacacccuaauaaaauuagaugcacuaaccacagaccccccu

211
AI839109
uuuuuuuuuuuuuuuuuaaaaaaaaaaauggcaucuuuuauucaucaaucccuguuacac

acugaaauacaugcaucuuucuuauguuacuuagcaacguccuuucuauccuuucaccca

uaaaucagucugaugaauucaucuuuaaauucaagaaguuuuucuuuuugaaacgcuacu

uacauuuuauugucucaauaucaaagccaaucuagagauuuauucuuccuacaggugaaa

uagauguuaauacgggaacagucaguacauguucaagaugacaucaaaguuaugcccuaa

gcagauauuucaaggcaauaucaugccacuagcucugagacucuaaguaucacugauagu

acuaaaagguagaagucagcuucaaaaacacacucuugcaauggacacugcucaugaugu

cuaagauuguucacucccacagucaugauuucagaugcacaguuuuuuuugcuuuccuga

gcauucgguuugac

212
AI849135
uuuuuuuuuuuuuuuuuaagagugucaccaaagcuuuauuuacaugcgucaucaucucuu

uuacaaacuagauuaugguuuuaaauggaauacacaggcaauaucuacaaacgccacggg

aaguacgcaccuccauuccaccgggaaggggcagauucccaaaucaaacugguuuugauc

cuugagaagaaaggcggcagagcuaacucacggcagcguaugguuagacaagguccucag

uacccagaaugcagcaggauugcgucugccucaaaccagacgaccaacugcugcaggugu

uuaaacauggccacgcgccacacgaaauucuaguuugugugggguagaagcaagaaaaaa

aaaaaaccauggcgccucgugccg

213
M32459
gguccggauaguaaacugcucccuuacaucuccuuaaauauaaaguaaggaaaaagaaaa

aacucaguucggguaaccaaguucaacaaguaauccuuggggccgcugugguaucgccaa

aaucuacauaguaucucuuauuaaaauguuuugacgaaaauguaacaauuacgguacuua

augguaacaauguggcugaggaagcaauaguuaacaaagaggagcuaagcuaugcaacaa

accagauuucuauuggucacaaauuugaaguugagaccuguuauccaauuaccaaguacu

uccgcauacaucaucauaggcauuugaagauuucaaccaaucaggagcauguuccuucua

uaaaggaacccagaaccuaaccucugcauuuccuauuucuuuguagaaauggcucguacg

aagcagaccgcucgcaaguccacuggcggcaaggccccgcgcaagcagcuggccaccaag

gccgcccgcaagagcgccccggccaccggcggcgugaagaaaccucaccgcuaccguccc

ggcaccguggcgcugcgcgagauccggcgcuaccagaagucgaccgagcugcugauccgc

aagcugccguuccagcgccuggugcgcgagaucgcgcaggacuucaagaccgaccugcgc

uuccagagcucggccgucauggcucugcaggaggcgagcgaggccuaccuugugggucug

uuugaggacaccaaccugugcgccauccacgccaagcgugucaccaucaugcccaaggac

auccagcuggcccgccguauccgcggcgagcgggcuuaauaggcacgcuuucuacacugg

cacguaaaccaaaacggcucuuuuaagagccaccuccauuauccaccaaagaugcuugaa

guacaaguugugagaguuuucuaggguuuccuauuauagccuuucuugacaaugugagca

ccacccgacgaagcagucugag

214
AI841389
uuuuuuuuuuuuuuuuuggacuucugcggcuuuuauuuuugcauguaaaccacugggggg

agggggaucuugauggugggcacccuagagauuacacuggaguuccgagggcuccagaca

cuagcugggaagucaggugacagaaacaaugauucagaccaaucacaugauugcaaaacu

gggucuccagcagggauucugguggucagguguggaugccuaaggaagcagugacauggg

aggggcacgcacugggcuggccuugagcugcugggaugacaucagggauagaggaccuag

cagcugguggcuccagggaucuccgguccaugcuuuauuuggccaggggguuccugaagg

accugccagcaaacuuggcuuugcugcccagcucuuccucaauucugaggaucugauugu

acuu

215
X03039
Sequence below.

auucuaaggaucaugucugcgagucaggauucucgauccagagacaauggccccgacgggauggagccggaaggcgucaucg

agaguaacuggaacgagauuguggauagcuuugaugacaugaaucucucagagucccuccuccgugguauuuaugccuaug

guuuugagaagcccucugccauccagcagcgagcuauucuuccuuguaucaaggguuaugaugugauugcucaagcccagu

cugggacugggaaaacagcuacauuugccauaucaauucugcagcagauugaauuagaucuaaaggccacucaggcuuuggu

ucuggcacccacacgugaauuggcucagcagauacaaaaggugguuauggcauuaggagacuacaugggugccucuuguca

ugccugcauugggggcaccaaugugcgugcugaggugcagaagcugcagauggaagcuccccauaucaucguggguacccc

uggccggguguuugacaugcuuaaccggagauaccugucccccaaauacaucaagauguucguacuggaugaagcagaugaa

auguuaagccgaggguucaaggaucagaucuaugacauauuccagaagcucaacagcaacacacagguaguuuuguugucug

cuacaaugccuucugauguccuugaggugaccaagaaauuuaugagagacccuauucggauucuugucaagaaggaagaau

ugacccuggaggguauccgccaauucuacaucaauguggaacgagaggaguggaagcuugacacauugugugacuuguaug

agacgcugaccaucacccaggcagucaucuuuaucaacaccagaaggaagguggacuggcucaccgagaagaugcaugcccga

gauuucacuguuucugccaugcacggagauauggaccaaaaggaacgagaugugaucaugagggaguuccggucuggcucu

agcagaguauuaauuaccacugaccuguuggccagaggcauugaugugcagcaggucuccuuagucaucaacuaugaccuuc

ccaccaacagggaaaacuacauccacagaaucggucgagguggucgguuuggucguaaggguguggcuauuaacaugguga

ccgaagaagacaagaggacucuucgagacauugagacuuucuacaacaccuccauugaagagaugccccucaacguugcugac

cucauuugaggggcuguccugcgaccuggcccuagcccaggguucaguccugggguggggcuaaggaagagcuggaggggg

gaggggagggagccaagggauggacaucuuguuuuuguuuuggcuuuuuuuuuuuuuuguuucaguuuuuuuucucuau

gaauaaaugucacuuuuugaggc

216
AW049795
uuuuuuuuuuuuuuuuugccaggauauauuuauuacugaaaguacaagcaacugagguuu

acccugggaacacccacaaugaaacguguaucuucccuguuucucagaugcugccuccuu

ccacagagugaguuuucguuuaaaacucauaaugaggagaaggcagggggcuccaccccu

uuccuguucaaucugaagacugaauugggcuacacugggauggagauuucaggugcugca

ggucagugucaaccaaggguucgugugucaggaacucuggcugguaagaugacacaaagg

cuucaugcugaagcucagggagguccagggagccuggcagaauggaaucaucauggucau

caucaaacgucugugucuggaaggcuucaaggcucauaauugcaucauucucuggcaguu

ccugagagagcugccccuuccuggguuugcacgcaucaaauuucacccacugguaauuga

cacaguuuugagcuucgggacaacucuuaaucagguuguggaugguuggaugagaaaacc

caaagaagucggcaccgcauga

217
D87691
Sequence below.

auuguaacagaagaaggaaaggaaaagaaaguuaacauugacuuugaaccuuucaaaccaauuaauacaucauuguauuugu

gcgacaauaaguuucauacagaggcucuuacagcguuacuuucagaugacagcaaguuugguuuuauuguaauagacggaa

guggugcucuuuuuggcacgcuccaaggaaacaccagagaaguccugcacaaauucacuguggaucucccaaagaaacacgg

cagaggaggucaaucagccuugcguuuugcccguuuaagaauggaaaagagacauaacuauguucggaaaguagccgagacu

gcugugcagcuguuuauuucuggagaccaagugaauguggcugguuugguuuuagcuggaucagcugacuuuaaaacuga

acuaagucaaucugacauguuugaccagagguugcaaucuaaaguuuuaaaauuaguugauauauccuaugguggugaaaa

uggauucaaccaagcuauugaauuaucuacugaaguucucuccaacgugaaguucauucaagagaagaaauuaauaggacga

uauuuugaugaaauuagccaggacacaggcaaguacuguuuuggaguugaagauacacuaaaggcuuuggaaaugggagcu

guacaaauucuaauagucuaugaaaaucuggauauaaugagauacguucuucauugccaaggcacagaagaggagaaaauuc

ucuauuuaacuccagaacaagagaaggauaaaucucacuucacagacaaagagacuggacaggaacacgaacugauagaaagc

augccucucuuggaaugguuugcuaacaacuauaaaaaauuuggagcuacacuagaaauugucacagauaagucacaagaag

gaucacaguuugugaaaggauuugguggaauuggagguaucuugcgguaccgaguagauuuccagggaauggaguaccaag

gaggagaugaugaauuuuuugaccuugaugacuacuagguagucgacauggguccggcaaccgugccucacccuccagcau

ucaacccaaggagcauacccgugguggaguccaacagaucccugccuuacaauuggagcauuuccagaacuuaauccgugag

cauuggauacugaaaagaaaagugaaacaaaaccagacccaacccuacacuuugguuugucguggugucagcgcagcagccg

acaacuaagucucu

218
AI117211
cagaggagucauuguugcugugguggcuuuugugaugaagaggaggagaaacacagcgua

agccagcugccuggaguggacuaagugacagacaaugucuucacacaucuccugugacau

ccagagcccucaguuuucuuuagucaaguaucugauguucccugugagccuaugggucaa

agugaagaacugugcagcccagccugcccugcacacagaacccugucccugcacugcccu

ggguucccuuccacagccaaccuugcugcuccagccaaacacugggcgacaucugcaucc

ugccagcuccaugcugcccugagcugcagcuccucacuuccacacugagaguaagaaucu

gaaugggaccuugauucuuaacauccugaccgaggguugauuucuuguuaauuucaugga

uugagaauacuuagaguuuugguuugucuugauuuuuuuucaag

219
Y00520
ugaauaaaaacgaggagccgaagauucuagggggcuacagcugcgcuuuugcagcacuga

acaugguuccggguacucaagauauugcguuuguguuuggagagguguagauuguagauu

ccagccgagaagaccaggaaaagauaaggauaaagaaugucauauaucucaggagcuaga

ucacuucccgaugaacaaguaagaauugccucaacaaaaauggauggaauuggaccgaaa

aaagccauucagcuucguuaucgauuagguaucagugggaacaucaagaugaaugaguua

acuaaguaucagaucgaccaaauugaacaaaugauagcucaagaucauguuguucauugg

gaauugaagaggggagaacgagcagacaucgaacgauuaauuucuauuucucguuaucgu

ggaauucgucaucaagauggaucgcccuuacgcggucaacgaacucauacuaaugcaagg

acugcucgcaagcaaauucggaaaugaaagaaggcuaccgaaagaacaagcaacggauuu

cgcgcucaucccuugcuaaagcgcauacguuuucuugcuccuugguacuugucugaucaa

ucacacuguucauuaguucacuugauuuuucguucgaugucuugaaccgcuuacuaauca

cguauacguauaguaggcccccuucgccacuccacgucuggcccgucuuggucucgcuca

cuucgcccgccuaucguaucggcucggcuucguccgucaagcgacagcuucugccucuga

cggcuucacuaucgcucaugacugguaguacucuauguaguagucggccuuuguuaagcuu

220
AA638002
uauaaccauguuagaagcggaaguuggccugaaaaccugaggcuuaggcuucauagcugg

gcuguagauuggauuuaaacccaguuggagugcaaagucauggugugcucaaggugauga

cagugaacagaguaug

221
Z22661
caugggccuccugagaga

uccuuagauccagguuagugcauaggaaaguguccccccacuaccuacagcuaagggauu

gggguggugggaucaugguggagggccguggugaauacuagcgaugucccccgcuacccg

ugcgucugccuccagggugccccuccaaccaggaugaggcucuucaucgcucuuccuguc

cugauuguggucguagccaugaccuuggaagguaagaaagagccuuggaagguaagaaag

augcuuggaagugugaaguuggccuugugccugcggcccaggcuuagaagacccucgagg

agggcucugaggucccuuucugugucaucauuccacuaccgcccucccaucgucccccau

cccaccugccaggugccuuauuuuugugucaaagugggugcugaaggaggcaacucuguc

cagaaaagacgcaguaaccaaugaccuaggauaccacccuuuggaauuggcuaaucuucc

uagaaggggcggacgguaaaaacaaggaggugagaggugcaguaaaaucaaguguccaau

acccucccccaugcuaaugaguuugcucgcaacccucucgcggcaggcccagcccccgcc

caggcggccccggauuuguccggaacauuggagagcauaccggauaaacugaaggaguuu

gggaacacuuuggaagacaaggcccgggcagccauugaacauaucaaacagaaggaaauu

uugaccaagacccg

222
X99644
Sequence below.

cagcgccuggggcgcggcgggcgucggcccaggagacgcguggcggcgcucggccucgcggcaucggcggcugccuggccg

uuggcggcgagcgcacuugcgccugcgcagcgggguccgugccccuccuccccugggcggcccccccacccccccggcggcg

ugugaauggcggccucggcggcagcgacugcagcggccucggccgcgacggccgccucggcggccucugguagcccaggguc

gggcgagggcucggcgggcggugagaagcguccggcugcuuccucagccgcggcggccucugcagccgcgucguccccugc

ggggggcgguggcgaggcgcaggagcuucuggagcacugcggcgugugucgcgagcgccugcggcccgagcgggauccucg

gcugcugcccugucuacauucggccugcagugccugccugggccccgcuacacccgccgcagcgaauaauucgggggauggc

ggcucggcgggcgacggcgcuaugguggauuguccagugugcaaacagcagugcuacuccaaagacaucguggagaauuau

uuuaugcgugauaguggcaguaaggccucuucugauucccaggaugcuaaccagugcugcacuagcugugaagauaaugcc

ccagccacuagcuauuguguggagugcucugaaccacuuugugagaccuguguggaggcucaccagcgggugaaauacacca

aggaccacacugugcgcuccacaggaccugcuaagacucgagauggagagcgaacagucuacuguaaugugcacaagcauga

gccccucgugcuguucugugagagcugugacacacucaccugccgcgacugccagcucaacgcucacaaggaccaucaguac

caguuuuuggaagaugcagugaggaaccaacguaaacucuuggcuucacuggugaaacgucuuggggacaaacaugccacac

uucagaaaaacaccaaggagguucgaagcucgauccgccaggugucugaugugcagaagcgagugcagguugaugucaagau

ggccauucugcagaucaugaaggagcugaauaagcggggucgaguucuggucaaugaugcccagaaggugaccgaggguca

gcaggaacgucuggagcgccagcacuggaccaugaccaaaauucagaagcaccaggaacacauuuugcguuuugccucuugg

gcucuggagagugauaacaauacagcucucuugcucucuaagaagcugaucuauuuccagcugcaucgggcccucaaaauga

uuguggauccuguggagccucauggugagaugaaguuucagugggaucucaaugccuggaccaagagugcugaagccuuug

gcaagauuguggcugagcguccugguacgaacuccacagguccugggcccauggcuccuccaagagccccaggcccucuaag

caagcaagguucuggcaguagccagcccauggaaguacaagagggauauggcuuugggucagaugaucccuauucaagugca

gagccgcauguaucaggcaugaagcggucccgcucuggugagggagagguaaguggccucuuaaggaaggugccacgugug

agccuugaacgccuggaucuggaccucaccucugacagccagccaccagucuucaaggucuuuccuggaagcacuacugagg

acuacaaucugauuguuauugagcguggugcugcugcagcagcugcuggucaggcugggacugugccaccaggagccccug

gugccccaccccuuccuggcauggccauugucaaggaagaagagacagaagcugcuauuggagcucccccggcugcccccga

ggguccugaaaccaagccuguguugaugccucugacugaagguccuggugccgagggaccucgucuagcuucaccuagugg

caguaccagcucaggcuuggaggugguggcuccugagguuacuucagccccaguaagugggccagguauccuggaugacag

ugccacuaucugccgagucugccagaaaccaggugaccuggucauguguaaccagugcgaauuuugcuuccaccuggauug

ccaccucccugcccugcaggauguuccaggggaggaauggaguugcucacucugccacgugcucccugaccuaaaggaggaa

gauggaagccucagccuggauggagcagauagcacuggugugguagcuaaacucucaccagccaaccagcggaaaugugagc

guguucuccuggcccuguucugccaugaaccaugccgucccuugcaucagcuggcuaccgacucuacauucuccauggagca

gccuggugguacccuagaccugaccuugauucgugcucgccuccaagagaagcugucaccuccuuauagcuccccccaggag

uuugcucaagaugugggccgcauguucaaacaguucaacaagcugacugaggacaaggcagauguucaguccaucaucggcu

ugcagcgcuucuuugagacacgcaugaaugaugccuuuggugacaccaaguuuucugcugugcugguagaaccaccaccau

ugaaccuucccagugcuggccuaaguucucaggagcucucuggcccuggugauggccccugaagcuggggcucuugugguc

agcccaguccagcucuggucucuguauuuucaccccauacccuguccuuugguggccugacuccuguucuugcuggcccca

ucguccccucagucccucuucacaaaaugguuuuuacuucuguggauuuaauaaaaacuucacugagucaguuaaaaaaaaa

aaa

223
AI843895
uuuuuuuuuuuuuuuuuaaaaauaauuucauuuuuuaauauucuguacaaaauuucucaa

ccuaugaaaauaaaguuugcaaaagucaaaguaguacaugggccugcccuggagccaggc

ccagccggaucuacacuauguacaggucucccagggugagccucagcuagggaaaagcca

cuaaggugccuacagagcaagagggugccaucgggccagugcagccucugcaauuuccag

aucugccacuagaggucggcaugguccugauugcuugucaggcucacccucuggaagacc

acagccaaugacaaagguccucaagggaaagcuuuggggucuagcuggaagugacggugg

guccgccgcccaggcgcaggagcaucugcuggcaguccagcaguaaccggugaucgccaa

224
M38724
uccgucguaaccuguugaguaacuauggaagacuauaucaaaauagagaaaauuggagaa

gguacuuacggugugguguauaaggguagacacagagucacuggccagauaguggccaug

aagaagaucagacuugaaagcgaggaagaaggagugcccaguacugcaauucgggaaauc

ucucuauuaaaagaacuucgacauccaaauauagucagccugcaggaugugcucaugcag

gacuccaggcuguaucucaucuuugaguuccuguccauggaccucaagaaguaccuggac

uccaucccuccugggcaguucauggauucuucacucguuaagaguuacuuacaccaaauc

cuccagggaauuguguuuugccacucccggcgaguucuucacagagacuugaaaccucaa

aaucuauugauugaugacaaaggaacaaucaaacuggcugauuucggccuugccagagcg

uuuggaauaccgauacgaguguacacacacgagguagugacgcugugguaccgaucucca

gaaguguugcugggcucggcucguuacuccacuccgguugacaucuggaguauagggacc

auauuugcagaacuggccaccaagaagccgcuuuuccacggcgacucagagauugaccag

cucuucaggaucuucagagcucugggcacuccuaacaacgaaguguggccagaagucgag

ucccugcaggacuacaagaacaccuuucccaaguggaagccggggagccucgcaucccac

gucaagaaccuggacgagaacggcuuggauuugcucucaaaaaugcuagucuaugauccu

gccaaacgaaucucuggcaaaauggcccugaagcacccguacuuugaugacuuggacaau

cagauuaagaagauguagcccucuggauggaugucccugucugcuggucguaggggaaga

ucg

225
AW122989
uuuuuuuuuuuuuuuuuacuaggcaaagaauuuuauuaacccuuuccaaacuuuauuccc

aggcuucuucagcuuuauuugccgcaaagaaugaauuagguauagcgaaaacugaaaaga

gcugcaguguccgggggcuugggcuuaaaaauauuagagaucuagauuuuaucagaucca

uaauaaacaaaaaaauuuuaaaaagcagucaugauauaaaauagcagcuccuguaauuuc

ugcaaguaucaccuucuucagaaguugcuucaauucaguuugccucauucuuagaagccu

caucaaaauucuccaccagaucuggaacuucaucaucaucauccucuccaguagcaaggg

gugcuuuuccauccacagauuguuugggcagagcuucagccagucuccuuaaacuaguca

ggcugucugcaccaagcugguugaggaugcugggaagcauuucugucagcugcuuuguc

226
AI844810
uuuuuuuuuuuuuuuuuauucaugcuugccuagggauggggaauagaucauucaauaaaa

acauacaguaaaaacaggggguggggagggggaaggcuuaucauguacaauguuuaaacu

acaauagugauguaccuuaauuacuuccaugcacacaagucuaacauuacaaguuuuuaa

aaaauaaacaccauuaagacuucuaggagcauuuuauaauaaauuccuaauuuuuucuuu

guagauagaucaagcaccuccaaaauacagauuccuauacacagugagcacuuuacuuaa

cguacauggacagccucaggacgagcugacgucucggaucagcucggcaggcaacaaacc

auagugccaaauggaaagaagggcaguugcaaauaaacuuaaaacuaaguuaacuuuuau

aauuaaauacagaaaauauacugauuugcuaaaaauaaauaagaugugauguauuuaaca

cuucacuauaaagaaugaacaccaugacauccucgugccg

227
AA940430
agaagaaggaggagugggaccgcaagcaugaggaugcuaguagggaguaugagaaaggca

ugaaagaguaugaaggaggaagaggggacucaucuaaaagggacaagucuaagaagaaaa

agaaaguaaaagcaaagauggaaaaaaaguccacuccuucccggggcucgucauccaagu

cuucauccaggcaguugagugacagcuucaagagcaaagaguuuguguccagugaugaga

gcucuucaggcgagaacaagagcaaaaagaagaggaggcggacgaggacucugaagagga

gcuagccaguaccccuccaagcucagaggacucugccucgggaucugaugaauaaaggag

ggaauucccaccccgucacagcuccagucucucacauaguccuuggauucugugccaucu

gaguaacugcucuugguggcuuccacugcccugaggcuuugagggaag

228
M38381
Sequence below.

aucgucguaaucguuugcagacuucucgccgucgccuuguaagcuuugucuucgccuugcaagcuuugucuucaggguug

gaaagaugagacauucaaagagaacuuacuguccugacugggaugaaagagacugggauuauggaacauggagaagcagcag

cagucacaaaagaaagaagagaucacauagcagcgcccgugagcaaaagcgcugcagguacgaucacuccaaaacgacagaca

gcuauuaucuggaaagcagauccauaaaugagaaagcuuaucauagucgacgcuauguugaugaauacaggaaugacuacau

gggcuacgagccagggcaucccuauggagaaccuggaagcagauaccagaugcauaguagcaaguccucugguaggagugga

agaagcaguuacaaaaguaaacacaggagucgccaccacacaucgcagcaccauucacacgggaagagucaccgaaggaaaaga

ucgaggaguguagaggaugaugaggagggucaccugaucugucagaguggagacguacuaagugcaagauaugaaauuguu

gauacuuuaggugaaggugcuuucggaaaagugguggaaugcaucgaucauaaagugggagguagacguguagcaguaaaa

auaguuaaaaauguggauagauacugugaagcugcucaaucggaaauacaaguuuuggaacacuugaauacaacagaccccc

auaguacuuuccguuguguccagauguuggagugguuugagcaucgaggucacauuugcauuguguuugaacuucugggg

cuuaguacuuaugauuucauuaaggaaaacaguuuucugccguuucgaauggaucauaucaggaagauggcauaucaaaua

ugcaaaucuguaaacuuuuugcauaguaauaaauugacucauacagacuugaagccugaaaacaucuuauuugugaagucu

gacuacacagaggcuuauaaucccaaaaugaaacgugaugaacguacuauaguaaauccagauauuaaagugguggacuuug

gaagugcaacauaugaugaugaacaccacagcacauugguaucuacaagacauuauagagcaccggaaguuauuuuagcccu

cggguggucacagccaugugaugucuggagcauaggauguauucuuaucgaguauuaucuuggauuuacaguuuuuucga

cucaugauagcagggaacauuuagcaaugauggaaaggauucuuggaccacuaccaaagcacaugauacagaaaaccaggaaa

cgcagauauuuccaucaugaucgauuagauugggaugaacacaguucugcuggcagauauguuucucggcgcuguaaaccu

cugaaggaguuuaugcuaucucaggaugccgaacaugagcuucucuuugaccucauugggaaaauguuggaguaugauccc

gccaaaagaauuacucucaaagaagcccuaaagcauccuuucuuuuacccacuuaaaaagcauacgugauuuauaaacacagu

gcucugaaaggaaucuuacagacuguaucagucuagcuuuuaauuaaguuauuuuguauagcuuaauuuguaaaacauuuu

auguuuuuuagaugcuuuauuaaauacauggccaaaccaaauaacaucuuucaguaauuauagaaugauuuauuuggaaua

aaauuugugcuuaugaauguaaaaaaa

229
AF014371
ggacucgcgacaagcguccucagcgcgaagaggcggacucggaguccucgccuugagccu

ugcaucugagaaguuccagguacuuuguacaacugcaucccagaaccuguguguuuucag

caccuuuauaagugauggcugccaucaggaagaaacuggugauuguuggugauggagcuu

gugguaagacaugcuugcucauagucuucagcaaggaccaguucccagaggucuaugugc

ccacgguguuugaaaacuauguggcggauaucgagguggaugggaagcagguagaguugg

cuuuaugggacacagcuggacaggaagauuaugacugccugaggccucucucuuauccag

acaccgauguuauauugauguguuuuuccauugacagcccugauaguuuagaaaacaucc

cagaaaaauggacuccagaagucaagcauuucuguccaaaugugcccaucauccugguug

ggaacaagaaggaccuucggaaugacgagcacacgagacgggaguuggccaaaaugaagc

aggagccgguaaaaccugaagaaggcagagauauggcaaacaggauuggcgcuuuugggu

acauggaguguucagcaaagaccaaagauggagugagagagguuuuugagauggccacga

gagcugcucugcaagcuagacgugggaagaaaaagucugggugccucaucuugugaagcc

uugugaacgcagccucaugcgguuaauuugaagugcuguuuauuaaucuuaguguaugau

uacuggccuuucauuuaucuauaauuuaccuaaga

230
Z30939
uucaagaccgaccugcgcuuccagagcucggccgucauggcucugcaggaggcgagcgag

gccuaccucgugggucuguuugaggacaccaaccugugcgccauccacgccaagcguguc

accaucaugcccaaggacauccagcuggcccgucgcauucguggggagagggcguaaauu

aggguagugagugaauuuggaccccaaaggcucuuuucagagccacccacauuuucuaua

aaaggcuguauaucgauaagcuuuuauaaaccccacucagcaacucc

231
U28208
uuaugugauaaaaaaauucaacuugguauuaacuuaacuaagggccuuggugcuggugcu

uugccugauguugguaaaggugcagcagaagaaucaauugaugaaauuauggagcauaua

aaagauagccauaugcucuuuaucacagcagggauggguggugguacuggaacaggugcu

gcaccgguaauugcaaaagcagccagagaagcaagagcgguaguuaaagauaaaggagca

aaagaaaaaaagauacugacuguuggaguuguaacuaagccguucgguuuugaaggugug

cgacguaugcgcauugcagagcuuggacuugaagaguugcaaaaauacguagauacacuu

auugucauucccaaucaaaauuuauuuagaauugcuaacgagaaaacuacauuugcugac

gcauuucaacucgccgauaauguucugcauauuggcauaagaggaguaacugauuugaug

aucaugccaggacugauuaaucuugauuuugcugauauagaaacaguaaugagugagaug

gguaaggcaaugauugguacuggagaagcagaaggagaagauagggcaauuagugcugca

gaggcugcgauaucuaauccauugcuugacaauguaucaaugaaaggugcgcaaggaaua

uugauuaauauuacuggugguggagacaugacucuauuugaaguugauucugcagccaau

agagugcgugaagaaguggaugaaaaugcaaauauaauauuuggugccacuuuugaucag

gcgauggagggaagaguuagaguuucuguucuugcaacuggcauugauagcuguaacgac

aauucaucuguuaaucaaaacaagaucccagcagaggaaaaaaauuuuaaauggccuuau

aaucaaauuccaacauuagaaacaaaagaauaugcuucaacugag

232
AV218217
ugaucaggucacauuccggugccuuccacccccuauggcacgggcgccccgccuugccau

accacagcucccuccaggcuuagaccuggcuucaccgcauuucaggugcuauaccccccc

cugcuuuuccccccauugcccuuaaaugccccucggccccuccauccccccggaacaggg

uggcacuugccacucucaggaccaccuugccaaggagaauaaaccgaauccuguugcu

Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, anagen can be induced by activation of these transcripts, proteins, and pathways.

Example 9
Molecular Pathways Activated During Induction of Epidermal Cells to Differentiate into HF Stem Cells

The gene expression pattern of HF stem cells was analyzed as described in Example 8 and compared to non-bulge basal keratinocytes. 157 genes were differentially expressed in the HF stem cells, as assessed by microarray analysis and quantitative polymerase chain reaction (qPCR). A group of selected genes with increased expression in HF stem cells is depicted in Table 4. A group of selected genes with decreased expression in HF stem cells is depicted in Table 5.

TABLE 4

Genes up-regulated in HF stem cells. Numbers in parentheses are the

fold increase as determined by quantitative real time PCR.

Gene Name/

Protein name/
Fold

GenBk Acces #.
Incr.
Sequence
SEQ ID No.

Cell surface proteins

Cd34/Cd 34
43 (189)
uuuuuuuuuuuuuuuuucacucaucacguuuauucagaagagaauacac
233

antigen

ccaauccucucaucucuggaaaguuuuguuccuagccaucauuaagauc

AI847784,

aggaccccuguucuccccuuaaccccaggagaggaagcuuauagucuuu

AI173145

guagauauucugaaccucugaucacaaaggguuauaaaauagugaaggg

guuuggacuaggaaaggcacagacugaaaggaaucugccaggggacuga

ggccacagcucccccaggagucagaggaagggggaagucacguauuuua

uagaaggccaagggccucagagcaagaguauuccuuugaagagcuca

Calcium-related

S100a4/
35 (144)
ugguggagcaggucucaggaaucucuucgcuucagcuucaaucauggcc
234

S100A4

uguggucuggucgccagcaaccugaaucucaaaccuggggaaugucuca

(mts)

aaguucggggagagguggccucggacgccaagagcuuugugcugaaccu

X15986

gggaaaagacagcaacaaccugugccuacacuucaauccucgcuucaaug

cccauggagacgccaacaccauuguguguaacaccaaggaagaugggacc

uggggaaccgaacaccgggaaccugccuuccccuuccagcccgggagcau

cacagaggugugcaucaccuuugaccaggcugaccugaccaucaagcugc

cagacggacaugaauucaaguuccccaaccgccucaacauggaggccauc

aacuacauggcggcggauggagacuucaagauuaagugcguggccuuug

agugaagccagccagccuguagcccucaauaaaggcagcugccucugcu

Transcription Factors and related genes

Id2 helix-
11 (25)
gugguucuucggcgccagguucgcccgcuucugcccuuagguaacauuc
235

loop-helix

ucuaaacugcguuucucucccaaucuuuugcaggcauuuggggacuuuu

protein

ucuuuucuuuuuacuuucucuuuuucuuuugcacaagaagaagucuaca

AF077861

agaucuuuuaagacuuuuguuaucagccauuucaccaggagaacacguu

gaauggaccuuuuuaaaaagaaagcggaaggaaaacuaaggaugaucguc

uugcccaggugucuuguucuccggccuggacugugauaccguuauuuau

gagagacuuucagugcccuuucuacaguuggaagguuuucuuuauauac

uauucccaccauggggagcgaaaagguuaaaaaaaagaaaaaaaucacaa

ggaauugcccaauguaagcagacuuugccuuuucacaaagguggagcgu

gaauuccaggaggacccaguauucgguuacuuaaaugaagucuucgguc

agaaauggccuuuuugacacgagccuacugaaugcuguguauauauuua

uauauaaauauauauauauugagugaaccuuguggacucuuuaauuaga

guuuucuuguauaguggcagaaauaaccuauuucugcauuaaaauguaa

ugacguacuuaugcuaaacuuuuuauaaaaguuuaguuguaaacuuaac

ccuuuuauacaaaauaaaucaaguguguuuauugaauguugauugcuug

cuuuauuucagacaaccagugcuuugauuuuuuuuuaugcuauguuau

aacugaacccaaauaaauaccaguucaaauuuauguagacuguauuaaga

uuauaauaaaaugugucugacaucaa

Id4
4 (12)
cgaugaaggcggugagcccggugcgccccucgggccgcaaggcgccguc
236

AJ001972

gggcugcggcggcggggagcuggcgcuacgcugccuggcggagcacggc

cacagccuggguggcucggcagccgccgccgccgcugcggcggccgcgcg

cugcaaggcggccgaggcggcggccgaugagccggcgcugugccugcag

ugcgauaugaacgacugcuacagucgccugcggaggcucgugccuacca

ucccgcccaacaagaaagucagcaaaguggagauccugcagcacguuauc

gacuacauccuggaccugcagcuggcgcuggagacucacccugcuuugc

ugagacagccgccaccgcccgcgccaccucuccacccggccggggcuugu

ccggucgcgccgccgcggaccccacucaccgcgcucaacacugacccggu

gagaagccuuggcgggcacccugggcaucgcgggaaagguggcggggcg

gcgagauacggguggucuugcuccucucagggaaugacagccgcuucuc

ccgucuccaccgagagccgccugcugggcuuggugauccacuggucccu

gagccgagggcgguugggcuuggagcccugcgucuccggagugucccuu

gcaucacaggaggcuuccccagcuucgggcucggguggggacucugcuc

accugccuaguuuuccaggacgucuccugggugguggcgacacugugau

augcgcacucuaaccgcuuuuccccuugguguuggguugcuguuccagg

ccggcgccgugaacaagcagggugacagcauucucugccgcu

Peg3/
12
Sequence below.
237

Paternally

expressed

gene 3 zinc

finger

protein

AF038939

acuagucucgaccauguaccaucacggagacgacaccaacagugacaugaacagugacgacgacaugagccgaagugggagag

aaaccccacccccucgaccaucucaugcuuuuggcagugagcgagaccuggagcgcaggggcagaagcagagauguggagcc

ucgagaccgcuggccauacaccaggaaucccagaagcaggcugccucaacgggaucuuucucuuccugugaugucaagacca

cauuuuggacuggacagagaugaugacagacguuccauggauuaugagucucgaucccaggaugccgagucauaccagaaug

uuguggaacucaaagaggacaagaagccucagaauccaauucaggacaaccuggagaacuacagaaagcugcucucgcuggg

aguccagcuugccgaagaugaccgacacucucacaugacacaaggccacucaucgagguccaagagagcugccuacccaagca

ccagccgaggucucaaacccaugccugaggccaaaaagccaucccacaggcgugggaucugugaggacgagucuucucaugg

agugauaauggaaaaauucaucaaggauguggcucgcaaccccaaauccggaagagcaagggagcugaacgagcguccuccu

ccaagguuccccaggccuaaugauaacuggaaggacaguuccuccagcagaagagagucagugauccaggagagggguuaug

aagggagcgcauuuaggggcggcuuccgguucaacgcagaccuggcuuccagaagcagagcucuagaaaggaagaggcguua

ccacuuugauucugaugagcgggguucgggccaugagcauaaaagcugugugaggaagaagccuuuugaguguggugcuga

gaugagacaggcuaugagcaugggcaaccugaacagcccuuccuucucugagucgcagucaaucgauuuuggggccaaccca

uacgugugugaugagugcgggaggcaguucagugucaucucugaguuuguugagcaccagaucaugcacacuagggagaac

cucuaugaauauggagaguccuuuauucauagcguggcugucaaugaggugcaaagaagucaggguggggggaaacgcuuu

gaguguaaggaauguggagaaaccuucaguaggagugcugcccuggcagagcaccgccaaauccaugcuagagaauaucuug

cagaauguagagaucaggaggaugaggagaccaucaugccuagcccgaccuuuagugagcugcagaagauguauggcaaaga

uaaguucuaugagugcaaggugugcaaggagaccuuucugcacaguuccgcccugauugagcaccagaaaauccaugguaga

ggcaacucagaugacagagauaaugagcgugaacgcgaacgugaucgucuacgugcacgugcacgagagcagcgugagcgcg

aacgugaacgggagcgugagcgugagcuuggggaacccuuucugaccuguccaaacuucaaugaguuucggaagauguaca

ggaaagacaaaaucuaugagugcaaaguguguggggagagcuuucuucaucucucaucccugagggagcaucagaaaaucca

uacuagaggaaacccauuugaaaauaagagcaggaugugcgaggagaccuuugucccuagucagucucuccgacggcgccag

aaaacuuacagagagaagcuguucgacuuuaacaaugccagggaugcacugaugggaaacucagacuccagcgagcaucaga

aaaaccguucccgaaggaacuucuuugagggcagaggauuugagaaacccuucguugaaucucagaagagucauacuauaac

aagaccaccugaaaacaaagacgaugacaagccguucacaaucagugucaacccuaaugacaagcugaaacuccccaucaugg

aaaauggcucccagggcaaauccugugagaggucuguuauucauagcuugggcuccgcagaagcucagaagagucauggug

gacugggguucaguaaaccaagaccaguggcagagucuagcacccagagcucaagcagcauuuacuaccccagagcacacucu

ggaggcaacaccuaugaaggaaaagaauacaaggacucuaucauccauagcuugccagcuccucgaccucugaaacgucauag

agcaaaugaccauauucaaugugaugaggggggagaauccuccauuuauaucccagauauuauuaauaagggaaggaagauu

ccugccagagaagaugcuuaugaaggaaguagcagcagcaacuaccacacaccaaauguaucccgugcugagccuccaagucu

uucuggagagucccaugacucuaagcaggaugucacguuuucaguucccagcucaaguguucgugaacaccagaaagcucgu

gccaaaaagaaguacauugagcccaggaacaacgagaccucuguuauccacucccuaccuuuuggugaguugcuugcagguc

accguagggcaaaguucuuugagugucaggaaugcggggaggccuuugcucguaggucugagcucauugagcaccagaaga

uucaugauagagaaagaccuucuggaagccgacauuaugagcgcucugucauccgcagccuugcgcccagugacccucagac

caguuaugcccaagaacguuucauccaagaacaagugcguaaauucagagcguuuggacaacgcucaacuaccagcaacaacc

ucaguguacagaaaaucuaugcccaagagacauuuaaugccgaggagccccaugauaaagaaacucauggucaaaaaauucau

gacaaagagccauaugguaaggagcccaguggcaaggagccccauggugaugagccccaggacaaagaaccccuuguucagg

agaugcgcagugaagagccccaugaugauaagccccauggccaggagccccaugaugauaagccccauggccaggagccccau

gaugauaagccccauggccaggagccccacggugaugagccccauggccaggagccccacggugaugagccccaugacaagga

acccauugaucaggagaugcgcagugaagagccccacagugaagagucucauggugaugagccccauggugaagagucccau

ggccaggagaaaguugaagaugcuaccauucaggccucaguuucugaagagcaucagaaagaugacgcuggugaugcaaucu

augaaugccaggacugugggcugggcuuuacugaucucaaugaccucacaagccaccaggacacccauagcagaaaggcucu

gguugacagucgugaauaugcacauucugaaguucaugcccacuccgucagcgaauuugagaaaaaaugcucuggagagaaa

cuauaugaauguccaaaauguggggagucuuucauucacagcucguuacuuuucgagcaccagagaguucacgaacaagacc

agcuguauuccguaaaggccuguuaugacgcuuucaucgcucuguugcccguuagaccaaggagaaauugcacuguugaaa

ggaauccugccguuucugggucagccauucgaugccgucaguguggacaaggcuucauucacaguucugcccuaaaugagc

acaugagacagcacagagauaaugaaauaauggaacagagugagcuuucagaugagauuuucauucaaggccuagcccucac

ugaguaucaggggagugaaacagaagagaagcuuuucgagugcacaaucuguggggaaugcuucuucacugccaaacagcuc

ggggaccaccacaccaaaguucacaaggaugagcccuaugaguaugggcccuccuacacccaugccuccuuucucaccgagcc

ccucaggaagcacaucccacuguacgaaugcaaagauugcggccaguccuuccuagacgacacugucaucgcugagcgcaug

guguuucauccugagcgagaaggugggucagaaauaguagcugccacugcccaagaggucgaagccaauguccucaucccac

aagaaguacugcgaauccaggggucaaaugcagaagcugcugagcccgaaguggaggcugcagagcccgagguggaggcugc

agagccugagguggaggcugcagagccuauuggagaggcugaagggccagauggagaagcugcugagccugauggcgaggc

ugagcagcccaauggagaggcugaacagccaaacggugaugcugacgagccagacggagccgggaucgaagacccagaagaga

gagcugacgagccugaggaagacgucgaagagccagagggagaugcagaugagcccgauggugcagacauugaagacccaga

agaggaaggagaagaucaagagauugagguugaagaaccauacuacaacugucaugaaugcgcagaaacguucgcuuccagc

ucagccuuuggcgagcaucugaaaagucacgccagugugaucaucuucgagccggccaaugcuccuggagagugcucuggc

uacauugaacgggccagcaccagugcagguggugcggagcaggcagacgacaaguacuucaaaugugaugugugcgggcaac

ucuucaacgaccgccucucccuugccagacaccagaauucucacacugguugaguaaccaggcugaagaaaagaagagcaaag

ccaaaccuucuucccagaaccagacccuuaauaaaucacaaagagagccuaaaccaacccauaaugucuauaagaaauucaccu

uccuguauacauaccggacuucacaucaaagacuuucacucucaucacagacugaaaaaagaaaagacauugaacgcagggac

ucuuucaguuuuagcuguucccuauggaacaucaguguauauuugggaaagcuagagugaacaucuacaucuuccauuuca

ucuaaguaacuagauugagggaaaccuagugacaauuccagaccacagagguugccccagucgacuguaaaugauaccccuu

ucauacccuauacauaaugauuccugccauguauauaaaugagcaaaucagugauacauauauuuggauuuagugugcuau

agaauuuacaguuuacucuacagagcuaccuagccugguacucugauuuuuucccugaggaggaagagagcaacaauuuagc

auauauuuguaaguauuguccaugcagaagcuuuucugugcaucauuugaaccccauuaguauccuuuccaguaauggagu

guucuguccccuaccucuuagauaguccugugaaggugugggugugaaagaucgugugucuuugaauccuggcugugugg

aaacaggcauuuuagcuucuacagccauuuggugugcacccagaccccuugagacugauuguguaacccuuuacaauauaug

gauuugucucugugacccaaaucaacccaucccuacauuuauauaccuuacagugguuuucuugc

Growth Factors, Receptors and Related genes

Fz2/
9 (17)
uuuuuuuuuuuuuuuuuaccguucuuuauuuaaaaaaauaaaauagga
238

Frizzled 2

guccguagggugcacccuccccccuccugagugaaggagggcacggugc

AW123618

aguccggaccugggagaggggaaagcccggcaggcaggcgagaccgcuuc

acacaguggucucgccaugccggcuguuggugagacgaguguagaacuu

ccuccacgagugcagugucuugccggaccagauccagaagcccgacguga

ugcccacgaugagcgucaugagguauuugaucauguagacugugaaguc

gggcgacaugcggggcguguagugggccgggcaggggauggcuaggcuc

uugcagugcuggcuuacccaggagcgcucccagugcucgcggaaggccu

gcucauagaaguagcaggcgaug

Dkk3/
6 (22)
Sequence below.
239

Dickkopf 3

AJ243964

ggccgcgucgacgccucuccagcugcucuguggcagcccagcuaccggucgugaccagauccagcuugcagcucagcuuugu

ucauucgaauugggcggcggccagcgcggaacaaacaugcagcggcucggggguauuuugcuguguacacugcuggcggcg

gcgguccccacugcuccugcuccuuccccgacggucacuuggacuccggcggagccgggcccagcucucaacuacccucagg

aggaagcuacgcucaaugagauguuucgagagguggaggagcugauggaagacacucagcacaaacugcgcagugccgugga

ggagauggaggcggaagaagcagcugcuaaaacguccucugaggugaaccuggcaagcuuaccucccaacuaucacaaugag

accagcacggagaccagggugggaaauaacacaguccaugugcaccaggaaguucacaagauaaccaacaaccagaguggaca

gguggucuuuucugagacagucauuacaucuguaggggaugaagaaggcaagaggagccaugaauguaucauugaugaaga

cugugggcccaccagguacugccaguucuccagcuucaaguacaccugccagccaugccgggaccagcagaugcuaugcacc

cgagacagugagugcuguggagaccagcugugugccuggggucacugcacccaaaaggccaccaaagguggcaaugggacca

ucugugacaaccagagggauugccagccuggccuguguugugccuuccaaagaggccugcuguuccccgugugcacaccccu

gcccguggagggagagcucugccaugaccccaccagccagcugcuggaucucaucaccugggaacuggagccugaaggagcu

uuggaccgaugccccugcgccaguggccuccuaugccagccacacagccacagucugguguacaugugcaagccagccuucg

ugggcagccaugaccacagugaggagagccagcugcccagggaggccccggaugaguacgaagauguuggcuucauagggga

agugcgccaggagcuggaagaccuggagcggagccuagcccaggagauggcauuugaggggccugccccuguggagucacu

aggcggagaggaggagauuuaggcccagacccagcugagucacugguagaugugcaauagaaauggcuaauuuauuuuccc

aggaguguccccaaguguggaauggccgcagcuccuucccaguagcuuuuccucuggcuugacaagguacagugcaguaca

uuucuuccagccgcccugcuucucuggcuugggaaagacaggcauggcggguaagggcagcggugagucgucccucgcugu

ugcuagaaacgcugucuuguucuucauggauggaagauuuguuugaagggagaggaugggaaggggugaagucugcucau

gauggauuugggggauacagggaggaggaugccugccuugcagacguggacuuggcaaaauguaaccuuugcuuuugucu

ugcgccgcucccaugggcugaggcaguggcuacacaagagcuaugcugcucuguggccucccacauauucaucccuguguu

ucagcuccuaccucacugucagcacagcccuucauagccacgcccccucuugcucaccacagccuaggaggggaccagagggg

acuucucucagagccccaugcucucucucucaaccccauaccagccucugugccagcgacagcccuuccaaauggagggagu

gaaauccuuugguuuuauuauuuucuccuucaaggcacgccugccacuaaggucaggcugacuugcaugucccucuaacgu

ucguagcagugugguggacacugucuuccaccgacugcuucaauaccucugaaagccagugcucggagugcaguucgugua

aauuaauuugcaggaaguauacuuggcuaauuguagggcuaggauugugaaugaaauuugcaaagucgcuuagcaacaaug

gaaagccuuucucagucacaccgagaagucacaaccaagccagguuguguagaguacagcugugacauacagacagaagaag

gcugggcuggaugucaggccucagaugacgguuucaggugccaggaacuauuaccauucuguaucuauccagaguuauuaa

aauugaaaguugcacacauuuguauaagcaugccuuucuccugaguuuuaaauuauauguauacacaaacauguggcccuca

aagaucaugcacaaaccacuacucuuugcuaauucuuggacuuuucucuuugauuuucaauaaauacaaauccccuucaugc

aaaaaaaaaaaaaaa

Sfrp1/
6
Sequence below.
240

Secreted

frizzled-

related

protein 1

U88566

gcacgagcagcccgcagcccgccgcgccugugcgagccgggacagcacucggccccgcgcgcuccccgccccgcgccagcccc

gccgcggcgaccugcugcagcggaggaccccaucgaucggagacccggggagcagcgcgcagcccgcgagccgacgggcccc

gacugcgucuuuguccccggaggcuccgggaaguuugcagcgggacgcgcgcgugaaggcagcgugggcagccccgacguc

gccgagcaacaugggcgucgggcgcagcgcgcggggucgcggcggggccgccucgggagugcugcuggcguuggccgccgc

ucugcuggccgcggguucggccagcgaguacgacuacgugagcuuccaguccgacaucggcucguaucagagcgggcgcuu

cuacaccaagcccccgcagugcguggacaucccgguggaccugaggcugugccacaacgugggcuacaagaagauggugcug

cccaaccugcuggagcacgagaccauggcagaggugaagcagcaggccagcagcugggugccgcugcucaacaagaacugcca

caugggcacccaggucuuccucuguucgcucuucgcgcccgucugucuggaccggcccaucuacccgugucgcuggcucug

cgaggccgugcgcgacucgugcgagccggucaugcaguucuucggcuucuacuggcccgagaugcucaaaugugacaaguu

ccccgagggcgacgucugcaucgccaugaccccgcccaauaccacggaagccucuaagccccaagguacaaccguguguccuc

caugcgacaacgaguugaagucagaggccaucauugaacaucucugugcaagcgaguuugcacugaggaugaaaaucaaaga

agugaagaaggaaaacggugacaagaagauuguccccaagaagaagaaacccuugaagcuggggcccaucaagaagaaggagc

ugaaggcgcuugugcuguuccugaagaacggugccgacugucccugccaccagcuggacaaccucagccacaacuuucucau

caugggccgcaaggugaagagccaguaccugcugacagccauucacaagugggacaagaaaaacaaggaguucaaaaacuuca

ugaagagaaugaaaaaccacgagugucccaccuuccagucuguuuuuaagugauacuggggcggacuggggaaggggagug

uggcuuggggugagggugggggcgcguggaugacccuggcucuunggggcucacauauugcucucacccauacaguugug

gcuuuugcauugcaccuggcucuguuccuacagcgaacccucucccuunccuccauagccacauccagcuaaggccacggcc

uuuagauuaggaaggcuuuuuuuuuuuuaagggcugcagcagggccagcagcgacgugcaaaaggagaggcagaauccuuu

cacugagccuggggcacaaaaaacagaaaauguunnccgguuuggaaaaacaaaacaaaacggauuguaaagaacugcagacg

gacagcugcucagcucaacguuguucgggacaucauuaccaauugcuuguggagucuaagccucuacagguagaagagucu

gaucauugccaagccaggcugcuuucaguuuauuauuaaucccccucuuucugccuuagauagaccaucgccaccuucaaaa

cacacacacacacacacacacacacacacacacacacacacacacacacacacacuucugaaaguagccaggguaucccaguaua

gaacgggauagcuaaggguuugggugggaggccacugcuacucuaccuucagcuuuugaacuggccaccuuugauaggaaa

cugaggucucagauggacacuucuaccaguccaucgggauacaaggaugccaggcaagggucugcuuuugucugaaggagg

uacgugggcaugaagagacaugaggcauuucaggcugagaagcaacagcuacuaguuuucaacaauagaguggaagaaauga

gcaaagguagaaaugucaagcaggucacaagucagggugauugggggaauccugugccaacagccucacuuuguaauuccau

cugucacuuucaaaagaacagcagcauaagacagggauaaaagcccacauacccuccaaggcuugaguaaaaguccacacuca

gcauuucaaagacuaacgucguugacugcccaaggcugcccucuuaauacaccgccuaugcaugugcuguggaaggcaacuc

ugugcaugugcuguggaggagaugggccucauggcugugcuggcugcccggaaucaguauagcguggaaggagacaguauc

cauagacucugcuuuucugcaaggaaagcccuuuuccuuauacaugauugccuauaauucagacaaauuuaaaaucgcugcc

ugccugagcccuccaccuuuacuuuugcauucuccggucauauucuuuugaggcuaaagugcccuauccgaggagaugguu

ucaaaggcuaacuaaucugcagcuuucccaagugcccagagguauuucucaaaguugguaugcuuaauaagugauguaaaua

uuccaguucucuuaggcagccuuacuccuguugucccug

Dab2/
15
Sequence below.
241

Disabled

homolog 2

U18869

aauuccgaguggccgcgcggcuauuuaaguggcguuacuccgcguccucggcgcugcagccuugaggcuucgggcgcgggg

gaagucaugcuggcuccacagaagcacuagcuaguccguguacuuuguggguucuguccuuuugagaccugcccgccgggg

auuggcugguaucagugacugucuacugcuggauuuucugcuugccuucccgucaugucuaacgaaguagaaacaagcaca

accaauggccagccugaccaacaggcugccccgaaagcgccaucaaagaaggagaagaagaaagguucugaaaagacagacga

guacuuguuggccagguucaaaggugaugguguuaaauacaaggccaagcuaaucgguauugaugaugugccugaugcucg

aggagacaaaaugagucaggauucuaugaugaaacucaagggaauggcagcagcuggucgcucucagggacaacacaagcaa

agaaucugggucaacauuuccuugucuggcauaaaaaucauugaugagaaaacugggguaauugaacaugaacauccaguaa

auaagauuuccuucauugcucgugaugugacagacaacagagcauuugguuauguguguggaggugaaggccagcaucaau

uuuuugcuauaaaaacagggcaacaggcugagccauuagucgucgaucuuaaagaccuuuuucaaguuaucuauaauguaa

agaaaaaggaagaagauaagaaaaagguugaagaagccaacaaagcagaagagaauggaagugaggcccuaaugacccuugau

gaucaagcuaacaaauugaagcuggguguugaccagauggauuuguuuggggacaugucuacaccuccugaccuaaauagu

ccaacagaaagcaaagauauccuguuaguggaucuaaacucugaaaucgacaccaaucagaacucuuuaagagaaaauccauu

cuuaacaaauggagucaccuccuguucucucccucgaccaaagccucaggcauccuucuugccugagaacgccuuuucugcc

aaucucaacuucuuucccaccccuaacccugauccuuuccgugaugaucccuuugcacagccagaccaaucggcacccucuuc

guucgauucucucacaucuccagaucagaagaaagcgagucugaguagcucgucuacuccacagaguaaagggccccugaac

gucgauacugauuacuuuggucagcaauuugaccagcucucuaaccggacuggcaaaccggaagcucagggaggcccguggc

ccuacccaaguucgcagacccagcaagcagugagaacucaaaaugggguaucugaaagagaacagaacggcuuccauaucaaa

ucuuccccgaacccuuuugugggaagcccucccaaaggacuaucgguaccgaauggcguaaagcaggacuuggaaaguucug

uccaguccucagcacaugacuccauagccauuaucccaccuccacaaaguaccaaaccaggaagaggcagaaggacugcuaag

ucuucagcaaacgacuugccugcuucagacaucuuugccucagaaccuccaggccagaugucccccacaggacaaccugcagu

cccgcagucgaacuuccuggaucucuucaaaggcaaugcuccucccccaguggggccccuuguaggucuagguacgguccca

guaacacccccccaagcaggacccuggacgccuguugucuacaguccuucgacaacuguggucccaggagccauaauaagug

gccagccucccaguuuucgccagccacucguuuuugguacaaccccagcaguacaagucuggaaucagucuccaucauuugc

aaccccagcuuccccuccaccccccacaguuugguguccuaccacaucuguggcgcccaacgcuuggucauccacaagcccuc

uggggaauccuuuucagaguaauaauaucuuuccaccucccaccauguccacucaguccucuccucagccuaugauguccuc

uguucuggccacaccgccucaaccaccuccccgaaauggcccacuaaaggacauucccagugacgcuuucacuggcuuagacc

cccuuggggauaaagaggucaaggaagugaaagaaauguuuaaggacuuccagcugcggcagccaccucuuguucccucaag

gaagggggagacgccucccucugggacuucaagcgccuucuccaguuacuucaacaauaaaguuggcauuccucaggagcau

guagaccaugaugauuuugaugccaaucaacuguugaacaagauuaaugaaccaccaaagccagccccgagacaaggugucc

ucuuggguaccaagucugcugacaauucacucgagaacccuuucuccaaaggguucagcucaucaaaccccucugugguuuc

ucagccugcaucuucugauccccacaggagcccuuucggaaauccuuuugccuagcuucugaaguuguaaugaugacuaucc

agaugagcaaaagacuggcuuuggucaagaaugaagcagacagccagaaacauguugaccucuguccucgcuccagcuuuga

cguauuaucuguuacccuauuuguuuuggccucuuguacuuguaaaaugccuuucauuuuccugucuaggcuaaagcuaaa

cuuaaacuauggcuuuacguaaauuaagcuccuaaacucucuagcuccaauauaaaugaaguagcuucccuaucaaaucccu

gucuguugugcccccuugaaacuuccagaauauucuccauucuacccuccauuugggaggagcggcuaccuuuacccuuaa

uaucacacugccuugagucaauguccaaauacucauagcucucaaagucauuugggguuccuggugugcggccuaaaccuaa

agcauccuauuaauagggaaguaagacaccuugcuuccuauguccacucagggagaauuuuauuuaauaaaaugaaagcaag

acuaacuucucaaauccacccaaggaccauuuugagauggucguuucucagcuaacugcaccauuuaccaauccugccccaag

uggugcuuacauuugacuugaagaagagaaagagcuaacucaaaacacaaggcauuauucaaagcuaauaaaacaauuucuc

ccuggggccccacauuguuuucauuccagauacguugcagcuguuugacccugaugacauuaugcccuacauuuuccuuga

agauccugauuuuauuucaugugauuuuuguuucucaauaaagaugauuauugugugcacggaauuc

Cktsf1b1/
12 (12)
Augaaucgcaccgcauacacugugggagcguugcuucuccuccugggga
242

Gremlin,

cccuacugccaacagcugaggggaaaaagaaagguucccaaggagccauu

Cysteine

ccgccuccugacaaggcucagcacaaugacucugagcagacccagucccc

knot

accacaaccuggcuccaggacccgggggcggggccaggggcggggcaccg

superfamily

ccaugccuggagaggaggugcuugaguccagccaagaggcccugcacgu

1, BMP

gacagagcgcaaguaucugaagcgagauuggugcaaaacucagccccuga

antagonist 1

agcagaccauccacgaggagggcugcaacagccgcacuaucaucaaccgc

AF045801

uucuguuauggccagugcaacuccuucuacauccccaggcacauccgaaa

ggaggaaggguccuuucagucuugcuccuucugcaagcccaagaaguuc

accaccaugauggucacacucaacuguccugagcuacagccacccaccaa

gaagaaaagggucacacgcgugaagcagugccguugcauauccaucgacu

uggauuaa

Fgfr1/
10
Sequence below.
243

Fibroblast

growth

factor

receptor 1

U22324

guggaauauccauggagguacggagccuuguuaccaaccuuuaaccgcagaacugggauguggggcuggaagugccuccuc

uucugggcugugcuggucacagccacucucugcacugccaggccagccccaaccuugcccgaacaagcucagcccuggggag

ucccuguggaaguggagucucuccugguccacccuggcgaccugcuacagcuucgcugucggcuucgcgaugaugugcaga

gcaucaacuggcugcgggauggggugcagcugguggagagcaaccguacccgcaucacaggggaggagguggaggugcggg

acuccauccccgcugacucuggccucuacgcuugcgugaccagcagccccucuggcagcgauaccaccuacuucuccgucaa

ugucucagaugcacucccauccucggaagaugaugacgacgacgaugacuccuccucggaggagaaagagacggacaacacca

aaccaaaccguaggccuguagcucccuacuggacauccccagagaaaauggagaagaaacugcaugcggugcccgcugccaag

acggugaaguucaagugcccgucgagugggacacccaaccccacucugcgcugguugaaaaauggcaaagaguuuaagccug

accaccgaauuggaggcuacaagguucgcuaugccaccuggagcaucauaauggauucuguggugccuucugacaagggcaa

cuacaccugcaucguggagaaugaguaugggagcaucaaccacaccuaccagcuugacgucguggaacgaucuccgcaccga

cccauccuucaggcagggcugccugccaacgagacaguggcccugggcagcaauguggaguucauguguaagguguacagcg

auccgcagccucacauucaguggcugaagcacaucgaggugaacgggaguaagaucgggccagacaacuugccguaugucca

gauccugaagacugcuggaguuaauaccaccgacaaggaaauggaggugcuucaucuacggaaugucuccuuugaggaugc

gggggaguauacgugcuuggcggguaacucuaucggacucucccaucacucugcaugguugaccguucuggaagcccugga

agagagaccagcugugaugaccucaccgcucuaccuggagaucauuaucuacugcaccggggccuuccugaucuccugcaug

uugggcucugucaucaucuauaagaugaagagcggcaccaagaagagcgacuuccauagccagauggcugugcacaagcugg

ccaagagcaucccucugcgcagacagguaacagugucagcugacuccagugcauccaugaacucugggguucuccugguucg

gcccucacggcucuccuccagcgggacccccaugccggcuggagucuccgaauaugagcucccugaggauccccgcugggag

cugccacgagacagacuggucuuaggcaaaccacuuggcgagggcugcuucgggcaggugguguuggcugaggccaucggg

cuggauaaggacaaacccaaccgugugaccaaaguggccgugaagauguugaaguccgacgcaacggagaaggaccugucgg

aucugaucucggagauggagaugaugaaaaugauugggaagcacaagaauaucaucaaccuucugggagcgugcacacagga

ugguccucuuuaugucauuguggaguacgccuccaaaggcaaccuccgggaguaucuacaggcccggaggccuccugggcu

ggaguacugcuauaaccccagccacaaccccgaggaacagcugucuuccaaagaucugguauccugugccuaucagguggcu

cggggcauggaguaucuugccucuaagaaguguauacaccgagaccuggcugcuaggaacguccuggugaccgaggauaac

guaaugaagaucgcagacuuuggcuuagcucgagacauucaucauaucgacuacuacaagaaaaccaccaacggccggcugcc

ugugaaguggauggccccugaggcguuguuugaccggaucuacacacaccagagcgauguguggucuuuuggagugcucuu

gugggagaucuucacucuggguggcuccccauaccccggugugccuguggaggaacuuuucaagcugcugaaggaggguca

ucgaauggacaagcccaguaacuguaccaaugagcuguacaugaugaugcgggacugcuggcaugcagugcccucucagaga

ccuacguucaagcaguugguggaagaccuggaccgcauuguggccuugaccuccagccaggaguaucuggaccuguccauac

cgcuggaccaguacucacccagcuuucccgacacacggagcuccaccugcuccucaggggaggacucugucuucucucauga

gccguuaccugaggagcccugucugccucgacaccccacccagcuugccaacaguggacucaaacggcgcuga

Fgf1/
10
auggcugaaggggagaucacaaccuucgcagcccugaccgagagguucaa
244

Fibroblast

ccugccucuaggaaacuacaaaaagcccaaacugcucuacugcagcaacg

growth

ggggccacuucuugaggauccuuccugauggcaccguggaugggacaag

factor 1

ggacaggagcgaccagcacauucagcugcagcucagugcggaaagugcgg

M30641

gcgaaguguauauaaaggguacggagaccggccaguacuuggccaugga

caccgaagggcuuuuauacggcucgcagacaccaaaugaggaaugucugu

uccuggaaaggcuggaagaaaaccauuauaacacuuacaccuccaagaag

caugcggagaagaacugguuugugggccucaagaagaacgggagcugua

agcgcgguccucggacucacuauggccagaaagccaucuuguuucugcc

ccucccggugucuucugacuag

Gpr49/
64 (377)
Sequence below.
245

G protein-

coupled

receptor 49

FEX

AF110818

auggacaccuccugcguccacaugcuccuguccuugcuggcgcugcugcaguugguggccgccggcagcucaccgggaccag

augcgauaccgcggggcugcccaucacacugucacugugagcuggauggcaggaugcugcucaggguggacugcucggacc

uggggcucucggagcugcccuccaaccucagcgucuucaccuccuaccuggaccucaguaugaacaacaucagucagcuacc

cgccagucuccuacaucgccucugcuuccuagaagaguuacgucuugcuggaaaugcuuugacacacauucccaagggagcg

uucacgggccuucacagccucaaagugcuuaugcugcagaacaaccagcugagaaagguuccggaggaagcgcuacagaauu

ugagaagccuucaaucccugcgccuagaugccaaccacaucagcuacgugccacccagcuguuucagcggccugcacucccug

aggcaccuguggcuagaugacaaugcucucacagacgucccuguccaggcuuucagaaguuuaucagcccugcaagccauga

ccuuggcccugaacaaaauacaccacauagcagacuacgccuuuggaaaccucuccagccucgugguucugcaucuccauaau

aauagaauccacucccugggaaagaaaugcuuugauggacuccacagccuggagacuuuagauuuaaauuauaauaaccuug

augaauuccccacugcaaucaagacacucuccaaccuuaaggaacuaggauuccacagcaacaacaucaggucaauaccggag

cgagcguucguaggcaacccuucucuuaucacaauacacuucuaugacaaccccauccaauuuguuggaguaucugcuuuuc

agcauuugccugaacuaagaacacugacuuugaauggugccucgcacauuacugaauuuccucacuugacaggaacugccac

ccuggagagucugacuuuaacuggagcaaagaucucaucucuuccccaggccgucugugaucaguuaccuaaucuccaagug

cuagauuugucuuacaaccuacucgaagacuuacccaguuugucaggcugccaaaaacuucagaaaauugaccugaggcaua

acgagaucuaugaaauuaagggcagcacuuuucagcaguuguuuaaccuccgaucucugaacuuagcauggaauaaaauugc

uaucauucaccccaaugcguuuucuacguugccgucucuaauaaaguuggaccuaucauccaaucuccugucguccuucccu

gugacuggguuacaugguuuaacucacuuaaaauuaacagggaaccgagccuuacagagccugauaccaucugcaaacuucc

cagagcucaagauuauagaaaugccaucugcuuaccaguguugugcauuuggggggugugagaaugucuauaaaauuucua

accaauggaauaaagacgacggcaacaguguggacgaccuucauaagaaagacgcuggguuauuucaaguucaagaugagcg

ggaccuugaagauuuccuacuugacuuugaggaagaccugaaugcccuucacucggugcagugcucgccuuccccagguccc

uucaagcccugugagcaccuauuugguagcuggcugauccgaaucgggguguggaccacggcaguacugacgcuuuccugc

aaugccuugguggcuuugaccguguucagaacuccccuguacaucucuuccauaaagcugcuaauugggguaaucgcggua

guggacauucucaugggggucuccagugcugugcuggcugccguggaugcauucacuuuuggccguuuugcucagcacgg

ugcguggugggaagacggaaucggcugccaaaucguuggcuuccuguccauuuuugcuuccgaaucgucgaucuuccugcu

cacucuggcagcgcuggaacgagguuuuucugucaagugcucuucgaaguuugaagugaaagcuccccuuuuuagccugag

agcgaucguuuugcuauguguccuguuggcccugaccauugccacaauccccuugcuaggaggcaguaaguacaaugccuc

uccccucugccugcccuugcccuuuggggagcccagcaccacgggcuacaugguggcucucguguugcucaacucucucug

uuuccucauaaugaccauugccuacacaaagcucuacugcaguuuggagaaaggagagcuggagaaucuuugggauuguuc

gauggugaagcacauugcucuguugcucuucgccaacugcauccuuuacugccccguggcuuucuuauccuucuccucuuu

gcuaaaccucaccuuuaucaguccugacgucauuaaauuuauacuucucgugaucgucccacuuccuuccugucucaaccca

cuucucuacauugucuucaauccccauuuuaaggaggauaugggcagccugggaaagcauacccguuucuggaugagauca

aaacacgcgagucugcuguccauuaacucggacgauguugagaaacgguccugugagucaacccaagccuuaguauccuuua

cccacgccagcauagccuaugacuugccuuccacuuccggggcaucaccagcuuaccccaugacugaaagcugucaucucuc

uucaguugcauuugucccaugucucuagugacuaugagagaggaacguuuuuaagaguuggaaaccugaaaagugauuucu

aucagagcaguagcuaagaaaagcugagcuaaaaaccuaccuuaaaacccaagcaaacaucucuaaauugguguggaaacagu

ggugccuuagagcaggagagcaucauuaaacaccgcuuguaucauuuguucagcuaagaaggaaagccaucaagucacuuag

gugaacccagaugagaaaagcagccugaaaugcucuucgcauuguagucucuucugacucaccagcauagucucccauagug

agaagacucguuggaugacucaauggguguauuuaaauccacaaauuccuuguuuaaaagguuagaguuuuaagaaaaaaaa

aaaaaaaaa

Igfbp5/
37
Sequence below.
246

insulin-like

growth

factor

binding

protein 5

L12447

uuuuuuuucuucaccuccucccuuuucaaggccuccaagcuaauuauuucuguugcuuuggagugagcaauucugugguu

cucuccaccaccacccccaauucugacccgaucccgccuggggguuucuacggucuccgcucacucugcgugcaccuggcgc

gccucuuuuuuucacccccaaccuguugcaagucuuuaauccucgcaauugggacuugcgugcaggcaccugaauccuccu

ugccucauauuuugcaaguguuugggggagagcaccugcucuaccugcaagagauuuaaaaggaaaaaaaucuccaggcucc

cucuuucuccacacacucucgcucuccugccccgccccgagguaaagccagacuccgagaaaauggugaucagcgugguccu

ccugcugcuggccgccuaugccguaccggcucaaggccuggguucuuucgugcauugugaacccugcgacgagaaagcucu

guccauguguccccccagcccucugggcugugagcuggucaaagagcccggcuguggcugcugcaugacuugcgcccuggc

ggagggacagucguguggugucuacacagagcgcugcgcccaggguuugcgcugccucccccggcaggaugaggagaagcc

gcugcacgcccugcugcacggccgcgggguuugccucaacgaaaagagcuacggcgagcaaaccaagauagagagagacucu

cgggaacacgaggaacccaccaccuccgagauggcugaagagaccuacucccccaaggucuuccggcccaagcacacucgcau

uuccgagcugaaggcugaggcugugaagaaggaccgcagaaagaagcugacccaguccaaguuuguggggggugcagagaac

acugcccaccccagagucaucccugcaccugagaugagacaggaauccgaacaaggccccugccgcagacacauggaagcuuc

ccuccaggaguucaaagccagcccacgcauggugccccgugcuguguaccugcccaacugugaccgcaaaggauucuacaag

agaaagcaguguaagcccucccguggccgcaaacguggcaucugcugguguguggacaaguacggaaugaagcugccgggca

uggaguacguggauggggacuuucagugccacgccuucgacagcaguaacguugagugacgcguccccucccuuccuccccc

uauccuacccccccagccccaacuccagccagcgccucccuccaccccaggacgucacucauuucaucucauuuaggggaaau

auauauacauauauauuugaggaaacugaggaccucggaaucucuagcaagggcuaaggagacacuccccaccaugaccccg

gaaauguauuccuuuuugaagcaaguugaacggacagagaagggaaggagagaagaagcaagagggagcgagagauggaaag

aaagcaaagcguuggaauagaggaaaagagggaaggacagauaggauuagagagagaagagagaaacagcaaggcagaaagga

cuccacaaccaaggcugaaucugcccuuuugcuuucagcucuagccuggggucagaaaaaguguggcauucagugacaccca

guuuagauuggucaaggggagaaaagaaacaaggugugucagugccucucgggucuguccccuccugcagccagcagugug

gauggcuagaccccucacccuccucuccucuuacccaagugcagggugauuucauccccaaauuuacaaagacuaaaaugcau

uccaucccucugaaaauaaacaaaagugagugauugaagauagguuuucccccagcagacaagugaacucagaaugugugca

aauuuuacucuuguuaaagauuuuuuuaagaagucaguacgcacccccaacacuggaaagacuugauucuccagggugacaa

gcaauucagaagcgcguggcuucggcccuugauuucacuagacucaaagcuggcccggcagccucuguggaggaggaugag

agguggagaaaaccaaggggcuuguacucacccacaagacuccauguagacuuuauaggcauauaaaucuauuuucuuuacc

uuuuuuucccuuucccuuucuuucgaaguuuugcauuaccucuuuaaaguaguuuuuuuuaggacacugaagaucuuccu

cauucugggaaaaauccauauuucacaaauacaacccagaacgccagcuuggccugcguccaggcagccuuucucgugagcu

acaaguguggcucuuuuguggggcaccgauuuggaucuucucaugauuccaaacguguguugaagugaauccaccaagcca

gguaacugccagcacccaagggugcaucaagugcauagcccaggucaccccauuucagccuuccaacccgcagaaaguaacug

ucucacaccacaccacauaaaccugccagauccaucuguaacccacuggccugcccagaccuuuuuuucccaucugcauuuuu

uuuuuugaacugcauuuugaaagccucccucagaugccaggcugacagaucagagagaaacuaacaugagagaugacagagg

aggaggaaguggagggugggggcagagacuuccacagagagacauagaagauggagcagaggucuggggguggggaggaca

agaaagagacagagagaggaaaauaccaauagaauuuuccuuggugucucccaucuaaucaacucucugagauuugagagga

aaaagaaggcaggggaagaacuugagguagaaaugaggucaguucaagucacagggcccagaugguggguaacugaggcagg

auccagacuugagacacacgguuggaaacaaggcugguuagccugacuggguauugaagggugaagaggaugccuuggaaa

gacagcacaacuucaguucaacuucaggcccccaaggaggaacugaggccaaagaauccuucaagugcuucaugagucuccuc

ugcccgacucaaacauccuucccugugauggaggaugguagaaagcccaggacaacucaggcccggaucuucacgacuguug

ucauuugccagccugauuuugauccaagagaagcaucucauugcccacuggcuucuucaacaaagaggugcuuaacaaaagg

cucaggacuaucuuugaagacugaagauaaccuuccaggagaggagacucggacauugguacaggaggccccuuuuggcgg

gggacacagcucuuugcgcucucuugauggcauggcauaguagaggcccccuccaacccggaacauggagcaacacaaaggg

agagcaaagaaacugacgugcgucgacucauaggacauggguggcugcgggcacagaaagggaugccuccuguugccuggac

aggacaguuggcugggaaggaaagagaaaauugaucuucauaagacaaagggccugaugggauggcaauagaaggacuuacc

agaccugcagggucaguauacccaucaccccgcacaacauccccagcccccaacucaaacuucaauauaucuuaggccaguau

ccuagaccuaagucucuccuuucugccauuauuucuccgcaucuugagcagucaucugacugagauuugccaaguggauac

ugggguaccacugccccccaagaaaagacugagccaggaacugccuacucgcucccccucccgagccuggagcuaacuccugu

gaggggugcucucuucaccccacaacuuacuagaccuugagugagccucugucccuuaugugggcucuucgcugugagcca

cagauggaggucauuguauagacaguuagccuuccccaggucagccuaccucccccaaacuugugagucuccccgcugcuca

uauggagaggcaugucuaagacagcaagucuucuagaggaagcuugccuuuaacagacagauggaacuaaaccuuccaaaug

ggagaucuggcugaacccaggauacagagaccauggacauggauggggucaucaagagaagagggauguccuucuccagguu

agggagagagaaggcaaguuugcaacgaucccaucaugcccugagcaagaagcuuuuggcccaggcuagccuuuaacuccau

uagaggccucucuguuggguuuauccacagcaguaggcccaaguauggccuguccccaccucuacuaucccguggaagguu

ucuucccaccccuuuuugacaaaugccucacucgagcaguggaaagauagcucucuucccccucuucugccagguaacaaag

agaccuaaccaggaccuauucuccaccccagccagucuugaccagccagaacaaagcagggaaccuggagaauaaaagacucu

acguuccucugacaaagacucuacguuucucugacggccaggccuaaacagacaaggcuugggaacaucugccccacaggau

acggaggaggucagcugugcucacuccucuucuccuuccaagacccucuuccgaccaugacuuaucuccaugguaacauccu

caccaucauucucccacuaccaaggguugccauggcaaccucccaaccaccugcccaucccaggcaggcagcuguccuucugc

ucagaacccuagaggacucuaggugaaauuuuacagcuuaagagaggagugagccaaggagaagagacccuguaguccucug

gcuuucaagagaaagaaggcuaugauuuaaaacacaguagaagggaaagaggucucgucgaggucgaccucucccggggagc

uuagggguuguacugucuuuauuuuuuaaaccacuaaagugcaaunuuuccugcacucuuguuaccccgccucucuucccu

guuagguuuucauuuccuugagcagacuuucuugguuuuuuaauggaguauagacuuucaccacuucacagacucuggccu

ccucuccaagucucucuggauggggaaaaggaagguagagggucagaggggaaggggucccucgucaccccgcauccauuca

cccccacuucucuggucccuagucaccggcuucaccccnaucuccgacaccaucacugucacacaguagccugucacacggau

aguacaguucagacaagacuccuucagauuccgagacgccuaccgguuguuuuugguuuuuguuuuguuuucuuuuguuu

guuuguuuguuuguuuuuuacaacagcaauaaccacaucacauauuacuguagcucucuauaguguuacguucagacaccg

uagcucuguccucucuuauuuuguugguuuugacuuaaaaaaaaauacuuaugcuuuuuacuggugaaacagauugaaaaa

aaaauugaacaacaaaccaguuugugaaaaaaaaaaaaaaugugaaaaaaaaucaccccgauguggaagagcucggcuccucu

uuagcauuuuguacuuaaggaaauaaaaaagaaaaaccuggaagaucucacauuuuauuacaaagugaaaaaaaaa

Myoc/
111
Sequence below.
247

trabecular

meshwork

induced

gluco-

corticoid

protein

AF041335

guccagucugcagucuguauucggaagacauagauacuaaauacauggcaacucuuuuuuuuguuuguuuuaauucaucag

gauguggagcgcuagucuggguaggagagccagucacccugaggacagcugaaacaaucgcuggcaaguauggagugugga

ugagagaccccaagcccacccaccccuacacccaggaaagcacauggaggauugacacgguuggcacagagauccgccaggug

uuugaguacagucagauaagccaguucgagcagggcuauccuuccaagguccaugugcucccucgggcacuggagagcacgg

gugcugugguguaugcggggagccucuauuuccagggggcugaguccagaacuguggucagguaugagcuagacacggaga

ccgugaaggcagagaaggaaauuccuggagcuggcuaccacggacacuucccguacgcgugggguggcuacacagacauuga

cuuagcuguggaugagagcggccucugggucaucuacagcacggaggaagccaagggggccauaguccucuccaaauugaac

ccagcgaaccuggaacuugagcguaccugggagacuaacauccguaagcagucuguggccaaugccuuuguuaucuguggca

ucuuguacacggugagcagcuacucuucagcccaugcaaccgucaacuucgccuacgacacuaaaacggggaccaguaagacc

cugaccaucccauucacgaaucgcuacaaguacagcaguaugauugacuacaacccccuggagaggaagcuguuugccuggg

acaacuucaacauggucaccuaugauaucaagcucuuggagaugugaggagccucuaugccuaccagcaaaggccagaaaag

gugaaguuccgggcucccgggugaagcagcugucagcagaggcagccagaugcauggaguuucuccuccugcuaaagauuu

uguuuauccgggucaauguacagcuagcuccccucugacugacacguccuccaggcuuguauagucgcauagacucuguuc

ucuucugucagcuuucaaagggcuguuccucuuuuaaaaaucacauagug

Itm2a/E25
30
Sequence below.
248

putative

Integral

membrane

protein 2A

L38971

gggagaccugagcucgcugcugccuguggaagacugggagaggagacacuaagugcugcucaagcaagcgcgauccucuccu

cuuucaaccugcagcccaagauacugauucgagccgcgccuuaccgcgcagcccgaagauucaccauggugaagaucgccuu

caacaccccuacggcggugcaaaaggaggaggcgcggcaagauauagaggcgcucgucagucgcacuguccgagcucaaauc

cugacuggcaaggagcucagaguugucccgcaggagaaagauggcucaucugggagaugcaugcuuacucuccuaggccuc

ucauucaucuuggcaggacugauuguugguggagccugcauuuacaaguacuucaugcccaagagcaccauuuaccauggu

gagaugugcuucuuugauucugaggauccugucaauuccauuccuggaggagagccauacuuucugccugugacugaggag

gcugauauccgugaggaugacaacauugccaucauugaugugccugugcccaguuucucugauagcgauccggcggcaauu

auucacgacuuugagaagggaaugacugcuuaccuggacuugcuuuugggaaacuguuaucugaugccccucaauacuucc

auuguuaugacuccaaagaaucugguggaacuuuuuggaaaacuggcaaguggcaaguauuugccucauacuuaugugguu

cgugaagaccugguugcuguggaagaaauucgugauguuaguaaccuugguauuuuuauuuaccaacuuugcaacaaccga

aaauccuuccgccuuagacgcagagaccuucugcuggguuucaacaagcgugccauugacaaaugcuggaagauuagacacu

uccccaaugaauuuaucguugaaaccaagaucugucaggagugaaaugugacagauaaagaguauccuugauaauaagaagu

caggaacuuaccgucugacuuggaaaauugaaauugaugggauacucaugcuauuuacucauacauuuacucuauugcuua

uacuggaaaaggaaagggaaaggggggagaaaacuacuaaccacugcaagcgauuguccaauucuacuuuaauugacauugc

uugcuguuuucaacaagucaaaugauuaucuuuucucuugaauuuauaggguuuagauuucugaaagcagcaugaaugug

ucaucuuaccauccugacaauaaagcccauccucugguuuuauuuaaagcaagcucuuuccaacaucacuuggcuagagcau

gcuuuaaauuuaaaauauuugaaauuuguuuuugacauuuuuuugugugaaacaugucaaaucucuuaccauucuuuggu

uuucuucuuuauuauguucaacucuccugauuucagaaguuacauuuuugcauuucuaucaggugcuguguaacgaaucu

gacugauaugugaacaaucuucaugaggaagcaauuuuuuacucauguaaugauucuuucucacugauaucuguauuguga

aauccacagaacuguacaggugcugaaugcuguaaggaguucugguuguaugaauucuacaacccuauaauaaaguuuaccg

uauucaauca

Eps8/
15
Sequence below.
249

epidermal

growth

factor

receptor

pathway

substrate 8

L21671

ggccauuaccaaucgcgacccgcgcacacacggcccgggcggcgggcgaagcgggcucccggggcgcugggcgcagggcgcg

gggcaagccccagcagcgugucugcaacggggcgcggcgggcgcuccagcuccgggaucuuucucccucggucaccucccuc

gcgucuagggaggucguggcacucccugaggagcgcggcugcucggagggcggauccuagaacagaggcgugagagccggc

augaauggucauaugucuaaccgcuccaguggguauggagucuacccuucucaacugaaugguuacggaucuucaccacccu

auucccagauggacagagaacacagcucaagaacaagugcaaaggcccuuuaugaacaaaggaagaacuaugcccgagacagu

gucagcagugugucggacgugucccaguaccgcguggaacacuugaccaccuucgugcuggaucggaaagaugcaaugauca

cugucgaggacggaauaagaaagcugaaguugcuggaugccaagggcaaaguguggacucaagauaugauucuccaagugg

augaccgagcugugagccugauugacuuagagucaaagaaugaauuggagaauuuuccucuaaacacaaucucgcauuguca

agcaguggugcaugcaugcagcuaugacuccauucucgccuugguaugcaaagagccaacgcagagcaagccagaccuucac

cuuuuccagugugaugagguuaaggcaaaccuaauuagugaagauaucgaaagugcaaucagugacaguaaaggugggaaac

agaagaggcggccggaggcccugaggaugauugccaaagcagauccuggcaucccuccuccucccagagcuccugccccugu

gccaccggggacugucacacagguggacguuaggagucgcguagcagccuggucugccugggcagcugaccagggugacuu

cgagaagccccggcaguaccacgagcaagaagagacgcccgagaugauggcagcccggaucgacagggaugugcaaaucuuaa

accauauuuuggaugacauugaauuuuuuaucaccaaacuccaaaaagccgccgaagcguuuucugagcuuucuaaaaggaa

gaaaaguaagaaaaguaaaaggaaaggaccuggagagggcguuuuaacacugagggcaaaaccgccaccuccugacgaguuu

guugacuguuuccagaaguuuaaacauggauucaaccuucuggccaaguugaagucccauauccagaacccgagugcuucag

aucugguucauuuuuuguuuacuccacuaaauauggugguccaggcaacagguggcccugaacuggccaguucgguacuca

gcccacuguugacaaaagacacaguugauuucuuaaacuacacagccacugcggaggaacggaagcuguggaugucacuggg

agauaguugggugaaagugagagcagaguggccgaaagaacaguucaucccaccuuacgucccgagguuccgcaacggcugg

gagcccccgaugcugaacuucaugggcgcgcccacagagcaagacauguaucaacuggccgaguccguggccaacgcagaaca

ccagcgcaaacaggacagcaagaggcuguccacagagcauuccaauguguccgacuauccuccagccgacggauaugcguaca

guagcagcauguaccacagaggaccacaugcagaccacggggaggcugccaugccuuucaagucaacuccuaaucaccaagua

gauaggaauuaugacgcagucaaaacacaacccaagaaauacgccaaauccaaguacgacuuuguggcgaggaacagcagcga

gcucucgguuaugaaagaugaugucuuagagauacucgacgaucgaaggcagugguggaaaguccggaaugccaguggaga

cucuggguuugugccaaauaacauucuggauaucaugagaacuccagaaucuggaguggggcgcgcugaccccccauacaca

cauaccauacagaaacaaaggacggaauacggccugagaucagcugacacuccuucugccccaucacccccuccaacgccagca

cccguuccggucccccuuccaccuucuguaccagcacccguuucugugcccaagguuccagcagaugucacccgccagaaca

gcagcuccagugacagugggggcagcauugugcgggacagccagagauacaaacaacucccaguggaccgaaggaaguccca

gauggaagagguucaggaugagcucuuccagaggcugaccaucgggcgcagugcugcgcagaggaaguuccacgugccacg

gcagaacguuccagugaucaauaucacuuaugacuccucaccggaagaaguaaagacuuggcugcagucaaagggauucaau

cccgugacugucaauagccucgggguguugaacggagcacaacucuuuucucucaacaaagacgaacugaggucugucugcc

cggaaggugccagagucuuuaaccaaaucacuguucagaaagcugcuuuggaggacaguaauggaagcuccgaguuacaaga

gaucaugcggagacggcaggagaagaucagcgccgcugcgagcgacucgggaguggagucuuuugaugaagggagcagcca

cugaguccaugaacuuccuuauucuugguguggucguugaacagugauggacaugcuuuguuuuaagaagccuugaaggg

aaugucaaagcugucgucuugguauauguaauuuaucgccauauaaggaaacaguauaugccugaguaagcagaggacccgc

ugcuucugugcacauuaguuugauuaaaacugagaagcggguaggugagauggcucagcaaguaaaggugcuugcugccaa

gcccaaugacccaaguucgagucccugggucuacaugguaggagagagcuggcuucugcaaguuguccucugaccaccacac

auaaauaaauaacaaauguaauuuacaaacuuuuaaaagaaaauguaauuuaaaaaaccagacguucuagacuguucugggc

uugggaaauauuuuuuucacuuuccuaagguguacuuuccuuugcuacauuaauuauugcagccuuguucgaugaucuaa

guggggauauuugacaauggcagauuuauucauugcaacaaggaaagacacagccauugaugaaaaaaaaaagaaagucuca

gcuuucagugacugggauaccugcuguccagggaggaggcucaguuagacuacccucugcuuacuugaggucugacaugcc

caaugagaguguauuuagcuuuauuuaaaguucuuaaugccaacaguuuuaaaaaucacauuuaaaugaacuguacaaggu

agccagaccuugaauguaugaauagacuauauaauaugucccgagaaacuuuguuacucucagcucuguugauugcgaaauc

uugcauagauuaugcuuugauuuaguuucu

Fyn/Fyn
10
Sequence below.
250

proto-

oncogene

M27266

ccugggccccgccgcggacgcgcggagccgccugggccgcgccggaggagggcggggagaggaccaugugaaugugcuccg

gagcugagcgccaagccaagcaguguuugaaaggaacaggaugcugaucuaaucguggcaaaaagucaguccgaccgcuggu

uucgaagacaugugguguauauaaaguuugugauaguugguggaaauuugggagcuuggauaaugggcugugugcaaugu

aaggauaaagaagcagcgaaacugacagaggagagggacggcagccugaaccagagcucuggguaccgcuauggcacagaccc

caccccucagcacuaccccagcuucggcgugaccuccaucccgaacuacaacaacuuccacgcagcugggggccagggacuca

ccgucuuugggggugugaacuccuccucucacacugggacccuacgcacgagaggagggacaggagugacacuguuugugg

cgcuuuaugacuaugaagcacggacggaagaugaccugaguuuucacaaaggagaaaaauuucaaauauugaacagcucgga

aggagauuggugggaagcccgcuccuugacaaccggggaaacugguuacauucccagcaauuacguggcuccaguugacucc

auccaggcagaagagugguacuuuggaaaacuuggccgcaaagaugcugagagacagcuccuguccuuuggaaacccaagag

guaccuuucuuauccgcgagagccaaaccaccaaaggugccuacucacuuuccauccgugauugggaugauaugaaagggga

ccacgucaaacauuauaaaauccgcaagcuugacaaugguggauacuauaucacaacgcgggcccaguuugaaacacuucagc

aacugguacagcauuacucagagaaagcugaugguuuguguuuuaacuuaacugugguuucaucaaguuguaccccacaaa

cuucuggauuggcuaaagaugcuugggaaguugcacgugacucguuguuucuggagaagaagcuggggcagggguguuuc

gcugaaguguggcuugguaccuggaauggaaauacaaaaguagccauaaagacccuuaagccaggcaccaugucuccggagu

ccuuccuggaggaggcgcagaucaugaagaagcugaagcaugacaagcuggugcagcucuacgcggucgugucugaggagcc

cauuuacaucgucacggaguacaugagcaaaggaaguuugcuugacuucuuaaaagauggugaaggaagagcucugaaguu

gccaaaccuuguggacauggcggcacagguugcugcaggaauggcuuacaucgagcgcaugaauuauauccacagagaucug

cgaucagcaaacauucuaguggggaauggacuaauuugcaagauugcugacuuuggauuggcucgguugauugaagacaau

gaauacacagcaagacaaggugcgaaguuucccauuaaguggacagcccccgaagcggcccuguauggaagguucacaauca

agucugacguauggucuuuuggaaucuuacucacagagcuggucaccaaaggaagagugccauacccaggcaugaacaaccg

ggaggugcuggagcagguggagagaggcuauaggaugcccugcccacaggacugcccgaucucccugcacgagcucaugauc

cacugcuggaaaaaggauccggaagagcgcccgaccuucgaguacuugcagggcuuccuggaggacuacuuuacggccacag

agccccaguaucagcccggugaaaaccugugagagccugcgcuucagacgccucuucccgaggccucccuaccccuccccauu

agcuuccaauucuguagccagcugccccagagcaggagaaccguccaggaucagauugcaugugacucuugaagcugaacuu

ccacggcccucauuaaugacacuugucccccaguccgaaccuccucugugaaccaucugagacagaagcguguuauuucuca

gacuuggaaaugcauuguaucgauguuaugucaaaggccaaaccucuguucaguguaaauagcugcuccugugccaacaauc

ccagugcuuuccuuuuuuaaaaaagaaaaagcaaauccuaugugauuuuaacucugauuucaccugauucaacuaaaaaaaa

aaaaguauuauuuuccaaaaguggccucuuugucuaaaacaauaaaauuuuuuuucauguuuuaacaaaaaaaaaaaaaaaa

aaaaaaaa

Structurally-related

Col6a1/
36
Sequence below.
251

Procol-

lagen, type

VI, alpha 1

X66405

cccucccuggcucucuccucagcucugggcucugacugcagcaagcagagacaaccucucacucugccuuucccagcgcccac

ccugacccuggcccacauuugacggugacucgcaggccagccagaaacaugaggcuggcccacgcucugcugccccugcugc

uacaagccugcuggguggccacacaggacauccagggcuccaaagcgauugccuuccaagacugcccuguggaucuauucuu

cgugcucgacaccucggagaguguggccuugaggcugaaaccuuauggggccuugguggacaaggugaaguccuucacuaa

gcgcuucauugacaaccugagagacagguacuaccggugugaccgcaaccugguuuggaaugcgggugcgcugcacuacag

ugacgagguggagaucauccgagggcucacgcgcaugcccaguggccgcgaugagcucaaggccagcguggaugcggucaag

uacuucgggaaaggcaccuacaccgacugcgccauuaagaaggggcuggaggagcugcucauagggggcucccaccugaagg

agaacaaguacuugaucguggugaccgacgggcauccucuagagggcuacaaggaaccaugcgggggucuggaagaugcagu

aaaugaggccaaacaccugggcaucaaggucuuuucuguggccaucacaccugaccaccuggagccacgucuaaguaucauu

gccacagaccacacauaccggcgcaauuucacggcagcugacugggggcauagccgcgaugcagaagaggucaucagccagac

cauugacaccauuguggacaugauuaaaaauaacguggaacaaguguguuguucuuuugagugccaggcugccagaggacc

uccagggccccgaggcgacccuggguaugagggggagcgaggaaagccaggucuuccgggagagaagggagaagcuggagac

ccuggacgaccuggggaucuuggaccagucggguaccaggguaugaagggagaaaaggggagccguggagagaaggguucc

agaggaccgaaagguuacaagggcgagaaaggcaagcgcggaaucgacggggucgacggcaugaagggagagacgggguacc

caggacuaccgggcugcaagggcuccccaggauuugauggcauucaaggacccccgggucccaagggugaugcuggugccuu

ugggaugaagggagaaaagggugaagcuggagcagacggugaggcugggagaccagggaacucagggucaccuggagauga

gggugauccuggagagccugguccccccggagaaaaaggagaggccggugaugaaggaaaugcuggcccagacggugccccu

ggagagagggguggcccuggugaaagaggaccucgggggaccccuggugugagaggaccaaggggagacccgggugaagcu

ggaccacagggugaccaaggaagagaggggcccgucggcaucccuggagacucgggugaggcuggccccauuggaccuaaag

gauaccgaggugaugaggguccuccagguccugagggccucagaggagccccaggaccuguugguccuccuggagaccccgg

acugaugggugagagaggugaggauggaccaccaggaaacggcacggaagguuuccccggcuucccuggguauccaggcaac

agaggcccuccugggcuaaauggcacaaaaggcuacccuggccucaagggggaugagggugaagugggagacccaggagagg

auaacaacgacauuucaccccguggggucaaaggggcaaagggauaccgaggcccagaaggaccccagggaccuccaggacau

gugggaccaccugggccagaugagugugagauccuggauaucaucaugaaaaugugcuccugcugugagugcacaugugga

cccauugacauccucuucgugcuggacagcucggagagcauuggccuacagaacuuugagauugccaaggacuucaucauca

aggucauugaccgguugagcaaggaugagcuggucaaauuugagccagggcagucucacgcgggcgugguacaguacagcc

acaaccagaugcaagagcacguggacaugcggagccccaacguccgcaacgcccaggacuucaaagaagcugucaagaagcua

caauggauggcugguggcacauucaccggagaagcgcugcaguacacccgggaccggcuacucccacccacacagaacaaccg

aauugcccuggucauuacggauggacguucugacacucaacgggacacgacaccucucagugugcucuguggugcagacauu

cagguaguuucugugggaaucaaggauguguuuggcuuuguggcgggcuccgaccagcucaaugucauuuccugccaaggc

uuaucgcaaggucguccagguaucucccuggugaaggagaacuaugcagagcuucucgaugacggcuuucugaagaacauaa

cagcccagaucuguauagauaagaaguguccggauuauaccuguccaaucacauucuccuccccggcugacaucaccauccu

gcuagacagcucagccagugucggcagccacaacuucgaaaccaccaaggucuucgccaagcgccuagcugagcgauuccug

ucagcaggcagggcggauccuucccaggaugugcggguggccgugguacaguauaguggccaggggcagcaacagccaggu

cgggcggcucuucaguucuuacagaauuacacagugcuggccagcucuguggacagcauggauuucaucaacgacgccacag

acgucaacgaugcucugagcuacgugacucguuucuaccgggaagccucgucaggugccaccaagaagagagugcuguugu

uuucagacggcaacucucagggggccacagcagaggccauugagaaggcugugcaggaggcccagcgugcaggcauugagau

cuuuguggugguggugggaccccaggugaacgagccccacauccgugugcuugucacuggcaagacugcagaguacgacgu

ggccuuuggcgagcgccaccuauuccguguaccaaacuaccaggcccugcuacguggcguacucuaccagacagucuccagg

aagguggcacugggcuagagggccacacacguggcuggacacacauggcauggagacacauuucaacaggccuucccgcccu

ucccacugacaaaacaggaauaggaaaugugacccaacuggucaacucaacugucuuaaagggaacgcugagaugcacacucu

uugcuuuguguaauguccccuguggcucaccugagcuccuaucuagaucccgcccuugguuuguacaucaugguggccauc

uugcugaccccucccccaucugggacuggauccagccaucucgucuuccuccucacugccccuaaccuauccguggugucuu

cacaccaucacugcaguuuccgucuguguucugucuuccaugcucaacaugaagcagaccuucucaugaguucagcuugcug

gauuauggcuuuuaggaaauugaacacaggaggaguuccaaacacaaacuuggaggagaccccuccucuucaucaggugcuu

gucagugaccuacaugcaucuuggucugguccuuaguggcuaguccuuccacucugaaagcaaaggugcuaucuaucugua

agggcucucucuacacacccagaggcuuagcuuggacaguucacacucaaguguccugucagaaucaauccagagcuuucuc

ccucaaaauagugacuugucucccccugguccccaaaggcuccccuuuaguuaguuucuucauggcucccccacauuccccg

uaaucugauccaagccagcuaucucugcuaauaaagguuuccauuuuucaaaaaaaaaaaaaa

Tnc/
17
accccaugccccacccccaccuucgauguuuugaacauuucuaacaacug
252

Tenascin C

aagccaguaaagucauauucuuuaaauuuccaggacauucauauuauuc

AV230686

acauaaucauggucauggugaugauggaaacugaggacuuuaaaagaga

X56304

uuuucccuucccaaacguuucuggacaguaccugauuguauuuuuuuug

uuuuguuuuguuuuuuaauaaaagcacaguacuuuucc

Krt2-6a/
10
Sequence below.
253

Keratin

complex 2,

basic, gene

6a (keratin

6a)

K02108

gucugcccugccguuucucuacuucccagccuucucaucuccaggaaccaugucuaccaaaaccaccaucaaaagucaaacca

gccaccguggcuacagugccagcucagccagagugcuuggacucaaccgcucgggcuucagcaguguguccgugugccgcuc

ccggggcagcgguggcuccagugcaauguguggaggagcuggcuuuggcagcaggagccucuaugguguggggagcuccaa

gaggaucuccaucggagggggcagcuguggcauuggaggaggcuauggcagccgauucggaggaagcuucggcauuggugg

uggagcugguaguggcuuuggcuucggugguggagcuggcuuuggugguggcuaugggggagcuggcuucccggugugc

ccacuuggaggcauccaagaggucaccaucaaccagagccuccucacaccccugaaccugcaaauugaccccaccauccagcg

ggucaggacugaggagagggagcagaucaagacccucaauaacaaguuugccuccuucaucgacaaggugcgguucauggag

cagcagaacaaggucauggacaccaagugggcccugcugcaagagcaggacaccaagaccgugaggcagaacauggagcccau

guuugagcaguacaucagcaaccuccgcagacagcuggacagcaucauuggagagaggggucgcaugaacucagagcugagg

aacaugcaggaacucguagaagaacuacggaacaaauaugaagaugaaaucaacaagcgcacagacgcagagaaugaauucgu

gacccugaagaaggauguagaugcugccuacaugaacaaaguugaacugcaagccaaggcagacagucuaacagaugauauc

aacuucuugagagcucucuaugaagcagaacugucucagaugcaaacucacaucucagacacaucugugguccucuccaugg

ucaacaaccguagccucguccuagacagcaucaucgcugaggucaaggcccaguuugaggucauagcucagagaagucgggc

ugaagcugagucauuguaccagacuaaauaugaggagcugcaggucacagcuggcagacauggggacgaccugcgcaacacc

aagcaggagauugcugagaucaaccgcaugauccagaggcugagaucugagaucgaccacguuaagaagcagugugccaacc

ugcaagcugcuauugcugaugcugagcaacguggggagauggcccugaaggaugcaaggggcaagcuggaagggcuggagg

augcccugcagaaggccaaacaggacauggccaugcugcugaaggaguaccaugaacucaugaaugucaagcuggcccuuga

uguggaaauugccaccuacaggaagcugcuggaaggagaggagugcagguugaauggugaagguguuggaccagucaacau

cucuguggugcaguccaccguguccagcggcuauggcagugccgggggugccagcagcagcuuaggcauggguggaggcag

cagcuacuccuauagcagcagccauggccuuggagguggcuucagugcuggcaguggcagagccaucggagguggccucag

cucuucugguggccucagcucuucuaccaucaaauacaccaccaccuccuccagcaagaagagcuacaggcagugaauucug

ucaccaagagcuugucucuggucccagaugucauggcugcagcugaaccacaugcuuugguucccggaagggaacgaauccc

aaccucuggccuccccauggcucaguucuacauuuguguugcacgucagcaccuauacauguucuuuggugacccagacccc

aaaauguugcagaauguagaccuccaagacgaaaccccaaacccuacccagaauacccaccuaaauucugucaugguucugac

uuccuccagagucuguaaaauaaaaugcccccacaacaaac

Channel-related

Potassium
14
uuuuuuuuuuuuuuuuugauuuuaauuacaaacuuuauuuguccuc
254

channel,

caguucacaguuuauacgugguacaucccaccaugucagcuuccagaa

subfamily

cggcuauucaggagauggguggagcuuucuuuguaaaggaacccgac

K, member 2

auuuuaaaauuuugguuagaaucuucauagguuuauaaaaguacucu

AI849601

cugcaagcgaacuggauauauuuacauuuauagcuuaaauucaaauu

uuggaaaauaggaaucuuuuuguguuuuuaaacauccuggguuuau

gucuuaagacuuuacucugaaugccacaugaucacguaagcccaagcc

ucccccagaagggaaaaaucaguuuugc

Skd3/
4
uuuuuuuuuuuuuuuuugggugccaugccacagcaaggggccuuua
255

Suppressor

uuagauguucagggcacagacagguggaugcuagaugguguagcaca

of K+

ccuucucaggguggaguggugccuggauguccaguuugcgggucuu

transport

gcuguccuuaucaaugaucuccagucgcaauguagguggacgcuucu

defect 3

cagccuggggugagggcagcucacggcucuugaggaggugcuugucc

AI837887

gaauccuccacagugauacccagggugcaacccccugg

Clic4/
3
uuuuuuuuuuuuuuucugacacaguaguaauccuuccagacuccuua
256

Chloride

cacaauauuacaacucccccaguacauaaauguuccuauaccaugcaca

intracellular

cagcaacaugggguccacugaugucgcaggcgacuuuucuaauggug

channel 4

gaacauagcaccucaaguucugccaucuacacagugaagggacgugau

(mito-

ggucggggcuccagagugacagcaaacugccucuugggugacacgcu

chondrial)

uguggcgaagugccucc

AI845237

Col18a1/
5
Sequence below.
257

Endostatin

(alpha

1(XVIII)

collagen)

L22545

gagaauguugcugaggagguggggcugcugcagcuccuuggagacccccuaccugagaagaucucacaaaucgaugacccuc

acgucgggccggccuacaucuuuggaccagacuccaacaguggccagguggcccaguaucauuucccaaaacucuucuuccg

ggacuuuucgcugcuguuucauguccggccagccacagaggcagcaggggugcuauuugccaucacagaugcugcccaggu

gguagucucacugggcgugaagcucucagagguccgagauggacagcaaaacaucucauugcucuacacggagccuggggcc

agccagacccagacgggagccagcuuccgccuaccugcauuuguugggcaguggacacacuucgcgcucagcgucgacggag

gcucuguggcucucuacguagacugugaagaauuccagagggugccauuugcucgggccucgcagggacuggagcuagagc

guggcgcuggccucuuugugggucaggcuggaacagcagacccugacaaguuccaggggaugaucucagagcugaagguac

gcaaaaccccccgggugagcccugugcacugucuggaugaagaagaugaugaugaagaccgggcaucuggagauuuuggaag

uggcuuugaagaaagcagcaagucacacaaggaggauacaucucuacuaccugggcucccucagccaccuccugucacuucc

ccaccccuggcuggaggcagcaccacagaagauccuagaacagaagaaacggaggaagacgccgcgguagauucuauaggagc

ugagacccuuccuggcacagguucaagcggugcaugggaugaggcuauccagaaccccggaaggggcuugauaaagggagg

uaugaaaggacaaaagggagaaccaggugcccagggcccaccuggcccagcuggcccccaggguccugccgguccagugguc

cagagccccaacucacaaccugucccuggagcacaaggacccccgggaccucaggggccaccagggaaggauggcacuccagg

aagggauggugaaccgggugacccuggugaagaugggagaccgggugacacuggaccucaaggcuuuccagggaccccagga

gaugugggcccuaagggcgagaagggagauccugguauugggccccgaggaccuccagggccuccagggccaccaggacccu

ccuucagacaagacaagcugaccuucauugacauggagggauccgguuucagcggagacauagagagccuuagaggcccacg

aggcuucccuggccccccggggcccccuggugucccaggacuuccuggugagccaggacgcuuugggaucaaugguuccua

ugcaccaggaccugcaggccuuccugguguaccugggaaggaaggaccccccgguuuuccaggucccccgggaccuccaggu

ccuccaggcaaagagggcccaccaggaguggccggccagaaaggcaguguuggugaugugggcaucccaggacccaagggga

gcaaaggagaccuugggcccaucgguaugccuggcaagucuggcuuggcuggauccccugggccaguuggacccccaggacc

uccagggccuccagggccaccaggaccaggauuugcugcuggauucgaugauauggaaggcucuggaauaccccucuggaca

acagcccgaagcucugaugggcugcagggaccucccgggucgccgggacucaagggggauccuggaguggcaggccuaccug

gagccaagggagaaguuggagcagauggagcccagggcaucccuggucccccaggaagagaaggugcagcuggaucuccggg

gccaaaaggagagaaggggaugccgggagaaaagggaaacccaggaaaagauggagugggccggccgggccucccugggccu

ccaggaccuccagggcuggugaucuaugugucaagugaggauaaagcaauagugagcacgccaggaccugagggcaagccag

gguacgcaggcuuuccuggaccugcuggaccgaagggugaccuggguuccaaaggcgagcagggucuuccgggguuuaagg

gugagaagggagagccaggcacuaucuuuaguccugauggcagacgucugggccauccccagaagggagccaagggagagcc

aggcuuucgaggacccccggguccuuauggacgaccugggcacaagggugaaauuggcuucccuggacggccgggucgacc

uggaacgaauggcuuaaagggagagaagggagagccuggagaugccagccuuggguucagcaugaggggauugccuggccc

cccugggccuccaggacccccagguccuccugggaugcccaucuaugacagcaaugcauuuguggagucuggccgaccugga

cuaccaggacagcagggugugcaggggccuucaggaccaaagggugacaaaggagagguggggccaccugggccaccagggc

aauuccccauugaccucuuccaccuggaagcggaaaugaagggggacaagggagaccgaggggaugcuggacagaaaggaga

gaggggagaaccuggggcuccuggugguggauucuucagcucaaguguaccuggcccacccggcccaccuggauacccugga

auuccggguccaaagggagagagcauccgggggccaccuggcccuccuggcccgcagggaccuccuggcauuggcuaugagg

gucgccagggucccccaggaccuccaggaccuccaggaccucccuccuucccuggcccucacagacagacugucaguguuccu

gguccuccgggcccaccugguccuccaggucccccaggagccaugggugccucugcugggcaggugaggaucugggccacau

accagaccaugcuggacaagauccgggaggugccggagggcuggcucaucuuuguggccgagagggaagagcucuauguac

gcguuagaaauggcuuccggaaggugcugcuggaggcccggacagcccuccugagaggcacgggcaaugagguggcugcuu

uccagcccccauugguccagcuucaugagggcaguccauacacccggagggaguacuccuauuccacggcacgacccuggcg

agcagaugacauccuggccaacccaccgcgccugccagaccgccagccuuacccuggaguuccacaucaccacaguuccuaug

ugcaccugccgccagcccgccccacccucucacuugcucauacucaucaggacuuucagccagugcuccaccugguggcacu

gaacaccccccugucuggaggcaugcgugguauccguggagcagauuuccagugcuuccagcaagcccgagccguggggcug

ucgggcaccuuccgggcuuuccuguccucuaggcugcaggaucucuauagcaucgugcgccgugcugaccgggggucugug

cccaucgucaaccugaaggacgaggugcuaucucccagcugggacucccuguuuucuggcucccagggucaagugcaacccg

gggcccgcaucuuuucuuuugacggcagagauguccugagacacccagccuggccgcagaagagcguauggcacggcucgga

ccccagugggcggaggcugauggagaguuacugugagacauggcgaacugaaacuacuggggcuacaggucaggccuccucc

cugcugucaggcaggcuccuggaacagaaagcugcgagcugccacaacagcuacaucguccugugcauugagaauagcuuca

ugaccucuuucuccaaauaggccucugccagcuaggguggcagacagaggccaugcagaacuuugacacagcgcagggagca

uucagucagcacccagggcucuggcugggauacaacuccuguauaguucccauuuuuauguaauccucaagaaauaaaagga

agccaaagaguaaaaaaaaa

TABLE 5

Genes down-regulated in HF stem cells.

Gene
Fold

Name/protein
Decr
Sequence
SEQ ID No.

Growth Factors, Receptors and Downstream genes

GNA-14
32
Sequence below.
258

Mouse G

protein alpha

subunit (GNA-14)

M80631

aacugccuucgagaagcguuagccuagagauccgagccucuucuccauaccauaguugguucaggugguuuccucuucaaac

cuugcgucugcggauaauccgcgcggccgggcguuaagcuccaggucccugucgcuccgucgagguggcaagccauggccg

gcugcugcuguuugucugcggaggagaaagagucucagcgcaucagcgcggagaucgagcggcacguucgccgcgacaagaa

ggacgcgcgccgggagcucaagcugcuguugcugggaaccggugagagugggaaaagcaccuuuaucaagcagaugaggau

aauccaugggucuggcuacagugaugaagauagaaagggcuucacgaagcugguuuaccaaaacauauucacggccaugcaa

gccaugaucagagcaauggauacccugaggauacaauacaugugugagcagaauaaggaaaaugcccagaucaucagggaag

uggaaguagacaaggucacugcacucucuagagaccagguggcagccaucaagcagcuguggcuggaucccggaauccagga

guguuacgacaggaggagggaguaccagcugucagacucugccaaauauuaccugacggacauugagcguaucgccaugccc

ucuuucgugccaacacaacaggaugugcuucguguuagagugcccaccacuggcaucauagaauauccauucgaccuggaaa

acaucaucuuccgaaugguggauguugguggccagcgaucugaacgacggaaauggauucacugcuuugagagugucaccu

ccaucauuuucuugguugcucugagugaauaugaccagguucuggcugagugugacaaugagaaccgcauggaggagagca

aagcccuguuuagaaccaucaucaccuaccccugguuucugaacuccuccgugauucuguucuuaaacaagaaggaucuucu

agaggagaaaaucauguacucucaucuaauuagcuacuucccagaguacacaggaccaaagcaagaugucaaagcggccaggg

acuuuauccugaagcuguaucaagaccagaauccugacaaagagaagguuaucuauucucacuucacuugugcuacagacac

cgagaauauccgcuuuguguuugcugcugucaaagacacaauccuacagcuaaaccuacgggaguucaacuugguguaaaug

gagggccuacuccuccgagacagagggugaucugagcccuuccugccugaucuacaagugcuucuggaccaggaccuaagga

cauuauguagcccacaggacagagauggguagugcaaugugaaaaauacuucaccaacccuuuuaagugucuuuaauucuuc

acugucuaacucuuuucucgccuuuugguugaacgauuagguaucauuuuugagugguucccccucuccuauuuuuuuaa

acuaguguucaacaguuauuaaaaaaucaugc

Ly6/Lymphocyte
12
gaauucccugcaaccuugucugagaggaagcaaggacuggugugagg
259

antigen 6

agggagcugugagguuuuaucugugcagcccuucucugaggaugga

complex

cacuucucacacuacaaaguccuguuugcugauucuucuuguggccc

X04653

uacugugugcagaaagagcucagggacuggaguguuaccagugcua

uggagucccauuugagacuucuugcccaucaauuaccugccccuacc

cugauggagucuguguuacucaggaggcagcaguuauuguggguuc

ucaaacaaggaaaguaaagaacaaucuuugcuuacccaucugcccucc

uaauauugaaaguauggagauccuggguacuaaggucaaugugaaga

cuuccuguugccaggaagaccucugcaaugcagcaguucccaaugga

ggcagcaccuggaccauggcaggggugcuucuguucagccugagcuc

aguccuccugcagaccuugcucugaugguccucccaaugaccuccac

ccuuguccuuuuauccucaugugcaacaauucuuccuggagcccucu

agugaugaauuaugaguuauagaagcuccaaggugggaguagugug

ugaaauaccauguuuugccuuuauagcccugcuggguagguaggug

cucuaauccucucuagggcuuucaagucuguacuuccuagaauguca

uuuuguuguggauugcugcucaugacccuggaggcacacagccagca

cagugaagaggcagaauuccaagguauuaugcuaucaccauccacac

auaaguaucugggguccugcaauguucccacauguauccugaauguc

ccccuguugaguccaauaaacccuuuguucuccc

Bmp4/Bone
11
Sequence below.
260

morphogenetic

protein 4

L47480

ggaagaaagagagggagggaaaagagaaggaaggaguagaugugagaggguggugcugagggugggaaggcaagagcgcga

ggccuggcccggaagcuaggugaguucggcauccgagcugagagaccccagccuaagacgccugcgcugcaacccagccuga

guaucuggucuccgucccugaugggauucucgucuaaaccgucuuggagccugcagcgauccagucucuggcccucgacca

gguucauugcagcuuucuagagguccccagaagcagcugcuggcgagcccgcuucugcaggaaccaauggugagcagggcaa

ccuggagaggggcgcuauucugaggauucgaggugcacccguaguagaagcuggggauggggcucaggcuguaaccgaggc

aaaaguuggccuauuccuccuuccuucuccaacaguguuggaggugggaugauggaggcuaaaaggcaccuccauauaugu

uacugcgucuaucaaccuacuuuagggaggugcgggccaggagaggcgggaaggagagaaggccuuggaagagaggucauu

gggaagaacugugggguuugguggguuugcuuccacuuagacuauaagagugggagaggagggagucaacucuaaguuuc

aacaccagugggggacugaggacugcuucauuaggagagagaaccuagccagagcuagcuuugcaaaagaggcuguaguccu

gcuuugcucuaaagcgcgacccgggauagagaggcuuccuugagcggggugucaccuaaucuuguccccaacgcacccccuc

ccagccccugagagcuagcgaacuguagguacacaacucgcucccaucuccaggagcuauuuucuuagacaugggcacccau

gauucugccuucugguacucuccccucccugggaaagggguguaagguuccgacggaaccguggccaggaugccgaaaggc

uaccugugcgggucuucugccaugcugugucugugcggacaugccagcagggcuaaugaggagcuugcgauacuccaaagg

guucgggaauugcgggguccuuacacgcaguggaguugggccccuuuuacucagaagguuuccgccacggcuuugguugau

aguuuuuuuaguauccugguuuaugaacugaagguuuugugagauguugaaucacuagcagggucauauuuggcaaaccg

aggcuacuauuaaauuuugguuuuagaagaagauucuggggagaaagugaaggguaacugccuccaggagcuguaucaacc

ccauuaagaaaaaaaaaaauaccaggagaugaaaauuuacuuugaucuguauuuuuuaauuaaaaaaaaucagggaagaaag

gagugauuagaaagggauccugagcgucggcgguuccacggugcccucgcuccgcgugcgccagucgcuagcauaucgcca

ucucuuucccccuuaaaagcaaauaaacaaaucaacaauaagcccuuugcccuuuccagcgcuuucccaguuauucccagcgg

cgacgcgugucggggaauagagaaaucgucucagaaagcugcgcugaugguggugagagcggacugucgcucaggggcgcc

cgcggucucugcacccagggcagcagugugggauggcgcugggcagccaccgccgccaggaaggacgugacucuccauccuu

uacacuucuuucucaaagguuucccgaaagugccccccgccucgaaaacuggggccggugcggggggggggagagguuagg

uugaaaaccagcuggacacgucgaguuccuaagugaggcaaagaggcgggguggagcgggcucuggagcgggggaguccug

ggacucgguccucggauggaccccgugcaaagaccuguuggaacaagaguugcgcuuccgagguuagaacaggccaggcauc

uuaggauagucaggucacccccccccccaaccccacccgaguuguguuggugaauuucuuggaggaaucuuagccgcgauuc

uguagcuggugcaaaaggaggaaaggggugggggaaggaaguggcngngcggggguggcgguggggguggaggugguuua

aaaaguaagccaagccagagggagaggucgagugcaggccgaaagcuguucucggguuuguagacgcuugggaucgcgcuu

ggggucuccuuucgugccggguaggaguuguaaagccuuugcaacucugagaucguaaaaaaaaugugaugcgcucuuucu

uuggcgacgccuguuuuggaaucuguccggaguuagaagcucagacguccaccccccaccccccgcccacccccucugccuu

gaauggcaccgccgaccgguuucugaaggaucugcuuggcuggagcggacgcugagguuggcagacacgguguggggacuc

uggcggggcuacuagacaguacuucagaagccgcuccuucuaacuuucccacaccgcucaaaccccgacacccccgcggcgga

cugaguuggcgacggggucagagucuucuggcugaaaguuagauccgcuaggggucggcugccugucgcuagaagcauuau

uuggccucucggagacccguguggaggaagugcuggagugugcgaguguguuugcgugugugugugugugugugugugu

gugugugugugugugugugugcgcgcgcccuuggagggucccuaugcgcuuuccuuuucauggaacgcugucgugaggcu

uugguaaacugucuuuucgguuccucucucggcugcacuuaagcuuugucggcgcuguaaagagacgcgucuucaagugca

cccugauccucaggcuucagauaacccguccccgaaccuggccagaugcauugcacugcgcgccgcagguagagacgugccc

cacguccccugcgugcagcgacuacgaccgagagccgcgccaguguggugucccgccgagaguuccucagagcaggcgggga

caacucccagacggcuggggcuccagcugcgggcgcggagguuggccucgcucgcaggggcuggacccagccgggguggga

ggauggaggaggggcgggcgggcucuucggugaguggggcggggccucuggguccacgugacuccuaggggcuggaagaa

aaacagagccugucugcuccagagucucauuauaucaaauaucauuuuaggagccauuccguagugccauucggagcgacgc

acugccgcagcuucucugagccuuuccagcaaguuuguucaagauuggcucccaagaaucauggacuguuauuaugccuug

uuuucugucagugaguagacaccucuucuuucccuucuugggauuucacucuguccucccaucccugaccacugucugucc

cucccgucggacuuccauuucagugccccgcgcccuacucucaggcagcgcuaugguucucuuucuggucccugcaaggcca

gacacucgaaauguacgggcuccuuuuaaagcgcucccacuguuuucucugauccgcugcguugcaagaaagagggagcgcg

agggaccaaauagaugaaagguccucagguuggggcugucccuugaagggcuaaccacucccuuaccagucccgauauaucc

acuagccugggaaggccaguuccuugccucauaaaaaaaaaaaaaaaaacaaaaaacaaacagucguuugggaacaagacucu

uuagugagcauuuucaacgcagcgaccacaaugaaauaaaucacaaagucacuggggcagccccuugacuccuuuucccagu

cacuggaccuugcugcccgguccaagcccugccggcacagcucuguucuccccuccuccuguucuuaaccagcuggaaguug

uggaaauugggcuggagggcggaggaagggcggggguggggggguggagaaggugggggggggggaggcugaagguccga

agugaagagcgauggcauuuuaauucucccuccnccuccccccuuuaccuccucaauguuaacuguuuauccuugaagaagc

cacgcugagaucauggcucagauagccguugggacaggauggaggcuaucunauuugggguuauuugaguguaaacaaguu

agaccaaguaauuacagggcgauucuuacuuucgggccgugcauggcugcagcugguguguguguguguagggugugagg

gagaaaacacaaacuugaucuuucggaccuguuuuacaucuugaccgucgguugcuaccccuauaugcauaugcagagacau

cucuauuucucgcuauugaucgguguuuauuuauucuuuaaccuuccaccccaacccccuccccagagacaccaugauuccu

gguaaccgaaugcugauggucguuuuauuaugccaaguccugcuaggaggcgcgagccaugcuaguuugauaccugagacc

gggaagaaaaaagucgccgagauucagggccacgcgggaggacgccgcucagggcagagccaugagcuccugcgggacuucg

aggcgacacuucuacagauguuugggcugcgccgccguccgcagccuagcaagagcgccgucauuccggauuacaugaggga

ucuuuaccggcuccagucuggggaggaggaggaggaagagcagagccagggaaccgggcuugaguacccggagcgucccgcc

agccgagccaacacugugaggaguuuccaucacgaaggucaguuucugcucuuaguccuggcgguguagggugggguagag

crccggggcagaggguggggggugggcagcuggcagggcaagcugaagggguuguggaagcccccggggaagaagaguuca

uguuacaucaaagcuccgaguccuggagacuguggaacagggccucuuaccuucaacuuuccagagcugccucugaggguac

uuucuggagaccaaguagugguggugaugggggaggggguuacuuugggagaagcggacugacaccacucagacuncugcu

accncccagnggguguucuuuagcuauaccaaagncagggauucugcccguuuuguuccaaagcaccuacugaauuuaaua

uuacancuguguguuugucagguuuaucaauaggggccuuguaauacgaucugaauguuuccuagcggauguuucuuuuc

caaaguaaaucugaguuauuaauccuccagcaucauuacuguguuggaauuuauuuucccuucuguaacaugaucaacaag

gcgugcucuguguuucuaggaucgcuggggaaauguuugguaacauacucaaaaguggagagggagagaggguggccccuc

uuuuucuuuacaaccacuuguaaagaaaacuguacacaaagccaagagggggcuuuaaaaggggaguccaagggugguggag

uaaaagaguugacacauggaaauuauuaggcauauaaaggagguugggagauacuuucugucuuugguguuugacaaaugu

gagcuaaguuuugcugguuugcuagcugcuccacaacucugcuccuucaaauuaaaaggcacaguaauuuccuccccuuagg

uuucuacuauauaagcagaauucaaccaauucugcuauuuuuuguuuuuguuucuuguuuuuguuuuguuugguuuuuu

uuuuuuuuuuuuuuuuuuugucucagaaaagcucaugggccuuuucuuuuccccuuucaacugugccuagaacaucugga

gaacaucccagggaccagugagagcucugcuuuucguuuccucuucaaccucagcagcaucccagaaaaugaggugaucucc

ucggcagagcuccggcucuuucgggagcagguggaccagggcccugacugggaacagggcuuccaccguauaaacauuuau

gagguuaugaagcccccagcagaaaugguuccuggacaccucaucacacgacuacuggacaccagacuaguccaucacaaugu

gacacggugggaaacuuucgaugugagcccugcaguccuucgcuggacccgggaaaagcaacccaauuaugggcuggccauu

gaggugacucaccuccaccagacacggacccaccagggccagcaugucagaaucagccgaucguuaccucaagggaguggaga

uugggcccaacuccgcccccuccuggucacuuuuggccaugauggccggggccauaccuugacccgcaggagggccaaacgu

agucccaagcaucacccacagcgguccaggaagaagaauaagaacugccgucgccauucacuauacguggacuucagugacgu

gggcuggaaugauuggauuguggccccacccggcuaccaggccuucuacugccauggggacugucccuuuccacuggcuga

ucaccucaacucaaccaaccaugccauugugcagacccuagucaacucuguuaauucuaguaucccuaaggccuguuguguc

cccacugaacugagugccauuuccauguuguaccuggaugaguaugacaaggugguguugaaaaauuaucaggagauggug

guagagggguguggaugccgcugagaucagacaguccggagggcggacacacacacacacacacacacacacacacacacaca

cacacacacguucccauucaaccaccuacacauaccacacaaacugcuucccuauagcuggacuuuuaucuuaaaaaaaaaaaa

aagaaagaaagaaagaaagaaagaaaaaaaaugaaagacagaaaagaaaaaaaaaacccuaaacaacucaccuugaccuuauuu

augacuuuacgugcaaauguuuugaccauauugaucauauuuugacaaauauauuuauaacuacauauuaaaagaaaauaaa

augag

IL1r2/Interleukin 1
11
gaaucccacuuacaugcgagcaucucuauauacauccucaaucuauc
261

receptor, type

cccucgaauccacggacuuaucagucaaucaauacuacagucaaagaa

II

uuuuuuucuacguuauccuggagcauugcgcuggcaccucuuuuuc

AV223216

uaaucaucuugguuguggggccaauauggaugcgcagacgguguaa

X59769

acgcagggcuggaaagacauauggacugaccaagcuacggacugaca

accaggacuucccuuccagcccaaacuaaauaaaggaaaugaa

Wnt3a/wingless-
4
Sequence below.
262

related MMTV

integration site

3A

X56842

gaauucaugucuuacggucaaggcagagggcccagcgccacugcagccgcgccaccucccagggccgggccagcccaggcgu

ccgcgcucucgggguggacuccccccgcugcgcgcucaagccggcgauggcuccucucggauaccucuuagugcucugcagc

cugaagcaggcucugggcagcuacccgaucuggugguccuuggcugugggaccccaguacuccucucugagcacucagccca

uucucugugccagcaucccaggccugguaccgaagcagcugcgcuucugcaggaacuacguggagaucaugcccagcguggc

ugagggugucaaagcgggcauccaggagugccagcaccaguuccgaggccggcguuggaacugcaccaccgucagcaacagc

cuggccaucuuuggcccuguucuggacaaagccacccgggagucagccuuuguccaugccaucgccuccgcuggaguagcuu

ucgcagugacacgcuccugugcagagggaucagcugcuaucugugggugcagcagccgccuccagggcuccccaggcgaggg

cuggaaguggggcggcuguagugaggacauugaauuuggaggaauggucucucgggaguuugccgaugccagggagaaccg

gccggaugcccgcucugccaugaaccgucacaacaaugaggcugggcgccaggccaucgccagucacaugcaccucaagugca

aaugccacgggcuaucuggcagcugugaagugaagaccugcugguggucgcagccggacuuccgcaccaucggggauuucc

ucaaggacaaguaugacagugccucggagauggugguagagaaacaccgagagucucguggcuggguggagacccugaggc

cacguuacacguacuucaaggugccgacagaacgcgaccuggucuacuacgaggccucacccaacuucugcgaaccuaacccc

gaaaccggcuccuucgggacgcgugaccgcaccugcaaugugagcucgcauggcauagaugggugcgaccuguugugcugc

gggcgcgggcauaacgcgcgcacugagcgacggagggagaaaugccacuguguuuuccauuggugcugcuacgucagcugc

caggagugcacacgugucuaugacgugcacaccugcaaguaggagagcuccuaacacgggagcaggguucauuccgaggggc

aagguuccuaccugggggcgggguuccuacuuggaggggucucuuacuuggggacucgguucuuacuugagggcggagau

ccuaccugugagggucucauaccuaaggacccgguuucugccuucagccugggcuccuauuugggaucuggguuccuuuuu

aggggagaagcuccugucugggauacggguuucugcccgaggguggggcuccacuuggggauggaauuccaauuugggccg

gaaguccuaccucaauggcuuggacuccucucuugacccgacagggcucaaauggagacagguaagcuacucccucaacuag

gugggguucgugcggaugggugggaggggagagauuagggucccuccucccagaggcacugcucuaucuagauacaugaga

gggugcuucagggugggcccuauuugggcuugaggaucccgugggggcggggcuucaccccgacuggguggaacuuuugg

agacccccuuccacuggggcaaggcuucacugaagacucaugggauggagcuccacggaaggaggaguuccugagcgagccu

gggcucugagcaggccauccagcucccaucuggccccuuuccaguccugguguaagguucaaccugcaagccucaucugcgc

agagcaggaucuccuggcagaaugaggcauggagaagaacucaggggugauaccaagaccuaacaaaccccgugccugggua

ccucuuuuaaagcucugcaccccuucuucaagggcuuuccuagucuccuuggcagagcuuuccugaggaagauuugcaguc

ccccagaguucaagugaacacccauagaacagaacagacucuauccugaguagagaggguucucuaggaaucucuaugggga

cugcuaggaaggauccugggcaugacagccucguaugauagccugcauccgcucugacacuuaauacucagaucucccggga

aacccagcucauccgguccgugauguccaugccccaaaugccucagagauguugccucacuuugaguuguaugaacuucgga

gacauggggacacagucaagccgcagagccaggguuguuucaggacccaucugauuccccagagccugcuguugaggcaaug

gucaccagauccguuggccaccacccugucccgagcuucucuagugucugucuggcccuggaagugaggugcuacauacagcc

caucugccacaagagcuuccugauugguaccacugugaaccgucccucccccuccagacaggggaggggauguggccauaca

ggagugugcccggagagcgcggaaagaggaagagaggcugcacacgcguggugacugacugucuucugccuggaacuuugc

guucgcgcuuguaacuuuauuuucaaugcugcuauauccacccaccacuggauuuagacaaaagugauuuucuuuuuuuuu

uuuucuuuucuuucuaugaaagaaauuauuuuaguuuauaguauguuuguuucaaauaauggggaaaguaaaaagagagaa

aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

Il12rb2/
3
Sequence below.
263

Interleukin 12

receptor, beta 2

U64199

cgcaccggagguccacacugccgcguggacuccagcgauggcgcugcgcuaggcuagcgggugccaggaucccucucugcgu

ccugugcgcgggaagagcucuggagaaccagaguugcauucuggaguugaagacucauggcacagacuguuagagaaugcu

cauuggcacuucuuuuuuuguucauguggcugcugauuaaagcaaauauagaugugugcaagcuuggcacugugaccgucc

agccugccccugugauuccucuugggucagcugccaauauuuccugcuccuugaaucccaagcaaggcuguucacauuaucc

caguucuaacgaauuaauccucuuaaaguuugucaaugauguccuuguugaaaaucuccauggcaagaaaguccaugaccac

acuggucacuccuccacuuuucaagucaccaaccugucccuugguaugaccuuguuugucugcaagcuaaacuguagcaacu

cucaaaagaagccaccagucccaguaugugggguggagaucucaguugguguugcuccagagccaccucaaaacauaucaug

uguccaggaaggagaaaauggaacuguggccuguuccuggaacucuggaaaaguuacuuaucugaaaaccaauuacacuuua

caguuaaguggaccaaacaaucugaccugucagaaacaauguuuuucugacaaucgucagaauugcaaucgccuggaucuug

ggaucaaucuaagcccugauuuagcugaauccagguucauaguccguguuacugccaucaacgaucuuggaaauucuucuu

cacuuccgcauacguucacguucuuggacauagugaucccucuuccuccgugggacaucagaaucaacuuucuaaaugcuuc

ugggagcagagguacacugcagugggaagaugaggggcaagugguacucaaucaacucagauaucagccucuuaacagcacg

uccuggaacauggucaaugcuacaaaugccaaaggaaaauaugaccugcgagaucugagaccguuuacagaauaugaauuuc

aaaucuccucuaagcuacaucucucuggaggaaguuggaguaauuggagugagucacugagaacacgaacaccagaggaaga

gccuguugggauauuagacaucugguacaugaaacaagacaucgacuaugacagacagcagaucucucuuuucuggaagagu

cugaauccaucagaggcaagggggaagauccuccacuaucaggugacguuacaagaggugacaaagaaaacaacacugcagaa

uacuacaagacacaccuccuggaccagggucaucccccgaacuggggcuuggacggcaucagugucugcagccaacucaaaag

gcgcuucugcacccacucacauuaacauaguggaccuauguggcacuggguugcuggcuccucaccaggucucugcaaaguc

ggagaacauggacaacauucuagugaccuggcagccuccuaagaaagcugauucugcuguucgggaguacauaguggaaug

gagagcucuccaaccagggagcaucacgaaguuucccccacacuggcugcggauccccccggacaacaugucugcucugauu

ucagagaacauaaagcccuauaucuguuaugaaaucagggugcaugcacugucagagagccaaggagggugcagcuccaucc

ggggugacuccaagcacaaagcaccagugaguggcccucacauuacugccaucacagagaaaaaggaacgccuuuucauuucc

uggacccacauuccauucccggagcaaaggggcugcauccuccauuacagaauauacuggaaagaacgagacucgacagcaca

accugagcucugcgaaauucaguaccgacgcucucaaaacucacauccaauaagcagccuacagcccagggugacauaugucc

uauggaugacagcugugacagcugcuggugaaaguccccaaggaaaugaaagggaauuuuguccacagggcaaagccaacug

gaaagcauucgugauaucaagcauuugcaucgcuaucaucacggugggcacguucucaauucguuacuuccggcaaaaggca

uuuacucuccugucuacucucaaaccucaaugguauagcagaaccauuccagauccagcaaacagcacuuggguaaagaagu

aucccauucuggaggagaagauccagcuaccuacggauaaucuccugauggcauggcccacuccugaagagccugagccccu

gaucauccaugaaguccucuaccacaugaucccaguugucagacaaccauauuacuucaaaagaggccaaggauuccaaggcu

acucuaccuccaagcaagaugcaauguauauugccaauccacaagcuacaggaacucucacagcugagaccagacaacuagug

aaccuauacaaggugcuagaaagcagagacccugacucaaaacuggccaaccugaccagccccuugacagucaccccagugaa

cuaccuuccuagccaugaaggcuauuuacccuccaacauagaagaucugucaccacaugaggcugacccaacugauucuuuu

gaccuggagcaucaacauauuucucuuuccauuuuugcaucaaguucucuccgcccacucaucuucgguggugagcggcug

acucuagaucgguuaaagaugggcuaugacucccucaugaguaaugaggcuugauacuagaaagccaacguaccucauuuua

ucugcccaguuccuacuccaaaggucugugacagugaagacaagccagcugucucuggauaaaguuagcuucaccauaggua

cuuaagucuuauggauaagguggcaauacaccaacacugauaucauauagaaaggaccccaagauagucaugcuc

Wnt10a/Wing-
3
Sequence below.
264

less-related

MMTV

integration site

10a

U61969

ggcacgaguucacccucugcaugcguuccccuccccccucuccagcaaacacggcgcgccaguccaaagcggacucaguggcc

ucggggacgggagcaugccaccuccuguggugacgucacuugggguagaacccuuagacacuacaugggggggggggguac

agaacucccgagccaggacagucacucacucuucaggcgguggggcugggccagacaguaccgcccccaccgcgcccgccucg

cacacccucggaagcgcaggcucgcagcgcggcgcuggggugggggguugcgccccagaacuucggccuccaguccccagcc

cgcugcaccuccuuacccucuagaggcccccucccccuuacccucuagaggcaccaggaguugucgcaaggggcccuuggga

aauucccuggaccccugugccaggaggugcccgguucgcccgcuccccauccacccccccgagggcggugcccgggggcgcu

gccccauggagcggggaggcgggcgccgucugcugcgggagcugugaccugaguaggagcugugugucgcagccgccccac

cccugccgaucaugcgccggcgacccugguucgccagucccacugggcugugagccccccacuccuggccugucacggcccg

cgcgccaugggcagcgcccacccucgccccuggcugcggcucccacaagggccccagccgcggccugaguucugggcgcucc

uguucuuccuacugcugcuggcugccgcugugcccaggucagcacccaacgacauccugggccuccgccuacccccagagcc

cgugcucaacgccaacacagugugccugacauugcccggccugagccggcggcagauggaggugugugugcgucacccugac

guggccgccucugcuauccagggcauccagaucgccauccaugagugccagcaucaguuccgggaccagcgcuggaacugcu

ccagccuggagacucggaacaaaguccccuacgagagccccaucuucagccgagguuuucgagagagugcuuucgccuacgc

cauagcagcugccgggguggugcacgcaguguccaacgcgugcgcucuggguaaacugaaggcuugcgguugcgacgccuc

cagacguggggacgaagaagcuuuccgucggaagcugcaccgcuugcagcuggacgcgcugcagcgcggaaagggcuugagc

cacggggucccugaacacccggccauacuuccugccagcccaggucugcaggacuccugggagugggguggcugcaguccgg

augugggcuucggagaacgcuucucuaaggacuuucuggacucccgagagccucacagagacauccaugcucgaaugagacu

ccacaacaaccgugugggccggcaggcggugauggagaacaugcggcguaagugcaaaugccacggcaccucaggcagcugc

cagcucaagaccugcuggcaggugacgccugaguuccgcacaguaggggcgcugcugcgcaaccgcuuccaccgcgccacgc

ucauccggccgcacaaccgcaacgguggccagcuggagcccggccccgcgggagcacccucgccagcaccgggcacuccaggg

cugcgccgcagggccagccacuccgaccuggucuacuuugagaaaucucccgacuucugugagcgcgagccgcgccuggacu

cggcaggcacugugggccgccugugcaauaagagcagcacgggucccgauggcugcggcagcaugugcuguggccgcggcc

acaacauucugcgccagacgcgcagcgagcgcugccacugccgguuccacuggugcugcuucguggucugcgaagaaugccg

caucaccgagugggucagcgucugcaagugagcagacccaagcuccucugggucucaagaaugguuguccucuuggugccu

ggcuucugccgcuagcggaucugagccaggcagcaagcagcagccuuggcuccugagagaggugguuggcucuuacagcccc

gagggucuacaaucaccagacaguccagaucugauugacauuccuccgcucaccucuguagguuccccucuuucuguuccua

gcucagacagcugggggugauaguggagacuguuccacacccuaggacaggucaccaaagcagcccagccuggcaugccuac

cuccugucaucucuucuucccuuccccaggagugauaggcaaugcacugaagcugaugggcaccggggaagaaaacuaaaag

gcagaaauggccgucaucgggcugaagugacucuaagggcuccagaccucugcuccugucuuucacuuaacagauauuuau

uuuugcgcucucuuugagacacucucuggggaaaaagaagcuccggagucuacaggcugauuaagggacauggacaauaaac

caguaaacacacaaaaaaaaaaaaaaaaaa

Ifngr2/Interferon-
3
Sequence below.
265

gamma

receptor

precursor

M28233

gaauuccgggccgcuugcacuuggcgacuagucugcggcggacgugacgccaaggccacgggcagcgcggguccccugucag

aggugucccucgcgcaggaaugggcccgcaggcggcagcuggcaggaugauucugcuggugguccugaugcugucugcgaa

ggucgggaguggagcuuugacgagcaccgaggauccugagccucccucggugccuguaccgacgaauguucuaauuaaguc

uuauaacuugaacccugucguaugcugggaauaccagaacaugucacagacuccuauuuuuacuguacagguaaaggugua

uucggguuccuggacugauuccugcaccaacauuucugaucauuguuguaauaucuaugaacaaauuauguauccugaugu

aucugccugggccagaguuaaagcuaagguuggacaaaaagaaucugacuaugcacggucaaaagaguuccuuaugugccua

aagggaaaggucgggcccccuggccuggagaucaggaggaagaaggaagaacagcucuccguccucguauuucacccugaag

ucguugugaauggagagagccagggaaccauguuuggugacgggagcaccuguuacacauucgacuauacuguguaugugg

agcauaaccggaguggggagauccuacauacgaaacauacggucgaaaaagaagaguguaaugagacucugugugaguuaaa

caucucaguauccacacuggauuccagauauuguauuucaguagacggaaucucaucuuucuggcaaguuagaacagaaaaa

ucgaaagacgucuguaucccuccuuuccaugaugacagaaaggauucaauuuggauucuggugguugcuccucuuaccguc

uuuacaguaguuauccugguauuugcguauugguauacuaagaagaauucauucaagagaaaaagcauaauguuaccuaag

uccuugcucucugugguaaaaagugccacguuagagacaaaaccugaaucgaaguauucacuugucacaccgcaccagccag

cuguccuagagagugagacggugaucugugaagagccccuguccacagugacagcuccagacagccccgaagcagcagaaca

ggaagaacuuucaaaagaaacaaaggcucuggaggcuggaggaagcacgucugccaugaccccagacagcccuccaacuccga

cacaaagacgcagcuuuucccuguuaaguaguaaccagucaggcccuuguagccucaccgccuaucacucccgaaacggcuc

ugacaguggccucgugggaucgggcagcuccauaucggacuuggaaucucucccaaacaacaacucagaaacaaagauggca

gagcacgacccuccacccgugagaaaggcccccauggccuccgguuaugacaaaccgcacauguugguggacgugcuugugg

auguuggggggaaggagucucucaugggguauagacucacaggagaggcccaggagcuguccuaaggucucccgaggccug

cuggugguaaagaaacugaccuuuuaggcaguuuuucugcauugauuucaugaaagaagcuauacauuagcuaauacuaac

cacauagaauaucagacuuagauacgugaauaaggauccugugggcacugcuggguccacucugcaaaugccaagacuauca

aaggaacguauugucgcuucuggcuccuucccaggugggcuagcaucugugaguuugccucggcuagccuugcuuccuaca

gccgccacugcuccuccacccugaucaucucacaggacaggguggaccggguuuuuuuuuuuuuuucacacaccuuuguau

auguaaguucauguauauaauauguuuacauguuucacuuugaacugaaagcuacucaaagccagccguaagucuauggua

gaaugugauggaacauguugguggaagcuuguacaauagaacacauuggugggagcuuguacauacuuuuuuauggagcau

uacuuacgauuuuuuaaguaaaauguuuugaaaccaaaaaaaaaaaaaggaauuc

Fgfbp1/
3
augagacuccacagccucauccugcucuccuuccuucuccuggcuac
266

Fibroblast

ucaggcguucucagaaaaggucagaaagagagccaagaacgcaccaca

growth factor

cagcacagcggaggaggggguagaggguucagcucccucguuaggga

binding protein 1

aggcccagaauaagcagagaagcaggacaucuaaaucucugacgcaug

AF065441

gcaaguuugucaccaaagaccaagccacaugcagaugggcugugacu

gaggaggagcagggcaucagccugaagguccagugcacacaagccga

ucaggaguuuucuuguguuuuugcuggugacccaacugacugccuu

aaacacgacaaagaccagaucuacuggaaacagguugcccgcacgcug

cgcaaacagaaaaauaucugcaggaacgccaagagugucuugaagacc

agagugugcagaaagagauuuccagagucuaaccucaagcuggugaa

ccccaacgcacguggaaacacgaagcccaggaaggagaaagcagaggu

cuccgcaagggagcacaacaagguccaagaagcugucuccacggagcc

aaacagggucaaagaagacaucacacucaauccagcugcgacccagac

cauggccauuagagauccagagugucuagaggauccagaugugcuca

accagaggaagaccgcccuggaguucuguggggaaucuuggagcucc

auuugcacauucuuccucaacauguuacaggcgacaucaugcuaa

Transcription Factors and Related Genes

Klf5/Kruppel-
5
aauucgucgacaugcgccguuccagugcauggugugccaacgcagcu
267

like factor 5

ucucccgcuccgaccaccucgcgcugcacaugaagcgccaccagaacu

AA611766

gagcgagcgagcgcugccccacccgccugacgccuugcaguccgcuc

ugccauccuuuaaaccgcagaccuaacuucauaaaaaga

Gata3/GATA
4
Sequence below.
268

binding protein 3

X55123

gcuaaacuaucccgcaaagauuuuucuuuccucccuaaacccuccuuuuugcucuccuuuucuauacccuuaacugcaaaca

aaccauuaaacgaccccucuccugggccuccgacggcaggaguccgcggaccucccaggccgacagcccucccucuacccgcg

agguuccgggccgggcgagagggcgcgagcacagccgaggacauggaggugacugcggaccagccgcgcugggugagccacc

aucaccccgcgguccucaacggucagcacccagacacgcaccacccgggccucggccauucguacauggaagcucaguauccg

cugacggaagagguggacguacuuuuuaacaucgauggucaaggcaaccacgucccguccuacuacggaaacuccgucaggg

cuacggugcagagguauccuccgacccaccacgggagccagguaugccgcccgccucugcugcacggaucucugcccuggcu

ggauggcggcaaagcccugagcagccaccacaccgccucgcccuggaaccucagccccuucuccaagacguccauccaccacg

gcucuccggggccucuguccguuuacccuccggcuucauccucuucucuggcggccggccacuccaguccucaucucuucac

cuucccgcccaccccgccgaaagacgucuccccagacccgucgcuguccaccccgggauccgccgggucggccaggcaagaug

agaaagagugccucaaguaucaggugcagcugccagauagcaugaagcuggagacgucucacucucgaggcagcaugaccac

ccuggguggggccucauccucagcccaccaccccauuaccaccuauccgcccuaugugcccgaguacagcucuggacucuuc

ccacccagcagccugcugggaggauccccuaccggguucggauguaagucgaggcccaaggcacgauccagcacagaaggca

gggagugugugaacugcggggcaaccucuaccccacuguggcggcgagaugguaccgggcacuaccuuugcaaugccugcg

gacucuaccauaaaaugaaugggcagaaccggccccuuaucaagcccaagcgaaggcugucggcagcaaggagagcagggaca

uccugcgcgaacugucagaccaccaccaccacccucuggaggaggaacgcuaauggggacccggucugcaaugccugugggc

uguacuacaagcuucauaauauuaacagaccccugacuaugaagaaagaaggcauccagacccgaaaccggaagaugucuagc

aaaucgaaaaagugcaaaaaggugcaugacgcgcuggaggacuuccccaagagcagcuccuucaacccggccgcucucuccag

acacaugucaucccugagccacaucucucccuucagccacuccagccacaugcugaccacaccgacgcccaugcauccgcccu

ccggccucuccuucggaccucaccacccuuccagcauggucaccgccauggguuagagaggcagagcccugcuccacaugcg

ugaggagucuccaagugugcgaagaguuccuccgaccccuucuacuugcguuuuucgcaggagcaguaucaugaagcccgaa

agcgacagaucuguguuuuugaaggcagaaagcaaaauguuugcuucuuuuuucaaaggagcucgagguggugucugcauu

ccaaccacugaauccggaucccauuugugaauaagccauucagacucauauucccuauuuaacagggucucuagugcuguga

aaaaaauauugcugaacauugcauauaacuuauauuguaagaaauacuguacauuugaggaagacuuuauuguaccuggau

agcuguaagaaaggcaugaaggacgccaagaguuuuaaggaauauaggggnnuuaaaguauggagauacagaagaaaccacu

aagucugauguccaaaugggcacacugucaguuuuguuucccuucaguuguuugaugcauuuaaaaaaaaaaaaaagaaagaa

Stimulated by
3
Sequence below.
269

retinoic acid

14, basic-helix-

loop-helix

protein

Y07836

caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucagggauggauuuugcccacauguacc

aaguguacaaguccaggcggggaauaaaacggagcgaagacagcaaggaaacuuacaaacugccgcaccggcugauugagaaa

aagagacgugaccggauuaacgagugcauugcccagcugaaggaucuccuacccgaacaucucaaacuuacuacuuuggguc

acuuggaaaaagcagugguucuggagcuuacguugaagcacgugaaagcauugacaaaucuaauugaucagcagcagcagaa

aaucauugcccugcagagcgguuuacaagcuggugauuugucgggaagaaaucucgaggcagggcaagaaauguucugcuc

agguuuccagacuugugcccgugagguacuucaguaccuggcgaagcaugagaacacucgggaccugaaaucuucccagcuc

gucacucaucuccaucguguggucucggagcugcugcaggguggugcuuccaggaaaccauuggacucggcucccaaagcc

gucgacuugaaagagaagcccagcuuccuagccaagggaucagaaggcccagggaaaaacugugugccagucauccagcgga

cuuuugcucccucggguggggagcagagcggcagugacacggacacagacaguggcuauggaggugaauuggagaaagggg

acuugcgcagugaacagccguacuucaaaagcgaccauggacgcagguucgccgugggagaacgugucagcacaauuaagca

agaauccgaagagccccccaccacaaagagccgaaugcagcucucagaagaggaaggccacuucgcgggcagugaucugaugg

guuccccauuucuugggccacacccacaucagccuccuuuuugccuucccuucuaucucaucccaccaucggccacugccua

ccugccuaugcuggagaaaugcugguaccccaccucugugccaguguuauacccaggccucaacaccucagcugcagcccuc

uccagcuucaugaacccagacaagauaccgacucccuugcuucugccccagagacucccuucuccuuuggcacauucguccc

uugacucuucggccuugcuccaggcuuugaagcagaucccuccuuuaaacuuagaaaccaaagacuaaacucuggagggauc

uccugcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccugagugcagagagaucagcccacccugc

agacccacagagaagauucagagugugugugagagugagugagugugcgugcgugcgugcuuguauguauguuuguauau

guaggacaauaaguuccuucugacacaagggagacacgagaaggauagccugacaucagaugacagacuggaggacuguagc

acaucucugggcguuucccuacccagagaagagcc

Cell Cycle Related

Mki67/antigen
4
Sequence below.
270

identified by

monoclonal

antibody Ki67

X82786

agucaccgacguuguauaacgacggccagugaauuguaauacgacucacuauagggcgaauuggguaccggccccccccucg

aggucgacgguaucgauaagcuugauaucgaauucucgnccgcgugcgggucuggucggggcggagcgaaggccgcgggug

gccguggucgguccuccgcggcuaaggagccgagggcuccgacgcgggcugcgcccggugagcggcggccagagcuaacuu

gcgcugacuggaccagcugaggagcggcccggcggggcgacugcgagcuucaccgagaggcuucuccgcccugguccgcagu

cccgacggccgggcggaccauggcguccucggcucaccuggucaccaucaagcggagcggcgaugacggcgcacacuucccg

cugagccucagcuccugccuguuuggaaggaguauugaaugugacauucguauccagcugccuguagugucucaaagacau

ugcccaauuguaguccaagagcaagaggcgauauuauauaauuucaguucuaccaauccaacucaaguaaacgggguuacua

uagaugagccugugaggcugagacauggagacauaauaaccaucauugaccgcuccuuuagguaugaagauggaaaucauga

ggauggaagcaaaccaacagaauuuccaggaaagucccuuggaaaggaaccaucaaggcgagccucaagagauagcuucugu

gcugacccugauggggaaggucaagauaccaaagcuucaaaaaugacugcuucaagaagaucuuuuguguaugccaagggcc

uuucugcagauagcccugccucagauggcucaaagaacaguguuagccaagacucaucagggcauguagaacagcacacugg

cagaaacauaguagagcccacuucugggggaucucuuuuaagaaguccaggucuacagggagcaguuacagggaaccgaagu

cuucuuccauacacagagccuuagcaauagcaacgaaaaggaaucucccuuugagaaacuuuaucaaucaaugaaggaagagu

uggauguaaaaucccagaaaucuuguaggaaaucagaaccccaaccugaccgugcagcagaggaaucgcgggagacacagcua

uuggugucaggcagggcaagagcaaagucuaguggaagcaccccuguuacugcagccucuucacccaaaguaggaaagaucu

ggacugagagauggcgcgguggaauggugccuguccagacuuccacagagacagcuaaaaugaagaccccugugcggcauuc

acagcaacuuaaggaugaagacucucguguuacuggcagacgacauucugugaaucuggaugaagguggaagugcccaggca

guccauaaaacagucacuccugggaaacuggcgacuagaaaccaaacuccgguggaggcuggggauguuggcagccccgcug

auacaccagaacauuccucuuccccccagagaaguauuccugcaaagguagaggcuccaucugcagagacacaaaaucggcuc

ucuuuaacucagcgccuuguuccaggugaaaagaaaacucccaaggguuccuucagcaagccugagaaacuggccacagccg

ccgaacagacuugcucuggccuaccuggucuuaguuccguugauaucagcaacuuuggugauuccauuaacaagagugagg

gaaugccuaugaagagaagacguguauccuuugguggacaucuaagaccugaauuauuugaugaaaacuugccuccuaauac

accacugaaaagaggagaaacgccaaccaagaggaagucucuuggcacucacagcccagcuguccucaagacaaucaucaagg

aacggccccagucuccagggaaacaagagucuccugggauaacgccaccgaggacaaaugaucaaagacgcagaucaggcagg

acuuccaguggaagcaauuucuuaugugagacagacauucccaagaaagcaggcaggaagagcgguaaccugccugcgaaga

gagcauccaucagccggagucagcauggcauucuacagaugauuugcuccaaaaggcgaaguggagcuucugaagccaacuu

gauuguugcaaaaucaugggcugauguuguaaaacuuggcgugaaacaaacacaaacgaaaguugcgaaacaugucccucca

aagcagacgagcaagagacaaagaagacccagcacuccaaagaaacccacaagcaaucuucacaaucaauuuacuacaggccau

gcaaacucucccuguaccauuguaguagguagagcgcagauugaaaaaguaagugugccugcccgacccuacaaaaugcuga

auaacuugaugcuaaaccgaaaaguggacuucagugaagaucugucaggacuaacugaaauguucaagacuccagugaagga

gaagcagcagcagaugagugauacaggcuccguacuuuccaauucagcgaauuugucugaaagacaauugcaaguaacuaau

ucaggagacauaccugagcccaucaccacagagauuuugggagaaaaagugcuauccaguacucggaaugcagcaaagcagca

gucugauagauauucugcaaguccuaccuuaagacggcggagcaucaaacaugaaaacacagugcaaacuccuaagaauguc

cauaacauuacugaccuugagaagaagacuccggucucugagacagagccccugaagacugcaucgagugugagcaaguuaa

gaagaucuagagagcucagacauacccuuguggaaacuaugaaugaaaaaacagaagcaguccuugcugagaacaccacagca

agacauuuaagggggacauuucgagaacaaaaaguagaucaacaggugcaggacaaugaaaacgcuccucaaagaugcaagga

aaguggugaauuaagugaagguucagaaaagacaucagcuaggagaucaagugccaggaagcagaagccgacaaaagacuua

cuaggaagucagauggucacccaaacagcagacuaugcugaggaacuacuuagucaaggacaaggaaccauacaaaaccuaga

ggaauccaugcacaugcaaaacacaucaauaagugaggaucaaggaauuacagaaaagaaagugaacauaauaguauaugcaa

ccaaagagaagcacucgccaaagaccccuggcaaaaaggcacaaccucuagaagggccagcuggucucaaggaacacuuugaa

acaccaaaccccaaagauaaaccuauaacggaagacagaacuagaguccuuugcaaaucaccacaagucacaacagagaauauc

acaacaaacacaaagccacagacuagcacaucugggaagaaaguagacaugaaggaagaaagcucugccuugacaaaacguau

acauaugccaggggaauccaggcauaaucccaaaauuuuaaaacuugagugugaggauaucaaagcuuugaagcaaucugaa

aaugaaaugcugaccucaacaguaaauggaagcaagaggacuuuaggaaaaucuaaaaaaaaggcucagccccuggaagaccu

gacuuguuuccaggaacucuuuauaucaccaguuccuacuaacauaaucaaaaaaauucccagcaaaucuccacacacacaac

cagucagaaccccagcgagcacaaagagacucuccaagacaggucucaguaaaguggaugugagacaagaaccuucaacacuu

gggaaaagaacgaagucaccaggcagagccccaggcacaccagcaccagugcaggaagaaaaugacugcacagccuacaugga

aacuccaaagcagaaacuggagucuauagaaaauuuaacagggcuuaggaaacaguccagaacaccuaaagacaucacugguu

uccaggauaguuuccaaauaccagaucaugcuaauggcccauuagugguugucaaaaccaaaaaaauguucuuuaauucucc

acaaccagaaagugccauaacccgaaagagcagagagagacagucuagggcaaguauaaguaaaauagauguuaaagaagaac

uuuuagaaucagaggaacaccuacaauuaggagaagguguagacacauuucagguauccaccaacaaagucauuagaucauc

uaggaaaccugcaaagcguaaacuggauucaacagcugguaugccuaacagcaagaggaugcgcuguucuucaaaggauaac

acaccaugccuagaagaccugaauggcuuccaagagcucuuccaaaugccaggcuaugcuaaugacucuuugaccacuggaa

ucucaacaaugcuugcuagaucaccacaauuaggaccaguuagaacccaaaucaacaaaaagagucugcccaagaucaucuug

agaaaaauggaugugacagaagaaauuucaggucucuggaagcagucacugggcagaguccacaccacacaagagcaggagg

auaaugcaaucaaagcaauuauggagauuccaaaggaaacacugcagacugcagcagauggaacuaggcuuaccagacagcca

caaacaccuaaggaaaaaguucaaccgcuggaagaucacagugucuuccaagaacucuuccaaacaucacgcuacuguucuga

uccauuaauugguaacaaacaaacaagaauguccuugagaucuccacaaccaggauuuguuagaacuccacgaaccucaaaga

gacuggcuaagacaaguguugggaauauugcugugagagaaaagaucucuccagugagucugccacagugugcuacagggg

agguuguacacauacccauagggccagaagaugacacagagaacaaaggugugaaggaauccacaccucagacacuggacuca

ucagcaagucgaacugucagcaagaggcagcaaggggcacaugaggaaaggccucaguucucaggagacuuauuucaucccc

aagagcucuuucaaacaccagccaguggcaaagacccaguaacuguugaugaaacuacaaaaauagcucugcagucuccacaa

ccaggacauaucauaaacccagcaagcaugaagagacaguccaacaugagucucaggaaagacaugagagaauuuuccauacu

ugaaaaacaaacacagucacgaggcagagacgcaggcacaccagcaccaaugcaggaagaaaauggcaccacagccauuaugga

aacaccaaagcagaaacuggauuucauaggaaauucaacaggacauaagaggaggccucggacacccaaaaacagggcucagc

cccuagaagaccuggauggcuuccaagaacucuuucaaacaccagcuggugccagugacccugugaguguugaagaaagugc

aaagauaucuuuggcaucuucacaagcagaaccagucagaaccccagcaaguacaaagagacgcuccaagacaggucucagua

aaguggaugugagacaagaaccuucaacacuugggaaaagaaugaagucacuaggcagagccccaggcacaccagcaccagug

caggaagaaaaugacagcacagccuucauggaaacuccaaagcagaaacuggauuucacaggaaauucaucaggacauaagag

gaggccacagacaccuaagaucagggcucagccccuagaagaccuggauggcuuccaagaacucuuccaaacaccagcuggug

ccaaugacucagugacuguugaggaaaguguaaagaugucuuuggaaucuucacaagcagaaccagucaaaaccccggcaag

cacaaagagacucuccaagacaggucucaguaagguggaugugagagaagacccuucaauacuugagaaaaaaacaaagucac

caggcacaccagcaccagugcaggaagaaaaugacugcacagccuucauggaaacuccaaagcagaaacuggauuucacagga

aauucaucaggacauaagaggaggccacggacaccuaagaucagagcucagccccuagaagaccuggauggcuuccaagaacu

cuuccaaacaccagcuggugcuagugacucagugacuguugaggaaagugcaaagaugucuuuggaaucuucacaagcaaaa

ccagucaaaaccccggcaagcacaaagagacucuccaagacaggucucaguaagguggaugugagagaagacccuucaacacu

ugggaaaaaaacaaagucaccaggcagagccccaggcacaccagcaccagugcaggaagaaaaugacagcacagccuucaugg

aaacuccaaagcagaaacuggauuuugcagagaauucaucagggaguaagagaaggucacgaacaucuaagaacaggucuca

gccccuagaagaccuggauggcuuccaagaacucuuccaaacaccagcuggugccaguaacccugugaguguugaagaaagu

gcaaagauaucuuuggaaucuucacaagcagaaccagucagaacccgggcaagcacaaagagacuuuccaagacaggucucaa

uaagauggaugugagagaagggcacucuccgcucaguaagucaagcugugcaucacagaaagucaugcaaacccucacacuu

ggagaagaucauggcagagagaccaaagaugggaagguauuguuagcucagaaauuggaaccagcaauauauguuacucgug

gcaagaggcagcaaaggucauguaagaaaaggucccaguccccagaagaccucucugguguucaggaggucuuccaaacauc

aggccauaacaaggauucagugacaguggacaaucuugcaaaacugcccagcucgucuccaccacuagagccaacagacacuu

caguaaccucacggagacaggccagaacuggucugaggaaaguucacgugaaaaaugaacuuucaggaggcauaaugcaucc

acaaauaucaggggaaauuguggacuuaccuagagaaccagaaggugaaggcaaagucauuaaaacaaggaagcaaucugua

aaacggaaauuggacacagaagucaaugugccucgcaguaagaggcaaagaauuacaagagcagaaaagacccuagaggaucu

gccuggcuuccaagagcucugccaagcuccaagcuugguaauggacucaguuauuguugagaaaaccccaaagaugcccgac

aaaucuccagaaccuguggauacaacuucagagacacaggcaagaagaagacucaggagacugguuguuacugaagagccca

uaccacaaagaaagacuacaagaguuguaaggcaaaccagaaacacacagaaagagcccauaagugacaaucaagguauggaa

gaguuuaaggaaucuucaguacagaaacaagacccaaguguaaguuuaacuggcaggaggaaccaaccaaggacaguuaagg

agaaaacccaacccuuagaagaacucaccaguuuccaagaggaaacugccaaaagaauaucuuccaaaucuccacaaccggaag

agaaggaaaccuuagcagguuuaaagaggcagcucagaauacaacuaaucaacgaugguguaaaagaagagcccacagcacag

agaaagcaaccauccagggaaaccaggaacacacucaaagagccuguaggugacaguauaaauguugaagagguuaagaaguc

uacaaagcagaaaauugauccaguagcaagugugccugucagcaagaggccacggaggguacccaaggaaaaggcacaggccc

uagaauuggcuggucucaaaggaccaauccaaacccuaggccacacugaugaaucagcaagugauaaaggacccacacagaug

cccuguaauucucuacaaccagagcaaguugacagcuuccaaagcucaccaaggcgacccaggacaagacgugggaaaguaga

ggcagaugaagagccuucagcaguaagaaagacaguaucaacaucaaggcaaacuaugcgaucccgcaaggucccugaaauug

guaacaaugguacccaaguuucaaaggccuccauaaagcagacauuagauacaguagccaaaguaacuggcagcaggaggcag

cuaaggacacauaaaggaugggguucaacccucuugaaguuguuaggugacuccaaagaaauaacccaaauaucagaucacu

cugagaaacuagcacaugacaccaguauccuuaagagcacucaacagcaaaagccagacucaguaaaaccucugagaacaugc

agaagagugcugagggccucuaaagagguccccaaggaaguguugguggacaccagagaccaugcaacauuacaaagcaaaa

gcaacccuuugcuguccccgaagaggaagucugcaagagauggaagcauugugagaaccagggcuuugcgcucuuuagcacc

aaagcaggaagcaacagaugagaagccuguaccugagaaaaaaagggcugcuuccagcaagagguauguaucaccugagccu

gugaagaugaaacaccugaaaaucgugucaaacaaacuugaaucuguggaagagcagguuagcacuguuaugaaaacagaag

aaauggaagccaaaagagaaaauccugucacuccagaucagaacucuagguaccgaaagaaaaccaauguaaaacagccaagg

cccaaguuugaugcaucugcagagaaugucgggauaaagaaaaacgagaagacuaugaagacugccucccaggagacagagc

ugcagaauccagaugauggagccaagaaaucuacaucucggggccaagucagugggaaaagaacaugcuugaggucuagagg

aacgacugagaugccccagccuugugaagcagaagagaaaacaagcaaaccagcugcagaaaucuugauaaagccucaggaag

agaaaggagucucuggagagucugauguuagguguuugagguccagaaaaacuagagucgcuuuggacagugaaccuaagc

caaggguaacucguggaaccaagaaagaugcaaaaacucugaaggaggaugaagacauuguaugcaccaagaaguuaagaaca

agaaguuaagaacaagaaguuaccagaaaagugaaacuauguagcaaagacauuuaagaaggaaaaguaaauuugacuuagu

gauaaguuccagugugguuuucaccuccaguguaaagaugaacuguaaauacuacugcuacugccugaguuuaaggaagga

agcuuugagcuuuccuggucauacucucuucagacgccaauggaggucaugaggaagaucaccagggaucucagcgcaauua

caguuuaggggugagcaggcagaaauguggcccucuguccuauccaauaaagcucugaaauucgcugccaaaa

Cks2/CDC28
4
gacguagagccccuugcgcccgguuuccugaucccgcuuacuc
271

protein kinase

cucugcgcgccggcaggauggcccacaagcagaucuacuacuca

regulatory

gacaaguacuucgaugagcacuacgaguaccggcaugucaugu

subunit 2, sim

uacccagagaacucucuaaacaaguacccaaaacucaucugaug

to cdk

uccgaagaggaguggaggagacuugguguccaacagagucuag

regulatory

gauggguucauuacaugauucaugagccagaaccgcauauucu

subunit 2

ucucuuuagacgaccucuuccaaaagaacaacaaaaaugaagug

AA681998

cagcugggaucaucuaaucuuuuucaaauuuaauguauaugu

guauauaagguaguauucagugaauacuugaaaaguguacaaa

ccuuucauccauaccugugcaugcgcuguauucuucacagcaa

cagagcucagucaaaugcaacugcaaguagg

Ccng2/
3
Sequence below.
272

Cyclin G2

U95826

cuacccuagacaaucacggcuuagccggcgcgcggagucgaucgucucggucgcuagagcuguccugagcucgaacgguccg

acgcccccgccgcgccgguccgugacgccggggccgacacgaugaaggauuugggggccaagcacuuggcagguggcgaagg

gguucagcuuuucggauuguugaacuucuaccuggaacaagaacagagauaccaaccucgggaaaaagggcugaucuugaug

gaggcuaccccggagaaugauaacacuuuguguucaagacugagaaaugccaaaguggaagauuuaagaaguuuaacuaacu

ucuuuggaucuggcacugaaacuuucguucuggcugucaauauuuuggauagauucuuggcccuuaugaaggugaaaccga

aacaccuguccugcauuggcgucugcugcuuuuugcuggccgccaggcuggcggaagaagaaggugacguuccccccacgca

cgacgugauccgcaucagucaguguaaaugcacagcgucugacauuaaacgcauggagaaaaucaucucagagaaacugcac

uaugagcuggaagcuaccacugccuuaaacuuuuugcacuuguaccacgcgauuguauuuugucacacuucagaaaggaag

gagauucucagccucgauaaacucgaagcgcagcugaaagcuugcaacugccgaguugucuucuccaaagcaagaccaucug

uauuagcucugugccuucucaauuuggaaauagaaacgauaaaauccguggaacugcuggaaauucucuugcuuguuaaaa

aacauuugaagcucagcgacacugaauucuuuuacuggagggaacugguuucuaaaugucuagcagaguauucuucgccuc

gcugcugcaagccugaucugaagaagcugguauggauuguuucgcgacgcacugcgcagaaccuccacagcagcuacuacag

uguuccugagcugcccacuaucccagagggggguugcuuugacggaagugaaagugaggacucuggugaagacaugaguug

uggagaggagagucucagcagcuccccacccagcgaucaggagugcaccuucuucuuugacuuccaaguggcucagacacug

ugcuuuccaccauagaggaaucugacauuguucugugucagggaauuuauaaguguguguaccuagguuucaaagcaauaa

acuuggggguugaauaggguaguuuuccuagguuuccagccccccgucuagucagg

Prc1/Protein
3
aacuaccuugggcagguucuauuaacugcaccuaacucagacg
273

regulator of

ugaguaggacagaaggaagcugucccgggcgaacugaggucac

cytokinesis 1

aaagacuugcuuuugauucaagagagaccuuaaaggcuaguua

DNA segment,

ugauaguuaaguacaaguuuuaacaucugguagcuaacuuuu

Chr 7

uuucucuaccccguaauucuacuaugacugcucuucuagaggu

AA856349

ccugaguucaaaucccagcaaccacaugguggcucacaaccauc

uauaaugggaucugaugcccucuucuggugugc

Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate, contribute significantly to induction of epidermal cells to differentiate into HF stein cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for preventing EDIHN and eliminating hair follicles. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 5 is a method for enhancing EDIHN. In addition, activation of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN.

Example 10

Expression of Wnt-1 Inhibitors During the First Nine Days after Wounding Causes Pigmentation of New HF

Materials and Experimental Methods

In this Example, doubly transgenic mice expressing both tetO-Dkk1 and K5-rtTA were utilized. When these mice are fed chow formulated with 1 g/kg doxycycline (BioServ, Laurel, Md.), they express Dkk1, under the control of the K5 promoter, in the basal epidermis. The control mice also received doxycycline, but they were K5-rtTA negative and thus did not express Dkk1.

Results

A 1 cm²wound was induced on the lower back of the doubly transgenic mice at 21 days or 50 days old. Mice were placed on doxycycline-containing chow immediately after wounding to induce Dkk1 expression, and then doxycycline was discontinued after completion of the re-epithelialization at 9 days after wounding. Dkk1 expression inhibits Wnt activity, which in turn induces follicle pigmentation. At 22 days after wounding, pigmented HF were observed in the excised skin after preparing the epidermal sheet (FIG. 23A-B). Control mice lacked pigmented HF (FIG. 24).

In other experiments, continued expression of Dkk1 after the 9-day period inhibited formation of new HF.

The findings of this Example show that pigmented HF can be produced by suppressing expression of Wnt1 or by inducing expression of Dkk1 during the period of re-epithelialization, then inducing expression of Wnt1. In addition, the findings of this Example show that factors that inhibit neonatal hair follicle formation (e.g. Dkk1) also inhibit EDIHN, thus further supporting the notion that hair follicles formed by EDIHN are similar to normal hair follicles.

Example 11
Inhibition of EDIHN by Epidermal Growth Factor Injection

21 day-old mice were wounded as described in previous Examples. Starting from day 11 after wounding, a time point corresponding to the point at which the wound had recently reepithelialized, 10 μL of 1 μg/ml EGF was injected into the wound bed. EGF was injected once per day after this point for a total of 5 days. Three days later, the skin was collected, and whole-mount EDIHN assays were performed. EGF prevented HF formation as assessed by gross morphology. In addition, whole mounts of control and treated skin were analyzed with anti-K17 antibody immunostaining. All mice injected with EGF (n=4) exhibited no new HF formation (FIGS. 25 A-B), while control mice (n=2) had many new HF, as expected. (FIGS. 25 C-D).

In an additional experiment, recombinant EGF (1 microgram (mcg)/microliter (mcl)) was injected at days 11, 13 and 15 after wounding. Skin was collected at 18 days after wounding and stained for K17 and alkaline phosphotase. Once again, administration of EGF inhibited EDIHN.

The findings of this Example show that EGF inhibits HF formation. Thus, inhibiting EGF, EGFR, or one of the pathways in which they participate increases EDIHN-induced HF formation.

Example 12
Enhancement of EDIHN by Inhibition of EGF Receptor

To determine the effect of administration of EGF receptor inhibitors on DIHN, the inhibitor AG1478 (150 μM in 10 μL volume) was administered as a single injection 11 days after incisional wounding (1 cm²) to the middle of the wound near the skin surface. EGF receptor inhibitor administration led to generation of more and larger hair follicles compared with control mice that were wounded only (FIG. 26A). As shown in FIG. 26B, large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing dermal papilla areas.

The findings of this Example confirm the results of the previous Example, and show that more and larger HF can be generated when EDIHN comprises, or is followed by, administration of EGFR inhibitors, or with compounds with a similar mechanism of action; e.g. Hedgehog protein and androgen antagonists.

Example 13
Enhancement of EDIHN by Expression of a β-Catenin Activator

To determine the effect of administration of β-catenin activators on EDIHN, K14-Wnt7 transgenic mice, which overexpress the β-catenin pathway activator, Wnt7, in the epidermis, were subjected to EDIHN, then HF formation was measured 19 days after wounding. In each of 2 separate experiments, with 4 week old and 3 week old mice, the transgenic mice developed significantly larger numbers of HF compared to control, non-transgenic littermate mice (FIG. 27 A-C).

Thus, administration of β-catenin activators leads to an increase in EDIHN. The findings of Examples 11-13 show that new HF can be generated by (a) disrupting the epidermis; and (b) administering a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell.

Example 14
Enhancement of EDIHN by Administration of FGF

To determine the effect of fibroblast growth factor (FGF) on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. FGF administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering FGF, a nucleotide encoding FGF, or a factor that increases signaling by FGF.

Example 15
Enhancement of EDIHN by Administration of EDAR

To determine the effect of fibroblast growth factor (FGF) on EDIHN, K14-Eda-A1 transgenic mice, which overexpress (ectodysplasin-A1) Eda-A1 in the epidermis, are subjected to EDIHN, then HF formation is measured 19 days after wounding as described in Example 13. The transgenic mice develope significantly larger numbers of HF compared to control, non-transgenic littermate mice, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering a factor that enhances signaling by ectodysplasin.

Example 16
Enhancement of EDIHN by Administration of Minoxidil

To determine the effect of minoxidil on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. Minoxidil administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering aminoxidil.

Example 17
Removal of HF by Abrasion and Administration of EGF

Hair-bearing regions of the epidermis of mice is abraded, as described in Example 1, then administering recombinant EGF, as described in Example 1. This method prevents hair re-growth in the abraded areas, showing that hair can be removed by (a) disrupting the epidermal layer; and (b) administering EGF, a nucleotide encoding EGF, or a factor that increases signaling by EGF.

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Number	Date	Country
2003-081866	Mar 2003	JP
WO 9901034	Jan 1999	WO
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WO 2005017107	Feb 2005	WO
WO 2010056759	May 2010	WO

	Number	Date	Country
	60665857	Mar 2005	US
	60683293	May 2005	US

	Number	Date	Country
Parent	11887104		US
Child	13327611		US

Methods for generating new hair follicles, treating baldness, and hair removal

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Entry
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